A compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is H or -CH 3 ; R 2 is H or -CH 3 ; R 3 is H, -C 1 -C 5 alkyl, -OCH 3 , or -O-C 1 -C 3 haloalkyl; R 4 is H or -CH 3 ; moiety is R aa is H or -CH 3 ; R bb is H, -CH 3 or -CF 3 ; R cc is -CH 3 , -CD 3 or -CH 2 CF 3 ; moiety is E is N or CH; F is O, S, NH or NCH 3 ; R a is H or -CH 3 ; R b is H, D, -OH, F, -C 1 -C 5 alkyl, -CH 2 OCH 3 , -C 1 -C 5 haloalkyl, -NH 2 , cyclopropyl, or -CH 2 OH; R c is H, D or -CH 3 ; R d is H, -CN, -CF 3 , -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, -O-C 1 -C 3 alkyl, -N(R 6 )R 7 , wherein R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3 , -COCH 3 , -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R e is H, -CD 3 , Br, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, or -C 1 -C 5 alkyl substituted with 1 to 3 R g groups, wherein R g is -NH 2 , or F; R 10 is H orF; R 11 is H or F; R f is H, -CH 3 or R h is -CH 3 , -NH 2 or R i is H, -CH 3 , -CN, Br, R j is -NH 2 or R k is H, -CF 3 , I, Cl, Br, -CN, -C 1 -C 6 alkyl, R 12 is H or -CH 3 ; R 13 is H, -CH 3 , -CH 2 (C)(CH 3 ) 2 OH, -(CH 2 ) 3 CN, or -(CH 2 ) 2 NH 2 ; R 14 is H or -CH 3 ; R l is H, -C 1 -C 4 alkyl, -CF 3 , R m is H or -CH 3 ; R n is -NH 2 ; R o is H or -CH 3 ; R p is H or -CH 3 ; R q is H, -CN, F, Cl, -OCH 3 , -CF 3 , or -CH 3 ; and R s is -NH 2 or provided that when moiety is and each R 1 , R 2 , R 3 and R 4 is H, then moiety is R 1 is H or -CH 3 ; R 2 is H or -CH 3 ; R 3 is H, -C 1 -C 5 alkyl, -OCH 3 , or -O-C 1 -C 3 haloalkyl; R 4 is H or -CH 3 ; moiety is R aa is H or -CH 3 ; R bb is H, -CH 3 or -CF 3 ; R cc is -CH 3 , -CD 3 or -CH 2 CF 3 ; moiety is E is N or CH; F is O, S, NH or NCH 3 ; R a is H or -CH 3 ; R b is H, D, -OH, F, -C 1 -C 5 alkyl, -CH 2 OCH 3 , -C 1 -C 5 haloalkyl, -NH 2 , cyclopropyl, or -CH 2 OH; R c is H, D or -CH 3 ; R d is H, -CN, -CF 3 , -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, -O-C 1 -C 3 alkyl, -N(R 6 )R 7 , wherein R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3 , -COCH 3 , -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R 6 is H or -C 1 -C 3 alkyl; R 7 is H, -C 1 -C 3 alkyl, -SO 2 CH 3 , -COCH 3 , -C 1 -C 4 haloalkyl or -CH 2 CN, or R 6 and R 7 are taken together with the nitrogen to which they are attached to form the moiety wherein m is 0 or 1, and p is 0 or 1; R 8 is H, F or -C 1 -C 3 alkyl; R 9 is H, F or -C 1 -C 3 alkyl; R e is H, -CD 3 , Br, -C 1 -C 5 alkyl, -C 3 -C 6 cycloalkyl, or -C 1 -C 5 alkyl substituted with 1 to 3 R g groups, wherein R g is -NH 2 , or F; R 10 is H orF; R 11 is H or F; R 10 is H orF; R 11 is H or F; R f is H, -CH 3 or R h is -CH 3 , -NH 2 or R i is H, -CH 3 , -CN, Br, R j is -NH 2 or R k is H, -CF 3 , I, Cl, Br, -CN, -C 1 -C 6 alkyl, R 12 is H or -CH 3 ; R 13 is H, -CH 3 , -CH 2 (C)(CH 3 ) 2 OH, -(CH 2 ) 3 CN, or -(CH 2 ) 2 NH 2 ; R 14 is H or -CH 3 ; R 12 is H or -CH 3 ; R 13 is H, -CH 3 , -CH 2 (C)(CH 3 ) 2 OH, -(CH 2 ) 3 CN, or -(CH 2 ) 2 NH 2 ; R 14 is H or -CH 3 ; R l is H, -C 1 -C 4 alkyl, -CF 3 , R m is H or -CH 3 ; R n is -NH 2 ; R o is H or -CH 3 ; R p is H or -CH 3 ; R q is H, -CN, F, Cl, -OCH 3 , -CF 3 , or -CH 3 ; and R s is -NH 2 or provided that when moiety is and each R 1 , R 2 , R 3 and R 4 is H, then moiety is <EOS>