A method for monitoring a biological process, the method comprising: - obtaining an abnormal tissue mask from an abnormal tissue segmentation of an image of an object comprising tissue to be analyzed, said image being acquired at a time t0 called reference time point; - registering other images of the object onto the abnormal tissue mask, said other images being acquired at other time points; - normalizing image contrasts of said other images with respect to the contrasts of the image acquired at the reference time point; - subtracting the normalized images for each available contrast of a palette of available image contrasts, wherein the available contrasts refer to the different weightings in MRI or images in CT with and without contrast agent, in order to obtain difference images, wherein in case the abnormal tissue is shown as hyperintense signal in one of said available contrasts, then the normalized image is subtracted from the image acquired at the reference time point for calculating said difference images, and in case the abnormal tissue is shown as hypointense signal in one of said available contrasts, then the image acquired at the reference time point is subtracted from the normalized image, wherein all obtained difference images are scaled between 0 and 1; - creating a joint difference image by summing the previously obtained difference images; - creating a biological process progression map by overlapping the abnormal tissue mask obtained and the joint difference image after applying a predefined threshold, wherein tissue voxels within the abnormal tissue mask with intensity equal or higher to the predefined threshold on the joint difference image are considered as representing an abnormal change in the tissue and are assigned to a class of a biological process. - obtaining an abnormal tissue mask from an abnormal tissue segmentation of an image of an object comprising tissue to be analyzed, said image being acquired at a time t0 called reference time point; - registering other images of the object onto the abnormal tissue mask, said other images being acquired at other time points; - normalizing image contrasts of said other images with respect to the contrasts of the image acquired at the reference time point; - subtracting the normalized images for each available contrast of a palette of available image contrasts, wherein the available contrasts refer to the different weightings in MRI or images in CT with and without contrast agent, in order to obtain difference images, wherein in case the abnormal tissue is shown as hyperintense signal in one of said available contrasts, then the normalized image is subtracted from the image acquired at the reference time point for calculating said difference images, and in case the abnormal tissue is shown as hypointense signal in one of said available contrasts, then the image acquired at the reference time point is subtracted from the normalized image, wherein all obtained difference images are scaled between 0 and 1; - creating a joint difference image by summing the previously obtained difference images; - creating a biological process progression map by overlapping the abnormal tissue mask obtained and the joint difference image after applying a predefined threshold, wherein tissue voxels within the abnormal tissue mask with intensity equal or higher to the predefined threshold on the joint difference image are considered as representing an abnormal change in the tissue and are assigned to a class of a biological process. <EOS>