mhurhangee/patent-ind-claim-en huggingface dataset:
A composition for use in treating Duchenne Muscular Dystrophy associated with a reading frame shift in a dystrophin gene in a subject in need thereof, the composition comprising: (i) a first nuclease that cuts a first recognition sequence or RNA or DNA encoding said first nuclease; and (ii) a second nuclease that cuts a second recognition sequence or RNA or DNA encoding said second nuclease; wherein said first recognition sequence is within an intron that is adjacent to and 5' upstream of a first exon in the dystrophin gene of a muscle cell of said subject; wherein said second recognition sequence is within an intron that is adjacent to and 3' downstream of said first exon in the dystrophin gene of a muscle cell of said subject; wherein said first recognition sequence and said second recognition sequence have complementary overhangs when cut by said first nuclease and said second nuclease; and wherein said first nuclease and said second nuclease are capable of removing said first exon from said dystrophin gene in said muscle cell such that the normal reading frame of said dystrophin gene is restored. (i) a first nuclease that cuts a first recognition sequence or RNA or DNA encoding said first nuclease; and (ii) a second nuclease that cuts a second recognition sequence or RNA or DNA encoding said second nuclease;
A Hybrid Automatic Repeat Request, HARQ, sending method, comprising: detecting (S102) a receiving condition of N transmission blocks; judging whether k falls within a preset value range, wherein k is a number of transmission blocks which are correctly received in received transmission blocks; when it is judged that k falls within the preset value range, generating (S104) a first HARQ state value with a length of M bits according to the receiving condition, wherein the first HARQ state value has a plurality of optional values, each corresponding to a respective receiving condition of the N transmission blocks when k falls within the preset value range, M , N and k are integers, 2 ≤ M < N , and 0≤ k ≤ N ; and sending (S106) the first HARQ state value as HARQ information; when it is judged that k does not fall within the preset value range, generating a second HARQ state value with a length of W bits according to the receiving condition, wherein at least one value in all values of the second HARQ state value is adopted to represent at least two receiving conditions of the N transmission blocks when k does not fall within the preset value range, and 2≤ W ≤ M ; and sending the second HARQ state value as the HARQ information. detecting (S102) a receiving condition of N transmission blocks; judging whether k falls within a preset value range, wherein k is a number of transmission blocks which are correctly received in received transmission blocks; when it is judged that k falls within the preset value range, generating (S104) a first HARQ state value with a length of M bits according to the receiving condition, wherein the first HARQ state value has a plurality of optional values, each corresponding to a respective receiving condition of the N transmission blocks when k falls within the preset value range, M , N and k are integers, 2 ≤ M < N , and 0≤ k ≤ N ; and sending (S106) the first HARQ state value as HARQ information; when it is judged that k does not fall within the preset value range, generating a second HARQ state value with a length of W bits according to the receiving condition, wherein at least one value in all values of the second HARQ state value is adopted to represent at least two receiving conditions of the N transmission blocks when k does not fall within the preset value range, and 2≤ W ≤ M ; and sending the second HARQ state value as the HARQ information.
A vacuum cleaner nozzle with a suction head , with a suction mouth , which is arranged on the underside of the suction head and which adjoins a suction channel arranged in the suction head , wherein the suction mouth extends in a transverse direction (y) and is limited by a front suction mouth edge in a working direction (x) and a rear suction mouth edge in a working direction (x), and with a suction connecting fitting , which is arranged behind the suction mouth in the working direction (x) and which is fluidically connected to the suction channel , and wherein the suction connecting fitting is articulated on the suction head about a pivot axis (s), which runs through the suction head in the transverse direction (y), wherein the pivot axis (s) can be displaced on the suction head between a front upper position (first position) and a lower rear position (second position), characterized in that the pivot axis (s) can be pivoted between the first position and the second position by means of a toggle lever .
A method in a terminal for authorizing storage of security keys, the method comprising the steps of: detecting by the terminal a fault with a data session encrypted with a Perfect Forward Secrecy, PFS, encryption technique, the data session extending at least between the terminal and a data center gateway; responsive to detecting the fault, sending from the terminal to the gateway a message with an authorization of an user connected to the terminal to authorize the data center gateway to persistently store one or more security keys associated with the data session, in view of troubleshooting the fault. detecting by the terminal a fault with a data session encrypted with a Perfect Forward Secrecy, PFS, encryption technique, the data session extending at least between the terminal and a data center gateway; responsive to detecting the fault, sending from the terminal to the gateway a message with an authorization of an user connected to the terminal to authorize the data center gateway to persistently store one or more security keys associated with the data session, in view of troubleshooting the fault.
A modified-release formulation comprising a bovine intestinal alkaline phosphatase (blAP), and being in the form of a powder, comprising: 1-10% by weight bovine intestinal alkaline phosphatase (blAP), 80-95% by weight hypromellose acetate succinate (HPMCAS), 1-10% by weight buffer, 0.01-0.1% by weight zinc, 0.1-1% by weight magnesium stearate, 1-10% by weight protein stabilizer, wherein the formulation is suitable for compressing and releases a substantial amount of the bovine intestinal alkaline phosphatase (blAP) in the intestines. 1-10% by weight bovine intestinal alkaline phosphatase (blAP), 80-95% by weight hypromellose acetate succinate (HPMCAS), 1-10% by weight buffer, 0.01-0.1% by weight zinc, 0.1-1% by weight magnesium stearate, 1-10% by weight protein stabilizer, wherein the formulation is suitable for compressing and releases a substantial amount of the bovine intestinal alkaline phosphatase (blAP) in the intestines.
A (meth)acrylic composition MC1 comprising, a) 100 parts of a liquid (meth)acrylic syrup comprising a1) between 10wt% and 50wt% of a (meth)acrylic polymer (P1), and a2) between 50wt% and 90wt% of a (meth)acrylic monomer (M1) comprising only one (meth)acrylic function, and b) between 0.01 and 10phr by weight of a (meth)acrylic monomer (M2) comprising at least two (meth)acrylic functions; c) between 0.01 and 10phr of a (meth)acrylic monomer (M3) comprising only one (meth)acrylic function and the (meth)acrylic monomer (M3) is different from (meth)acrylic monomer (M1); d) from 0phr to 10phr by weight of a metal containing compound; e) from 0phr to 10phr by weight of a reducing agent f) from 0ppm and 20 000ppm of a tertiary amine; g) from 0phr and 5phr of a initiator to start the polymerization of the (meth)acrylic monomers (M1), (M2) and (M3); h) from 0ppm to 10 000ppm of a transfer agent; i) from 0ppm to 10 000ppm of an antioxidant; j) from 0ppm to 1 000ppm a radical scavenger; k) from 0ppm to 10 000ppm of a thermal stabilizing agent and l) from 0ppm to 10 000ppm of a light stabilizer; m)optionally an inorganic filler; characterized in that the (meth)acrylic monomer (M3) is chosen from methacrylic acid. a) 100 parts of a liquid (meth)acrylic syrup comprising a1) between 10wt% and 50wt% of a (meth)acrylic polymer (P1), and a2) between 50wt% and 90wt% of a (meth)acrylic monomer (M1) comprising only one (meth)acrylic function, and a1) between 10wt% and 50wt% of a (meth)acrylic polymer (P1), and a2) between 50wt% and 90wt% of a (meth)acrylic monomer (M1) comprising only one (meth)acrylic function, and b) between 0.01 and 10phr by weight of a (meth)acrylic monomer (M2) comprising at least two (meth)acrylic functions; c) between 0.01 and 10phr of a (meth)acrylic monomer (M3) comprising only one (meth)acrylic function and the (meth)acrylic monomer (M3) is different from (meth)acrylic monomer (M1); d) from 0phr to 10phr by weight of a metal containing compound; e) from 0phr to 10phr by weight of a reducing agent f) from 0ppm and 20 000ppm of a tertiary amine; g) from 0phr and 5phr of a initiator to start the polymerization of the (meth)acrylic monomers (M1), (M2) and (M3); h) from 0ppm to 10 000ppm of a transfer agent; i) from 0ppm to 10 000ppm of an antioxidant; j) from 0ppm to 1 000ppm a radical scavenger; k) from 0ppm to 10 000ppm of a thermal stabilizing agent and l) from 0ppm to 10 000ppm of a light stabilizer; m)optionally an inorganic filler;
Coating device for metal-coating of workpieces , comprising - a housing , which surrounds a working space , - a retaining apparatus for retaining at least one workpiece in the working space , - at least one deposition apparatus comprising a deposition nozzle for applying a metal powder to a workpiece surface to be coated, and a laser for locally melting the metal powder on the workpiece surface to form a coating, and - at least one movement apparatus , by means of which the at least one deposition apparatus can be moved relative to the workpiece surface during the coating, - wherein at least two deposition apparatuses are arranged in the working space of the housing , which apparatuses are designed to simultaneously apply and melt metal powder, characterised - in that the workpiece is rotatably mounted on the holding device , - in that each deposition apparatus can be moved relative to the workpiece surface by at least one movement device during coating, - in that at least one movement apparatus , which is arranged in part on the holding device for the workpiece, has a motor by means of which the workpiece can be set in a rotational movement, and - in that a control device is provided for the movement apparatus , with which the rotary movement of the workpiece on the holding device and the movement of the deposition apparatus relative to the workpiece can be controlled. - a housing , which surrounds a working space , - a retaining apparatus for retaining at least one workpiece in the working space , - at least one deposition apparatus comprising a deposition nozzle for applying a metal powder to a workpiece surface to be coated, and a laser for locally melting the metal powder on the workpiece surface to form a coating, and - at least one movement apparatus , by means of which the at least one deposition apparatus can be moved relative to the workpiece surface during the coating, - wherein at least two deposition apparatuses are arranged in the working space of the housing , which apparatuses are designed to simultaneously apply and melt metal powder, - in that the workpiece is rotatably mounted on the holding device , - in that each deposition apparatus can be moved relative to the workpiece surface by at least one movement device during coating, - in that at least one movement apparatus , which is arranged in part on the holding device for the workpiece, has a motor by means of which the workpiece can be set in a rotational movement, and - in that a control device is provided for the movement apparatus , with which the rotary movement of the workpiece on the holding device and the movement of the deposition apparatus relative to the workpiece can be controlled.
A method of producing (+)-manool comprising: a) contacting geranylgeranyl diphosphate (GGPP) with a copalyl diphosphate (CPP) synthase to form a copalyl diphosphate, wherein the CPP synthase comprise an amino acid sequence having at least 90%, 95%, 98%, 99% or 100% sequence identity to SEQ ID NO: 14 or SEQ ID NO: 15; and b) contacting the CPP with a sclareol synthase to form (+)-manool, wherein the polypeptide having sclareol synthase activity comprises an amino acid sequence having at least 90%, 95%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 4 or SEQ ID NO: 5; and c) optionally isolating the (+)-manool. a) contacting geranylgeranyl diphosphate (GGPP) with a copalyl diphosphate (CPP) synthase to form a copalyl diphosphate, wherein the CPP synthase comprise an amino acid sequence having at least 90%, 95%, 98%, 99% or 100% sequence identity to SEQ ID NO: 14 or SEQ ID NO: 15; and b) contacting the CPP with a sclareol synthase to form (+)-manool, wherein the polypeptide having sclareol synthase activity comprises an amino acid sequence having at least 90%, 95%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 4 or SEQ ID NO: 5; and c) optionally isolating the (+)-manool.
A vacuum insulated heating assembly for a baked smoking set, comprising an outer tube and an inner tube ; the outer tube is fitted outside the inner tube , and two ends of the outer tube are fixed to an outer wall surface of the inner tube , a vacuum area is formed between an inner wall surface of the outer tube and the inner tube ; the inner tube comprises a tubular substrate , and a heating circuit formed on a surface of the tubular substrate so as to generate heat after electrification; and an axial position of the heating circuit on the tubular substrate is within an axial interval of the vacuum area , wherein the tubular substrate is made of a low heat conductive material, and the two ends of the outer tube are fixed with the inner tube using vacuum welding. the outer tube is fitted outside the inner tube , and two ends of the outer tube are fixed to an outer wall surface of the inner tube , a vacuum area is formed between an inner wall surface of the outer tube and the inner tube ; the inner tube comprises a tubular substrate , and a heating circuit formed on a surface of the tubular substrate so as to generate heat after electrification; and an axial position of the heating circuit on the tubular substrate is within an axial interval of the vacuum area , wherein the tubular substrate is made of a low heat conductive material, and the two ends of the outer tube are fixed with the inner tube using vacuum welding.
A medical device for modifying a left atrial appendage ("LAA") of a heart, the medical device comprising: an occluder portion including a proximal end and a distal end, the proximal end coupled to a hub , the occluder portion configured to move between an occluder-deployed state and an occluder-nondeployed state; and an anchor portion operably coupled to the occluder portion , the anchor portion configured to be moved between an anchor-deployed state and an anchor-nondeployed state, wherein the distal end of the occluder portion is distal of a distal end of the anchor portion when the anchor portion is in the anchor-nondeployed state; wherein the anchor portion comprises multiple anchor segments , each anchor segment including a first end and a second end with a loop portion therebetween, each of the first ends coupled to the hub and each of the second ends coupled together, characterised in that , the second ends are displaceable such that the anchor segments are moveable through the hub between the anchor deployed-state and the anchor non-deployed state. an occluder portion including a proximal end and a distal end, the proximal end coupled to a hub , the occluder portion configured to move between an occluder-deployed state and an occluder-nondeployed state; and an anchor portion operably coupled to the occluder portion , the anchor portion configured to be moved between an anchor-deployed state and an anchor-nondeployed state, wherein the distal end of the occluder portion is distal of a distal end of the anchor portion when the anchor portion is in the anchor-nondeployed state; wherein the anchor portion comprises multiple anchor segments , each anchor segment including a first end and a second end with a loop portion therebetween, each of the first ends coupled to the hub and each of the second ends coupled together, characterised in that , the second ends are displaceable such that the anchor segments are moveable through the hub between the anchor deployed-state and the anchor non-deployed state.
Device for demarcating, in one direction, referred to as the longitudinal direction, two parking spaces for motor vehicles in a covered space having a ground surface intended to accommodate said vehicles and a ceiling facing the ground surface, said device being characterized in that it comprises: - a flexible panel extending in said longitudinal direction corresponding to the direction for parking vehicles on both sides of the device, and comprising an upper edge and a lower edge oriented toward the ceiling and the ground surface , respectively, when said device is fixed to the ceiling of the covered space, said flexible panel further comprising at least two distinct zones, including at least one display zone intended to accommodate a display medium and at least one perforated zone fulfilling a dual function as an air passage and as a visibility window; - a plurality of linear elements for suspending the flexible panel distributed in said longitudinal direction and each comprising a first end suitable for being fixed to said ceiling , and a second end connected to said upper edge of said flexible panel , so as to be able to keep said flexible panel longitudinally suspended between the two parking spaces to be demarcated; - a heavy tube extending in the longitudinal direction and connected to said lower edge of said flexible panel so as to tension said flexible panel under the effect of gravity. - a flexible panel extending in said longitudinal direction corresponding to the direction for parking vehicles on both sides of the device, and comprising an upper edge and a lower edge oriented toward the ceiling and the ground surface , respectively, when said device is fixed to the ceiling of the covered space, said flexible panel further comprising at least two distinct zones, including at least one display zone intended to accommodate a display medium and at least one perforated zone fulfilling a dual function as an air passage and as a visibility window; - a plurality of linear elements for suspending the flexible panel distributed in said longitudinal direction and each comprising a first end suitable for being fixed to said ceiling , and a second end connected to said upper edge of said flexible panel , so as to be able to keep said flexible panel longitudinally suspended between the two parking spaces to be demarcated; - a heavy tube extending in the longitudinal direction and connected to said lower edge of said flexible panel so as to tension said flexible panel under the effect of gravity.
An elongate body comprising at least one multifilament fiber that comprises an ultra-high molecular weight polyolefin fiber formed from a plurality of ultra-high molecular weight polyolefin filaments, said ultra-high molecular weight polyolefin filaments having a filament intrinsic viscosity (IV f ) of from 15 dl/g to 45 dl/g when measured in decalin at 135°C, wherein said multifilament ultra-high molecular weight polyolefin fiber has a linear density greater than 889 dtex (denier greater than 800), characterized in that , each of the filaments of said multifilament ultra-high molecular weight polyolefin fiber has a linear density of at least 2.2 dtex (denier of at least 2.0), and the product of the linear density per filament in dtex of said filaments multiplied by the IV f of said filaments is from 83.3 to 122.2 (expressing the linear density of the filaments in denier the product is 75.0 to 110.0).
A method for wireless communications at a user equipment, UE, comprising: identifying a set of time-frequency resources available for remote interference reference signals; transmitting an indication of the set of time-frequency resources to a base station; receiving an indication of scheduling of a data transmission from the base station, wherein the scheduling comprises rate-matching the data transmission around the set of time-frequency resources available for remote interference reference signals; and communicating the data transmission with the base station via resources that are non-overlapping with the set of time-frequency resources. identifying a set of time-frequency resources available for remote interference reference signals; transmitting an indication of the set of time-frequency resources to a base station; receiving an indication of scheduling of a data transmission from the base station, wherein the scheduling comprises rate-matching the data transmission around the set of time-frequency resources available for remote interference reference signals; and communicating the data transmission with the base station via resources that are non-overlapping with the set of time-frequency resources.
A device for freeze moulding a ceramic sample in a magnetic field, comprising - a means for cooling, - a sample receiving device connected to the means for cooling and - a rotatably arranged permanent magnet, characterized in that - the permanent magnet is in the form of at least one annularly arranged Halbach magnet array, and - the Halbach magnet array is arranged in a plane (x-y) so as to be rotatable about the sample receiving device. - a means for cooling, - a sample receiving device connected to the means for cooling and - a rotatably arranged permanent magnet, characterized in that - the permanent magnet is in the form of at least one annularly arranged Halbach magnet array, and - the Halbach magnet array is arranged in a plane (x-y) so as to be rotatable about the sample receiving device.
A package for a liquid food product, said package comprising a container ; and a hollow body for transporting said liquid food product from said container, wherein said hollow body comprises a first part fixedly attached to a first section of said container and a second part releasably attached to a second section of said container; such that when said second part is released from said second section said second part is pivotable around one axis of rotation in an intersection point between said first part and said second part providing for that said second part is restricted to move in a pre-determined plane; wherein the first and second sections of the container are adjacent walls of the container, the hollow body is formed from a first piece and a second piece forming together a drinking device wherein a portion of a periphery of the first piece is attached to a portion of a periphery of the second piece so as to form a flow channel between a first end at the first part to be put in fluid communication with the interior of the container and a second end at the second part for the fluid to exit, characterised in that the first piece comprises a flat bottom to provide a contact area fixedly attached along the first part to the external surface of the first section of the container and releasably attached along the second part to the external surface of the second section of the container, the second piece has a transverse cross-section in a shape adapted to form the flow channel such that the second part is restricted to be pivotable relative to the first part around the intersection point in a pre-determined plane.