A core-shell polymeric scaffold comprising: a core component having a first porosity; and a shell component surrounding the core component and having a second porosity, the second porosity differing from the first porosity, wherein the core component comprises a first polymer network formed from one or more monomers of Formula (A); one or more monomers of Formula (B1), (B2), or (B3); one or more monomers comprising an alkyne moiety; and one or more monomers comprising an azide moiety: and wherein R 1 , R 2 , and R 3 are independently -H, -CH 3 , -CH 2 CH 3 , or M + ; R 4 is -H; R 5 is -H, -OH, -OCH 3 , -OCH 2 CH 3 , -CH 3 , -CH 2 CH 3 , -NH 2 , NHCH 3 , -CH 2 CH 2 NHCH 3 , -N(CH 3 ) 2 , or -CH 2 CH 2 N(CH 2 CH 3 ) 2 ; R 6 is -H, -CH 3 , or -CH 2 CH 3 , -(CH 3 ) 2 , or -(CH 2 CH 3 ) 2 ; R 7 is -H or -CH 3 ; R 8 is -(CH 2 ) a -, -(CH 2 CH 2 O) b -, or -(CH 2 OCH 2 ) b -; R 9 is -H, -CH 3 , or a C2-C20 alkyl; R 10 is -H, -C(O)CH 3 , or -C(O)CH 2 CH 3 ; R 11 and R 12 are independently -OH or -NH 2 ; M + is a monovalent cation; X and Y are independently -O- or -NH-; Z is -H, -CH 3 , -(CH 3 ) 2 , -(CH 2 CH 3 ) 2 , or a is an integer from 0 to 20; b is an integer from 0 to 2000; n is an integer between 1 and 2000; and m and p are independently integers ranging from 1 to 20; and wherein the monomer of Formula (B1) has at least one terminus comprising -OH or -NH 2 ; and wherein the shell component comprises a second polymer network formed from one or more monomers of Formula (A); one or more monomers of Formula (B1), (B2), or (B3); one or more monomers comprising an alkyne moiety; and one or more monomers comprising an azide moiety. a core component having a first porosity; and a shell component surrounding the core component and having a second porosity, the second porosity differing from the first porosity, wherein the core component comprises a first polymer network formed from one or more monomers of Formula (A); one or more monomers of Formula (B1), (B2), or (B3); one or more monomers comprising an alkyne moiety; and one or more monomers comprising an azide moiety: and wherein R 1 , R 2 , and R 3 are independently -H, -CH 3 , -CH 2 CH 3 , or M + ; R 4 is -H; R 5 is -H, -OH, -OCH 3 , -OCH 2 CH 3 , -CH 3 , -CH 2 CH 3 , -NH 2 , NHCH 3 , -CH 2 CH 2 NHCH 3 , -N(CH 3 ) 2 , or -CH 2 CH 2 N(CH 2 CH 3 ) 2 ; R 6 is -H, -CH 3 , or -CH 2 CH 3 , -(CH 3 ) 2 , or -(CH 2 CH 3 ) 2 ; R 7 is -H or -CH 3 ; R 8 is -(CH 2 ) a -, -(CH 2 CH 2 O) b -, or -(CH 2 OCH 2 ) b -; R 9 is -H, -CH 3 , or a C2-C20 alkyl; R 10 is -H, -C(O)CH 3 , or -C(O)CH 2 CH 3 ; R 11 and R 12 are independently -OH or -NH 2 ; M + is a monovalent cation; X and Y are independently -O- or -NH-; Z is -H, -CH 3 , -(CH 3 ) 2 , -(CH 2 CH 3 ) 2 , or a is an integer from 0 to 20; b is an integer from 0 to 2000; n is an integer between 1 and 2000; and m and p are independently integers ranging from 1 to 20; and wherein the monomer of Formula (B1) has at least one terminus comprising -OH or -NH 2 ; and wherein the shell component comprises a second polymer network formed from one or more monomers of Formula (A); one or more monomers of Formula (B1), (B2), or (B3); one or more monomers comprising an alkyne moiety; and one or more monomers comprising an azide moiety. <EOS>