A biomimetic microfluidic system comprising: a substrate ; a first channel formed in the substrate , the first channel extending from a first input to a first output along a longitudinal direction , and extending along a first transverse direction ; a second channel formed in the substrate , the second channel extending from a second input to a second output along the longitudinal direction , and extending along the first transverse direction , wherein at least a portion of the first and second channels extend substantially parallel along the longitudinal direction ; columns that separate the first channel and the second channel and extend along a second transverse direction ; a series of apertures formed in between the columns proximal to a first portion of the substrate that create a fluid communication path between the first channel and the second channel , wherein each of the series of apertures extends further along the longitudinal direction than along the first transverse direction and the second transverse direction , and is sized to selectively capture a biological source material capable of producing target biological substances; a first source connected to the first input , the first source configured to selectively introduce into the first channel at least one first biological composition at a first channel flow rate; and a second source connected to the second input , the second source configured to selectively introduce into the second channel at least one second biological composition at a second channel flow rate, wherein the first source and the second source are configured to control the first channel flow rate and the second channel flow rate to create a differential in the channels generating physiological shear rates sufficient to induce the biological source material captured to produce the target biological substances. a substrate ; a first channel formed in the substrate , the first channel extending from a first input to a first output along a longitudinal direction , and extending along a first transverse direction ; a second channel formed in the substrate , the second channel extending from a second input to a second output along the longitudinal direction , and extending along the first transverse direction , wherein at least a portion of the first and second channels extend substantially parallel along the longitudinal direction ; columns that separate the first channel and the second channel and extend along a second transverse direction ; a series of apertures formed in between the columns proximal to a first portion of the substrate that create a fluid communication path between the first channel and the second channel , wherein each of the series of apertures extends further along the longitudinal direction than along the first transverse direction and the second transverse direction , and is sized to selectively capture a biological source material capable of producing target biological substances; a first source connected to the first input , the first source configured to selectively introduce into the first channel at least one first biological composition at a first channel flow rate; and a second source connected to the second input , the second source configured to selectively introduce into the second channel at least one second biological composition at a second channel flow rate, wherein the first source and the second source are configured to control the first channel flow rate and the second channel flow rate to create a differential in the channels generating physiological shear rates sufficient to induce the biological source material captured to produce the target biological substances. <EOS>