Method for determining an operative shift configuration of a drive mechanism of a gearbox (G) of a saddle-ride type vehicle , wherein said drive mechanism includes a pedal shift lever and a quick-shifter device that connects, directly or indirectly, said pedal shift lever to said gearbox (G), wherein said quick-shifter device includes a rod and first sensor means (SM0, SM1-SM2) that detect the variation of the tension state of said rod following a gear shifting, wherein said method includes the steps of: A) acquiring a first signal (S0, S1) generated by said first sensor means (SM0, SM1, SM2) and indicative of the tension state of said rod determined following said gear shifting; B) determining, based on said first signal (S0, S1), whether said rod is in a traction tension state or in a compression tension state; C) acquiring at least a second signal (S2, S2', S3, S4, S5) generated by second sensor means (SM3, SM5, SM4, SM6, SM7) following a gear shifting by means of said pedal shift lever ; D) determining, based on said at least second signal (S2), the gear engaged following said gear shifting and/or the direction of said gear shifting; E) determining an operative shift configuration of said drive mechanism of said gearbox (G) selected from a standard operative shift configuration and a reverse operative shift configuration of said pedal shift lever , wherein said operative shift configuration is determined based on the combination between the tension state determined in the step B) and the gear engaged and/or the direction of said gear shifting determined in the step D); wherein in said standard operative shift configuration of the pedal shift lever a first gear is engaged through a counter-clockwise rotation of the pedal lever, while a second and subsequent gears are engaged through a clockwise rotation of the pedal lever, and wherein in said reverse operative shift configuration of the pedal shift lever a first gear is engaged through a clockwise rotation of the pedal lever, while a second and subsequent gears are engaged through a counter-clockwise rotation of the pedal lever. A) acquiring a first signal (S0, S1) generated by said first sensor means (SM0, SM1, SM2) and indicative of the tension state of said rod determined following said gear shifting; B) determining, based on said first signal (S0, S1), whether said rod is in a traction tension state or in a compression tension state; C) acquiring at least a second signal (S2, S2', S3, S4, S5) generated by second sensor means (SM3, SM5, SM4, SM6, SM7) following a gear shifting by means of said pedal shift lever ; D) determining, based on said at least second signal (S2), the gear engaged following said gear shifting and/or the direction of said gear shifting; E) determining an operative shift configuration of said drive mechanism of said gearbox (G) selected from a standard operative shift configuration and a reverse operative shift configuration of said pedal shift lever , wherein said operative shift configuration is determined based on the combination between the tension state determined in the step B) and the gear engaged and/or the direction of said gear shifting determined in the step D); <EOS>