mhurhangee/patent-ind-claim-en huggingface dataset:
A bogie for a railway vehicle comprising an elastic element that is configured to be arranged between a vehicle body and a bogie frame of a railway vehicle and elastically supports both, wherein the elastic element is configured in such a manner that a spring constant for displacement in the longitudinal direction in the traveling direction of the vehicle body is smaller than that for displacement in the vertical direction or the left-and-right direction in the traveling direction, wherein the elastic element is configured by stacking first elastic bodies and plates in the vertical direction, and by stacking second elastic bodies and plates in the vertical direction, the second elastic bodies having a spring constant for displacement in the longitudinal direction that is larger than that of the first elastic bodies, the elastic element being configured to be opened to the front side or the rear side and the center side with respect to the traveling direction, and wherein in the same layer between the plates of the elastic element , the first elastic bodies are arranged on each of the front side and the rear side, and the second elastic bodies are arranged on the center side. wherein the elastic element is configured in such a manner that a spring constant for displacement in the longitudinal direction in the traveling direction of the vehicle body is smaller than that for displacement in the vertical direction or the left-and-right direction in the traveling direction, wherein the elastic element is configured by stacking first elastic bodies and plates in the vertical direction, and by stacking second elastic bodies and plates in the vertical direction, the second elastic bodies having a spring constant for displacement in the longitudinal direction that is larger than that of the first elastic bodies, the elastic element being configured to be opened to the front side or the rear side and the center side with respect to the traveling direction, and wherein in the same layer between the plates of the elastic element , the first elastic bodies are arranged on each of the front side and the rear side, and the second elastic bodies are arranged on the center side.
A method for generating articular like non-hypertrophic chondrocyte cells, hypertrophic chondrocyte-like cells, or cartilage like tissue, the method comprising: a. culturing a CD56 + and PDGFRα + primitive streak-like mesoderm population for at least 1, 2, 3 or 4 days, with a paraxial mesoderm specifying cocktail comprising: i. an FGF agonist; ii. a BMP inhibitor; and iii. a TGFβ inhibitor, to generate a CD73 + CD105 + , CD73 + PDGFRβ + , or CD73 + CD105 + PDGFRβ + paraxial mesoderm population; b. culturing the paraxial mesoderm population at a high cell density with a TGFβ agonist, to produce a Sox9 + and collagen 2 + chondrocyte precursor population; and c. either i. further culturing the high cell density, Sox9 + , collagen 2 + chondrocyte precursor population with the TGFβ agonist for at least 10 days to produce articular like non-hypertrophic chondrocyte cells and/or cartilage like tissue; or ii. culturing the high cell density Sox9 + collagen 2 + chondrocyte precursor population with a BMP4 agonist for period of time of at least 3 weeks to produce hypertrophic chondrocyte like cells and/or cartilage like tissue. a. culturing a CD56 + and PDGFRα + primitive streak-like mesoderm population for at least 1, 2, 3 or 4 days, with a paraxial mesoderm specifying cocktail comprising: i. an FGF agonist; ii. a BMP inhibitor; and iii. a TGFβ inhibitor, to generate a CD73 + CD105 + , CD73 + PDGFRβ + , or CD73 + CD105 + PDGFRβ + paraxial mesoderm population; i. an FGF agonist; ii. a BMP inhibitor; and iii. a TGFβ inhibitor, b. culturing the paraxial mesoderm population at a high cell density with a TGFβ agonist, to produce a Sox9 + and collagen 2 + chondrocyte precursor population; and c. either i. further culturing the high cell density, Sox9 + , collagen 2 + chondrocyte precursor population with the TGFβ agonist for at least 10 days to produce articular like non-hypertrophic chondrocyte cells and/or cartilage like tissue; or ii. culturing the high cell density Sox9 + collagen 2 + chondrocyte precursor population with a BMP4 agonist for period of time of at least 3 weeks to produce hypertrophic chondrocyte like cells and/or cartilage like tissue. i. further culturing the high cell density, Sox9 + , collagen 2 + chondrocyte precursor population with the TGFβ agonist for at least 10 days to produce articular like non-hypertrophic chondrocyte cells and/or cartilage like tissue; or ii. culturing the high cell density Sox9 + collagen 2 + chondrocyte precursor population with a BMP4 agonist for period of time of at least 3 weeks to produce hypertrophic chondrocyte like cells and/or cartilage like tissue.
A semiconductor device , comprising: a semiconductor layer which has a first surface and a second surface which is opposite to the first surface ; a metal layer which is provided on the first surface , and which consists of only metal whose standard oxidation-reduction potential is not lower than 0 (zero) V in an ionization tendency; an electrode provided on the metal layer ; a reaction layer which is formed by reaction of the metal layer and the semiconductor layer ; an electrical conductive layer which covers an inside of a hole which is formed in the semiconductor layer so as to reach the metal layer from the second surface , and which is electrically connected to the electrode via the metal layer which is exposed to a bottom of the hole ; and a functional part comprising a plurality of source electrodes electrically connected to the electrode , and characterized in that the metal layer is provided under the electrode but not under the source electrodes . a semiconductor layer which has a first surface and a second surface which is opposite to the first surface ; a metal layer which is provided on the first surface , and which consists of only metal whose standard oxidation-reduction potential is not lower than 0 (zero) V in an ionization tendency; an electrode provided on the metal layer ; a reaction layer which is formed by reaction of the metal layer and the semiconductor layer ; an electrical conductive layer which covers an inside of a hole which is formed in the semiconductor layer so as to reach the metal layer from the second surface , and which is electrically connected to the electrode via the metal layer which is exposed to a bottom of the hole ; and a functional part comprising a plurality of source electrodes electrically connected to the electrode , and characterized in that the metal layer is provided under the electrode but not under the source electrodes .
Padded mailing envelope for receiving at least one dispatch object, wherein the mailing envelope comprises an opening for receiving the object at least on one side, wherein the mailing envelope is formed of a least one cut-to-size outer material , wherein a padded-material layer is arranged on an inner side of an outer material layer of the cut-to-size outer material facing the inner space of the mailing envelope , wherein the padded-material layer is formed of a paper foam , characterized in that the paper foam is present in the type of paper foam granules .
A method for the manufacture of a contact lens, the method comprising providing a first, concave, mould-half having a first concave mould surface to correspond with a convex surface of the contact lens, the first concave mould surface having an optic zone and a peripheral zone, the optic zone corresponding with an optic zone of the contact lens to be manufactured; providing a second, convex, mould-half having a second convex mould surface to correspond with a concave surface of the contact lens, said second mould half configured to engage with the first mould-half to define a first, pre-cure, mould cavity therebetween, which mould cavity is defined by the first, concave, mould surface and second, convex, mould surface said first and second mould surfaces having respective curvatures to correspond with a pre-determined lens power/curvature; disposing into the mould cavity a curable lens-forming fluid composition ; curing said composition to form a pre-hydrated lens ; and separating the first and second mould halves, characterized in that the first mould surface is defined by an annular ridge formed on the first mould half and in that the engagement between the mould halves is unconstrained whereby relative radial movement and relative axial movement are not prevented and the first mould half has sufficient radial flexibility such that during the curing of said composition the first mould half flexes such as to define between the first and second mould surfaces a second, post-cure, mould cavity which second post-cure mould cavity defines a smaller volume than said first pre-cure mould cavity and whereby during curing the curvature of the first mould surface, including the optic zone of the first mould surface, is allowed to change.
Use of sodium deoxycholate for the non-therapeutic, non-surgical removal of localized fat accumulation.
A device for securing a connection to be formed between a leg of a marine structure and a pile of a fundament fastened in a seabed, wherein the connection comprises the leg partly inserted into an opening of the pile , wherein the device is configured to be firmly connected to the leg , the device comprising - a sleeve element configured, together with the leg of the marine structure, to be brought to vicinity of an upper portion of the pile , and - a clamping arrangement attached to the sleeve element comprising at least one clamping device configured to form an attachment between the sleeve element and the upper portion of the pile , wherein the clamping device comprises a clamp mechanism comprising a displaceable wedge configured to form a wedged engagement with the upper portion of the pile , wherein the clamp mechanism comprises a setting member configured to act on the displaceable wedge for forming the attachment between the sleeve element and the upper portion of the pile , characterized in that the setting member comprises an axially displaceable bolt configured to act on the displaceable wedge so that the displaceable wedge is displaced into engagement with an envelope surface of the pile . wherein the device is configured to be firmly connected to the leg , the device comprising - a sleeve element configured, together with the leg of the marine structure, to be brought to vicinity of an upper portion of the pile , and - a clamping arrangement attached to the sleeve element comprising at least one clamping device configured to form an attachment between the sleeve element and the upper portion of the pile , - a sleeve element configured, together with the leg of the marine structure, to be brought to vicinity of an upper portion of the pile , and - a clamping arrangement attached to the sleeve element comprising at least one clamping device configured to form an attachment between the sleeve element and the upper portion of the pile , wherein the clamping device comprises a clamp mechanism comprising a displaceable wedge configured to form a wedged engagement with the upper portion of the pile , wherein the clamp mechanism comprises a setting member configured to act on the displaceable wedge for forming the attachment between the sleeve element and the upper portion of the pile , characterized in that the setting member comprises an axially displaceable bolt configured to act on the displaceable wedge so that the displaceable wedge is displaced into engagement with an envelope surface of the pile .
A flush toilet comprising: a toilet main body ; a base portion which is provided on an upper surface of the toilet main body and in which a function unit is installed; and a flow channel which is provided between the toilet main body and the function unit and discharges water that overflows from a toilet bowl of the toilet main body , characterized in that the flow channel is formed in the base portion and communicates with the toilet main body via a flow channel opening formed in the base portion , and that a recessed portion is formed on the upper surface of the toilet main body on which the base portion is installed. a toilet main body ; a base portion which is provided on an upper surface of the toilet main body and in which a function unit is installed; and a flow channel which is provided between the toilet main body and the function unit and discharges water that overflows from a toilet bowl of the toilet main body , characterized in that the flow channel is formed in the base portion and communicates with the toilet main body via a flow channel opening formed in the base portion , and that a recessed portion is formed on the upper surface of the toilet main body on which the base portion is installed.
A polymerized peptide that has, as a repeating unit, a triple-chain peptide having a triple-helical structure, and is polymerized by oxidative cross-linking, wherein peptide chains composing the triple-chain peptide are identical to or different from one another, and each peptide chain has: one or more triple helix forming peptidyl groups each having a repeating structure in which -(Xaa-Yaa-Gly)- as a basic unit is repeated at least 10 times, and one or more cross-link forming peptidyl groups each comprising at least two cysteine (Cys) residues within 10 residues from each of the amino-terminus and the carboxy-terminus, and wherein each of Xaa and Yaa is independently selected from a proline (Pro or P) residue, a hydroxyproline (Hyp or O) residue, an arginine (Arg or R) residue, a lysine (Lys or K) residue, a valine (Val or V) residue, a leucine (Leu or L) residue, an isoleucine (Ile or I) residue, a serine (Ser or S) residue, a threonine (Thr or T) residue, an alanine (Ala or A) residue, a glycine (Gly or G) residue, a phenylalanine (Phe or F) residue, a methionine (Met or M) residue, a glutamate (Glu or E) residue, an aspartate (Asp or D) residue, an asparagine (Asn or N) residue, a glutamine (Gln or Q) residue, a histidine (His or H) residue, a tryptophan (Trp or W) residue or a tyrosine (Tyr or Y) residue, the proline residue may be modified by an amino group or fluorine atom, and each of the Xaa position and Yaa position may employ an N-isobutyl glycine residue. one or more triple helix forming peptidyl groups each having a repeating structure in which -(Xaa-Yaa-Gly)- as a basic unit is repeated at least 10 times, and one or more cross-link forming peptidyl groups each comprising at least two cysteine (Cys) residues within 10 residues from each of the amino-terminus and the carboxy-terminus, and wherein
A battery comprising: a rectangular box-shaped battery case , an inner portion of which is sealed; a battery module housed in the battery case and being an aggregation of a plurality of battery cells ; and a tubular heat resistant sheet arranged between the battery case and the battery module in a state of covering an entire side surface of an inner wall surface of the battery case characterized in that the heat resistant sheet is made by combining four pieces of L-shaped members in a rectangular frame shape, in a state of providing portions partially overlapped side by side, the four pieces of L-shaped members each being adhered on the inner wall surface of the battery case by a double-sided tape , and the four pieces of L-shaped members each being made by bending a piece of sheet main body into an L shape. a rectangular box-shaped battery case , an inner portion of which is sealed; a battery module housed in the battery case and being an aggregation of a plurality of battery cells ; and a tubular heat resistant sheet arranged between the battery case and the battery module in a state of covering an entire side surface of an inner wall surface of the battery case characterized in that the heat resistant sheet is made by combining four pieces of L-shaped members in a rectangular frame shape, in a state of providing portions partially overlapped side by side, the four pieces of L-shaped members each being adhered on the inner wall surface of the battery case by a double-sided tape , and the four pieces of L-shaped members each being made by bending a piece of sheet main body into an L shape.
Fluid switch-over device, preferably for a sanitary water discharge faucet, comprising - a housing body which includes a fluid inlet channel and a plurality of fluid outlet channels arranged fluidically in parallel, - a switch-over body which includes a fluid inlet , at least one fluid outlet and a fluid duct from the fluid inlet to the fluid outlet and is disposed within the housing body to be translationally movable axially parallel and rotationally movable in a combined manner in relation to a longitudinal axis (L) between at least two different operating positions, wherein said switch-over body in each of the different operating positions is in fluid connection to the fluid inlet channel via its fluid inlet and differentially unblocks or blocks at least partially a fluid connection of its fluid outlet to the respective fluid outlet channel, and - an actuation unit for actuating the switch-over body, wherein the actuation unit comprises an operating element disposed on the housing body to be user-operable, characterized in that - the switch-over body comprises an inlet nozzle guided in a fluid-tight manner within the fluid inlet channel for axial and rotational movement, said inlet nozzle constituting the fluid inlet on an inlet side. - a housing body which includes a fluid inlet channel and a plurality of fluid outlet channels arranged fluidically in parallel, - a switch-over body which includes a fluid inlet , at least one fluid outlet and a fluid duct from the fluid inlet to the fluid outlet and is disposed within the housing body to be translationally movable axially parallel and rotationally movable in a combined manner in relation to a longitudinal axis (L) between at least two different operating positions, wherein said switch-over body in each of the different operating positions is in fluid connection to the fluid inlet channel via its fluid inlet and differentially unblocks or blocks at least partially a fluid connection of its fluid outlet to the respective fluid outlet channel, and - an actuation unit for actuating the switch-over body, wherein the actuation unit comprises an operating element disposed on the housing body to be user-operable, characterized in that - the switch-over body comprises an inlet nozzle guided in a fluid-tight manner within the fluid inlet channel for axial and rotational movement, said inlet nozzle constituting the fluid inlet on an inlet side.
A method for determining an analyte suspected to be present in a sample comprising: (a) contacting said sample with a sensor element comprising: (i) an anchor layer which is present on a solid support; (ii) a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer; (iii) a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, said second binding agent comprising at least one magnetic label; and (iv) a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the second binding agent; for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent; and (b) detecting the formation of the complex of first binding agent, analyte and second binding agent based on an altered signal which is generated by the magnetic tunnel junction whereby the analyte is determined. (a) contacting said sample with a sensor element comprising: (i) an anchor layer which is present on a solid support; (ii) a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer; (iii) a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, said second binding agent comprising at least one magnetic label; and (iv) a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the second binding agent; for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent; and (i) an anchor layer which is present on a solid support; (ii) a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer; (iii) a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, said second binding agent comprising at least one magnetic label; and (iv) a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the second binding agent; (b) detecting the formation of the complex of first binding agent, analyte and second binding agent based on an altered signal which is generated by the magnetic tunnel junction whereby the analyte is determined.
An apparatus for at least partially environmentally isolating a volume of an aircraft, the apparatus comprising: a barrier curtain configured, in combination with a plurality of walls , to define the volume; a first cable configured to extend along one or more of the plurality of walls , wherein the barrier curtain is supported by the first cable ; and a cable release mechanism configured to be attached to a wall of the one or more of the plurality of walls , wherein the first cable is held in place by the cable release mechanism , and wherein the cable release mechanism is configured to release the first cable , in response to a load that equals or exceeds a predetermined threshold corresponding to a decompression event. a barrier curtain configured, in combination with a plurality of walls , to define the volume; a first cable configured to extend along one or more of the plurality of walls , wherein the barrier curtain is supported by the first cable ; and a cable release mechanism configured to be attached to a wall of the one or more of the plurality of walls , wherein the first cable is held in place by the cable release mechanism , and wherein the cable release mechanism is configured to release the first cable , in response to a load that equals or exceeds a predetermined threshold corresponding to a decompression event.