mhurhangee/patent-ind-claim-en huggingface dataset:
An aqueous composition comprising a macrolide immunosuppressant drug at a concentration of less than 2% w/v and an amphiphilic carbohydrate compound having a molecular weight in the range 1-50kDa, for use in treatment of an eye disorder by topical application to the eye, wherein the amphiphilic carbohydrate compound is present at a concentration below 10% w/v of the composition, and is represented by the general formula: wherein a + b + c + d = 1.000 and a is between 0.00 and 0.84 b is between 0.01 and 0.40, c is between 0.00 and 0.84, and d is between 0.05 and 0.50; and wherein: X is a hydrophobic group; R 1 , R 2 and R 3 are independently selected from a substituted or unsubstituted alkyl group; R 4 , R 5 , R 6 and R 10 are independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; R 7 may be present or absent and, when present, is an unsubstituted or substituted alkyl group, an unsubstituted or substituted amine group or a substituted or unsubstituted amide group; R 8 and R 9 are independently selected from hydrogen and either a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; or a salt thereof. a is between 0.00 and 0.84 b is between 0.01 and 0.40, c is between 0.00 and 0.84, and d is between 0.05 and 0.50; and wherein: X is a hydrophobic group; R 1 , R 2 and R 3 are independently selected from a substituted or unsubstituted alkyl group; R 4 , R 5 , R 6 and R 10 are independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; R 7 may be present or absent and, when present, is an unsubstituted or substituted alkyl group, an unsubstituted or substituted amine group or a substituted or unsubstituted amide group; R 8 and R 9 are independently selected from hydrogen and either a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; or a salt thereof. X is a hydrophobic group; R 1 , R 2 and R 3 are independently selected from a substituted or unsubstituted alkyl group; R 4 , R 5 , R 6 and R 10 are independently selected from hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; R 7 may be present or absent and, when present, is an unsubstituted or substituted alkyl group, an unsubstituted or substituted amine group or a substituted or unsubstituted amide group; R 8 and R 9 are independently selected from hydrogen and either a substituted or unsubstituted alkyl group, a substituted or unsubstituted ether group, or a substituted or unsubstituted alkene group; or a salt thereof.
Grinding and extraction apparatus for roasted coffee beans comprising a grinding device and an associated extraction device ; the grinding device comprising one or more housings for receiving one or more bean containers with roasted coffee beans of the same or different types; the grinding device comprising a reader to obtain the information of the product parameters of the roasted coffee beans of the one or more bean containers ; the grinding device further comprising a control unit configured to adapt the grinding size and the quantity of roasted coffee beans for obtaining a certain coffee blend from each bean container to be grinded according to these product parameters and/or according to a recipes database comprising the beverage information associated to the beverage to be prepared; the extraction device being configured for receiving a product holder and comprising reading means to identify the beverage information in a product holder identification means , the extraction device further comprising a control unit to extract the beverage according to the beverage information retrieved and/or from the beverage information retrieved from a beverage database in this control unit; the grinding and extraction apparatus for roasted coffee beans is characterized in that the grinding device further comprises an encoder to encode the beverage information on said programmable identification means on the product holder in the grinding device , to where the ground coffee is sent. the grinding device comprising one or more housings for receiving one or more bean containers with roasted coffee beans of the same or different types; the grinding device comprising a reader to obtain the information of the product parameters of the roasted coffee beans of the one or more bean containers ; the grinding device further comprising a control unit configured to adapt the grinding size and the quantity of roasted coffee beans for obtaining a certain coffee blend from each bean container to be grinded according to these product parameters and/or according to a recipes database comprising the beverage information associated to the beverage to be prepared; the extraction device being configured for receiving a product holder and comprising reading means to identify the beverage information in a product holder identification means , the extraction device further comprising a control unit to extract the beverage according to the beverage information retrieved and/or from the beverage information retrieved from a beverage database in this control unit; the grinding and extraction apparatus for roasted coffee beans is characterized in that the grinding device further comprises an encoder to encode the beverage information on said programmable identification means on the product holder in the grinding device , to where the ground coffee is sent.
Nivolumab for use in the treatment of a non-small cell lung cancer with ALK translocation, wherein nivolumab is administered in combination with ceritinib.
A negative electrode for a lithium secondary battery, comprising: a lithium metal layer; and a protective layer formed on at least one side of the lithium metal layer, wherein the protective layer comprises a material that forms a Schottky junction with lithium metal; wherein the protective layer has an activation energy for migration of lithium ions of 0.95 eV or less, wherein the activation energy is measured by the nudged elastic band method; and wherein the lithium metal layer is formed by forming a lithium metal thin film on a current collector. a lithium metal layer; and a protective layer formed on at least one side of the lithium metal layer, wherein the protective layer comprises a material that forms a Schottky junction with lithium metal; wherein the protective layer has an activation energy for migration of lithium ions of 0.95 eV or less, wherein the activation energy is measured by the nudged elastic band method; and wherein the lithium metal layer is formed by forming a lithium metal thin film on a current collector.
A vacuum system comprising a vacuum device, in particular a vacuum pump; a functional element, in particular a drive device, for the vacuum device; and an adapter by means of which the vacuum device is or can be connected to the functional element in an IT regard, wherein the adapter comprises: a base element ; a first and a second primary plug connector , each for connection to one of the vacuum device and the functional element, wherein the primary plug connectors are connected to one another; and a module which is separate from the base element , which has the first primary plug connector and which is fastened to the base element , wherein the base element and the module each have an intermediate connector , said intermediate connectors together forming an intermediate connection via which the first primary plug connector is connected to the second primary plug connector . a vacuum device, in particular a vacuum pump; a functional element, in particular a drive device, for the vacuum device; and an adapter by means of which the vacuum device is or can be connected to the functional element in an IT regard, wherein the adapter comprises: a base element ; a first and a second primary plug connector , each for connection to one of the vacuum device and the functional element, wherein the primary plug connectors are connected to one another; and a module which is separate from the base element , which has the first primary plug connector and which is fastened to the base element , wherein the base element and the module each have an intermediate connector , said intermediate connectors together forming an intermediate connection via which the first primary plug connector is connected to the second primary plug connector . a base element ; a first and a second primary plug connector , each for connection to one of the vacuum device and the functional element, wherein the primary plug connectors are connected to one another; and a module which is separate from the base element , which has the first primary plug connector and which is fastened to the base element , wherein the base element and the module each have an intermediate connector , said intermediate connectors together forming an intermediate connection via which the first primary plug connector is connected to the second primary plug connector .
A digital system comprising a first clock domain comprising a first clock, a second clock domain comprising a second clock (ck), wherein the first and second clocks are unsynchronized, said digital system further comprising an arrangement for transferring a data signal from the first clock domain to the second clock domain , the arrangement comprising: a signal input comprising a flip-flop for receiving and storing an input signal (data_a) from the first clock domain, wherein the flip flop is clocked by the second clock (ck); and means for transferring the input signal to the second clock domain following a transition in the clock signal of the second clock domain; characterised in that : the input signal is fed to a "set" (S) input of the flip-flop and a "data" (D) input of the flip-flop is connected to ground. a signal input comprising a flip-flop for receiving and storing an input signal (data_a) from the first clock domain, wherein the flip flop is clocked by the second clock (ck); and means for transferring the input signal to the second clock domain following a transition in the clock signal of the second clock domain; characterised in that : the input signal is fed to a "set" (S) input of the flip-flop and a "data" (D) input of the flip-flop is connected to ground.
An automatic coffee grinding capsule making machine, wherein, the said maker consists of a base , an automatic rotating operation platform , a coffee cup unloading device , a coffee bean grinding device , a coffee powder temporary storage device , a powder tamping and removal device , a coffee cap unloading device and a capping device ; the said automatic rotating operation platform is provided at the said base ; the said automatic rotating operation platform can rotate based on a coffee capsule making status; there are several first holes at the said automatic rotating operation platform , and there are several first detecting devices below the said automatic rotating operation platform ; the said first holes are used for bearing a coffee cup ; the said first detecting devices are configured for detecting the working position of the coffee cup at the automatic rotating operation platform ; the said coffee bean grinding device , the said coffee powder temporary storage device , the said powder tamping and removal device , the said coffee cup unloading device , the said coffee cap unloading device and the said capping device are fixed to the said base ; the said coffee bean milling device consists of a first motor , a coffee bean storage bunker , a rotating shaft , a grinding burr assembly, a coffee powder collector and a powder scraper ; the said first motor is transversely fixed and connected to the said rotating shaft , the said coffee bean storage bunker , the said grinder burr assembly and the said powder scraper are fixed to the said rotating shaft in turn and toward the direction away from the first motor , the said powder scraper is fixed to the end of the said rotating shaft ; the said powder scraper is inside the said coffee powder collector .
An environmental equipment control apparatus for controlling a plurality of types of environmental equipment , comprising: a grasping unit configured to grasp current physical and mental state information about a current physical and mental state of a user, environmental situation information, and target relationship information representing a relationship between a target physical and mental state and the current physical and mental state; learning control plan output means configured to output a control change plan for each of combinations of the plurality of types of environmental equipment in accordance with the current physical and mental state information, the environmental situation information, and the target relationship information; and a selection control unit that selects, based on a predetermined condition, one control change plan from among a plurality of the control change plans output by the learning control plan output means after excluding a control change plan satisfying a predetermined exclusion condition, and executes the one control change plan, wherein the learning control plan output means learns to update a method for specifying the control change plan to be output, by using a physical and mental state of the user changed by executing the control change plan selected by the selection control unit. a grasping unit configured to grasp current physical and mental state information about a current physical and mental state of a user, environmental situation information, and target relationship information representing a relationship between a target physical and mental state and the current physical and mental state; learning control plan output means configured to output a control change plan for each of combinations of the plurality of types of environmental equipment in accordance with the current physical and mental state information, the environmental situation information, and the target relationship information; and a selection control unit that selects, based on a predetermined condition, one control change plan from among a plurality of the control change plans output by the learning control plan output means after excluding a control change plan satisfying a predetermined exclusion condition, and executes the one control change plan, wherein the learning control plan output means learns to update a method for specifying the control change plan to be output, by using a physical and mental state of the user changed by executing the control change plan selected by the selection control unit.
A floating wind power platform for offshore power production, comprising: a floating unit , wherein the floating unit comprises a first, a second and a third interconnected semisubmersible column each being arranged in a respective corner of the floating unit , the floating wind power platform further comprising a first and second wind turbine , arranged to the first and second semisubmersible columns , respectively, via a first and second tower respectively, wherein a tension leg device is arranged solely to the third semisubmersible column , wherein the tension leg device is adapted to be anchored to the seabed by an anchoring device , and wherein the third semisubmersible column provides a buoyancy force adapted to create a tension force in the tension leg device , wherein the floating wind power platform is further adapted to weather vane in relation to the wind direction, wherein a turret is arranged to the third semisubmersible column . a floating unit , wherein the floating unit comprises a first, a second and a third interconnected semisubmersible column each being arranged in a respective corner of the floating unit , the floating wind power platform further comprising a first and second wind turbine , arranged to the first and second semisubmersible columns , respectively, via a first and second tower respectively, wherein a tension leg device is arranged solely to the third semisubmersible column , wherein the tension leg device is adapted to be anchored to the seabed by an anchoring device , and wherein the third semisubmersible column provides a buoyancy force adapted to create a tension force in the tension leg device , wherein the floating wind power platform is further adapted to weather vane in relation to the wind direction, wherein a turret is arranged to the third semisubmersible column .
A radiological threat monitoring system , comprising: at least one cable comprising a scintillating substance having an enclosed, elongated interior volume for carrying light emitted within the at least one cable by the scintillating substance when struck by ionizing radiation from a radiological material emitting ionizing radiation when the radiological material is within a predefined distance from the at least one cable; and characterised in that the system further comprises: a plurality of light sensitive detectors arranged along a length of the at least one cable for measuring a signal corresponding to the emitted light, wherein the detectors record the measured signal.
Guidance system for dynamically guiding a surgical needle catheter onto an organ of a patient, which is to be surgically operated, comprising: an electromagnetic, EM, catheter, for inserting into the patient and for defining a desired location to be reached by the surgical needle catheter; an EM tracker for tracking of a location and orientation of the surgical needle catheter and of a location of a tip of the EM catheter; and an electronic data processor arranged for: displaying a 2D concentric-ring target, wherein the target is on a plane intersecting the tip of the EM catheter, and the plane is perpendicular to the orientation of the surgical needle catheter; continuously displaying a projection, orthogonal to the plane, of a line coincident with the surgical needle catheter onto said target; and continuously displaying a plurality of concentric rings of the 2D concentric-ring target centred around the tip of the EM catheter. an electromagnetic, EM, catheter, for inserting into the patient and for defining a desired location to be reached by the surgical needle catheter; an EM tracker for tracking of a location and orientation of the surgical needle catheter and of a location of a tip of the EM catheter; and an electronic data processor arranged for: displaying a 2D concentric-ring target, wherein the target is on a plane intersecting the tip of the EM catheter, and the plane is perpendicular to the orientation of the surgical needle catheter; continuously displaying a projection, orthogonal to the plane, of a line coincident with the surgical needle catheter onto said target; and continuously displaying a plurality of concentric rings of the 2D concentric-ring target centred around the tip of the EM catheter. displaying a 2D concentric-ring target, wherein the target is on a plane intersecting the tip of the EM catheter, and the plane is perpendicular to the orientation of the surgical needle catheter; continuously displaying a projection, orthogonal to the plane, of a line coincident with the surgical needle catheter onto said target; and continuously displaying a plurality of concentric rings of the 2D concentric-ring target centred around the tip of the EM catheter.
A method for producing a first intermediate product, comprising the steps of a. providing a feedstock that comprises a first polyester; b. contacting the first polyester with a further amount of a first organic compound in a volume section V 2 , wherein i. at least one impurity is present in the volume section V 2 , and ii. the volume section V 2 has a first zone and a further zone ; c. reducing a weight average molar mass of the first polyester in the volume section V 2 , wherein after the reduction step has been completed, the first polyester has an intrinsic viscosity in the range of 0.10 dL/g to 0.45 dL/g; d. transporting the first polyester to a volume section V 3 ; e. contacting the first polyester with a further organic compound in the volume section V 3 to obtain a further initial mixture; f. reducing the weight average molar mass of the first polyester in the volume section V 3 to obtain a first intermediate mixture, wherein the first intermediate mixture comprises i. a first intermediate product that has an intrinsic viscosity in the range of 0.010 dL/g to 0.090 dL/g, ii. the further organic compound; wherein a relative ratio of a particle count per area of the at least one impurity in the first zone to a particle count per area of the at least one impurity in the further zone is equal to or greater than 10 and equal to or less than 1000, with the intrinsic viscosity and the relative ratio of the particle count per area of the at least one impurity determined according to the methods described herein. a. providing a feedstock that comprises a first polyester; b. contacting the first polyester with a further amount of a first organic compound in a volume section V 2 , wherein i. at least one impurity is present in the volume section V 2 , and ii. the volume section V 2 has a first zone and a further zone ; i. at least one impurity is present in the volume section V 2 , and ii. the volume section V 2 has a first zone and a further zone ; c. reducing a weight average molar mass of the first polyester in the volume section V 2 , wherein after the reduction step has been completed, the first polyester has an intrinsic viscosity in the range of 0.10 dL/g to 0.45 dL/g; d. transporting the first polyester to a volume section V 3 ; e. contacting the first polyester with a further organic compound in the volume section V 3 to obtain a further initial mixture; f. reducing the weight average molar mass of the first polyester in the volume section V 3 to obtain a first intermediate mixture, wherein the first intermediate mixture comprises i. a first intermediate product that has an intrinsic viscosity in the range of 0.010 dL/g to 0.090 dL/g, ii. the further organic compound; i. a first intermediate product that has an intrinsic viscosity in the range of 0.010 dL/g to 0.090 dL/g, ii. the further organic compound;