mhurhangee/patent-ind-claim-en huggingface dataset:
A method for the purification of Liraglutide, comprising: a) Providing a liquid composition C comprising Liraglutide and at least one unwanted component; b) Subjecting the composition C to a first reversed phase high performance liquid chromatogragph (RP-HPLC) purification at a pH between 7.0 and 7.8, wherein a hydrocarbon bonded silica is used as a stationary phase, a mobile phase comprising an aqueous phosphate buffer AB1 and acetonitrile is used, and elution is effected by gradually increasing the acetonitrile concentration within the mobile phase while collecting Liraglutide containing fractions; and c) Subjecting the pooled Liraglutide containing fractions obtained in step b) to a second reversed phase HPLC purification at a pH below 3.0, wherein a hydrocarbon bonded silica is used as a stationary phase, a mobile phase comprising trifluoroacetic acid and acetonitrile is used, and elution is effected by gradually increasing the acetonitrile concentration within the mobile phase while collecting fractions containing purified Liraglutide. a) Providing a liquid composition C comprising Liraglutide and at least one unwanted component; b) Subjecting the composition C to a first reversed phase high performance liquid chromatogragph (RP-HPLC) purification at a pH between 7.0 and 7.8, wherein a hydrocarbon bonded silica is used as a stationary phase, a mobile phase comprising an aqueous phosphate buffer AB1 and acetonitrile is used, and elution is effected by gradually increasing the acetonitrile concentration within the mobile phase while collecting Liraglutide containing fractions; and c) Subjecting the pooled Liraglutide containing fractions obtained in step b) to a second reversed phase HPLC purification at a pH below 3.0, wherein a hydrocarbon bonded silica is used as a stationary phase, a mobile phase comprising trifluoroacetic acid and acetonitrile is used, and elution is effected by gradually increasing the acetonitrile concentration within the mobile phase while collecting fractions containing purified Liraglutide.
Personal care device, in particular hair removal device such as an electric shaver, comprising an elongated handle for manually moving the personal care device along a body surface, a working head attached to said handle for effecting a personal care treatment to said body surface, said working head being movably supported relative to said handle and/or including a working head element being movably supported relative to a working head basis to allow adaption of the working head and/or of the working head element to the body surface contour, wherein an adjustment device is provided for adjusting a movability characteristics of a suspension of said working head and/or of said working head element , characterized in that said adjustment device includes at least one actuator (35, 50, 51, 52, 53, 54, 80, 81, 82; 105, 106) configured to adjust at least one of the following characteristics: - moving resistance of the working head and/or of the working head element depending on moving speed of the working head and/or the working head element , each relative to the handle, - restoring force/torque urging the working head and/or the working head element towards a neutral position depending on moving speed of the working head and/or of the working head element , - the shape of a graph defining a restoring force/restoring torque over rotatory and/or linear displacement of the working head and/or the working head element from a linear graph to a curved graph and/or the ratio of linear portions to non-linear portions of said graph. - moving resistance of the working head and/or of the working head element depending on moving speed of the working head and/or the working head element , each relative to the handle, - restoring force/torque urging the working head and/or the working head element towards a neutral position depending on moving speed of the working head and/or of the working head element , - the shape of a graph defining a restoring force/restoring torque over rotatory and/or linear displacement of the working head and/or the working head element from a linear graph to a curved graph and/or the ratio of linear portions to non-linear portions of said graph.
A tyre for running on rough terrain comprising a tread portion , wherein the tread portion includes a crown region (Cr), middle regions (Mi), and shoulder regions (sh), the crown region (Cr) has a center portion thereof positioned on a tyre equator (c) and a development width of one third of a tread development width (TWe), the middle regions (Mi) are arranged on both outer sides in a tyre axial direction of the crown region (Cr) and each have a development width of one sixth of the tread development width (TWe), the shoulder regions (sh) are arranged on both outer sides in the tyre axial direction of the middle regions (Mi) and each have a development width of one sixth of the tread development width (TWe), the crown region (Cr) is provided with a plurality of crown blocks , each of the middle regions (Mi) is provided with a plurality of middle blocks , and each of the shoulder regions (sh) is provided with a plurality of shoulder blocks , characterized in that each of the middle blocks is connected with at least one of the crown blocks by a crown tie bar and connected with at least one of the shoulder blocks by a shoulder tie bar , and a land ratio (Ls) of the shoulder regions (sh) is 90% or more and 115% or less of a land ratio (Lc) of the crown region (Cr).
Filtration system for filtering lubricating oil, particularly oil for marine units such as marine engines, having a storage container for lubricating oil, having a main flow filter with a filter housing in a main flow branch for lubricating oil between the storage container and the marine unit, and having a bypass flow filter with a filter housing in a bypass flow branch for lubricating oil, which opens into the storage container , wherein the filter housing of the main flow filter and the filter housing of the bypass flow filter each have an inlet (21; 61), an outlet (22; 62) and an installation space (26; 66) for an exchangeable filter insert, said space being arranged in the flow between the inlet and the outlet, characterized in that the installation space of the main flow filter can be fitted either with a back-flushable automatic filter insert or a non-back-flushable simple filter insert , or is fitted either with a back-flushable automatic filter insert or a non-back-flushable simple filter insert , in that the filter housing of the main flow filter has a back-flush outlet for back-flush fluid of a back-flushing device and in that the inlet of the bypass flow filter is connected to the back-flush outlet .
An antibody or antibody fragment specific for a polypeptide comprising SEQ ID NO.: 1, or an orthologue thereof, wherein said antibody binds to an extracellular loop of MprF, and wherein said antibody or antibody fragment increases the susceptibility of a pathogen to a cationic antimicrobial peptide, wherein the loop consists of an amino acid sequence of ELSGINFKDTLVEFSKINR (SEQ ID NO.: 2), LGFKTLGVPEEKV (SEQ ID NO.: 5), DALYDGNHLT (SEQ ID NO.: 6) or DIYTIEMHTSVLR (SEQ ID NO.: 7), wherein said pathogen is a gram-positive bacterium and wherein said gram-positive bacterium is Staphylococcus aureus.
A method of packaging a drug in a cartridge according to claim 10,said cylindrical bore prefilled in a distal portion thereof with the drug, the method comprising: providing the plunger seal inserted into said bore in a first state, the plunger seal including a cavity ; moving said plunger seal distally in said bore while the plunger seal is in said first state from outside the bore to a sealing position in the bore between said drug and said proximal opening ; supplying the core shaped toe fill at least a portion of the cavity and switching said plunger seal to a parked state in said sealing position, wherein said core applies the radially outward force against the inner wall of said cavity in said parked state, thereby increasing friction resistance to longitudinal movement of the plunger seal against the inner wall of the reservoir of at least 30% with respect to said first state, and wherein a distortion in the shape of said sealing region between said first state and said parked state is less than 0.2 mm . providing the plunger seal inserted into said bore in a first state, the plunger seal including a cavity ; moving said plunger seal distally in said bore while the plunger seal is in said first state from outside the bore to a sealing position in the bore between said drug and said proximal opening ; supplying the core shaped toe fill at least a portion of the cavity and switching said plunger seal to a parked state in said sealing position, wherein said core applies the radially outward force against the inner wall of said cavity in said parked state, thereby increasing friction resistance to longitudinal movement of the plunger seal against the inner wall of the reservoir of at least 30% with respect to said first state, and wherein a distortion in the shape of said sealing region between said first state and said parked state is less than 0.2 mm .
An illumination device comprising: a plurality of laser light sources that emit laser lights of different radiant fluxes; a plurality of diffractive optical elements separately provided correspondingly to the respective laser light sources ; and a plurality of shaping optical systems (30, 31a-31c, 32a-32c) separately provided correspondingly to the respective laser light sources ; wherein each shaping optical system of the plurality of shaping optical systems is configured to expand laser light emitted from a corresponding laser light source of the plurality of laser light sources over a whole area of an incident surface of the corresponding diffractive optical element, and to guide the laser light to the corresponding diffractive optical element of the plurality of diffractive optical elements, wherein a planar dimension of one diffractive optical element of the plurality of diffractive optical elements , which corresponds to one laser light source of the plurality of laser light sources that emits a laser light having a minimum radiant flux, is smaller than a planar dimension of another diffractive optical element of the plurality of diffractive optical elements , which corresponds to another laser light source of the plurality of laser light sources that emits a laser light having a maximum radiant flux. a plurality of laser light sources that emit laser lights of different radiant fluxes; a plurality of diffractive optical elements separately provided correspondingly to the respective laser light sources ; and a plurality of shaping optical systems (30, 31a-31c, 32a-32c) separately provided correspondingly to the respective laser light sources ; wherein each shaping optical system of the plurality of shaping optical systems is configured to expand laser light emitted from a corresponding laser light source of the plurality of laser light sources over a whole area of an incident surface of the corresponding diffractive optical element, and to guide the laser light to the corresponding diffractive optical element of the plurality of diffractive optical elements, wherein a planar dimension of one diffractive optical element of the plurality of diffractive optical elements , which corresponds to one laser light source of the plurality of laser light sources that emits a laser light having a minimum radiant flux, is smaller than a planar dimension of another diffractive optical element of the plurality of diffractive optical elements , which corresponds to another laser light source of the plurality of laser light sources that emits a laser light having a maximum radiant flux.
Adaptive aircraft engine for the subsonic and supersonic operation of an aircraft, having a turbofan three-shaft engine having two bypass ducts , having a first inner bypass duct in a core engine of the aircraft engine , and a second outer bypass duct which at least in part surrounds the first bypass duct ; and having adapting means, in particular adjustable nozzles , for varying a cross section of the core engine that is passed through by a flow and has the first bypass duct , and for varying the cross section of the second bypass duct that is passed through by a flow, as a function of the flight speed, characterized by a mixing device for a flow from the combustion chamber and a flow from the inner bypass duct , wherein the mixing device in the flow direction is disposed ahead of a low-pressure turbine .
A process for reducing the amount of compound of formula (I) and compound of formula (II) in a mixture of compound (I), compound (II) and compound (III), or solvates or salts thereof, wherein R 1 and R 2 are independently hydrogen or CH 3 , the process comprising: hydrogenation of the mixture in a composition containing sulfuric acid (H 2 SO 4 ) at a temperature of 115 °C or more, wherein the concentration of sulfuric acid is 10.2 wt % or more. hydrogenation of the mixture in a composition containing sulfuric acid (H 2 SO 4 ) at a temperature of 115 °C or more, wherein the concentration of sulfuric acid is 10.2 wt % or more.
An apparatus for a gas turbine engine, comprising: a first platform extending axially along and circumferentially about an axis ; a second platform extending axially along and circumferentially about the axis ; a plurality of vanes arranged circumferentially about the axis , each of the plurality of vanes extending radially across a gas path between the first platform and the second platform , and the plurality of vanes comprising a first vane movably connected to the first platform ; and a plurality of beams arranged circumferentially about the axis , the plurality of beams fixedly connected to the first platform and the second platform , and the plurality of beams comprising a first beam extending radially through the first vane ; characterised in that the first beam is formed integral with the first platform and the second platform . a first platform extending axially along and circumferentially about an axis ; a second platform extending axially along and circumferentially about the axis ; a plurality of vanes arranged circumferentially about the axis , each of the plurality of vanes extending radially across a gas path between the first platform and the second platform , and the plurality of vanes comprising a first vane movably connected to the first platform ; and a plurality of beams arranged circumferentially about the axis , the plurality of beams fixedly connected to the first platform and the second platform , and the plurality of beams comprising a first beam extending radially through the first vane ; characterised in that the first beam is formed integral with the first platform and the second platform .
An automated method for calibrating in real time a diagnostic analyzer , which comprises the steps of: - receiving diagnostic results of patient samples calculated by the analyzer using pre-set parameters of the analyzer ; - calculating a centroid of the patient sample diagnostic results of the analyzer ; - comparing the centroid of the patient sample diagnostic results of the analyzer with a centroid of diagnostic results of a reference population of comparable analyzers to determine a bias in the centroid of the patient sample diagnostic results of the analyzer ; - comparing the bias in the centroid of the patient sample diagnostic results of the analyzer with predetermined acceptable limits; - if the bias of the centroid of the patient sample diagnostic results of the analyzer falls within the predetermined acceptable limits, then not applying an optimization factor to the patient sample diagnostic results calculated by the analyzer using the pre-set parameters of the analyzer ; - if the bias of the centroid of the patient sample diagnostic results of the analyzer falls outside the predetermined acceptable limits, then applying the optimization factor to the patient sample diagnostic results of the analyzer to obtain optimized patient sample diagnostic results; and - outputting the optimized or un-optimized patient sample diagnostic results by the analyzer . - receiving diagnostic results of patient samples calculated by the analyzer using pre-set parameters of the analyzer ; - calculating a centroid of the patient sample diagnostic results of the analyzer ; - comparing the centroid of the patient sample diagnostic results of the analyzer with a centroid of diagnostic results of a reference population of comparable analyzers to determine a bias in the centroid of the patient sample diagnostic results of the analyzer ; - comparing the bias in the centroid of the patient sample diagnostic results of the analyzer with predetermined acceptable limits; - if the bias of the centroid of the patient sample diagnostic results of the analyzer falls within the predetermined acceptable limits, then not applying an optimization factor to the patient sample diagnostic results calculated by the analyzer using the pre-set parameters of the analyzer ; - if the bias of the centroid of the patient sample diagnostic results of the analyzer falls outside the predetermined acceptable limits, then applying the optimization factor to the patient sample diagnostic results of the analyzer to obtain optimized patient sample diagnostic results; and - outputting the optimized or un-optimized patient sample diagnostic results by the analyzer .
An infrared testing device (100; 200; 300; 400; 500) comprising: a body (110; 210), a solid state infrared source (120; 220), housed with the body (110; 210); a controller (150; 250) operatively coupled to the infrared source (120; 220); and a user input (140; 240) operatively coupled to at least one of the controller (150; 250) and the infrared source (120; 220); characterised in that : the solid state infrared source (120; 220) comprises a MEMS infrared source that sweeps through a plurality of infrared wavelengths and is configured to switch on and off as necessary to achieve a flicker effect of a flame; and in that the infrared testing device (100; 200; 300; 400; 500) further comprises: a lens removably coupled to the body that is configured to protect and/or house the infrared source and is further configured to modify, filter, and/or adapt emissions from the infrared source . a body (110; 210), a solid state infrared source (120; 220), housed with the body (110; 210); a controller (150; 250) operatively coupled to the infrared source (120; 220); and a user input (140; 240) operatively coupled to at least one of the controller (150; 250) and the infrared source (120; 220); a solid state infrared source (120; 220), housed with the body (110; 210); a controller (150; 250) operatively coupled to the infrared source (120; 220); and a user input (140; 240) operatively coupled to at least one of the controller (150; 250) and the infrared source (120; 220); characterised in that : the solid state infrared source (120; 220) comprises a MEMS infrared source that sweeps through a plurality of infrared wavelengths and is configured to switch on and off as necessary to achieve a flicker effect of a flame; and in that the infrared testing device (100; 200; 300; 400; 500) further comprises: a lens removably coupled to the body that is configured to protect and/or house the infrared source and is further configured to modify, filter, and/or adapt emissions from the infrared source .
A row of artificial eyelashes to be fixed to the edge of an eyelid, having (i) a base part intended to be fixed to the edge of the eyelid, and (ii) false eyelashes , the base part having a first chain-stitch knitted warp thread , the false eyelashes passing through the chain stitches without being tied thereto, wherein the base part has a second chain-stitch knitted warp thread , the false eyelashes passing through the chain stitches without being tied thereto, the row of artificial eyelashes being characterized in that the first and second warp threads are interwoven. the base part having a first chain-stitch knitted warp thread , the false eyelashes passing through the chain stitches without being tied thereto, wherein the base part has a second chain-stitch knitted warp thread , the false eyelashes passing through the chain stitches without being tied thereto, the row of artificial eyelashes being characterized in that the first and second warp threads are interwoven.
A device for ground improvement of soil prior to loading of a structure, comprising: (a) a top plate having a first surface configured for having a driving device attached thereto to provide impact thereon; (b) a plurality of vertically extending tines rigidly attached to a second surface of the top plate opposite the first surface of the top plate, and horizontally spaced from each other at upper lateral edges thereof, for being driven into a ground surface in response to the impact provided by the driving device; and (c) the tines being shaped, spaced, and oriented relative to each other in a manner to achieve displacement of ground material downward and radially outward, wherein the tines are tapered at an angle in the range of 0.5° to 5°, and wherein the tines have a length to width ratio of 9 to 14.5, 15 to 30 or 30 to 60. (a) a top plate having a first surface configured for having a driving device attached thereto to provide impact thereon; (b) a plurality of vertically extending tines rigidly attached to a second surface of the top plate opposite the first surface of the top plate, and horizontally spaced from each other at upper lateral edges thereof, for being driven into a ground surface in response to the impact provided by the driving device; and (c) the tines being shaped, spaced, and oriented relative to each other in a manner to achieve displacement of ground material downward and radially outward, wherein the tines are tapered at an angle in the range of 0.5° to 5°, and wherein the tines have a length to width ratio of 9 to 14.5, 15 to 30 or 30 to 60.
A method of checking a tufting tongue of a tufting tool of a machine for making brushes, wherein the following steps are provided: - performing, between two tufting steps, at least one blank tufting step, in which the tufting tongue emerges from the tufting tool freely; - detecting, during the blank tufting step, the portion of the tufting tongue emerging from the tufting tool ; - determining, by a comparison with target data, whether the tufting tongue meets the criteria required for proper operation of the brush making machine . - performing, between two tufting steps, at least one blank tufting step, in which the tufting tongue emerges from the tufting tool freely; - detecting, during the blank tufting step, the portion of the tufting tongue emerging from the tufting tool ; - determining, by a comparison with target data, whether the tufting tongue meets the criteria required for proper operation of the brush making machine .