# Determinants of Under-Five Mortality in High Mortality Regions of Ethiopia: An Analysis of the 2011 Ethiopia Demographic and Health Survey Data

Authors: Solomon Gebretsadik; Emmanuel Gabreyohannes
Journal: International Journal of Population Research
 (2016)

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## Abstract

The study was a secondary analysis of existing data from the 2011 Ethiopia Demographic and Health Survey data. Of the 2097 live births recorded in Affar, Somali, Benishangul-Gumuz, and Gambela regions of Ethiopia between 2006 and 2011, 366 deaths before the age of five years were reported. The univariable and multivariable Cox proportional regression models were fitted to select the factors affecting under-five mortality in these regions. The model revealed that under-five mortality significantly associated with preceding birth interval, family size, birth type, breastfeeding status, source of drinking water, and income of mother. Children born after a preceding birth interval of 2-3 years and 3 years and above were significantly less likely to have died before their fifth birthday than those born within two years. Children who were breastfed, for any period, were 25.5% (HR 1.255, 1.005–1.567,p = 0.045) less likely to have died before their fifth birthday than those who were not breastfed. Increased birth interval time corresponds to a low probability of child mortality. Thus, mothers should be encouraged to wait for a sufficient number of months after a birth to conceive another child. Furthermore, breastfeeding was of paramount importance in the fight against child mortality.


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## Body

## 1. Background

Under-five mortality is a leading indicator of child health and overall development of a nation, as it reflects the social, economic, and environmental conditions in which children (and others in society) live, including their healthcare [1].Worldwide, 5.9 million children below five years of age died in 2015. The risk of a child dying before completing five years of age is still the highest in the World Health Organization (WHO) African countries (81 per 1000 live births), about 7 times higher than in the WHO European region (11 per 1000 live births). Low-income countries reported 76 deaths per 1000 live births, about 11 times the average rate in high-income countries (7 deaths per 1000 live births) [2]. Sub-Saharan Africa continues to confront significant challenges, as the region with the highest child mortality rates in the world: 98 deaths per 1,000 live births in 2012. All 16 countries with an under-five mortality rate above 100 deaths per 1,000 live births are in sub-Saharan Africa [3]. While progress in child health has been made over the past five years in Ethiopia with the under-five mortality rate reducing from 123 to 88 deaths per 1,000 live births, the death rate is intolerably high as one in 11 children did not live beyond their fifth birthday [4]. In addition, some regions in Ethiopia are characterized by higher rates of child mortality. For instance, according to 2011 Ethiopia Demographic and Health Survey (2011 EDHS) data, under-five mortality rates per 1000 live births for Affar were 127, for Somali were 122, for Benishangul-Gumuz were 169, and for Gambela were 123 for the year 2010/2011 [4]. Thus, this study tries to explore the major risk factors of under-five mortality taking into consideration various demographic, socioeconomic, and environmental factors in these regions of Ethiopia.Child health is determined by many factors including parental education, access to health services, and income of families [5]. According to Mosley and Chen (1984), child mortality is determined by a combination of socioeconomic, biological, environmental, and behavioral factors [6].Earlier studies conducted in Brazil, Kenya, and southwest Ethiopia reported that under-five mortality is influenced by socioeconomic status [7–9], birth weight [10], mother’s age [8], place of residence, mother’s age, mother’s education, place of delivery, birth order, sex of child, religion of parents, household headship, and household socioeconomic status [11–15].


## 2. Methods

### 2.1. Source of Data

The 2011 EDHS is the third DHS in Ethiopia, following the 2000 and 2005 EDHS surveys. The 2011 EDHS used a two-stage stratified sampling technique to select a sample of households for the data collection. In the first stage, 624 enumeration areas were randomly selected: 187 in urban areas and 437 in rural areas. In the second stage, a fixed number of 30 households were selected for each EA. Of the 18,720 selected households, 5,610 were in urban areas and 13,110 were in rural areas. All women aged 15–49, living permanently in the selected households or present in the household on the night before the survey visit, were eligible to be interviewed in the EDHS. In 2011 EDHS, a total of 17,385 eligible women were identified and interviews were completed for 16515 women, yielding a response rate of 95 percent. Information for this study was taken from the birth history section of the 2011 EDHS Women’s Questionnaire.


### 2.2. Study Design

The study design was a retrospective study which analyzed data from the 2011 EDHS.


### 2.3. Study Population

The study population was all women who had given birth to a live infant in the preceding 5 years.


### 2.4. Data Availability

The DHS data used for this study are openly available and can be downloaded fromhttp://www.measuredhs.com/data/available-datasets.cfm?inputSearch=ETHIOPIA.


### 2.5. Variables in the Study

#### 2.5.1. The Dependent Variable

The dependent variable of the study is duration of time from date of birth until date of death or censor (if the child survives past 59 months).


#### 2.5.2. Explanatory (Covariates) Variables

The main predictors explored for under-five mortality for this study were taken from Mosley and Chen (1984) determinants of childhood morbidity and mortality framework for developing countries [6], similar studies, and available data on the subject. We grouped them into demographic, socioeconomic, and environmental factors. All are presented in Table 1.Table 1
Description of socioeconomic, demographic, and environment related covariates.
Number Description and name Notation Categories (1) Sex of child SEX 1 = male, 2 = female (2) Type of birth BTYPE 0 = single birth, 1 = multiple births (3) Mother’s age at first birth of child MAGEB 0 =≤16 years, 1 = >16 years (4) Family size FSIZE 0 = 1–3 members, 1 = 4–6 members, 2 =≥7 members (5) Breastfeeding status BFDINGS 0 = no, 1 = yes (6) Preceding birth interval PBITVAL 0 =≤2 years, 1 = 2-3 years, 2 = ≥3 years (7) Mother’s education MEDU 0 = no education, 1 = primary and above (8) Father’s education FEDU 0 = no education, 1 = primary and above (9) Area of residence ARISD 1 = urban, 2 = rural (10) Marital status MSTAT 0 = married, 1 = not married (11) Income of mother relative to her husband MINCOM 0 = more than husband, 1 = less than husband (12) Source of drinking water SDWTR 0 = pipe, 1 = others


### 2.6. Method of Data Analysis

In this study, survival analysis was conducted to find out the determinants of under-five mortality in four selected regions of Ethiopia. This comprised Kaplan–Meier with log-rank test and Cox proportional hazard regression model. The data analysis was done using SPSS 20, STATA, and SAS statistical (software) packages.


### 2.7. Ethical Considerations

The protocol for the EDHS was approved by the Ethiopia Health and Nutrition Research Institute Review Board, National Research Ethics Review Committee (NRERC) at the Federal Democratic Republic of Ethiopia Ministry of Science and Technology, the Institutional Review Board of ICF Macro, and the Centers for Disease Control and Prevention (CDC) in Atlanta.


## 2.1. Source of Data

The 2011 EDHS is the third DHS in Ethiopia, following the 2000 and 2005 EDHS surveys. The 2011 EDHS used a two-stage stratified sampling technique to select a sample of households for the data collection. In the first stage, 624 enumeration areas were randomly selected: 187 in urban areas and 437 in rural areas. In the second stage, a fixed number of 30 households were selected for each EA. Of the 18,720 selected households, 5,610 were in urban areas and 13,110 were in rural areas. All women aged 15–49, living permanently in the selected households or present in the household on the night before the survey visit, were eligible to be interviewed in the EDHS. In 2011 EDHS, a total of 17,385 eligible women were identified and interviews were completed for 16515 women, yielding a response rate of 95 percent. Information for this study was taken from the birth history section of the 2011 EDHS Women’s Questionnaire.


## 2.2. Study Design

The study design was a retrospective study which analyzed data from the 2011 EDHS.


## 2.3. Study Population

The study population was all women who had given birth to a live infant in the preceding 5 years.


## 2.4. Data Availability

The DHS data used for this study are openly available and can be downloaded fromhttp://www.measuredhs.com/data/available-datasets.cfm?inputSearch=ETHIOPIA.


## 2.5. Variables in the Study

### 2.5.1. The Dependent Variable

The dependent variable of the study is duration of time from date of birth until date of death or censor (if the child survives past 59 months).


### 2.5.2. Explanatory (Covariates) Variables

The main predictors explored for under-five mortality for this study were taken from Mosley and Chen (1984) determinants of childhood morbidity and mortality framework for developing countries [6], similar studies, and available data on the subject. We grouped them into demographic, socioeconomic, and environmental factors. All are presented in Table 1.Table 1
Description of socioeconomic, demographic, and environment related covariates.
Number Description and name Notation Categories (1) Sex of child SEX 1 = male, 2 = female (2) Type of birth BTYPE 0 = single birth, 1 = multiple births (3) Mother’s age at first birth of child MAGEB 0 =≤16 years, 1 = >16 years (4) Family size FSIZE 0 = 1–3 members, 1 = 4–6 members, 2 =≥7 members (5) Breastfeeding status BFDINGS 0 = no, 1 = yes (6) Preceding birth interval PBITVAL 0 =≤2 years, 1 = 2-3 years, 2 = ≥3 years (7) Mother’s education MEDU 0 = no education, 1 = primary and above (8) Father’s education FEDU 0 = no education, 1 = primary and above (9) Area of residence ARISD 1 = urban, 2 = rural (10) Marital status MSTAT 0 = married, 1 = not married (11) Income of mother relative to her husband MINCOM 0 = more than husband, 1 = less than husband (12) Source of drinking water SDWTR 0 = pipe, 1 = others


## 2.5.1. The Dependent Variable

The dependent variable of the study is duration of time from date of birth until date of death or censor (if the child survives past 59 months).


## 2.5.2. Explanatory (Covariates) Variables

The main predictors explored for under-five mortality for this study were taken from Mosley and Chen (1984) determinants of childhood morbidity and mortality framework for developing countries [6], similar studies, and available data on the subject. We grouped them into demographic, socioeconomic, and environmental factors. All are presented in Table 1.Table 1
Description of socioeconomic, demographic, and environment related covariates.
Number Description and name Notation Categories (1) Sex of child SEX 1 = male, 2 = female (2) Type of birth BTYPE 0 = single birth, 1 = multiple births (3) Mother’s age at first birth of child MAGEB 0 =≤16 years, 1 = >16 years (4) Family size FSIZE 0 = 1–3 members, 1 = 4–6 members, 2 =≥7 members (5) Breastfeeding status BFDINGS 0 = no, 1 = yes (6) Preceding birth interval PBITVAL 0 =≤2 years, 1 = 2-3 years, 2 = ≥3 years (7) Mother’s education MEDU 0 = no education, 1 = primary and above (8) Father’s education FEDU 0 = no education, 1 = primary and above (9) Area of residence ARISD 1 = urban, 2 = rural (10) Marital status MSTAT 0 = married, 1 = not married (11) Income of mother relative to her husband MINCOM 0 = more than husband, 1 = less than husband (12) Source of drinking water SDWTR 0 = pipe, 1 = others


## 2.6. Method of Data Analysis

In this study, survival analysis was conducted to find out the determinants of under-five mortality in four selected regions of Ethiopia. This comprised Kaplan–Meier with log-rank test and Cox proportional hazard regression model. The data analysis was done using SPSS 20, STATA, and SAS statistical (software) packages.


## 2.7. Ethical Considerations

The protocol for the EDHS was approved by the Ethiopia Health and Nutrition Research Institute Review Board, National Research Ethics Review Committee (NRERC) at the Federal Democratic Republic of Ethiopia Ministry of Science and Technology, the Institutional Review Board of ICF Macro, and the Centers for Disease Control and Prevention (CDC) in Atlanta.


## 3. Results

The results of the analysis were divided into four sections: descriptive analysis of survival data results, result of log-rank result, univariable analysis results, and result of multivariable analysis.


### 3.1. Descriptive Analysis

The total numbers of live births considered for this study were 2097 with 366 deaths occurring before the age of 5 years. Of the total live births, 17.5% and 17.4% of under-five deaths have occurred for males and females, respectively. Regarding mothers’ age at birth, 43.4% of children were from mothers of age less than 16 years, out of whom 18.5% died before the age of five years, while the remaining 54.6% were from mothers aged 17 years and above, out of whom 16.6% have died before the age of five years. The under-five mortality was 18.6% and 13.5% for children whose mothers have no education and primary and above education, respectively. Almost two-thirds (65.3%) of the children were born to mothers resident in rural areas, with 18.3% dying before their fifth birthday. Of the 421 children born to mothers resident in urban areas, 14.0% died before their fifth birthday. Of the total of 2097 children, 44.4% were breastfed. Among the mothers, 79.6% were married. There were 46.8% households of size 1–3 members, 46.2% had household size of 4–6, and 7.0% of the households had more than 6 members. In addition, 18.6% of the households had pipe home water while 81.4% used water from unprotected source. Finally, children with preceding birth interval shorter than 2 years were subject to higher risk of under-five mortality (26%). All the results have been summarized in Table2.Table 2
Summary of some important socioeconomic, demographic, and environmental characteristics of children in four selected regions of Ethiopia, 2011.
Covariates Category Censored Death Death percent Total Child’s sex 1 (male) 869 184 17.5 1053 2 (female) 862 182 17.4 1044 Mother’s age at first birth 0 (≤16) 775 176 18.5 951 1 (>16) 956 190 16.6 1146 Breastfeeding status 0 (no) 932 233 20.0 1165 1 (yes) 799 133 14.3 932 Mother’s education 0 (no education) 1314 301 18.6 1615 1 (primary and above) 417 65 13.5 482 Father’s education 0 (no education) 1000 227 18.5 1227 1 (primary and above) 731 139 16.0 870 Marital status 0 (married) 1670 349 17.3 2019 1 (others) 61 17 22.0 78 Preceding birth interval 0 (≤2 years) 574 204 26.0 778 1 (2-3 years) 535 103 16.0 638 2 (≥3 years) 622 59 9.0 681 Area of residence 1 (urban) 362 59 14.0 421 2 (rural) 1369 307 18.3 1676 Type of birth 0 (single birth) 1668 329 16.5 1997 1 (multiple births) 63 37 37.0 100 Income of mother 0 (more than husband) 291 76 21.0 367 1 (less than husband) 1440 290 17.0 1730 Source of drinking water 0 (pipe) 344 46 12.0 390 1 (others) 1387 320 18.7 1707 Family size 0 (1–3) 852 130 13.2 982 1 (4–6) 775 193 19.9 968 2 (≥7) 104 43 29.2 147The plot of overall Kaplan–Meier estimate indicated that, for children who were born in the four selected regions of Ethiopia, under-five death relatively decreased as follow-up time increased (Figure1).Figure 1
Overall product limit estimate of survival function.The log-rank test was performed to see whether there is a significant difference among survival experiences of two or more groups of the covariates (Table3).Table 3
Result of log-rank test of equality of survival distribution for the different categorical covariates.
Covariates Chi-square df p value Preceding birth interval 72.531 2 0.000 Family size 31.205 2 0.000 Type of birth 38.874 1 0.000 Breastfeeding status 10.719 1 0.001 Source of drinking water 9.445 1 0.002 Mother’s education 6.185 1 0.013 Income of mother 3.989 1 0.046 Area of residence 3.243 1 0.072 Father’s education 2.017 1 0.156 Marital status 1.644 1 0.200 Mother’s age at first birth 1.598 1 0.206 Sex of child 0.001 1 0.972From Table3, we can see that the covariates, namely, preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, mothers’ educational level, and income of mothers, exhibit a significant difference in the survival experience among their categories at the 5% level of significance; that is, the hazard of child mortality for these covariates varies significantly from group to group.


### 3.2. Bivariate Analyses

We start with fitting univariable Cox proportional hazards regression model. Table4 displays summarized result obtained from SAS and SPSS output of univariable analysis.Table 4
Results of the univariable proportional hazards Cox regression model.
Covariates B SE Waldχ2 df Sig. exp ⁡ ( B ) LRχ2 Sig. - 2 log ⁡ L PBITVAL (≤2 years)   64.519 2 0.000  65.9208 <.0001 5275.450 2-3 years −0.491 0.121 16.470 1 0.000 0.612 ≥3 years −1.150 0.148 60.516 1 0.000 0.317 FSIZE (1–3)   29.093 2 0.000  29.1003 <.0001 5319.890 4–6 0.437 0.113 14.837 1 0.000 1.548 ≥7 0.874 0.176 24.688 1 0.000 2.397 BTYPE (single birth) 1.019 0.174 34.418 1 0.000 2.770 34.4193 <.0001 5321.649 BFDINGS (yes) 0.348 0.109 10.251 1 0.001 1.416 10.2506 0.0014 5337.582 SDWTR (pipe) 0.472 0.158 8.958 1 0.003 1.603 8.9579 0.0028 5338.051 MEDU (primary and above) 0.333 0.137 5.920 1 0.015 1.395 5.9110 0.0150 5341.767 MINCOM (more than husband) −0.252 0.129 3.834 1 0.050 1.287 3.8381 0.0501 5344.469 ARSID (urban) 0.251 0.142 3.117 1 0.077 1.285 3.1141 0.0776 5344.819 FEDU (primary and above) 0.150 0.108 1.944 1 0.163 1.162 1.9443 0.1632 5346.149 PBITVAL: preceding birth interval; FSIZE: family size; BTYPE: type of birth; BFDINGS: breastfeeding status; SDWTR: source of drinking water; MEDU: mother’s education; MINCOM: income of mother; ARISD: area of residence; FEDU: father’s education.From Table4, we can identify candidate covariates to be considered for the multivariable model. Inclusion of covariates was based on a significant reduction in the value of -2log⁡L^. The value of -2log⁡L^ for the null model is 5348.115. Including preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, and mothers’ educational level in the model, one at a time, resulted in a significant reduction in -2log⁡L^ using the chi-square test. Also, the covariates income of mothers, area of residence, and fathers’ educational level are significant at the 20% level of significance. Hence, all these covariates were considered in the multivariable Cox regression model. We then applied stepwise variable selection procedure to obtain the reduced model. All are presented in Table 5.Table 5
Parameter estimates of the final model.
Covariates B SE Waldχ2 df Sig. exp ⁡ ( B ) LRχ2 S i g . 95% CI forexp⁡(B) Lower Upper PBITVAL (≤2 years)   67.192 2 0.000  68.338 <.0001 2-3 years −0.499 0.121 16.958 1 0.000 0.607   2.435 4.358 ≥3 years −1.181 0.149 63.226 1 0.000 0.307   1.436 2.726 FSIZE (1–3)   33.005 2 0.000  33.491 <.0001 4–6 0.926 0.184 25.326 1 0.000 1.715   1.361 2.162 ≥7 0.540 0.118 20.882 1 0.000 2.524   1.760 3.620 BTYPE (single birth) −1.067 0.176 36.894 1 0.000 2.907 37.054 <.0001 2.060 4.102 BFDINGS (yes) 0.227 0.113 4.013 1 0.045 1.255 12.212 0.0005 1.005 1.567 SDWTR (pipe) −0.546 0.159 11.797 1 0.001 1.727 7.107 0.0077 1.264 2.358 MINCOM (more than husband) 0.364 0.133 7.518 1 0.006 1.439 4.124 0.0423 1.109 1.866Preceding birth interval has a significant negative association with under-five mortality. Children born 2-3 years and more than 3 years after the previous birth have a reduced risk of child mortality by 39 and 69 percent, respectively, relative to children born less than 2 years after the previous birth.Mortality risk of child increased as size of family increases. The risk of dying for a child born in a family of size 4–6 was higher by 71.5% relative to those born in a family with size of 1–3 (reference category). Children born in a family with size of seven and above have a significantly higher hazard ratio than children born in a family with size of 1–3; that is, children born in a family of size seven and above were 152.4% more likely to die before the age of five as compared with children in the reference category.Type of birth (single versus multiple) was also a significant predictor of under-five mortality. Children of multiple births were 190.7% more likely to die before the age of 5 relative to the reference group of single birth (HR = 2.907, 95% CI: 2.060–4.102,p=0.000).Children who were not breastfed were 25.5% more likely to die before their fifth birthday.The risk of dying for a child born in a family without access to pipe drinking water was higher by 72.7% relative to those born in a family with access to pipe drinking water.The risk of under-five mortality for a child whose mother earns less than her husband was higher by 43.9% relative to a child whose mother earns more than her husband (reference category) (HR = 1.439, 95% CI: 1.109–1.866,p=0.006).


## 3.1. Descriptive Analysis

The total numbers of live births considered for this study were 2097 with 366 deaths occurring before the age of 5 years. Of the total live births, 17.5% and 17.4% of under-five deaths have occurred for males and females, respectively. Regarding mothers’ age at birth, 43.4% of children were from mothers of age less than 16 years, out of whom 18.5% died before the age of five years, while the remaining 54.6% were from mothers aged 17 years and above, out of whom 16.6% have died before the age of five years. The under-five mortality was 18.6% and 13.5% for children whose mothers have no education and primary and above education, respectively. Almost two-thirds (65.3%) of the children were born to mothers resident in rural areas, with 18.3% dying before their fifth birthday. Of the 421 children born to mothers resident in urban areas, 14.0% died before their fifth birthday. Of the total of 2097 children, 44.4% were breastfed. Among the mothers, 79.6% were married. There were 46.8% households of size 1–3 members, 46.2% had household size of 4–6, and 7.0% of the households had more than 6 members. In addition, 18.6% of the households had pipe home water while 81.4% used water from unprotected source. Finally, children with preceding birth interval shorter than 2 years were subject to higher risk of under-five mortality (26%). All the results have been summarized in Table2.Table 2
Summary of some important socioeconomic, demographic, and environmental characteristics of children in four selected regions of Ethiopia, 2011.
Covariates Category Censored Death Death percent Total Child’s sex 1 (male) 869 184 17.5 1053 2 (female) 862 182 17.4 1044 Mother’s age at first birth 0 (≤16) 775 176 18.5 951 1 (>16) 956 190 16.6 1146 Breastfeeding status 0 (no) 932 233 20.0 1165 1 (yes) 799 133 14.3 932 Mother’s education 0 (no education) 1314 301 18.6 1615 1 (primary and above) 417 65 13.5 482 Father’s education 0 (no education) 1000 227 18.5 1227 1 (primary and above) 731 139 16.0 870 Marital status 0 (married) 1670 349 17.3 2019 1 (others) 61 17 22.0 78 Preceding birth interval 0 (≤2 years) 574 204 26.0 778 1 (2-3 years) 535 103 16.0 638 2 (≥3 years) 622 59 9.0 681 Area of residence 1 (urban) 362 59 14.0 421 2 (rural) 1369 307 18.3 1676 Type of birth 0 (single birth) 1668 329 16.5 1997 1 (multiple births) 63 37 37.0 100 Income of mother 0 (more than husband) 291 76 21.0 367 1 (less than husband) 1440 290 17.0 1730 Source of drinking water 0 (pipe) 344 46 12.0 390 1 (others) 1387 320 18.7 1707 Family size 0 (1–3) 852 130 13.2 982 1 (4–6) 775 193 19.9 968 2 (≥7) 104 43 29.2 147The plot of overall Kaplan–Meier estimate indicated that, for children who were born in the four selected regions of Ethiopia, under-five death relatively decreased as follow-up time increased (Figure1).Figure 1
Overall product limit estimate of survival function.The log-rank test was performed to see whether there is a significant difference among survival experiences of two or more groups of the covariates (Table3).Table 3
Result of log-rank test of equality of survival distribution for the different categorical covariates.
Covariates Chi-square df p value Preceding birth interval 72.531 2 0.000 Family size 31.205 2 0.000 Type of birth 38.874 1 0.000 Breastfeeding status 10.719 1 0.001 Source of drinking water 9.445 1 0.002 Mother’s education 6.185 1 0.013 Income of mother 3.989 1 0.046 Area of residence 3.243 1 0.072 Father’s education 2.017 1 0.156 Marital status 1.644 1 0.200 Mother’s age at first birth 1.598 1 0.206 Sex of child 0.001 1 0.972From Table3, we can see that the covariates, namely, preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, mothers’ educational level, and income of mothers, exhibit a significant difference in the survival experience among their categories at the 5% level of significance; that is, the hazard of child mortality for these covariates varies significantly from group to group.


## 3.2. Bivariate Analyses

We start with fitting univariable Cox proportional hazards regression model. Table4 displays summarized result obtained from SAS and SPSS output of univariable analysis.Table 4
Results of the univariable proportional hazards Cox regression model.
Covariates B SE Waldχ2 df Sig. exp ⁡ ( B ) LRχ2 Sig. - 2 log ⁡ L PBITVAL (≤2 years)   64.519 2 0.000  65.9208 <.0001 5275.450 2-3 years −0.491 0.121 16.470 1 0.000 0.612 ≥3 years −1.150 0.148 60.516 1 0.000 0.317 FSIZE (1–3)   29.093 2 0.000  29.1003 <.0001 5319.890 4–6 0.437 0.113 14.837 1 0.000 1.548 ≥7 0.874 0.176 24.688 1 0.000 2.397 BTYPE (single birth) 1.019 0.174 34.418 1 0.000 2.770 34.4193 <.0001 5321.649 BFDINGS (yes) 0.348 0.109 10.251 1 0.001 1.416 10.2506 0.0014 5337.582 SDWTR (pipe) 0.472 0.158 8.958 1 0.003 1.603 8.9579 0.0028 5338.051 MEDU (primary and above) 0.333 0.137 5.920 1 0.015 1.395 5.9110 0.0150 5341.767 MINCOM (more than husband) −0.252 0.129 3.834 1 0.050 1.287 3.8381 0.0501 5344.469 ARSID (urban) 0.251 0.142 3.117 1 0.077 1.285 3.1141 0.0776 5344.819 FEDU (primary and above) 0.150 0.108 1.944 1 0.163 1.162 1.9443 0.1632 5346.149 PBITVAL: preceding birth interval; FSIZE: family size; BTYPE: type of birth; BFDINGS: breastfeeding status; SDWTR: source of drinking water; MEDU: mother’s education; MINCOM: income of mother; ARISD: area of residence; FEDU: father’s education.From Table4, we can identify candidate covariates to be considered for the multivariable model. Inclusion of covariates was based on a significant reduction in the value of -2log⁡L^. The value of -2log⁡L^ for the null model is 5348.115. Including preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, and mothers’ educational level in the model, one at a time, resulted in a significant reduction in -2log⁡L^ using the chi-square test. Also, the covariates income of mothers, area of residence, and fathers’ educational level are significant at the 20% level of significance. Hence, all these covariates were considered in the multivariable Cox regression model. We then applied stepwise variable selection procedure to obtain the reduced model. All are presented in Table 5.Table 5
Parameter estimates of the final model.
Covariates B SE Waldχ2 df Sig. exp ⁡ ( B ) LRχ2 S i g . 95% CI forexp⁡(B) Lower Upper PBITVAL (≤2 years)   67.192 2 0.000  68.338 <.0001 2-3 years −0.499 0.121 16.958 1 0.000 0.607   2.435 4.358 ≥3 years −1.181 0.149 63.226 1 0.000 0.307   1.436 2.726 FSIZE (1–3)   33.005 2 0.000  33.491 <.0001 4–6 0.926 0.184 25.326 1 0.000 1.715   1.361 2.162 ≥7 0.540 0.118 20.882 1 0.000 2.524   1.760 3.620 BTYPE (single birth) −1.067 0.176 36.894 1 0.000 2.907 37.054 <.0001 2.060 4.102 BFDINGS (yes) 0.227 0.113 4.013 1 0.045 1.255 12.212 0.0005 1.005 1.567 SDWTR (pipe) −0.546 0.159 11.797 1 0.001 1.727 7.107 0.0077 1.264 2.358 MINCOM (more than husband) 0.364 0.133 7.518 1 0.006 1.439 4.124 0.0423 1.109 1.866Preceding birth interval has a significant negative association with under-five mortality. Children born 2-3 years and more than 3 years after the previous birth have a reduced risk of child mortality by 39 and 69 percent, respectively, relative to children born less than 2 years after the previous birth.Mortality risk of child increased as size of family increases. The risk of dying for a child born in a family of size 4–6 was higher by 71.5% relative to those born in a family with size of 1–3 (reference category). Children born in a family with size of seven and above have a significantly higher hazard ratio than children born in a family with size of 1–3; that is, children born in a family of size seven and above were 152.4% more likely to die before the age of five as compared with children in the reference category.Type of birth (single versus multiple) was also a significant predictor of under-five mortality. Children of multiple births were 190.7% more likely to die before the age of 5 relative to the reference group of single birth (HR = 2.907, 95% CI: 2.060–4.102,p=0.000).Children who were not breastfed were 25.5% more likely to die before their fifth birthday.The risk of dying for a child born in a family without access to pipe drinking water was higher by 72.7% relative to those born in a family with access to pipe drinking water.The risk of under-five mortality for a child whose mother earns less than her husband was higher by 43.9% relative to a child whose mother earns more than her husband (reference category) (HR = 1.439, 95% CI: 1.109–1.866,p=0.006).


## 4. Discussion

In this study, the covariates, namely, preceding birth interval, family size, birth type, breastfeeding status, source of drinking water, mother education, mother income, area of residence, and father education, are significantly associated with under-five mortality in univariable analysis but in multivariable analysis we obtained six factors, namely, preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, and income of mothers, to significantly affect the survival of under-five children.The result of this study shows that preceding birth interval has a negative association with under-five mortality. A study in Ethiopia showed that children born after 18–23, 24–35, 36–47, and more than 47 months of the preceding birth intervals have lower risk of child mortality by 49, 78, 79, and 89 percent, relative to children born after less than 18 months, respectively [16]. A similar study based on DHS data from Bolivia, Guatemala, and Peru suggested that under-five mortality in children born after birth intervals of 24–29 months was higher by 70–90% than in children born after intervals of 36–41 months [17]. In Bangladesh, a study showed that if all birth intervals were between 3 and 5 years long, early neonatal mortality would fall by 5.8%, late neonatal mortality by 4%, postneonatal mortality by 7.6%, and mortality in the 1–4-year age group by 8.7% [18]. This may be due to the fact that shorter birth intervals are associated with maternal nutritional depletion, particularly folate deficiency.There is a higher under-five death among children who were not breastfed than those breastfed. A study conducted in Kenya showed that children who were breastfed for more than 6 months have significantly lower probability (p<0.05) of mortality compared to children breastfed for less than 6 months [10]. Also, in Bangladesh, a study revealed that the duration of breastfeeding was an important determinant of childhood mortality [19]. This may be due to the fact that antimicrobial and anti-inflammatory factors in breast milk provide protection from infection.The findings of this study also revealed that family size was a significant determinant of under-five mortality. As expected, the number of family members increased the under-five death rate; that is, the risk of dying for a child born in a family of size 4–6 is higher by 71% relative to those born in a family with size of 1–3. Contrarily, the study by Desta carried out in Ethiopia found an inverse relationship between under-five mortality and family size [16]. This discrepancy could be due to the time gap between the current study and the study conducted by Desta [16].The result also showed that multiple birth type was a significant factor for under-five death in four selected regions in Ethiopia. Children of multiple births were 2.907 more likely to die before the age of 5 as compared with single birth. In Ethiopia, a study by Desta found multiple births to be a significant determinant factor [16]. A study carried out by Kembo and Van Ginneken in Zimbabwe also found multiple births as a determinant factor of under-five mortality [20].This study showed that the source of drinking water was significant. A child born in a family without access to pipe drinking water was highly exposed to under-five death. In Kenya, a study by Mutunga found source of drinking water to be a determinant factor [21]. A study in China showed that access to safe water reduced child mortality risks by about 34% in rural areas [22]. This may explain why children exposed to water sources that are more likely to be contaminated such as river water are more likely to have diarrheal diseases.This study revealed that the risk of under-five mortality for a child whose mother earns less than her husband is higher as compared with those who earn more. This could be due to the fact that mothers who earn more have the chance to spend money any time they wish without waiting for their husbands to provide care for their child. In Bangladesh, a study by Abir et al. found income of mother to be a determinant factor [23].In every country studied and regardless of the period under consideration, mothers’ education turned out to be one of the main determinants of the mortality of children aged from 1 to 5 years. Findings from [24] suggested that education in general, and female education in particular, exerts a great influence on children’s health and survival with regard to pregnancy, childbirth, immunization, and management of childhood diseases. Mothers’ educational level increases their skills in healthcare practices related to disease treatment, preventive care, hygiene, and nutrition, thus improving chances for child survival. A study in Kenya showed that deaths among under-five children differed significantly with the level of maternal education in rural areas compared with urban areas (p<0.001) [21]. In addition, other studies [20–22] revealed that women with low educational level have high rates of infant and child mortality and those with a few years of schooling have lower infant and child mortality rates.In conclusion, the finding of this study agreed, to a great extent, with the finding of the studies discussed above. However, in this study, mother’s educational level was not found to be a determinant factor, a result that was not in line with other studies [17, 24–27]. Moreover, the finding discussed above about family size is opposite to Desta's finding [16]. This discrepancy could be due to the time gap between the current study and the study conducted by Desta [16].This study was conducted based on 2011 EDHS data. The data is large, nationally representative sample of all deaths based on household interviews with families. The study results reflect the whole of the selected regions. Despite these strengths, a number of weaknesses were also present in this study. The birth history section of 2011 EDHS begins with questions about the respondent’s experience with childbearing (i.e., the number of sons and daughters living with the mother, the number who live elsewhere, and the number who have died). Hence, 2011 EDHS was subject to possible data collection errors (e.g., only surviving women aged 15–49 were interviewed); therefore, no data were available for children of women who had died. Respondents were likely to forget events that occurred in the past. Also, causal effects could not be measured because the study was based on a retrospective cross-sectional study.We recommended that further investigation has to be done based on the 2016/2017 EDHS in order to make the finding of this research more strong.


## 5. Conclusions

Our analysis of determinants of under-five mortality in four selected regions of Ethiopia revealed that preceding birth interval, family size, type of birth, breastfeeding status, source of drinking water, and income of mothers were the significant determinants. However, mothers’ education and mothers’ age at birth were found to be insignificant factors of under-five morality in these regions, a result which is not in line with the literature. In this study, this could be because the majority (77.01%) of mothers involved had no education.



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*Source: 1602761-2016-12-08.xml*