# A Systematic Literature Review on Particle Swarm Optimization Techniques for Medical Diseases Detection

Authors: Sobia Pervaiz; Zia Ul-Qayyum; Waqas Haider Bangyal; Liang Gao; Jamil Ahmad
Journal: Computational and Mathematical Methods in Medicine
 (2021)

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## Abstract

Artificial Intelligence (AI) is the domain of computer science that focuses on the development of machines that operate like humans. In the field of AI, medical disease detection is an instantly growing domain of research. In the past years, numerous endeavours have been made for the improvements of medical disease detection, because the errors and problems in medical disease detection cause serious wrong medical treatment. Meta-heuristic techniques have been frequently utilized for the detection of medical diseases and promise better accuracy of perception and prediction of diseases in the domain of biomedical. Particle Swarm Optimization (PSO) is a swarm-based intelligent stochastic search technique encouraged from the intrinsic manner of bee swarm during the searching of their food source. Consequently, for the versatility of numerical experimentation, PSO has been mostly applied to address the diverse kinds of optimization problems. However, the PSO techniques are frequently adopted for the detection of diseases but there is still a gap in the comparative survey. This paper presents an insight into the diagnosis of medical diseases in health care using various PSO approaches. This study presents to deliver a systematic literature review of current PSO approaches for knowledge discovery in the field of disease detection. The systematic analysis discloses the potential research areas of PSO strategies as well as the research gaps, although, the main goal is to provide the directions for future enhancement and development in this area. This paper gives a systematic survey of this conceptual model for the advanced research, which has been explored in the specified literature to date. This review comprehends the fundamental concepts, theoretical foundations, and conventional application fields. It is predicted that our study will be beneficial for the researchers to review the PSO algorithms in-depth for disease detection. Several challenges that can be undertaken to move the field forward are discussed according to the current state of the PSO strategies in health care.


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## Body

## 1. Introduction

The application of computational intelligence for diagnosis of medical diseases has become a new trend in recent years. Numerous methods of medical disease diagnosis can be grouped as intelligent data classification tasks. In terms of the total number of groups that are continuously distributed, the classification techniques may are divided into two categories. The first classification distribution is Binary Classification (Two-class task), which differentiates the data solely between two classes. The second classification is Multi-Classification (multi-class task), which distinguishes data from more than two classes [1, 2]. Several scientists and researchers in the medical domain have experimented with different techniques to improve the authenticity (accuracy) of data classification. Recently, State-of-the-Art algorithms such as Tabu Search, Genetic algorithm (GA), Bat Algorithm (BA) [3] and PSO, as well as, data mining tools like, Decision Tree and Neural Networks have been utilized in this domain, where these approaches have produced remarkable results [4].Excluding the other standard classification complexities, the classifications of medical datasets furthermore are employed in disease detection. Consequently, doctors or patients must not only observe the classification findings that have been evaluated but also be familiar with the symptoms that have been used for the classification purpose. Linear programming [5] models and Neural Networks (NN) [6, 7] have been presented for the solution of such kinds of problems. However, the decision methods of such classification models are a black box, which had not provided any explanation related to the attainment of results. Similarly, the hybrid approaches like NN or GA that contain fuzzy rules have handled the issues resulting from black box techniques, although, they were still unable to recognize the input factors that are more suitable than others.Many researchers in the literature have used PSO state-of-the-art algorithm to solve this problem by embedding various other approaches such as a random forest with PSO [8] and K-nearest neighbour with PSO [9, 10] etc. Our contribution in this study is to provide a comprehensive Systematic Literature Review (SLR) on the PSO and its variants for the detection of medical diseases. This study is being conducted on the basis of a particular time duration, in which the articles are collected from 2010 to 2020. The primary objective of this research is to give a baseline for the researchers who are intended to research the detection of medical diseases with the help of PSO and its improved approaches. Similarly, our work presents a detailed discussion on the past literature, as well as, describes the future directions for the scientist of this field.The structure of this SLR is organized in the following way: A primary study related to the utilization of PSO for medical disease detection is presented in Section2. The Systematic Review methodology for this SLR is explained in Section 3. Section 4 is illustrating the Research Planning of our study. In Section 5, the detailed discussion on the Execution Plan of this study is demonstrated. However, Section 6 is representing the Results of our work, while Section 7 provides the conclusion of this SLR.


## 2. Primary Studies

For diagnosis the Alzheimer’s disease (AD), a novel method is introduced in [11] that is based on magnetic resonance imaging (MRI) images pre-processing, principal component analysis, feature extraction, and support vector machine (SVM) model. To optimize the parameters of SVM a novel switching delayed particle swarm optimization (SDPSO) is introduced. The introduced SDPSO-SVM method is successfully tested on the ADNI dataset for the classification of AD. The introduced algorithm achieved higher classification accuracy on 6 standard cases. Moreover, the test results conclude that the introduced method is serving as the most effective approach for diagnosis the AD.A novel PSO and Artificial Neural Network (PSO-ANN) based model is developed for diagnosing dengue fever at an early stage [12]. In the introduced model, the PSO approach is incorporated to optimize the bias and weight factors of the ANN approach. The performance of the introduced model is examined through the sensitivity, error rate, accuracy, specificity, and area under the curve (AUC) parameters. The results of the proposed model are compared with other traditional approaches such as Decision Tree (DT), PSO, Naive Bayes (NB), and ANN. It is monitored that the proposed model is powerful and proficient for the detection of dengue fever at an early stage.A novel machine learning model is developed for the detection of AD from brain MRI [13]. At first, the image was processed. Second, the texture features were extracted. Third, for the classification, a single-layer neural network was selected. At last, a novel approach predator-prey PSO is proposed for adjusting the biases and weights of ANN. In terms of efficiency, the proposed method outperforms 10 state-of-the-art approaches, as well as, better than the human observers to diagnose AD.An extended ANN approach termed Optimized Artificial Neural Network (OANN) is proposed and implemented on medical datasets to diagnose heart disease [14]. For reducing the disease dimension, an Optimized PSO technique is applied. Furthermore, the filter-based ANN is used for binary classification (as positive or negative) of disease according to the disease feature. The proficiency of the proposed approach is measured by comparing with the traditional methods’ performance plot, ROC values, confusion matrix, and Regression. It is observed that after embedding the proposed PSO with ANN for feature reduction, the effectiveness of the introduced model is optimized.Two novel modified Boolean PSO are introduced named Improved Velocity Bounded BoPSO (IVbBoPSO) and Velocity Bounded BoPSO (IVbBoPSO) to figure out the feature selection challenges, while diagnosing kidney and liver cancer [15]. In modified versions, the parameter Vmin is introduced for the feature selection problem. The accuracy of modified versions is evaluated on twenty-eight classical functions selected from CEC 2013, as well as, tested for feature selection through a disease diagnostic system. The statistical results conclude that the modified versions outperform to achieve the maximum classification accuracy.In [8], a Random Forest (RF) approach is used with PSO (RF + PSO) for the detection of lymph diseases. The approach is split into two phases: the initial phase is for feature selection, where PSO and other feature selection methods are applied for selecting discriminative features; the second phase is for classification, where RF ensemble is utilized to carry out the classification for detection of lymph diseases. In the process of feature selection, the initial and resampled partitions of datasets are used to train the RF classifier. The simulation results illustrate that the proposed approach is superior based on the accuracy rate.A novel approach Block-Based Neural Network (BBNN) using PSO is introduced for the classification of Electrocardiogram signals (ECG) [16]. The PSO algorithm is incorporated for optimizing the network structure and weights. The parameters of BBNN are optimized with the help of a PSO algorithm that can reduce the probable alterations of ECG signals with the variation of time and/or person. The performance of the introduced approach is measured by using the database of MIT-BIH arrhythmia, where the results show 97% classification accuracy.


## 3. Systematic Review Methodology

This research applied the systematic review methodology of Brereton et al. [17], which provides a reliable and precise analysis of research that is conducted through a particular topic. This sort of inspection provides the overview of evidence with the help of coherent systematic search techniques and the synthesis of elected records [18]. Furthermore, this method has been extensively used in [17–20]. However, our work is established on the ground of earlier literature, which describes that the process should be classified into three phases: First is planning, second is conducting and third is an analysis of results. Thus, the later sections explain that how we addressed these three phases.


## 4. Research Planning

The planning phase discussed the scientific research questions definition, identification of databases, definition of keywords, searching techniques, standards for include & exclude, and quality of article [17–20]. Thus, the following research questions (RQn) were identified on the basis of challenges:


### 4.1. Research Questions

RQ1: What is the brief overview of current research?RQ2: What are the extensively applied approaches?RQ3: How the work is distributed according to time division?RQ4: Which research papers are frequently cited?RQ5: What are the diseases and algorithms are used?RQ6: What are the research possibilities?Generally, include, exclude and quality standards are defined next to the explanation of research questions [21]. Therefore, Table 1 describes the requirements that are used in this research.Table 1
Include, Exclude and Quality Standards.
RequirementsIncludeLiterature in English.Methodology papers, journal articles or conferences.Literature relevant to the medical diseases diagnosis by using PSO techniques.ExcludeStudies that are not proficient according to quality standards.Papers that are irrelevant from the road map.Literature published in another language rather than English.Literature issued before 2010.QualityResearch with various proposals.The goal of this process may be to examine the judgments related to the type of reconsiderations that should be studied in this research, which are applied to the sub-categories of primary studies for directing the selection criteria [18, 22]. As a consequence, each searched article will be examined with respect to title, abstract, keywords, proposed techniques, results, and conclusions in order to verify the worth of this review. Similarly, the following digital databases are utilized for searching the papers in this article.
(i)
Digital Library of IEEE(ii)
Electronic Library ACM(iii)
Google Scholars(iv)
Springer Link(v)
Elsevier Science Direct(vi)
Semantic Scholars(vii)
EmeraldFinally, the Boolean recovery approach was used to search literature from the aforementioned databases. Fundamentally, it splits the search space and defines the sub-category of the document, as stated in the criteria of consultation [23]. In our work, the following combination of strings provide us the solution: ((“Particle Swam Optimization” OR“PSO” OR “Swarm Intelligence” OR “Bio-inspired PSO Algorithm” OR “Meta-Heuristic Algorithm PSO” OR “Nature-inspired Algorithm PSO” OR “Evolutionary Computing Algorithm PSO”) AND (“Medical Disease Diagnosis” OR “Medical Diseases Diagnosis” OR “Medical Disease Detection” OR “Medical Diseases Detection” OR “Medical Disorder Diagnosis” OR “Medical Disorder Detection” OR “Health-Care”)).


## 4.1. Research Questions

RQ1: What is the brief overview of current research?RQ2: What are the extensively applied approaches?RQ3: How the work is distributed according to time division?RQ4: Which research papers are frequently cited?RQ5: What are the diseases and algorithms are used?RQ6: What are the research possibilities?Generally, include, exclude and quality standards are defined next to the explanation of research questions [21]. Therefore, Table 1 describes the requirements that are used in this research.Table 1
Include, Exclude and Quality Standards.
RequirementsIncludeLiterature in English.Methodology papers, journal articles or conferences.Literature relevant to the medical diseases diagnosis by using PSO techniques.ExcludeStudies that are not proficient according to quality standards.Papers that are irrelevant from the road map.Literature published in another language rather than English.Literature issued before 2010.QualityResearch with various proposals.The goal of this process may be to examine the judgments related to the type of reconsiderations that should be studied in this research, which are applied to the sub-categories of primary studies for directing the selection criteria [18, 22]. As a consequence, each searched article will be examined with respect to title, abstract, keywords, proposed techniques, results, and conclusions in order to verify the worth of this review. Similarly, the following digital databases are utilized for searching the papers in this article.
(i)
Digital Library of IEEE(ii)
Electronic Library ACM(iii)
Google Scholars(iv)
Springer Link(v)
Elsevier Science Direct(vi)
Semantic Scholars(vii)
EmeraldFinally, the Boolean recovery approach was used to search literature from the aforementioned databases. Fundamentally, it splits the search space and defines the sub-category of the document, as stated in the criteria of consultation [23]. In our work, the following combination of strings provide us the solution: ((“Particle Swam Optimization” OR“PSO” OR “Swarm Intelligence” OR “Bio-inspired PSO Algorithm” OR “Meta-Heuristic Algorithm PSO” OR “Nature-inspired Algorithm PSO” OR “Evolutionary Computing Algorithm PSO”) AND (“Medical Disease Diagnosis” OR “Medical Diseases Diagnosis” OR “Medical Disease Detection” OR “Medical Diseases Detection” OR “Medical Disorder Diagnosis” OR “Medical Disorder Detection” OR “Health-Care”)).


## 5. Execution Plan

This phase implies five steps: (1) implements the search in the preferred database; (2) correlate the search results for excluding the duplicated articles; (3) apply the include, exclude, and quality standards; (4) assessment of all articles that accepted in the preliminary study; (5) data formation [17, 18].Figure1 illustrates the sequence of our systematic literature review. Initially, the first step was established to run the search queries in all elected databases that identified an extensive set of 1490 articles. Subsequently, the literature issued before 2010 was discarded, which returned 970 papers.Figure 1
Research Flow of Systematic Literature Review.However, to purify the search and discard the papers that were irreverent according to the scope of this review, a precise investigation was employed on the titles, keywords, and abstracts with respect to the exclude standards (Table1). It excluded 916 articles and returned a pre-screening collection of 54 papers for quality inspection. It is crucial to highlight that the queries which returned numerous papers using keywords, were inappropriate for the scope of this research; this defends the total numbers of excluded papers.Finally, a formation (synthesis) was performed to research under the aforementioned quality criteria. As a result, 11 of the 54 publications were eliminated due to quality issues, leaving a final collection of 43 publications with important information on Particle Swarm Optimization for medical disease diagnosis.


## 6. Result

The results of SLR are discussed in this section. Thereby, each sub-section will demonstrate the challenges, which are addressed at the start of this research.


### 6.1. RQ1: Brief Overview of Ongoing Research

The selected literature for this SLR is illustrated in Table2. By analyzing the selected literature, we will reveal the present review (overview) of the meta-heuristic PSO algorithm for medical disease detection. Accordingly, to present an overview of the various issues that have been presented in selected literature, they were grouped into ten categories.
(i)
Heart Disease(ii)
Dental Disease(iii)
Lymphatic Diseases(iv)
Celiac Disease (CD)(v)
Liver Disease(vi)
Cancer Disease(vii)
Brain Disease(viii)
Hepatitis Disease(ix)
Diabetes(x)
OthersTable 2
Selected Literature (ID and References).
IDReference1[24]2[25]3[26]4[8]5[16]6[27]7[28]8[29]9[30]10[31]11[32]12[33]13[34]14[35]15[36]16[37]17[38]18[2]19[39]20[40]21[41]22[9]23[24]24[42]25[43]26[44]27[45]28[11]29[12]30[13]31[14]32[15]33[46]34[47]35[48]36[49]37[50]38[51]39[52]40[53]41[54]42[55]43[56]The objective of this study is to find out the PSO techniques that are used to detect the below-mentioned categorized diseases. The concerned topic of diseases and the research papers which are used in the particular diseases are displayed in Table3.Table 3
Concerned Topic of Diseases.
Sr. noConcerned topicReference1Heart disease[9, 16, 24, 25, 28, 30, 32, 33, 37, 39, 42, 43, 46, 48, 50, 51, 53, 54, 57]2Dental disease[26]3Lymphatic diseases[8, 55]4Celiac disease (CD)[27]5Liver disease[2, 15, 24, 29, 34, 51, 52, 55]6Cancer disease[2, 15, 24, 30–32, 34, 44, 51, 53, 55, 56]7Brain disease[11, 13, 24, 34–36, 38, 41, 44, 45, 47, 51, 55]8Hepatitis disease[30, 40, 51, 56]9Diabetes[24, 30, 48, 49, 51, 53, 55, 56]10Others[12, 51, 53]


### 6.2. RQ2: Extensively Used Approaches

A cloud of words is illustrated in Figure2, in which the size of each term demonstrates the number of their occurrence. This word cloud is generated on the basis of terms enclosed in the titles of selected research articles. The supremacy of terms indicates that these are the frequently adopted techniques of PSO and medical diseases, which are applied to develop computational intelligent models for disease detection. According to the size of terms in Figure 2, it can be observed that Particle Swarm Optimization, Medical Disease Detection, and PSO algorithm are the predominant words that frequently appear in the targeted research articles.Figure 2
Frequently Occurred Words in Selected Literature.


### 6.3. RQ3: Literature Distribution with Time Division

The evaluation related to the Distribution of selected literature with respect to the time division is presented in Figure3. The distribution can be analyzed through Figure 3, which shows that the years 2012 and 2016 recorded the topmost portion/quantity of research articles, with 18 articles (9 in each year), representing 41.86% of the published literature. Similarly, the years 2014 and 2015 published the same counts of articles, 5 in each that covers 23.25% portion of selected literature. The same is the situation with years 2013 and 2017, these years published a total of 8 papers, 4 every year that fills 18.60% section of the literature. However, the year 2011 released 3 (6.97%) papers, besides this, the years 2010 and 2018 issued only 4 articles (2 in each year) that satisfy an 18.60% segment of the selected literature. Hence, there is zero publications in the year 2019 and 2020 related to our study.Figure 3
Temporal Distribution of Literature.


### 6.4. RQ4: Frequently Cited Research Papers

The total citations of elected top 12 papers from literature are identified as 1193 on the topic of PSO techniques and medical diseases, which can be review in Table4. Abdulhamit Subasi [37] published his research in the Journal of Computer in Biology and Medicine that was the highest cited (343 citations) research article. The rest of the articles are issued in the following Journals: Applied Soft Computing ([56], 139 citations), Expert Systems with Applications ([39], 136 citations), International Journal of neural systems ([44], 110 citations), Neurocomputing ([11], 76 citations), Biomedical Signal Processing and Control ([16], 70), Neural Computing and Applications ([24], 60 citations), Computer methods and programs in biomedicine ([2], 58 citations), Expert Systems with Applications ([15], 55), Journal of Alzheimer’s Disease ([13], 51 citations), Soft Computing ([51], 48 citations) and ISRN Artificial Intelligence ([40], 47 citations).Table 4
Top 12 Cited Research Articles.
ReferencePaper titleYear of publicationCitations[37]Classification of EMG signals using PSO optimized SVM for diagnosis of neuromuscular disorders2013343[56]Radial basis function network based on time variant multi-objective particle swarm optimization for medical diseases diagnosis2011139[39]A hybrid particle swarm optimization based fuzzy expert system for the diagnosis of coronary artery disease2012136[44]Prediction of Parkinson’s disease tremor onset using a radial basis function neural network based on particle swarm optimization2010110[11]A new switching-delayed-PSO-based optimized SVM algorithm for diagnosis of Alzheimer’s disease201876[16]A new personalized ECG signal classification algorithm using block-based neural network and particle swarm optimization201670[24]Particle swarm optimization for feature selection with application in obstructive sleep apnea diagnosis201260[2]An attribute weight assignment and particle swarm optimization algorithm for medical database classifications201258[15]Velocity bounded Boolean particle swarm optimization for improved feature selection in liver and kidney disease diagnosis201655[13]Multivariate approach for Alzheimer’s disease detection using stationary wavelet entropy and predator-prey particle swarm optimization201851[51]Enhancement of artificial neural network learning using centripetal accelerated particle swarm optimization for medical diseases diagnosis201448[40]Hepatitis disease diagnosis using hybrid case based reasoning and particle swarm optimization201247


### 6.5. RQ5: Utilized Medical Diseases and Algorithms

In this question, we describe a concise explanation of medical diseases and the variants of PSO that are utilized for disease detection in the selected articles for this SLR. The comparative description of medical diseases and variants of PSO can be seen in Table5. In Table 5, each tuple is representing the papers that used the particular variant of PSO for a specific type of disease detection. It can be analyzed from Table 5 that the majority of researchers applied Standard PSO and Improved versions of PSO that are as follows: Switching delayed PSO [11], Predator-prey PSO [13], Velocity Bounded BoPSO (VbBoPSO) & Improved Velocity Bounded BoPSO (IVbBoPSO) [15], Modified PSO [49], Dynamic multi-swarm particle swarm optimizer DMS-PSO [50], Centripetal accelerated PSO (CAPSO) [51], Binary PSO (BPSO) [52, 53] and Time variant multi-objective PSO (TVMOPSO) [56]. Similarly, it can be examined from Table 5 that the researchers in the literature focused on the following diseases: Heart (detection of Coronary Heart Disease (CHD), ECG heartbeats, cardiovascular, HeartStatlog, Cleveland Heart Disease, SPECT heart, SPECTF heart, cardiac arrhythmia, and Diabetic Cardiomyopathy), Brain (Alzheimer’s disease (AD), Parkinson’s disease, Mild Cognitive Impairment (MCI) and Brain Abnormalities), Caner (breast cancer, Liver Cancer and Kidney Cancer), Liver, Diabetes, and Hepatitis, etc. Other than this, the hybridization of PSO and PSO with NN are very few that were incorporated for the detection of medical diseases. Additionally, Celiac and Lymphatic diseases are also miner in numbers that were used in the past study for the objective of disease detection by using PSO’s techniques.Table 5
Classification of Concerned Topics regarding PSO’s Technique.
Theme/variants of PSOStandard PSOPSO with neural networkImproved/extended PSOHybridized PSOHeart disease[9, 16, 24, 25, 30, 32, 33, 37, 39, 42, 43, 57][14, 28][50, 51, 53, 54][46, 48]Dental disease[26]———Lymphatic disease[8]—[55]—Celiac disease[27]———Liver disease[2, 24, 29, 34]—[51, 52, 55]—Cancer disease[2, 24, 30–32, 34]—[15, 51, 53, 55, 56]—Brain disease[24, 34–36, 38, 41, 44, 45]—[11, 13, 51, 55][47]Hepatitis disease[30, 40]—[51, 56]—Diabetes[24, 30]—[49, 51, 53, 55, 56]—Others—[12][53]—


### 6.6. RQ6: Research Possibilities

This domain further has numerous branches that need to be investigated. Hence, in Table6, we outlined the improved variants of PSO that could be utilized for disease detection in the medical field. In addition to this, we attached the hot topics of diseases that need to get the focus of researchers, while applying PSO’s techniques for the field of disease detection can be observed in Table 7. The fundamental objective of these tables is to reveal the feasible gaps (holes) and forthcoming works that should be considered. There are well-defined gaps to be examined since, reviewing the high qualified works published from 2010 to 2010. A small number of areas have been investigated in literature while multiple medical domains could contribute from the improved variants of PSO like Gastric, Lungs, Ankle, Eye, Prostitute, SARS, Covid-19, etc. Furthermore, due to the trend of medical disease detection, there is a quite large number of fields to be reviewed. For this reason, a group of open hypotheses is given that could be investigated in future works for the researchers who are intended to contribute to the society of these thematic areas. Concluding this, it is essential to highlight the purpose of this section, which was to declare the themes and to underline certain hypotheses on the basis of SLR for future research.Table 6
Improved Variants of PSO for Future work.
Sr no.TitleYearReference1Particle swarm optimization using Sobol mutation2008[58]2A new hybrid MGBPSO-GSA variant for improvingFunction optimization solution in search space2017[59]3Multi-leader PSO (MLPSO): A new PSO variant forSolving global optimization problems2017[60]4Phasor particle swarm optimization: a simple and efficient variant of PSO2019[61]5An improved particle swarm optimizationAlgorithm with Chi-Square mutation strategy2019[62]Table 7
List of Diseases need to apply in Future works.
Sr no.TitleYearReference1Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): The epidemic and the challenges2020[63]2A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice2007[64]3The definition \& classification of dry eye disease2008[65]4Ankle disease in juvenile idiopathic arthritis: Ultrasound findings in clinically swollen ankles2009[66]5Hydatid disease of the lungs1992[67]


## 6.1. RQ1: Brief Overview of Ongoing Research

The selected literature for this SLR is illustrated in Table2. By analyzing the selected literature, we will reveal the present review (overview) of the meta-heuristic PSO algorithm for medical disease detection. Accordingly, to present an overview of the various issues that have been presented in selected literature, they were grouped into ten categories.
(i)
Heart Disease(ii)
Dental Disease(iii)
Lymphatic Diseases(iv)
Celiac Disease (CD)(v)
Liver Disease(vi)
Cancer Disease(vii)
Brain Disease(viii)
Hepatitis Disease(ix)
Diabetes(x)
OthersTable 2
Selected Literature (ID and References).
IDReference1[24]2[25]3[26]4[8]5[16]6[27]7[28]8[29]9[30]10[31]11[32]12[33]13[34]14[35]15[36]16[37]17[38]18[2]19[39]20[40]21[41]22[9]23[24]24[42]25[43]26[44]27[45]28[11]29[12]30[13]31[14]32[15]33[46]34[47]35[48]36[49]37[50]38[51]39[52]40[53]41[54]42[55]43[56]The objective of this study is to find out the PSO techniques that are used to detect the below-mentioned categorized diseases. The concerned topic of diseases and the research papers which are used in the particular diseases are displayed in Table3.Table 3
Concerned Topic of Diseases.
Sr. noConcerned topicReference1Heart disease[9, 16, 24, 25, 28, 30, 32, 33, 37, 39, 42, 43, 46, 48, 50, 51, 53, 54, 57]2Dental disease[26]3Lymphatic diseases[8, 55]4Celiac disease (CD)[27]5Liver disease[2, 15, 24, 29, 34, 51, 52, 55]6Cancer disease[2, 15, 24, 30–32, 34, 44, 51, 53, 55, 56]7Brain disease[11, 13, 24, 34–36, 38, 41, 44, 45, 47, 51, 55]8Hepatitis disease[30, 40, 51, 56]9Diabetes[24, 30, 48, 49, 51, 53, 55, 56]10Others[12, 51, 53]


## 6.2. RQ2: Extensively Used Approaches

A cloud of words is illustrated in Figure2, in which the size of each term demonstrates the number of their occurrence. This word cloud is generated on the basis of terms enclosed in the titles of selected research articles. The supremacy of terms indicates that these are the frequently adopted techniques of PSO and medical diseases, which are applied to develop computational intelligent models for disease detection. According to the size of terms in Figure 2, it can be observed that Particle Swarm Optimization, Medical Disease Detection, and PSO algorithm are the predominant words that frequently appear in the targeted research articles.Figure 2
Frequently Occurred Words in Selected Literature.


## 6.3. RQ3: Literature Distribution with Time Division

The evaluation related to the Distribution of selected literature with respect to the time division is presented in Figure3. The distribution can be analyzed through Figure 3, which shows that the years 2012 and 2016 recorded the topmost portion/quantity of research articles, with 18 articles (9 in each year), representing 41.86% of the published literature. Similarly, the years 2014 and 2015 published the same counts of articles, 5 in each that covers 23.25% portion of selected literature. The same is the situation with years 2013 and 2017, these years published a total of 8 papers, 4 every year that fills 18.60% section of the literature. However, the year 2011 released 3 (6.97%) papers, besides this, the years 2010 and 2018 issued only 4 articles (2 in each year) that satisfy an 18.60% segment of the selected literature. Hence, there is zero publications in the year 2019 and 2020 related to our study.Figure 3
Temporal Distribution of Literature.


## 6.4. RQ4: Frequently Cited Research Papers

The total citations of elected top 12 papers from literature are identified as 1193 on the topic of PSO techniques and medical diseases, which can be review in Table4. Abdulhamit Subasi [37] published his research in the Journal of Computer in Biology and Medicine that was the highest cited (343 citations) research article. The rest of the articles are issued in the following Journals: Applied Soft Computing ([56], 139 citations), Expert Systems with Applications ([39], 136 citations), International Journal of neural systems ([44], 110 citations), Neurocomputing ([11], 76 citations), Biomedical Signal Processing and Control ([16], 70), Neural Computing and Applications ([24], 60 citations), Computer methods and programs in biomedicine ([2], 58 citations), Expert Systems with Applications ([15], 55), Journal of Alzheimer’s Disease ([13], 51 citations), Soft Computing ([51], 48 citations) and ISRN Artificial Intelligence ([40], 47 citations).Table 4
Top 12 Cited Research Articles.
ReferencePaper titleYear of publicationCitations[37]Classification of EMG signals using PSO optimized SVM for diagnosis of neuromuscular disorders2013343[56]Radial basis function network based on time variant multi-objective particle swarm optimization for medical diseases diagnosis2011139[39]A hybrid particle swarm optimization based fuzzy expert system for the diagnosis of coronary artery disease2012136[44]Prediction of Parkinson’s disease tremor onset using a radial basis function neural network based on particle swarm optimization2010110[11]A new switching-delayed-PSO-based optimized SVM algorithm for diagnosis of Alzheimer’s disease201876[16]A new personalized ECG signal classification algorithm using block-based neural network and particle swarm optimization201670[24]Particle swarm optimization for feature selection with application in obstructive sleep apnea diagnosis201260[2]An attribute weight assignment and particle swarm optimization algorithm for medical database classifications201258[15]Velocity bounded Boolean particle swarm optimization for improved feature selection in liver and kidney disease diagnosis201655[13]Multivariate approach for Alzheimer’s disease detection using stationary wavelet entropy and predator-prey particle swarm optimization201851[51]Enhancement of artificial neural network learning using centripetal accelerated particle swarm optimization for medical diseases diagnosis201448[40]Hepatitis disease diagnosis using hybrid case based reasoning and particle swarm optimization201247


## 6.5. RQ5: Utilized Medical Diseases and Algorithms

In this question, we describe a concise explanation of medical diseases and the variants of PSO that are utilized for disease detection in the selected articles for this SLR. The comparative description of medical diseases and variants of PSO can be seen in Table5. In Table 5, each tuple is representing the papers that used the particular variant of PSO for a specific type of disease detection. It can be analyzed from Table 5 that the majority of researchers applied Standard PSO and Improved versions of PSO that are as follows: Switching delayed PSO [11], Predator-prey PSO [13], Velocity Bounded BoPSO (VbBoPSO) & Improved Velocity Bounded BoPSO (IVbBoPSO) [15], Modified PSO [49], Dynamic multi-swarm particle swarm optimizer DMS-PSO [50], Centripetal accelerated PSO (CAPSO) [51], Binary PSO (BPSO) [52, 53] and Time variant multi-objective PSO (TVMOPSO) [56]. Similarly, it can be examined from Table 5 that the researchers in the literature focused on the following diseases: Heart (detection of Coronary Heart Disease (CHD), ECG heartbeats, cardiovascular, HeartStatlog, Cleveland Heart Disease, SPECT heart, SPECTF heart, cardiac arrhythmia, and Diabetic Cardiomyopathy), Brain (Alzheimer’s disease (AD), Parkinson’s disease, Mild Cognitive Impairment (MCI) and Brain Abnormalities), Caner (breast cancer, Liver Cancer and Kidney Cancer), Liver, Diabetes, and Hepatitis, etc. Other than this, the hybridization of PSO and PSO with NN are very few that were incorporated for the detection of medical diseases. Additionally, Celiac and Lymphatic diseases are also miner in numbers that were used in the past study for the objective of disease detection by using PSO’s techniques.Table 5
Classification of Concerned Topics regarding PSO’s Technique.
Theme/variants of PSOStandard PSOPSO with neural networkImproved/extended PSOHybridized PSOHeart disease[9, 16, 24, 25, 30, 32, 33, 37, 39, 42, 43, 57][14, 28][50, 51, 53, 54][46, 48]Dental disease[26]———Lymphatic disease[8]—[55]—Celiac disease[27]———Liver disease[2, 24, 29, 34]—[51, 52, 55]—Cancer disease[2, 24, 30–32, 34]—[15, 51, 53, 55, 56]—Brain disease[24, 34–36, 38, 41, 44, 45]—[11, 13, 51, 55][47]Hepatitis disease[30, 40]—[51, 56]—Diabetes[24, 30]—[49, 51, 53, 55, 56]—Others—[12][53]—


## 6.6. RQ6: Research Possibilities

This domain further has numerous branches that need to be investigated. Hence, in Table6, we outlined the improved variants of PSO that could be utilized for disease detection in the medical field. In addition to this, we attached the hot topics of diseases that need to get the focus of researchers, while applying PSO’s techniques for the field of disease detection can be observed in Table 7. The fundamental objective of these tables is to reveal the feasible gaps (holes) and forthcoming works that should be considered. There are well-defined gaps to be examined since, reviewing the high qualified works published from 2010 to 2010. A small number of areas have been investigated in literature while multiple medical domains could contribute from the improved variants of PSO like Gastric, Lungs, Ankle, Eye, Prostitute, SARS, Covid-19, etc. Furthermore, due to the trend of medical disease detection, there is a quite large number of fields to be reviewed. For this reason, a group of open hypotheses is given that could be investigated in future works for the researchers who are intended to contribute to the society of these thematic areas. Concluding this, it is essential to highlight the purpose of this section, which was to declare the themes and to underline certain hypotheses on the basis of SLR for future research.Table 6
Improved Variants of PSO for Future work.
Sr no.TitleYearReference1Particle swarm optimization using Sobol mutation2008[58]2A new hybrid MGBPSO-GSA variant for improvingFunction optimization solution in search space2017[59]3Multi-leader PSO (MLPSO): A new PSO variant forSolving global optimization problems2017[60]4Phasor particle swarm optimization: a simple and efficient variant of PSO2019[61]5An improved particle swarm optimizationAlgorithm with Chi-Square mutation strategy2019[62]Table 7
List of Diseases need to apply in Future works.
Sr no.TitleYearReference1Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): The epidemic and the challenges2020[63]2A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice2007[64]3The definition \& classification of dry eye disease2008[65]4Ankle disease in juvenile idiopathic arthritis: Ultrasound findings in clinically swollen ankles2009[66]5Hydatid disease of the lungs1992[67]


## 7. Conclusion

PSO has been widely adopted to solve real-world nonlinear complex optimization problems in various areas. This study is shown a systematic review of existing studies on the standard PSO and its variants to diagnose the medical diseases for health care. Researchers have been suggested various PSO variants for medical disease diagnosis in health care, although, PSO still requires an extreme inspection to enhance its performance. The paper is giving detail on different medical diseases that have been utilized in numerous PSO approaches for solving medical disease detection in health care. We tried to give a systematic survey of various medical diseases and analyzed each PSO technique separately. In order to perform the systematic survey, the gaps in the literature are figured out and converted into six research questions. For the next stage, the research questions are taken into account for analysis, where the following points are briefly explained: the utilization of PSO and its variants in diseases detection, the worth of selected articles, the time division of published articles, generally encountered medical diseases, maximum applied PSO variants for disease detection. With the proper rate of growth in the research area, it is expected that additional work should be achieved in the future. The findings of this systematic survey depict that many researchers incorporated PSO and its variants to detect Heart disease, Cancer disease, Brain disease, Hepatitis disease, and Diabetes. Furthermore, the analytical results of the systematic survey illustrate that various scientists and researchers frequently targeted the Standard PSO and Improved versions of PSO for disease diagnosis. As the future direction, the researchers can utilize the improved versions of Neural Networks with PSO, as well as, can use the diverse hybridized versions of PSO for disease diagnosis. We anticipated that this survey will draw more attention to these problems and the substantial research will provide basic insight into how PSO mutation strategies enhance the performance of standard PSO in the health care domain. We are confident that such knowledge will encourage the PSO researchers to gain better awareness about a particular PSO, to enhance it, or to devise a new one.



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