A method of measuring an analyte using a micro biosensor for prolonging a usage lifetime of the micro biosensor implanted subcutaneously to measure a physiological signal representative of a physiological parameter associated with the analyte in a biofluid, the micro biosensor comprising a working electrode and a counter electrode , the working electrode being at least partially covered by a chemical reagent , the counter electrode including a silver and a silver halide having an initial amount, characterised by that the method comprising cyclic steps of: applying a measurement voltage to drive the working electrode to measure the physiological signal, thereby obtaining the physiological parameter, where the silver halide is consumed by a consumption amount, calculating the consumption amount of the silver halide being consumed from the counter electrode by calculating an area under the current curve of the physiological signal during a measurement period, stopping applying the measurement voltage, whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode to cause an oxidation reaction thereby the silver halide of a replenishment amount being replenished to the counter electrode, calculating the replenishment amount of the silver halide being replenished to the counter electrode by calculating an area under the current curve of the counter electrode during a replenishment period, wherein a guarding value of a sum of the calculated replenishment amount and the initial amount subtracting the calculated consumption amount is controlled within a range of the initial amount plus or minus a specific value, wherein the replenishment voltage has a constant voltage value and the replenishment time period is dynamically adjusted based on the calculated consumption amount of the silver halide or the replenishment time period has a constant time value and the replenishment voltage has a value dynamically adjusted based on the calculated consumption amount of the silver halide to make the calculated replenishment amount close to the calculated consumption amount or within a certain range of the calculated consumption amount. applying a measurement voltage to drive the working electrode to measure the physiological signal, thereby obtaining the physiological parameter, where the silver halide is consumed by a consumption amount, calculating the consumption amount of the silver halide being consumed from the counter electrode by calculating an area under the current curve of the physiological signal during a measurement period, stopping applying the measurement voltage, whenever the physiological parameter is obtained, applying a replenishment voltage to drive the counter electrode to cause an oxidation reaction thereby the silver halide of a replenishment amount being replenished to the counter electrode, calculating the replenishment amount of the silver halide being replenished to the counter electrode by calculating an area under the current curve of the counter electrode during a replenishment period, wherein a guarding value of a sum of the calculated replenishment amount and the initial amount subtracting the calculated consumption amount is controlled within a range of the initial amount plus or minus a specific value, wherein the replenishment voltage has a constant voltage value and the replenishment time period is dynamically adjusted based on the calculated consumption amount of the silver halide or the replenishment time period has a constant time value and the replenishment voltage has a value dynamically adjusted based on the calculated consumption amount of the silver halide to make the calculated replenishment amount close to the calculated consumption amount or within a certain range of the calculated consumption amount. <EOS>