# Serotonin 5-HT2A Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases

Authors: Charles D. Nichols
Journal: Cardiovascular Psychiatry and Neurology
 (2009)

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## Abstract

There are high levels
of comorbidity between neuropsychiatric and
cardiovascular disorders. A key molecule central
to both cognitive and cardiovascular function is
the molecule serotonin. In the brain, serotonin
modulates neuronal activity and is actively
involved in mediating many cognitive functions
and behaviors. In the periphery, serotonin is
involved in vasoconstriction, inflammation, and
cell growth, among other processes.
It is hypothesized that one component of the serotonin system, the5-HT2A
receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders.
Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs. In the periphery, 5-HT2A  receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.


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## Body


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