mhurhangee/patent-ind-claim-en huggingface dataset:
A method of producing a polypeptide, comprising: expressing a fusion protein comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) polypeptide signal sequence operably linked to a heterologous polypeptide, wherein the modified fragment of human immunoglobulin heavy chain binding protein (Bip) consists of the amino acid sequence of SEQ ID NO: 20; the amino acid sequence of SEQ ID NO: 21; the amino acid sequence of SEQ ID NO: 22; or the amino acid sequence of SEQ ID NO: 23; and recovering the heterologous polypeptide. expressing a fusion protein comprising a modified fragment of human immunoglobulin heavy chain binding protein (Bip) polypeptide signal sequence operably linked to a heterologous polypeptide, wherein the modified fragment of human immunoglobulin heavy chain binding protein (Bip) consists of the amino acid sequence of SEQ ID NO: 20; the amino acid sequence of SEQ ID NO: 21; the amino acid sequence of SEQ ID NO: 22; or the amino acid sequence of SEQ ID NO: 23; and recovering the heterologous polypeptide.
A protective cover configured for use with a biopsy device having a reusable holster and a disposable probe , the protective cover comprising: a flexible cover with a distal portion having a closed end , the flexible cover being configured to receive at least a portion of the reusable holster ; a sleeve ring configured to retain a part of the flexible cover on an outer surface of the sleeve ring with the flexible cover in a folded configuration; and a sleeve assembly including an outer retainer and an inner retainer , the inner retainer is configured to nest within the outer retainer so as to sandwich the distal portion of the flexible cover therebetween, the sleeve ring being attached to an open proximal end of the flexible cover . a flexible cover with a distal portion having a closed end , the flexible cover being configured to receive at least a portion of the reusable holster ; a sleeve ring configured to retain a part of the flexible cover on an outer surface of the sleeve ring with the flexible cover in a folded configuration; and a sleeve assembly including an outer retainer and an inner retainer , the inner retainer is configured to nest within the outer retainer so as to sandwich the distal portion of the flexible cover therebetween, the sleeve ring being attached to an open proximal end of the flexible cover .
A compound of Formula I, wherein R 1 and R 8 are independently hydrogen or C 1 - C 5 alkyl; R 2 is C 1 - C 5 alkyl; R 3 and R 5 are independently aryl, each optionally substituted with 0, 1, or multiple R 6 ; R 4 is hydrogen, R 6 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl, each optionally substituted with 0,1 or multiple R 7 ; and R 7 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl. wherein R 1 and R 8 are independently hydrogen or C 1 - C 5 alkyl; R 2 is C 1 - C 5 alkyl; R 3 and R 5 are independently aryl, each optionally substituted with 0, 1, or multiple R 6 ; R 4 is hydrogen, R 6 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl, each optionally substituted with 0,1 or multiple R 7 ; and R 7 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl.
A skin grafting system comprising: a handheld device comprising a device housing forming an interior that secures a drive system; a cartridge comprising a plurality of hollow microneedles surrounded by a peripheral housing and configured to be operated by the drive system to extend and retract past the peripheral housing into a subject to harvest tissue during a skin grafting process; and a device shield formed of a polymer extending from an interior opening to an exterior edge , wherein the interior opening is sized to extend about the peripheral housing to position the exterior edge over the device housing to inhibit ingress of fluids into the interior of the device housing from fluid about the peripheral housing of the cartridge during the skin grafting process performed using the skin grafting system . a handheld device comprising a device housing forming an interior that secures a drive system; a cartridge comprising a plurality of hollow microneedles surrounded by a peripheral housing and configured to be operated by the drive system to extend and retract past the peripheral housing into a subject to harvest tissue during a skin grafting process; and a device shield formed of a polymer extending from an interior opening to an exterior edge , wherein the interior opening is sized to extend about the peripheral housing to position the exterior edge over the device housing to inhibit ingress of fluids into the interior of the device housing from fluid about the peripheral housing of the cartridge during the skin grafting process performed using the skin grafting system .
A compound represented by the formula: wherein X 1 , X 2 , X 3 and X 4 are each independently a nitrogen atom, or CR a ; Y and Z are each independently an oxygen atom, NR b , or CR c R d ; R 1 and R 2 are each independently an optionally substituted C 1-6 alkyl group, or an optionally substituted cyclic group; or R 1 and R 2 in combination form an optionally further substituted nitrogen-containing heterocycle, together with the adjacent nitrogen atom; R 3 is an optionally substituted C 1-6 alkyl group, an optionally substituted cyclic group, a group represented by the formula: - C(=O)-R e , or a group represented by the formula: -C(=O)O-R e ; Ring A is an optionally further substituted pyrrolidine ring; R a , R c and R d are each independently a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group, or an optionally substituted C 1-6 alkoxy group; R b is a hydrogen atom, or an optionally substituted C 1-6 alkyl group; and R e is an optionally substituted C 1-6 alkyl group, or an optionally substituted cyclic group. or a salt thereof. X 1 , X 2 , X 3 and X 4 are each independently a nitrogen atom, or CR a ; Y and Z are each independently an oxygen atom, NR b , or CR c R d ; R 1 and R 2 are each independently an optionally substituted C 1-6 alkyl group, or an optionally substituted cyclic group; or R 1 and R 2 in combination form an optionally further substituted nitrogen-containing heterocycle, together with the adjacent nitrogen atom; R 3 is an optionally substituted C 1-6 alkyl group, an optionally substituted cyclic group, a group represented by the formula: - C(=O)-R e , or a group represented by the formula: -C(=O)O-R e ; Ring A is an optionally further substituted pyrrolidine ring; R a , R c and R d are each independently a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group, or an optionally substituted C 1-6 alkoxy group; R b is a hydrogen atom, or an optionally substituted C 1-6 alkyl group; and R e is an optionally substituted C 1-6 alkyl group, or an optionally substituted cyclic group.
A communication control device for controlling one or more communication nodes representing control targets, said device comprising: an acquisition unit configured to acquire first interference information indicating a first interference from communication involving a communication node that is not controlled by the communication control device and does hence not represent a control target and second interference information indicating a second interference from communication involving another communication node that is controlled by the communication control device and does hence represent a control target, with respect to each of a plurality of communication nodes representing control targets; and a classifying unit configured to classify the plurality of communication nodes into a plurality of groups related to a decision of a radio resource that a communication node is able to utilize, on the basis of the first interference information and the second interference information with respect to the plurality of communication nodes, wherein the plurality of groups are a plurality of groups corresponding to an order in which the radio resource is decided, wherein the plurality of groups include at least a first group and a second group, and wherein a communication node classified into the first group is a communication node in which a level of the first interference relative to the second interference is larger, as compared with a communication node classified into the second group. an acquisition unit configured to acquire first interference information indicating a first interference from communication involving a communication node that is not controlled by the communication control device and does hence not represent a control target and second interference information indicating a second interference from communication involving another communication node that is controlled by the communication control device and does hence represent a control target, with respect to each of a plurality of communication nodes representing control targets; and a classifying unit configured to classify the plurality of communication nodes into a plurality of groups related to a decision of a radio resource that a communication node is able to utilize, on the basis of the first interference information and the second interference information with respect to the plurality of communication nodes, wherein the plurality of groups are a plurality of groups corresponding to an order in which the radio resource is decided, wherein the plurality of groups include at least a first group and a second group, and wherein a communication node classified into the first group is a communication node in which a level of the first interference relative to the second interference is larger, as compared with a communication node classified into the second group.
A method for wireless communication at a user equipment, UE, comprising: receiving , from a base station, a message that indicates an increased number of paging opportunities for the UE, wherein the increased number of paging opportunities is greater than a nominal number of paging opportunities for the UE; monitoring a cell during one paging opportunity of the increased number of paging opportunities; identifying a paging opportunity reset condition; and resetting a discontinuous reception, DRX, cycle or a paging opportunity window, POW, duration to a nominal setting based at least in part on identifying the paging opportunity reset condition. receiving , from a base station, a message that indicates an increased number of paging opportunities for the UE, wherein the increased number of paging opportunities is greater than a nominal number of paging opportunities for the UE; monitoring a cell during one paging opportunity of the increased number of paging opportunities; identifying a paging opportunity reset condition; and resetting a discontinuous reception, DRX, cycle or a paging opportunity window, POW, duration to a nominal setting based at least in part on identifying the paging opportunity reset condition.
Method for setting up a device for treating tissue by means of at least one at least bipolar electrode having two individual electrodes arranged at an electrode spacing L, wherein the electrode spacing L is the spacing between the centroids of the individual electrodes, wherein the electrode spacing L of the bipolar electrode is specified in dependence - upon the thickness d of a dermal layer of the tissue at the location to be treated or data corresponding thereto and - upon an electrical reflection coefficient k of the tissue at the boundary of the dermal layer remote from the surface of the tissue at the location to be treated or data corresponding thereto, wherein a plurality of applicators are provided for selection, each applicator having at least one bipolar electrode and the electrode spacing L of the bipolar electrodes of the said applicators being different, and wherein the electrode spacing L is specified by specifying a particular applicator from the plurality of applicators for use, and that applicator is selected for the treatment at the treatment location, wherein the electrode spacing L is specified in dependence upon the thickness d, a computer unit being provided into which the thickness d is input by a user and the computer unit being programmed to specify the electrode spacing L in dependence upon the thickness d , and an ultrasonic thickness measurement unit is provided and the thickness d of the tissue at the location of use is measured by means of ultrasonic measurement, and an analysis unit is provided in order to determine the thickness d from the measurement data of the thickness measurement, the result of the thickness measurement being used automatically for determining the electrode spacing L. - upon the thickness d of a dermal layer of the tissue at the location to be treated or data corresponding thereto and - upon an electrical reflection coefficient k of the tissue at the boundary of the dermal layer remote from the surface of the tissue at the location to be treated or data corresponding thereto, wherein the electrode spacing L is specified by specifying a particular applicator from the plurality of applicators for use, and that applicator is selected for the treatment at the treatment location, wherein the electrode spacing L is specified in dependence upon the thickness d, a computer unit being provided into which the thickness d is input by a user and the computer unit being programmed to specify the electrode spacing L in dependence upon the thickness d , and an ultrasonic thickness measurement unit is provided and the thickness d of the tissue at the location of use is measured by means of ultrasonic measurement, and an analysis unit is provided in order to determine the thickness d from the measurement data of the thickness measurement, the result of the thickness measurement being used automatically for determining the electrode spacing L.
Method for producing a strand-shaped part, in which - a hollow profile made of metal is extruded, - the extruded metal hollow profile cools and/or is cooled, and - a single- or multi-layer plastic strand is extruded into the extruded metal hollow profile after or during its cooling, characterized in that - the plastic strand passes through a discharge tool of an extruder which is inserted into the metal hollow profile and exposed to the heat of the extruded metal hollow profile , said extruder having a discharge opening arranged within a region of the metal hollow profile in which it has cooled compared to its temperature during extrusion, and - the discharge tool is thermally coupled to the metal hollow profile and is temperature-controlled by it, and the discharge tool uses the heat from the extruded metal hollow profile without an external heat source if the discharge tool is introduced into the metal hollow profile . - a hollow profile made of metal is extruded, - the extruded metal hollow profile cools and/or is cooled, and - a single- or multi-layer plastic strand is extruded into the extruded metal hollow profile after or during its cooling, characterized in that - the plastic strand passes through a discharge tool of an extruder which is inserted into the metal hollow profile and exposed to the heat of the extruded metal hollow profile , said extruder having a discharge opening arranged within a region of the metal hollow profile in which it has cooled compared to its temperature during extrusion, and - the discharge tool is thermally coupled to the metal hollow profile and is temperature-controlled by it, and the discharge tool uses the heat from the extruded metal hollow profile without an external heat source if the discharge tool is introduced into the metal hollow profile .
A solid dispersion comprising a poly(meth)acrylate copolymer and HPMCAS, wherein the weight-by-weight ratio of ARN-509 : (poly(meth)acrylate copolymer and HPMCAS) in the solid dispersion is in the range from 1:1 to 1:10.
A composite material comprising: tin/zinc composite particles comprising tin particles and zinc particles, holding zinc particles on the surface of the tin particles, wherein a first average particle diameter, which is the average particle diameter of the zinc particles, is from 2 μm to 10 μm and a second average particle diameter, which is the average particle diameter of the tin particles, is larger than the first average particle diameter. tin/zinc composite particles comprising tin particles and zinc particles, holding zinc particles on the surface of the tin particles, wherein a first average particle diameter, which is the average particle diameter of the zinc particles, is from 2 μm to 10 μm and a second average particle diameter, which is the average particle diameter of the tin particles, is larger than the first average particle diameter.
A resin formulation comprising: a) 100 parts by weight of a resin mix comprising: (i) unsaturated polyester resin and (ii) anticontraction additive, which resin mix comprises 60 -100 parts by weight of an unsaturated polyester resin and 40 - 0 of an anticontraction additive; b) 1.1-1.8 parts by weight of a catalyst per 100 parts of resin mix, c) 3 - 5 parts by weight of a thickening agent per 100 parts of resin mix; d) 40 - 90 parts by weight of a first filler with average particle size of greater than 5 to 7 μm per 100 parts of resin mix; e) 15 - 35 parts by weight of a second filler with average particle size of 2 to 5 μm per 100 parts of resin mix; f) 5.5 - 22.5 parts by weight of a phenolic resin per 100 parts of resin mix; g) 1.5 - 2.5 parts by weight of a wetting agent per 100 parts of resin mix. a) 100 parts by weight of a resin mix comprising: (i) unsaturated polyester resin and (ii) anticontraction additive, which resin mix comprises 60 -100 parts by weight of an unsaturated polyester resin and 40 - 0 of an anticontraction additive; (i) unsaturated polyester resin and (ii) anticontraction additive, b) 1.1-1.8 parts by weight of a catalyst per 100 parts of resin mix, c) 3 - 5 parts by weight of a thickening agent per 100 parts of resin mix; d) 40 - 90 parts by weight of a first filler with average particle size of greater than 5 to 7 μm per 100 parts of resin mix; e) 15 - 35 parts by weight of a second filler with average particle size of 2 to 5 μm per 100 parts of resin mix; f) 5.5 - 22.5 parts by weight of a phenolic resin per 100 parts of resin mix; g) 1.5 - 2.5 parts by weight of a wetting agent per 100 parts of resin mix.
Handheld power tool comprising a torque coupling and a transmission for transmitting a torque, which is generated by a drive motor , to a drive shaft ; wherein the torque coupling is constructed in such a way that a coupling component covers a displacement distance in the event of the torque coupling slipping; a control unit and a sensor , wherein the sensor monitors the coupling component for a displacement and sends corresponding sensor signals to the control unit ; wherein the control unit is designed to control the drive motor depending on the sensor signals received; wherein the control unit is further designed to subject the sensor signals received to a plausibility check in order to establish whether the torque coupling is actually slipping; characterized in that the control unit assigns a first control signal , which represents a lack of movement of the coupling component , or a second control signal , which represents a movement of the coupling component , to the sensor signals; wherein the control unit is configured in such a way that it establishes a first condition for actual slipping of the torque coupling given an n-times change between the first control signal and the second control signal within a predefined maximum permissible time (tmax), where n is ≥ 2, in particular n is ≥ 3, and/or the control unit establishes a second condition for actual slipping of the torque coupling given an n-times change between the first control signal and the second control signal within a predefined minimum permissible time (tmin), where n is ≥ 2, in particular n is ≥ 3. a control unit and a sensor , wherein the sensor monitors the coupling component for a displacement and sends corresponding sensor signals to the control unit ; wherein the control unit is designed to control the drive motor depending on the sensor signals received; wherein the control unit is further designed to subject the sensor signals received to a plausibility check in order to establish whether the torque coupling is actually slipping; characterized in that the control unit assigns a first control signal , which represents a lack of movement of the coupling component , or a second control signal , which represents a movement of the coupling component , to the sensor signals; wherein the control unit is configured in such a way that it establishes a first condition for actual slipping of the torque coupling given an n-times change between the first control signal and the second control signal within a predefined maximum permissible time (tmax), where n is ≥ 2, in particular n is ≥ 3, and/or the control unit establishes a second condition for actual slipping of the torque coupling given an n-times change between the first control signal and the second control signal within a predefined minimum permissible time (tmin), where n is ≥ 2, in particular n is ≥ 3.
Method for producing semiconductor devices in a substrate , comprising at least the implementation of the following steps: - photolithography of a pattern of a reticle over a portion of a main face of the substrate , defining at least first elements of at least one of the semiconductor devices in the substrate , an exposure of the pattern of the reticle being repeated a plurality of times over the main face of the substrate in order to define the first elements of all the semiconductor devices , - photolithography of a pattern of an etch mask over all of the main face of the substrate , - etching of the photolithography patterns over the main face of the substrate into one portion of the thickness of the substrate , wherein first dicing lanes around the semiconductor devices are included in the pattern of the etch mask and/or in the pattern of the reticle , and the step of photolithography of the pattern of the etch mask over all of the main face of the substrate defines second dicing lanes defined by predetermined fracture lines of the edges of the substrate , and further comprising the implementation of a step of irradiating the substrate with a laser beam through the first and second dicing lanes , forming lines of weakness in the substrate , under the first and second dicing lanes . - photolithography of a pattern of a reticle over a portion of a main face of the substrate , defining at least first elements of at least one of the semiconductor devices in the substrate , an exposure of the pattern of the reticle being repeated a plurality of times over the main face of the substrate in order to define the first elements of all the semiconductor devices , - photolithography of a pattern of an etch mask over all of the main face of the substrate , - etching of the photolithography patterns over the main face of the substrate into one portion of the thickness of the substrate , wherein first dicing lanes around the semiconductor devices are included in the pattern of the etch mask and/or in the pattern of the reticle , and the step of photolithography of the pattern of the etch mask over all of the main face of the substrate defines second dicing lanes defined by predetermined fracture lines of the edges of the substrate , and further comprising the implementation of a step of irradiating the substrate with a laser beam through the first and second dicing lanes , forming lines of weakness in the substrate , under the first and second dicing lanes . wherein first dicing lanes around the semiconductor devices are included in the pattern of the etch mask and/or in the pattern of the reticle , and the step of photolithography of the pattern of the etch mask over all of the main face of the substrate defines second dicing lanes defined by predetermined fracture lines of the edges of the substrate , and further comprising the implementation of a step of irradiating the substrate with a laser beam through the first and second dicing lanes , forming lines of weakness in the substrate , under the first and second dicing lanes .