A system suitable for operating a pacemaker comprising: a blood pressure monitor couplable to a patient; a memory communicated to the monitor for storing a number of blood pressure readings; a processor communicated to the memory for determining a baseline blood pressure reading; the system being characterized in that the processor determines the following parameters to use to control the pacemaker for blood pressure regulation: a target BP, blood pressure, a lower limit of acceptable BP; a target treatment interval in minutes and/or target pacing rate change per treatment interval at a predetermined pacing rate change percentage; wherein the processor determines, while monitoring blood pressure, if blood pressure exceeds the target BP, wherein the pacemaker has a controllable pacing rate to treat the patient by: increasing the pacing rate of the pacemaker by either a default level of 5% per treatment, or by a different predetermined value; wherein the processor monitors the BP for a predetermined time period to establish the new blood pressure baseline; compares BP to a preselected optimal BP; increasing the pacing rate of the pacemaker by a predetermined incremental amount; and repeats the steps of comparing BP and increasing the pacing rate of the pacemaker until either the BP falls to the target BP, or the pacing rate of the pacemaker exceeds a predetermined maximal value. a blood pressure monitor couplable to a patient; a memory communicated to the monitor for storing a number of blood pressure readings; a processor communicated to the memory for determining a baseline blood pressure reading; the system being characterized in that the processor determines the following parameters to use to control the pacemaker for blood pressure regulation: a target BP, blood pressure, a lower limit of acceptable BP; a target treatment interval in minutes and/or target pacing rate change per treatment interval at a predetermined pacing rate change percentage; wherein the processor determines, while monitoring blood pressure, if blood pressure exceeds the target BP, wherein the pacemaker has a controllable pacing rate to treat the patient by: increasing the pacing rate of the pacemaker by either a default level of 5% per treatment, or by a different predetermined value; wherein the processor monitors the BP for a predetermined time period to establish the new blood pressure baseline; compares BP to a preselected optimal BP; increasing the pacing rate of the pacemaker by a predetermined incremental amount; and repeats the steps of comparing BP and increasing the pacing rate of the pacemaker until either the BP falls to the target BP, or the pacing rate of the pacemaker exceeds a predetermined maximal value. the system being characterized in that the processor determines the following parameters to use to control the pacemaker for blood pressure regulation: a target BP, blood pressure, a lower limit of acceptable BP; a target treatment interval in minutes and/or target pacing rate change per treatment interval at a predetermined pacing rate change percentage; wherein the processor determines, while monitoring blood pressure, if blood pressure exceeds the target BP, wherein the pacemaker has a controllable pacing rate to treat the patient by: increasing the pacing rate of the pacemaker by either a default level of 5% per treatment, or by a different predetermined value; wherein the processor monitors the BP for a predetermined time period to establish the new blood pressure baseline; compares BP to a preselected optimal BP; increasing the pacing rate of the pacemaker by a predetermined incremental amount; and repeats the steps of comparing BP and increasing the pacing rate of the pacemaker until either the BP falls to the target BP, or the pacing rate of the pacemaker exceeds a predetermined maximal value. <EOS>