mhurhangee/patent-ind-claim-en huggingface dataset:
A monovalent Fab' antibody fragment binding specifically to CD154 for use in a method for treating an autoimmune, inflammatory, neurodegenerative or neuromuscular disorder in a human subject, which method comprises: a) administering an initial loading dose of 20-60 mg/kg of said antibody fragment binding specifically to CD154 to a human subject in need of such treatment; and b) 2 weeks after the initial loading dose administering a further dose or doses of half of the initial loading dose with a frequency of once every other week of said antibody fragment binding specifically to CD154 to the subject in need of such treatment, wherein said antibody fragment has the light chain sequence shown in SEQ ID NO:9 and the heavy chain sequences shown in SEQ ID NO:10, and wherein said antibody fragment has i) a maleimide group covalently linked to a single thiol group in the modified hinge region; a lysine residue is covalently linked to the maleimide group; and ii) a methoxypoly(ethyleneglycol) polymer having a molecular weight of approximately 20 kDa is attached to each of the amine groups on the lysine residue. a) administering an initial loading dose of 20-60 mg/kg of said antibody fragment binding specifically to CD154 to a human subject in need of such treatment; and b) 2 weeks after the initial loading dose administering a further dose or doses of half of the initial loading dose with a frequency of once every other week of said antibody fragment binding specifically to CD154 to the subject in need of such treatment, wherein said antibody fragment has the light chain sequence shown in SEQ ID NO:9 and the heavy chain sequences shown in SEQ ID NO:10, and wherein said antibody fragment has i) a maleimide group covalently linked to a single thiol group in the modified hinge region; a lysine residue is covalently linked to the maleimide group; and ii) a methoxypoly(ethyleneglycol) polymer having a molecular weight of approximately 20 kDa is attached to each of the amine groups on the lysine residue. i) a maleimide group covalently linked to a single thiol group in the modified hinge region; a lysine residue is covalently linked to the maleimide group; and ii) a methoxypoly(ethyleneglycol) polymer having a molecular weight of approximately 20 kDa is attached to each of the amine groups on the lysine residue.
Vapour recovery system for recovering vapour coming from a vehicle tank comprising: - a valve configured for being positionable in a closed position, an open position creating a passageway with a first size, and one or more intermediate positions each creating a passageway with a size which is smaller than said first size; - an actuator configured for operating said valve ; - an electronic controller configured for controlling said actuator to position said valve in a sequence of positions over time, wherein said sequence comprises at least one of said one or more intermediate positions during a time period (T); wherein the valve is arranged in a line of the vapour recovery system between a vapour outlet of the vehicle tank and the atmosphere ; characterized in that said time period (T) is larger than 1 second, the actuator is a stepper-motor based linear actuator, and the controlling comprises selecting at least one intermediate position of said one or more intermediate positions, the selection consisting in selecting a number of steps to be set from a predetermined reference position. - a valve configured for being positionable in a closed position, an open position creating a passageway with a first size, and one or more intermediate positions each creating a passageway with a size which is smaller than said first size; - an actuator configured for operating said valve ; - an electronic controller configured for controlling said actuator to position said valve in a sequence of positions over time, wherein said sequence comprises at least one of said one or more intermediate positions during a time period (T); wherein the valve is arranged in a line of the vapour recovery system between a vapour outlet of the vehicle tank and the atmosphere ; characterized in that said time period (T) is larger than 1 second, the actuator is a stepper-motor based linear actuator, and the controlling comprises selecting at least one intermediate position of said one or more intermediate positions, the selection consisting in selecting a number of steps to be set from a predetermined reference position.
An anti-CTLA-4 antibody for use in the treatment of cancer in a subject, which treatment comprises inducing a breakthrough event in the subject by administering the anti-CTLA-4 antibody to the subject until observing the breakthrough event wherein the breakthrough event is a Grade 3 or 4 adverse event selected from the group consisting of diarrhea, enterocolitis, dermatitis, hypophysitis, rash, and pruritis, wherein the breakthrough event is induced by administering escalating doses of anti-CTLA-4 antibody or administering anti-CTLA-4 antibody at decreasing dosage intervals and wherein the anti-CTLA-4 antibody is a human monoclonal IgG kappa antibody comprising a heavy chain variable region having the amino acid sequence and a light chain variable region having the amino acid sequence
A method comprising: associating a first electrode and a second electrode with a first layer of material , wherein associating the first electrode and the second electrode with the first layer of material comprises: affixing one of the first electrode or the second electrode to the first layer of material ; and positioning the other of the first electrode or the second electrode such that the other of the first electrode or the second electrode is free to move relative to the first layer of material ; positioning a light source in electrical communication with the first electrode and the second electrode ; and processing an assembly comprising the first layer of material , the first electrode , the second electrode , and the light source to form a multilayer panel with an embedded light source , wherein processing the assembly includes curing the first layer of material. associating a first electrode and a second electrode with a first layer of material , wherein associating the first electrode and the second electrode with the first layer of material comprises: affixing one of the first electrode or the second electrode to the first layer of material ; and positioning the other of the first electrode or the second electrode such that the other of the first electrode or the second electrode is free to move relative to the first layer of material ; positioning a light source in electrical communication with the first electrode and the second electrode ; and processing an assembly comprising the first layer of material , the first electrode , the second electrode , and the light source to form a multilayer panel with an embedded light source , wherein processing the assembly includes curing the first layer of material.
A constant current driver , for use with a luminaire module , comprising an apparatus for controlling the constant current driver , the apparatus being configured to measure an output voltage of the constant current driver applied to the luminaire module , to determine whether the measured output voltage exceeds an operating range of a current control mode of the constant current driver , and to reduce the output current of the constant current driver if the measured output voltage exceeds the operating range, characterized in that the apparatus is configured to measure the output current of the constant current driver and to reduce the output current to the same value as consumed by the luminaire module if the measured output voltage exceeds the operating range.
A stackable transport and/or storage container made from plastic, comprising side walls , which are connected in an articulated manner to a bottom and which can be transferred into a transport position parallel to the bottom and into an upright storage position, wherein at least one side wall is equipped on its outer side with at least one label holder , characterized in that the label holder only has two lateral clamping webs , which detachably fix a label held therein only on its narrow sides.
A circuit comprising: an input node configured to receive a signal; an output node configured to be coupled to a load ; a first circuit coupled between the input node and the output node , the first circuit configured to receive the signal and drive the signal on the output node at a first voltage; an active device coupled to the output node ; a second circuit coupled to the active device and the input node ; the second circuit configured to receive the signal and to drive the signal to the active device at a second voltage; and a tap circuit configured to selectively apply a tap signal including a time-shifted version of the signal to the signal driven by the second circuit before the signal driven by the second circuit reaches the active device , wherein the first voltage is approximately equal to the second voltage when the tap signal is not selectively applied to the signal driven by the second circuit , characterized in that when the active device is driven by the second voltage, the output node is driven by the first circuit to have the first voltage and the first voltage is approximately equal to the second voltage, approximately all the current output by the first circuit onto the output node is driven to the load . an input node configured to receive a signal; an output node configured to be coupled to a load ; a first circuit coupled between the input node and the output node , the first circuit configured to receive the signal and drive the signal on the output node at a first voltage; an active device coupled to the output node ; a second circuit coupled to the active device and the input node ; the second circuit configured to receive the signal and to drive the signal to the active device at a second voltage; and a tap circuit configured to selectively apply a tap signal including a time-shifted version of the signal to the signal driven by the second circuit before the signal driven by the second circuit reaches the active device , wherein the first voltage is approximately equal to the second voltage when the tap signal is not selectively applied to the signal driven by the second circuit , characterized in that when the active device is driven by the second voltage, the output node is driven by the first circuit to have the first voltage and the first voltage is approximately equal to the second voltage, approximately all the current output by the first circuit onto the output node is driven to the load .
A delivery device for implanting a stented prosthetic heart valve , the device comprising: an outer sheath ; an inner shaft disposed within the outer sheath ; a deflection assembly attached to the inner shaft and including: a plurality of hinge segments including a proximal-most hinge segment and a distal-most hinge segment , a joiner hub connected to the inner shaft and interfacing with the proximal-most hinge segment , and a leading hub interfacing with the distal-most hinge segment ; and a support shaft attached to and extending distally from the leading hub ; wherein the delivery device is configured to provide a loaded state in which a stented prosthetic heart valve is compressed over the support shaft and retained within a capsule of the outer sheath ; and further wherein a hinge region of the deflection assembly is configured to be deflected by a user to change a spatial orientation of the support shaft relative to the inner shaft while the delivery device is in the loaded state. an outer sheath ; an inner shaft disposed within the outer sheath ; a deflection assembly attached to the inner shaft and including: a plurality of hinge segments including a proximal-most hinge segment and a distal-most hinge segment , a joiner hub connected to the inner shaft and interfacing with the proximal-most hinge segment , and a leading hub interfacing with the distal-most hinge segment ; and a support shaft attached to and extending distally from the leading hub ; wherein the delivery device is configured to provide a loaded state in which a stented prosthetic heart valve is compressed over the support shaft and retained within a capsule of the outer sheath ; and further wherein a hinge region of the deflection assembly is configured to be deflected by a user to change a spatial orientation of the support shaft relative to the inner shaft while the delivery device is in the loaded state. a plurality of hinge segments including a proximal-most hinge segment and a distal-most hinge segment , a joiner hub connected to the inner shaft and interfacing with the proximal-most hinge segment , and a leading hub interfacing with the distal-most hinge segment ; and a support shaft attached to and extending distally from the leading hub ; wherein the delivery device is configured to provide a loaded state in which a stented prosthetic heart valve is compressed over the support shaft and retained within a capsule of the outer sheath ; and further wherein a hinge region of the deflection assembly is configured to be deflected by a user to change a spatial orientation of the support shaft relative to the inner shaft while the delivery device is in the loaded state.
Device for receiving and/or conducting a liquid or gaseous medium, comprising a sensor component housing and a sensor component which is inserted in a sensor component housing , wherein the sensor component housing comprises at least one tube section having a tube wall with an opening , and - the tube section has a diameter (D) and also a first and a second end (12.1, 12.2); - the tube wall has a wall thickness in the range from 0.5 mm to 1 mm and the sensor component housing comprises a feedthrough for a sensor component, wherein the opening receives the feedthrough for the sensor component and the feedthrough comprises a glass or glass-ceramic material and a component as a reinforcing component made of a material which is suitable for stable and optimal bonding by glass using the glass or glass-ceramic material 42, wherein the component as a reinforcing component is connected to the tube wall by a soldered or welded joint, wherein - the first and/or the second end (12.1, 12.2) has sloping regions (14.1, 14.2) such that the diameter (D) tapers to a final diameter (DE) at the first and/or second end (12.1, 12.2) of the tube section; - the sloping regions are produced by a shaping process, in particular by compression; - the tube wall additionally has at least one thickened region (30.1, 30.2) produced by shaping; and - the sensor component is an inner tube for a capacitive measurement, and the reinforcing component provides the wall thickness necessary for bonding by glass in the area of the feedthrough for the sensor component. - the tube section has a diameter (D) and also a first and a second end (12.1, 12.2); - the tube wall has a wall thickness in the range from 0.5 mm to 1 mm and the sensor component housing comprises a feedthrough for a sensor component, wherein the opening receives the feedthrough for the sensor component and the feedthrough comprises a glass or glass-ceramic material and a component as a reinforcing component made of a material which is suitable for stable and optimal bonding by glass using the glass or glass-ceramic material 42, wherein the component as a reinforcing component is connected to the tube wall by a soldered or welded joint, wherein - the first and/or the second end (12.1, 12.2) has sloping regions (14.1, 14.2) such that the diameter (D) tapers to a final diameter (DE) at the first and/or second end (12.1, 12.2) of the tube section; - the sloping regions are produced by a shaping process, in particular by compression; - the tube wall additionally has at least one thickened region (30.1, 30.2) produced by shaping; and - the sensor component is an inner tube for a capacitive measurement, and
Kitchen arrangement consisting of a hob and at least one extractor hood , wherein the extractor hood is designed to extract air from a space above the hob and comprises a suction apparatus with at least one suction aperture and at least one suction fan , wherein the suction fan is arranged beneath the suction aperture and sucks air downwards via the suction aperture , wherein the extractor hood further has a ceiling fan unit which is arranged above the suction apparatus as well as having at least one fan and at least one air outlet opening in the underside of the ceiling fan unit , characterised in that a curtain of air (L) directed downwards is output by the ceiling fan unit , which curtain of air delimits the space beneath the ceiling fan unit on at least three sides, and the suction aperture extends along at least three edges of the hob .
A medical component comprising from 5 to 50 wt% of a polyurethane and from 50 to 95 wt% of a radiopacifier, based on the total weight of the medical component, wherein the medical component has a thickness of from 0.025 to 1 mm, and wherein the polyurethane comprises a backbone that comprises the reaction product of a diisocyanate, a polymeric aliphatic diol, and a chain extender, and wherein the polymeric aliphatic diol comprises a polysiloxane diol and a polycarbonate diol.
A furling and adjustment assembly for boats with stay-free sails, which comprises: - a hooking device , configured to be mated to a coupling for the sail (V) and to a tack sheet (SM), - an actuation pulley assembly , configured to be actuated by an actuation rope (CA) and functionally associated with the hooking device in order to transmit, by way of the latter, a furling/unfurling movement to the sail (V), characterized in that the hooking device and the actuation pulley assembly being configured to be mutually moved between a condition of mutual engagement and a condition of mutual disengagement, a fixed spatial position of the actuation pulley assembly remaining constant while the tack point of the sail is adjusted, the hooking device in turn comprising an upper hooking element and a lower hooking element , which are mutually coupled so as to form an idle rotary pair, the upper hooking element being configured to be mated to a coupling for the sail (V), the lower hooking element being configured to be mated to a tack sheet (SM) for the adjustment of the tack point of the sail, the tack sheet (SM) passing through the actuation pulley assembly . - a hooking device , configured to be mated to a coupling for the sail (V) and to a tack sheet (SM), - an actuation pulley assembly , configured to be actuated by an actuation rope (CA) and functionally associated with the hooking device in order to transmit, by way of the latter, a furling/unfurling movement to the sail (V),
Gap seal device, comprising a housing having a fluid-filled guiding chamber , a multi-part piston which can be moved translationally and/or rotationally in the guiding chamber , wherein the piston separates a high-pressure region from a low-pressure region of the guiding chamber , the piston forming an annular gap having a nominal gap width (S 0 ) with an inner wall delimiting the guiding chamber , characterized in that the piston comprises a stepped rod , a sleeve which is slipped over a stepped-down region of the rod and which has a blind hole , and a coupling , wherein at least one stiffness change is provided in the stepped-down region of the rod or a tube portion of the sleeve , wherein a gap width (Sv) of the annular gap which is reduced compared to the nominal gap width (S 0 ) can be set in a region radial to the stiffness change by means of stress-induced expansion of an outer diameter of the tube portion of the sleeve as a function of the set stressing force (F). a housing having a fluid-filled guiding chamber , a multi-part piston which can be moved translationally and/or rotationally in the guiding chamber , wherein the piston separates a high-pressure region from a low-pressure region of the guiding chamber , the piston forming an annular gap having a nominal gap width (S 0 ) with an inner wall delimiting the guiding chamber , characterized in that the piston comprises a stepped rod , a sleeve which is slipped over a stepped-down region of the rod and which has a blind hole , and a coupling , wherein at least one stiffness change is provided in the stepped-down region of the rod or a tube portion of the sleeve , wherein a gap width (Sv) of the annular gap which is reduced compared to the nominal gap width (S 0 ) can be set in a region radial to the stiffness change by means of stress-induced expansion of an outer diameter of the tube portion of the sleeve as a function of the set stressing force (F).
A silicon carbide semiconductor device, comprising: a silicon carbide layer of a first conductivity type ; a silicon carbide layer of a second conductivity type formed on the silicon carbide layer of the first conductivity type ; a gate trench formed to extend from a surface of the silicon carbide layer of the second conductivity type to such a depth that the gate trench reaches the silicon carbide layer of the first conductivity type ; a gate electrode provided in the gate trench with an insulating film interposed therebetween; protection trenches formed to extend from the surface of the silicon carbide layer of the second conductivity type to a depth greater than the depth of the gate trench ; and a first conductive member provided in the protection trenches , wherein a cell region in a horizontal plane includes both the gate trench and a protection trench that surrounds only a part of the gate trench in the horizontal plane, and a gate region in the horizontal plane includes a protection trench and in which a gate pad or a lead electrode connected to the gate pad is disposed, a second conductive member is provided above the gate trench in the cell region and in the gate region, wherein the second conductive member is disposed in an area other than above the protection trench disposed in the cell region and is disposed to extend from above the gate trench in the cell region to the gate region through a part of the cell region in which the protection trench is not provided. a silicon carbide layer of a first conductivity type ; a silicon carbide layer of a second conductivity type formed on the silicon carbide layer of the first conductivity type ; a gate trench formed to extend from a surface of the silicon carbide layer of the second conductivity type to such a depth that the gate trench reaches the silicon carbide layer of the first conductivity type ; a gate electrode provided in the gate trench with an insulating film interposed therebetween; protection trenches formed to extend from the surface of the silicon carbide layer of the second conductivity type to a depth greater than the depth of the gate trench ; and a first conductive member provided in the protection trenches , wherein a cell region in a horizontal plane includes both the gate trench and a protection trench that surrounds only a part of the gate trench in the horizontal plane, and a gate region in the horizontal plane includes a protection trench and in which a gate pad or a lead electrode connected to the gate pad is disposed, a second conductive member is provided above the gate trench in the cell region and in the gate region, wherein the second conductive member is disposed in an area other than above the protection trench disposed in the cell region and is disposed to extend from above the gate trench in the cell region to the gate region through a part of the cell region in which the protection trench is not provided.