Method of designing and manufacturing a reverse shoe last and a straight shoe last used for manufacturing an article of footwear by means of a process that provides for fixing an upper disposed in reverse position on the reverse shoe last to a midsole ; said method comprising the following steps: - designing a shape and/or size of a foot (P) suitable for wearing the article of footwear to be manufactured; - designing and making a reverse shoe last whereon the upper is suitable for being disposed in reverse position during the fixing of the upper to the midsole ; - designing and making a straight shoe last suitable for being inserted inside the upper when the upper has been turned and disposed in straight position; wherein said straight shoe last is designed and made in such a way to substantially have the same shape as the foot (P); wherein said reverse shoe last is designed and made with a higher length (u2) than the length (u1) of the straight shoe last ; characterized in that said reverse shoe last and said straight shoe last are designed and made with instep-toe profiles (cp1, cp2) that extend along two different trajectories. wherein said instep-toe profile (cp1, cp2) of the reverse shoe last and of the straight shoe last comprises an end section in correspondence of the toe (p1, p2) of the shoe last ; wherein said reverse shoe last and said straight shoe last comprise a sole with a final section in correspondence of the toe (p1, p2); said final section being joined with said end section of the shoe last ; wherein said end section and said final section of the reverse shoe last define an angle (α) comprised between 52° and 62°; wherein said end section and said final section of the straight shoe last define an angle (β) comprised between 80° and 89°. - designing a shape and/or size of a foot (P) suitable for wearing the article of footwear to be manufactured; - designing and making a reverse shoe last whereon the upper is suitable for being disposed in reverse position during the fixing of the upper to the midsole ; - designing and making a straight shoe last suitable for being inserted inside the upper when the upper has been turned and disposed in straight position; wherein said straight shoe last is designed and made in such a way to substantially have the same shape as the foot (P); wherein said reverse shoe last is designed and made with a higher length (u2) than the length (u1) of the straight shoe last ; characterized in that said reverse shoe last and said straight shoe last are designed and made with instep-toe profiles (cp1, cp2) that extend along two different trajectories. wherein said instep-toe profile (cp1, cp2) of the reverse shoe last and of the straight shoe last comprises an end section in correspondence of the toe (p1, p2) of the shoe last ; wherein said reverse shoe last and said straight shoe last comprise a sole with a final section in correspondence of the toe (p1, p2); said final section being joined with said end section of the shoe last ; wherein said end section and said final section of the reverse shoe last define an angle (α) comprised between 52° and 62°; wherein said end section and said final section of the straight shoe last define an angle (β) comprised between 80° and 89°. <EOS>