Newsgroup: it.salute
Titolo: La chemioterapia uccide:allarme dagli USA

Today's healthnews from Reuters Health Information
Unexpectedly high mortality rate associated with chemotherapy regimen
more news...
Last Updated: 2001-05-17 10:00:14 EDT (Reuters Health)
WESTPORT, CT (Reuters Health) - Researchers have detected a higher than
expected fatality rate associated with an irinotecan, fluorouracil and
leucovorin regimen that is approved by the US Food and Drug Administration
for colorectal cancer.
This finding, which will be published in a letter to the editor in the June
21st issue of The New England Journal of Medicine, was released early due to
the "potential importance with regard to the treatment of patients with
colorectal cancer."
Dr. Daniel J. Sargent, of the Mayo Clinic, in Rochester, Minnesota, and
colleagues conducted two clinical trials in which one arm of each included
this regimen. Dosages were "125 mg of irinotecan/m² of body-surface area, 20
mg of leucovorin/m², and 500 mg of fluorouracil/m² once weekly for 4 of
every 6 weeks."
Within 60 days after the initiation of treatment, the mortality rate in one
trial, which contained patients with metastatic colon cancer, was 4.8% in
those receiving this treatment versus 1.8% for the other treatment arm. In
the other trial, which enrolled patients with resected stage III colon
cancer, the rates were 2.2% and 0.8%, respectively.
The side effects in the latter trial "appeared to be more related to blood
clot abnormalities: pulmonary emboli, deep vein thromboses, strokes, heart
attacks," Dr. Michael J. O'Connell, also of the Mayo Clinic, told Reuters
Health.
"One interesting possibility is that these patients had just undergone major
abdominal surgery with general anesthesia within the 4 weeks prior to
beginning the treatment," he continued. "Perhaps the postoperative setting
predisposed those patients to these thrombotic events."
As a result of these findings, Dr. O'Connell said, in their clinical
practice and in the extension protocol they have planned, they have
decreased the dose of irinotecan and fluorouracil.
The P values for the differences in both trials were 0.06. Dr. Sargent told
Reuters Health: "In the interest of patient safety, I would not hold this to
a statistical standard. We have two studies that both show a strong trend
toward increased death rates. It's the consistency of the two studies that,
when taken together, makes this a clinically significant finding."
The researchers still believe that combination therapy with irinotecan,
fluorouracil and leucovorin should be an option for patients with advanced
colorectal cancer, but that patients should be vigilantly monitored. They
add that "an alternative is the FDA-approved infusional schedule reported by
Douillard et al. and described in the irinotecan package insert."
The letter can be accessed at 
http://www.nejm.org
.
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 ha scritto nel messaggio
news:zHQN6.13583$Ql3.6...@news.infostrada.it...

Finalmente qualcuno si muove per fermare il massacro !
I protocolli standard NON funzionano !
I cancerosi debbono fare altre terapie non invasive:
www.medicinenaturali.net
 /cancro
G. Paolo

 G. Paolo
 E quali? vediamo se indovino: urina? bicarbonato? allora si che sarebbe un
massacro! Vanoli, di solito fai ridere, ma certe volte fai veramente schifo!
e' inutile dire che dovresti vergognarti di speculare anche su simili
tragedie per guadagnarti le tue luride centomila lire. Con rinnovato schifo.
Marius


--
Vincenzo Cordiano, ematologo 
emato...@hotmail.com
Il Sito Italiano di Ematologia
http://web.tiscalinet.it/ematologia/index.html

 G. Paolo
Non sono (ancora) un medico per cui non ho facoltà di commentare ciò che dici,ma
una copsa posso diirtela: IMPARA A QUOTARE SE VUOI POSTARE NEI NG!
Matteo
--
"Tu sei la Morte, tu uccidi le persone!-
-Io?-disse la Morte profondamente offesa"
    ~~~
   (. .)
ooO (_) Ooo
-----~--------------------------------------
"Where have you gone Susan Lewis.
Where have you gone Anna del Amico.
A newsgroup turns it's lonely eyes to you"
--------------------------------------------
icq uin: #7398493
Membro del MASSM


ancora con la probabile polmonite? non hai lastrine nuove? e si che di malati di
cancro ce ne sono eccome!!!!


risolvere il problema costa anche pochissimo !
Solo 100.000 Lit. !!!
Bye, Alessio

 Non sono (ancora) un medico per cui non ho facoltà di commentare ciò
che dici
Bhè, lui non lo è mai stato, per cui non metterti problemi. Basta essere
esseri pensanti, per commentare! ;-)
Saluti
Lella