mhurhangee/patent-ind-claim-en huggingface dataset:
A method for refolding a denatured protein, comprising combining the denatured protein with a solubilization buffer that comprises a denaturing agent, to obtain a first protein composition comprising solubilized denatured protein, wherein the denatured protein comprises an Fc region and a fibronectin based scaffold domain; diafiltering the first protein composition comprising solubilized denatured protein with 2-4 diavolumes of a refold buffer which has a pH in the range of 9 to 11 to obtain a second protein composition comprising partially refolded protein; and incubating the second protein composition comprising partially refolded protein with a refold/oxidizing buffer which has a pH in the range of 9 to 11 to obtain a third protein composition comprising the protein in a refolded state, wherein the protein in the refolded state is a disulfide linked dimer. combining the denatured protein with a solubilization buffer that comprises a denaturing agent, to obtain a first protein composition comprising solubilized denatured protein, wherein the denatured protein comprises an Fc region and a fibronectin based scaffold domain; diafiltering the first protein composition comprising solubilized denatured protein with 2-4 diavolumes of a refold buffer which has a pH in the range of 9 to 11 to obtain a second protein composition comprising partially refolded protein; and incubating the second protein composition comprising partially refolded protein with a refold/oxidizing buffer which has a pH in the range of 9 to 11 to obtain a third protein composition comprising the protein in a refolded state, wherein the protein in the refolded state is a disulfide linked dimer.
Method for enrolling a device (IED) in a secure network to which an information system (IS) is connected, the method comprising the steps, implemented by a trusted device (HSACD) connected to the secure network, of: a) receiving (S1, S22) from a user terminal (J, TU), distinct from the device to be enrolled (IED), an authorization to connect to the device to be enrolled (IED), said authorization notifying the trusted device (HSACD) that the device to be enrolled (IED) is authorized to access the secure network and activating an enrolment mode of the trusted device (HSACD), b) in the enrolment mode, upon receiving the authorization to connect to the device to be enrolled (IED), generating (S3, S24) cryptographic keys intended for the device to be enrolled (IED) to access the secure network, and c) transmitting (S5, S26) the cryptographic keys to the device to be enrolled (IED), said cryptographic keys enabling the secure access of the device to be enrolled (IED) to the secure network. a) receiving (S1, S22) from a user terminal (J, TU), distinct from the device to be enrolled (IED), an authorization to connect to the device to be enrolled (IED), said authorization notifying the trusted device (HSACD) that the device to be enrolled (IED) is authorized to access the secure network and activating an enrolment mode of the trusted device (HSACD), b) in the enrolment mode, upon receiving the authorization to connect to the device to be enrolled (IED), generating (S3, S24) cryptographic keys intended for the device to be enrolled (IED) to access the secure network, and c) transmitting (S5, S26) the cryptographic keys to the device to be enrolled (IED), said cryptographic keys enabling the secure access of the device to be enrolled (IED) to the secure network.
Motor vehicle door latch, comprising a locking mechanism that substantially consists of a catch and a pawl , also comprising an electric drive for the locking mechanism , and comprising an actuating lever chain between the electric drive and the locking mechanism , a coupling element of the actuating lever chain being able to at least be decoupled by means of an emergency actuating element that can be acted on manually, the emergency actuating element acting on the coupling element predominantly linearly with respect to a slot ,characterized in that the emergency actuating element selectively engages with a pin of the coupling element that is guided in the slot , the slot being provided on a release lever .
A direct-current interrupting device comprising: a mechanical breaker ; wherein the mechanical breaker comprises: a mechanical contact made by connecting at least one high-voltage contact and at least one current interrupting contact in series; a cylindrical pressure vessel ; and bushings connected to the pressure vessel , the pressure vessel encapsulates the mechanical contact in its inside and is equipotential to a ground potential, the bushings withdraw conductors from both ends of the mechanical contact to an outside of the pressure vessel , and connect each of the conductors to a direct-current transmission system, characterized in that : the direct-current interrupting device comprises a semiconductor breaker ; and a commutation device , wherein the semiconductor breaker comprises: semiconductor modules ; module supporting plates ; and insulating poles , the semiconductor module comprises: a semiconductor stack made by layering two or more self-excited semiconductor elements in line and connecting them in series; an auxiliary circuit of the semiconductor stack ; and an insulation supporting unit , the insulation supporting unit electrically insulates the semiconductor stack and the auxiliary circuit against the module supporting plate , and mechanically connects the semiconductor stack and the auxiliary circuit to the module supporting plate , the insulating pole mechanically supports or fixes the module supporting plate , the semiconductor breaker is connected to the mechanical breaker in parallel, the commutation device is connected to at least the high-voltage contact of the high-voltage contact and the current interrupting contact of the mechanical breaker in parallel, and is connected to the semiconductor breaker in series, at a time of regular power transmission of the direct-current transmission system, transmission current only flows through the mechanical breaker , when accident current occurs in the direct-current transmission system, a path between the high-voltage contact and the current interrupting contact of the mechanical breaker is opened to make the self-excited semiconductor elements of the semiconductor breaker in a current-carrying state, and to make current flowing through the current interrupting contact temporarily zero by the commutation device , thereby transferring the accident current from the mechanical breaker to the semiconductor breaker , and the self-excited semiconductor elements of the semiconductor breaker are made in a blocking state after the accident current is transferred, thereby blocking the accident current of the direct-current transmission system.
Electrophotographic roller arrangement (1; 101; 201), comprising two rollers (2, 3; 102, 103; 202, 203), one of the rollers (3;103;203) having a resilient outer layer (10; 110; 210) extending substantially the length thereof, a nip (4; 104; 204) between the rollers (2, 3; 102, 103; 202, 203), and a substance feed arrangement for feeding substance to the nip (4; 104; 204), wherein the rollers (2, 3; 102, 103; 202, 203) are arranged to spread the substance along the nip (4; 104; 204), a respective coned portion (6; 106; 206) is provided at each end of one of the rollers (2;102;203) near an end of the nip (4; 104; 204), wherein the roller (2;102;203) has a substantially cylindrical shape along the nip (4; 104; 204) between said coned portions (6; 106; 206), and the other one of the rollers (3; 103; 203) has a substantially cylindrical shape along the nip (4; 104; 204), characterized in that the coned portions (6; 106; 206) are arranged to provide additional pressure on end portions (11; 111; 211) of the resilient outer layer (10; 110; 210) such that a relatively equal pressure is exerted onto the substance by the rollers (2, 3; 102, 103; 202, 203) along the length of the nip (4; 104; 204), compensating for the increased deformation that takes place at the end portions (11; 111; 211) of the resilient outer layer (10; 110; 210).
An asset inspection system, comprising: an asset controller configured to monitor one or more parameters associated with one or more assets and to control operation of the one or more assets ; one or more drones ; and a flight controller configured to communicate with the one or more drones and the asset controller and to coordinate operation of the asset with a flight plan followed by the one or more drones during an inspection, characterised in that the asset inspection system is configured to adjust the flight plan based on a yaw offset map generated at least in part using current environmental data. an asset controller configured to monitor one or more parameters associated with one or more assets and to control operation of the one or more assets ; one or more drones ; and a flight controller configured to communicate with the one or more drones and the asset controller and to coordinate operation of the asset with a flight plan followed by the one or more drones during an inspection, characterised in that the asset inspection system is configured to adjust the flight plan based on a yaw offset map generated at least in part using current environmental data.
A method of diagnosing an electric vehicle incorporating an electric component, the method comprising: detecting a physical load which is a physical amount indicative of the degree of a mechanical impact applied to the vehicle body of the electric vehicle ; storing a history of the magnitude of the detected physical load; determining (S402, S504) that the electric component is less likely to be damaged in a case in which a value obtained from the history of the magnitude of the physical load is within a predetermined normal range, and that the electric component is more likely to be damaged in the case in which the value falls outside the predetermined normal range; diagnosing (S405, S 507) whether or not there is an abnormality in the electric component in a first mode, in the case in which it is determined that the electric component is less likely to be damaged; and diagnosing (S406, S508) whether or not there is an abnormality in the electric component in a second mode different from the first mode, in the case in which it is determined that the electric component is more likely to be damaged, wherein the criterion used to determine whether or not there is an abnormality is set to be more strict in the second mode than in the first mode. detecting a physical load which is a physical amount indicative of the degree of a mechanical impact applied to the vehicle body of the electric vehicle ; storing a history of the magnitude of the detected physical load; determining (S402, S504) that the electric component is less likely to be damaged in a case in which a value obtained from the history of the magnitude of the physical load is within a predetermined normal range, and that the electric component is more likely to be damaged in the case in which the value falls outside the predetermined normal range; diagnosing (S405, S 507) whether or not there is an abnormality in the electric component in a first mode, in the case in which it is determined that the electric component is less likely to be damaged; and diagnosing (S406, S508) whether or not there is an abnormality in the electric component in a second mode different from the first mode, in the case in which it is determined that the electric component is more likely to be damaged, wherein the criterion used to determine whether or not there is an abnormality is set to be more strict in the second mode than in the first mode.
Fire protection method with a fire protection system comprising a fire protection installation with several fire protection units , each fire protection unit comprising at least one sensor and at least one fire protection device , each fire protection unit being controllable based on information from its own sensor , each fire protection unit being controllable individually and independently of the other fire protection units , and each fire protection unit being also controllable based on information from sensors of other fire protection units , with the following steps: - a fire protection unit detects a fire with its own sensor and implements a fire-fighting measure to extinguish the source of the fire; - a fire information is transmitted to other fire protection units remote from the fire; and - a fire protection unit remote from the source of the fire implements, on the basis of the fire information, a preventive measure to prevent the fire from spreading, characterized in that the preventive measure differs from the firefighting measure implemented to extinguish the source of the fire. with the following steps: - a fire protection unit detects a fire with its own sensor and implements a fire-fighting measure to extinguish the source of the fire; - a fire information is transmitted to other fire protection units remote from the fire; and - a fire protection unit remote from the source of the fire implements, on the basis of the fire information, a preventive measure to prevent the fire from spreading, - a fire protection unit detects a fire with its own sensor and implements a fire-fighting measure to extinguish the source of the fire; - a fire information is transmitted to other fire protection units remote from the fire; and - a fire protection unit remote from the source of the fire implements, on the basis of the fire information, a preventive measure to prevent the fire from spreading, characterized in that the preventive measure differs from the firefighting measure implemented to extinguish the source of the fire.
A method for preparing a nucleic acid derived from a skin cell of a subject, comprising isolating the nucleic acid from skin surface lipids collected from the subject, wherein the nucleic acid is mRNA, and the mRNA provides gene expression profiles of the sebaceous gland, hair follicle and dermis.
A wind turbine generator comprising: ice detecting means for detecting an amount of icing on a wind turbine blade , characterized in that in a case where an icing amount (Wi) detected by the ice detecting means exceeds a first predetermined value, an operation mode is switched to a no-load operation mode with no power being generated, and an icing amount is detected by the ice detecting means in a state where the wind turbine generator is operated in the no-load operation mode, wherein, in a case where an icing amount (Wi) exceeding a second predetermined value which is larger than the first predetermined value is detected by the ice detecting means in the state where the wind turbine generator is operated in the no-load operation mode, an operation is stopped. ice detecting means for detecting an amount of icing on a wind turbine blade , characterized in that in a case where an icing amount (Wi) detected by the ice detecting means exceeds a first predetermined value, an operation mode is switched to a no-load operation mode with no power being generated, and an icing amount is detected by the ice detecting means in a state where the wind turbine generator is operated in the no-load operation mode, wherein, in a case where an icing amount (Wi) exceeding a second predetermined value which is larger than the first predetermined value is detected by the ice detecting means in the state where the wind turbine generator is operated in the no-load operation mode, an operation is stopped.
Suspension and traction system (MC) for vehicles equipped with a frame and a propulsive element (R), which by rolling on the ground (T) is adapted to move the vehicle relative to the ground (T), comprising: - a rotary electric motor comprising two rotors which are rotatable with respect to a stator fixed on the frame, characterized in that the two rotors are independently controllable from one another, and in that the system (MC) further comprises - two epicycloidal mechanisms each comprising a central solar gear , meshing with satellite gears , meshing in turn with an outer ring gear ; wherein in each epicycloidal mechanism one among the solar gear and the satellite gears is coupled, respectively, to a rotor and the other among the solar gear and the satellite gears is connected/connectable to the propulsive element (R) to impart to it equiverse angular torque to propel the vehicle on the ground (T), and the two outer ring gears are independently movable to rotate about the respective solar gear and rigidly connected substantially to a same point (P) outside the epicycloidal mechanisms, wherein on said point (P) a thrust, determined by the coordinated angular displacement of the ring gears about the solar gears , can be imparted, so that said thrust can be discharged on the frame and/or an axle of the propulsive element (R).resulting in a position or level adjustment of said point (P), and therefore of the frame with respect to the propulsive element (R). - a rotary electric motor comprising two rotors which are rotatable with respect to a stator fixed on the frame, the two rotors are independently controllable from one another, and in that the system (MC) further comprises - two epicycloidal mechanisms each comprising a central solar gear , meshing with satellite gears , meshing in turn with an outer ring gear ; - two epicycloidal mechanisms each comprising a central solar gear , meshing with satellite gears , meshing in turn with an outer ring gear ; wherein in each epicycloidal mechanism one among the solar gear and the satellite gears is coupled, respectively, to a rotor and the other among the solar gear and the satellite gears is connected/connectable to the propulsive element (R) to impart to it equiverse angular torque to propel the vehicle on the ground (T), and the two outer ring gears are independently movable to rotate about the respective solar gear and rigidly connected substantially to a same point (P) outside the epicycloidal mechanisms, wherein on said point (P) a thrust, determined by the coordinated angular displacement of the ring gears about the solar gears , can be imparted, so that said thrust can be discharged on the frame and/or an axle of the propulsive element (R).resulting in a position or level adjustment of said point (P), and therefore of the frame with respect to the propulsive element (R).
An air conditioning device comprising: an indoor unit ; and an outdoor unit , wherein the indoor unit comprises a lidar configured to measure a line-of sight direction wind speed ; a wind measurement processing unit configured to calculate a wind direction value (Φ L , Θ L ) indicating a wind direction (Φ, O) using a value measured by the lidar ; and a blowing control unit configured to execute control of a blowing direction (Φ', O') using the wind direction value (Φ L , Θ L ) calculated by the wind measurement processing unit . an indoor unit ; and an outdoor unit , wherein the indoor unit comprises a lidar configured to measure a line-of sight direction wind speed ; a wind measurement processing unit configured to calculate a wind direction value (Φ L , Θ L ) indicating a wind direction (Φ, O) using a value measured by the lidar ; and a blowing control unit configured to execute control of a blowing direction (Φ', O') using the wind direction value (Φ L , Θ L ) calculated by the wind measurement processing unit .
A method of preparing human T-cell(s) for immunotherapy comprising: (a) Providing human T-cell (s) from a cell culture or from a blood sample; (b) Genetically modifying said T-cell(s) by inactivating at least: - a first gene encoding a immune checkpoint protein, and - a second gene encoding a component of the T-cell receptor (TCR); (c) Introducing into said T cell(s) a chimeric antigen receptor (CAR); and (d) expanding said T-cell(s), wherein said immune checkpoint gene is selected from the group consisting of: PD1, CTLA-4, LAG3, Tim3, BTLA, BY55, TIGIT, B7H5, LAIR1, SIGLEC10, and 2B4. (a) Providing human T-cell (s) from a cell culture or from a blood sample; (b) Genetically modifying said T-cell(s) by inactivating at least: - a first gene encoding a immune checkpoint protein, and - a second gene encoding a component of the T-cell receptor (TCR); - a first gene encoding a immune checkpoint protein, and - a second gene encoding a component of the T-cell receptor (TCR); (c) Introducing into said T cell(s) a chimeric antigen receptor (CAR); and (d) expanding said T-cell(s), wherein said immune checkpoint gene is selected from the group consisting of: PD1, CTLA-4, LAG3, Tim3, BTLA, BY55, TIGIT, B7H5, LAIR1, SIGLEC10, and 2B4.
A node for use in a wireless network , comprising: a communications unit for receiving a message using radio reception from a sender device in the wireless network , the message comprising a plurality of symbols and a first message integrity indicator located at a predetermined distance from the start of the message, wherein some of the symbols are located before the first message integrity indicator, while some of the symbols are located after the first message integrity indicator; a position identification unit for determining a position of the first message integrity indicator in the message; a message integrity indicator generator for performing a cryptographic operation on at least some of the symbols of the message located before the first message integrity indicator, but on none of the symbols located after the first message integrity indicator, so as to generate a second message integrity indicator before the first message integrity indicator is received; a comparator unit for comparing symbols of the second message integrity indicator with symbols of the first message integrity indicator while simultaneously receiving the symbols of the first message integrity indicator; the comparator unit indicating that the message is not authorized if the second message integrity indicator does not match the first message integrity indicator by sending an error signal to the position identification unit ; and the position identification unit disabling, from the sender device , further radio reception of the symbols of the message upon reception of the error signal from the comparator unit . a communications unit for receiving a message using radio reception from a sender device in the wireless network , the message comprising a plurality of symbols and a first message integrity indicator located at a predetermined distance from the start of the message, wherein some of the symbols are located before the first message integrity indicator, while some of the symbols are located after the first message integrity indicator; a position identification unit for determining a position of the first message integrity indicator in the message; a message integrity indicator generator for performing a cryptographic operation on at least some of the symbols of the message located before the first message integrity indicator, but on none of the symbols located after the first message integrity indicator, so as to generate a second message integrity indicator before the first message integrity indicator is received; a comparator unit for comparing symbols of the second message integrity indicator with symbols of the first message integrity indicator while simultaneously receiving the symbols of the first message integrity indicator; the comparator unit indicating that the message is not authorized if the second message integrity indicator does not match the first message integrity indicator by sending an error signal to the position identification unit ; and the position identification unit disabling, from the sender device , further radio reception of the symbols of the message upon reception of the error signal from the comparator unit .