# Synthesis ofβ-Amino Carbonyl Compounds via the Iodine-Alumina Catalyzed Three-Component Coupling Reaction under Microwave Irradiation

Authors: Mantu Rajbangshi; Md. Rumum Rohman; Icydora Kharkongor; Hormi Mecadon; Bekington Myrboh
Journal: Organic Chemistry International
 (2011)

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## Abstract

Iodine-alumina was employed as a catalyst in the coupling reactions of aldehydes, enolizable ketones, or 1,3-dicarbonyls with methyl carbamate or aromatic amines under microwave irradiation to affordβ-amino carbonyl compounds in good-to-excellent yields. The key features of this environmentally friendly methodology are its operational simplicity, mild reaction conditions, and less reaction time.


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## Body

## 1. Introduction

In recent years, the use of multicomponent reactions has gained considerable attention in organic synthesis. In particular, the Mannich reaction has been widely used for the synthesis ofβ-amino carbonyl compounds. Owing to their importance as valuable building blocks for the preparation of 1,3-amino alcohols [1, 2], β-amino acids [3], as well as for the synthesis of various bioactive molecules such as the antibiotic nikkomycins and neopolyoxines [4, 5], several methods have been reported in the literature for the synthesis of β-amino carbonyl compounds using catalysts such as HClO4-SiO2 [6], silica supported sulfuric acid [7], bromodimethylsulfonium bromide (BDMS) [8], TMSCl [9], p-TSA [10], Sml3[11], Amberlyst-15 [12], and AuCl3-PPh3[13]. These methods however, have certain drawbacks such as moisture sensitivity of the catalyst [9, 10], longer reaction time [6–8], and the use of expensive metal salt as catalyst [11–13]. There is still scope, therefore, for an improved method for the synthesis of β-amino carbonyl compounds which can avoid the use of expensive and sensitive catalysts.Furthermore, the use of inorganic solid supported reagents provides an attractive procedure due to their characteristic properties such as enhanced reactivity and selectivity, simple workup procedure, and milder reaction conditions [14–17]. Among these inorganic supported reagents, iodine supported on dehydrated neutral alumina has found wide application because of its property to form activated iodonium ion [16]. Therefore, we decided to use activated iodonium ion produced from iodine adsorbed on neutral alumina for the coupling reactions of aldehydes, enolizable ketones or 1,3-dicarbonyls with methyl carbamate or aromatic amines using microwave as an energy source, which is superior to conventional methods [18–20] in terms of shorter reaction time and minimization of reaction byproducts. Recently, a method using molecular iodine as the catalyst has been reported for the synthesis of β-amino carbonyl compounds viaa three-component reaction involving aldehydes, ketones, and benzyl carbamates with good yields. However, this method has the disadvantage of longer reaction time [21].As a part of our ongoing research in the use of solid support reagents [22], we wanted to expand the scope of iodine-alumina (I2-Al2O3) as the catalyst for the synthesis of β-amino carbonyl compounds. We, therefore, report herein an efficient and time-saving one-pot protocol for the three-component condensation between an aldehyde, a substituted ketone, or 1,3-dicarbonyl compounds with substituted aniline using iodine-alumina (I2-Al2O3) as a catalyst under microwave irradiation. This protocol was subsequently extended to the condensation with the less reactive methyl carbamate as a nitrogen source to give β-amino carbonyl compounds which can be easily deprotected to 1,3-amino alcohols or β-amino acids [20] (Scheme 1).Scheme 1In the initial experiment, a mixture of 4-chlorobenzaldehyde (1a), acetophenone (2a), and 3-chloroaniline (3a) was refluxed in ethanol in presence of I2-Al2O3 (20 mol%). On completion of the reaction (8 h, monitored by TLC), workup and subsequent purification by column chromatography afforded the product 4a in 60% yield. The same reaction under microwave irradiation led to the formation of the desired β-amino carbonyl compound 4a(12 min) in 92% yield. In a typical experiment, when a mixture of 3-chloroaniline (3a) (3.91 mmol), 4-chlorobenzaldehyde (1a) (3.56 mmol), and acetophenone (2a) (3.91 mmol) was heated for 12 min in a microwave using I2-Al2O3 (0.71 mmol of iodine adsorbed on 1.8 g of neutral alumina, that is, 20 mol% arrived at after optimization is shown in Table 1) as a catalyst in dry ethanol at 100°C, 4a was obtained in 92% yield.Table 1
Optimization of the amount of I2-Al2O3 catalyst.
Substrate1 R1Substrate2 R2Substrate3 R5I2-Al2O3 (mol %)Time (min)Product 4Yielda/(%)4-ClC6H4C6H53-ClC6H410124a574-ClC6H4C6H53-ClC6H420124a924-ClC6H4C6H53-ClC6H420204a904-ClC6H4C6H53-ClC6H440124a91aIsolated yields.In another attempt, the same reaction mixture in neat condition under microwave irradiation in presence of I2-Al2O3 (20 mol%) catalyst yielded only 46% of compound 4a. Later, the optimized reaction condition was extended for the condensation of methyl carbamate (3f) (3.91 mmol) with benzaldehyde (1e) (3.55 mmol) and acetophenone (2a) (3.91 mmol) in presence of I2-Al2O3(20 mol%) in ethanol in a microwave. The reaction furnished the desired product 4fin 13 min with 75% yield. To study the generality of this methodology, reactions with a number of substituted aromatic aldehydes, substituted aromatic ketones, or 1,3-dicarbonyl compounds and methyl carbamate or substituted anilines were carried out. Irrespective of the substitutions on the aromatic aldehydes, acetophenones or anilines by electron withdrawing or donating groups in either ortho, meta, or para position the reaction proceeded smoothly to give the corresponding products in good to excellent yields (Table 2). However, aldehyde having nitro group substitution failed to give the desired product, where as para-nitro acetophenone (2e) condenses readily with aniline (3b) and benzaldehyde (1e) to afford the product 4e (entry 5, Table 2). On the other hand, benzaldehyde (1e) when reacted with dicarbonyl compounds such as diethyl malonate (2t) and 3-chloroanilne (3a), compound 4t was obtained in 9 min with 89% yield (entry 20, Table 2). All the β-amino carbonyl compounds (4a–4t) obtained after simple workup and purification by column chromatography was characterized by 1H, 13C NMR and IR analyses, and the results are summarized in Table 2.Table 2
I2-Al2O3 catalyzed multicomponent reaction for the preparation of β-amino carbonyl compounds.
EntrySubstrate1 R1Substrate2 (R2)/5 (R3, R4)Substrate3 R5Time (min)Product4bYielda/(%)c14-ClC6H4R2 = C6H53-ClC6H4124a9224-MeOC6H4R2 = C6H5C6H5114b90 [23]32-ClC6H4R2 = C6H54-NO2C6H4154c9043-BrC6H4R2 = C6H54-MeC6H4104d865C6H5R2 = 4-NO2C6H4C6H5124e896C6H5R2 = C6H5134f7574-MeC6H4R2 = C6H5124g6583-MeOC6H4R2 = C6H5114h7594-MeOC6H4R2 = C6H5124i75104-ClC6H4R2 = C6H5134j70114-OHC6H4R2 = C6H5134k96123,4-(MeO)2C6H3R2 = C6H5104l73134-ClC6H4R2 = 2-MeC6H4154m70144-ClC6H4R2 = 4-MeOC6H4104n65154-ClC6H4R2 = 4-BrC6H4144o72164-ClC6H4R2 = 4-OHC6H4154p6917R2 = C6H5144q68183,4-(MeO)2C6H3R3 = Me94r75R4 = Me193,4,5-(MeO)3C6H2R3 = Me154s67R4 = Me20C6H5R3 = OEt3-ClC6H494t89R4 = EtaIsolated yields. bProducts were characterized by 1H, 13C NMR and IR analyses. cReference.It is to be noted that the effect of the I2-Al2O3 as compared to molecular iodine as a catalyst is more superior as is evident from the fact that, when the reaction is carried out with meta-substituted aldehyde, such as 3-methoxybenzaldehyde, it was found that I2-Al2O3 successfully gave the products 4h, 4l, 4r, and 4s whereas the reported method using molecular iodine alone as a catalyst failed to yield the desired products [21]. Significantly, no iodination (for compound4q) was observed at the allylic double bond.The formation of theβ-amino carbonyl compounds may be explained as follows: alumina polarizes the iodine molecule and acts as an activating agent to produce a strongly electrophilic I+ species. The I+ species then catalyses in  situ generation of acylimines which is subsequently attacked by the enolizable ketone to provide the desired compound.


## 2. Conclusion

In summary, we have established a convenient and environmentally benign protocol for the synthesis ofβ-amino carbonyl compounds by using I2-Al2O3as a catalyst. In addition, this catalytic protocol has the advantages of mild reaction condition, simple workup procedure, and purification to afford the products in good yields. Due to its operational simplicity, this facile method is expected to have wider application for the preparation of β-amino carbonyl compounds.


## 3. Experimental Section

All commercially available chemicals and reagents were purchased from Aldrich and used without further purification. IR spectra were recorded on a Perkin-Elmer FT-IR instrument. The1H- and 13C-NMR spectrum were recorded on a Bruker Avance II 400 NMR machine. Unless otherwise specified, CDCl3 was used as solvent. Mass spectra were recorded with a Water ZQ-4000 equipped with ESI and APCI mass detector and CHN was done on Perkin-Elmer PE 2400 Series II. The I2-Al2O3 catalyst was prepared by the procedure reported in reference [24].General Procedure4(a–t)
A prestirred mixture of aldehyde (3.56 mmol), acetophenone, methyl acetoacetate, or diethyl malonate (3.91 mmol) and methyl carbamate or aniline (3.91 mmol) in dry ethanol (3 mL) was irradiated in a Chem Discover microwave reactor at 100°C (power 200 W), for 10–15 min, in the presence of I2-Al2O3(20 mol%). The completion of the reaction was monitored by thin layer chromatography. The reaction mixture was filtered through a bed of celite and washed the residue with ethyl acetate (3×5 mL). The filtrate was then washed with aqueous sodium thiosulfate (5%) followed by brine. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuoto give the crude mass. The crude compound was then purified by silica gel column chromatography, using ethyl acetate and hexane as eluents, to afford the β-amino carbonyl compounds in pure form.3-(4-Chlorophenyl)-3-((3-chlorophenyl)amino)-1-phenylpropan-1-one (4a, Table 2)
Off white solid; mp 98–100˚C; 1H NMR (400 MHz, DMSO-d6): δ 3.07 (1H, dd, J = 4, 17.2 Hz, CH2), 3.41 (1H, dd, J = 8.8, 17.2 Hz, CH2), 4.75–4.80 (1H, m, CH), 6.23 (2H, t, J = 6 Hz, Ar-H), 6.27 (1H, d, J = 1.2 Hz, NH), 6.38 (1H, d, J = 7.2 Hz, Ar-H), 6.75 (1H, t, J = 8 Hz, Ar-H), 7.13 (2H, d, J = 8.4 Hz, Ar-H), 7.19–7.40 (5H, m, Ar-H), 7.73 (2H, d, J = 7.2 Hz, Ar-H) ppm; 13C NMR (100 MHz, DMSO-d6): δ 46.1, 51.9, 111.4, 111.9, 115.4, 128.0, 128.3, 128.5, 128.7, 130.3, 131.4, 133.4, 136.5, 142.5, 149.1, 196.7 ppm; IR. νmax (KBr): 3398, 3062, 2925, 2900, 2853, 1676, 1599, 1518, 1489, 1293, 1089 cm−1; Elemental analysis for C21H17Cl2NO Calcd. C, 68.12; H, 4.63; N, 3.78; Found: C, 67.96; H, 4.70; N, 3.68.3-(4-Methoxyphenyl)-1-phenyl-3-(phenylamino)propan-1-one (4b, Table 2)
The spectroscopic data is in full agreement with the literature data [23].3-(2-Chlorophenyl)-3-((4-nitrophenyl)amino)-1-phenylpropan-1-one (4c, Table 2)
Yellow solid; mp 135–137°C;1H NMR (400 MHz, CDCl3): δ 3.49 (2H, d, J = 6.2 Hz, CH2), 5.38 (1H, m, CH), 5.48 (1H, d, J = 6.0 Hz, NH), 6.40 (2H, d, J = 9.2 Hz, Ar-H), 7.20–7.50 (7H, m, Ar-H), 7.67 (2H, d, J = 7.2 Hz, Ar-H), 7.91 (2H, d, J = 9.0 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 42.8, 51.6, 112.4, 126.2, 127.7, 127.8, 128.4, 128.9, 129.2, 130.2, 132.4, 134.0, 136.2, 137.7, 138.7, 151.6, 198.2 ppm; IR νmax (KBr): 3369, 3062, 2925, 2854, 1691, 1598, 1532, 1503, 1471, 1449, 1308, 1291, 1113 cm–1; Elemental anlaysis for C21H17ClN2O3 Calcd. C, 66.23; H, 4.50; N, 7.36; Found: C 66.45; H 4.43; N 7.41.3-(3-Bromophenyl)-1-phenyl-3-(p-tolylamino)propan-1-one (4d, Table 2)
White solid; mp 107–111˚C; 1H NMR (400 MHz, CDCl3): δ2.14 (3H, s, CH3), 3.39 (2H, dd, J = 6, 18 Hz, CH2), 3.61 (1H, d, J = 5.6 Hz, NH), 4.87 (1H, t, J = 6.4 Hz, CH), 6.61 (2H, d, J = 7.6 Hz, Ar-H), 6.88 (2H, d, J = 8 Hz, Ar-H), 7.02–7.52 (6H, m, Ar-H), 7.78 (2H, d, J = 7.6 Hz, Ar-H), 7.87 (1H, d, J= 8.4 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 20.6, 44.8, 59.5, 117.0, 122.9, 127.0, 128.1, 128.2, 128.7, 128.8, 129.5, 129,9, 130.4, 130.4, 131.1, 131.3, 131.6, 133.6, 136.3, 197.0 ppm; IR. νmax (KBr): 3403, 2924, 2854, 1678, 1620, 1597, 1523, 1366, 1289 cm−1; Elemental analysis for C22H20BrNO Calcd. C, 67.01; H, 5.11; N, 3.55; Found C, 67.23; H, 5.55; N, 3.24.1-(4-nitrophenyl)-3-phenyl-3-(phenylamino)propan-1-one (4e, Table 2)
White Solid; mp 145–147°C;1H NMR (400 MHz, CDCl3): δ 3.40–3.58 (2H, m, CH2), 5.16 (1H, t, CH), 6.69 (2H, d, J = 6.4 Hz, Ar-H), 6.63–6.70 (2H, m, Ar-H). 6.79–6.89 (1H, m, Ar-H), 7.14 (2H, d, J = 7.6 Hz, Ar-H), 7.26–7.29 (1H, m, Ar-H), 7.31–7.35 (2H, m, Ar-H), 7.66 (2H, d, J = 6.4 Hz, Ar-H); 7.90 (2H, d, J = 7.2 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 46.0, 53.5, 110.0, 114.8, 122.9, 124.0, 126.1, 128.0, 128.3, 128.9, 142.7, 141.3, 151.1, 196.5 ppm; IR. νmax (KBr): 3400, 3099, 3064, 2985, 2925, 2872, 1678, 1600, 1538, 1352, 1214, 1204 cm−1; Elemental analysis for C21H18N2O3: Calcd. C, 72.82; H, 5.24; N, 8.09; Found: C, 72.96; H, 5.34; N, 8.11.Methyl (3-oxo-1,3-diphenylpropyl)carbamate (4f, Table 2)
Off white solid; mp 115–120˚C; 1H NMR (400 MHz, CDCl3): δ 3.43–3.49 (2H, m, CH2), 3.66 (3H, s, COOCH3), 5.29–5.31 (1H, m, CH), 5.77 (1H, s, NH), 7.22–7.46 (7H, m, Ar-H), 7.56 (1H, t, J = 7.2 Hz, Ar-H), 7.90 (2H, d, J = 7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 30.9, 43.9, 51.7, 52.2, 126.3, 127.4, 128.1, 128.6, 128.7, 133.4, 136.6, 141.4, 156.4, 197.8 ppm; IR. νmax (KBr): 3369, 2955, 2924, 2853, 1733, 1683, 1521, 1294, 1030 cm−1; Elemental analysis for C17H17NO3: Calcd. C, 72.07; H, 6.05; N, 4.94; Found C, 72.27; H, 6.17; N, 4.86.Methyl (3-oxo-3-phenyl-1-(p-tolyl)propyl)carbamate (4g, Table 2).
Brownish solid; mp 90–94˚C; 1H NMR (400 MHz, CDCl3): δ 2.30 (3H, s, CH3), 3.44 (2H, dd, J = 6, 16.8 Hz, CH2), 3.66 (3H, s, COOCH3), 5.25–5.29 (1H, m, CH), 5.72 (1H, s, NH), 7.12 (2H, d, J = 7.6 Hz, Ar-H), 7.24 (2H, d, J = 8 Hz, Ar-H), 7.45 (1H, t, J = 7.6 Hz, Ar-H), 7.55 (2H, d, J = 7.6 Hz, Ar-H), 7.91 (2H, d, J = 7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 21.0, 44.0, 51.5, 52.2, 126.3, 128.1, 128.7, 129.3, 133.4, 136.6, 137.1, 138.3, 156.3 ppm; IR. νmax (KBr): 3305, 3068, 3013, 2994, 2947, 2923, 2909, 1714, 1690, 1551, 1276, 1050, 763 cm−1; Elemental analysis for C18H19NO3 Calcd. C, 72.71; H, 6.44; N, 4.71; Found C, 72.91; H, 6.36; N, 4.68.Methyl (1-(3-methoxyphenyl)-3-oxo-3-phenylpropyl)carbamate (4h, Table 2)
Yellowish solid; mp 100–104˚C; 1H NMR (400 MHz, CDCl3): δ 3.43 (2H, dd, J = 4.8, 16.4 Hz, CH2), 3.68 (3H, s, COOCH3), 3.78 (3H, s, COCH3), 5.25–5.30 (1H, m, CH), 5.88 (1H, d, J = 6.4 Hz, NH), 6.78 (2H, d, J = 8 Hz, Ar-H), 6.90–7.27 (2H, m, Ar-H), 7.44 (2H, t, J = 7.6 Hz, Ar-H), 7.56 (1H, t, J = 7.2 Hz, Ar-H), 7.90 (2H, d, J = 7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 43.9, 51.7, 52.3, 55.2, 112.3, 112.6, 118.5, 128.1, 128.7, 129.7, 133.4, 136.6, 156.4, 157.6, 159.7 ppm; IR. νmax (KBr): 3362, 3080, 3047, 3007, 2962, 2925, 2852, 1728, 1683, 1598, 1518, 1491, 1295, 1167, 1022 cm−1; Elemental analysis for C18H19NO4 Calcd. C, 68.99; H, 6.11; N, 4.47; Found C, 69.12; H, 6.15; N, 4.31.Methyl (1-(4-methoxyphenyl)-3-oxo-3-phenylpropyl)carbamate (4i, Table 2)
Yellowish solid; mp 145–148˚C; 1H NMR (400 MHz, CDCl3): δ 3.43 (2H, dd, J = 6.4, 16.8 Hz, CH2), 3.66 (3H, s, COOCH3), 3.77 (3H, s, COCH3), 5.24–5.25 (1H, m, CH), 5.66 (1H, s, NH), 6.84 (2H, d, J = 8.8 Hz, Ar-H), 7.26–7.28 (2H, m, Ar-H), 7.43–7.46 (2H, m, Ar-H), 7.55 (1H, t, J = 7.6 Hz, Ar-H), 7.90 (2H, d, J = 9.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 51.4, 52.2, 55.3, 114.0, 127.6, 128.1, 128.7, 133.4, 136.7, 156.3, 158.9 ppm; IR. νmax (KBr): 3296, 3074, 3022, 2994, 2966, 2948, 2906, 2844, 1709, 1687, 1555, 1513, 1280, 1251, 1048, 762 cm−1; Elemental Analysis for C18H19NO4 Calcd. C, 68.99; H, 6.11; N, 4.47; Found C, 68.89; H, 6.16; N, 4.39.Methyl (1-(4-chlorophenyl)-3-oxo-3-phenylpropyl)carbamate (4j, Table 2)
Off white solid; mp 109–112˚C; 1H NMR (400 MHz, CDCl3): δ 3.45–3.47 (2H, m, CH2), 3.66 (3H, s, COOCH3), 5.25–5.29 (1H, m, CH), 5.86 (1H, s, NH), 7.26–7.47 (6H, m. Ar-H), 7.58 (1H. t, J = 7.6 Hz, Ar-H), 7.89 (2H, d, J = 7.6 Hz, Ar-H) ppm; IR. νmax (KBr): 3311, 3061, 2953, 2853, 1693, 1545, 1274, 1052, 761 cm−1; Elemental Analysis for C17H16ClNO3 Calcd. C, 64.26; H, 5.08; N, 4.41; Found C, 64.29; H, 5.12; N, 4.53.Methyl (1-(4-hydroxyphenyl)-3-oxo-3-phenylpropyl)carbamate (4k, Table 2)
Brownish liquid;1H NMR (400 MHz, CDCl3): δ 3.40 (2H, dd, J = 6, 16.8 Hz, CH2), 3.67 (3H, s, COOCH3), 5.20–5.21 (1H, m, CH), 5.78 (1H, s, NH), 6.69 (2H, d, J = 8 Hz, Ar-H), 7.15 (2H, d, J = 8 Hz, Ar-H), 7.42–7.46 (2H, m, Ar-H), 7.56 (1H, t, J = 7.2 Hz, Ar-H), 7.90 (2H, d,J =7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 44.1, 51.5, 52.4, 115.5, 115.9, 127.6, 128.2, 128.7, 133.5, 136.5, 155.4, 156.6 ppm; IR. νmax (KBr): 3438, 3019, 1716, 1600, 1514, 1215, 1018, 768 cm−1; Elemental Analysis for C17H17NO4 Calcd. C, 68.21; H, 5.72; N, 4.68; Found C, 68.36; H, 5.63; N, 4.72.Methyl (1-(3,4-dimethoxyphenyl)-3-oxo-3-phenylpropyl)carbamate (4l, Table 2)
White solid; mp 117–120˚C; 1H NMR (400 MHz, CDCl3): δ 3.42 (2H, dd, J = 6, 16.4 Hz, CH2), 3.65 (3H, s, COOCH3), 3.83 (3H, s, COCH3), 3.84 (3H, s, COCH3), 5.25 (1H, br, CH), 5.79 (1H, s, NH), 6.79 (1H, d, J = 8.4 Hz, Ar-H), 6.88 (1H, d, J = 4.8 Hz, Ar-H), 7.42–7.46 (3H, m, Ar-H), 7.56 (1H, t, J = 7.2 Hz, Ar-H), 7.90 (2H, d, J = 7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 44.1, 51.7, 52.2, 55.9, 110.0, 111.1, 118.3, 128.1, 128.7, 133.4, 136.7, 148.3, 149.0, 156.4, 198.1 ppm; IR. νmax (KBr): 3379, 3078, 2994, 2959, 2924, 2852, 1728, 1676, 1592, 1535, 1522, 1452, 1295, 1264, 1025, 757 cm−1; Elemental Analysis for C19H21NO5 Calcd. C, 66.46; H, 6.16; N, 4.08; Found C, 66.59; H, 6.23; N, 4.16.Methyl (1-(4-chlorophenyl)-3-oxo-3-(o-tolyl)propyl)carbamate (4m, Table 2)
Off white solid; mp 110–114˚C; 1H NMR (400 MHz, CDCl3): δ 2.36 (3H, s, CH3), 3.36 (2H, dd, J = 5.6, 16.4 Hz, CH2), 3.67 (3H, s, COOCH3), 5.20–5.22 (1H, m, CH), 5.84 (1H, s, NH), 7.21–7.39 (7H, m, Ar-H), 7.53 (1H, d, J = 7.6 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 21.2, 31.0, 51.4, 52.3, 125.8, 127.8, 128.5, 128.8, 131.9, 132.2, 133.3, 137.2, 138.5, 139.9, 154.5, 194.3 ppm; IR. νmax (KBr): 3319, 3062, 3027, 2951, 2930, 2853, 1690, 1678, 1547, 1491, 1345, 1273, 1053 cm−1; Elemental Analysis for C18H18ClNO3 Calcd. C, 65.16; H, 5.47; N, 4.22; Found C, 65.21; H, 5.53; N, 4.26.Methyl (1-(4-chlorophenyl)-3-(4-methoxyphenyl)-3-oxopropyl)carbamate (4n, Table 2)
White solid; mp 120–124˚C; 1H NMR (400 MHz, CDCl3): δ 3.36 (2H, dd, J = 6, 16.8 Hz, CH2), 3.66 (3H, s, COOCH3), 3.86 (3H, s, COCH3), 5.21–5.26 (1H, m, CH), 5.94 (1H, s, NH), 6.91 (2H, d, J = 8.8 Hz, Ar-H), 7.25–7.30 (4H, m, Ar-H), 7.86 (2H, d, J = 9.2 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 43.2, 51.3, 52.3, 55.5, 113.9, 127.8, 128.7, 129.6, 130.4, 133.1, 140.1, 156.4, 163.9 ppm; IR. νmax (KBr): 3307, 3061, 3008, 2951, 2840, 1685, 1668, 1604, 1540, 1421, 1260, 1045 cm−1; Elemental Analysis for C18H18ClNO4 Calcd. C, 62.16; H, 5.22; N, 4.03; Found C, 62.13; H, 5.24; N, 4.11.Methyl (3-(4-bromophenyl)-1-(4-chlorophenyl)-3-oxopropyl)carbamate (4o, Table 2)
White solid; mp 87–91˚C; 1H NMR (400 MHz, CDCl3):δ 3.4 (2H, dd,J = 6, 17.2 Hz, CH2), 3.67 (3H, s, COOCH3), 5.23–5.28 (1H, m, CH), 5.75 (1H, s, NH), 7.23–7.29 (4H, m, Ar-H), 7.59 (2H, d, J = 8.8 Hz, Ar-H), 7.75 (2H, d, J = 8.8 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 45.7, 51.1, 52.3, 127.8, 128.8, 128.9, 129.6, 130.9, 132.1, 133.3, 135.1, 156.3, 190.9 ppm; IR. νmax (KBr): 3319, 3072, 2926, 2853, 1688, 1586, 1540, 1264, 1199, 1012 cm−1; Elemental Analysis for C17H15BrClNO3 Calcd. C, 51.47; H, 3.81; N, 3.53; Found C, 51.39; H, 3.76; N, 3.58.Methyl (1-(4-chlorophenyl)-3-(4-hydroxyphenyl)-3-oxopropyl)carbamate (4p, Table 2)
Off white solid; mp 100–104˚C; 1H NMR (400 MHz, CDCl3): δ 3.36–3.51 (2H, m, CH2), 3.65 (3H, s, COOCH3), 5.23 (1H, s, CH), 6.85 (2H, d, J = 8.4 Hz, Ar-H), 7.27–7.30 (2H, m, Ar-H), 7.52 (2H, d, J = 8 Hz, Ar-H), 7.78 (2H, d, J = 8.4 Hz, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 52.4, 65.9, 115.5, 127.8, 128.7, 129.5, 130.7, 130.9, 132.2, 133.1, 156.6, 161.3, 190.9 ppm; IR. νmax (KBr): 3321, 2955, 2925, 2853, 1693, 1669, 1598, 1540, 1278, 1169, 835 cm−1; Elemental Analysis for C17H16ClNO4 Calcd. C, 61.18; H, 4.83; N, 4.20; Found C, 61.13; H, 4.77; N, 4.13.(E)-Methyl (5-oxo-1,5-diphenylpent-1-en-3-yl)carbamate (4q, Table 2)
Brownish viscous liquid;1H NMR (400 MHz, CDCl3): δ 3.34 (2H, dd, J = 5.6, 17.2 Hz, CH2), 3.67 (3H, s, COOCH3), 4.85–4.88 (1H, m, CH), 5.69 (1H, s, NH), 6.33 (1H, dd, J = 6.4, 16 Hz, CH=), 6.57 (1H, d, J = 16 Hz, CH=), 7.19–7.41 (5H,m, Ar-H), 7.46 (1H, t, J = 7.6 Hz, Ar-H), 7.56 (2H, d, J = 7.6 Hz, Ar-H), 7.95 (2H, d, J = 7.2 Hz, Ph) ppm; 13C NMR (100 MHz, CDCl3): δ 43.1, 50.0, 52.2, 126.5, 127.7, 128.1, 128.5, 128.7, 131.1, 133.5, 136.4, 136.7, 156.4, 195.6 ppm; IR. νmax (KBr): 3434, 3023, 2977, 2895, 1712, 1686, 1519, 1424, 1221, 1045 cm−1; MS (ES+) for C19H19NO3 m/z (M + H)+ 310.14, found (M + H)+ 310.5; Elemental Analysis for C19H19NO3 Calcd. C, 73.77; H, 6.19; N, 4.53; Found C, 73.71; H, 6.21; N, 4.57.Methyl 2-((3,4-dimethoxyphenyl) ((methoxycarbonyl)amino)methyl)-3-oxobutanoate (4r, Table 2)
White solid; mp 140–144˚C; 1H NMR (400 MHz, (CD3)2CO-d6): δ 2.11 (3H, s, COCH3), 3.40 (3H, s, COOCH3), 3.65 (3H, s, COOCH3), 3.67 (6H, s, COCH3), 4.11–4.12 (1H, m, CH), 5.21–5.26 (1H, m, CH), 6.7–6.94 (3H, m, Ar-H) ppm; 13C NMR (100 MHz, (CD3)2CO-d6):δ 30.2, 49.8, 52.3, 52.4, 52.5, 63.3, 108.9, 110.4, 111.1, 118.6, 126.9, 130.1, 132.0, 156.3, 167.7, 190.9 ppm; IR. νmax (KBr): 3366, 3050, 3002, 2960, 2839, 1714, 1594, 1519, 1441, 1026 cm−1; Elemental Analysis for C16H21NO7 Calcd. C, 56.63; H, 6.24; N, 4.13; Found C, 56.53; H, 6.28; N, 4.18.Methyl 2-(((methoxycarbonyl)amino)(3,4,5-trimethoxyphenyl)methyl)-3-oxobutanoate (4s, Table 2)
White solid; mp 157–160˚C; 1H NMR (400 MHz, CDCl3): δ 2.18 (3H, s, CH3), 3.67 (3H, s, COOCH3), 3.72 (3H, s, COOCH3), 3.81 (3H, s, COCH3), 3.85 (6H, s, COCH3), 4.01 (1H, d, J = 5.2 Hz, CH), 5.37–5.40 (1H, m, CH), 6.16 (1H, d, J = 8.8 Hz, NH), 6.50 (2H, s, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 31.0, 52.4, 52.9, 54.7, 56.3, 60.8, 62.9, 103.6, 106.7, 135.2, 137.5, 153.3, 167.6, 203.4 ppm; IR. νmax (KBr): 3370, 2995, 2956, 2927, 2851, 1728, 1711, 1592, 1540, 1297, 1127 cm−1; MS (ES+) for C17H23NO8 m/z (M + Na)+ 392.14, found (M + Na)+ 392.4; Elemental Analysis for C17H23NO8 Calcd. C, 55.28; H, 6.28; N, 3.79; Found C, 55.31; H, 6.24; N, 3.83.Diethyl 2-((3-chlorophenylamino)(phenyl)methyl)malonate (4t, Table 2)
White solid; mp 113–114°C;1H NMR (400 MHz, CDCl3): δ 1.09 (3H, t, J = 7.2 Hz, CH3), 1.16 (3H, t, J = 7.2 Hz, CH3), 3.86 (1H, d, J = 5.2 Hz, CH), 4.12 (2H, q, J = 7.2 Hz, CH2), 4.04 (2H, q, J = 7.2 Hz, CH2), 5.22 (1H, d, J = 5.6 Hz, CH), 5.64 (1H, br. s, NH), 6.49 (1H, d, J = 8.8 Hz, Ar-H), 6.59 (1H, s, Ar-H), 6.70 (1H, d, J = 8.8 Hz, Ar-H), 7.00 (1H, t, J = 8.8 Hz, Ar-H), 7.26–7.35 (5H, m, Ar-H) ppm; 13C NMR (100 MHz, CDCl3): δ 13.8, 14.0, 56.7, 57.8, 61.5, 61.8, 111.8, 113.3, 117.6, 126.5, 127.8, 128.6, 130.0, 134.9, 139.0, 147.8, 167.0, 168.0 ppm; IR. νmax (KBr): 3376, 2990, 2980, 2933, 2800, 1753, 1568, 1540, 1309, 1196 cm–1; Elemental analysis for C20H22ClNO4 Calcd. C 63.91; H 5.90; N 3.73; Found C 63.71; H 5.83; N 3.61.



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*Source: 514620-2011-03-01.xml*