mhurhangee/patent-ind-claim-en huggingface dataset:
An iCP-RF (improved Cell-Permeable Reprogramming factor) recombinant protein, which comprises a RF protein selected from the group consisting of OCT4, SOX2, CMYC, KLF4, NANOG, LIN28 and ZSCAN4, and an advanced macromolecule transduction domain (aMTD) being composed of 9 to 13 amino acid sequences and having improved cell or tissue permeability, wherein the aMTD is fused to one end or both ends of the RF protein and has the following features of: (a) being composed of 3 or more amino acids selected from the group consisting of Ala, Val, Ile, Leu, and Pro; (b) having proline as amino acids corresponding to any one or more of positions 5 to 8, and 12 of its amino acid sequence; and (c) having an instability index of 40 to 60; an aliphatic index of 180 to 220; and a grand average of hydropathy (GRAVY) of 2.1 to 2.6, as measured by Protparam, wherein one or more solubilization domain (SD)(s) are further fused to the end(s) of one or more of the RF protein and the aMTD, wherein the SD(s), independently, have an amino acid sequence selected from the group consisting of SEQ ID NOs: 798 to 804, optionally wherein the SD(s), independently, are encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 805 to 811. (a) being composed of 3 or more amino acids selected from the group consisting of Ala, Val, Ile, Leu, and Pro; (b) having proline as amino acids corresponding to any one or more of positions 5 to 8, and 12 of its amino acid sequence; and (c) having an instability index of 40 to 60; an aliphatic index of 180 to 220; and a grand average of hydropathy (GRAVY) of 2.1 to 2.6, as measured by Protparam,
A forming apparatus comprising: a frame defining a vertical axis , a horizontal axis , and a longitudinal axis ; a carriage movably connected to the frame ; a first stomp foot movably connected to the carriage ; a first end effector movably connected to the carriage , said first end effector controlled by an actuator ; further comprising a second end effector movably connected to the carriage , said second end effector is laterally opposed from said first end effector relative to the longitudinal axis; a second stomp foot movably connected to the carriage , said second stomp foot located between the first stomp foot and the second end effector ; a ply support feature located below the first stomp foot and the second stomp foot ; and wherein the first end effector comprises a first forming feature and the second end effector comprises a second forming feature . a frame defining a vertical axis , a horizontal axis , and a longitudinal axis ; a carriage movably connected to the frame ; a first stomp foot movably connected to the carriage ; a first end effector movably connected to the carriage , said first end effector controlled by an actuator ; further comprising a second end effector movably connected to the carriage , said second end effector is laterally opposed from said first end effector relative to the longitudinal axis; a second stomp foot movably connected to the carriage , said second stomp foot located between the first stomp foot and the second end effector ; a ply support feature located below the first stomp foot and the second stomp foot ; and wherein the first end effector comprises a first forming feature and the second end effector comprises a second forming feature .
A heat generating assembly , comprising a water inlet , a water outlet , and a heat generating body provided between the water inlet and the water outlet , wherein the heat generating body comprises a heating film , a bottom cover for the heating film , and a protective cover for the heating film , the heating film is placed in the protective cover and capable of generating heat upon energization to heat water flowing through the heat generating body ; characterized in that the bottom cover is fixed to a side of the heating film so as to form a liquid channel, an exhaust passage for discharging the air from said water inlet to said water outlet is provided in an upper portion of the bottom cover , and the exhaust passage is provided between the water inlet and the water outlet .
Oxidized Regenerated Cellulose (ORC) and/or Oxidized Cellulose (OC); and doxorubicin for use in a method of treating cancer in a patient, wherein the ORC and/or OC and the doxorubicin are for administration in a non-blended form; said method comprising delivering by a systemic route the doxorubicin and placing the ORC and/or OC in direct connection with or adjacent to the cancerous cells, tissue and/or organ, thereby increasing the sensitivity of the cancerous cells, tissue and/or organ to the doxorubicin.
A cable preparation machine including a cable cutting device comprising: a blade assembly having a plurality of arms and braid blades mounted to the corresponding arms , the arms and the braid blades being disposed about a cable opening configured to receive an end of a cable therein along a cable axis ; the arms being movable relative to each other between retracted positions and advanced positions, the arms being arranged to move the braid blades closer to each other within the cable opening as the arms are moved from the retracted positions to the advanced positions; the braid blades having edges configured to engage a cable braid of the cable , the cable preparation machine being configured to drive the braid blades inward by the arms moving to the advanced positions to pinch the cable braid inward against an inner insulator of the cable and flare outward an end of the cable braid forward of the braid blades , wherein the cable cutting device includes different blades for cutting insulator(s) and the cable braid during different cable cutting steps within the cable preparation machine without removing the cable from a cable cutting zone of the cable cutting device . a blade assembly having a plurality of arms and braid blades mounted to the corresponding arms , the arms and the braid blades being disposed about a cable opening configured to receive an end of a cable therein along a cable axis ; the arms being movable relative to each other between retracted positions and advanced positions, the arms being arranged to move the braid blades closer to each other within the cable opening as the arms are moved from the retracted positions to the advanced positions; the braid blades having edges configured to engage a cable braid of the cable , the cable preparation machine being configured to drive the braid blades inward by the arms moving to the advanced positions to pinch the cable braid inward against an inner insulator of the cable and flare outward an end of the cable braid forward of the braid blades , wherein the cable cutting device includes different blades for cutting insulator(s) and the cable braid during different cable cutting steps within the cable preparation machine without removing the cable from a cable cutting zone of the cable cutting device .
A carrier for guiding a window pane along a guide rail of a window lifter assembly, comprising a carrier base body and a clamping device arranged on the carrier base body , said clamping device has an inner clamping plate and an outer clamping plate resting against the carrier base body , between which the window pane provided with a pane aperture can be clamped and which include bores aligned with each other and with the pane aperture , through which bores a threaded sleeve and a clamping screw screwed to an internal thread of the threaded sleeve are inserted, wherein an external thread of the threaded sleeve is screwed to an internal thread of a screw element , and wherein the threaded sleeve is axially shiftably and non-rotatably held at the inner clamping plate , against whose outside the screw element rests in order to tension and release the clamping device , wherein the inner clamping plate forms a centric bearing surface for the window pane around its bore configured as a rim hole, wherein annular support webs arranged concentrically with respect to the bore of the inner clamping plate , which is configured as a rim hole, protrude from the side of the inner and outer clamping plates facing the window pane , and wherein the clamping screw is inserted through a bore of the carrier base body aligned with the rim hole of the inner clamping plate and the bore of the outer clamping plate and with its screw head rests against the outside of the carrier base body . wherein the inner clamping plate forms a centric bearing surface for the window pane around its bore configured as a rim hole, wherein annular support webs arranged concentrically with respect to the bore of the inner clamping plate , which is configured as a rim hole, protrude from the side of the inner and outer clamping plates facing the window pane , and wherein the clamping screw is inserted through a bore of the carrier base body aligned with the rim hole of the inner clamping plate and the bore of the outer clamping plate and with its screw head rests against the outside of the carrier base body .
A damper assembly comprising a cylinder with a piston assembly which is mounted for reciprocal movement therein and which divides the cylinder into separate chambers with a restricted flow path therebetween for passage of damping fluid contained within the cylinder , wherein the restricted flow path is defined between elements whose shape and/or relative position is designed to vary with temperature; wherein the elements are arranged so that the effective size of the restricted flow path therebetween reduces as temperature increases; wherein one of the elements is an elongate pin ; wherein the pin is located within a hole of the piston assembly having a cross-sectional shape whose area varies with respect to a longitudinal axis of the cylinder ; characterized in that the pin is arranged to be movably axially within said hole of the piston assembly .
A compound of formula (I) wherein: Tc is 99m Tc; R is hydrogen (-H) or a group of formula -(CH 2 ) n -A, wherein n is an integer of 1 or 2 and A is selected from the group consisting of hydrogen (-H), hydroxyl (-OH), methyl (-CH 3 ), carboxyl (-COOH), sodium carbonyl (-COONa), amino (-NH 2 ), cyanide (-CN), sulfonyl (-SO 3 H) and sodium sulfonyl (-SO 3 Na); R 1 is a group of formula -(CH 2 ) m -R 2 , wherein m is an integer of 1 to 6 and R 2 is selected from the group consisting of alkoxyl (-O-Ak), hydroxyl (-OH), carboxyl (-COOH), and amino (-NH 2 ); and ZY is a bidentate ligand, coordinated with Tc through a combination of electron-donating atoms selected from the group consisting of [O - ,S - ], [S - ,S - ], [O - ,S], [O,S - ], [N,S - ], [N - ,S], and [N - ,S - ], wherein ZY is not coordinated with Tc through [N,S - ] if R is -CH 3 and R 1 is -(CH 2 ) 2 -OCH 3 . Tc is 99m Tc; R is hydrogen (-H) or a group of formula -(CH 2 ) n -A, wherein n is an integer of 1 or 2 and A is selected from the group consisting of hydrogen (-H), hydroxyl (-OH), methyl (-CH 3 ), carboxyl (-COOH), sodium carbonyl (-COONa), amino (-NH 2 ), cyanide (-CN), sulfonyl (-SO 3 H) and sodium sulfonyl (-SO 3 Na); R 1 is a group of formula -(CH 2 ) m -R 2 , wherein m is an integer of 1 to 6 and R 2 is selected from the group consisting of alkoxyl (-O-Ak), hydroxyl (-OH), carboxyl (-COOH), and amino (-NH 2 ); and ZY is a bidentate ligand, coordinated with Tc through a combination of electron-donating atoms selected from the group consisting of [O - ,S - ], [S - ,S - ], [O - ,S], [O,S - ], [N,S - ], [N - ,S], and [N - ,S - ], wherein ZY is not coordinated with Tc through [N,S - ] if R is -CH 3 and R 1 is -(CH 2 ) 2 -OCH 3 .
A centrifugal separator structure configured for cleaning of crankcase gases from an internal combustion engine, wherein the centrifugal separator structure is a separate unit configured for attachment to a driving device, the centrifugal separator structure comprising a stationary housing and a separator rotor configured for rotation about a centre axis arranged inside the stationary housing , wherein the stationary housing comprises an inlet for crankcase gases, a gas outlet , and a liquid outlet , and wherein the separator rotor comprises a stack of separation discs , each separation disc of the stack of separation discs having a truncated conical shape, the separator rotor comprises an axle member , wherein the axle member is configured for connection to a shaft of a driving device for the centrifugal separator structure , and wherein the stack of separation discs is supported on the axle member characterised in that the axle member is un-journaled inside the stationary housing when the centrifugal separator structure is separate from the driving device , such that the separator rotor may rest against one or more inner surfaces of the stationary housing when the centrifugal separator structure is not connected to a driving device.
A composition comprising at least one of or a pharmaceutically acceptable salt, solvate, or hydrate thereof, for use in a method of treating a cell proliferative disorder selected from Proteus syndrome, Klippel-Trenaunay syndrome, CLOVES syndrome, fibroadipose hyperplasia, hemihyperplasia-multiple lipomatosis syndrome, megalencephaly, and Cowden syndrome, said method comprising administering, to a subject in need thereof, a therapeutically effective amount of the composition.
A filter element for a filter apparatus , wherein the filter element comprises at least one filter member comprising a permeable membrane layer, the filter member having a first filter surface for receiving a pressure and directed towards an internal cavity arranged inside the filter element, and a second filter surface for receiving solid particles filtered from a feed, wherein the filter member forms a capillary filter and the bubble point of the filter member is at least 0.2 bar, and by the filter element further comprising a frame member arranged to support the at least one filter member in such a manner that the internal cavity is formed, wherein the frame member is formed of a non-porous material, characterized by the frame member comprising a polymer material or a composition comprising a polymer material, and that the at least one frame member comprises between a connecting member end of the frame member and the filter member a material that is more flexible than the material of the filter member, wherein the connecting member end of the frame member is the end at which the filter element is arrangeable to the filter apparatus . at least one filter member comprising a permeable membrane layer, the filter member having a first filter surface for receiving a pressure and directed towards an internal cavity arranged inside the filter element, and a second filter surface for receiving solid particles filtered from a feed, wherein the filter member forms a capillary filter and the bubble point of the filter member is at least 0.2 bar, and by the filter element further comprising a frame member arranged to support the at least one filter member in such a manner that the internal cavity is formed, wherein the frame member is formed of a non-porous material, characterized by the frame member comprising a polymer material or a composition comprising a polymer material, and that the at least one frame member comprises between a connecting member end of the frame member and the filter member a material that is more flexible than the material of the filter member, wherein the connecting member end of the frame member is the end at which the filter element is arrangeable to the filter apparatus .
A method for generating modified Binaural Room Impulse Reponses (BRIRs) comprising: for a first BRIR having four regions including a direct region , an early reflections region , a head and torso influenced region , and a late reverberation region , identifying at least two of the four regions, and segmenting the first BRIR into the identified at least two regions ; wherein the first BRIR is a BRIR selected for an individual; performing a modifying operation on at least one of the at least two regions to generate at least one modified region ; and combining the at least one modified region and any unmodified regions where no processing operation is performed to form a modified BRIR for the individual, wherein the at least one modified region corresponds to changed sound attributes for a loudspeaker-room-listener interrelationship, characterised in that the first BRIR is selected based on audio-related physical properties of the individual, wherein the audio-related physical properties comprise features based on the size of the head of the individual and the size of the torso of the individual. for a first BRIR having four regions including a direct region , an early reflections region , a head and torso influenced region , and a late reverberation region , identifying at least two of the four regions, and segmenting the first BRIR into the identified at least two regions ; wherein the first BRIR is a BRIR selected for an individual; performing a modifying operation on at least one of the at least two regions to generate at least one modified region ; and combining the at least one modified region and any unmodified regions where no processing operation is performed to form a modified BRIR for the individual, wherein the at least one modified region corresponds to changed sound attributes for a loudspeaker-room-listener interrelationship, characterised in that the first BRIR is selected based on audio-related physical properties of the individual, wherein the audio-related physical properties comprise features based on the size of the head of the individual and the size of the torso of the individual.
An electronic stylus for a computing device comprising: a housing portion and a tip portion shaped to form the electronic stylus ; characterized by : a first electrode arranged in the tip portion configured to form a first communication channel with the computing device through the tip portion; and a second electrode arranged in a grip area of the housing portion configured to form a second communication channel with the computing device through the grip area and through a body of a user when the user is in contact with the grip area and with the computing device. a housing portion and a tip portion shaped to form the electronic stylus ; characterized by : a first electrode arranged in the tip portion configured to form a first communication channel with the computing device through the tip portion; and a second electrode arranged in a grip area of the housing portion configured to form a second communication channel with the computing device through the grip area and through a body of a user when the user is in contact with the grip area and with the computing device. a first electrode arranged in the tip portion configured to form a first communication channel with the computing device through the tip portion; and a second electrode arranged in a grip area of the housing portion configured to form a second communication channel with the computing device through the grip area and through a body of a user when the user is in contact with the grip area and with the computing device.
An assembly for motorizing a shutter comprising a first electromechanical module (M1), the first electromechanical module (M1) comprising a first electric motor (MA) and an electronic control unit , the motorizing assembly comprising a frame intended to be fastened to an architectural element of an opening in a building , the frame comprising fastening holes so as to fasten the frame to the architectural element , the motorizing assembly also comprising at least one slide extending along a longitudinal axis (X) of the frame and assembly elements , the assembly elements being arranged to cooperate with the slide , so as to guide the electromechanical module (M1) in translation relative to the frame , then to secure the electromechanical module (M1) to the frame , during the assembly of the electromechanical module (M1) to the frame , characterized in that the assembly elements comprise at least one screw , the screw comprising a head configured to be housed and to slide longitudinally inside the slide and to be kept in position relative to the frame along a direction perpendicular to the longitudinal axis (X) of the frame , the electromechanical module comprising a housing supporting an arm of the motorizing assembly , the housing comprising a base configured to be made to bear against the slide and a top opposite the base , the screw passing through the housing of the module (M1) and protruding from this housing on the side of the top of the housing , the assembly elements also comprising a tightening nut accessible at the top of the housing and cooperating with the screw .
Heated hose for delivering a liquid hotmelt adhesive or other substances which are fluid in the hot state from a melting unit to a discharge head, comprising: - a flexible hose for the passage of the liquid, - an insulating layer surrounding the flexible hose , - a heating device surrounding the flexible hose , wherein the heating device is disposed between the flexible hose and the insulating layer, wherein the insulating layer comprises a strip-shaped insulating material , wherein the strip-shaped insulating material is wound helically around the flexible hose , characterized in that the strip-shaped insulating material comprises an aerogel. - a flexible hose for the passage of the liquid, - an insulating layer surrounding the flexible hose , - a heating device surrounding the flexible hose , wherein the heating device is disposed between the flexible hose and the insulating layer,
An optical module (10, 10', 10", 10′′′, 10ʺʺ, 50, 50', 60), comprising: a substrate ; an optical detector carried by the substrate; a laser emitter carried by the substrate; a support structure carried by the substrate; an optical layer (19, 19', 19", 19′′′, 19ʺʺ, 19′′′ʺ) comprising: a fixed portion carried by the support structure; a movable portion affixed between opposite sides of the fixed portion by a spring structure ; a lens system carried by the movable portion; and a MEMS actuator for in-plane movement of the movable portion with respect to the fixed portion; wherein the lens system includes an objective lens portion and a beam shaping lens portion , the objective lens portion being positioned such that it overlies the optical detector , the beam shaping lens portion being positioned such that it overlies the laser emitter . a substrate ; an optical detector carried by the substrate; a laser emitter carried by the substrate; a support structure carried by the substrate; an optical layer (19, 19', 19", 19′′′, 19ʺʺ, 19′′′ʺ) comprising: a fixed portion carried by the support structure; a movable portion affixed between opposite sides of the fixed portion by a spring structure ; a lens system carried by the movable portion; and a MEMS actuator for in-plane movement of the movable portion with respect to the fixed portion; a fixed portion carried by the support structure; a movable portion affixed between opposite sides of the fixed portion by a spring structure ; a lens system carried by the movable portion; and a MEMS actuator for in-plane movement of the movable portion with respect to the fixed portion;