mhurhangee/patent-ind-claim-en huggingface dataset:
A covalent conjugate comprising i) a bispecific antibody, which has a first binding specificity, which specifically binds to a haptenylated payload, and a second binding specificity, which specifically binds to a blood brain barrier receptor, and ii) a haptenylated payload, wherein the haptenylated payload is specifically bound by the first binding specificity, wherein the covalent conjugate has a disulfide bond between the haptenylated payload and a cysteine residue at an amino acid residue in the CDR2 in the first binding specificity that specifically binds to the haptenylated payload, wherein the CDR2 is the heavy chain CDR2, the haptenylated payload is selected from the group consisting of biotinylated payloads, theophyllinylated payloads, digoxigenylated payloads, and fluoresceinylated payloads and the cysteine is at position 52b or 53 according to the Kabat numbering, or wherein the CDR2 is the light chain CDR2, when the haptenylated payload is a helicarylated payload, and the cysteine is at position 55 or 51 according to the Kabat numbering, and wherein the blood brain barrier receptor is transferrin receptor (TfR) or low density lipoprotein receptor-related protein 8 (LRP8). i) a bispecific antibody, which has a first binding specificity, which specifically binds to a haptenylated payload, and a second binding specificity, which specifically binds to a blood brain barrier receptor, and ii) a haptenylated payload, wherein the haptenylated payload is specifically bound by the first binding specificity, wherein the covalent conjugate has a disulfide bond between the haptenylated payload and a cysteine residue at an amino acid residue in the CDR2 in the first binding specificity that specifically binds to the haptenylated payload, wherein the CDR2 is the heavy chain CDR2, the haptenylated payload is selected from the group consisting of biotinylated payloads, theophyllinylated payloads, digoxigenylated payloads, and fluoresceinylated payloads and the cysteine is at position 52b or 53 according to the Kabat numbering, or wherein the CDR2 is the light chain CDR2, when the haptenylated payload is a helicarylated payload, and the cysteine is at position 55 or 51 according to the Kabat numbering, and wherein the blood brain barrier receptor is transferrin receptor (TfR) or low density lipoprotein receptor-related protein 8 (LRP8).
A quick blade repair and replacement enabled apparatus integrating medical waste crushing and steam treatment, the apparatus being an integrally assembled vertical structure capable of being disassembled, wherein the apparatus sequentially comprises three chamber bodies, connected into a whole by using flanges and bolts, of a feeding and stirring chamber , a crushing chamber , and a sterilization and discharging chamber from top to bottom, the three chamber bodies internally form a communicating sealable space, and are vertically placed on a support frame as a whole, and a power mechanism is provided outside a chamber body of the crushing chamber; a top end and a bottom end of the crushing chamber are respectively opening flange structures, a left side and a right side of the chamber body (2-1) of the crushing chamber are respectively provided with repair gates (2-3), and a rotary blade assembly and a stationary blade assembly are provided in the crushing chamber; two ends of a rotary blade shaft (2-2) of the rotary blade assembly are respectively fixed on the repair gates by using bearings, bearing supports are connected to the repair gates (2-3) as a whole, one end of the rotary blade shaft extends out of the chamber body of the crushing chamber, and is connected to the power mechanism (2-5), and the power mechanism uses a sprocket or a gear transmission structure; rotary blades (2-6) of the rotary blade assembly are mounted on the rotary blade shaft, blade claws of adjacent rotary blades are arranged by staggering at an angle, and rotary blades on the different rotary blade shafts are alternately arranged; stationary blades (2-7) of the stationary blade assembly are fixed on an inner wall of the chamber body (2-1) of the crushing chamber by using pressing plates (2-8), and the pressing plates are secured from outside of the chamber body of the crushing chamber by using bolts; and the rotary blades (2-6) and the stationary blades (2-7) are alternately arranged.
A support for a reel, comprising a reel and a pair of removable flanges adapted to be attached on both sides of said reel , said support being characterized in that each of said flanges comprises: a rotary control button for locking said flange on said reel , said button having a circular perimeter and having a diametric gripping rib operable between a locked position and an unlocked position of said flange and a locking tab extending radially from the circumference of said button ; two feet each having a removable side end part ; a transport handle , fixed or movable between a storage position and a use position. a rotary control button for locking said flange on said reel , said button having a circular perimeter and having a diametric gripping rib operable between a locked position and an unlocked position of said flange and a locking tab extending radially from the circumference of said button ; two feet each having a removable side end part ; a transport handle , fixed or movable between a storage position and a use position.
A lens unit comprising: a plurality of lenses ; and a cylindrical holder configured to hold the plurality of lenses , wherein the plurality of lenses include a cemented lens obtained by bonding a second lens through an adhesive layer to a first lens , the first lens is a plastic lens including a concave lens surface facing a side of the second lens , and a first flange part surrounding the concave lens surface at an outer peripheral side, the second lens is a plastic lens including a convex lens surface bonded by the adhesive layer on the concave lens surface with facing a side of the first lens , and a second flange part surrounding the convex lens surface at an outer peripheral side, when T0 denotes a center thickness in an optical axis (L) direction of the second lens and C denotes a thickness in an optical axis (L) direction of the second flange part , the thicknesses T0 and C satisfy a relationship of: 2.0 ≤ T 0 / C ≤ 3.2 , and when n0 denotes a refractive index of the adhesive layer , n1 denotes a refractive index of the first lens , and n2 denotes a refractive index of the second lens , the refractive indexes n0, n1, and n2 satisfy the following relationship of: n 1 − n 0 > n 2 − n 0 , wherein in the second lens , when T1 denotes a dimension in an optical axis (L) direction from the apex of the convex lens surface to a surface at the side of the first lens of the second flange part , the dimension T1 and the thickness C satisfy a relationship of: T 1 / C ≤ 1.5 .
A single-handed, single-operator controlled, implant-free device for lowering intraocular pressure comprising: a) a cannula comprising a sharpened distal tip , wherein the sharpened distal tip comprises an opening with a smooth edge , b) a flexible conduit comprising a polymer slidably disposed within the cannula, and advanceable distally from the opening, wherein the conduit comprises an atraumatic distal tip and is sized to advance into Schlemm's canal for disruption of the trabecular meshwork upon removal of the cannula from an eye while leaving the conduit in the canal, thereby tearing through the meshwork; and c) a handle coupled to the cannula, wherein the handle is configured to advance and retract the conduit with a single hand. a) a cannula comprising a sharpened distal tip , wherein the sharpened distal tip comprises an opening with a smooth edge , b) a flexible conduit comprising a polymer slidably disposed within the cannula, and advanceable distally from the opening, wherein the conduit comprises an atraumatic distal tip and is sized to advance into Schlemm's canal for disruption of the trabecular meshwork upon removal of the cannula from an eye while leaving the conduit in the canal, thereby tearing through the meshwork; and c) a handle coupled to the cannula, wherein the handle is configured to advance and retract the conduit with a single hand.
A catalyst composition for producing mixed alcohols comprising a catalytic metal combination on a catalyst support, a first promoter and a second promoter, wherein the catalytic metal combination consists of iridium in an amount of from 10 to 650 micromoles per gram, vanadium in an amount of from 20 to 800 micromoles per gram, and molybdenum in an amount of from 30 to 850 micromoles per gram, each micromole per gram based on the mass of the catalyst support prior to the addition of the catalytic metal combination, the first promoter, and the second promoter, wherein the first promoter is selected from zirconium, rhenium, palladium, hafnium, manganese, tungsten and combinations thereof, and the second promoter is selected from potassium, lithium, sodium, rubidium, cesium and combinations thereof, and wherein the composition does not contain rhodium.
A method for preparing lixisenatide, comprising: step 1: synthesizing Fmoc-Lys-resin by solid-phase synthesis ; step 2: coupling an amino acid and a dipeptide to the Fmoc-Lys-resin according to the peptide sequence of lixisenatide to obtain lixisenatide peptide resin; wherein the dipeptide is selected from the group consisting of -Gly-Thr, -Phe-Thr, -Thr-Ser, -Leu-Ser, -Ser-Ser and -Pro-Ser; and step 3: cleaving the lixisenatide peptide resin to obtain lixisenatide, wherein coupling -Gly-Thr is performed by using Fmoc-Gly-Thr(PSI ME, ME Pro)-OH; coupling -Phe-Thr is performed by using Fmoc-Phe-Thr(PSI ME, ME Pro)-OH; coupling -Thr-Ser is performed by using Fmoc-Thr(tBu)-Ser(PSI ME, ME Pro)-OH; coupling -Leu-Ser is performed by using Fmoc-Leu-Ser(PSI ME, ME Pro)-OH; coupling -Ser-Ser is performed by using Fmoc-Ser(tBu)-Ser(PSI ME, ME Pro)-OH; and coupling -Pro-Ser is performed by using Fmoc-Pro-Ser(PSI ME, ME Pro)-OH. step 1: synthesizing Fmoc-Lys-resin by solid-phase synthesis ; step 2: coupling an amino acid and a dipeptide to the Fmoc-Lys-resin according to the peptide sequence of lixisenatide to obtain lixisenatide peptide resin; wherein the dipeptide is selected from the group consisting of -Gly-Thr, -Phe-Thr, -Thr-Ser, -Leu-Ser, -Ser-Ser and -Pro-Ser; and step 3: cleaving the lixisenatide peptide resin to obtain lixisenatide, coupling -Gly-Thr is performed by using Fmoc-Gly-Thr(PSI ME, ME Pro)-OH; coupling -Phe-Thr is performed by using Fmoc-Phe-Thr(PSI ME, ME Pro)-OH; coupling -Thr-Ser is performed by using Fmoc-Thr(tBu)-Ser(PSI ME, ME Pro)-OH; coupling -Leu-Ser is performed by using Fmoc-Leu-Ser(PSI ME, ME Pro)-OH; coupling -Ser-Ser is performed by using Fmoc-Ser(tBu)-Ser(PSI ME, ME Pro)-OH; and coupling -Pro-Ser is performed by using Fmoc-Pro-Ser(PSI ME, ME Pro)-OH.
A surgical lead comprising: a flexible panel ; a set of electrode arrays embedded in the flexible panel; a set of leads integrally formed with the flexible panel; a set of lumens ; at least one lumen of the set of lumens resident in at least one lead of the set of leads; a set of conductors in the at least one lead of the set of leads; a set of contacts , attached to the at least one lead of the set of leads; at least one conductor of the set of conductors, connected between a contact of the set of contacts and an electrode array of the set of electrode arrays; a set of window portals , in the flexible panel, adjacent to and distal from the set of electrode arrays; a set of optical fibers ; a set of side firing sections ; at least one optical fiber of the set of optical fibers having at least one side firing section of the set of side firing sections; at least one optical fiber of the set of optical fibers resident in the at least one lumen of the set of lumens; the at least one side firing section positioned adjacent a window portal of the set of window portals; a set of ferrules ; and, at least one ferrule, of the set of ferrules, positioned on the at least one optical fiber of the set of optical fibers. a flexible panel ; a set of electrode arrays embedded in the flexible panel; a set of leads integrally formed with the flexible panel; a set of lumens ; at least one lumen of the set of lumens resident in at least one lead of the set of leads; a set of conductors in the at least one lead of the set of leads; a set of contacts , attached to the at least one lead of the set of leads; at least one conductor of the set of conductors, connected between a contact of the set of contacts and an electrode array of the set of electrode arrays; a set of window portals , in the flexible panel, adjacent to and distal from the set of electrode arrays; a set of optical fibers ; a set of side firing sections ; at least one optical fiber of the set of optical fibers having at least one side firing section of the set of side firing sections; at least one optical fiber of the set of optical fibers resident in the at least one lumen of the set of lumens; the at least one side firing section positioned adjacent a window portal of the set of window portals; a set of ferrules ; and, at least one ferrule, of the set of ferrules, positioned on the at least one optical fiber of the set of optical fibers.
The non-therapeutic use of a urolithin for improving cognitive function, improving or maintaining mental performance, improving or maintaining mood, or managing stress in generally healthy individuals, wherein the urolithin is urolithin A.
Device for regulating the entry of light into a room, comprising a switchable layer S having a thickness of greater than 12 μm comprising a liquid-crystalline medium which comprises at least one dichroic compound and one or more chiral compounds, where the dielectric anisotropy Δε of the liquid-crystalline medium is less than -3, where the following applies to the thickness d of layer S and the optical anisotropy Δn of the liquid-crystalline medium of layer S: d < 1 μ ⁢ m / Δn and where the molecules of the liquid-crystalline medium of layer S are in a twisted nematic state in the switching state of the device without an applied electrical voltage or in the switching state of the device with an applied electrical voltage, and where the device has precisely one switchable layer.
A shaving system comprising: a handle having a distal end and a proximal end, and a shaving assembly comprising an interface element configured to removably interface with the handle and a blade unit pivotably mounted on the interface element, characterized in that the handle includes a protrusion at its distal end having a pair of walls extending perpendicular to the longitudinal axis of the handle, and the interface element of the shaving assembly includes a cavity, wherein the cavity is an asymmetrical cavity configured to receive the protrusion in a predetermined manner such that only one orientation is possible, and wherein complementary keyed structures are provided, comprising channels on both of the walls of the pair of walls of the protrusion and complementary ribs on surfaces of the cavity which oppose the walls. a handle having a distal end and a proximal end, and a shaving assembly comprising an interface element configured to removably interface with the handle and a blade unit pivotably mounted on the interface element, characterized in that the handle includes a protrusion at its distal end having a pair of walls extending perpendicular to the longitudinal axis of the handle, and the interface element of the shaving assembly includes a cavity, wherein the cavity is an asymmetrical cavity configured to receive the protrusion in a predetermined manner such that only one orientation is possible, and wherein complementary keyed structures are provided, comprising channels on both of the walls of the pair of walls of the protrusion and complementary ribs on surfaces of the cavity which oppose the walls.
A pressure fixing device applied to a shoe , wherein the shoe comprises a shoe body and a bottom part , the shoe body comprises plural eyelets and the bottom part is connected to the shoe body to define a wear space collaboratively, the pressure fixing device comprising: an inflatable shoe tongue connected with the shoe body , wherein the inflatable shoe tongue is an inflatable and expandable structure with an air, an opening is collaboratively defined by the inflatable shoe tongue and the shoe body , and the opening is in communication with the wear space ; a first air pump in communication with the inflatable shoe tongue ; and a control module electrically connected to the first air pump ; wherein the control module drives the air flowing out of the inflatable shoe tongue according to a second enabling signal so that the inflatable shoe tongue shrinks in a first direction toward the wear space to attach to an user's instep, and the control module drives the first air pump to pump the air flowing into the inflatable shoe tongue according to a first enabling signal, so that the inflatable shoe tongue expands and bulges in a second direction away from the wear space to enlarge the opening . an inflatable shoe tongue connected with the shoe body , wherein the inflatable shoe tongue is an inflatable and expandable structure with an air, an opening is collaboratively defined by the inflatable shoe tongue and the shoe body , and the opening is in communication with the wear space ; a first air pump in communication with the inflatable shoe tongue ; and a control module electrically connected to the first air pump ; wherein the control module drives the air flowing out of the inflatable shoe tongue according to a second enabling signal so that the inflatable shoe tongue shrinks in a first direction toward the wear space to attach to an user's instep, and the control module drives the first air pump to pump the air flowing into the inflatable shoe tongue according to a first enabling signal, so that the inflatable shoe tongue expands and bulges in a second direction away from the wear space to enlarge the opening .
Longitudinal adjuster for a vehicle seat , comprising: - a rail arrangement (SA) with two rail pairs (P1, P2) of seat rails , the respective rail pair (P1, P2) having a fixed seat rail and a seat rail which is movable relative to the fixed seat rail , - a motor unit , - a gear unit (G) which couples the motor unit and the movable seat row of at least one of the rail pairs (P1) to one another, and - a holder for receiving a gear housing of the gear unit (G), the holder being arranged with the gear unit (G) in a cavity (BR) which is formed by way of the one rail pair (P1) and being fastened to its movable seat rail , and being of open configuration at one end (5.7) and being of closed configuration at the opposite end, the holder comprising at least two holding limbs (5.2) which are spaced apart from one another in the longitudinal direction and extend vertically, the gear housing being arranged between the holding limbs (5.2), characterized in that the holder has, at the open end (5.7), at least one reinforcing element (5.6) which connects free ends of the holding limbs (5.2) which form the open end (5.7) of the holder . - a rail arrangement (SA) with two rail pairs (P1, P2) of seat rails , the respective rail pair (P1, P2) having a fixed seat rail and a seat rail which is movable relative to the fixed seat rail , - a motor unit , - a gear unit (G) which couples the motor unit and the movable seat row of at least one of the rail pairs (P1) to one another, and - a holder for receiving a gear housing of the gear unit (G), the holder being arranged with the gear unit (G) in a cavity (BR) which is formed by way of the one rail pair (P1) and being fastened to its movable seat rail , and being of open configuration at one end (5.7) and being of closed configuration at the opposite end, the holder comprising at least two holding limbs (5.2) which are spaced apart from one another in the longitudinal direction and extend vertically, the gear housing being arranged between the holding limbs (5.2), characterized in that the holder has, at the open end (5.7), at least one reinforcing element (5.6) which connects free ends of the holding limbs (5.2) which form the open end (5.7) of the holder .
A method to coat a substrate, comprising: mixing at least one crosslinker, at least one high molecular weight polymer having an average molecular weight above 30,000, an initiator and a solvent to produce a pre-coating mixture; applying the pre-coating mixture to the substrate, wherein the pre-coating mixture can be applied uniformly on the substrate or can vary on the substrate; initiating a reaction to crosslink the at least one crosslinker in the pre-coating mixture to produce a gradient crosslinked coating on the substrate, wherein the crosslinked coating entraps the at least one high molecular weight polymer, and the gradient coating includes a variable concentration of the crosslinker between a substrate surface of the gradient coating and an outer surface of the gradient coating such that the substrate surface of the gradient coating comprises a first coating polar characteristic and the outer surface of the gradient coating comprises a second coating polar characteristic, wherein the substrate surface of the gradient coating is adjacent to the exterior surface of the substrate, wherein the polar characteristic of the substrate results in the substrate being hydrophobic or hydrophilic; and wherein the gradient is modulated by the choice of the solvent, the drying time, temperature, and its polarity; and wherein said high molecular weight polymer is a polyvinylpyrrolidone. mixing at least one crosslinker, at least one high molecular weight polymer having an average molecular weight above 30,000, an initiator and a solvent to produce a pre-coating mixture; applying the pre-coating mixture to the substrate, wherein the pre-coating mixture can be applied uniformly on the substrate or can vary on the substrate; initiating a reaction to crosslink the at least one crosslinker in the pre-coating mixture to produce a gradient crosslinked coating on the substrate, wherein the crosslinked coating entraps the at least one high molecular weight polymer, and the gradient coating includes a variable concentration of the crosslinker between a substrate surface of the gradient coating and an outer surface of the gradient coating such that the substrate surface of the gradient coating comprises a first coating polar characteristic and the outer surface of the gradient coating comprises a second coating polar characteristic, wherein the substrate surface of the gradient coating is adjacent to the exterior surface of the substrate, wherein the polar characteristic of the substrate results in the substrate being hydrophobic or hydrophilic; and wherein the gradient is modulated by the choice of the solvent, the drying time, temperature, and its polarity; and wherein said high molecular weight polymer is a polyvinylpyrrolidone.