A crossflow membrane separation system comprising: a membrane vessel housing a membrane element , wherein the membrane vessel has a vertical orientation; a vessel retentate inlet that provides a retentate from a vessel feed line directly into a retentate side of the vertically oriented membrane vessel , wherein the retentate side is a top portion of the membrane vessel , wherein the vessel feed line receives the retentate from a pump and comprises a raw product and infeed valve , an air-blow valve , fluidly connected to an air shutoff valve , and a line block valve ; a back pressure control valve adjusted to remove permeate from the retentate to a permeate side of the vertically oriented vessel through the membrane element ; a vessel retentate outlet associated with a retentate outlet valve and a vessel permeate outlet associated with a permeate outlet valve , each removing the retentate and the permeate from the vessel , respectively; and a permeate side air inlet configured on a top end of the vertically oriented vessel that receives air from a permeate air control valve , wherein permeate and retentate air inlets are configured to supply air that scavenges remaining retentate, permeate or chemical residues from the membrane element , and further wherein the permeate side air inlet and the retentate air inlet are each configured to provide air pressure to the vessel such that a pressure in the retentate side is continuously greater than or equal to a pressure on the permeate side, wherein the retentate side air inlet receives air from the vessel feed line , and the permeate side air inlet is downstream of the retentate side air inlet , and is fluidly connected to it by the permeate air control valve . a membrane vessel housing a membrane element , wherein the membrane vessel has a vertical orientation; a vessel retentate inlet that provides a retentate from a vessel feed line directly into a retentate side of the vertically oriented membrane vessel , wherein the retentate side is a top portion of the membrane vessel , wherein the vessel feed line receives the retentate from a pump and comprises a raw product and infeed valve , an air-blow valve , fluidly connected to an air shutoff valve , and a line block valve ; a back pressure control valve adjusted to remove permeate from the retentate to a permeate side of the vertically oriented vessel through the membrane element ; a vessel retentate outlet associated with a retentate outlet valve and a vessel permeate outlet associated with a permeate outlet valve , each removing the retentate and the permeate from the vessel , respectively; and a permeate side air inlet configured on a top end of the vertically oriented vessel that receives air from a permeate air control valve , wherein permeate and retentate air inlets are configured to supply air that scavenges remaining retentate, permeate or chemical residues from the membrane element , and further wherein the permeate side air inlet and the retentate air inlet are each configured to provide air pressure to the vessel such that a pressure in the retentate side is continuously greater than or equal to a pressure on the permeate side, wherein the retentate side air inlet receives air from the vessel feed line , and the permeate side air inlet is downstream of the retentate side air inlet , and is fluidly connected to it by the permeate air control valve . <EOS>