A compound of formula I wherein X1 is N or C(R7), R2 and R4 are independently selected from hydrogen or fluoro, R5 is hydrogen or halogen, R6 is selected from halogen, cyano, C 3-5 cycloalkyl, C 3-5 cycloalkylmethoxy, phenyloxy, benzyloxy, benzylmethoxy, pyridinylmethoxy, C 1-3 alkoxy and C 1-3 alkyl, wherein each cycloalkyl, benzyl, pyridinyl, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, cyano, C 1-.2 alkoxy and fluoroC 1-.2 alkoxy, or R6 together with R7 and the C-atoms to which they are attached form a five or six-membered aromatic or non-aromatic ring which may comprise one or two ring forming heteroatoms, wherein said ring is unsubstituted or substituted with one to three residues R13, R7, if present, is selected from hydrogen, halogen, cyclopropyl, cyclopropyloxy, C 1-3 alkoxy, and C 1-3 alkyl, wherein each alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C 1-2 alkoxy, fluoro(C 1-2 )alkoxy and cyano, or R7 forms a ring together with R6 as described above, R8 is selected from hydrogen, halogen, methoxy, ethoxy, fluoromethoxy and fluoroethoxy, R10 is selected from hydrogen, cyano, halogen, C 3-5 cycloalkyl, C 3-5 cycloalkyloxy, C 3-5 cycloalkylmethoxy, C 1-4 alkoxy, and C 1-4 alkyl, wherein each cycloalkyl, cycloalkyloxy, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C 1-3 alkoxy, fluoro(C 1-3 )alkoxy and cyano, R11 is selected from hydrogen, fluoro and methoxy, X2 is N or C(R12), R12 is selected from hydrogen, methoxy and halogen, R13, in each occurrence, is independently selected from halogen, hydroxy, cyano, methyl, methoxy, fluoromethyl and fluoromethoxy, and pharmaceutically acceptable salts, solvates and isotopes thereof. X1 is N or C(R7), R2 and R4 are independently selected from hydrogen or fluoro, R5 is hydrogen or halogen, R6 is selected from halogen, cyano, C 3-5 cycloalkyl, C 3-5 cycloalkylmethoxy, phenyloxy, benzyloxy, benzylmethoxy, pyridinylmethoxy, C 1-3 alkoxy and C 1-3 alkyl, wherein each cycloalkyl, benzyl, pyridinyl, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, cyano, C 1-.2 alkoxy and fluoroC 1-.2 alkoxy, or R6 together with R7 and the C-atoms to which they are attached form a five or six-membered aromatic or non-aromatic ring which may comprise one or two ring forming heteroatoms, wherein said ring is unsubstituted or substituted with one to three residues R13, R7, if present, is selected from hydrogen, halogen, cyclopropyl, cyclopropyloxy, C 1-3 alkoxy, and C 1-3 alkyl, wherein each alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C 1-2 alkoxy, fluoro(C 1-2 )alkoxy and cyano, or R7 forms a ring together with R6 as described above, R8 is selected from hydrogen, halogen, methoxy, ethoxy, fluoromethoxy and fluoroethoxy, R10 is selected from hydrogen, cyano, halogen, C 3-5 cycloalkyl, C 3-5 cycloalkyloxy, C 3-5 cycloalkylmethoxy, C 1-4 alkoxy, and C 1-4 alkyl, wherein each cycloalkyl, cycloalkyloxy, alkyl and alkoxy can be substituted with one or more substituent selected from halogen, C 1-3 alkoxy, fluoro(C 1-3 )alkoxy and cyano, R11 is selected from hydrogen, fluoro and methoxy, X2 is N or C(R12), R12 is selected from hydrogen, methoxy and halogen, R13, in each occurrence, is independently selected from halogen, hydroxy, cyano, methyl, methoxy, fluoromethyl and fluoromethoxy, <EOS>