# Clinical Effectiveness of Laparoscopic Fiberoptic Choledochoscopy versus Conventional Open Surgery for Gallbladder Stones Complicated with Common Bile Duct Stones

Authors: Ling Liu; Qiqi Guo; Weimin Shen
Journal: Evidence-Based Complementary and Alternative Medicine
 (2022)

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## Abstract

Objective. To assess the clinical effectiveness of laparoscopic fiberoptic choledochoscopy versus conventional open surgery for gallbladder stones complicated with common bile duct stones. Methods. In this retrospective study, 110 patients with gallbladder stones complicated with common bile duct stones treated in our institution between May 2018 and April 2020 were recruited and assigned to receive either open surgery (conventional group) or laparoscopic fiberoptic choledochoscopy (experimental group). Outcome measures included intraoperative indices, postoperative indices, postoperative complications, and changes in postoperative blood indices. Results. Laparoscopic fiberoptic choledochoscopy was associated with less intraoperative bleeding volume and a shorter surgical incision length versus open surgery (P<0.05). All eligible patients showed similar operative time (P>0.05). Laparoscopic fiberoptic choledochoscopy resulted in shorter postoperative exhaust time and mean length of stay and a higher mean hospitalization cost versus open surgery (P<0.05). There was no significant difference in the number of patients with intensive care units (ICU) monitoring or primary suture of the common bile duct between the two groups (P>0.05). The eligible patients after laparoscopic fiberoptic choledochoscopy experienced fewer complications versus those after open surgery (P<0.05). Laparoscopic fiberoptic choledochoscopy had a milder impact on postoperative albumin decrease versus open surgery (P<0.05). No significant difference was found in the postoperative leukocyte changes and total bilirubin decrease between the two groups (P>0.05). Conclusion. Laparoscopic fiberoptic choledochoscopy has better perioperative indices outcomes, lower incidence of postoperative complications, smaller postoperative albumin changes, and superior overall performance versus conventional open surgery for gallbladder stones complicated with common bile duct stones.


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## Body

## 1. Introduction

Gallbladder stones are a highly prevalent group of digestive disorders with a prevalence of about 15%. Gallbladder stones and common bile duct stones require effective treatment to relieve the symptoms [1]. Conventional open surgery, i.e., open cholecystectomy, common bile duct removal, and T-tube drainage, has been widely used as a mature procedure with a high success rate [2]. In recent years, it has been found that open surgery is associated with large incisions, high intraoperative bleeding, large postoperative scars, and poor postoperative recovery [3]. With the continuous development of medical technology, laparoscopic fiberoptic choledochoscopy has gained wide recognition, but further research is required to determine its ability to supersede conventional open surgery. Despite the established traditional surgical approach with a high success rate, laparoscopic fiberoptic choledochoscopy can remove more large stones and provide better biliary decompression with an indwelling T-tube, effectively avoiding or treating possible biliary pancreatitis or cholangitis, with short operative time, minimal scarring, rapid recovery, less adhesion formation, and low complication rate. Accordingly, this study was conducted to assess the clinical effectiveness of laparoscopic fiberoptic choledochoscopy versus conventional open surgery for gallbladder stones complicated with common bile duct stones.


## 2. Materials and Methods

### 2.1. Baseline Data

In this retrospective study, 110 patients with gallbladder stones complicated with common bile duct stones treated in our institution between May 2018 and April 2020 were recruited and assigned to either a conventional group (n = 47) or an experimental group (n = 63). The baseline characteristics of the conventional group (25 males and 22 females, aged 45–71 years, with a mean age of (60.24 ± 4.11) years, BMI of 20.4–24.9 kg/m2, with a mean BMI of (22.58 ± 1.02) kg/m2, duration of disease from 1 to 5 years, with a mean duration of disease of (2.45 ± 0.47) years, and preoperative common bile duct diameter from 1.5 cm to 2.5 cm, with a mean preoperative common bile duct diameter of (2.02 ± 0.24) cm) were comparable with those of the experimental group (33 males and 30 females, aged 43–70 years, with a mean age of (60.19 ± 4.39) years, BMI of 20.7–24.1 kg/m2, with a mean BMI of (22.61 ± 1.1) kg/m2, duration of disease from 2 to 6 years, with a mean duration of disease of (2.50 ± 0.42) years, and preoperative common bile duct diameter from 1.2 cm to 2.4 cm, with a mean preoperative common bile duct diameter of (2.05 ± 0.22) cm) (P>0.05).The studies involving human participants were reviewed and approved by our hospital, no. 7921937.


#### 2.1.1. Inclusion Criteria

All patients were diagnosed with common bile duct stones by clinical signs and symptoms and imaging examinations in our hospital and gave consent for surgical treatment; without obvious contraindications to anesthesia; met the indications for surgical treatment; all patients provided written informed consent for this experiment.


#### 2.1.2. Exclusion Criteria

Patients with severe organ dysfunction or insufficiency; with gallbladder polyps or other neoplastic diseases; with obvious acute obstructive purulent cholangitis lesions; with incomplete clinical data.


### 2.2. Methods

The conventional group was treated with traditional open surgery. Patients were given general anesthesia after tracheal intubation, followed by routine laparotomy and removal of the common bile duct after excision of the gallbladder. AT-tube of appropriate size was placed based on the diameter of the common bile duct, and the common bile duct incision was treated with interrupted sutures using 4-0 absorbable thread [4]. Water was perfused via a T-tube to determine the presence of a leak in the common bile duct and also the patency of the lower end of the common bile duct. The gallbladder bed was irrigated and observed for bleeding or bile leakage from the active area. After surgery, a laparoscopic drainage tube was placed under the patient’s liver and was secured with a T-tube through a port made on the lateral abdominal wall, and the incision was sutured layer by layer.The experimental group was given laparoscopic fiberoptic choledochoscopy. Patients were given general anesthesia after tracheal intubation, with the body tilted at 30° on the left side, and a four-port operative method was adopted. The patient’s abdominal cavity was first explored for ascites or abdominal adhesions, and after the successful removal of the gallbladder, the hepatoduodenal ligament was freed to fully expose the common bile duct. After the bile was extracted from the nonvascularized area of the anterior wall, a fiberoptic choledochoscope was placed under direct vision through a puncture hole between the subclavian poke and the subcostal margin poke in the midclavicular line, depending on the location of the common bile duct incision [5]. Small stones were removed directly from the common bile duct using a wire-guided basket, and large stones were treated with holmium laser lithotripsy by inserting a holmium laser fiber through the operating port using a transfiber choledochoscope, followed by removal of the stones using a wire-guided basket and preservation in a specimen bag. After irrigation, the common bile duct was reexamined to ensure no excess stones remain. A T-tube of appropriate diameter was placed into the common bile duct incision, and interrupted sutures were applied above and below the T-tube using 4-0 absorbable thread, after which the T-tube was led out of the abdominal wall and secured with sutures [6]. Liquid food was allowed after the first postoperative exhaustion. All patients were given postoperative general surgery care, the time of removal of the abdominal drainage tube was based on the amount of drainage, and antibiotics were routinely administered. T-tube imaging was performed 4–6 weeks after surgery, and patients were extubated 24 h afterward if no stones were found. The residual stones were removed through the sinus tract by fiberoptic choledochoscopy and removed with a wire-guided basket. Ultrasound or computed tomography was performed 6 months after surgery to identify any recurrence of stones, and the same method was used to remove the residual stones if the event of recurrence.In the early stage (6–12 h) after surgery, traditional Chinese medicine was used to treat the symptoms of qi stagnation and blood stasis, damp-heat and excessive toxin, and deficiency of qi and blood. The treatment should be based on promoting blood circulation and removing blood stasis, clearing away heat and dampness, detoxifying, promoting gallbladder, and relieving jaundice. The drug includes rhubarb, peach kernel, andCitrus aurantium each 12 g, Herba Artemisia scoparia, Christina Loosestrife herb, dandelion, and turmeric each 30 g, and raw mountain gardenia, Coptis chinensis, Salvia miltiorrhiza, and red peony root 15 g each. All the above were decocted to 100–200 mL to perform enema, once every 12 hours. 12 hours after the operation till drinking and eating, the intestines have been cleared, and the damp-heat is gradually receding, manifesting as deficiency of both qi and blood, liver stagnation, and qi stagnation, but still can be mixed with the signs of damp-heat internal accumulation, qi stagnation, and blood stasis. The treatment should be based on soothing the liver and gallbladder, regulating qi and promoting blood circulation, strengthening the root, and supporting the vitality. The drug includes Bupleurum, costus root, and licorice each 12 g, rhubarb, Scutellaria baicalensis, Pinellia chinensis, Citrus aurantium, and Evodia each 9 g, Gardenia jasminoides, Coptis chinensis, and Magnolia 9 g each, and Astragalus and Codonopsis 15 g each. All the above were first decocted with 500 mL of water for 30 min, and then, 150 mL of juice was extracted. Then, it was redecocted with 400 mL of water for 20 min, and then, 150 mL of juice was extracted. The two decoctions were mixed, one dose/d, taken in two servings.


### 2.3. Outcome Measure

Outcome measures included intraoperative indices, postoperative indices, postoperative complications, and changes in postoperative blood indices. Intraoperative indices included operative time, intraoperative bleeding volume, and operative incision length. Postoperative indices included postoperative exhaust time, number of patients in ICU care, the average length of hospital stay, average hospitalization cost, and primary suture of the common bile duct. Postoperative complications included wound infection, secondary pneumonia, abdominal abscess, biliary fistula, abdominal bleeding, and subdiaphragmatic pus accumulation. Postoperative blood indices included white blood cell changes, total bilirubin changes, and albumin changes at 24 h postoperatively.


### 2.4. Statistical Analysis

SPSS 18.0 was used for data analyses. The measurement data were expressed as (x¯ ± s) and processed using the t-test. The count data were expressed as the number of cases (rate) and processed using the chi-square test. Differences were considered statistically significant at P<0.05.


## 2.1. Baseline Data

In this retrospective study, 110 patients with gallbladder stones complicated with common bile duct stones treated in our institution between May 2018 and April 2020 were recruited and assigned to either a conventional group (n = 47) or an experimental group (n = 63). The baseline characteristics of the conventional group (25 males and 22 females, aged 45–71 years, with a mean age of (60.24 ± 4.11) years, BMI of 20.4–24.9 kg/m2, with a mean BMI of (22.58 ± 1.02) kg/m2, duration of disease from 1 to 5 years, with a mean duration of disease of (2.45 ± 0.47) years, and preoperative common bile duct diameter from 1.5 cm to 2.5 cm, with a mean preoperative common bile duct diameter of (2.02 ± 0.24) cm) were comparable with those of the experimental group (33 males and 30 females, aged 43–70 years, with a mean age of (60.19 ± 4.39) years, BMI of 20.7–24.1 kg/m2, with a mean BMI of (22.61 ± 1.1) kg/m2, duration of disease from 2 to 6 years, with a mean duration of disease of (2.50 ± 0.42) years, and preoperative common bile duct diameter from 1.2 cm to 2.4 cm, with a mean preoperative common bile duct diameter of (2.05 ± 0.22) cm) (P>0.05).The studies involving human participants were reviewed and approved by our hospital, no. 7921937.


### 2.1.1. Inclusion Criteria

All patients were diagnosed with common bile duct stones by clinical signs and symptoms and imaging examinations in our hospital and gave consent for surgical treatment; without obvious contraindications to anesthesia; met the indications for surgical treatment; all patients provided written informed consent for this experiment.


### 2.1.2. Exclusion Criteria

Patients with severe organ dysfunction or insufficiency; with gallbladder polyps or other neoplastic diseases; with obvious acute obstructive purulent cholangitis lesions; with incomplete clinical data.


## 2.1.1. Inclusion Criteria

All patients were diagnosed with common bile duct stones by clinical signs and symptoms and imaging examinations in our hospital and gave consent for surgical treatment; without obvious contraindications to anesthesia; met the indications for surgical treatment; all patients provided written informed consent for this experiment.


## 2.1.2. Exclusion Criteria

Patients with severe organ dysfunction or insufficiency; with gallbladder polyps or other neoplastic diseases; with obvious acute obstructive purulent cholangitis lesions; with incomplete clinical data.


## 2.2. Methods

The conventional group was treated with traditional open surgery. Patients were given general anesthesia after tracheal intubation, followed by routine laparotomy and removal of the common bile duct after excision of the gallbladder. AT-tube of appropriate size was placed based on the diameter of the common bile duct, and the common bile duct incision was treated with interrupted sutures using 4-0 absorbable thread [4]. Water was perfused via a T-tube to determine the presence of a leak in the common bile duct and also the patency of the lower end of the common bile duct. The gallbladder bed was irrigated and observed for bleeding or bile leakage from the active area. After surgery, a laparoscopic drainage tube was placed under the patient’s liver and was secured with a T-tube through a port made on the lateral abdominal wall, and the incision was sutured layer by layer.The experimental group was given laparoscopic fiberoptic choledochoscopy. Patients were given general anesthesia after tracheal intubation, with the body tilted at 30° on the left side, and a four-port operative method was adopted. The patient’s abdominal cavity was first explored for ascites or abdominal adhesions, and after the successful removal of the gallbladder, the hepatoduodenal ligament was freed to fully expose the common bile duct. After the bile was extracted from the nonvascularized area of the anterior wall, a fiberoptic choledochoscope was placed under direct vision through a puncture hole between the subclavian poke and the subcostal margin poke in the midclavicular line, depending on the location of the common bile duct incision [5]. Small stones were removed directly from the common bile duct using a wire-guided basket, and large stones were treated with holmium laser lithotripsy by inserting a holmium laser fiber through the operating port using a transfiber choledochoscope, followed by removal of the stones using a wire-guided basket and preservation in a specimen bag. After irrigation, the common bile duct was reexamined to ensure no excess stones remain. A T-tube of appropriate diameter was placed into the common bile duct incision, and interrupted sutures were applied above and below the T-tube using 4-0 absorbable thread, after which the T-tube was led out of the abdominal wall and secured with sutures [6]. Liquid food was allowed after the first postoperative exhaustion. All patients were given postoperative general surgery care, the time of removal of the abdominal drainage tube was based on the amount of drainage, and antibiotics were routinely administered. T-tube imaging was performed 4–6 weeks after surgery, and patients were extubated 24 h afterward if no stones were found. The residual stones were removed through the sinus tract by fiberoptic choledochoscopy and removed with a wire-guided basket. Ultrasound or computed tomography was performed 6 months after surgery to identify any recurrence of stones, and the same method was used to remove the residual stones if the event of recurrence.In the early stage (6–12 h) after surgery, traditional Chinese medicine was used to treat the symptoms of qi stagnation and blood stasis, damp-heat and excessive toxin, and deficiency of qi and blood. The treatment should be based on promoting blood circulation and removing blood stasis, clearing away heat and dampness, detoxifying, promoting gallbladder, and relieving jaundice. The drug includes rhubarb, peach kernel, andCitrus aurantium each 12 g, Herba Artemisia scoparia, Christina Loosestrife herb, dandelion, and turmeric each 30 g, and raw mountain gardenia, Coptis chinensis, Salvia miltiorrhiza, and red peony root 15 g each. All the above were decocted to 100–200 mL to perform enema, once every 12 hours. 12 hours after the operation till drinking and eating, the intestines have been cleared, and the damp-heat is gradually receding, manifesting as deficiency of both qi and blood, liver stagnation, and qi stagnation, but still can be mixed with the signs of damp-heat internal accumulation, qi stagnation, and blood stasis. The treatment should be based on soothing the liver and gallbladder, regulating qi and promoting blood circulation, strengthening the root, and supporting the vitality. The drug includes Bupleurum, costus root, and licorice each 12 g, rhubarb, Scutellaria baicalensis, Pinellia chinensis, Citrus aurantium, and Evodia each 9 g, Gardenia jasminoides, Coptis chinensis, and Magnolia 9 g each, and Astragalus and Codonopsis 15 g each. All the above were first decocted with 500 mL of water for 30 min, and then, 150 mL of juice was extracted. Then, it was redecocted with 400 mL of water for 20 min, and then, 150 mL of juice was extracted. The two decoctions were mixed, one dose/d, taken in two servings.


## 2.3. Outcome Measure

Outcome measures included intraoperative indices, postoperative indices, postoperative complications, and changes in postoperative blood indices. Intraoperative indices included operative time, intraoperative bleeding volume, and operative incision length. Postoperative indices included postoperative exhaust time, number of patients in ICU care, the average length of hospital stay, average hospitalization cost, and primary suture of the common bile duct. Postoperative complications included wound infection, secondary pneumonia, abdominal abscess, biliary fistula, abdominal bleeding, and subdiaphragmatic pus accumulation. Postoperative blood indices included white blood cell changes, total bilirubin changes, and albumin changes at 24 h postoperatively.


## 2.4. Statistical Analysis

SPSS 18.0 was used for data analyses. The measurement data were expressed as (x¯ ± s) and processed using the t-test. The count data were expressed as the number of cases (rate) and processed using the chi-square test. Differences were considered statistically significant at P<0.05.


## 3. Results

### 3.1. Intraoperative Indices

Laparoscopic fiberoptic choledochoscopy was associated with less intraoperative bleeding and a shorter surgical incision length versus open surgery (P<0.05). All eligible patients showed similar operative time (P>0.05) (Table 1).Table 1
Comparison of intraoperative indices.
GroupnOperative time (min)Intraoperative bleeding (ml)Surgical incision length (cm)Experimental group63203.21 ± 52.3468.25 ± 24.103.51 ± 0.25Conventional group47204.69 ± 54.1199.14 ± 28.1515.35 ± 2.47t0.1446.04932.738P value0.443≤0.001≤0.001


### 3.2. Postoperative Indices

Laparoscopic fiberoptic choledochoscopy resulted in shorter postoperative exhaust time and mean length of stay and a higher mean hospitalization cost versus open surgery (P<0.05). There was no significant difference in the number of patients with ICU monitoring or primary suture of the common bile duct between the two groups (P>0.05) (Table 2).Table 2
Comparison of postoperative indices.
GroupnPostoperative exhaust time (d)Number of patients with ICU monitoring (n (%))Mean length of stay (d)Mean hospitalization cost (Yuan)Primary suture of the common bile duct (n (%))Experimental group633.25 ± 0.926 (9.52)13.04 ± 3.4422245.36 ± 7245.114 (6.35)Conventional group474.51 ± 1.753 (6.38)23.59 ± 11.4018236.98 ± 6510.472 (4.26)t/χ24.4940.05911.9593.0430.003P value≤0.0010.808≤0.0010.0020.957


### 3.3. Postoperative Complications

The eligible patients after laparoscopic fiberoptic choledochoscopy experienced fewer complications versus those after open surgery (P<0.05) (Table 3).Table 3
Postoperative complications (n (%)).
GroupnWound infectionSecondary pneumoniaAbdominal abscessBiliary fistulaAbdominal hemorrhageSubdiaphragmatic pus accumulationExperimental group63001 (1.59)1 (1.59)1 (1.59)3 (4.76)Conventional group472 (4.26)1 (2.13)2 (4.26)3 (6.38)1 (2.13)9 (19.15)χ25.732P value0.017


### 3.4. Postoperative Blood Indices

Laparoscopic fiberoptic choledochoscopy had a milder impact on postoperative albumin decrease versus open surgery (P<0.05). No significant difference was found in the postoperative leukocyte changes and total bilirubin decrease between the two groups (P>0.05) (Table 4).Table 4
Comparison of postoperative blood indices.
GroupsnChange in white blood cells (∗109/L)Decrease in total bilirubin (μmol/L)Decrease in albumin (μ/L)Experimental group633.64 ± 1.6528.65 ± 12.475.42 ± 2.11Conventional group473.73 ± 1.6024.98 ± 10.638.06 ± 3.42t0.2881.6634.670P value0.3870.050≤0.001


## 3.1. Intraoperative Indices

Laparoscopic fiberoptic choledochoscopy was associated with less intraoperative bleeding and a shorter surgical incision length versus open surgery (P<0.05). All eligible patients showed similar operative time (P>0.05) (Table 1).Table 1
Comparison of intraoperative indices.
GroupnOperative time (min)Intraoperative bleeding (ml)Surgical incision length (cm)Experimental group63203.21 ± 52.3468.25 ± 24.103.51 ± 0.25Conventional group47204.69 ± 54.1199.14 ± 28.1515.35 ± 2.47t0.1446.04932.738P value0.443≤0.001≤0.001


## 3.2. Postoperative Indices

Laparoscopic fiberoptic choledochoscopy resulted in shorter postoperative exhaust time and mean length of stay and a higher mean hospitalization cost versus open surgery (P<0.05). There was no significant difference in the number of patients with ICU monitoring or primary suture of the common bile duct between the two groups (P>0.05) (Table 2).Table 2
Comparison of postoperative indices.
GroupnPostoperative exhaust time (d)Number of patients with ICU monitoring (n (%))Mean length of stay (d)Mean hospitalization cost (Yuan)Primary suture of the common bile duct (n (%))Experimental group633.25 ± 0.926 (9.52)13.04 ± 3.4422245.36 ± 7245.114 (6.35)Conventional group474.51 ± 1.753 (6.38)23.59 ± 11.4018236.98 ± 6510.472 (4.26)t/χ24.4940.05911.9593.0430.003P value≤0.0010.808≤0.0010.0020.957


## 3.3. Postoperative Complications

The eligible patients after laparoscopic fiberoptic choledochoscopy experienced fewer complications versus those after open surgery (P<0.05) (Table 3).Table 3
Postoperative complications (n (%)).
GroupnWound infectionSecondary pneumoniaAbdominal abscessBiliary fistulaAbdominal hemorrhageSubdiaphragmatic pus accumulationExperimental group63001 (1.59)1 (1.59)1 (1.59)3 (4.76)Conventional group472 (4.26)1 (2.13)2 (4.26)3 (6.38)1 (2.13)9 (19.15)χ25.732P value0.017


## 3.4. Postoperative Blood Indices

Laparoscopic fiberoptic choledochoscopy had a milder impact on postoperative albumin decrease versus open surgery (P<0.05). No significant difference was found in the postoperative leukocyte changes and total bilirubin decrease between the two groups (P>0.05) (Table 4).Table 4
Comparison of postoperative blood indices.
GroupsnChange in white blood cells (∗109/L)Decrease in total bilirubin (μmol/L)Decrease in albumin (μ/L)Experimental group633.64 ± 1.6528.65 ± 12.475.42 ± 2.11Conventional group473.73 ± 1.6024.98 ± 10.638.06 ± 3.42t0.2881.6634.670P value0.3870.050≤0.001


## 4. Discussion

The current conventional surgical methods used for the treatment of gallbladder stones complicated with common bile duct stones yield a high stone removal rate and are insusceptible to previous upper abdominal surgery and bile duct surgery [7]. However, clinical experience in recent years has revealed certain downsides to open surgery.Laparoscopic fiberoptic choledochoscopy has gained wide application in hepatobiliary surgery, with short operative time, small scar, rapid postoperative recovery, no adhesion formation, and low postoperative complication rate [8, 9]. In addition, the total success rate of the laparoscopic common bile duct can reach over 90% [10, 11]. Laparoscopic fiberoptic choledochoscopy has been reported to feature a higher stone removal rate and better biliary decompression after indwelling T-tube versus open surgery, resulting in a lower risk of complications and a better prognosis [12]. The present results showed that laparoscopic fiberoptic choledochoscopy showed less intraoperative bleeding, shorter surgical incision length, shorter postoperative exhaust time, shorter average hospital stay, higher average hospitalization cost, lower postoperative complication rate, and lower postoperative albumin decline versus open surgery, suggesting that laparoscopic fiberoptic choledochoscopy results in better perioperative indices but also higher costs versus, which is consistent with previous research results [13]. It has also been shown that laparoscopic fiberoptic choledochoscopy significantly reduces the activation of serum inflammatory factors and maintains the stability of serum factors and polymorphonuclear leukocyte function, and minimally invasive surgery has less suppression of delayed T cell metaplasia and better protects the integrity of the body’s defense function. In recent years, it has been found that the important role of albumin in the perioperative period has been widely appreciated and is considered an influencing factor in the development of postoperative complications [14, 15]. Therefore, laparoscopic fiberoptic choledochoscopy is a safe and effective treatment for gallbladder stones and common bile duct stones under strict control of the surgical indications.The analysis shows that laparoscopic fiberoptic choledochoscopy features the following advantages versus open surgery. Laparoscopy expands the surgical field of view and ensures effective observation of the lesion from multiple angles, allowing fine local manipulation while achieving overall grasp and disease control. Patients without typical symptoms are given effective exploration, which shortens the length of the incision, has the dual role of exploration and treatment, and prevents unnecessary trauma [14]. Due to the small surgical incision, the abdominal cavity is not directly accessible to the outside world, which avoids the adverse stimulation of foreign bodies caused by external objects and minimizes the disturbance caused to the gastrointestinal tract. The small abdominal incision is less susceptible to postoperative scarring and shortens the postoperative healing [15].Traditional Chinese medicine plays an important role in regulating the internal environment of the human body, regulating the body’s immunity, removing toxins and oxygen free radicals in the body, and improving the systemic inflammatory response during endotoxemia. In the early postoperative period, rhubarb,Citrus aurantium, peach kernel, and red peony root were used as the main components of compound Dachengqi decoction, while dandelion, rhubarb, Coptis, and Salvia also have the effect of activating serum heat and detoxification, and Artemisia capillaris Thunb, Lysimachia christinae Hance, and Gardenia jasminoides can relieve jaundice. The combination of the three can play the role of clearing away heat and dampness and promoting gallbladder and jaundice. According to modern medical research, it can promote the secretion of bile by hepatocytes and increase the content of bile acid-conjugated bilirubin in bile, which is beneficial for gallbladder expulsion; in addition, it can promote intestinal peristalsis and defecation, reduce the translocation of intestinal bacteria, protect the intestinal barrier, and improve intestinal and lung function. The pathogenesis of this disease is liver stagnation, qi stagnation, damp-heat accumulation in the liver and gallbladder, and disorder of dredging. The Bupleurum, costus root, rhubarb, Scutellaria, Pinellia, and other medicines can promote bile secretion, improve bile composition, scour the bile duct system, and promote the shedding, melting, and discharge of bile mud and bile sand attached to the wall, thereby further relieving cholestasis, regulating sphincter function and biliary pressure, controlling inflammation, relieving symptoms, and promoting the dissipation of toxins and the removal of inflammatory factors.


## 5. Conclusion

Laparoscopic fiberoptic choledochoscopy has better perioperative indices, lower incidence of postoperative complications, smaller postoperative albumin changes, and superior overall performance versus conventional open surgery for gallbladder stones complicated with common bile duct stones. The limitation of this study is that long-term follow-up of postoperative patients was not performed to assess the long-term quality of life and psychological status of patients, and the number of study cases will be expanded to increase long-term follow-up in the future.



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*Source: 5668482-2022-04-28.xml*