# Amyloidoma, an Unusual Cause of Fracture

Authors: Frank Verhoeven; Clément Prati; Daniel Wendling
Journal: Case Reports in Rheumatology
 (2014)

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## Abstract

We report a case of a spontaneous hip fracture in a context of dysglobulinemia. The bone histologic examination found amyloidoma. Amyloidoma is an overload pathology and an unusual cause of fracture. In most of the cases, it is associated with myeloma and the difference between bone invasion of myeloma and amyloidoma in an osteolytic radiographic picture is not easy but is of importance because prognosis and treatment may be totally different. Thus, in the context of dysglobulinemia, one must keep in mind that spontaneous bone fracture may be due to amyloidoma with another prognosis.


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## Body

## 1. Introduction

Amyloidoma is an uncommon cause of bone fragility. It occurs in the context of dysglobulinemia and the difference between amyloidoma and myeloma is difficult but is important.


## 2. Case

We report the clinical story of an 87-year-old man who was hospitalized for a right hip fracture without high energy trauma. He was known, but not followed up, for a kappa light chain monoclonal gammopathy diagnosed 7 years ago. He had no inflammatory syndrome (CRP< 10 mg/dL and ESR < 25 mm) and no hypercalcemia (<2, 57 mmol/L). The electrophoresis was characterized by an hypogammaglobulinemia and the presence of kappa light chain. The myelogram showed 9% of kappa light chain monoclonal plasmocytes. The Bence Jones proteinuria was positive. He underwent a hip arthroplasty and the histological examination of the femoral head found multifocal non-AA amyloid deposits, with osteolysis and a pseudotumoral aspect (amyloidoma). A biopsy of accessory salivary glands found non-AA amyloid deposits too. The radiographic exam (Figure 1) at the time of the fracture diagnosis showed geodes surrounded by area of osteosclerosis corresponding to focal deposits of amyloid. The extension statement showed only other geodes in the left hip (Figure 2). Six months later, he suffered from a contralateral hip fracture probably secondary to amyloidosis too.Figure 1
Radiographic aspect of hip fracture Garden 3 secondary to amyloidoma.Figure 2
Geode of the left hip probably secondary to amyloidoma.


## 3. Discussion

This is the second observation of hip fracture secondary to amyloidoma [1]. Amyloidoma is an unusual cause of fracture. Amyloidosis is an overload pathology characterized by extra cellular deposits of amyloid substance. The osteoarticular involvement represented by amyloidoma, amyloid arthropathy [2], and amyloid polyarthritis [3] is rare. Few types of amyloidosis are responsible for these manifestations [4]: AL amyloidosis which is primary or associated with myeloma [5], β 2-microglobulin amyloidosis which is associated with chronic dialysis [6], and ATTR amyloidosis including the senile and the hereditary amyloidosis.Amyloidoma is most frequently associated with the AL amyloidosis which is linked with myeloma by the kappa or lambda light chain. These light chains share the same amino acid sequence with the AL amyloid substance [4]. Among these associations, amyloidoma can be a primary pathology, but it is less frequent. In the literature, 35 cases of bone locations (Table 1) are described to date and mainly in the spine. There are 23 vertebral involvements, and 6 are located at the skull. Peripheral involvements are more exceptional. There are just two humeral locations and one femoral [1] location described and finally 3 locations in the belts. This distribution is the same as for myeloma, in the trabecular bone. These locations might be explained by the possible immunoglobulin origin of amyloid proteins and the similarity of the amino acid sequence. The difference between bone invasion of myeloma and amyloidoma in front of an osteolytic lesion is not clear in a patient suffering from myeloma. In case of amyloidoma, we can observe a geode surrounded by osteosclerosis and this osteosclerosis may differentiate between the two conditions. This detail may be interesting in the absence of histologic data. This is important since the treatment and the prognosis are totally different between myeloma lesions and amyloidoma.Table 1
Bone locations of amyloidoma.
Authors
Locations
Context
Factor RE et al.; Diagn Cytopathol. (2012)
Iliac bone
Myeloma
Farrell K et al.; J Clin Oncol. (2011)
Cervical spine
Myeloma
Parmar H et al.; AJNR Am J Neuroradiol. (2010)
1 skull 1 lumbar spine 1 thoracic spine 1 iliac bone
Primary
Oruckaptan H et al.; Turk Neurosurg. (2009)
Skull and cervical spine
Dialysis
Abbas N et al.; Br J Neurosurg. (2008)
Thoracic spine
Primary
Iplikcioglu AC et al.; Spine. (2007)
Cervical spine
Primary
Volkan Aydin M et al.; J Spinal Disord Tech. (2006)
Thoracic spine
Primary
Iguchi T et al.; Rinsho Ketsueki. (2005)
Humerus
Dysglobulinemia
Mulleman D et al.; Eur Spine J. (2004)
Cervical spine
Primary (evolution to systemic amyloidosis)
Manucha V et al.; Diagn Cytopathol. (2003)
Thoracic spine
Primary
Rachbauer F et al.; AJR Am J Roentgenol. (2003)
Clavicle
Dysglobulinemia
Unal A et al.; Clin Neurol Neurosurg. (2003)
Thoracic spine
Primary
Bruninx G et al.; J Radiol. (2001)
Sacrum
Primary
Hsu CW et al.; Ren Fail. (2001)
Cervical spine
Dialysis
Simoens WA et al.; AJNR Am J Neuroradiol. (2000)
Skull
Primary
Hwang SS et al.; AJNR Am J Neuroradiol. (2000)
Cervical spine
Primary
Miossec P et al.; Diabetes Metab. (1999)
Lumbar spine
Primary
Sancho JM et al.; Med Clin (Barc). (1999)
Lumbar spine
Primary
Mathew JM et al.; Br J Neurosurg. (1998)
Thoracic spine
Primary
Dee CH et al.; Spine. (1998)
Thoracic spine
Primary
Porchet F et al.; Spine. (1998)
Cervical spine
Primary
Pambuccian SE et al.; Am J Surg Pathol. (1997)
1 cervical spine1 scapula1 humeral head
Dysglobulinemia andlymphoplasmacytic infiltrate
Hidalgo F et al.; Neuroradiology. (1996)
Skull
—
Cloft HJ et al.; AJNR Am J Neuroradiol. (1995)
Thoracic spine
Primary
Chang YS et al.; Zhonghua Yi Xue Za Zhi (Taipei). (1993)
Thoracic and lumbar spine
Primary
Unal F et al.; J Neurosurg. (1992)
Skull
Primary
Dickman CA et al.; Neurosurgery. (1988)
Cervical spine
—
Leeson MC et al.; Spine. (1985)
Thoracic spine
Primary
Lai KN et al.; Am J Med. (1984)
Femoral neck
Myeloma
Giordano A et al.; Otolaryngol Head Neck Surg. (1983)
Skull
—
FADELL EJ et al.; Am J Surg. (1964)
Sternum
—Thus, in case of fracture in a patient with dysglobulinemia, one must keep in mind the possibility of an amyloidoma, especially in front of a geode surrounded by osteosclerosis.



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*Source: 424056-2014-03-16.xml*