mhurhangee/patent-ind-claim-en huggingface dataset:
A gas turbine engine comprises: a fan drive turbine driving a gear reduction , said gear reduction , in turn, driving a fan rotor , said fan rotor delivering air into a bypass duct as bypass air and into a compressor section as core flow; a forward bearing positioned between said gear reduction and said fan rotor and supporting said gear reduction , and a second bearing positioned aft of said gear reduction and supporting said gear reduction , said forward bearing being a thrust bearing ; a fan drive turbine drive shaft driving said gear reduction ; and a catcher provided to resist movement of said gear reduction and said fan rotor in an outer direction in the event of a failure of said forward bearing , wherein said gear reduction is an epicyclic gear reduction , wherein said epicyclic gear reduction includes a sun gear , intermediate gears driven by said sun gear , and a ring gear driven by said intermediate gears , with a static carrier , and said ring gear driving a fan drive shaft to drive said fan rotor , characterized in that : said catcher is bolted to a frame structure associated with said static carrier . a fan drive turbine driving a gear reduction , said gear reduction , in turn, driving a fan rotor , said fan rotor delivering air into a bypass duct as bypass air and into a compressor section as core flow; a forward bearing positioned between said gear reduction and said fan rotor and supporting said gear reduction , and a second bearing positioned aft of said gear reduction and supporting said gear reduction , said forward bearing being a thrust bearing ; a fan drive turbine drive shaft driving said gear reduction ; and a catcher provided to resist movement of said gear reduction and said fan rotor in an outer direction in the event of a failure of said forward bearing , wherein said gear reduction is an epicyclic gear reduction , wherein said epicyclic gear reduction includes a sun gear , intermediate gears driven by said sun gear , and a ring gear driven by said intermediate gears , with a static carrier , and said ring gear driving a fan drive shaft to drive said fan rotor ,
Tyre comprising a rubber composition based on: - an elastomeric matrix comprising predominantly a random copolymer comprising ethylene units and conjugated diene units, the mole fraction of the ethylene units in the copolymer being within a range extending from 50% to 95%, - at least one peroxide, and - at least one acrylate derivative of formula (I) in which: ∘ R 1 , R 2 and R 3 independently of one another represent a hydrogen atom or a C 1 -C 8 hydrocarbon group selected from linear, branched or cyclic alkyl groups, aralkyl groups, alkylaryl groups and aryl groups, and which are optionally interrupted by one or more heteroatoms, its being possible for R 2 et R 3 together to form a nonaromatic ring, ∘ R 4 represents a C 1 -C 30 hydrocarbon group selected from linear, branched or cyclic alkyl groups, which are optionally interrupted and/or substituted by one or more heteroatoms. - an elastomeric matrix comprising predominantly a random copolymer comprising ethylene units and conjugated diene units, the mole fraction of the ethylene units in the copolymer being within a range extending from 50% to 95%, - at least one peroxide, and - at least one acrylate derivative of formula (I) in which: ∘ R 1 , R 2 and R 3 independently of one another represent a hydrogen atom or a C 1 -C 8 hydrocarbon group selected from linear, branched or cyclic alkyl groups, aralkyl groups, alkylaryl groups and aryl groups, and which are optionally interrupted by one or more heteroatoms, its being possible for R 2 et R 3 together to form a nonaromatic ring, ∘ R 4 represents a C 1 -C 30 hydrocarbon group selected from linear, branched or cyclic alkyl groups, which are optionally interrupted and/or substituted by one or more heteroatoms. ∘ R 1 , R 2 and R 3 independently of one another represent a hydrogen atom or a C 1 -C 8 hydrocarbon group selected from linear, branched or cyclic alkyl groups, aralkyl groups, alkylaryl groups and aryl groups, and which are optionally interrupted by one or more heteroatoms, its being possible for R 2 et R 3 together to form a nonaromatic ring, ∘ R 4 represents a C 1 -C 30 hydrocarbon group selected from linear, branched or cyclic alkyl groups, which are optionally interrupted and/or substituted by one or more heteroatoms.
A bevacizumab antibody or biosimilar thereof and albumin-bound chemotherapeutic/bevacizumab antibody or biosimilar thereof nanoparticle complexes for use in a method of treating cancer which expresses vascular endothelial growth factor (VEGF) in a patient, wherein said patient is treated with a sub-therapeutic amount of the bevacizumab antibody or biosimilar thereof and the albumin-bound chemotherapeutic/ bevacizumab antibody or biosimilar thereof nanoparticle complexes containing a therapeutically effective amount of the chemotherapeutic such that the administration of said sub-therapeutic amount of the bevacizumab antibody or biosimilar thereof enhances the efficacy of said nanoparticle complexes, wherein the sub-therapeutic amount of bevacizumab antibody or biosimilar thereof is administered from between about 30 minutes to about 48 hours prior to administration of the albumin-bound chemotherapeutic/ bevacizumab antibody or biosimilar thereof nanoparticle complexes, wherein a therapeutic dosage of the bevacizumab antibody or biosimilar thereof is 5 mg/kg to 15 mg/kg; and wherein the sub-therapeutic amount of bevacizumab antibody or biosimilar thereof is selected from an amount consisting of 1%, 5%, 10%, 15%, 20%, 25% or 30% of the therapeutic dosage of bevacizumab antibody or biosimilar thereof. wherein said patient is treated with a sub-therapeutic amount of the bevacizumab antibody or biosimilar thereof and the albumin-bound chemotherapeutic/ bevacizumab antibody or biosimilar thereof nanoparticle complexes containing a therapeutically effective amount of the chemotherapeutic such that the administration of said sub-therapeutic amount of the bevacizumab antibody or biosimilar thereof enhances the efficacy of said nanoparticle complexes, wherein the sub-therapeutic amount of bevacizumab antibody or biosimilar thereof is administered from between about 30 minutes to about 48 hours prior to administration of the albumin-bound chemotherapeutic/ bevacizumab antibody or biosimilar thereof nanoparticle complexes, wherein a therapeutic dosage of the bevacizumab antibody or biosimilar thereof is 5 mg/kg to 15 mg/kg; and wherein the sub-therapeutic amount of bevacizumab antibody or biosimilar thereof is selected from an amount consisting of 1%, 5%, 10%, 15%, 20%, 25% or 30% of the therapeutic dosage of bevacizumab antibody or biosimilar thereof.
A method for maintaining coherence of waves emitted from a plurality of ultrasound transducer arrays connected via a connecting frame , each transducer array comprising a plurality of transducer elements , the method comprising: (a) determining relative locations of the plurality of transducer arrays with respect to one another and the connecting frame ; (b) determining a location of the connecting frame relative to an anatomic region of interest ; (c) determining a spatial arrangement of the transducer elements in each transducer array with respect to the anatomic region of interest based on steps (a) and (b); and (d) based on the determination in step (c), adjusting a transmission configuration of the transducer elements in the plurality of transducer arrays to achieve a desired focusing property with respect to the anatomic region of interest while maintaining coherence therebetween. (a) determining relative locations of the plurality of transducer arrays with respect to one another and the connecting frame ; (b) determining a location of the connecting frame relative to an anatomic region of interest ; (c) determining a spatial arrangement of the transducer elements in each transducer array with respect to the anatomic region of interest based on steps (a) and (b); and (d) based on the determination in step (c), adjusting a transmission configuration of the transducer elements in the plurality of transducer arrays to achieve a desired focusing property with respect to the anatomic region of interest while maintaining coherence therebetween.
Method of providing an assembled image using a digital microscope , the digital microscope comprising an optical system having an objective revolver equipped with a plurality of microscope objectives , an image sensor having a predefined number of image pixels, and a stage for holding a sample , the stage being movable in relation to the optical system and the image sensor , the method comprising: receiving a user selection regarding an area of interest of the sample , the user selection being indicative of the position and extension of the area of interest ; depending on the user selection, selecting a particular one of the plurality of microscope objectives and controlling the objective revolver to place the particular one of the plurality of microscope objectives into an optical path of the optical system ; depending on the user selection and the selected particular one of the plurality of microscope objectives , selecting one of a full resolution mode and a reduced resolution mode; moving the stage with respect to the optical system and the image sensor , and generating individual images of the area of interest , wherein the individual images are generated with the predefined number of image pixels in the full resolution mode and wherein the individual images are generated with a reduced number of image pixels, as compared to the predefined number of image pixels, in the reduced resolution mode; and combining the individual images into the assembled image, representing the area of interest . receiving a user selection regarding an area of interest of the sample , the user selection being indicative of the position and extension of the area of interest ; depending on the user selection, selecting a particular one of the plurality of microscope objectives and controlling the objective revolver to place the particular one of the plurality of microscope objectives into an optical path of the optical system ; depending on the user selection and the selected particular one of the plurality of microscope objectives , selecting one of a full resolution mode and a reduced resolution mode; moving the stage with respect to the optical system and the image sensor , and generating individual images of the area of interest , wherein the individual images are generated with the predefined number of image pixels in the full resolution mode and wherein the individual images are generated with a reduced number of image pixels, as compared to the predefined number of image pixels, in the reduced resolution mode; and combining the individual images into the assembled image, representing the area of interest .
A safety controller for the safety-directed monitoring and control of a machine , said safety controller comprising at least one monitoring input which is configured to receive a detection signal (DS) from a protective device ; at least one control output which is configured to output a shutdown command to the machine to be monitored and controlled; at least one bypass input which is configured to receive a bypass demand from an independent control system ; and an evaluation unit which is connected to the monitoring input , to the bypass input , and to the control output and which is configured to generate the shutdown command on the basis of a received detection signal, wherein the safety controller is operated in a bypass mode for a predefinable bypass time period divided into one or more part time periods after the reception of a bypass demand, with no shutdown command being output in the bypass mode at least during a part time period even on a reception of a detection signal; wherein at least one configuration input is provided which is connected to the evaluation unit and which is configured to receive a respective configuration signal; wherein the evaluation unit is configured to determine the bypass time period and/or at least a part time period of the bypass time period on the basis of the received configuration signal; and wherein the evaluation unit is configured to determine a failure state when an expected detection signal was not received within the bypass time period and/or within at least a part time period and/or an expected ending of a reception of a detection signal or of a bypass demand has not taken place, characterized in that one of the part time periods is a predefinable first latency time period (L1) within which a detection signal has to be received so that no failure state is determined, with the evaluation unit being configured to determine the first latency time period (L1) on the basis of the received configuration signal; and/or in that one of the part time periods is a predefinable detection time period (D) for which a previously received detection signal has to last so that no failure state is determined, with the evaluation unit being configured to determine the detection time period on the basis of the received configuration signal; and in that one of the part time periods is a predefinable third latency time period (L3) within which the reception of the bypass demand has to have ended after the ending of the operation of the safety controller in the bypass mode so that no failure state is determined, with the evaluation unit being configured to determine the third latency time period (L3) on the basis of the received configuration signal.
An aircraft storage bin comprising, an upper housing , and a bucket movable with respect to the upper housing between a closed position and an open position, wherein the upper housing and the bucket cooperate to define a bin interior , wherein the bucket includes a bottom , a back , and first and second opposing side walls , wherein the bottom includes an outer surface , an inner surface , a front edge , and first and second protrusions protruding into the bin interior, wherein the first protrusion defines a first luggage engaging surface and the second protrusion defines a second luggage engaging surface , characterised in that the first protrusion includes an outer surface , wherein the outer surface of the first protrusion defines a channel , wherein the channel includes at least a portion of a latch button assembly disposed therein, wherein first and second cables extend outwardly from the latch button assembly and through the channel, and wherein the bucket includes a cover strip on the outer surface of the bucket that partially defines the channel together with the outer surface of the first protrusion. an upper housing , and a bucket movable with respect to the upper housing between a closed position and an open position, wherein the upper housing and the bucket cooperate to define a bin interior , wherein the bucket includes a bottom , a back , and first and second opposing side walls , wherein the bottom includes an outer surface , an inner surface , a front edge , and first and second protrusions protruding into the bin interior, wherein the first protrusion defines a first luggage engaging surface and the second protrusion defines a second luggage engaging surface , characterised in that the first protrusion includes an outer surface , wherein the outer surface of the first protrusion defines a channel , wherein the channel includes at least a portion of a latch button assembly disposed therein, wherein first and second cables extend outwardly from the latch button assembly and through the channel, and wherein the bucket includes a cover strip on the outer surface of the bucket that partially defines the channel together with the outer surface of the first protrusion.
A cooking system comprising: a housing defining a hollow chamber configured to receive food in a cooking enclosure, said housing having an upper portion defining an opening to said hollow chamber; a lid movable relative to said housing between an open position and a closed position; a lid lock associated with at least one of said lid and said housing , said lid being configurable between a lid locked condition with said housing and a lid unlocked condition with said housing via said lid lock ; and an air movement mechanism 78 operable to circulate air within the cooking enclosure; wherein the cooking system is operable selectively to perform each of a dry cooking operation, and a pressure cooking operation; wherein, in the dry cooking operation, air and moisture are actively exhausted or vented from the cooking enclosure to outside the cooking system ; and further including an inlet vent and an outlet vent disposed in said lid , wherein the inlet and outlet vents are configurable between an open vent condition and a closed vent condition via actuation of said lid lock ; wherein the cooking system is operable to perform the dry cooking operation when the inlet and outlet vents are in said open vent condition, and to perform the pressure cooking operation when the inlet and outlet vents are in said closed vent condition; wherein the cooking system is configured, in the open vent condition, to cause fluid to flow into the cooking enclosure via the inlet vent , and to be expelled from the cooking enclosure via the outlet vent . a housing defining a hollow chamber configured to receive food in a cooking enclosure, said housing having an upper portion defining an opening to said hollow chamber; a lid movable relative to said housing between an open position and a closed position; a lid lock associated with at least one of said lid and said housing , said lid being configurable between a lid locked condition with said housing and a lid unlocked condition with said housing via said lid lock ; and an air movement mechanism 78 operable to circulate air within the cooking enclosure; wherein the cooking system is operable selectively to perform each of a dry cooking operation, and a pressure cooking operation; a dry cooking operation, and a pressure cooking operation; wherein, in the dry cooking operation, air and moisture are actively exhausted or vented from the cooking enclosure to outside the cooking system ; and further including an inlet vent and an outlet vent disposed in said lid , wherein the inlet and outlet vents are configurable between an open vent condition and a closed vent condition via actuation of said lid lock ; wherein the cooking system is operable to perform the dry cooking operation when the inlet and outlet vents are in said open vent condition, and to perform the pressure cooking operation when the inlet and outlet vents are in said closed vent condition; wherein the cooking system is configured, in the open vent condition, to cause fluid to flow into the cooking enclosure via the inlet vent , and to be expelled from the cooking enclosure via the outlet vent .
A method of selectively modifying a T cell population comprising: (a) forming T cell-targeted synthetic nanocarriers utilizing a process comprising: adding antibody-functionalized polyglutamic acid (PGA) that selectively binds the T cell population to nucleic acid encapsulated within a positively-charged polymer carrier, thereby forming the T cell-targeted synthetic nanocarriers, wherein the T cell-targeted synthetic nanocarriers comprise: (A) nucleic acid encapsulated within the positively-charged polymer carrier, wherein the nucleic acid encodes a gene editing agent or a phenotype-altering protein; (B) a neutrally or negatively-charged coating comprising the PGA on the outer surface of the positively-charged polymer carrier; and (C) the antibody extending from the outer surface of the neutrally or negatively-charged coating and linked to the PGA within the neutrally or negatively-charged coating; and (b) administering the formed T cell-targeted synthetic nanocarriers to a heterogenous mixture of ex vivo cells comprising the T cell population thereby selectively modifying the T cell population. (a) forming T cell-targeted synthetic nanocarriers utilizing a process comprising: adding antibody-functionalized polyglutamic acid (PGA) that selectively binds the T cell population to nucleic acid encapsulated within a positively-charged polymer carrier, thereby forming the T cell-targeted synthetic nanocarriers, wherein the T cell-targeted synthetic nanocarriers comprise: (A) nucleic acid encapsulated within the positively-charged polymer carrier, wherein the nucleic acid encodes a gene editing agent or a phenotype-altering protein; (B) a neutrally or negatively-charged coating comprising the PGA on the outer surface of the positively-charged polymer carrier; and (C) the antibody extending from the outer surface of the neutrally or negatively-charged coating and linked to the PGA within the neutrally or negatively-charged coating; and (A) nucleic acid encapsulated within the positively-charged polymer carrier, wherein the nucleic acid encodes a gene editing agent or a phenotype-altering protein; (B) a neutrally or negatively-charged coating comprising the PGA on the outer surface of the positively-charged polymer carrier; and (C) the antibody extending from the outer surface of the neutrally or negatively-charged coating and linked to the PGA within the neutrally or negatively-charged coating; and (b) administering the formed T cell-targeted synthetic nanocarriers to a heterogenous mixture of ex vivo cells comprising the T cell population thereby selectively modifying the T cell population.
An in vitro method for the prognosis of patients for progression of a cancer, which method comprises the following steps: a) quantifying, in a tumor tissue sample from said patient, at least two biological markers indicative of the status of the adaptive immune response of said patient against cancer; and b) comparing the value obtained at step a) for said at least two biological markers with a predetermined reference value for the same biological markers; which predetermined reference value is correlated with a specific prognosis of progression of said cancer, wherein said at least two biological markers comprise PDCD1LG1 and CXCL9. a) quantifying, in a tumor tissue sample from said patient, at least two biological markers indicative of the status of the adaptive immune response of said patient against cancer; and b) comparing the value obtained at step a) for said at least two biological markers with a predetermined reference value for the same biological markers; which predetermined reference value is correlated with a specific prognosis of progression of said cancer, wherein said at least two biological markers comprise PDCD1LG1 and CXCL9.