mhurhangee/patent-ind-claim-en huggingface dataset:
An apparatus for at least partially supporting a leaflet of a regurgitant heart valve, the apparatus comprising at least one subvalvular device defining a longitudinal axis and including: a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface , a supporter perimeter wall extending longitudinally between, and integrally and contiguously formed with both of, the upper and lower supporter surfaces , at least a portion of the supporter perimeter wall being configured to contact a subvalvular cardiac wall adjacent to the heart valve; an anchor portion adjacent to, and longitudinally spaced from, the upper supporter surface , the anchor portion including a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface , an anchor perimeter wall extending longitudinally between, and integrally and contiguously formed with both of, the upper and lower anchor surfaces (218 and 216); and a connector neck interposed longitudinally between, and directly attached to both of, the upper supporter surface and the lower anchor surface , the connector neck being configured to penetrate longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site; wherein the subvalvular supporting portion , anchor portion , and connector neck collectively enclose a single contiguous interior volume. a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface , a supporter perimeter wall extending longitudinally between, and integrally and contiguously formed with both of, the upper and lower supporter surfaces , at least a portion of the supporter perimeter wall being configured to contact a subvalvular cardiac wall adjacent to the heart valve; an anchor portion adjacent to, and longitudinally spaced from, the upper supporter surface , the anchor portion including a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface , an anchor perimeter wall extending longitudinally between, and integrally and contiguously formed with both of, the upper and lower anchor surfaces (218 and 216); and a connector neck interposed longitudinally between, and directly attached to both of, the upper supporter surface and the lower anchor surface , the connector neck being configured to penetrate longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site; wherein the subvalvular supporting portion , anchor portion , and connector neck collectively enclose a single contiguous interior volume.
A method for performing a digital signature using a one-way function in a zero-knowledge proof, performed by a processor in a device , the method comprising: calculating a second bit stream from one or more first substitution-boxes, S-boxes, by an input bit stream of the digital signature based on a first bit stream ; and calculating a third bit stream by inputting the second bit stream to a processing matrix ; characterized by calculating a fourth bit stream by parallelly inputting an input based on the third bit stream to two or more second S-boxes . calculating a second bit stream from one or more first substitution-boxes, S-boxes, by an input bit stream of the digital signature based on a first bit stream ; and calculating a third bit stream by inputting the second bit stream to a processing matrix ; characterized by calculating a fourth bit stream by parallelly inputting an input based on the third bit stream to two or more second S-boxes .
A method for manufacturing a leaktight assembly wherein: - a bag comprising a wall of flexible film is provided, the wall of said bag defining an internal volume (V) of said bag, said bag having two opposite ends, a first access opening at the first end adapted for placing the internal volume of the bag in communication with the outside of the bag, a second access opening at the second end adapted for placing the internal volume of the bag in communication with the outside of the bag, - a connection system is provided, the connection system comprising a connector adapted for mechanical connection to a complementary connector of a sterile chamber in order to establish a sterile communication between the bag and the chamber , the connector comprising a portion for attachment to the bag, characterized in that the connection system further comprises an overmolding molded over the attachment portion and chosen from a suitable material allowing the welding of the bag wall to the overmolding , the manufacturing method further comprising the steps of: - positioning the wall of the bag facing the overmolding at the first access opening , the attachment portion surrounding a space for passage between the bag and the chamber at said first access opening , - welding the wall of the bag to the overmolding in a closed continuous manner all along the first access opening at a temperature allowing the wall of the bag and the overmolding to melt without the connector melting. - a bag comprising a wall of flexible film is provided, the wall of said bag defining an internal volume (V) of said bag, said bag having two opposite ends, a first access opening at the first end adapted for placing the internal volume of the bag in communication with the outside of the bag, a second access opening at the second end adapted for placing the internal volume of the bag in communication with the outside of the bag, - a connection system is provided, the connection system comprising a connector adapted for mechanical connection to a complementary connector of a sterile chamber in order to establish a sterile communication between the bag and the chamber , the connector comprising a portion for attachment to the bag, characterized in that the connection system further comprises an overmolding molded over the attachment portion and chosen from a suitable material allowing the welding of the bag wall to the overmolding , - positioning the wall of the bag facing the overmolding at the first access opening , the attachment portion surrounding a space for passage between the bag and the chamber at said first access opening , - welding the wall of the bag to the overmolding in a closed continuous manner all along the first access opening at a temperature allowing the wall of the bag and the overmolding to melt without the connector melting.
Ocrelizumab for use in the treatment of multiple sclerosis in a patient, wherein an effective amount of ocrelizumab is administered to the patient to provide an initial ocrelizumab exposure of 0.6 grams followed by a second ocrelizumab exposure of 0.6 grams, wherein the initial ocrelizumab exposure comprises a first dose and a second dose of ocrelizumab, wherein the first dose and second dose of ocrelizumab are each 0.3 grams, wherein the second dose is administered 14 days after the first dose, wherein the second ocrelizumab exposure is provided approximately 24 weeks after the initial exposure, and wherein the second ocrelizumab exposure comprises a single dose of ocrelizumab, wherein the single dose of ocrelizumab is 0.6 grams.
An aerosol delivery device comprising: - an aerosol generator for generating an aerosol in the aerosol delivery device , - a sensor configured to detect a use of the aerosol delivery device for aerosol treatment, and - a controller configured to deactivate the aerosol generator if no use of the aerosol delivery device for aerosol treatment is detected by the sensor , characterized in that the controller is configured to deactivate the aerosol generator after the lapse of a period of time if no use of the aerosol delivery device for aerosol treatment is detected by the sensor , the controller is configured to deactivate the aerosol generator only if no use of the aerosol delivery device for aerosol treatment is detected by the sensor , wherein the sensor is configured to detect that the aerosol delivery device is not being used for aerosol treatment only if no respiration of a user, including inhalation and exhalation, through the aerosol delivery device is sensed by the sensor , and the aerosol generator is a continuous aerosol generator. - an aerosol generator for generating an aerosol in the aerosol delivery device , - a sensor configured to detect a use of the aerosol delivery device for aerosol treatment, and - a controller configured to deactivate the aerosol generator if no use of the aerosol delivery device for aerosol treatment is detected by the sensor ,
A system for detecting operating activities of at least one ancillary unit for an agricultural working machine , wherein the system has a device for detecting operating status data at least of the at least one ancillary unit , wherein arranged on the working machine and/or the at least one ancillary unit is at least one transmitting module which actively transmits operating status data at intervals and the transmitted operating status data of which can be received and recorded by a device in the form of a mobile data receiving unit for wirelessly detecting operating status data, wherein the transmitting module is in the form of a beacon including a battery and the transmitting module includes at least one sensor integrated therein for determining a physical property of the working machine or the ancillary unit .
A method for the early detection of breast cancer comprising: (a) detecting and quantifying the presence of markers 8-OHDG, NSE, NGAL, CA 15.3 and EGFR in blood or urine; (b) establishing the probability of breast cancer affectation according to a logistic regression of the values detected and quantified in blood or urine of a combination of the markers 8-OHDG, EGFR, NSE, CA 15.3 and NGAL; and wherein the calculus of the probability of breast cancer affectation comprises: (i) the calculation of the ratio of the values detected and quantified of the marker 8-OHDG with respect to the values detected and quantified in of the marker EGFR; (ii) the product of the ratio (8-OHDG/EGFR) in step (i) by the value detected and quantified of the marker NGAL; and (iii) the calculation of the product of the values detected and quantified of the markers NGAL and CA 15.3; and wherein the logistic regression of the values detected and quantified in blood or urine of a combination of the markers 8-OHDG, EGFR, NSE, CA 15.3 and NGAL is calculated according with the following formula: Logit = − 5.634 + 5.125 ∗ RATIO 8 − OHDG EGFR − 0.282 ∗ NSE − 0.471 ∗ RATIO 8 − OHDG EGFR ∗ NGAL + 0.4 ∗ NGAL ∗ CA 153 P = e Logit 1 + e Logit ∗ 100
Device for stabilising body joints, comprising: a receptacle , wherein the receptacle is filled with a filling medium , a first body for interaction with the filling medium , wherein the first body is arranged displaceably in the receptacle , and wherein the filling medium is a fluid, a force-transmission means for the transmission of an external force onto the first body , a second body for interacting with the filling medium , which second body is arranged displaceably in the receptacle , wherein the second body is coupled elastically to the first body via a coupling element , wherein the second body and/or the first body have at least one outlet opening through which the filling medium can flow, and wherein the first body forms a valve body and the second body forms a valve seat, so that a flow of the filling medium through the outlet opening can be allowed or prevented as a function of the valve position, characterized in that , the size of a shear surface of the first body , and the size of a shear surface of the second body are configured in such a manner that, if the external force acts with a speed below a threshold value on the first body , the first body and the second body can be moved almost uniformly through the filling medium , and that, if the external force acts with a speed greater than or equal to the threshold value on the first body , the first body and the second body can be moved relative to one another so that the valve position is affected. a receptacle , wherein the receptacle is filled with a filling medium , a first body for interaction with the filling medium , wherein the first body is arranged displaceably in the receptacle , and wherein the filling medium is a fluid, a force-transmission means for the transmission of an external force onto the first body , a second body for interacting with the filling medium , which second body is arranged displaceably in the receptacle , wherein the second body is coupled elastically to the first body via a coupling element , wherein the second body and/or the first body have at least one outlet opening through which the filling medium can flow, and wherein the first body forms a valve body and the second body forms a valve seat, so that a flow of the filling medium through the outlet opening can be allowed or prevented as a function of the valve position, characterized in that , the size of a shear surface of the first body , and the size of a shear surface of the second body are configured in such a manner that, if the external force acts with a speed below a threshold value on the first body , the first body and the second body can be moved almost uniformly through the filling medium , and that, if the external force acts with a speed greater than or equal to the threshold value on the first body , the first body and the second body can be moved relative to one another so that the valve position is affected.
Solder-joint-forming solder paste adapted for soldering of a substrate, the solder paste comprising: a metal powder component comprising: an intermetallic compound powder consisting of Cu and Sn, and including Cu 3 Sn, with a mass ratio of Sn to Cu within a range of 8:2 to 2:8; and a Sn-Bi solder powder containing, as a main component, Sn, and a flux component, characterized in that 50 to 70% by mass of the intermetallic compound powder consisting of Cu and Sn and 30 to 50% by mass of the solder powder containing, as a main component, Sn are contained in the metal powder component, wherein the metal powder component has an average particle size of 50 μm or less, and wherein the solder powder has an Sn content of 40% by mass or more and, optionally, one or more elements selected from Ag, Cu, In, Ni, Co, Sb, Ge, Ga, P, Fe, Zn, Al and Ti, in a content of each element of 5% by mass or less, and wherein the solder-joint forming solder paste comprises 80 to 90% by mass of the metal powder component and 10 to 20% by mass of the flux component. a metal powder component comprising: an intermetallic compound powder consisting of Cu and Sn, and including Cu 3 Sn, with a mass ratio of Sn to Cu within a range of 8:2 to 2:8; and a Sn-Bi solder powder containing, as a main component, Sn, and an intermetallic compound powder consisting of Cu and Sn, and including Cu 3 Sn, with a mass ratio of Sn to Cu within a range of 8:2 to 2:8; and a Sn-Bi solder powder containing, as a main component, Sn, and a flux component, characterized in that 50 to 70% by mass of the intermetallic compound powder consisting of Cu and Sn and 30 to 50% by mass of the solder powder containing, as a main component, Sn are contained in the metal powder component, wherein the metal powder component has an average particle size of 50 μm or less, and wherein the solder powder has an Sn content of 40% by mass or more and, optionally, one or more elements selected from Ag, Cu, In, Ni, Co, Sb, Ge, Ga, P, Fe, Zn, Al and Ti, in a content of each element of 5% by mass or less, and 50 to 70% by mass of the intermetallic compound powder consisting of Cu and Sn and 30 to 50% by mass of the solder powder containing, as a main component, Sn are contained in the metal powder component, wherein the metal powder component has an average particle size of 50 μm or less, and wherein the solder powder has an Sn content of 40% by mass or more and, optionally, one or more elements selected from Ag, Cu, In, Ni, Co, Sb, Ge, Ga, P, Fe, Zn, Al and Ti, in a content of each element of 5% by mass or less, and wherein the solder-joint forming solder paste comprises 80 to 90% by mass of the metal powder component and 10 to 20% by mass of the flux component.
An apparatus , comprising: a laser configured to pulse laser light illuminating at least one object; a digital micro-mirror device oriented to receive laser light reflected from the at least one object and including an array of mirrors each of which may be selectively controlled to be oriented in one of a first direction and a second direction; a detector positioned so that mirrors within the digital micro-mirror device oriented in the first direction reflect incident light onto the detector and mirrors within the digital micro-mirror device oriented in the second direction do not, the detector configured to output a signal representative of an amount of light incident on the detector; and a control system configured to apply M spatial patterns to the mirrors of the digital micro-mirror device, each of the M spatial patterns in synchronization with a corresponding pulse from the laser, and, for each of the M spatial patterns, to store sampled signal values from the output of the detector at each of K times following the corresponding pulse from the laser, characterised in that the control system includes a processing system configured to reconstruct K images of the at least one object each using all M spatial patterns and stored sampled signal values corresponding to a respective one of the K times, wherein the processing system is configured to search the K images for an object of interest among objects including the at least one object. a laser configured to pulse laser light illuminating at least one object; a digital micro-mirror device oriented to receive laser light reflected from the at least one object and including an array of mirrors each of which may be selectively controlled to be oriented in one of a first direction and a second direction; a detector positioned so that mirrors within the digital micro-mirror device oriented in the first direction reflect incident light onto the detector and mirrors within the digital micro-mirror device oriented in the second direction do not, the detector configured to output a signal representative of an amount of light incident on the detector; and a control system configured to apply M spatial patterns to the mirrors of the digital micro-mirror device, each of the M spatial patterns in synchronization with a corresponding pulse from the laser, and, for each of the M spatial patterns, to store sampled signal values from the output of the detector at each of K times following the corresponding pulse from the laser, characterised in that the control system includes a processing system configured to reconstruct K images of the at least one object each using all M spatial patterns and stored sampled signal values corresponding to a respective one of the K times, wherein the processing system is configured to search the K images for an object of interest among objects including the at least one object.
A cleaning composition comprising: (a) a variant of a parent alpha-amylase wherein the parent alpha-amylase is an alpha-amylase which has the amino acid sequence shown in SEQ ID NO: 6 and the variant is a polypeptide having amylolytic activity and an amino acid sequence having at least 85% identity with the mature polypeptide of SEQ ID NO: 6 and comprises a substitution at one or more positions selected from the group consisting of 195, 193, 197, 198, 200, 203, 206, 210, 212, 213 and 243, wherein the parent alpha-amylase sequence is modified by substitution at position 206 to Y, using the numbering according to SEQ ID NO: 6; and (b) a cleaning adjunct, preferably in an amount from 0.01 to 99.9 wt%; and (c) at least one chelating agent wherein said chelating agent at a concentration below 10 mM is capable of reducing the concentration of free calcium ions from 2.0 mM to 0.10 mM when measured at 21°C and pH 8.0. (a) a variant of a parent alpha-amylase wherein the parent alpha-amylase is an alpha-amylase which has the amino acid sequence shown in SEQ ID NO: 6 and the variant is a polypeptide having amylolytic activity and an amino acid sequence having at least 85% identity with the mature polypeptide of SEQ ID NO: 6 and comprises a substitution at one or more positions selected from the group consisting of 195, 193, 197, 198, 200, 203, 206, 210, 212, 213 and 243, wherein the parent alpha-amylase sequence is modified by substitution at position 206 to Y, using the numbering according to SEQ ID NO: 6; and (b) a cleaning adjunct, preferably in an amount from 0.01 to 99.9 wt%; and (c) at least one chelating agent wherein said chelating agent at a concentration below 10 mM is capable of reducing the concentration of free calcium ions from 2.0 mM to 0.10 mM when measured at 21°C and pH 8.0.
(S)-7-(2-Methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-y1)-1H-pyrazolo[4,3-c]quinolin-4 -one represented by formula (I) or a pharmaceutically acceptable salt thereof for use in treating dementia with Lewy bodies.
A meat replica composition comprising: (a) 5% to 88% by weight of a meat dough, wherein said meat dough comprises an isolated plant protein and an edible fibrous component; (b) 0% to 40% by weight of a carbohydrate-based gel; (c) 5% to 35% by weight of a non-animal fat; (d) 0.00001% to 10% by weight of a flavoring agent selected from a cucumber extract or a melon extract; (e) 0% to 15% by weight of a binding agent; and (f) 0.01% to 4% by weight of a heme-containing protein and/or an iron salt. (a) 5% to 88% by weight of a meat dough, wherein said meat dough comprises an isolated plant protein and an edible fibrous component; (b) 0% to 40% by weight of a carbohydrate-based gel; (c) 5% to 35% by weight of a non-animal fat; (d) 0.00001% to 10% by weight of a flavoring agent selected from a cucumber extract or a melon extract; (e) 0% to 15% by weight of a binding agent; and (f) 0.01% to 4% by weight of a heme-containing protein and/or an iron salt.
A working fluid composition for a refrigerating machine, comprising: a refrigerant comprising a first refrigerant component and a second refrigerant component, and having a global warming potential (GWP) of 500 or less, wherein the first refrigerant component is at least one selected from difluoromethane and tetrafluoropropene, and the second refrigerant component is at least one selected from carbon dioxide and a hydrocarbon having 3 to 4 carbon atoms and the sum of the first refrigerant and the second refrigerant is 80% by mass or more based on the total amount of the refrigerant; and a refrigerating machine oil comprising at least one selected from a polyol ester, a polyvinyl ether and a polyalkylene glycol compound as a base oil, wherein a carbon/oxygen molar ratio of the polyol ester is from 3.2 to 5.0, a carbon/oxygen molar ratio of the polyvinyl ether is from 3.2 to 5.8 and a carbon/oxygen molar ratio of the polyalkylene glycol compound is from 2.5 to 4.0. a refrigerant comprising a first refrigerant component and a second refrigerant component, and having a global warming potential (GWP) of 500 or less, wherein the first refrigerant component is at least one selected from difluoromethane and tetrafluoropropene, and the second refrigerant component is at least one selected from carbon dioxide and a hydrocarbon having 3 to 4 carbon atoms and the sum of the first refrigerant and the second refrigerant is 80% by mass or more based on the total amount of the refrigerant; and a refrigerating machine oil comprising at least one selected from a polyol ester, a polyvinyl ether and a polyalkylene glycol compound as a base oil, wherein a carbon/oxygen molar ratio of the polyol ester is from 3.2 to 5.0, a carbon/oxygen molar ratio of the polyvinyl ether is from 3.2 to 5.8 and a carbon/oxygen molar ratio of the polyalkylene glycol compound is from 2.5 to 4.0.