Newsgroup: it.scienza.medicina
Titolo: Fitoestrogeni

Mi piacerebbe sapere notizie sui fitoestrogeni o fitormoni.Qualcuno mi puo'
indicare qualche sito o bibliografia seria?

indicare qualche sito o bibliografia seria?
siti web  ... non credo .
http://web.tiscali.it/no-redirect-tiscali/Scienza_e_Medicina/ng/Consigli.html
punto 9
I moderatori si riservano la facoltà di rifiutare un articolo quando contenga degli
indirizzi di siti sul web......

REDUCTION OF MENOPAUSAL SYMPTOMS WITHOUT USE OF OESTROGENS: THE
EFFICIENCY OF A PARTICULAR SOY EXTRACT IS SCIENTIFICALLY DEMONSTRATED 
 
 
Milan, August 1st 2002 - The Italian company, Indena, which researches
and produces active plant principles and extracts, has undertaken
pharmaco toxicological and clinical studies to explore the
effectiveness of its soy extract, Soyselect. 
Soyselect is a special patented extract characterised by a double
standardisation of isoflavones (13-17%) and saponins (25%). Two
clinical trials on Soyselect, carried out at the Policlinico Gemelli
in Rome, and at the Columbia Hospital in New York, have been published
in the scientific journal Menopause. The two studies mentioned
represent today the only clinical studies on a standardised Soy
extract performed according to the double blind, randomised,
placebo-controlled method. These evaluations have proved the excellent
clinical effect of Soyselect, which, after a six-week treatment,
reduces all menopausal symptoms by 45%. These results are in line with
epidemiological data, which highlight in certain oriental populations,
including the Japanese, a lower incidence of symptoms related to
menopause and post-menopause. Responsible for these differences is the
soy enriching the oriental diet. Indena therefore, set out to test the
efficacy of these active principles with pharmaco toxicological and
clinical methods, thereby corroborating the epidemiological data.
In the clinical study conducted by Indena in conjunction with
Policlinico Gemelli, a progressive diminution of the number of hot
flushes per week was recorded. During the 6 weeks in clinic, 39 women
in menopause, divided randomly in two groups, were administered 50
mg/day of soy isoflavones and placebo. The diminution of hot flushes
was significantly greater in the group treated with Soyselect compared
with those receiving placebo while no aspecific or correlated
side-effect was found with regard to oestrogens. It was concluded that
treatment with Soyselect is well-tolerated and effective against
climacteric symptoms and may be recommended for women who cannot
undergo hormone therapy.
The efficacy of Soyselect is guaranteed due to the presence of two
different specific molecular classes: the isoflavones and the
saponins. Isoflavones are able to imitate some of the biological
effects of oestrogens on menopausal and post-menopausal complaints
without any simultaneous increase in neoplastic risk. Thanks to their
ability to lower cholesterol, saponins are an effective instrument in
preventing cardiovascular damage and, administered orally, are an
excellent vehicle for the isoflavonic component.
Soyselect may be a safe and efficacious therapy for relief of
menopausal symptoms in women who refuse or have indications for not
using HRT. In consideration of its high degree of innovation, the
Indena product has applied for the Italian patent and an international
extension in the USA, Japan, Canada and Australia.
1 Published in Food and Chemical Toxicology 37 (1999) 493-502 and
Breast Cancer Reasearch and Treatment 69 (2001) 153-164
2 Published in Menopause: The Journal of the North American Menopause
Society Vol 7, No. 2 (2000) 105-111; Vol 7, No. 4 (2000) 236-242
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