System for automatically detecting a clinically relevant leak and/or inadequate closure following a medical procedure, in an at least partially hollow organ or mutually fluidly connected hollow organs, residing in the interior volume of a body cavity , wherein said system comprises at least: injection means configured to inject in a controlled manner a specific test gas (TG), or a gas mixture containing at least one test gas (TG), into said organ(s) , said injection means comprising or being associated with first gas pressure measuring means , detection means configured to analyze the gas mixture (GM) and in particular to measure the concentration of test gas (TG), in the interior volume of the body cavity or at least in the space adjacent to said organ(s) , and possibly the gas pressure (GMP) within said volume or space, computational means configured to manage the injection and detection means (3 and 5), to store and retrieve data from an integrated local or remote database and to analyze data and to evaluate the likelihood of the presence of a leak or of the existence of a faulty closure, and its degree of severity, by comparing stored and realtime data, whereby the computational means are linked to sensor means arranged in said organ(s) and in said cavity or in fluidic circulation or gas feeding lines leading to said organ(s) and the adjacent space or interior volume of the body cavity and allowing to determine the pressure difference (ΔP) between the interior of the hollow organ(s) and the adjacent space or interior volume of the body cavity , said computational means being configured to control or master said pressure difference (ΔP) by driving accordingly associated injection and/or suction means , incorporating said test gas (TG) injection means . injection means configured to inject in a controlled manner a specific test gas (TG), or a gas mixture containing at least one test gas (TG), into said organ(s) , said injection means comprising or being associated with first gas pressure measuring means , detection means configured to analyze the gas mixture (GM) and in particular to measure the concentration of test gas (TG), in the interior volume of the body cavity or at least in the space adjacent to said organ(s) , and possibly the gas pressure (GMP) within said volume or space, computational means configured to manage the injection and detection means (3 and 5), to store and retrieve data from an integrated local or remote database and to analyze data and to evaluate the likelihood of the presence of a leak or of the existence of a faulty closure, and its degree of severity, by comparing stored and realtime data, whereby the computational means are linked to sensor means arranged in said organ(s) and in said cavity or in fluidic circulation or gas feeding lines leading to said organ(s) and the adjacent space or interior volume of the body cavity and allowing to determine the pressure difference (ΔP) between the interior of the hollow organ(s) and the adjacent space or interior volume of the body cavity , said computational means being configured to control or master said pressure difference (ΔP) by driving accordingly associated injection and/or suction means , incorporating said test gas (TG) injection means . <EOS>