mhurhangee/patent-ind-claim-en huggingface dataset:
A method of generating an antibody that exhibits pH-dependent binding to an antigen of interest comprising immunizing a genetically modified non-human mammal with an antigen of interest, wherein the genetically modified non-human mammal comprises in its germline an immunoglobulin light chain locus that comprises (i) a single rearranged human immunoglobulin light chain variable region gene sequence comprising human V L and J L segment sequences and (ii) an immunoglobulin light chain constant region gene sequence in operable linkage to the single rearranged human immunoglobulin light chain variable region gene sequence, wherein the single rearranged human immunoglobulin light chain variable region gene sequence comprises at least one genetically engineered insertion or substitution of a histidine codon that is not encoded by corresponding human germline V L and J L gene sequences, wherein the single rearranged human immunoglobulin light chain variable region gene sequence encodes an immunoglobulin chain comprising a light chain variable domain, wherein the histidine codon is in the nucleotide sequence encoding a complementarity determining region (CDR) of the light chain variable domain, wherein the light chain variable domain comprises at least one histidine residue at an amino acid position encoded by the at least one inserted or substituted histidine codon, and wherein the immunoglobulin light chain encoded by the immunoglobulin light chain locus is capable of pairing with a plurality of immunoglobulin heavy chains selected by the non-human mammal, wherein each of the plurality of immunoglobulin heavy chains specifically bind different epitopes when paired with the immunoglobulin light chain, and wherein the method further comprises selecting an antibody that binds to the antigen of interest with a desired affinity at a neutral pH while displaying reduced binding to the antigen of interest at an acidic pH.
A method performed by a contact center management system , the method comprising: identifying initiation of a chat communication session with a user device operated by a user; connecting an automated chat resource to the chat communication session; routing the chat communication session to a first agent device operated by a first agent; monitoring the communication session to provide automated chat communication messages during the chat communication session; detecting a disconnection of the user device from the chat communication session; maintaining the connection to the chat communication session by the automated chat resource during a timeout period after the disconnection of the user device is detected thereby enabling the user device to return or disconnect repeatedly until an affirmative end to the chat communication session is detected; detecting the user device reconnecting to the chat communication session; and routing the chat communication session to a contact center resource. identifying initiation of a chat communication session with a user device operated by a user; connecting an automated chat resource to the chat communication session; routing the chat communication session to a first agent device operated by a first agent; monitoring the communication session to provide automated chat communication messages during the chat communication session; detecting a disconnection of the user device from the chat communication session; maintaining the connection to the chat communication session by the automated chat resource during a timeout period after the disconnection of the user device is detected thereby enabling the user device to return or disconnect repeatedly until an affirmative end to the chat communication session is detected; detecting the user device reconnecting to the chat communication session; and routing the chat communication session to a contact center resource.
Method for the automatic control of a manufacturing system of discrete manufacturing and semiprocess manufacturing, comprising the following method steps: - Acquisition of sensor data during operation of the manufacturing system - Classification of the acquired sensor data by pre-processing the acquired sensor data and, based on this, calculating a processing window with TARGET process points, each of which represents a set of process values, the application of which can produce without errors, for error-free operation of the manufacturing system , - Determining an adjustment data set as a command variable for the manufacturing system by creating test plans with probable command variables and calculating associated process values in a simulation model, which are compared with the process values of the respective previously calculated TARGET process points of the processing window and by improving the command variables step by step until the calculated associated process points are in the processing window and close to the respective calculated TARGET process points, characterized in that a material flow in the manufacturing system is controlled, wherein produced quantities are detected at machines, work stations and/or during a transport and wherein the material flow is controlled by the determined adjustment data set, comprising run times at work stations and an allocation of resources, and that the stepwise improvement of the command variables is performed according to the rule "steepest ascent". - Acquisition of sensor data during operation of the manufacturing system - Classification of the acquired sensor data by pre-processing the acquired sensor data and, based on this, calculating a processing window with TARGET process points, each of which represents a set of process values, the application of which can produce without errors, for error-free operation of the manufacturing system , - Determining an adjustment data set as a command variable for the manufacturing system by creating test plans with probable command variables and calculating associated process values in a simulation model, which are compared with the process values of the respective previously calculated TARGET process points of the processing window and by improving the command variables step by step until the calculated associated process points are in the processing window and close to the respective calculated TARGET process points,
A motor controller configured to drive a permanent magnet synchronous motor - PMSM -, the motor controller comprising: a current controller configured to generate control signals for driving the PMSM, wherein the current controller is configured to measure voltage information of the PMSM and current information of the PMSM; a flux estimator configured to receive the voltage information and the current information and calculate a rotor magnetic flux linkage based on the voltage information and the current information; and a demagnetization detector configured to continuously monitor for a demagnetization of a rotor permanent magnet of the PMSM during operation of the PMSM based on the flux linkage magnitude, wherein the demagnetization detector is configured to compare the flux linkage magnitude to a predefined demagnetization level and detect the demagnetization on a first condition that the flux linkage magnitude is equal to or less than the predefined demagnetization level, characterized by an extraction circuit configured to receive the rotor magnetic flux linkage and extract a flux linkage magnitude of the rotor magnetic flux linkage from the received rotor magnetic flux linkage, and in that, based on the first condition being satisfied, the demagnetization detector is configured to monitor a duration that the flux linkage magnitude remains equal to or less than the predefined demagnetization level, compare the monitored duration to a timing threshold, and detect the demagnetization on a second condition that the monitored duration is equal to or exceeds the timing threshold. a current controller configured to generate control signals for driving the PMSM, wherein the current controller is configured to measure voltage information of the PMSM and current information of the PMSM; a flux estimator configured to receive the voltage information and the current information and calculate a rotor magnetic flux linkage based on the voltage information and the current information; and a demagnetization detector configured to continuously monitor for a demagnetization of a rotor permanent magnet of the PMSM during operation of the PMSM based on the flux linkage magnitude, wherein the demagnetization detector is configured to compare the flux linkage magnitude to a predefined demagnetization level and detect the demagnetization on a first condition that the flux linkage magnitude is equal to or less than the predefined demagnetization level, characterized by an extraction circuit configured to receive the rotor magnetic flux linkage and extract a flux linkage magnitude of the rotor magnetic flux linkage from the received rotor magnetic flux linkage, and in that, based on the first condition being satisfied, the demagnetization detector is configured to monitor a duration that the flux linkage magnitude remains equal to or less than the predefined demagnetization level, compare the monitored duration to a timing threshold, and detect the demagnetization on a second condition that the monitored duration is equal to or exceeds the timing threshold.
Luminaire , comprising a luminaire base , a luminaire head as well as a luminaire stand extending between the luminaire base and the luminaire head , wherein the luminaire head comprises first illuminants , which are arranged in a common plane (E), and which are adapted to extract a first, indirect fraction of light , and wherein the luminaire head moreover comprises a glare suppression arrangement , characterized in that the glare suppression arrangement is arranged in parallel to the plane (E), and comprises a light-directing foil as well as shielding elements , wherein the shielding elements are arranged such that a beam spread (γ) of the indirect fraction of light after passage through the glare suppression arrangement is limited to 30° with respect to a vertical (V) to the plane (E), and wherein the glare suppression arrangement in the direction of the vertical (V) has a maximum height (H) of 2.0 cm.
A compound, or a pharmaceutically acceptable salt thereof, having the formula: wherein R 1 is a substituted or unsubstituted C 5 cycloalkyl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted 5 to 6 membered heteroaryl; R 2 is hydrogen, halogen, -CF 3 , -CCl 3 , -CN, -OH, -NH 2 , -COOH, -CONH 2 , - NO 2 , -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCH 3 , -OCF 3 , -OCHF 2 , - C(O)CH 3 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3 is independently halogen, -CF 3 , -CCl 3 , -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCH 3 , -OCF 3 , -OCHF 2 , - C(O)CH 3 , unsubstituted alkyl, or unsubstituted heteroalkyl; and n is independently an integer from 0 to 5. R 1 is a substituted or unsubstituted C 5 cycloalkyl, substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted 5 to 6 membered heteroaryl; R 2 is hydrogen, halogen, -CF 3 , -CCl 3 , -CN, -OH, -NH 2 , -COOH, -CONH 2 , - NO 2 , -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCH 3 , -OCF 3 , -OCHF 2 , - C(O)CH 3 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R 3 is independently halogen, -CF 3 , -CCl 3 , -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 2 Cl, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCH 3 , -OCF 3 , -OCHF 2 , - C(O)CH 3 , unsubstituted alkyl, or unsubstituted heteroalkyl; and n is independently an integer from 0 to 5.
A light projector module for projecting an image, comprising: a support ; a light source supported by the support and configured to emit in a beam path (P) a light beam carrying said image ; a micro-electro-mechanical-system, MEMS, mirror supported by the support and configured to deflect the emitted light beam received over the beam path (P) as a deflected light beam ; a waveguide supported by the support and having two parallel sides , the first side having an in-coupling area for receiving the deflected light beam and the second side having an out-coupling area for projecting the deflected light beam with enlarged cross section; and a static mirror in the beam path (P) from the light source to the MEMS mirror to fold the beam path (P) about an angle of folding (δ); wherein the static mirror lies beside the first side of the waveguide , characterised in that the support is a housing enclosing at least the light source , the MEMS mirror , the waveguide , and the static mirror , wherein the housing has a window exposing the out-coupling area of the waveguide , the housing is attached to or integrated into a temple of a spectacle frame , and the beam path from the light source to the static mirror runs substantially parallel to the longitudinal axis (A) of the temple . a support ; a light source supported by the support and configured to emit in a beam path (P) a light beam carrying said image ; a micro-electro-mechanical-system, MEMS, mirror supported by the support and configured to deflect the emitted light beam received over the beam path (P) as a deflected light beam ; a waveguide supported by the support and having two parallel sides , the first side having an in-coupling area for receiving the deflected light beam and the second side having an out-coupling area for projecting the deflected light beam with enlarged cross section; and a static mirror in the beam path (P) from the light source to the MEMS mirror to fold the beam path (P) about an angle of folding (δ); wherein the static mirror lies beside the first side of the waveguide , characterised in that the support is a housing enclosing at least the light source , the MEMS mirror , the waveguide , and the static mirror , wherein the housing has a window exposing the out-coupling area of the waveguide , the housing is attached to or integrated into a temple of a spectacle frame , and the beam path from the light source to the static mirror runs substantially parallel to the longitudinal axis (A) of the temple .
A urinary catheter assembly, comprising: a sealed package defining a cavity; a hydration medium; a urinary catheter located within the cavity, the urinary catheter having an exterior surface; a hydrophilic material on the exterior surface of the urinary catheter; and a removable moisture control layer covering at least a portion of the hydrophilic material; wherein the moisture control layer comprises a wax, one or more aliphatic alcohols, or a combination of wax and one or more aliphatic alcohols. a sealed package defining a cavity; a hydration medium; a urinary catheter located within the cavity, the urinary catheter having an exterior surface; a hydrophilic material on the exterior surface of the urinary catheter; and a removable moisture control layer covering at least a portion of the hydrophilic material; wherein the moisture control layer comprises a wax, one or more aliphatic alcohols, or a combination of wax and one or more aliphatic alcohols.
A milk suction and collection device, which is integrally manufactured and molded by silicone, the milk suction and collection device comprising: a main body , which is hollow inside to define a milk storage chamber; a breast protecting film , provided on a side in a thickness direction of the main body and configured to be fitted with an outer periphery of a breast, wherein the breast protecting film is provided with a milk collecting port communicating with the milk storage chamber; characterized in that : the main body is further provided with a milk pouring port operative to be selectively blocked; and wherein a connecting band is provided on a side of the milk pouring port , and a sealing plug is arranged on and protrudes from the connecting band and is operative to be inserted into the milk pouring port to seal the milk pouring port . a main body , which is hollow inside to define a milk storage chamber; a breast protecting film , provided on a side in a thickness direction of the main body and configured to be fitted with an outer periphery of a breast, wherein the breast protecting film is provided with a milk collecting port communicating with the milk storage chamber; characterized in that : the main body is further provided with a milk pouring port operative to be selectively blocked; and wherein a connecting band is provided on a side of the milk pouring port , and a sealing plug is arranged on and protrudes from the connecting band and is operative to be inserted into the milk pouring port to seal the milk pouring port . the main body is further provided with a milk pouring port operative to be selectively blocked; and wherein a connecting band is provided on a side of the milk pouring port , and a sealing plug is arranged on and protrudes from the connecting band and is operative to be inserted into the milk pouring port to seal the milk pouring port .
A door opening/closing device controlling opening/closing of a door based on a user operation performed by being in contact with an operation handle served as a handle at a time of opening/closing the door , the door opening/closing device comprising: a detection unit provided in the operation handle and configured to detect a contact state of a user with the operation handle ; a door driving unit configured to open or close the door ; and a control unit configured to determine that a first operation involving a direction is a user operation, wherein the control unit is configured to control the door driving unit and open or close the door based on the user operation that is determined, characterized in that the control unit is configured to determine that the first operation is the user operation under the condition that the first operation and a second operation for determining the validity of the first operation are detected by the detection unit, wherein the second operation is a second user operation performed by being in contact with the operation handle and the control unit is configured to determine that the first operation is the user operation under a further condition that an interval between the first operation and the second operation is equal to or longer than a predetermined determination time. a detection unit provided in the operation handle and configured to detect a contact state of a user with the operation handle ; a door driving unit configured to open or close the door ; and a control unit configured to determine that a first operation involving a direction is a user operation, wherein the control unit is configured to control the door driving unit and open or close the door based on the user operation that is determined, characterized in that the control unit is configured to determine that the first operation is the user operation under the condition that the first operation and a second operation for determining the validity of the first operation are detected by the detection unit, wherein the second operation is a second user operation performed by being in contact with the operation handle and the control unit is configured to determine that the first operation is the user operation under a further condition that an interval between the first operation and the second operation is equal to or longer than a predetermined determination time.
A method for forming an assembly fixture, comprising: heating a composite material into a viscous form, wherein the composite material comprises a thermoplastic and a plurality of reinforcement fibers , wherein the plurality of reinforcement fibers is randomly arranged within the thermoplastic ; extruding a plurality of strands of the composite material, wherein extruding the plurality of strands causes the plurality of reinforcement fibers within each strand to align; and arranging the plurality of strands of the composite material to form an assembly fixture , wherein the assembly fixture comprises an anisotropic thermal expansion property, and wherein the anisotropic thermal expansion property is based on an orientation of the plurality of reinforcement fibers within the assembly fixture . heating a composite material into a viscous form, wherein the composite material comprises a thermoplastic and a plurality of reinforcement fibers , wherein the plurality of reinforcement fibers is randomly arranged within the thermoplastic ; extruding a plurality of strands of the composite material, wherein extruding the plurality of strands causes the plurality of reinforcement fibers within each strand to align; and arranging the plurality of strands of the composite material to form an assembly fixture , wherein the assembly fixture comprises an anisotropic thermal expansion property, and wherein the anisotropic thermal expansion property is based on an orientation of the plurality of reinforcement fibers within the assembly fixture .
A display device (2-19), designed as an electronic price display tag, comprising + a storage stage for storing a product data record (PD1-PD3), which was received during communication with a base station via a first wireless interface of the display device (2-19), the storage stage having an availability data record (VD), which is linked with the product data record (PD) and with the aid of which the availability of the product data record (PD) can be controlled, and + a second wireless interface for RFID or NFC communication with a self-checkout device , + the display device (2-19) is designed for processing a self-checkout query received from a self-checkout device for the purpose of transmitting the product data record (PD) via the second wireless interface , characterized in that the availability of the product data record (PD) relates to a temporal availability, in which the said product data record (PD) is available, and the display device (2-19) is designed to check the availability data record (VD) as to whether the product data record (PD) is available in a timelimited manner, and to process the query within the temporal availability using the said product data record (PD) or outside the temporal availability using a different product data record or not at all or in a different manner. + a storage stage for storing a product data record (PD1-PD3), which was received during communication with a base station via a first wireless interface of the display device (2-19), the storage stage having an availability data record (VD), which is linked with the product data record (PD) and with the aid of which the availability of the product data record (PD) can be controlled, and + a second wireless interface for RFID or NFC communication with a self-checkout device , + the display device (2-19) is designed for processing a self-checkout query received from a self-checkout device for the purpose of transmitting the product data record (PD) via the second wireless interface , characterized in that the availability of the product data record (PD) relates to a temporal availability, in which the said product data record (PD) is available, and the display device (2-19) is designed to check the availability data record (VD) as to whether the product data record (PD) is available in a timelimited manner, and to process the query within the temporal availability using the said product data record (PD) or outside the temporal availability using a different product data record or not at all or in a different manner.