mhurhangee/patent-ind-claim-en huggingface dataset:
A method for culturing primitive-like macrophages from human pluripotent stem cells, wherein the human pluripotent stem cells are human embryonic stem cells or human induced pluripotent stem cells, wherein the method comprises: a) plating said human pluripotent stem cells at a density of less than 1 small colony/cm 2 on Matrigel-coated 6-well plates for at least 24 hours in a media comprising 80% DMEM/F12, 20% knockout serum replacement, L-glutamine, non-essential amino acids, beta-mercaptoethanol and 6 ng/ml FGF-2; b) contacting and incubating said human pluripotent stem cells from step (a) with a serum-free culture media comprising 50ng/ml VEGF, 5 mg/ml BMP4 and a GSK3 inhibitor under hypoxic conditions to induce differentiation of said human pluripotent stem cells into cells of the mesoderm lineage; c) contacting and incubating said cells of the mesoderm lineage with a culture media comprising 50ng/ml SCF, 10 ng/nl FGF-2, 20 ng/ml IL-3, 10 ng/ml IL-6, 10ng/ml VEGF and 30 ng/ml DKK1 under hypoxic conditions for until day 8 to differentiate the cells of the mesoderm lineage into cells of the hematopoietic cell lineage, and subsequently incubating the cells under normoxic conditions; d) maturing said cells of the hematopoietic cell lineage by contacting said cells with a culture media comprising 50 ng/ml SCF, 10 ng/ml FGF-2, 20 ng/ml IL-3 and 10 ng/ml IL-6 under normoxic conditions; e) contacting and incubating said mature cells of the hematopoietic cell lineage with a culture media comprising 50 ng/ml M-CSF under normoxic conditions to drive the differentiation of said hematopoietic cells into primitive-like macrophages. wherein the primitive-like macrophages express CD163, CD11b, HLA-DR, IBA-1, CX3CR1 and CD14. a) plating said human pluripotent stem cells at a density of less than 1 small colony/cm 2 on Matrigel-coated 6-well plates for at least 24 hours in a media comprising 80% DMEM/F12, 20% knockout serum replacement, L-glutamine, non-essential amino acids, beta-mercaptoethanol and 6 ng/ml FGF-2; b) contacting and incubating said human pluripotent stem cells from step (a) with a serum-free culture media comprising 50ng/ml VEGF, 5 mg/ml BMP4 and a GSK3 inhibitor under hypoxic conditions to induce differentiation of said human pluripotent stem cells into cells of the mesoderm lineage; c) contacting and incubating said cells of the mesoderm lineage with a culture media comprising 50ng/ml SCF, 10 ng/nl FGF-2, 20 ng/ml IL-3, 10 ng/ml IL-6, 10ng/ml VEGF and 30 ng/ml DKK1 under hypoxic conditions for until day 8 to differentiate the cells of the mesoderm lineage into cells of the hematopoietic cell lineage, and subsequently incubating the cells under normoxic conditions; d) maturing said cells of the hematopoietic cell lineage by contacting said cells with a culture media comprising 50 ng/ml SCF, 10 ng/ml FGF-2, 20 ng/ml IL-3 and 10 ng/ml IL-6 under normoxic conditions; e) contacting and incubating said mature cells of the hematopoietic cell lineage with a culture media comprising 50 ng/ml M-CSF under normoxic conditions to drive the differentiation of said hematopoietic cells into primitive-like macrophages.
A rotor assembly for a gas turbine engine comprising: a rotor defining an outer periphery ; and a plurality of blades including a common material and geometric shape arranged on the outer periphery , wherein a first plurality of blades includes a first material property different than a second material property of a second plurality of blades, wherein the first material property comprises a first elastic modulus and the second material property comprises a second elastic modulus, different from the first elastic modulus, and wherein the rotor comprises an integrally bladed rotor with the first and the second plurality of blades welded to the rotor. a rotor defining an outer periphery ; and a plurality of blades including a common material and geometric shape arranged on the outer periphery , wherein a first plurality of blades includes a first material property different than a second material property of a second plurality of blades, wherein the first material property comprises a first elastic modulus and the second material property comprises a second elastic modulus, different from the first elastic modulus, and wherein the rotor comprises an integrally bladed rotor with the first and the second plurality of blades welded to the rotor.
An antibody against CCR8 having ADCC activity, for use in a method of treating a cancer, wherein the antibody against CCR8 is a CCR8-neutralizing antibody.
A liquid-crystal medium, comprising one or more compounds of formula I in which R 11 and R 12 identically or differently, denote H, an alkyl or alkoxy radical having 1 to 15 C atoms, in which one or more CH 2 groups in these radicals are optionally replaced, independently of one another, by -C≡C-, -CF 2 O-, -OCF 2 -, -CH=CH-, -O-, -CO-O- or -O-CO- in such a way that O atoms are not linked directly to one another, and in which one or more H atoms may be replaced by halogen, and one or more compounds selected from the group of compounds of the formulae II and III in which R 2 and R 3 independently of each other, denote alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy with 1 to 7 C-atoms, alkenyl, alkenyloxy, alkoxyalkyl or fluorinated alkenyl with 2 to 7 C-atoms, to are independently of each other L 21 , L 22 , L 31 and L 32 independently of each other, denote H or F, Y 2 , Y 3 identically or differently, denote H or CH 3 , X 2 and X 3 independently of each other, denote halogen, halogenated alkyl or alkoxy with 1 to 3 C-atoms or halogenated alkenyl or alkenyloxy with 2 or 3 C-atoms, Z 3 denotes -CH 2 CH 2 -, -CF 2 CF 2 -, -COO-, trans- -CH=CH-, trans -CF=CF-, -CH 2 O- or a single bond, and l, m, n and o are, independently of each other, 0 or 1. R 11 and R 12 identically or differently, denote H, an alkyl or alkoxy radical having 1 to 15 C atoms, in which one or more CH 2 groups in these radicals are optionally replaced, independently of one another, by -C≡C-, -CF 2 O-, -OCF 2 -, -CH=CH-, -O-, -CO-O- or -O-CO- in such a way that O atoms are not linked directly to one another, and in which one or more H atoms may be replaced by halogen, R 2 and R 3 independently of each other, denote alkyl, alkoxy, fluorinated alkyl or fluorinated alkoxy with 1 to 7 C-atoms, alkenyl, alkenyloxy, alkoxyalkyl or fluorinated alkenyl with 2 to 7 C-atoms, to are independently of each other L 21 , L 22 , L 31 and L 32 independently of each other, denote H or F, Y 2 , Y 3 identically or differently, denote H or CH 3 , X 2 and X 3 independently of each other, denote halogen, halogenated alkyl or alkoxy with 1 to 3 C-atoms or halogenated alkenyl or alkenyloxy with 2 or 3 C-atoms, Z 3 denotes -CH 2 CH 2 -, -CF 2 CF 2 -, -COO-, trans- -CH=CH-, trans -CF=CF-, -CH 2 O- or a single bond, and l, m, n and o are, independently of each other, 0 or 1.
A method for estimating range between a first device and a second device using at least one wireless communication channel defined between the first and second devices, the method comprising: obtaining a set of range measurements (r i ), wherein the range measurements (r i ) include measurements associated with multiple paths (path 1, path 2, path 3) taken by signals between the first and second devices; estimating a preliminary range profile using regression or speed data of at least one of the first device and the second device; discarding over-ranges caused by multiple signal paths (path 1, path 2, path 3) using a variable threshold; obtaining an estimated range , where the estimated range is a sum of the preliminary range profile and the variable threshold; iterating the steps of discarding the over-ranges and obtaining the estimated range, wherein the variable threshold is updated at the end of each iteration; stopping the iteration when a threshold number of range measurements from the set of range measurements (r i ) are left below a curve of the estimated range obtained from a previous iteration; and obtaining a final estimated range, the final estimated range being the estimated range in the last iteration. obtaining a set of range measurements (r i ), wherein the range measurements (r i ) include measurements associated with multiple paths (path 1, path 2, path 3) taken by signals between the first and second devices; estimating a preliminary range profile using regression or speed data of at least one of the first device and the second device; discarding over-ranges caused by multiple signal paths (path 1, path 2, path 3) using a variable threshold; obtaining an estimated range , where the estimated range is a sum of the preliminary range profile and the variable threshold; iterating the steps of discarding the over-ranges and obtaining the estimated range, wherein the variable threshold is updated at the end of each iteration; stopping the iteration when a threshold number of range measurements from the set of range measurements (r i ) are left below a curve of the estimated range obtained from a previous iteration; and obtaining a final estimated range, the final estimated range being the estimated range in the last iteration.
A nanoparticle-drug conjugate (NDC) comprising: (a) a silica nanoparticle; (b) polyethylene glycol (PEG) that is covalently bonded to the surface of the nanoparticle; (c) a targeting ligand comprising folic acid, wherein the targeting ligand is attached to the nanoparticle directly or indirectly through a spacer group; and (d) a linker-payload conjugate, wherein: (i) the payload is exatecan; (ii) the linker-payload conjugate is attached to the nanoparticle through a spacer group; (iii) the linker is a protease-cleavable linker; and (iv) the exatecan is released upon cleavage of the linker. (a) a silica nanoparticle; (b) polyethylene glycol (PEG) that is covalently bonded to the surface of the nanoparticle; (c) a targeting ligand comprising folic acid, wherein the targeting ligand is attached to the nanoparticle directly or indirectly through a spacer group; and (d) a linker-payload conjugate, wherein: (i) the payload is exatecan; (ii) the linker-payload conjugate is attached to the nanoparticle through a spacer group; (iii) the linker is a protease-cleavable linker; and (iv) the exatecan is released upon cleavage of the linker. (i) the payload is exatecan; (ii) the linker-payload conjugate is attached to the nanoparticle through a spacer group; (iii) the linker is a protease-cleavable linker; and (iv) the exatecan is released upon cleavage of the linker.
An anti-counterfeiting printed material comprising: a background part formed with C/M/Y/K lines each having an included angle preset according to each distribution of C/M/Y/K obtained by a first color separation, the first color separation being of an original image into C/M/Y/K; and a latent image part formed in a first region of the background part, and printed with the number of C/M/Y/K lines per inch different from the number of C/M/Y/K lines per inch of the background part according to each distribution of C/M/Y/K obtained by performing secondary color separation, into C/M/Y/K, of a second region spaced apart from the first region by a preset distance, the latent image being formed by: selecting a color whose sum of the distributions is greater than or equal to a preset value among the C/M/Y/K obtained by the secondary color separation in the second region; and forming the latent image by forming the color into the number of lines per inch different from the number of lines per inch of the background part. a background part formed with C/M/Y/K lines each having an included angle preset according to each distribution of C/M/Y/K obtained by a first color separation, the first color separation being of an original image into C/M/Y/K; and a latent image part formed in a first region of the background part, and printed with the number of C/M/Y/K lines per inch different from the number of C/M/Y/K lines per inch of the background part according to each distribution of C/M/Y/K obtained by performing secondary color separation, into C/M/Y/K, of a second region spaced apart from the first region by a preset distance, the latent image being formed by: selecting a color whose sum of the distributions is greater than or equal to a preset value among the C/M/Y/K obtained by the secondary color separation in the second region; and forming the latent image by forming the color into the number of lines per inch different from the number of lines per inch of the background part. selecting a color whose sum of the distributions is greater than or equal to a preset value among the C/M/Y/K obtained by the secondary color separation in the second region; and forming the latent image by forming the color into the number of lines per inch different from the number of lines per inch of the background part.
A method for producing a water-soluble packaging which contains a liquid washing or cleaning agent and a water-soluble wrapping which is at least partially colored with a coloring substance selected from the group consisting of pigments, bluing agents, pearlescing agents and mixtures thereof and is made of water-soluble film material, comprising the steps of: a) providing a first water-soluble film web, b) printing the first water-soluble film web with a medium that contains the coloring substance, c) forming at least one cavity in the first water-soluble film web, d) filling the at least one cavity with a product, wherein the product is a liquid washing or cleaning agent, and e) sealing the cavity with a second water-soluble film web, wherein the printing of the first water-soluble film web takes place in such a way that the coloring substance is located on the inner surface of the water-soluble wrapping. a) providing a first water-soluble film web, b) printing the first water-soluble film web with a medium that contains the coloring substance, c) forming at least one cavity in the first water-soluble film web, d) filling the at least one cavity with a product, wherein the product is a liquid washing or cleaning agent, and e) sealing the cavity with a second water-soluble film web,
A load-bearing assembly , comprising: at least one tension member , the at least one tension member comprising a self-fire-resistant resin and reinforcement fibers ; and a jacket material covering the at least one tension member ; characterised in that the self-fire-resistant resin comprises at least one functional group that provides fire-resistant properties and is one of a nitrogen-based and a phosphorus-based functional group. at least one tension member , the at least one tension member comprising a self-fire-resistant resin and reinforcement fibers ; and a jacket material covering the at least one tension member ; characterised in that the self-fire-resistant resin comprises at least one functional group that provides fire-resistant properties and is one of a nitrogen-based and a phosphorus-based functional group.
A method for transmitting data, the method being performed by a user equipment, UE , and comprising: in response to a reception of synchronization information from a network , sending a Chirp requesting UE access data; in response to the Chirp, receiving and saving at least a portion of UE access data; utilizing at least a portion of the saved UE access data to perform more than one data transmission procedure until a predetermined time period, associated with the saved UE access data, expires . in response to a reception of synchronization information from a network , sending a Chirp requesting UE access data; in response to the Chirp, receiving and saving at least a portion of UE access data; utilizing at least a portion of the saved UE access data to perform more than one data transmission procedure until a predetermined time period, associated with the saved UE access data, expires .
A method of operating an ultrasound diagnosis apparatus comprising a processor and a display , the method comprising: obtaining, by the processor, first Doppler data of a blood flow introduced into a right ventricle of an object and second Doppler data of a blood flow discharged from the right ventricle; setting, by the processor, a landmark corresponding to a predetermined motion of a predetermined valve of the right ventricle in each of a first Doppler image generated based on the first Doppler data and a second Doppler image generated based on the second Doppler data; synchronizing, by the processor, the first Doppler image and the second Doppler image based on the set landmark; and displaying, by the display, the first Doppler image and the second Doppler image that are synchronized, wherein the synchronizing of the first Doppler image and the second Doppler image based on the set landmark comprises making a first heartbeat cycle of the object obtained from the first Doppler data in the first Doppler image and a second heartbeat cycle of the object obtained from the second Doppler data in the second Doppler image coincide with each other, and matching times of the predetermined motion of the predetermined valve. obtaining, by the processor, first Doppler data of a blood flow introduced into a right ventricle of an object and second Doppler data of a blood flow discharged from the right ventricle; setting, by the processor, a landmark corresponding to a predetermined motion of a predetermined valve of the right ventricle in each of a first Doppler image generated based on the first Doppler data and a second Doppler image generated based on the second Doppler data; synchronizing, by the processor, the first Doppler image and the second Doppler image based on the set landmark; and displaying, by the display, the first Doppler image and the second Doppler image that are synchronized, wherein the synchronizing of the first Doppler image and the second Doppler image based on the set landmark comprises making a first heartbeat cycle of the object obtained from the first Doppler data in the first Doppler image and a second heartbeat cycle of the object obtained from the second Doppler data in the second Doppler image coincide with each other, and matching times of the predetermined motion of the predetermined valve.
A microfabricated device comprising: a substrate material comprising an array of microwells formed therein, said array of microwells defining at least one gas-entrapping feature on said substrate that entraps gas bubbles upon wetting said array of microwells with an aqueous solvent or solution, wherein the at least one gas-entrapping feature comprises a well, corner, microcavity, dead end, post, trap, hole or combination thereof, and a sacrificial residue being a solid material soluble in said aqueous solvent or solution, wherein said sacrificial residue is comprised of a salt, carbohydrate, or hydrophilic polymer, said sacrificial residue providing a conformal coating in contact with said array of microwells including said at least one gas-entrapping feature, wherein said residue is dissolvable in said aqueous solvent or solution to thereby cause dissolution guided wetting to fill said at least one gas-entrapping feature with said aqueous solvent or solution without entrapping gas bubbles. a substrate material comprising an array of microwells formed therein, said array of microwells defining at least one gas-entrapping feature on said substrate that entraps gas bubbles upon wetting said array of microwells with an aqueous solvent or solution, wherein the at least one gas-entrapping feature comprises a well, corner, microcavity, dead end, post, trap, hole or combination thereof, and a sacrificial residue being a solid material soluble in said aqueous solvent or solution, wherein said sacrificial residue is comprised of a salt, carbohydrate, or hydrophilic polymer, said sacrificial residue providing a conformal coating in contact with said array of microwells including said at least one gas-entrapping feature,
A lead-acid battery comprising: a negative electrode plate; a positive electrode plate; and an electrolyte solution, wherein: the negative electrode plate contains a negative electrode material containing a carbon material and an organic expander; the carbon material contains a first carbon material having a particle size of 32 pm or more, and a second carbon material having a particle size of less than 32 pm; wherein the particle size of each of the carbon materials is determined based on a size of an opening of a sieve as described in the description; a ratio of powder resistance R2 of the second carbon material to powder resistance R1 of the first carbon material: R2/R1 is 15 or more and 155 or less; wherein the powder resistance is measured as described in the description; the first carbon material contains at least graphite, and the second carbon material contains at least carbon black; and a content of the organic expander in the negative electrode material is 0.03 mass% or more and 0.8 mass% or less; characterised in that the organic expander contains lignosulfonic acid or a salt thereof. a negative electrode plate; a positive electrode plate; and an electrolyte solution, wherein: the negative electrode plate contains a negative electrode material containing a carbon material and an organic expander; the carbon material contains a first carbon material having a particle size of 32 pm or more, and a second carbon material having a particle size of less than 32 pm; wherein the particle size of each of the carbon materials is determined based on a size of an opening of a sieve as described in the description; a ratio of powder resistance R2 of the second carbon material to powder resistance R1 of the first carbon material: R2/R1 is 15 or more and 155 or less; wherein the powder resistance is measured as described in the description; the first carbon material contains at least graphite, and the second carbon material contains at least carbon black; and a content of the organic expander in the negative electrode material is 0.03 mass% or more and 0.8 mass% or less; characterised in that the organic expander contains lignosulfonic acid or a salt thereof. the negative electrode plate contains a negative electrode material containing a carbon material and an organic expander; the carbon material contains a first carbon material having a particle size of 32 pm or more, and a second carbon material having a particle size of less than 32 pm; wherein the particle size of each of the carbon materials is determined based on a size of an opening of a sieve as described in the description; a ratio of powder resistance R2 of the second carbon material to powder resistance R1 of the first carbon material: R2/R1 is 15 or more and 155 or less; wherein the powder resistance is measured as described in the description; the first carbon material contains at least graphite, and the second carbon material contains at least carbon black; and a content of the organic expander in the negative electrode material is 0.03 mass% or more and 0.8 mass% or less; characterised in that the organic expander contains lignosulfonic acid or a salt thereof.
A catheter system for delivery of a ureteral catheter in a ureter, comprising: - a ureteral catheter , - a pusher catheter to deliver the ureteral catheter at a desired location, - a connection device, to connect, in an assembled state a distal end of the pusher catheter to a proximal end of the ureteral catheter, characterized in that the catheter system comprises a first contrast agent channel to deliver fluid contrast agent near the distal end of the ureteral catheter and a second contrast agent channel to deliver fluid contrast agent near the proximal end of the ureteral catheter, wherein the first contrast agent channel and the second contrast agent channel are separate channels and wherein the first contrast agent channel and the second contrast agent channel run through the pusher catheter . - a ureteral catheter , - a pusher catheter to deliver the ureteral catheter at a desired location, - a connection device, to connect, in an assembled state a distal end of the pusher catheter to a proximal end of the ureteral catheter, characterized in that