Method for manufacturing at least one orthodontic appliance intended to be worn by a patient, for the implementation, from an initial instant to a final instant, of a complex orthodontic treatment consisting of at least one first basic orthodontic treatment configured to change the morphology of the patient's head and at least one second basic orthodontic treatment configured to change the configuration of the patient's teeth, said method comprising the following steps: a) determination, preferably by means of a computer, of a regulation defining rules for the complex orthodontic treatment; then b) parameterization, by means of a computer, of said at least one first basic orthodontic treatment, then of said at least one second basic orthodontic treatment, in such a way that, after said parameterization, the complex orthodontic treatment still complies with said rules; c) design, by means of a computer, and manufacture of at least one orthodontic appliance adapted to said complex orthodontic treatment, the regulation defining at least one capital rule relating to the morphology of the head, at least one dental rule relating to the configuration of the teeth, and at least one transverse rule which is neither a capital rule nor a dental rule, the at least one capital rule concerning a value chosen from the group consisting of a height of the face at the final instant and a position of the lower lip and/or of the upper lip with respect to the chin and the forehead, the at least one transverse rule concerning a value chosen from the group consisting of - a cost for the complex orthodontic treatment, - a duration for the complex orthodontic treatment, - a pain coefficient for the complex orthodontic treatment, - a comfort coefficient for the complex orthodontic treatment, - one or more technical characteristics for said at least one orthodontic appliance. a) determination, preferably by means of a computer, of a regulation defining rules for the complex orthodontic treatment; then b) parameterization, by means of a computer, of said at least one first basic orthodontic treatment, then of said at least one second basic orthodontic treatment, in such a way that, after said parameterization, the complex orthodontic treatment still complies with said rules; c) design, by means of a computer, and manufacture of at least one orthodontic appliance adapted to said complex orthodontic treatment, the regulation defining at least one capital rule relating to the morphology of the head, at least one dental rule relating to the configuration of the teeth, and at least one transverse rule which is neither a capital rule nor a dental rule, the at least one capital rule concerning a value chosen from the group consisting of a height of the face at the final instant and a position of the lower lip and/or of the upper lip with respect to the chin and the forehead, the at least one transverse rule concerning a value chosen from the group consisting of - a cost for the complex orthodontic treatment, - a duration for the complex orthodontic treatment, - a pain coefficient for the complex orthodontic treatment, - a comfort coefficient for the complex orthodontic treatment, - one or more technical characteristics for said at least one orthodontic appliance. - a cost for the complex orthodontic treatment, - a duration for the complex orthodontic treatment, - a pain coefficient for the complex orthodontic treatment, - a comfort coefficient for the complex orthodontic treatment, - one or more technical characteristics for said at least one orthodontic appliance. <EOS>