A cassette for use in parallel electrophoretic assays, the cassette comprising: - a tray, the tray having a floor and two pairs of opposing side walls extending upwards from the floor, the tray at least partially defining a plurality of assay channels, each of the assay channels comprising: - a first buffer reservoir; - a second buffer reservoir; and - a media channel, the media channel extending between, and in fluid communication with, the first and second buffer reservoirs; - a lid, the lid being adapted to engage the side walls of the tray, thereby creating a space between the tray floor and the lid, the lid comprising a plurality of ports, each of the ports extending from an outer surface of the lid to an inner surface of the lid, the plurality of ports comprising: - a plurality of first and second buffer reservoir ports being adapted for introducing and/or removing buffer; - a plurality of sample ports each comprising an enlarged portion to accommodate entry of a pipette tip therewithin and adapted for introducing one or more samples into the media channels, each of the plurality of sample ports comprising one or more tip registration features for guiding the pipette tip to a desired location in the sample port; - at least one port adapted to introduce an electrical current to the cassette; wherein, when the lid is engaged with the tray, the plurality of first and second buffer reservoir ports are in fluid communication with the first and second buffer reservoirs respectively, and the plurality of sample ports are aligned with the plurality of media channels, respectively. - a tray, the tray having a floor and two pairs of opposing side walls extending upwards from the floor, the tray at least partially defining a plurality of assay channels, each of the assay channels comprising: - a first buffer reservoir; - a second buffer reservoir; and - a media channel, the media channel extending between, and in fluid communication with, the first and second buffer reservoirs; - a first buffer reservoir; - a second buffer reservoir; and - a media channel, the media channel extending between, and in fluid communication with, the first and second buffer reservoirs; - a lid, the lid being adapted to engage the side walls of the tray, thereby creating a space between the tray floor and the lid, the lid comprising a plurality of ports, each of the ports extending from an outer surface of the lid to an inner surface of the lid, the plurality of ports comprising: - a plurality of first and second buffer reservoir ports being adapted for introducing and/or removing buffer; - a plurality of sample ports each comprising an enlarged portion to accommodate entry of a pipette tip therewithin and adapted for introducing one or more samples into the media channels, each of the plurality of sample ports comprising one or more tip registration features for guiding the pipette tip to a desired location in the sample port; - at least one port adapted to introduce an electrical current to the cassette; - a plurality of first and second buffer reservoir ports being adapted for introducing and/or removing buffer; - a plurality of sample ports each comprising an enlarged portion to accommodate entry of a pipette tip therewithin and adapted for introducing one or more samples into the media channels, each of the plurality of sample ports comprising one or more tip registration features for guiding the pipette tip to a desired location in the sample port; - at least one port adapted to introduce an electrical current to the cassette; <EOS>