# Full N,N-Methylation of 4,4′-Methylenedianiline with Dimethyl Carbonate: A Feasible Access to 4,4′-Methylene bis(N,N-Dimethylaniline)

Authors: Zegang Qiu; Kunjie Wang; Zhiqin Li; Tao Li; Jinhao Bai; Chanjuan Yin; Xiushen Ye; Haining Liu
Journal: Journal of Chemistry
 (2018)

---

## Abstract

The full N,N-methylation of 4,4′-methylenedianiline (MDA) with dimethyl carbonate (DMC) was investigated. The yield of the major product 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) reached as high as 97% over NaY catalyst at 190°C for 6 h. The catalyst could be used for two more times with acceptable MBDMA yields higher than 90%. The main by-products were identified as three N-methylated derivatives. Surprisingly, the formation of the N-methoxycarbonylation product was extremely restrained, which could be produced in high yields of 98% on zinc acetate catalyst. Furthermore, the reaction pathway to the major product MBDMA was proposed. Finally, a feasible synthetic route of 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) was established, featuring a high yield, mild reaction conditions, and simple operations.


---

## Body

## 1. Introduction

The reaction of 4,4′-methylenedianiline (MDA) with dimethyl carbonate (DMC) produced 4,4′-methylenedimethyldiphenylcarbamate (MDC) in high yield of 98%, under the catalysis of the zinc acetate, as described in literatures [1, 2] and our previous work [3]. Furthermore, the results of our research demonstrated that the three main by-products formed during the N-methoxycarbonylation reaction were all N-methylated derivatives [3]. Such results revealed that the N-methoxycarbonylation and the N-methylation were two competitive processes in the reaction of MDA with DMC. So far, almost all of the research focused on the N-methoxycarbonylation process between MDA and DMC, which was always treated as the main reaction; accordingly, the details of N-methylation process were still left unknown. Thus, we moved our focus to the N-methylation reaction of MDA with DMC and tried to make it to be the predominant reaction. Two possible N-methylation reaction pathways were listed in Scheme 1. Our purpose was to produce 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) or 4,4′-methylene-bis-(N-methylaniline) (MBMA) or the both in high yield.Scheme 1
Two possible N-methylation reaction pathways of MDA with DMC.Aforementioned MBDMA has found many applications in many fields. For example, it can be used as an intermediate in dye manufacture and as an analytical reagent in the determination of lead, iodide, bromide, and so forth [4–6]. In addition, it can also form charge-transfer complex with phenazine and its derivatives [7–9]. Commercially, MBDMA was synthesized by condensation of N,N-dimethyl aniline with formaldehyde over homogeneous acid catalysts [10]. However, this route suffered from some problems such as process complexity, equipment corrosion, and environmental pollution caused by the waste produced. Recently, ionic liquid was used in the reaction of N,N-dimethylaniline with tetrachloromethane to produce MBDMA in the highest yield of 61% [11]. Also, the structure and vibrational spectra of MBDMA were investigated by the DFT-B3LYP and ab initio MP2 calculations [12].The reactant MDA has been produced on industrial scale, while DMC is a versatile methylating or methoxycarbonylating reagent for the green synthesis of many organics [13]. The N-methylation of primary amines with DMC has been extensively investigated [14–20]; in particular, a general protocol for the reductive N-methylation of primary and secondary amines using dimethyl carbonate and molecular hydrogen was developed recently [21]. It is worth noting that the mono-N-methylation of primary aromatic amines with dimethyl carbonate could occur in high selectivity [15, 16]. However, the N,N-methylation or mono-N-methylation of diamines with DMC has not been described. Therefore, works should be done to figure out how and to what extent the N,N-methylation or mono-N-methylation reaction of diamines with DMC occurs. Furthermore, a successful synthesis of MBDMA from MDA and DMC should not only set an example of the N,N-methylation reaction of diamine with DMC but also provide a new alternative route to MBDMA.In this paper, 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) was obtained by the N,N-methylation reaction of 4,4′-methylenedianiline (MDA) with dimethyl carbonate (DMC) in high yield, under the catalysis of NaY zeolite. Also, the main by-products formed during the N,N-methylation process were identified. The reusability of NaY catalyst was checked. Furthermore, the formation mechanism of the N-methylated compounds was discussed. However, the effort to produce MBMA failed, and the details will be provided later in this paper.


## 2. Experimental

### 2.1. Chemicals

4,4-Methylenedianiline (MDA) was commercially available and used without further treatment. DMC of analytically pure grade was purified by distillation before use. The Hβ, ZSM-5, NaY, NaX, and MCM-41 were commercial products from the Catalyst Plant of Nankai, and they were calcined at 500°C for 2 h before use.


### 2.2. Instrumentation

High performance liquid chromatography (HPLC) analyses were performed on a Shimadzu LC (Japan) equipped with a SPD-10Avp detector. A Shim-pack Vp-ODS column (150 × 4.6 mm) and a mobile phase CH3OH/H2O 60/40 (volume) were used. 1H NMR spectra were recorded on a Bruker drx-300 instrument (Germany). Chemical shifts were reported in ppm (δ-scale) relative to internal standard TMS; CDCl3 was used as a solvent. IR spectra (cm−1) were collected with a Thermo Nicolet 380 FT-IR (USA). X-ray diffraction (XRD) measurements were performed on a Bruker D8 Advance X-Ray Diffractometer (Germany) with a Cu Kα radiation source. Elemental analysis was performed with an Elementar Vario EL (Germany). HPLC coupled with mass spectrometry (HPLC/MS) was run on a Waters HPLC/MS system, equipped with a Waters alliance 2695 HPLC pump, a Waters 2996 photodiode array detector, and a Waters micromass ZQ-4000 mass spectrometer. A Waters symmetry C18 column (150 mm × 211 mm, 3 μm) and a mobile phase CH3OH/H2O 65/45 (volume) were used. The flow rate of the mobile phase was 3 mL/min. The ion source temperature was 130°C and the cone temperature was 20°C. N2 adsorption–desorption isotherms were recorded on a Tristar-3000 Micromeritics volumetric apparatus. The special surface area was calculated according to the BET isothermal equation. The temperature-programmed desorption of ammonia (NH3-TPD) was carried out. About 100 mg sample (20–40 mesh) was pretreated at 500°C for 2 h in a quartz tube in nitrogen stream. Then, it was cooled to 100°C and adsorbed ammonium for 10 min. The desorption of ammonium was conducted at a heating rate of 10°C/min in nitrogen flow (30 mL/min). The desorbed ammonium was monitored by a thermal conductivity detector (TCD).


### 2.3. Reaction

All the reactions were conducted in a 100 mL stainless autoclave with a magnetic stirrer. MDA, DMC, and catalysts were charged into the reactor. The air in the autoclave was fully replaced with nitrogen to guarantee that the reaction was carried out under the inert atmosphere. The mixture was then stirred constantly and heated to a selected temperature for certain hours. When the reaction was completed, the autoclave was cooled down to room temperature. The solid-liquid mixture obtained was separated into two parts by filtration: a white powder (zeolite catalyst) and a clear light yellow liquid. The liquid was then analyzed with Shimadzu HPLC using naphthalene as an internal standard. The conversion of MDA and the yield of MBDMA were calculated by HPLC.


### 2.4. Characterization of MBDMA

A MBDMA yield of 97% (2.47 g, 0.0097 mol) and a MDA conversion of 100% were attained, when a mixture of MDA (1.98 g, 0.01 mol), DMC (27.0 g, 0.30 mol), and NaY (1.98 g) was stirred at 190°C for 6 h. In this case, the liquid was a mixture consisting of MBDMA, DMC, and a tiny amount of by-products. After distilling off DMC from the mixture, a light yellow solid was obtained. The solid was further purified by recrystallization from alcohol, and a crystalline compound was obtained which was identified as MBDMA.Characterization data of MBDMA were listed as follows. 4,4′-Methylene bis(N,N-dimethylaniline) (MBDMA): IR (KBr)ν/cm−1 3448, 2886, 2804, 1613, 1564, 1521, 1480, 1444, 1355, 1342, 1309, 1231, 1189, 1168, 1124, 1071, 949, 829, 795, 568, 508; 1H NMR (300 MHz, CDCl3)δ 2.88 (s, 12H, CH3), 3.79 (s, 2H, CH2), 6.66–6.68 (m, 4H, Ar-H), 7.03–7.06 (m, 4H, Ar-H); MS,m/z, observed: 255.3 [M]+ + 1, C17H22N2 [M]+ + 1 requires: 255.4. For C17H22N2 (254.4); found: 79.94% C, 8.63% H, 10.73% N. requires: 80.27% C, 8.72% H, 11.01% N.


### 2.5. The Analysis of By-Products

In order to obtain a suitable amount of by-products for analyzing, a mixture of MDA (1.98 g, 0.01 mol), DMC (27.0 g, 0.30 mol), and NaY (1.98 g) was stirred at 150°C for 6 h, attaining a MBDMA yield of 11.4% and a MDA conversion of 100%. The liquid obtained after filtering off the catalyst was then analyzed with HPLC/MS.


## 2.1. Chemicals

4,4-Methylenedianiline (MDA) was commercially available and used without further treatment. DMC of analytically pure grade was purified by distillation before use. The Hβ, ZSM-5, NaY, NaX, and MCM-41 were commercial products from the Catalyst Plant of Nankai, and they were calcined at 500°C for 2 h before use.


## 2.2. Instrumentation

High performance liquid chromatography (HPLC) analyses were performed on a Shimadzu LC (Japan) equipped with a SPD-10Avp detector. A Shim-pack Vp-ODS column (150 × 4.6 mm) and a mobile phase CH3OH/H2O 60/40 (volume) were used. 1H NMR spectra were recorded on a Bruker drx-300 instrument (Germany). Chemical shifts were reported in ppm (δ-scale) relative to internal standard TMS; CDCl3 was used as a solvent. IR spectra (cm−1) were collected with a Thermo Nicolet 380 FT-IR (USA). X-ray diffraction (XRD) measurements were performed on a Bruker D8 Advance X-Ray Diffractometer (Germany) with a Cu Kα radiation source. Elemental analysis was performed with an Elementar Vario EL (Germany). HPLC coupled with mass spectrometry (HPLC/MS) was run on a Waters HPLC/MS system, equipped with a Waters alliance 2695 HPLC pump, a Waters 2996 photodiode array detector, and a Waters micromass ZQ-4000 mass spectrometer. A Waters symmetry C18 column (150 mm × 211 mm, 3 μm) and a mobile phase CH3OH/H2O 65/45 (volume) were used. The flow rate of the mobile phase was 3 mL/min. The ion source temperature was 130°C and the cone temperature was 20°C. N2 adsorption–desorption isotherms were recorded on a Tristar-3000 Micromeritics volumetric apparatus. The special surface area was calculated according to the BET isothermal equation. The temperature-programmed desorption of ammonia (NH3-TPD) was carried out. About 100 mg sample (20–40 mesh) was pretreated at 500°C for 2 h in a quartz tube in nitrogen stream. Then, it was cooled to 100°C and adsorbed ammonium for 10 min. The desorption of ammonium was conducted at a heating rate of 10°C/min in nitrogen flow (30 mL/min). The desorbed ammonium was monitored by a thermal conductivity detector (TCD).


## 2.3. Reaction

All the reactions were conducted in a 100 mL stainless autoclave with a magnetic stirrer. MDA, DMC, and catalysts were charged into the reactor. The air in the autoclave was fully replaced with nitrogen to guarantee that the reaction was carried out under the inert atmosphere. The mixture was then stirred constantly and heated to a selected temperature for certain hours. When the reaction was completed, the autoclave was cooled down to room temperature. The solid-liquid mixture obtained was separated into two parts by filtration: a white powder (zeolite catalyst) and a clear light yellow liquid. The liquid was then analyzed with Shimadzu HPLC using naphthalene as an internal standard. The conversion of MDA and the yield of MBDMA were calculated by HPLC.


## 2.4. Characterization of MBDMA

A MBDMA yield of 97% (2.47 g, 0.0097 mol) and a MDA conversion of 100% were attained, when a mixture of MDA (1.98 g, 0.01 mol), DMC (27.0 g, 0.30 mol), and NaY (1.98 g) was stirred at 190°C for 6 h. In this case, the liquid was a mixture consisting of MBDMA, DMC, and a tiny amount of by-products. After distilling off DMC from the mixture, a light yellow solid was obtained. The solid was further purified by recrystallization from alcohol, and a crystalline compound was obtained which was identified as MBDMA.Characterization data of MBDMA were listed as follows. 4,4′-Methylene bis(N,N-dimethylaniline) (MBDMA): IR (KBr)ν/cm−1 3448, 2886, 2804, 1613, 1564, 1521, 1480, 1444, 1355, 1342, 1309, 1231, 1189, 1168, 1124, 1071, 949, 829, 795, 568, 508; 1H NMR (300 MHz, CDCl3)δ 2.88 (s, 12H, CH3), 3.79 (s, 2H, CH2), 6.66–6.68 (m, 4H, Ar-H), 7.03–7.06 (m, 4H, Ar-H); MS,m/z, observed: 255.3 [M]+ + 1, C17H22N2 [M]+ + 1 requires: 255.4. For C17H22N2 (254.4); found: 79.94% C, 8.63% H, 10.73% N. requires: 80.27% C, 8.72% H, 11.01% N.


## 2.5. The Analysis of By-Products

In order to obtain a suitable amount of by-products for analyzing, a mixture of MDA (1.98 g, 0.01 mol), DMC (27.0 g, 0.30 mol), and NaY (1.98 g) was stirred at 150°C for 6 h, attaining a MBDMA yield of 11.4% and a MDA conversion of 100%. The liquid obtained after filtering off the catalyst was then analyzed with HPLC/MS.


## 3. Results and Discussion

### 3.1. Catalyst Function

As the zeolites exhibited effective catalytic activity to the methylation reaction of some aromatic amines [16, 17, 22–24], several different zeolites such as Hβ, H-ZSM-5, NaX, NaY, and MCM-41 were chosen to catalyze the reaction of MDA with DMC in order to obtain MBDMA, as shown in Table 1. Disparate catalytic performances were observed. Hβ and H-ZSM-5 exhibited almost no activity; MCM-41 facilitated the conversion of MDA but showed no selectivity to the MBDMA; NaX had better activity to the conversion of MDA but poor selectivity to MBDMA; NaY had the best activity and selectivity among the chosen zeolites. Under the catalysis of NaY, MDA could be completely transformed and MBDMA selectivity reached a high value of 91.1%. Such results revealed that the formation of MBDMA depended on the properties of the catalysts. The properties such as the pores and structures of Hβ, ZSM-5, NaX, NaY, and MCM-41 are apparently different. Hβ and H-ZSM-5 have micropores but have no cages, and NaX and NaY possessed micropores as well as octahedral zeolite cages, while MCM-41 possesses mesopores and orderly lined hexagonal channels. Therefore, it could be broadly inferred that the formation of MBDMA is associated with the pore sizes and structures. As NaY exhibited outstanding catalytic performance, further investigation was made to improve the yield of MBDMA and to clarify the reaction mechanism.Table 1
Formation of MBDMA over various catalysts.
Catalysts MDA MBDMA Conversion/% Selectivity/% Yield/% None 61.2 None None Hβ 61.8 None None ZSM-5 62.2 None None NaX 100 28.7 28.7 NaY 100 91.1 91.1 MCM-41 86.4 None None Reaction Conditions. DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), catalyst 1.98 g, reaction time 6 h, and reaction temperature 180°C.


### 3.2. The By-Products Formed over NaY

To help to comprehend the formation mechanism of the main product, the by-products in the reaction of MDA with DMC over NaY were analyzed by HPLC/MS, obtaining the liquid chromatogram (Figure1) and the MS spectra (Figure 2). Three by-products including1,2, and3 were detected as shown in Figure 1. The molecular weights of compounds1,2, and3 could be obtained by analyzing the MS spectra, which were listed in Table 2. The possible configurations of1,2, and3 could be sketched (shown in Table 2), based on the molecular weights and the known compounds (MDA and DMC) added in the reaction system. As we can see, compounds1 and3 only corresponded to1a and3a, respectively. Thus, the structures of compounds1 and3 were clearly identified (shown in Table 2), by combining the analyses of the fragment ions in the corresponding MS spectra. However, the molecular weights of compound2 corresponded to two possible configurations2a and2b. Therefore, meticulous analyses to MS spectra of2 in Figure 2(b) were done to further identify its structure. Fortunately, a key ion4 atm/z 106 (Figure 2(b)) was found, and it could be generated by2a but not by2b. Furthermore, most of the fragment ions in Figure 2(b) could be ascribed to compound2a. Thus, compound2 was confirmed to be2a. So far, the by-products1,2, and3 were finally identified as three N-methylated derivatives with different degrees of N-methylation, as shown in Table 2.Table 2
The molecular weights and structures of by-products1, 2, and 3.
Compound Molecular weights Identified structures Possible configurations 1 212 2 226 3 240Figure 1
The liquid chromatogram of the filtrate obtained after the reaction of MDA with DMC.Figure 2
MS spectra of the by-products1,2, and3. Subfigures (a), (b), and (c) present the MS spectra of the pseudomolecular ions of compounds1,2, and3, respectively.4 stands for the ion with anm/z value of 106.
(a) (b) (c)


### 3.3. The Optimum Reaction Conditions for the Formation of MBDMA

The effects of the reaction conditions including the reaction temperature, the reaction time, the NaY amount, and the DMC/MDA molar ratio on the formation of MBDMA over NaY zeolites were investigated, and the results were displayed in Table3 and Figures 3 and 4.Table 3
The effect of the reaction conditions on the formation of MBDMA over NaY zeolites.
Run Reaction temperature/°C Reactiontime/h m(NaY)/m(DMC) g/g n(DMC)/n(MDA)mol/mol MDA conversion/% MBDMA Yield/% Selectivity/% 1 120 6 0.07 30 61.2 0.0 0.0 2 150 6 0.07 30 96.5 22.7 23.5 3 160 6 0.07 30 100 39.2 39.2 4 170 6 0.07 30 100 56.5 56.5 5 180 6 0.07 30 100 91.1 91.1 6 190 6 0.07 30 100 97.4 97.4 7 200 6 0.07 30 100 97.5 97.5 8 190 0.2 0.07 30 96.1 13.2 13.7 9 190 0.5 0.07 30 100 26.6 26.6 10 190 2 0.07 30 100 65.1 65.1 11 190 4 0.07 30 100 94.2 94.2 12 190 6 0.07 30 100 97.4 97.4 13 190 7 0.07 30 100 97.4 97.4 14 190 6 0.01 30 100 67.1 67.1 15 190 6 0.03 30 100 96.2 96.2 16 190 6 0.05 30 100 96.8 96.8 17 190 6 0.07 30 100 97.4 97.4 18 190 6 0.09 30 100 97.5 97.5 19 190 6 0.07 15 100 87.6 87.6 20 190 6 0.07 20 100 96.2 96.2 21 190 6 0.07 25 100 96.5 96.5 22 190 6 0.07 30 100 97.4 97.4 23 190 6 0.07 35 100 97.4 97.4Figure 3
Liquid chromatograms obtained after the reaction between MDA and DMC under different temperatures. Reaction conditions: DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, and reaction time 6 h.m(NaY)/m(DMC) (g/g) = 0.07/1.Figure 4
Liquid chromatograms obtained after the reaction between MDA and DMC under different reaction times. Reaction conditions: DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, and reaction temperature 190°C.m(NaY)/m(DMC) (g/g) = 0.07/1.The NaY amount was expressed by NaY/DMC weight ratio. It was found that a ratio higher than 0.07 was needed to warrant the high MBDMA yields (Table3). In this reaction, DMC was taken in excess to fully utilize MDA and facilitate the product formation. DMC served as both the reagent and the solvent. The optimum DMC/MDA molar ratio was 30 (Table 3). The excess DMC distilling from the reaction mixture could be recycled.As shown in Table3, when the reaction temperature was 120°C, the conversion of MDA was at a low value of 61.2%, while the main product MBDMA was not detected. In this case, the converted MDA mainly produced by-products1 and2 (Figure 3). As the reaction temperature was increased, the conversion of MDA and the yield of MBDMA were accordingly increased. When the reaction temperature rose to 160°C, the conversion of MDA attained 100%; however, the selectivity of MBDMA was only 39.2%. Such poor MBDMA selectivity could be mostly attributed to the formation of the by-products2 and3 (Figure 3). When the reaction temperature was going on increased to 190°C, the selectivity of MBDMA reached to the highest value of 97.4%; on the contrary, the unwanted by-products were minimized to very small amount. Further increasing the reaction temperature to 200°C could not improve the selectivity of MBDMA anymore. Thus, the optimum reaction temperature should be controlled around 190°C. Furthermore, the yields of by-products1,2, and3 sequentially increased and then dropped one by one; such trend could effectively prove that the MBDMA was formed via the gradually N-methylated reaction.As we can see from Table3, when the reaction was carried out for 0.5 h, MDA had been fully converted; however, the MBDMA selectivity was at a low value of 26.6%; this was mainly because of the formation of by-products2 and3 (Figure 4). As the reaction time prolonged to 2 h, the MBDMA selectivity rose to 65.1%; in this case, the predominant by-product was3 (Figure 4). As the reaction time reached to 6 h, the highest MBDMA selectivity of 97.4% was achieved with a tiny amount of by-products formed. A longer reaction time could not improve the MBDMA selectivity anymore. So the optimum reaction time should be controlled around 6 h. The changing trend of the yields of by-products1,2, and3 over the reaction time was very similar to that over the reaction temperature. This further proved that the MBDMA was formed following the gradually N-methylated reaction route.


### 3.4. The Reusability of the Catalyst NaY

In order to check the reusability, the used NaY catalyst was filtered out, dried in the room temperature, and employed in the next run. The NaY catalyst was reused for two more times and the results are listed in Table4. As it is shown, the reused NaY catalysts gave excellent MDA conversion of 100% and MBDMA yield higher than 90%. However, MBDMA yield gradually decreased from 97% to 90% with the increase of the used times of NaY. To figure out the reason for such decrease, the reused NaY catalysts were characterized by XRD, IR, NH3-TPD, N2 adsorption, and elemental analysis.Table 4
Reuse of NaY zeolite catalyst.
Run MDA conversion (%) MBDMA yield (%) 1 100 97 2 100 94 3 100 90 Reaction  Conditions. DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, reaction time 6 h, and reaction temperature 190°C. m(NaY)/m(DMC) (g/g) = 0.07/1.Figure5 shows the XRD patterns of the fresh and reused NaY catalysts. All the samples similarly showed typical diffraction peaks of Y zeolite [25], indicating that the framework structures of the reused catalysts were essentially retained.Figure 5
XRD spectra of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.Figure6 displays the IR spectra. Clearly, all the samples exhibited similar peaks at the same wave numbers of about 470 cm−1, 1030 cm−1, 1100 cm−1, 1650 cm−1, and 3450 cm−1. The wave numbers of 470 cm−1, 1030 cm−1, 1100 cm−1, and 1650 cm−1 were assigned to the framework vibrations of Y zeolite [25, 26] and the 3450 cm−1 was assigned to the vibrations of the surface hydroxyl groups on Y zeolite [26]. The presence of those similar peaks further proved that the framework structures of the reused catalysts were essentially retained. However, the intensity of these peaks gradually attenuated with the reuse times of the NaY catalysts increasing, which was consistent with the decreasing trend of the MBDMA yield. The attenuation of the intensity of these IR peaks might be caused by the deposition of the compounds on the catalyst from the reaction mixture (see Table 5).Table 5
Elemental analysis and N2 adsorption of fresh and reused NaY catalysts.
Run C/wt% N/wt% Surface area/m2/g Pore volume/cm3/g 1 0.1 — 408.2 0.37 2 10.0 1.2 87.9 0.16 3 10.3 1.3 54.0 0.15Figure 6
IR spectra of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.Figure7 presents the NH3-TPD profiles. Generally, the desorption of NH3 at low temperature (<200°C) was related to weak acid sites, while those at medium (200°C–400°C) and high temperature (>400°C) were correlated with moderate and strong acid sites. The fresh NaY exhibited a peak of weak acid around 190°C, while the according peaks of reused NaY catalysts shifted to the low temperatures; in particular, the peak shift of the NaY catalysts reused for three times was rather obvious. Such shifts revealed that the acid strength of reused NaY was gradually weakened with the used times increasing. Apparently, this weakening trend of the acid strength of the NaY catalysts was consistent with the decreasing trend of the MBDMA yield. Thus, it is reasonable to infer that the weakening acid strength of the NaY was a factor leading to the decreasing of the MBDMA yield.Figure 7
NH3-TPD profiles of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.The elemental analysis results of fresh and reused NaY catalysts are listed in Table5. The content of the C in reused NaY catalysts sharply increased compared to that in the fresh catalysts, demonstrating the deposition of the compounds on the catalyst from the reaction mixture occurred. However, these depositing compounds cannot be detected by XRD and IR. Apparently, the deposition of the compounds would occupy some surfaces and pores, causing the decrease of the surface area and pore volume (Table 5). Accordingly, some effective active sites would be covered and the reaction place would somewhat shrink, consequently resulting in the decreasing of the MBDMA yield.Due to a comprehensive understanding of the results of XRD, IR, NH3-TPD, N2 adsorption, and elemental analysis, a full conversion of MDA was guaranteed by the essential retaining of the framework structures of the reused catalysts. The decrease of the MBDMA yield could be attributed to two factors: (1) the acid strength of reused NaY gradually weakened and (2) the deposition of the compounds from the reaction mixture covered some effective active sites and somewhat shrank the reaction space.


### 3.5. The Mechanism of N-Methylation Reaction of MDA with DMC

The N-methoxycarbonylation and the N-methylation were two competitive processes in the reaction of MDA with DMC. As described above, the full N-methylation of MDA with DMC occurred predominantly under the catalysis of NaY, while the N-methoxycarbonylation process was greatly restrained, obtaining a yield of the MBDMA as high as 97%. Such result presented a sharp contrast with the reaction of MDA with DMC catalyzed by zinc acetate [1–3], in which the N-methoxycarbonylation was the predominant process. Apparently, catalysts played a key role in the reaction of MDA with DMC. The zinc acetate effectively activated the carbonyl group of DMC and thus N-methoxycarbonylation product was easily formed by the direct attack of amino group of MDA on the carbonyl carbon of DMC [3, 27].However, the reaction of MDA with DMC on NaY was more complicated than that on zinc acetate. NaY can activate the molecule of DMC [20], which basically endowed it with enough activity to catalyze the reaction of MDA with DMC. However, this cannot guarantee a directional selectivity to a particular product, which was closely related to its particular pore structures.Generally, the N-methylation reactions of aromatic amines with DMC may follow two possible pathways [16, 18, 27]: (i) the amino group of aromatic amine directly attacks the methoxy group of DMC. (ii) The amino group of aromatic amine firstly attacks the carbonyl group of DMC, producing N-methoxycarbonylation intermediate. And then, the amino group of this intermediate further attacks the methyl of DMC, obtaining highly selective mono-N-methylated products. It should be noted that the selective mono-N-methylation reaction occurs in the octahedral zeolite cages of NaY in pathway (ii) [16, 18], making the particular pore structures of NaY to be a decisive factor in the selective synthesis of mono-N-methylated derivatives.As mentioned above, N-methylation process of MDA with DMC occurred gradually over the NaY catalyst, successively forming partially N-methylated products1,2, and3 before the final product MBDMA was formed. In contrast, the peak of MDC was not detected by HPLC. MDC was the N-methoxycarbonylated intermediate which had to be formed to selectively produce mono-N-methylated product of compound1 (MDMA), according to the pathway (ii) (shown in Scheme 2). Such results revealed that the N-methylation process of MDA with DMC obeyed the pathway (i), which is presented in Scheme 2. In this pathway (i), a high selectivity to the mono-N-methylated product of MDMA could not be achieved.Scheme 2
Two possible pathways of the N-methylation process of MDA with DMC in the presence of NaY.


## 3.1. Catalyst Function

As the zeolites exhibited effective catalytic activity to the methylation reaction of some aromatic amines [16, 17, 22–24], several different zeolites such as Hβ, H-ZSM-5, NaX, NaY, and MCM-41 were chosen to catalyze the reaction of MDA with DMC in order to obtain MBDMA, as shown in Table 1. Disparate catalytic performances were observed. Hβ and H-ZSM-5 exhibited almost no activity; MCM-41 facilitated the conversion of MDA but showed no selectivity to the MBDMA; NaX had better activity to the conversion of MDA but poor selectivity to MBDMA; NaY had the best activity and selectivity among the chosen zeolites. Under the catalysis of NaY, MDA could be completely transformed and MBDMA selectivity reached a high value of 91.1%. Such results revealed that the formation of MBDMA depended on the properties of the catalysts. The properties such as the pores and structures of Hβ, ZSM-5, NaX, NaY, and MCM-41 are apparently different. Hβ and H-ZSM-5 have micropores but have no cages, and NaX and NaY possessed micropores as well as octahedral zeolite cages, while MCM-41 possesses mesopores and orderly lined hexagonal channels. Therefore, it could be broadly inferred that the formation of MBDMA is associated with the pore sizes and structures. As NaY exhibited outstanding catalytic performance, further investigation was made to improve the yield of MBDMA and to clarify the reaction mechanism.Table 1
Formation of MBDMA over various catalysts.
Catalysts MDA MBDMA Conversion/% Selectivity/% Yield/% None 61.2 None None Hβ 61.8 None None ZSM-5 62.2 None None NaX 100 28.7 28.7 NaY 100 91.1 91.1 MCM-41 86.4 None None Reaction Conditions. DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), catalyst 1.98 g, reaction time 6 h, and reaction temperature 180°C.


## 3.2. The By-Products Formed over NaY

To help to comprehend the formation mechanism of the main product, the by-products in the reaction of MDA with DMC over NaY were analyzed by HPLC/MS, obtaining the liquid chromatogram (Figure1) and the MS spectra (Figure 2). Three by-products including1,2, and3 were detected as shown in Figure 1. The molecular weights of compounds1,2, and3 could be obtained by analyzing the MS spectra, which were listed in Table 2. The possible configurations of1,2, and3 could be sketched (shown in Table 2), based on the molecular weights and the known compounds (MDA and DMC) added in the reaction system. As we can see, compounds1 and3 only corresponded to1a and3a, respectively. Thus, the structures of compounds1 and3 were clearly identified (shown in Table 2), by combining the analyses of the fragment ions in the corresponding MS spectra. However, the molecular weights of compound2 corresponded to two possible configurations2a and2b. Therefore, meticulous analyses to MS spectra of2 in Figure 2(b) were done to further identify its structure. Fortunately, a key ion4 atm/z 106 (Figure 2(b)) was found, and it could be generated by2a but not by2b. Furthermore, most of the fragment ions in Figure 2(b) could be ascribed to compound2a. Thus, compound2 was confirmed to be2a. So far, the by-products1,2, and3 were finally identified as three N-methylated derivatives with different degrees of N-methylation, as shown in Table 2.Table 2
The molecular weights and structures of by-products1, 2, and 3.
Compound Molecular weights Identified structures Possible configurations 1 212 2 226 3 240Figure 1
The liquid chromatogram of the filtrate obtained after the reaction of MDA with DMC.Figure 2
MS spectra of the by-products1,2, and3. Subfigures (a), (b), and (c) present the MS spectra of the pseudomolecular ions of compounds1,2, and3, respectively.4 stands for the ion with anm/z value of 106.
(a) (b) (c)


## 3.3. The Optimum Reaction Conditions for the Formation of MBDMA

The effects of the reaction conditions including the reaction temperature, the reaction time, the NaY amount, and the DMC/MDA molar ratio on the formation of MBDMA over NaY zeolites were investigated, and the results were displayed in Table3 and Figures 3 and 4.Table 3
The effect of the reaction conditions on the formation of MBDMA over NaY zeolites.
Run Reaction temperature/°C Reactiontime/h m(NaY)/m(DMC) g/g n(DMC)/n(MDA)mol/mol MDA conversion/% MBDMA Yield/% Selectivity/% 1 120 6 0.07 30 61.2 0.0 0.0 2 150 6 0.07 30 96.5 22.7 23.5 3 160 6 0.07 30 100 39.2 39.2 4 170 6 0.07 30 100 56.5 56.5 5 180 6 0.07 30 100 91.1 91.1 6 190 6 0.07 30 100 97.4 97.4 7 200 6 0.07 30 100 97.5 97.5 8 190 0.2 0.07 30 96.1 13.2 13.7 9 190 0.5 0.07 30 100 26.6 26.6 10 190 2 0.07 30 100 65.1 65.1 11 190 4 0.07 30 100 94.2 94.2 12 190 6 0.07 30 100 97.4 97.4 13 190 7 0.07 30 100 97.4 97.4 14 190 6 0.01 30 100 67.1 67.1 15 190 6 0.03 30 100 96.2 96.2 16 190 6 0.05 30 100 96.8 96.8 17 190 6 0.07 30 100 97.4 97.4 18 190 6 0.09 30 100 97.5 97.5 19 190 6 0.07 15 100 87.6 87.6 20 190 6 0.07 20 100 96.2 96.2 21 190 6 0.07 25 100 96.5 96.5 22 190 6 0.07 30 100 97.4 97.4 23 190 6 0.07 35 100 97.4 97.4Figure 3
Liquid chromatograms obtained after the reaction between MDA and DMC under different temperatures. Reaction conditions: DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, and reaction time 6 h.m(NaY)/m(DMC) (g/g) = 0.07/1.Figure 4
Liquid chromatograms obtained after the reaction between MDA and DMC under different reaction times. Reaction conditions: DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, and reaction temperature 190°C.m(NaY)/m(DMC) (g/g) = 0.07/1.The NaY amount was expressed by NaY/DMC weight ratio. It was found that a ratio higher than 0.07 was needed to warrant the high MBDMA yields (Table3). In this reaction, DMC was taken in excess to fully utilize MDA and facilitate the product formation. DMC served as both the reagent and the solvent. The optimum DMC/MDA molar ratio was 30 (Table 3). The excess DMC distilling from the reaction mixture could be recycled.As shown in Table3, when the reaction temperature was 120°C, the conversion of MDA was at a low value of 61.2%, while the main product MBDMA was not detected. In this case, the converted MDA mainly produced by-products1 and2 (Figure 3). As the reaction temperature was increased, the conversion of MDA and the yield of MBDMA were accordingly increased. When the reaction temperature rose to 160°C, the conversion of MDA attained 100%; however, the selectivity of MBDMA was only 39.2%. Such poor MBDMA selectivity could be mostly attributed to the formation of the by-products2 and3 (Figure 3). When the reaction temperature was going on increased to 190°C, the selectivity of MBDMA reached to the highest value of 97.4%; on the contrary, the unwanted by-products were minimized to very small amount. Further increasing the reaction temperature to 200°C could not improve the selectivity of MBDMA anymore. Thus, the optimum reaction temperature should be controlled around 190°C. Furthermore, the yields of by-products1,2, and3 sequentially increased and then dropped one by one; such trend could effectively prove that the MBDMA was formed via the gradually N-methylated reaction.As we can see from Table3, when the reaction was carried out for 0.5 h, MDA had been fully converted; however, the MBDMA selectivity was at a low value of 26.6%; this was mainly because of the formation of by-products2 and3 (Figure 4). As the reaction time prolonged to 2 h, the MBDMA selectivity rose to 65.1%; in this case, the predominant by-product was3 (Figure 4). As the reaction time reached to 6 h, the highest MBDMA selectivity of 97.4% was achieved with a tiny amount of by-products formed. A longer reaction time could not improve the MBDMA selectivity anymore. So the optimum reaction time should be controlled around 6 h. The changing trend of the yields of by-products1,2, and3 over the reaction time was very similar to that over the reaction temperature. This further proved that the MBDMA was formed following the gradually N-methylated reaction route.


## 3.4. The Reusability of the Catalyst NaY

In order to check the reusability, the used NaY catalyst was filtered out, dried in the room temperature, and employed in the next run. The NaY catalyst was reused for two more times and the results are listed in Table4. As it is shown, the reused NaY catalysts gave excellent MDA conversion of 100% and MBDMA yield higher than 90%. However, MBDMA yield gradually decreased from 97% to 90% with the increase of the used times of NaY. To figure out the reason for such decrease, the reused NaY catalysts were characterized by XRD, IR, NH3-TPD, N2 adsorption, and elemental analysis.Table 4
Reuse of NaY zeolite catalyst.
Run MDA conversion (%) MBDMA yield (%) 1 100 97 2 100 94 3 100 90 Reaction  Conditions. DMC 27.0 g (0.30 mol), MDA 1.98 g (0.01 mol), NaY 1.98 g, reaction time 6 h, and reaction temperature 190°C. m(NaY)/m(DMC) (g/g) = 0.07/1.Figure5 shows the XRD patterns of the fresh and reused NaY catalysts. All the samples similarly showed typical diffraction peaks of Y zeolite [25], indicating that the framework structures of the reused catalysts were essentially retained.Figure 5
XRD spectra of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.Figure6 displays the IR spectra. Clearly, all the samples exhibited similar peaks at the same wave numbers of about 470 cm−1, 1030 cm−1, 1100 cm−1, 1650 cm−1, and 3450 cm−1. The wave numbers of 470 cm−1, 1030 cm−1, 1100 cm−1, and 1650 cm−1 were assigned to the framework vibrations of Y zeolite [25, 26] and the 3450 cm−1 was assigned to the vibrations of the surface hydroxyl groups on Y zeolite [26]. The presence of those similar peaks further proved that the framework structures of the reused catalysts were essentially retained. However, the intensity of these peaks gradually attenuated with the reuse times of the NaY catalysts increasing, which was consistent with the decreasing trend of the MBDMA yield. The attenuation of the intensity of these IR peaks might be caused by the deposition of the compounds on the catalyst from the reaction mixture (see Table 5).Table 5
Elemental analysis and N2 adsorption of fresh and reused NaY catalysts.
Run C/wt% N/wt% Surface area/m2/g Pore volume/cm3/g 1 0.1 — 408.2 0.37 2 10.0 1.2 87.9 0.16 3 10.3 1.3 54.0 0.15Figure 6
IR spectra of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.Figure7 presents the NH3-TPD profiles. Generally, the desorption of NH3 at low temperature (<200°C) was related to weak acid sites, while those at medium (200°C–400°C) and high temperature (>400°C) were correlated with moderate and strong acid sites. The fresh NaY exhibited a peak of weak acid around 190°C, while the according peaks of reused NaY catalysts shifted to the low temperatures; in particular, the peak shift of the NaY catalysts reused for three times was rather obvious. Such shifts revealed that the acid strength of reused NaY was gradually weakened with the used times increasing. Apparently, this weakening trend of the acid strength of the NaY catalysts was consistent with the decreasing trend of the MBDMA yield. Thus, it is reasonable to infer that the weakening acid strength of the NaY was a factor leading to the decreasing of the MBDMA yield.Figure 7
NH3-TPD profiles of fresh and reused NaY catalysts. (a) Fresh NaY; (b) NaY after used for the first time; (c) NaY after used for the second time.The elemental analysis results of fresh and reused NaY catalysts are listed in Table5. The content of the C in reused NaY catalysts sharply increased compared to that in the fresh catalysts, demonstrating the deposition of the compounds on the catalyst from the reaction mixture occurred. However, these depositing compounds cannot be detected by XRD and IR. Apparently, the deposition of the compounds would occupy some surfaces and pores, causing the decrease of the surface area and pore volume (Table 5). Accordingly, some effective active sites would be covered and the reaction place would somewhat shrink, consequently resulting in the decreasing of the MBDMA yield.Due to a comprehensive understanding of the results of XRD, IR, NH3-TPD, N2 adsorption, and elemental analysis, a full conversion of MDA was guaranteed by the essential retaining of the framework structures of the reused catalysts. The decrease of the MBDMA yield could be attributed to two factors: (1) the acid strength of reused NaY gradually weakened and (2) the deposition of the compounds from the reaction mixture covered some effective active sites and somewhat shrank the reaction space.


## 3.5. The Mechanism of N-Methylation Reaction of MDA with DMC

The N-methoxycarbonylation and the N-methylation were two competitive processes in the reaction of MDA with DMC. As described above, the full N-methylation of MDA with DMC occurred predominantly under the catalysis of NaY, while the N-methoxycarbonylation process was greatly restrained, obtaining a yield of the MBDMA as high as 97%. Such result presented a sharp contrast with the reaction of MDA with DMC catalyzed by zinc acetate [1–3], in which the N-methoxycarbonylation was the predominant process. Apparently, catalysts played a key role in the reaction of MDA with DMC. The zinc acetate effectively activated the carbonyl group of DMC and thus N-methoxycarbonylation product was easily formed by the direct attack of amino group of MDA on the carbonyl carbon of DMC [3, 27].However, the reaction of MDA with DMC on NaY was more complicated than that on zinc acetate. NaY can activate the molecule of DMC [20], which basically endowed it with enough activity to catalyze the reaction of MDA with DMC. However, this cannot guarantee a directional selectivity to a particular product, which was closely related to its particular pore structures.Generally, the N-methylation reactions of aromatic amines with DMC may follow two possible pathways [16, 18, 27]: (i) the amino group of aromatic amine directly attacks the methoxy group of DMC. (ii) The amino group of aromatic amine firstly attacks the carbonyl group of DMC, producing N-methoxycarbonylation intermediate. And then, the amino group of this intermediate further attacks the methyl of DMC, obtaining highly selective mono-N-methylated products. It should be noted that the selective mono-N-methylation reaction occurs in the octahedral zeolite cages of NaY in pathway (ii) [16, 18], making the particular pore structures of NaY to be a decisive factor in the selective synthesis of mono-N-methylated derivatives.As mentioned above, N-methylation process of MDA with DMC occurred gradually over the NaY catalyst, successively forming partially N-methylated products1,2, and3 before the final product MBDMA was formed. In contrast, the peak of MDC was not detected by HPLC. MDC was the N-methoxycarbonylated intermediate which had to be formed to selectively produce mono-N-methylated product of compound1 (MDMA), according to the pathway (ii) (shown in Scheme 2). Such results revealed that the N-methylation process of MDA with DMC obeyed the pathway (i), which is presented in Scheme 2. In this pathway (i), a high selectivity to the mono-N-methylated product of MDMA could not be achieved.Scheme 2
Two possible pathways of the N-methylation process of MDA with DMC in the presence of NaY.


## 4. Conclusion

In this work, an access to 4,4′-methylene bis(N,N-dimethylaniline) (MBDMA) via N,N-methylation of 4,4′-methylenedianiline (MDA) with dimethyl carbonate (DMC) over NaY catalyst was reported. This process features a high yield of the required product under mild reaction conditions and sets an example of the N,N-methylation reaction of diamine with DMC. The reusability of the catalyst and the simple operations are also the advantages of this method. Also, a reasonable reaction pathway was proposed based on the identification of the by-products and the tracing analysis of the transformation of the by-products during the reaction process. Furthermore, the implementation of such process proved that the selectivity to the two competitive processes N-methylation and N-methoxycarbonylation can be controlled by changing the catalysis systems and the reaction conditions.



---

*Source: 4627903-2018-04-18.xml*