mhurhangee/patent-ind-claim-en huggingface dataset:
A monoclonal antibody against HMGB1, the antibody having any one of the following features (a) and (b) : (a) comprising a light chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 4 to 6, respectively, and a heavy chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 10 to 12, respectively; and (b) comprising a light chain variable region comprising an amino acid sequence of SEQ ID NO: 3 or the amino acid sequence of SEQ ID NO: 3 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted, and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 9 or the amino acid sequence of SEQ ID NO: 9 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted. (a) comprising a light chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 4 to 6, respectively, and a heavy chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 10 to 12, respectively; and a light chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 4 to 6, respectively, and a heavy chain variable region comprising complementarity-determining regions 1-3 as defined by amino acid sequences of SEQ ID NOs: 10 to 12, respectively; and (b) comprising a light chain variable region comprising an amino acid sequence of SEQ ID NO: 3 or the amino acid sequence of SEQ ID NO: 3 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted, and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 9 or the amino acid sequence of SEQ ID NO: 9 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted. a light chain variable region comprising an amino acid sequence of SEQ ID NO: 3 or the amino acid sequence of SEQ ID NO: 3 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted, and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 9 or the amino acid sequence of SEQ ID NO: 9 in which 1 to 10 amino acids in the framework region are substituted, deleted, added, and/or inserted.
Method for manufacturing concrete, mortar or grout, comprising the step of allowing a mixture of an aggregate material suitable for the manufacturing of concrete, mortar or grout, a binding agent and water to set, wherein the binding agent consists essentially of lignite fly ash having a sulphate content of 6 weight percent (wt.%) or higher, based on the weight of the lignite fly ash, and wherein the aggregate material and the lignite fly ash are present in the mixture in a weight ratio of between 2:1 and 10:1.
A cutting tool comprising a cemented carbide substrate comprising WC and a binder phase comprising one or more of Co, Fe and Ni wherein the cemented carbide also comprises eta phase comprising Me 12 C and/or Me 6 C carbides where Me is one or more metals selected from W, Mo and the binder phase metals wherein the substoichiometric carbon content in the cemented carbide is between -0.30 to -0.16 wt% wherein the substoichiometric carbon is the total carbon content determined by chemical analysis minus the calculated stoichiometric carbon content, where the calculation of the stoichiometric carbon content is based on the assumption that the WC and possible other carbides present in the cemented carbide are stoichiometric.
An aerodynamic configuration adjuster arranged on an outer surface of an enclosure structure, wherein the aerodynamic configuration adjuster has a grid-like structure configured to surround the enclosure structure, the grid-like structure comprises a plurality of grid cells, at least part of the grid cells have an oblique side, and an attack angle changes when a fluid passes through the oblique side; the aerodynamic configuration adjuster comprises a plurality of layers of vertically distributed adjustment grid layers , characterised in that the aerodynamic configuration adjuster further comprises at least one decoupling grid layer , and the at least one decoupling grid layer is provided between two adjustment grid layers arranged in an upper and lower directior, whereby the shape of the grid cells of the decoupling grid layer and the adjustment grid layers are different.
A system for converting an AC input voltage into a rectified output voltage, comprising: first and second transistors arranged in a first transistor pair, third and fourth transistors arranged in a second transistor pair, and a controller responsive to the input voltage and the output voltage to control switching of the first, second, third and fourth transistors , the controller being configured to control transistors in the first transistor pair in accordance with polarity of the AC input signal, and to control the third transistor based on a voltage across the third transistor and to control the fourth transistor based on a voltage across the fourth transistor , the controller including an AC polarity detect circuit for determining the polarity of the AC input voltage to produce a first enabling signal (ENA) that enables the first transistor to t urn on, wherein the AC polarity detect circuit is further configured to produce a second enabling signal (ENB) that enables the second transistor to turn on, the controller being configured to prevent the second transistor from turning on when the first transistor is on. first and second transistors arranged in a first transistor pair, third and fourth transistors arranged in a second transistor pair, and a controller responsive to the input voltage and the output voltage to control switching of the first, second, third and fourth transistors , the controller being configured to control transistors in the first transistor pair in accordance with polarity of the AC input signal, and to control the third transistor based on a voltage across the third transistor and to control the fourth transistor based on a voltage across the fourth transistor , the controller including an AC polarity detect circuit for determining the polarity of the AC input voltage to produce a first enabling signal (ENA) that enables the first transistor to t urn on, wherein the AC polarity detect circuit is further configured to produce a second enabling signal (ENB) that enables the second transistor to turn on, the controller being configured to prevent the second transistor from turning on when the first transistor is on.
Wound dressing comprising - a backing layer comprising a water vapour-permeable and substantially liquid-impermeable film material, - an absorbent pad having an absorbent core , wherein the absorbent pad comprises an envelope surrounding the absorbent core , - a wound contact layer comprising a layer of skin-friendly silicone adhesive and apertures , each of the apertures having an average area of from 0,03 mm 2 to 7,00 mm 2 , - a distribution layer , which is arranged between the wound contact layer and the absorbent core , characterized in that the entire open area of the wound contact layer formed by the apertures is between 10 % and 30 %. - a backing layer comprising a water vapour-permeable and substantially liquid-impermeable film material, - an absorbent pad having an absorbent core , wherein the absorbent pad comprises an envelope surrounding the absorbent core , - a wound contact layer comprising a layer of skin-friendly silicone adhesive and apertures , each of the apertures having an average area of from 0,03 mm 2 to 7,00 mm 2 , - a distribution layer , which is arranged between the wound contact layer and the absorbent core ,
A plate heat exchanger for treatment of a feed, the plate heat exchanger including a plate package comprising a plurality of heat exchanging plates arranged in a successive order forming alternating first and second plate interspaces, each first plate interspace define a condensation section for condensing vaporized feed, each condensation section defining an upper border, a lower border, an inlet for introducing vaporized feed into the condensation section between the upper border and the lower border, and an outlet for removing condensed feed from the condensation section at the lower border, each heat exchanging plate being provided with corrugations in the condensing section forming ridges and valleys extending in opposite directions, the ridges of opposing heat exchanging plates form a cross shaped pattern in the first plate interspaces, wherein the plate interspaces further comprising an evaporation section that can be, in use, heated by a heating volume arranged to permit evaporation of at least a part of the feed, and a separation section being arranged to separate non-vaporized feed from vaporized feed, the separation section communicating with the condensation section for supplying vaporized feed to the inlet, the plate heat exchanger being characterized in that the condensation section defines a passage extending at least a part of the distance between the upper border and the outlet, the ridges of each heat exchanging plate outside the passage extend to a contact plane allowing opposing heat exchanging plates to abut at contact points in the contact plane, whereas the ridges of each heat exchanging plate within the passage are spaced apart from the contact plane preventing contact between heat exchanging plates in the passage.
A shampoo composition comprising: a) a silicone polymer comprising: i. one or more quaternary groups; ii. at least one silicone block comprising from 300 to 600 siloxane units; iii. at least one polyalkylene oxide structural unit; and iv. at least one terminal ester group wherein said silicone polymer has a viscosity from 500 to 20,000 mPa.s, measured at 20°C and a shear rate of 0,1 s -1 with a plate-plate system, plate diameter 40mm, gap width 0.5mm, wherein said silicone polymer is a pre-emulsified dispersion with a particle size of less than 1 micron, and b) a detersive surfactant comprising an anionic, amphoteric, or zwitterionic surfactant or mixtures thereof. a) a silicone polymer comprising: i. one or more quaternary groups; ii. at least one silicone block comprising from 300 to 600 siloxane units; iii. at least one polyalkylene oxide structural unit; and iv. at least one terminal ester group wherein said silicone polymer has a viscosity from 500 to 20,000 mPa.s, measured at 20°C and a shear rate of 0,1 s -1 with a plate-plate system, plate diameter 40mm, gap width 0.5mm, wherein said silicone polymer is a pre-emulsified dispersion with a particle size of less than 1 micron, and i. one or more quaternary groups; ii. at least one silicone block comprising from 300 to 600 siloxane units; iii. at least one polyalkylene oxide structural unit; and iv. at least one terminal ester group b) a detersive surfactant comprising an anionic, amphoteric, or zwitterionic surfactant or mixtures thereof.
Running gear for a rail vehicle, having at least a first pair of wheels or at least a first wheelset, and an active wheel control system or wheelset control system, wherein at least one actuator unit is arranged on the running gear, characterised in that connected operatively parallel to the actuator unit , at least one passive resilient bearing which has increased dynamic stiffness and frequency- and amplitude-dependent static stiffness is arranged with respect to a wheel pair guidance or wheel set guidance, in that the actuator unit , which is under quasi-static load, exerts an actuating function on the position and in particular the orientation of the first pair of wheels or the first wheelset, and in that the resilient bearing couples the first pair of wheels or the first wheelset with a dynamic stiffness.
Ultrasound system , in particular for cardiac monitoring, comprising - a transducer array with a plurality of transducer array elements ; - a control unit , which is coupled to the transducer array , for controlling the transducer array ; - a data processing unit for receiving data from the transducer array and processing the received data; and - a deformation correction module , which is configured to perform a deformation correction step, based on deformation information determined for the transducer array , wherein the transducer array is a 2-dimensional transducer array, wherein at least one sub-array of transducer array elements is defined and controlled as a functional unit for sending ultrasound pulses and/or receiving ultrasound signals, and wherein said at least one sub-array is dynamically defined and capable of changing its position. - a transducer array with a plurality of transducer array elements ; - a control unit , which is coupled to the transducer array , for controlling the transducer array ; - a data processing unit for receiving data from the transducer array and processing the received data; and - a deformation correction module , which is configured to perform a deformation correction step, based on deformation information determined for the transducer array , wherein the transducer array is a 2-dimensional transducer array, wherein at least one sub-array of transducer array elements is defined and controlled as a functional unit for sending ultrasound pulses and/or receiving ultrasound signals, and wherein said at least one sub-array is dynamically defined and capable of changing its position. wherein the transducer array is a 2-dimensional transducer array, wherein at least one sub-array of transducer array elements is defined and controlled as a functional unit for sending ultrasound pulses and/or receiving ultrasound signals, and wherein said at least one sub-array is dynamically defined and capable of changing its position.
A neuronal activity enhancer compound said compound having general formula II or a pharmaceutically acceptable salt thereof wherein said compound is a catecholaminergic enhancer compound which enhances impulse propagation mediated release of a catecholamine neurotransmitter from catecholaminergic neurons in the central nervous system, for use in preventing or treating a cancer or a metastasis thereof in a mammal in a daily dose lower than 0.01 mg per kg body weight wherein this is a specific enhancer dose, which stimulates enhancer-sensitive neurons in the brain and having a specific enhancer effect thereon, wherein in formula II Q is a group consisting of a substituted or unsubstituted, aromatic, six-membered ring which may or may not have one or two heteroatoms, wherein if Q is substituted, said substituent is selected from the group consisting of hydrogen, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy and halogen, preferably Q is substituted with one or two substituent(s) or is unsubstituted, R 1 is a C 1-5 alkyl, preferably is methyl, ethyl or propyl; R 2 is C 1-4 alkyl, C 2-4 alkenyl or C 2-4 alkynyl; R 3 is hydrogen, methyl or ethyl. Q is a group consisting of a substituted or unsubstituted, aromatic, six-membered ring which may or may not have one or two heteroatoms, wherein if Q is substituted, said substituent is selected from the group consisting of hydrogen, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy and halogen, preferably Q is substituted with one or two substituent(s) or is unsubstituted, R 1 is a C 1-5 alkyl, preferably is methyl, ethyl or propyl; R 2 is C 1-4 alkyl, C 2-4 alkenyl or C 2-4 alkynyl; R 3 is hydrogen, methyl or ethyl.
A corner protection rail for a wall edge or ceiling edge in a room or building, said edge being formed by a plaster plate and/or plaster mass, wherein the corner protection rail with at least one first web and a second web which runs essentially perpendicularly to the first web extends along a longitudinal direction (z) from a first face end over a length to a second face end, wherein the corner protection rail can be shortened in length in accordance with the wall edge or ceiling edge, wherein the corner protection rail for the defined shortening of the corner protection rail without a length measure being applied comprises a plurality of first length markings and second length markings which are to be recognisably distinguishable from the first length markings , on a first side of the first web along the complete length of the corner protection rail , wherein the first length markings have a defined first distance (A) to one another and the second length markings a defined second distance to one another, wherein the second distance (B) is an integer multiple n of the first distance (A), wherein each n th of the first length markings has the same distance to the first face end as one of the second length markings , wherein the first and second length markings form a first length scaling which departs from a zero point on the first face end , and wherein the corner protection rail comprises a second length scaling which corresponds to the first length scaling , is with first and second length markings (19b, 21 b) and departs from a zero point on the second face end, characterised in that the length of the corner protection rail is not an integer multiple of the second length markings of the second length scaling , and the first and second length markings of the first length scaling are not aligned with the first and second length markings of the second length scaling .
Heater appliance, in particular gas burner device and/or oil burner device, having a control unit (10a; 10b) which is provided to take into account, during at least one ignition operation (12a, 13a; 12b, 13b) of a heater unit (14a; 14b), at least one operating characteristic variable which is determined during a previous heating operation (16a, 17a; 16b, 17b) of the heater unit (14a; 14b), and wherein the control unit is provided to determine the operating characteristic variable in an at least essentially controlled continuous operating state of the heater unit , wherein an "at least essentially controlled continuous operating state" is to be understood as meaning a control operating state of the heating operation in which the control unit is provided to set the heating power of the heater unit in the manner of a controller and stable operation of the heater appliance, in particular of the heater unit, occurs, characterized in that the control unit (10a; 10b) is provided for varying, in at least one ignition operation (12a, 13a; 12b, 13b) for setting a fuel/combustion air ratio, an actuation signal (54a; 54b) of a metering element (20a; 20b) for fuel and/or a metering element for combustion air proceeding from at least one starting value, wherein the starting value for the metering element for fuel corresponds to the determined operating characteristic variable minus a safety margin, and wherein the control unit (10a; 10b) is provided to compare the determined starting value with a starting value (24a, 26a; 24b, 26b) which is determined during the previous heating operation, and to adapt the starting value (24a, 26a; 24b, 26b) in the event of a deviation of the determined starting value from the previous starting value (24a, 26a; 24b, 26b) which is greater than a limiting deviation.
A centrifugal separator bowl comprising a rotor casing enclosing a separation space in which a stack of frustoconical separation discs is arranged to rotate around a vertical axis (X) of rotation, wherein the separation discs are arranged with the imaginary apex pointing to the axially lower end of the rotor casing ; a feed inlet at the axially lower end for receiving the fluid mixture to be separated; a distributor for distributing the fluid mixture from the inlet to the separation space , said distributor being arranged for guiding the fluid mixture to be separated continuously from an axially lower position at the inlet to an axially upper position in the separation space ; a light phase outlet for discharge of a separated phase of a first density and a heavy phase outlet for discharge of a separated phase of a second density higher than said first density, said heavy phase outlet being arranged at the axially upper end of the rotor casing ; at least one outlet conduit for transporting separated phase of the second density from the separation space , said conduit extending from a radially outer position of said separation space to said heavy phase outlet ; said conduit having a conduit inlet arranged at the radially outer position and a conduit outlet at a radially inner position.
A turbocharger comprising a compressor including a housing configured to accommodate a turbocharger impeller , the impeller comprising: a hub portion substantially shaped as a truncated cone that gradually increases in diameter along a rotation axis (ZC); a plurality of vane portions formed on a surface of the hub portion wherein the plurality of vane portions are configured to receive a fluid flowing along the rotation axis (ZC) and to force-feed the fluid in a radially outward direction; a plurality of grooves formed on surfaces of the vane portions , characterized in that the plurality of grooves extend in a radially outward direction in which the fluid having flowed along the rotation axis (ZC) flows during impeller rotation; the impeller comprises a plurality of crest portions formed between adjacent grooves of the plurality of grooves to protrude outwardly from the adjacent grooves and to extend along a longitudinal direction of the plurality of grooves wherein crest portions of the plurality of crest portions in a central region near the rotation axis (ZC) are relatively higher in height than crest portions of the plurality of crest portions in an outer region further away from the rotation axis (ZC); and the housing comprises a fluid swirl-regulating portion (20R; 20S; 20T) formed in a vicinity of an inflow port , the inflow port being configured to receive a fluid into the compressor, wherein the fluid swirl-regulating portion regulates swirling of the fluid along an inner surface of the compressor. a hub portion substantially shaped as a truncated cone that gradually increases in diameter along a rotation axis (ZC); a plurality of vane portions formed on a surface of the hub portion wherein the plurality of vane portions are configured to receive a fluid flowing along the rotation axis (ZC) and to force-feed the fluid in a radially outward direction; a plurality of grooves formed on surfaces of the vane portions , characterized in that the plurality of grooves extend in a radially outward direction in which the fluid having flowed along the rotation axis (ZC) flows during impeller rotation; the impeller comprises a plurality of crest portions formed between adjacent grooves of the plurality of grooves to protrude outwardly from the adjacent grooves and to extend along a longitudinal direction of the plurality of grooves wherein crest portions of the plurality of crest portions in a central region near the rotation axis (ZC) are relatively higher in height than crest portions of the plurality of crest portions in an outer region further away from the rotation axis (ZC); and the housing comprises a fluid swirl-regulating portion (20R; 20S; 20T) formed in a vicinity of an inflow port , the inflow port being configured to receive a fluid into the compressor, wherein the fluid swirl-regulating portion regulates swirling of the fluid along an inner surface of the compressor.