mhurhangee/patent-ind-claim-en huggingface dataset:
A method for producing a monoclonal antibody with specificity toward an antigen of interest, from at least one isolated cell, said method comprising the following steps: fixing a cell population containing antibody-producing cells with a crosslinking reagent, wherein the crosslinking reagent is a reversible crosslinking reagent having the cell membrane permeability (a fixing step); treating the fixed cell population with a detergent to make pores on a cell membrane; reacting the cell population which has been treated with the detergent with a labelled antigen of interest (a staining step); and isolating at least one single cell which has been reacted with the labelled antigen of interest from the cell population that underwent the staining step, preparing a cDNA from mRNA separated from the at least one isolated cell (a cDNA preparing step), wherein the mRNA separation comprises a de-crosslinking treatment of the isolated cell; and preparing the antigen specific monoclonal antibody or fragment thereof from the cDNA obtained in the cDNA preparing step (a preparing step of the monoclonal antibody specific to an antigen of interest), wherein the step and the staining step can be carried out sequentially or in parallel, and characterized in that said mRNA is from said isolated at least one cell. fixing a cell population containing antibody-producing cells with a crosslinking reagent, wherein the crosslinking reagent is a reversible crosslinking reagent having the cell membrane permeability (a fixing step); treating the fixed cell population with a detergent to make pores on a cell membrane; reacting the cell population which has been treated with the detergent with a labelled antigen of interest (a staining step); and isolating at least one single cell which has been reacted with the labelled antigen of interest from the cell population that underwent the staining step, preparing a cDNA from mRNA separated from the at least one isolated cell (a cDNA preparing step), wherein the mRNA separation comprises a de-crosslinking treatment of the isolated cell; and preparing the antigen specific monoclonal antibody or fragment thereof from the cDNA obtained in the cDNA preparing step (a preparing step of the monoclonal antibody specific to an antigen of interest), wherein the step and the staining step can be carried out sequentially or in parallel, and characterized in that said mRNA is from said isolated at least one cell.
Transition body to be arranged between an upper tower section and a lower tower section of a tower for a wind turbine , wherein the lower tower section comprises a central support tower and multiple side towers distributed about the circumference of the central support tower , wherein the transition body is designed as a solid plate body and has means (10, 10.1, 10.2, 11, 11.1, 11.2, 11.3) for connecting to the upper tower section , the lower central support tower and the outer side towers , wherein the transition body consists of multiple segments (8.1, 8.2, 8.3), characterized in that the transition body is composed of several layers (9.1, 9.2, 9.3) of segments (8.1, 8.2, 8.3).
A method for wireless communications performed by a user equipment, UE, comprising: powering on a communication component of the UE; identifying an absence of a subscriber identity module, SIM, profile for communications with a wireless network while the UE is provided with a SIM card for connecting the UE to the network; determining a provider-specific configuration for communications with the wireless network; generating a set of SIM configuration parameters for a registration procedure with the wireless network based at least in part on identifying the absence of the SIM profile and the provider-specific configuration; generating a globally unique temporary identifier based at least in part on the SIM configuration parameters; and performing the registration procedure with the wireless network using the set of SIM configuration parameters and the globally unique temporary identifier. powering on a communication component of the UE; identifying an absence of a subscriber identity module, SIM, profile for communications with a wireless network while the UE is provided with a SIM card for connecting the UE to the network; determining a provider-specific configuration for communications with the wireless network; generating a set of SIM configuration parameters for a registration procedure with the wireless network based at least in part on identifying the absence of the SIM profile and the provider-specific configuration; generating a globally unique temporary identifier based at least in part on the SIM configuration parameters; and performing the registration procedure with the wireless network using the set of SIM configuration parameters and the globally unique temporary identifier.
A method, executed in a delivery node , for optimizing delivery of a content in a content delivery network, comprising: - receiving a request for the content ; - obtaining a determination of whether or not a category of content is associated with the requested content ; - responsive to the determination that a category of content is associated with the requested content, redirecting the request to a delivery node serving content associated with the category; and - responsive to the determination that no category of content is associated with the requested content, forwarding the request for the content towards an origin server and upon receiving a response from the origin server serving the content . - receiving a request for the content ; - obtaining a determination of whether or not a category of content is associated with the requested content ; - responsive to the determination that a category of content is associated with the requested content, redirecting the request to a delivery node serving content associated with the category; and - responsive to the determination that no category of content is associated with the requested content, forwarding the request for the content towards an origin server and upon receiving a response from the origin server serving the content .
A medical optical system, comprising: an optical connector system arranged to provide a reversible optical connection between associated first and second optical fibers , each comprising multiple fiber cores, the optical connector system comprising: - a first ferrule with an outer body and arranged for having an end portion of the associated first optical fiber arranged inside, - a second ferrule with an outer body and arranged for having an end portion of the associated second optical fiber arranged inside, - a receptacle arrangement comprising a receiving body , wherein the receptacle arrangement is arranged to receive an end part of the outer body of at least the second ferrule , wherein the receptacle arrangement further comprises an optical element serving to provide an optical connection between the associated first and second optical fibers in a connected state of the optical connector system, and wherein the optical element serves as a sterility barrier between the associated first and second optical fibers , the optical connector system being configured for rotational alignment of the first and second optical fibers in the connected state of the connector system, wherein the optical element provides connection between each single fiber core of the first and second optical fibers , and - a rotational locking arrangement preventing relative rotation between the first and second ferrules . - a first ferrule with an outer body and arranged for having an end portion of the associated first optical fiber arranged inside, - a second ferrule with an outer body and arranged for having an end portion of the associated second optical fiber arranged inside, - a receptacle arrangement comprising a receiving body , wherein the receptacle arrangement is arranged to receive an end part of the outer body of at least the second ferrule , wherein the receptacle arrangement further comprises an optical element serving to provide an optical connection between the associated first and second optical fibers in a connected state of the optical connector system, and wherein the optical element serves as a sterility barrier between the associated first and second optical fibers , the optical connector system being configured for rotational alignment of the first and second optical fibers in the connected state of the connector system, wherein the optical element provides connection between each single fiber core of the first and second optical fibers , and - a rotational locking arrangement preventing relative rotation between the first and second ferrules .
A composition for a non-aqueous secondary battery functional layer, the composition comprising: a polymer; inorganic particles; and a solvent, wherein: the polymer is a block copolymer including an aromatic vinyl monomer unit and an aliphatic conjugated diene monomer unit; and the polymer has a diblock content of 5 mass% or more and 85 mass% or less, wherein the diblock content is measured as disclosed in the description. the polymer is a block copolymer including an aromatic vinyl monomer unit and an aliphatic conjugated diene monomer unit; and the polymer has a diblock content of 5 mass% or more and 85 mass% or less,
A method for controlling the break operation of a switching device , the method comprising: instructing, using a pulse-width modulated signal , a switch to supply a break current to an operating coil of the switching device to break the switching device; characterised by determining, using a control circuitry, when a duty cycle of the pulse-width modulated signal is at a minimum determined value; subsequently, determining, using the control circuitry, a duration the duty cycle of the pulse-width modulated signal goes above the minimum determined value; and determining, using the control circuitry, when the switching device breaks based at least in part on the duration the duty cycle is above the minimum determined value after reaching the minimum determined value, wherein when the switching device breaks is used to control future break operations of the switching device by: updating an expected break time look-up table with the duration the duty cycle is above the minimum determined value, or using the determined expected break time to break the switching device ahead of a current zero-crossing during future break operations. instructing, using a pulse-width modulated signal , a switch to supply a break current to an operating coil of the switching device to break the switching device; characterised by determining, using a control circuitry, when a duty cycle of the pulse-width modulated signal is at a minimum determined value; subsequently, determining, using the control circuitry, a duration the duty cycle of the pulse-width modulated signal goes above the minimum determined value; and determining, using the control circuitry, when the switching device breaks based at least in part on the duration the duty cycle is above the minimum determined value after reaching the minimum determined value, wherein when the switching device breaks is used to control future break operations of the switching device by: updating an expected break time look-up table with the duration the duty cycle is above the minimum determined value, or using the determined expected break time to break the switching device ahead of a current zero-crossing during future break operations. updating an expected break time look-up table with the duration the duty cycle is above the minimum determined value, or using the determined expected break time to break the switching device ahead of a current zero-crossing during future break operations.
A light receiver having a plurality of avalanche photodiode elements that each can be biased at a bias voltage above a breakdown voltage and thus is operable in a Geiger mode, the avalanche photodiode elements forming a plurality of groups that respectively generate a photocurrent upon light reception, and having a plurality of readout circuits for reading out a group of avalanche photodiode elements , each comprising an active coupling element having an input for a photocurrent, a control terminal and an output for a measurement current corresponding to the photocurrent, wherein the readout circuits are connected together on the output side in order to combine the measurement currents to form a common measurement signal (RX out ), characterized in that the light receiver comprises a selection circuit usable to selectively apply a control signal to the control terminal so that the coupling element , depending on the control signal , is or is not activated and thus contributes a measurement current to the common measurement signal (RX out ).
A compound of the formula (X-2): or a pharmaceutically acceptable salt, solvate, hydrate, polymorph crystal or amorphous forms, thereof, wherein: Z 3 represents a structure of formula (XI-1) or formula (XI-3): Y 3 is NR; R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; each Ra 1 and Ra 2 independently is H, aliphatic, or aromatic substitution group; each Ra 3 and Ra 4 independently is H, aliphatic, or aromatic substitution group; q is 0, 1, or 2; and r is 0, 1, or 2. Z 3 represents a structure of formula (XI-1) or formula (XI-3): Y 3 is NR; R represents an aliphatic or aromatic group with or without heteroatom or functional group, such as COOH, OH, or NH 2 ; each Ra 1 and Ra 2 independently is H, aliphatic, or aromatic substitution group; each Ra 3 and Ra 4 independently is H, aliphatic, or aromatic substitution group; q is 0, 1, or 2; and r is 0, 1, or 2.
A yarn winding machine comprising: a package driving section adapted to rotationally drive a package ; a traverse device adapted to traverse a yarn to be wound into the package ; and a control section adapted to control the traverse device to perform creeping, characterized in that after a first yarn layer is formed by winding the yarn into the package while performing the creeping under a first creeping rate, a second yarn layer, being a surface yarn layer is formed by winding the yarn into the package while performing the creeping under a second creeping rate that is lower than the first creeping rate, or while performing no creeping; and by comprising a timing setting section adapted to set a timing to start forming the second yarn layer ; wherein the timing setting section is adapted to set as the timing, a point of time when a yarn layer thickness of the package is at least 90% and less than 100% of a target yarn layer thickness, a point of time when a diameter of the package is at least 90% and less than 100% of a target package diameter, or a point of time when a wound length of the yarn that has been wound into the package is at least 90% and less than 100% of a target winding length. a package driving section adapted to rotationally drive a package ; a traverse device adapted to traverse a yarn to be wound into the package ; and a control section adapted to control the traverse device to perform creeping, characterized in that after a first yarn layer is formed by winding the yarn into the package while performing the creeping under a first creeping rate, a second yarn layer, being a surface yarn layer is formed by winding the yarn into the package while performing the creeping under a second creeping rate that is lower than the first creeping rate, or while performing no creeping; and by comprising a timing setting section adapted to set a timing to start forming the second yarn layer ; wherein the timing setting section is adapted to set as the timing, a point of time when a yarn layer thickness of the package is at least 90% and less than 100% of a target yarn layer thickness, a point of time when a diameter of the package is at least 90% and less than 100% of a target package diameter, or a point of time when a wound length of the yarn that has been wound into the package is at least 90% and less than 100% of a target winding length.
A thermoplastic composition comprising: 30 wt. % to 70 wt. % of a semi-crystalline polyester; 10 wt. % to 50 wt. % of a halogenated polycarbonate; 3 wt. % to 25 wt. % of a first poly(carbonate-siloxane) copolymer having a siloxane content of less than 30 wt. %, wherein the siloxane content is based on the total weight of the first poly(carbonate-siloxane) copolymer; and 3 wt. % to 25 wt. % of a second poly(carbonate-siloxane) copolymer having a siloxane content of greater than 30 wt. %, wherein the siloxane content is based on the total weight of the second poly(carbonate-siloxane) copolymer, wherein the composition has a UL94 rating of V0 at a thickness of 1.5 mm, and wherein an ASTM tensile bar comprising the composition has a tensile strength retention of at least 80% after exposure of the bar for 168 hours to SANI-CLOTH AF3 at a temperature of 23°C under 0.5% or 1% strain compared to a non-exposed reference tested at the same condition, and a tensile elongation retention of at least 65% after exposure of the bar for 168 hours to SANI-CLOTH AF3 at a temperature of 23°C under 0.5% or 1% strain compared to a non-exposed reference tested at the same condition. 30 wt. % to 70 wt. % of a semi-crystalline polyester; 10 wt. % to 50 wt. % of a halogenated polycarbonate; 3 wt. % to 25 wt. % of a first poly(carbonate-siloxane) copolymer having a siloxane content of less than 30 wt. %, wherein the siloxane content is based on the total weight of the first poly(carbonate-siloxane) copolymer; and 3 wt. % to 25 wt. % of a second poly(carbonate-siloxane) copolymer having a siloxane content of greater than 30 wt. %, wherein the siloxane content is based on the total weight of the second poly(carbonate-siloxane) copolymer, wherein the composition has a UL94 rating of V0 at a thickness of 1.5 mm, and wherein an ASTM tensile bar comprising the composition has a tensile strength retention of at least 80% after exposure of the bar for 168 hours to SANI-CLOTH AF3 at a temperature of 23°C under 0.5% or 1% strain compared to a non-exposed reference tested at the same condition, and a tensile elongation retention of at least 65% after exposure of the bar for 168 hours to SANI-CLOTH AF3 at a temperature of 23°C under 0.5% or 1% strain compared to a non-exposed reference tested at the same condition.
A device especially adapted for feeding and entertaining a large animal, such as a horse, said device comprising: a body made of a flexible and elastomeric material, said body having an outer peripheral edge and an inner peripheral edge defining a central opening ; at least one through hole formed through the device; and at least one groove formed through a selected surface of the device, wherein said through hole and said groove are configured for frictionally holding feed or treats for the animals and wherein one through hole of said at least one through hole is spaced radially inward from said at least one groove . a body made of a flexible and elastomeric material, said body having an outer peripheral edge and an inner peripheral edge defining a central opening ; at least one through hole formed through the device; and at least one groove formed through a selected surface of the device, wherein said through hole and said groove are configured for frictionally holding feed or treats for the animals and wherein one through hole of said at least one through hole is spaced radially inward from said at least one groove .
A method for wireless communication, comprising: transmitting downlink control information for a first user equipment, UE , based at least in part on a group identifier associated with a non-orthogonal multiple access, NOMA, group comprising the first UE and at least a second UE (215-a, 315-a, 415-a, 2015-a, 2215-a, 2315-a, 2415-a, 2515-a, 2615-a, 2715-a); and transmitting a set of NOMA downlink transmissions to the first UE based at least in part on the downlink control information for the first UE , characterized in that the transmitted downlink control information for the first UE is based at least in part on a deterministic function of the group identifier and a first UE identifier assigned to the first UE , wherein the deterministic function comprises an exclusive-OR function. transmitting downlink control information for a first user equipment, UE , based at least in part on a group identifier associated with a non-orthogonal multiple access, NOMA, group comprising the first UE and at least a second UE (215-a, 315-a, 415-a, 2015-a, 2215-a, 2315-a, 2415-a, 2515-a, 2615-a, 2715-a); and transmitting a set of NOMA downlink transmissions to the first UE based at least in part on the downlink control information for the first UE , characterized in that the transmitted downlink control information for the first UE is based at least in part on a deterministic function of the group identifier and a first UE identifier assigned to the first UE , wherein the deterministic function comprises an exclusive-OR function.
An immunotoxin comprising a single chain variable region antibody fused to a PE38 truncated Pseudomonas exotoxin, wherein the single chain variable region antibody has the carboxyl terminus of the V H domain shown in SEQ ID NO: 1 connected to the amino terminus of the V L domain shown in SEQ ID NO: 3 by peptide linker (Gly 4 Ser) 3 , and is capable of reacting to the wild type and variant III epidermal growth factor receptor (EGFR), and an immune checkpoint inhibitor selected from the group consisting of an anti-PD-1 antibody, an anti-PD-L1 antibody, an anti-CTLA4 antibody, an anti-LAG-3 antibody, an anti-TIM-3 antibody, and an anti-CSF- 1R antibody, for use in treating a tumor that expresses on its surface wild type and/or variant III of epidermal growth factor receptor (EGFR) in a patient, wherein the immune checkpoint inhibitor is administered at the same time, before, or after the immunotoxin, and the immunotoxin and the immune checkpoint inhibitor are administered within 30 days of each other.
An arrangement for installations of monitoring sensors of a vessel 1 for treatment of lignocellulosic material, which vessel has a central pipe comprising one or more concentric pipes for delivery of fluids into to the vessel, which concentric pipes are mounted coaxially within the vessel , characterized in that at least one sensor channel is arranged along the outermost wall of the concentric pipes of the central pipe and that the at least one sensor channel is connected to a cable conduit , which cable conduit connects the exterior of the vessel to the at least one sensor channel and the sensor channel is several meters long and has plurality of holders for sensors and/or is configured to contain plurality of thermal sensors with their cables .