# Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors

Authors: Stéphane L. Raeppel; Frédéric Gaudette; Hannah Nguyen; Normand Beaulieu; James Wang; Christiane Maroun; Jeffrey M. Besterman; Arkadii Vaisburg
Journal: International Journal of Medicinal Chemistry
 (2012)

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## Abstract

A novel series ofN-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified. SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low nanomolar range with low residual activity against c-Met and with no significant activity against VEGFR2.


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## Body


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*Source: 412614-2012-05-02.xml*