Newsgroup: it.salute.alimentazione
Titolo: Carboidrati, olio d'oliva, e obesita' centrale

Che ne pensate?
Secondo uno studio pubblicato su Diabetes Care su 11 volontari con 
insulino resistenza, figli di diabetici tipo 2 con obesità centrale, 
quando i soggetti hanno mangiato per 28 gg una dieta ricca di 
carboidrati, la loro massa grassa si è distribuita verso il deposito 
addominale... mentre una dieta ricca di grassi monoinsaturi, a parità 
di calorie, ha prevenuto la distribuzione centrale del grasso, 
associata con l'insulinoresistenza -dice lo studio- attraverso 
meccanismi ancora da chiarire.
"...when patients were fed a CHO-enriched diet, their fat mass was 
redistributed toward the abdominal depot,..."
"An isocaloric MUFA-rich diet prevents central fat redistribution and 
the postprandial decrease in peripheral adiponectin gene expression and 
insulin resistance induced by a CHO-rich diet in insulin-resistant 
subjects."
http://care.diabetesjournals.org/cgi/content/abstract/30/7/1717
Diabetes Care 30:1717-1723, 2007
DOI: 10.2337/dc06-2220
© 2007 by the American Diabetes Association
Clinical Care/Education/Nutrition
Original Article
Monounsaturated Fat–Rich Diet Prevents Central Body Fat Distribution 
and Decreases Postprandial Adiponectin Expression Induced by a 
Carbohydrate-Rich Diet in Insulin-Resistant Subjects
J.A. Paniagua, MD, PHD1,2, A. Gallego de la Sacristana, MD1, I. Romero, 
PHD1, A. Vidal-Puig, MD, PHD3, J.M. Latre, MD, PHD4, E. Sanchez, MD1, 
P. Perez-Martinez, MD, PHD1,2, J. Lopez-Miranda, MD, PHD1,2 and F. 
Perez-Jimenez, MD, PHD1
1 Lipids and Atherosclerosis Research Unit, Reina Sofía University 
Hospital, Córdoba, Spain
2 Ciber Fisiopatología Obesidad y Nutrición (CB06/03), Instituto Salud 
Carlos III, Madrid, Spain
3 Molecular Mechanisms of Energy Balance, Department of Clinical 
Biochemistry, University of Cambridge, Cambridge, U.K.
4 Nuclear Laboratory Service, Reina Sofía University Hospital, Córdoba, 
Spain
Address correspondence and reprint requests to Juan A. Paniagua 
González and F. Pérez Jiménez Unidad de Lípidos y Arteriosclerosis, 
Hospital Universitario Reina Sofía, Avda Menéndez Pidal, s/n 14004, 
Córdoba, Spain. E-mail: 
japan...@yahoo.es
 or 
md1p...@uco.es
OBJECTIVE— Central obesity is associated with insulin resistance 
through factors that are not fully understood. We studied the effects 
of three different isocaloric diets on body fat distribution, insulin 
sensitivity, and peripheral adiponectin gene expression.
RESEARCH DESIGN AND METHODS— Eleven volunteers, offspring of obese type 
2 diabetic patients with abdominal fat deposition, were studied. These 
subjects were considered insulin resistant as indicated by Matsuda 
index values <4 after an oral glucose tolerance test, and they 
maintained A1C <6.5% without therapeutic intervention. All subjects 
underwent three dietary periods of 28 days each in a crossover design: 
1) diet enriched in saturated fat (SAT), 2) diet rich in 
monounsaturated fat (MUFA) (Mediterranean diet), and 3) diet rich in 
carbohydrates (CHOs).
RESULTS— Weight, body composition, and resting energy expenditure 
remained unchanged during the three sequential dietary periods. Using 
dual-energy X-ray absorptiometry we observed that when patients were 
fed a CHO-enriched diet, their fat mass was redistributed toward the 
abdominal depot, whereas periphery fat accumulation decreased compared 
with isocaloric MUFA-rich and high-SAT diets (ANOVA P < 0.05). Changes 
in fat deposition were associated with decreased postprandial mRNA 
adiponectin levels in peripheral adipose tissue and lower insulin 
sensitivity index values from a frequently sampled insulin-assisted 
intravenous glucose tolerance test in patients fed a CHO-rich diet 
compared with a MUFA-rich diet (ANOVA P < 0.05).
CONCLUSIONS— An isocaloric MUFA-rich diet prevents central fat 
redistribution and the postprandial decrease in peripheral adiponectin 
gene expression and insulin resistance induced by a CHO-rich diet in 
insulin-resistant subjects.
Abbreviations: AUC, area under the curve • CHO, carbohydrate • DEXA, 
dual-energy X-ray absorptiometry • MUFA, monounsaturated fat • NEFA, 
nonesterified fatty acid • PUFA, polyunsaturated fat • SAT, saturated 
fat
xpost it-alt.salute.diabete,it.salute.alimentazione


Che sarebbe bello conoscere nei dettagli le 3 diete, una ricca in 
carbo, l'altra in grassi saturi e una in grassi monoinsaturi è un pò 
vago.
-- 
Studentello di Medicina e Chirurgia
Contatti: 
francesc...@gmail.com
  (valida anche per MSN)
Sito: 
http://oneiromancy.altervista.org/

 l'altra in grassi saturi e una in grassi monoinsaturi è un pò vago.
Hai ragionissima! :)