mhurhangee/patent-ind-claim-en huggingface dataset:
Method for producing high yield nano-in-micro (NIM) encapsulated bioactive siRNA dry powder comprising the steps of: - providing an aqueous suspension comprising polyplexes, in particular polyelectrolyte complexes, formed from at least a polyamine, and/or polyamide and/or polyester and siRNA, wherein the polyplexes are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar or providing an aqueous suspension comprising lipid nanoparticles formed from at least an ionizable cationic lipid, a helper lipid, a pegylated lipid, cholesterol and siRNA wherein the lipid nanoparticles are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar; - spray drying the aqueous suspension using a spray drying apparatus, preferably a Büchi B-290, by feeding the aqueous suspension to a spray drying atomizing nozzle and subjecting the atomized droplets to a heated gas stream of a carrier gas, preferably dried and cleaned air, in particular through a multicomponent atomizing nozzle for the suspension and an atomizing gas; - collecting a spray dried powder in an accumulation means of the spray drying apparatus characterized in that the temperature in the vicinity of an outlet opening connecting a spray drying chamber with the accumulation means during feeding of the aqueous suspension to the nozzle is controlled by temperature controlling means to be limited to an upper threshold temperature which is equal to or below a melting temperature of the respective naked siRNA such that the powder can be resuspended in water to polyplexes or polyplex suspensions or lipid nanoparticles or lipid nanoparticle suspensions which do not vary more than +/- 10% from their initial formulation before spray drying in regard to size, polydispersity and zeta potential. - providing an aqueous suspension comprising polyplexes, in particular polyelectrolyte complexes, formed from at least a polyamine, and/or polyamide and/or polyester and siRNA, wherein the polyplexes are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar or providing an aqueous suspension comprising lipid nanoparticles formed from at least an ionizable cationic lipid, a helper lipid, a pegylated lipid, cholesterol and siRNA wherein the lipid nanoparticles are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar; - spray drying the aqueous suspension using a spray drying apparatus, preferably a Büchi B-290, by feeding the aqueous suspension to a spray drying atomizing nozzle and subjecting the atomized droplets to a heated gas stream of a carrier gas, preferably dried and cleaned air, in particular through a multicomponent atomizing nozzle for the suspension and an atomizing gas; - collecting a spray dried powder in an accumulation means of the spray drying apparatus
A system comprising: a persistent storage device (105; 405), the persistent storage device (105; 405) comprising: a controller circuit ; persistent storage media (120; 425), connected to the controller circuit ; nonvolatile memory (110; 110a), connected to the controller circuit ; and volatile memory (115; 115a), connected to the controller circuit , wherein the controller circuit is configured to receive a first write request, for a first page of the persistent storage media (120; 425); store the first write request in the nonvolatile memory ; receive a second write request, for the first page of the persistent storage media (120; 425); store the second write request in the nonvolatile memory ; and flush the first write request and the second write request to the first page of the persistent storage media (120; 425). a persistent storage device (105; 405), the persistent storage device (105; 405) comprising: a controller circuit ; persistent storage media (120; 425), connected to the controller circuit ; nonvolatile memory (110; 110a), connected to the controller circuit ; and volatile memory (115; 115a), connected to the controller circuit , wherein the controller circuit is configured to a controller circuit ; persistent storage media (120; 425), connected to the controller circuit ; nonvolatile memory (110; 110a), connected to the controller circuit ; and volatile memory (115; 115a), connected to the controller circuit , wherein the controller circuit is configured to receive a first write request, for a first page of the persistent storage media (120; 425); store the first write request in the nonvolatile memory ; receive a second write request, for the first page of the persistent storage media (120; 425); store the second write request in the nonvolatile memory ; and flush the first write request and the second write request to the first page of the persistent storage media (120; 425).
A speaker module , comprising a first enclosure , a speaker core , and a waterproof breathable film , wherein the first enclosure is provided with an accommodating groove , the speaker core is mounted on the accommodating groove , the speaker core comprises a sound diaphragm , a front sound cavity is formed between the sound diaphragm and the first enclosure , a rear sound cavity is on a side that is of the sound diaphragm , and the side that is of the sound diaphragm is away from the front sound cavity ; the first enclosure is further provided with a resonant groove , a bottom of the resonant groove is provided with a communicating hole , the resonant groove communicates with the front sound cavity through the communicating hole , and the waterproof breathable film covers an opening that is of the resonant groove and that faces the rear sound cavity , to isolate the resonant groove from the rear sound cavity ; and the first enclosure is further provided with a groove , an opening of the groove is located on a bottom wall surface of the accommodating groove ; characterized in that the sound diaphragm comprises a dome and a diaphragm bearing the dome , and the dome directly faces the groove ; the dome is in a rectangular plate shape; and the diaphragm is in a rectangular ring shape. the first enclosure is further provided with a resonant groove , a bottom of the resonant groove is provided with a communicating hole , the resonant groove communicates with the front sound cavity through the communicating hole , and the waterproof breathable film covers an opening that is of the resonant groove and that faces the rear sound cavity , to isolate the resonant groove from the rear sound cavity ; and the first enclosure is further provided with a groove , an opening of the groove is located on a bottom wall surface of the accommodating groove ; characterized in that the sound diaphragm comprises a dome and a diaphragm bearing the dome , and the dome directly faces the groove ; the dome is in a rectangular plate shape; and the diaphragm is in a rectangular ring shape.
A safety belt, comprising an inelastic portion and a resiliently extendable portion attaching two points of the safety belt together, wherein the resiliently extendable portion of the belt is formed by an elasticated material, for exerting tension on a first end of the safety belt; a releasable fastening means attached to the first end of the belt and having a quick release mechanism for releasably retaining a second end of the belt when the belt is around a user; and wherein the resiliently extendable portion is proximal to the releasable fastening means such that, when the releasable fastening means is operated by a user to release the second end, the tension provided by the resiliently extendable portion pulls the releasable fastening means free from the second end; wherein the resiliently extendable portion when in an un-tensioned state is shorter than the inelastic portion such that, under no tension, an effective length of the safety belt, comprising the inelastic portion and a resiliently extendable portion, is determined by the un-tensioned length of the resiliently extendable portion; and under maximum tension, the effective length of the section of the safety belt is the length of the inelastic portion,
An apparatus for reconstructing a single media stream from a plurality of received media streams, the apparatus comprising: a RTP header parser configured to parse data packets of a plurality of media streams to identify a respective sequence number index of each of the data packets in each of the plurality of media streams; a packet sequencer validator configured to assign a flow ID to each of the plurality of media streams based on a header from each respective data packet that identifies at least one of a source IP address or a destination IP address of each of the respective media streams; a data packet recorder configured to align the plurality of media streams based on the respective flow IDs and the identified sequence number index of each of the data packets and to store a reconstructed media stream in a memory buffer based on the respective sequence number indexes; a data packet player configured to fetch the respective data packets of the reconstructed media stream stored in the memory buffer and route the fetched data packets over a packet player channel for playout of the reconstructed media stream on a media consumption device, wherein the reconstructed media stream is stored in the memory buffer without storing the plurality of media streams in separate media buffers before the data packet recorder stores the reconstructed media stream in the memory buffer. a RTP header parser configured to parse data packets of a plurality of media streams to identify a respective sequence number index of each of the data packets in each of the plurality of media streams; a packet sequencer validator configured to assign a flow ID to each of the plurality of media streams based on a header from each respective data packet that identifies at least one of a source IP address or a destination IP address of each of the respective media streams; a data packet recorder configured to align the plurality of media streams based on the respective flow IDs and the identified sequence number index of each of the data packets and to store a reconstructed media stream in a memory buffer based on the respective sequence number indexes; a data packet player configured to fetch the respective data packets of the reconstructed media stream stored in the memory buffer and route the fetched data packets over a packet player channel for playout of the reconstructed media stream on a media consumption device, wherein the reconstructed media stream is stored in the memory buffer without storing the plurality of media streams in separate media buffers before the data packet recorder stores the reconstructed media stream in the memory buffer.
A method for wireless communications, comprising: determining , based on a given location, a set of frequency resources to be used for transmitting sensor information obtained at one or more vehicles for that given location; and utilizing the set of frequency resources to transmit sensor information or monitor for sensor information. determining , based on a given location, a set of frequency resources to be used for transmitting sensor information obtained at one or more vehicles for that given location; and utilizing the set of frequency resources to transmit sensor information or monitor for sensor information.
A method for producing a liquid developer, wherein the developer comprises toner particles comprising a resin and a pigment, wherein the toner particles are dispersed in an insulating liquid, wherein the resin comprises a resin H having a softening point - as measured according to the descripton - of 100°C or higher and a resin L having a softening point - as measured according to the description - of 93°C or lower, wherein the resin H is a composite resin HC of a polyester resin and a styrenic resin, and the resin L is a composite resin LC of a polyester resin and a styrenic resin, wherein the composite resin HC and the composite resin LC are each a resin in which a polyester resin and a styrenic resin are chemically bonded via a dually reactive monomer, the method comprising: step 1: melt-kneading a resin comprising a resin H and a resin L and a pigment, and pulverizing a kneaded product obtained, to provide toner particles; step 2: adding a dispersant to the toner particles obtained in the step 1, and dispersing the toner particles in an insulating liquid to provide a dispersion of toner particles; and step 3: subjecting the dispersion of toner particles obtained in the step 2 to wet-milling, to provide a liquid developer. step 1: melt-kneading a resin comprising a resin H and a resin L and a pigment, and pulverizing a kneaded product obtained, to provide toner particles; step 2: adding a dispersant to the toner particles obtained in the step 1, and dispersing the toner particles in an insulating liquid to provide a dispersion of toner particles; and step 3: subjecting the dispersion of toner particles obtained in the step 2 to wet-milling, to provide a liquid developer.
An ex vivo method of expanding hematopoietic stem or progenitor cells, the method comprising contacting hematopoietic stem cells or progenitor cells isolated from a subject, with a morpholino oligonucleotide that inhibits the expression of a VentX polypeptide, whereby expansion of the hematopoietic stem or progenitor cells is increased, wherein the oligonucleotide has a sequence SEQ ID NO: 68 or SEQ ID NO:69.
Optical rotary joint comprising: a first collimator arrangement connected to first light waveguides ; a second collimator arrangement connected to second light waveguides , the second collimator arrangement being arranged rotatably relative to the first collimator arrangement about a rotation axis ; and a derotating optical element which is arranged in a light path between the first collimator arrangement and the second collimator arrangement ; characterized in that a first face of the derotating optical element comprises a first multiwavelength achromatic metasurface and a second face of the derotating optical element comprises a second multiwavelength achromatic metasurface , wherein the first and the second multiwavelength achromatic metasurfaces each comprise an arrangement of a plurality of subwavelength size resonators and the material of the plurality of subwavelength size resonators is glass. a first collimator arrangement connected to first light waveguides ; a second collimator arrangement connected to second light waveguides , the second collimator arrangement being arranged rotatably relative to the first collimator arrangement about a rotation axis ; and a derotating optical element which is arranged in a light path between the first collimator arrangement and the second collimator arrangement ; characterized in that a first face of the derotating optical element comprises a first multiwavelength achromatic metasurface and a second face of the derotating optical element comprises a second multiwavelength achromatic metasurface , wherein the first and the second multiwavelength achromatic metasurfaces each comprise an arrangement of a plurality of subwavelength size resonators and the material of the plurality of subwavelength size resonators is glass.
A solid gas-generating composition consisting of: - a) a binder comprising (a1) a polymer chosen from the group consisting of polyesters having a hydroxy termination, polyethers having a hydroxy termination and the mixtures thereof, and (a2) a cross-linking system; - b) an oxidising feedstock consisting of a mixture of (b1) ammonium perchlorate or ammonium chlorate or the mixture thereof with (b2) an alkali or alkaline-earth nitrate chosen from the group consisting of sodium nitrate, potassium nitrate, strontium nitrate, barium nitrate and the mixtures thereof, the content of nitrate (b2) being between 40 and 57% by weight compared with the total weight of the feedstock (b); - optionally an additive with a content between 0.1 and 10% by mass compared with the total mass of the composition. - a) a binder comprising (a1) a polymer chosen from the group consisting of polyesters having a hydroxy termination, polyethers having a hydroxy termination and the mixtures thereof, and (a2) a cross-linking system; - b) an oxidising feedstock consisting of a mixture of (b1) ammonium perchlorate or ammonium chlorate or the mixture thereof with (b2) an alkali or alkaline-earth nitrate chosen from the group consisting of sodium nitrate, potassium nitrate, strontium nitrate, barium nitrate and the mixtures thereof, the content of nitrate (b2) being between 40 and 57% by weight compared with the total weight of the feedstock (b); - optionally an additive with a content between 0.1 and 10% by mass compared with the total mass of the composition.
An oral care composition comprising: a) calcium phosphate polyionic clusters; b) glycerin; wherein the calcium phosphate polyionic clusters are obtained by a process comprising the steps of: i) dissolving a water soluble calcium source in ethanol to produce an ethanol solution A having a calcium ion concentration from 5 to 60 mmol/L; ii) dissolving phosphoric acid and triethylamine in ethanol to produce an ethanol solution B having a phosphoric acid concentration from 10 to 120 mmol/L and a triethylamine concentration from 1000 to 3900 mmol/L; iii) mixing the solution A and the solution B and standing the mixture to obtain a calcium phosphate polyionic cluster solution; iv) centrifuging the calcium phosphate polyionic cluster solution to obtain the calcium phosphate polyionic clusters wherein the water soluble calcium source is a calcium source that dissolves in water to give a concentration of at least 0.1 moles per litre at 25°C and atmospheric pressure. a) calcium phosphate polyionic clusters; b) glycerin; i) dissolving a water soluble calcium source in ethanol to produce an ethanol solution A having a calcium ion concentration from 5 to 60 mmol/L; ii) dissolving phosphoric acid and triethylamine in ethanol to produce an ethanol solution B having a phosphoric acid concentration from 10 to 120 mmol/L and a triethylamine concentration from 1000 to 3900 mmol/L; iii) mixing the solution A and the solution B and standing the mixture to obtain a calcium phosphate polyionic cluster solution; iv) centrifuging the calcium phosphate polyionic cluster solution to obtain the calcium phosphate polyionic clusters
A method , comprising: projecting a projection pattern onto a surface of an object from a projection point of a distance sensor, wherein the projection point comprises a light source and a diffractive optical element, wherein the projection pattern is created by a plurality of beams of light projected from the projection point, wherein the plurality of beams of light creates a plurality of projection artifacts that is arranged on the surface of the object; characterized in that prior to the projecting, a positional relationship between the projection point and an image capturing device of the distance sensor is adjusted by adjusting a difference in height between the projection point and a front nodal point of the image capturing device of the distance sensor in a direction of an optical axis of the image capturing device, wherein the adjusting minimizes an overlap of a plurality of trajectories, wherein each trajectory of the plurality of trajectories describes a movement of one projection artifact of the plurality of projection artifacts relative to the image capturing device with variations in distance from the surface of the object; capturing an image of the object, including at least a portion of the projection pattern; and calculating a distance from the distance sensor to the object using information from the image. projecting a projection pattern onto a surface of an object from a projection point of a distance sensor, wherein the projection point comprises a light source and a diffractive optical element, wherein the projection pattern is created by a plurality of beams of light projected from the projection point, wherein the plurality of beams of light creates a plurality of projection artifacts that is arranged on the surface of the object; characterized in that prior to the projecting, a positional relationship between the projection point and an image capturing device of the distance sensor is adjusted by adjusting a difference in height between the projection point and a front nodal point of the image capturing device of the distance sensor in a direction of an optical axis of the image capturing device, wherein the adjusting minimizes an overlap of a plurality of trajectories, wherein each trajectory of the plurality of trajectories describes a movement of one projection artifact of the plurality of projection artifacts relative to the image capturing device with variations in distance from the surface of the object; capturing an image of the object, including at least a portion of the projection pattern; and calculating a distance from the distance sensor to the object using information from the image.
A method for communicating safety data regarding an elevator installation using a serial communication channel, the method comprising a set of transmission and receipt steps comprising: a. at a serialization module : i. receiving a plurality of items of safety data for an elevator car; ii. building a serializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the serializer data package comprising the plurality of items of safety data for the elevator car to a deserialization module ; b. at the deserialization module : i. receiving the serializer data package comprising the plurality of items of safety data for the elevator car; ii. building a deserializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the deserializer data package comprising the plurality of items of safety data to a controller ; characterized in that at the controller , determining, based on information from the deserialization module, whether the elevator car should be prevented from operating as a result of a safety problem. a. at a serialization module : i. receiving a plurality of items of safety data for an elevator car; ii. building a serializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the serializer data package comprising the plurality of items of safety data for the elevator car to a deserialization module ; i. receiving a plurality of items of safety data for an elevator car; ii. building a serializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the serializer data package comprising the plurality of items of safety data for the elevator car to a deserialization module ; b. at the deserialization module : i. receiving the serializer data package comprising the plurality of items of safety data for the elevator car; ii. building a deserializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the deserializer data package comprising the plurality of items of safety data to a controller ; i. receiving the serializer data package comprising the plurality of items of safety data for the elevator car; ii. building a deserializer data package comprising the plurality of items of safety data for the elevator car; and iii. sending the deserializer data package comprising the plurality of items of safety data to a controller ;