A multiple-enzyme nanocapsule comprising at least two different enzymes, which form a multiple enzyme core, and a polymer network applied to the core to provide a polymeric network skin comprising a polymer composed of acryl monomeric units: wherein the nanocapsule is obtainable by: (a) linking alcohol oxidase and catalase enzymes to one another with a linkage formed by a first polynucleotide coupled to the alcohol oxidase enzyme and a second polynucleotide coupled to the catalase enzyme, wherein the first polynucleotide and second polynucleotide are hybridizable so as to form a linkage; (b) derivatising the linked enzymes with acryl groups; and (c) polymerizing the acryl monomeric units and a crosslinker with the linked derivatized enzymes in situ to wrap the alcohol oxidase and catalase enzymes within the polymeric network skin wherein the polymeric network skin is bound to an acryl group on at least one of said enzymes, wherein the alcohol oxidase enzyme generates hydrogen peroxide in a first enzymatic reaction with an alcohol, and catalase enzyme reacts with hydrogen peroxide in a second enzymatic reaction; and the polymeric network skin encapsulates the alcohol oxidase and the catalase enzyme, and the polymeric network skin exhibits a permeability sufficient to allow the alcohol to diffuse from an external environment outside of the polymeric network skin to alcohol oxidase so that hydrogen peroxide is generated and the polymeric network skin further exhibits a permeability sufficient to allow hydrogen peroxide to diffuse away from the alcohol oxidase enzyme and to the catalase enzyme so that the second enzymatic reaction occurs. wherein the nanocapsule is obtainable by: (a) linking alcohol oxidase and catalase enzymes to one another with a linkage formed by a first polynucleotide coupled to the alcohol oxidase enzyme and a second polynucleotide coupled to the catalase enzyme, wherein the first polynucleotide and second polynucleotide are hybridizable so as to form a linkage; (b) derivatising the linked enzymes with acryl groups; and (c) polymerizing the acryl monomeric units and a crosslinker with the linked derivatized enzymes in situ to wrap the alcohol oxidase and catalase enzymes within the polymeric network skin wherein the polymeric network skin is bound to an acryl group on at least one of said enzymes, wherein the alcohol oxidase enzyme generates hydrogen peroxide in a first enzymatic reaction with an alcohol, and catalase enzyme reacts with hydrogen peroxide in a second enzymatic reaction; and (a) linking alcohol oxidase and catalase enzymes to one another with a linkage formed by a first polynucleotide coupled to the alcohol oxidase enzyme and a second polynucleotide coupled to the catalase enzyme, wherein the first polynucleotide and second polynucleotide are hybridizable so as to form a linkage; (b) derivatising the linked enzymes with acryl groups; and (c) polymerizing the acryl monomeric units and a crosslinker with the linked derivatized enzymes in situ to wrap the alcohol oxidase and catalase enzymes within the polymeric network skin wherein the polymeric network skin is bound to an acryl group on at least one of said enzymes, the polymeric network skin encapsulates the alcohol oxidase and the catalase enzyme, and the polymeric network skin exhibits a permeability sufficient to allow the alcohol to diffuse from an external environment outside of the polymeric network skin to alcohol oxidase so that hydrogen peroxide is generated and the polymeric network skin further exhibits a permeability sufficient to allow hydrogen peroxide to diffuse away from the alcohol oxidase enzyme and to the catalase enzyme so that the second enzymatic reaction occurs. <EOS>