Newsgroup: it.scienza.chimica
Titolo: ninidrina

Vorrei sapere se la ninidrina e' cancerogena e dove poter trovare
informazioni sulla tossicita' di vari composti.
paol...@zeus.sns.it
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Tipicamente un prodotto è da definirsi cancerogeno se sull'etichetta
contiene la scritta R45/49. Riferirsi al DL.626/94 per i prodotti
cancerogeni già definiti o sospetti tali. Per le soluzioni c'è un limite di
cancerogenicità (conc. > 0.5%) (non sono sicuro, check su DL 626/94) Alcune
regole da tenere sulla sicurezza del laboratorio sono presenti sul sito
http://www.geocities.com/p.cappella/labchbio.htm
 . Quanto alla scheda di
sicurezza puoi far riferimento al sito della sigma-aldrich www.sigma-aldrich
che con la semplice registrazione "gratis" permette di avere tutte le info
sui suoi prodotti ... sono migliaia. Le schede di sicurezza si trovano sotto
MSDS (Material Safety Datasheet). Un'altra indicazione la puoi trovare sul
catalogo della Sigma-Aldrich dove sono presenti oltre al nome IUPAC, MW e
CAS number (indispensabile aiuto di ricerca info senza conoscere l'esatto
nome IUPAC della sostanza) anche le frasi di rischio (R) e di sicurezza (S).
L'elenco generale di cosa vuol dire lo trovi all'inizio del catalogo.
Per altre info su MSDS e ricerche di prodotti chimici prova con:
http://www.geocities.com/p.cappella/address_book.html
Ciao Paolo Cappella
Dalla sigma-aldrich (informazioni libere di divulgazione): MSDS Ninidrina:
Synonyms: 2,2-Dihydroxy-1,3-indanedione
1,2,3-Indantrione hydrate
Molecular Formula: C9H6O4
Molecular Weight: 178.1
CAS: 485-47-2
Comments: Soluble in water with sonication (50 mg/ml) or ethanol (100 mg/
ml).
Storage Temp: Store at RT.
R&S: R: 20/21/22,36/37/38, S: 26,28.1,36
Literature References: Moore, S., Amino acid analysis: aqueous dimethyl
sulfoxide as solvent for the ninhydrin reaction. J. Biol. Chem. 243,
6281-6283 (1968).
James, L.B., Amino acid analysis: ninhydrin reaction with titanous chloride.
J. Chrom. 152, 298-300
M A T E R I A L S A F E T Y D A T A S H E E T SECTION 1. - - - - - - - - -
CHEMICAL IDENTIFICATION- - - - - - - - - - CATALOG #: N4876 NAME: NINHYDRIN
SIGMA GRADE CRYSTALLINE SECTION 2. - - - - - COMPOSITION/INFORMATION ON
INGREDIENTS - - - - - - CAS #: 485-47-2 MF: C9H6O4 EC NO: 207-618-1 SYNONYMS
2,2-DIHYDROXY-1,3-INDANDIONE * 2,2-DIHYDROXY-1H-INDENE-1,3(2H)-DIONE *
1,2,3-INDANTRIONE, 2-HYDRATE * 1,2,3-INDANTRIONE MONOHYDRATE * NINHYDRIN *
NINHYDRIN HYDRATE * TRIKETOHYDRINDENE HYDRATE * SECTION
3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - - LABEL
PRECAUTIONARY STATEMENTS HARMFUL HARMFUL BY INHALATION, IN CONTACT WITH SKIN
AND IF SWALLOWED. IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
RUBEFACIENT. IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE. AFTER CONTACT WITH SKIN, WASH IMMEDIATELY
WITH PLENTY OF WATER. WEAR SUITABLE PROTECTIVE CLOTHING. SECTION
4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - - IN CASE OF
CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. IF INHALED,
REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING IS DIFFICULT, GIVE OXYGEN. IF SWALLOWED, WASH OUT MOUTH WITH WATER
PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING
BEFORE REUSE. SECTION 5. - - - - - - - - - FIRE FIGHTING
MEASURES - - - - - - - - - - EXTINGUISHING MEDIA WATER SPRAY. CARBON
DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. SPECIAL FIREFIGHTING
PROCEDURES WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING
TO PREVENT CONTACT WITH SKIN AND EYES. UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS. SECTION 6. - - - - - - - -
ACCIDENTAL RELEASE MEASURES- - - - - - - - - WEAR SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG
AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH
SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. SECTION 7. - - - - - - - - - -
HANDLING AND STORAGE- - - - - - - - - - - REFER TO SECTION 8. SECTION
8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - - WEAR
APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT GLOVES,
SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING. USE ONLY IN A CHEMICAL FUME HOOD.
SAFETY SHOWER AND EYE BATH. AVOID INHALATION. AVOID ALL CONTACT. AVOID
PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY AFTER HANDLING. KEEP TIGHTLY
CLOSED. STORE IN A COOL DRY PLACE. SECTION 9. - - - - - - - PHYSICAL AND
CHEMICAL PROPERTIES - - - - - - - APPEARANCE AND ODOR WHITE TO YELLOW POWDER
PHYSICAL PROPERTIES MELTING POINT: 250 C (DEC) SECTION
10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
INCOMPATIBILITIES STRONG OXIDIZING AGENTS MAY DISCOLOR ON EXPOSURE TO LIGHT.
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS TOXIC FUMES OF: CARBON
MONOXIDE, CARBON DIOXIDE SECTION 11. - - - - - - - - - TOXICOLOGICAL
INFORMATION - - - - - - - - ACUTE EFFECTS MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. CAUSES EYE AND SKIN IRRITATION. MATERIAL IS
IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. CAUSES REDDENING
OF THE SKIN. TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ADDITIONAL
INFORMATION THIS MATERIAL IS A RUBEFACIENT. SKIN CONTACT WILL RESULT IN A
REDDING OF THE SITE WITH POSSIBLE INFLAMMATION. RTECS #: NK5425000
1,3-INDANDIONE, 2,2-DIHYDROXY- TOXICITY DATA IPR-MUS LD50:78 MG/KG CRSBAW
151,719,1957 TARGET ORGAN DATA BEHAVIORAL (SOMNOLENCE) VASCULAR (REGIONAL OR
GENERAL ARTERIOLAR OR VENOUS DILATION) LUNGS, THORAX OR RESPIRATION
(DYSPNAE) ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
INFORMATION. SECTION 12. - - - - - - - - - ECOLOGICAL
INFORMATION - - - - - - - - - - DATA NOT YET AVAILABLE. SECTION
13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - - DISSOLVE OR
MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL
INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL,
STATE AND LOCAL ENVIRONMENTAL REGULATIONS. SECTION 14. - - - - - - - - - -
TRANSPORT INFORMATION - - - - - - - - - CONTACT SIGMA CHEMICAL COMPANY FOR
TRANSPORTATION INFORMATION. SECTION 15. - - - - - - - - - REGULATORY
INFORMATION - - - - - - - - - - EUROPEAN INFORMATION HARMFUL R 20/21/22
HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. S 26 IN CASE OF CONTACT
WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S
28 AFTER CONTACT WITH SKIN, WASH IMMEDIATELY WITH PLENTY OF WATER. S 36 WEAR
SUITABLE PROTECTIVE CLOTHING. REVIEWS, STANDARDS, AND REGULATIONS OEL=MAK
NOHS 1974: HZD A1175; NIS 1; TNF 33; NOS 2; TNE 594 NOES 1983: HZD A1175;
NIS 4; TNF 476; NOS 9; TNE 5565; TFE 4002 EPA TSCA SECTION 8(B) CHEMICAL
INVENTORY SECTION 16
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