# Clinical Efficacy of Single-Port Thoracoscopic Lobectomy versus Three-Port Thoracoscopic Lobectomy for Lung Cancer

Authors: Yueliang Xu; Yinxi Zhou; Feng Lv; Yongshi Liu; Xiang Ji
Journal: Journal of Oncology
 (2022)

---

## Abstract

Objective. To evaluate the clinical efficacy of single-port thoracoscopic lobectomy versus three-port thoracoscopic lobectomy for lung cancer. Methods. From February 2020 to February 2021, 200 lung cancer patients treated in our institution assessed for eligibility were enrolled and randomly assigned (1 : 1) to either the experimental group (single-port thoracoscopic lobectomy) or the control group (three-port thoracoscopic lobectomy). The outcomes were the eligible patients’ surgical indices, pain stress indexes, and postoperative complications. Results. The experimental group outperformed the control group in terms of incision length, postoperative drainage time, extubation time, time to get out of bed, time to analgesics administration, and postoperative pain score (P<0.001). Compared with the control group, the experimental group reduced the intraoperative bleeding (161.98±10.65 versus 179.65±14.20, P<0.001) and length of hospital stay (7.98±0.56 versus 10.46±1.23, P<0.001). The operative time of the single-port thoracoscopic lobectomy was longer than that of the three-port thoracoscopic lobectomy (P<0.001). There was no statistical difference between the two groups in the intraoperative conversion to thoracotomy and the number of lymph node dissections (P>0.05). Postoperative pain stress indices and complication rates of the experimental group were significantly lower than those of the control group (P<0.001). Conclusion. Single-port thoracoscopic lobectomy can improve the perioperative indices of lung cancer patients, reduce their pain stress response, and accelerate postoperative recovery. However, its operation is difficult and time-consuming, requiring experienced surgeons for improved surgical outcomes in practice.


---

## Body

## 1. Introduction

Lung cancer is a malignant tumor originating from the mucosa or glands of the trachea and bronchi. Statistics in China in 2015 showed that the incidence of this disease ranked first and second among malignant tumors in male and female residents, respectively, and the mortality rate ranked first [1, 2]. Patients are universally associated with a poor prognosis, with a 5-year survival rate of less than 20.0% [3], necessitating early diagnosis and treatment. At present, surgery is the choice of treatment for lung cancer, and it applies to all early lung cancers as well as a few advanced-stage nonsmall cell lung cancers, with a 5-year survival rate of 44.0% and a surgical mortality rate of only 1.0%-2.0% [4, 5]. The established surgical procedure is open thoracotomy for lung cancer, but the damage to the healthy tissues adjacent to the lesion due to the large surgical incision, and even the collateral to the intercostal nerve, may seriously undermine the postoperative recovery [6]. In recent years, with the development of minimally invasive medical technology, thoracoscopic surgery has been increasingly used in clinical practice. Video-assisted thoracoscopic lobectomy features significant advantages such as minimally invasive and mild pain, which can effectively shorten the hospital stay of patients [7] and reduce the incidence of postoperative complications. The National Comprehensive Cancer Network guidelines (NCCN) recommended thoracoscopic lobectomy as the standard surgical approach for the treatment of lung cancer in 2006 in light of its remarkable efficacy [8], and in the previous decade, different branches of the technique were developed from the previous four-port and three-port surgical approaches to the two-port and single-port ones. Currently, the three-port approach is the conventional choice for thoracoscopic radical pneumonectomy [9], but the continuous optimization of medical technology has also confirmed the effectiveness of the single-port approach. Prior literature has partially compared the therapeutic efficacy of the three-port approach with the single-port approach [10], albeit evidence was untenable given the small sample size and unidentified mechanism. Accordingly, this study was to investigate the clinical efficacy of conventional three-port thoracoscopic lobectomy versus single-port thoracoscopic lobectomy for the treatment of lung cancer by examining the impact of different approaches on patients’ perioperative indices.


## 2. Materials and Methods

### 2.1. Study Design

This retrospective study was conducted in our hospital from February 2020 to February 2021 to investigate the clinical efficacy of three-port thoracoscopic lobectomy versus single-port thoracoscopic lobectomy for lung cancer.


### 2.2. Inclusion and Exclusion Criteria

Inclusion criteria are as follows: (1) Patients were diagnosed with lung cancer by routine chest CT examination and preoperative biopsy and met the diagnostic criteria in the Chinese guidelines for the treatment of primary lung cancer [11]; (2) patients’ lesions were localized to one lobe with a diameter of ≤5 cm; (3) patients were treated in our hospital throughout the whole process without hospital referral; (4) patients without any abnormal function of important organs; and (5) patients with no contraindications to radical lung cancer surgery and no involvement of the tumor in the chest wall and could tolerate thoracoscopic surgery.Exclusion criteria are as follows: (1) distant metastasis was found by abdominal ultrasound, bone scan, and cranial MRI; (2) patients with abnormal function of important organs such as heart, liver, and kidney; (3) patients with other malignant tumors; (4) patients with hematological, neurological, and immune system diseases; (5) patients with the tumors involved in the chest wall, large blood vessels, or invasion of the main bronchial opening, which prevented thoracoscopic surgery; and (6) patients who had received radiotherapy before surgery.


### 2.3. Baseline Data

200 lung cancer patients treated in our institution assessed for eligibility were enrolled and randomly assigned (1 : 1) to either the experimental group (n=100) or the control group (n=100). Patients’ characteristics and medical histories were recorded by personal interviews with trained doctors and nurses. BMI was calculated as weight divided by height squared (kg/m2). After surgery, patients’ pathological type, tumor site, and tumor size were recorded. The two groups of eligible patients showed similar clinical baseline features (P>0.05) (Table 1).Table 1
Comparison of baseline data.
GroupsExperimental group (n=100)Control group (n=100)X2/tPGender0.3280.567Male5660Female4440Age (year)Range41-7442-74Mean age56.65±5.9856.70±5.770.0600.952Mean weight (kg)58.65±2.6558.71±2.470.1660.869BMI (kg/m2)22.11±1.6522.14±1.530.1330.894Tumor stageIa24260.1670.744Ib36340.0880.767IIa20200.0001.000IIb16140.1600.689IIIa460.4210.516Pathological typeSquamous carcinoma44480.3220.570Adenocarcinoma48401.2990.254Other8120.8890.346Tumor siteUpper left lobe30320.0940.760Lower left lobe20180.1300.718Upper right lobe20200.0001.000Lower right lobe22240.1130.737Right middle lobe860.3070.579Tumor size (cm)3.21 ± 0.213.24 ± 0.230.9630.337


### 2.4. Ethical Considerations

All patients signed the informed consents, and the study was approved by the medical ethnic review board. The present study was conducted as per the principles of the Declaration of Helsinki (2013) [12].


### 2.5. Methods

Both groups underwent lobectomy + lymph node dissection, with single-port thoracoscopic lobectomy in the experimental group and three-port thoracoscopic lobectomy in the control group.In the experimental group, with the patient in the lateral position, double-lumen endotracheal tube placement was performed, followed by intravenous anesthesia and epidural anesthesia, and one-lung ventilation was given. A 3-cm incision was made between the 4th and 5th ribs in the anterior axillary line, followed by placement of a wound protection sleeve, where all surgical instruments were entered through this port. A 5-mm 30° lens was used to observe the thoracic cavity for the presence of adhesions and lobar fissures and lobulation. All operations were performed under the thoracoscope using long lumpectomy instruments, and the pulmonary arteries, bronchi, and interlobular fissures were treated with imported disposable cutting sutures. The patients underwent standard lung and mediastinal lymph node dissection, including intrapulmonary lymph nodes R2-4, 7, and 10 on the right side and L5, 7, and 10 on the left side. Routine postoperative paroxysms were given, and a chest drain was placed in this operation port.For the control group, a 1.5-cm incision was made in the 7th-8th intercostal space in the mid-axillary line, and a trocar was placed as the observation port. A 3-cm incision was then made in the 3rd or 4th intercostal space in the anterior axillary line, and a wound protection sleeve was placed as the main operation port, followed by a 1.5-cm incision made in the 5th or 6th intercostal space in the posterior axillary line as the secondary operation port. The surgical instruments, materials used, and lymph node dissection were the same as those in the experimental group.


### 2.6. Outcome

The outcomes are as follows:(1)
Baseline data: gender, weight, BMI, tumor stage, pathological type, tumor sites, and tumor size of patients(2)
Surgical indices: the surgical indices include operative time, incision length, intraoperative bleeding, intraoperative conversion to thoracotomy, number of lymph nodes dissection, postoperative drainage time, extubation time, length of hospital stay, and pain scores at different time points. The pain score was scaled per the postoperative numerical rating scale (NRS) [13], and the comparison of pain scores was carried out at 1 d, 3 d, and 7 d postoperatively. The NRS is a 10-point sliding scale with the number 1 to 10 for patients to describe their pain by circling out the number matching their conditions. The lower the score, the milder the pain(3)
Pain stress indices: 3 ml of morning fasting venous blood was collected from the eligible patients before and 7 d after surgery, and the levels of prostaglandin (PGE2), substance P (SP), and bradykinin (BK) were determined using a fully automated luminescence immunoassay analyzer (Roche Diagnostics GmbH, National Instrument Injection 20172222266)(4)
Incidence of postoperative complications: the postoperative complications of patients in both groups were recorded to calculate the incidence of complications in both groups


### 2.7. Statistical Analysis

SPSS 20.0 was used for data analyses, and GraphPad Prism 7 (GraphPad Software, San Diego, USA) was for image rendering. The count data were analyzed by the chi-square test, and the measurement data were analyzed by thet-test. Differences were considered statistically significant at P<0.05.


## 2.1. Study Design

This retrospective study was conducted in our hospital from February 2020 to February 2021 to investigate the clinical efficacy of three-port thoracoscopic lobectomy versus single-port thoracoscopic lobectomy for lung cancer.


## 2.2. Inclusion and Exclusion Criteria

Inclusion criteria are as follows: (1) Patients were diagnosed with lung cancer by routine chest CT examination and preoperative biopsy and met the diagnostic criteria in the Chinese guidelines for the treatment of primary lung cancer [11]; (2) patients’ lesions were localized to one lobe with a diameter of ≤5 cm; (3) patients were treated in our hospital throughout the whole process without hospital referral; (4) patients without any abnormal function of important organs; and (5) patients with no contraindications to radical lung cancer surgery and no involvement of the tumor in the chest wall and could tolerate thoracoscopic surgery.Exclusion criteria are as follows: (1) distant metastasis was found by abdominal ultrasound, bone scan, and cranial MRI; (2) patients with abnormal function of important organs such as heart, liver, and kidney; (3) patients with other malignant tumors; (4) patients with hematological, neurological, and immune system diseases; (5) patients with the tumors involved in the chest wall, large blood vessels, or invasion of the main bronchial opening, which prevented thoracoscopic surgery; and (6) patients who had received radiotherapy before surgery.


## 2.3. Baseline Data

200 lung cancer patients treated in our institution assessed for eligibility were enrolled and randomly assigned (1 : 1) to either the experimental group (n=100) or the control group (n=100). Patients’ characteristics and medical histories were recorded by personal interviews with trained doctors and nurses. BMI was calculated as weight divided by height squared (kg/m2). After surgery, patients’ pathological type, tumor site, and tumor size were recorded. The two groups of eligible patients showed similar clinical baseline features (P>0.05) (Table 1).Table 1
Comparison of baseline data.
GroupsExperimental group (n=100)Control group (n=100)X2/tPGender0.3280.567Male5660Female4440Age (year)Range41-7442-74Mean age56.65±5.9856.70±5.770.0600.952Mean weight (kg)58.65±2.6558.71±2.470.1660.869BMI (kg/m2)22.11±1.6522.14±1.530.1330.894Tumor stageIa24260.1670.744Ib36340.0880.767IIa20200.0001.000IIb16140.1600.689IIIa460.4210.516Pathological typeSquamous carcinoma44480.3220.570Adenocarcinoma48401.2990.254Other8120.8890.346Tumor siteUpper left lobe30320.0940.760Lower left lobe20180.1300.718Upper right lobe20200.0001.000Lower right lobe22240.1130.737Right middle lobe860.3070.579Tumor size (cm)3.21 ± 0.213.24 ± 0.230.9630.337


## 2.4. Ethical Considerations

All patients signed the informed consents, and the study was approved by the medical ethnic review board. The present study was conducted as per the principles of the Declaration of Helsinki (2013) [12].


## 2.5. Methods

Both groups underwent lobectomy + lymph node dissection, with single-port thoracoscopic lobectomy in the experimental group and three-port thoracoscopic lobectomy in the control group.In the experimental group, with the patient in the lateral position, double-lumen endotracheal tube placement was performed, followed by intravenous anesthesia and epidural anesthesia, and one-lung ventilation was given. A 3-cm incision was made between the 4th and 5th ribs in the anterior axillary line, followed by placement of a wound protection sleeve, where all surgical instruments were entered through this port. A 5-mm 30° lens was used to observe the thoracic cavity for the presence of adhesions and lobar fissures and lobulation. All operations were performed under the thoracoscope using long lumpectomy instruments, and the pulmonary arteries, bronchi, and interlobular fissures were treated with imported disposable cutting sutures. The patients underwent standard lung and mediastinal lymph node dissection, including intrapulmonary lymph nodes R2-4, 7, and 10 on the right side and L5, 7, and 10 on the left side. Routine postoperative paroxysms were given, and a chest drain was placed in this operation port.For the control group, a 1.5-cm incision was made in the 7th-8th intercostal space in the mid-axillary line, and a trocar was placed as the observation port. A 3-cm incision was then made in the 3rd or 4th intercostal space in the anterior axillary line, and a wound protection sleeve was placed as the main operation port, followed by a 1.5-cm incision made in the 5th or 6th intercostal space in the posterior axillary line as the secondary operation port. The surgical instruments, materials used, and lymph node dissection were the same as those in the experimental group.


## 2.6. Outcome

The outcomes are as follows:(1)
Baseline data: gender, weight, BMI, tumor stage, pathological type, tumor sites, and tumor size of patients(2)
Surgical indices: the surgical indices include operative time, incision length, intraoperative bleeding, intraoperative conversion to thoracotomy, number of lymph nodes dissection, postoperative drainage time, extubation time, length of hospital stay, and pain scores at different time points. The pain score was scaled per the postoperative numerical rating scale (NRS) [13], and the comparison of pain scores was carried out at 1 d, 3 d, and 7 d postoperatively. The NRS is a 10-point sliding scale with the number 1 to 10 for patients to describe their pain by circling out the number matching their conditions. The lower the score, the milder the pain(3)
Pain stress indices: 3 ml of morning fasting venous blood was collected from the eligible patients before and 7 d after surgery, and the levels of prostaglandin (PGE2), substance P (SP), and bradykinin (BK) were determined using a fully automated luminescence immunoassay analyzer (Roche Diagnostics GmbH, National Instrument Injection 20172222266)(4)
Incidence of postoperative complications: the postoperative complications of patients in both groups were recorded to calculate the incidence of complications in both groups


## 2.7. Statistical Analysis

SPSS 20.0 was used for data analyses, and GraphPad Prism 7 (GraphPad Software, San Diego, USA) was for image rendering. The count data were analyzed by the chi-square test, and the measurement data were analyzed by thet-test. Differences were considered statistically significant at P<0.05.


## 3. Results

### 3.1. Baseline Data

The two groups of eligible patients showed similar clinical baseline features (P>0.05). (Table 1).


### 3.2. Comparison of Surgical Indices

The experimental group outperformed the control group in terms of incision length, intraoperative bleeding, postoperative drainage time, extubation time, time to get out of bed, length of hospital stay, time to analgesics administration, and postoperative pain score (P<0.001). The operative time of the single-port thoracoscopic lobectomy was longer than that of the three-port thoracoscopic lobectomy (P<0.001). There was no statistical difference between the two groups in the intraoperative conversion to thoracotomy and the number of lymph node dissections (P>0.05) (Table 2).Table 2
Comparison of surgical indices.
GroupsExperimental group (n=100)Control group (n=100)X2/tPOperative time (min)167.98±12.12145.66±10.9813.648≤0.001Incision length (cm)5.21±0.327.50±0.5735.032≤0.001Intraoperative bleeding (ml)161.98±10.65179.65±14.209.955≤0.001Intraoperative conversion to thoracotomy (%)8.0(8/100)4(4/100)1.4180.234Number of lymph node dissection15.21±2.6515.87±2.401.8460.066Postoperative drainage time (d)3.24±0.215.04±0.2160.609≤0.001Extubation time (d)3.74±0.545.68±0.6024.033≤0.001Length of hospital stay (d)7.98±0.5610.46±1.2318.350≤0.001Pain scores (points)1 d postoperatively6.11±0.346.80±0.4711.895≤0.0013 d postoperatively3.21±0.324.26±0.3522.141≤0.0015 d postoperatively1.46±0.101.98±0.2519.312≤0.001


### 3.3. Comparison of Pain Stress Indices

Postoperative pain stress indices of the experimental group were significantly lower than those of the control group (P<0.001). The postoperative PGE2 levels in the experimental group were significantly lower than those in the control group (133.65±9.65 vs 172.54±9.65, t=28.497, P=0.000). Compared with the control group, the postoperative SP levels of the experimental group were significantly lower (5.11±0.45 vs 7.86±0.57, t=37.867, P=0.000). Compared with the control group, the postoperative BK level in the experimental group was significantly lower (5.32±0.43 vs 7.82±0.65, t=30.078, P=0.000). (Figures 1–3).Figure 1
Comparison of PGE2 levels (−x±s, pg/ml) Note: In Figure 1, the abscissa is preoperative and postoperative, and the ordinate is PGE2 level (pg/ml); the black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference in the preoperative PGE2 levels between the two groups (102.65±8.65 vs 102.70±8.66, t=0.041, P=0.968). The postoperative PGE2 levels in the experimental group were significantly lower than those in the control group (133.65±9.65 vs 172.54±9.65, t=28.497, P=0.000).Figure 2
Comparison of SP levels (−x±s, pg/ml) Note: In Figure 2, the abscissa is preoperative and postoperative, and the ordinate is SP level (μg/ml). The black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference between the preoperative SP levels of the two groups (3.87±0.54 vs 3.90±0.56, t=0.386, P=0.700). The postoperative SP levels of the experimental group were significantly lower than those of the control group (5.11±0.45 vs 7.86±0.57, t=37.867, P=0.000).Figure 3
Comparison of BK levels (−x±s, pg/ml) Note: In Figure 3, the abscissa is preoperative and postoperative, and the ordinate is the BK level (μg/L). The black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference between the preoperative BK levels of the two groups (4.70±0.40 vs 4.73±0.43, t=0.511, P=0.610). The postoperative BK level in the experimental group was significantly lower than that in the control group (5.32±0.43 vs 7.82±0.65, t=30.078, P=0.000).


### 3.4. Postoperative Complication

The experimental group had 0 (0.0%) cases of pulmonary arrhythmia, 2 (2.0%) cases of incisional infection, 4 (4.0%) cases of pleural effusion, and 2 (2.0%) cases of pneumothorax. The control group had 4 cases (4.0%) of pulmonary atelectasis, 4 cases (4.0%) of incisional infection, 8 cases (8.0%) of pleural effusion, 6 cases (6.0%) of pneumothorax, 4 cases (4.0%) of cardiac arrhythmia, 1 case (1.0%) of chest infection, 1 case (1.0%) of respiratory failure, 1 case (1.0%) of subcutaneous emphysema, and 1 case (1.0%) of postoperative bleeding. The incidence of complications in the experimental group was significantly lower than that in the control group (X2=15.725, P=0.000).


## 3.1. Baseline Data

The two groups of eligible patients showed similar clinical baseline features (P>0.05). (Table 1).


## 3.2. Comparison of Surgical Indices

The experimental group outperformed the control group in terms of incision length, intraoperative bleeding, postoperative drainage time, extubation time, time to get out of bed, length of hospital stay, time to analgesics administration, and postoperative pain score (P<0.001). The operative time of the single-port thoracoscopic lobectomy was longer than that of the three-port thoracoscopic lobectomy (P<0.001). There was no statistical difference between the two groups in the intraoperative conversion to thoracotomy and the number of lymph node dissections (P>0.05) (Table 2).Table 2
Comparison of surgical indices.
GroupsExperimental group (n=100)Control group (n=100)X2/tPOperative time (min)167.98±12.12145.66±10.9813.648≤0.001Incision length (cm)5.21±0.327.50±0.5735.032≤0.001Intraoperative bleeding (ml)161.98±10.65179.65±14.209.955≤0.001Intraoperative conversion to thoracotomy (%)8.0(8/100)4(4/100)1.4180.234Number of lymph node dissection15.21±2.6515.87±2.401.8460.066Postoperative drainage time (d)3.24±0.215.04±0.2160.609≤0.001Extubation time (d)3.74±0.545.68±0.6024.033≤0.001Length of hospital stay (d)7.98±0.5610.46±1.2318.350≤0.001Pain scores (points)1 d postoperatively6.11±0.346.80±0.4711.895≤0.0013 d postoperatively3.21±0.324.26±0.3522.141≤0.0015 d postoperatively1.46±0.101.98±0.2519.312≤0.001


## 3.3. Comparison of Pain Stress Indices

Postoperative pain stress indices of the experimental group were significantly lower than those of the control group (P<0.001). The postoperative PGE2 levels in the experimental group were significantly lower than those in the control group (133.65±9.65 vs 172.54±9.65, t=28.497, P=0.000). Compared with the control group, the postoperative SP levels of the experimental group were significantly lower (5.11±0.45 vs 7.86±0.57, t=37.867, P=0.000). Compared with the control group, the postoperative BK level in the experimental group was significantly lower (5.32±0.43 vs 7.82±0.65, t=30.078, P=0.000). (Figures 1–3).Figure 1
Comparison of PGE2 levels (−x±s, pg/ml) Note: In Figure 1, the abscissa is preoperative and postoperative, and the ordinate is PGE2 level (pg/ml); the black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference in the preoperative PGE2 levels between the two groups (102.65±8.65 vs 102.70±8.66, t=0.041, P=0.968). The postoperative PGE2 levels in the experimental group were significantly lower than those in the control group (133.65±9.65 vs 172.54±9.65, t=28.497, P=0.000).Figure 2
Comparison of SP levels (−x±s, pg/ml) Note: In Figure 2, the abscissa is preoperative and postoperative, and the ordinate is SP level (μg/ml). The black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference between the preoperative SP levels of the two groups (3.87±0.54 vs 3.90±0.56, t=0.386, P=0.700). The postoperative SP levels of the experimental group were significantly lower than those of the control group (5.11±0.45 vs 7.86±0.57, t=37.867, P=0.000).Figure 3
Comparison of BK levels (−x±s, pg/ml) Note: In Figure 3, the abscissa is preoperative and postoperative, and the ordinate is the BK level (μg/L). The black area in the figure is the experimental group, and the gray area is the control group. There was no statistical difference between the preoperative BK levels of the two groups (4.70±0.40 vs 4.73±0.43, t=0.511, P=0.610). The postoperative BK level in the experimental group was significantly lower than that in the control group (5.32±0.43 vs 7.82±0.65, t=30.078, P=0.000).


## 3.4. Postoperative Complication

The experimental group had 0 (0.0%) cases of pulmonary arrhythmia, 2 (2.0%) cases of incisional infection, 4 (4.0%) cases of pleural effusion, and 2 (2.0%) cases of pneumothorax. The control group had 4 cases (4.0%) of pulmonary atelectasis, 4 cases (4.0%) of incisional infection, 8 cases (8.0%) of pleural effusion, 6 cases (6.0%) of pneumothorax, 4 cases (4.0%) of cardiac arrhythmia, 1 case (1.0%) of chest infection, 1 case (1.0%) of respiratory failure, 1 case (1.0%) of subcutaneous emphysema, and 1 case (1.0%) of postoperative bleeding. The incidence of complications in the experimental group was significantly lower than that in the control group (X2=15.725, P=0.000).


## 4. Discussion

Lung lobectomy plus systemic lymph node dissection is the current standard radical lung cancer treatment, and early lung cancer surgery is currently effective in increasing the 5-year survival rate and improving the prognosis of patients [14]. Lobectomy mainly consists of open lobectomy and thoracoscopic lobectomy. Open lobectomy is the traditional radical lung cancer surgery, which involves a standard posterior lateral incision with a relatively long incision, high intraoperative bleeding, and significant postoperative pain, and slow recovery. Compared with traditional open lobectomy, thoracoscopic lobectomy is favored for a small incision and less postoperative pain [15, 16], so it is recommended by the NCCN as the preferred radical surgical procedure for nonsmall cell lung cancer patients without contraindications. According to relevant studies, thoracoscopic lobectomy can obtain similar therapeutic efficacy as open lobectomy [17, 18], and different branches of the technique were developed from the previous four-port and three-port surgical approaches to the two-port and single-port ones, which fewer incisions and less damage [19]. Kamigaichi Atsushi et al. found that the number and length of incisions were closely related to muscle, nerve, and vascular injuries in patients [18] because small incisions are less liable to chest muscles injury, which can reduce the stimulation of surgical operations on muscles and nerves. Moreover, the single-port operation allows for more effective hemostasis and less fluctuation of the patient’s cellular and humoral immunity [13, 20, 21]; thus, single-port operation avoids collateral damages to the adjacent tissues, reduces the stress response, and alleviates postoperative pain.This study showed that the incision length and intraoperative bleeding in the experimental group were significantly lower than those in the control group (P<0.001), and the patients had lower postoperative pain stress indices, indicating that the single-port operation was more effective in improving the perioperative indices of patients undergoing radical lung cancer surgery and better facilitated their postoperative recovery. The experimental group outperformed the control group in terms of postoperative drainage time, extubation time, time to get out of bed, the length of hospital stay, and the incidence of complication, suggesting the application value and a high safety profile of single-port thoracoscopic lobectomy. However, the longer operative time of the experimental group reflects the complicity of this method, and the difficulty of operation stems from the interference of the instruments in the sole operation port [6, 22]. Clinical practice experience indicates that the incision made on the 5th intercostal space results in increased difficulty in the management of transverse fissure of the right lung and interstitial fissure of the superior lingual segment of the left lung in patients, and therefore, the single-port method requires higher clinical experience of the surgeon. Yoo Jung Eun et al. suggested that clinicians should apply single-port operation with rich experience of three-port operation to shorten operative time and reduce the surgical risk [25], which ensures stable efficacy of single-port thoracoscopic lobectomy to achieve better clinical results.To sum up, single-port thoracoscopic lobectomy can improve the perioperative indices of lung cancer patients, reduce their pain stress response, and accelerate postoperative recovery. However, its operation is difficult and time-consuming, requiring experienced surgeons for improved surgical outcomes in practice.



---

*Source: 3434430-2022-05-14.xml*