# A Putative Case of Methotrexate-Related Lymphoma: Clinical Course and PET/CT Findings

Authors: Rachel C. Jankowitz; James Ganon; Todd Blodgett; Christine Garcia; Samuel Jacobs
Journal: Case Reports in Medicine
 (2009)

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## Abstract

Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX). We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX. The case is notable for the initial tumor burden, the dramatic disappearance of the PET-CT findings on discontinuation of MTX, and the subsequent early regrowth of disease. Our case report is illustrative of an MTX-related NHL in an autoimmune patient.Conclusion. Withdrawal of MTX in a patient with lymphoma is reasonable before initiating chemotherapy, but observation for early regrowth of disease is necessary.


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## Body


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*Source: 469343-2009-12-23.xml*