# An Efficient and Green Method for Synthesis of 2,4,5-Triarylimidazoles without Use of Any Solvent, Catalyst, or Solid Surface

Authors: Swati Samanta; Saheli Sarkar; Rammohan Pal; Asok K. Mallik
Journal: Organic Chemistry International
 (2013)

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## Abstract

An efficient and green method for synthesis of 2,4,5-triarylimidazoles without use of any catalyst or solvent has been developed simply by heating (at 130°C) of mixtures of 1,2-diketone, aromatic aldehyde, and ammonium acetate in 1 : 1 : 3 mole ratio.


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## Body

## 1. Introduction

Multicomponent reactions (MCRs) have emerged as a powerful tool for convergent synthesis of many complex organic molecules [1–6]. They are one-pot processes bringing together three or more components in a particular sequence of reactions and show high atom economy and remarkable selectivity. Because of their operational simplicity, MCRs have occupied a very prominent place in diversity oriented synthesis which is an important requirement for drug discovery. The imidazole nucleus is a rich source for getting biologically important organic molecules. Compounds containing imidazole moiety show a range of pharmacological properties and play important roles in biochemical processes. Various substituted imidazoles act as inhibitors of P38 MAP kinase [7] and B-Raf kinase [8], glucagon receptors [9], pesticides [10], fungicides [10], herbicides [11], and antitumor [12], anti-inflammatory [13], and antithrombotic [14] agents. Moreover, they are used in photography as photosensitive compounds [15]. 2,4,5-Triarylimidazoles (3) form an important group of substituted imidazoles having many of the above biological activities and material properties. Retrosynthetic analysis of 3 suggests the readily available compounds aromatic 1,2-diketones, aromatic aldehydes, and ammonia as their precursors. This has led to the development of a large number of synthetic methods for 3using these simple starting materials. Almost all of these methods use ammonium acetate as the ammonia source. Many of the reported methods require long reaction time and  use of expensive catalysts and organic solvents [16–23]. The current literature shows that there has been a growing trend towards green synthesis of these compounds [24, 25]. However, in such reported green methods, also use of catalysts or organic solvents could not be avoided. The current trend towards development of catalyst-free and solvent-free reaction conditions for organic synthesis [26, 27] encouraged us to study the same reaction under thermal condition without using any solvent or catalyst. The remarkable success in this endeavor is presented herein.


## 2. Results and Discussion

Our present method involves subjecting of an intimate mixture of 1,2-diketone, aromatic aldehyde, and ammonium acetate in 1 : 1 : 3 mole ratio directly to heat (130°C, 3–6 h). A range of structurally diverse aldehydes belonging to the categories aromatic and heterocyclic aldehydes were taken (Scheme1). To our delight, the target compounds were obtained in good to very good yield in this method for all the combinations. The yields of the products are presented in Table 1.Table 1
Synthesis of 2,4,5-triarylimidazoles (3) under catalyst-free and solvent-free conditions.
Entry
Starting materials
Product
Time (h)
Yield (%)
M. P. (Lit.)reference
1 with Ar1 =
2 with Ar2 =
1
C6H5
C6H5
3a
3
80
272-273 (272–274) [19]
2
C6H5
4-CH3-C6H4
3b
3
75
227-228 (227-228) [19]
3
C6H5
4-Cl-C6H4
3c
3
78
261-262 (261-262) [19]
4
C6H5
4-Br-C6H4
3d
3
81
245-246 (244–246) [19]
5
C6H5
4-CH3O-C6H4
3e
3
76
226-227 (227-228) [19]
6
C6H5
3,4-(OCH2O)C6H3
3f
3
73
248–250 (248–250) [19]
7
C6H5
3-O2N-C6H4
3g
3
90
>300 (>290) [19]
8
C6H5
4-(CH3)2N-C6H4-
3h
3
45
256–258 (257-258) [19]
9
C6H5
3-CH3O,4-HO-C6H3-
3i
5
67
165–167 (166) [28]
10
C6H5
2-Thienyl
3j
4
67
261–263 (260–262) [29]
11
C6H5
3-Pyridyl
3k
3
66
245–247 (244–246) [30]
12
4-CH3-C6H4-
C6H5
3l
5
59
252-253 (254) [31]
13
4-CH3-C6H4-
4-Cl-C6H4
3m
5
64
262-263 (263-264) [32]
14
4-CH3-C6H4-
4-CH3O-C6H4
3n
6
61
250-251 (250-251) [33]Scheme 1
Synthesis of 2,4,5-triarylimidazoles (3) under catalyst-free and solvent-free condition. Ar1 = C6H5; 4-CH3–C6H4; Ar2 = C6H5; 4-CH3–C6H4; 4-Cl–C6H4; 4-Br–C6H4; 4-CH3O–C6H4; 3,4-(OCH2O) C6H3; 3-O2N–C6H4; 4-(CH3)2N–C6H4; 3-CH3O, 4-HO–C6H3; 2-Thienyl; 3-Pyridyl.In the method being reported, it was a common observation that the reactions were very clean and no side product was formed in any run. In fact, the crude products obtained were of high purity and did not require any chromatographic separation. Their crystallization from ethanol provided analytically pure samples. More significantly, the whole operation did not require any solvent, organic or inorganic, at any stage. Furthermore, the reaction condition has been found to be mild enough to tolerate a variety of functionalities such as NO2, Cl, OH, and OMe.


## 3. Conclusion

We report here a very simple and efficient green method for synthesis of 2,4,5-triarylimidazoles avoiding the use of any solvent, catalyst, and solid surface.


## 4. Experimental

### 4.1. General

Melting points were recorded on a Köfler block. IR spectra were recorded on a Perkin Elmer FT-IR spectrophotometer (Spectrum BX II) in KBr pellets.1H NMR spectra and 13C NMR spectra were recorded in CDCl3 on a Bruker AV-300 (300 MHz) spectrometer. Analytical samples were routinely dried in vacuo at room temperature. Microanalytical data were recorded on two Perkin-Elmer 2400 Series II C, H, N analyzers. Mass spectra were measured in the following ways FAB-MS [Jeol the M Station JMS.700]. TLC was performed with silica gel G made by  SRL Pvt. Ltd. Petroleum ether had the boiling range 60–80°C.


### 4.2. General Method for Synthesis of 2,4,5-Triarylimidazoles(3)

In a typical experiment, an intimate mixture of benzil (1 mmol), aromatic aldehyde (1 mmol), and ammonium acetate (3 mmol) was taken in a round-bottom flask (50 mL) fitted with a CaCl2-guard tube and the flask was heated in an oil bath at 130°C. Initially, the reaction mixture melted and after some time (ca. 1–3 h) it began to solidify. When the reaction mixture solidified totally (time period mentioned in Table 1), it was cooled to room temperature and to it water (20 mL) was added. The resulting solid mass was crushed and it was filtered, and the residue was washed with water and then dried. The crude product so obtained was crystallized from ethanol.All of the products3a-n were known compounds and were identified by comparison of their physical and spectral data with those reported in the literature. The spectral data recorded by us are given below.


#### 4.2.1. Compound3a

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): and 7.95 (br. d, 2H, J= 8.1 Hz), 7.59 (br. d, 4H, J = 7.8 Hz), 7.28–7.48 (m, 9H); Anal. Calcd. for C21H16N2 (296.37): C, 85.11; H, 5.44; N, 9.45. Found: C, 85.26; H, 5.72; N, 9.31.


#### 4.2.2. Compound3b

Colorless needles, IR (KBr, cm−1): 3414, 3027, 2363, 1654, 1601, 1493, 1449, 1381; 1H NMR (300 MHz, CDCl3, δ/ppm): 7.86 (d, 2H, J = 8.1 Hz), 7.50 (br. d, 4H, J  ≈ 7.8 Hz), 7.21–7.31 (m, 8H), 2.38 (s, 3H, CH3); 13C NMR (75 MHz, CDCl3, δ/ppm): 146.2, 138.9, 132.9, 129.6, 128.6, 127.8, 127.4, 127.1, 125.2, 21.3; FAB MS (M + H)+: Calcd. 311.3. Found 311.3; Anal. Calcd. for C22H18N2 (310.39): C, 85.13; H, 5.85; N, 9.03. Found: C, 84.86; H, 5.75; N, 8.82.


#### 4.2.3. Compound3c

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J= 8.7 Hz), 7.53 (br. d, 4H, J  ≈ 7.0 Hz), 7.28−7.40 (m, 8H).


#### 4.2.4. Compound3d

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.78 (d, 2H, J = 8.5 Hz), 7.54–7.58 (m, 6H), 7.28–7.38 (m, 6H).


#### 4.2.5. Compound3e

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.88 (br. d, 2H, J = 8.4 Hz), 7.49 (br. d, 4H, J  ≈ 6.6 Hz), 7.24–7.30 (m, 6H), 6.93 (d, 2H, J = 9 Hz), 3.82 (s, 3H).


#### 4.2.6. Compound3f

Colorless needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 12.49 (s, 1H, NH), 7.21–7.63 (m, 12H), 7.03 (d, 1H, J = 8.4), 6.08 (s, 2H, –OCH2O–); 1H NMR (300 MHz, CDCl3, δ/ppm): 7.52 (br. d, 4H, J  ≈ 7.2 Hz), 7.39 (d, 1H, J = 8.2 Hz), 7.46 (br. s, 1H), 7.26–7.33 (m, 5H), 6.83 (d, 1H, J = 8.0 Hz), 6.00 (s, 2H, –OCH2O–).


#### 4.2.7. Compound3g

Yellow needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 13.08 (s, 1H), 8.94 (s, 1H), 8.50 (d, 1H, J = 7.8 Hz), 8.19 (d, 1H, J = 8.1 Hz), 7.76 (t, 1H, J = 7.8 Hz), 7.32–7.53 (m, 10H).


#### 4.2.8. Compound3h

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.82 (d, 2H, J = 7.7 Hz), 7.52–7.54 (m, 4H), 7.26–7.33 (m, 6H), 6.74 (d, 2H, J = 7.8 Hz), 2.99 (s, 6H, NMe2).


#### 4.2.9. Compound3i

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 12.40 (br. s, 1H, NH), 9.24 (br. s, 1H, OH), 7.19–7.54 (m, 11H), 7.61 (br. s, 1H), 6.84 (d, 1H, J = 8.2 Hz), 3.84 (s, 3H, OCH3).


#### 4.2.10. Compound3j

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.70 (br. d, 1H, J  ≈ 3 Hz), 7.43–7.46 (m, 4H), 7.31 (dd, 1H, J = 5.1 and 1.0 Hz), 7.24−7.28 (m, 6H), 7.04 (dd, 1H, J = 4.8 and 3.7 Hz).


#### 4.2.11. Compound3k

Colorless needles, IR (KBr, cm−1): 3376, 3052, 2200, 1663, 1604, 1563, 1469, 1438, 1382; 1H NMR (300 MHz, CDCl3, δ/ppm): 9.28 (br. s, 1H, H-2 of 3-pyridyl), 8.50 (d, 1H, J = 8.0 Hz, H-4 of 3-pyridyl), 8.43 (d, 1H, J = 4.6 Hz, H-6 of 3-pyridyl), 7.54–7.56 (m, 4H, o-proton of 2 × C6H5), 7.28–7.39 (m, 7H, m- and p-protons of 2 × C6H5 and H-5 of 3-pyridyl); 13C NMR (75 MHz, CDCl3, δ/ppm) 148.9, 145.9, 143.1, 133.5, 132.6, 128.6, 128.0, 127.6, 126.7, 123.9; FAB MS (M + H)+: Calcd. 298.3. Found 298.3, Anal. Calcd. for C20H15N3 (297.35): C, 80.78; H, 5.08; N, 14.13. Found: C, 80.56; H, 5.31; N, 13.92.


#### 4.2.12. Compound3l

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.90 (d, 2H, J = 7.8 Hz), 7.42–7.48 (m, 6H), 7.36 (t, 1H, J = 7.5), 7.16 (d, 4H, J = 7.8 Hz), 2.36 (s, 6H, 2 × –CH3).


#### 4.2.13. Compound3m

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (2H, d, J = 8.1 Hz), 7.43 (d, 4H, J = 7.8 Hz), 7.40 (2H, d, J = 8.1 Hz), 7.14 (d, 4H, J = 7.6 Hz), 2.36 (s, 6H, 2 × –CH3).


#### 4.2.14. Compound3n

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J = 8.4 Hz), 7.43 (br. d, 4H, J= 7.2 Hz), 7.13 (br. d, 4H, J = 7.6 Hz), 6.96 (d, 2H, J = 8.5 Hz), 3.85 (s, 3H, –OCH3), 2.36 (s, 6H, 2 × –CH3).


## 4.1. General

Melting points were recorded on a Köfler block. IR spectra were recorded on a Perkin Elmer FT-IR spectrophotometer (Spectrum BX II) in KBr pellets.1H NMR spectra and 13C NMR spectra were recorded in CDCl3 on a Bruker AV-300 (300 MHz) spectrometer. Analytical samples were routinely dried in vacuo at room temperature. Microanalytical data were recorded on two Perkin-Elmer 2400 Series II C, H, N analyzers. Mass spectra were measured in the following ways FAB-MS [Jeol the M Station JMS.700]. TLC was performed with silica gel G made by  SRL Pvt. Ltd. Petroleum ether had the boiling range 60–80°C.


## 4.2. General Method for Synthesis of 2,4,5-Triarylimidazoles(3)

In a typical experiment, an intimate mixture of benzil (1 mmol), aromatic aldehyde (1 mmol), and ammonium acetate (3 mmol) was taken in a round-bottom flask (50 mL) fitted with a CaCl2-guard tube and the flask was heated in an oil bath at 130°C. Initially, the reaction mixture melted and after some time (ca. 1–3 h) it began to solidify. When the reaction mixture solidified totally (time period mentioned in Table 1), it was cooled to room temperature and to it water (20 mL) was added. The resulting solid mass was crushed and it was filtered, and the residue was washed with water and then dried. The crude product so obtained was crystallized from ethanol.All of the products3a-n were known compounds and were identified by comparison of their physical and spectral data with those reported in the literature. The spectral data recorded by us are given below.


### 4.2.1. Compound3a

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): and 7.95 (br. d, 2H, J= 8.1 Hz), 7.59 (br. d, 4H, J = 7.8 Hz), 7.28–7.48 (m, 9H); Anal. Calcd. for C21H16N2 (296.37): C, 85.11; H, 5.44; N, 9.45. Found: C, 85.26; H, 5.72; N, 9.31.


### 4.2.2. Compound3b

Colorless needles, IR (KBr, cm−1): 3414, 3027, 2363, 1654, 1601, 1493, 1449, 1381; 1H NMR (300 MHz, CDCl3, δ/ppm): 7.86 (d, 2H, J = 8.1 Hz), 7.50 (br. d, 4H, J  ≈ 7.8 Hz), 7.21–7.31 (m, 8H), 2.38 (s, 3H, CH3); 13C NMR (75 MHz, CDCl3, δ/ppm): 146.2, 138.9, 132.9, 129.6, 128.6, 127.8, 127.4, 127.1, 125.2, 21.3; FAB MS (M + H)+: Calcd. 311.3. Found 311.3; Anal. Calcd. for C22H18N2 (310.39): C, 85.13; H, 5.85; N, 9.03. Found: C, 84.86; H, 5.75; N, 8.82.


### 4.2.3. Compound3c

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J= 8.7 Hz), 7.53 (br. d, 4H, J  ≈ 7.0 Hz), 7.28−7.40 (m, 8H).


### 4.2.4. Compound3d

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.78 (d, 2H, J = 8.5 Hz), 7.54–7.58 (m, 6H), 7.28–7.38 (m, 6H).


### 4.2.5. Compound3e

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.88 (br. d, 2H, J = 8.4 Hz), 7.49 (br. d, 4H, J  ≈ 6.6 Hz), 7.24–7.30 (m, 6H), 6.93 (d, 2H, J = 9 Hz), 3.82 (s, 3H).


### 4.2.6. Compound3f

Colorless needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 12.49 (s, 1H, NH), 7.21–7.63 (m, 12H), 7.03 (d, 1H, J = 8.4), 6.08 (s, 2H, –OCH2O–); 1H NMR (300 MHz, CDCl3, δ/ppm): 7.52 (br. d, 4H, J  ≈ 7.2 Hz), 7.39 (d, 1H, J = 8.2 Hz), 7.46 (br. s, 1H), 7.26–7.33 (m, 5H), 6.83 (d, 1H, J = 8.0 Hz), 6.00 (s, 2H, –OCH2O–).


### 4.2.7. Compound3g

Yellow needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 13.08 (s, 1H), 8.94 (s, 1H), 8.50 (d, 1H, J = 7.8 Hz), 8.19 (d, 1H, J = 8.1 Hz), 7.76 (t, 1H, J = 7.8 Hz), 7.32–7.53 (m, 10H).


### 4.2.8. Compound3h

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.82 (d, 2H, J = 7.7 Hz), 7.52–7.54 (m, 4H), 7.26–7.33 (m, 6H), 6.74 (d, 2H, J = 7.8 Hz), 2.99 (s, 6H, NMe2).


### 4.2.9. Compound3i

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 12.40 (br. s, 1H, NH), 9.24 (br. s, 1H, OH), 7.19–7.54 (m, 11H), 7.61 (br. s, 1H), 6.84 (d, 1H, J = 8.2 Hz), 3.84 (s, 3H, OCH3).


### 4.2.10. Compound3j

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.70 (br. d, 1H, J  ≈ 3 Hz), 7.43–7.46 (m, 4H), 7.31 (dd, 1H, J = 5.1 and 1.0 Hz), 7.24−7.28 (m, 6H), 7.04 (dd, 1H, J = 4.8 and 3.7 Hz).


### 4.2.11. Compound3k

Colorless needles, IR (KBr, cm−1): 3376, 3052, 2200, 1663, 1604, 1563, 1469, 1438, 1382; 1H NMR (300 MHz, CDCl3, δ/ppm): 9.28 (br. s, 1H, H-2 of 3-pyridyl), 8.50 (d, 1H, J = 8.0 Hz, H-4 of 3-pyridyl), 8.43 (d, 1H, J = 4.6 Hz, H-6 of 3-pyridyl), 7.54–7.56 (m, 4H, o-proton of 2 × C6H5), 7.28–7.39 (m, 7H, m- and p-protons of 2 × C6H5 and H-5 of 3-pyridyl); 13C NMR (75 MHz, CDCl3, δ/ppm) 148.9, 145.9, 143.1, 133.5, 132.6, 128.6, 128.0, 127.6, 126.7, 123.9; FAB MS (M + H)+: Calcd. 298.3. Found 298.3, Anal. Calcd. for C20H15N3 (297.35): C, 80.78; H, 5.08; N, 14.13. Found: C, 80.56; H, 5.31; N, 13.92.


### 4.2.12. Compound3l

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.90 (d, 2H, J = 7.8 Hz), 7.42–7.48 (m, 6H), 7.36 (t, 1H, J = 7.5), 7.16 (d, 4H, J = 7.8 Hz), 2.36 (s, 6H, 2 × –CH3).


### 4.2.13. Compound3m

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (2H, d, J = 8.1 Hz), 7.43 (d, 4H, J = 7.8 Hz), 7.40 (2H, d, J = 8.1 Hz), 7.14 (d, 4H, J = 7.6 Hz), 2.36 (s, 6H, 2 × –CH3).


### 4.2.14. Compound3n

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J = 8.4 Hz), 7.43 (br. d, 4H, J= 7.2 Hz), 7.13 (br. d, 4H, J = 7.6 Hz), 6.96 (d, 2H, J = 8.5 Hz), 3.85 (s, 3H, –OCH3), 2.36 (s, 6H, 2 × –CH3).


## 4.2.1. Compound3a

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): and 7.95 (br. d, 2H, J= 8.1 Hz), 7.59 (br. d, 4H, J = 7.8 Hz), 7.28–7.48 (m, 9H); Anal. Calcd. for C21H16N2 (296.37): C, 85.11; H, 5.44; N, 9.45. Found: C, 85.26; H, 5.72; N, 9.31.


## 4.2.2. Compound3b

Colorless needles, IR (KBr, cm−1): 3414, 3027, 2363, 1654, 1601, 1493, 1449, 1381; 1H NMR (300 MHz, CDCl3, δ/ppm): 7.86 (d, 2H, J = 8.1 Hz), 7.50 (br. d, 4H, J  ≈ 7.8 Hz), 7.21–7.31 (m, 8H), 2.38 (s, 3H, CH3); 13C NMR (75 MHz, CDCl3, δ/ppm): 146.2, 138.9, 132.9, 129.6, 128.6, 127.8, 127.4, 127.1, 125.2, 21.3; FAB MS (M + H)+: Calcd. 311.3. Found 311.3; Anal. Calcd. for C22H18N2 (310.39): C, 85.13; H, 5.85; N, 9.03. Found: C, 84.86; H, 5.75; N, 8.82.


## 4.2.3. Compound3c

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J= 8.7 Hz), 7.53 (br. d, 4H, J  ≈ 7.0 Hz), 7.28−7.40 (m, 8H).


## 4.2.4. Compound3d

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.78 (d, 2H, J = 8.5 Hz), 7.54–7.58 (m, 6H), 7.28–7.38 (m, 6H).


## 4.2.5. Compound3e

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.88 (br. d, 2H, J = 8.4 Hz), 7.49 (br. d, 4H, J  ≈ 6.6 Hz), 7.24–7.30 (m, 6H), 6.93 (d, 2H, J = 9 Hz), 3.82 (s, 3H).


## 4.2.6. Compound3f

Colorless needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 12.49 (s, 1H, NH), 7.21–7.63 (m, 12H), 7.03 (d, 1H, J = 8.4), 6.08 (s, 2H, –OCH2O–); 1H NMR (300 MHz, CDCl3, δ/ppm): 7.52 (br. d, 4H, J  ≈ 7.2 Hz), 7.39 (d, 1H, J = 8.2 Hz), 7.46 (br. s, 1H), 7.26–7.33 (m, 5H), 6.83 (d, 1H, J = 8.0 Hz), 6.00 (s, 2H, –OCH2O–).


## 4.2.7. Compound3g

Yellow needles,1H NMR (300 MHz, d6-DMSO, δ/ppm): 13.08 (s, 1H), 8.94 (s, 1H), 8.50 (d, 1H, J = 7.8 Hz), 8.19 (d, 1H, J = 8.1 Hz), 7.76 (t, 1H, J = 7.8 Hz), 7.32–7.53 (m, 10H).


## 4.2.8. Compound3h

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.82 (d, 2H, J = 7.7 Hz), 7.52–7.54 (m, 4H), 7.26–7.33 (m, 6H), 6.74 (d, 2H, J = 7.8 Hz), 2.99 (s, 6H, NMe2).


## 4.2.9. Compound3i

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 12.40 (br. s, 1H, NH), 9.24 (br. s, 1H, OH), 7.19–7.54 (m, 11H), 7.61 (br. s, 1H), 6.84 (d, 1H, J = 8.2 Hz), 3.84 (s, 3H, OCH3).


## 4.2.10. Compound3j

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.70 (br. d, 1H, J  ≈ 3 Hz), 7.43–7.46 (m, 4H), 7.31 (dd, 1H, J = 5.1 and 1.0 Hz), 7.24−7.28 (m, 6H), 7.04 (dd, 1H, J = 4.8 and 3.7 Hz).


## 4.2.11. Compound3k

Colorless needles, IR (KBr, cm−1): 3376, 3052, 2200, 1663, 1604, 1563, 1469, 1438, 1382; 1H NMR (300 MHz, CDCl3, δ/ppm): 9.28 (br. s, 1H, H-2 of 3-pyridyl), 8.50 (d, 1H, J = 8.0 Hz, H-4 of 3-pyridyl), 8.43 (d, 1H, J = 4.6 Hz, H-6 of 3-pyridyl), 7.54–7.56 (m, 4H, o-proton of 2 × C6H5), 7.28–7.39 (m, 7H, m- and p-protons of 2 × C6H5 and H-5 of 3-pyridyl); 13C NMR (75 MHz, CDCl3, δ/ppm) 148.9, 145.9, 143.1, 133.5, 132.6, 128.6, 128.0, 127.6, 126.7, 123.9; FAB MS (M + H)+: Calcd. 298.3. Found 298.3, Anal. Calcd. for C20H15N3 (297.35): C, 80.78; H, 5.08; N, 14.13. Found: C, 80.56; H, 5.31; N, 13.92.


## 4.2.12. Compound3l

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.90 (d, 2H, J = 7.8 Hz), 7.42–7.48 (m, 6H), 7.36 (t, 1H, J = 7.5), 7.16 (d, 4H, J = 7.8 Hz), 2.36 (s, 6H, 2 × –CH3).


## 4.2.13. Compound3m

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (2H, d, J = 8.1 Hz), 7.43 (d, 4H, J = 7.8 Hz), 7.40 (2H, d, J = 8.1 Hz), 7.14 (d, 4H, J = 7.6 Hz), 2.36 (s, 6H, 2 × –CH3).


## 4.2.14. Compound3n

Colorless needles,1H NMR (300 MHz, CDCl3, δ/ppm): 7.83 (d, 2H, J = 8.4 Hz), 7.43 (br. d, 4H, J= 7.2 Hz), 7.13 (br. d, 4H, J = 7.6 Hz), 6.96 (d, 2H, J = 8.5 Hz), 3.85 (s, 3H, –OCH3), 2.36 (s, 6H, 2 × –CH3).



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*Source: 512074-2013-12-10.xml*