Use of an aqueous composition for dissolving biomolecules selected from nucleic acids, preferably DNA, and proteins, from a tissue sample of an animal and for subsequent a) preserving said biomolecules or b) further processing said biomolecules, wherein said use comprises the steps: - sampling a tissue of an animal to produce a tissue sample of said animal and - immediately after sampling, exposing said tissue sample to an aqueous composition by contacting said sample with said composition for a defined period of time, said composition comprising - a buffer capable of buffering at a pH range from 7 to 9 at 25°C, optionally including a pH-setting agent, such as an acidifying agent or alkalizing agent, - a detergent - a salt at a concentration of 5-10 wt.% - a chelating agent, and water, - wherein said tissue of an animal is sampled using a tissue sampling tag, preferably ear tag, or a tissue sampling biopsy needle, and wherein said sample is contacted with said composition by introducing said sample into said composition, and wherein by exposing said sample to said composition, biomolecules selected from nucleic acids and proteins, from said tissue sample become dissolved in said aqueous composition to produce a biomolecule solution, - using said biomolecule solution for preserving said biomolecules or for further processing said biomolecules, such as detection of pathogen(s), e. g. BVDV, or genotyping, sequencing, hybridization analysis, or quantitative real-time PCR, or using said biomolecule solution for the detection of marker proteins, or marker nucleic acids, drugs, hormones or metabolites, - optionally using said aqueous composition to store said tissue sample for later use, wherein said aqueous composition does not contain a proteinase. a) preserving said biomolecules or b) further processing said biomolecules, - sampling a tissue of an animal to produce a tissue sample of said animal and - immediately after sampling, exposing said tissue sample to an aqueous composition by contacting said sample with said composition for a defined period of time, said composition comprising - a buffer capable of buffering at a pH range from 7 to 9 at 25°C, optionally including a pH-setting agent, such as an acidifying agent or alkalizing agent, - a detergent - a salt at a concentration of 5-10 wt.% - a chelating agent, and water, - a buffer capable of buffering at a pH range from 7 to 9 at 25°C, optionally including a pH-setting agent, such as an acidifying agent or alkalizing agent, - a detergent - a salt at a concentration of 5-10 wt.% - a chelating agent, and water, - wherein said tissue of an animal is sampled using a tissue sampling tag, preferably ear tag, or a tissue sampling biopsy needle, and wherein said sample is contacted with said composition by introducing said sample into said composition, and wherein by exposing said sample to said composition, biomolecules selected from nucleic acids and proteins, from said tissue sample become dissolved in said aqueous composition to produce a biomolecule solution, - using said biomolecule solution for preserving said biomolecules or for further processing said biomolecules, such as detection of pathogen(s), e. g. BVDV, or genotyping, sequencing, hybridization analysis, or quantitative real-time PCR, or using said biomolecule solution for the detection of marker proteins, or marker nucleic acids, drugs, hormones or metabolites, - optionally using said aqueous composition to store said tissue sample for later use, <EOS>