# Early versus Delayed Laparoscopic Cholecystectomy for Acute Cholecystitis: A Prospective Randomized Trial

Authors: Sushant Verma; P. N. Agarwal; Rajandeep Singh Bali; Rajdeep Singh; Nikhil Talwar
Journal: ISRN Minimally Invasive Surgery
 (2013)

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## Abstract

Introduction. Very few studies demonstrate the feasibility of laparoscopic cholecystectomy for acute cholecystitis. However, most surgeons prefer to delay surgery in the acute phase. The aim of this prospective randomized study was to evaluate the safety and feasibility of laparoscopic cholecystectomy for acute cholecystitis. Materials and Methods. Between August 2010 and March 2012, 30 patients with a diagnosis of acute cholecystitis underwent early laparoscopic cholecystectomy within 72 h of admission. This study group was compared with a control group of 30 patients of acute cholecystitis, who underwent delayed laparoscopic cholecystectomy after an initial period of conservative treatment. Results. There was no significant difference in the conversion rates (3 early versus 2 delayed), postoperative analgesia requirements, postoperative pain scores, or duration of postoperative stay (1.67 days early versus 1.47 days delayed). However, duration of surgery was significantly more in the early group (65.78 minutes early versus 56.83 minutes delayed).  Surgery was abandoned in 2 patients from the early group because of difficult anatomy. No complications and mortality were seen in either group. Conclusions. Early laparoscopic cholecystectomy for acute cholecystitis is safe and feasible, offering the additional benefit of a shorter hospital stay. It should be offered to patients with acute cholecystitis, provided the surgery is performed within 72 h from the onset of symptoms.


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## Body

## 1. Introduction

Laparoscopic cholecystectomy is the most common laparoscopic surgery performed in the world [1]. The traditional treatment (initial) of acute calculus cholecystitis includes bowel rest, intravenous hydration, correction of electrolyte abnormalities, analgesia, and intravenous antibiotics. Following this treatment, patients with uncomplicated disease are managed on outpatient basis and are called for laparoscopic cholecystectomy after a period of 6–8 weeks.  Laparoscopic cholecystectomy is avoided for acute cholecystitis due to concerns about the potential hazards of complications, especially common bile duct injury and a high conversion rate to open cholecystectomy [2]. Initial studies, however have shown that early laparoscopic cholecystectomy can be done during acute cholecystitis [3–5]. Since most surgeons prefer to delay surgery during the acute phase, we undertook a prospective randomized study to compare early and delayed laparoscopic cholecystectomy in the treatment of acute cholecystitis.


## 2. Materials and Methods

The study was conducted at the Department of Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, from August 2010 to March 2012. The study population included patients between 18 and 60 years of age with acute calculus cholecystitis (ASA grade 1–3) presenting to surgery emergency and OPD of Lok Nayak Hospital, New Delhi. The study included 30 consecutive patients presenting with acute calculus cholecystitis, which were compared with a control group of 30 patients of acute calculus cholecystitis undergoing delayed laparoscopic cholecystectomy.  Randomization of patients was done using a table of random numbers. Diagnosis of acute cholecystitis was based on the following four diagnostic criteria: acute upper abdominal pain with tenderness under the right costal margin, fever more than 37.5°C, leukocytosis more than 10,500/mm3, and ultrasonographic evidence of acute cholecystitis (thickened gallbladder wall, edematous gallbladder wall, presence of gallstones, and pericholecystic fluid collection). Patients of acute cholecystitis with ASA grade >3, who had pancreatitis and common bile duct stones, were excluded. The study protocol was approved by the Hospital Ethics Committee and an informed consent was obtained from every patient. In the early group, laparoscopic cholecystectomy was performed within 72 h of admission, whereas in the delayed group laparoscopic cholecystectomy was done after 6 to 8 weeks.Laparoscopic cholecystectomy was performed using the standard 4 port technique. Modifications were used in the surgical technique in both groups (Table1).Table 1
Modification of the operative technique.
Modification
Early group
Delayed group
P value
Gallbladder decompression
15
3
0.022
Retrieval bag
8
2
0.013
Subhepatic drain
5
1
0.012Postoperatively, the patients were allowed oral intake 6–12 h after surgery provided they had no nausea or vomiting. Pain relief was obtained by intramuscular diclofenac (75 mg) injection, which was changed to tablet form once patient was allowed orally. Postoperative pain assessment was performed by visual analog scale (VAS). The patients were discharged once the patients were afebrile and taking nutrition orally.In the intraoperative period, the following parameters were evaluated: duration of surgery starting from incision for the port to closure of port sites, gall bladder perforation, common bile duct injury, conversion to open cholecystectomy and requirement of drains.In the postoperative period, the following parameters were evaluated: analgesic requirement, pain scoring using visual analogue scale, duration of postoperative hospital stay, wound related complications.Statistical analysis was performed using pairedt-test and chi-square test. SPSS version 17 was used to determine the P value (P value less than 0.05 was considered significant).


## 3. Results

During the study period, a total 60 patients were evaluated: 30 patients in the early group and 30 patients in the delayed group. The two groups were well matched in terms of age and sex, as well as clinical and laboratory parameters.More modifications in the operation technique (Table1) and a longer operation time were required in the early group than in the delayed group. The mean operating time was 65.78 min in the early group and 56.83 min in the delayed group. The difference in operation time was statistically significant (P value: 0.046).Three patients in early group and 2 patients in delayed group underwent conversion to open surgery (P value: 0.780). The main reasons for conversion in the early cases were unclear Calot’s triangle anatomy and hemorrhage. The main reason for conversion in the delayed group was hemorrhage.Surgery was abandoned in 2 patients from the early group because of difficult anatomy.The pain scores, assessed by the visual analogue scale at 12 hours, 24 hours, and 7 days after surgery, in the two groups were statistically insignificant (P value: 0.115). There was no statistically significant difference (P value: 0.115) in the analgesia requirement of the two groups postoperatively.The mean duration of postoperative stay in the early group was 1.67 days as compared to 1.47 days in the delayed group. The difference was statistically insignificant (P value: 0.379). The overall comparison of the patients in the early and delayed groups is shown in Table 2.Table 2
Overall comparison of the patients in the early and delayed groups.
Early group (n=30)
Delayed group (n=30)
P value
Age (years)
31.73
32.8
0.570
Sex (M : F)
4 : 26
2 : 28
0.114
Duration of acute symptoms (h)
36.8
37.7
0.088
Operating time (min)
65.78
56.83
0.046
Postoperative stay (days)
1.67
1.47
0.379
Conversion rate
3
2
0.780


## 4. Discussion

The common approach for management of acute calculous cholecystitis consists of an initial control of inflammation followed by interval cholecystectomy after a period of 6–8 weeks. Arguments made against early laparoscopic cholecystectomy include a high conversion rate and complications. Various studies have reported high conversion rates, ranging from 6% to 35% for early laparoscopic cholecystectomy in acute cholecystitis [6–8]. It is, therefore, argued that if delayed laparoscopic cholecystectomy leads to a technically easier surgery with a lower conversion rate, it may be a better treatment option for acute cholecystitis. However, there is an increased risk of gallstone-related morbidity during the waiting period for cholecystectomy. In our study, both the early and delayed groups had similar conversion rates. In the early stages, 2 cases in the early group were abandoned due to difficult anatomy.Most surgeons agree that timing of the procedure is an important factor in determining outcome. Ideally, the surgery should be performed within the “golden 72 h” from the onset of symptoms [9].In our study, early surgery was performed within this golden period.The technical difficulty of laparoscopic cholecystectomy is related to operative findings during early surgery. A distended and edematous gall bladder is commonly seen in cases of acute cholecystitis. On the basis of our experience, we believe that certain key points must be kept in mind when laparoscopic surgery is performed for acute cholecystitis. For good exposure of Calot’s triangle, decompression of the gallbladder should be done early because this allows better grasping and retraction of the gallbladder. The other technical rules call for the use of a suction-irrigation device for dissection and the use of a retrieval bag to remove spilled stones and perforated gallbladder. In our study, decompression of the gallbladder was required for 50% of the patients in the early group. Stone spillage was seen in 25% of the cases, which was removed by using retrieval bags. A subhepatic drain was required for 20% of the early cases.Our experience supports the belief that the inflammation associated with acute cholecystitis creates an edematous plane around the gallbladder, thus facilitating its dissection from the surrounding structures. Waiting for the inflamed gallbladder to “cool down” allows maturation of the surrounding inflammation and results in organization of the adhesions, leading to scarring and contraction, which make the dissection more difficult.The postoperative pain scores and analgesia requirements were similar in the two groups. Longer operation times were required in the early group than in the delayed group.


## 5. Conclusion

The morbidity of laparoscopic cholecystectomy for patients with acute cholecystitis is not reduced by a period of initial conservative treatment. For surgeons with adequate experience, the optimal timing of laparoscopic cholecystectomy for treatment of acute cholecystitis is within 72 hours of admission.



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