# Anterior-Posterior Instability of the Knee Following ACL Reconstruction with Bone-Patellar Tendon-Bone Ligament in Comparison with Four-Strand Hamstrings Autograft

Authors: A. G. Angoules; K. Balakatounis; E. C. Boutsikari; D. Mastrokalos; P. J. Papagelopoulos
Journal: Rehabilitation Research and Practice
 (2013)

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## Abstract

Purpose. To evaluate  anterior-posterior knee laxity using two different autografts. Material-Methods. 40 patients, (34 males and 6 women), 17–54 years old (mean: 31), were  included in the present study. Group A (4SHS = 20) underwent reconstruction using  four-strand  hamstrings, and group B (BPBT = 20) underwent reconstruction using bone-patellar tendon-bone  autograft. Using the KT-1000 arthrometer,  knee instability was  calculated in  both knees of all  patients preoperatively and  3, 6, and 12 months after surgery at the ACL-operated knee. The contralateral healthy knee was used as an internal control group. Results. Anterior-posterior instability using the KT1000 Arthrometer was found to be increased after  ACL insufficiency. The recorded laxity improved after arthroscopic  ACL reconstruction in both groups. However, statistically significant greater values were detected in the bone-patellar tendon-bone group, which  revealed reduction of anteroposterior stability values to an extent, where no statistical significance with the normal  values even after 3 months after surgery was observed. Conclusions. Anterior-Posterior instability of the knee improved significantly after  arthroscopic  ACL reconstruction. The bone-patellar tendon-bone graft provided an obvious greater stability.


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## Body

## 1. Introduction

The anterior cruciate ligament (ACL) is  a major  stabilizing element of the knee since it is the main anatomical structure which prevents the anterior displacement of the tibia relative to the femur [1, 2].Simultaneously, it is an important factor for the normal knee movements, since it contributes not only  to  the static, but also to the  dynamic stability of the joint [3].Dynamic stability is guaranteed by the presence of specific ligament mechanoreceptors which are considered an essential element for knee proprioception as it has been revealed by a few anatomical and histological studies [3–6].The ACL is the most frequently injured knee ligament especially as regards sports that include movements with sudden direction changes, as knee supports body weight during them [7–9]. These lesions often lead to ligament rupture with subsequent impairment and instability of the knee.Diagnosis is based presumably on several clinical examinations such as  Lachman test, the anterior drawer test, and pivot shift test [2]. This kind of examinations, depending on the extent of the time that is inserted between the examination and the accident, the adeptness, and the experience of the health professional, as well as the body type of the patient, can lead to different results [10].Thus, numerous objectively measurable methods of evaluation have been developed, by using mechanical devices such as KT-1000 which is the most frequently used [10–13].A significant number of patients with ACL rupture undergo surgical reconstruction  that it is carried out with different types of autografts, with bone-patellar tendon-bone ligament and  four-strand hamstrings grafts, being the most widely performed, with single and double  bundle  techniques [14–17].In this paper, the anterior-posterior instability of the knee after ACL rupture and deficiency, as well as joint’s restoration  stability after ACL reconstruction  with the aforementioned autografts, was studied, using the KT-1000 arthrometer.


## 2. Materials and Methods

Forty nonprofessionals athletes, with clinically and MRI recognizable unilateral ACL rupture and knee insufficiency, underwent ACL reconstruction with two different types of autografts. There were 34 men and 6 women, with a mean age of 31 years (range 17–54 years). Exclusion criteria were ages smaller than 16 years, postoperative complications, presence of injuries or surgery, pain or function wastage in the corresponding knee within the last 6 months, inability of cooperation, and psychiatric diseases, as well as alcoholism or usage of addictive substances.The subjects were randomized into 2 groups according to their gender and age. Group A included 20 patients (16 men and 4 women) with ACL rupture that underwent reconstruction using four-strand autografts (4SHS). Group B was consisted of 20 patients (18 men and 2 women) that underwent reconstruction with bone-patellar-tendon-bone (BPTB) ligament.All patients that participated in the undersigned study were operated arthroscopically with the same technique, while they followed the exact same physical rehabilitation program. The objective measurable anteroposterior knee instability was calculated using a KT-1000 arthrometer (MEDmetric, Corporation, San Diego, CA, USA) [18] (Figure 1) preoperatively and postoperatively,  in the 3rd, the 6th, and 12th months after ACL reconstruction.Figure 1The knees of the patient were placed in 30 degrees of flexion, with the heel symmetrically placed on a foot rest, so that the tibiae could both stand in 15 degrees of external rotation. In the knee, there were exerted sequentially forces equal to 67 N, 89 N with anterior direction, and the tibial displacement was counted in millimeters between 89 N and 67 N [19, 20].The study has been approved by the Institutional Review Board/Ethics Committee of the authors' institutions.


## 3. Statistical Analysis

The evaluation variables were described using the number of participants(N), the mean values or medians, if it was estimated that there was not a normal distribution of values and standard deviations.In order to control the interaction between the surgical technique factor and the time factor, the mixed model of variance analysis with 2 factors was used (two way ANOVA mixed model).For the longitudinal comparison of variables per group (baseline versus values of 3rd month versus values of 6th month versus values of 12th month), the model of variance analysis with one factor repeated measures was used (one factor repeated measures ANOVA).For the analysis of the differences between group A and  group B over time, the percentage of changes in comparison with the baseline group was estimated, for the period of 3, 6, and 12 months.The comparison of percentage changes from baseline between the two groups was performed with thet-test for independent samples (independent samples t-test). The comparison of percentage changes from baseline variables between the healthy and the injured knee was performed using the t-test for paired samples (paired sample t-test).All tests were two sided with significance level,P=0.05. Statistical analyses were done using the SPSS vr 13.00 (Statistical Package for the Social Sciences, SPSS Inc., Chicago, IL, USA).


## 4. Results

In group A, as well as in group B, a statistically considerable variation amongst the normal and the injured knee was recorded preoperatively (Table1).Table 1
KT1000
N
Mean value
Standard deviation
P value
Group A
ACL-deficient
20
6.7000
1.94936
<0.0005
Healthy
20
2.0000
1.21395
Group B
ACL-deficient
20
6.2500
1.77334
<0.0005
Healthy
20
1.6500
.98809Secondarily, it followed the control of the KT-1000 variable overtime separately for every type, using the one factor repeated measures ANOVA.Statistically significant variation was recorded amongst the absolute changes of variable KT-1000 in Group A(P<0.0005). Based on the performed pairwise comparisons, variation from the preoperative values it was recorded (Table 2).Table 2
Time of evaluation (months)
Group A
N
Mean
SD
Pairwise comparisons
Baseline
3 months
6 months
12 months
Baseline
20
6.7000
1.94
—
P < 0.0005
P < 0.0005
P < 0.0005
3
20
3.1000
1.29
—
—
N.S
N.S
6
20
3.0000
1.29
—
—
—
N.S
12
20
2.8000
1.28
—
—
—
—
Overall Sig.
P < 0.0005
SD: standard deviation; overall sig: overall significance.Statistically conspicuous change was also recorded amongst the absolute changes of variable KT-1000 in Group B (Table3).Table 3
Time of evaluation (months)
Group  B
N
Mean
SD
Pairwise comparisons
Baseline
3 months
6 months
12 months
Baseline
20
6.2500
1.77
—
P < 0.0005
P < 0.0005
P < 0.0005
3
20
1.9500
1.39
—
—
N.S
N.S
6
20
1.7500
1.48
—
—
—
N.S
12
20
1.7500
1.48
—
—
—
—
Overall sig.
P < 0.0005
SD: standard deviation; overall sig: overall significance.The pairwise comparisons showed differentiation between all measurements and the preoperative values. The percentage change of KT-1000 from baseline to 12 months was also assayed, using the parametrict-test for independent samples, and the nonparametric Mann-Whitney test, while the results were expressed as median when normal distribution was violated.A statistically significant alteration amongst the two types of percentage changes from baseline  to 3, 6, and 12 months, respectively, for the variable KT-1000 was calculated (Tables4 and 5).Table 4
Median % change from baseline
N
Mean
Mean standard error
P value
3 months
Graft A
20
−53.9518
4.42350
0.025
Graft B
20
−68.9266
4.65002
6 months
Graft A
20
−55.2217
4.54732
0.009
Graft B
20
−73.2599
4.78314
12 months
Graft A
20
−58.3050
4.54709
0.029
Graft B
20
−73.2599
4.78314Table 5
Median % change from baseline
N
Median
P value
3 months
Graft A
20
−52.78
0.033
Graft B
20
−66.67
6 months
Graft A
20
−53.57
0.013
Graft B
20
−77.50
12 months
Graft A
20
−58.57
0.052
Graft B
20
−77.50


## 5. Discussion

In this paper, the anterior laxity of the knee after rupture and insufficiency of the ACL was studied, as well as the variation of this parameter after ligament reconstruction with BPBT in comparison  with 4SHS graft.The evaluation of knee instability was performed with KT 1000 arthrometer.This medical device is a useful instrument that performs objectively the relative movement of the tibia over the femur after ACL reconstruction [11, 12, 19].The reliability of this method is recorded between  0,83 and 0,88, whilst the sensitivity  is calculated up to 90%. Thus, it is proposed that it is capable of replacing the Lachman-Noulis test [13].The anterior-posterior instability of the knee after rupture  and insufficiency of the ACL, as measured by the KT-1000, reveals increased values in this study which is in line with the international literature [12, 19, 21].This instability shows improvement after reconstruction of the deficient ligament. Both grafts are used to improve the laxity of the knee, with the BPBT being the most appropriate graft for the desirable result.In fact, the group that underwent the operation with the specific type of graft displays a decrease of the counted instability in a degree that there are no differences of statistical importance as regards the preoperative values of the injured knee during the 6th postoperative month. In previous studies, it is also recorded a higher percentage of patients  with a difference less than 3 mm in anteroposterior laxity amongst both knees and a generally better stability in the BPBT group in comparison with the 4SHS group [22–31]. Fewer studies could not detect differences in the knee stability  amongst the two grafts with this method [24, 31–35] marginally improved or they recorded anteroposterior instability, but not in a statistically important level in the hamstrings group [36, 37]. Holm et al. in a recent research after a long-term observation, and after ligament reconstruction, report similar results in the restoration of the anteroposterior instability with both grafts [38].Both autografts have sufficient tensile strength and provide adequate stability to the knee [16, 39, 40].As the patellar tendon graft has been associated with donor-site morbidity such as anterior knee pain, loss of sensation, patellar fracture, inferior patellar contracture, and loss of extension torque, hamstrings use as an alternative graft option has gained an increased popularity in the last years [34, 41]. The latter is thought to be followed by fewer complications [17, 42, 43].Different surgical procedures such as the transtibial and the arthroscopic anteromedial portal technique have been used for the drilling of the femoral tunnel in ACL reconstruction using 4SHS with comparable results on the most evaluated parameters [44].  As regards the fixation techniques, it is accepted that cross-pin femoral devices provide a high fixation strength and sufficient resistance against slippage in comparison with the conventional interference screws [45].Different parameters are considered to influence the final functional result following ACL reconstruction, apart from the anteroposterior stability established [46]. ACL is both a static and a dynamic element of vital importance for the functionality of the knee [3, 47]. These particularly complex sensorimotor mechanisms exist within a secure and steady environment which is the result of the static mechanical improvement provided by the graft itself [5].Obviously, apart from the graft choice, the postoperative rehabilitation is capable of improving the end result of the operation, since it contributes to the restoration of proprioceptive deficits after rupture and impairment of the ACL [47]. Predominantly, patients with significant proprioceptive insufficiency may be helped by participating in physical therapy programs that focus on proprioception of the lower limb and by returning to functional activities, in addition to standard rehabilitation programs that focus mainly on the restoration of muscle strength [48, 49].


## 6. Conclusion

After ACL rupture and deficiency, increased values of anterior-posterior knee instability are recorded and accurately measured with KT-1000 arthrometer.This instability can be restored after 6 months following ACL reconstruction with bone-patellar-bone-tendon or four-strand hamstrings autografts. Although both grafts are capable of restoring the anterior laxity of the joint, the BPBT graft appears to excel, as it ensures greater stability.Additional clinical trials are required to indicate the ideal selection of the graft for every individual that suffered from ACL rupture and insufficiency, apart from the static and the notably dynamic role of the ligament.In particularly for patients undergoing ACL reconstruction using 4SHS, programmes for neuromuscular control and proprioception enhancement should be necessarily planned.



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*Source: 572083-2013-07-10.xml*