A compound represented by structural formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein: A is a pyrimidinone optionally substituted with 1 to 2 groups of R 1 ; Y is pyrazolyl optionally substituted with 1 to 2 groups of R b ; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, and (CH 2 ) n C 6-10 aryl, said alkyl and aryl optionally substituted with one to three groups of R a ; R 2 is selected from the group consisting of -C(=O)-,and -C(R x R y )-; R x and RY are independently selected from the group consisting of H, (CH 2 ) n OR, C 1-6 alkyl, C(O)OR and N(R) 2 , said alkyl optionally substituted with one to three groups of R a ; or R x and RY can combine with the carbon atom to which they are attached to form a group selected from -C(=O)-, C 2-6 alkenyl, C 3-6 cycloalkyl and C 3-6 heterocyclyl; R represents H, or C 1-6 alkyl, R 3 is C 4-10 heterocyclyl or C 6-10 aryl, said heterocyclyl and aryl optionally substituted with one to three groups of R a ; or R 2 and R 3 can combine to form a C 3-10 heterocyclyl, said heterocyclyl optionally substituted with one to three groups of R a; R a is selected from the group consisting of H, halo, CN, C 1-6 alkyl, (CH 2 ) n OR, (O)pC 1-4 haloalkyl, C(O)OR, -O(CH 2 ) n N(R) 2 , (CHR) n N(R) 2 , NO 2 , SCF 3 , S(O) s CF 3 , S(O) s R, SF 5 , C 3-10 cycloalkyl, C 5-10 heterocyclyl, and C 6-10 aryl, said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with one to three groups of R b ; R b is selected from the group consisting of H, halo, C 1-6 alkyl, (CH 2 ) n OR, and (O) p C 1-4 haloalkyl; n represents 0, 1, 2, 3, or 4; s represents 0, 1, or 2; and p represents 0 or 1. A is a pyrimidinone optionally substituted with 1 to 2 groups of R 1 ; Y is pyrazolyl optionally substituted with 1 to 2 groups of R b ; R 1 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, and (CH 2 ) n C 6-10 aryl, said alkyl and aryl optionally substituted with one to three groups of R a ; R 2 is selected from the group consisting of -C(=O)-,and -C(R x R y )-; R x and RY are independently selected from the group consisting of H, (CH 2 ) n OR, C 1-6 alkyl, C(O)OR and N(R) 2 , said alkyl optionally substituted with one to three groups of R a ; or R x and RY can combine with the carbon atom to which they are attached to form a group selected from -C(=O)-, C 2-6 alkenyl, C 3-6 cycloalkyl and C 3-6 heterocyclyl; R represents H, or C 1-6 alkyl, R 3 is C 4-10 heterocyclyl or C 6-10 aryl, said heterocyclyl and aryl optionally substituted with one to three groups of R a ; or R 2 and R 3 can combine to form a C 3-10 heterocyclyl, said heterocyclyl optionally substituted with one to three groups of R a; R a is selected from the group consisting of H, halo, CN, C 1-6 alkyl, (CH 2 ) n OR, (O)pC 1-4 haloalkyl, C(O)OR, -O(CH 2 ) n N(R) 2 , (CHR) n N(R) 2 , NO 2 , SCF 3 , S(O) s CF 3 , S(O) s R, SF 5 , C 3-10 cycloalkyl, C 5-10 heterocyclyl, and C 6-10 aryl, said alkyl, cycloalkyl, heterocyclyl and aryl optionally substituted with one to three groups of R b ; R b is selected from the group consisting of H, halo, C 1-6 alkyl, (CH 2 ) n OR, and (O) p C 1-4 haloalkyl; n represents 0, 1, 2, 3, or 4; s represents 0, 1, or 2; and p represents 0 or 1. <EOS>