mhurhangee/patent-ind-claim-en huggingface dataset:
A cyclic amine derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof for use in the treatment or prevention of a disease related to neuronal hyperexcitability selected from the group consisting of central nervous diseases selected from the group consisting of Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, schizophrenia, anxiety neurosis, bipolar disorder and epilepsy; spinal cord injury; disorders of memory; sequelae of intracerebral hemorrhage, cerebral infarction; and pruritus: wherein A represents a group represented by the following general formula (IIa), (IIb) or (IIc): wherein R 1 represents a hydroxyl group or a hydrogen atom, R 2 represents a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, a difluoromethyl group or a 2,2,2-trifluoroethyl group, R 3 represents a hydrogen atom, a fluorine atom, a bromine atom or a chlorine atom, each R 4 independently represents a methyl group or an ethyl group, n represents 1 or 2, and when R 1 represents a hydroxyl group, carbon marked with * represents asymmetric carbon.
A temperature sensor comprising a core having a length extending between a first end and a second end, the core having a cavity extending along the length, a wire extending in the cavity , along the length, the wire fixed at the first end and at the second end, the core having a transversal aperture at an intermediary location between the ends, the transversal aperture leading into the cavity , and a potting filling a portion of the cavity and supporting the wire at the intermediary location of the transversal aperture .
An inhibitor of Dynamin 2 for use in the treatment of Duchenne's muscular dystrophy, selected from the group consisting of: - an antibody directed against Dynamin 2, - a nucleic acid molecule interfering specifically with Dynamin 2 expression, - a nucleic acid or a nuclease engineered to target the DNM2 gene and to deliver nucleases using genome editing therapy, and - a small molecule inhibiting the Dynamin 2 activity, expression or function, said small molecule being selected from the group consisting of 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide, 3-Hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide, Tetradecyltrimethylammonium bromide, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid, 2-Cyano- N -octyl-3-[1-(3-dimethylaminopropyl)-1 H -indol-3-yl]acrylamide, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanylquinazolin-4 -one, N,N' -(Propane-1,3-diyl)bis(7,8-dihydroxy-2-imino-2 H -chromene-3-carboxamide), N,N' -(Ethane-1,2-diyl)bis(7,8-dihydroxy-2-imino-2 H -chromene-3-carboxamide), OctadecylTriMethylAmmonium Bromide, the Dynamin inhibitory peptide of amino acid sequence SEQ ID NO: 28, 3-Hydroxy- N' -[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide, and 4-(N,N-Dimethyl-N-octadecyl-N-ethyl)-4-aza-10-oxatricyclo-[5.2.1]decane-3,5-dione bromide. - an antibody directed against Dynamin 2, - a nucleic acid molecule interfering specifically with Dynamin 2 expression, - a nucleic acid or a nuclease engineered to target the DNM2 gene and to deliver nucleases using genome editing therapy, and - a small molecule inhibiting the Dynamin 2 activity, expression or function, said small molecule being selected from the group consisting of 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide, 3-Hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide, Tetradecyltrimethylammonium bromide, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid, 2-Cyano- N -octyl-3-[1-(3-dimethylaminopropyl)-1 H -indol-3-yl]acrylamide, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanylquinazolin-4 -one, N,N' -(Propane-1,3-diyl)bis(7,8-dihydroxy-2-imino-2 H -chromene-3-carboxamide), N,N' -(Ethane-1,2-diyl)bis(7,8-dihydroxy-2-imino-2 H -chromene-3-carboxamide), OctadecylTriMethylAmmonium Bromide, the Dynamin inhibitory peptide of amino acid sequence SEQ ID NO: 28, 3-Hydroxy- N' -[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide, and 4-(N,N-Dimethyl-N-octadecyl-N-ethyl)-4-aza-10-oxatricyclo-[5.2.1]decane-3,5-dione bromide.
A bi-parting door assembly with left and right door leaves for covering an aisle entrance between two rows of data center cabinets , comprising: a) a top rail assembly with a suspension and travel system for the door leaves, the suspension and travel system carrying all weight of the door leaves and allowing the door assembly to open and close; b) a left door leaf assembly being fastened to the top rail assembly and further having a brush seal and a guide rib and a front edge alignment feature attached thereto, wherein the brush seal comprises a brush seal mounted to a bottom of the left door leaf assembly and a brush seal mounted to a vertical back edge of the left door leaf assembly , and wherein the front edge alignment feature is attached to a leading edge of the left door leaf assembly ; c) a right door leaf assembly being fastened to the top rail assembly and further having a brush seal and a guide rib and a front edge alignment feature attached thereto, wherein the brush seal comprises a brush seal mounted to a bottom of the right door leaf assembly and a brush seal mounted to a vertical back edge of the right door leaf assembly , and wherein the front edge alignment feature , which is complementary with the front edge alignment feature on the left door leaf assembly , is attached to a leading edge of the right door leaf assembly ; d) lower guide channels behind each door leaf assembly for receiving their guide ribs ; and e) fasteners for holding the top rail assembly in a position over the aisle entrance . a) a top rail assembly with a suspension and travel system for the door leaves, the suspension and travel system carrying all weight of the door leaves and allowing the door assembly to open and close; b) a left door leaf assembly being fastened to the top rail assembly and further having a brush seal and a guide rib and a front edge alignment feature attached thereto, wherein the brush seal comprises a brush seal mounted to a bottom of the left door leaf assembly and a brush seal mounted to a vertical back edge of the left door leaf assembly , and wherein the front edge alignment feature is attached to a leading edge of the left door leaf assembly ; c) a right door leaf assembly being fastened to the top rail assembly and further having a brush seal and a guide rib and a front edge alignment feature attached thereto, wherein the brush seal comprises a brush seal mounted to a bottom of the right door leaf assembly and a brush seal mounted to a vertical back edge of the right door leaf assembly , and wherein the front edge alignment feature , which is complementary with the front edge alignment feature on the left door leaf assembly , is attached to a leading edge of the right door leaf assembly ; d) lower guide channels behind each door leaf assembly for receiving their guide ribs ; and e) fasteners for holding the top rail assembly in a position over the aisle entrance .
A surgical instrument , comprising: an end effector configured to grasp tissue, the end effector comprising: a jaw ; and a staple cartridge seatable in the jaw, wherein the staple cartridge comprises a sensor array ; a power source ; a transmission system configured to wirelessly transmit power from the power source to the staple cartridge to power the sensor array; characterised in that the surgical instrument further comprises a control circuit comprising a processor coupled to a memory circuit , the memory circuit having stored thereon machine executable instructions that, when executed by the processor, cause the processor to: monitor an efficiency of a transfer of the power from the surgical instrument to the staple cartridge; and adjust an operational parameter of the surgical instrument based on the efficiency of the transfer. an end effector configured to grasp tissue, the end effector comprising: a jaw ; and a staple cartridge seatable in the jaw, wherein the staple cartridge comprises a sensor array ; a jaw ; and a staple cartridge seatable in the jaw, wherein the staple cartridge comprises a sensor array ; a power source ; a transmission system configured to wirelessly transmit power from the power source to the staple cartridge to power the sensor array; characterised in that the surgical instrument further comprises a control circuit comprising a processor coupled to a memory circuit , the memory circuit having stored thereon machine executable instructions that, when executed by the processor, cause the processor to: monitor an efficiency of a transfer of the power from the surgical instrument to the staple cartridge; and adjust an operational parameter of the surgical instrument based on the efficiency of the transfer. monitor an efficiency of a transfer of the power from the surgical instrument to the staple cartridge; and adjust an operational parameter of the surgical instrument based on the efficiency of the transfer.
Piece of furniture comprising an electronic switching element for controlling a cabin function for an airliner, the piece of furniture having a structural layer and a translucent cover layer arranged above the structural layer , wherein the cover layer is continuous and planar, wherein the electronic switching element is in the form of a capacitive switching element and is surrounded by the structural layer underneath the cover layer , wherein the piece of furniture comprises a lighting means which is arranged above the capacitive switching element and underneath the cover layer , wherein the structural layer above the lighting means comprises one or more recesses .
An in vitro method for determining the risk of developing Alzheimer's disease or a cognitive disorder similar to said disease in a subject, which method comprises a) determining in a sample from the subject the level of phosphorylation in threonine residues in E2F4 protein and b) comparing the level of phosphorylation obtained in a) to a reference value, wherein an increase in the level of phosphorylation in threonine residues in E2F4 protein compared to a reference value is indicative that said subject has a high risk of developing Alzheimer's or a cognitive disorder similar to said disease, wherein the cognitive disorder similar to Alzheimer's disease is cognitive dysfunction syndrome of a dog. a) determining in a sample from the subject the level of phosphorylation in threonine residues in E2F4 protein and b) comparing the level of phosphorylation obtained in a) to a reference value,
A method for execution on the system of claim 9 of simulating an optical effect and/or characteristic of a selected ophthalmic lens design for a wearer , which characteristic has a bearing on the overall optical properties of the selected ophthalmic lens design or on an optical interaction between the selected ophthalmic lens design and the wearer, the method including: retrieving simulation information for the selected ophthalmic lens design, wherein the simulation information includes lens model information including a blur matrix and a distortion matrix for the selected ophthalmic lens design; and receiving input image information from a camera comprised in a head-mounted lens simulator unit worn by the wearer , wherein the head-mounted lens simulator unit further comprises a head movement/position sensor ; processing the input image information and the simulation information to generate output image data for an output image simulating the optical effect and/or characteristic of the selected ophthalmic lens design, wherein the output image is stabilised relative to head movements; and displaying, using the head-mounted lens simulator unit worn by the wearer , the output image for viewing by the wearer . retrieving simulation information for the selected ophthalmic lens design, wherein the simulation information includes lens model information including a blur matrix and a distortion matrix for the selected ophthalmic lens design; and receiving input image information from a camera comprised in a head-mounted lens simulator unit worn by the wearer , wherein the head-mounted lens simulator unit further comprises a head movement/position sensor ; processing the input image information and the simulation information to generate output image data for an output image simulating the optical effect and/or characteristic of the selected ophthalmic lens design, wherein the output image is stabilised relative to head movements; and displaying, using the head-mounted lens simulator unit worn by the wearer , the output image for viewing by the wearer .
A pesticide composition comprising at least one pesticidal active ingredient and at least one methylendioxyphenyl derivative compound of Formula (I) wherein R 1 is n- butyl or n-hexyl, wherein the at least one pesticide active principle is selected from the group consisting of: - a pyrethroid compound; - a juvenile hormone-like substance; - a neonicotinoid compound; - a carbamate compound; and - indoxacarb. - a pyrethroid compound; - a juvenile hormone-like substance; - a neonicotinoid compound; - a carbamate compound; and - indoxacarb.
A computer-implemented method for creating clean stratigraphic seismic traces , which comprises: a) selecting a first seismic trace beyond a seismic trace gap from a plurality of seismic traces collected parallel to a side of a seed fault ; b) calculating cross-correlation coefficients for the selected seismic trace with a next seismic trace for predetermined number of vertical shifts up and down; c) applying a parabolic curve fit to each cross-correlation coefficient to obtain a sub-sample shift between the selected seismic trace and the next seismic trace at the location of a peak of the parabolic curve fit, the value of the sub-sample shift being a score; d) accumulating the sub-sample shifts between the selected seismic trace and the next seismic trace; e) selecting the next seismic trace beyond the seismic trace gap from the plurality of collected seismic traces ; f) repeating steps b) through e) until the score is not greater than a predetermined threshold and there are no more seismic traces in the plurality of collected seismic traces ; g) extrapolating the accumulated sub-sample shifts across the seismic trace gap back to the seed fault to form a line or a surface; and h) calculating the clean stratigraphic seismic trace by stacking the plurality of collected seismic traces along the line or the surface on the side of the seed fault beyond the seismic trace gap ; and i) creating a wireline well log using the clean stratigraphic seismic trace , which has a lower signal-to-noise ratio than the plurality of seismic traces collected. a) selecting a first seismic trace beyond a seismic trace gap from a plurality of seismic traces collected parallel to a side of a seed fault ; b) calculating cross-correlation coefficients for the selected seismic trace with a next seismic trace for predetermined number of vertical shifts up and down; c) applying a parabolic curve fit to each cross-correlation coefficient to obtain a sub-sample shift between the selected seismic trace and the next seismic trace at the location of a peak of the parabolic curve fit, the value of the sub-sample shift being a score; d) accumulating the sub-sample shifts between the selected seismic trace and the next seismic trace; e) selecting the next seismic trace beyond the seismic trace gap from the plurality of collected seismic traces ; f) repeating steps b) through e) until the score is not greater than a predetermined threshold and there are no more seismic traces in the plurality of collected seismic traces ; g) extrapolating the accumulated sub-sample shifts across the seismic trace gap back to the seed fault to form a line or a surface; and h) calculating the clean stratigraphic seismic trace by stacking the plurality of collected seismic traces along the line or the surface on the side of the seed fault beyond the seismic trace gap ; and i) creating a wireline well log using the clean stratigraphic seismic trace , which has a lower signal-to-noise ratio than the plurality of seismic traces collected.
Use of an estolide ester compound as a replacement of silicone conditioning components in shampoo compositions, wherein the estolide ester compound has the Formula : wherein n is from 1 to 10, preferably from 2 to 8, in particular from 3 to 7, and R is selected from branched or linear C 3-20 -alkyl, preferably C 6-18 -alkyl, more preferably C 10-16 -alkyl, even more preferably C 12-14 -alkyl. n is from 1 to 10, preferably from 2 to 8, in particular from 3 to 7, and R is selected from branched or linear C 3-20 -alkyl, preferably C 6-18 -alkyl, more preferably C 10-16 -alkyl, even more preferably C 12-14 -alkyl.
An inflatable patient repositioning sheet comprising: an inflatable body ; a first air supply port and a second air supply port of the inflatable body ; a first air delivery sock and a second air delivery sock in the inflatable body , each air delivery sock having a first end portion and a second end portion, wherein the first end portion of each air delivery sock is in communication with one of the air supply ports and the second end portion is opposite the first end portion; at least one anchor member resisting movement of the second end portion of each air delivery sock toward the first end portion of the air delivery sock in response to air being supplied into the other of the air delivery socks and securing the second end portions of the air delivery socks to one another. an inflatable body ; a first air supply port and a second air supply port of the inflatable body ; a first air delivery sock and a second air delivery sock in the inflatable body , each air delivery sock having a first end portion and a second end portion, wherein the first end portion of each air delivery sock is in communication with one of the air supply ports and the second end portion is opposite the first end portion; at least one anchor member resisting movement of the second end portion of each air delivery sock toward the first end portion of the air delivery sock in response to air being supplied into the other of the air delivery socks and securing the second end portions of the air delivery socks to one another.
Method for producing a fluid line for a fluid, comprising a base body with at least one layer consisting of plastic, characterized in that at least one sheathing layer which is designed as a heat-protection layer is applied to the base body , wherein the sheathing layer has at least one heat-insulating layer and at least one metallic heat-conducting layer , wherein the heat-conducting layer comprises a plastic foil sheet wrapped around the base body and a metal layer applied to the plastic foil sheet before wrapping around the base body , or wherein the heat-conducting layer comprises at least one metal wire wrapped around the base body , wherein the at least one metal wire is provided with a coating before wrapping around the base body .
Self-compensating sleeper for supporting rails of a railroad track , comprising: a body having an upper surface configured for fixation of the rails , each at one or more rail seat areas by means of a rail fastening system, and a base configured to contact a ballast bed of granular material, wherein the body is configured to transfer the load from the rails to the ballast bed ; characterized in that the self-compensating sleeper further comprises one or more cavities penetrating the body between an upper opening in the upper surface and a lower opening in the base and configured to contain granular material for transfer of load to the ballast bed .
Coupling tool for connection to an outer end of a tubular element for the purpose of upending the element , wherein the coupling tool comprises engaging means for engaging the outer end of the element and a pivotable lifting member with which the coupling tool can be suspended from a lifting means such as a crane, wherein resilient arms are mounted on the coupling tool , characterized in that the resilient arms can be moved from a starting position to a position against a wall part of the outer end of the element for the purpose of aligning the suspended coupling tool relative to the outer end , wherein the arms can be arranged against an external wall part of the outer end of the element , and the arms are each mounted pivotally by means of a hinge on the coupling tool and can be rotated round the hinge using drive means .
A lithium secondary battery comprising: a positive electrode including a positive electrode active material containing lithium; a negative electrode including a negative electrode collector having a surface, on which a lithium metal is deposited in a charged state; a separator disposed between the positive electrode and the negative electrode; and a nonaqueous electrolyte solution filled between the positive electrode and the negative electrode , the nonaqueous electrolyte solution having a lithium ion conductivity, wherein the negative electrode collector includes projection portions projecting from the surface toward the separator , there is no projection portion on an imaginary line extending from a first end to a second end opposite to the first end of the surface of the negative electrode collector and traversing a space between the projection portions , wherein the projection portions are in direct contact with the separator while securing the space, in which the lithium metal is deposited in the charged state. a positive electrode including a positive electrode active material containing lithium; a negative electrode including a negative electrode collector having a surface, on which a lithium metal is deposited in a charged state; a separator disposed between the positive electrode and the negative electrode; and a nonaqueous electrolyte solution filled between the positive electrode and the negative electrode , the nonaqueous electrolyte solution having a lithium ion conductivity, wherein the negative electrode collector includes projection portions projecting from the surface toward the separator , there is no projection portion on an imaginary line extending from a first end to a second end opposite to the first end of the surface of the negative electrode collector and traversing a space between the projection portions , wherein the projection portions are in direct contact with the separator while securing the space, in which the lithium metal is deposited in the charged state.