An electroporation system comprising: a catheter comprising a plurality of electrodes; and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes, the waveform including: a first pulse having a first polarity, a first pulse amplitude , and a first pulse width ; and a second pulse having a second polarity, a second pulse amplitude , and a second pulse width , wherein the first and second pulses are separated by an interpulse delay , and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width , wherein the waveform further includes a pulse pair including a third pulse having the first polarity followed by a fourth pulse having the second polarity, wherein the third and fourth pulses are separated by an interpulse delay, and wherein at least one of i) the third pulse has a different pulse amplitude and/or pulse width than the first pulse and ii) the fourth pulse has a different pulse amplitude and/or pulse width than the second pulse, and wherein the pulse pair either precedes the first pulse or follows the second pulse . a catheter comprising a plurality of electrodes; and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes, the waveform including: a first pulse having a first polarity, a first pulse amplitude , and a first pulse width ; and a second pulse having a second polarity, a second pulse amplitude , and a second pulse width , wherein the first and second pulses are separated by an interpulse delay , and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width , wherein the waveform further includes a pulse pair including a third pulse having the first polarity followed by a fourth pulse having the second polarity, wherein the third and fourth pulses are separated by an interpulse delay, and wherein at least one of i) the third pulse has a different pulse amplitude and/or pulse width than the first pulse and ii) the fourth pulse has a different pulse amplitude and/or pulse width than the second pulse, and wherein the pulse pair either precedes the first pulse or follows the second pulse . a first pulse having a first polarity, a first pulse amplitude , and a first pulse width ; and a second pulse having a second polarity, a second pulse amplitude , and a second pulse width , wherein the first and second pulses are separated by an interpulse delay , and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width , wherein the waveform further includes a pulse pair including a third pulse having the first polarity followed by a fourth pulse having the second polarity, wherein the third and fourth pulses are separated by an interpulse delay, and wherein at least one of i) the third pulse has a different pulse amplitude and/or pulse width than the first pulse and ii) the fourth pulse has a different pulse amplitude and/or pulse width than the second pulse, and wherein the pulse pair either precedes the first pulse or follows the second pulse . <EOS>