A compound according to Formula (I): or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof, wherein: is , or ; Z is S(O), S(O) 2 or S(O)NR 4 , R 1 is OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 2 is H, (C 1 -C 8 )alkyl or halogen; R 3 groups each independently are H, halogen, CN, OR 5 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, NHR 5 , NR 5 R 5 , [(C 1 -C 8 )alkylene]NHR 5 , [(C 1 -C 8 )alkylene]NR 5 R 5 , N(C 1 -C 8 )alkyl[(C 1 -C 8 )alkylene]NHR 5 , N(C 1 -C 8 )alkyl[(C 1 -C 8 )alkylene]NR 5 R 5 , C(O)NHR 5 , C(O)NR 5 R 5 , SO 2 NHR 5 , SO 2 NR 5 R 5 , S(O)R 5 , SO 2 R 5 , NR 5 C(O)R 5 , NR 5 SO 2 R 5 , cycloalkyl, heterocyclyl, aryl or heteroaryl; R 4 is H, CN, CO 2 (C 1 -C 8 )alkyl, CO 2 cycloalkyl, CO 2 heterocyclyl, CO 2 aryl, CO 2 heteroaryl, CO 2 [(C 1 -C 8 )alkylene]cycloalkyl, CO 2 [(C 1 -C 8 )alkylene]heterocyclyl, CO 2 [(C 1 -C 8 )alkylene]aryl or CO 2 [(C 1 -C 8 )alkylene]heteroaryl; R 5 is H, (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8 )alkylene]cycloalkyl, [(C 1 -C 8 )alkylene]heterocyclyl, [(C 1 -C 8 )alkylene]aryl or [(C 1 -C 8 )alkylene]heteroaryl, or R 5 and R 5 taken together with the nitrogen atom to which they are attached form a heterocyclyl; Ar is wherein R 6 is H, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8 )alkylene]cycloalkyl or [(C 1 -C 8 )alkylene]heterocyclyl; and wherein any alkyl, alkenyl, alkynyl, haloalkyl, alkylene, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1, 2 or 3 groups selected from OH, CN, NH 2 , NO 2 , halogen, cycloalkyl, -(C 1 -C 3 alkylene)NH 2 and -(C 1 -C 3 alkylene)N(C 1 -C 3 alkyl) 2 . Z is S(O), S(O) 2 or S(O)NR 4 , R 1 is OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R 2 is H, (C 1 -C 8 )alkyl or halogen; R 3 groups each independently are H, halogen, CN, OR 5 , (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, NHR 5 , NR 5 R 5 , [(C 1 -C 8 )alkylene]NHR 5 , [(C 1 -C 8 )alkylene]NR 5 R 5 , N(C 1 -C 8 )alkyl[(C 1 -C 8 )alkylene]NHR 5 , N(C 1 -C 8 )alkyl[(C 1 -C 8 )alkylene]NR 5 R 5 , C(O)NHR 5 , C(O)NR 5 R 5 , SO 2 NHR 5 , SO 2 NR 5 R 5 , S(O)R 5 , SO 2 R 5 , NR 5 C(O)R 5 , NR 5 SO 2 R 5 , cycloalkyl, heterocyclyl, aryl or heteroaryl; R 4 is H, CN, CO 2 (C 1 -C 8 )alkyl, CO 2 cycloalkyl, CO 2 heterocyclyl, CO 2 aryl, CO 2 heteroaryl, CO 2 [(C 1 -C 8 )alkylene]cycloalkyl, CO 2 [(C 1 -C 8 )alkylene]heterocyclyl, CO 2 [(C 1 -C 8 )alkylene]aryl or CO 2 [(C 1 -C 8 )alkylene]heteroaryl; R 5 is H, (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8 )alkylene]cycloalkyl, [(C 1 -C 8 )alkylene]heterocyclyl, [(C 1 -C 8 )alkylene]aryl or [(C 1 -C 8 )alkylene]heteroaryl, or R 5 and R 5 taken together with the nitrogen atom to which they are attached form a heterocyclyl; Ar is wherein R 6 is H, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, [(C 1 -C 8 )alkylene]cycloalkyl or [(C 1 -C 8 )alkylene]heterocyclyl; and wherein any alkyl, alkenyl, alkynyl, haloalkyl, alkylene, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally substituted with 1, 2 or 3 groups selected from OH, CN, NH 2 , NO 2 , halogen, cycloalkyl, -(C 1 -C 3 alkylene)NH 2 and -(C 1 -C 3 alkylene)N(C 1 -C 3 alkyl) 2 . <EOS>