mhurhangee/patent-ind-claim-en huggingface dataset:
An engineered T cell receptor (TCR) comprising at least one of the following amino acid residues: L96 of the α chain; R9 of the β chain; Y10 of the β chain; T24 of the α chain; T20 of the α chain; M50 of the α chain; T5 of the α chain; Q8 of the α chain; S86 of the α chain; F39 of the α chain; D55 of the α chain; R43 of the β chain; A66 of the α chain; L21 of the β chain; L103 of the β chain; T3 of the α chain; P9 of the α chain; A16 of the α chain; T18 of the α chain; L21 of the α chain; S22 of the α chain; D26 of the α chain; F40 of the α chain; S47 of the α chain; R48 of the α chain; Q49 of the α chain; I51 of the α chain; L52 of the α chain; V53 of the α chain; T67 of the α chain; E68 of the α chain; N74 of the α chain; F76 of the α chain; N79 of the α chain; Q81 of the α chain; A83 of the α chain; K90 of the α chain; S92 of the α chain; D93 of the α chain; and M101 of the α chain; wherein the at least one amino acid residue is not present in the corresponding germline TCR amino acid sequence and wherein said TCR has a higher level of cell surface expression when expressed in a cell relative to an equivalent TCR comprising the amino acid sequence encoded by the germline sequence. L96 of the α chain; R9 of the β chain; Y10 of the β chain; T24 of the α chain; T20 of the α chain; M50 of the α chain; T5 of the α chain; Q8 of the α chain; S86 of the α chain; F39 of the α chain; D55 of the α chain; R43 of the β chain; A66 of the α chain; L21 of the β chain; L103 of the β chain; T3 of the α chain; P9 of the α chain; A16 of the α chain; T18 of the α chain; L21 of the α chain; S22 of the α chain; D26 of the α chain; F40 of the α chain; S47 of the α chain; R48 of the α chain; Q49 of the α chain; I51 of the α chain; L52 of the α chain; V53 of the α chain; T67 of the α chain; E68 of the α chain; N74 of the α chain; F76 of the α chain; N79 of the α chain; Q81 of the α chain; A83 of the α chain; K90 of the α chain; S92 of the α chain; D93 of the α chain; and M101 of the α chain;
A method for inhibiting or promoting the activity of proteins or peptides or for stabilizing or destabilizing proteins or peptides comprising the step of contacting a compound of Formula I with a first protein and a second protein under conditions suitable for cross-linking the first protein to the second protein, thereby cross-linking the first protein to the second protein, wherein the first protein comprises a first cysteine residue; the second protein comprises a second cysteine residue; the compound of Formula I is wherein Y is S, S=O, or S(=O) 2 ; n is 0, 1, 2, 3, or 4; and R is independently selected from the group consisting of -H, -OH, -NH 2 , -NHR', -N(R') 2 , alkyl, -OMs, -OTs, -OTf, and -CO 2 H; or any two geminal R groups, taken together, form an imine; or any two vicinal R groups, taken together, form a ring; wherein any alkyl or imine may be substituted with a carbamide, a carboxylate, or a hydroxyl; and R' is alkyl or aryl. Y is S, S=O, or S(=O) 2 ; n is 0, 1, 2, 3, or 4; and R is independently selected from the group consisting of -H, -OH, -NH 2 , -NHR', -N(R') 2 , alkyl, -OMs, -OTs, -OTf, and -CO 2 H; or any two geminal R groups, taken together, form an imine; or any two vicinal R groups, taken together, form a ring; wherein any alkyl or imine may be substituted with a carbamide, a carboxylate, or a hydroxyl; and R' is alkyl or aryl.
A video encoder , the video encoder being configured to: select at least one reference picture and a plurality of blocks in the at least one reference picture , characterized in that the video encoder is configured to calculate, for each selected block , a projected location in a current picture based on a motion vector associated to the selected block in the reference picture , determine each selected block , of which the projected location spatially overlaps with a current block in the current picture , to be a reference block, and generate for at least one reference block a partitioning predictor for the current block based on partitioning information of the reference block associated to the at least one reference picture . select at least one reference picture and a plurality of blocks in the at least one reference picture , characterized in that the video encoder is configured to calculate, for each selected block , a projected location in a current picture based on a motion vector associated to the selected block in the reference picture , determine each selected block , of which the projected location spatially overlaps with a current block in the current picture , to be a reference block, and generate for at least one reference block a partitioning predictor for the current block based on partitioning information of the reference block associated to the at least one reference picture .
A retractable ballpoint pen comprising a retraction mechanism to allow a ballpoint pen tip formed by metal to be retracted from a front end opening of a barrel formed by a synthetic resin by mounting the ballpoint pen tip at a front end of an ink storage cylinder directly or via a tip holder , by housing a ballpoint pen refill, directly storing thermochromic ink in the ink storage cylinder , by biasing by a first coil spring to a rear end of the barrel , and by operating an operating portion of an operating body ; and - a friction body , at a rear end of the barrel , used for friction of handwriting in the thermochromic ink, enabling thermochromism of the handwriting in the thermochromic ink with frictional heat produced at that time, and having rubber-like elasticity, - the ballpoint pen tip comprising a ball , a tip end part deformed inside and rotatably holding the ball , and a second coil spring disposed behind the ball and pressing the ball against an inner wall at the front end of the tip, - an angle α at which the tip end part is deformed inside is from 90 degrees to 120 degrees, - an outer diameter K of the tip end part deformed inside is from 1.0 times to 1.2 times a diameter of the ball , characterized in that - a pressing force of the second coil spring is greater than a gross weight of the retractable ballpoint pen , - the gross weight of the retractable ballpoint pen is 5 g or more and 10 g or less, and - a center of gravity (G) of the retractable ballpoint pen is located in the vicinity of the center in the longitudinal direction of the retractable ballpoint pen or located backwardly away from the center, regardless of an appearance/retraction state of the ballpoint pen tip . - a friction body , at a rear end of the barrel , used for friction of handwriting in the thermochromic ink, enabling thermochromism of the handwriting in the thermochromic ink with frictional heat produced at that time, and having rubber-like elasticity, - the ballpoint pen tip comprising a ball , a tip end part deformed inside and rotatably holding the ball , and a second coil spring disposed behind the ball and pressing the ball against an inner wall at the front end of the tip, - an angle α at which the tip end part is deformed inside is from 90 degrees to 120 degrees, - an outer diameter K of the tip end part deformed inside is from 1.0 times to 1.2 times a diameter of the ball , characterized in that - a pressing force of the second coil spring is greater than a gross weight of the retractable ballpoint pen , - the gross weight of the retractable ballpoint pen is 5 g or more and 10 g or less, and - a center of gravity (G) of the retractable ballpoint pen is located in the vicinity of the center in the longitudinal direction of the retractable ballpoint pen or located backwardly away from the center, regardless of an appearance/retraction state of the ballpoint pen tip .
A display panel , comprising at least one pixel unit group , at least one sensing line (S), a plurality of gate lines (G), a plurality of first data lines (D1) and a plurality of second data lines (D2), wherein each pixel unit group comprises a plurality of pixel units arranged in two rows and a plurality of columns, and each pixel unit comprises a light-emitting element, the sensing line (S) is configured to sense a light-emitting current or a light-emitting voltage of the light-emitting element, characterized in that the plurality of pixel units in each pixel unit group are connected to a same one of the gate lines (G) to receive a same gate signal, one of two pixel units in each column of each pixel unit group is connected to one of the first data lines (D1) corresponding thereto, other one of the two pixel units in each column of each pixel unit group is connected to one of the second data lines (D2) corresponding thereto, and the plurality of pixel units in each pixel unit group are connected to a same sensing line (S). each pixel unit group comprises a plurality of pixel units arranged in two rows and a plurality of columns, and each pixel unit comprises a light-emitting element, the sensing line (S) is configured to sense a light-emitting current or a light-emitting voltage of the light-emitting element, characterized in that the plurality of pixel units in each pixel unit group are connected to a same one of the gate lines (G) to receive a same gate signal, one of two pixel units in each column of each pixel unit group is connected to one of the first data lines (D1) corresponding thereto, other one of the two pixel units in each column of each pixel unit group is connected to one of the second data lines (D2) corresponding thereto, and the plurality of pixel units in each pixel unit group are connected to a same sensing line (S).
A computer-implemented method for mitigating effects of denial of service conditions, comprising: under the control of one or more computer systems configured with executable instructions, identifying one or more remotely deployed network points of presence from a plurality of remotely deployed network points of presence (506;606) based at least in part on a geographic region identified as an origin of a denial of service attack on one or more network destinations (502;602); taking one or more actions that cause at least one remote network service provider to route at least a portion of network traffic addressed to the one or more network destinations through the identified one or more remotely deployed network points of presence, wherein the one or more network destinations (502;602) correspond to one or more servers that are geographically remote from the identified one or more remotely deployed network points of presence; at least during network conditions indicative of a denial of service attack on the one or more network destinations (502;602), causing one or more computing devices at the identified one or more remotely deployed network points of presence to filter network traffic addressed to the one or more network destinations (502;602) prior to dispatching the filtered network traffic toward the one or more network destinations (502;602), the filtered network traffic excluding network traffic addressed to the one or more network destinations (502;602) determined to be illegitimate. identifying one or more remotely deployed network points of presence from a plurality of remotely deployed network points of presence (506;606) based at least in part on a geographic region identified as an origin of a denial of service attack on one or more network destinations (502;602); taking one or more actions that cause at least one remote network service provider to route at least a portion of network traffic addressed to the one or more network destinations through the identified one or more remotely deployed network points of presence, wherein the one or more network destinations (502;602) correspond to one or more servers that are geographically remote from the identified one or more remotely deployed network points of presence; at least during network conditions indicative of a denial of service attack on the one or more network destinations (502;602), causing one or more computing devices at the identified one or more remotely deployed network points of presence to filter network traffic addressed to the one or more network destinations (502;602) prior to dispatching the filtered network traffic toward the one or more network destinations (502;602), the filtered network traffic excluding network traffic addressed to the one or more network destinations (502;602) determined to be illegitimate.
A vehicle transporter having a stacking apparatus for stacking a vehicle on the vehicle transporter , wherein the stacking apparatus has a wheel support for supporting the wheels of only one axle of a multi-track vehicle and wheels of another axle of the multi-track vehicle can be placed on a deck of the vehicle transporter , wherein the wheel support has a support region transversely relative to a width of the deck and wherein the stacking apparatus has a pivoting lifting device for lifting and lowering the wheel support relative to the deck by means of a pivotal movement, characterised in that the pivoting lifting device has a lift arm and a coupling arm which are pivotably mounted on the one hand to the deck and on the other hand to the wheel support at pivot points arranged in the form of a four-bar linkage, so that the wheel support performs a tilting movement differing from the pivotal movement of the pivoting lifting device relative to the deck of the vehicle transporter . the pivoting lifting device has a lift arm and a coupling arm which are pivotably mounted on the one hand to the deck and on the other hand to the wheel support at pivot points arranged in the form of a four-bar linkage, so that the wheel support performs a tilting movement differing from the pivotal movement of the pivoting lifting device relative to the deck of the vehicle transporter .
A blockage remediation skid that is adapted to be operatively coupled to an ROV , the skid comprising: a skid fluid inlet ; and a skid fluid outlet , the blockage remediation skid characterized in that the skid fluid outlet is adapted to be placed in fluid communication with a returns downline from a surface vessel , and in that the blockage remediation skid further comprises: a skid pressurized lift-gas inlet that is adapted to be placed in fluid communication with a pressurized lift-gas supply downline from the surface vessel such that pressurized lift-gas may be introduced into the returns downline via the skid fluid outlet ; and a process vessel that is adapted to receive a production fluid from a subsea flowline or an item of subsea equipment wherein production fluid introduced into the process vessel is adapted to be introduced into the returns downline via the skid fluid outlet . a skid fluid inlet ; and a skid fluid outlet , the blockage remediation skid characterized in that the skid fluid outlet is adapted to be placed in fluid communication with a returns downline from a surface vessel , and in that the blockage remediation skid further comprises: a skid pressurized lift-gas inlet that is adapted to be placed in fluid communication with a pressurized lift-gas supply downline from the surface vessel such that pressurized lift-gas may be introduced into the returns downline via the skid fluid outlet ; and a process vessel that is adapted to receive a production fluid from a subsea flowline or an item of subsea equipment wherein production fluid introduced into the process vessel is adapted to be introduced into the returns downline via the skid fluid outlet .
A sealing apparatus of an electronic device to be used in hazardous areas comprising a cover , the sealing apparatus comprising: a gasket having an outer circumference, an inner circumference, and at least a first side ; an end adapter for closing the cover ; and a support element for the gasket , characterized in that the gasket comprises: a first inclined surface with respect to a longitudinal direction of the cover and which matches with a corresponding inclined surface of the end adapter so that a force (F2) is induced towards the surface of the cover when the length of the cover increases for improving sealing between the gasket and the cover ; a second inclined surface with respect to the longitudinal direction of the cover and which matches with a correspondent inclined surface of the support element so that a force (F4) is induced towards the surface of the cover when the length of the cover decreases; the end adapter comprises a slit at the location of an end of the cover for providing a free space between the end adapter and the end of the cover ; wherein the first inclined surface of the gasket is adapted to butt against the inclined surface of the end adapter of the electronic device . a gasket having an outer circumference, an inner circumference, and at least a first side ; an end adapter for closing the cover ; and a support element for the gasket , characterized in that the gasket comprises: a first inclined surface with respect to a longitudinal direction of the cover and which matches with a corresponding inclined surface of the end adapter so that a force (F2) is induced towards the surface of the cover when the length of the cover increases for improving sealing between the gasket and the cover ; a second inclined surface with respect to the longitudinal direction of the cover and which matches with a correspondent inclined surface of the support element so that a force (F4) is induced towards the surface of the cover when the length of the cover decreases; a first inclined surface with respect to a longitudinal direction of the cover and which matches with a corresponding inclined surface of the end adapter so that a force (F2) is induced towards the surface of the cover when the length of the cover increases for improving sealing between the gasket and the cover ; a second inclined surface with respect to the longitudinal direction of the cover and which matches with a correspondent inclined surface of the support element so that a force (F4) is induced towards the surface of the cover when the length of the cover decreases; the end adapter comprises a slit at the location of an end of the cover for providing a free space between the end adapter and the end of the cover ; wherein the first inclined surface of the gasket is adapted to butt against the inclined surface of the end adapter of the electronic device .
Method to weld folded lateral fins of the gusset type of a pre-wrapping that is the precursor of a hermetic wrapping formed around an organized group of smoking articles , each of said lateral fins comprising at least two portions each having a respective thickness (Sa, Sb, Sc) and formed by overlapping a different number of said flaps so that the thickness of one portion is different from the thickness (Sa, Sb, Sc) of the other portion , said pre-wrapping advancing in a longitudinal direction of feed (P), keeping said lateral fins of said pre-wrapping folded, so that said pre-wrapping has in succession, in said direction of feed (P), portions to be welded having a different thickness (Sa, Sb, Sc), characterized in that the welding of the lateral fins is an ultrasound welding, obtained by means of pairs of welding rollers that rotate in coordination with the feed of said pre-wrapping and that are disposed on one side and the other of said pre-wrapping , wherein said ultrasound welding is performed continuously while said pre-wrapping continues to move in said direction of feed (P), wherein at least one of said welding rollers is selectively made to vibrate radially so as to exert, on said lateral fins , a variable pressure as a function at least of the different thickness (Sa, Sb, Sc) of the portions that are progressively fed in said direction of feed (P).
A method for providing explanations in route planning for an autonomous vehicle, comprising: determining a route based on at least two objectives received from a user, wherein a second objective of the at least two objectives is constrained to within a slack value of a first objective of the at least two objectives, wherein the slack value defines a deviation from the first objective to improve the second objective; characterised in that the method further comprises: receiving, from the user, a request for an explanation as to an action along the route, the action being moving the autonomous vehicle from a first lane segment to a second lane segment along the route; and providing the explanation to the user, wherein the explanation describes an extent of violating the slack value. receiving, from the user, a request for an explanation as to an action along the route, the action being moving the autonomous vehicle from a first lane segment to a second lane segment along the route; and providing the explanation to the user, wherein the explanation describes an extent of violating the slack value.
A trans-anal irrigation device, comprising: a fluid supply including an irrigation liquid reservoir and a base , the reservoir including an openable top cap 42, the reservoir being removably mounted on the base and including a shut-off valve which is closed when the reservoir is removed from the base , the base including a projection which fits into the shut-off valve when the reservoir is mounted on the base to open the shut-off valve ; an irrigation head (12, 112, 214-224, 312, 414, 512) for insertion into a user's rectum, the head (12, 112, 214-224, 312, 414, 512) having a retainer releasably engageable with the user so as to selectably maintain the irrigation head in an inserted position; a controller ; tubing connecting the irrigation head (12, 112, 214-224, 312, 414, 512) to the reservoir ; and a pump in the base for delivering irrigation liquid from the reservoir through the tubing to the irrigation head (12, 112, 214-224, 312, 414, 512). a fluid supply including an irrigation liquid reservoir and a base , the reservoir including an openable top cap 42, the reservoir being removably mounted on the base and including a shut-off valve which is closed when the reservoir is removed from the base , the base including a projection which fits into the shut-off valve when the reservoir is mounted on the base to open the shut-off valve ; an irrigation head (12, 112, 214-224, 312, 414, 512) for insertion into a user's rectum, the head (12, 112, 214-224, 312, 414, 512) having a retainer releasably engageable with the user so as to selectably maintain the irrigation head in an inserted position; a controller ; tubing connecting the irrigation head (12, 112, 214-224, 312, 414, 512) to the reservoir ; and a pump in the base for delivering irrigation liquid from the reservoir through the tubing to the irrigation head (12, 112, 214-224, 312, 414, 512).