(AMENDED) A compound of formula I with improved solubility and altered pharmacokinetic properties wherein DX- is an active pharmaceutical ingredient (API) or a drug substance and; X is O; Z is selected from I-, mesylate, tosylate, or tetrafluoroborate; wherein the compound is selected from the group consisting of (A) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium iodide; (B) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Mesylate; (C) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Tetrafluoroborate; (D) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-,4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy. clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo,-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Tosylate; (E) 3-((( -1-(( -12b-acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a.8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-((tert-butoxycarbonyl)amino)-1-oxo-3-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium iodide. DX- is an active pharmaceutical ingredient (API) or a drug substance and; X is O; Z is selected from I-, mesylate, tosylate, or tetrafluoroborate; (A) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium iodide; (B) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Mesylate; (C) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Tetrafluoroborate; (D) 3-((( -1-benzamido-3-(( -6,12b-diacetoxy-12-(benzoyloxy)-,4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy. clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-oxo,-1-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium Tosylate; (E) 3-((( -1-(( -12b-acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a.8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocy-clodeca benzo[1,2-b]oxet-9-yl)oxy)-3-((tert-butoxycarbonyl)amino)-1-oxo-3-phenylpropan-2-yl)oxy)carbonyl)-1-methylpyridin-1-ium iodide. <EOS>