A compound of the formula wherein each X is independently O or S; One of R 1 and R 2 is And the other one is Z 1 is N or CR a ; R a is H, halogen, C 1-6 alkyl substituted with 0-6 R 5 , C 3-6 cycloalkyl substituted with 0-6 R 5 , CN, NO 2 , OH, OR a1 , SR a1 , -C(O)NR a1 R a1 , -COOR a1 , -OC(O)R a1 , - OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , - NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , -S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R a1 is H or C 1-3 alkyl substituted with 0-6 R 5 ; R 3 and R 4 are independently H, CH 3 , and halogen, NH 2 or OH; R 3a and R 4a are independently H, CH 3 , halogen, NH 2 or OH; R 5 is H, halogen, C 1-3 alkyl substituted with 0-6 R a , C 3-6 cycloalkyl substituted with 0-6 R a , aryl substituted with 0-6 R a or heteroaryl substituted with 0-6 R a , CN, NO 2 , OH, OR al , SR al , -C(O)NR al R al , -COOR al , -OC(O)R al , -OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , -NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , - S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R 8 is H, halogen, C 1-3 alkyl substituted with 0-6 R 5 , CN, NO 2 , OH, OR al , SR al , - C(O)NR a1 R a1 , -COOR al , -OC(O)R al , -OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , -NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , -S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R 9 is H, C 1-6 alkyl substituted with 0-6 R 5 , C 3-6 cycloalkyl substituted with 0-6 R 5 , aryl substituted with 0-6 R 5 or heteroaryl substituted with 0-6 R 5 ; Y is CR 5 or N; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. each X is independently O or S; One of R 1 and R 2 is And the other one is Z 1 is N or CR a ; R a is H, halogen, C 1-6 alkyl substituted with 0-6 R 5 , C 3-6 cycloalkyl substituted with 0-6 R 5 , CN, NO 2 , OH, OR a1 , SR a1 , -C(O)NR a1 R a1 , -COOR a1 , -OC(O)R a1 , - OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , - NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , -S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R a1 is H or C 1-3 alkyl substituted with 0-6 R 5 ; R 3 and R 4 are independently H, CH 3 , and halogen, NH 2 or OH; R 3a and R 4a are independently H, CH 3 , halogen, NH 2 or OH; R 5 is H, halogen, C 1-3 alkyl substituted with 0-6 R a , C 3-6 cycloalkyl substituted with 0-6 R a , aryl substituted with 0-6 R a or heteroaryl substituted with 0-6 R a , CN, NO 2 , OH, OR al , SR al , -C(O)NR al R al , -COOR al , -OC(O)R al , -OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , -NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , - S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R 8 is H, halogen, C 1-3 alkyl substituted with 0-6 R 5 , CN, NO 2 , OH, OR al , SR al , - C(O)NR a1 R a1 , -COOR al , -OC(O)R al , -OC(O)NR a1 R a1 , -NR a1 R a1 , -NR a1 C(O)R a1 , - NR a1 COOR a1 , -NR a1 C(O)NR a1 R a1 , -NR a1 S(O) 2 R a1 , -NR a1 S(O) 2 NR a1 R a1 , -S(O)R a1 , - S(O)NR a1 R a1 , -S(O) 2 R a1 or S(O) 2 NR a1 R a1 ; R 9 is H, C 1-6 alkyl substituted with 0-6 R 5 , C 3-6 cycloalkyl substituted with 0-6 R 5 , aryl substituted with 0-6 R 5 or heteroaryl substituted with 0-6 R 5 ; Y is CR 5 or N; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. <EOS>