mhurhangee/patent-ind-claim-en huggingface dataset:
A method of formulating polymer microparticles for the controlled release of botulinum toxin, comprising the steps of: (a) dissolving the botulinum toxin and a bulking agent protein in an aqueous solution to form a botulinum toxin-protein solution; (b) precipitating the botulinum toxin-protein from the solution with a precipitating agent selected from the group consisting of L-histidine methyl ester, L-cysteine ethyl ester, Na-(tert-butoxycarbonyl)-L-asparagine, L-proline benzyl ester, N-acetyl-L-tryptophan, gentisic acid, pentetic acid, octanoic acid, zinc chloride, and combinations thereof, to form a precipitant; (c) washing the precipitant one or more times with a wash solvent to form a solvent-washed precipitant; (d) mixing or dispersing the precipitant in a solution of a polymer to form a polymer-botulinum toxin-protein dispersion; and (e) preparing polymer microparticles encapsulating the botulinum toxin-protein from the polymer-botulinum toxin-protein dispersion. (a) dissolving the botulinum toxin and a bulking agent protein in an aqueous solution to form a botulinum toxin-protein solution; (b) precipitating the botulinum toxin-protein from the solution with a precipitating agent selected from the group consisting of L-histidine methyl ester, L-cysteine ethyl ester, Na-(tert-butoxycarbonyl)-L-asparagine, L-proline benzyl ester, N-acetyl-L-tryptophan, gentisic acid, pentetic acid, octanoic acid, zinc chloride, and combinations thereof, to form a precipitant; (c) washing the precipitant one or more times with a wash solvent to form a solvent-washed precipitant; (d) mixing or dispersing the precipitant in a solution of a polymer to form a polymer-botulinum toxin-protein dispersion; and (e) preparing polymer microparticles encapsulating the botulinum toxin-protein from the polymer-botulinum toxin-protein dispersion.
A computer-implemented method for manipulating three-dimensional modeled objects of an assembly in a three-dimensional scene, comprising the steps of: - determining at least a first set of at least one object and a second set of at least one object among said three-dimensional modeled objects of the assembly; - grouping the at least one object of the first set in a first parallelepiped three-dimensional bounding box (BB) and the at least one object of the second set in a second parallelepiped three-dimensional bounding box (BB); and - relatively reorganizing the bounding boxes (BB), wherein the step of reorganizing the bounding boxes (BB) comprises a changing of the content of the set of objects of the bounding boxes (BB), wherein said changing of the content of the set of objects of a bounding box (BB) uses at least one selectable content area (SCA) of the surface of the bounding box (BB), the selectable content area (SCA) being a part of a face of the bounding box (BB) which is a control to add objects of the assembly to the bounding box (BB). - determining at least a first set of at least one object and a second set of at least one object among said three-dimensional modeled objects of the assembly; - grouping the at least one object of the first set in a first parallelepiped three-dimensional bounding box (BB) and the at least one object of the second set in a second parallelepiped three-dimensional bounding box (BB); and - relatively reorganizing the bounding boxes (BB),
A spring failure detection system comprising: an air brake cylinder with a spring axially extending therein, wherein failure of the spring creates a spring failure impact force that is applied to the air brake cylinder ; a sensor coupled to the air brake cylinder and configured to sense forces applied to the air brake cylinder ; and an indicator configured to indicate failure of the spring when at least one of the forces sensed by the sensor is equal to or greater than the spring failure impact force. an air brake cylinder with a spring axially extending therein, wherein failure of the spring creates a spring failure impact force that is applied to the air brake cylinder ; a sensor coupled to the air brake cylinder and configured to sense forces applied to the air brake cylinder ; and an indicator configured to indicate failure of the spring when at least one of the forces sensed by the sensor is equal to or greater than the spring failure impact force.
A method for producing a random polymer; said method comprising steps of: (a) polymerizing a first monomer composition comprising from 90 to 100 wt% C 3 -C 6 carboxylic acid monomer in an initial polymerization phase; and (b) polymerizing a second monomer composition comprising from 30 to 80 wt% C 3 -C 6 carboxylic acid monomer and from 20 to 70 wt% sulfonic acid monomer in a second polymerization phase; wherein a chain transfer agent is added during addition of the first and second monomer compositions; and wherein the chain transfer agent is added with monomers continuously over the entire monomer addition time.
A method for retrieving data indicative of a graphical user interface configuration of a target universal remote controlling device, characterised by comprising: receiving at a centralized server device from a configuration editing system in communication with the centralized server device via a network an upload request for retrieving the graphical user interface configuration of the target universal remote controlling device , wherein the upload request specifies an address associated with the target universal remote controlling device ; and causing the centralized server device to instruct the target universal remote controlling device to upload to the centralized server device the data indicative of the graphical user interface configuration of the target universal remote controlling device in response to the target universal remote controlling device establishing contact with the centralized server device via the network at a time subsequent to the centralized server device receiving the upload request. receiving at a centralized server device from a configuration editing system in communication with the centralized server device via a network an upload request for retrieving the graphical user interface configuration of the target universal remote controlling device , wherein the upload request specifies an address associated with the target universal remote controlling device ; and causing the centralized server device to instruct the target universal remote controlling device to upload to the centralized server device the data indicative of the graphical user interface configuration of the target universal remote controlling device in response to the target universal remote controlling device establishing contact with the centralized server device via the network at a time subsequent to the centralized server device receiving the upload request.
A compound of the formula wherein X 1 is H, a group of formula X 2 and X 3 are independently of each other H, or a group of formula or R 24 is a group of formula R 41 is R 42 is H, or R 21 and R 21' are independently of each other H, a C 1 -C 18 alkoxy group; a C 1 -C 18 alkyl group; or a C 1 -C 18 alkyl group which is interrupted by - O-, or a group of formula R 22 , R 25 , R 26 , R 27 , R 28 , R 25' , R 26' , R 27' , R 28' , R 25" , R 26" , R 27" , R 26" , R 29 , R 29' , R 29" , R 40 , R 43 and R 44 are indepndently of each other H, a C 1 -C 16 alkoxy group; a C 1 -C 18 alkyl group; or a C 1 -C 18 alkyl group which is interrupted by - O-; with the proviso that at least one of X 1 , X 2 and X 3 is a group of formula or comprises a group of formula X 1 is H, a group of formula X 2 and X 3 are independently of each other H, or a group of formula or R 24 is a group of formula R 41 is R 42 is H, or R 21 and R 21' are independently of each other H, a C 1 -C 18 alkoxy group; a C 1 -C 18 alkyl group; or a C 1 -C 18 alkyl group which is interrupted by - O-, or a group of formula R 22 , R 25 , R 26 , R 27 , R 28 , R 25' , R 26' , R 27' , R 28' , R 25" , R 26" , R 27" , R 26" , R 29 , R 29' , R 29" , R 40 , R 43 and R 44 are indepndently of each other H, a C 1 -C 16 alkoxy group; a C 1 -C 18 alkyl group; or a C 1 -C 18 alkyl group which is interrupted by - O-; with the proviso that at least one of X 1 , X 2 and X 3 is a group of formula or comprises a group of formula
A method for processing an original total stream delivering a modified total stream, said original total stream being sent out by a head-end and addressed to a plurality of broadcasting sites, and comprising at least one physical layer pipe encapsulating a transport stream, said method comprising the following steps: - receiving said original total stream, - for at least one physical layer pipe of the original total stream, called an original pipe: - extracting the transport stream encapsulated in said original pipe, called an original transport stream, - obtaining a modified transport stream obtained by replacing at least one main content carried by said original transport stream by at least one secondary content, - time-shifting said original total stream, - aligning at least one reference packet of said modified transport stream with at least one reference packet of said original total stream obtained after the time-shifting, and - replacing , in the original pipe of said original total stream obtained after the time-shifting, said original transport stream by said modified transport stream obtained after the aligning. - receiving said original total stream, - for at least one physical layer pipe of the original total stream, called an original pipe: - extracting the transport stream encapsulated in said original pipe, called an original transport stream, - obtaining a modified transport stream obtained by replacing at least one main content carried by said original transport stream by at least one secondary content, - time-shifting said original total stream, - aligning at least one reference packet of said modified transport stream with at least one reference packet of said original total stream obtained after the time-shifting, and - replacing , in the original pipe of said original total stream obtained after the time-shifting, said original transport stream by said modified transport stream obtained after the aligning. - extracting the transport stream encapsulated in said original pipe, called an original transport stream, - obtaining a modified transport stream obtained by replacing at least one main content carried by said original transport stream by at least one secondary content, - time-shifting said original total stream, - aligning at least one reference packet of said modified transport stream with at least one reference packet of said original total stream obtained after the time-shifting, and - replacing , in the original pipe of said original total stream obtained after the time-shifting, said original transport stream by said modified transport stream obtained after the aligning.
An aerosol delivery device comprising: at least one housing ; and within the at least one housing , a power source configured to provide an output voltage; an aerosol production component powerable to produce an aerosol from an aerosol precursor composition; a sensor configured to produce measurements of atmospheric air pressure in an air flow path through the at least one housing ; a switch coupled to and between the power source and the aerosol production component ; and processing circuitry coupled to the sensor and the switch , and configured to at least: determine a difference between the measurements of atmospheric air pressure from the sensor , and a reference atmospheric air pressure; and only when the difference is at least a threshold difference, output a signal to cause the switch to switchably connect and disconnect the output voltage to the aerosol production component to power the aerosol production component for an aerosol-production time period, the switch caused to switchably connect and disconnect the output voltage to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target. at least one housing ; and within the at least one housing , a power source configured to provide an output voltage; an aerosol production component powerable to produce an aerosol from an aerosol precursor composition; a sensor configured to produce measurements of atmospheric air pressure in an air flow path through the at least one housing ; a switch coupled to and between the power source and the aerosol production component ; and processing circuitry coupled to the sensor and the switch , and configured to at least: determine a difference between the measurements of atmospheric air pressure from the sensor , and a reference atmospheric air pressure; and only when the difference is at least a threshold difference, output a signal to cause the switch to switchably connect and disconnect the output voltage to the aerosol production component to power the aerosol production component for an aerosol-production time period, the switch caused to switchably connect and disconnect the output voltage to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target. determine a difference between the measurements of atmospheric air pressure from the sensor , and a reference atmospheric air pressure; and only when the difference is at least a threshold difference, output a signal to cause the switch to switchably connect and disconnect the output voltage to the aerosol production component to power the aerosol production component for an aerosol-production time period, the switch caused to switchably connect and disconnect the output voltage to adjust power provided to the aerosol production component to a power target that is variable according to a predetermined relationship between the difference and the power target.
Fan for an aircraft cooling unit, comprising a wheel and a shaft line that drives the wheel about an axis (A), said wheel comprising: - a hub carrying an annular row of blades , and - means for connection to said shaft line, which are housed inside said hub, said connection means comprising a bush comprising an internal bore configured for receiving said shaft , said bush being located approximately in a plane (P, P') transverse to said axis or is traversed by said plane, which passes approximately through said blades , said connection means comprising at least one fusible safety element which extends or is arranged around said axis (A) and which is configured to break and rotationally disengage at least one part of said means of said shaft line when a drive torque of the wheel transmitted by said shaft line exceeds a certain threshold, said at least one fusible element having an elongated shape, its extension axis being parallel to said axis (A). - a hub carrying an annular row of blades , and - means for connection to said shaft line, which are housed inside said hub, said connection means comprising a bush comprising an internal bore configured for receiving said shaft , said bush being located approximately in a plane (P, P') transverse to said axis or is traversed by said plane, which passes approximately through said blades ,
Screw comprising a shank which has a first shank portion , a second shank portion and a weld seam connecting the first shank portion to the second shank portion , wherein the first shank portion consists of a first steel with a first carbon concentration and a first material hardness and the second shank portion consists of a second steel with a second carbon concentration and a second material hardness, wherein the second carbon concentration is higher than the first carbon concentration, and wherein the weld seam has a greater material hardness than the first shank portion , characterized in that the material hardness of the weld seam decreases from an internal core of the weld seam to a surface of the weld seam .
A method comprising: accessing, at a computerized system (1000; 1200), a patient metric of a subject; using the patient metric as an input to a machine learning algorithm executing on the computerized system (1000; 1200), the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets for use by a neuromodulator (210; 312; 413; 520; 600) to deliver neuromodulation using a non-regular electrical waveform (910-1, 910-2, 910-3), wherein the non-regular waveform varies over a time domain including variations in timing, size or shape of the non-regular electrical waveform (910-1, 910-2, 910-3) and the non-regular waveform (910-1, 910-2, 910-3) varies over a space domain including variations in stimulation location and direction; and programming the neuromodulator (210; 312; 413; 520; 600) using the candidate neuromodulation parameter set, wherein the neuromodulator (210; 312; 413; 520; 600) programmed with the candidate neuromodulation parameter set is configured to stimulate the subject using the non-regular electrical waveform (910-1, 910-2, 910-3) that varies over the time domain and the space domain. accessing, at a computerized system (1000; 1200), a patient metric of a subject; using the patient metric as an input to a machine learning algorithm executing on the computerized system (1000; 1200), the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets for use by a neuromodulator (210; 312; 413; 520; 600) to deliver neuromodulation using a non-regular electrical waveform (910-1, 910-2, 910-3), wherein the non-regular waveform varies over a time domain including variations in timing, size or shape of the non-regular electrical waveform (910-1, 910-2, 910-3) and the non-regular waveform (910-1, 910-2, 910-3) varies over a space domain including variations in stimulation location and direction; and programming the neuromodulator (210; 312; 413; 520; 600) using the candidate neuromodulation parameter set, wherein the neuromodulator (210; 312; 413; 520; 600) programmed with the candidate neuromodulation parameter set is configured to stimulate the subject using the non-regular electrical waveform (910-1, 910-2, 910-3) that varies over the time domain and the space domain.
A computer readable medium comprising computer executable instructions , the computer executable instructions comprising: a preprocessor that when executed causes a processor to generate, from an interior of a halftone of a captured image of printed media, a band-pass filtered signal of a stegatone or a difference signal between a stegatone and a stegatone model from the aligned captured image of printed media, wherein the halftone is encoded with payload information to form the stegatone, wherein the payload is configured to index the print signature in the registry; a subdivide area processor that when executed causes a processor to process the halftone via an equi-spaced grid and segment the filtered signal or the difference signal in preparation of further image processing of the captured image of printed media; an area code generator that when executed causes a processor to compute a normalized variance in each area of the segmented output from the subdivide area processor and to recover an ordered list of integer values that constitutes a print signature from an interior of a halftone that is encoded with payload information; and a forensic verification system that when executed causes a processor to compare the recovered print signature to a reference signature stored in a print signature registry and perform a statistical image analysis on the print signature and the reference signature based on the comparison to authenticate the printed media by comparing print signature interior differences to a statistical threshold. a preprocessor that when executed causes a processor to generate, from an interior of a halftone of a captured image of printed media, a band-pass filtered signal of a stegatone or a difference signal between a stegatone and a stegatone model from the aligned captured image of printed media, wherein the halftone is encoded with payload information to form the stegatone, wherein the payload is configured to index the print signature in the registry; a subdivide area processor that when executed causes a processor to process the halftone via an equi-spaced grid and segment the filtered signal or the difference signal in preparation of further image processing of the captured image of printed media; an area code generator that when executed causes a processor to compute a normalized variance in each area of the segmented output from the subdivide area processor and to recover an ordered list of integer values that constitutes a print signature from an interior of a halftone that is encoded with payload information; and a forensic verification system that when executed causes a processor to compare the recovered print signature to a reference signature stored in a print signature registry and perform a statistical image analysis on the print signature and the reference signature based on the comparison to authenticate the printed media by comparing print signature interior differences to a statistical threshold.
A wafer of an optical article , the wafer comprising: a laminate comprising: an inner layer comprising a first matrix material having a lower surface and an upper surface opposite the lower surface ; a first outer layer comprising a second matrix material , the first outer layer is coupled to the lower surface of the inner layer ; and a second outer layer comprising a third matrix material, the second outer layer is coupled to the upper surface of the inner layer where the wafer includes a central portion and an outer edge portion and characterized in that the wafer includes an imprint at the outer edge portion such that a first thickness (D3) of the inner layer at the central portion is greater than a second thickness (D4) of the inner layer at the outer edge portion . a laminate comprising: an inner layer comprising a first matrix material having a lower surface and an upper surface opposite the lower surface ; a first outer layer comprising a second matrix material , the first outer layer is coupled to the lower surface of the inner layer ; and a second outer layer comprising a third matrix material, the second outer layer is coupled to the upper surface of the inner layer an inner layer comprising a first matrix material having a lower surface and an upper surface opposite the lower surface ; a first outer layer comprising a second matrix material , the first outer layer is coupled to the lower surface of the inner layer ; and a second outer layer comprising a third matrix material, the second outer layer is coupled to the upper surface of the inner layer where the wafer includes a central portion and an outer edge portion and characterized in that the wafer includes an imprint at the outer edge portion such that a first thickness (D3) of the inner layer at the central portion is greater than a second thickness (D4) of the inner layer at the outer edge portion .