A portable ultrasound system , comprising: a user interface system comprising at least one display screen and at least one user input device ; a main circuit board module comprising a processing circuit configured to perform general computing operations and configured to receive ultrasound imaging data from a removable ultrasound module ; a housing containing the user interface system and the main circuit board module and having an opening configured to removably receive the removable ultrasound module ; and a connector configured to form an electrical connection with a corresponding second connector of the removable ultrasound module when the removable ultrasound module is fully inserted into the portable ultrasound system through the opening of the housing , wherein the connector comprises at least one guiding feature configured to align the connector and the second connector as the removable ultrasound module is inserted into the portable ultrasound system ; the portable ultrasound system is configured to provide electrical power to the removable ultrasound module , and receive the ultrasound imaging data from the removable ultrasound module ; characterized in that the portable ultrasound system further comprises a release lever , and the release lever is configured to rotate around an axis parallel to a bottom face of the housing during ejecting the removable ultrasound module from the portable ultrasound system ; the release lever comprises an interlock mechanism that is controlled by the main circuit board module ; and the interlock mechanism is normally engaged to prevent removal of the removable ultrasound module , and the main circuit board module disengages the interlock mechanism when the main circuit board module determines that it is safe to remove the removable ultrasound module . a user interface system comprising at least one display screen and at least one user input device ; a main circuit board module comprising a processing circuit configured to perform general computing operations and configured to receive ultrasound imaging data from a removable ultrasound module ; a housing containing the user interface system and the main circuit board module and having an opening configured to removably receive the removable ultrasound module ; and a connector configured to form an electrical connection with a corresponding second connector of the removable ultrasound module when the removable ultrasound module is fully inserted into the portable ultrasound system through the opening of the housing , wherein the connector comprises at least one guiding feature configured to align the connector and the second connector as the removable ultrasound module is inserted into the portable ultrasound system ; the portable ultrasound system is configured to provide electrical power to the removable ultrasound module , and receive the ultrasound imaging data from the removable ultrasound module ; characterized in that the portable ultrasound system further comprises a release lever , and the release lever is configured to rotate around an axis parallel to a bottom face of the housing during ejecting the removable ultrasound module from the portable ultrasound system ; the release lever comprises an interlock mechanism that is controlled by the main circuit board module ; and the interlock mechanism is normally engaged to prevent removal of the removable ultrasound module , and the main circuit board module disengages the interlock mechanism when the main circuit board module determines that it is safe to remove the removable ultrasound module . <EOS>