mhurhangee/patent-ind-claim-en huggingface dataset:
A composition comprising a complex of Factor VIII and a Von Willebrand Factor peptide, wherein the Von Willebrand Factor peptide consists of the amino acids 764 to 2128 of SEQ ID NO: 1.
A method of operating a user equipment, UE, device in communication with a communication system comprising a plurality of satellite transmission points, the method performed by the UE device and the method comprising: receiving a measurement and reporting configuration from a base station of the system; measuring in accordance with the received measurement and reporting configuration a received signal parameter of a signal received from a first satellite transmission point of the system, the received signal parameter being a received signal strength; triggering a transmission of a measurement report, the measurement report being in accordance with the received measurement and reporting configuration, the triggering being dependent on the measurement by the UE device of the received signal parameter of the signal received from the first satellite transmission point of the system and the triggering being dependent on a comparison of the measured signal parameter with a current value of a time varying threshold; and transmitting the measurement report to the base station of the system when the measured signal parameter deviates from an expected value by more than the threshold, wherein the threshold is a predetermined time-variant function dependent on a time-dependent expected position of the UE device with respect to the first satellite transmission point and wherein at least part of the base station is part of the first satellite transmission point. receiving a measurement and reporting configuration from a base station of the system; measuring in accordance with the received measurement and reporting configuration a received signal parameter of a signal received from a first satellite transmission point of the system, the received signal parameter being a received signal strength; triggering a transmission of a measurement report, the measurement report being in accordance with the received measurement and reporting configuration, the triggering being dependent on the measurement by the UE device of the received signal parameter of the signal received from the first satellite transmission point of the system and the triggering being dependent on a comparison of the measured signal parameter with a current value of a time varying threshold; and transmitting the measurement report to the base station of the system when the measured signal parameter deviates from an expected value by more than the threshold, wherein the threshold is a predetermined time-variant function dependent on a time-dependent expected position of the UE device with respect to the first satellite transmission point and wherein at least part of the base station is part of the first satellite transmission point.
An effective amount of a bromodomain and extra terminal (BET) inhibitor and a protein phosphatase 2A (PP2A) activator for use in treating cancer in a subject in need thereof, wherein the cancer is resistant to treatment by the BET inhibitor alone.
A management method for multiple communication devices, wherein the multiple communication devices comprise a host device configured to electrically connect to a device platform and a first peripheral device configured to electrically connect to the device platform , and the management method comprises: by the host device , detecting (S201) a connection of the first peripheral device through the device platform ; by the host device , receiving (S203) a first device identifier provided by the first peripheral device through the device platform ; by the host device , storing (S204) the first device identifier in the host device ; and by the host device , wirelessly pairing (S205) the host device with the first peripheral device , according to the first device identifier stored in the host device , to enable a first wireless communication between the host device and the first peripheral device ; characterised in that the multiple communication devices further comprise a second peripheral device configured to electrically connect to the device platform and provide a second device identifier, and if the second peripheral device is previously connected to the device platform with the host device and the host device detects a disconnection of the second peripheral device from the device platform , the management method further comprises: by the host device , removing (S213) the second device identifier from the host device if the second device identifier is stored in the host device . by the host device , detecting (S201) a connection of the first peripheral device through the device platform ; by the host device , receiving (S203) a first device identifier provided by the first peripheral device through the device platform ; by the host device , storing (S204) the first device identifier in the host device ; and by the host device , wirelessly pairing (S205) the host device with the first peripheral device , according to the first device identifier stored in the host device , to enable a first wireless communication between the host device and the first peripheral device ; characterised in that the multiple communication devices further comprise a second peripheral device configured to electrically connect to the device platform and provide a second device identifier, and if the second peripheral device is previously connected to the device platform with the host device and the host device detects a disconnection of the second peripheral device from the device platform , the management method further comprises: by the host device , removing (S213) the second device identifier from the host device if the second device identifier is stored in the host device .
A weatherseal assembly for a window opening comprising: first and second legs joined by an interconnecting leg to form a generally U-shaped, rigid channel enclosing a window receiving cavity wherein the first and second legs of the channel each comprise an indented portion that extends into the cavity; first and second seal portions integrated with and secured to the channel and providing first and second lips that extend into a portion of the cavity and are adapted to seal against an associated vehicle window; a door frame assembly including an inner door panel and an outer door panel having end portions spaced apart by a first dimension (X) to receive the rigid channel ; and a mechanism for securing the channel to the door frame assembly , characterized in that the first lip is co-formed with the first leg of the rigid channel , the second lip is co-formed with the second leg of the rigid channel and the first lip extends from connection with the first leg in a region adjacent the indented portion thereof. first and second legs joined by an interconnecting leg to form a generally U-shaped, rigid channel enclosing a window receiving cavity wherein the first and second legs of the channel each comprise an indented portion that extends into the cavity; first and second seal portions integrated with and secured to the channel and providing first and second lips that extend into a portion of the cavity and are adapted to seal against an associated vehicle window; a door frame assembly including an inner door panel and an outer door panel having end portions spaced apart by a first dimension (X) to receive the rigid channel ; and a mechanism for securing the channel to the door frame assembly ,
A polyethylene resin comprising from 0.6 to 1 weight % of 1-octene and the balance ethylene, having a density from 0.948 to 0.953 g/cc, a melt index determined according to ASTM1238 under a load of 2.16 kg at a temperature of 190°C (I 2 ) from 1.0 to 1.5 g/10 minutes; a melt index determined according to ASTM1238 under a load of 21.6 kg at a temperature of 190°C (I 21 ) from 32 to 55 g/10 minutes; a weight average molecular weight (Mw) determined by gel permeation chromatography from 90,000 to 130,000; a number average molecular weight (Mn) determined by gel permeation chromatography (GPC) from 20,000 to 40,000; a z average molecular weight (Mz) from 240,000 to 360,000; an Mw/Mn from 2.9 to 4; an Mz/Mw from 2.9 to 3.2; and having a CBDI from 80 to 95, the molecular weight distribution determined by GPC of said polymer being deconvoluted into three components comprising: from 20 to 40 weight % of a first component having a calculated weight average molecular weight (Mw) being from 170,000 to 265,000; a calculated number average molecular weight (Mn) from 90,000 to 140,000; a z average molecular weight 390,000 to 520,000 and an estimated density from 0.921 to 0.930 g/cc; from 40 to 70 weight % of a second component having a calculated weight average molecular weight (Mw) being from 20,000 to 57,000; a calculated number average molecular weight (Mn) from 10,000 to 27,000; a z average molecular weight 30,000 to 72,000 and an estimated density from 0.948 to 0.953 g/cc, provided that the density difference between component two and component one is less than 0.030 g/cc; and from 3 to 20 weight % of a third component having a calculated weight average molecular weight (Mw) being from 60,000 to 130,000; a calculated number average molecular weight (Mn) from 30,000 to 65,000; a z average molecular weight 90,000 to 180,000 and an estimated density from 0.935 to 0.945 g/cc. from 20 to 40 weight % of a first component having a calculated weight average molecular weight (Mw) being from 170,000 to 265,000; a calculated number average molecular weight (Mn) from 90,000 to 140,000; a z average molecular weight 390,000 to 520,000 and an estimated density from 0.921 to 0.930 g/cc; from 40 to 70 weight % of a second component having a calculated weight average molecular weight (Mw) being from 20,000 to 57,000; a calculated number average molecular weight (Mn) from 10,000 to 27,000; a z average molecular weight 30,000 to 72,000 and an estimated density from 0.948 to 0.953 g/cc, provided that the density difference between component two and component one is less than 0.030 g/cc; and from 3 to 20 weight % of a third component having a calculated weight average molecular weight (Mw) being from 60,000 to 130,000; a calculated number average molecular weight (Mn) from 30,000 to 65,000; a z average molecular weight 90,000 to 180,000 and an estimated density from 0.935 to 0.945 g/cc.
A process for coating a part comprising the steps of: a. loading at least one bond coated part into a load chamber; b. moving the at least one bond coated part from the load chamber to a preheat chamber; c. backfilling said preheat chamber with a protective atmosphere of carbon dioxide; d. reducing the pressure in the preheat chamber to in the range of 1.33Nm -2 and 0.00133Nm -2 ; e. heating said at least one bond coated part within said preheat chamber to a temperature in the range of 982°C - 1093°C; f. flowing carbon dioxide into the preheat chamber at a flow rate in the range of 50sccm - 500sccm while maintaining a pressure in the range of 1.33Nm -2 - 0.00133Nm -2 causing a thermally grown oxide layer to form; g. moving said at least one bond coated part with said thermally grown oxide layer to a coating chamber; wherein the flowing step occurs after the temperature of said at least one bond coated part has reached 1000°C; and wherein, during the heating step, the protective atmosphere becomes an equilibrium mixture of carbon monoxide/carbon dioxide of a ratio of greater than 10,000; and wherein said thermally grown oxide layer comprises an alpha alumina thermally grown oxide layer and wherein said bond coated part comprises a bond coat comprising MCrAlY; wherein MCrAlY is NiCrAlY or CoCrAlY. a. loading at least one bond coated part into a load chamber; b. moving the at least one bond coated part from the load chamber to a preheat chamber; c. backfilling said preheat chamber with a protective atmosphere of carbon dioxide; d. reducing the pressure in the preheat chamber to in the range of 1.33Nm -2 and 0.00133Nm -2 ; e. heating said at least one bond coated part within said preheat chamber to a temperature in the range of 982°C - 1093°C; f. flowing carbon dioxide into the preheat chamber at a flow rate in the range of 50sccm - 500sccm while maintaining a pressure in the range of 1.33Nm -2 - 0.00133Nm -2 causing a thermally grown oxide layer to form; g. moving said at least one bond coated part with said thermally grown oxide layer to a coating chamber;
A medium ejection apparatus comprising: a placement mount on which media (M) are placed; a restriction part that moves between a restriction position (P2) at which the restriction part restricts media (M) ejected toward the placement mount and a retracted position (P1) retracted from the restriction position (P2); and a restriction driver that drives the restriction part , characterized in that the medium ejection apparatus further comprises a control unit that controls the restriction part by adjusting a restriction frequency on the basis of an amount of heat generation of the restriction driver and at least either an amount of movement of the restriction part from the retracted position (P1) to the restriction position (P2) or ejection intervals at which the media (M) are ejected toward the placement mount , the restriction frequency being a frequency with which the restriction part performs a restriction operation for the media (M). a placement mount on which media (M) are placed; a restriction part that moves between a restriction position (P2) at which the restriction part restricts media (M) ejected toward the placement mount and a retracted position (P1) retracted from the restriction position (P2); and a restriction driver that drives the restriction part , characterized in that the medium ejection apparatus further comprises a control unit that controls the restriction part by adjusting a restriction frequency on the basis of an amount of heat generation of the restriction driver and at least either an amount of movement of the restriction part from the retracted position (P1) to the restriction position (P2) or ejection intervals at which the media (M) are ejected toward the placement mount , the restriction frequency being a frequency with which the restriction part performs a restriction operation for the media (M).
A method of wireless communication performed by a user equipment, UE, the method comprising: determining to perform a beam pair refinement procedure with regard to the UE and a base station; and transmitting , to the base station, information regarding performing the beam pair refinement procedure, wherein the information identifies a length of a waveform of the beam pair refinement procedure, which is sufficient to allow the beam pair refinement procedure to be performed, characterized by that the length is determined by the UE based on a path loss between the UE and the base station and a beam switching speed of the UE. determining to perform a beam pair refinement procedure with regard to the UE and a base station; and transmitting , to the base station, information regarding performing the beam pair refinement procedure, wherein the information identifies a length of a waveform of the beam pair refinement procedure, which is sufficient to allow the beam pair refinement procedure to be performed, characterized by that the length is determined by the UE based on a path loss between the UE and the base station and a beam switching speed of the UE.
An open wedge implant for open wedge osteotomies, comprising: a wedge body comprising a first expandable portion and a second expandable portion connected together by way of an intervening distal attachment; an expander configured to separate the first and second expandable portions so as to increase a proximal thickness and a wedge angle of the wedge body , the expander having a recess configured to loosely retain a smooth portion of a proximal screw; a first and second taper located on the expander ; and the proximal screw configured to move the expander within the wedge body . a wedge body comprising a first expandable portion and a second expandable portion connected together by way of an intervening distal attachment; an expander configured to separate the first and second expandable portions so as to increase a proximal thickness and a wedge angle of the wedge body , the expander having a recess configured to loosely retain a smooth portion of a proximal screw; a first and second taper located on the expander ; and the proximal screw configured to move the expander within the wedge body .
A compound having one the following structures, its individual diastereoisomers, its hydrates, its solvates, its crystal forms, its individual tautomers or a pharmaceutically acceptable salt thereof:
A computer-implemented method for processing a 4D seismic signal relative to a subsoil, the 4D seismic signal representing evolution throughout the period of 3D seismic signals corresponding to one or more of seismic attributes, the subsoil including a zone subject to extraction and/or injection, the method comprising: - providing the 4D seismic signal; - identifying a part of the 4D seismic signal corresponding to a zone of the subsoil distinct from the zone subject to extraction and/or injection and for which there is no evolution of the 3D seismic signals significantly distinct from noise; - determining a noise model of the 4D seismic signal based on the identified part of the 4D seismic signal, including interpreting seismic attribute evolution in the identified part of the 4D seismic signal as being noise; and - processing the 4D seismic signal based on the noise model. - providing the 4D seismic signal; - identifying a part of the 4D seismic signal corresponding to a zone of the subsoil distinct from the zone subject to extraction and/or injection and for which there is no evolution of the 3D seismic signals significantly distinct from noise; - determining a noise model of the 4D seismic signal based on the identified part of the 4D seismic signal, including interpreting seismic attribute evolution in the identified part of the 4D seismic signal as being noise; and - processing the 4D seismic signal based on the noise model.
A pharmaceutical composition for use in the treatment of hemophilia A characterized by an inversion of exons 1-22 in a Factor VIII gene, said pharmaceutical composition comprising a pharmaceutically acceptable carrier and a nucleic acid encoding an engineered nuclease, wherein said engineered nuclease is expressed in vivo, wherein said engineered nuclease has specificity for a recognition sequence positioned within an int22h-1 sequence of said Factor VIII gene, wherein said int22h-1 sequence of said Factor VIII gene has at least 95% sequence identity to SEQ ID NO: 3 or SEQ ID NO: 4, wherein said recognition sequence is within an F8A1 coding sequence that has at least 95% sequence identity to SEQ ID NO: 5 or SEQ ID NO: 6, and wherein said engineered nuclease is an engineered meganuclease, a TALEN, a zinc finger nuclease, a compact TALEN, a CRISPR, or a megaTAL.
Sealing ring which, as viewed in cross section, is designed in the shape of a 7, comprising a first axial limb and a sealing limb with a sealing lip , wherein the sealing limb is connected by means of a first joint to a first end face of the first axial limb , wherein the sealing limb on its side axially facing towards the first end face has a dirt guard lip with at least one sealing edge and a radially inner first boundary surface and a radially outer second boundary surface , wherein the sealing limb and the dirt guard lip delimit a substantially right angle radially on the inside and radially on the outside in the production-induced state of the sealing ring, the sealing lip has a first diameter and the sealing edge has a second diameter , and wherein the first diameter is smaller than the second diameter , characterized in that the first boundary surface delimiting the right angle radially on the inside of the dirt guard lip has a first length and a third boundary surface of the sealing limb has a third length which differs from the first length , and in that the first length is greater than the third length .
Sensor arrangement for determining a moisture content of a fluid medium flowing in a main flow direction , in particular intake air of an internal combustion engine, wherein the sensor arrangement has a sensor housing , in particular a plug-in sensor which is introduced or is able to be introduced into a flow tube, has at least one moisture sensor which is arranged in the sensor housing and which serves for determining the moisture content of the fluid medium, and has at least one retention element , wherein the retention element is at least partially permeable to moisture, wherein the sensor arrangement has an inlet opening for moisture into the sensor housing , and the moisture sensor and the retention element are arranged in the sensor housing in such a way that the moisture sensor is able to be subjected to moisture via the inlet opening and the retention element , wherein the sensor arrangement has at least one outlet opening for moisture from the sensor housing into the flowing fluid medium, which at least one outlet opening is arranged separately from the inlet opening , characterized in that the sensor housing is formed in such a way that the fluid medium flows more rapidly in the region of the outlet opening than in the region of the inlet opening , wherein the sensor housing has substantially the shape of an aerofoil-type profile, wherein the inlet opening and the outlet opening are arranged on a top side of the aerofoil-type profile.
An injection stretch blow moulded article (ISBM) comprising: (I) a polypropylene copolymer composition having an ethylene content of 2.0 to 5.0 wt%; and a crystallisation temperature (Tc) of at least 90°C when subjected to a cooling rate of 10 K/s; a crystallisation temperature (Tc) of at least 55°C when subjected to a cooling rate of 100 K/s; and a crystallisation temperature (Tc) of at least 40°C when subjected to a cooling rate of 300 K/s; and (II) optionally at least one nucleating agent; wherein the polypropylene copolymer composition comprises: 40 to 59 wt% of a first homopolymer fraction or first propylene copolymer fraction of propylene and one or more comonomers selected from ethylene and C4-C10 alpha-olefins said first fraction having a comonomer content of 0.0 to 1.8 wt%, and 60 to 41 wt% of a second propylene copolymer fraction. (I) a polypropylene copolymer composition having an ethylene content of 2.0 to 5.0 wt%; and a crystallisation temperature (Tc) of at least 90°C when subjected to a cooling rate of 10 K/s; a crystallisation temperature (Tc) of at least 55°C when subjected to a cooling rate of 100 K/s; and a crystallisation temperature (Tc) of at least 40°C when subjected to a cooling rate of 300 K/s; and (II) optionally at least one nucleating agent; wherein the polypropylene copolymer composition comprises: 40 to 59 wt% of a first homopolymer fraction or first propylene copolymer fraction of propylene and one or more comonomers selected from ethylene and C4-C10 alpha-olefins said first fraction having a comonomer content of 0.0 to 1.8 wt%, and 60 to 41 wt% of a second propylene copolymer fraction. a crystallisation temperature (Tc) of at least 90°C when subjected to a cooling rate of 10 K/s; a crystallisation temperature (Tc) of at least 55°C when subjected to a cooling rate of 100 K/s; and a crystallisation temperature (Tc) of at least 40°C when subjected to a cooling rate of 300 K/s; and (II) optionally at least one nucleating agent; 40 to 59 wt% of a first homopolymer fraction or first propylene copolymer fraction of propylene and one or more comonomers selected from ethylene and C4-C10 alpha-olefins said first fraction having a comonomer content of 0.0 to 1.8 wt%, and 60 to 41 wt% of a second propylene copolymer fraction.