A method for stimulating T cells and generating a composition comprising T cells expressing a genetically engineered recombinant receptor, the method comprising: (a) incubating, under stimulating conditions, an input composition comprising T cells comprising a culture-initiating amount of naïve-like T cells or a CD8+ T cell subset thereof, thereby producing a stimulated composition, wherein: (i) the stimulating conditions comprise the presence of a stimulatory reagent comprising a primary agent that is an anti-CD3 antibody and a secondary agent that is an anti-CD28 antibody, wherein the stimulatory reagent activates one or more intracellular signaling domains of one or more components of a TCR complex and/or one or more intracellular signaling domains of one or more costimulatory molecules, thereby generating a stimulated composition, and wherein the stimulation time is for between 2 and 6 days; and (ii) the culture-initiating amount of naïve-like T cells or a CD8+ T cell subset thereof is or is at least 2 × 10 8 of the naïve-like T cells or a CD8+ T cell subset thereof, wherein the naïve-like T cells or the naive-like CD8+ T cells are CD27+ and CCR7+; and (b) introducing into the stimulated cell composition a nucleic acid encoding a genetically engineered recombinant receptor, wherein the method thereby generates an output composition comprising T cells expressing the genetically engineered recombinant receptor, wherein the introducing is carried out during at least a portion of the incubating or is carried out subsequent to the incubating. (a) incubating, under stimulating conditions, an input composition comprising T cells comprising a culture-initiating amount of naïve-like T cells or a CD8+ T cell subset thereof, thereby producing a stimulated composition, wherein: (i) the stimulating conditions comprise the presence of a stimulatory reagent comprising a primary agent that is an anti-CD3 antibody and a secondary agent that is an anti-CD28 antibody, wherein the stimulatory reagent activates one or more intracellular signaling domains of one or more components of a TCR complex and/or one or more intracellular signaling domains of one or more costimulatory molecules, thereby generating a stimulated composition, and wherein the stimulation time is for between 2 and 6 days; and (ii) the culture-initiating amount of naïve-like T cells or a CD8+ T cell subset thereof is or is at least 2 × 10 8 of the naïve-like T cells or a CD8+ T cell subset thereof, wherein the naïve-like T cells or the naive-like CD8+ T cells are CD27+ and CCR7+; and (i) the stimulating conditions comprise the presence of a stimulatory reagent comprising a primary agent that is an anti-CD3 antibody and a secondary agent that is an anti-CD28 antibody, wherein the stimulatory reagent activates one or more intracellular signaling domains of one or more components of a TCR complex and/or one or more intracellular signaling domains of one or more costimulatory molecules, thereby generating a stimulated composition, and wherein the stimulation time is for between 2 and 6 days; and (ii) the culture-initiating amount of naïve-like T cells or a CD8+ T cell subset thereof is or is at least 2 × 10 8 of the naïve-like T cells or a CD8+ T cell subset thereof, wherein the naïve-like T cells or the naive-like CD8+ T cells are CD27+ and CCR7+; and (b) introducing into the stimulated cell composition a nucleic acid encoding a genetically engineered recombinant receptor, wherein the method thereby generates an output composition comprising T cells expressing the genetically engineered recombinant receptor, wherein the introducing is carried out during at least a portion of the incubating or is carried out subsequent to the incubating. <EOS>