mhurhangee/patent-ind-claim-en huggingface dataset:
A hair oil applicator comprising: (a) a container comprising a base , upwardly extending walls therefrom, threaded portion at the upper end of the container and a top surface comprising a flat resilient member ; (b) a closure cum dispenser comprising a cylindrical cap , said cap comprising counter threads on the inner side thereof capable of screw engagement with the threaded portion of the container; (c) said cylindrical cap comprising an elongated horizontally placed distributor tube on the top surface thereof; and said distributor tube comprising plurality of upwardly extending nozzles configured to dispense the oil from the container; wherein the resilient member comprises an upwardly extending breakable tab which when broken ensures that the distributor tube is in fluid communication with the oil in the container; and said cylindrical cap comprising an inner cylindrical stopper and an outer cylindrical stopper on the inner side thereof; said inner cylindrical stopper capable of providing leakproof sealing for the oil when the closure-cum-dispenser is screwed on tightly to the container ; and said outer cylindrical stopper capable of sitting flush against the perimeter of the top surface; thereby ensuring that the hair oil applicator is leak-proof around the threaded joints; and providing uniform dispensing of the oil through the nozzles . (a) a container comprising a base , upwardly extending walls therefrom, threaded portion at the upper end of the container and a top surface comprising a flat resilient member ; (b) a closure cum dispenser comprising a cylindrical cap , said cap comprising counter threads on the inner side thereof capable of screw engagement with the threaded portion of the container; (c) said cylindrical cap comprising an elongated horizontally placed distributor tube on the top surface thereof; and said distributor tube comprising plurality of upwardly extending nozzles configured to dispense the oil from the container; the resilient member comprises an upwardly extending breakable tab which when broken ensures that the distributor tube is in fluid communication with the oil in the container; and said cylindrical cap comprising an inner cylindrical stopper and an outer cylindrical stopper on the inner side thereof; said inner cylindrical stopper capable of providing leakproof sealing for the oil when the closure-cum-dispenser is screwed on tightly to the container ; and said outer cylindrical stopper capable of sitting flush against the perimeter of the top surface; thereby ensuring that the hair oil applicator is leak-proof around the threaded joints; and providing uniform dispensing of the oil through the nozzles .
A modular burner comprising a plurality of mixer modules positioned side by side and parallel to a longitudinal plane (Y), each of which has a length (L) measured parallel to the longitudinal plane (Y), wherein each mixer module comprises: a flow conduit provided with an inlet opening and a plurality of outlet openings arranged on an emission surface ; wherein the emission surfaces lie in an emission plane of the burner; wherein each emission surface has a width (D), measured perpendicularly to the longitudinal plane (Y), and wherein two adjacent emission surfaces are separated by a distance (S), measured perpendicularly to the longitudinal plane (Y); wherein the ratio between the distance (S) and the width (D) is comprised between 0.4 and 0.7; characterised in that: it comprises a rear bracket provided with a main portion having a plurality of through openings , wherein the through openings have an overall area A, characterised in that a nondimensional parameter K: K = A N − 1 S 2 is greater than 4, where N is the overall number of mixer modules and s is the distance (S) separating two adjacent emission surfaces . a flow conduit provided with an inlet opening and a plurality of outlet openings arranged on an emission surface ; wherein the emission surfaces lie in an emission plane of the burner; wherein each emission surface has a width (D), measured perpendicularly to the longitudinal plane (Y), and wherein two adjacent emission surfaces are separated by a distance (S), measured perpendicularly to the longitudinal plane (Y); wherein the ratio between the distance (S) and the width (D) is comprised between 0.4 and 0.7; characterised in that: it comprises a rear bracket provided with a main portion having a plurality of through openings , wherein the through openings have an overall area A, characterised in that a nondimensional parameter K: K = A N − 1 S 2 is greater than 4, where N is the overall number of mixer modules and s is the distance (S) separating two adjacent emission surfaces .
An antigen binding construct for use in a method of inhibiting tumor growth in a human subject, wherein the antigen binding construct comprises a first antigen-binding polypeptide construct which monovalently and specifically binds a HER2 (human epidermal growth factor receptor 2) ECD2 (extracellular domain 2) antigen on a HER2-expressing cell and a second antigen-binding polypeptide construct which monovalently and specifically binds a HER2 ECD4 (extracellular domain 4) antigen on a HER2-expressing cell, wherein the first antigen-binding polypeptide construct is operably linked to a first linker polypeptide and the second antigen-binding polypeptide construct is operably linked to a second linker polypeptide, wherein the first and second linker polypeptides are covalently linked with each other, and wherein the linker polypeptides are operatively linked to a human IgG1 Fc region, wherein the first antigen-binding polypeptide construct is a Fab, wherein the Fab-linker-IgG1 Fc comprises a heavy chain comprising SEQ ID NO:97 and a light chain comprising SEQ ID NO:69, and wherein the second antigen-binding polypeptide construct is an scFv, wherein the scFv-linker-IgG1 Fc comprises SEQ ID NO:295, and wherein the human subject is administered at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 doses of the antigen binding construct, and/or wherein each dose is administered at least every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 days. wherein the antigen binding construct comprises a first antigen-binding polypeptide construct which monovalently and specifically binds a HER2 (human epidermal growth factor receptor 2) ECD2 (extracellular domain 2) antigen on a HER2-expressing cell and a second antigen-binding polypeptide construct which monovalently and specifically binds a HER2 ECD4 (extracellular domain 4) antigen on a HER2-expressing cell, wherein the first antigen-binding polypeptide construct is operably linked to a first linker polypeptide and the second antigen-binding polypeptide construct is operably linked to a second linker polypeptide, wherein the first and second linker polypeptides are covalently linked with each other, and wherein the linker polypeptides are operatively linked to a human IgG1 Fc region, wherein the first antigen-binding polypeptide construct is a Fab, wherein the Fab-linker-IgG1 Fc comprises a heavy chain comprising SEQ ID NO:97 and a light chain comprising SEQ ID NO:69, and wherein the second antigen-binding polypeptide construct is an scFv, wherein the scFv-linker-IgG1 Fc comprises SEQ ID NO:295, and wherein the human subject is administered at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 doses of the antigen binding construct, and/or wherein each dose is administered at least every 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 days.
A coated tablet comprising: (a) a tablet core wherein the tablet core comprises (i) optionally at least one antidiabetic agent or a pharmaceutically acceptable salt thereof selected from the group consisting of glyburide, metformin, rosiglitazone, pioglitazone, sitagliptin, vildagliptin, dapagliflozin, and dapagliflozin (S) propylene glycol hydrate; (b) an active coating layer surrounding the tablet core wherein the coating layer comprises, in admixture, (i) a coating material comprising poly(ethylene glycol) and poly(vinyl alcohol); (ii) an amine compound that is glycine, histidine, arginine, ethanolamine, diethanolamine or triethanolamine, or a combination thereof; and (iii) saxagliptin or a pharmaceutically acceptable salt thereof. (a) a tablet core wherein the tablet core comprises (i) optionally at least one antidiabetic agent or a pharmaceutically acceptable salt thereof selected from the group consisting of glyburide, metformin, rosiglitazone, pioglitazone, sitagliptin, vildagliptin, dapagliflozin, and dapagliflozin (S) propylene glycol hydrate; (i) optionally at least one antidiabetic agent or a pharmaceutically acceptable salt thereof selected from the group consisting of glyburide, metformin, rosiglitazone, pioglitazone, sitagliptin, vildagliptin, dapagliflozin, and dapagliflozin (S) propylene glycol hydrate; (b) an active coating layer surrounding the tablet core wherein the coating layer comprises, in admixture, (i) a coating material comprising poly(ethylene glycol) and poly(vinyl alcohol); (ii) an amine compound that is glycine, histidine, arginine, ethanolamine, diethanolamine or triethanolamine, or a combination thereof; and (iii) saxagliptin or a pharmaceutically acceptable salt thereof. (i) a coating material comprising poly(ethylene glycol) and poly(vinyl alcohol); (ii) an amine compound that is glycine, histidine, arginine, ethanolamine, diethanolamine or triethanolamine, or a combination thereof; and (iii) saxagliptin or a pharmaceutically acceptable salt thereof.
An in vitro or ex vivo method for obtaining induced smooth muscle cells (iSMCs), the method comprising the steps of: (a) isolating skeletal muscle derived cells from skeletal muscle tissue obtained from a subject; (b) transdifferentiating skeletal muscle derived cells by cultivating the cells in a medium containing TGF-beta, in particular TGFb1, TGFb2 and/or TGFb3, more preferably TGFb1 and/or TGFb3, most preferably TGFb1, and heparin to obtain iSMCs, wherein the skeletal muscle derived cells are myogenic progenitor cells (MPCs) characterized by the positive expression of CD56 and desmin, and the negative expression of CD34; or wherein the skeletal muscle derived cells are mesenchymal stromal cells (MSCs) characterized by the positive expression of CD105, CD73, and the negative expression of CD34 and CD56. (a) isolating skeletal muscle derived cells from skeletal muscle tissue obtained from a subject; (b) transdifferentiating skeletal muscle derived cells by cultivating the cells in a medium containing TGF-beta, in particular TGFb1, TGFb2 and/or TGFb3, more preferably TGFb1 and/or TGFb3, most preferably TGFb1, and heparin to obtain iSMCs, wherein the skeletal muscle derived cells are myogenic progenitor cells (MPCs) characterized by the positive expression of CD56 and desmin, and the negative expression of CD34; or wherein the skeletal muscle derived cells are mesenchymal stromal cells (MSCs) characterized by the positive expression of CD105, CD73, and the negative expression of CD34 and CD56.
A pharmaceutical composition comprising (a) a triblock copolymer having the formula: PLA v -PEG w -PLA x wherein v and x are the number of repeat units ranging from 1 to 3,000 and w is the number of repeat units ranging from 3 to 300 and v=x or v≠x in an amount of 22 to 34 w/w % of the total composition; (b) a diblock copolymer having the formula: mPEG y -PLA z wherein y and z are the number of repeat units with y ranging from 2 to 250 and z ranging from 1 to 3,000 in an amount of 5 to 9 w/w% of the total composition; (c) tacrolimus or a pharmaceutically acceptable salt, hydrate or solvate thereof, optionally tacrolimus monohydrate, in an amount of 8 to 32 w/w % of the total composition; and (d) organic solvent in an amount of 30 to 62 w/w % of the total composition; wherein the pharmaceutical composition is suitable for forming a depot when injected into the body. (a) a triblock copolymer having the formula: PLA v -PEG w -PLA x wherein v and x are the number of repeat units ranging from 1 to 3,000 and w is the number of repeat units ranging from 3 to 300 and v=x or v≠x in an amount of 22 to 34 w/w % of the total composition; (b) a diblock copolymer having the formula: mPEG y -PLA z wherein y and z are the number of repeat units with y ranging from 2 to 250 and z ranging from 1 to 3,000 in an amount of 5 to 9 w/w% of the total composition; (c) tacrolimus or a pharmaceutically acceptable salt, hydrate or solvate thereof, optionally tacrolimus monohydrate, in an amount of 8 to 32 w/w % of the total composition; and (d) organic solvent in an amount of 30 to 62 w/w % of the total composition;
Switch (100; 200; 300; 400; 500; 600) comprising: - first, second and third electrodes (107a, 107b, 107d; 607a, 607b, 107d); - a region made of a phase-change material coupling the first, second, and third electrodes; and - first, second, and third heater elements connected between a first surface of the region of phase-change material and the first, second, and third electrodes, respectively; and - a continuous conductive layer integrally coating a second surface of the region of phase-change material opposite to the first surface, the second and third heater elements being intended to modify the state of the phase-change material in first and second areas within said region by application respectively of a first control signal between the conductive layer and the second heater element, and of a second control signal between the conductive layer and the third heater element, wherein the first and second electrodes (107a, 107b; 607a, 607b) are intended to be connected to a radio frequency communication circuit and the third electrode is intended to be taken to a reference potential. - first, second and third electrodes (107a, 107b, 107d; 607a, 607b, 107d); - a region made of a phase-change material coupling the first, second, and third electrodes; and - first, second, and third heater elements connected between a first surface of the region of phase-change material and the first, second, and third electrodes, respectively; and - a continuous conductive layer integrally coating a second surface of the region of phase-change material opposite to the first surface, the second and third heater elements being intended to modify the state of the phase-change material in first and second areas within said region by application respectively of a first control signal between the conductive layer and the second heater element, and of a second control signal between the conductive layer and the third heater element, wherein the first and second electrodes (107a, 107b; 607a, 607b) are intended to be connected to a radio frequency communication circuit and the third electrode is intended to be taken to a reference potential.
An electronic device comprising: a printed circuit board, PCB, including a first surface , a second surface , and a side surface ; an electronic component (P) arranged on the first surface , adjacent to a portion of the side surface ; a shield structure (S) including a cap (s1) that covers the electronic component (P) and a sidewall (s2) extending from a periphery of the cap (s1) toward the first surface of the PCB, wherein the sidewall (s2) extends in a first direction that is non-parallel to the first surface of the PCB, and wherein the shield structure (S) is electrically connected to an exterior housing of the electronic device using an electric conducting portion; a first conductive structure that is formed on a portion of the side surface of the PCB; and a second conductive structure that is formed on a portion of the first surface to be connected to the first conductive structure, wherein the sidewall (s2) contacts with the first surface of the PCB and overlaps with the second conductive structure, when viewed from above the first surface of the PCB. a printed circuit board, PCB, including a first surface , a second surface , and a side surface ; an electronic component (P) arranged on the first surface , adjacent to a portion of the side surface ; a shield structure (S) including a cap (s1) that covers the electronic component (P) and a sidewall (s2) extending from a periphery of the cap (s1) toward the first surface of the PCB, wherein the sidewall (s2) extends in a first direction that is non-parallel to the first surface of the PCB, and wherein the shield structure (S) is electrically connected to an exterior housing of the electronic device using an electric conducting portion; a first conductive structure that is formed on a portion of the side surface of the PCB; and a second conductive structure that is formed on a portion of the first surface to be connected to the first conductive structure, wherein the sidewall (s2) contacts with the first surface of the PCB and overlaps with the second conductive structure, when viewed from above the first surface of the PCB.
A power semiconductor module arrangement comprising: two or more individual semiconductor devices , each semiconductor device comprising a lead frame , a semiconductor body that is arranged on the lead frame , and a molding material enclosing the semiconductor body and at least part of the lead frame ; a frame surrounding the two or more semiconductor devices ; and a casting compound at least partly filling a capacity within the frame , thereby at least partly enclosing the two or more individual semiconductor devices , wherein the leadframe protrudes from the casting compound and is configured to be mechanically and electrically connected to a printed circuit board , a contact collector device or to an electronic board ; each lead frame comprises a first leg and a second leg; the semiconductor body of each semiconductor device is arranged on the first leg of the respective lead frame ; the second leg of the individual lead frames are essentially perpendicular to the respective first leg, the second legs of the individual lead frames protrude from the casting compound , the first legs of the individual lead frames each form a bottom side of the respective semiconductor device ; and the first legs of the individual lead frames are arranged in the same plane. two or more individual semiconductor devices , each semiconductor device comprising a lead frame , a semiconductor body that is arranged on the lead frame , and a molding material enclosing the semiconductor body and at least part of the lead frame ; a frame surrounding the two or more semiconductor devices ; and a casting compound at least partly filling a capacity within the frame , thereby at least partly enclosing the two or more individual semiconductor devices , wherein the leadframe protrudes from the casting compound and is configured to be mechanically and electrically connected to a printed circuit board , a contact collector device or to an electronic board ; each lead frame comprises a first leg and a second leg; the semiconductor body of each semiconductor device is arranged on the first leg of the respective lead frame ; the second leg of the individual lead frames are essentially perpendicular to the respective first leg, the second legs of the individual lead frames protrude from the casting compound , the first legs of the individual lead frames each form a bottom side of the respective semiconductor device ; and the first legs of the individual lead frames are arranged in the same plane.
A leakage-flux flaw detection device that detects a linear defect of a steel strip, comprising: a plurality of leakage-flux flaw detection units provided at positions not in contact with the steel strip and arranged in a width direction of the steel strip, wherein the leakage-flux flaw detection units each include a rotating disk that faces a surface subjected to flaw detection of the steel strip and that rotates, and a plurality of defect detection heads that are installed at different positions in a circumferential direction on the rotating disk, that perform direct-current magnetization of the steel strip, and that detect leakage flux leaking from a linear defect due to the direct-current magnetization, and characterised in that at least one of the plurality of defect detection heads has an inclination angle different from inclination angles of the other defect detection heads, the inclination angle being defined by a tangent line of a rotation trajectory and the magnetization direction at an installation position of the defect detection head. a plurality of leakage-flux flaw detection units provided at positions not in contact with the steel strip and arranged in a width direction of the steel strip, wherein the leakage-flux flaw detection units each include a rotating disk that faces a surface subjected to flaw detection of the steel strip and that rotates, and a plurality of defect detection heads that are installed at different positions in a circumferential direction on the rotating disk, that perform direct-current magnetization of the steel strip, and that detect leakage flux leaking from a linear defect due to the direct-current magnetization, and characterised in that at least one of the plurality of defect detection heads has an inclination angle different from inclination angles of the other defect detection heads, the inclination angle being defined by a tangent line of a rotation trajectory and the magnetization direction at an installation position of the defect detection head. a rotating disk that faces a surface subjected to flaw detection of the steel strip and that rotates, and a plurality of defect detection heads that are installed at different positions in a circumferential direction on the rotating disk, that perform direct-current magnetization of the steel strip, and that detect leakage flux leaking from a linear defect due to the direct-current magnetization, and characterised in that at least one of the plurality of defect detection heads has an inclination angle different from inclination angles of the other defect detection heads, the inclination angle being defined by a tangent line of a rotation trajectory and the magnetization direction at an installation position of the defect detection head.