An air filter cartridge comprising: (a) a filter media pack comprising a stacked construction of individual strips of media each comprising a fluted sheet secured to facing sheet to define inlet and outlet flow channels extending between first and second , opposite, flow surfaces; (b) a molded side panel arrangement comprising at least first and second , opposite, molded panels molded directly to, and in sealing coverage over, a first set of two opposite sides of the media pack defined by lead ends and tail ends of the strips of media; and, characterized by (c) an axial pinch housing seal arrangement ; (d) the housing seal arrangement (i) being molded onto the filter cartridge ; (ii) being provided spaced from the first surface toward the second surface ; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough , facing in the same direction as the first surface , provided along the media pack and surrounding said pack; (v) being engagable by the housing , with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge , when installed; (e) wherein by the term axial it is meant that forces are generally directed in the same direction as extension between flow faces . (a) a filter media pack comprising a stacked construction of individual strips of media each comprising a fluted sheet secured to facing sheet to define inlet and outlet flow channels extending between first and second , opposite, flow surfaces; (b) a molded side panel arrangement comprising at least first and second , opposite, molded panels molded directly to, and in sealing coverage over, a first set of two opposite sides of the media pack defined by lead ends and tail ends of the strips of media; and, characterized by (c) an axial pinch housing seal arrangement ; (d) the housing seal arrangement (i) being molded onto the filter cartridge ; (ii) being provided spaced from the first surface toward the second surface ; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough , facing in the same direction as the first surface , provided along the media pack and surrounding said pack; (v) being engagable by the housing , with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge , when installed; (i) being molded onto the filter cartridge ; (ii) being provided spaced from the first surface toward the second surface ; (iii) being positioned at a location for forming a seal with housing components, when the filter cartridge is positioned in a housing of an air cleaner for use; (iv) including a contoured surface with a recess on a trough , facing in the same direction as the first surface , provided along the media pack and surrounding said pack; (v) being engagable by the housing , with engagement into the recess, to pinch, axially, seal arrangement to seal a bypass flow around the filter cartridge , when installed; (e) wherein by the term axial it is meant that forces are generally directed in the same direction as extension between flow faces . <EOS>