A medical device, comprising: a plurality of electrodes each configured to be electrically coupled in contact with a patient's tissue; and control circuitry configured to control stimulation circuitry to issue a stimulation waveform pursuant to a stimulation program, wherein the stimulation program comprises a first electrode configuration, wherein the first electrode configuration defines which of the plurality of electrodes should be active, whether each active electrode comprises an anode electrode or a cathode electrode , and a percentage of a first total anodic current for each active anode electrode and a percentage of a first cathodic current for each active cathode electrode , wherein the first electrode configuration is associated with a center point of stimulation (CPS) in a patient's tissue, determine a neural response to the stimulation waveform at at least one electrode of the plurality of electrodes and to determine at least one feature of the neural response, and based on the at least one feature, adjust the stimulation program so that it comprises a second electrode configuration different from the first electrode configuration, wherein the second electrode configuration is associated with a CPS in the patient's tissue that equals the CPS associated with the first electrode configuration. a plurality of electrodes each configured to be electrically coupled in contact with a patient's tissue; and control circuitry configured to control stimulation circuitry to issue a stimulation waveform pursuant to a stimulation program, wherein the stimulation program comprises a first electrode configuration, wherein the first electrode configuration defines which of the plurality of electrodes should be active, whether each active electrode comprises an anode electrode or a cathode electrode , and a percentage of a first total anodic current for each active anode electrode and a percentage of a first cathodic current for each active cathode electrode , wherein the first electrode configuration is associated with a center point of stimulation (CPS) in a patient's tissue, determine a neural response to the stimulation waveform at at least one electrode of the plurality of electrodes and to determine at least one feature of the neural response, and based on the at least one feature, adjust the stimulation program so that it comprises a second electrode configuration different from the first electrode configuration, wherein the second electrode configuration is associated with a CPS in the patient's tissue that equals the CPS associated with the first electrode configuration. control stimulation circuitry to issue a stimulation waveform pursuant to a stimulation program, wherein the stimulation program comprises a first electrode configuration, wherein the first electrode configuration defines which of the plurality of electrodes should be active, whether each active electrode comprises an anode electrode or a cathode electrode , and a percentage of a first total anodic current for each active anode electrode and a percentage of a first cathodic current for each active cathode electrode , wherein the first electrode configuration is associated with a center point of stimulation (CPS) in a patient's tissue, determine a neural response to the stimulation waveform at at least one electrode of the plurality of electrodes and to determine at least one feature of the neural response, and based on the at least one feature, adjust the stimulation program so that it comprises a second electrode configuration different from the first electrode configuration, wherein the second electrode configuration is associated with a CPS in the patient's tissue that equals the CPS associated with the first electrode configuration. <EOS>