# Prevalence of Erectile Dysfunction and Associated Factors among Hypertensive Patients Attending Governmental Health Institutions in Gondar City, Northwest Ethiopia: A Cross-Sectional Study

Authors: Deribew Abebaw Abuhay; Yibeltal Yismaw Gela; Ayechew Adera Getu
Journal: International Journal of Hypertension
 (2021)

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## Abstract

Introduction. Erectile dysfunction is a common sexual problem affecting men with hypertension. It may result in withdrawal from sexual engagement, decreased work productivity, psychosocial problems including poor self-esteem and depression, and reduction in quality of life for both the affected men and their female partners. Objective. This study was aimed to determine the prevalence of erectile dysfunction and associated factors among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia. Materials and Methods. An institutional-based cross-sectional study was conducted on 423 hypertensive men randomly selected using a systematic random sampling technique. Erectile dysfunction was assessed using the International Index of Erectile Function-5 tool. Sociodemographic, clinical, and behavioral factors were also collected using pretested interviewer-administered questionnaires. Data were entered into EpiData version 4.6 and analyzed using Stata-14. Binary logistic regression was performed to identify factors associated with erectile dysfunction. The level of significance was computed at a p value ≤ 0.05. Results. The mean age of the study participants was 58.84 ± 13.52 years. The prevalence of erectile dysfunction among hypertensive men was 46.34% (95% CI: 41.61, 51.12). About 28% of them had a mild form of erectile dysfunction while nearly 6% had severe forms. Age above 60 years (AOR = 3.8, 95% CI: 1.62, 6.55), stage II hypertension (AOR = 3.5, 95% CI: 1.63, 5.74), hypertension duration >10 years (AOR = 2.5, 95% CI:1.12, 4.19), comorbidity (AOR = 1.7, 95% CI: 1.04, 3.15), depression (AOR = 2.35, 95% CI: 1.31, 4.21), and being physically active (AOR = 0.48, 95% CI: 0.28, 0.83) were factors significantly associated with erectile dysfunction. Conclusion. Nearly half of the study participants had some form of erectile dysfunction, indicating the presence of a high burden of the problem. Assessment of hypertensive men for erectile dysfunction should be part of routine medical care.


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## Body

## 1. Introduction

Sexual dysfunctions are diminished or absent feelings of sexual interest or desire, absent sexual thoughts or fantasies, and a lack of responsive desire [1]. It is a common problem that affects the quality of life of both patients and their sexual partners [2]. Sexual dysfunction in men is categorized based on the sexual response cycle into erectile dysfunction, hypoactive sexual desire, ejaculation disorders, and orgasmic dysfunctions [3].Erectile dysfunction (ED) is defined as the consistent or recurrent inability (of a man) to achieve/maintain a penile erection sufficient for satisfactory sexual performance [4]. ED results in withdrawal from sexual intimacy, decreased work productivity, and reduced quality of life [5,6]. It negatively affects employers as men with ED have higher absenteeism rates due to psychosocial reasons that lead to work productivity impairment [7].The prevalence of ED was different across various parts of the world. ED was found in 66.2% of hypertensive men in Qatar [8], 56.2% of hypertensive patients in Thailand [9], 67% in Israel [10], 61.3% in Bangladesh [11], 35.2% in Greece [12], and 71% in Spain [13]. Moreover, the prevalence of ED was found to be 65.8% in Nigeria [14], 50.6% in Cameroon [15], 43.2% in Egypt [16], and 94.5% in Kenya [17]. Multiple pathogeneses have been identified that link hypertension and ED, including endothelial dysfunction, atherosclerosis, and side effects of antihypertensive medications [18]. Several factors affect erectile function among hypertensive patients, including age, stage, and duration of hypertension, use of antihypertensive medications, depression, and behavioral factors such as excessive alcohol consumption, cigarette smoking, overweight/obesity, and physical inactivity [12,19,20].Despite the fact that this disorder has been present since ancient times, it is in the past few years that sexual medicine has played an important role in putting together a broad overview of ED [21]. There was no study conducted on ED among hypertensive men in Ethiopia. This study was, therefore, conducted to determine the prevalence of ED and identify associated factors among hypertensive patients attending governmental health institutions in Gondar city.


## 2. Materials and Methods

### 2.1. Study Design, Area, and Period

An Institutional-based cross-sectional study was conducted from April 10 to May 20, 2021, in Gondar city located 727 km away from Addis Ababa, the capital city of Ethiopia. The city is among the ancient and densely populated cities in Ethiopia, having 206,987 people, according to the 2007 Ethiopian Central Statistical Agency office report [22]. There are eight governmental health institutions, namely, University of Gondar Comprehensive Specialized Hospital (UoG CSH), Gondar Health Center, Woleka Health Center, Gebriel Health Center, Maraki Health Center, Mintiwab Health Center, Azezo Health Center, and Teda Health Center that have chronic care units for the diagnosis and treatment of chronic diseases such as hypertension and diabetes mellitus.


### 2.2. Source and Study Populations

#### 2.2.1. Source Population

The source population constitutes all male hypertensive patients on follow-up at chronic care outpatient units of governmental health institutions in Gondar city.


#### 2.2.2. Study Population

Male hypertensive patients were on follow-up at selected governmental health institutions of Gondar city during the period of data collection.


#### 2.2.3. Inclusion Criteria

Male hypertensive patients aged 18 years or above and engaged in sexual activity over the past three months prior to the data collection.


#### 2.2.4. Exclusion Criteria

Male hypertensive patients with a history of pelvic and spinal cord injury, past penile/urethral and prostate surgery, and hearing problems were excluded from the study.


#### 2.2.5. Sample Size Determination

The minimum number of samples required for this study was determined using a single population proportion formula by considering the proportion of ED as 0.5 (since no previous study has been conducted), 95% confidence interval, and 5% marginal error (d):(1)n=Zα/22P1−Pd2,where Z is statistics at 95% CI = 1.96, p is population proportion, and d is margin of error:(2)n=1.9620.50.50.05.After adding a 10% nonresponse rate, the total sample size was 423.


#### 2.2.6. Sampling Procedure

Both simple and systematic random sampling techniques were employed to select study participants. Among the eight health institutions, four (University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center) were selected using the lottery method. On average, the total number of male hypertensive patients attending the selected health institutions in a month was 480, 160, 120, and 120, respectively. Using the proportional allocation technique,ni= (n/N)∗Ni, where ni is the number of samples for each study area, N = total number of patients, and Ni = total number of patients in each study area. As a result, 231, 76, 58, and 58 study participants were selected from the University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center, respectively.Each sample from the study area was selected by using a systematic random sampling technique where the sampling interval (k) was obtained by dividing the total number of patients at each health institution by the total sample size. As a result, K = 880/423 = 2. Therefore, every other study participant was interviewed, and the first patient to be included in the sample was chosen randomly by the lottery method:Study variables.Dependent variable.Erectile dysfunction (yes/no).Independent variables.Sociodemographic factors: age, marital status, residence, educational level, occupation, and income.Clinical factors: severity of hypertension, duration of hypertension and antihypertension medications, comorbid diseases (diabetes, cardiovascular diseases, chronic kidney disease), depression, overweight.Behavioral factors: physical activity, alcohol use, cigarette smoking, khat chewing.Operational definitions.Hypertension: based on the eighth Joint National Committee guideline (JNC-8), SBP/DBP of 140/90–159/99 and ≥ 160/100 mmHg for all male hypertensive patients with antihypertensive medications was stage I and II hypertension, respectively, while SBP/DBP of <140/90 mmHg was regarded as controlled [23].Erectile dysfunction: hypertensive patients who scored 6–25 out of 30 points were reported as having ED according to the International Index of Erectile Function (IIEF-5) [24].group of disorders of the heart and blood vessels including coronary heart disease, cerebrovascular disease, peripheral arterial disease, congenital heart disease, rheumatic heart disease, deep vein thrombosis and pulmonary embolism [25].Body Mass Index (BMI): hypertensive patients were underweight for BMI<18.5 kg/m2 and normal for those with BMI ranging from 18.5 to 24.9 kg/m2. Study Cardiovascular diseases: participants were considered overweight for BMI ≥25 kg/m2 [26].Depression: patients who scored ≥10 out of 27 points from the Patient Health Questionnaire-9 (PHQ-9) were considered as having depression while a score of 0–9 was classified as having no depression [27].Physical activity: hypertensive man was considered physically active when engaged in moderate-intensity physical activity for at least 150 minutes per week or in vigorous-intensity physical activity for at least 75 minutes per week, or an equivalent combination of moderate and vigorous-intensity activity [28].Ever alcohol drinker: hypertensive patient who used at least 12 drinks his lifetime [29].Current alcohol drinkers: hypertensive patients had 3 or more standard drinks per week in the last 30 days [29].Former cigarette smokers: a person who has smoked at least 100 cigarettes in his lifetime but who had quit smoking during the time of interview [30].Current smoker: a person who has smoked 100 cigarettes in his lifetime and smokes cigarettes within the last 30 days [30].Ever khat chewer: study participant who chewed khat at least once in his lifetime [31].


### 2.3. Data Collection Tools and Procedures

Two clinical psychologists and three BSc nurses were involved in data collection with close supervision by the investigator. The presence and severity of ED were measured using an interviewer-administered International Index of Erectile Function (IIEF-5) tool; a brief, reliable, and valid questionnaire found useful in the clinical assessment of sexual activities and treatment outcomes in clinical trials. It is composed of six questions (items) answered on five Likert scales summed up to give a total score of 30. Individuals who scored 6–25 out of 30 points were reported as having ED while IIEF-5 scores of 26–30 were reported as not having ED. The severity of ED was classified as mild (17–25 points), moderate (11–16 points), and severe (6–10 points) [32].The weight of the study participants was measured on light cloth and bare feet and recorded in kilograms. Height was measured using a stadiometer to the nearest 0.5 centimeters. The weight measuring scale was checked and adjusted at zero level between each measurement. BMI of study participants was computed by dividing their weight in kilograms by the square of their height in meters and interpreted as underweight (<18.5 kg/m2), normal (18.5–24.9 kg/m2), and overweight (≥25 kg/m2) [26].Blood pressure was measured twice in a sitting position using a standard Mercury sphygmomanometer BP cuff (Mercurial, India) with the appropriate cuff size covering two-thirds of the upper arm after the participant rested for at least five minutes and no smoking or drinking caffeinated beverages for 30 minutes before measurement. The average of two readings taken five minutes apart was recorded as the blood pressure. The staging of hypertension was categorized according to the JNC-8 guideline.The time since hypertension was diagnosed and started taking antihypertensive medications and the presence of comorbidities were taken from the patient’s medical records. Depression status was measured using the PHQ-9 tool designed to evaluate the presence and severity of depressive symptoms over the last two weeks preceding the study. According to this tool, a PHQ-9 score of 0–9 was considered as having no depression while a score of 10 and above was taken as having depression (27).Physical activity was assessed using the global physical activity questionnaire recommended by WHO [33]. Other self-reported behavioral data (alcohol consumption, cigarette smoking, and khat chewing habits) were collected using a standardized questionnaire adopted from World Health Organization (WHO) STEPS surveillance manual [31]. To prevent the spread of COVID-19 during the data collection period, study participants and data collectors applied COVID-19 prevention measures such as wearing face masks and using hand sanitizers.


### 2.4. Data Quality Control and Management

Clinical psychologists and BSC nurses who work in the chronic care units were used as data collectors to decrease nonresponse rates and increase the reliability of results. The questionnaire was pretested on 5% [20] of male hypertensive patients attending their follow-up at Ibex primary hospital, and modifications were made on the basis of the findings. Training and practical demonstrations on interview techniques and measurement procedures were given to data collectors for one day. English version of the questionnaire was translated to Amharic version for consistency. Completeness of the information from questionnaires was checked every day after data collection. Confidentiality of the information was assured from the data collectors and principal investigator side.


### 2.5. Data Analysis

The collected data were coded and entered into EpiData version 4.6 and then exported to Stata-14 for analysis. Descriptive statistics such as frequency, percentage, and other summary statistics were used for describing sociodemographic variables and determining the prevalence of ED. Tables, figures, and texts were used to present the findings. Bivariable logistic regression analysis was applied to identify factors associated with ED. All variables withp value ≤ 0.2 from bivariable logistic regression analysis were entered into the multivariable logistic regression model. The strength of association between dependent and associated factors was determined using the odds ratio with a 95% confidence interval. For all analyses, the statistically significant level was fixed at a p value < 0.05.


### 2.6. Ethical Consideration

Ethical approval was obtained from the ethical review committee of the School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia (Ref. No-433/2021). Permission was obtained from the University of Gondar Comprehensive and Specialized Hospital and the other three health centers. Respondents were informed about the purpose and benefits of the study and gave written consent.


## 2.1. Study Design, Area, and Period

An Institutional-based cross-sectional study was conducted from April 10 to May 20, 2021, in Gondar city located 727 km away from Addis Ababa, the capital city of Ethiopia. The city is among the ancient and densely populated cities in Ethiopia, having 206,987 people, according to the 2007 Ethiopian Central Statistical Agency office report [22]. There are eight governmental health institutions, namely, University of Gondar Comprehensive Specialized Hospital (UoG CSH), Gondar Health Center, Woleka Health Center, Gebriel Health Center, Maraki Health Center, Mintiwab Health Center, Azezo Health Center, and Teda Health Center that have chronic care units for the diagnosis and treatment of chronic diseases such as hypertension and diabetes mellitus.


## 2.2. Source and Study Populations

### 2.2.1. Source Population

The source population constitutes all male hypertensive patients on follow-up at chronic care outpatient units of governmental health institutions in Gondar city.


### 2.2.2. Study Population

Male hypertensive patients were on follow-up at selected governmental health institutions of Gondar city during the period of data collection.


### 2.2.3. Inclusion Criteria

Male hypertensive patients aged 18 years or above and engaged in sexual activity over the past three months prior to the data collection.


### 2.2.4. Exclusion Criteria

Male hypertensive patients with a history of pelvic and spinal cord injury, past penile/urethral and prostate surgery, and hearing problems were excluded from the study.


### 2.2.5. Sample Size Determination

The minimum number of samples required for this study was determined using a single population proportion formula by considering the proportion of ED as 0.5 (since no previous study has been conducted), 95% confidence interval, and 5% marginal error (d):(1)n=Zα/22P1−Pd2,where Z is statistics at 95% CI = 1.96, p is population proportion, and d is margin of error:(2)n=1.9620.50.50.05.After adding a 10% nonresponse rate, the total sample size was 423.


### 2.2.6. Sampling Procedure

Both simple and systematic random sampling techniques were employed to select study participants. Among the eight health institutions, four (University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center) were selected using the lottery method. On average, the total number of male hypertensive patients attending the selected health institutions in a month was 480, 160, 120, and 120, respectively. Using the proportional allocation technique,ni= (n/N)∗Ni, where ni is the number of samples for each study area, N = total number of patients, and Ni = total number of patients in each study area. As a result, 231, 76, 58, and 58 study participants were selected from the University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center, respectively.Each sample from the study area was selected by using a systematic random sampling technique where the sampling interval (k) was obtained by dividing the total number of patients at each health institution by the total sample size. As a result, K = 880/423 = 2. Therefore, every other study participant was interviewed, and the first patient to be included in the sample was chosen randomly by the lottery method:Study variables.Dependent variable.Erectile dysfunction (yes/no).Independent variables.Sociodemographic factors: age, marital status, residence, educational level, occupation, and income.Clinical factors: severity of hypertension, duration of hypertension and antihypertension medications, comorbid diseases (diabetes, cardiovascular diseases, chronic kidney disease), depression, overweight.Behavioral factors: physical activity, alcohol use, cigarette smoking, khat chewing.Operational definitions.Hypertension: based on the eighth Joint National Committee guideline (JNC-8), SBP/DBP of 140/90–159/99 and ≥ 160/100 mmHg for all male hypertensive patients with antihypertensive medications was stage I and II hypertension, respectively, while SBP/DBP of <140/90 mmHg was regarded as controlled [23].Erectile dysfunction: hypertensive patients who scored 6–25 out of 30 points were reported as having ED according to the International Index of Erectile Function (IIEF-5) [24].group of disorders of the heart and blood vessels including coronary heart disease, cerebrovascular disease, peripheral arterial disease, congenital heart disease, rheumatic heart disease, deep vein thrombosis and pulmonary embolism [25].Body Mass Index (BMI): hypertensive patients were underweight for BMI<18.5 kg/m2 and normal for those with BMI ranging from 18.5 to 24.9 kg/m2. Study Cardiovascular diseases: participants were considered overweight for BMI ≥25 kg/m2 [26].Depression: patients who scored ≥10 out of 27 points from the Patient Health Questionnaire-9 (PHQ-9) were considered as having depression while a score of 0–9 was classified as having no depression [27].Physical activity: hypertensive man was considered physically active when engaged in moderate-intensity physical activity for at least 150 minutes per week or in vigorous-intensity physical activity for at least 75 minutes per week, or an equivalent combination of moderate and vigorous-intensity activity [28].Ever alcohol drinker: hypertensive patient who used at least 12 drinks his lifetime [29].Current alcohol drinkers: hypertensive patients had 3 or more standard drinks per week in the last 30 days [29].Former cigarette smokers: a person who has smoked at least 100 cigarettes in his lifetime but who had quit smoking during the time of interview [30].Current smoker: a person who has smoked 100 cigarettes in his lifetime and smokes cigarettes within the last 30 days [30].Ever khat chewer: study participant who chewed khat at least once in his lifetime [31].


## 2.2.1. Source Population

The source population constitutes all male hypertensive patients on follow-up at chronic care outpatient units of governmental health institutions in Gondar city.


## 2.2.2. Study Population

Male hypertensive patients were on follow-up at selected governmental health institutions of Gondar city during the period of data collection.


## 2.2.3. Inclusion Criteria

Male hypertensive patients aged 18 years or above and engaged in sexual activity over the past three months prior to the data collection.


## 2.2.4. Exclusion Criteria

Male hypertensive patients with a history of pelvic and spinal cord injury, past penile/urethral and prostate surgery, and hearing problems were excluded from the study.


## 2.2.5. Sample Size Determination

The minimum number of samples required for this study was determined using a single population proportion formula by considering the proportion of ED as 0.5 (since no previous study has been conducted), 95% confidence interval, and 5% marginal error (d):(1)n=Zα/22P1−Pd2,where Z is statistics at 95% CI = 1.96, p is population proportion, and d is margin of error:(2)n=1.9620.50.50.05.After adding a 10% nonresponse rate, the total sample size was 423.


## 2.2.6. Sampling Procedure

Both simple and systematic random sampling techniques were employed to select study participants. Among the eight health institutions, four (University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center) were selected using the lottery method. On average, the total number of male hypertensive patients attending the selected health institutions in a month was 480, 160, 120, and 120, respectively. Using the proportional allocation technique,ni= (n/N)∗Ni, where ni is the number of samples for each study area, N = total number of patients, and Ni = total number of patients in each study area. As a result, 231, 76, 58, and 58 study participants were selected from the University of Gondar Comprehensive Specialized Hospital, Gondar Health Center, Maraki Health Center, and Azezo Health Center, respectively.Each sample from the study area was selected by using a systematic random sampling technique where the sampling interval (k) was obtained by dividing the total number of patients at each health institution by the total sample size. As a result, K = 880/423 = 2. Therefore, every other study participant was interviewed, and the first patient to be included in the sample was chosen randomly by the lottery method:Study variables.Dependent variable.Erectile dysfunction (yes/no).Independent variables.Sociodemographic factors: age, marital status, residence, educational level, occupation, and income.Clinical factors: severity of hypertension, duration of hypertension and antihypertension medications, comorbid diseases (diabetes, cardiovascular diseases, chronic kidney disease), depression, overweight.Behavioral factors: physical activity, alcohol use, cigarette smoking, khat chewing.Operational definitions.Hypertension: based on the eighth Joint National Committee guideline (JNC-8), SBP/DBP of 140/90–159/99 and ≥ 160/100 mmHg for all male hypertensive patients with antihypertensive medications was stage I and II hypertension, respectively, while SBP/DBP of <140/90 mmHg was regarded as controlled [23].Erectile dysfunction: hypertensive patients who scored 6–25 out of 30 points were reported as having ED according to the International Index of Erectile Function (IIEF-5) [24].group of disorders of the heart and blood vessels including coronary heart disease, cerebrovascular disease, peripheral arterial disease, congenital heart disease, rheumatic heart disease, deep vein thrombosis and pulmonary embolism [25].Body Mass Index (BMI): hypertensive patients were underweight for BMI<18.5 kg/m2 and normal for those with BMI ranging from 18.5 to 24.9 kg/m2. Study Cardiovascular diseases: participants were considered overweight for BMI ≥25 kg/m2 [26].Depression: patients who scored ≥10 out of 27 points from the Patient Health Questionnaire-9 (PHQ-9) were considered as having depression while a score of 0–9 was classified as having no depression [27].Physical activity: hypertensive man was considered physically active when engaged in moderate-intensity physical activity for at least 150 minutes per week or in vigorous-intensity physical activity for at least 75 minutes per week, or an equivalent combination of moderate and vigorous-intensity activity [28].Ever alcohol drinker: hypertensive patient who used at least 12 drinks his lifetime [29].Current alcohol drinkers: hypertensive patients had 3 or more standard drinks per week in the last 30 days [29].Former cigarette smokers: a person who has smoked at least 100 cigarettes in his lifetime but who had quit smoking during the time of interview [30].Current smoker: a person who has smoked 100 cigarettes in his lifetime and smokes cigarettes within the last 30 days [30].Ever khat chewer: study participant who chewed khat at least once in his lifetime [31].


## 2.3. Data Collection Tools and Procedures

Two clinical psychologists and three BSc nurses were involved in data collection with close supervision by the investigator. The presence and severity of ED were measured using an interviewer-administered International Index of Erectile Function (IIEF-5) tool; a brief, reliable, and valid questionnaire found useful in the clinical assessment of sexual activities and treatment outcomes in clinical trials. It is composed of six questions (items) answered on five Likert scales summed up to give a total score of 30. Individuals who scored 6–25 out of 30 points were reported as having ED while IIEF-5 scores of 26–30 were reported as not having ED. The severity of ED was classified as mild (17–25 points), moderate (11–16 points), and severe (6–10 points) [32].The weight of the study participants was measured on light cloth and bare feet and recorded in kilograms. Height was measured using a stadiometer to the nearest 0.5 centimeters. The weight measuring scale was checked and adjusted at zero level between each measurement. BMI of study participants was computed by dividing their weight in kilograms by the square of their height in meters and interpreted as underweight (<18.5 kg/m2), normal (18.5–24.9 kg/m2), and overweight (≥25 kg/m2) [26].Blood pressure was measured twice in a sitting position using a standard Mercury sphygmomanometer BP cuff (Mercurial, India) with the appropriate cuff size covering two-thirds of the upper arm after the participant rested for at least five minutes and no smoking or drinking caffeinated beverages for 30 minutes before measurement. The average of two readings taken five minutes apart was recorded as the blood pressure. The staging of hypertension was categorized according to the JNC-8 guideline.The time since hypertension was diagnosed and started taking antihypertensive medications and the presence of comorbidities were taken from the patient’s medical records. Depression status was measured using the PHQ-9 tool designed to evaluate the presence and severity of depressive symptoms over the last two weeks preceding the study. According to this tool, a PHQ-9 score of 0–9 was considered as having no depression while a score of 10 and above was taken as having depression (27).Physical activity was assessed using the global physical activity questionnaire recommended by WHO [33]. Other self-reported behavioral data (alcohol consumption, cigarette smoking, and khat chewing habits) were collected using a standardized questionnaire adopted from World Health Organization (WHO) STEPS surveillance manual [31]. To prevent the spread of COVID-19 during the data collection period, study participants and data collectors applied COVID-19 prevention measures such as wearing face masks and using hand sanitizers.


## 2.4. Data Quality Control and Management

Clinical psychologists and BSC nurses who work in the chronic care units were used as data collectors to decrease nonresponse rates and increase the reliability of results. The questionnaire was pretested on 5% [20] of male hypertensive patients attending their follow-up at Ibex primary hospital, and modifications were made on the basis of the findings. Training and practical demonstrations on interview techniques and measurement procedures were given to data collectors for one day. English version of the questionnaire was translated to Amharic version for consistency. Completeness of the information from questionnaires was checked every day after data collection. Confidentiality of the information was assured from the data collectors and principal investigator side.


## 2.5. Data Analysis

The collected data were coded and entered into EpiData version 4.6 and then exported to Stata-14 for analysis. Descriptive statistics such as frequency, percentage, and other summary statistics were used for describing sociodemographic variables and determining the prevalence of ED. Tables, figures, and texts were used to present the findings. Bivariable logistic regression analysis was applied to identify factors associated with ED. All variables withp value ≤ 0.2 from bivariable logistic regression analysis were entered into the multivariable logistic regression model. The strength of association between dependent and associated factors was determined using the odds ratio with a 95% confidence interval. For all analyses, the statistically significant level was fixed at a p value < 0.05.


## 2.6. Ethical Consideration

Ethical approval was obtained from the ethical review committee of the School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia (Ref. No-433/2021). Permission was obtained from the University of Gondar Comprehensive and Specialized Hospital and the other three health centers. Respondents were informed about the purpose and benefits of the study and gave written consent.


## 3. Results

### 3.1. Sociodemographic Characteristics of Study Participants

A total of 423 male hypertensive patients were involved in the study with a 100% response rate. The mean age of the study participants was 58.84 (±13.52) years, ranging from 26 to 90 years. The majority of the study participants (79.67%) were married (Table1).Table 1
Sociodemographic characteristics of hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Category
Frequency
Percent (%)
Age (years)
18–40
44
10.40
41–60
201
47.52
61–80
151
35.70
Above 80
27
6.38
Marital status
Married
337
79.67
Single
25
5.91
Divorce
30
7.09
Widowed
31
7.33
Religion
Orthodox
330
78.02
Muslim
71
16.78
Protestant
22
5.20
Residence
Urban
370
87.47
Rural
53
12.53
Occupation
Government employee
109
25.77
Merchant
91
21.51
Nongovernment employee
80
18.68
Farmer
53
12.53
Daily labor
9
2.36
Retired
81
19.15
Educational level
Cannot read and write
51
12.06
Can read and write
71
16.78
Primary school
93
21.99
Secondary school
105
24.82
Diploma and above
103
24.35
Monthly income Ethiopian Birr (ETB)
<1000
83
19.62
1000–5000
305
72.11
>5000
35
8.27


### 3.2. Clinical, Anthropometric, and Behavioral Characteristics of Hypertensive Patients

Of the total respondents, 217 (51.30%) and 66 (15.60%) patients had stages I and II of hypertension, respectively. The median duration of hypertension was four years with IQR from 3 months to 16 years. About 16% of the study participants lived with hypertension for more than 10 years. Among hypertensive patients, 52.95% were on polytherapy. A significant proportion of hypertensive patients (34.28%) had coexisting chronic diseases. The most common coexisting disease was diabetes mellitus, which accounted for 41.4%, followed by cardiovascular disease (29.7%). In our study, we found 34.99% prevalence of depression as presented in Table2.Table 2
Clinical, anthropometric, and behavioral characteristics of hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Category
Frequency
Percent
Severity of hypertension
Controlled (<140/90)
140
33.10
Stage I (140–159/90–99)
217
51.30
Stage II (>160/100)
66
15.60
Duration of hypertension and its medications (year)
<5.0
228
53.9
5.0–10.0
129
30.5
>10.0
66
15.6
Antihypertensive medications
Monotherapy
Diuretics
118
27.90
Calcium channel blockers
44
10.40
ACE inhibitor
37
8.75
Polytherapy
224
52.95
Get counseling/treatments for ED
Yes
11
2.6
No
412
97.4
Normal
307
72.58
Overweight
116
27.42
Comorbidities
Yes
145
34.28
No
278
65.72
Comorbidity type
Diabetes mellitus
60
41.38
Cardiovascular diseases
43
29.66
Chronic kidney disease
8
5.52
Combinations
34
23.45
Depression status
Yes
148
34.99
No
275
65.01
Ever alcohol drinker
Yes
320
75.65
No
103
24.35
Current alcohol drinker
Yes
92
28.75
No
228
71.25
Cigarette smoking
Never
351
82.98
Former
52
12.29
Current
20
4.73
Frequency of smoking/week
Every day
4
20
Less than daily
16
80
Ever khat chewer
No
284
67.2
Yes
139
32.8
Physical activity
Yes
229
54.14
No
194
45.86


### 3.3. Prevalence of Erectile Dysfunction among Hypertensive Patients

Based on IIEF-5 scores, the overall prevalence of ED was 46.34% (95% CI: 41.6–51.1). Mild ED was found among 120 (28.37%, 95% CI: 24.26–32.87), moderate from 52 (12.29%, 95% CI: 9.48–15.79), and severe form of ED among 24 (5.68%, 95% CI: 3.83–8.34) study participants (Figure1).Figure 1
Prevalence of erectile dysfunction among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021.Severe and moderate ED was found among 29.6% and 51.85% hypertensive men above 80 years. Similarly, 10.6% and 15.9% hypertensive men aged 61–80 had severe and moderate ED, respectively. Severe ED was not found among those below 61 years (Figure2).Figure 2
Prevalence and severity of erectile dysfunction based on age group of study participants attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).


### 3.4. Factors Associated with Erectile Dysfunction among Hypertensive Patients

In the bivariable logistic regression analysis, independent variables withp value of less than 0.2 were passed to be included in the multivariable logistic regression analysis. Accordingly, age, severity of hypertension, duration of hypertension, polytherapy, presence of comorbidities, depression, and physical activity were statistically associated with ED.Age above 80 years (AOR = 5.29, 95% CI: 3.38–8.07) and 61–80 years (AOR = 3.86, 95% CI: 1.62–6.55), stage I hypertension (AOR = 2.79, 95% CI: 1.51–5.09) and stage II hypertension (AOR = 3.54, 95% CI: 1.63–5.74), duration of hypertension for more than 10 years (AOR = 2.5 95% CI: 1.12–4.19), polytherapy (AOR = 2.06, 95% CI: 1.18–3.37), depression (AOR = 2.37, 95% CI = 1.32–4.26), presence of comorbid diseases (AOR = 1.76, 95%CI = 1.14–3.15), and being physically active (AOR = 0.48 95% CI :0.28–0.83) were factors significantly associated with ED in hypertensive patients (Table3).Table 3
Bivariable and multivariable logistic regression analysis of factors associated with erectile dysfunction among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Erectile dysfunction
Odds ratio (95% CI)
Yes (%)
No (%)
Crude
Adjusted
Age (years)
18–40
4 (9.09)
40 (90.91)
1.00
1.00
41–60
71 (35.3)
130 (64.7)
2.58 (1.92–6.23)
2.12 (0.98–3.57)
61–80
97 (64.3)
54 (35.7)
5.45 (3.93–9.31)
3.86 (1.62–6.55)∗
>80
24 (88.9)
3 (11.1)
8.68 (4.47–12.4)
5.29 (3.38–8.07)∗
Severity of hypertension
Controlled
24 (17.14)
116 (82.86)
1.00
1.00
Stage I
116 (53.46)
101 (46.54)
4.8 (2.92–7.90)
2.78 (1.51–5.09)∗
Stage II
56 (84.85)
10 (15.15)
6.3 (4.16–8.34)
3.54 (1.63–5.74)∗
Duration of hypertension and its medications (years)
<5
59 (25.9)
169 (74.1)
1.00
1.00
5–10
83 (64.3)
46 (35.7)
2.1 (1.2–4.15)
1.8 (0.95–2.5)
>10
54 (81.8)
12 (18.2)
7.1 (5.6–10.7)
2.5 (1.12–4.19)∗
Antihypertensive medications
Polytherapy
147 (65.6)
77 (34.4)
2.11 (1.35–4.78)
2.06 (1.18–3.37)∗
Monotherapy
49 (24.6)
150 (75.4)
1.00
1.00
Anti-HTN medication class
Diuretics
25
93
2.19 (1.72–4.11)
1.27 (0.85–3.42)
Ca2+ CB
11
33
1.25 (1.24–3.61)
1.06 (0.71–2.18)
Diuretic + CaCB
42
47
2.12 (1.76–4.71)
1.14 (0.83–2.94)
Diuretic + BB
45
10
3.77 (1.25–5.86)
1.97 (1.26–3.75)∗
CaCB + ACEI
11
20
2.36 (1.06–5.11)
1.34 (0.76–2.77)
Diuretic + CaCB + BB
36
13
3.88 (1.87–6.20)
2.03 (1.38–3.88)∗
ACE inhibitor
13
24
1.00
1.00
Depression
Yes
113 (76.35)
35 (23.65)
7.47 (4.72–11.80)
2.35 (1.31–4.21)∗
No
83 (30.18)
192 (69.82)
1.00
1.00
BMI
Normal
110 (35.8)
197 (64.2)
1.00
1.00
Overweight
86 (73.15)
30 (26.85)
4.94 (3.04–8.06)
1.85 (0.98–3.5)
Physical activity
Yes
72 (31.4)
157 (68.6)
0.25 (0.16–0.37)
0.48 (0.28–0.83)∗
No
124 (63.9)
70 (36.1)
1.00
1.00
Comorbidity
Yes
97 (66.9)
48 (33.1)
3.6 (2.4–5.6)
1.76 (1.04–3.15)∗
No
99 (35.6)
179 (64.4)
1.00
1.00
Cigarette smoker
Yes
28 (38.9)
44 (61.1)
1.29 (1.41–3.16)
1.15 (0.79–2.25)
No
168 (47.8)
183 (52.2)
1.00
1.00
Occupation
Government employee
31 (28.4)
78 (71.6)
0.49 (0.12–1.97)
0.77 (0.12–5.01)
Merchant
48 (52.7)
43 (47.3)
1.39 (0.35–5.53)
0.91 (0.14–5.73)
Farmer
22 (41.5)
31 (58.5)
0.88 (0.21–3.68)
0.65 (0.09–4.33)
Nongovernment employee
41 (0.51)
39 (0.49)
1.31 (0.33–5.25)
0.89 (0.14–5.65)
Retired
50 (61.7)
31 (38.3)
2.02 (0.50–8.08)
0.39 (0.06–2.58)
Daily labor
4 (44.4)
5 (55.6)
1.00
1.00
Educational level
Can read and write
40 (56.3)
31 (43.7)
1.57 (0.76–3.24)
2.37 (0.84–6.68)
Primary school
48 (51.6)
45 (48.4)
1.29 (0.65–2.57)
2.69 (0.91–7.99)
Secondary school
49 (46.7)
56 (53.3)
1.06 (0.54–2.08)
1.58 (0.54–4.59)
Diploma and above
36 (34.9)
67 (65.1)
0.65 (0.33–1.29)
1.89 (0.61–5.92)
Cannot read and write
23 (45.1)
28 (54.9)
1.00
1.00
CI: confidence interval; BB: beta-blocker; CaCB: calcium channel blocker; ACEI: angiotensin converting enzyme inhibitor.∗P value ≤ 0.05.


## 3.1. Sociodemographic Characteristics of Study Participants

A total of 423 male hypertensive patients were involved in the study with a 100% response rate. The mean age of the study participants was 58.84 (±13.52) years, ranging from 26 to 90 years. The majority of the study participants (79.67%) were married (Table1).Table 1
Sociodemographic characteristics of hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Category
Frequency
Percent (%)
Age (years)
18–40
44
10.40
41–60
201
47.52
61–80
151
35.70
Above 80
27
6.38
Marital status
Married
337
79.67
Single
25
5.91
Divorce
30
7.09
Widowed
31
7.33
Religion
Orthodox
330
78.02
Muslim
71
16.78
Protestant
22
5.20
Residence
Urban
370
87.47
Rural
53
12.53
Occupation
Government employee
109
25.77
Merchant
91
21.51
Nongovernment employee
80
18.68
Farmer
53
12.53
Daily labor
9
2.36
Retired
81
19.15
Educational level
Cannot read and write
51
12.06
Can read and write
71
16.78
Primary school
93
21.99
Secondary school
105
24.82
Diploma and above
103
24.35
Monthly income Ethiopian Birr (ETB)
<1000
83
19.62
1000–5000
305
72.11
>5000
35
8.27


## 3.2. Clinical, Anthropometric, and Behavioral Characteristics of Hypertensive Patients

Of the total respondents, 217 (51.30%) and 66 (15.60%) patients had stages I and II of hypertension, respectively. The median duration of hypertension was four years with IQR from 3 months to 16 years. About 16% of the study participants lived with hypertension for more than 10 years. Among hypertensive patients, 52.95% were on polytherapy. A significant proportion of hypertensive patients (34.28%) had coexisting chronic diseases. The most common coexisting disease was diabetes mellitus, which accounted for 41.4%, followed by cardiovascular disease (29.7%). In our study, we found 34.99% prevalence of depression as presented in Table2.Table 2
Clinical, anthropometric, and behavioral characteristics of hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Category
Frequency
Percent
Severity of hypertension
Controlled (<140/90)
140
33.10
Stage I (140–159/90–99)
217
51.30
Stage II (>160/100)
66
15.60
Duration of hypertension and its medications (year)
<5.0
228
53.9
5.0–10.0
129
30.5
>10.0
66
15.6
Antihypertensive medications
Monotherapy
Diuretics
118
27.90
Calcium channel blockers
44
10.40
ACE inhibitor
37
8.75
Polytherapy
224
52.95
Get counseling/treatments for ED
Yes
11
2.6
No
412
97.4
Normal
307
72.58
Overweight
116
27.42
Comorbidities
Yes
145
34.28
No
278
65.72
Comorbidity type
Diabetes mellitus
60
41.38
Cardiovascular diseases
43
29.66
Chronic kidney disease
8
5.52
Combinations
34
23.45
Depression status
Yes
148
34.99
No
275
65.01
Ever alcohol drinker
Yes
320
75.65
No
103
24.35
Current alcohol drinker
Yes
92
28.75
No
228
71.25
Cigarette smoking
Never
351
82.98
Former
52
12.29
Current
20
4.73
Frequency of smoking/week
Every day
4
20
Less than daily
16
80
Ever khat chewer
No
284
67.2
Yes
139
32.8
Physical activity
Yes
229
54.14
No
194
45.86


## 3.3. Prevalence of Erectile Dysfunction among Hypertensive Patients

Based on IIEF-5 scores, the overall prevalence of ED was 46.34% (95% CI: 41.6–51.1). Mild ED was found among 120 (28.37%, 95% CI: 24.26–32.87), moderate from 52 (12.29%, 95% CI: 9.48–15.79), and severe form of ED among 24 (5.68%, 95% CI: 3.83–8.34) study participants (Figure1).Figure 1
Prevalence of erectile dysfunction among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021.Severe and moderate ED was found among 29.6% and 51.85% hypertensive men above 80 years. Similarly, 10.6% and 15.9% hypertensive men aged 61–80 had severe and moderate ED, respectively. Severe ED was not found among those below 61 years (Figure2).Figure 2
Prevalence and severity of erectile dysfunction based on age group of study participants attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).


## 3.4. Factors Associated with Erectile Dysfunction among Hypertensive Patients

In the bivariable logistic regression analysis, independent variables withp value of less than 0.2 were passed to be included in the multivariable logistic regression analysis. Accordingly, age, severity of hypertension, duration of hypertension, polytherapy, presence of comorbidities, depression, and physical activity were statistically associated with ED.Age above 80 years (AOR = 5.29, 95% CI: 3.38–8.07) and 61–80 years (AOR = 3.86, 95% CI: 1.62–6.55), stage I hypertension (AOR = 2.79, 95% CI: 1.51–5.09) and stage II hypertension (AOR = 3.54, 95% CI: 1.63–5.74), duration of hypertension for more than 10 years (AOR = 2.5 95% CI: 1.12–4.19), polytherapy (AOR = 2.06, 95% CI: 1.18–3.37), depression (AOR = 2.37, 95% CI = 1.32–4.26), presence of comorbid diseases (AOR = 1.76, 95%CI = 1.14–3.15), and being physically active (AOR = 0.48 95% CI :0.28–0.83) were factors significantly associated with ED in hypertensive patients (Table3).Table 3
Bivariable and multivariable logistic regression analysis of factors associated with erectile dysfunction among hypertensive patients attending governmental health institutions in Gondar city, Northwest Ethiopia, 2021 (n = 423).
Variables
Erectile dysfunction
Odds ratio (95% CI)
Yes (%)
No (%)
Crude
Adjusted
Age (years)
18–40
4 (9.09)
40 (90.91)
1.00
1.00
41–60
71 (35.3)
130 (64.7)
2.58 (1.92–6.23)
2.12 (0.98–3.57)
61–80
97 (64.3)
54 (35.7)
5.45 (3.93–9.31)
3.86 (1.62–6.55)∗
>80
24 (88.9)
3 (11.1)
8.68 (4.47–12.4)
5.29 (3.38–8.07)∗
Severity of hypertension
Controlled
24 (17.14)
116 (82.86)
1.00
1.00
Stage I
116 (53.46)
101 (46.54)
4.8 (2.92–7.90)
2.78 (1.51–5.09)∗
Stage II
56 (84.85)
10 (15.15)
6.3 (4.16–8.34)
3.54 (1.63–5.74)∗
Duration of hypertension and its medications (years)
<5
59 (25.9)
169 (74.1)
1.00
1.00
5–10
83 (64.3)
46 (35.7)
2.1 (1.2–4.15)
1.8 (0.95–2.5)
>10
54 (81.8)
12 (18.2)
7.1 (5.6–10.7)
2.5 (1.12–4.19)∗
Antihypertensive medications
Polytherapy
147 (65.6)
77 (34.4)
2.11 (1.35–4.78)
2.06 (1.18–3.37)∗
Monotherapy
49 (24.6)
150 (75.4)
1.00
1.00
Anti-HTN medication class
Diuretics
25
93
2.19 (1.72–4.11)
1.27 (0.85–3.42)
Ca2+ CB
11
33
1.25 (1.24–3.61)
1.06 (0.71–2.18)
Diuretic + CaCB
42
47
2.12 (1.76–4.71)
1.14 (0.83–2.94)
Diuretic + BB
45
10
3.77 (1.25–5.86)
1.97 (1.26–3.75)∗
CaCB + ACEI
11
20
2.36 (1.06–5.11)
1.34 (0.76–2.77)
Diuretic + CaCB + BB
36
13
3.88 (1.87–6.20)
2.03 (1.38–3.88)∗
ACE inhibitor
13
24
1.00
1.00
Depression
Yes
113 (76.35)
35 (23.65)
7.47 (4.72–11.80)
2.35 (1.31–4.21)∗
No
83 (30.18)
192 (69.82)
1.00
1.00
BMI
Normal
110 (35.8)
197 (64.2)
1.00
1.00
Overweight
86 (73.15)
30 (26.85)
4.94 (3.04–8.06)
1.85 (0.98–3.5)
Physical activity
Yes
72 (31.4)
157 (68.6)
0.25 (0.16–0.37)
0.48 (0.28–0.83)∗
No
124 (63.9)
70 (36.1)
1.00
1.00
Comorbidity
Yes
97 (66.9)
48 (33.1)
3.6 (2.4–5.6)
1.76 (1.04–3.15)∗
No
99 (35.6)
179 (64.4)
1.00
1.00
Cigarette smoker
Yes
28 (38.9)
44 (61.1)
1.29 (1.41–3.16)
1.15 (0.79–2.25)
No
168 (47.8)
183 (52.2)
1.00
1.00
Occupation
Government employee
31 (28.4)
78 (71.6)
0.49 (0.12–1.97)
0.77 (0.12–5.01)
Merchant
48 (52.7)
43 (47.3)
1.39 (0.35–5.53)
0.91 (0.14–5.73)
Farmer
22 (41.5)
31 (58.5)
0.88 (0.21–3.68)
0.65 (0.09–4.33)
Nongovernment employee
41 (0.51)
39 (0.49)
1.31 (0.33–5.25)
0.89 (0.14–5.65)
Retired
50 (61.7)
31 (38.3)
2.02 (0.50–8.08)
0.39 (0.06–2.58)
Daily labor
4 (44.4)
5 (55.6)
1.00
1.00
Educational level
Can read and write
40 (56.3)
31 (43.7)
1.57 (0.76–3.24)
2.37 (0.84–6.68)
Primary school
48 (51.6)
45 (48.4)
1.29 (0.65–2.57)
2.69 (0.91–7.99)
Secondary school
49 (46.7)
56 (53.3)
1.06 (0.54–2.08)
1.58 (0.54–4.59)
Diploma and above
36 (34.9)
67 (65.1)
0.65 (0.33–1.29)
1.89 (0.61–5.92)
Cannot read and write
23 (45.1)
28 (54.9)
1.00
1.00
CI: confidence interval; BB: beta-blocker; CaCB: calcium channel blocker; ACEI: angiotensin converting enzyme inhibitor.∗P value ≤ 0.05.


## 4. Discussion

This study aimed to determine the prevalence of ED and associated factors among hypertensive patients who have follow-ups at governmental health institutions in Gondar city. The prevalence of ED in this study was 46.34% (95% CI: 41.6–51.1) which is similar to studies done in Egypt (43.2%) [16] and Cameroon (50.6%) [15]. However, it was lower than those reported from Thailand (56.6%) [9], Qatar (66.2%) [8], Spain (71.0%) [13], and Kenya (94.5%) [17]. This difference might be due to the sociocultural differences, the study design used, and the exclusion criteria. This finding was higher than studies from Greece (35.2%) [12], Israel (21.8%) [34], and Nigeria (41.5%) [35].In this study, age was a significant factor for developing ED. The prevalence of ED increased as the age of study participants increased. These results are similar to those studies from Qatar [8], Thailand [9], Cameroon [15], and Nigeria [14]. Increased age is often accompanied by multiple organic diseases which can interfere with erectile function. In particular, cardiovascular and metabolic diseases with increased prevalence among older ages could play a crucial role in the pathogenesis of age-related ED [36]. Since penile erection is primarily a vascular event, it may be impaired on increasing age that causes degenerative changes in the vascular endothelium resulting in endothelial dysfunction. This in turn resulted in an alteration of vascular tone as a result of a marked reduction of the relaxation process of smooth muscle cells located in the corpus cavernosum and wall of small arteries [21]. Age-related decrease in testosterone levels could also contribute to the increased prevalence of ED [37]. Furthermore, it is recognized that there is aging-dependent decrease in the amount of functioning corporal smooth muscles. The mechanism underlying this aging-related loss of normal smooth muscle within the corporal body is believed to be mainly due to the apoptotic process primarily triggered by oxidative stress [38].The results of this study indicated that male patients with stages I and II of hypertension exhibited ED more frequently than subjects with controlled hypertension. As the severity of hypertension increased, the prevalence of ED also increased, which is consistent with studies from Israel [34], Qatar (66.2%) [8], Greece [12], and Cameroon [15]. Our study also found that patients with hypertension follow-up for long periods were more likely to acquire ED, which is in line with studies in Thailand [9], Greece [12], and Egypt [16]. Since vascular tissue is the main contributor for penile erection, structural/functional abnormalities in penile vessels may impair the ability to achieve and maintain erection [18]. Hypertension is related to endothelial dysfunction leading to reduced nitric oxide (NO) production by the endothelium, which in turn results in ED [39]. Hypertension is also responsible for stenotic lesions secondary to atherosclerosis, smooth muscle hypertrophy of cavernosum arteries, and blood flow impairment in the penile vasculature [21].Treatment with antihypertension medications had increased the prevalence of ED in our study participants. Patients on combination antihypertensive therapy exhibited ED more frequently (64.07%) than patients on monotherapy (25%), and the difference was statistically significant (p<0.05). This finding was in line with studies in Qatar [8] and Cameroon [15], where antihypertensive polytherapy was significantly associated with ED. Combination pharmacotherapy is often prescribed in the treatment of hypertension in the majority of hypertensive patients. ED is considered a common side effect of central-acting beta-blockers and diuretics that reduce cardiac output and blood pressure, thereby decreasing blood flow to penile vasculature [40,41].In the current study, the presence of comorbid medical illnesses such as diabetes mellitus, hypertensive heart disease, and chronic kidney disease increased the prevalence of ED. The prevalence of ED among hypertensive men with no comorbidity was 35.6%, but it was 66.9% among those with comorbidities; and the change was statistically significant which is in agreement with other studies [10,35,42]. Diabetes mellitus was the major comorbid disease found among the study participants. It affects the corpus cavernous nerve terminals and endothelial cells, resulting in a deficiency in NO synthesis and release, which in turn causes ED [43].Moreover, this study found that ED was significantly associated with depression. This finding is supported by studies from Spain [13], China [44], and Finland [45]. Depression affects the higher centers of the brain, which initiate sexual arousal and behavior and interfere with normal erectile neurophysiology [45]. Depressed people have a low degree of sexual appetite because of their feeling of low self-esteem and guilt feeling resulting in ED [45]. However, since the study is cross-sectional, it is difficult to establish the direction of causality.Our study also revealed that the likelihood of developing ED among physically active study participants was reduced by 48% (AOR = 0.48 95% CI: 0.28–0.83). This is in line with other studies where physical activity was statistically associated with ED [8,20,46,47]. The mechanisms by which physical activity reduces the risk of ED include improved cardiovascular fitness, endothelial function, and beneficial effects on self-esteem and mental health with a positive impact on psychological issues associated with sexual function, increase in endothelial-derived NO [48], decrease in oxidative stress [49], and increase in regenerative endothelial progenitor cells [50].Another important finding from this study was that there were a few number of hypertensive men with ED who were approached to get counseling and medications for their sexual problems. Only 11 (2.6%) patients sought medical advice and were taking medications for treatment. This failure to seek medical attention might be due to social stigma or not considering ED as a treatable condition. As a result, ED is a common distressful problem of hypertensive patients, which is often underreported. This could further adversely affect the quality of life of the affected men.


### 4.1. Limitations of the Study

The cross-sectional nature of the study does not allow making inferences about the causal relationship. Further longitudinal studies to clarify the causal relation between ED and those predictors should be conducted. The study may have social desirability bias due to the type of data collection technique (face-to-face interviewer-administered questionnaire).


## 4.1. Limitations of the Study

The cross-sectional nature of the study does not allow making inferences about the causal relationship. Further longitudinal studies to clarify the causal relation between ED and those predictors should be conducted. The study may have social desirability bias due to the type of data collection technique (face-to-face interviewer-administered questionnaire).


## 5. Conclusion

Nearly half of the study participants had erectile dysfunction, indicating the high burden of the problem among hypertensive patients. ED and hypertension were found to be related, as there were more cases of ED among hypertensive men. The prevalence of ED was associated with the age of patients, severity and duration of hypertension, presence of comorbidities, depression, and physical activity. Hypertensive patients with ED were not getting clinical counseling and medical treatment for their sexual problems. Therefore, assessment and management of ED should be part of routine medical care in hypertensive follow-up clinics. In addition, hypertensive patients should adequately control their blood pressure and prevent coexisting illnesses to reduce the risk of ED.



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*Source: 1482500-2021-11-26.xml*