# Sacral Neuromodulation: Foray into Chronic Pelvic Pain in End Stage Endometriosis

Authors: Maija Lavonius; Pia Suvitie; Pirita Varpe; Heikki Huhtinen
Journal: Case Reports in Neurological Medicine
 (2017)

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## Abstract

Excision of all endometriotic lesions is the method of choice in the treatment of severe endometriosis resistant to medical therapy. The infiltrating nature of the disease as well as extensive surgery may, however, cause chronic pain that cannot be relieved by either surgery or hormonal treatment. As a pilot treatment, we tested the effect of sacral neuromodulation (SNM) for four endometriosis patients suffering chronic pelvic pain and pelvic organ dysfunction after radical surgical treatment. Three out of four patients reported improvement in their symptoms during the neuromodulation testing period and a permanent pulse generator was installed. After 2.5 years, all three patients report better quality of life and want to continue with SNM.


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## Body

## 1. Introduction

Sacral neuromodulation (SNM) involves electrical modulation of a sacral nerve root by means of an electrode and a pulse generator. The conventional indications for SNM are urinary retention, urinary incontinence, anal incontinence, and constipation [1]. Several studies have also demonstrated promising results of SNM in chronic pelvic pain [2], although its mechanism of action remains ill defined [3]. One study has evaluated the effect of SNM on voiding dysfunction after surgery for deep infiltrating (DIE) endometriosis [4]. To our knowledge, no reports of SNM for the treatment of pelvic pain after radical surgery of endometriosis have been published.Endometriosis is an estrogen-dependent chronic inflammatory disease defined by the presence of functional endometrial tissue outside the uterine cavity. Approximately 4–10% of women are affected during their fertile years suffering from a variety of pelvic pain symptoms and subfertility [5]. Endometriosis significantly reduces health-related quality of life (HRQoL) mostly due to pain symptoms [6]. Pain can be alleviated with hormonal medication and nonsteroidal anti-inflammatory drugs (NSAID) [7]. When medical therapy fails, complete surgical excision of the endometriotic lesions is the method of choice. In severe DIE, a multidisciplinary approach can be necessary.Endometriosis can cause pain in many different mechanisms [8]. Irritation of pelvic nerves due to inflammation causes nociceptive pain. In addition, DIE can infiltrate pelvic nerves causing pain, and de novo nerve growth is also detected in ectopic endometrial tissue. During surgery, all efforts are made to preserve the pelvic nerves. However, in severe cases, nerve-sparing technique is not possible if the goal is to remove all endometriosis. In such cases, a compromise is made between radicalness of surgery and preservation of pelvic organ function. The disease itself as well as extensive surgery can lead to chronic neuropathic pain. In such cases, little options are available to ease the pain.


## 2. Case Presentation

Common to all our four patients was a history of surgically treated deep infiltrating endometriosis in lateral pelvic sidewalls affecting ureters, sacrouterine ligaments, and pelvic nerves. All women had undergone hysterectomy and bilateral salpingo-oophorectomy combined with excision of all macroscopic endometriosis. Thus, adenomyosis as the source of pain was excluded. No recurrent endometriosis was suspected in gynecological examination and transvaginal ultrasound, and the chronic noncyclical pelvic pain was life interfering and resistant to hormonal and medical treatment. Detailed surgical history is presented in Table1. All women were fully informed of the experimental nature of the SNM treatment for this indication. No ethics approval was applied because of acknowledged use of SNM for other indications with pelvic disorders. SNM was offered to one more patient but she declined because she feared the procedure.Table 1
Surgical history of the four women in the neuromodulation pilot study. Operations were performed by laparotomy if laparoscopy is not mentioned in the text.
Patient
Age(years)
year
Operation
Indication
Postoperativecomplications
1G2P2
1999
Laparoscopy
Endometriosis
None
2000
Laparoscopic left salpingo-oophorectomy
Endometriosis
None
2000
Laparoscopic right salpingo-oophorectomy, supracervical hysterectomy
Endometriosis
None
2009
Adhesiolysis and extirpation of the uterine cervix
Pelvic pain
None
2011
Anterior resection, appendicectomy, and adhesiolysis
Pelvic pain (left side)
None
43
2014
Neuromodulation test period and a permanent pulse generator installation (right S4)
Pelvic pain
None
2G0P0
2002
Left salpingo-oophorectomy and adhesiolysis
Endometriosis
None
2006
Anterior resection and ileostomy
Sigmoid perforation
Rectal anastomosis stricture
2007
Reanterior resection and ileostomy closure
None
2009
Adhesiolysis, ileum resection, and supracervical hysterectomy
Postoperative adhesions, bowel obstruction
None
2013
Re-reanterior resection, resection of left ureter, extirpation of the uterine cervix, and ileostomy
Endometriosis (main symptom pain) and anal incontinence and defecation difficulties
Ureteral anastomosis leakage treated by pyelostomy and drainage
2013
Ileostomy closure
None
50
2014
Neuromodulation test period and a permanent pulse generator installation (left S4)
Pelvic pain and defecation difficulties
None
3G2P2
1991
Laparoscopy
Endometriosis
None
1995
Laparoscopy
Endometriosis
None
2003
Laparoscopic excision of sacrouterine ligaments and electrocoagulation of peritoneal endometriosis
Endometriosis
None
2005
Laparoscopic electrocoagulation of peritoneal endometriosis and adhesiolysis
Endometriosis
None
2008
Hysterectomy and excision of peritoneal endometriosis
Endometriosis
None
2010
Laparoscopic adhesiolysis and left salpingo-oophorectomy
Postoperative adhesions, pain, left ovarian cyst
None
2010
Vaginal resection, extirpation of left periureteral endometriosis
Endometriosis, hydronephrosis
Laparotomy wound infection
42
2014
Neuromodulation testing period and a permanent pulse generator installation (right S4)
Pelvic pain and defecation difficulties
None
4G1P0
2011
Hysterectomy and bilateral salpingectomy
Endometriosis
None
2012
Ileum resection, appendicectomy, bilateral oophorectomy, vaginal resection, and resection of left sacrouterine ligament
Endometriosis, pelvic pain
None
35
2014
Neuromodulation testing period (left S3)
Pelvic pain
None
Note. G: gravidity, P: parity.The SNM procedure with InterStim II™ system was performed in two stages. In the first stage, a permanent lead was implanted under local anesthesia with fluoroscopic control into S3 or S4 sacral foramina as described in detail earlier [3]. In our patients, the permanent lead was implanted into the foramen with the best motor and sensory response in the testing phase (Table 1). In the second stage, permanent pulse generator was implanted for the patients with significant objective relief of symptoms after 3-4 weeks testing period with external pulse generator. In those with negative symptom relief, the lead was removed under local anesthesia.A self-designed disease-related questionnaire was used to assess pelvic pain symptoms as well as bowel and urogenital function before and 3–6 months after SNM procedure. This questionnaire evaluated the presence of abdominal or pelvic pain or dyspareunia; functional bowel symptoms like pain and difficulties on defecation, fecal incontinence, or constipation; urinary symptoms like incomplete bladder emptying, dysuria, and urinary incontinence. In addition, patients were advised to keep daily pain diary and pain medication diary for fourteen days before, during, and after SNM test period. Furthermore, women with permanent pulse generator were asked to evaluate the effect of SNM treatment to pelvic pain symptoms and bowel and bladder function 3–6 months after procedure (1: worse, 2: no change, 3: somewhat improved, 4: much improved, 5: excellent improvement). Women’s subjective satisfaction on SNM was evaluated with numerical rating scale (NRS) (0 meaning totally unsatisfied and 10 meaning totally satisfied). During the treatment and follow-up, women had the possibility for daily contact with study nurse.Main pre-SNM symptoms and self-reported response to treatment are shown in Table2.Table 2
Main pre-SNM symptoms and response to SNM treatment.
Patient
1
2
3
Time point to SNM
Pre
0.5 yrs
2.5 yrs
Pre
0.5 yrs
2.5 yrs
Pre
0.5 yrs
2.5 yrs
Symptom
Abdominal or pelvic pain
yes
4
5
yes
4
4
yes
3
4
Dyspareunia
yes
4
3
yes
4
3
yes
na
na
Dyschezia or bowel colic
yes
5
4
yes
4
4
no
na
na
Constipation, outlet obstruction
yes
5
3
no
na
na
yes
4
5
Anal incontinence
yes
5
4
yes
4
3
no
na
na
Dysuria
no
na
na
yes
4
5
no
na
na
Voiding dysfunction
yes
4
2
no
na
na
no
na
na
Urinary incontinence
yes
4
2
yes
4
4
no
na
na
Satisfaction to SNM (NRS)
8
8
9
9
9
10
Compared to pre-SNM status:
1: worse, 2: no change, 3: somewhat improved, 4: much improved, 5: excellent improvement.
NRS: numerical rating scale 0–10.
na: not applicable.After the test period, three patients reported considerable or excellent improvement (NRS 8-9) in subjective quality of life and were offered to have permanent pulse generator installed. Two women found considerable improvement in bladder symptoms and two women found considerable or excellent relief in dyspareunia. All these three women found that SNM relieved chronic pelvic pain a little, but the pain was easier to tolerate when functional pelvic symptoms eased. Total use of pain medication decreased, but only one woman filled the questionnaire fully adequately regarding NRS values and pain medication.Patient number four did not experience any improvement in symptoms during the test period. Permanent pulse generator was not installed. She did not return any of the questionnaires.We organized a phone call control to all four patients 2.5 years after the test period. All three patients with SNM installed wanted to continue with SNM. None of the patients with SNM were totally symptom-free but they all reported better quality of life by better symptom control enabling working, social life, and travelling. Main pre-SNM symptom for patient 1 was disabling chronic pain and defecation problems. She got excellent help for pain and dyspareunia from SNM but the first modulator had to be removed because of infection. Second modulator gave good pain control but it has not been as good with dyspareunia. For good symptom control, she has needed SNM reprogramming 2-3 times a year. Patient 2 announced that chronic pelvic pain and pain during defecation had eased as well as fecal and urinary incontinence. Patient 3 had excellent help for obstipation and lived a regular life. She was fully satisfied with SNM. Fourth patient has retired in the age of 38 and suffers chronic pelvic pain, functional bowel symptoms, dysuria, and dyspareunia. No spontaneous symptom mitigation has occurred during 2.5 years. She underwent full clinical and radiological reevaluation with MRI year 2015 and has tried all hormonal treatments and pain killers without help.


## 3. Discussion

Our clinical experience is that deep endometriotic nodules at area of uterosacral ligaments with infiltration to hypogastric nerves and the ureters create the most difficult disease to treat. Possibilities of surgery are limited by preservation of vascular, urinary, and neural structures. Nature of the pain is often neurogenic and response to hormonal treatment and regular pain medication is poor. Luckily, this end stage is rare but those few patients may end up being quite desperate.SNM has been used for pelvic floor pain and functional pelvic disorders for other indications but not for endometriosis [9]. We decided to propose SNM on experimental basis for women who had tried all other possible treatments.A self-administered disease-related questionnaire was used to assess problems with bowel and urogenital functions, but the compliance was poor. After the SNM test period, three out of four patients announced significant relief in their symptoms and a permanent pulse generator was implanted. NRS did not turn out to be reliable indicator of pain since the heavy use of pain medication in the beginning of study biased the results. However, three out of four patients were able to reduce pain medication. These three women also felt that problems with defecation and urinary symptoms were alleviated significantly. In addition, two women got a remarkable help for dyspareunia and reported great increase in subjective quality of life. All three patients want to continue with the SNM after 2.5 years. Fourth patient who did not benefit from SNM has not experienced any spontaneous relief in symptoms during 2.5 years.We are fully aware of the placebo effect of SNM. However, since three out of four patients with chronic pelvic pain and pelvic floor dysfunction reported a clinically plausible benefit of this pilot trial, we believe that SNM for end stage endometriosis patients is worth further controlled studies.



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*Source: 2197831-2017-03-06.xml*