Device for the selective biological synthesis of a bone tissue arranged to allow the stabilization of a fracture or an osteoporotic bone tissue and including a graft tubular component or cannulated screw defining an axial channel or seat (AS) as well as at least one hole or slot (HS1, HS2) transversal to said axial channel or seat (AS) and in fluid communication with the latter, said device further comprising a stem or pin housable within said axial channel or seat (AS), said stem or pin having first removable engagement means externally to said stem or pin , while said graft tubular component or cannulated screw comprises second removable engagement means in said axial channel or seat (AS) arranged to removably engage said first engagement means , wherein said first engagement means extend at at least two zones of said stem or pin at a distance from each other, while said second engagement means extend at at least two areas of said tubular component or cannulated screw at a distance among them equal to the distance between said two zones of said first engagement means , so that the first engagement means engage at each extension zone a respective extension area of the second engagement means , wherein said first engagement means comprise an externally threaded section of said stem or pin , while said second engagement means comprise an internally threaded section of said tubular component or cannulated screw for the screwing engagement of said externally threaded section , and wherein said first engagement means comprise a conical or frusto-conical section externally delimited on said stem or pin , while said second engagement means comprise a conical or frusto-conical seat internally delimited by said tubular component or cannulated screw for the fitting engagement of said conical or frusto-conical section externally delimited on said stem or pin , wherein said two zones are at a distance from each other equal to at least half the length of said stem or pin , and wherein one of said two areas is at the rear end or back of said tubular component or cannulated screw characterised in that the other area is at a front end or tip of said tubular component or cannulated screw . wherein said first engagement means extend at at least two zones of said stem or pin at a distance from each other, while said second engagement means extend at at least two areas of said tubular component or cannulated screw at a distance among them equal to the distance between said two zones of said first engagement means , so that the first engagement means engage at each extension zone a respective extension area of the second engagement means , wherein said first engagement means comprise an externally threaded section of said stem or pin , while said second engagement means comprise an internally threaded section of said tubular component or cannulated screw for the screwing engagement of said externally threaded section , and wherein said first engagement means comprise a conical or frusto-conical section externally delimited on said stem or pin , while said second engagement means comprise a conical or frusto-conical seat internally delimited by said tubular component or cannulated screw for the fitting engagement of said conical or frusto-conical section externally delimited on said stem or pin , wherein said two zones are at a distance from each other equal to at least half the length of said stem or pin , and wherein one of said two areas is at the rear end or back of said tubular component or cannulated screw characterised in that the other area is at a front end or tip of said tubular component or cannulated screw . <EOS>