mhurhangee/patent-ind-claim-en huggingface dataset:
An apparatus for treatment planning and/or for treatment setup, comprising: a simulator configured to obtain a first model representing a first component of a medical system, and virtually move the first model to simulate a movement of the first component of the medical system; an analyzer configured to determine imaging waypoints based on the virtual movement of the first model; and a graphic generator configured to generate a graphic based on the determined imaging waypoints; wherein the simulator is also configured to obtain a second model representing a patient support , and virtually move the second model to simulate a movement of the patient support ; wherein the simulator is also configured to obtain a surface model of a patient , and virtually move the surface model to simulate a movement of the patient due to a movement of a patient support ; wherein the analyzer comprises a collision analyzer; and wherein said apparatus further comprises an input for receiving a user-defined amount of imaging coverage, wherein the analyzer is configured to determine the imaging waypoints based on the user-defined amount of imaging coverage. a simulator configured to obtain a first model representing a first component of a medical system, and virtually move the first model to simulate a movement of the first component of the medical system; an analyzer configured to determine imaging waypoints based on the virtual movement of the first model; and a graphic generator configured to generate a graphic based on the determined imaging waypoints; wherein the simulator is also configured to obtain a second model representing a patient support , and virtually move the second model to simulate a movement of the patient support ; wherein the simulator is also configured to obtain a surface model of a patient , and virtually move the surface model to simulate a movement of the patient due to a movement of a patient support ; wherein the analyzer comprises a collision analyzer; and wherein said apparatus further comprises an input for receiving a user-defined amount of imaging coverage, wherein the analyzer is configured to determine the imaging waypoints based on the user-defined amount of imaging coverage.
An anti-Trop-2 antibody-drug conjugate (ADC) comprising SN-38 conjugated to an anti-Trop-2 antibody, for use in a method of treating small cell lung cancer (SCLC), wherein the method comprises administering to a human patient with SCLC (i) the anti-Trop-2 antibody-drug conjugate (ADC) and (ii) cisplatin or carboplatin, wherein the ADC is administered as a second-line or later therapy to patients who have received previous cancer treatment for the SCLC, wherein the anti-Trop-2 antibody is a humanized RS7 antibody comprising the light chain CDR sequences CDR1 (KASQDVSIAVA, SEQ ID NO:1); CDR2 (SASYRYT, SEQ ID NO:2); and CDR3 (QQHYITPLT, SEQ ID NO:3) and the heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO:4); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO:5) and CDR3 (GGFGSSYWYFDV, SEQ ID NO:6), and wherein there is a CL2A linker between the SN-38 and the antibody and the structure of the ADC is MAb-CL2A-SN-38
A deep brain stimulation apparatus based on surface-enhanced Raman spectroscopy, the deep brain stimulation apparatus comprising: a stimulator configured to apply electrical stimulation to a brain; characterised by further comprising: a light source configured to emit light to the brain; plasmonic nano-particles configured to allow surface-enhanced Raman scattering, SERS, by contacting a neurotransmitter when the brain secretes the neurotransmitter as a result of the electrical stimulation; a photodetector configured to, when the light incident from the light source is scattered by the neurotransmitter in contact with the plasmonic nano-particles, detect scattered light through an optical fiber; a signal processing analyzer configured to convert a light signal from the photodetector into an electric signal; and a controller configured to receive an analysis signal of the signal processing analyzer to control the stimulator, wherein the plasmonic nano-particles are bonded to a surface of the optical fiber and inserted into a body together with the optical fiber. a light source configured to emit light to the brain; plasmonic nano-particles configured to allow surface-enhanced Raman scattering, SERS, by contacting a neurotransmitter when the brain secretes the neurotransmitter as a result of the electrical stimulation; a photodetector configured to, when the light incident from the light source is scattered by the neurotransmitter in contact with the plasmonic nano-particles, detect scattered light through an optical fiber; a signal processing analyzer configured to convert a light signal from the photodetector into an electric signal; and a controller configured to receive an analysis signal of the signal processing analyzer to control the stimulator, wherein the plasmonic nano-particles are bonded to a surface of the optical fiber and inserted into a body together with the optical fiber.
A method of handling session initiation protocol, SIP, session initiation requests in an IP Multimedia Subsystem, IMS, network, the method comprising, at an application server within the network: receiving (S101) a session initiation request containing a destination address, where that destination address is currently associated with a plurality of user equipments, UE, registered under the destination address in a Serving Call Session Control Function, S-CSCF, in the IMS network; recording an identity of a user equipment, UE, handling a first session in a database during establishment of the first session in respect of the destination address; determining (S102) whether or not a UE, associated with the destination address, is already involved in a session by looking up in a database the address associated with UEs handling ongoing sessions and the identity of the UE handling the first session during establishment of the first session in respect of the destination address, and, if so, then causing (S103) the session initiation request to be forwarded only to that UE and, if not, then causing (S104) the session initiation request to be forwarded to all UEs registered in respect of the address. receiving (S101) a session initiation request containing a destination address, where that destination address is currently associated with a plurality of user equipments, UE, registered under the destination address in a Serving Call Session Control Function, S-CSCF, in the IMS network; recording an identity of a user equipment, UE, handling a first session in a database during establishment of the first session in respect of the destination address; determining (S102) whether or not a UE, associated with the destination address, is already involved in a session by looking up in a database the address associated with UEs handling ongoing sessions and the identity of the UE handling the first session during establishment of the first session in respect of the destination address, and, if so, then causing (S103) the session initiation request to be forwarded only to that UE and, if not, then causing (S104) the session initiation request to be forwarded to all UEs registered in respect of the address. if so, then causing (S103) the session initiation request to be forwarded only to that UE and, if not, then causing (S104) the session initiation request to be forwarded to all UEs registered in respect of the address.
A laundry liquid composition comprising at least 50 % wt. water, an alkyl ether sulphate surfactant and an alcohol ethoxylate surfactant, wherein at least one of the alkyl ether sulphate and alcohol ethoxylate comprises at least 10% weight C16/18 alkyl chains and a dye, wherein the total amount of dye is from 0.00001 to 0.1 wt.%.
An apparatus for continuously processing a slurry comprising a housing enclosing: a slurry feed and solvent wash assembly ; a removable, rotatable porous filter plate , said filter plate configured for receiving a slurry from said slurry feed and solvent wash assembly on its top surface; a rotatable filter support plate supporting said porous filter plate and in fluid communication with a bottom vacuum plate ; a filter support plate rotator for rotating said rotatable filter support plate ; a filtrate outlet in fluid communication with the bottom surface of said filter plate , said rotatable filter support plate , and said bottom vacuum plate , wherein said filtrate outlet is adapted to convey a filtrate out of said housing; a filter cake outlet located at the center of said porous filter plate and adapted to convey a solid filter cake out of said housing; and an auger subassembly comprising an auger enclosed in an auger housing , and a scraper attached to said auger housing , wherein said auger housing is located in proximity to said filter plate , and wherein said auger and said scraper are configured to remove said solid filter cake from said top surface of said filter plate and to convey said solid filter cake to said filter cake outlet when said rotatable filter support plate rotates. a slurry feed and solvent wash assembly ; a removable, rotatable porous filter plate , said filter plate configured for receiving a slurry from said slurry feed and solvent wash assembly on its top surface; a rotatable filter support plate supporting said porous filter plate and in fluid communication with a bottom vacuum plate ; a filter support plate rotator for rotating said rotatable filter support plate ; a filtrate outlet in fluid communication with the bottom surface of said filter plate , said rotatable filter support plate , and said bottom vacuum plate , wherein said filtrate outlet is adapted to convey a filtrate out of said housing; a filter cake outlet located at the center of said porous filter plate and adapted to convey a solid filter cake out of said housing; and an auger subassembly comprising an auger enclosed in an auger housing , and a scraper attached to said auger housing , wherein said auger housing is located in proximity to said filter plate , and wherein said auger and said scraper are configured to remove said solid filter cake from said top surface of said filter plate and to convey said solid filter cake to said filter cake outlet when said rotatable filter support plate rotates.
A method of generating a compound of Formula I wherein one of R 1 , R 2 , R 3 , or R 4 is -X, and the remainder are -H, wherein X is a halogen selected from Cl, Br, or I; comprising: reacting a compound of Formula I with a halogenating reagent in the presence of a first solvent to form the compound of Formula I wherein one of R 5 , R 6 , R 7 , or R 8 is and the remainder are -H; and each of R A and R B are independently -C 1-4 alkyl, -C 3-6 cycloalkyl; or R A and R B together with the oxygen atoms to which they are attached form a 5-6 membered ring optionally substituted with 1-4 of -C 1-3 alkyl, -C 1-3 alkoxycarbonyl, -C 1-3 alkylaminocarbonyl, or any combination thereof; or R A and R B together with the oxygen atoms to which they are attached form a 7-10 membered bicyclic or tricyclic ring optionally substituted with 1-4 of -C 1-3 alkyl, -C 1-3 alkoxycarbonyl, -C 1-3 alkylaminocarbonyl, or any combination thereof. reacting a compound of Formula I with a halogenating reagent in the presence of a first solvent to form the compound of Formula I wherein one of R 5 , R 6 , R 7 , or R 8 is and the remainder are -H; and each of R A and R B are independently -C 1-4 alkyl, -C 3-6 cycloalkyl; or R A and R B together with the oxygen atoms to which they are attached form a 5-6 membered ring optionally substituted with 1-4 of -C 1-3 alkyl, -C 1-3 alkoxycarbonyl, -C 1-3 alkylaminocarbonyl, or any combination thereof; or R A and R B together with the oxygen atoms to which they are attached form a 7-10 membered bicyclic or tricyclic ring optionally substituted with 1-4 of -C 1-3 alkyl, -C 1-3 alkoxycarbonyl, -C 1-3 alkylaminocarbonyl, or any combination thereof.
A method for producing a thymocyte supernatant comprising the following steps: - co-cultivating thymocytes and macrophages at a cell ratio of 0.5:1.2 to 0.5:2 in the presence of phorbol-12-myristate-13-acetate and phytohemagglutinin M for up to 60 hours, and - separating the co-cultivation medium from the cells and thereby producing the thymocyte supernatant. - co-cultivating thymocytes and macrophages at a cell ratio of 0.5:1.2 to 0.5:2 in the presence of phorbol-12-myristate-13-acetate and phytohemagglutinin M for up to 60 hours, and - separating the co-cultivation medium from the cells and thereby producing the thymocyte supernatant.
A method of controlling uplink transmissions from a radio device (10; 700; 1000) to a wireless communication network, the method comprising: the radio device (10; 700; 1000) performing uplink transmissions on a first carrier, the uplink transmissions on the first carrier requiring scheduling by a node (100; 900; 1100) of the wireless communication network; the radio device (10; 700; 1000) performing uplink transmissions on a second carrier, the uplink transmissions on the second carrier requiring that, by a carrier sense operation, the radio device (10; 700; 1000) assesses the second carrier as being unoccupied before proceeding to the uplink transmission on the second carrier; the radio device (10; 700; 1000) performing the carrier sense operation to assess whether the second carrier is unoccupied; and the radio device (10; 700; 1000) providing an indication of a result of the carrier sense operation to the node (100; 900; 1100) by: - transmitting on the first carrier on the basis of a first transport format if the result of the carrier sense operation is that the second carrier is assessed as being occupied; and - transmitting on the first carrier on the basis of a second transport format if the result of the carrier sense operation is that the second carrier is assessed as being unoccupied. the radio device (10; 700; 1000) performing uplink transmissions on a first carrier, the uplink transmissions on the first carrier requiring scheduling by a node (100; 900; 1100) of the wireless communication network; the radio device (10; 700; 1000) performing uplink transmissions on a second carrier, the uplink transmissions on the second carrier requiring that, by a carrier sense operation, the radio device (10; 700; 1000) assesses the second carrier as being unoccupied before proceeding to the uplink transmission on the second carrier; the radio device (10; 700; 1000) performing the carrier sense operation to assess whether the second carrier is unoccupied; and the radio device (10; 700; 1000) providing an indication of a result of the carrier sense operation to the node (100; 900; 1100) by: - transmitting on the first carrier on the basis of a first transport format if the result of the carrier sense operation is that the second carrier is assessed as being occupied; and - transmitting on the first carrier on the basis of a second transport format if the result of the carrier sense operation is that the second carrier is assessed as being unoccupied. - transmitting on the first carrier on the basis of a first transport format if the result of the carrier sense operation is that the second carrier is assessed as being occupied; and - transmitting on the first carrier on the basis of a second transport format if the result of the carrier sense operation is that the second carrier is assessed as being unoccupied.
A last for forming a shoe upper, the last comprising: a plurality of last forming parts, wherein in a forming surface (S) for forming the shoe upper, at least a portion of a specific region corresponding to an upper end portion of a to-be-formed portion of the shoe upper is defined by a plurality of plate-shaped parts included in the last forming parts, by arranging the plate-shaped parts to be spaced apart from each other in a circumferential direction of an upper end portion of the shoe upper, a portion of the specific region that is defined by the plate-shaped parts is defined by an end surface of each of the plate-shaped parts , and recessed portions as a mark used for alignment with the last during overlaying of the shoe upper are in the portion of the specific region that is defined by the plate-shaped parts , wherein the recessed portions are provided entirely in a loop shape. a plurality of last forming parts, wherein in a forming surface (S) for forming the shoe upper, at least a portion of a specific region corresponding to an upper end portion of a to-be-formed portion of the shoe upper is defined by a plurality of plate-shaped parts included in the last forming parts, by arranging the plate-shaped parts to be spaced apart from each other in a circumferential direction of an upper end portion of the shoe upper, a portion of the specific region that is defined by the plate-shaped parts is defined by an end surface of each of the plate-shaped parts , and recessed portions as a mark used for alignment with the last during overlaying of the shoe upper are in the portion of the specific region that is defined by the plate-shaped parts , wherein the recessed portions are provided entirely in a loop shape.
A method of washing particles in an acoustic chamber , the method comprising: a) flowing a suspension of particles in a suspension medium through a standing wave generated in a standing wave volume of the acoustic chamber to accumulate within the acoustic chamber at least some of the particles as raw particle concentrate; and b) flowing a wash medium through the acoustic chamber to wash within the acoustic chamber at least some of the particles of the raw particle concentrate, and retaining within the acoustic chamber at least some washed particles; wherein some particles of the raw particle concentrate settle within a settling volume of the acoustic chamber , and wherein some of the washed particles settle within the settling volume , the settling volume located below the standing wave volume ; characterized in that the acoustic chamber includes a first bottom port below the settling volume , a top port above the standing wave volume , and a side port above the settling volume , and wherein during step (b), the wash medium flows through the acoustic chamber from the first bottom port to the top port through the raw particle concentrate, and wherein the method further comprises at least one of: i) during step a) flowing the suspension medium through the acoustic chamber from the side port to the top port through the standing wave; ii) after step (a) and prior to step (b), evacuating at least some supernatant suspension medium from the acoustic chamber , and replacing the evacuated supernatant suspension medium with the wash medium, wherein the supernatant suspension medium is evacuated from the acoustic chamber through the side port and/or wherein the wash medium flows into the acoustic chamber through the side port to replace the evacuated suspension medium. a) flowing a suspension of particles in a suspension medium through a standing wave generated in a standing wave volume of the acoustic chamber to accumulate within the acoustic chamber at least some of the particles as raw particle concentrate; and b) flowing a wash medium through the acoustic chamber to wash within the acoustic chamber at least some of the particles of the raw particle concentrate, and retaining within the acoustic chamber at least some washed particles; i) during step a) flowing the suspension medium through the acoustic chamber from the side port to the top port through the standing wave; ii) after step (a) and prior to step (b), evacuating at least some supernatant suspension medium from the acoustic chamber , and replacing the evacuated supernatant suspension medium with the wash medium, wherein the supernatant suspension medium is evacuated from the acoustic chamber through the side port and/or wherein the wash medium flows into the acoustic chamber through the side port to replace the evacuated suspension medium.
A self-cleaning electrochemical cell comprising: a plurality of electrodes disposed concentrically in a housing about a central axis of the housing; a fluid channel defined between adjacent electrodes of the plurality of electrodes and extending substantially parallel to the central axis; and an electrical connector positioned at a distal end of at least one of the plurality of electrodes and electrically connected to the at least one of the plurality of electrodes, the electrical connector comprising corresponding concentric wheels and a plurality of spokes extending between adjacent wheels to provide electrical connection between each concentric wheel, each concentric wheel being further configured to provide electrical connection to a corresponding electrode tube, the height (H) of the spoke being dimensioned to correspond to the gap between concentric wheels, the length (L) of the spoke being dimensioned to minimize electrical resistance and heat generation while maintaining a desired power dissipation, the width (W) of the spokes being between 0.25 and 2 times the height of the spokes to allow fluid flow through the fluid channel and provide a substantially even current distribution to the at least one of the plurality of electrodes while maintaining a zone of reduced velocity having less than a predetermined length within the fluid channel downstream of the electrical connector, the zone of reduced velocity defined by a region in the fluid channel in which fluid flow velocity deviates from a mean fluid flow velocity in the channel by within 20%. a plurality of electrodes disposed concentrically in a housing about a central axis of the housing; a fluid channel defined between adjacent electrodes of the plurality of electrodes and extending substantially parallel to the central axis; and an electrical connector positioned at a distal end of at least one of the plurality of electrodes and electrically connected to the at least one of the plurality of electrodes, the electrical connector comprising corresponding concentric wheels and a plurality of spokes extending between adjacent wheels to provide electrical connection between each concentric wheel, each concentric wheel being further configured to provide electrical connection to a corresponding electrode tube, the height (H) of the spoke being dimensioned to correspond to the gap between concentric wheels, the length (L) of the spoke being dimensioned to minimize electrical resistance and heat generation while maintaining a desired power dissipation, the width (W) of the spokes being between 0.25 and 2 times the height of the spokes to allow fluid flow through the fluid channel and provide a substantially even current distribution to the at least one of the plurality of electrodes while maintaining a zone of reduced velocity having less than a predetermined length within the fluid channel downstream of the electrical connector, the zone of reduced velocity defined by a region in the fluid channel in which fluid flow velocity deviates from a mean fluid flow velocity in the channel by within 20%.