mhurhangee/patent-ind-claim-en huggingface dataset:
Porcine pancreatic tissue or cells derived from an animal that lacks any expression of functional alpha 1,3 galactosyltransferase (GTKO) and that expresses at least one first transgene and at least one second transgene, wherein the at least one first transgene is a complement inhibitor and wherein the at least one second transgene is specifically expressed in pancreatic tissue and is selected from the group consisting of (i) an anticoagulant and (ii) an immunosuppressant, for use in a method for the treatment or prophylaxis of diabetes.
A laser welding method comprising: a first step of overlaying a first workpiece and a second workpiece in a first machining region; and a second step of irradiating the first workpiece and the second workpiece with a laser beam in the first machining region while the laser beam is moved in a spiral path, and the first workpiece and the second workpiece are melted by irradiation of the laser beam to form a liquid phase portion, characterized in that in the second step the laser beam is moved so that the liquid phase portion is not irradiated with the laser beam, and a moving speed of the laser beam is faster toward the outer side of the spiral path. a first step of overlaying a first workpiece and a second workpiece in a first machining region; and a second step of irradiating the first workpiece and the second workpiece with a laser beam in the first machining region while the laser beam is moved in a spiral path, and the first workpiece and the second workpiece are melted by irradiation of the laser beam to form a liquid phase portion, characterized in that in the second step the laser beam is moved so that the liquid phase portion is not irradiated with the laser beam, and a moving speed of the laser beam is faster toward the outer side of the spiral path.
A slat for the leading edge of an aircraft wing , the slat including two or more slat tracks that in use dictate the path of movement of the slat as it moves from a retracted positon to a fully deployed position, each slat track having a shape that follows a helical path, wherein the slat includes an aerofoil surface supported by the two or more slat tracks, the slat being so configured that each slat track has at least two external surfaces which are on opposite sides of the slat track when viewed in cross-section and wherein the two external surfaces are defined by the two surfaces swept out by two notional fixed shape lines when moved along the helical path relative to the aerofoil surface of the slat. the slat includes an aerofoil surface supported by the two or more slat tracks, the slat being so configured that each slat track has at least two external surfaces which are on opposite sides of the slat track when viewed in cross-section and wherein the two external surfaces are defined by the two surfaces swept out by two notional fixed shape lines when moved along the helical path relative to the aerofoil surface of the slat.
Device for adjusting the bearing play of components that are mounted such that they can rotate coaxially in relation to one another and that are rotatably connected to each other by two axially spaced roller bearings , whereby one component is contained in a receptacle, for example a housing, frame, vehicle frame or vehicle fork and whereby the device is in operative connection with one end surface coaxially to one of the two roller bearings and exerts an axial pressure on one of the roller bearings , whereby - the device consists of two rings that are arranged coaxially next to one another on the component connected to the receptacle, the end surfaces facing towards one another of such rings each have at least one contour projecting out of the plane of the end surfaces and at least one of the contours has a slope, on which at least one opposing contour slides, and - means for mutual radial rotation on both rings , as a result of which one ring always moves axially in the direction of the roller bearing , and means for locking of the axially moving ring in the occupied axial position are provided, whereby as means of rotating the one ring has a locking element projecting axially out of the end surface of the one ring and the other ring has a recess into which the locking element projects, whereby the recess is widened in the peripheral direction of the ring and a positioning element which can be moved and locked against the locking element projects substantially tangentially to slightly obliquely into this recess , characterised in, that the ring facing away from the roller bearing in the mounted condition is arranged to be axially moveable on the component connected to the receptacle and is with its other end surface adjacent to the receptacle of this component, whereby the receptacle forms an abutment for this ring . - the device consists of two rings that are arranged coaxially next to one another on the component connected to the receptacle, the end surfaces facing towards one another of such rings each have at least one contour projecting out of the plane of the end surfaces and at least one of the contours has a slope, on which at least one opposing contour slides, and - means for mutual radial rotation on both rings , as a result of which one ring always moves axially in the direction of the roller bearing , and means for locking of the axially moving ring in the occupied axial position are provided, whereby as means of rotating the one ring has a locking element projecting axially out of the end surface of the one ring and the other ring has a recess into which the locking element projects, whereby the recess is widened in the peripheral direction of the ring and a positioning element which can be moved and locked against the locking element projects substantially tangentially to slightly obliquely into this recess ,
A modified oligonucleotide for use in a method of treating Alport Syndrome comprising administering to a subject having or suspected of having Alport Syndrome the modified oligonucleotide, wherein the modified oligonucleotide has the structure 5'-A E C S ATC S AGTC S TGAU S AAGC S TA E -3', (SEQ ID NO: 5), wherein nucleosides not followed by a subscript are β-D-deoxyribonucleosides; nucleosides followed by a subscript "E" are 2'-MOE nucleosides; nucleosides followed by a subscript "S" are S-cEt nucleosides; and each internucleoside linkage of the modified oligonucleotide is a phosphorothioate internucleoside linkage; wherein the administration comprises administering a pharmaceutical composition comprising the modified oligonucleotide at a dose of 110 mg.
A floor cleaner comprising: an inlet ; an outlet; a suction source operable to generate a suction airflow through the inlet and the outlet; a fluid flow path extending from the inlet to the outlet; a recovery tank positioned in the fluid flow path and including a recovery tank inlet and a recovery tank outlet ; and a float that obstructs the recovery tank outlet in a closed position of the float in response to a fluid level in the recovery tank, characterized in that the float includes an indicator visible when the float is in the closed position to indicate to the user that the float is in the closed position. an inlet ; an outlet; a suction source operable to generate a suction airflow through the inlet and the outlet; a fluid flow path extending from the inlet to the outlet; a recovery tank positioned in the fluid flow path and including a recovery tank inlet and a recovery tank outlet ; and a float that obstructs the recovery tank outlet in a closed position of the float in response to a fluid level in the recovery tank, characterized in that the float includes an indicator visible when the float is in the closed position to indicate to the user that the float is in the closed position.
Procedure for detecting a complete or partial blockage of a measuring tube (A, B) of a vibronic-type transducer of a flowmeter , wherein medium flows through the transducer and wherein the transducer has at least two measuring tubes (A, B) which are switched in parallel in terms of flow and can be excited, during operation, to produce mechanical vibrations, wherein said procedure is characterized by the following steps: A) Supply of heat to a medium conducted in a first measuring tube (A) by means of at least one heating element or Evacuation of heat from a medium conducted in a first measuring tube by means of at least one cooling element; B) Measurement of a temperature by means of at least one temperature sensor , which is thermally coupled to the medium conducted in the first measuring tube (A); C) Determination of a first comparative variable, which is characteristic for the transport of heat through the medium in the first measuring tube (A), on the basis of the supply of heat or evacuation of heat and the temperature measurement, and comparison of same with a reference variable; D) Detection of a blockage of at least one measuring tube (A, B) of the transducer if the first comparative variable deviates from the reference variable by more than a limit value, characterized in that the first comparative variable is a flow rate through the first measuring tube (A) that is determined on the basis of the supply of heat or the evacuation of heat, as well as the temperature measurement, and in that the reference variable is a flow rate expected for the first measuring tube (A) that is determined on the basis of a mass flow rate through the flowmeter which is measured according to the Coriolis principle. A) Supply of heat to a medium conducted in a first measuring tube (A) by means of at least one heating element or Evacuation of heat from a medium conducted in a first measuring tube by means of at least one cooling element; B) Measurement of a temperature by means of at least one temperature sensor , which is thermally coupled to the medium conducted in the first measuring tube (A); C) Determination of a first comparative variable, which is characteristic for the transport of heat through the medium in the first measuring tube (A), on the basis of the supply of heat or evacuation of heat and the temperature measurement, and comparison of same with a reference variable; D) Detection of a blockage of at least one measuring tube (A, B) of the transducer if the first comparative variable deviates from the reference variable by more than a limit value,
A resin composition comprising: a polyarylene sulfide having a chlorine content of 300 ppm or less; a mercapto silane coupling agent; a hydrolysis resistant additive; and a filler; wherein the hydrolysis resistant additive is para-phenylene-diisocyanate.
A compound of Formula (IIa1) or Formula (IIIa1): or a free acid, free base, pharmaceutically acceptable salt, isotopologue, stereoisomer, racemate, enantiomer, diastereomer or tautomer thereof, wherein: R 1 is heterocyclyl selected from piperazinyl, 1,4-diazepanyl, 2,5-diazabicyclo[2.2.1]heptyl, and -2,5-diazabicyclo[2.2.1]heptyl, optionally substituted with one, two or three R 3 substituents and optionally with one additional R 4 substituent; or optionally substituted with one, two, three or four R 3 substituents; R 2 is heteroaryl selected from 1,3-thiazolyl, 1,3-benzothiazolyl, 1,3-benzoxazolyl, pyrazolo[1,5-a]pyridinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-a]pyrazinyl, and imidazo[2,1-b] thiazolyl, optionally substituted with one, two or three R 6 substituents; R 3 is, in each instance, independently selected from C 1-8 alkyl, halo-C 1-8 alkyl, C 1-8 alkoxy-carbonyl, and hydroxy-C 1-8 alkyl; R 4 is aryl-C 1-8 alkyl, wherein aryl is optionally substituted with one, two or three R 5 substituents; R 5 is hydroxy; and R 6 is, in each instance, independently selected from halogen, C 1-8 alkyl, and halo-C 1 - 8 alkyl; R a is hydrogen; and R b is hydrogen. R 1 is heterocyclyl selected from piperazinyl, 1,4-diazepanyl, 2,5-diazabicyclo[2.2.1]heptyl, and -2,5-diazabicyclo[2.2.1]heptyl, optionally substituted with one, two or three R 3 substituents and optionally with one additional R 4 substituent; or optionally substituted with one, two, three or four R 3 substituents; R 2 is heteroaryl selected from 1,3-thiazolyl, 1,3-benzothiazolyl, 1,3-benzoxazolyl, pyrazolo[1,5-a]pyridinyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-a]pyrimidinyl, imidazo[1,2-a]pyrazinyl, and imidazo[2,1-b] thiazolyl, optionally substituted with one, two or three R 6 substituents; R 3 is, in each instance, independently selected from C 1-8 alkyl, halo-C 1-8 alkyl, C 1-8 alkoxy-carbonyl, and hydroxy-C 1-8 alkyl; R 4 is aryl-C 1-8 alkyl, wherein aryl is optionally substituted with one, two or three R 5 substituents; R 5 is hydroxy; and R 6 is, in each instance, independently selected from halogen, C 1-8 alkyl, and halo-C 1 - 8 alkyl; R a is hydrogen; and R b is hydrogen.
A blade track apparatus for a gas turbine engine comprising: a blade track including a segment portion having a first surface and a second surface opposite the first surface, wherein the first surface is arcuate; a first attachment portion extending from the second surface, wherein a coupling region of the attachment portion has a dovetail shaped cross section; and a second attachment portion extending from the second surface, the second attachment portion having an open channel with a substantially C-shaped cross section, wherein the first and second attachment portions and the segment portion of the blade track is formed from a ceramic matrix composite material. a blade track including a segment portion having a first surface and a second surface opposite the first surface, wherein the first surface is arcuate; a first attachment portion extending from the second surface, wherein a coupling region of the attachment portion has a dovetail shaped cross section; and a second attachment portion extending from the second surface, the second attachment portion having an open channel with a substantially C-shaped cross section, wherein the first and second attachment portions and the segment portion of the blade track is formed from a ceramic matrix composite material.
Zero-point clamping system for tool machines, in particular for lathes and/or milling machines, wherein the zero-point clamping system has: - a clamping plate which is set up to be arranged stationarily in relation to the tool machine, - at least one clamping device for clamping workpieces, which is set up to be mounted on the clamping plate , and - a fixing mechanism (17, 17', 17") which is set up to reversibly releasably fix the clamping device on the clamping plate characterised in that - the clamping device has several mounting recesses , and the clamping plate has a plurality of mounting elements , which are set up to engage in the mounting recesses of the clamping device , and - the clamping device has the fixing mechanism (17, 17', 17"), wherein the fixing mechanism (17, 17', 17") is set up to reversibly releasably fix the mounting elements when they are in engagement with the corresponding mounting recesses . - a clamping plate which is set up to be arranged stationarily in relation to the tool machine, - at least one clamping device for clamping workpieces, which is set up to be mounted on the clamping plate , and - a fixing mechanism (17, 17', 17") which is set up to reversibly releasably fix the clamping device on the clamping plate characterised in that - the clamping device has several mounting recesses , and the clamping plate has a plurality of mounting elements , which are set up to engage in the mounting recesses of the clamping device , and - the clamping device has the fixing mechanism (17, 17', 17"), wherein the fixing mechanism (17, 17', 17") is set up to reversibly releasably fix the mounting elements when they are in engagement with the corresponding mounting recesses .
An isolated antibody antagonist, or fragment thereof that specifically binds Domain I (SEQ ID NO: 9) of human ST2L, comprising a heavy chain variable region (VH) and light chain variable region (VL), wherein: (a) the VH comprises SEQ ID NO: 191; and (b) the VL comprises SEQ ID NO: 209. (a) the VH comprises SEQ ID NO: 191; and (b) the VL comprises SEQ ID NO: 209.
A UWB pulse emitter comprising at least one H-bridge, said bridge having a first branch and a second branch in parallel, a first end common to the first and second branches being connected to a high voltage and a second end common to the first and second branches being connected to a low voltage, the first branch comprising a first midpoint and the second branch comprising a second midpoint , a UWB antenna being connected to the first midpoint and/or to the second midpoint, the first branch comprising a first switch between said first common end and the first midpoint as well as a second switch between the first midpoint and the second common end , the second branch comprising a first switch between said first common end and the second midpoint as well as a second switch between the second midpoint and the second common end, the first and second switches of a branch being in opposite switching states and the switching state of the first (resp. second) switch of the first branch being opposite to the switching state of the first (resp. second) switch of the second branch, each switch being switched at the same RF frequency giving the central frequency of the UWB pulses, the UWB pulse emitter comprising: - a first amplitude control module between a power supply terminal and the first common end, allowing varying said high voltage at the first common end, and/or - a second amplitude control module between the second common end and the ground, allowing varying said low voltage at the second common end; - a first envelope control module between the first switches and the midpoints of the two branches, intended to shape the envelope of the positive part of a UWB pulse by means of a first baseband signal; - a second envelope control module between the midpoints and the second switches of the two branches, intended to shape the envelope of the negative part of a UWB pulse by means of a second baseband signal. - a first amplitude control module between a power supply terminal and the first common end, allowing varying said high voltage at the first common end, and/or - a second amplitude control module between the second common end and the ground, allowing varying said low voltage at the second common end; - a first envelope control module between the first switches and the midpoints of the two branches, intended to shape the envelope of the positive part of a UWB pulse by means of a first baseband signal; - a second envelope control module between the midpoints and the second switches of the two branches, intended to shape the envelope of the negative part of a UWB pulse by means of a second baseband signal.
A polyester monolayer bottle for use in filling of a carbonated pasteurized product comprising - greater than 4 wt. % poly (meta-xylyleneadipamide), wherein the poly (meta-xylyleneadamide is both an oxygen scavenging component and a passive component, - at least one ionic compatibilizer comprising a copolyester containing a metal sulfoisophthalic acid group - and a transition metal catalyst, wherein the oxygen scavenging component limits oxygen ingress to 1 ppm or less when measured six months after filling, and the passive component limits the carbonation loss to less than 25% when measured six months after filing. - greater than 4 wt. % poly (meta-xylyleneadipamide), wherein the poly (meta-xylyleneadamide is both an oxygen scavenging component and a passive component, - at least one ionic compatibilizer comprising a copolyester containing a metal sulfoisophthalic acid group - and a transition metal catalyst,
A reinforced panel (1;10) for forming a roof covering comprising at least a first honeycomb-shaped plate of light-permeable plastic material and reinforcement means of said first honeycomb-shaped plate facing a lower surface of said plate , wherein said reinforcement means comprise a light-permeable homogeneous layer (A'); wherein said light-permeable homogeneous layer (A') comprises a sheet of light-permeable inorganic material and a continuous layer of retardant or intumescent expanding resin ; when the honeycomb-shaped plate of plastic material reaches, even if only locally, its softening or melting point due to combustion, said homogenous layer (A') defines a barrier for holding the melted parts of said honeycomb-shaped plate of plastic material; characterized in that at least a strap of intumescent material (2B;2C) is arranged at a peripheral portion of said reinforced panel and on a surface of said reinforced panel which is opposite to a surface of said homogeneous layer (A') facing the lower surface of said first honeycomb-shaped plate .
Discharge head for a massage applicator for discharging and massaging-in cream-like liquids, having the following features: a. the discharge head is formed for attachment to a liquid reservoir , and b. the discharge head has a base portion with a receptacle for positionally fixed coupling to an outlet portion of the liquid reservoir , and c. the discharge head has a massage portion which has a massage surface , wherein the massage surface is provided with a massage profile and is penetrated by at least one outlet opening , and d. the massage portion is attached movably with respect to the base portion between a proximal and a distal end position along a main direction of extent , and e. the discharge head has a pumping device with a volumetrically variable pump chamber , an inlet valve and an outlet valve , by means of which valves liquid can be conveyed out of the liquid reservoir to the outlet opening , wherein the pump chamber is delimited by a wall of the base portion and a wall of the movable massage portion , characterized by the following feature: f. the discharge head has a slotted-guide mechanism with a slotted-guide track and a slotted-guide slider , by way of which a guided movement of the massage portion with respect to the base portion in the superimposed direction of rotation and main direction of extent is enabled. a. the discharge head is formed for attachment to a liquid reservoir , and b. the discharge head has a base portion with a receptacle for positionally fixed coupling to an outlet portion of the liquid reservoir , and c. the discharge head has a massage portion which has a massage surface , wherein the massage surface is provided with a massage profile and is penetrated by at least one outlet opening , and d. the massage portion is attached movably with respect to the base portion between a proximal and a distal end position along a main direction of extent , and e. the discharge head has a pumping device with a volumetrically variable pump chamber , an inlet valve and an outlet valve , by means of which valves liquid can be conveyed out of the liquid reservoir to the outlet opening , wherein the pump chamber is delimited by a wall of the base portion and a wall of the movable massage portion , f. the discharge head has a slotted-guide mechanism with a slotted-guide track and a slotted-guide slider , by way of which a guided movement of the massage portion with respect to the base portion in the superimposed direction of rotation and main direction of extent is enabled.