Newsgroup: it.scienza.medicina
Titolo: Orticaria

Che legami, acceratti, ci sono tra l'orticaria ed una vita alquanto
stressata ?
Vi ringrazio!!

 stressata ?
Alcuni fra gli articoli principali più recenti sull'argomento
sono questi:
J Cutan Med Surg 2001 Mar-Apr;5(2):140-5
The role of psychological stress in skin disease.
Kimyai-Asadi A, Usman A.
The Ronald O. Perelman Department of Dermatology, New York
University School of Medicine, New York, New York 10016, USA.
BACKGROUND: Numerous case reports and studies have suggested that
psychological stress may have a role in the onset or exacerbation
of a variety of skin diseases. OBJECTIVE: We review the
literature pertaining to the role of psychological stress in the
exacerbation of psoriasis, urticaria, eczematous dermatitis,
herpesvirus infections, and other skin diseases; discuss
potential mechanisms of stress-induced skin disease; and review
studies and case reports of psychotherapeutic interventions that
have been found helpful in the therapy of skin diseases.
CONCLUSIONS: There is evidence linking psychological stress to
exacerbation of certain skin diseases. Both the clinical and the
basic science evidence, however, can be hard to interpret in
light of the difficulty of defining and quantifying psychological
stress as well as the questions regarding the etiologic
significance of neuroimmunologic findings in skin diseases.
Publication Types:
Review
Review, Tutorial
PMID: 11443487 [PubMed - indexed for MEDLINE]
Psychother Psychosom 2001 May-Jun;70(3):118-36
Stressful life events and skin diseases: disentangling evidence
from myth.
Picardi A, Abeni D.
Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata
IDI-IRCCS, Rome, Italy.
The possibility of a causal influence of emotional stress,
especially of stressful life events, on the course of various
skin diseases has long been postulated. Clinical wisdom and
experience, as well as many anecdotal observations and
uncontrolled case series, support this opinion. We reviewed the
available evidence on the role of stressful life events in
triggering or exacerbating skin diseases. The role of stressful
events in vitiligo, lichen planus, acne, pemphigus and
seborrhoeic dermatitis was either controversial or insufficiently
explored. The role of stressful events in psoriasis, alopecia
areata, atopic dermatitis and urticaria was apparently clearer.
However, only a few studies met acceptable methodological
standards for stress measurement. Also, few studies considered
common potential confounding factors (e.g. age, duration of
illness, familial factors), and no study controlled adequately
for the influence of other crucial factors (e.g. discontinuation
of treatment, seasonal effects). Adding that the large majority
of studies were retrospective, it seems wise to conclude that
only preliminary evidence has been published so far on the role
of stressful life events in bringing on or worsening any
dermatological disease. Further research is mandatory, either in
the form of prospective studies or, more feasibly, of
well-designed case-control studies with adequate statistical
power. Future studies should also pay more attention to
protective as well as vulnerability factors in stressful events.
Further, it would be important to investigate other sources of
psychological stress, such as chronic stress and everyday stress.
Measuring stress appraisal, although difficult, would also be
important. Copyright 2001 S. Karger AG, Basel
Publication Types:
Review
Review, Tutorial
PMID: 11340413 [PubMed - indexed for MEDLINE]
Biomed Pharmacother 2000 Jun;54(5):258-62 Related Articles,
Books, LinkOut
Stress and skin diseases in musicians: evaluation of the beck
depression scale, general psychologic profile (the brief symptom
inventory [BSI]), beck anxiety scale and stressful life events in
musicians.
Onder M, Cosar B, Oztas MO, Candansayar S.
Gazi University Medical Faculty, Department of Dermatology,
Ankara, Turkey.
We had previously investigated skin problems of musicians (N =
117) working in a professional orchestra. The results of this
survey suggest a significant incidence of occupational and
stress-related skin problems in musicians such as hyperhydrosis,
lichen planus, psoriasis, seborrheic dermatitis and urticaria. It
was thought that emotional factors exacerbate their problems [6].
This article discusses the importance of psychiatric
consultations in dermatologic problems.
Publication Types:
Clinical Trial
PMID: 10917463 [PubMed - indexed for MEDLINE]
Int J Dermatol 1999 Mar;38(3):192-5
Skin problems of musicians.
Onder M, Aksakal AB, Oztas MO, Gurer MA.
Gazi University Medical Faculty, Department of Dermatology,
Ankara, Turkey.
OBJECTIVE: We investigated the skin problems of high level
musicians in a professional orchestra. This study was prompted by
our observation of violinists with skin changes. METHODS:
Ninety-seven musicians were evaluated. Twelve reporting
dermatitis associated with the playing of their instruments were
patch tested. We also examined 20 singers (nonplayers). RESULTS:
Positive patch test reactions to nickel and colophony were found
in only three patients. Musicians were subject to a variety of
skin problems from playing their instruments, however, such as
hyperhidrosis, cheilitis, and calluses of the fingertips. Singers
had skin problems including lichen planus, psoriasis, seborrheic
dermatitis, and urticaria. It was thought that emotional factors
exacerbate their problems. CONCLUSIONS: The results of this
survey suggest a significant incidence of occupational- and
stress-related skin problems in musicians.
Publication Types:
Review
Review of Reported Cases
PMID: 10208614 [PubMed - indexed for MEDLINE]
Endocrinology 1998 Jan;139(1):403-13 Related Articles, Books,
LinkOut
Corticotropin-releasing hormone induces skin mast cell
degranulation and increased vascular permeability, a possible
explanation for its proinflammatory effects.
Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R,
Webster E, Chrousos G.
Department of Pharmacology and Experimental Therapeutics, Tufts
University School of Medicine, Boston, Massachusetts 02111, USA.
Mast cells are involved in atopic disorders, often exacerbated by
stress, and are located perivascularly close to sympathetic and
sensory nerve endings. Mast cells are activated by electrical
nerve stimulation and millimolar concentrations of neuropeptides,
such as substance P (SP). Moreover, acute psychological stress
induces CRH-dependent mast cell degranulation. Intradermal
administration of rat/human CRH (0.1-10 microM) in the rat
induced mast cell degranulation and increased capillary
permeability in a dose-dependent fashion. The effect of CRH on
Evans blue extravasation was stronger than equimolar
concentrations of the mast cell secretagogue compound 48/80 or
SP. The free acid analog of CRH, which does not interact with its
receptors (CRHR), had no biological activity. Moreover, systemic
administration of antalarmin, a nonpeptide CRHR1 antagonist,
prevented vascular permeability only by CRH and not by compound
48/80 or SP. CRHR1 was also identified in cultured leukemic human
mast cells using RT-PCR. The stimulatory effect of CRH, like that
of compound 48/80 on skin vasodilation, could not be elicited in
the mast cell deficient W/Wv mice but was present in their +/+
controls, as well as in C57BL/6J mice; histamine could still
induce vasodilation in the W/Wv mice. Treatment of rats
neonatally with capsaicin had no effect on either Evans blue
extravasation or mast cell degranulation, indicating that the
effect of exogenous CRH in the skin was not secondary to or
dependent on the release of neuropeptides from sensory nerve
endings. The effect of CRH on Evans blue extravasation and mast
cell degranulation was inhibited by the mast cell stabilizer
disodium cromoglycate (cromolyn), but not by the antisecretory
molecule somatostatin. To investigate which vasodilatory
molecules might be involved in the increase in vascular
permeability, the CRH injection site was pretreated with the
H1-receptor antagonist diphenhydramine, which largely inhibited
the CRH effect, suggesting that histamine was involved in the
CRH-induced vasodilation. The possibility that nitric oxide might
also be involved was tested using pretreatment with a nitric
oxide synthase inhibitor that, however, increased the effect of
CRH. These findings indicate that CRH activates skin mast cells
at least via a CRHR1-dependent mechanism leading to vasodilation
and increased vascular permeability. The present results have
implications for the pathophysiology and possible therapy of skin
disorders, such as atopic dermatitis, eczema, psoriasis, and
urticaria, which are exacerbated or precipitated by stress.
PMID: 9421440 [PubMed - indexed for MEDLINE]
Dermatol Clin 1996 Jul;14(3):399-421 Related Articles, Books,
LinkOut
Psychophysiology of stress in dermatology. The psychobiologic
pattern of psychosomatics.
Panconesi E, Hautmann G.
Department of Dermatology, University of Florence, Italy.
Stress is an abnormal or extreme adjustment in the physiology of
an animal to cope with adverse effects of its environment and
management. The adverse effect is designated the stressor. In
this article, the authors try to focus on the main types of host
factors that can influence stress (genetics, perception) and on
the numerous types of stressors (environmental, behavioral,
psychological). Moreover, the authors outline the relevance of
psychosomatic medicine, proposing the examination of psyche and
soma as a unit "in sickness and in health." They focus their
attention on the new aspects of biologic psychosomatics
(psychoneuroendocrinimmunology) in dermatology, suggesting the
possible role of neuropeptides in the pathogenesis of some common
dermatoses such as psoriasis, atopic dermatitis, alopecia areata,
and urticaria.
Publication Types:
Review
Review, Academic
PMID: 8818550 [PubMed - indexed for MEDLINE]
Br J Dermatol 1994 Feb;130(2):199-203 Related Articles, Books,
LinkOut
The relationship between stress and the onset and exacerbation of
psoriasis and other skin conditions.
Al'Abadie MS, Kent GG, Gawkrodger DJ.
Department of Dermatology, Royal Hallamshire Hospital, Sheffield,
U.K.
The role of stressful life events in the progress of various skin
conditions was studied retrospectively in patients who presented
with either psoriasis (where there is some agreement about the
importance of stress), urticaria, acne, alopecia and non-atopic
eczema (where there is some uncertainty regarding the role of
stress), or malignant melanoma, fungal infection, basal cell
carcinoma and melanocytic naevi (where stress is considered less
relevant). When patients in the three groups were matched for
age, those with psoriasis were more likely to report that the
experience of stress pre-dated the onset and exacerbations of
their condition than patients with other skin diseases. For the
psoriasis patients the most common types of life events were
family upsets (such as bereavements), and work or school demands,
but chronic difficulties were also common. There was no
relationship between the severity of stress and time to onset or
exacerbations. The results support the notion that stress is more
likely to be associated with the onset of psoriasis than other
conditions, but also that there may be considerable individual
variation in the ability to cope, suggesting that psychological
interventions may be helpful for particular patients.
PMID: 8123572 [PubMed - indexed for MEDLINE]
    KS