mhurhangee/patent-ind-claim-en huggingface dataset:
A driver circuit for driving a light source , the circuit comprising a plurality of current control units (102(i)-102(iv)) , each of the plurality of current control units (102(i)-102(iv)) comprising: a first node for coupling to a first terminal of the light source ; a second node for coupling to a second terminal of the light source ; a current source ; a first current path , coupled between the first node and the current source ; a second current path coupled between the second node and the current source , wherein the current control unit is operable: in a first mode of operation, to drive current from a first potential to a second potential to turn on the light source , wherein the said current is driven through the light source and through the first current path and the current source ; and in a second mode of operation, to drive current from the first potential to the second potential and bypass the light source to turn off the light source, wherein the said current is driven through the second current path and the current source , wherein the plurality of current control units are coupled in parallel to each other at the respective first and second nodes. a first node for coupling to a first terminal of the light source ; a second node for coupling to a second terminal of the light source ; a current source ; a first current path , coupled between the first node and the current source ; a second current path coupled between the second node and the current source , wherein the current control unit is operable: in a first mode of operation, to drive current from a first potential to a second potential to turn on the light source , wherein the said current is driven through the light source and through the first current path and the current source ; and in a second mode of operation, to drive current from the first potential to the second potential and bypass the light source to turn off the light source, wherein the said current is driven through the second current path and the current source , in a first mode of operation, to drive current from a first potential to a second potential to turn on the light source , wherein the said current is driven through the light source and through the first current path and the current source ; and in a second mode of operation, to drive current from the first potential to the second potential and bypass the light source to turn off the light source, wherein the said current is driven through the second current path and the current source ,
An oligonucleotide comprising the sequence of formula III: 5'-dA*+T*dG*+G*dC*+T*dG*+T*dA*+G*dA*dC*dT*dG*+T*+T-3' wherein dA is 2'deoxyadenosine, dG is 2'deoxyguanosine, dC is 2'deoxycytidine and T is thymidine, wherein +T is an LNA-T building block and +G is an LNA-G building block and wherein * is a phosphorothioate linkage, for use in the prevention or treatment of a cardiac disorder in a human subject, wherein the cardiac disorder is selected from (i) acute or subacute heart failure, (ii) chronic and/or worsening chronic heart failure, (iii) stable heart failure, (iv) a less advanced state of heart failure or from an advanced state of heart failure, (v) heart failure of NYHA stage I and/or II, NYHA stage I, II and/or III or of NYHA stage III and/or IV, and (vi) right-sided heart failure. wherein dA is 2'deoxyadenosine, dG is 2'deoxyguanosine, dC is 2'deoxycytidine and T is thymidine, wherein +T is an LNA-T building block and +G is an LNA-G building block and wherein * is a phosphorothioate linkage, for use in the prevention or treatment of a cardiac disorder in a human subject, wherein the cardiac disorder is selected from (i) acute or subacute heart failure, (ii) chronic and/or worsening chronic heart failure, (iii) stable heart failure, (iv) a less advanced state of heart failure or from an advanced state of heart failure, (v) heart failure of NYHA stage I and/or II, NYHA stage I, II and/or III or of NYHA stage III and/or IV, and (vi) right-sided heart failure.
Hygienization device for hygienization and disinfection of cutting tools, especially knives, with: - a housing device that encloses a hygienization interior , - an insertion opening for inserting the cutting tool into the hygienization interior and - an application device for applying a hygienization medium onto the contact surfaces of the cutting tool located in the sanitization interior, Characterized in that , - the insertion opening is designed in such a manner that the cutting tool is capable of being introduced into the hygienization interior together with a hand holding same at a handle section . - a housing device that encloses a hygienization interior , - an insertion opening for inserting the cutting tool into the hygienization interior and - an application device for applying a hygienization medium onto the contact surfaces of the cutting tool located in the sanitization interior, - the insertion opening is designed in such a manner that the cutting tool is capable of being introduced into the hygienization interior together with a hand holding same at a handle section .
An organic electronic device comprising an anode , a cathode , at least one photoactive layer , and at least one semiconductor layer ; wherein the at least one semiconductor layer is arranged between the anode and at least one photoactive layer, wherein the at least one semiconductor layer comprises a compound comprising a metal M and at least one ligand L represented by formula wherein - R 1 is independently selected from a substituted or unsubstituted C 1 to C 20 alkyl, a substituted or unsubstituted C 3 to C 20 carbocyclyl, a substituted or unsubstituted C 2 to C 20 heterocyclyl, a substituted or unsubstituted C 6 to C 20 aryl, or a substituted or unsubstituted C 2 to C 20 heteroaryl; - R 2 is independently selected from a substituted or unsubstituted C 1 to C 20 alkyl, a substituted or unsubstituted C 3 to C 20 carbocyclyl, a substituted or unsubstituted C 2 to C 20 heterocyclyl, a substituted or unsubstituted C 6 to C 20 aryl, or a substituted or unsubstituted C 2 to C 20 heteroaryl; - R 1 and R 2 can be connected via a direct bond; and - R 1 and/or R 2 taken together with the neighboring sulfur, nitrogen or carbon atom can form a ring, and the ring may be a substituted or unsubstituted ring or a substituted or unsubstituted polycyclic ring or substituted or unsubstituted condensed rings. - R 1 is independently selected from a substituted or unsubstituted C 1 to C 20 alkyl, a substituted or unsubstituted C 3 to C 20 carbocyclyl, a substituted or unsubstituted C 2 to C 20 heterocyclyl, a substituted or unsubstituted C 6 to C 20 aryl, or a substituted or unsubstituted C 2 to C 20 heteroaryl; - R 2 is independently selected from a substituted or unsubstituted C 1 to C 20 alkyl, a substituted or unsubstituted C 3 to C 20 carbocyclyl, a substituted or unsubstituted C 2 to C 20 heterocyclyl, a substituted or unsubstituted C 6 to C 20 aryl, or a substituted or unsubstituted C 2 to C 20 heteroaryl; - R 1 and R 2 can be connected via a direct bond; and - R 1 and/or R 2 taken together with the neighboring sulfur, nitrogen or carbon atom can form a ring, and the ring may be a substituted or unsubstituted ring or a substituted or unsubstituted polycyclic ring or substituted or unsubstituted condensed rings.
A rotating display for creating a three-dimensional image, the rotating display comprising: a display panel configured to rotate about an axis , the display panel comprising a plurality of groups of light emitting elements , each group of light emitting elements comprising a plurality of subsets of light emitting elements, each light emitting element being individually controllable and configured to display a plurality of pixels of the three-dimensional image; a processor configured to receive pixel data for the display panel and divide the pixel data into a plurality of pixel data lines, each pixel data line comprising pixel data for only one of the groups of light emitting elements; and one or more buffers , wherein each buffer is configured to receive only one data line from the processor ; wherein the display panel is configured to rotate about the axis at a rate commensurate with the refresh rate of the display panel, the rotating display further comprising: for each group of light emitting elements: a demultiplexer configured to receive a respective pixel data line from a buffer and provide pixel data to each light emitting element of the group according to a refresh rate of the display panel; and wherein each output of the demultiplexer is configured to provide data to only one of the subsets of light emitting elements. a display panel configured to rotate about an axis , the display panel comprising a plurality of groups of light emitting elements , each group of light emitting elements comprising a plurality of subsets of light emitting elements, each light emitting element being individually controllable and configured to display a plurality of pixels of the three-dimensional image; a processor configured to receive pixel data for the display panel and divide the pixel data into a plurality of pixel data lines, each pixel data line comprising pixel data for only one of the groups of light emitting elements; and one or more buffers , wherein each buffer is configured to receive only one data line from the processor ; wherein the display panel is configured to rotate about the axis at a rate commensurate with the refresh rate of the display panel, the rotating display further comprising: for each group of light emitting elements: a demultiplexer configured to receive a respective pixel data line from a buffer and provide pixel data to each light emitting element of the group according to a refresh rate of the display panel; and wherein each output of the demultiplexer is configured to provide data to only one of the subsets of light emitting elements. a demultiplexer configured to receive a respective pixel data line from a buffer and provide pixel data to each light emitting element of the group according to a refresh rate of the display panel; and wherein each output of the demultiplexer is configured to provide data to only one of the subsets of light emitting elements.
An optical shape sensing system comprising - a first optical fiber (OSF1) comprising optical shape sensing elements, - a second optical fiber (OSF2) comprising optical shape sensing elements, - a processor (P) arranged to register a first coordinate system indicative of a position of the first optical fiber (OSF1) in space, and to register a position (R2) of the second optical fiber (OSF2) in relation to the first coordinate system, and - an optical console system (C, C1, C2) arranged for interrogating the optical shape sensing elements in both of the first and second optical fibers (OSF1, OSF2), and to accordingly determine a measure of a three-dimensional shape (I) of at least parts of both of the first and second optical fibers (OSF1, OSF2), based on the registered position (R2) of the second optical fiber (OSF2) in relation to the first coordinate system, characterized in that the first optical fiber (OSF1) and the second optical fiber (OSF2) are mechanically concatenated so that the second optical fiber (OSF2) serves to extend an effective length of the first optical fiber (OSF1) or to improve accuracy of a three-dimensional shape reconstruction of the first optical fiber (OSF1), and the processor (P) is arranged to register a position in space (R2) and an orientation of a proximal part of the second optical fiber (OSF2) in relation to the first coordinate system. - a first optical fiber (OSF1) comprising optical shape sensing elements, - a second optical fiber (OSF2) comprising optical shape sensing elements, - a processor (P) arranged to register a first coordinate system indicative of a position of the first optical fiber (OSF1) in space, and to register a position (R2) of the second optical fiber (OSF2) in relation to the first coordinate system, and - an optical console system (C, C1, C2) arranged for interrogating the optical shape sensing elements in both of the first and second optical fibers (OSF1, OSF2), and to accordingly determine a measure of a three-dimensional shape (I) of at least parts of both of the first and second optical fibers (OSF1, OSF2), based on the registered position (R2) of the second optical fiber (OSF2) in relation to the first coordinate system,
A cooling system valve for an internal combustion engine cooling system , said internal combustion engine cooling system comprising a radiator and a coolant passage adapted to cool at least a portion of an internal combustion engine , said cooling system valve being adapted to be located between said radiator and said coolant passage , as seen in an intended direction of flow from said radiator to said coolant passage , said cooling system valve being adapted to automatically assume each one of at least the following conditions: - an open condition, allowing coolant transport from said radiator towards said coolant passage via said cooling system valve , and - a closed condition, preventing coolant transport in a direction from said coolant passage towards said radiator via said cooling system valve , wherein said cooling system valve is adapted to automatically assume each one of said conditions in dependence of a pressure upstream said cooling system valve , as seen in an intended direction of flow from said radiator to said coolant passage , wherein said cooling system valve comprises a valve member and a valve housing , said valve member being moveable relative to said valve housing to thereby obtain said open and closed conditions, the position of said valve member relative to said valve housing being controlled by said pressure upstream said cooling system valve , wherein said valve member is adapted to pivot relative said valve housing , characterized in that said cooling system valve comprises a pressure actuated valve member actuator , adapted to move said valve member relative to said valve housing under action of the fluid pressure upstream said cooling system valve, said cooling system valve further comprising a pilot pressure conduit in fluid communication with said valve member actuator . - an open condition, allowing coolant transport from said radiator towards said coolant passage via said cooling system valve , and - a closed condition, preventing coolant transport in a direction from said coolant passage towards said radiator via said cooling system valve ,
A combination comprising: (a) a Mcl-1 inhibitor which is (2 R )-2-{[(5 S a )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(5-fluorofuran-2-yl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[1-(2,2,2-trifluoroethyl)-1 H -pyrazol-5-yl]methoxy}phenyl)propanoic acid or (2 R )-2-{[(5 S a )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid, and (b) a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines selected from idarubicin, daunorubicin and mitoxanthrone, cytarabine and hypomethylating agents selected from decitabine, azacitidine and guadecitabine, for simultaneous, sequential or separate use. (a) a Mcl-1 inhibitor which is (2 R )-2-{[(5 S a )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(5-fluorofuran-2-yl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[1-(2,2,2-trifluoroethyl)-1 H -pyrazol-5-yl]methoxy}phenyl)propanoic acid or (2 R )-2-{[(5 S a )-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3- d ]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid, and (b) a second anticancer agent, wherein the second anticancer agent is selected from anthracyclines selected from idarubicin, daunorubicin and mitoxanthrone, cytarabine and hypomethylating agents selected from decitabine, azacitidine and guadecitabine, for simultaneous, sequential or separate use.
A method for minimizing common mode interference in a physiological measurement system having input channels and analog circuitry electrically coupled to electrodes for measuring an electrophysiological signal, the method comprising: receiving analog test signals at the input channels; generating response signals at the analog circuitry in response to receiving the analog test signals; converting each response signal into digital data samples ; storing, in a memory of the physiological measurement system, the digital data samples in association with each of the input channels; analyzing the digital data samples for each of the input channels to determine a reference input channel; determining a set of digital filter coefficients for each input channel other than the reference input channel; and applying a filter to each input channel during operation of said physiological measurement system, wherein each filter operates according to a digital filter coefficient from the set of digital filter coefficients to minimize time-domain differences between the reference input channel and each input channel other than the reference input channel, characterised in that analyzing the digital data samples for each of the input channels to determine the reference input channel comprises one of: identifying a response signal corresponding to a last zero crossing; and identifying a response signal corresponding to a slowest slew rate. receiving analog test signals at the input channels; generating response signals at the analog circuitry in response to receiving the analog test signals; converting each response signal into digital data samples ; storing, in a memory of the physiological measurement system, the digital data samples in association with each of the input channels; analyzing the digital data samples for each of the input channels to determine a reference input channel; determining a set of digital filter coefficients for each input channel other than the reference input channel; and applying a filter to each input channel during operation of said physiological measurement system, wherein each filter operates according to a digital filter coefficient from the set of digital filter coefficients to minimize time-domain differences between the reference input channel and each input channel other than the reference input channel, identifying a response signal corresponding to a last zero crossing; and identifying a response signal corresponding to a slowest slew rate.
A method, comprising: receiving at a wireless energy receiver wireless energy from a wireless energy transmitter device ; determining a received power level value of the wireless energy; monitoring a temperature of the wireless energy receiver ; characterized in that the method further comprises: manipulating the received power level value based on the monitored temperature by increasing the determined received power level value by an offset value to obtain a manipulated power level value , wherein a first offset value is used when the temperature is under a temperature threshold and a second offset value is used when the temperature is above the temperature threshold; and sending the manipulated power level value to the wireless energy transmitter device . receiving at a wireless energy receiver wireless energy from a wireless energy transmitter device ; determining a received power level value of the wireless energy; monitoring a temperature of the wireless energy receiver ; characterized in that the method further comprises: manipulating the received power level value based on the monitored temperature by increasing the determined received power level value by an offset value to obtain a manipulated power level value , wherein a first offset value is used when the temperature is under a temperature threshold and a second offset value is used when the temperature is above the temperature threshold; and sending the manipulated power level value to the wireless energy transmitter device . manipulating the received power level value based on the monitored temperature by increasing the determined received power level value by an offset value to obtain a manipulated power level value , wherein a first offset value is used when the temperature is under a temperature threshold and a second offset value is used when the temperature is above the temperature threshold; and sending the manipulated power level value to the wireless energy transmitter device .
A process for preparing a compound represented by formula , 2-chloro-4-[ -3-cyclopentyl-7-(4-hydroxypiperidin-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl]benzonitrile, which is characterized by comprising the steps of: Chirally resolving ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate to produce -ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate; Hydrolyzing -ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate to produce -2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid; Subjecting -2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid and 4-hydroxypiperidine to a condensation reaction to produce the compound represented by formula . Chirally resolving ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate to produce -ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate; Hydrolyzing -ethyl 2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylate to produce -2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid; Subjecting -2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinoline-7-carboxylic acid and 4-hydroxypiperidine to a condensation reaction to produce the compound represented by formula .