mhurhangee/patent-ind-claim-en huggingface dataset:
A drive system for a hand-held device for locally piercing human or animal skin, with: - a drive means which is configured to provide a rotary drive movement; and - a conversion mechanism which is coupled to the drive means for tapping the rotary drive movement and is configured to provide a linear forwards and backwards movement emanating from the rotary drive movement, the conversion mechanism having: - a wobble plate assembly which is disposed on a bearing means ; - a wobble plate formed on the wobble plate assembly which, during operation, executes a wobbling motion due to the rotary drive movement; - a tap which is coupled to the wobble plate and is configured to provide the linear forwards and backwards movement for tapping by means of cooperation with the wobble plate ; and - an adjustment component which is coupled to the wobble plate assembly and is displaceably disposed in a manner such that in order to adjust a stroke of the linear forwards and backwards movement provided at the tap , an inclination of the wobble plate with respect to the longitudinal direction is variable by displacing the adjustment component ; characterized by a distal joint component which is received by the bearing means and is coupled to the wobble plate assembly via a rotary joint. - a drive means which is configured to provide a rotary drive movement; and - a conversion mechanism which is coupled to the drive means for tapping the rotary drive movement and is configured to provide a linear forwards and backwards movement emanating from the rotary drive movement, the conversion mechanism having: - a wobble plate assembly which is disposed on a bearing means ; - a wobble plate formed on the wobble plate assembly which, during operation, executes a wobbling motion due to the rotary drive movement; - a tap which is coupled to the wobble plate and is configured to provide the linear forwards and backwards movement for tapping by means of cooperation with the wobble plate ; and - an adjustment component which is coupled to the wobble plate assembly and is displaceably disposed in a manner such that in order to adjust a stroke of the linear forwards and backwards movement provided at the tap , an inclination of the wobble plate with respect to the longitudinal direction is variable by displacing the adjustment component ; - a wobble plate assembly which is disposed on a bearing means ; - a wobble plate formed on the wobble plate assembly which, during operation, executes a wobbling motion due to the rotary drive movement; - a tap which is coupled to the wobble plate and is configured to provide the linear forwards and backwards movement for tapping by means of cooperation with the wobble plate ; and - an adjustment component which is coupled to the wobble plate assembly and is displaceably disposed in a manner such that in order to adjust a stroke of the linear forwards and backwards movement provided at the tap , an inclination of the wobble plate with respect to the longitudinal direction is variable by displacing the adjustment component ;
A method of applying a one-component solvent-borne coating composition to a substrate utilizing a high transfer efficiency applicator to form a coating layer disposed on the substrate, said method comprising the steps of: providing the coating composition to the high transfer efficiency applicator; and applying the coating composition to the substrate through the high transfer efficiency applicator to form the coating layer on the substrate wherein a loss of volatiles after application through the high transfer efficiency applicator is less than about 0.5 weight percent based on a total weight of the coating composition, wherein the coating composition comprises: F. a resin comprising an acrylic, a polyester, or combinations thereof; G. a melamine cross-linker; H. an optional pigment; I. an organic solvent; and J. at least one polyurea crystal sag control agent that is the reaction product of an amine and an isocyanate, that has a melting point of from about 50°C to about 150°C, and that is present in an amount of from about 0.1 to about 4 weight percent based on a total weight of the coating composition; and wherein the coating composition has a wet film thickness of at least about 30 microns measured at about 45 degrees without visible sag. providing the coating composition to the high transfer efficiency applicator; and applying the coating composition to the substrate through the high transfer efficiency applicator to form the coating layer on the substrate wherein a loss of volatiles after application through the high transfer efficiency applicator is less than about 0.5 weight percent based on a total weight of the coating composition, wherein the coating composition comprises: F. a resin comprising an acrylic, a polyester, or combinations thereof; G. a melamine cross-linker; H. an optional pigment; I. an organic solvent; and J. at least one polyurea crystal sag control agent that is the reaction product of an amine and an isocyanate, that has a melting point of from about 50°C to about 150°C, and that is present in an amount of from about 0.1 to about 4 weight percent based on a total weight of the coating composition; and F. a resin comprising an acrylic, a polyester, or combinations thereof; G. a melamine cross-linker; H. an optional pigment; I. an organic solvent; and J. at least one polyurea crystal sag control agent that is the reaction product of an amine and an isocyanate, that has a melting point of from about 50°C to about 150°C, and that is present in an amount of from about 0.1 to about 4 weight percent based on a total weight of the coating composition; and wherein the coating composition has a wet film thickness of at least about 30 microns measured at about 45 degrees without visible sag.
A cable assembly , comprising: a connector head electrically coupled to a plurality of conductors disposed in a cable ; a metal shell encasing a portion of the connector head and a portion of the cable; a metal foil that wraps conformably around an exterior of the metal shell, wherein the metal foil covers substantially all of the exterior of the metal shell and extends beyond the metal shell (i) onto a grounding layer surrounding the plurality of conductors, and (ii) onto a portion of the connector head; and a solder layer disposed about the metal foil, wherein the solder layer bonds and electrically couples the metal foil (i) to the grounding layer, and (ii) to the connector head. a connector head electrically coupled to a plurality of conductors disposed in a cable ; a metal shell encasing a portion of the connector head and a portion of the cable; a metal foil that wraps conformably around an exterior of the metal shell, wherein the metal foil covers substantially all of the exterior of the metal shell and extends beyond the metal shell (i) onto a grounding layer surrounding the plurality of conductors, and (ii) onto a portion of the connector head; and a solder layer disposed about the metal foil, wherein the solder layer bonds and electrically couples the metal foil (i) to the grounding layer, and (ii) to the connector head.
A solid oral dosage form comprising a heat-labile gelling agent, wherein the heat-labile gelling agent is xanthan gum; a thermal stabilizer, wherein the thermal stabilizer is a carbomer homopolymer; a pH-modifying agent, wherein the pH-modifying agent is sodium bicarbonate; and a drug susceptible to abuse; the dosage form providing immediate release of the drug, wherein the dosage form releases at least about 85% of the drug within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml SGF at 37 °C.
An isolated humanized monoclonal antibody for use in treating or preventing cancer by inhibiting migration of regulatory T-cells, wherein the antibody binds to the human CC chemokine receptor 4 (CCR4), wherein the antibody has an IgG4 heavy chain constant region comprising SEQ ID NO: 6 or SEQ ID NO: 8, and wherein the antibody comprises: a. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 2 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 4; b. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 16 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 18; c. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 20 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 22; d. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 24 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 26; e. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 28 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 30; or f. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 44 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 46. a. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 2 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 4; b. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 16 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 18; c. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 20 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 22; d. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 24 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 26; e. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 28 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 30; or f. a variable heavy chain region (VH) comprising the amino acid sequence of SEQ ID NO: 44 and a variable light chain region (VL) comprising the amino acid sequence of SEQ ID NO: 46.
A structural assembly of an aircraft , comprising: a structural element constructed of a composite material comprising a matrix material and a plurality of fibers positioned to extend through the matrix material, wherein at least a portion of the plurality of fibers are accessible from a surface of the structural element; a fastener secures the structural element to a structural component ; and a metal structure positioned in contact with a surface of the fastener, wherein the metal structure extends from the surface of the fastener and contacts at least a portion of the at least a portion of the plurality of fibers, wherein the metal structure comprises a gallium alloy, wherein the metal structure is obtainable by: mixing a liquid metal alloy comprising gallium with at least one of a solid metal and solid metal alloy forming a slurry ; and applying the slurry onto a surface of a fastener and onto at least a portion of the at least a portion of the plurality of fibers. a structural element constructed of a composite material comprising a matrix material and a plurality of fibers positioned to extend through the matrix material, wherein at least a portion of the plurality of fibers are accessible from a surface of the structural element; a fastener secures the structural element to a structural component ; and a metal structure positioned in contact with a surface of the fastener, wherein the metal structure extends from the surface of the fastener and contacts at least a portion of the at least a portion of the plurality of fibers, wherein the metal structure comprises a gallium alloy, wherein the metal structure is obtainable by: mixing a liquid metal alloy comprising gallium with at least one of a solid metal and solid metal alloy forming a slurry ; and applying the slurry onto a surface of a fastener and onto at least a portion of the at least a portion of the plurality of fibers. mixing a liquid metal alloy comprising gallium with at least one of a solid metal and solid metal alloy forming a slurry ; and applying the slurry onto a surface of a fastener and onto at least a portion of the at least a portion of the plurality of fibers.
An apparatus comprising means for: determining , for an audio signal, if sound energy in at least one first direction is different to sound energy in at least one second direction by at least a threshold amount; and controlling , before an audio zoom function is selected, an amount of headroom provided in the audio signal so as to enable audio zooming at a later time when the zoom function is selected, based on whether or not sound energy in at least one first direction is different to the sound energy in at least one second direction by at least a threshold amount. determining , for an audio signal, if sound energy in at least one first direction is different to sound energy in at least one second direction by at least a threshold amount; and controlling , before an audio zoom function is selected, an amount of headroom provided in the audio signal so as to enable audio zooming at a later time when the zoom function is selected, based on whether or not sound energy in at least one first direction is different to the sound energy in at least one second direction by at least a threshold amount.
Process for producing hydrogen from a light hydrocarbon source, comprising at least: a. a step (a) of generating a synthesis gas by steam reforming of said light gaseous hydrocarbons, comprising at least a step (a1) of desulfurizing said hydrocarbons for reforming, an optional step of pre-reforming the desulfurized hydrocarbons, a step of steam-reforming the desulfurized and optionally pre-reformed hydrocarbons in tubular reactors installed in the furnace of a reformer heated by burners which are fed with fuel by at least secondary fuel gas, comprising some or all of the residual gas mixture produced in the hydrogen production step (b) of the process, and primary fuel gas, withdrawn preferably from the light gaseous hydrocarbon source, b. a step (b) of producing hydrogen from the synthesis gas generated in step (a), comprising at least a step (b1) of hydrogen-enriching the synthesis gas by conversion of carbon monoxide according to the exothermic conversion reaction CO + H 2 O → CO 2 + H 2 , a step (b2) of purifying the synthesis gas in a pressure swing adsorption unit to give a pure H 2 product and a residual gas mixture containing CH 4 , CO, H 2 and CO 2 , characterized in that the conversion reaction of step (b1) is carried out in a cooled conversion reactor in which some of the heat produced in step (b1) is transferred by indirect heat exchange in the reactor with a first gaseous fluid so as to preheat this fluid before it is used in the synthesis gas generation step (a), and in that the hydrogen-enriched synthesis gas leaving the conversion reactor is cooled by indirect heat exchange with a second gaseous fluid before it is used in step (a). a. a step (a) of generating a synthesis gas by steam reforming of said light gaseous hydrocarbons, comprising at least a step (a1) of desulfurizing said hydrocarbons for reforming, an optional step of pre-reforming the desulfurized hydrocarbons, a step of steam-reforming the desulfurized and optionally pre-reformed hydrocarbons in tubular reactors installed in the furnace of a reformer heated by burners which are fed with fuel by at least secondary fuel gas, comprising some or all of the residual gas mixture produced in the hydrogen production step (b) of the process, and primary fuel gas, withdrawn preferably from the light gaseous hydrocarbon source, b. a step (b) of producing hydrogen from the synthesis gas generated in step (a), comprising at least a step (b1) of hydrogen-enriching the synthesis gas by conversion of carbon monoxide according to the exothermic conversion reaction CO + H 2 O → CO 2 + H 2 , a step (b2) of purifying the synthesis gas in a pressure swing adsorption unit to give a pure H 2 product and a residual gas mixture containing CH 4 , CO, H 2 and CO 2 ,
An antagonist of mineralocorticoid receptor for use in the treatment of metabolic osteoarthritis in a subject in need thereof, wherein the antagonist of mineralocorticoid receptor is eplerenone.
A method of generating three-dimensional biological structures, the method comprising: (a) depositing, using a flow-confinement device, a first layer of a suspension in a pattern over a substrate, the suspension comprising a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (b') culturing the plurality of cells in the first layer for a period of time of between about 10 minutes and about 8 weeks, in order to establish or increase the amount of one or more selected from the group consisting of: cell-cell interactions, cell-cell attachments, cell mass, and cell quantity, the culturing resulting in a tissue-like structure; (c) depositing a cell-attachment agent over the first layer of attached cells; (d) depositing, using a flow-confinement device, a second layer of the suspension in a pattern over the cell-attachment agent; and (e) repeating steps (b)-(d) until a biological structure having a predefined thickness is generated, where steps a)-d) are not performed on the human or animal body. (a) depositing, using a flow-confinement device, a first layer of a suspension in a pattern over a substrate, the suspension comprising a liquid and a plurality of cells; (b) allowing the plurality of cells to attach to the substrate and form a first layer of attached cells; (b') culturing the plurality of cells in the first layer for a period of time of between about 10 minutes and about 8 weeks, in order to establish or increase the amount of one or more selected from the group consisting of: cell-cell interactions, cell-cell attachments, cell mass, and cell quantity, the culturing resulting in a tissue-like structure; (c) depositing a cell-attachment agent over the first layer of attached cells; (d) depositing, using a flow-confinement device, a second layer of the suspension in a pattern over the cell-attachment agent; and (e) repeating steps (b)-(d) until a biological structure having a predefined thickness is generated,
Monitoring method comprising: • integrally coupling a first electromagnetic mirror of passive type and a given target to be monitored, wherein said given target is not visible, or not always visible, or partially visible to synthetic aperture radar; • integrally coupling a second electromagnetic mirror of passive type and the given target , or installing the second electromagnetic mirror of passive type in a given fixed position in a given area of the earth's surface where the given target is located; and • monitoring over time the given target by - acquiring SAR images of the given area of the earth's surface at different times by means of one or more synthetic aperture radar(s) installed on board one or more satellites and/or one or more aerial platforms, - computing, by means of a processing unit, a respective distance between the first electromagnetic mirror and the second electromagnetic mirror in each acquired SAR image, and - determining, by means of the processing unit, a mutual displacement of the first and second electromagnetic mirrors on the basis of the computed distances between said first and second electromagnetic mirrors in the acquired SAR images; wherein no interferometric technique is used. • integrally coupling a first electromagnetic mirror of passive type and a given target to be monitored, wherein said given target is not visible, or not always visible, or partially visible to synthetic aperture radar; • integrally coupling a second electromagnetic mirror of passive type and the given target , or installing the second electromagnetic mirror of passive type in a given fixed position in a given area of the earth's surface where the given target is located; and • monitoring over time the given target by - acquiring SAR images of the given area of the earth's surface at different times by means of one or more synthetic aperture radar(s) installed on board one or more satellites and/or one or more aerial platforms, - computing, by means of a processing unit, a respective distance between the first electromagnetic mirror and the second electromagnetic mirror in each acquired SAR image, and - determining, by means of the processing unit, a mutual displacement of the first and second electromagnetic mirrors on the basis of the computed distances between said first and second electromagnetic mirrors in the acquired SAR images; wherein no interferometric technique is used. - acquiring SAR images of the given area of the earth's surface at different times by means of one or more synthetic aperture radar(s) installed on board one or more satellites and/or one or more aerial platforms, - computing, by means of a processing unit, a respective distance between the first electromagnetic mirror and the second electromagnetic mirror in each acquired SAR image, and - determining, by means of the processing unit, a mutual displacement of the first and second electromagnetic mirrors on the basis of the computed distances between said first and second electromagnetic mirrors in the acquired SAR images;
Intra-operative Radio Therapy (IORT) device for radiotherapy treatment of cancer patients, comprising a source of particles, an accelerating device which sends a beam of particles on a target through an applicator , a scattering filter which allows to maintain the distance between said source of particles and said target within a range compatible with the use of said IORT device in standard operating rooms and which allows to provide a maximum energy of 12 MeV, so as to allow a suitable treatment of the target , and an optical system for collimating said beam of particles which is placed between said scattering filter and said applicator , characterized in that said optical collimating system of said beam of particles comprises a primary screen , configured to shield the radiation produced by said scattering filter , a secondary screen configured to shield the photons produced on said primary screen , and a collimating apparatus , which provides for housing the monitor chambers .
A container comprising: a fire-retarding material ; a substantially airtight cavity formed by the fire-retarding material sized to hold at least one item ; a vacuum device connected to the substantially airtight cavity , configured to make the substantially airtight cavity substantially airtight; a reinforcement material connected with the fire-retarding material, a water-repelling material connected with the fire-retarding material , the water-repelling material covering the fire-retarding material and the reinforcement material ; and an exterior material disposed on an outside of the container , the exterior material covering the water-repelling material . a fire-retarding material ; a substantially airtight cavity formed by the fire-retarding material sized to hold at least one item ; a vacuum device connected to the substantially airtight cavity , configured to make the substantially airtight cavity substantially airtight; a reinforcement material connected with the fire-retarding material, a water-repelling material connected with the fire-retarding material , the water-repelling material covering the fire-retarding material and the reinforcement material ; and an exterior material disposed on an outside of the container , the exterior material covering the water-repelling material .