mhurhangee/patent-ind-claim-en huggingface dataset:
A fusion protein of an antibody, or a fusion protein of an antigen binding fragment thereof, comprising a first heavy chain and a first light chain fusion protein, wherein the light chain fusion protein comprises: a full length variable region fused to the N-terminus of the immunoglobulin light chain constant region and a fusion peptide fused to the C-terminus of the immunoglobulin light chain constant region without a linker peptide, wherein the fusion peptide consists of a cytokine, wherein the first heavy chain comprises a full length variable region fused to the N-terminus of a heavy chain constant region, and wherein the cytokine of said fusion peptide (i) is IL2, or (ii) is human IL2, or (iii) is human IL2, wherein the length of the N-terminal region of the cytokine fusion is shortened by 1 to 10 amino acids, or (iv) is an IL2 having a mutation at one or more positions corresponding in human IL2 to D20, F42, R38, N88, or Q126. a full length variable region fused to the N-terminus of the immunoglobulin light chain constant region and a fusion peptide fused to the C-terminus of the immunoglobulin light chain constant region without a linker peptide, wherein the fusion peptide consists of a cytokine, wherein the first heavy chain comprises a full length variable region fused to the N-terminus of a heavy chain constant region, and wherein the cytokine of said fusion peptide (i) is IL2, or (ii) is human IL2, or (iii) is human IL2, wherein the length of the N-terminal region of the cytokine fusion is shortened by 1 to 10 amino acids, or (iv) is an IL2 having a mutation at one or more positions corresponding in human IL2 to D20, F42, R38, N88, or Q126. (i) is IL2, or (ii) is human IL2, or (iii) is human IL2, wherein the length of the N-terminal region of the cytokine fusion is shortened by 1 to 10 amino acids, or (iv) is an IL2 having a mutation at one or more positions corresponding in human IL2 to D20, F42, R38, N88, or Q126.
An adapter for the detachable and relockable coupling of an endoscope with a camera head , comprising: - an external wall , extending along an axial direction, and an internal wall , at least partially surrounded by the external wall and extending along the same axial direction, which are connected to one another via a connecting wall extending between the internal and external wall at or in the vicinity of their first axial ends and which are arranged at at least a lateral distance from one another, so that between internal and external wall there arises a free space open at a second axial side opposite the first axial ends and - a coupling wall which at or close to a second axial end of the internal wall closes a free space , enclosed by the internal wall , so that the free space enclosed by the internal wall is open at a first axial side opposite the second axial end of the internal wall , wherein one of the free spaces is for coupling with at least one part of a distal camera-head end and wherein the other one of the free spaces is for coupling with at least one part of a proximal endoscope end , characterized in that the adapter furthermore is designed to ensure that, in a state in which the adapter is coupled with endoscope and camera head , the parts, of the proximal endoscope end and the distal camera-head end , projecting in a respective free space overlap along an axial direction of the adapter by at least 50% of an axial length of at least one of the free spaces , wherein the coupling wall has at least one optical window for optical image emergence, which window is designed to transmit radiation in the optical wave length range. - an external wall , extending along an axial direction, and an internal wall , at least partially surrounded by the external wall and extending along the same axial direction, which are connected to one another via a connecting wall extending between the internal and external wall at or in the vicinity of their first axial ends and which are arranged at at least a lateral distance from one another, so that between internal and external wall there arises a free space open at a second axial side opposite the first axial ends and - a coupling wall which at or close to a second axial end of the internal wall closes a free space , enclosed by the internal wall , so that the free space enclosed by the internal wall is open at a first axial side opposite the second axial end of the internal wall ,
Monitoring system for monitoring the control system of an autonomous vehicle , wherein the monitoring system is independent of the control system of the autonomous vehicle and is configured: to monitor the functions of the control system to detect malfunctions of the control system , and to report a detected malfunction of the control system to an external monitoring point , characterized in that the monitoring system is designed to receive reports of the start and end of each function performed by the control system from the control system, so that the monitoring system always has up-to-date information about the operating state of the autonomous vehicle and outputs an error message if inconsistencies arise from the reported information. to monitor the functions of the control system to detect malfunctions of the control system , and to report a detected malfunction of the control system to an external monitoring point , characterized in that the monitoring system is designed to receive reports of the start and end of each function performed by the control system from the control system, so that the monitoring system always has up-to-date information about the operating state of the autonomous vehicle and outputs an error message if inconsistencies arise from the reported information.
A tire comprising a tread portion having a designated mounting direction to a vehicle, wherein an outer middle land portion that is demarcated between an outer shoulder circumferential groove and an outer crown circumferential groove and that is located at an outer side of the vehicle when the tire is mounted on the vehicle, and an inner middle land portion that is demarcated between an inner shoulder circumferential groove and an inner crown circumferential groove and that is located at an inner side of the vehicle when the tire is mounted on the vehicle, are formed in the tread portion , the outer middle land portion has first outer middle sipes that extend from the outer crown circumferential groove toward the outer shoulder circumferential groove and that terminate within the outer middle land portion , the inner middle land portion has first inner middle sipes that extend from the inner shoulder circumferential groove toward the inner crown circumferential groove and that terminate within the inner middle land portion , and an angle (θ1) of each of the first outer middle sipes with respect to a tire axial direction is smaller than an angle (θ2) of each of the first inner middle sipes with respect to the tire axial direction, characterized in that the total number of the first outer middle sipes in a tire circumferential direction is smaller than the total number of the first inner middle sipes in the tire circumferential direction.
A device for cleaning containers comprising a tray mounted in rotation according to a first axis (Z1) and first means for driving the tray in rotation according to the first axis (Z1), the tray comprising at least three compartments configured to angularly compartmentalise said tray around the first axis (Z1), the cleaning device successively comprising at least one loading/unloading station , a washing station and a rinsing station , the compartments successively moving from one station to another, with a treatment time T on each station, by performing a rotation of the tray over 360°, characterised in that each compartment comprises a container holder configured to removably receive a container to be cleaned, each container holder being mounted in rotation relative to the tray according to a second axis (Z2) parallel to the first axis (Z1), second rotational drive means being configured to simultaneously drive all of the container holders in rotation over 360° according to the second axes (Z2), during the treatment time T.
A system for determining an amount of oscillating movement of a wind turbine tower , the wind turbine further comprising a non-rotating upper part supported by the tower , a rotor having a rotor axis , and a generator for generating electric power, the system comprising a sensor unit adapted to provide a rotor speed signal indicative of a rotational speed of the rotor relative to the non-rotating upper part , a filtering unit adapted to, based on the rotor speed signal provided by the sensor unit, provide a filtered signal comprising information associated with an oscillating movement of the wind turbine tower , and a processing unit adapted to determine the amount of oscillating movement based on the filtered signal provided by the filtering unit. a sensor unit adapted to provide a rotor speed signal indicative of a rotational speed of the rotor relative to the non-rotating upper part , a filtering unit adapted to, based on the rotor speed signal provided by the sensor unit, provide a filtered signal comprising information associated with an oscillating movement of the wind turbine tower , and a processing unit adapted to determine the amount of oscillating movement based on the filtered signal provided by the filtering unit.
A self-energized rising-diving adjusting device for a euphausia superba beam trawl, comprising: rising-diving adjusting apparatuses symmetrically installed on a beam , wherein the rising-diving adjusting apparatuses each comprise a fairing , a protective cover , a propeller water flow generator , a bidirectional driving motor , a rotary screw , a lifting and lowering connector and a fin , the protective cover is connected with a rear end of the fairing , the propeller water flow generator is installed inside the fairing , the bidirectional driving motor is powered by the propeller water flow generator , two ends of the rotary screw are installed on the protective cover in a vertical direction in a mode of rotating bidirectionally, the rotary screw is driven by the bidirectional driving motor to rotate, the lifting and lowering connector is assembled on the rotary screw through a thread structure, characterized in that a front end of the fin is horizontal and both sides of the fin are rotationally connected with the protective cover respectively, and a rear end of the fin is connected with the lifting and lowering connector and is driven to adjust an angle of the fin through lifting and lowering movement of the lifting and lowering connector .
A resiliently deformable joint having a proximal end , a distal end and an axis , the resiliently deformable joint comprising a helical structure comprising a plurality of integrally formed body portions , each of which body portions comprising a turn of the helical structure and being moveable relative to adjacent body portions , the resiliently deformable joint further comprising a plurality of body joint components, each of which body joint components is formed on a respective body portion such that adjacent body joint components are abuttable with one another to form a body joint , the resiliently deformable joint further comprising first and second guides extending axially from the distal end to the proximal end of the resiliently deformable joint ; characterised in that the body joint comprises a rolling joint.
A process for producing a roasted coffee bean extract, comprising adjusting a raw-material roasted coffee bean extract so as to have a Brix degree of from 10 to 40 and a pH of from 5.5 to 6.5, and subjecting the extract to a heat treatment at from 115°C to 125°C, wherein the raw-material roasted coffee bean extract is obtained from roasted coffee beans having an L value of from 19 to 29.
A thermoplastic composition comprising: (a) from 5 wt. % to 54 wt. % of at least one aromatic polycarbonate; (b) from 45 wt. % to 85 wt. % of at least one high heat resistance 3,3-bis(4-hydroxyphenyl)-2-phenylisoindolin-1-one (PPPBP)-polycarbonate copolymer; and (c) from 1 wt. % to 10 wt. % of at least one laser direct structuring additive comprising a copper salt, wherein the copper salt comprises a copper hydroxide phosphate, wherein articles comprising the composition have a heat distortion temperature higher than 150 °C as determined by ASTM D 648, and wherein all weight percent values are based on the total weight of the composition and the combined weight percent of all components does not exceed 100%. (a) from 5 wt. % to 54 wt. % of at least one aromatic polycarbonate; (b) from 45 wt. % to 85 wt. % of at least one high heat resistance 3,3-bis(4-hydroxyphenyl)-2-phenylisoindolin-1-one (PPPBP)-polycarbonate copolymer; and (c) from 1 wt. % to 10 wt. % of at least one laser direct structuring additive comprising a copper salt, wherein the copper salt comprises a copper hydroxide phosphate, wherein articles comprising the composition have a heat distortion temperature higher than 150 °C as determined by ASTM D 648, and wherein all weight percent values are based on the total weight of the composition and the combined weight percent of all components does not exceed 100%.
A multilayer film, at least one layer of the multilayer film comprising a polymer blend comprising a thermoplastic polyurethane and a cellulose ester, wherein the film layer is made by a hot melt process.
A steel sheet comprising: a chemical composition represented by, in mass%, C: 0.05% to 0.40%, Si: 2.50% to 6.00%, Mn: 1.50% to 10.00%, Acid-soluble Al: 0.01% to 1.00%, P: 0.10% or less, S: 0.01% or less, N: 0.01% or less, Ti: 0.0% to 0.2%, Nb: 0.0% to 0.2%, V: 0.0% to 0.2%, Cr: 0.0% to 1.0%, Mo: 0.0% to 1.0%, Cu: 0.0% to 1.0%, Ni: 0.0% to 1.0%, Ca: 0.00% to 0.01%, Mg: 0.00% to 0.01%, REM: 0.00% to 0.01%, Zr: 0.00% to 0.01%, and the balance: Fe and impurities, and comprising a steel microstructure represented by, in an area ratio, ferrite: 5% to 80%, a hard microstructure constituted of bainite, martensite or retained austenite or an arbitrary combination of the above: 20% to 95%, and a standard deviation of a line fraction of the hard microstructure on a line in a plane perpendicular to a thickness direction: 0.050 or less in a depth range where a depth from a surface when a thickness of a steel sheet is set as t is from 3t/8 to t/2. a chemical composition represented by, in mass%, C: 0.05% to 0.40%, Si: 2.50% to 6.00%, Mn: 1.50% to 10.00%, Acid-soluble Al: 0.01% to 1.00%, P: 0.10% or less, S: 0.01% or less, N: 0.01% or less, Ti: 0.0% to 0.2%, Nb: 0.0% to 0.2%, V: 0.0% to 0.2%, Cr: 0.0% to 1.0%, Mo: 0.0% to 1.0%, Cu: 0.0% to 1.0%, Ni: 0.0% to 1.0%, Ca: 0.00% to 0.01%, Mg: 0.00% to 0.01%, REM: 0.00% to 0.01%, Zr: 0.00% to 0.01%, and the balance: Fe and impurities, and comprising a steel microstructure represented by, in an area ratio, ferrite: 5% to 80%, a hard microstructure constituted of bainite, martensite or retained austenite or an arbitrary combination of the above: 20% to 95%, and a standard deviation of a line fraction of the hard microstructure on a line in a plane perpendicular to a thickness direction: 0.050 or less in a depth range where a depth from a surface when a thickness of a steel sheet is set as t is from 3t/8 to t/2.
A method for operating a first transceiver coupled with a second transceiver via a subscriber line , the first transceiver having components forming a transmit path and a receive path for establishing a communication channel via the subscriber line , the method comprising: detecting , prior to establishing a session, a received communication signal over the subscriber line indicative of a pre-existing session on the second transceiver; transmitting , responsive to the detection, a disruptor signal over the subscriber line to the second transceiver to disrupt the pre-existing session on the second transceiver; and establishing a new session between the first transceiver and the second transceiver. detecting , prior to establishing a session, a received communication signal over the subscriber line indicative of a pre-existing session on the second transceiver; transmitting , responsive to the detection, a disruptor signal over the subscriber line to the second transceiver to disrupt the pre-existing session on the second transceiver; and establishing a new session between the first transceiver and the second transceiver.
Handheld tool , in particular for dental purposes, for dispensing a pasty filling compound , the viscosity of which can be reduced by supplying oscillation energy, comprising • a tool shaft in the form of a tool housing, • a detachable container for the pasty filling compound , said container having an outlet nozzle at its front end, • an oscillation generator which is arranged in the tool shaft and which has an oscillating body , and • pressure generating means for exerting pressure on the pasty filling compound , wherein the oscillating body is detachably connected to the container in a central region of the latter, wherein the pressure generating means are formed in the central region of the tool shaft , and wherein the container has, in its front region, a cannula forming the outlet nozzle, wherein means for connecting the container to the oscillating body are formed at the end of the cannula . • a tool shaft in the form of a tool housing, • a detachable container for the pasty filling compound , said container having an outlet nozzle at its front end, • an oscillation generator which is arranged in the tool shaft and which has an oscillating body , and • pressure generating means for exerting pressure on the pasty filling compound , wherein the oscillating body is detachably connected to the container in a central region of the latter, wherein the pressure generating means are formed in the central region of the tool shaft , and wherein the container has, in its front region, a cannula forming the outlet nozzle, wherein means for connecting the container to the oscillating body are formed at the end of the cannula .
A headphone , comprising: a housing; an acoustic driver within the housing and configured to generate acoustic sound waves responsive to an input signal ; a tactile vibration driver within the housing and configured to generate tactile vibration sufficient to be felt by a user responsive to the input signal ; a noise cancellation unit (154; 554; 654, 655); and a filter configured to filter the input signal into a filtered input signal and to send said filtered input signal directly to the tactile vibration driver to generate tactile vibration on the one hand and to the noise cancellation unit (154; 554; 654, 655) on the other hand; the noise cancellation unit (154; 554; 654, 655) being coupled between the filter and the acoustic driver and being configured to: generate an adjustment signal (144; 544) according to a predetermined transfer function; and adjust the input signal responsive to the adjustment signal (144; 544) to transmit an output signal for reproduction by the acoustic driver ; characterized in that the predetermined transfer function is determined by comparing the filtered input signal to an incidental acoustic noise generated by the tactile vibrations of the tactile vibration driver . a housing; an acoustic driver within the housing and configured to generate acoustic sound waves responsive to an input signal ; a tactile vibration driver within the housing and configured to generate tactile vibration sufficient to be felt by a user responsive to the input signal ; a noise cancellation unit (154; 554; 654, 655); and a filter configured to filter the input signal into a filtered input signal and to send said filtered input signal directly to the tactile vibration driver to generate tactile vibration on the one hand and to the noise cancellation unit (154; 554; 654, 655) on the other hand; the noise cancellation unit (154; 554; 654, 655) being coupled between the filter and the acoustic driver and being configured to: generate an adjustment signal (144; 544) according to a predetermined transfer function; and adjust the input signal responsive to the adjustment signal (144; 544) to transmit an output signal for reproduction by the acoustic driver ; characterized in that the predetermined transfer function is determined by comparing the filtered input signal to an incidental acoustic noise generated by the tactile vibrations of the tactile vibration driver . generate an adjustment signal (144; 544) according to a predetermined transfer function; and adjust the input signal responsive to the adjustment signal (144; 544) to transmit an output signal for reproduction by the acoustic driver ; characterized in that the predetermined transfer function is determined by comparing the filtered input signal to an incidental acoustic noise generated by the tactile vibrations of the tactile vibration driver .
A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual, the method comprising: measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, wherein the one or more measured biochemical markers comprises sTNFRl; identifying, by a processor of a computing device, for each of the one or more measured biochemical markers, a difference between the one or more measured biomarker levels and a corresponding predetermined control level; and responsive to the identifying, determining, by the processor, a prediction corresponding to a relative risk of the pregnant individual having or developing GDM; wherein the prediction is positive based at least in part upon identifying a sTNFRl level which reflects a statistically significant increase in comparison to a respective control level, wherein the pregnant individual has not been previously diagnosed as diabetic, and/or the pregnant individual is within a first trimester stage of pregnancy at time of obtaining the blood sample. measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, wherein the one or more measured biochemical markers comprises sTNFRl; identifying, by a processor of a computing device, for each of the one or more measured biochemical markers, a difference between the one or more measured biomarker levels and a corresponding predetermined control level; and responsive to the identifying, determining, by the processor, a prediction corresponding to a relative risk of the pregnant individual having or developing GDM; wherein the prediction is positive based at least in part upon identifying a sTNFRl level which reflects a statistically significant increase in comparison to a respective control level, wherein the pregnant individual has not been previously diagnosed as diabetic, and/or the pregnant individual is within a first trimester stage of pregnancy at time of obtaining the blood sample.
A method for treating laundry comprising the steps of: providing a treatment composition comprising a photoactive component; contacting in an appliance said treatment composition with said laundry; and irradiating said treatment composition with visible light; characterized in that the step of irradiating said treatment composition with visible light is performed by a dispenser that comprises a source of light and a reservoir releasably containing said treatment composition and that is tool free attachable and detachable from an interior portion of the appliance . providing a treatment composition comprising a photoactive component; contacting in an appliance said treatment composition with said laundry; and irradiating said treatment composition with visible light; characterized in that the step of irradiating said treatment composition with visible light is performed by a dispenser that comprises a source of light and a reservoir releasably containing said treatment composition and that is tool free attachable and detachable from an interior portion of the appliance .