document: ELRs are particularly attractive for the synthesis of block copolymers that self-assemble into polymer nanostructures such as micelles. The first work in this area involved an elastin-mimetic di-block copolymer containing VPGEG–(IPGAG)4 and VPGFG–(IPGVG)4 as the hydrophilic and hydrophobic blocks, respectively [49]. The resulting micelles were studied by dynamic light scattering (DLS) and DSC was used to measure the enthalpy of self-assembly. A tri-block copolymer was subsequently synthesized and the TEM images of this polymer showed that it formed spherical aggregates [50]. Other multivalent spherical micelles have been obtained from linear elastin-like AB di-block copolymers in the temperature range 37–42°C with the aim of targeting cancer cells [51]. Bidwell et al. have also exploited the ELRs for its ability to serve as macromolecular carriers for thermally targeted delivery of drugs. Attachment of doxorubicin to ELR-based system showed enhanced cytotoxicity in uterine sarcoma cells when aggregation was induced with hyperthermia [52].
doc_bio_tags: B O O O O O O O B I O O O B O O O B O O O O O O O O O O O O O O O O O B I I I O O O O B O O O B I I B O B O O O O O O O O O O O O O O O O B I O O B O O O O B I O O O O B O O O O O O O O O O O O O O O O O O B I I O O O O O O O O B O O O O O O B I O B I I I I O O B O O O O O B O B I I O B O O O B O
extractive_keyphrases: aggregation block copolymers cytotoxicity dls doxorubicin dsc dynamic light scattering elrs hydrophilic and hydrophobic blocks hyperthermia macromolecular carriers micelles polymer spherical aggregates targeting cancer cells tem images thermally targeted delivery of drugs uterine sarcoma cells
abstractive_keyphrases: elastin-mimetic di-block copolymer elr-based system linear elastin-like ab di-block copolymers multivalent spherical micelles polymer nanostructures self-assembly synthesis of block copolymers tri-block copolymer vpgeg–(ipgag)4 vpgfg–(ipgvg)4