mhurhangee/patent-ind-claim-en huggingface dataset:
The process for preparation of deoxycholic acid (DCA) or a pharmaceutically acceptable salt thereof, comprising the following steps: i) providing a compound of the general formula SM-a: ii) reducing the compound of the general formula SM-a to obtain an intermediate of the general formula Int A1: iii) converting the intermediate of the general formula Int A1 into an intermediate of the general formula Int A2: iv) reducing the intermediate of the general formula Int A2 into an intermediate of the general formula Int A3: v) oxidising the intermediate of the general formula Int A3 into an intermediate of the general formula Int A5: vi) reducing the intermediate of the general formula Int A5 into an intermediate of the general formula Int A6: vii) reducing the intermediate of the general formula Int A6 into an intermediate of the general formula Int A7: viii) reducing the compound of the general formula Int A7 into an intermediate of the general formula Int A8: or elongating the carbon chain of the intermediate of the general formula Int A7 into an intermediate of the general formula Int B2: wherein R 2 is a linear or branched C 1 -C 6 -alkyl group, ix) elongating the carbon chain of the compound of the general formula Int A8 or converting the intermediate of the general formula Int B2 to obtain deoxycholic acid (DCA): x) optionally converting deoxycholic acid to a pharmaceutically acceptable salt thereof, wherein R 2 is H or a linear or branched C 1 -C 6 -alkyl group; R3 is H, R 2 or an alcohol protection group. i) providing a compound of the general formula SM-a: ii) reducing the compound of the general formula SM-a to obtain an intermediate of the general formula Int A1: iii) converting the intermediate of the general formula Int A1 into an intermediate of the general formula Int A2: iv) reducing the intermediate of the general formula Int A2 into an intermediate of the general formula Int A3: v) oxidising the intermediate of the general formula Int A3 into an intermediate of the general formula Int A5: vi) reducing the intermediate of the general formula Int A5 into an intermediate of the general formula Int A6: vii) reducing the intermediate of the general formula Int A6 into an intermediate of the general formula Int A7: viii) reducing the compound of the general formula Int A7 into an intermediate of the general formula Int A8: or elongating the carbon chain of the intermediate of the general formula Int A7 into an intermediate of the general formula Int B2: wherein R 2 is a linear or branched C 1 -C 6 -alkyl group, ix) elongating the carbon chain of the compound of the general formula Int A8 or converting the intermediate of the general formula Int B2 to obtain deoxycholic acid (DCA): x) optionally converting deoxycholic acid to a pharmaceutically acceptable salt thereof, wherein R 2 is H or a linear or branched C 1 -C 6 -alkyl group; R3 is H, R 2 or an alcohol protection group. R 2 is H or a linear or branched C 1 -C 6 -alkyl group; R3 is H, R 2 or an alcohol protection group.
A nucleic acid construct comprising: a nucleic acid encoding a transcriptional activator operably linked to an inducible promoter element, wherein the transcriptional activator induces the inducible promoter element, and wherein the transcriptional activator is selected from the group consisting of methanol expression regulator 1 (Mxr1) from Pichia Pastoris, alcohol dehydrogenase regulator 1 (Adr1) from Hansenula polymorpha, transcriptional regulation of methanol induction 1 (Trm1) from Candida boidinii, and transcriptional regulation of methanol induction 2 (Trm2) from Candida boidinii. a nucleic acid encoding a transcriptional activator operably linked to an inducible promoter element, wherein the transcriptional activator induces the inducible promoter element, and wherein the transcriptional activator is selected from the group consisting of methanol expression regulator 1 (Mxr1) from Pichia Pastoris, alcohol dehydrogenase regulator 1 (Adr1) from Hansenula polymorpha, transcriptional regulation of methanol induction 1 (Trm1) from Candida boidinii, and transcriptional regulation of methanol induction 2 (Trm2) from Candida boidinii.
A surgical system comprising: a surgical console configured to operate a surgical device and comprising a connection port ; a control device configured to communicate with the surgical console to remotely control the surgical device and comprising a first communication device and a radio frequency ,RF, reader , wherein the control device is further defined as a foot-operable control device, a hand-operable control device, or a mobile computing device; a dongle configured to physically couple to the connection port of the surgical console and comprising a second communication device and a passive RF device , wherein the dongle is configured to be powered through the connection port of the surgical console ; wherein the RF reader of the control device is configured to receive pairing information from the passive RF device of the dongle in response to the passive RF device being within a threshold proximity of the RF reader ; and wherein the first and second communication devices are configured to wirelessly connect based on the pairing information to thereby enable the control device to wirelessly communicate with the surgical console to remotely control the surgical device . a surgical console configured to operate a surgical device and comprising a connection port ; a control device configured to communicate with the surgical console to remotely control the surgical device and comprising a first communication device and a radio frequency ,RF, reader , wherein the control device is further defined as a foot-operable control device, a hand-operable control device, or a mobile computing device; a dongle configured to physically couple to the connection port of the surgical console and comprising a second communication device and a passive RF device , wherein the dongle is configured to be powered through the connection port of the surgical console ; wherein the RF reader of the control device is configured to receive pairing information from the passive RF device of the dongle in response to the passive RF device being within a threshold proximity of the RF reader ; and wherein the first and second communication devices are configured to wirelessly connect based on the pairing information to thereby enable the control device to wirelessly communicate with the surgical console to remotely control the surgical device .
Transport bag (10; 10.1-10.5) for transport of an item for transport in a hanging manner by means of a transport device (23; 23') extending in a transport direction , which transport bag (10; 10.1-10.5) has a rear wall which is oriented transversely to the transport direction and has a front wall which is oriented transversely to the transport direction , which walls are connected movably with respect to one another at an upper bag termination and a lower bag termination such that the front wall relative to the rear wall between a full position, in which it is at a first distance (d1) from the rear wall , and an empty position, in which it is at a second distance (d2) from the rear wall , which second distance is smaller than the first distance (d1), and which transport bag (10; 10.1-10.5) can be connected in a hanging manner to the transport device (23; 23') by means of a connecting means (13; 13'; 13") which is attached to the top of the rear wall , characterized in that , in the region of the lower bag termination , the rear wall has laterally arranged first localized guide elements for guidance of the transport bag (10; 10.1-10.5).
A method performed by a wireless device for transmitting channel state information, CSI, feedback using a new radio, NR, Type II multi-beam precoder codebook, wherein the CSI feedback is of a NR Release 16 enhanced Type II, the method comprising: obtaining a configuration for a sub-band channel quality indicator, CQI, granularity and a sub-band precoding matrix indicator, PMI, granularity for the wireless device, wherein the sub-band PMI granularity corresponds to a first sub-band size and the sub-band CQI granularity corresponds to a second sub-band size, and wherein the first sub-band size is smaller than the second sub-band size; determining the CSI feedback according to the configured sub-band CQI granularity and the sub-band PMI granularity, wherein the CSI feedback indicates a linear combination of precoder vectors, wherein the precoder vectors are discrete Fourier transform, DFT, precoder vectors, wherein the precoder vectors correspond to respective frequency sub-bands having the first sub-band size, wherein the coefficients for the precoder vectors in the linear combination of precoder vectors are parameterized in the frequency-domain as a linear combination of a set of basis vectors and a set of coefficients for the basis vectors in the linear combination of the set of basis vectors; and transmitting , to a network node , the determined CSI feedback. obtaining a configuration for a sub-band channel quality indicator, CQI, granularity and a sub-band precoding matrix indicator, PMI, granularity for the wireless device, wherein the sub-band PMI granularity corresponds to a first sub-band size and the sub-band CQI granularity corresponds to a second sub-band size, and wherein the first sub-band size is smaller than the second sub-band size; determining the CSI feedback according to the configured sub-band CQI granularity and the sub-band PMI granularity, wherein the CSI feedback indicates a linear combination of precoder vectors, wherein the precoder vectors are discrete Fourier transform, DFT, precoder vectors, wherein the precoder vectors correspond to respective frequency sub-bands having the first sub-band size, wherein the coefficients for the precoder vectors in the linear combination of precoder vectors are parameterized in the frequency-domain as a linear combination of a set of basis vectors and a set of coefficients for the basis vectors in the linear combination of the set of basis vectors; and transmitting , to a network node , the determined CSI feedback.
Means for distribution of fog or steam from a first inlet (E) to different first outlets (A) at which respectively at least one line can be attached, - having a single-part or multiple-part first container , - which has an opening for the first inlet (E) for supplying a fog or gas flow transporting steam and - which in a second wall has openings for the first outlets (A), - having a single-part or multiple-part locking element which is movably disposed in the container , - wherein the locking element has at least one hole (L) which can be brought by means of a movement of the locking element at least partially into overlap with at least one of the first outlets (A) or out of overlap with at least one of the first outlets (A), in order to expose or to close this first outlet (A) - wherein the first container has a tub or a pot and a lid closing the tub or the pot , characterised in - that a floor of the tub or of the pot has the opening for the first inlet (E) and the lid has the openings for the first outlets (A) or that the floor of the tub or of the pot has the openings for the first outlets (A) and the lid has the opening for the first inlet (E). - having a single-part or multiple-part first container , - which has an opening for the first inlet (E) for supplying a fog or gas flow transporting steam and - which in a second wall has openings for the first outlets (A), - having a single-part or multiple-part locking element which is movably disposed in the container , - wherein the locking element has at least one hole (L) which can be brought by means of a movement of the locking element at least partially into overlap with at least one of the first outlets (A) or out of overlap with at least one of the first outlets (A), in order to expose or to close this first outlet (A) - wherein the first container has a tub or a pot and a lid closing the tub or the pot , characterised in - that a floor of the tub or of the pot has the opening for the first inlet (E) and the lid has the openings for the first outlets (A) or that the floor of the tub or of the pot has the openings for the first outlets (A) and the lid has the opening for the first inlet (E).
A neutron detector, comprising: - a core , rich in gadolinium or cadmium, - a plastic scintillator shell , which envelops the core , and - a photon conversion device which has an interface with the shell and which converts scintillation photons from the shell into a signal representative thereof, characterized in that it further comprises a scintillator layer containing boron or lithium, which surrounds the shell . - a core , rich in gadolinium or cadmium, - a plastic scintillator shell , which envelops the core , and - a photon conversion device which has an interface with the shell and which converts scintillation photons from the shell into a signal representative thereof,
A transport vehicle comprising a tractor and a trailer , which can be fixed to the tractor , wherein the tractor has at least one front axle and at least one rear axle as well as a machine frame arranged above the rear axle , wherein the trailer has at least one trailer axle and a loading area arranged above the trailer axle , wherein at least three, preferably at least four, and in particular four fixing elements for fixing the trailer to the tractor are provided on the machine frame of the tractor , wherein at least three, preferably at least four, and in particular four complementary fixing elements are present on the trailer , and wherein each complementary fixing element of the trailer can be fixed or is fixed, respectively, to a fixing element of the tractor , characterized in that the connection or the fixation, respectively, between the fixing elements and the complementary fixing elements is formed as twist-lock locking mechanism or as twist-lock container locking mechanism, respectively. wherein at least three, preferably at least four, and in particular four fixing elements for fixing the trailer to the tractor are provided on the machine frame of the tractor , wherein at least three, preferably at least four, and in particular four complementary fixing elements are present on the trailer , and wherein each complementary fixing element of the trailer can be fixed or is fixed, respectively, to a fixing element of the tractor , characterized in that the connection or the fixation, respectively, between the fixing elements and the complementary fixing elements is formed as twist-lock locking mechanism or as twist-lock container locking mechanism, respectively.
An asphalt modifier, comprising a biorenewable oil and a thermoplastic polymer, wherein the thermoplastic polymer comprises about 1-75 wt% with a remaining balance of a biorenewable oil, wherein the biorenewable oil is soybean oil, wherein the biorenewable oil is at least partially sulfurized, and wherein the thermoplastic polymer is a styrene-butadiene block copolymer. wherein the biorenewable oil is soybean oil, wherein the biorenewable oil is at least partially sulfurized, and wherein the thermoplastic polymer is a styrene-butadiene block copolymer.
A network transmission method, wherein the method is used to transmit data by using a plurality of subflows, and the method comprises: determining at least one network status parameter of the plurality of subflows; and when at least one network status parameter of at least two of the plurality of subflows satisfies a preset condition, performing aggregated transmission for the data by using the at least two subflows, wherein the aggregated transmission means that one data packet is sent by using only one of the at least two subflows, and data packets sent by using different subflows of the at least two subflows are different from each other; and when a sum of transmission rates of the aggregated transmission is less than or equal to a corresponding threshold, performing redundant transmission for the data separately by using the at least two subflows, wherein the redundant transmission means that data packets are sent by using all of the at least two subflows, and the data packets sent by using all of the at least two subflows are the same. determining at least one network status parameter of the plurality of subflows; and when at least one network status parameter of at least two of the plurality of subflows satisfies a preset condition, performing aggregated transmission for the data by using the at least two subflows, wherein the aggregated transmission means that one data packet is sent by using only one of the at least two subflows, and data packets sent by using different subflows of the at least two subflows are different from each other; and when a sum of transmission rates of the aggregated transmission is less than or equal to a corresponding threshold, performing redundant transmission for the data separately by using the at least two subflows, wherein the redundant transmission means that data packets are sent by using all of the at least two subflows, and the data packets sent by using all of the at least two subflows are the same.
A method of detecting a target object, the method comprising; receiving a left image taken by a stereo camera ; and receiving a right image taken by the stereo camera; characterized by offsetting the left image and the right image relative to one another by an offset disparity to produce offset left and right images , wherein the offset disparity is derived from an assumed distance between the stereo camera and the target object, to remove the disparity in the offset left and right images between depictions of any object appearing at the assumed distance from the stereo camera; and locating the target object in the offset left and right images, wherein locating the target object comprises: applying (402/404) a machine-learning trained classifier (500; 502) to the offset left image to determine a first confidence of object detection for each pixel in the offset left image; applying (404/402) the machine-learning trained classifier (500; 502) to the offset right image to determine a second confidence of object detection for each pixel in the offset right image; combining (406; 700) the correlated confidences of object detection in the offset left and right images to yield a combined confidence of object detection for each corresponding pixel in the offset first and second images; and determining a candidate region in one or both of the offset left and right images that includes the target object, whereby the pixels in the candidate region fulfil the following conditions: the combined confidence is not less than a threshold confidence, and the difference between correlated confidences of first and second images is not greater than a threshold. applying (402/404) a machine-learning trained classifier (500; 502) to the offset left image to determine a first confidence of object detection for each pixel in the offset left image; applying (404/402) the machine-learning trained classifier (500; 502) to the offset right image to determine a second confidence of object detection for each pixel in the offset right image; combining (406; 700) the correlated confidences of object detection in the offset left and right images to yield a combined confidence of object detection for each corresponding pixel in the offset first and second images; and determining a candidate region in one or both of the offset left and right images that includes the target object, whereby the pixels in the candidate region fulfil the following conditions: the combined confidence is not less than a threshold confidence, and the difference between correlated confidences of first and second images is not greater than a threshold.
A liquid ejecting apparatus which ejects liquid onto a medium, the liquid ejecting apparatus comprising: a carriage which includes a control substrate configuring at least a part of a control unit which controls driving of the entire liquid ejecting apparatus , an ejecting unit which ejects the liquid, and a driving substrate which is connected to the control substrate and the ejecting unit , and drives the ejecting unit , wherein the carriage is provided with a fixing unit which fixes a position of the driving substrate with respect to a position of the ejecting unit , characterized in that the fixing unit is provided on the upper side of the driving substrate , in the carriage . a carriage which includes a control substrate configuring at least a part of a control unit which controls driving of the entire liquid ejecting apparatus , an ejecting unit which ejects the liquid, and a driving substrate which is connected to the control substrate and the ejecting unit , and drives the ejecting unit , wherein the carriage is provided with a fixing unit which fixes a position of the driving substrate with respect to a position of the ejecting unit , characterized in that the fixing unit is provided on the upper side of the driving substrate , in the carriage .
An industrial truck comprising, a tiller arm for maneuvering the industrial truck , a load carrier , an horizontal pivot angle sensor , a control unit , an hydraulic system for operating the load carrier , wherein the control unit operable to control functions of the industrial truck including travel and lifting function, wherein the angle sensor is operable to detect the horizontal pivot angle (α) of the tiller arm around a vertical axis , wherein the load carrier is operable to be maneuvered to an elevated position, wherein the industrial truck is arranged such that the angle sensor can send detected pivot angle (α) values to the control unit , wherein the industrial truck is arranged such that control unit is operable to communicate with and control the hydraulic system of the industrial truck , characterised in that , the control unit is arranged such that when the pivot angle (α) of the tiller arm is determined by the sensor to be within a first predetermined range of pivot angles (α1-α2), the control unit controls the hydraulic system such that lowering of load carrier is disabled. the industrial truck is arranged such that the angle sensor can send detected pivot angle (α) values to the control unit , wherein the industrial truck is arranged such that control unit is operable to communicate with and control the hydraulic system of the industrial truck , characterised in that , the control unit is arranged such that when the pivot angle (α) of the tiller arm is determined by the sensor to be within a first predetermined range of pivot angles (α1-α2), the control unit controls the hydraulic system such that lowering of load carrier is disabled.
A sealing arrangement for sealing between an aft frame of a combustor and a stage-one nozzle of a gas turbine within a high pressure plenum that at least partially surrounds various components of the combustor , the sealing arrangement comprising a seal comprising a flexible sealing element , the flexible sealing element comprising an intermediate portion , a first outer portion on one side of the intermediate portion , and a second outer portion on the other side of the intermediate portion ; wherein the intermediate portion is mechanically loaded against the aft frame and the stage-one nozzle , characterised in that the first outer portion and the second outer portion are pressure-loaded against the aft frame and the stage-one nozzle by a compressed working fluid within the high pressure plenum .