Patent ID: 12194134

DETAILED DESCRIPTION

The present application will be further described with reference to the accompanying drawings and specific embodiments hereinafter. It should be noted that the embodiments or technical features described hereinafter can be arbitrarily combined to form new embodiments without conflict.

A two-dosage-form essence includes oil gel and hydrogel which are mixed according to a preset ratio during use. The oil gel includes the following components in parts by weight: 0.1-6 parts of active ingredient; 15-35 parts of polyol; 0.1-1 part of SODIUM SURFACTIN; 10-70 parts of oil; and 1-10 parts of water.

SODIUM SURFACTIN is selected as an emulsifier, which comes from nature and is fermented byBacillus subtilis. As shown inFIG.1, it is a circular polypeptide composed of seven amino acids. It is a green and natural polypeptide emulsifier, mild to the skin, has an anti-inflammatory effect, can improve skin permeability and has a very high emulsifying ability. A dosage as low as 0.1% can emulsify 15% or even higher oil.

Water is mainly used to adjust the refractive index of the oil-water phase of the formula.

As a further embodiment, the active ingredient includes 0.1-0.5 part ofLaminaria ochroleucaextract complex, 0.1-0.5 part of algae extract complex, 2-5 parts of complex amino acid, 0.1-1 part of eye circumference mixture. TheLaminaria ochroleucaextract complex is a composition of caprylic/capric triglyceride andLaminaria ochroleucaextract. The algae extract complex is a composition of caprylic/capric triglyceride and algae extract. The complex amino acid is a composition of water, butylene glycol, lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, isoleucine, leucine, tyrosine and phenylalanine. TheLaminaria ochroleucaextract is derived from the “golden seaweed” living in the harsh marine environment. Under the influence of various factors such as the internal and external salinity changes, seawater immersion/non-immersion changes and changes in the intensity of sunlight, theLaminaria ochroleucahas formed a unique survival mechanism. It mainly has active ingredients with comprehensive anti-inflammatory, anti-aging and sun-protection functions.

In addition, the eye circumference mixture is a composition ofCapsicum frutescensfruit extract,Citrus grandis(GRAPEFRUIT) FRUIT EXTRACT,Ruscus aculeatusroot extract,Equisetum arvenseextract,Glycyrrhiza glabra(LICORICE) ROOT EXTRACT/ascorbyl methylsilanol pectinate, methylsilanol hydroxyproline aspartate, dimethylsilanol hyaluronate, aminoethylphosphinic acid, propylene glycol, butylene glycol, methylpropanediol, ethanol, water, PEG-35 castor oil, phenoxyethanol and sodium benzoate.

As a further embodiment, the polyol is one or any combination of glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, and glycereth-26, and preferably glycerin.

As a further embodiment, all the oil comes from natural sources. The oil is any combination ofPrunus amygdalus dulcis(SWEET ALMOND) OIL, Canola oil, C15-19 alkanes,Simmondsia chinensis(JOJOBA) SEED OIL, sunflower seed oil, soybean oil, squalane, octyldodecanol, mineral oil, dimethylsiloxane and cyclomethicone. The ratio of the oil phase may be 10-70%, particularly preferably 40-65%.

As a further embodiment, the oil gel includes the following components in parts by weight: 2-4 parts of active ingredient; 20-30 parts of polyol; 0.1-1 part of SODIUM SURFACTIN; 40-65 parts of oil; 1-10 parts of water; and 0.001-1 part of pigment.

As a further embodiment, the oil gel is prepared by a D-phase emulsification method. The oil gel is obtained by a D-phase emulsification process. With only 0.1-0.5% dosage of emulsifier, up to 50-70% of the oil can be emulsified, and a clear and transparent oil gel can be prepared. If necessary, an anhydrous formula can also be prepared with an emulsion particle size of 2-10 microns.

As a further embodiment, the oil gel further includes 0.001-1 part of pigment.

As a further embodiment, the hydrogel includes the following components in parts by weight: 70-90 parts of water, 3-8 parts of butylene glycol, 3-10 parts of refined peptide complex, 1-5 parts of phytosterols complex, 1-5 parts of glycereth-26, 0.1-1 part of polyacrylate crosspolymer-6, 0.1-0.5 part of xanthan gum, 0.1-1 part of preservative complex, 0.01-0.2 part of PEG-40 hydrogenated castor oil, and 0.01-0.2 part of FRAGRANCE.

As a further embodiment, the refined peptide complex is a composition of water, polysorbate 20, carbomer, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl hexapeptide-8, glycerol and 1,2-hexanediol. The phytosterols complex is a composition of water, propylene glycol and phytosterols. The preservative complex is a combination of phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerin.

The two-dosage-form essence according to the present application is composed of two transparent essences. The oil gel formula is basically of a natural origin and does not contain fragrance preservatives. The oil gel is prepared by the D-phase process with natural fermented SODIUM SURFACTIN as the emulsifier and the natural origin oil as the main body. The hydrogel is a transparent water-soluble gel made from a water-soluble polymer. When in use, the two transparent gels are mixed in a certain ratio and subjected to secondary emulsification to obtain milky white emulsions with different skin feels.

The change process during use is shown inFIGS.2-5.

That is, when in use, the transparent oil gel and the transparent water-based gel (hydrogel) are pumped to the palm of one hand separately and immediately become a milky white emulsion after being mixed by fingers at room temperature to produce a secondary emulsification, which can bring about an instant magic experience to the customer. Due to the high oil phase content of the transparent oil gel, the customer can obtain different types of products by adjusting different dosages of the two transparent gelatins during use. For example, when oil gel:hydrogel is mixed at 1:1, a massage essence can be obtained. When oil gel:hydrogel is mixed at 1:2, moisturizing essence milk can be obtained. When oil gel:hydrogel is mixed in 1:5, it can be used as a body lotion. When oil gel:hydrogel is mixed in 1:20, it can be used as a moisturizer. Therefore, the two-dosage-form essence according to the present application can derive a lot of skin care products, which can greatly streamline the cosmetic bag of the beauty lady during a short business trip or travel, or occasionally use it in emergency.

A method for preparing a two-dosage-form essence includes steps of preparing oil gel and steps of preparing hydrogel.

The steps of preparing the oil gel includes:1) dispersing a formula amount of SODIUM SURFACTIN in a formula amount of polyol, and stirring evenly to obtain an alcohol phase;2) mixing a formula amount of oil evenly to obtain an oil phase;3) adding the oil phase dropwise to the alcohol phase, and stirring evenly to obtain a semi-finished product; and4) adding a formula amount of water and a formula amount of active ingredient to the semi-finished product, and stirring evenly to obtain the oil gel.

The steps of preparing the hydrogel includes: mixing a formula amount of xanthan gum, polyacrylate crosspolymer-6 and water evenly, heating to 80° C. for 10-30 minutes, and then adding a formula amount of refined peptide complex, phytosterols complex and glycereth-26 when the temperature is lowered to 45° C. to obtain a first mixture; then dispersing a formula amount of preservative complex evenly with a formula amount of butylene glycol to obtain a second mixture; dispersing a formula amount of FRAGRANCE evenly with a formula amount of PEG-40 hydrogenated castor oil to obtain a third mixture; and finally, adding the second mixture and the third mixture to the first mixture in sequence, and mixing evenly to obtain the hydrogel.

As a further embodiment, the steps of preparing the oil gel includes:1) dispersing the formula amount of SODIUM SURFACTIN in the formula amount of polyol, and stirring at a speed lower than 600 rpm/min for 5-10 min evenly to obtain the alcohol phase;2) mixing the formula amount of oil evenly to obtain the oil phase;3) adding the oil phase dropwise to the alcohol phase, which should ensure that the oil phase is added slowly before the gel is formed, with a dropping rate of 5-10 g/min and a stirring speed of 500-800 rpm/min, and stirring to form thick gel to obtain the semi-finished product; and4) adding the formula amount of water and the formula amount of active ingredient to the semi-finished product, homogenizing for 2-3 minutes, and stirring evenly to obtain the oil gel. Water is used to adjust the transparency of the product.

The method for preparing a two-dosage-form essence according to the present application is obviously different in the operation process. First, the emulsifier SODIUM SURFACTIN should be evenly dispersed with polyol. Then the oil phase is slowly added dropwise to the polyol+emulsifier phase while stirring at medium speed, and the consistency of the paste will increase significantly during the stirring process. Finally, if necessary, the refractive index of the oil-water phase can be adjusted with a small amount of water to obtain a clear and transparent gel.

Compared with the traditional oil-in-water formulation process, the D-phase emulsification process is significantly different in operation process.

First, the emulsifier SODIUM SURFACTIN should be evenly dispersed with glycerin. Then the oil phase is slowly added dropwise to the glycerin+emulsifier phase while stirring at medium speed, and the consistency of the paste will increase significantly during the stirring process. Finally, if necessary, the refractive index of the oil-water phase can be adjusted with a small amount of water to obtain a clear and transparent gel.

Compared with the traditional oil-in-water formula, the advantages of the D-phase emulsification method are as follows.a. Cold preparation is feasible without heating during the entire production process, which can reduce carbon emissions, shorten production time, and reduce production costs.b. The amount of emulsifier is very low. In this system, only 0.1-0.5% of emulsifier is needed, which greatly reduces the amount of emulsifier and reduces the risk of formula irritation.c. It can emulsify an oil phase with a high oil content. In this system, 40-70% of the oil can be emulsified. In case of an ordinary oil-in-water emulsifier, the oil cannot be emulsified at all with such a low amount of emulsifier.d. The paste has a unique appearance, which can make a very clear and transparent gel, as well as a bright, delicate and translucent paste, and the emulsified particle size of the paste is small, and the material diameter distribution is very uniform.

The following are specific embodiments of the present application. The raw materials, equipment, and the like used in the following embodiments can be obtained through purchase except for special restrictions.

Example 1-7

A two-dosage-form essence includes oil gel and hydrogel. The oil gel and the hydrogel are mixed according to a preset ratio when in use. The oil gel is prepared from the following components: active ingredients, polyols, SODIUM SURFACTIN, oil and water. The hydrogel is prepared from the following components: water, butylene glycol, refined sepin complex (composition of water, polysorbate 20, carbomer, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, acetyl hexapeptide-8, glycerol and 1,2-hexanediol), phytosterols complex (composition of water, propylene glycol and phytosterol), glycerol poly Ether-26, polyacrylate crosspolymer-6, xanthan gum, preservative complex (composition of phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerin), PEG-40 hydrogenated Castor oil, and FRAGRANCE. (The specific formulations of the oil gels of Examples 1-3 are shown in Table 1, and the formulations of the oil gels of Examples 4-7 are consistent with those in Example 1. The specific formulations of the hydrogel of Examples 1-3 are shown in Table 3, and the formulations of the hydrogel of Example 4-7 is shown in Table 4-7. The total amount of components in the same example is 100 parts).

In this application (as in Table 1-7), the raw material connected by “/” means that the raw material is a composite raw material and is a whole.

Comparative Examples 1-6

A two-dosage-form essence includes oil gel and hydrogel. The oil gel and the hydrogel are mixed according to a preset ratio during use. (See Table 1 for the specific formulation of the oil gel, and Table 3 for the specific formulation of the hydrogel. The total amount of components in the same comparative example is 100 parts).

TABLE 1Formulations of the oil gels of Examples 1-3 and Comparative Examples 1-6Compar-Compar-Compar-Compar-Compar-Compar-ativeativeativeativeativeativeExampleExampleexampleexampleexampleexampleexampleexampleRaw materialINCI name1Example3123456PolyolGlycerylGlyceryl30303030303030530PropylenePropylene0000000250GlycolGlycolEmul-KANEKA SFSODIUM0.30.30.50.30.100.30.30.3sifierSURFACTINAMPHISOL KHexadecanyl000001000PhosphatePotassium SaltOilEMOGREENC15-19 alkane27292735272782727L15DW JojobaSIMMONDSIA1111112011ColorlessCHINENSISseed oilCanola OilCanola oil/1820189.81818181818tert-butylhydroquinoneLIPOVOL ALMPRUNUSAMYGDALUS181418181818181818DULCIS oilActiveANTILEUKINECapylic0.30.30.30.30.30.30.30.30.36acid/Caprictriglyceride/LAMINARIAOCHROLEUCAextractJUVENESSENCECapylic/Capric0.20.20.20.20.20.20.20.20.2ADTriglyceride/Algae ExtractAMINO ACODWater/Butylene333333333COMPLEXglycol/Lysine/Histidine/Arginine/Asparticacid/Threonine/Serine/Glutamicacid/Proline/Glycine/Alanine/Valine/IsoleucineAcid/Leucine/Tyrosine/PhenylalanineEXSY 509Y324CAPSICUM0.50.50.50.50.50.50.50.50.5FRUTESCENSfruit extract/CITRUSPARADISI fruitextract/RUSCUSACULEATUSroot extract/EQUISETUMARVENSEextract/GLYCYRRHIZAGLABRAroot extract/Ascorbic acidmethylsilanolpectinate/methylsilanolhydroxyprolineaspartate/dimethylsilanolhyaluronic acidester/aminoethylphosphinicacid/propyleneglycol/butyleneglycol/formalde-hyde Propyleneglycol/ethanol/water/PEG-35castor oil/phenoxyethanol/sodiumbenzoateWaterWaterMarginMarginMarginMarginMarginMarginMarginMarginMarginPigmentq.s.q.s.q.s.q.s.q.s.q.s.q.s.q.s.q.s.StatePastePastePasteSlightlyCannotCannotcold-CannotCannotOKOKOKcloudy,emulsifyemulsifyresistance,emulsifyemulsifynotthinningtranspar-andentunstableenoughDifferenceOptimalIncreaseAdjustReduceChangeChangeReduceChangeratiothethetheto otherthe oilthetheamountamountamountemulsifierwith aamountprocess,ofof oilofhigherofdirectemulsifierphaseemulsifierfreezingglyceryloil-pointwaterphasehomogen-ization

The steps of preparing the oil gels of Examples 1-3 and Comparative Examples 1-5 include:1) dispersing a formula amount of SODIUM SURFACTIN in a formula amount of polyol, and stirring at a speed lower than 600 rpm/min for 5-10 min evenly to obtain an alcohol phase;2) mixing a formula amount of oil evenly to obtain an oil phase;3) adding the oil phase dropwise to the alcohol phase, which should ensure that the oil phase is added slowly before the gel is formed, with a dropping rate of 5-10 g/min and a stirring speed of 500-800 rpm/min, and stirring to form thick gel to obtain a semi-finished product; and4) adding a formula amount of water and a formula amount of active ingredient to the semi-finished product, homogenizing for 2-3 minutes, and stirring evenly to obtain the oil gel.

The preparation process of the oil gel of Comparative Example 6 is changed and the oil gel is directly obtained by homogenizing the oil-water phase.

FIGS.6-14are schematic diagrams of the oil gels of Examples 1-3 and Comparative Examples 1-6, and their formulations and differences in properties are shown in Table 2.

TABLE 2Comparison table of formulations and properties ofoil gels of Examples 1-3 and Comparative Examples 1-6Formula differencedescriptionStateStabilityExampleOptimal ratio (bestClear transparentHeat and cold1example)gelatinresistance OKExampleAdjust the amountClear transparentHeat and cold2of oilgelatinresistance OKExampleIncrease the amountClear transparentHeat and cold3of emulsifiergelatinresistance OKComparativeAdjust the amountSlightly cloudy, notHeat and coldexample 1of oil phasetransparent enoughresistance OKComparativeReduce the amountThe oil phase isUnstable atexampleof emulsifieradded to the glycerylroom2phase. After ⅔ oftemperaturethe oil phase isadded, it cannot beemulsified, and theconsistency will notincrease. After thestirring is stopped,the oil will begin toappear. The upperlayer is transparentliquid, and the lowerlayer is milky white.ComparativeChange to otherThe oil phase isUnstable atexampleemulsifieradded to the glycerylroom3phase. When 50% oftemperaturethe oil phase isadded, it cannot beemulsified.ComparativeChange to oilThe paste is cloudyCold-resistant,examplewith a higherand not transparentthinning and4freezing pointenoughunstableComparativeReduce the amountThe oil phase isOily at roomexampleof glyceryl andadded to the glyceryltemperature5increase the amountphase. It can thickenof propylene glycolat the beginning, andcannot be emulsifiedwhen 50% of the oilphase is added. Thepaste is thin, and theoil will appear atroom temperature forhalf an hourComparativeChange the process,It cannot emulsify atOily at roomexampleand directlyall duringtemperature6homogenize the oil-homogenization, andwater phasethe oil and water willbe separatedimmediately.

The hydrogels of Example 1 and Comparative Examples 1-6 are all prepared according to the formula in Table 3. The preparation process includes:

mixing a formula amount of xanthan gum, polyacrylate crosspolymer-6 and water evenly, heating to 80° C. for 10-30 minutes, and then adding a formula amount of refined peptide complex, phytosterols complex and glycereth-26 when the temperature is lowered to 45° C. to obtain a first mixture; then dispersing a formula amount of preservative complex evenly with a formula amount of butylene glycol to obtain a second mixture; dispersing a formula amount of FRAGRANCE evenly with a formula amount of PEG-40 hydrogenated castor oil to obtain a third mixture; and finally, adding the second mixture and the third mixture to the first mixture in sequence, and mixing evenly to obtain the hydrogel.

TABLE 3Formulations of the hydrogels of Examples 1-3and Comparative Examples 1-6Dosage(byRaw materialweight)INCI nameSupplierASatiaxane ™0.20Xanthan gumCargillVPC 930SEPIMAX ZEN0.35PolyacrylateSEPPICcrosspolymer-6LIPONIC2.0Glyceryl-26VantageBIO EG-1WaterTo100Deionized waterBBPN-tesoro ®5.0Water/polysorbate-United1600 solution20/carbomer/LaboratoriesRefined peptidespalmitoyl tetra-peptide-7/palmitoylpentapeptide-4/acetyl hexapeptide-8/glycerol/1,2-hexanediolREVERSKIN2.0Water/propyleneGREEN-glycol/phytosterolsTECHC1.3-BG5.0Butylene glycolOXEAEUXYL K3500.6Phenoxyethanol/S&MMethylparaben/Ethylparaben/Ethylhexyl glycerylDTAGAT CH400.05PEG-40 hydrogenatedEVONIKcastor oilFlavor 864240490.02FlavorDROM

TABLE 4Formulation of the hydrogel of Example 4DosageRaw material%INCI NameSupplierALiponic ®2.0Glyceryl-26VANTAGEBIO EG-1Butylene glycol5.0Butylene glycolWaterTO100WaterSEPIMAX ZEN0.2Polyacrylate crosspolymer-6SEPPICCarbopol ®0.1Acrylates/C10-30 alklyLubrizolUltrez 21acrylate crosspolymerBTEA0.1TriethanolamineGuangzhouChemicalReagentFactoryMADE-0.2MadecassosideSERDEXCASSOSIDEPONCIRUS1.0Water/glyceryl/PONCIRUSSKEXTRACT (IT)TRIFOLIATA fruit extractBIOLANDIMMORTAL5.0TREMELLA FUCIFORMISSKWA IIextract/Dipropylene glycol/BIOLANDdisodium EDTA/waterULMUS1.0Water/Butylene glycol/SKEXTRACT PFPhenoxyethanol/ULMUSBIOLANDDAVIDIANA root extractEUXYL K3500.5Phenoxyethanol, methyl-S&Mparaben, ethylparaben,ethylhexylglycerylC863991370.008FlavorDROMTAGAT CH400.024PEG-40 hydrogenatedEVONIKcastor oil

The preparation process of the hydrogel of Example 4 includes:1. heating and stirring phase A to fully disperse evenly; and2. after cooling, adding phase B and phase C in sequence, and stirring evenly.

The hydrogel of Example 4 is a light yellow transparent flowing gelatin, with pH=7.29, viscosity=5416 cps (5 #, 5 rpm), stable in heat resistance (48° C. for one month), and stable in cold resistance (−15° C. for one month).

The hydrogel of Example 4 can play a very good anti-allergic effect. The specific principle is as follows.

Main Active Ingredients:

IMMORTAL WA II: It is rich in active ingredients such as carotenoids, flavonoids and polysaccharides (iso-glucan, β-glucan and α-glucan), which can promote the expression of AQP-3 and hyaluronic acid synthase, and has the effects of moisturizing, anti-oxidation and promoting wound healing; in addition, the β-glucan contained therein also has the effects of improving skin immunity and anti-pollution.

PoncirusEXTRACT: It is extracted from the fruit of FructusAurantii, and contains more than 5000 ppm of poncirin. It has anti-allergic and anti-inflammatory effects. It is more effective when combined withPortulaca oleraceaand can protect cells against UVB-induced cell death.

MADECASSOSIDE: It is extracted from wildCentella asiaticagrown in Madagascar and rich in high-purity madecassoside, which can soothe the skin, rebuild extracellular matrix components, anti-inflammatory, regulate and protect the epidermis. In vivo experiments can relieve itching, anti-erythema and improve skin scaling, soothe sensitive skin, atopic dermatitis and psoriasis skin. It is suitable for care products for atopic dermatitis, sensitive and mature skin.

TABLE 5Formulation of the hydrogel of Example 5DosageRaw material%INCI nameSupplierAWaterTo100WaterLIPONIC BIO EG-13.0Glyceryl-26VANTAGESEPIMAX ZEN0.2PolyacrylateSEPPICcrosspolymer-6Carbopol 9410.2Acrylates/C10-30Lubrizolalkly acrylatecrosspolymerNicotinamide2.0NicotinamideMERCKBTEA0.2TriethanolamineGuangzhouChemicalReagentFactoryC1BIO-SODIUM0.03Sodium hyaluronateSKHYALURONATEBIOLANDPOWDER (MMW)MAGNOLIA1.0Water/butylene glycol/SKEXTRACTMAGNOLIABIOLANDSIEBOLDII extractC2SEPIWHITE MSH1.0UndecylenoylSEPPICphenylalanineTEA0.5TriethanolamineGuangzhouChemicalReagentFactoryWater20.0WaterD1,3-Butylene glycol3.01,3-Butylene glycolOXEAEUXYL K3500.5Phenoxyethanol/S&MMethylparaben/Ethylparaben/EthylhexylglycerylEFlavor 864240470.06FlavorDROMTAGAT CH400.18PEG-40 hydrogenatedEVONIKcastor oil

The preparation process of the hydrogel of Example 5 includes:1. heating phase A to swell evenly, adding phase B and stirring to be clear and transparent;2. pre-heating phase C2 and stirring to dissolve to be transparent, and adding phase C to A+B and stirring to disperse evenly; and3. adding pre-dispersed phases D and E, and stirring evenly.

The hydrogel of Example 5 is a transparent flowing liquid, with pH=6.76, stable in heat resistance (48° C. for one month), and stable in cold resistance (−15° C. for one month).

The hydrogel of Example 5 can play a good role in whitening and removing spots. The specific principle is as follows.

Main Active Ingredients:

1. SEPIWHITE MSH: It is an antagonist of the melanocyte-stimulating hormone α-MSH in the process of melanin synthesis. It acts on multiple biochemical reaction stages of melanin formed by α-MSH, thereby comprehensively and effectively inhibiting the production of melanin, and the effect is more obvious and lasting. It can be used in various formulas to make skin clear.2. BIO-SODIUM HYALURONATE POWDER (MMW): It is high-purity, high-quality sodium hyaluronate powder with a molecular weight of 1.3 to 1.8 megadaltons, which can form a viscoelastic, colorless, transparent and non-occlusive film on the skin, thereby having the effect of moisturizing and increasing skin elasticity.3. MAGNOLIAEXTRACT: Because of its elegant appearance, it was once known as the “Heaven Flower” in Korea. It can inhibit the auto-oxidation of dopa, remove free radicals, and can inhibit the pigmentation caused by inflammation or UV irradiation, and has a significant improvement effect on chloasma.

TABLE 6Formulation of the hydrogel of Example 6Raw materialINCI nameSupplierAWaterTO100WaterSatiaxane VPC 9300.18Xanthan gumCargillLiponic ™3.00Glyceryl-26VantageBIO EG-1Carbopol 1 9410.20CarbomerLubrizolBALISTIN1.00Decarboxyl carnosineEXSYMOLHCl/butylene glycol/sodium methyl-paraben/waterBPN-renovarin1.00CarnosineUnitedpowderLaboratoriesCitric acid (20%)0.50Citric acidGuangzhouChemicalReagentFactoryCSETILINE SN0.50TRIGONELLAGreentechFOENUM-GRAECUMseed extractWater15.00WaterDeuxyl K 3500.50Phenoxyethanol/S&MMethylparaben/Ethylparaben/Ethylhexylglyceryl1,3 butylene glycol3.00Butylene glycolTAGAT CH400.15PEG-40 hydrogenatedEVONIKcastor oil864255790.04FlavorDrom

The preparation process of the hydrogel of Example 6 includes:1. heating phase A and stirring evenly, and heating phase C to 80° C. to dissolve and then filtering with filter cloth; and2. stirring to cool phase A to 45° C., adding phases B, C, and D (preservatives in D-phase are pre-dispersed evenly with butylene glycol, and FRAGRANCEs are pre-dispersed evenly with solubilizers), and stirring evenly.

The hydrogel of Example 6 is a light yellow transparent flowing gelatin.

The hydrogel of Example 6 can play a good role in anti-glycation and anti-free radicals. The specific principle is as follows.

Main Active Ingredients:

ALISTIN: It is a multi-effect anti-aging product, innovative in anti-aging and anti-oxidation. The accumulation of oxidation will cause the skin structure to collapse, lose its elasticity, and have wrinkles. ALISTIN not only removes free radicals, but also restores the peroxidized cell membranes, prevents the diffusion of oxidation reactions, and achieves oxidative repair, which neither VE nor VC can do. Glycation will cause protein cross-linking, wrinkles, dull and yellow skin. ALISTIN can not only prevent glycation, but also reverse protein glycation by competing with glycated protein. It is recommended for products for the treatment of aging skin or sun protection and post-sun repair, detoxification and resistance to pigmentation caused by aging. It is also a preferred raw material for improving efficacy in products such as whitening, anti-spot, and anti-hair loss.

SETILINE: It is small molecule galactomannan extracted from the outer skin ofTrigonella foenum-graecumseeds using biotechnology, which can prevent the glycation of collagen and integrin in the dermis, promote the differentiation of epidermal keratinocytes, and increase the thickness of the epidermis, thereby having functions of anti-glycation, anti-aging, anti-wrinkle and improving skin barrier and suitable for anti-wrinkle, anti-aging, firming regeneration and moisturizing products.

BPN-renovarin powder: It is a powerful antioxidant and anti-protein glycation agent that can efficiently capture free radicals in the human body and inhibit the glycosylation and cross-linking reaction of skin proteins, slow down skin aging, and improve skin dullness.

TABLE 7Formulation of the hydrogel of Example 7Raw materialDosage %INCI nameSupplierADEIONIZEDTO100WaterWATERCarbopol 9410.18CarbomerLubrizolSatiaxane VPC9300.08Xanthan gumGARGILLBBPN-CIRUELO2.0Water/polysorbate-United20/glyceryl/1,2-Laboratorieshexanediol/carbomer/palmitoyl tetrapeptide-7GLUCO-0.5GlucosylrutinNanjingSYLRUTINAnyikeTEA0.18TriethanolamineGuangzhouChemicalReagentFactoryEDTA-2NA0.1EDTA-2NAAKZOSOLIBERINE0.5Water/PropyleneGreentechNATGlycol/BUDDLEJAOFFICINALIS ExtractIMMORTAL4.0TREMELLASK BiolandWA IIFUCIFORMIS extract/dipropylene glycol/disodium EDTA/waterCEUXYL K3500.5Phenoxyethanol/S&MMethylparaben/Ethylparaben/EthylhexylglycerylPropylene Glycol8.0Propylene GlycolButylene glycol5.0Butylene glycolOXEAD863001850.1FlavorDromTAGAT CH400.3PEG-40 hydrogenatedEvoniccastor oil

The preparation process of the hydrogel of Example 7 includes:

dispersing phase A evenly, and then adding phases B, C and D and stirring evenly.

The hydrogel of Example 7 is a yellow liquid, with PH=5.83 (10% aqueous solution), viscosity=1485 cps (3 #20′), stable in heat resistance (48° C. for one month), and state in cold resistance (−15° C. for one month).

The hydrogel of Example 7 can play a very good anti-blue light effect, and the specific principle is as follows.

Main Active Ingredients:

1. BPN-CIRUELO: It can significantly reduce the level of inflammatory factors interleukin, thereby eliminating potential inflammation of the skin, restoring skin health, and reducing the damage of inflammation to the skin.2. GLUCOSYLRUTIN: Glucosylrutin as a strong antioxidant, combined with the characteristics of UV absorption, can protect the epidermis and dermis from UV damage, so that the skin will no longer be troubled by such effects.3. SOLIBERINE NAT: Derived from plateau plantBuddleja officinalis, it can resist strong sunlight radiation in plateau areas, and at the same time resist blue, infrared and ultraviolet light damage to the skin, inhibiting and repairing the occurrence of damage at various key points of light damage.
Effect Evaluation and Performance Testing
1. Moisture Retention Test
(1) Test Description

Cumulative sample N=20 (sample amount to achieve T test)

Test object: to test the moisture retention of the hydrogel alone used in the two-dosage-form essence of Example 1 of the present application and the moisture retention of using different ratios of oil gel to verify that the oil gel can improve the moisture retention of the hydrogel.

Test method: 20 volunteers between the ages of 26-45 applied 0.04 μL of samples A, B, and C on the inside of one arm in a single application, and subjected to skin moisture content measurement with CK (Derma-Expert MC760) before applying and 1 h and 2 h after applying.

Testing Samples:

A: Hydrogel (Example 1)B: Hydrogel (Example 1): Oil gel (Example 1)=4:1C: Hydrogel (Example 1): Oil gel (Example 1)=1:1
(2) Test Environment

A blank control group is set up to test the influence of the external environment on the moisture retention test.

1 h VS blank; 2 h VS 1 h; 2 h VS blank.

(3) Test results (as shown inFIG.15-20)

1. Samples A, B and C all have instant and long-lasting moisturizing effects;2. Sample C has the best instant and long-lasting moisturizing effect;3. The oil gel can effectively improve the moisture retention of the hydrogel; and4. The combination of the hydrogel and the oil gel has good moisturizing effect.

The above embodiments are merely preferred embodiments of the present application, and shall not be used to limit the scope of protection of the present application. Any insubstantial changes and substitutions made by those skilled in the art on the basis of the present application belong to the scope of protection of the present application.