mhurhangee/patent-ind-claim-en huggingface dataset:
A stabilized formulation for sustained release of a vitamin D compound, the formulation comprising a mixture of: one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3 ; a stabilizing agent comprising a material selected from the group consisting of: cellulose compounds, poloxamers, poly(ethylene oxide) polymers, povidones, fumed silicas, and combinations thereof, wherein the stabilizing agent is present in an amount of at least about 5% of the formulation, based on the total weight of the formulation excluding any additional coatings or shells (wt%), which is effective to maintain a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25°C and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions; and a secondary additive comprising one or more compounds selected from the group consisting of: calcium salts, bisphosphonates, calcimimetics, nicotinic acid, iron, phosphate binders, cholecalciferol, ergocalciferol, active Vitamin D sterols, glycemic control agents, hypertension control agents, antineoplastic agents, and inhibitors of CYP24, inhibitors of cytochrome P450 enzymes that can degrade vitamin D agents. one or both of 25-hydroxyvitamin D 2 and 25-hydroxyvitamin D 3 ; a stabilizing agent comprising a material selected from the group consisting of: cellulose compounds, poloxamers, poly(ethylene oxide) polymers, povidones, fumed silicas, and combinations thereof, wherein the stabilizing agent is present in an amount of at least about 5% of the formulation, based on the total weight of the formulation excluding any additional coatings or shells (wt%), which is effective to maintain a difference of less than 30% between the amount of vitamin D compound released at any given time point after four hours during in vitro dissolution after two months exposure to storage conditions of 25°C and 60% relative humidity and the amount released at the same dissolution time point during in vitro dissolution conducted prior to exposing the formulation to the storage conditions; and a secondary additive comprising one or more compounds selected from the group consisting of: calcium salts, bisphosphonates, calcimimetics, nicotinic acid, iron, phosphate binders, cholecalciferol, ergocalciferol, active Vitamin D sterols, glycemic control agents, hypertension control agents, antineoplastic agents, and inhibitors of CYP24, inhibitors of cytochrome P450 enzymes that can degrade vitamin D agents.
A device for evaluating or improving perceptual-cognitive abilities of a subject , comprising: a display of virtual objects moving in a given three-dimensional environment during successive tests, with the subject in visual contact with the virtual objects moving in the three-dimensional environment ; and a controller of the display of the virtual objects moving in the given three-dimensional environment during the successive tests, characterized in that the controller of the display is configured for changing a speed of movement of the virtual objects in the three-dimensional environment , wherein the display immerses the subject in the three-dimensional environment , the display comprises a set of surfaces on which images are displayed to form the three-dimensional environment , the images displayed on the surfaces are stereoscopic images, the display comprises a shutter visual implement enabling the subject to perceive, in three dimensions, the virtual objects , positions of the virtual objects , and the three-dimensional environment , the display further comprises a positional sensor mounted to the shutter visual implement to track a position of the subject's head, and the controller controls the display to correct in real-time a visual perspective relative to the subject's head position. a display of virtual objects moving in a given three-dimensional environment during successive tests, with the subject in visual contact with the virtual objects moving in the three-dimensional environment ; and a controller of the display of the virtual objects moving in the given three-dimensional environment during the successive tests, characterized in that the controller of the display is configured for changing a speed of movement of the virtual objects in the three-dimensional environment , wherein the display immerses the subject in the three-dimensional environment , the display comprises a set of surfaces on which images are displayed to form the three-dimensional environment , the images displayed on the surfaces are stereoscopic images, the display comprises a shutter visual implement enabling the subject to perceive, in three dimensions, the virtual objects , positions of the virtual objects , and the three-dimensional environment , the display further comprises a positional sensor mounted to the shutter visual implement to track a position of the subject's head, and the controller controls the display to correct in real-time a visual perspective relative to the subject's head position.
A latch-bolt assembly for a lock , wherein are defined respectively vertical to each other a vertical axis , a transverse axis and a longitudinal axis , comprising: • a latch-bolt shaft for the displaceable arrangement in a housing of the lock along the longitudinal axis , • a first latch-bolt head , which is attached to the latch-bolt shaft pivotably about a first pivot axis , wherein the first pivot axis is parallel to the vertical axis , and • a second latch-bolt head , which is attached to the latch-bolt shaft pivotably about a second pivot axis , wherein the second pivot axis is parallel to the vertical axis , and characterized in that the first and the second pivot axes are spaced apart from each other. • a latch-bolt shaft for the displaceable arrangement in a housing of the lock along the longitudinal axis , • a first latch-bolt head , which is attached to the latch-bolt shaft pivotably about a first pivot axis , wherein the first pivot axis is parallel to the vertical axis , and • a second latch-bolt head , which is attached to the latch-bolt shaft pivotably about a second pivot axis , wherein the second pivot axis is parallel to the vertical axis , and
A sample filtration device comprising: a flexible connector comprising a funnel shaped opening leading to a tube portion; an input substrate comprising an inlet contracting hole in fluid connection with the tube portion; a filter membrane in fluid communication with the inlet contracting hole and configured to filter the sample into a filtrate; a double-sided pressure sensitive adhesive layer configured to join to the filter membrane, the double-sided adhesive layer comprising a pressure sensitive adhesive layer disposed on either side of a substrate and further comprising a central cutout configured to expose a central portion of the filter membrane; and an output substrate comprising one or more channels in fluid communication with the filtrate from the filter, the one or more channels in fluid communication with an outlet of the output substrate. a flexible connector comprising a funnel shaped opening leading to a tube portion; an input substrate comprising an inlet contracting hole in fluid connection with the tube portion; a filter membrane in fluid communication with the inlet contracting hole and configured to filter the sample into a filtrate; a double-sided pressure sensitive adhesive layer configured to join to the filter membrane, the double-sided adhesive layer comprising a pressure sensitive adhesive layer disposed on either side of a substrate and further comprising a central cutout configured to expose a central portion of the filter membrane; and an output substrate comprising one or more channels in fluid communication with the filtrate from the filter, the one or more channels in fluid communication with an outlet of the output substrate.
Motor vehicle door latch with • a locking mechanism comprising at least two locking mechanism components such as a catch and a pawl , whereby • at least one locking mechanism component has at least one metallic base body , a plastic coating , and a flexible damping element as component elements ; • the base body and the coating are coupled to one another by means of a detachable io push/pull connection; characterized in that • the plastic of the coating is a high strength plastic; • the coating and the damping element are coupled to one another by means of a detachable push/pull connection; • the damping element is latched to the coating ; • the damping element is equipped with ratchet studs that engage in ratchet recesses of the coating in the installed state. • a locking mechanism comprising at least two locking mechanism components such as a catch and a pawl , whereby • at least one locking mechanism component has at least one metallic base body , a plastic coating , and a flexible damping element as component elements ; • the base body and the coating are coupled to one another by means of a detachable io push/pull connection; • the plastic of the coating is a high strength plastic; • the coating and the damping element are coupled to one another by means of a detachable push/pull connection; • the damping element is latched to the coating ; • the damping element is equipped with ratchet studs that engage in ratchet recesses of the coating in the installed state.
A process for preparing a complex of at least one cyclodextrin and at least one active pharmaceutical ingredient comprising the steps of: a. Preparing a first solution (solution A) comprising at least one cyclodextrin and at least one solvent; b. Preparing a second solution (solution B) comprising at least one dissolved, partially dissolved or suspended API; c. Mixing said solution A and solution B by means of a microfludization system to produce a solution and/or suspension of at least one of said complex; d. Isolating said solution and/or suspension and/or optionally drying it; and e. Optionally collecting a powdered form of the complex. a. Preparing a first solution (solution A) comprising at least one cyclodextrin and at least one solvent; b. Preparing a second solution (solution B) comprising at least one dissolved, partially dissolved or suspended API; c. Mixing said solution A and solution B by means of a microfludization system to produce a solution and/or suspension of at least one of said complex; d. Isolating said solution and/or suspension and/or optionally drying it; and e. Optionally collecting a powdered form of the complex.
An image reconstruction method implemented on at least one device each of which has at least one processor and storage, the method comprising: obtaining image data, at least a portion of the image data relating to a region of interest (ROI); determining a regularization item according to a formula: R I = ∑ i j k ∈ Ω ∇ I i j k T A i j k ∇ I i j k , wherein I represents the image data, R ( I ) represents the regularization item, (i,j,k) represents a voxel index of the image data, ∇I { i,j,k } represents a gradient of the voxel (i,j, k), ∇ I i j k T represents a transpose of the gradient of the voxel (i,j, k), Ω represents a whole image data domain, and A { i,j,k } represents a matrix corresponding to orientation information of the voxel (i, j, k) in smoothed image data; modifying the image data based on the regularization item; and generating an image based on the modified image data. obtaining image data, at least a portion of the image data relating to a region of interest (ROI); determining a regularization item according to a formula: R I = ∑ i j k ∈ Ω ∇ I i j k T A i j k ∇ I i j k , wherein I represents the image data, R ( I ) represents the regularization item, (i,j,k) represents a voxel index of the image data, ∇I { i,j,k } represents a gradient of the voxel (i,j, k), ∇ I i j k T represents a transpose of the gradient of the voxel (i,j, k), Ω represents a whole image data domain, and A { i,j,k } represents a matrix corresponding to orientation information of the voxel (i, j, k) in smoothed image data; modifying the image data based on the regularization item; and generating an image based on the modified image data. R I = ∑ i j k ∈ Ω ∇ I i j k T A i j k ∇ I i j k , wherein I represents the image data, R ( I ) represents the regularization item, (i,j,k) represents a voxel index of the image data, ∇I { i,j,k } represents a gradient of the voxel (i,j, k), ∇ I i j k T represents a transpose of the gradient of the voxel (i,j, k), Ω represents a whole image data domain, and A { i,j,k } represents a matrix corresponding to orientation information of the voxel (i, j, k) in smoothed image data; modifying the image data based on the regularization item; and generating an image based on the modified image data.
Filling device for filling a container with a filling product, preferably in a beverage filling plant, comprising: a filling member that comprises a gas conduit for evacuating the container to be filled to a reduced pressure (P low ) and a filling product conduit for introducing a filling product from a base reservoir under overpressure into the evacuated container ; a dosage reservoir ; and at least one dosage supply line, preferably a dosage valve , which is configured to introduce a dosage component from the dosage reservoir into the filling product conduit . a filling member that comprises a gas conduit for evacuating the container to be filled to a reduced pressure (P low ) and a filling product conduit for introducing a filling product from a base reservoir under overpressure into the evacuated container ; a dosage reservoir ; and at least one dosage supply line, preferably a dosage valve , which is configured to introduce a dosage component from the dosage reservoir into the filling product conduit .
Method for producing a drive belt of elastomer material, which is driven to run around under tensile stress and is provided with a drive side, a rear side and with lateral surfaces, with a built-in electronic circuit or electronic device , the drive belt having tension members or cords arranged in the longitudinal direction, - wherein fabrication takes place on a building drum and in the form of a cylindrical blank, the length of which corresponds to a multiple of the width of the drive belt, wherein, during the fabrication and before the vulcanization of the cylindrical blank, intermediate plies or strips which extend at least over part-lengths of the cylindrical blank and are of material which cannot be crosslinked by vulcanization are inserted into the blank structure in subregions of the blank, - wherein, after the fabrication, the blank is completely vulcanized and cut into individual drive belts, wherein after that the intermediate plies or strips are removed from the individually separated drive belts, and there is inserted into the shallow empty space or intermediate space thereby created an electronic circuit or electronic device which is formed in its three-dimensional or two-dimensional extents in such a way that the intermediate space is only partially filled. - wherein fabrication takes place on a building drum and in the form of a cylindrical blank, the length of which corresponds to a multiple of the width of the drive belt, wherein, during the fabrication and before the vulcanization of the cylindrical blank, intermediate plies or strips which extend at least over part-lengths of the cylindrical blank and are of material which cannot be crosslinked by vulcanization are inserted into the blank structure in subregions of the blank, - wherein, after the fabrication, the blank is completely vulcanized and cut into individual drive belts, wherein after that the intermediate plies or strips are removed from the individually separated drive belts, and there is inserted into the shallow empty space or intermediate space thereby created an electronic circuit or electronic device which is formed in its three-dimensional or two-dimensional extents in such a way that the intermediate space is only partially filled.
A light emitting device package comprising: a first frame including a first opening part (TH1) provided through the first frame ; a second frame spaced apart from the first frame and including a second opening part (TH2) provided through the second frame ; a body supporting the first and second frames and including a cavity; a light emitting device disposed in the cavity; an adhesion layer disposed between the body and the light emitting device; a reflection layer disposed on a side surface of the cavity; a transparent layer disposed on the reflection layer and surrounding the light emitting device ; wherein the light emitting device includes a first bonding part , and a second bonding part , wherein a phosphor layer is disposed on the transparent layer; wherein the first and second opening parts overlap the light emitting device; the body between the first opening part (TH1) and the second opening part (TH2) includes a recess (R) on an upper surface thereof, wherein the adhesion layer is disposed in the recess (R), a first conductive layer is disposed in the first opening part (TH1), a second conductive layer is disposed in the second opening part (TH2), wherein the first conductive layer is electrically connected to the first bonding part and the second conductive layer is electrically connected to the second bonding part , wherein a width of the first bonding part is greater than a width of the first conductive layer , wherein a width of the second bonding part is greater than a width of the second conductive layer . a first frame including a first opening part (TH1) provided through the first frame ; a second frame spaced apart from the first frame and including a second opening part (TH2) provided through the second frame ; a body supporting the first and second frames and including a cavity; a light emitting device disposed in the cavity; an adhesion layer disposed between the body and the light emitting device; a reflection layer disposed on a side surface of the cavity; a transparent layer disposed on the reflection layer and surrounding the light emitting device ; wherein the light emitting device includes a first bonding part , and a second bonding part , wherein a phosphor layer is disposed on the transparent layer; wherein the first and second opening parts overlap the light emitting device; the body between the first opening part (TH1) and the second opening part (TH2) includes a recess (R) on an upper surface thereof, wherein the adhesion layer is disposed in the recess (R), a first conductive layer is disposed in the first opening part (TH1), a second conductive layer is disposed in the second opening part (TH2), wherein the first conductive layer is electrically connected to the first bonding part and the second conductive layer is electrically connected to the second bonding part , wherein a width of the first bonding part is greater than a width of the first conductive layer , wherein a width of the second bonding part is greater than a width of the second conductive layer .
Electromechanical brake actuator of a commercial vehicle disk brake, having: - an electric motor for generating a drive torque, - a cam disk which is operatively connected to the electric motor and is mounted in a rotationally movable manner, and - a brake plunger which can be moved along a plunger axis for the actuation of a brake lever of the brake , the brake plunger , at its end facing the cam disk , having a plunger head , and the plunger head enclosing a rolling element which is mounted by means of bearings , characterized in that the cam disk and the brake plunger have contact faces which are in contact with one another and slide or roll on one another for the direct transmission of the drive torque between the cam disk and the brake plunger . - an electric motor for generating a drive torque, - a cam disk which is operatively connected to the electric motor and is mounted in a rotationally movable manner, and - a brake plunger which can be moved along a plunger axis for the actuation of a brake lever of the brake , the brake plunger , at its end facing the cam disk , having a plunger head , and the plunger head enclosing a rolling element which is mounted by means of bearings , characterized in that the cam disk and the brake plunger have contact faces which are in contact with one another and slide or roll on one another for the direct transmission of the drive torque between the cam disk and the brake plunger .
A method of estimating the energy production of a wind turbine or group of wind turbines, the method comprising: obtaining, from a climate library, climate data in respect of a selected geographical location, the climate data comprising climatic conditions including at least wind speed, wind direction and wind shear at a plurality of different heights above the surface at the selected geographical location; clustering the climate data into a plurality of groups based on wind speed, wind direction and wind shear, each group being represented by a representative wind speed and/or direction profile; generating a plurality of power curves, each power curve defining a power output of a wind turbine as a function of wind speed for the respective representative wind speed and/or direction profiles; and estimating an energy production for the wind turbine or group of wind turbines using the generated power curves and wind speed data obtained from the climate library as part of the climate data or based on wind speed measurements taken at the selected geographical location, wherein the energy production is estimated by weighting the contribution of each power curve in accordance with the expected relative frequency of the climatic conditions to which those power curves relate. obtaining, from a climate library, climate data in respect of a selected geographical location, the climate data comprising climatic conditions including at least wind speed, wind direction and wind shear at a plurality of different heights above the surface at the selected geographical location; clustering the climate data into a plurality of groups based on wind speed, wind direction and wind shear, each group being represented by a representative wind speed and/or direction profile; generating a plurality of power curves, each power curve defining a power output of a wind turbine as a function of wind speed for the respective representative wind speed and/or direction profiles; and estimating an energy production for the wind turbine or group of wind turbines using the generated power curves and wind speed data obtained from the climate library as part of the climate data or based on wind speed measurements taken at the selected geographical location, wherein the energy production is estimated by weighting the contribution of each power curve in accordance with the expected relative frequency of the climatic conditions to which those power curves relate.
A fish ladder setup, in particular in the area of the outlet of a channel of a fish pass , with a device for generating an dotation flow, characterized by a vortex throttle disposed in a water flow with a downstream assembly for slowing down and/or orienting the water flow exiting the vortex throttle .