mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody comprising a light chain variable region comprising three complementarity determining regions set forth as SEQ ID NOs: 6, 7 and 8, and a heavy chain variable region comprising three complementarity determining regions set forth as SEQ ID NOs: 9, 10 and 11 for use in a method: (A) of treating peripheral neuropathy in a patient with peripheral neuropathy associated with AL amyloidosis; or (B) of independently treating peripheral neuropathy in a patient with AL amyloidosis, wherein: (a) the patient presents with peripheral neuropathy; (b) the patient has not shown any cardiac response to an effective dosage of the antibody when previously administered; (c) the patient has not shown any renal response to an effective dosage of the antibody when previously administered; (d) the patient previously received treatment with a different agent that did not affect the patient's peripheral neuropathy; and/or (e) the patient is receiving treatment with a different agent that does not affect the patient's peripheral neuropathy; and further wherein SEQ ID NOs: 6, 7, 8, 9, 10 and 11 have the following sequences (using single letter amino acid codes): RSSQSLVHSTGNTYLH, KVSNRFS, SQSTHVPFT, GFTFNTYAMY, RIRSKSNNYAIYYADSVKD and PYSDSFAY, respectively. (A) of treating peripheral neuropathy in a patient with peripheral neuropathy associated with AL amyloidosis; or (B) of independently treating peripheral neuropathy in a patient with AL amyloidosis, wherein: (a) the patient presents with peripheral neuropathy; (b) the patient has not shown any cardiac response to an effective dosage of the antibody when previously administered; (c) the patient has not shown any renal response to an effective dosage of the antibody when previously administered; (d) the patient previously received treatment with a different agent that did not affect the patient's peripheral neuropathy; and/or (e) the patient is receiving treatment with a different agent that does not affect the patient's peripheral neuropathy; and further wherein SEQ ID NOs: 6, 7, 8, 9, 10 and 11 have the following sequences (using single letter amino acid codes): RSSQSLVHSTGNTYLH, KVSNRFS, SQSTHVPFT, GFTFNTYAMY, RIRSKSNNYAIYYADSVKD and PYSDSFAY, respectively. (a) the patient presents with peripheral neuropathy; (b) the patient has not shown any cardiac response to an effective dosage of the antibody when previously administered; (c) the patient has not shown any renal response to an effective dosage of the antibody when previously administered; (d) the patient previously received treatment with a different agent that did not affect the patient's peripheral neuropathy; and/or (e) the patient is receiving treatment with a different agent that does not affect the patient's peripheral neuropathy; and further wherein SEQ ID NOs: 6, 7, 8, 9, 10 and 11 have the following sequences (using single letter amino acid codes): RSSQSLVHSTGNTYLH, KVSNRFS, SQSTHVPFT, GFTFNTYAMY, RIRSKSNNYAIYYADSVKD and PYSDSFAY, respectively.
Installation module for installing at least one domestic appliance in at least one furniture body , the installation module comprising at least one housing device having at least two walls which delimit at least one receiving compartment for the at least one domestic appliance at least in portions, at least one outer dimension of the housing device being adapted to at least one inner dimension of at least one opening of the at least one furniture body , at least one wall of the housing device being designed as a door compartment having at least one forwardly directed opening , at least one door support unit , which is movable at least in portions, for receiving at least one furniture front being arranged in the door compartment , characterised in that the housing device is designed to be foldable at least in portions. the installation module comprising at least one housing device having at least two walls which delimit at least one receiving compartment for the at least one domestic appliance at least in portions, at least one outer dimension of the housing device being adapted to at least one inner dimension of at least one opening of the at least one furniture body , at least one wall of the housing device being designed as a door compartment having at least one forwardly directed opening , at least one door support unit , which is movable at least in portions, for receiving at least one furniture front being arranged in the door compartment , characterised in that the housing device is designed to be foldable at least in portions.
A connection pin comprising a first contact part that is adapted for mounting in a hole in a printed circuit board (PCB) by soldering to an inner wall of the hole in the printed circuit board, and a second contact part , wherein the first contact part comprises a cavity surrounded by a wall , wherein the wall has at least one opening , and wherein at least one solder preform is located in the cavity , characterized in that the connection pin has an open end located at the end of the connection pin that is closest to the first contact part , and that an opening provided by the open end communicates with the cavity .
A sliding member comprising: a sliding surface against which an outer surface of a cam abuts; and a groove having a spiral shape or a plurality of grooves having an annular shape, which are provided on the sliding surface, characterized in that the sliding surface comprises a central region having a circular shape and including a center of the sliding surface, and a first annular region located outside the central region, and a ratio R C of a width L2 of the groove to a pitch L1 of the groove in the central region is larger than a ratio R O1 of the width L2 of the groove to the pitch L1 of the groove in the first annular region. a sliding surface against which an outer surface of a cam abuts; and a groove having a spiral shape or a plurality of grooves having an annular shape, which are provided on the sliding surface, characterized in that the sliding surface comprises a central region having a circular shape and including a center of the sliding surface, and a first annular region located outside the central region, and a ratio R C of a width L2 of the groove to a pitch L1 of the groove in the central region is larger than a ratio R O1 of the width L2 of the groove to the pitch L1 of the groove in the first annular region.
A xylanase variant, comprising a substitution at one or more positions corresponding to positions 24, 26, 36, 37, 60, 71, 74, 75, 76, 124, 133, 155, 167, 208, 317, and 321 of SEQ ID NO: 1, wherein the substitution is selected from the group consisting of H24W, A26E, R36L, R36T, E37T, R60N, K71T, K71I, V74L, V74I, K75N, K75L, H76L, I155M, N167E, V208L, S317D and G321A, wherein the xylanase variant has xylanase activity and wherein the xylanase variant has at least 90%, but less than 100% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5 or 6, and wherein the variant has improved thermostability compared to one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, or SEQ ID NO: 6.
A cluster composition which comprises a suspension of clusters in an aqueous biocompatible medium, where said clusters have a diameter in the range 1 to 10 μm, and a circularity < 0.9 and comprise: (i) a first component which comprises a gas microbubble and first stabilizer to stabilize said microbubble, wherein the gas of the gas microbubble comprises sulphur hexafluoride, a C 3-6 perfluorocarbon, nitrogen, air or mixtures thereof; and (ii) a second component which comprises a microdroplet comprising an oil phase and a second stabilizer to stabilize said microdroplet, where the oil comprises a diffusible component capable of diffusing into said gas microbubble so as to at least transiently increase the size thereof, and wherein the oil phase comprises a partly or fully halogenated hydrocarbon or a mixture thereof, where said second component further comprises a first therapeutic agent; where the microbubbles and microdroplets of said first and second components have opposite surface charges and form said clusters via attractive electrostatic interactions, where the first stabilizer and the second stabilizer each have a net electrostatic charge that is opposite to that of the other, and wherein the first stabilizer and the second stabilizer each independently comprises a phospholipid, a protein, or a polymer. (i) a first component which comprises a gas microbubble and first stabilizer to stabilize said microbubble, wherein the gas of the gas microbubble comprises sulphur hexafluoride, a C 3-6 perfluorocarbon, nitrogen, air or mixtures thereof; and (ii) a second component which comprises a microdroplet comprising an oil phase and a second stabilizer to stabilize said microdroplet, where the oil comprises a diffusible component capable of diffusing into said gas microbubble so as to at least transiently increase the size thereof, and wherein the oil phase comprises a partly or fully halogenated hydrocarbon or a mixture thereof, where said second component further comprises a first therapeutic agent; where the microbubbles and microdroplets of said first and second components have opposite surface charges and form said clusters via attractive electrostatic interactions, where the first stabilizer and the second stabilizer each have a net electrostatic charge that is opposite to that of the other, and wherein the first stabilizer and the second stabilizer each independently comprises a phospholipid, a protein, or a polymer.
A polishing composition for polishing silicon wafer, the polishing composition comprising an abrasive, a water-soluble polymer and water, wherein the abrasive consists of silica grains, the average secondary particle diameter D P2 of the silica grains being 20 nm to 100 nm, measured on an aqueous dispersion of the silica grains by dynamic light scattering, and wherein the water-soluble polymer satisfies the following conditions: the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic. wherein the abrasive consists of silica grains, the average secondary particle diameter D P2 of the silica grains being 20 nm to 100 nm, measured on an aqueous dispersion of the silica grains by dynamic light scattering, and wherein the water-soluble polymer satisfies the following conditions: the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic. the water-soluble polymer comprises a vinyl alcohol unit as a hydroxyl groupcontaining repeat unit; the water-soluble polymer comprises a repeat unit B having an SP value of lower than 14.5, the water-soluble polymer has a hydroxyl group content in a range of 4 mmol/g or higher, but 21 mmol/g or lower; the water-soluble polymer has a weight average molecular weight of 1 × 10 4 or larger; and the water-soluble polymer is nonionic.
An apparatus for receiving and supporting one or more components during processing thereof at a process temperature greater than approximately 1000°C, the apparatus comprising a first shelf , a plurality of first support posts and a second shelf , the first shelf (i) comprising a first refractory metal having a melting point greater than the process temperature and (ii) defining therethrough a plurality of apertures, each aperture being threaded through at least a portion of its thickness, each first support post comprising a second refractory metal having a melting point greater than the process temperature, and the second shelf (i) comprising a third refractory metal having a melting point greater than the process temperature and (ii) defining therethrough a plurality of apertures, characterized in that each first support post has a threaded lower end for engagement with a threaded aperture of the first shelf , and defines a support collar proximate an upper end opposite the threaded lower end , a lateral dimension of the first support post above the support collar being smaller than a lateral dimension of the first support post below the support collar ; and each aperture of the second shelf is configured to receive the upper end of one of the lower support posts such that a portion of the second shelf proximate each aperture thereof rests upon the support collar of the first support post received in the aperture.
A policy update method performed by an access and mobility management network element, the method comprising: • receiving updated policy information of a local area data network, LADN, and instruction information from a policy control network element , o wherein the updated policy information is an updated user equipment route selection policy and contains identification information of the LADN, and o the instruction information is used to instruct the access and mobility management network element to update the updated policy information regionally with respect to a service area of the LADN; • determining the service area of the LADN according to a correspondence between the service area of the LADN and the identification information of the LADN ; • determining whether a terminal device is within the service area of the LADN; • in case the terminal device is within the service area, sending the updated policy information to the terminal device in the service area of the LADN according to the instruction information, thereby regionally updating the updated policy information . • receiving updated policy information of a local area data network, LADN, and instruction information from a policy control network element , o wherein the updated policy information is an updated user equipment route selection policy and contains identification information of the LADN, and o the instruction information is used to instruct the access and mobility management network element to update the updated policy information regionally with respect to a service area of the LADN; o wherein the updated policy information is an updated user equipment route selection policy and contains identification information of the LADN, and o the instruction information is used to instruct the access and mobility management network element to update the updated policy information regionally with respect to a service area of the LADN; • determining the service area of the LADN according to a correspondence between the service area of the LADN and the identification information of the LADN ; • determining whether a terminal device is within the service area of the LADN; • in case the terminal device is within the service area, sending the updated policy information to the terminal device in the service area of the LADN according to the instruction information, thereby regionally updating the updated policy information .
An air turbine starter for starting an engine , comprising: a starter housing defining an inlet , an outlet , and a flow path extending between the inlet and the outlet ; and a turbine section located within the starter housing for rotatably extracting mechanical power from a flow of gas through the flow path , the turbine section comprising: a turbine member comprising a central disk and a set of airfoils spaced circumferentially about the central disk ; a sealing structure located within the starter housing ; and a fastener closing the sealing structure , the fastener comprising a threaded bolt with a first end comprising a head with a cutting face confronting the central disk of the turbine member . a starter housing defining an inlet , an outlet , and a flow path extending between the inlet and the outlet ; and a turbine section located within the starter housing for rotatably extracting mechanical power from a flow of gas through the flow path , the turbine section comprising: a turbine member comprising a central disk and a set of airfoils spaced circumferentially about the central disk ; a sealing structure located within the starter housing ; and a fastener closing the sealing structure , the fastener comprising a threaded bolt with a first end comprising a head with a cutting face confronting the central disk of the turbine member . a turbine member comprising a central disk and a set of airfoils spaced circumferentially about the central disk ; a sealing structure located within the starter housing ; and a fastener closing the sealing structure , the fastener comprising a threaded bolt with a first end comprising a head with a cutting face confronting the central disk of the turbine member .
An inhibitor of adrenomedullin or an inhibitor of adrenomedullin receptors for use in the prevention and treatment of diseases that reduce bone density in a human or animal, characterized in that said inhibitor is selected from the group consisting of the compounds of formula: or is an interference RNA molecule, which comprises a sequence complementary to SEQ ID NO: 2 or SEQ ID NO: 3.
An apparatus for use in a Neighborhood Awareness Network, NAN, device, the apparatus comprising: a memory ; and processing circuitry in communication with the memory and arranged to: generate, for transmission to another NAN device, a Neighborhood Awareness Network, NAN, public action frame comprising an indication that the NAN public action frame is a schedule update frame and a change in a schedule of at least one of time blocks or one or more channels for communication between the NAN device and the other NAN device, wherein the change is selectable from a plurality of different changes to the time blocks including changes to a current time block and at least one of future time blocks or one or more channels; and adjust the schedule as indicated by the schedule update frame to change communication with the other NAN device. a memory ; and processing circuitry in communication with the memory and arranged to: generate, for transmission to another NAN device, a Neighborhood Awareness Network, NAN, public action frame comprising an indication that the NAN public action frame is a schedule update frame and a change in a schedule of at least one of time blocks or one or more channels for communication between the NAN device and the other NAN device, wherein the change is selectable from a plurality of different changes to the time blocks including changes to a current time block and at least one of future time blocks or one or more channels; and adjust the schedule as indicated by the schedule update frame to change communication with the other NAN device. generate, for transmission to another NAN device, a Neighborhood Awareness Network, NAN, public action frame comprising an indication that the NAN public action frame is a schedule update frame and a change in a schedule of at least one of time blocks or one or more channels for communication between the NAN device and the other NAN device, wherein the change is selectable from a plurality of different changes to the time blocks including changes to a current time block and at least one of future time blocks or one or more channels; and adjust the schedule as indicated by the schedule update frame to change communication with the other NAN device.
Method of production of a seamless high-pressure steel cylinder , where the cylinder is made in the first step by backwards extrusion process, when first the bottom is produced by using of a shaped punching head, wherein the head has a bigger outer diameter and the die has greater inner diameter than the final dimensions are, and afterwards the broaching with monolitic pressing mandrel provided with the shaped end is done, which has the same form of the bottom surface as the shaped punching head, characterized in, that on the outer surface of the shaped punching head a cavity for creating of the inner material strengthening of the bottom of the high-pressure steel cylinder is created and the backwards extrusion using such modified shaped punching head is done, afterwords in the subsequent step the backwards extrusion process with monolitic pressing mandrel is done, the mandrel is provided by the shaped end provided with the cavity , wherein the rest of the high-pressure steel cylinder is made by the known method and in the end the inner material strenghtening on the bottom of the high-pressure steel cylinder is drilled through and so the through-out bottom neck is created, the method resulting in a high-pressure steel cylinder with an upper neck on the rounded end, which protrudes from the cylinder and is provided with an opening, the high-pressure steel cylinder being additionally provided on its bottom with another bottom neck made in an inner material strengthening which is orientated insidewards of the high-pressure steel cylinder , and the inner material strengthening is provided with a through-out-opening.
Operating method for a device which has a diesel engine having a crankshaft and a plurality of cylinders and an exhaust gas post-treatment system, wherein a fuel injection into at least one of the cylinders (Z) is shut down (S1) when required and the at least one shut-down cylinder (Z) is set to a braking mode (S2) such that, in particular, the temperature of the exhaust gas for the exhaust gas post-treatment system can be increased, wherein: controlling the temperature of the exhaust gas for the exhaust gas post-treatment system comprises two degrees of freedom, specifically shutting down the fuel injection into at least one of the cylinders (Z) and setting the at least one shut-down cylinder (Z) to the braking mode; and setting the at least one shut-down cylinder (Z) to the braking mode is accomplished by means of a cam contour device. controlling the temperature of the exhaust gas for the exhaust gas post-treatment system comprises two degrees of freedom, specifically shutting down the fuel injection into at least one of the cylinders (Z) and setting the at least one shut-down cylinder (Z) to the braking mode; and setting the at least one shut-down cylinder (Z) to the braking mode is accomplished by means of a cam contour device.
A cable duct with a cable duct tray , a cable duct lid that can be walked on made of a sheet metal strip with two longitudinal edges, and at least one fastener for mounting the cable duct lid to the cable duct tray , wherein the cable duct lid that can be walked on comprises: (i) a cover member having an upper surface and a lower surface, and (ii) two lateral parts protruding from the cover member , said lateral parts each forming a lateral edge of the cable duct lid and being formed by bending both longitudinal edges downwards away from the upper surface, wherein the upper surface of the cover member comprises a structured central region that is formed by way of embossing from the lower surface and provides a slip-resistant surface, and wherein the upper surface of the cover member comprises a non-structured periphery with a width (b) of between 5 mm and 50 mm on both sides of the structured central region towards the respective lateral edge. (i) a cover member having an upper surface and a lower surface, and (ii) two lateral parts protruding from the cover member , said lateral parts each forming a lateral edge of the cable duct lid and being formed by bending both longitudinal edges downwards away from the upper surface, wherein the upper surface of the cover member comprises a structured central region that is formed by way of embossing from the lower surface and provides a slip-resistant surface, and wherein the upper surface of the cover member comprises a non-structured periphery with a width (b) of between 5 mm and 50 mm on both sides of the structured central region towards the respective lateral edge.