A compound having the structure of Formula I: or a pharmaceutically acceptable salt thereof, wherein: A is selected from the group consisting of A1a, A1b, and A3a: or X is a (5-membered)heteroaryl wherein the heteroaryl is imidazolyl; R 1 is a (C 1 -C 6 )alkyl, wherein the alkyl is methyl; R 2a , R 2b , R 4a , R 4b , R 5a and R 5b are each independently: i) hydrogen; or ii) (C 1 -C 6 )alkyl, wherein the (C 1 -C 6 )alkyl is methyl; R 6 and R 7 are each independently hydrogen; z and y are each 1; ring B is optionally substituted with up to three R 10 , wherein each R 10 is independently selected from halogen or (C 1 -C 6 )alkyl; ring C is optionally substituted with up to three R 11 such that substitution occurs at any carbon atom that is chemically permissible, and wherein each R 11 is independently selected from halogen, (C 1 -C 6 )alkyl, or halo(C 1 -C 6 )alkyl; or two R 11 taken together with the carbon atom(s) to which they are attached form a (C 3 -C 6 )cycloalkyl or a (4- to 6-membered) heterocycloalkyl, wherein the (C 3 -C 6 )cycloalkyl and (4- to 6-membered) heterocycloalkyl moieties are each optionally substituted with one to three substituents independently selected from halogen or (C 1 -C 6 )alkyl; and ring D is optionally substituted with up to three R 12 , wherein each R 12 is independently selected from the group consisting of halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, -SF 5 , and (C 3 -C 6 )cycloalkyl, wherein the (C 3 -C 6 )cycloalkyl is optionally substituted with one to three substituents independently selected from halogen, (C 1 -C 6 )alkyl, or halo(C 1 -C 6 )alkyl. A is selected from the group consisting of A1a, A1b, and A3a: or X is a (5-membered)heteroaryl wherein the heteroaryl is imidazolyl; R 1 is a (C 1 -C 6 )alkyl, wherein the alkyl is methyl; R 2a , R 2b , R 4a , R 4b , R 5a and R 5b are each independently: i) hydrogen; or ii) (C 1 -C 6 )alkyl, wherein the (C 1 -C 6 )alkyl is methyl; i) hydrogen; or ii) (C 1 -C 6 )alkyl, wherein the (C 1 -C 6 )alkyl is methyl; R 6 and R 7 are each independently hydrogen; z and y are each 1; ring B is optionally substituted with up to three R 10 , wherein each R 10 is independently selected from halogen or (C 1 -C 6 )alkyl; ring C is optionally substituted with up to three R 11 such that substitution occurs at any carbon atom that is chemically permissible, and wherein each R 11 is independently selected from halogen, (C 1 -C 6 )alkyl, or halo(C 1 -C 6 )alkyl; or two R 11 taken together with the carbon atom(s) to which they are attached form a (C 3 -C 6 )cycloalkyl or a (4- to 6-membered) heterocycloalkyl, wherein the (C 3 -C 6 )cycloalkyl and (4- to 6-membered) heterocycloalkyl moieties are each optionally substituted with one to three substituents independently selected from halogen or (C 1 -C 6 )alkyl; and ring D is optionally substituted with up to three R 12 , wherein each R 12 is independently selected from the group consisting of halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, -SF 5 , and (C 3 -C 6 )cycloalkyl, wherein the (C 3 -C 6 )cycloalkyl is optionally substituted with one to three substituents independently selected from halogen, (C 1 -C 6 )alkyl, or halo(C 1 -C 6 )alkyl. <EOS>