mhurhangee/patent-ind-claim-en huggingface dataset:
A stable liquid pharmaceutical formulation comprising: (a) an antibody which binds specifically to human programmed death-1 (PD-1),wherein the antibody comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained in a heavy chain variable region (HCVR) and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained in a light chain variable region (LCVR), wherein HCDR1 comprises SEQ ID NO: 3, HCDR2 comprises SEQ ID NO: 4, HCDR3 comprises SEQ ID NO: 5, LCDR1 comprises SEQ ID NO: 6, LCDR2 comprises SEQ ID NO: 7, and LCDR3 comprises SEQ ID NO: 8; (b) a buffer comprising histidine; (c) an organic solvent comprising polysorbate; (d) sucrose as stabilizer; and (e) proline as viscosity modifier; wherein the stable liquid pharmaceutical formulation has a pH of 6.0 ± 0.3. (a) an antibody which binds specifically to human programmed death-1 (PD-1),wherein the antibody comprises three heavy chain complementarity determining regions (CDRs) (HCDR1, HCDR2 and HCDR3) contained in a heavy chain variable region (HCVR) and three light chain CDRs (LCDR1, LCDR2 and LCDR3) contained in a light chain variable region (LCVR), wherein HCDR1 comprises SEQ ID NO: 3, HCDR2 comprises SEQ ID NO: 4, HCDR3 comprises SEQ ID NO: 5, LCDR1 comprises SEQ ID NO: 6, LCDR2 comprises SEQ ID NO: 7, and LCDR3 comprises SEQ ID NO: 8; (b) a buffer comprising histidine; (c) an organic solvent comprising polysorbate; (d) sucrose as stabilizer; and (e) proline as viscosity modifier;
An operating method for a portable electric device, the portable electric device having a fixing component , a body , and an authentication register disposed in the body , the body having a first part and a second part, the method comprising the following steps in order: determining whether the fixing component is attached to the body so that the first part and the second part of the body are attached to each other to make the body a ring shape; and performing a first biometric identity, ID, verification when the fixing component is attached to the body ; characterised in both setting the authentication register and locking the fixing component attached to the body when the first biometric ID verification is successful, and performing a security related application when the authentication register is set and the fixing component is locked to the body; and when the first biometric ID verification is successful, the authentication register is set to a first value and the fixing component is locked to the body , the method further comprises: setting the authentication register to a second value when the fixing component is detached from the body without a second biometric ID verification; wherein the security related application is performed only when the authentication register is set to the first value. determining whether the fixing component is attached to the body so that the first part and the second part of the body are attached to each other to make the body a ring shape; and performing a first biometric identity, ID, verification when the fixing component is attached to the body ; characterised in both setting the authentication register and locking the fixing component attached to the body when the first biometric ID verification is successful, and performing a security related application when the authentication register is set and the fixing component is locked to the body; and when the first biometric ID verification is successful, the authentication register is set to a first value and the fixing component is locked to the body , the method further comprises: setting the authentication register to a second value when the fixing component is detached from the body without a second biometric ID verification; wherein the security related application is performed only when the authentication register is set to the first value. setting the authentication register to a second value when the fixing component is detached from the body without a second biometric ID verification; wherein the security related application is performed only when the authentication register is set to the first value.
A computer-implemented allelotyping method comprising: selecting , from among a group of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing (MPS) instrument, a plurality of text strings for which the nucleotide sequences represented by the selected plurality of text strings each correspond to a particular locus; comparing the selected plurality of text strings to one another to determine an abundance count for each unique text string included in the selected plurality of text strings; and determining one or more alleles for the particular locus by comparing the abundance count for each unique text string included in the selected plurality of text strings to an abundance threshold. selecting , from among a group of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing (MPS) instrument, a plurality of text strings for which the nucleotide sequences represented by the selected plurality of text strings each correspond to a particular locus; comparing the selected plurality of text strings to one another to determine an abundance count for each unique text string included in the selected plurality of text strings; and determining one or more alleles for the particular locus by comparing the abundance count for each unique text string included in the selected plurality of text strings to an abundance threshold.
An adapter device , for use with an exercise bench (P) for weight lifting, the exercise bench having a bench surface (S) configured to support part of a body of an athlete in a lying position, defining a longitudinal direction (L) corresponding to an athlete's height and a transverse direction (T) corresponding to a width of the athlete's body, wherein the adapter device comprises: - a first and a second lateral arm, each one spaced transversely from each other and arranged externally side by side to a respective longitudinal edge of the exercise bench; - a main platform , wherein said first and second lateral arm and said main platform define a supporting surface for the athlete's body which is substantially "U" or "C" shaped; - elevation means of said supporting surface , configured to support said first and second lateral arm and said main platform in an elevated position with respect to a walking plane and substantially placed side by side to the bench surface, wherein said supporting surface is configured to receive as rest a lateral part of the athlete's torso at said first and second lateral arm and the lower limbs of the latter, in particular for their whole length, at said main platform , and wherein said supporting surface is substantially continuous. - a first and a second lateral arm, each one spaced transversely from each other and arranged externally side by side to a respective longitudinal edge of the exercise bench; - a main platform , wherein said first and second lateral arm and said main platform define a supporting surface for the athlete's body which is substantially "U" or "C" shaped; - elevation means of said supporting surface , configured to support said first and second lateral arm and said main platform in an elevated position with respect to a walking plane and substantially placed side by side to the bench surface, wherein said supporting surface is configured to receive as rest a lateral part of the athlete's torso at said first and second lateral arm and the lower limbs of the latter, in particular for their whole length, at said main platform , and wherein said supporting surface is substantially continuous.
A method for processing computer network requests, the method comprising: receiving from a requesting computer an encoded value in a domain name resolution request, wherein the encoded value has a valid domain name syntax; decoding the encoded value into a Uniform Resource Locator having a host portion and a non-host portion; identifying routing criteria matching a combination of the host portion of the Uniform Resource Locator and the non-host portion of the Uniform Resource Locator, wherein the routing criteria are associated with a computer network address of a proxy server, and wherein the computer network address is associated with a security policy to apply to communications directed to the proxy server; and sending the computer network address of the proxy server to the requesting computer in response to the domain name resolution request to route packets directed to the Uniform Resource Locator to the proxy server and apply the associated security policy to the routed packets. receiving from a requesting computer an encoded value in a domain name resolution request, wherein the encoded value has a valid domain name syntax; decoding the encoded value into a Uniform Resource Locator having a host portion and a non-host portion; identifying routing criteria matching a combination of the host portion of the Uniform Resource Locator and the non-host portion of the Uniform Resource Locator, wherein the routing criteria are associated with a computer network address of a proxy server, and wherein the computer network address is associated with a security policy to apply to communications directed to the proxy server; and sending the computer network address of the proxy server to the requesting computer in response to the domain name resolution request to route packets directed to the Uniform Resource Locator to the proxy server and apply the associated security policy to the routed packets.
An external retention device for securing a catheter exiting a stoma , comprising: a base plate for engagement with the abdomen of a patient; a guiding part comprising a concave channel open to the top side thereof, for guiding the catheter from the base plate through a first curved section of the concave channel to a substantially parallel position relative to the base plate in a second section of the concave channel ; a fixation part having an open state and a closed state for encircling and fixing the catheter within the second section of the guiding part , the fixation part comprising a clip closure comprising two interlocking elements and a hinge therebetween, wherein at least one of the interlocking elements comprises rigid polymeric material and at least the base plate comprise an elastomeric polymer, characterized in that the hinge also comprises an elastomeric polymer, the base plate , guiding part and fixation part are integrally formed as a single device, and the rigid polymeric material is at least in part overmolded by the elastomeric polymer. a base plate for engagement with the abdomen of a patient; a guiding part comprising a concave channel open to the top side thereof, for guiding the catheter from the base plate through a first curved section of the concave channel to a substantially parallel position relative to the base plate in a second section of the concave channel ; a fixation part having an open state and a closed state for encircling and fixing the catheter within the second section of the guiding part , the fixation part comprising a clip closure comprising two interlocking elements and a hinge therebetween, wherein at least one of the interlocking elements comprises rigid polymeric material and at least the base plate comprise an elastomeric polymer, characterized in that the hinge also comprises an elastomeric polymer, the base plate , guiding part and fixation part are integrally formed as a single device, and the rigid polymeric material is at least in part overmolded by the elastomeric polymer.
An insulation product containing fiber-based insulation, wherein at least a portion of the fiber-based insulation is confined in a gastight space which contains at least one gas whose thermal conductivity is lower than that of air, wherein the pressure existing in the gastight space substantially corresponds to normal atmospheric pressure (about 1 atm), wherein said at least one gas is selected from among carbon dioxide (CO 2 ), argon (Ar) and xenon (Xe), and wherein the insulation product is a sheet metal - coated mineral wool element, wherein between two large co-directional sheet metals are provided mineral wool lamellae with mineral wool fibers in a lengthwise orientation thereof being substantially perpendicular to said two large co-directional sheet metals, and that the gastight space is established between said two large co-directional sheet metals and the inside of two outermost lamellae in such a way that on the inside of at least the two outermost lamellae is provided a gastight vertical membrane or sheet metal which is fastened in a gastight manner to said two large co-directional sheet metals .
A cooling device for an under-floor device for a vehicle, wherein the cooling device is configured to be arranged under a floor of the vehicle and is configured to cool down the under-floor device arranged under the floor of the vehicle by using a traveling wind , as a cooling wind, generated as the vehicle travels, the cooling device comprising: a base plate to a rear surface side of which the under-floor device is attachable; a heat radiating unit attached to a front surface side of the base plate and configured to radiate heat conducted from the under-floor device via the base plate ; a cover that surrounds the heat radiating unit and includes a first side opening provided in a first side surface of the cover and capable of causing the traveling wind to flow therein, and a second side opening provided in a second side surface that is opposite to the first side surface of the cover with respect to the travelling direction of the vehicle and capable of causing the traveling wind to flow out from the cover , wherein the first and second side surfaces of the cover are configured to face a traveling direction of the vehicle; and characterized in that the cooling device includes a guide plate configured to guide the traveling wind flowing in from the first side opening to the heat radiating unit by blocking at least part of a gap area between a surface connecting the first and second side surfaces of the cover and the heat radiating unit , and the guide plate is provided in a side gap area between the first side surface of the cover and the heat radiating unit . a base plate to a rear surface side of which the under-floor device is attachable; a heat radiating unit attached to a front surface side of the base plate and configured to radiate heat conducted from the under-floor device via the base plate ; a cover that surrounds the heat radiating unit and includes a first side opening provided in a first side surface of the cover and capable of causing the traveling wind to flow therein, and a second side opening provided in a second side surface that is opposite to the first side surface of the cover with respect to the travelling direction of the vehicle and capable of causing the traveling wind to flow out from the cover , wherein the first and second side surfaces of the cover are configured to face a traveling direction of the vehicle; and characterized in that the cooling device includes a guide plate configured to guide the traveling wind flowing in from the first side opening to the heat radiating unit by blocking at least part of a gap area between a surface connecting the first and second side surfaces of the cover and the heat radiating unit , and the guide plate is provided in a side gap area between the first side surface of the cover and the heat radiating unit .
Grinder-doser apparatus of the type with weight control, intended to grind and precisely dose coffee in beans dispensing the ground product in a filter-holding bowl for espresso coffee, which integrates a weighing device with a load cell for the real-time weighing of the dose during dispensing and for automatically controlling the actually dispensed dose weight in grams, with the motor off, with consequent automatic calibration; said grinder-doser apparatus consisting of an upper part and of a lower part acting as a base , wherein between them a load cell is interposed, which progressively detects the weight loss of said upper part ; said upper part comprising: a machine body with the conventional grinding means like the grinders and the motor , a front dispensing compartment which is crossed by a chute duct the front end of which is the dispensing spout , a screen acting as a control panel, a cone-shaped container for the roasted coffee beans, which is placed above said machine body ; said grinder-doser apparatus , of the electromechanical type with electronic control, being equipped with a logic control unit , which is connected, at least for data transfer, to said screen , to said motor and to said cell ; and wherein said upper part has a barycentric arrangement configuration on the detection plane of the cell , that is to say, with the vertical axis passing through the cone , the grinders and the motor , which is of the barycentric type; said load cell and said logic unit being intended to dispense the desired dose by stopping the motor before reaching the required weight (PR), that is to say, taking into account an amount of ground coffee that is dispensed anyway after the motor has been switched off, which is conventionally called residual amount (QV); said grinder-doser apparatus being characterised in that the hooking of the filter-holding bowl is independent of the weighing since it is constrained to said base , below the cell , said base being shaped in such a way as to integrate the supporting and centering fork making it independent of said upper part .
A positive airway pressure device comprising: a flow generator configured to provide gas at a pressure to a patient; a sensor configured to measure breathing of the patient; and a control system configured to: detect sleep disordered breathing based at least in part on analysis of data acquired by the sensor ; determine a sleep state of the patient based at least in part on analysis of data acquired by the sensor ; control the flow generator to provide a pressure between a low pressure, which is greater than or equal to about 4 cmH 2 O, and a high pressure, which is less than or equal to about 20 cmH 2 O, when the sleep state is determined to be asleep, the pressure provided based at least in part on whether sleep disordered breathing is detected; and control the flow generator to provide an awake pressure lower than the low pressure if the sleep state is determined to be awake, wherein the awake pressure is selectable by a user and is a therapeutic pressure greater than or equal to about 4 cmH 2 O. a flow generator configured to provide gas at a pressure to a patient; a sensor configured to measure breathing of the patient; and a control system configured to: detect sleep disordered breathing based at least in part on analysis of data acquired by the sensor ; determine a sleep state of the patient based at least in part on analysis of data acquired by the sensor ; control the flow generator to provide a pressure between a low pressure, which is greater than or equal to about 4 cmH 2 O, and a high pressure, which is less than or equal to about 20 cmH 2 O, when the sleep state is determined to be asleep, the pressure provided based at least in part on whether sleep disordered breathing is detected; and control the flow generator to provide an awake pressure lower than the low pressure if the sleep state is determined to be awake, wherein the awake pressure is selectable by a user and is a therapeutic pressure greater than or equal to about 4 cmH 2 O. detect sleep disordered breathing based at least in part on analysis of data acquired by the sensor ; determine a sleep state of the patient based at least in part on analysis of data acquired by the sensor ; control the flow generator to provide a pressure between a low pressure, which is greater than or equal to about 4 cmH 2 O, and a high pressure, which is less than or equal to about 20 cmH 2 O, when the sleep state is determined to be asleep, the pressure provided based at least in part on whether sleep disordered breathing is detected; and control the flow generator to provide an awake pressure lower than the low pressure if the sleep state is determined to be awake, wherein the awake pressure is selectable by a user and is a therapeutic pressure greater than or equal to about 4 cmH 2 O.
A concrete structure , comprising: a repair cross section which is formed at a deteriorated or damaged part in the concrete structure ; a reinforcing grid in which a plurality of reinforcing spacers and a plurality of reinforcing channels , at certain intervals, are arranged in a grid shape; a reinforcing panel precast-fabricated in a fabricating place with the reinforcing grid embedded therein; a set anchor which comprises an anchor bolt and an anchor nut and fixes the reinforcing panel to the repair cross section of the concrete structure ; and repairing cement mortar injected between the repair cross section of the concrete structure and the reinforcing panel , the concrete structure being characterized in that the reinforcing channels form a plurality of openings and that the repairing cement mortar is injected into the openings formed by the reinforcing channels to integrate the concrete structure with the reinforcing panel . a repair cross section which is formed at a deteriorated or damaged part in the concrete structure ; a reinforcing grid in which a plurality of reinforcing spacers and a plurality of reinforcing channels , at certain intervals, are arranged in a grid shape; a reinforcing panel precast-fabricated in a fabricating place with the reinforcing grid embedded therein; a set anchor which comprises an anchor bolt and an anchor nut and fixes the reinforcing panel to the repair cross section of the concrete structure ; and repairing cement mortar injected between the repair cross section of the concrete structure and the reinforcing panel , the concrete structure being characterized in that the reinforcing channels form a plurality of openings and that the repairing cement mortar is injected into the openings formed by the reinforcing channels to integrate the concrete structure with the reinforcing panel .
A composite thermal insulation sheet comprising: an aerogel sheet; a sol-impermeable coating layer formed on one surface of the aerogel sheet; and one or more functional layers formed on the other surface of the aerogel sheet; wherein the thickness of the sol-impermeable coating layer is 30 μm or less; wherein the thickness of the composite thermal insulation sheet is 3 mm or less. an aerogel sheet; a sol-impermeable coating layer formed on one surface of the aerogel sheet; and one or more functional layers formed on the other surface of the aerogel sheet; wherein the thickness of the sol-impermeable coating layer is 30 μm or less; wherein the thickness of the composite thermal insulation sheet is 3 mm or less.
A fermentation enclosure in the form of a flexible pouch having first and second openings therein, the first opening having a removable cap assembly and the second opening having a liquid dispensing arrangement for selective dispensing of liquid from the interior of the pouch , wherein the pouch comprises first and second opposing flexible sheets sealed together at opposing edges to define an internal cavity there-between and an intermediate sheet interposed between the first and second sheets to provide a base of the pouch in use such that the pouch is arranged to provide a self-supporting enclosure when at least partially filled with liquid, and the removable cap assembly is arranged to vent pressure from the interior of the pouch over a predetermined pressure range, wherein at least one sealed edge is arranged to yield at a predetermined internal pressure within the pouch of between 0.28 and 0.83 bar relative to the ambient external pressure.