mhurhangee/patent-ind-claim-en huggingface dataset:
A method of producing a lined pipeline with an integrity monitoring system, comprising: providing a first section of lined pipe with a first sensor cable disposed in a continuous annulus between a first host pipe and a first pipe lining ; providing a second section of lined pipe with a second sensor cable disposed in a continuous annulus between a second host pipe and a second pipe lining ; and joining the first pipe lining to the second pipe lining using an electrofusion fitting configured to enable the first sensor cable to communicate with the second sensor cable ; the method further comprising: connecting the first sensor cable to a first end of a sensor cable disposed on or in the electrofusion fitting , and connecting the second sensor cable to a second end of the sensor cable disposed on or in the electrofusion fitting ; or routing the first sensor cable across or through the electrofusion fitting , whereby the first and second sensor cables are provided by a single continuous sensor cable . providing a first section of lined pipe with a first sensor cable disposed in a continuous annulus between a first host pipe and a first pipe lining ; providing a second section of lined pipe with a second sensor cable disposed in a continuous annulus between a second host pipe and a second pipe lining ; and joining the first pipe lining to the second pipe lining using an electrofusion fitting configured to enable the first sensor cable to communicate with the second sensor cable ; the method further comprising: connecting the first sensor cable to a first end of a sensor cable disposed on or in the electrofusion fitting , and connecting the second sensor cable to a second end of the sensor cable disposed on or in the electrofusion fitting ; or routing the first sensor cable across or through the electrofusion fitting , whereby the first and second sensor cables are provided by a single continuous sensor cable . connecting the first sensor cable to a first end of a sensor cable disposed on or in the electrofusion fitting , and connecting the second sensor cable to a second end of the sensor cable disposed on or in the electrofusion fitting ; or routing the first sensor cable across or through the electrofusion fitting , whereby the first and second sensor cables are provided by a single continuous sensor cable .
A composition comprising a biguanide compound for use in treating a disorder of glucose metabolism, wherein the biguanide compound is selected from a compound of structural Formula I, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are independently selected from: H, OH, O-Rx, wherein Rx is alkyl, cycloalkyl, alkylcycloalkyl, acyl, ester, or thioester; optionally substituted alkyl; cycloalkyl; alkylcycloalkyl; heterocycloalkyl; alkylheterocycloalkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted aryl; optionally substituted alkylaryl; optionally substituted heteroaryl; and optionally substituted alkylheteroaryl; or R 1 and R 2 together form a 3 to 8 membered heterocyclic ring, including the nitrogen atom to which they are attached; or R 4 and R 5 together form a ring selected from: aziridine, pyrrolyl, imidazolyl, pyrazolyl, indolyl, indolinyl, pyrrolidinyl, piperazinyl and piperidyl, including the nitrogen atom to which they are attached; wherein the composition is adapted to reduce the average systemic bioavailability of the biguanide compound to 70%, 60%, 50%, 40%, 30% or 20% less relative bioavailability compared to an immediate release composition having the same amount of the compound, and to release a therapeutically effective amount of the compound to one or more regions of the intestine of a subject. H, OH, O-Rx, wherein Rx is alkyl, cycloalkyl, alkylcycloalkyl, acyl, ester, or thioester; optionally substituted alkyl; cycloalkyl; alkylcycloalkyl; heterocycloalkyl; alkylheterocycloalkyl; optionally substituted alkenyl; optionally substituted alkynyl; optionally substituted aryl; optionally substituted alkylaryl; optionally substituted heteroaryl; and optionally substituted alkylheteroaryl; or R 1 and R 2 together form a 3 to 8 membered heterocyclic ring, including the nitrogen atom to which they are attached; or R 4 and R 5 together form a ring selected from: aziridine, pyrrolyl, imidazolyl, pyrazolyl, indolyl, indolinyl, pyrrolidinyl, piperazinyl and piperidyl, including the nitrogen atom to which they are attached; wherein the composition is adapted to reduce the average systemic bioavailability of the biguanide compound to 70%, 60%, 50%, 40%, 30% or 20% less relative bioavailability compared to an immediate release composition having the same amount of the compound, and to release a therapeutically effective amount of the compound to one or more regions of the intestine of a subject.
A pharmaceutical composition comprising an anti-HER2xPRLR bispecific antibody and a cytotoxic agent, wherein the cytotoxic agent is an antibody drug conjugate (ADC) comprising a drug, toxin or radioisotope conjugated to an antibody that specifically binds the HER2, wherein the antigen-binding portion of the ADC binds an epitope on HER2 that does not overlap with the epitope on HER2 recognized by the anti-HER2xPRLR bispecific antibody.
A locking unit for a rotor lock system of a wind turbine , the locking unit comprising: a locking shaft that is slidably movable within a barrel under the influence of an actuator ; and an angular drive arrangement which is configured to enable angular movement of the locking shaft about a longitudinal axis as the locking shaft is moved linearly within the barrel by the actuator , characterized in that the angular drive arrangement comprises a helical guide formation defined by the barrel and a complementary rider formation defined by the locking shaft . a locking shaft that is slidably movable within a barrel under the influence of an actuator ; and an angular drive arrangement which is configured to enable angular movement of the locking shaft about a longitudinal axis as the locking shaft is moved linearly within the barrel by the actuator , characterized in that the angular drive arrangement comprises a helical guide formation defined by the barrel and a complementary rider formation defined by the locking shaft .
A method for manufacturing bent-neck bottles, which are manufactured from a plastic material, for example PET (polyethene terephthalate), and comprising a prior injection moulding phase in which a preform is created, consisting of a cylindrical body with an open end with the already defined neck and another closed end, and a subsequent phase in which the preform is located inside a mould where it is stretched via the insertion of a rod and the pre-blowing and/or blowing thereof by blowing pressurised air through the mouth of the preform , characterised in that, after the preform creation phase and before the insertion thereof into the mould , a phase is included in which said preform is subjected without stretching to a folding process in which an angular offset is carried out between the axis of the neck of the preform and the longitudinal axis of the body thereof.
A stable colloidal dispersion comprising: (a) a non-conductive, non-aqueous and non-water miscible fluid, (b) at least one solid nanoparticle, wherein the solid comprises at least one of a metal oxide, metal carbide, and mixtures thereof, and (c) a surfactant. (a) a non-conductive, non-aqueous and non-water miscible fluid, (b) at least one solid nanoparticle, wherein the solid comprises at least one of a metal oxide, metal carbide, and mixtures thereof, and (c) a surfactant.
Operating method for a motor starter that is connected to a multiphase power supply comprising an electromechanical switch and a parallel semiconductor switch in at least one current-carrying phase with the following steps: a) provision of the motor starter in an operating state in which the electromechanical switch is closed and the semiconductor switch is open; b) subsequently closing the semiconductor switch ; c) opening the electromechanical switch by detaching a first and a second end of a switching piece from an assigned stationary contact ; wherein, in order to reduce a current gradient in the semiconductor switch , the opening in the step c) includes a tilting movement of the switching piece , wherein the current gradient should be understood as a change to the present current intensity based on the time, and wherein, in step c), an actuation period passes between the detachment of the first and second end of the switching piece . a) provision of the motor starter in an operating state in which the electromechanical switch is closed and the semiconductor switch is open; b) subsequently closing the semiconductor switch ; c) opening the electromechanical switch by detaching a first and a second end of a switching piece from an assigned stationary contact ;
An x-ray device designed to be handheld and configured for radiographic imaging, comprising: a housing containing an x-ray tube , wherein the x-ray tube is insulated with a low-density insulating material and shield to absorb stray x-rays with a high-Z substance; wherein the high-Z substance is dispersed in the low-density insulating material; an integrated power system providing a continuous high voltage DC power and a constant x-ray radiation output with a high current load suitable for medical, dental, radiographic imaging, the power system comprising: a power source comprising a battery, and a power supply , which is provided by a plurality of individual power supplies enclosed within the housing ; and a shield configured to shield the operator of the device from backscatter radiation from an object being analyzed. a housing containing an x-ray tube , wherein the x-ray tube is insulated with a low-density insulating material and shield to absorb stray x-rays with a high-Z substance; wherein the high-Z substance is dispersed in the low-density insulating material; an integrated power system providing a continuous high voltage DC power and a constant x-ray radiation output with a high current load suitable for medical, dental, radiographic imaging, the power system comprising: a power source comprising a battery, and a power supply , which is provided by a plurality of individual power supplies enclosed within the housing ; and a shield configured to shield the operator of the device from backscatter radiation from an object being analyzed. a power source comprising a battery, and a power supply , which is provided by a plurality of individual power supplies enclosed within the housing ; and a shield configured to shield the operator of the device from backscatter radiation from an object being analyzed.
A flux composition for laser welding, comprising: 5 to 85 percent by weight of a metal oxide, a metal silicate, or both; 10 to 70 percent by weight of a metal fluoride; and 1 to 30 percent by weight of a metal carbonate, relative to a total weight of the composition, wherein: the flux composition contains less than 0.5 percent by weight of iron; and the flux composition contains less than 0.5 percent by weight of Li 2 O, Na 2 O or K 2 O, wherein the flux composition comprises 5 percent or less by weight of at least one selected from the group consisting of titanium, a titanium alloy, titanium oxide, titanite, aluminum, an aluminum alloy, aluminum carbonate, dawsonite, a nickel titanium alloy, zirconium and a zirconium alloy, relative to a total weight of the composition, wherein the flux composition comprises at least two metal carbonates, wherein the flux composition comprises greater than 7.5 percent by weight of zirconia, relative to a total weight of the composition, wherein the flux composition further comprises a metal carbide. 5 to 85 percent by weight of a metal oxide, a metal silicate, or both; 10 to 70 percent by weight of a metal fluoride; and 1 to 30 percent by weight of a metal carbonate, the flux composition contains less than 0.5 percent by weight of iron; and the flux composition contains less than 0.5 percent by weight of Li 2 O, Na 2 O or K 2 O, wherein the flux composition comprises 5 percent or less by weight of at least one selected from the group consisting of titanium, a titanium alloy, titanium oxide, titanite, aluminum, an aluminum alloy, aluminum carbonate, dawsonite, a nickel titanium alloy, zirconium and a zirconium alloy, relative to a total weight of the composition, wherein the flux composition comprises at least two metal carbonates, wherein the flux composition comprises greater than 7.5 percent by weight of zirconia, relative to a total weight of the composition, wherein the flux composition further comprises a metal carbide.
A method of screening biochemical entities, the method comprising: (a) providing a library comprising 6 or more candidate biochemical entities; (b) measuring a first conformational state of an intrinsically disordered protein, thereby generating a baseline; (c) contacting each of the candidate biochemical entities with the same intrinsically disordered protein; (d) measuring a second conformational state of the intrinsically disordered protein; (e) determining a signature for at least a first and a second candidate biochemical entity using the second conformational state (f) comparing the signature of the first candidate biochemical entity to the signature of the second candidate biochemical entity; and (g) selecting, based on the comparison in (f), one or more biochemical entities from the candidate biochemical entities, wherein the candidate biochemical entities are small molecules that share a common scaffold core, and wherein the measuring steps comprise measurements of second harmonic generation (SHG). (a) providing a library comprising 6 or more candidate biochemical entities; (b) measuring a first conformational state of an intrinsically disordered protein, thereby generating a baseline; (c) contacting each of the candidate biochemical entities with the same intrinsically disordered protein; (d) measuring a second conformational state of the intrinsically disordered protein; (e) determining a signature for at least a first and a second candidate biochemical entity using the second conformational state (f) comparing the signature of the first candidate biochemical entity to the signature of the second candidate biochemical entity; and (g) selecting, based on the comparison in (f), one or more biochemical entities from the candidate biochemical entities,
A method of performing a paging reception, adapted to a user equipment , UE, wherein the method comprising: receiving a paging message, wherein the paging message comprises a first list; determining whether a UE identity of the UE is included in the first list; determining whether a paging cause corresponding to the UE identity is indicated by a second list of the paging message after determining that the UE identity is included in the first list; forwarding, by a radio resource control, RRC, layer of the UE, the paging cause to an upper layer of the UE in response to the paging cause being indicated by the second list; and performing, by the upper layer, a communication operation according to the paging cause. receiving a paging message, wherein the paging message comprises a first list; determining whether a UE identity of the UE is included in the first list; determining whether a paging cause corresponding to the UE identity is indicated by a second list of the paging message after determining that the UE identity is included in the first list; forwarding, by a radio resource control, RRC, layer of the UE, the paging cause to an upper layer of the UE in response to the paging cause being indicated by the second list; and performing, by the upper layer, a communication operation according to the paging cause.
A motor assembly , comprising: a power plane (P) configured with a circular geometry to be mounted inside a space envelope having a substantially similar circular geometry formed on an end-plate (D') between an inner hub portion and a peripheral portion that extends circumferentially around the space envelope of the end-plate, the power plane configured as a multi-layer circuit board or assembly having at least: a power layer with at least one power module (PM, PM1 - PM7) for providing power to a motor (M), a control layer with at least one control electronics module for controlling the power provided to the motor (M), and printed circuit board layer between the power layer and the control layer that provides electrical connection paths between the at least one power module of the power plane and the at least one control electronics module of the control layer, and also that provides insulation between the power layer and the control layer, wherein the at least one power module comprises matrix converter power modules configured as part of a matrix converter to receive AC input signaling having an AC waveform with a voltage and frequency and provide converted AC signaling having a converted AC waveform with a converted voltage and frequency to drive the motor (M), characterized by a thermal barrier between the power layer and the control layer, wherein the power plane is configured as a doughnut shaped power plane printed circuit board (P ) or assembly in order to fit in the space envelope of the end-plate for providing a maximum space for mounting the power layer and the control layer, and to allow a shaft of the motor rotor (R) to pass through to drive a cooling fan (F); and wherein the power layer comprises a circular power modules arrangement (P/ CM) configured on one side of the thermal barrier and printed circuit board layer to couple to the power plane (P) low inductance input and integrated output connections attached to an intermediate portion of the end-plate.
A system for purifying a supply stream containing lactose, the system comprising: a clarification system configured to remove insoluble impurities from the supply stream to produce a clarified stream; and an adsorption system fluidically coupled to the clarification system, wherein the adsorption system comprises an adsorbent resin selected to bind riboflavin to decolorize the clarified stream, wherein the adsorbent resin comprises a riboflavin binding macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups. a clarification system configured to remove insoluble impurities from the supply stream to produce a clarified stream; and an adsorption system fluidically coupled to the clarification system, wherein the adsorption system comprises an adsorbent resin selected to bind riboflavin to decolorize the clarified stream, wherein the adsorbent resin comprises a riboflavin binding macroporous copolymer resin comprising: a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups. a monovinyl aromatic monomer selected from styrene and styrene derivatives chosen from α-methylstyrene, vinyl toluene, vinyl naphthalene, vinylbenzyl chloride, and vinylbenzyl alcohol, and a crosslinking monomer, where the macroporous copolymer has been post-crosslinked in a swollen state in the presence of a Friedel-Crafts catalyst and functionalized with hydrophilic groups.
An exchange method, applicable by an exchange apparatus, said method comprising the steps of: receiving M bytes and M bits corresponding to the M bytes, through a first interface of the exchange apparatus, wherein each of the M bits is used to indicate a status of a corresponding byte; encapsulating L bytes of the M bytes based on the M bits corresponding to the M bytes, to obtain L encapsulated bytes, wherein M and L are integers greater than or equal to 1, and L is less than M; transmitting the L encapsulated bytes to a second interface of the exchange apparatus; decapsulating the L encapsulated bytes to obtain L decapsulated bytes; and sending the L decapsulated bytes through the second interface of the exchange apparatus. receiving M bytes and M bits corresponding to the M bytes, through a first interface of the exchange apparatus, wherein each of the M bits is used to indicate a status of a corresponding byte; encapsulating L bytes of the M bytes based on the M bits corresponding to the M bytes, to obtain L encapsulated bytes, wherein M and L are integers greater than or equal to 1, and L is less than M; transmitting the L encapsulated bytes to a second interface of the exchange apparatus; decapsulating the L encapsulated bytes to obtain L decapsulated bytes; and sending the L decapsulated bytes through the second interface of the exchange apparatus.
A method for estimating a direct-to-reverberant ratio of a sound signal , wherein the direct-to-reverberant ratio is indicative of a ratio between direct sound received from a sound source and reverberated sound received from reflections in an environment of the sound source, the method comprising: determining a first energy value of a sound signal for a first time frame; assigning to an onset value of the first time frame a positive value, if the difference of the first energy value of the first time frame and a second energy value of a preceding second time frame is greater than a threshold, and a zero value otherwise; determining the direct-to-reverberant ratio by providing an onset signal comprising the onset value to a machine learning algorithm , which has been trained to determine the direct-to-reverberant ratio based on said onset signal. determining a first energy value of a sound signal for a first time frame; assigning to an onset value of the first time frame a positive value, if the difference of the first energy value of the first time frame and a second energy value of a preceding second time frame is greater than a threshold, and a zero value otherwise; determining the direct-to-reverberant ratio by providing an onset signal comprising the onset value to a machine learning algorithm , which has been trained to determine the direct-to-reverberant ratio based on said onset signal.