# Smoking Cessation in Long-Term Conditions: Is There “An Opportunity in Every Difficulty”?

Authors: Kamran Siddiqi; Omara F. Dogar; Najma Siddiqi
Journal: International Journal of Population Research
 (2013)

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## Abstract

Introduction. Smoking plays a causal role in several long-term conditions and worsens their outcomes. Focusing on six such conditions, we present a narrative review of seminal studies on the prevalence and impact of continued tobacco use on these conditions; the effectiveness of cessation interventions; the extent to which patients receive these interventions, and barriers to providing and taking up these interventions. Methods. A conceptual framework was used to identify questions for a series of focused literature reviews. Findings were synthesized and the literature was examined to identify themes common across these conditions. Results. Smoking prevalence is either similar or higher in patients with established long-term conditions compared to the general population. Continued smoking accelerates disease progression, worsens outcomes, and risks poor treatment compliance or further complications. There is strong evidence for the effectiveness of cessation interventions in achieving smoking abstinence. Despite this, only a small proportion of patients receive such interventions. Important barriers to uptake include concerns about weight management and drug safety, higher nicotine dependency and codependency, comorbidity, and misperceptions about the benefits of cessation. Conclusion. The benefits of offering smoking cessation in patients with long-term conditions are far too great for it to remain of a low priority.


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## Body

## 1. Introduction

Tobacco use is responsible for 5.5 million deaths and 4% of the global burden of disease in terms of disability adjusted life-years [1]. Tobacco’s causal association with several long-term conditions (e.g., coronary heart disease (CHD), chronic obstructive pulmonary disease (COPD)) has long been established [2, 3]. In others (e.g., diabetes, schizophrenia), although tobacco does not play a causal role, its use is thought to worsen outcomes [4]. Using six prevalent long-term conditions as examples, CHD, diabetes, COPD, asthma, schizophrenia, and HIV/AIDS, we examine whether tobacco cessation in patients with established long-term conditions deserves a stronger focus than it currently receives. In this paper, we highlight some of the pivotal studies relevant to (i) the prevalence and impact of continued tobacco use on the outcomes of these conditions; (ii) the effectiveness and cost-effectiveness of cessation interventions; (iii) the extent to which patients receive cessation interventions, and (iv) key barriers to providing and taking up of these interventions. By highlighting some of the seminal work carried out in this area in recent years, this paper aims to identify the gaps in provision of smoking cessation interventions for people with long-term conditions and to help to reenergise efforts to address this important aspect of tobacco control.


## 2. Materials and Methods

Our review questions (Table1) were based on a conceptual framework consisting of four fundamental blocks (Figure 1). We set out to review the literature on patients with established long-term conditions (CHD, diabetes, COPD, schizophrenia, asthma, and HIV/AIDS) examining.Table 1
Questions and key words for the literature search.
Questionsin patients with establishedlong-term conditions
Study designs included
Search terms
Specific terms
Interventions
Behaviours
Long term conditions
Need
What is the prevalence of smoking?
National surveys, cohort studies
Prevalence, frequency, use, prevalent, survey
Smoking, cigarette smoking, tobacco dependence, chewing tobacco, smokeless tobacco, andtobacco smoking
Coronary artery disease,acute coronary syndrome,coronary arteriosclerosis,myocardial infarction, andischemic heart disease Diabetes mellitus, type 2 diabetesmellitus, and adult onset diabetes mellitus Chronic obstructive pulmonary disease, chronic obstructivelung disease, chronic obstructive airways disease, pulmonary emphysema, and emphysema Asthma and bronchial asthma Schizophrenia, schizoaffectivedisorder, and psychosis HIV, acquired immune deficiency syndrome, and acquired immune deficiency syndrome virus
What is the effect of continued smoking on their outcomes?
Cohort studies
Cohort, cohort study, case-control study, cohort analysis
Benefit
What is the effectiveness and cost-effectiveness of smoking cessation interventions in achieving abstinence?
Systematic reviews and randomized controlled trials
clinical trials, randomized, controlled clinical trials, randomized, and randomized controlled trial
What is the feasibility of delivering smoking cessation interventions?
Surveys, qualitative and mixed methods studies
Feasibility, practicality, feasible, and practical
Smoking cessation, nicotine replacement, tobaccocessation, counselling, bupropion, varenicline, and tobacco cessation
What is the acceptability of smoking cessation interventions?
Surveys, qualitative and mixed methods studies
Acceptable, acceptability, appropriateness, appropriate
What is the effect of smoking cessation on their disease outcomes?
Cohort studies, cohort analyses, randomized controlled trials, and controlled trials
Cohort, cohort study, case-control study, cohort analysisclinical trials, randomized,  controlled clinical trials, randomized, and randomized controlled trial
Gap
To what extent they receive smoking cessation interventions as part of their routine care?
Surveys, audits, and qualitative and mixed methods studies
Service provision, service gap, provision, access, accessible, accessibility, available, availability, offer, provide, give, service
Barriers
What are the barriers in providing and accessing smoking cessation interventions?
Surveys, qualitative and mixed methods studies
Constraint, barrier, challenge, difficulty, hurdle, limitation, obstacle, and blockFigure 1
Tobacco cessation and long-term conditions—a conceptual framework.Need—the prevalence of tobacco use and the effect of continued smoking on outcomes.Capacity to benefit—the effectiveness and cost-effectiveness of tobacco cessation interventions in achieving abstinence; the acceptability and feasibility of these interventions from patients’ and providers’ perspectives, respectively; and the impact of cessation on patient outcomes.Gap—gaps in provision of cessation services and in uptake among patients.Barriers—barriers to accessing cessation services from both patients’ and providers’ perspectives.A series of focused literature reviews were carried out. We prospectively agreed appropriate study designs and search terms for each question separately (details in Table1). These were combined with search terms for smoking and its use, cessation interventions, and the six long-term conditions to identify relevant citations for each question. We searched Cochrane and PubMed databases for articles published in the English language between January 1992 and October 2012. We also examined reference lists of selected articles, to avoid missing any important and relevant work. Findings were synthesized and the literature was also examined to identify themes common across all of these long-term conditions.


## 3. Results

Given the nature and range of questions, articles selected for this overview used a variety of research designs including multicountry surveys, longitudinal studies, randomised controlled trials, and quasi-experimental and qualitative studies. Settings, participants, and outcomes also varied; almost all studies were from high-income countries.


### 3.1. Smoking Prevalence in Long-Term Conditions

Globally, approximately 20% of the adult population smoke cigarettes on a regular basis [5]. Smoking is at least prevalent in patients with long-term conditions. A multi-country European survey (EUROASPIRE) reported that 21% of CHD patients continue to smoke after being diagnosed [6]. In patients with diabetes mellitus, prevalence is between 15 and 20% [7–10] and in COPD it is 26% [11]. A survey, Global Asthma Prevalence in Adults, found that 24% of people with asthma (on treatment) were current smokers [12]; in developing countries, smoking prevalence is as high as 30% among adults with asthma [13]. In mental illness, smoking is at least twice as common as in the general population [14, 15], and in people with schizophrenia, it is six times higher [16, 17]. People living with HIV and AIDS are three times more likely to be smokers than general public (59% versus 20%) [18, 19], mainly because HIV risk behaviours cluster among certain populations, in which smoking is also very common.


### 3.2. Impact of Continued Smoking

Continued smoking with long-term conditions contributes towards excess mortality and morbidity by expediting disease progression, worsening outcomes, increasing complication rates, and reducing treatment compliance.People who continue to smoke after acute myocardial infarction (AMI) are twice as likely to die compared to those who have never smoked or those who quit just before or after the event [20]. Smokers also have a 70% risk of recurrence of AMI [21]. In a large cohort study, in people with established CHD, the relative risk (RR) for further coronary events for heavy smokers (>15 cigarettes/day) compared to nonsmokers was 2.68 (95% CI, 2.07–3.48), with a lower but still increased risk for exsmokers and for moderate smokers (<15 cigarettes/day) [22]. Mortality was also higher for current smokers compared to non-smokers [23].Among diabetics, smoking acts as an independent risk factor for rapid progression to kidney disease [24], retinopathy [25], and sensory neuropathies [26]. Around 80% of COPD-associated morbidity is attributable to smoking [27]. In those who continue to smoke, the forced expiratory volume in one-second (FEV1) declines at an accelerated rate compared to those who quit [28, 29]. Risk of hospitalization and chest infections is also higher [30, 31]. Mortality rates for COPD are higher in current smokers (1.04–2.61) than in ex-smokers (0.64) and never smokers (0.11) [32].Smoking in adult asthmatics is associated with worse symptom control, increased admissions for exacerbations, deterioration of pulmonary functions, and increased mortality [33–35]. Smoking also impairs the efficacy of oral corticosteroid treatment in asthma [36]. Almost two-thirds of deaths in people with schizophrenia are caused by CHD compared to only one-half in the general population. Such patients have a 20% shorter life expectancy; most of it is attributable to smoking [37, 38]. For 35–54-year-old patients with schizophrenia, the hazard ratio for mortality for smokers versus non-smokers is 2.0 [39].Smoking is a strong predictor of poor quality of life, morbidity, and mortality in people living with HIV/AIDS [40, 41]. Smoking is of particular concern in HIV/AIDS due to the high background risk of cardiovascular disease, dyslipidemia, insulin resistance, and susceptibility to COPD and lung cancers [42–44]. It is also associated with risk of developing bacterial pneumonia [45] and AIDS-related pneumocystis pneumonia (PCP) [46]. Compared to former and never smokers combined, the Population Attributable Fraction (PAF%) for current smokers with HIV/AIDS is 24.3% for overall mortality, 25.3% for major cardiovascular disease, 30.6% for non-AIDS cancer, and 25.4% for bacterial pneumonia [47]. In addition, smoking increases the incidence of periodontal disease, oral candidiasis, and hairy leukoplakia [48]. Smoking during pregnancy is associated with a threefold increase in the risk of vertical HIV transmission [49]. Smoking is also correlated with lower drug adherence [50].


### 3.3. Smoking Cessation

#### 3.3.1. Effectiveness and Cost-Effectiveness

There is strong evidence (16 RCTs) for the effectiveness of smoking cessation interventions in achieving continuous abstinence in patients with CHD (OR: 1.66, 95%CI: 1.25–2.22) [51]. Face-to-face behavioural support, telephone support, and self-help were all similar in effectiveness, but more intensive interventions achieved higher quit rates (OR: 1.98, 95%CI: 1.49–2.65) compared to brief interventions (OR: 0.92, 95%CI: 0.70–1.22). In patients with diabetes, training primary care staff in motivational interviewing led to a threefold increase in quit rates in the intervention group (20%) compared to controls (7%) [52]. Another study showed that training diabetes nurses in smoking cessation could significantly increase quit rates (17% versus 2.3%) [53]. In COPD patients, a Cochrane review (five RCTs; two, high quality) concluded, behavioural and pharmacological interventions combined are superior to usual care or behavioural intervention alone in achieving sustained abstinence [54]. A combination of counselling and nicotine replacement therapy (NRT) (RR: 4.19, 95%  CI: 3.41–5.15) or bupropion (RR: 1.74, 95%  CI: 1.01–3.00) was effective compared to usual care [55, 56]. Another review (9 RCTs and 4 systematic reviews) concluded that sustained abstinence is higher in COPD patients receiving behavioural intervention both with (pooled RR: 4.28, 95%  CI: 3.51–5.20) and without (pooled RR: 5.85, 95%  CI: 3.81–8.97) NRT when compared with usual care [57]. The effectiveness of interventions for smoking cessation has not been investigated specifically in patients with asthma.In people with schizophrenia, there is good evidence that bupropion is effective in achieving cessation (RR, 2.78; 95%  CI; 1.02–7.58) at six months without any adverse effects on mental health [58]. Similarly, varenicline is also effective in achieving higher cessation rates (19% versus 4.7%) compared to placebo in such patients without an increase in adverse effects [59].Few definitive studies have assessed the effectiveness of smoking cessation in people living with HIV/AIDS. A recent paper reviewed eight studies (four RCTs), two with an adequate sample size [60]. Most of these studies used NRT with or without counselling. Results of the larger trials were promising (modest effect size with moderate quality) but highlighted that more intensive treatment is required to sustain abstinence in this group.Smoking cessation is highly cost-effective in patients with cardiovascular diseases; the incremental cost per Quality Adjusted Life Years (QALY) for smoking cessation (varenicline plus behavioural support) is €6120 in Belgium, €5151 in Spain, €5357 in Portugal, and €5433 in Italy [61]. It is also highly cost-effective in patients with diabetes; the incremental cost per QALY is around $8,000 for individuals aged between 45 and 74 [62]. A cost-utility analysis in COPD patients showed that, compared to usual care, the costs per QALY for minimal counselling (<90 minutes), intensive counselling (>90 minutes), and intensive counselling and pharmacotherapy, were €16,900, €8200, and €2400, respectively [63].


#### 3.3.2. Feasibility and Acceptability

Patients with long-term conditions are generally more receptive to smoking cessation messages with several “teachable moments” during their care. One study found high motivation levels among patients with AMI and described how smoking cessation advice can be improved accordingly [64]. Similarly, patients with diabetes, hypertension, and CHD have higher motivation to quit and desire to receive support compared to the general population [65]. Adolescents with asthma expressed higher levels of willingness to quit and acceptance of support than those without asthma [66]. Around 40–63% of people living with HIV/AIDS are motivated to quit with a positive interest in cessation, which is equivalent to the general smoker population [19].


#### 3.3.3. Impact on Long-Term Conditions

Smoking cessation benefits patients with long-term conditions by improving outcomes. There is strong evidence that cessation leads to a 36% risk reduction in mortality in patients with established CHD [22, 23, 67]. In patients with type 2 diabetes, smoking cessation leads to a reduction in the rate of complications. One study demonstrated an improvement in metabolic parameters, lowered blood pressure, and reduction of microalbuminuria [68]. Among those with microalbuminuria, smoking cessation ameliorates progression to end stage renal disease [69]. In COPD, mortality rates decline progressively after smoking cessation but are still elevated in comparison with never smokers [32, 70]. A sizeable minority of smokers with COPD (20%) who receive long-term oxygen therapy often die from severe burns and inhalation injuries due to accidents caused by smoking whilst receiving oxygen therapy [71]. Cessation can prevent such accidents. In people with asthma, smoking cessation improves quality of life and reduces use of β2 agonists, daytime symptoms, bronchial reactivity, and inhaled corticosteroids dose [72]. In HIV/AIDS, smoking cessation leads to a significant reduction in HIV-related symptoms [73]. We did not find any studies on schizophrenia in this category.


### 3.4. Gap in Service Provision

There are very few studies investigating the provision of smoking cessation interventions for people with long-term conditions. However, the evidence does indicate a provision gap. For CHD patients, it often relies on the availability and access to cardiac rehabilitation and secondary prevention services. The majority of smokers with CHD receive either verbal (72.9%) and/or written (25.4%) advice to quit [74]. Only 9.6% are referred to a smoking cessation service, and of these, only 11.4% are prescribed NRT and 5.8% bupropion. In another survey, 42% of smokers with diabetes did not receive any cessation support [75]. In a study in Kerala, India, only half of diabetic patients who also smoked tobacco received advice to quit from their doctor [76]. A US-based study suggests that the majority of dentists do not offer cessation advice to diabetic patients who smoke. They see smoking cessation as a marginal activity and do not perceive it to be a service expected from them [77]. Patients with schizophrenia are 30% less likely to receive cessation advice compared to people with other mental illnesses and to the general population [78]. A survey found that although two-thirds of psychiatrists asked about patient’s smoking status, only one-third offered cessation advice [79]. HIV healthcare providers are less likely to assess smoking status and to feel confident in offering cessation advice to patients with HIV compared to other health providers [80].


### 3.5. Patient Related Barriers

#### 3.5.1. Weight Management Issues

For people with diabetes, a major constraint in making an intention to quit is concern about potential weight gain [81]. Such concerns are also shared by COPD and HIV patients, citing weight management as a major reason for not intending to quit [82]. People with HIV tend to gain more weight after quitting than non-HIV patients [82]. Moreover, some patients use smoking to manage lipodystrophy related to antiretroviral therapy [80].


#### 3.5.2. Awareness and Motivation

Patients with CHD, who have other comorbidities such as COPD and depression, have low motivation to quit after AMI [83, 84]. Patients with diabetes who continue to smoke are generally more depressed less likely to self-manage and to maintain good glucose control [85]. They are often less motivated to quit than the general population [85]. In a study in India, 52% of patients with diabetes who smoked were not aware of the associated risks [76]. Similarly, in Indonesia, most smokers with diabetes did not associate the risk of developing diabetic complications with smoking [86]. Patients with COPD are more likely to develop depression and anxiety, which adversely affect cessation attempts. However, they are more motivated to receive support once they have decided to quit [82]. Patients with schizophrenia are less motivated to quit compared to general smokers [87, 88]. Most of them think that smoking helps to alleviate negative symptoms and cognitive deficits, enhances cognitive performance, and provides psychomotor stimulation [17, 89]. Generally, people with schizophrenia feel less confident about being successful in quitting and have concerns about their coping ability and potential negative symptoms following quitting [90].


#### 3.5.3. Dependency and Codependency

Patients with high nicotine dependency (Fagerstrom score ≥ 8) are less likely to quit than those who are less dependent [83]. Smokers with COPD have a higher nicotine dependency than healthy smokers (mean Fagerstrom score, 4.77 versus 3.15, resp.) [91]. People living with HIV/AIDS who smoke also have high nicotine dependency [92]. They are likely to have codependencies too, such as alcohol and substance misuse, which makes them more vulnerable to withdrawal symptoms on quitting and means that sustained abstinence is more difficult to achieve compared to those without HIV [19]. Psychiatric comorbidity such as depression is also common and is associated with low motivation to quit [80].


#### 3.5.4. Misperceptions

A sizeable minority of smokers with diabetes believe that smoking is “beneficial” and quitting can have a deleterious effect on their diabetes [93]. Some COPD patients, who continue to smoke, do so with the belief that “the damage has already been done” [94]. There are also some unsubstantiated beliefs that quitting smoking exacerbates the negative symptoms of schizophrenia [95]. Some people living with HIV/AIDS trivialise health risks associated with smoking and see it as a “helpful” coping aid [96].


#### 3.5.5. Other Barriers

People living with HIV/AIDS are more likely to be socioeconomically disadvantaged compared to the general smoker population [19]. This affects access to cessation interventions, which tend to involve additional expenditure [19].


### 3.6. Provider Related Barriers

#### 3.6.1. Perceived Lack of Relevance

Primary care providers who believe that their patients are not willing to quit are less inclined to offer cessation counselling to them [97, 98]. The perceptions of nurses delivering smoking cessation counselling to home-bound medically ill patients about the relevance, effectiveness (quit attempts), and outcomes (successful quits) of cessation advice are found to be significantly correlated with their counselling behaviours. Nurses who believe that patients would quit as a result of their counselling tend to spend more time in counselling them [99]. Smoking cessation has long been considered irrelevant to HIV/AIDS due to perceived poor outcomes. However, since the success of antiretroviral therapy, attitudes towards smoking cessation have changed considerably both among providers and patients [80]. With people with HIV/AIDS living longer, concerns about developing other associated chronic conditions and cancers have raised the importance of quitting [80].


#### 3.6.2. Own Smoking Behaviour

Nurses, both in general and speciality care, who are themselves current smokers, are less likely to arrange follow-up discussions about quitting smoking with patients [97]. Self-efficacy (confidence in own ability to counsel patients who smoke) is also found to be higher among nonsmoking health providers and positively predicts arranging patient followup for smoking cessation advice [99].


#### 3.6.3. Just Focus on Treating the Condition

Lack of motivation, opportunity, and capacity among healthcare staff are some of the barriers in delivering cessation interventions [97, 100, 101]. Nurses and doctors are often not motivated to deliver cessation interventions as they perceive it to be outside their roles. A survey of US physicians found that whilst the majority (62%) were confident about their knowledge of the benefits of smoking cessation, few (14%) offered it in practice [102]. High patient volume and complexity of the health issues in presenting patients are also reported as factors that limit the time available for effective smoking cessation counseling [103]. Nurses report lack of time and skills in advising people with diabetes in lifestyle changes including smoking cessation [104]. In a US study of psychiatric nurses, the majority acknowledged the importance of providing smoking cessation to their patients but only a quarter offered any cessation advice [105].


#### 3.6.4. Concerns about Drugs Safety

Another barrier is the concern about safety of NRT, bupropion, and varenicline in patients with cardiovascular conditions due to their possible hemodynamic effects [106, 107]. Whilst such concerns may be justified on the basis of pharmacodynamics profiles, clinical studies have found no evidence of increased risk of cardiovascular events associated with these treatments [106]. Studies to-date have been relatively small and may, therefore, have missed potential adverse effects; there is a general consensus that the benefits of cessation interventions outweigh the risks of any potential, yet unsubstantiated, safety concerns. Similarly, concerns have been raised about using varenicline in people with schizophrenia. A recent review, however, reported a brief negative psychiatric episode in only three out of 260 patients with stable schizophrenia [108]. No excess adverse events were found in those who used bupropion in such patients [109].


## 3.1. Smoking Prevalence in Long-Term Conditions

Globally, approximately 20% of the adult population smoke cigarettes on a regular basis [5]. Smoking is at least prevalent in patients with long-term conditions. A multi-country European survey (EUROASPIRE) reported that 21% of CHD patients continue to smoke after being diagnosed [6]. In patients with diabetes mellitus, prevalence is between 15 and 20% [7–10] and in COPD it is 26% [11]. A survey, Global Asthma Prevalence in Adults, found that 24% of people with asthma (on treatment) were current smokers [12]; in developing countries, smoking prevalence is as high as 30% among adults with asthma [13]. In mental illness, smoking is at least twice as common as in the general population [14, 15], and in people with schizophrenia, it is six times higher [16, 17]. People living with HIV and AIDS are three times more likely to be smokers than general public (59% versus 20%) [18, 19], mainly because HIV risk behaviours cluster among certain populations, in which smoking is also very common.


## 3.2. Impact of Continued Smoking

Continued smoking with long-term conditions contributes towards excess mortality and morbidity by expediting disease progression, worsening outcomes, increasing complication rates, and reducing treatment compliance.People who continue to smoke after acute myocardial infarction (AMI) are twice as likely to die compared to those who have never smoked or those who quit just before or after the event [20]. Smokers also have a 70% risk of recurrence of AMI [21]. In a large cohort study, in people with established CHD, the relative risk (RR) for further coronary events for heavy smokers (>15 cigarettes/day) compared to nonsmokers was 2.68 (95% CI, 2.07–3.48), with a lower but still increased risk for exsmokers and for moderate smokers (<15 cigarettes/day) [22]. Mortality was also higher for current smokers compared to non-smokers [23].Among diabetics, smoking acts as an independent risk factor for rapid progression to kidney disease [24], retinopathy [25], and sensory neuropathies [26]. Around 80% of COPD-associated morbidity is attributable to smoking [27]. In those who continue to smoke, the forced expiratory volume in one-second (FEV1) declines at an accelerated rate compared to those who quit [28, 29]. Risk of hospitalization and chest infections is also higher [30, 31]. Mortality rates for COPD are higher in current smokers (1.04–2.61) than in ex-smokers (0.64) and never smokers (0.11) [32].Smoking in adult asthmatics is associated with worse symptom control, increased admissions for exacerbations, deterioration of pulmonary functions, and increased mortality [33–35]. Smoking also impairs the efficacy of oral corticosteroid treatment in asthma [36]. Almost two-thirds of deaths in people with schizophrenia are caused by CHD compared to only one-half in the general population. Such patients have a 20% shorter life expectancy; most of it is attributable to smoking [37, 38]. For 35–54-year-old patients with schizophrenia, the hazard ratio for mortality for smokers versus non-smokers is 2.0 [39].Smoking is a strong predictor of poor quality of life, morbidity, and mortality in people living with HIV/AIDS [40, 41]. Smoking is of particular concern in HIV/AIDS due to the high background risk of cardiovascular disease, dyslipidemia, insulin resistance, and susceptibility to COPD and lung cancers [42–44]. It is also associated with risk of developing bacterial pneumonia [45] and AIDS-related pneumocystis pneumonia (PCP) [46]. Compared to former and never smokers combined, the Population Attributable Fraction (PAF%) for current smokers with HIV/AIDS is 24.3% for overall mortality, 25.3% for major cardiovascular disease, 30.6% for non-AIDS cancer, and 25.4% for bacterial pneumonia [47]. In addition, smoking increases the incidence of periodontal disease, oral candidiasis, and hairy leukoplakia [48]. Smoking during pregnancy is associated with a threefold increase in the risk of vertical HIV transmission [49]. Smoking is also correlated with lower drug adherence [50].


## 3.3. Smoking Cessation

### 3.3.1. Effectiveness and Cost-Effectiveness

There is strong evidence (16 RCTs) for the effectiveness of smoking cessation interventions in achieving continuous abstinence in patients with CHD (OR: 1.66, 95%CI: 1.25–2.22) [51]. Face-to-face behavioural support, telephone support, and self-help were all similar in effectiveness, but more intensive interventions achieved higher quit rates (OR: 1.98, 95%CI: 1.49–2.65) compared to brief interventions (OR: 0.92, 95%CI: 0.70–1.22). In patients with diabetes, training primary care staff in motivational interviewing led to a threefold increase in quit rates in the intervention group (20%) compared to controls (7%) [52]. Another study showed that training diabetes nurses in smoking cessation could significantly increase quit rates (17% versus 2.3%) [53]. In COPD patients, a Cochrane review (five RCTs; two, high quality) concluded, behavioural and pharmacological interventions combined are superior to usual care or behavioural intervention alone in achieving sustained abstinence [54]. A combination of counselling and nicotine replacement therapy (NRT) (RR: 4.19, 95%  CI: 3.41–5.15) or bupropion (RR: 1.74, 95%  CI: 1.01–3.00) was effective compared to usual care [55, 56]. Another review (9 RCTs and 4 systematic reviews) concluded that sustained abstinence is higher in COPD patients receiving behavioural intervention both with (pooled RR: 4.28, 95%  CI: 3.51–5.20) and without (pooled RR: 5.85, 95%  CI: 3.81–8.97) NRT when compared with usual care [57]. The effectiveness of interventions for smoking cessation has not been investigated specifically in patients with asthma.In people with schizophrenia, there is good evidence that bupropion is effective in achieving cessation (RR, 2.78; 95%  CI; 1.02–7.58) at six months without any adverse effects on mental health [58]. Similarly, varenicline is also effective in achieving higher cessation rates (19% versus 4.7%) compared to placebo in such patients without an increase in adverse effects [59].Few definitive studies have assessed the effectiveness of smoking cessation in people living with HIV/AIDS. A recent paper reviewed eight studies (four RCTs), two with an adequate sample size [60]. Most of these studies used NRT with or without counselling. Results of the larger trials were promising (modest effect size with moderate quality) but highlighted that more intensive treatment is required to sustain abstinence in this group.Smoking cessation is highly cost-effective in patients with cardiovascular diseases; the incremental cost per Quality Adjusted Life Years (QALY) for smoking cessation (varenicline plus behavioural support) is €6120 in Belgium, €5151 in Spain, €5357 in Portugal, and €5433 in Italy [61]. It is also highly cost-effective in patients with diabetes; the incremental cost per QALY is around $8,000 for individuals aged between 45 and 74 [62]. A cost-utility analysis in COPD patients showed that, compared to usual care, the costs per QALY for minimal counselling (<90 minutes), intensive counselling (>90 minutes), and intensive counselling and pharmacotherapy, were €16,900, €8200, and €2400, respectively [63].


### 3.3.2. Feasibility and Acceptability

Patients with long-term conditions are generally more receptive to smoking cessation messages with several “teachable moments” during their care. One study found high motivation levels among patients with AMI and described how smoking cessation advice can be improved accordingly [64]. Similarly, patients with diabetes, hypertension, and CHD have higher motivation to quit and desire to receive support compared to the general population [65]. Adolescents with asthma expressed higher levels of willingness to quit and acceptance of support than those without asthma [66]. Around 40–63% of people living with HIV/AIDS are motivated to quit with a positive interest in cessation, which is equivalent to the general smoker population [19].


### 3.3.3. Impact on Long-Term Conditions

Smoking cessation benefits patients with long-term conditions by improving outcomes. There is strong evidence that cessation leads to a 36% risk reduction in mortality in patients with established CHD [22, 23, 67]. In patients with type 2 diabetes, smoking cessation leads to a reduction in the rate of complications. One study demonstrated an improvement in metabolic parameters, lowered blood pressure, and reduction of microalbuminuria [68]. Among those with microalbuminuria, smoking cessation ameliorates progression to end stage renal disease [69]. In COPD, mortality rates decline progressively after smoking cessation but are still elevated in comparison with never smokers [32, 70]. A sizeable minority of smokers with COPD (20%) who receive long-term oxygen therapy often die from severe burns and inhalation injuries due to accidents caused by smoking whilst receiving oxygen therapy [71]. Cessation can prevent such accidents. In people with asthma, smoking cessation improves quality of life and reduces use of β2 agonists, daytime symptoms, bronchial reactivity, and inhaled corticosteroids dose [72]. In HIV/AIDS, smoking cessation leads to a significant reduction in HIV-related symptoms [73]. We did not find any studies on schizophrenia in this category.


## 3.3.1. Effectiveness and Cost-Effectiveness

There is strong evidence (16 RCTs) for the effectiveness of smoking cessation interventions in achieving continuous abstinence in patients with CHD (OR: 1.66, 95%CI: 1.25–2.22) [51]. Face-to-face behavioural support, telephone support, and self-help were all similar in effectiveness, but more intensive interventions achieved higher quit rates (OR: 1.98, 95%CI: 1.49–2.65) compared to brief interventions (OR: 0.92, 95%CI: 0.70–1.22). In patients with diabetes, training primary care staff in motivational interviewing led to a threefold increase in quit rates in the intervention group (20%) compared to controls (7%) [52]. Another study showed that training diabetes nurses in smoking cessation could significantly increase quit rates (17% versus 2.3%) [53]. In COPD patients, a Cochrane review (five RCTs; two, high quality) concluded, behavioural and pharmacological interventions combined are superior to usual care or behavioural intervention alone in achieving sustained abstinence [54]. A combination of counselling and nicotine replacement therapy (NRT) (RR: 4.19, 95%  CI: 3.41–5.15) or bupropion (RR: 1.74, 95%  CI: 1.01–3.00) was effective compared to usual care [55, 56]. Another review (9 RCTs and 4 systematic reviews) concluded that sustained abstinence is higher in COPD patients receiving behavioural intervention both with (pooled RR: 4.28, 95%  CI: 3.51–5.20) and without (pooled RR: 5.85, 95%  CI: 3.81–8.97) NRT when compared with usual care [57]. The effectiveness of interventions for smoking cessation has not been investigated specifically in patients with asthma.In people with schizophrenia, there is good evidence that bupropion is effective in achieving cessation (RR, 2.78; 95%  CI; 1.02–7.58) at six months without any adverse effects on mental health [58]. Similarly, varenicline is also effective in achieving higher cessation rates (19% versus 4.7%) compared to placebo in such patients without an increase in adverse effects [59].Few definitive studies have assessed the effectiveness of smoking cessation in people living with HIV/AIDS. A recent paper reviewed eight studies (four RCTs), two with an adequate sample size [60]. Most of these studies used NRT with or without counselling. Results of the larger trials were promising (modest effect size with moderate quality) but highlighted that more intensive treatment is required to sustain abstinence in this group.Smoking cessation is highly cost-effective in patients with cardiovascular diseases; the incremental cost per Quality Adjusted Life Years (QALY) for smoking cessation (varenicline plus behavioural support) is €6120 in Belgium, €5151 in Spain, €5357 in Portugal, and €5433 in Italy [61]. It is also highly cost-effective in patients with diabetes; the incremental cost per QALY is around $8,000 for individuals aged between 45 and 74 [62]. A cost-utility analysis in COPD patients showed that, compared to usual care, the costs per QALY for minimal counselling (<90 minutes), intensive counselling (>90 minutes), and intensive counselling and pharmacotherapy, were €16,900, €8200, and €2400, respectively [63].


## 3.3.2. Feasibility and Acceptability

Patients with long-term conditions are generally more receptive to smoking cessation messages with several “teachable moments” during their care. One study found high motivation levels among patients with AMI and described how smoking cessation advice can be improved accordingly [64]. Similarly, patients with diabetes, hypertension, and CHD have higher motivation to quit and desire to receive support compared to the general population [65]. Adolescents with asthma expressed higher levels of willingness to quit and acceptance of support than those without asthma [66]. Around 40–63% of people living with HIV/AIDS are motivated to quit with a positive interest in cessation, which is equivalent to the general smoker population [19].


## 3.3.3. Impact on Long-Term Conditions

Smoking cessation benefits patients with long-term conditions by improving outcomes. There is strong evidence that cessation leads to a 36% risk reduction in mortality in patients with established CHD [22, 23, 67]. In patients with type 2 diabetes, smoking cessation leads to a reduction in the rate of complications. One study demonstrated an improvement in metabolic parameters, lowered blood pressure, and reduction of microalbuminuria [68]. Among those with microalbuminuria, smoking cessation ameliorates progression to end stage renal disease [69]. In COPD, mortality rates decline progressively after smoking cessation but are still elevated in comparison with never smokers [32, 70]. A sizeable minority of smokers with COPD (20%) who receive long-term oxygen therapy often die from severe burns and inhalation injuries due to accidents caused by smoking whilst receiving oxygen therapy [71]. Cessation can prevent such accidents. In people with asthma, smoking cessation improves quality of life and reduces use of β2 agonists, daytime symptoms, bronchial reactivity, and inhaled corticosteroids dose [72]. In HIV/AIDS, smoking cessation leads to a significant reduction in HIV-related symptoms [73]. We did not find any studies on schizophrenia in this category.


## 3.4. Gap in Service Provision

There are very few studies investigating the provision of smoking cessation interventions for people with long-term conditions. However, the evidence does indicate a provision gap. For CHD patients, it often relies on the availability and access to cardiac rehabilitation and secondary prevention services. The majority of smokers with CHD receive either verbal (72.9%) and/or written (25.4%) advice to quit [74]. Only 9.6% are referred to a smoking cessation service, and of these, only 11.4% are prescribed NRT and 5.8% bupropion. In another survey, 42% of smokers with diabetes did not receive any cessation support [75]. In a study in Kerala, India, only half of diabetic patients who also smoked tobacco received advice to quit from their doctor [76]. A US-based study suggests that the majority of dentists do not offer cessation advice to diabetic patients who smoke. They see smoking cessation as a marginal activity and do not perceive it to be a service expected from them [77]. Patients with schizophrenia are 30% less likely to receive cessation advice compared to people with other mental illnesses and to the general population [78]. A survey found that although two-thirds of psychiatrists asked about patient’s smoking status, only one-third offered cessation advice [79]. HIV healthcare providers are less likely to assess smoking status and to feel confident in offering cessation advice to patients with HIV compared to other health providers [80].


## 3.5. Patient Related Barriers

### 3.5.1. Weight Management Issues

For people with diabetes, a major constraint in making an intention to quit is concern about potential weight gain [81]. Such concerns are also shared by COPD and HIV patients, citing weight management as a major reason for not intending to quit [82]. People with HIV tend to gain more weight after quitting than non-HIV patients [82]. Moreover, some patients use smoking to manage lipodystrophy related to antiretroviral therapy [80].


### 3.5.2. Awareness and Motivation

Patients with CHD, who have other comorbidities such as COPD and depression, have low motivation to quit after AMI [83, 84]. Patients with diabetes who continue to smoke are generally more depressed less likely to self-manage and to maintain good glucose control [85]. They are often less motivated to quit than the general population [85]. In a study in India, 52% of patients with diabetes who smoked were not aware of the associated risks [76]. Similarly, in Indonesia, most smokers with diabetes did not associate the risk of developing diabetic complications with smoking [86]. Patients with COPD are more likely to develop depression and anxiety, which adversely affect cessation attempts. However, they are more motivated to receive support once they have decided to quit [82]. Patients with schizophrenia are less motivated to quit compared to general smokers [87, 88]. Most of them think that smoking helps to alleviate negative symptoms and cognitive deficits, enhances cognitive performance, and provides psychomotor stimulation [17, 89]. Generally, people with schizophrenia feel less confident about being successful in quitting and have concerns about their coping ability and potential negative symptoms following quitting [90].


### 3.5.3. Dependency and Codependency

Patients with high nicotine dependency (Fagerstrom score ≥ 8) are less likely to quit than those who are less dependent [83]. Smokers with COPD have a higher nicotine dependency than healthy smokers (mean Fagerstrom score, 4.77 versus 3.15, resp.) [91]. People living with HIV/AIDS who smoke also have high nicotine dependency [92]. They are likely to have codependencies too, such as alcohol and substance misuse, which makes them more vulnerable to withdrawal symptoms on quitting and means that sustained abstinence is more difficult to achieve compared to those without HIV [19]. Psychiatric comorbidity such as depression is also common and is associated with low motivation to quit [80].


### 3.5.4. Misperceptions

A sizeable minority of smokers with diabetes believe that smoking is “beneficial” and quitting can have a deleterious effect on their diabetes [93]. Some COPD patients, who continue to smoke, do so with the belief that “the damage has already been done” [94]. There are also some unsubstantiated beliefs that quitting smoking exacerbates the negative symptoms of schizophrenia [95]. Some people living with HIV/AIDS trivialise health risks associated with smoking and see it as a “helpful” coping aid [96].


### 3.5.5. Other Barriers

People living with HIV/AIDS are more likely to be socioeconomically disadvantaged compared to the general smoker population [19]. This affects access to cessation interventions, which tend to involve additional expenditure [19].


## 3.5.1. Weight Management Issues

For people with diabetes, a major constraint in making an intention to quit is concern about potential weight gain [81]. Such concerns are also shared by COPD and HIV patients, citing weight management as a major reason for not intending to quit [82]. People with HIV tend to gain more weight after quitting than non-HIV patients [82]. Moreover, some patients use smoking to manage lipodystrophy related to antiretroviral therapy [80].


## 3.5.2. Awareness and Motivation

Patients with CHD, who have other comorbidities such as COPD and depression, have low motivation to quit after AMI [83, 84]. Patients with diabetes who continue to smoke are generally more depressed less likely to self-manage and to maintain good glucose control [85]. They are often less motivated to quit than the general population [85]. In a study in India, 52% of patients with diabetes who smoked were not aware of the associated risks [76]. Similarly, in Indonesia, most smokers with diabetes did not associate the risk of developing diabetic complications with smoking [86]. Patients with COPD are more likely to develop depression and anxiety, which adversely affect cessation attempts. However, they are more motivated to receive support once they have decided to quit [82]. Patients with schizophrenia are less motivated to quit compared to general smokers [87, 88]. Most of them think that smoking helps to alleviate negative symptoms and cognitive deficits, enhances cognitive performance, and provides psychomotor stimulation [17, 89]. Generally, people with schizophrenia feel less confident about being successful in quitting and have concerns about their coping ability and potential negative symptoms following quitting [90].


## 3.5.3. Dependency and Codependency

Patients with high nicotine dependency (Fagerstrom score ≥ 8) are less likely to quit than those who are less dependent [83]. Smokers with COPD have a higher nicotine dependency than healthy smokers (mean Fagerstrom score, 4.77 versus 3.15, resp.) [91]. People living with HIV/AIDS who smoke also have high nicotine dependency [92]. They are likely to have codependencies too, such as alcohol and substance misuse, which makes them more vulnerable to withdrawal symptoms on quitting and means that sustained abstinence is more difficult to achieve compared to those without HIV [19]. Psychiatric comorbidity such as depression is also common and is associated with low motivation to quit [80].


## 3.5.4. Misperceptions

A sizeable minority of smokers with diabetes believe that smoking is “beneficial” and quitting can have a deleterious effect on their diabetes [93]. Some COPD patients, who continue to smoke, do so with the belief that “the damage has already been done” [94]. There are also some unsubstantiated beliefs that quitting smoking exacerbates the negative symptoms of schizophrenia [95]. Some people living with HIV/AIDS trivialise health risks associated with smoking and see it as a “helpful” coping aid [96].


## 3.5.5. Other Barriers

People living with HIV/AIDS are more likely to be socioeconomically disadvantaged compared to the general smoker population [19]. This affects access to cessation interventions, which tend to involve additional expenditure [19].


## 3.6. Provider Related Barriers

### 3.6.1. Perceived Lack of Relevance

Primary care providers who believe that their patients are not willing to quit are less inclined to offer cessation counselling to them [97, 98]. The perceptions of nurses delivering smoking cessation counselling to home-bound medically ill patients about the relevance, effectiveness (quit attempts), and outcomes (successful quits) of cessation advice are found to be significantly correlated with their counselling behaviours. Nurses who believe that patients would quit as a result of their counselling tend to spend more time in counselling them [99]. Smoking cessation has long been considered irrelevant to HIV/AIDS due to perceived poor outcomes. However, since the success of antiretroviral therapy, attitudes towards smoking cessation have changed considerably both among providers and patients [80]. With people with HIV/AIDS living longer, concerns about developing other associated chronic conditions and cancers have raised the importance of quitting [80].


### 3.6.2. Own Smoking Behaviour

Nurses, both in general and speciality care, who are themselves current smokers, are less likely to arrange follow-up discussions about quitting smoking with patients [97]. Self-efficacy (confidence in own ability to counsel patients who smoke) is also found to be higher among nonsmoking health providers and positively predicts arranging patient followup for smoking cessation advice [99].


### 3.6.3. Just Focus on Treating the Condition

Lack of motivation, opportunity, and capacity among healthcare staff are some of the barriers in delivering cessation interventions [97, 100, 101]. Nurses and doctors are often not motivated to deliver cessation interventions as they perceive it to be outside their roles. A survey of US physicians found that whilst the majority (62%) were confident about their knowledge of the benefits of smoking cessation, few (14%) offered it in practice [102]. High patient volume and complexity of the health issues in presenting patients are also reported as factors that limit the time available for effective smoking cessation counseling [103]. Nurses report lack of time and skills in advising people with diabetes in lifestyle changes including smoking cessation [104]. In a US study of psychiatric nurses, the majority acknowledged the importance of providing smoking cessation to their patients but only a quarter offered any cessation advice [105].


### 3.6.4. Concerns about Drugs Safety

Another barrier is the concern about safety of NRT, bupropion, and varenicline in patients with cardiovascular conditions due to their possible hemodynamic effects [106, 107]. Whilst such concerns may be justified on the basis of pharmacodynamics profiles, clinical studies have found no evidence of increased risk of cardiovascular events associated with these treatments [106]. Studies to-date have been relatively small and may, therefore, have missed potential adverse effects; there is a general consensus that the benefits of cessation interventions outweigh the risks of any potential, yet unsubstantiated, safety concerns. Similarly, concerns have been raised about using varenicline in people with schizophrenia. A recent review, however, reported a brief negative psychiatric episode in only three out of 260 patients with stable schizophrenia [108]. No excess adverse events were found in those who used bupropion in such patients [109].


## 3.6.1. Perceived Lack of Relevance

Primary care providers who believe that their patients are not willing to quit are less inclined to offer cessation counselling to them [97, 98]. The perceptions of nurses delivering smoking cessation counselling to home-bound medically ill patients about the relevance, effectiveness (quit attempts), and outcomes (successful quits) of cessation advice are found to be significantly correlated with their counselling behaviours. Nurses who believe that patients would quit as a result of their counselling tend to spend more time in counselling them [99]. Smoking cessation has long been considered irrelevant to HIV/AIDS due to perceived poor outcomes. However, since the success of antiretroviral therapy, attitudes towards smoking cessation have changed considerably both among providers and patients [80]. With people with HIV/AIDS living longer, concerns about developing other associated chronic conditions and cancers have raised the importance of quitting [80].


## 3.6.2. Own Smoking Behaviour

Nurses, both in general and speciality care, who are themselves current smokers, are less likely to arrange follow-up discussions about quitting smoking with patients [97]. Self-efficacy (confidence in own ability to counsel patients who smoke) is also found to be higher among nonsmoking health providers and positively predicts arranging patient followup for smoking cessation advice [99].


## 3.6.3. Just Focus on Treating the Condition

Lack of motivation, opportunity, and capacity among healthcare staff are some of the barriers in delivering cessation interventions [97, 100, 101]. Nurses and doctors are often not motivated to deliver cessation interventions as they perceive it to be outside their roles. A survey of US physicians found that whilst the majority (62%) were confident about their knowledge of the benefits of smoking cessation, few (14%) offered it in practice [102]. High patient volume and complexity of the health issues in presenting patients are also reported as factors that limit the time available for effective smoking cessation counseling [103]. Nurses report lack of time and skills in advising people with diabetes in lifestyle changes including smoking cessation [104]. In a US study of psychiatric nurses, the majority acknowledged the importance of providing smoking cessation to their patients but only a quarter offered any cessation advice [105].


## 3.6.4. Concerns about Drugs Safety

Another barrier is the concern about safety of NRT, bupropion, and varenicline in patients with cardiovascular conditions due to their possible hemodynamic effects [106, 107]. Whilst such concerns may be justified on the basis of pharmacodynamics profiles, clinical studies have found no evidence of increased risk of cardiovascular events associated with these treatments [106]. Studies to-date have been relatively small and may, therefore, have missed potential adverse effects; there is a general consensus that the benefits of cessation interventions outweigh the risks of any potential, yet unsubstantiated, safety concerns. Similarly, concerns have been raised about using varenicline in people with schizophrenia. A recent review, however, reported a brief negative psychiatric episode in only three out of 260 patients with stable schizophrenia [108]. No excess adverse events were found in those who used bupropion in such patients [109].


## 4. Discussion

We found that smoking prevalence is either similar or higher in patients with established long-term conditions compared to the general population. There is evidence from good quality longitudinal studies to suggest that continued smoking in patients with these conditions accelerates disease progression, worsens outcomes, and risks poor treatment compliance or further complications. There is strong evidence for the effectiveness in achieving smoking abstinence of behavioural support alone in CHD, behavioural support in combination with NRT or bupropion in COPD, and pharmacotherapy (varenicline and bupropion) in schizophrenia. Although there are fewer good quality studies for diabetes and HIV/AIDS, the limited evidence does suggest effectiveness in these conditions also. Studies have also shown considerable benefits of smoking cessation in improving disease outcomes.The need and potential to benefit from cessation interventions in long-term conditions seem to be clear. However, there is a significant gap in provision. A large proportion of patients with CHD, diabetes, and schizophrenia do not receive even brief cessation advice and only a minority obtain specialist advice or cessation interventions. This gap is due to a number of barriers, including concerns about weight management in patients with diabetes and schizophrenia and drug safety in those with CHD and schizophrenia. Higher nicotine dependency in COPD patients and codependency in HIV/AIDS make cessation even more challenging. Comorbidity and misperceptions about the efficacy and benefits of cessation influence patients’ motivation to quit. Health professionals often do not prioritise cessation or consider it as part of mainstream management, which further contributes towards this service gap.This is not a systematic review, and therefore, it does neither provide a comprehensive evidence synthesis for each question nor has it offered a qualitative appraisal of the studies included. We have conducted a narrative review on the topic using broad terms and inclusion criteria in order to highlight some of the seminal studies and knowledge gaps.Our findings have implications for future research and for service provision. Knowledge of smoking prevalence in patients with long-term conditions is key to plan and target cessation services; yet we found few studies specifically of smoking prevalence in such patients and most estimates for prevalence were derived from studies with other primary aims. We found no smoking cessation trials in patients with asthma and very few high quality trials in HIV/AIDS. In general, most trials were exploratory and, except for a few studies in diabetes, did not test service models for delivering smoking cessation within the general management of long-term conditions. Nonpharmacological interventions were often poorly defined, making it difficult to assess the underlying behaviour change techniques used. We suggest, therefore, that there is an urgent need for further studies of smoking prevalence and trials testing well-defined interventions and service models for smoking cessation in long-term conditions. In the last few years, knowledge has emerged on effective behaviour change techniques in smoking cessation [110] making it apposite to develop interventions based on these techniques that are relevant to long-term conditions. Future research on behavioural support interventions needs to determine the best ways to integrate these within existing models of care. Future trials should also include economic evaluations, particularly in patients with schizophrenia, diabetes, and HIV/AIDS, where there are concerns that more intensive cessation treatment might be required to achieve cessation rates comparable to the general population. Such trials should also assess the impact of cessation on outcomes of these conditions. Further research is also required to understand the barriers to service provision, as the literature on this is limited to only a few conditions and is particularly sparse on the perspectives of health providers.Although the true extent of the gap in providing cessation support in long-term conditions is unclear (and in COPD, asthma, and HIV/AIDS, it has not been investigated at all), the available evidence suggests that it is likely to be significant. This is of concern, given the established need and potential to benefit in these conditions. Moreover, the increased frequency of contact with health services for people with these conditions presents an opportunity. Recording and reporting smoking status and offering cessation interventions should be integral to the management of long-term conditions. We may, as yet, not be aware of the most effective and cost-effective models of service provision and ways to address barriers and concerns. However, there is sufficient evidence of the benefits to mandate that smoking cessation support should be implemented as an integral part of the management of long-term conditions.



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