Newsgroup: it.salute
Titolo: novita' bicarbonatiche

http://tinyurl.com/a5dx5wa
 
 

 
http://tinyurl.com/a5dx5wa
 
 
Le novitï¿½ che davvero contano non sono le cose scritte in quel libercolo,
ma le risultanze di questi studi recenti (il secondo ï¿½ quello che citano):
 
 
http://www.ncbi.nlm.nih.gov/pubmed/23261451
  (2013)
 
   Acidosis blocks CCAAT/enhancer-binding protein homologous protein
   (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator
   of apoptosis (PUMA) during amino acid starvation.
 
   Ryder CB, McColl K, Distelhorst CW.
 
  Cancer cells must avoid succumbing to a variety of noxious conditions
  within their surroundings. Acidosis is one such prominent feature of
  the tumor microenvironment that surprisingly promotes tumor survival
  and progression. We recently reported that acidosis prevents apoptosis
  of starved or stressed lymphoma cells through regulation of several
  Bcl-2 family members (Ryder et al., JBC, 2012). Mechanistic studies
  in that work focused on the acid-mediated upregulation of anti-apoptotic
  Bcl-2 and Bcl-xL, while additionally showing inhibition of glutamine
  starvation-induced expression of pro-apoptotic PUMA by acidosis.
  Herein we report that amino acid (AA) starvation elevates PUMA,
  an effect that is blocked by extracellular acidity. Knockdown studies
  confirm that PUMA induction during AA starvation requires expression
  of both CHOP and c-Jun. Interestingly, acidosis strongly attenuates
  AA starvation-mediated c-Jun expression, which correlates with PUMA
  repression. As c-Jun exerts a tumor suppressive function in this and
  other contexts, its inhibition by acidosis has broader implications
  for survival of cancer cells in the acidic tumor milieu.
 
 
http://www.ncbi.nlm.nih.gov/pubmed/23288510
  (2013)
 
   Acidity generated by the tumor microenvironment drives local invasion.
 
   Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH,
   Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM,
   Sloane BF, Johnson J, Gatenby RA, Gillies RJ.
 
  The pH of solid tumors is acidic due to increased fermentative
  metabolism and poor perfusion. It has been hypothesized that acid pH
  promotes local invasive growth and metastasis. The hypothesis that
  acid mediates invasion proposes that H+ diffuses from the proximal
  tumor microenvironment into adjacent normal tissues where it causes
  tissue remodeling that permits local invasion. In the current work,
  tumor invasion and peritumoral pH were monitored over time using
  intravital microscopy. In every case, the peritumoral pH was acidic
  and heterogeneous and the regions of highest tumor invasion corresponded
  to areas of lowest pH. Tumor invasion did not occur into regions with
  normal or near-normal pHe. Immunohistochemical analyses revealed that
  cells in the invasive edges expressed the glucose transporter GLUT-1
  and the sodium-hydrogen exchanger NHE-1, both of which were associated
  with peritumoral acidosis. In support of the functional importance of
  our findings, oral administration of sodium bicarbonate was sufficient
  to increase peritumoral pH and inhibit tumor growth and local invasion
  in a preclinical model, supporting the acid-mediated invasion hypothesis.
 
Queste risultanze non mi stupiscono, perchï¿½ oltre due anni fa io scrissi:
 
 
http://groups.google.com/forum/?fromgroups#!topic/it.salute/0EZzxhZOXzI
 
   Il cancro si potrï¿½ curare anche con bicarbonato e melatonina?
 
Notate che qualche idiota malato di mente (sospetterei qualche fanatico
cicaprone di it.salute) ha cancellato il mio primo post in quel thread.
 
Bye,
 
  *GB* 
 


da questi studi sembra che il bicarbonato non puo' essere efficace, per il
semplice motivo che e' lo stesso cancro a crearsi il suo microambiente acido
in cui sopravvive
 

 microambiente acido in cui sopravvive
 
Straparli come fai spesso. Per�, prima di riportare qualcosa dal
full text di quell'articolo, voglio vederti litigare con Arancino.
Fuffaro contro fuffaro: sar� una bella lotta. :-)
 
Bye,
 
  *GB* 
 
 

 full text di quell'articolo, voglio vederti litigare con Arancino.
 
Non capisco perche'dovrei litigare con lui.
Solo ad un povero troll (casina docet) puo' venire in mente
una cosa del genere.
 
 
 
 
 

 una cosa del genere.
 
E solo a un povero demente pu� non venire in mente che Jinx ha scritto
che tu sei un fuffaro assolutamente privo di logica e coerenza.
 
Bye,
 
  *GB*