# Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri-n

Authors: Vasilios I. Balas; Sotiris K. Hadjikakou; Nick Hadjiliadis; Nikolaos Kourkoumelis; Mark E. Light; Mike Hursthouse; Apostolos K. Metsios; Spyros Karkabounas
Journal: Bioinorganic Chemistry and Applications
 (2008)

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## Abstract

A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)3Sn(TBA)⋅H2O] (1) has been synthesized and characterized by elemental analysis and 119Sn-NMR
and FT-IR spectroscopic techniques. The crystal structure of
complex 1
has been determined by single crystal X-ray diffraction analysis
at 120(2) K. The geometry around Sn(IV) is trigonal
bipyramidal. Three n-butyl
groups and one oxygen atom from a deprotonated 2-thiobarbituric
ligand are bonded to the metal center. The geometry is completed
with one oxygen from a water molecule. Compound 1 exhibits potent, in
vitro, cytotoxicity against sarcoma cancer cells (mesenchymal
tissue) from the Wistar rat, polycyclic aromatic hydrocarbons
(PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhibition
caused by 1, in the rate of
lipoxygenase (LOX) catalyzed oxidation
reaction of linoleic acid to hyperoxolinoleic acid, has been also
kinetically and theoretically studied. The results are compared to
that of cisplatin.


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## Body


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*Source: 654137-2008-04-06.xml*