mhurhangee/patent-ind-claim-en huggingface dataset:
A method of determining the likelihood that a subject has lung cancer, the method comprising (a) subjecting mRNA of a biological sample of the subject to a gene expression analysis, wherein the gene expression analysis comprises (i) determining mRNA expression levels in the biological sample of one or more informative genes that relate to lung cancer status, and (ii) determining mRNA expression levels in the biological sample of one or more genomic correlate genes that relate to one or more self-reportable characteristics of the subject, wherein said one or more genomic correlate genes are different from said informative genes; and (b) generating a lung cancer risk assessment using a lung-cancer classifier, based on the expression levels determined in (i) and (ii), wherein the lung cancer risk assessment is indicative of the likelihood that the subject has lung cancer, wherein the genomic correlate genes comprise (i) SLC7A11, CLND10 or TKT when the one or more self-reportable characteristics of the subject include smoking, or (ii) AKR1C2 or RUNX1T1 when the one or more self-reportable characteristics of the subject include smoking history, or (iii) CD52, SYT8, TNNT3, ALXI, KLRKI, RASA3, CERS3, ASPA, GRP, APOCI, EPHX3, REEPI, FAM198B, PCDHB4, PCDHB16, FOXD1, SPARC, NKAPL, or GPR110 when the one or more self-reportable characteristics of the subject include age. (a) subjecting mRNA of a biological sample of the subject to a gene expression analysis, wherein the gene expression analysis comprises (i) determining mRNA expression levels in the biological sample of one or more informative genes that relate to lung cancer status, and (ii) determining mRNA expression levels in the biological sample of one or more genomic correlate genes that relate to one or more self-reportable characteristics of the subject, wherein said one or more genomic correlate genes are different from said informative genes; and (i) determining mRNA expression levels in the biological sample of one or more informative genes that relate to lung cancer status, and (ii) determining mRNA expression levels in the biological sample of one or more genomic correlate genes that relate to one or more self-reportable characteristics of the subject, wherein said one or more genomic correlate genes are different from said informative genes; and (b) generating a lung cancer risk assessment using a lung-cancer classifier, based on the expression levels determined in (i) and (ii), wherein the lung cancer risk assessment is indicative of the likelihood that the subject has lung cancer, (i) SLC7A11, CLND10 or TKT when the one or more self-reportable characteristics of the subject include smoking, or (ii) AKR1C2 or RUNX1T1 when the one or more self-reportable characteristics of the subject include smoking history, or (iii) CD52, SYT8, TNNT3, ALXI, KLRKI, RASA3, CERS3, ASPA, GRP, APOCI, EPHX3, REEPI, FAM198B, PCDHB4, PCDHB16, FOXD1, SPARC, NKAPL, or GPR110 when the one or more self-reportable characteristics of the subject include age.
A cryogenic liquid dispensing system comprising; a. a tank defining an area that holds cryogenic liquid ; b. a pump ; c. a first supply line in liquid communication with the bottom portion of the tank and the pump ; d. a first supply valve located in the first supply line between the bottom portion of the tank and the pump ; e. a recycle line ; f. a recycle valve ; g. a dispensing line in liquid communication with the recycle line at a location between the pump and the recycle valve ; h. a dispensing valve in the dispensing line ; characterised in that ; i. the system comprises a basin defining an area configured to hold cryogenic liquid at a height raised above a bottom portion of the tank , and being in liquid communication with the tank ; j. the recycle line is in liquid communication with the pump and the basin ; k. the recycle valve is located in the recycle line between the pump and the basin ; l. a second supply line in liquid communication with a bottom portion of the basin and the pump ; and m. a second supply valve located in the second supply line between the bottom portion of the basin and the pump . a. a tank defining an area that holds cryogenic liquid ; b. a pump ; c. a first supply line in liquid communication with the bottom portion of the tank and the pump ; d. a first supply valve located in the first supply line between the bottom portion of the tank and the pump ; e. a recycle line ; f. a recycle valve ; g. a dispensing line in liquid communication with the recycle line at a location between the pump and the recycle valve ; h. a dispensing valve in the dispensing line ; characterised in that ; i. the system comprises a basin defining an area configured to hold cryogenic liquid at a height raised above a bottom portion of the tank , and being in liquid communication with the tank ; j. the recycle line is in liquid communication with the pump and the basin ; k. the recycle valve is located in the recycle line between the pump and the basin ; l. a second supply line in liquid communication with a bottom portion of the basin and the pump ; and m. a second supply valve located in the second supply line between the bottom portion of the basin and the pump .
A T cell comprising exogenous nucleic acid, wherein: (a) the nucleic acid comprises a first nucleic acid sequence encoding a chimeric antigen receptor (CAR) comprising an extracellular domain, a transmembrane domain, and an intracellular signaling domain, and (b) the nucleic acid comprises a second nucleic acid sequence encoding a polypeptide which enhances T cell priming, wherein: the T cell has enhanced T cell priming ability relative to a T cell which lacks the second nucleic acid sequence, and the polypeptide is selected from the group consisting of CD70, CD86, and CD252, and functional fragments and variants of CD70, CD86 and CD252 that retain the ability to enhance T cell priming, wherein the first and/or second nucleic acid sequence is an RNA, further wherein said first and/or second RNA is transiently expressed. (a) the nucleic acid comprises a first nucleic acid sequence encoding a chimeric antigen receptor (CAR) comprising an extracellular domain, a transmembrane domain, and an intracellular signaling domain, and (b) the nucleic acid comprises a second nucleic acid sequence encoding a polypeptide which enhances T cell priming, wherein: the T cell has enhanced T cell priming ability relative to a T cell which lacks the second nucleic acid sequence, and the polypeptide is selected from the group consisting of CD70, CD86, and CD252, and functional fragments and variants of CD70, CD86 and CD252 that retain the ability to enhance T cell priming, wherein the first and/or second nucleic acid sequence is an RNA, further wherein said first and/or second RNA is transiently expressed. the T cell has enhanced T cell priming ability relative to a T cell which lacks the second nucleic acid sequence, and the polypeptide is selected from the group consisting of CD70, CD86, and CD252, and functional fragments and variants of CD70, CD86 and CD252 that retain the ability to enhance T cell priming, wherein the first and/or second nucleic acid sequence is an RNA, further wherein said first and/or second RNA is transiently expressed.
A method for processing a product by using a heat treatment apparatus for heat treating a product in a number of sections of the heat treatment apparatus , said number of sections comprising at least a first heating section , a second heating section , the heat treatment apparatus comprising a valve arrangement that comprises a number of valves, the valve arrangement being configured to be in a first mode and a second mode, wherein in the first mode, a number of the sections are configured to be passed by the product in a first order, and in the second mode, said number of the sections are configured to be passed by the product in a second order, the first order being different from the second order, the heat treatment apparatus being, by using the valve arrangement , configured to be in a first mode or in a second mode, wherein, in the first mode of the heat treatment apparatus, said number of the sections are configured to be passed by the product in a first order that comprises the first heating section being followed by the second heating section , and in the second mode of the heat treatment apparatus, said number of sections are configured to be passed by the product in a second order that comprises the second heating section being followed by the first heating section , characterised in that the method comprises, in the second mode of the heat treatment apparatus, deactivating the second heating section by redirecting a heat transfer media using a valve .
An adjustable brake controller of an elevator brake , comprising: - a DC bus (B); - first terminals for connecting the brake controller to a first magnetizing coil (9, L1); - second terminals for connecting the brake controller to a second magnetizing coil (9, L2); - a first controllable power switch coupled between the first terminals and the DC bus (B), the first controllable power switch being configured to supply electric power from the DC bus (B) to the first magnetic coil (9, L1) responsive to a first control signal (BW2A); - a second controllable power switch coupled between the second terminals and the DC bus (B), the second controllable power switch being configured to supply electric power from the DC bus (B) to the second magnetizing coil (9, L2) responsive to a second control signal (BW2B); and - a controller configured to generate the first and the second control signals (BW2A, BW2B) for controlling the first and second power switches , respectively, characterised by the controller having ∘ a brake open mode, wherein the first and second control signals (BW2A, BW2B) have a same pattern, and ∘ a brake holding mode wherein the first and second control signals (BW2A, BW2B) have a different pattern. - a DC bus (B); - first terminals for connecting the brake controller to a first magnetizing coil (9, L1); - second terminals for connecting the brake controller to a second magnetizing coil (9, L2); - a first controllable power switch coupled between the first terminals and the DC bus (B), the first controllable power switch being configured to supply electric power from the DC bus (B) to the first magnetic coil (9, L1) responsive to a first control signal (BW2A); - a second controllable power switch coupled between the second terminals and the DC bus (B), the second controllable power switch being configured to supply electric power from the DC bus (B) to the second magnetizing coil (9, L2) responsive to a second control signal (BW2B); and - a controller configured to generate the first and the second control signals (BW2A, BW2B) for controlling the first and second power switches , respectively, characterised by the controller having ∘ a brake open mode, wherein the first and second control signals (BW2A, BW2B) have a same pattern, and ∘ a brake holding mode wherein the first and second control signals (BW2A, BW2B) have a different pattern. ∘ a brake open mode, wherein the first and second control signals (BW2A, BW2B) have a same pattern, and ∘ a brake holding mode wherein the first and second control signals (BW2A, BW2B) have a different pattern.
A dissuader for animals comprising - an emitter of at least one sound emission to fend off said animal ; characterised in that - said sound emission comprises at least one main sound wave comprising a first emission period at a first frequency substantially ranging between 18 and 21 KHz; a second emission period at a frequency variable from said first to a second frequency substantially ranging between 27 and 30 KHz; a third emission period at said second frequency; a fourth emission period at a frequency variable from said second frequency to said first frequency. - an emitter of at least one sound emission to fend off said animal ; - said sound emission comprises at least one main sound wave comprising a first emission period at a first frequency substantially ranging between 18 and 21 KHz; a second emission period at a frequency variable from said first to a second frequency substantially ranging between 27 and 30 KHz; a third emission period at said second frequency; a fourth emission period at a frequency variable from said second frequency to said first frequency.
A method in a vehicle for transferring playback of media content between a mobile device and the vehicle, the method being performed by the vehicle, and the method comprising: detecting (s110) the playback of the media content on the mobile device with a microphone of the vehicle; retrieving (s120) the media content played back on the mobile device from an identified content source; playing back (s130) the retrieved media content at the vehicle in synchronization with the playback of the media content on the mobile device, wherein synchronization is achieved by a frame count of the media content or by a timestamp that indicates a frame number; sending (s140) to the mobile device a first message instructing the mobile device to pause its playback of the media content; sending (s170) to the mobile device a second message instructing the mobile device to resume its playback of the media content, if it is detected that the vehicle arrives at a predefined destination by means of Global Positioning system, GPS, Cloud services, or Connected Vehicle Cloud, CVC; and ending (s180) the playback of the media content by the vehicle. detecting (s110) the playback of the media content on the mobile device with a microphone of the vehicle; retrieving (s120) the media content played back on the mobile device from an identified content source; playing back (s130) the retrieved media content at the vehicle in synchronization with the playback of the media content on the mobile device, wherein synchronization is achieved by a frame count of the media content or by a timestamp that indicates a frame number; sending (s140) to the mobile device a first message instructing the mobile device to pause its playback of the media content; sending (s170) to the mobile device a second message instructing the mobile device to resume its playback of the media content, if it is detected that the vehicle arrives at a predefined destination by means of Global Positioning system, GPS, Cloud services, or Connected Vehicle Cloud, CVC; and ending (s180) the playback of the media content by the vehicle.
Method for producing a high-strength ferritic austenitic duplex stainless steel with the TRIP (Transformation induced plasticity) effect with deformation, characterized in that after a first heat treatment on the temperature range of 950 - 1150 °C in order to have high tensile strength level of at least 1000 MPa with retained formability, the ferritic austenitic duplex stainless steel having one of compositions A or B, whereby composition A contains in weight %: less than 0,05 % carbon (C), 0,2-0,7 % silicon (Si), 2-5 % manganese (Mn), 19-20,5 % chromium (Cr), 0,8-1,5 % nickel (Ni), less than 0,6 % molybdenum (Mo), less than 1 % copper (Cu), 0,16-0,26 % nitrogen (N), the sum C+N being 0,2 - 0,29 %, less than 0,010 weight % S, less than 0,040 weight % P so that the sum (S+P) is less than 0,04 weight %, and the total oxygen (O) below 100 ppm, and optionally contains one or more added elements; 0-0,5 % tungsten (W), 0-0,2 % niobium (Nb), 0-0,1 % titanium (Ti), 0-0,2 % vanadium (V), 0-0,5 % cobalt (Co), 0-50 ppm boron (B), and 0-0,04 % aluminium (Al), the balance being iron (Fe) and inevitable impurities occurring in stainless steels, and composition B contains in weight %: less than 0,04 % carbon (C), less than 0,7 % silicon (Si), less than 2,5 weight % manganese (Mn), 18,5-22,5 % chromium (Cr), 0,8-4,5 % nickel (Ni), 0,6-1,4 % molybdenum (Mo), less than 1 % copper (Cu), 0,10-0,24 % nitrogen (N), optionally one or more added elements: less than 0,04 % aluminium (Al), preferably less than 0,03 % aluminium (Al), less than 0,003 % boron (B), less than 0,003 % calcium (Ca), less than 0,1 % cerium (Ce), up to 1 % cobalt (Co), up to 0,5 % tungsten (W), up to 0,1 % niobium (Nb), up to 0,1 % titanium (Ti), up to 0,2 % vanadium (V), the rest being iron (Fe) and inevitable impurities occurring in stainless steels; is deformed with a reduction degree of at least 10 %, preferably at least 20 %, and that after deformation a second heat treatment is carried out within the temperature range of 100 °C - 450 °C for a period of 1 second - 20 minutes to further improve yield strength with a reduction degree of 20 % the elongation (A50) is at least 15 %. less than 0,04 % carbon (C), less than 0,7 % silicon (Si), less than 2,5 weight % manganese (Mn), 18,5-22,5 % chromium (Cr), 0,8-4,5 % nickel (Ni), 0,6-1,4 % molybdenum (Mo), less than 1 % copper (Cu), 0,10-0,24 % nitrogen (N), optionally one or more added elements: less than 0,04 % aluminium (Al), preferably less than 0,03 % aluminium (Al), less than 0,003 % boron (B), less than 0,003 % calcium (Ca), less than 0,1 % cerium (Ce), up to 1 % cobalt (Co), up to 0,5 % tungsten (W), up to 0,1 % niobium (Nb), up to 0,1 % titanium (Ti), up to 0,2 % vanadium (V), the rest being iron (Fe) and inevitable impurities occurring in stainless steels; is deformed with a reduction degree of at least 10 %, preferably at least 20 %, and that after deformation a second heat treatment is carried out within the temperature range of 100 °C - 450 °C for a period of 1 second - 20 minutes to further improve yield strength with a reduction degree of 20 % the elongation (A50) is at least 15 %.
A laminated rotor core for a rotor of an electric machine, which is constructed from a plurality of stacked lamination rings , wherein a plurality of receiving openings for permanent magnets are formed in pairs, distributed in a V-shape relative to one another in the circumferential direction (U) and symmetrically to an axis of symmetry (S1) in each of the lamination rings ; wherein a plurality of structural elements are formed homogeneously and at the same distance from one another in the circumferential direction (U) in each of the lamination rings rotated by an angle with respect to the axis of symmetry (S1), so that the arrangement of the structural elements is not symmetrical to the axis of symmetry (S1) of the lamination ring , characterized in that the laminated rotor core comprises a lamination ring or a group of lamination rings rotated by 180° about the axis of symmetry (S1) and a non-rotated lamination ring or a non-rotated group of lamination rings , wherein the rotated lamination ring or group of lamination rings sits on the non-rotated lamination ring or non-rotated group of lamination rings .
A method of producing a coating liquid impregnated sheet-like reinforcing fiber bundle , comprising allowing a sheet-like reinforcing fiber bundle , which is unidirectionally arranged reinforcing fibers , to pass substantially vertically downward through the inside of a coating section storing a coating liquid , whereby the method provides said sheet-like reinforcing fiber bundle with said coating liquid; wherein said coating section includes a liquid pool and a narrowed section which are in communication with each other; wherein said liquid pool has a portion whose cross-sectional area decreases continuously along a running direction of said sheet-like reinforcing fiber bundle, wherein said narrowed section has a slit-like cross-section and has a smaller cross-sectional area than the top side of said liquid pool and has an outlet , wherein said narrowed section communicates between the lower portion of said liquid pool and the outlet and wherein said coating section comprises, in said liquid pool, a width regulation mechanism for regulating the width of said sheet-like reinforcing fiber bundle, wherein the relationship between the width (W) of said sheet-like reinforcing fiber bundle immediately under said narrowed section and the width (L2) regulated by said width regulation mechanism at the lower end of said width regulation mechanism satisfies L2 ≤ W + 10 (mm). wherein said coating section includes a liquid pool and a narrowed section which are in communication with each other; wherein said liquid pool has a portion whose cross-sectional area decreases continuously along a running direction of said sheet-like reinforcing fiber bundle, wherein said narrowed section has a slit-like cross-section and has a smaller cross-sectional area than the top side of said liquid pool and has an outlet , wherein said narrowed section communicates between the lower portion of said liquid pool and the outlet and wherein said liquid pool has a portion whose cross-sectional area decreases continuously along a running direction of said sheet-like reinforcing fiber bundle, wherein said narrowed section has a slit-like cross-section and has a smaller cross-sectional area than the top side of said liquid pool and has an outlet , wherein said narrowed section communicates between the lower portion of said liquid pool and the outlet and wherein said coating section comprises, in said liquid pool, a width regulation mechanism for regulating the width of said sheet-like reinforcing fiber bundle, wherein the relationship between the width (W) of said sheet-like reinforcing fiber bundle immediately under said narrowed section and the width (L2) regulated by said width regulation mechanism at the lower end of said width regulation mechanism satisfies L2 ≤ W + 10 (mm).
Procedure for inspecting railway wheels with respect to use-related wear and/or a material defect, in which the railway wheel installed in a railway vehicle is tested while this railway vehicle is in motion, characterised in that the rolling railway wheelset passes through a spatially restricted magnetic field that is coupled through the rails along which the allocated rail vehicle is guided by functionally using a track portion as an electromagnet and analysing the magnetic flux through the rolling wheel, wherein the wheelset, track and magnetic yoke form a magnetic circuit between the right and left rails.