A syringe comprising: a first chamber (10; 2201); a cartridge (2306; 2405; 2700; 2802) movable within the first chamber, wherein the cartridge comprises: a cartridge chamber (30; 2203; 2303; 2405; 2504; 2603) comprising a liquid disposed within the cartridge chamber and a fluid gap located in a reduced diameter passage of the cartridge chamber and adjacent to the liquid and retained adjacent to the liquid until displaced by a change in volume of the cartridge chamber, a valve located in the reduced diameter passage, the valve in fluid communication with the cartridge chamber and the first chamber and adjacent to the fluid gap where the fluid gap separates the liquid disposed within the cartridge chamber from the first chamber; the valve having an open configuration and a closed configuration, the valve allowing movement of a liquid out of the cartridge chamber while in an open configuration, a second end (60; 2003; 2103; 2206; 2306; 2406; 2501; 2605; 2903), movable within the cartridge chamber, and a locking mechanism (2200; 2501) having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration. a first chamber (10; 2201); a cartridge (2306; 2405; 2700; 2802) movable within the first chamber, wherein the cartridge comprises: a cartridge chamber (30; 2203; 2303; 2405; 2504; 2603) comprising a liquid disposed within the cartridge chamber and a fluid gap located in a reduced diameter passage of the cartridge chamber and adjacent to the liquid and retained adjacent to the liquid until displaced by a change in volume of the cartridge chamber, a valve located in the reduced diameter passage, the valve in fluid communication with the cartridge chamber and the first chamber and adjacent to the fluid gap where the fluid gap separates the liquid disposed within the cartridge chamber from the first chamber; the valve having an open configuration and a closed configuration, the valve allowing movement of a liquid out of the cartridge chamber while in an open configuration, a second end (60; 2003; 2103; 2206; 2306; 2406; 2501; 2605; 2903), movable within the cartridge chamber, and a locking mechanism (2200; 2501) having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration. a cartridge chamber (30; 2203; 2303; 2405; 2504; 2603) comprising a liquid disposed within the cartridge chamber and a fluid gap located in a reduced diameter passage of the cartridge chamber and adjacent to the liquid and retained adjacent to the liquid until displaced by a change in volume of the cartridge chamber, a valve located in the reduced diameter passage, the valve in fluid communication with the cartridge chamber and the first chamber and adjacent to the fluid gap where the fluid gap separates the liquid disposed within the cartridge chamber from the first chamber; the valve having an open configuration and a closed configuration, the valve allowing movement of a liquid out of the cartridge chamber while in an open configuration, a second end (60; 2003; 2103; 2206; 2306; 2406; 2501; 2605; 2903), movable within the cartridge chamber, and a locking mechanism (2200; 2501) having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration. <EOS>