Newsgroup: it.salute.alimentazione
Titolo: Grassi saturi e insorgenza del diabete tipo 2 in individui geneticamente predisposti

http://www.eurekalert.org/pub_releases/2005-06/uoa-sfc062805.php
Saturated fats combined with genetic trait implicated in development of
type 2 diabetes
Research being published in July issue of Diabetes zeros in on who is
potentially more susceptible to developing the disease
A University of Alberta team of researchers has discovered an additional 2
million Canadians who have a high fat diet or are overweight may be at
increased risk for developing type 2 diabetes if they carry a particular
type of common specific genetic trait known as a polymorphism.
In work published today in the journal, Diabetes, pharmacology professor
Peter Light and graduate student Michael Riedel suggest that saturated and
trans fats are much more effective activators of a specific potassium
channel found in the pancreas--known when activated to reduce insulin
secretion from the pancreas and increase blood sugar levels. This effect,
they say, is amplified in the polymorphic potassium channel. Interestingly,
it seems that polyunsaturated fats are poor activators of the potassium
channel.
"We're suggesting that people with this specific potassium channel
polymorphism--about 2 million Canadians--may be more susceptible to type 2
diabetes if they have a high fat diet or are overweight, two of the biggest
risk factors for type 2 diabetes," Dr. Light explains. "This may explain
why 20 percent of type 2 diabetic Caucasians carry two copies of this
polymorphism in their genes compared to only 10 percent in the non-diabetic
Caucasian population."
The researchers say this discovery opens up the distinct possibility of
specific genetic screening of people at risk for type 2 diabetes, which
would then give physicians additional information to advise their high-risk
patients on preventative diet and exercise options.
About 10 percent of non-diabetic Caucasians who possess this polymorphism
may be at increased risk of developing type 2 diabetes if they consume a
diet rich in saturated and trans fats. These findings provide a plausible
"missing link" between common genetic variations and environmental risk
factors for this very prevalent disease, Dr. Light explains.
The most recent findings build on their previous work. Back in 2003, the
group published a brief genetics report in Diabetes showing that this
common polymorphism in a potassium channel that controls insulin secretion
is much more susceptible to being activated by intracellular fats.
###
The findings will be released in the July issue of Diabetes, the scientific
journal of the American Diabetes Association.
The work is supported by the Canadian Diabetes Association, the Alberta
Heritage Foundation for Medical Research and the Canadian Institutes of
Health Research.
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Nota: "Caucasians" sono in pratica i bianchi, AFAIK

 ha scritto nel messaggio
news:1jsp5sw9gfgza$.dlg@news.lillathedog.net...
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Detto cosě, secondo me, dice poco...
Io vorrei vedere qualche ricerca su diete ad alto tenore di grassi (da fonti
naturali), ma a contenuto apporto di carboidrati (e da fonti buone).
Purtroppo pare che ad oggi quelle che ci sono si riferiscono solo al
dimagrimento.