A system for treating a subject diagnosed with a dermal and/or mucosal-associated condition, said system comprising: (a) a dispensing package that includes: (i.) a lower subassembly that has a tubular body portion that defines an elongated interior fluid storage chamber into which a take-up piston element is slidably disposed; and (ii.) an upper subassembly mounted upon the lower subassembly and including a dispensing head and an airless pumping mechanism , the dispensing head having an internal dispensing duct formed therein which terminates in a self-closing outlet , the dispensing head also including a finger-operated actuator which is operatively associated with the airless pumping mechanism ; and (b) an imiquimod cream formulation disposed at least partially within the fluid storage chamber defined in the tubular body portion of the lower subassembly of the dispensing package, and wherein operation of the finger-operated actuator causes the airless pumping mechanism to withdraw a portion of the imiquimod cream formulation from within the interior chamber and to dispense the imiquimod cream formulation into the internal dispensing duct formed in the dispensing head wherein the pressure of dispensed cream causes the self-closing outlet to open thereby discharging a predefined effective unit dose amount of imiquimod cream from the dispensing package; wherein the take-up piston element is arranged and configured, upon actuation, to take up an amount from the fluid storage chamber that is equivalent to said predefined effective unit dose amount. (a) a dispensing package that includes: (i.) a lower subassembly that has a tubular body portion that defines an elongated interior fluid storage chamber into which a take-up piston element is slidably disposed; and (ii.) an upper subassembly mounted upon the lower subassembly and including a dispensing head and an airless pumping mechanism , the dispensing head having an internal dispensing duct formed therein which terminates in a self-closing outlet , the dispensing head also including a finger-operated actuator which is operatively associated with the airless pumping mechanism ; and (i.) a lower subassembly that has a tubular body portion that defines an elongated interior fluid storage chamber into which a take-up piston element is slidably disposed; and (ii.) an upper subassembly mounted upon the lower subassembly and including a dispensing head and an airless pumping mechanism , the dispensing head having an internal dispensing duct formed therein which terminates in a self-closing outlet , the dispensing head also including a finger-operated actuator which is operatively associated with the airless pumping mechanism ; and (b) an imiquimod cream formulation disposed at least partially within the fluid storage chamber defined in the tubular body portion of the lower subassembly of the dispensing package, and wherein operation of the finger-operated actuator causes the airless pumping mechanism to withdraw a portion of the imiquimod cream formulation from within the interior chamber and to dispense the imiquimod cream formulation into the internal dispensing duct formed in the dispensing head wherein the pressure of dispensed cream causes the self-closing outlet to open thereby discharging a predefined effective unit dose amount of imiquimod cream from the dispensing package; <EOS>