A diagnosis apparatus for analyzing the concentration of a disease factor in saliva, the apparatus comprising: a diagnosis device ; a detection unit which is detachably coupled to the diagnosis device , wherein the detection unit is configured to induce an electrochemical reaction of a disease factor in the saliva by the voltage applied through the diagnosis device , and provide an electric current generated by the electrochemical reaction of the disease factor; a communication unit ; and a control unit which is configured to apply a voltage to the detection unit , measure the electric current received from the detection unit , convert the measured result into a digital signal (S150), and provide the digital signal (S150) to a user terminal through the communication unit ; characterized in that the detection unit includes: a first layer (L1) which comprises an electrode; a second layer (L2) which has a nanostructure in the form of a porous metal-organic solid structure and is attached on the first layer (L1), in use to induce the electrochemical reaction of the disease factor in the saliva; a third layer (L3) which is positioned on the second layer (L2) and comprises an enzyme suitable for detecting the disease factor in the saliva; a fourth layer (L4) which is positioned on the third layer (L3) and comprises a filter configured to separate any one of the materials selected from protein, amylase, and urea that hinder the detection of glucose; and a fifth layer (L5) which is positioned on the fourth layer (L4) and comprises a composite fiber membrane, wherein the third layer (L3), in use selectively detects a disease factor that is glucose. a detection unit which is detachably coupled to the diagnosis device , wherein the detection unit is configured to induce an electrochemical reaction of a disease factor in the saliva by the voltage applied through the diagnosis device , and provide an electric current generated by the electrochemical reaction of the disease factor; a communication unit ; and a control unit which is configured to apply a voltage to the detection unit , measure the electric current received from the detection unit , convert the measured result into a digital signal (S150), and provide the digital signal (S150) to a user terminal through the communication unit ; characterized in that the detection unit includes: a first layer (L1) which comprises an electrode; a second layer (L2) which has a nanostructure in the form of a porous metal-organic solid structure and is attached on the first layer (L1), in use to induce the electrochemical reaction of the disease factor in the saliva; a third layer (L3) which is positioned on the second layer (L2) and comprises an enzyme suitable for detecting the disease factor in the saliva; a fourth layer (L4) which is positioned on the third layer (L3) and comprises a filter configured to separate any one of the materials selected from protein, amylase, and urea that hinder the detection of glucose; and a fifth layer (L5) which is positioned on the fourth layer (L4) and comprises a composite fiber membrane, wherein the third layer (L3), in use selectively detects a disease factor that is glucose. <EOS>