A system for detecting biomedical parameters from a subject seated on a toilet seat, comprising: a toilet seat assembly comprising at least a toilet seat ; a sensory unit comprising one or more electronic sensor modules configured to detect data from a user seated on the toilet seat in a normal position of use; a control unit connected to the sensory unit to receive data therefrom; and a power supply unit to supply power to the sensory unit and the control unit ; wherein the sensor modules comprise at least a contact measurement module having at least one sensor defining a direct interface with the user body for acquiring ECG signals from the user; and an ECG (electrocardiography) module , configured to process ECG signals received from the contact measurement module ; and wherein the sensor of the contact measurement module comprises a pair of sensor terminals positioned on the toilet seat so as to be in direct contact with respective thighs of the user seated on the toilet seat in a normal position of use; the sensor being configured to detect an electrical potential difference measured between said two terminals in contact with the body of the user; characterized in that the contact measurement module comprises only two terminals , positioned on opposite sides of the toilet seat and of a central axis (A) thereof, in positions corresponding to the left and right thighs of the user seated on the toilet seat ; the two terminals being separated by one or more insulating elements positioned between the terminals in the toilet seat ; and in that the ECG module is configured to perform signal transduction and conditioning with virtual ground of the ECG signals received from the contact measurement module , the ECG module having an electronic circuit configured so as to generate a virtual ground signal, i.e. to provide a virtual reference voltage, enabling the use of only two measurement terminals for the acquisition of ECG signals. wherein the sensor modules comprise at least a contact measurement module having at least one sensor defining a direct interface with the user body for acquiring ECG signals from the user; and an ECG (electrocardiography) module , configured to process ECG signals received from the contact measurement module ; and wherein the sensor of the contact measurement module comprises a pair of sensor terminals positioned on the toilet seat so as to be in direct contact with respective thighs of the user seated on the toilet seat in a normal position of use; the sensor being configured to detect an electrical potential difference measured between said two terminals in contact with the body of the user; characterized in that the contact measurement module comprises only two terminals , positioned on opposite sides of the toilet seat and of a central axis (A) thereof, in positions corresponding to the left and right thighs of the user seated on the toilet seat ; the two terminals being separated by one or more insulating elements positioned between the terminals in the toilet seat ; and in that the ECG module is configured to perform signal transduction and conditioning with virtual ground of the ECG signals received from the contact measurement module , the ECG module having an electronic circuit configured so as to generate a virtual ground signal, i.e. to provide a virtual reference voltage, enabling the use of only two measurement terminals for the acquisition of ECG signals. <EOS>