# Epidemiology of Acute Kidney Injury in the Intensive Care Unit

Authors: James Case; Supriya Khan; Raeesa Khalid; Akram Khan
Journal: Critical Care Research and Practice
 (2013)

---

## Abstract

The incidence of acute kidney injury (AKI) in the intensive care unit (ICU) has increased during the past decade due to increased acuity as well as increased recognition. Early epidemiology studies were confounded by erratic definitions of AKI until recent consensus guidelines (RIFLE and AKIN) standardized its definition. This paper discusses the incidence of AKI in the ICU with focuses on specific patient populations. The overall incidence of AKI in ICU patients ranges from 20% to 50% with lower incidence seen in elective surgical patients and higher incidence in sepsis patients. The incidence of contrast-induced AKI is less (11.5%–19% of all admissions) than seen in the ICU population at large. AKI represents a significant risk factor for mortality and can be associated with mortality greater than 50%.


---

## Body

## 1. Introduction

Acute kidney injury (AKI) (also referred to as acute renal failure) reflects a broad spectrum of clinical presentations ranging from mild injury to severe injury that may result in permanent and complete loss of renal function. The range of severity and variety of causes of AKI has resulted in multiple classification systems complicating diagnosis and subsequent management.  The lack of consensus has resulted in a broad range of estimated prevalence in the intensive care unit (ICU) ranging from 1% to 70% depending on the criteria used [54, 55].  The underlying mechanisms of AKI include a decrease in the kidney’s ability to excrete nitrogenous waste, manage electrolytes, regulate intravascular volume, and assist with maintenance of the acid-base status.  The clinical effects of AKI depend on the clinical situation but almost invariably increase mortality and morbidity [56, 57].


## 2. Measurement of Renal Function

Definitions of AKI depend on measurement of serum creatinine (Cr) as a surrogate marker for the glomerular filtration rate (GFR).  While inulin remains the gold standard for determination of GFR, it is rarely performed due to the need for continuous intravenous infusion and considerable laboratory resources [58].  Calculation of the GFR is performed based on the serum Cr value despite the fact that Cr has a complex metabolism and many factors can alter serum Cr values [59–64].  High protein intake and medications may increase Cr production independently of renal filtration.  Furthermore, Cr secretion in the proximal renal tubules [65, 66]  may account for as much as 60% of Cr elimination in patients with renal disease [67].  Medications such as cimetidine, quinidine, and trimethoprim inhibit this process [65], whereas hemodialysis can increase it [68].  Direct measurement of Cr clearance to determine renal function is also unreliable in critically ill patients due to the increased secretion of Cr in the renal tubules [67] and significant overestimation of GFR [58].


## 3. Defining AKI

Despite its first reports in the medical literature starting in 1917 described as “war nephritis” [69], AKI research was plagued by inconsistent definitions (as many as 35 different definitions [70]) until the Acute Dialysis Quality Initiative (ADQI) published the Risk, Injury, Failure, Loss, End-Stage (RIFLE) criteria in 2004 which defined AKI in terms of changes in serum Cr from baseline as well as urine output [1] (Table 1). Baseline Cr must be estimated in patients in which it is not known.  Formulas estimating GFR may overestimate it in obese patients due to the overestimation of muscle mass.  This can be alleviated by using the MDRD equation which incorporates body mass index to help nullify this effect [71]; however, estimation of baseline Cr values is still not reliable when used in ICU patients with AKI [72].Table 1
Definitions of AKI.
Serum Cr criteria
Urine output criteria
RIFLE [1]
R (Risk)
Increase in serum Cr × 1.5 or GFR decrease >25%
<0.5 mL/kg/h for 6 hours
I (Injury)
Increased serum Cr × 2 or GFR decrease >50%
<0.5 mL/kg/h for 12 hours
F (Failure)
Increase in serum Cr × 3, GFR decrease >75%, or serum Cr > 4 mg/dL
<0.3 mL/kg/h for 24 hours or anuria for 12 hours
AKIN [2]
Stage 1
Increase in serum Cr of ≥0.3 mg/dL or increase to ≥150–200% from baseline
<0.5 mL/kg/h for more than 6 hours
Stage 2
Increase in serum Cr to >200–300% from baseline
<0.5 mL/kg/h for more than 12 hours
Stage 3
Increase in serum Cr to >300% from baseline(or serum Cr ≥ 4.0 mg/dL with an acute increase of ≥0.5 mg/dL)
<0.3 mL/kg/h for 24 hours or anuria for 12 hoursSubsequent research by Chertow et al. [57] suggested that even small changes in serum Cr were associated with increased mortality; so, the Acute Kidney Injury Network (AKIN) proposed more sensitive guidelines for the diagnosis of AKI [2] (Table 1).  Multiple subsequent comparisons of sensitivity and prognosis of RIFLE and AKIN criteria have revealed conflicting results as to which method is superior although the majority of clinical data reflects RIFLE criteria [6, 17, 30, 56, 73–75].


## 4. Epidemiology of AKI

Clinical studies assessing the exact incidence of AKI in the ICU (Table2) proved sparse and were often complicated by differing criteria for the definition of AKI, especially prior to the adoption of the RIFLE and AKIN classifications.  Furthermore, clinicians frequently underreport the incidence of AKI in their patients with one study showing that discharge summaries reported renal insufficiency in only 13% of affected patients [76].  Population-based analyses vary widely between 140 and 2880 cases per million population yearly with a 400% increase between 1988 and 2002 [77–81].Table 2
Summary of original reports describing the incidence of AKI.
Author
no. of subjects
Single/multicenter
Patient population
AKI definition used
AKI incidence (%)
Mortality endpoint
Mortality (%)
Thakar et al. [3]
325,395
Multi
Mixed
RIFLE
22
ICU
10.9
Ostermann an Chang [4]
41,972
Multi
Mixed
RIFLE
35.8
ICUHospital
10.212.9
Gammelager et al. [5]
30,762
Multi
Mixed
RIFLE
15.6
30 days
40
Joannidis et al. [6]
16,784
Multi
Mixed
RIFLE
35.5
Hospital
36.4
Mandelbaum et al. [7]
14,524
Single
Mixed
AKIN
57
ICUHospital
7.19.1
Hoste et al. [8]
5383
Single
Mixed
RIFLE
67.2
Hospital
13.3
Cruz et al. [9]
2164
Multi
Mixed
RIFLE
10.8
ICU
36.3
Samimagham et al. [10]
1026
Single
Mixed
RIFLE
21.7
1 year
492.5 RRT at 90 d
Fonseca Ruiz et al. [11]
794
Single
Mixed
AKIN
39.8
ICUHospital
25.432.1
Piccinni et al. [12]
576
Multi
Mixed
RIFLE
42.7
ICU
29
Medve and Gondos [13]
459
Single
Mixed
AKIN
24.4
ICUHospital
39.349.1
Samimagham et al. [10]
235
Single
Mixed
AKIN
31.1
ICU
72.6
Yue et al. [14]
191
Single
Mixed
AKIN
35.5
ICU
48
Abosaif et al. [15]
183
Single
Mixed
RIFLE
ICU
47.5
Yegenaga et al. [16]
139
Single
Mixed
RIFLE
56.8
UKN
37.4
Bagshaw et al. [17, 18]
120,123
Multi
Sepsis
RIFLE versus AKIN
36.137.1
Hospital
RIFLE: 24.2AKIN: 24.5
Kim et al. [19]
291
Single
Severe sepsis/Septic shock
RIFLE versus AKIN
RIFLE: 62.9AKIN: 65.6
28 days
RIFLE: 58.5AKIN: 57.6
Lopes et al. [20]
182
Single
Sepsis
RIFLE
37.4
NS
37.4
Lerolle et al. [21]
35
Single
Septic shock
RIFLE
65.8
28 days
62.8
Coca et al. [22]
304
Single
Burn
RIFLE
26.6
NS
7.6
Lopes et al. [23]
126
Single
Burn
RIFLE
35.7
NS
17.5
Palmieri et al. [24]
60
Single
Burn
RIFLE
53.3
UKN
34.4
Bagshaw et al. [25]
9449
Multi
Trauma
RIFLE
18.1
Hospital
16.7
Costantini et al. [26]
571
Single
Trauma
AKIN
29.8
Hospital
15.9
Gomes et al. [27]
436
Single
Trauma
RIFLE
50
ICUHospital
8.210.8
Lin et al. [28]
46
Single
ECMO
RIFLE
78
Hospital
60.9
Englberger et al. [29]
951
Single
Tricuspid valve surgery
RIFLE
30
30 days
5.5
Englberger et al. [30]
851
Single
Thoracic aortic surgery
RIFLE
17.7
30 days
1.3
Kuitunen et al. [31]
813
Single
Cardiac surgery
RIFLE
19.3
90 days
3.2
Kramer et al. [32]
668
Multi
Cardiac surgery
AKIN
Surgery: 33.7Cath + surgery: 50.2
NS
NS
Yan et al. [33]
509
Single
Cardiac surgery
RIFLE
32.8
Hospital
4.3
Mariscalo et al. [34]
414
Multi
Aortic root repair
RIFLE
16.7
Hospital
2.7
Roh et al. [35]
98
Single
Thoracic aorta graft placement
RIFLE
54
30 days
5.1
Machado et al. [36]
817
Single
CP bypass
RIFLE
48.5
30 days
12.6
Sirvinskas et al. [37]
179
Single
CP bypass
RIFLE
10.6
NS
NR
O’Riordan et al. [38]
300
Multi
OLT
RIFLE
36.8
NS
NS
Biagioni et al. [39]
144
Single
OLT versus NEAS
RIFLE
OLT: 29NEAS: 47
ICU
OLT: 29NEAS: 51
Guitard et al. [40]
97
Single
OLT
RIFLE
63.8
UKN
UKN
Medve and Gondos [13]
295
Multi
Major noncardiac surgery
AKIN
18.1
ICU
33.3
Tallgren et al. [41]
69
Single
Elective infra-renal AAA surgery
RIFLE
22
Hospital
1.4
Hoste et al. [42]
787
Single
CIN
UKN
16.3
28 days1 year
13.135.9
Lakhal et al. [43]
299
Single
CIN
AKIN
14
ICU
18
Rashid et al. [44]
139
Single
CIN
RIFLE
11.5
ICU
31
Valette et al. [45]
101
Single
CIN/Surgical
RIFLE versus AKIN
RIFLE: 19AKIN: 19
ICU
RIFLE: 26.3AKIN: 31.6
Chua et al. [46]
105
Single
ROSC following cardiac arrest
RIFLE
PRCS: 51.7No PRCS: 6.4
ICU
PCRS: 46.6No PCRS: 27.7
Hospital
PCRS: 51.7No PCRS: 34
Cholongitas et al. [47]
412
Single
Cirrhosis
RIFLE
50
6 weeks
61.2
Hata et al. [48]
376
Single
ADHF
RIFLE
73.1
Hospital
10.5
Martin-Leoches et al. [49]
661
Multi
H1N1
AKIN
17.7
ICU
44.1
Jung et al. [50]
221
Multi
H1N1
RIFLE
22.6
30 days
17.2
Nin et al. [51]
84
Multi
H1N1
RIFLE
51
28 days
51.2
Abdulkader et al. [52]
47
Single
H1N1
RIFLE
53
Hospital
19.1
Chacko et al. [53]
31
Single
H1N1
RIFLE
3.2
28 days
16.1
Mixed: combined medical and surgical patients.  RRT: renal replacement therapy.  ECMO: extracorporeal membrane oxygenation.  OLT: orthotopic liver transplant.  NEAS: non-emergent abdominal surgery.  CP: cardiopulmonary.  NS: not specified.  UKN: unable to determine due to inability to access source.  AAA: abdominal aortic aneurysm.  CIN: contrast-induced nephropathy.  ROSC: return of spontaneous circulation.  PRCS: post-resuscitation cardiogenic shock.  ADHF: acute decompensated heart failure.The incidence of AKI in hospitalized patients has also increased during the same time period from 4.9% in 1983 [82] to 7.2% in 2002 [83] to as much as 20% in 2012 [84].  This may partly be due to the definitions of AKI becoming more time sensitive and may reflect an increase in detection rather than an overall increase in incidence in disease.  Due to the inconsistency of AKI definitions, the remainder of this paper will focus on articles published after release of the RIFLE criteria in 2004.Many risk factors have been identified for the development of AKI including hypotension, pulmonary disease, liver failure, sepsis, hypovolemia, increased age, hypertension, preexisting renal disease, heart failure, bleach injection, and many medications (ACE inhibitors, vasopressors, aminoglycosides, NSAIDs, etc.) [17–21, 45, 85–93].


## 5. Causes of AKI

Causes of AKI are frequently categorized as prerenal, intrinsic renal, and postrenal.  This classification system oversimplifies the overlapping pathologic mechanisms underlying AKI.  Renal parenchymal tissue hypoperfusion due to hypovolemia or hypotension may initially cause a reversible increase in Cr.  As cellular dysfunction continues, renal tubular cells may sustain ischemic injury which may persist after correction of the initial hypoperfusion state thereby changing from a prerenal azotemia to acute tubular necrosis.  Rachoin et al.  demonstrated that ICU patients with AKI and a blood urea nitrogen : Cr ratio greater than 20 : 1 had increased mortality suggesting that prerenal azotemia is not benign in ICU patients [94].  Acute tubular necrosis (ATN) is the most common form of intrinsic renal failure in the ICU comprising as much as 88% of all cases of AKI [95, 96].   Only one study describes postrenal AKI [97].   Two centers with a combined capacity of over 850 beds only identified 54 patients over a 13-year period suggesting a low overall incidence.  Many causes of AKI in ICU patients likely represent multifactorial etiologies [96].


## 6. Contrast-Induced AKI

The administration of intravenous contrast prior to computed tomography (CT) scanning has been associated with the development of AKI.  Overall incidence of contrast-induced AKI in ICU patients ranged from 11.5% to 19% [42–45]  and mortality from 13.1% to 35.9%, much lower than reported in studies not involving intravenous contrast.  Decreased mean arterial pressure, vasopressor usage, diuretics, increased age, and elevated baseline Cr are all associated with increased risk of AKI [42, 44].


## 7. Medical Patients

ICUs have seen an increase in admissions involving AKI ranging from 13% up to 78% [98–101].  Most studies have mixed surgical and nonsurgical populations.  In 2002, Metnitz et al. published a series of ICU admissions comprised of over 17,000 patients (medical, surgical, and mixed ICUs) from 30 Austrian ICUs comprised of 50.4% medical admissions [102].  The primary endpoint defined as the need for renal replacement therapy (RRT) was noted in 4.9% of all ICU admissions (5.6% of medical ICU admissions and 4.5% of surgical ICU admissions).  The most common reasons for admission that resulted in RRT were respiratory disease, sepsis, abdominal surgery, cardiovascular surgery, and surgery not otherwise specified.


## 8. Surgical Patients

Data from surgical populations show a similar incidence of postoperative AKI generally ranging from 16.7% to 30% [29, 103].  One study examining heart transplants revealed a 70% incidence of AKI in 54 patients, but this data may have been due to an increased acuity in both donors and recipients reflected as an overall mortality of 28% [55].  Roh et al. [35] reported 54% incidence of AKI in 98 patients following surgery for acute  aortic dissection, 96% of which underwent emergent repair. Of these patients, 75% underwent moderate hypothermia during their procedure; however, hypothermia alone has not been shown to increase the incidence of AKI in thoracic aortic surgery [104]. Administration of intravenous contrast frequently precipitates AKI and also increases the risk of perioperative AKI beyond what would be expected from either surgery or percutaneous coronary intervention if both are performed during the same hospitalization, 33% versus 50% [32].  Few studies describe postoperative AKI in noncardiac/nonvascular patients.  A Hungarian study examined 295 adults admitted to the ICU after major noncardiac surgery and found a similar 18.1% incidence of AKI [13].  However, 1129 patients undergoing lung resection surgery had an overall 5.9% incidence of AKI, 88% of which were classified as stage 1 by AKIN criteria [105].


## 9. Special Patient Populations

Multiple patient populations deserve special discussion regarding their risks for developing AKI.Trauma. Historically, trauma patients are younger than many other hospital populations, but as the median age of trauma patients increases, their incidence of AKI does not vary significantly from other ICU populations [106].  A post hoc analysis of the “Inflammation and the Host Response to Injury” dataset revealed a 26% incidence of AKI based on RIFLE criteria [107].Sepsis. Severe sepsis, often complicated by renal hypoperfusion in septic shock, is characterized by a profound inflammatory milieu and associated dysfunction of multiple organ systems.  Rates of AKI reported in septic patients range from 13% up to >64.4% [49–51, 87, 108, 109]. The toxic effects of sepsis on AKI do not appear to be specific to bacterial or fungal pathogens.  The 2009 H1N1 influenza pandemic demonstrated that viral infections caused significant rates of AKI (up to 51%) sometimes exceeding those seen in more common infections [49–53]. Of note, delays in the administration of appropriate antibiotics are associated with the highest incidence of sepsis-induced AKI.  A 6.0 h versus 4.3 h delay in antibiotics resulted in an odds ratio of 1.14 (95% CI 1.10–1.20, P<0.001) per hour delay for the development of AKI [87].  Furthermore, current sepsis resuscitation guidelines advocate aggressive volume resuscitation for patients presenting with severe sepsis in an effort to improve overall survival [110]. Little data exists describing the renal effects of this resuscitation; however, one study demonstrated an increase in AKI developing within the first 2 days of ICU admission in those patients with a positive fluid balance [111].  Payen et al. performed a post-hoc analysis of the Sepsis Occurrence in Acutely Ill Patients (SOAP) trial to assess the effects of fluid resuscitation on the development of AKI.  Septic patients in the SOAP trial received significantly more fluid than their nonseptic counterparts during the first 72 hours of ICU admission (1.8±5.0 versus 0.51±3.5 L).  Early, aggressive volume resuscitation can improve outcomes [112, 113]; however, patients with a more positive fluid balance subsequently developed AKI more frequently than patients that had a less positive balance [114] suggesting that the benefits of fluid administration may be time sensitive.H1N1. Little data regarding the incidence of AKI in patients with influenza A infection had been published prior to the H1N1 pandemic in 2009.  Multiple case reports of rhabodmyolysis exist, but no systematic analyses of incidence have been published [115–119].  Therefore, it is impossible to determine whether the H1N1 strain uniquely caused AKI or whether the many reports of AKI reflect the underlying severity of the patients’ illness upon their arrival in the ICU [49–53].Burns. Victims of severe burns often experience a similar massive inflammatory response but without the underlying infectious toxins as many septic patients.  In addition, these patients often have an exact time of onset, often immediately prior to presentation, and receive immediate resuscitation as opposed to septic patients that may develop symptoms over hours to days prior to presentation and initiation of therapy.  Despite this early, aggressive therapy, burn patients experience AKI as often as sepsis patients.  In a study of 60 patients admitted with burns exceeding 20% body surface area, 53.3% developed AKI [24].  This reflects the upper range of AKI seen in the literature; however, the mortality for AKI in burn patients is somewhat lower than expected (7.6–34.4%) [22–24].Cardiac Arrest. Patients experiencing cardiac arrest often have prolonged periods of severe hypotension.  Of those that survive and achieve return of spontaneous circulation (ROSC), the need for vasoactive medications beyond 24 hours after ROSC correlates with the development of AKI, 51.7% versus 6.4%, likely reflecting overall systemic injury [120].Trauma. The incidence of AKI in trauma patients trends similarly to other populations, but the mortality did not reach levels seen in other studies.  This may reflect the younger patient populations seen by Gomes’ (mean age = 37) mortality rate of 8.2% [27] compared to Constantini’s (mean age = 42.3 with AKI and 52.9 without AKI) mortality rate of 10.8% [26] and Bagshaw’s (mean age = 62.5 with AKI and 47.3 without AKI) [17].Cardiothoracic and Vascular Surgery. Patients undergoing cardiac surgery face a unique combination of renal stressors from both major surgery as well as cardiopulmonary bypass.  Rates of AKI for elective cases generally range from 16.7% to 32.8% with a concomitant low mortality (1.3%–5.5%) with 2 exceptions [35, 36]. In 817 patients undergoing coronary artery bypass grafting while being on cardiopulmonary bypass, the incidence of AKI was 48.5% and mortality 12.6% [36].  Some of the decreased AKI and mortality rates may be explained by patient selection prior to undergoing surgery, but Roh et al. published a series of patients undergoing thoracic aortic graft placement of which 95% of the cases were performed emergently suggesting that patient selection alone may not be the sole factor [35]. The increased incidence of AKI and mortality noted by Lin et al. most likely reflects the prolonged duration of bypass since it was used primarily for the treatment of postcardiotomy cardiogenic shock well after completion of the surgical procedure [28]. Of note, vascular surgery in itself does not appear to be a major risk factor for AKI mortality [41].


## 10. Conclusions

AKI in the ICU has been difficult to study due to varying criteria for the definition of it prior to the adoption of the RIFLE and AKIN classifications.  There has been a gradual increase in incidence of AKI which may partly be explained by an increase in detection.  Furthermore, clinicians frequently underreport the incidence of AKI in sensitivity of the criteria to define AKI.  The overall incidence of AKI in the ICU is approximately 20%–50% and can have a mortality over 50%.  With the exception of liver transplant patients, surgical patients generally have a lower incidence of AKI, whereas patients with sepsis have the highest incidence.  Future studies may benefit by better identifying modifiable risk factors to prevent the development of AKI.



---

*Source: 479730-2013-03-21.xml*