# Bilateral One-Stage Revision of Infected Total Hip Arthroplasties: Report of Two Cases and Management of Antibiotic Therapy

Authors: Thomas Pommepuy; Adrien Lons; Kevin Benad; Eric Beltrand; Eric Senneville; Henri Migaud
Journal: Case Reports in Orthopedics
 (2016)

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## Abstract

Recommendations for the management of chronic and bilateral total hip arthroplasty (THA) infection are lacking. However, this type of infection involves medical problems concerning the management of the antibiotic therapy. We report two cases of such infections operated as one-stage revision. For each case, both hips were infected with the same bacteria (Staphylococcus caprae for one patient and methicillin-sensitiveStaphylococcus aureus for the other). The probabilistic antibiotic treatment started during the first side (after harvesting intraoperative samples) did not prevent the culture of the bacteriologic harvested during the intervention of the second side. Cultures were positive for the same bacteria for both sides in the two cases presented herein. After results of intraoperative cultures, patients received culture-guided antibiotic therapy for three months and were considered cured at the end of a two-year follow-up. Our results suggest one-stage bilateral change of infected THA is a viable option and that early intraoperative antibiotic, started during the first-side exchange, does not jeopardize microbiological documentation of the second side. This work brings indirect arguments, in favor of the use of prophylactic antibiotics during revision of infected THA.


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## Body

## 1. Introduction

Total hip arthroplasty (THA) infections occur in 0.5 to 3% of patients, and may account for a third of reoperations and require multidisciplinary management [1–3]. Bilateral infections remain sporadic without clear recommendations. The large study from the Société Française d’Orthopédie-Traumatologie (SOFCOT) reported only 3 bilateral out of 691 THA infections and recommended a two-stage strategy, but no guideline was given for the antibiotic therapy in such situations [4]. This issue was not addressed in the document of the recent International Consensus Meeting on Prosthetic Joint Infections (ICMPJI) [5]. It is largely admitted that a microbiological documentation is essential to manage such chronic infections [3–5]. Choosing a one-stage approach with bilateral replacement in the same session requires intraoperative administration of antibiotics before correcting the second side which may lead to false negative bacterial cultures on the second side. [3–6]. Facing two cases of bilateral infection we made the choice of one-stage strategy and we started probabilistic antibiotics intraoperatively for the first side before the change of the second side. We found it interesting to study these two cases to evaluate the influence of antibiotics on the culture of intraoperative samples and so to argument for prophylactic antibiotics during revision of infected THA.


## 2. Observation

The first case was a sixty-year-old male, with an American Society of Anesthesiology (ASA) score of 2 and history of bilateral arthroplasty in 2009 and 2010 done at another institution. He was refereed to our center in 2011 for bilateral hip pain and was suspected of presenting chronic infection, because of radiological signs of intense femoral periosteal reaction (Figure1(a)). Joint aspiration confirmed the diagnosis, identifyingStaphylococcus caprae in both hips. The patient underwent a bilateral change in one stage with the administration of broad-spectrum empiric antibiotic therapy as soon as surgical samples were taken on the first side. Replacement of the second side was conducted with the same protocol. Microbiological cultures of both hips were positive with the same bacteria (Staphylococcus caprae sensitive to methicillin) found on four samples out of six, on standard and Rosenow’s growth medium enriched cultures [7] (Table 1).Table 1
Demographic, microbiological, and therapeutic data.
Case  1
Case  2
Left hip
Right hip
Left hip
Right hip
Date of index surgery
2009
2010
2006
2009
Indication for THA
Primary osteoarthritis
ASA score
2
2
CRP level at diagnosis (N
<
5 mg/L)
18 mg/L
81 mg/L
White blood cells count (N
=
4000–10000/mm3)
11700/mm3
12500/mm3
Neutrophil polynuclear cells count (N
=
2000–8000/mm3)
9360/mm3
9850/mm3
Date of joint aspiration
02/11/2011
02/11/2011
02/07/2012
14/07/2012
Bacteria at culture
⁢Staphylococcus caprae sensitive to ⁢methicillin (coagulase negative)
⁢Methicillin-sensitive
Staphylococcus aureus (MSSA)
Date of 1-stage bilateral revision
21/11/2011
06/08/2012
Delay from probabilistic ATB to sample collection in the second hip
180 minutes
180 minutes
Probabilistic ATB
Cefepime + daptomycin
Cefotaxime + vancomycin
Culture-guided ATB debuted  intravenously on  day 5 for 5 days and then switched to oral for 10 weeks
Rifampicin + levofloxacin
Rifampicin + levofloxacin
Positivity of culture samples on the second side
⁢Same bacteria4 out of 6 samples (3 Rosenow’s broth and 1 standard)
⁢Same bacteria4 out of 6 samples  (2 Rosenow’s broth and 2 standard)
CRP at the time of withdrawal of antibiotic therapy (N
<
5 mg/L)
5 mg/L
3 mg/L
Intraoperative bleeding
1200 cc
1600 cc
Posttreatment follow-up duration
36 months
24 months
ATB: antibiotics therapy; CRP: C-reactive protein.Figure 1
(a) Preoperative AP view case 1 showing typical features of intense femoral periosteal reaction suggesting pain was related to infection. (b) Case  1 AP view at 3 years of follow-up showing regression of periosteal reaction.
(a)
(b)The second case was a sixty-year-old female, with an ASA score of 2 and history of bilateral arthroplasty in 2006 and 2009, who consulted in 2012 for left hip pain associated with systemic inflammatory reaction (Table1). Microbiological cultures of the left hip liquid aspiration were positive with methicillin-sensitiveStaphylococcus aureus (MSSA). Three weeks later, right hip pain occurred that justified a joint aspiration from the hip in which the same MSSA strain according to the antibiotype was identified. The patient underwent bilateral hip change in one stage according to same surgical and antibiotic therapy protocols as the first case. Cultures of the two hips were positive with the same bacteria (MSSA) on four samples out of six, on standard and Rosenow’s growth medium enriched cultures [7].The pathogens identified during hip aspiration were sensitive to the probabilistic antibiotics. Both cases received the same antibiotic treatment adapted to their antibiograms (rifampicin + levofloxacin) introduced on day 5 for five days intravenously and then for three months per os regimen. At the end of a three-year (case one) and two-year (case two) follow-up, the functional Oxford score [8] was, respectively, 12/60 and 18/60, their CRP was normal, and periosteal reaction had dropped for case one (Figure 1(b)).


## 3. Discussion

Both cases suggest that it seems possible, with a satisfactory microbiological documentation and therefore culture-guided appropriate antibiotic therapy, to perform bilateral one-stage replacement of infected THA. Former studies were in favor of a two-stage revision to manage bilateral infected hip arthroplasties [4], but repeated surgery and an incapacity period due to two-stage replacement led us to prefer the option of one-stage surgery [3, 5, 6].In the two cases presented above, there are some practical problems. Firstly, the one-stage revision option implies potential surgical risks. However, our patients had low morbidity with an ASA score of 2 and our surgery protocol was strict (change of all prosthesis components and intensive debridement of the surgical site). One-stage strategy allows sterilizing all septic sites and reduces cost (a single hospitalization and antibiotics therapy, a shorter nonworking period) and faster rehabilitation. Secondly, we believe there is a risk of contamination of the nonreplaced side, when the replacement is unilateral. Thirdly, the probabilistic antibiotic therapy could have resulted in false negative culture of the second hip, though it was not reported in our cases. The two cases of the present study advocate the use of antibiotic prophylaxis in case of THA revision for infection [6, 9]. It is however difficult to definitely conclude on this last point as the microbiological documentation is of paramount importance in the management of prosthetic joint infections [5, 6, 9].



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