# Superacid-Induced Reactions of Nefopam

Authors: Larecia Knoecer; Daniel DeSchepper; Douglas A. Klumpp
Journal: Organic Chemistry International
 (2010)

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## Abstract

The analgesic drugnefopam reacts in superacidic media to form a dicationic superelectrophiles by ring opening.  The dication species is capable of reacting with arenes in Friedel-Crafts-type conversions. This chemistry is used to prepare novel derivatives of nefopam.


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## Body


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*Source: 496818-2010-06-13.xml*