mhurhangee/patent-ind-claim-en huggingface dataset:
A system for insertion of a donor nucleic acid into genomic DNA, comprising: (a) a fusion protein comprising: i) a first protein comprising a catalytically inactive Cas9 protein; ii) a second protein comprising a retroviral integrase, and iii) a linker linking the first protein to the second protein; (b) a guide RNA (gRNA); and (c) a DNA vector comprising: the donor DNA, a first retroviral long terminal repeat (rLTR) and a second rLTR, wherein the donor DNA is located between the first rLTR and second rLTR. (a) a fusion protein comprising: i) a first protein comprising a catalytically inactive Cas9 protein; ii) a second protein comprising a retroviral integrase, and iii) a linker linking the first protein to the second protein; i) a first protein comprising a catalytically inactive Cas9 protein; ii) a second protein comprising a retroviral integrase, and iii) a linker linking the first protein to the second protein; (b) a guide RNA (gRNA); and (c) a DNA vector comprising: the donor DNA, a first retroviral long terminal repeat (rLTR) and a second rLTR, wherein the donor DNA is located between the first rLTR and second rLTR.
An aircraft radome comprising: - a composite structure defining at least one housing located inside or outside the composite structure and extending along the radome from a base of said radome, said at least one housing receiving an electrically conductive strip and said conductive strip being either in contact with an inner surface of an external wall of the composite structure when said at least one housing is inside the composite structure , or flush with the external wall of the composite structure when said at least one housing is outside the composite structure , - a conductive base located at the level of said radome base and connected to a ground of the aircraft, characterized in that said composite structure being devoid of any perforations or passages through the external wall at the electrically conductive strip and in that a first end of said electrically conductive strip being in contact with the conductive base . - a composite structure defining at least one housing located inside or outside the composite structure and extending along the radome from a base of said radome, said at least one housing receiving an electrically conductive strip and said conductive strip being either in contact with an inner surface of an external wall of the composite structure when said at least one housing is inside the composite structure , or flush with the external wall of the composite structure when said at least one housing is outside the composite structure , - a conductive base located at the level of said radome base and connected to a ground of the aircraft,
Formwork core for a formwork system for casting a bell-shaped body, comprising a base, vertical corner supports and side formwork elements, which are rotatably mounted at the corner supports in such a manner that the side formwork elements can be retracted inwards, wherein the corner supports each carry two corner connection panels , which are arranged perpendicular to each other around the corner and are synchronously retractable and extendable without touching, wherein, in the fully extended state, a narrow vertical gap remains between the two corner connection panels in the area of the corner; the corner supports each carry a corner bracket , which are synchronously retractable and extendable and, in the fully extended state, close the gap between the two corresponding corner connection panels to form a vertical outer edge of the formwork core ; the vertical edges of the corner connection panels remote from the corner can be releasably attached to one another, characterized in that two corner supports each are releasably attached to a common base frame in variable distance.
A cardiac device for delivering a cardiac remodeling pacing to a patient, comprising: a housing ; a plurality of electrodes electrically connected to the housing to deliver the cardiac remodeling pacing to dilate the LV chamber of the patient's heart over time to stimulate normalization of a condition of the patient's heart; and a processor positioned within the housing and configured to: monitor one or more parameters in response to the delivered cardiac remodeling pacing, determine, in response to the monitoring, whether the cardiac remodeling pacing has an effect on cardiac normalization, and adjust, in response to the determined effect on cardiac normalization, the cardiac remodeling pacing. a housing ; a plurality of electrodes electrically connected to the housing to deliver the cardiac remodeling pacing to dilate the LV chamber of the patient's heart over time to stimulate normalization of a condition of the patient's heart; and a processor positioned within the housing and configured to: monitor one or more parameters in response to the delivered cardiac remodeling pacing, determine, in response to the monitoring, whether the cardiac remodeling pacing has an effect on cardiac normalization, and adjust, in response to the determined effect on cardiac normalization, the cardiac remodeling pacing. monitor one or more parameters in response to the delivered cardiac remodeling pacing, determine, in response to the monitoring, whether the cardiac remodeling pacing has an effect on cardiac normalization, and adjust, in response to the determined effect on cardiac normalization, the cardiac remodeling pacing.
Antenna device for use in a communication system of a timepiece, said device being characterised in that it includes: - a substrate in the form of a first plate with an arcuate profile; - a first antenna circuit formed on said substrate and having first and second strands with a proximal end and a distal end, and extending in parallel between their proximal and distal ends, the first and second strands being connected at their proximal ends and separated at their distal ends; - a second antenna circuit formed on said substrate and having third and fourth strands with a proximal end and a distal end, and extending in parallel between their proximal and distal ends, the third and fourth strands being connected at their distal ends and separated at their proximal ends; - an electrical junction link joining the proximal ends of the first and third strands; - a connection part configured to be bent relative to the first plate, about an axis perpendicular to the axis (X) and parallel to the plane (P), and including a conductive connection connected to the electrical junction link and including an electromagnetic shield for said conductive connection. - a substrate in the form of a first plate with an arcuate profile; - a first antenna circuit formed on said substrate and having first and second strands with a proximal end and a distal end, and extending in parallel between their proximal and distal ends, the first and second strands being connected at their proximal ends and separated at their distal ends; - a second antenna circuit formed on said substrate and having third and fourth strands with a proximal end and a distal end, and extending in parallel between their proximal and distal ends, the third and fourth strands being connected at their distal ends and separated at their proximal ends; - an electrical junction link joining the proximal ends of the first and third strands; - a connection part configured to be bent relative to the first plate, about an axis perpendicular to the axis (X) and parallel to the plane (P), and including a conductive connection connected to the electrical junction link and including an electromagnetic shield for said conductive connection.
Female part of an animal-identifying device, comprising a cavity intended to receive a head of a male part of said animal-identifying device, said cavity comprising a blocking element provided within said cavity, intended to hold said head inside said cavity, said blocking element comprising a base and at least two resilient claws extending from said base towards the entrance of said cavity, characterized in that said claws are movable between at least two positions, one position before insertion of the head into the cavity, called insertion position, in which said claws are stressed into opening and enable the insertion of said head into said cavity, and one position after insertion of the head into the cavity, called blocking position, enabling the blocking of said head inside said cavity.
A rocker arm for a valve train assembly , the rocker arm comprising: a first body ; a second body mounted for pivotal movement with respect to the first body ; and a latching arrangement comprising a latch pin drivable in response to an external actuator (F) from a first position in which the first body and the second body are un-latched to a second position in which the latch pin latches the first body and the second body together; wherein the latching arrangement further comprises a piston member and a first biasing member and wherein the piston member is arranged so that if the external actuator (F) attempts to cause the latch pin to be driven from the first position to the second position at a time when the latch pin is prevented from being driven, the piston member moves to bias the first biasing member so that the first biasing member urges the latch pin to the second position when the latch pin again becomes driveable, wherein one of the first body and second body comprises a bore or channel and wherein the latch pin is at least partially mounted within the bore or channel and characterised in that the first biasing member and the piston member are at least partially mounted within the bore or channel . a first body ; a second body mounted for pivotal movement with respect to the first body ; and a latching arrangement comprising a latch pin drivable in response to an external actuator (F) from a first position in which the first body and the second body are un-latched to a second position in which the latch pin latches the first body and the second body together; wherein the latching arrangement further comprises a piston member and a first biasing member and wherein the piston member is arranged so that if the external actuator (F) attempts to cause the latch pin to be driven from the first position to the second position at a time when the latch pin is prevented from being driven, the piston member moves to bias the first biasing member so that the first biasing member urges the latch pin to the second position when the latch pin again becomes driveable, wherein one of the first body and second body comprises a bore or channel and wherein the latch pin is at least partially mounted within the bore or channel and characterised in that the first biasing member and the piston member are at least partially mounted within the bore or channel .
A system comprising: a single power supply , the single power supply includes a power converter coupled to an output , to provide an output power to a main load and an auxiliary power to an auxiliary load , and a single switch positioned between the output and the main load ; a controller configured to: interrupt the output power through the switch based on a determination that the output power is below an output threshold ; wherein interruption of the output power through the switch is by disconnecting the output through the switch ; and interrupt the auxiliary power , coupled to the output , based on a determination the auxiliary power is below an auxiliary threshold ; wherein interruption of the auxiliary power is by powering down the single power supply . a single power supply , the single power supply includes a power converter coupled to an output , to provide an output power to a main load and an auxiliary power to an auxiliary load , and a single switch positioned between the output and the main load ; a controller configured to: interrupt the output power through the switch based on a determination that the output power is below an output threshold ; wherein interruption of the output power through the switch is by disconnecting the output through the switch ; and interrupt the auxiliary power , coupled to the output , based on a determination the auxiliary power is below an auxiliary threshold ; wherein interruption of the auxiliary power is by powering down the single power supply . interrupt the output power through the switch based on a determination that the output power is below an output threshold ; wherein interruption of the output power through the switch is by disconnecting the output through the switch ; and interrupt the auxiliary power , coupled to the output , based on a determination the auxiliary power is below an auxiliary threshold ; wherein interruption of the auxiliary power is by powering down the single power supply .
A hand guided, walk-behind floor treatment machine comprising: a base portion provided with and supported by at least one rotatable work head for treating the floor, drive means for rotating the work head with respect to the base portion, guide wheel means for supporting the handle portion and/or base portion on the floor, the guide wheel means having a substantially transverse axis of rotation with respect to the base portion so as to permit machine travel over the floor in a working direction, a handle portion for steering or guiding the machine in the working direction of travel, a lower region of which handle portion is provided with an articulated joint arrangement which permits pivoting of the handle portion with respect to the base portion during machine operation, the handle portion lower region being connected to the guide wheel means or base portion so as to permit steering by manipulation of an upper region of the handle, wherein a motor traction drive is provided for driving the guide wheel means so as to permit self-propulsion of the machine over the floor and a motor controller is provided for controlling the operation of the motor traction drive, wherein the articulated joint arrangement is adapted to permit fore/aft and side to side pivoting of the handle portion with respect to the base portion and wherein the joint arrangement also permits the transfer of steering torque applied by a user to the upper handle portion to the guide wheel means or base portion, thereby to permit yaw steering of the guide wheel means left or right. a base portion provided with and supported by at least one rotatable work head for treating the floor, drive means for rotating the work head with respect to the base portion, guide wheel means for supporting the handle portion and/or base portion on the floor, the guide wheel means having a substantially transverse axis of rotation with respect to the base portion so as to permit machine travel over the floor in a working direction, a handle portion for steering or guiding the machine in the working direction of travel, a lower region of which handle portion is provided with an articulated joint arrangement which permits pivoting of the handle portion with respect to the base portion during machine operation, the handle portion lower region being connected to the guide wheel means or base portion so as to permit steering by manipulation of an upper region of the handle, wherein a motor traction drive is provided for driving the guide wheel means so as to permit self-propulsion of the machine over the floor and a motor controller is provided for controlling the operation of the motor traction drive, wherein the articulated joint arrangement is adapted to permit fore/aft and side to side pivoting of the handle portion with respect to the base portion and wherein the joint arrangement also permits the transfer of steering torque applied by a user to the upper handle portion to the guide wheel means or base portion, thereby to permit yaw steering of the guide wheel means left or right.
A method of validating software of a device , the method comprising: extracting, by the device, a public key from a secure data storage area of the device; extracting, by the device, a first certificate for a public intermediate key and a second certificate for a public signing key, the first certificate and the second certificate being extracted from a system image that is for a particular product, the system image comprising (i) multiple software modules, (ii) a data set including module signatures for the multiple software modules, and (iii) a system image signature generated using a private key for the particular product, the system image signature being based on the data set including the module signatures for the multiple software modules; verifying, by the device, a signature of the first certificate using the public key; after verifying the signature of the first certificate, verifying, by the device, the second certificate using the public intermediate key in the first certificate; and in response to verifying the second certificate, loading, by the device, the system image during a boot process of the device. extracting, by the device, a public key from a secure data storage area of the device; extracting, by the device, a first certificate for a public intermediate key and a second certificate for a public signing key, the first certificate and the second certificate being extracted from a system image that is for a particular product, the system image comprising (i) multiple software modules, (ii) a data set including module signatures for the multiple software modules, and (iii) a system image signature generated using a private key for the particular product, the system image signature being based on the data set including the module signatures for the multiple software modules; verifying, by the device, a signature of the first certificate using the public key; after verifying the signature of the first certificate, verifying, by the device, the second certificate using the public intermediate key in the first certificate; and in response to verifying the second certificate, loading, by the device, the system image during a boot process of the device.
A method of identifying nucleic acid regions within a nucleic acid sample which interact with one another, the method comprising the steps: A. fragmenting a 3C library which was produced from the nucleic acid sample to produce nucleic acid fragments; B. optionally, adding sequencing adaptors to the ends of the nucleic acid fragments and/or amplifying the nucleic acid fragments; C. contacting the nucleic acid fragments with a targeting nucleic acid which binds to a subgroup of the nucleic acid fragments, wherein the targeting nucleic acid is labelled with the first half of a binding pair; D. isolating the subgroup of nucleic acid fragments which have been bound by the targeting nucleic acid using the second half of the binding pair; E. amplifying the isolated subgroup of nucleic acid fragments; F. repeating Steps C, D and E in this order; and G. optionally sequencing the amplified isolated subgroup of nucleic acid fragments. A. fragmenting a 3C library which was produced from the nucleic acid sample to produce nucleic acid fragments; B. optionally, adding sequencing adaptors to the ends of the nucleic acid fragments and/or amplifying the nucleic acid fragments; C. contacting the nucleic acid fragments with a targeting nucleic acid which binds to a subgroup of the nucleic acid fragments, wherein the targeting nucleic acid is labelled with the first half of a binding pair; D. isolating the subgroup of nucleic acid fragments which have been bound by the targeting nucleic acid using the second half of the binding pair; E. amplifying the isolated subgroup of nucleic acid fragments; F. repeating Steps C, D and E in this order; and G. optionally sequencing the amplified isolated subgroup of nucleic acid fragments.
An injection device comprising: a plunger for expressing medicament from a syringe; a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe; a latch arrangement arranged to releasably hold the plunger against the force of the delivery mechanism, the latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position; and a trigger for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger; and wherein the plunger comprises: a reduced cross section neck configured to be received in the aperture of the latch and a head earwardly of the neck to retain the plunger when the latch is in its non-deflected position; characterised in that a forward facing transition surface extends from the neck to the head, the transition surface having an asymmetric profile about the longitudinal axis of the plunger. a plunger for expressing medicament from a syringe; a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe; a latch arrangement arranged to releasably hold the plunger against the force of the delivery mechanism, the latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position; and a trigger for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger; and wherein the plunger comprises: a reduced cross section neck configured to be received in the aperture of the latch and a head earwardly of the neck to retain the plunger when the latch is in its non-deflected position; characterised in that a forward facing transition surface extends from the neck to the head, the transition surface having an asymmetric profile about the longitudinal axis of the plunger.