A system for applying a mechanical strain to a portion of skin, said system including an appliance and an end effector , said appliance including: a drive motor assembly , a drive motor , a drive shaft or mounting arm , a drive control , a power storage source , wherein said drive control is configured and arranged to selectively deliver power from the power storage source to the drive motor assembly , wherein said drive control includes a power adjust or mode control button coupled to control circuitry, such as a programmed microcontroller or processor, which is configured to control the delivery of power to the drive motor assembly , wherein the drive motor is configured to drive the end effector , and thus to impart oscillatory motion at an oscillation frequency to the end effector in a first rotational direction and a second rotational direction, wherein the end effector includes a plurality of contact points being the first portions to contact the portion of skin as the end effector is lowered to a portion of skin to be treated with the end effector , characterized in that the contact points on the end effector are equidistantly positioned at a target distance , where the target distance is calculated based on the equation target distance 106 = n × propagation speed target frequency where the propagation speed equals 2 meters per second and the target frequency is a desired oscillation frequency of the end effector at which the oscillatory motion is imparted to the end effector and a cyclical response within a portion of the skin is to be induced, and n is an integer, and where the target frequency is in particular in a range from about 30 Hz to about 140 Hz, the appliance further includes a user-activated input configured to activate the end effector to act as cyclical mechanical strain component for a predetermined treatment time period at the oscillation frequency. a drive motor assembly , a drive motor , a drive shaft or mounting arm , a drive control , a power storage source , wherein said drive control is configured and arranged to selectively deliver power from the power storage source to the drive motor assembly , wherein said drive control includes a power adjust or mode control button coupled to control circuitry, such as a programmed microcontroller or processor, which is configured to control the delivery of power to the drive motor assembly , wherein the drive motor is configured to drive the end effector , and thus to impart oscillatory motion at an oscillation frequency to the end effector in a first rotational direction and a second rotational direction, wherein the end effector includes a plurality of contact points being the first portions to contact the portion of skin as the end effector is lowered to a portion of skin to be treated with the end effector , characterized in that the contact points on the end effector are equidistantly positioned at a target distance , where the target distance is calculated based on the equation target distance 106 = n × propagation speed target frequency where the propagation speed equals 2 meters per second and the target frequency is a desired oscillation frequency of the end effector at which the oscillatory motion is imparted to the end effector and a cyclical response within a portion of the skin is to be induced, and n is an integer, and where the target frequency is in particular in a range from about 30 Hz to about 140 Hz, the appliance further includes a user-activated input configured to activate the end effector to act as cyclical mechanical strain component for a predetermined treatment time period at the oscillation frequency. <EOS>