Compounds of the formula I in which R 1 denotes C(CH 3 ) 2 SO 2 A', CH 2 OSO 2 A', C(CH 3 ) 2 OH, -[C(R 3 ) 2 ] n Het 1 , or 1-methylsulfonyl-cycloprop-1-yl, R 2 denotes Het 2 , NR 3 (CH 2 ) n Het 2 , OHet 2 , Ar 1 , CONHHet 3 , COHet 3 or CONHA, R 3 denotes H or A', Het 1 denotes imidazolyl, pyrazolyl, triazolyl or pyridyl, each of which is unsubstituted or monosubstituted by COOH, COOA', CH 2 OH, CH 2 OA' or A, Het 2 denotes 1 H -pyrrolo[2,3-b]pyridinyl, 1 H -pyrrolo[2,3-c]pyridinyl, indolyl, benzimidazolyl, imidazolyl, 1,2,3,4-tetrahydroisoquinolyl, pyridyl, triazolyl, pyrazolyl, quinolyl, isoquinolyl, quinazolinyl or 1,3-dihydro-2lamda6-2,2-dioxo-1-benzothiazolyl, each of which is unsubstituted or mono- or disubstituted by Hal, A', -[C(R 3 ) 2 ] n OR 3 , CONH 2 , SO 2 phenyl, benzyl, CN, -[C(R 3 ) 2 ] n NH 2 , -[C(R 3 ) 2 ] n NHA, oxetanyl-NH- and/or NHCOA, Het 3 denotes triazolyl, pyridazinyl, pyrimidinyl, pyrazolyl or pyrrolidinyl each of which is unsubstituted or monosubstituted by -[C(R 3 ) 2 ] n OR 3 , -[C(R 3 ) 2 ] n NH 2 or =O, Ar 1 denotes phenyl monosubstituted by -[C(R 3 ) 2 ] n OR 3 , imidazolyl, -[C(R 3 ) 2 ] n NH 2 , pyrazolyl, aziridinyl or oxetanyl, each of which may be unsubstituted or monosubstituted by -[C(R 3 ) 2 ] n OR 3 or -[C(R 3 ) 2 ] n NH 2 , A denotes unbranched or branched alkyl having 1-6 C-atoms, in which 1-7 H atoms may be replaced by OH, F, Cl and/or Br and/or in which one or two non-adjacent CH 2 groups may be replaced by O and/or NH groups, A' denotes unbranched or branched alkyl having 1-4 C-atoms, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2 or 3, and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. R 1 denotes C(CH 3 ) 2 SO 2 A', CH 2 OSO 2 A', C(CH 3 ) 2 OH, -[C(R 3 ) 2 ] n Het 1 , or 1-methylsulfonyl-cycloprop-1-yl, R 2 denotes Het 2 , NR 3 (CH 2 ) n Het 2 , OHet 2 , Ar 1 , CONHHet 3 , COHet 3 or CONHA, R 3 denotes H or A', Het 1 denotes imidazolyl, pyrazolyl, triazolyl or pyridyl, each of which is unsubstituted or monosubstituted by COOH, COOA', CH 2 OH, CH 2 OA' or A, Het 2 denotes 1 H -pyrrolo[2,3-b]pyridinyl, 1 H -pyrrolo[2,3-c]pyridinyl, indolyl, benzimidazolyl, imidazolyl, 1,2,3,4-tetrahydroisoquinolyl, pyridyl, triazolyl, pyrazolyl, quinolyl, isoquinolyl, quinazolinyl or 1,3-dihydro-2lamda6-2,2-dioxo-1-benzothiazolyl, each of which is unsubstituted or mono- or disubstituted by Hal, A', -[C(R 3 ) 2 ] n OR 3 , CONH 2 , SO 2 phenyl, benzyl, CN, -[C(R 3 ) 2 ] n NH 2 , -[C(R 3 ) 2 ] n NHA, oxetanyl-NH- and/or NHCOA, Het 3 denotes triazolyl, pyridazinyl, pyrimidinyl, pyrazolyl or pyrrolidinyl each of which is unsubstituted or monosubstituted by -[C(R 3 ) 2 ] n OR 3 , -[C(R 3 ) 2 ] n NH 2 or =O, Ar 1 denotes phenyl monosubstituted by -[C(R 3 ) 2 ] n OR 3 , imidazolyl, -[C(R 3 ) 2 ] n NH 2 , pyrazolyl, aziridinyl or oxetanyl, each of which may be unsubstituted or monosubstituted by -[C(R 3 ) 2 ] n OR 3 or -[C(R 3 ) 2 ] n NH 2 , A denotes unbranched or branched alkyl having 1-6 C-atoms, in which 1-7 H atoms may be replaced by OH, F, Cl and/or Br and/or in which one or two non-adjacent CH 2 groups may be replaced by O and/or NH groups, A' denotes unbranched or branched alkyl having 1-4 C-atoms, Hal denotes F, Cl, Br or I, n denotes 0, 1, 2 or 3, <EOS>