SPARC has been proposed to be an albumin receptor in other epithelial tissues (Swaroop et al., 1988; Kopp et al., 1992; Tiruppathi et al., 1996), and is expressed at higher levels in human fetal tissue than in adult tissue and cell lines (Swaroop et al.

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Additionally, the studies in general point out that the type of transportation seems to be more related to social and environmental factors than to the students’ freedom of choice, as observed in the studies carried out by Davison et al. (2008); Dollman & Lewis (2007); Robertson-Wilson et al.

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This calculation is in accordance with the contributions estimated by Greenwood et al. (1997) and Luttmer (2007).

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For this study we used several Fortran programs that have been taken from the Perfect Benchmarks, RiCEPS (Rice Compiler Evaluation Program Suite), and Genesis benchmark suites [12, 1] as well as from the WIEN95 software package [13].

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2% in those with TB meningitis and TB lymphadenopathy, respectively.(20,22) Of the 17 patients with ocular mycobacterial disease in this study, 13 had active disease limited to the eyes, 2 had systemic lymphadenopathy, 1 had miliary TB, and only 1 had active pulmonary TB.

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In contrast, another transcription factor, SP1, but not NF-kB, is reported to mediate the TNF-a-induced LDL receptor expression and sterol-induced repression of LDL receptor expression (7, 10, 15).

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Geriatric patients are at high risk for PPH in the general population (Jansen and Lipsitz 1995; Mathias 1991).

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False negatives can occur if the object is small or if a hypointense structure or signal void is mistaken for a tendon, dense collagenous structure, or air.(15) Compared with both ultrasound and CT, MRI is the most limited in spatial resolution.

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, 2008; Pesch and Hülskamp, 2011) is an essential feature in all models explaining trichome patterning (Pesch and Hülskamp, 2009; Balkunde et al., 2010; Tominaga-Wada et al., 2011; Grebe, 2012).

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With respect to reading span, two sets of studies (Lustig et al., 2001; May et al., 1999) demonstrated that reducing interference by administering the longest set sizes first rather than last is especially beneficial to older adults.

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…et al. 2000; Hoey et al. 2003; Birkner et al. 2004; Rusu et al. 2005;
Kaushik et al. 2008), mouse (Autrup et al. 1978; Pretlow et al. 1978; Kondo et al. 1984; Kedinger et al. 1986; Fukamachi 1992, Macartney et al. 2000), rabbit (Benya et al. 1991; Hata et al. 1993; Reddy et al. 1996), pig…

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Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].

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Between days 12 and 14 postinoculation, young, cellular fibrous polyps of collagenous tissue can be observed that develop into discrete fibroblastic polyps in the alveolar ducts (20, 21).

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Compounding this limitation, the WSAP did not result in an equal number of data points (i.e., reaction times) for each type of wordsentence pair (Amir et al. 2012; Beard and Amir 2009).

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The high prevalence of extant polyploids suggests that WGD is both a pervasive and contemporary influence in genome evolution (Otto and Whitton 2000; Mable 2004; Otto 2007).

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PASS [18] supports provenance at the system level and is a layer grafted in a file system.

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…(1997) ERK Pathway CGP78850 competes for Grb2-SH2 0.043 30 Gay et al. (1999); de Lamirande and Gagnon (2002)
Sulindac sulphid Ras-Raf Interaction – 100 de Lamirande and Gagnon (2002) ZM336372 Raf, competitive inhibition 0.07– 0.007 3 de Lamirande and Gagnon (2002) PD98059 prevents MEK activation…

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Knowledge of lesions associated with HIV/AIDS was observed to be similar to studies in Brazil (20), but lower than that of the UK and Iran (16,21).

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machine learning approaches (Haghighi and Klein, 2009; Raghunathan et al., 2010).

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edu/eeglab); this procedure was extremely effective in decomposing the signals into multiple statistically independent components, allowing artifacts to be easily detected [47].

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‚Ä¶TB abundances were expressed as total counts and not as CFU counts, but considering that a maximum of 10% of total marine bacteria are cultivable, our results are similar to those reported by Skjermo and Vadstein (1993) and Hach√© and Plante
 (2011) in their commercially enriched rotifer cultures.

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The physical component score (PCS) and mental component score (MCS) from the SF-12 were compared to those obtained from the 1998 National Survey of Functional Health Status.(15) Additionally, an addendum questionnaire (AQ) was administered to LDs after the SF-12 questionnaire.

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Differences may result in part due to the fact that BIOLOG selects for only a portion of the microbial community (Smalla et al., 1998) while PLFA analysis includes the whole microbial community, regardless of activity.

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Our findings further support previous findings on the usefulness of CBT in the non-invasive evaluation of severe chronic liver disease [14,19].

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These results were also found in previous works.(9,11,12) A balanced occlusal arrangement and an adequate interproximal contact were of great importance for the results found in this study and as described by related literature.

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stemmed implants and augments) when revising a failed UKR is extremely variable and ranges from 11% to 76% in the literature and 33% in the present series (3,13,14,19,21,22,24).

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These enzymes have been implicated in pesticide resistance in plants and insects (Sheehan et al., 2001), and
some GST polymorphisms are thought to alter cancer susceptibility in mammals (Hayes and Pulford, 1995).

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Women using the LNG-IUS for contraception experience a change in their menstrual bleeding pattern [1,4].

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The resulting fragments were sequentially cloned into pBluescript SKII+ (Stratagene), cut with XmaI and NotI and ligated into pSB890 [15], yielding suicide plasmid pM1664.

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In order to evaluate the effectiveness and efficiency of OLCS, we compare its performance with CLPSO [23], CMA-ES [24], and GL-25 [25].

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The present observations support and extend earlier contentions that Parkinson patients prefer to adopt a closedloop control mode, adjusting their movements continuously on the basis of available visual information (Flowers 1976).

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This is not a fundamental issue but a technical one and can be accounted for by re-parametrizing synaptic responses in such a way that changes in α (and/or β) do not influence their maximal heights (Hutt and Longtin, 2010).

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These effects are consistent with BCAR3-dependent increase in SRC activity leading to increased BCAR1 downstream signaling as previously reported in cells not treated with antiestrogens (9, 30, 32, 51).

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…shown distractor suppression to have a much larger effect on capacity than target selection processes (Bettencourt & Somers, 2009; Pylyshyn, 2006; Vogel et al., 2005; Zanto & Gazzaley, 2009), and as the effect on capacity of increasing the number of distractors is correlated between VSTM and MOT…

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To minimize the contribution of each individual patient sample to the set of significantly altered genes [51] the statistical analysis has included a leave-one-out crossvalidation procedure; essentially, one sample was removed at a time, and every time a new set of significantly altered genes was determined using the remaining ten samples, ultimately pointing to the most consistently altered gene set, which is common to all leave-one-out sets (see Material and methods for details).

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We generate segments from the MSRA boxes by applying grabcut over the average box annotation, and use these as supervision for the DeepLab model.

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We evaluated 22 prospective cohorts in which HHV-8 DNA quantification had been performed on oropharyngeal swabs, including 18 cohorts from the Virology Research Clinic, University of Washington [14, 28‚Äì32], and 4 studies by affiliated investigators in Lima, Peru [33]; Kampala, Uganda [4]; Mombasa, Kenya [34]; and Yaounde, Cameroon.

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All experiments included blocks of auditory stimuli and blocks of visual stimuli, delivered with different presentation rates (e.g. auditory blocks repetitions and visual blocks repetitions were not the same), in a semi-overlapped manner (Hertz & Amedi, 2010).

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enables early detection of newborns with CAH so that timely and appropriate management is instituted (Padilla and Therrell 2007).

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Feeding Conditions
Our feeding procedure is based on the limited access model described by Corwin et al. (1998), in which non-food-deprived animals with sporadic and limited access to a high-fat food develop binge-type behaviors.

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According to above points we need to have specific rules or formulas by which we easily calculate execution time as well as effort and time at deployment process but before they can guarantee a successful installation, producers must be able to determine what components are available at a given site, as well as the configuration of those components [7].

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The network is based on at least two patterning mechanisms each capable of explaining patterning alone (Pesch and Hülskamp, 2009).

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Drawing from career literature, mentoring is deemed to occur if mentors take an active interest in advancing the salesperson ’ s career by providing developmental assistance ( Higgins and Kram, 2001 ).

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Our results are roughly in line with those of Fukaya et al. (2008) with regard to the cell morphologies.

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Andes have been eroded by the Patagonian ice sheet and are much lower and narrower (Garzione et al. 2008; Hoorn et al. 2010; Lavina & Fauth 2011).

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The largest correlations between the depression ratings and perceived social support were found within the sub-scales of Friends and Family (Clara et al., 2003).

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Moreover, the risk of developing melanoma is greater in males than in females over the age of 40, although the opposite effect is observed in patients under 40 years old (Lens and Dawes, 2004; Jemal et al., 2010).

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The LC microstructure of each eye was automatically segmented using a previously described method with high reproducibility.(13,14) The diameter of LC pores and the thickness of LC beams were defined by the 3D local thickness (Fig.

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Very young (8-10 weeks old) rats were used in this study because it has been shown that younger rats are more sensitive to dietary salt loading than older ones (Dahl et al., 1968; Obiefuna et al., 1991; Sofola et al, 2002).

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This noise stems from pulsatile motion of large arteries in the direct vicinity of the brainstem as well as from the flow of cerebro-spinal fluid (CSF) (Harvey et al., 2008; Klose et al., 2000).

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…replication (Anand et al., 1995), with olomoucine, an inhibitor of cyclin-dependent kinase activity (Glab et al., 1994; Meijer, 1996) and by RNAi (Fire et al., 1998; Tabara et al., 1998; Tabara et al., 1999; Grishok et al., 2000; Klink and Wolniak, 2000; Klink and Wolniak, 2001), using dsRNA…

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The high rate of cardiac and renal dysfunction in critically ill patients limited the discriminative role of BNP, and no BNP value was able to completely rule out the presence of concomitant cardiac dysfunction (7).

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The rate of OJ− # production during reactions in vitro was measured as the superoxide dismutase (SOD)-sensitive rate of cytochrome c reduction (Imlay & Fridovich, 1991) in a Beckman DU 650 spectrophotometer.

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Moreover, variability in analgesic efficacy could be explained by inter-subject variations in plasma levels of parent drug and its active metabolite eventually affected also by co-medications [19], and therefore, dosage must be titrated for optimal effect and avoidance of toxicity after appropriate TDM.

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Approximately 10 days after the completion of the experiments at sea level an arterial blood sample was taken for other purposes [14].

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The proof obligations generated by HIPComp are discharged using off-the-shelf constraint solvers (Omega Calculator [14] and Mona [15]).

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The GITT model performs better than an empirical lag-time model [17], however, its predicted profiles tend to underestimate Cmax, which, if consistent, may suggest confounding systematic bias or invalid assumptions.

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The identified propionylation sites (Okanishi et al. 2014) were approximately as much as that of acetylation in T.

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Similar findings were reported in healthy Italian children between 5 and 19 yr of age (32).

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Therefore, in addition to the provision of care and support in an all-female environment, many authors argue that, to be effective, women-specific services must also adopt approaches to care that are substantially different than the traditional care provided in mixed-gender settings [62,65,68,69,78,79,83,84].

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The 3-step admission system in the Netherlands has been described in more detail in a previous study.[17]

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Our results are partially consistent with the findings of previous works (M‚àö¬∫hi et al., 2014; Zheng et al., 2016).

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Five-microliter yeast cells were spotted onto the interaction selection media (synthetic complete agar-Leu-Trp-His-Ala with 1.5 mM 3-amino-1,2,4-aminotriazole) to score growth as an indicator of protein‚Äìprotein interaction (Lee et al., 2007).

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hGFAP-Cre [19] and MATH1-GFP [20] transgenic animals were kindly provided by Rob Wechsler-Reya at Duke University.

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Evidence for the measurement properties of the I-QoL has been demonstrated by a number of studies [17, 18, 20]; this study represents the largest evaluation in a UK population.

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It is conceivable that low dose dipyridamole might increase coronary flow through collaterals (19,20).

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The CFI estimates the relative fit of the target model in comparison with the baseline model where all variables in the model are uncorrelated (Bentler, 1990; Hu & Bentler, 1995).

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For our experimental evaluation, we used the binary test-datasets of Weber et al. [35] and Batenburg and Sijbers [4].

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, 2016): the Bidirectional Attention Flow model (BiDAF) (Seo et al., 2016) and DrQA (Chen et al.

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Both the methods used in the present work were previously demonstrated to be sufficiently accurate for detecting physiological and pathological changes in serum hepcidin in healthy volunteers and in patients with various disorders of iron homeostasis.(22,7,34,35) Indeed, results with the two methods were essentially concordant from a qualitative point of view, although quantitative differences were observed, e.

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We also evaluated the quality of each study based on the Methodological Evaluation of Observational Research (MORE)- Observational Studies of Incidence or Prevalence of Chronic Diseases developed by the Agency for Healthcare Research and Quality (AHRQ) [14].

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(Note: We are aware of the method [3] which is another variant of 2D FCN and achieved excellent performance on the neuron dataset.

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Randomized controlled trials conducted in a range of surgical settings over the last 25 years have clearly demonstrated that enoxaparin is associated with lower rates of VTE than placebo or elastic compression, without compromising patient safety [5–9].

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Evaluating diverse predictions Where only a single ground truth answer exists, the k-best oracle [11, 23] is a suitable scheme for evaluating diverse predictions.

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In-between methods can be subdivided into linear approximations [12,24] and quadratic interpolation methods [22,23,25–27] based on the degree of the polynomial approximation employed.

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bacterial species can drive major changes in the gut microbiota and, thus, influence the metabolic profile (Marcobal et al., 2013).

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Xu et al [42] observed TF occupancy across the blocus of proerythroblast derived from fetal liver and adult stem cells.

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The well-known tumor suppressor p53 is a transcriptional master regulator that regulates the expression of genes associated with a wide range of functions, including cell-cycle arrest, apoptosis, and senescence in response to genotoxic andnongenotoxic stresses that challenge cellular genomic integrity (1).

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CBP adds to its input layer an extra node having an input of the sum of the squared input components [1, 2].

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reported that low miR-99a expression in hepatocellular carcinoma (HCC) tissues was associated with worse prognosis in HCC patients [10].

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Between 1987 and 1998 the prevalence of FOBT screening increased slightly, while screening rates for endoscopies doubled in the US [35].

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It should be noted that a WURS cut-off score of 46 or higher can discriminate individuals with a history of childhood attention-deficit/ hyperactivity disorder (Kafka & Prentky, 1998; Roy-Byrne et al., 1997; Ward et al., 1993; Wender, 1995).

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This would be in accordance with data showing that the PVN is important for dietary preference for carbohydrates and lesions to the PVN result in increased preference for high fat diets (Aravich and Sclafani, 1983; Leibowitz, 1988; Hoebel et al., 1989).

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Nonetheless, marketed EGFR antibodies have limited potential for development as ADCs because their significant binding to normal tissue causes on-target toxicity (9).

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An interdisciplinary approach has been advocated for in a broad range of healthcare fields, including primary care [1, 2], developmental disability assessment [3], com-

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In addition, G4 DNA could form at telomeres either at the 3’ single strand G-rich overhang (22) or by molecular crowding of duplex DNA (23).

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In Section 2, we present an experiment by Abeler et al. (2010) that analyzes the relative importance of two conflicting fairness principles—wage equality and horizontal equity. In particular, Abeler et al. study whether equal wages are considered fair and look at potentially detrimental consequences of equal wages on performance. In Section 3, we turn to a second question that becomes important when principals interact with more than one agent, namely, whether the principal can observe agents’ individual performance or only the outcomes of the group of agents as a whole. We present a recent study by Kleine and Kube (2010) that addresses the question whether reporting (subjective) performance measures can enhance the efficiency of interaction in work groups. Next, we discuss a study by Schneider and Kube (2006) that analyzes how differences in social proximity affect gift exchange in multi-worker firms.

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Our findings, in accordance with Smith et al. (2004), demonstrate a neuropsychological dissociation between endogenous and exogenous validity effects.

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(2016) demonstrated that blocking MST1/2 kinase activities with a newly identified compound, 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido [5,4-b]thieno[3,2-e][1,4]diazepin-2-l)amino)benzenesulfonamide (XMU-MP-1), has benefits for intestinal and liver repair and regeneration in mice (Fan et al., 2016).

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1996) and then to the effector enzyme, namely phospholipase C-b 2 (PLC-b 2) (Adler et al. 2000).

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Another approach to scaling the PK parameters was a theoretical approach that fixed the allometric exponent to its theoretical values [14].

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Previous research using the WSAP suggests that interpretation biases based on reaction time measures may be different for socially anxious undergraduates than for individuals with SAD (Amir et al. 2012).

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LDL CHD There is strong evidence that genetic variants that increase LDL also proportionately increase risk of CHD (46).

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This method was recently used to estimate cancer incidence in France and China [22, 25] and is frequently used by GLOBOCAN [26].

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Rats were killed after 2.5 min, which was the time found to produce significant AA release mediated by PLA2 activity after in vivo LTP induction (Clements et al., 1991).

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Geographical locales where gonorrhoea incidence was much higher than surrounding areas have been identified as possible ‘core’ populations (Rothenberg 1983; Bernstein et al. 2004).

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…studies found similar results when comparing resisted sprint training with elastic bands (Myer, Ford, Brent, Divine, & Hewett, 2007), weighted-sled (Spinks et al., 2007; West et al., 2012), weighted-vest (Clark et al., 2010; Rey, Padron-Cabo, & Fernandez-Penedo, 2016) with unresisted training on…

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BM3D BRIS- CPBD JNB LPC S3 BIQI Metri- Ours QUE[17] [19] [11] [14] [26] [18] cQ[30]

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Protein extraction, western blots and immunoprecipitations were performed as previously described (Pentimalli et al., 2008).

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…(Trueman et al., 1996); two NADH-NR, NR1 and NR2 (Long et al., 1992); nitrite reductase, NiR (Lahners et al., 1988); glutamate dehydrogenase, GDH1 (Sakakibara et al., 1995); four cytosolic GS, gln1, gln2, gln3, and gln4, plastidic GS, gln5 (Sakakibara et al., 1992a); and asparagine synthetase…

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During phase (1), it looks for hidden correlations among the attribute values and the class attribute in the training data set and generates them as ‘‘Class Association Rule’’ (CARs) in ‘‘If-Then’’ format (Thabtah et al., 2004).

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Many investigations have focused on the evaluation of genotoxicity of pesticides in occupational or environmental settings using different methods (2-12).

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Post-mortem studies have shown that cholinergic markers depletion strongly correlates with symptoms severity in AD (Dournaud et al., 1995; Prohovnik et al., 2006).
ing Laboratory (TNL), McGill alth University Institute, 6875 rdun), QC, Canada H4H 1R3.

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It is likely to be responsible for generating the proton gradient in these organelles detected with MitoLight and Rhodamine 123 staining (Zierdt et al. 1988; Nasirudeen and Tan 2004) and MitoTracker (Hamblin et al. 2008; Stechmann et al. 2008).

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This is closely related to skin pigmentation as melanin has been shown to have a protective function for UV-induced melanoma and Caucasian populations show low levels of melanogenesis (Lens and Dawes, 2004; Hu et al., 2008; Jemal et al., 2010).

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Stimuli surfaces were irregular-shaped wooden boards manually
placed on a metal slope-presentation device that allowed the experimenter to quickly and accurately set the wooden board to a predetermined angle (see Durgin, Li &
Hajnal, 2010; Li and Durgin, 2009).

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These results are consistent with several studies that have suggested that miR-199a-3p is a potential tumor suppressor (24-27).

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The answer to this question is currently unknown, but experimental evidence so far suggests that non-motile mutants are at a severe disadvantage for establishing and maintaining interactions with these hosts (Black et al., 1988; Nachamkin et al., 1993; Wassenaar et al., 1993; Hendrixson and DiRita, 2004; Wösten et al., 2004).

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The importance of these techniques has led to a recent and intensive effort to develop and understand mathematical models for use in analysis of cell proliferation data [6, 12].

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A major drawback with NIFAS was that the applet only showed one simultaneous tree, but in order to analyze the evolution of different domains it is essential to compare their trees visually.

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Intermediate-conductance calcium-activated potassium channels (IK) enhance glioma cell migration induced by chemokines such as CXCL12 (74).

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EOs have proven effective in plant protection against plant chewing and sucking insect pests, as well as flies that oviposit in fruit [4].

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…gametophytes and sporophytes, we conducted a preliminary analysis with all Glomus sequences from
Botrychium (Ophioglossaceae; Kovács et al. 2007; Winther and Friedman 2007), Lycopodiaceae (Winther and Friedman 2008) and Psilotum nudum (Psilotaceae; Winther and Friedman 2009) reported in…

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Moreover, the damp effect introduced by the back-plate will cause acoustic impedance, and to decrease the sensitivity of microphones subsequently [8-9].

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Recently, analyses of archived African desert dust samples collected between 1812 and 1838 by colleagues of Charles Darwin demonstrated concentrations of bacteria and fungi of 104e105 CFU g 1 (Gorbushina et al., 2007).

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The Hill coefficient values (“n”) were also consistent to those of the E. coli expressed P450 3A37 (Rawal et al., 2010b).

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(GC) [23], Seeded Region Growing (SRG) [24], Random Walker (RW) [18], Distance Regularized Level Set (DRLSE) [25], and Laplacian Coordinates (LAP) [26].

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One of the main problems in distributed systems is the deadlock problem [15].

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Although we found manual dissection of BG01 was successful, we adapted this line to trypsin-passaging on feeders and on Matrigel to facilitate comparison with an independently-derived line, HUES-7 (Cowan et al., 2004).

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The saccadic movement can be made by asking the client during the examination (Kuicken et al., 2001-2002; Parker et al., 2009).

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Symptoms of pain and tenderness have been common complaints in the majority of cases resulting from melorheostosis of the hand, and although there are many theories regarding the etiology of pain, the cause of pain associated with is not known [3].

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Since cryptographic systems on medical devices are susceptible to differential power analysis and fault analysis attacks [29–40], it is critical to analyze the security of Rainbow on hardware.

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To find novel genes in the FHV-1 genome ab initio, and as a second approach to verify the annotation, the sequence was submitted to GeneMarkS (Besemer et al., 2001).

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, 2015), plant nursery runoff (Huett et al., 2005), barnyardmanure (Hill et al.

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The degree of spermatogenic failure in these patients can vary with some producing enough sperm for intracytoplasmic sperm injection [13, 15].

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Previously, preeclampsia has been associated with intrauterine growth restriction, in the setting of dysfunctional placental vascular development and function (18).

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Further studies are still needed to exclude other purines such as ATP and related nucleotides, due to their significant release from bladder urothelium [8,9], and since ATP in some species can inhibit or relax the bladder [33–35].

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development of solutions and improvements to real-world problems (Holmström et al., 2009).

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Feature vectors were classified with a linear Support Vector Machine, for which we used the LIBLINEAR SVM library [8].

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sequence was obtained using the I-TASSER server, which has been developed to generate automated full-length tridimensional protein structural predictions [31-33].

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Social support can also affect individuals’ emotional well-being, including depression, as well as any other experienced adversities (Clara et al., 2003; Hefner & Eisenberg, 2009; Zaleski et al., 1998).

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One of our proposed protocol is based on gossip protocols for completely decentralized distributed applications, such as an environment of [19] and guarantees causal message ordering, which is somewhat similar to temporal message ordering [12], based on logical time not physical time.

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The physical basis of the particular postulated form of U in [31] remains to be elucidated.

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In this study, the Brix model [12, 13], a linear two-compartment open model where in the peripheral compartment has negligible effects on the central compartment, was used because it did not need T10 mapping or arterial input function measurements.

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These criteria were intentionally lenient to prevent discarding any viable results; in actuality, the real amplitudes of crustal plateau short-wavelength folds are likely on the order of 100 m [e.g., Ghent and Hansen, 1999].

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A and tiagabine in native preparations leads to significant prolongation of the postsynaptic response at GABAergic synapses (Dingledine & Korn, 1985; Roepstorff & Lambert, 1992, 1994; Thompson & Gähwiler, 1992; Isaacson, Solis & Nicoll, 1993; Draguhn & Heinemann, 1996; Engel et al., 1998; Rossi &…

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Life history traits are an appropriate and important focus for the study of the ecological and evolutionary importance of polyploidy because (1) life history traits are often main determinants of fitness (e.g., Levy and Feldman 2002; Otto 2007; Ramsey 2011), and (2), ploidy level has the potential to influence life history traits in both positive and negative ways (e.

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FIS quantifies the deviation from HWE with negative values indicating an excess of heterozygotes, and positive values indicating an excess of homozygotes (see de Meeûs et al., 2007a for a thorough explanation).

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, 2010) but also genetic or epigenetic modifications, contributing to cellular senescence (Dahl et al., 2008; Bork et al., 2010).

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‚Ä¶in bulk cytosolic Ca21 concentration, caused a significantly smaller activation of MAPK in comparison with that resulting from glutamate receptor stimulation, supports the hypothesis that MAPK requires high localized Ca 21 rises for its activation in neurons (Finkbeiner and Greenberg, 1996, 1997).

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To determine if the missing protein coding genes (belonging to the last two groups) were actually present in the draft sequence but
Data is shown for six sequencing technologies; omitted is Illumina PacBio for which there are currently only eight genome projects without any missing genes. doi:10.1371/journal.pone.0048837.g006
PLOS ONE | www.plosone.org 5 December 2012 | Volume 7 | Issue 12 | e48837
had not been predicted by Prodigal, tBLASTn was used to search for those genes in the draft contigs.

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, 1997), have focused on representing specific tasks and domains, the attention has shifted to more general purpose schemas such as the Dialogue Act Markup using Several Layers (DAMSL) (Allen, 1997) and the ISO 24617-2(Bunt et al., 2010; Bunt et al., 2012), a standard for dialog act annotation.

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Variability in the data, in terms of variability of each behavior relative to the variability of other behaviors, and the total variance of the whole composition, is described in Appendix 3 through a variation matrix [11, 16] within each domain.

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5 ms than a larger response (Sanger et al. 2001; Roshan et al. 2003) because SICI depends on the inhibition of late I-waves that are only recruited in larger MEPs.

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…of people and evaluations of self are associated with medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC) activity (e.g., Vogeley et al. 2001; Harris et al. 2005; Mitchell et al. 2005; Ochsner et al. 2005; Lindner et al. 2008; Krienen et al. 2010 but see Kelley et al. 2002).

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8 percent for selected rules Snort and ClamAV, compared with several existing bit-split string matching approaches in [8], [9], [10], and [4].

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[43] Results from this trial have been fully reported in several published papers.[43-46] Some of the results differ slightly between published papers.

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As noted by Schoonbaert and Grainger (2004) and by Dehaene et al. (2005), in models using open-bigram coding schemes (Grainger & van Heuven, 2003; Whitney, 2001), repeated letters imply repetition at the bigram level.

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There is consistent evidence pointing to the contribution of a membrane receptor in dopaminergic neuroprotection exerted by estradiol [10, 33].

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We note that although PSIPRED was not optimized for peptides, the resulting fragment libraries showed in practice good coverage of the peptide conformational space (in concordance with a recent report by Vanhee et al. that most peptide-protein interactions can be represented by fragment sets derived from single, non-related monomer structures [17]).

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White-nose syndrome has often been assumed to be the key cause of regional population declines in hibernating bat species in the region we studied, due to repeated observations of mass mortality events associated with the disease [22,32,34,86].

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…were aimed at confirming the presence of PLCb1 in close vicinity to postsynaptic densities as previously observed by biochemical (Taguchi et al., 2007) and ultrastructural approaches (Fukaya et al., 2008), as well as to define the precise location of nuclear PLCb1 in native nervous tissue.

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…be accepted when different inhibitor concentrations are assayed and if consistent results are obtained as follows: the best-fitting model possesses the same number of components with the same amplitudes and kinetic constants for each tested inhibitor concentrations (Estévez and Vilanova 2009).

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Additionally, it is important to consider that most studies linking higher vancomycin MIC values to poorer therapeutic outcome have used Etest.(16,64,65) When treating individual patients with daptomycin, clinicians should also be aware that there are rare daptomycin nonsusceptible isolates present in this population of organisms.

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A stock Tween 80 conidia suspension containing 6.4 x 10 8 conidia/ml was freshly prepared according to Rosengaus et al. (1998).

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Nevertheless, in establishing and keeping stable social relations, ‘negative’ stimuli are necessary (Ohl, 2011).

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Similar to our results, the heart exhibited a high AhRR mRNA content (Korkalainen et al. 2004).

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…that the activation of mTOR signaling is necessary for the increases in protein synthesis and muscle mass that occur in response to elevated mechanical loading (Bodine et al., 2001; Drummond et al., 2009; Goodman et al., 2011a; Gundermann et al., 2014; Hornberger et al., 2004; Kubica et al., 2005).

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The balls usually have a theme that guides how HBC members will represent their categories for that ball event, along with core categories for each dominant gender, ‘butch queen’ (gay and bisexual men) and ‘femme queen’ (transgender women) (Galindo, 2013).

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This iterative method allowed for the identification, analysis and reporting of patterns (themes) that had arisen within the data (Braun and Clarke 2006).

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In a recent elegant study performed on choroid plexuses obtained from neonatal and adult rats and in an in vitro model of the blood-CSF barrier, the active transport of Mn through the basolateral membrane of epithelial cells was shown to be partially saturable, unidirectional (from the blood to the CSF) and influenced by prolonged exposure of both Mn and Ca (Schmitt et al., 2011).

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WAT collection and flow cytometry As we previously described (5, 11), human WAT (>150 samples) was obtained after the signature of an informed consent from women undergoing breast reconstruction.

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United Stated were treated with radiotherapy, and this number is expected to increase in the next several years [1].

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Such truncated phospholipids can activate PMNs, monocytes, eosinophils as well as platelets and are validated to be the major components of oxidized low density lipoprotein (OxLDL) that promotes atherogenesis [16,25,26] in atherosclerotic plaque [27], smokers and alcoholic blood [28,29], inflamed tissues [30] and in models of cutaneous inflammation [31].

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In order to discern differential sensitivity to apoptosis under NG and HG conditions HG- and NG- treated cells were exposed to the apoptotic inducer DTT [37].

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Moreover, canids are the only known eutherian mammals to carry a Prdm9 which has acquired disruptive mutations (Mu~noz-Fuentes et al. 2011; Ponting 2011; Axelsson et al. 2012) (a marsupial, the opossum Monodelphis domestica, has a Prdm9 which lacks zinc fingers; Ponting 2011).

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Particularly, in non-psychiatric patients, it has repeatedly been found that an increased use of maladaptive strategies, like avoidant coping and/or decreased use of adaptive strategies involving emotionfocused or problem-focused strategies were associated with suicidal behaviour (D’Zurilla et al., 1998; Li & Zhang, 2012; Pietrzak et al., 2011; Sugawara et al., 2012; Tang & Qin, 2015).

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05).
by guest on O ctober 6, 2016
http://brain.oxfordjournals.org/ D ow nloaded from
both KCNQ and Kir2 potassium currents (Galarraga et al., 1999;
Shen et al., 2005, 2007), thereby favouring LTP induction
(Calabresi et al., 2000; Bonsi et al., 2008).

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Thr545 of ACAP4 is a cognate substrate of MST4 Our recent work has established the essential role of MST4 in gastric parietal cell activation (11).

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As done by the speech expert, the feature vectors resulting from featur vector concatenation were processed by the VAD (Section 4.2).

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…of Ubc9 and Smt3 arrest with short spindles and high levels of Pds1
It was reported previously that yeast ubc9 D cells, which were kept alive by UBC9
expressed from the galactoseinducible GAL1-10
promoter, arrested in mitosis upon promoter shut-off in glucose medium (Seufert et al
., 1995).

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Based on recent knowledge, cells may not opt for the germline mutation in an attempt to counteract haploinsufficiency, which, as shown for BRCA1, results in genomic instability and premature senescence in human breast epithelial cells [29].

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…neurotoxin 1-methyl-4-pheyl-1,2,3,6tetrahydropyridine (MPTP) to mimic the key clinical and pathological features of PD in man and subhuman primate species has provided a useful model in which to study treatment strategies for PD (Ballard et al., 1985; Burns et al., 1983; Crossman et al., 1987).

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In accordance with previous studies, we used a cut-off score of .85 to assign participants to the high versus low cardiac perception group (e.g. Montoya et al., 1993; Pollatos et al., 2005; Schandry et al., 1986).

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Concentration data were requested for As, Cd, Cu, Fe, Mn, Ni, Pb and Zn, which represent the most common (and most commonly measured) pollutants discharged from abandoned metal mines in England and Wales (Mayes et al., 2009).

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…some extensions of the above factorization methods are proposed, including the TrAnsfer Learning for MUltiple Domains (TALMUD) (Moreno et al., 2012), the extended Cluster-level Latent Factor Model (CLFM) (GAO ET AL., 2013B;A) and the Cross-Domain Triadic Factorization (CDTF) (Hu et al., 2013).

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P-VS plots of SA1 from 11 to 60 GPa are fitted with a fourth order polynomial (R 2 = 0.9933) and P-VS plots of SA2 from 10 to 59 GPa are fitted with a quadratic function (R2 = 0.9957)
also observed in SiO2 glass (Murakami and Bass 2010) and MgSiO3 glass (Murakami and Bass 2011).

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To facilitate detection of metagenomic SSU rRNA sequences matching sequences in the SILVA database (release 126) [12], all bacterial SSU rRNA sequences ≥ 1200 bp deposited in the SILVA database (release 126) [12] were added to the initial data set and a second clustering at 97% and consecutively 85% sequence similarity threshold was performed (version 9.

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quency (2–32 kHz), and the range of BFs mapped in all regions covered the range of pinna-related frequency and ILD cues in the rat (Koka et al., 2008; Tollin and Koka, 2009).

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The effect of O2 appears to be mediated at least in part by prolyl 4-hydroxylation of Skp1, because elevated O2 levels are required by phyA – and Skp1-overexpression strains, and lower O2 is required by PhyA overexpression and Skp1B cells [10,24].

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Availability of high biological value of animal proteins, essential amino acids and fatty acids, vitamins and other nutrients are the other reasons to ensure its popularity among masses (Biesalski, 2005).

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shown to produce similar outcomes to FU-based chemotherapy.(122,123) The next major advance came with the addition of bevaci-

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Another approach is to fit a distribution of selective effects to the SFS (Eyre-Walker et al., 2006; Keightley and Eyre-Walker, 2007; Boyko et al., 2008; Schneider et al., 2011).

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All of the aforementioned methodologies assign a primary role to observation (Baker, 2006), which is defined as the “systematic recording of observable phenomena or behavior
JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY
in a natural setting” (Gorman & Clayton, 2005, p. 40).

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The study results support findings from similar studies using VIA screening, which have demonstrated the effectiveness, safety, and feasibility of a screening program based on VIA testing [2–12,16].

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Hennessy and Milner showed in (Hennessy and Milner, 1985) that, over imagefinite labelled transition systems, strong bisimilarity also coincides with the relation

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In this section, we evaluate our approach on two challenging datasets, i.e., UCF50 [13] and HMDB51 [14].

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, 2009; Kelly and Simpson, 2001) and to develop practitioner roles (Williamson et al., 2004).

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Performing routine screening for asymptomatic CAD in all patients with type 2 DM is debatable for several reasons (26-28).

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In addition, some examined the appropriate monitoring frames to reliably estimate habitual physical behaviour intensities individually [5, 6].

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This concurs with other data on Myh13 expression (6) and may explain this transcript’s sensitivity to postnatal visual/vestibular deprivation (5, 7).

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The gross distribution of PLCb1-immunohistochemical staining in the rat central nervous system described here is consistent with previous evidences in mice, showing a predominant expression of PLCb1 protein (Gerfen et al., 1988; Hannan et al., 1998; Hozumi et al., 2008; Fukaya et al., 2008) in cerebral cortex, caudate–putamen and hippocampus, along with lower levels in diencephalon, brainstem and cerebellum.

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The participants completed the Hand10, the DASH-JSSH [9, 10], and the Revised Hasegawa Dementia Scale (HDSR) questionnaires [11] twice, with an average interval of 10 days.

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…2005), wild fires (Gancet et al., 2005; Merino et al., 2006), victims (Kuiper and NadjmTehrani, 2006; Murphy et al., 2008), objects (Stirling et al., 2010) and other targets of interest (Altshuler et al., 2008; Cole et al., 2006; Ruini and Cangelosi, 2009; Sauter et al., 2005; Yang et al., 2005).

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We adapted our paradigm from a recent study that reported significantly better recall of prices of everyday items in healthy adults when price information was consistent with prior knowledge than when it was inconsistent (Castel, 2005).

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The small proportion of 50-RACE products containing exon 1c that we previously reported for human and mouse was an underestimate caused by the difficulty of amplification of this 93% GC fragment (Drews et al. 2005).

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Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].

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They are applicable in scenarios such as designing questions for reading comprehension (Du et al., 2017; Zhou et al., 2017a; Yuan et al., 2017), and justifying the visual understanding by generating questions to a given image (video) (Mostafazadeh et al.

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Previously published data for both fungi and bacteria are in agreement with these results (Moleyar and Narasimham 1986; Carson and Riley 1995; Griffin et al. 1999; Adegoke et al. 2000; Cox et al. 2001; Inouye et al. 2001).

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Care giving is defined as the process of undertaking the activities and responsibilities of care giving (Stetz & Brown, 1997).

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These concentrations are similar to those determined in prior tivozanib monotherapy trials [5, 6].

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Two such factors predicting enhanced Delta REM (and thereby predicting substantial REM rebound) as suggested in several studies include: 1) a lower amount of REM sleep on diagnostic PSG (strong association) and 2) a higher severity of OSA as noted by the AHI during diagnostic PSG (weak association, if any).

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…procedures for 2-dimensional gel electrophoresis (2DE) were based on those described previously (Cruz-Topete et al. 2011a; Cruz-Topete et al. 2011b; Cruz-Topete et al. 2011c; Christensen et al. 2011; Ding et al. 2011; Ding and Kopchick 2011; Okada et al. 2010; Sackmann-Sala et al. 2009; List et…

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Habitat use was simply defined as the percent of observed pairs associated with a given habitat type over the total number of pairs detected in all habitats (Manly et al. 2002).

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Communitybased cross-sectional surveys in Philippines,[21] Nigeria,[22] Bangladesh,[15] and India[19] have also reported similar findings [Table 1].

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The author of case series of human patients stated that as the window width was increased, the foreign bodies were more easily identified and better differentiated from a gas or fluid build up due to the wood’s absorptive characteristics and the duration of the injury.(15)

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, 1989), numerous inositol trisphosphate receptor genes have been identified and grouped into a family of transient receptor potential (TRP) channels (Vannier et al., 1998; Blondel et al., 1993; Maranto, 1994; Ross et al., 1992; Sudhof et al., 1991).

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using the Reading Span [40], and the Digit Span, a subtest of the WAIS; Visual-motor processing and attention (VSM), was assessed with the Digit Symbol Test, a subtest of the WAIS, the Trailmaking test, part B (TMT; [41]) and the Color-WordInterference test [42], one of the most widely used paradigms for the evaluation of selective attention; Abstraction and conceptual flexibility (ABS) were assessed by means of the modified Wisconsin Card Sorting Test (number categories and perseverative

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[85], the technique for transforming Overlapping B-trees to a STAM can also be applied to other classical temporal access methods [84], especially to those that are modifications of the B-tree family.

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In the yeast Sac. cerevisiae, mutation in genes BNI1, BUD3, BUD6 and SPA2, which regulate polarity and proper cell development, triggers cellpolarity phenotypes (Amberg et al., 1997; Chant et al., 1995; Sagot et al., 2002; Sheu et al., 1998).

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Presumably, NusA stimulates formation of the DNA/RNA hybrid that substitutes for the terminator hairpin (126), consistent with previous views of NusA function (41, 138).

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IKr reduction may be caused by dual mechanisms, acute inhibition of hERG channels and chronic drug-induced disruption of hERG protein trafficking into the cell surface membrane (Ficker et al. 2004; Cordes et al. 2005; Kuryshev et al. 2005; Wible et al. 2005; Rajamani et al. 2006; Thomas et al. 2006; Guo et al. 2007; Takemasa et al. 2007; Wang et al. 2007; Van der Heyden et al. 2008; Obers et al. 2010; Staudacher et al. 2010).

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It performs three fundamental functions: it binds a spermatozoon—thus preventing interspecies fertilization; it induces the acrosome reaction of the spermatozoon; and, finally, immediately after fertilization, it prevents polyspermy (Baker et al. 2000; Bleil and Wassarman 1990; Herrler and Beier 1999; Serrano and Garcia-Suarez 2001;Thaler and Cardullo 2002; Yanagimachi 1994; Zhao and Dean 2002).

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Further evidence is provided by Mammucari et al who have discovered that integration of the Notch and NFAT/calcineurin signaling pathways seems to be important for keratinocyte differentiation [6] and Zanotti et al who have identified Notch and NFAT signaling as reciprocally inhibiting pathways that together regulate osteoblast function [7].

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The pCEFLHA-HMGA1, pCEFL-HA-HMGA2, pCEFL-HA-HMGA1 (1–43) and pCEFL-HA-HMGA2 (1–73) vectors were previously described (Fedele et al., 2006; Pierantoni et al., 2001; Pentimalli et al., 2008).

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The 4-year survival of 73% in the AFB/MEVP cohort compares favorably with the long-term survival reported by other centers of excellence.(29,30) Perhaps more importantly, however, the long-term survival demonstrated with the use of AFB/MEVP equates the long-term survival reported by our group after open repair of standard infrarenal aortic aneurysms.

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Instead of atzA, the functional homolog, trzN gene (Mulbry et al. 2002), may be more commonly observed in the environment (Arbeli and Fuentes 2010).

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[22, 23, 27] In brief, the technician administered a topical anaesthetic to the participant’s eye to temporarily suppress the corneal blink reflex.

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1 was expressed with ABI1-HA or mER7 control DNA (Yoo et al., 2007) in 3 mL of protoplasts (6 3 105 cells) under standard conditions.

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method developed in [6,8] and improved in [10,18], where we first discretize in space, using a Finite Difference scheme, then discretize in time, using an implicit multistep scheme, of the BDF family (Backward Differentiation Formula).

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The fastq files were trimmed and filtered with skewer [37] and aligned to the Gy14 reference genome with bwa mem [38].

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Some studies suggest a conservative approach (23, 24), while others support more radical treatment (18, 25, 26); there is, however, a lack of studies distinguishing between different types of oral infections.

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The impact of additional diagnostic technologies is sensitive to the technology’s ability to improve surgical decision-making and the ability of surgery to produce cost-effective outcomes [41].

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Differences in genetic background and/or testing conditions could also contribute to the modest differences between our locomotor data and that of Tian and coworkers (Tian et al. 1997).

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This paper reports on the results of studies we have completed in the Victorian (Australia) public health care sector (Bartram et al., 2007, Leggat et al., 2005, 2006, 2008, 2010; Young et al., 2010; Bonias et al., 2010; Stanton et al., 2010).

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We previously studied laparoscopic ovarian cystectomy using a single ancillary port and we obtained similar results regarding patient satisfaction with the operation scar (Capar et al. 2009).

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Traditional,
dichotomous approaches to studying teams as either dispersed or collocated mask the configuration-based effects highlighted in this study, resulting in an obvious loss of accuracy (O’Leary and Cummings 2007).

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Conditional double mutants of trf4 with top1-7 showed ribosomal DNA (rDNA) condensation phenotypes (Sadoff et al, 1995; Castano et al, 1996), and were reported to display defects in mitotic segregation (Wang et al, 2000; Edwards et al, 2003).

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Human epidermal growth factor receptor type 2 (HER2) is located on chromosome 17q21 and is a transmembrane tyrosine kinase growth factor receptor [12].

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The same results were obtained by Winther and Nathalang [27] and by Knoll-K√∂hler [14], who did not determine any difference in the anaesthetic action profiles of a 2 and 4% solution of articaine or a 74-mM (=2.4% solution) and a 148-mM (=4

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Our results concurred with a previous observation in NIH 3T3 cells during adhesion to FN (31), but contrast with the finding in HeLa cells during adhesion to gelatin (44).

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ICD indication was defined according to Class I recommendations in current clinical guidelines (4,5): chronic LVEF 30% or chronic LVEF 30% to 35% in patients in New York Heart Association functional class II or III.

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MuTAIL is a recent adaptation of this approach to the analysis of Mu insertion sites (Settles et al., 2004, 2007).

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The efficacy is defined in terms of the ARs of the vaccinated and unvaccinated groups [20],

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From results reported here, and those in previous works (recent works of particular importance to this report are: Chapple and Krans 2004; Krans and Chapple 2005), we have adopted the following conclusions: (1) The reflex generation of force is profoundly nonlinear and the first phase may act like…

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Autogenous bone grafts are still the most effective bone substitutes and are therefore considered the gold standard [1,2].

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[20] have reported postoperative results 2 years after Wxation of 200 proximal humerus fractures with the Humerusblock.

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Thus, Pro accumulation is widely considered an anti-stress indicator (Verbruggen and Hermans 2008).

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It is safe, however, to conclude that in humans, reciprocity is considered a major value given the importance attached to norms prescribing it (Gouldner 1960) and the function of gratitude (McCullough et al. 2001; Trivers 1971).

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Hyper-parameter settings: We kept the hyper-parameter setting for the biLSTM transducer similar to the one reported in [5].

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…2002); (2) spike-frequency adaptation is elicited by phase 1 high-frequency spiking and acts to reduce spike rate during following depolarization
(Krans and Chapple 2005); (3) the dynamics of muscle shortening may change with motoneuron frequency and over time when activated (Chapple 1989b;…

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Because a7 subunits are glycosylated (Gotti et al., 1992; Chen et al., 1998) and possess several phosphorylation consensus sites (Seguela et al.

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…animal models have shown the antipsychotic and procognitive effects of asenapine (McLean et al. 2010; Marston et al. 2009; Frånberg et al. 2008), which have now been clinically validated in the treatment of acute schizophrenia (Kane et al. 2010; Potkin et al. 2007; Weber and McCormack 2009).

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