mhurhangee/patent-ind-claim-en huggingface dataset:
An anti-CD47 antibody for use in a method of treating a platinum resistant human epithelial ovarian cancer, comprising a. administering a priming dose of the anti-CD47 antibody to the subject, wherein the priming dose is 1 mg/kg of the anti-CD47 antibody; and b. administering a therapeutically effective dose of the anti-CD47 antibody to the subject, wherein the therapeutically effective dose of the anti-CD47 antibody is 20 to 60 mg/kg, and wherein step (b) is performed after at least about 7 days after beginning step (a) and every 7 days thereafter; and c. administering Avelumab to the subject, wherein the dose of Avelumab is 10 mg/kg, and wherein step (c) is performed at least about 7 days after step (a) and every 14 days thereafter, wherein the anti-CD47 antibody has the heavy chain and light chain sequences of SEQ ID NOs: 1 and 2, respectively. a. administering a priming dose of the anti-CD47 antibody to the subject, wherein the priming dose is 1 mg/kg of the anti-CD47 antibody; and b. administering a therapeutically effective dose of the anti-CD47 antibody to the subject, wherein the therapeutically effective dose of the anti-CD47 antibody is 20 to 60 mg/kg, and wherein step (b) is performed after at least about 7 days after beginning step (a) and every 7 days thereafter; and c. administering Avelumab to the subject, wherein the dose of Avelumab is 10 mg/kg, and wherein step (c) is performed at least about 7 days after step (a) and every 14 days thereafter, wherein the anti-CD47 antibody has the heavy chain and light chain sequences of SEQ ID NOs: 1 and 2, respectively.
Bicycle mudguard comprising a rod and a fastening device in order to fasten the rod to a bicycle component , wherein the fastening device comprises, - a clamping device comprising a body in which a clamping passage is provided, wherein the rod extends through the clamping passage along a clamping surface which is formed by a wall surface that delimits the clamping passage , and at least one clamping element , which is movable and/or deformable transversely to the longitudinal axis (E) of the rod in order to be brought from a non-clamping position into a clamping position, wherein the clamping element brought into the clamping position pushes the rod against the clamping surface , so that the rod is detained in a fixed position in the clamping device , and - an elongated fastening means in order to fasten the clamping device to a bicycle component , wherein the clamping device and the fastening means are provided to realize the fastening by moving the fastening means according to the longitudinal direction (L) of the rod with respect to the clamping device , and wherein the clamping device comprises transmission means in order to transmit to the clamping element the motion of the fastening means in such a way during this movement that this clamping element is moved and/or deformed transversely to the longitudinal direction (L) until it reaches the clamping position, characterized in that in the clamping element is provided a first clamping passage , and the clamping passage in the body is a second clamping passage , in that the clamping element and the body are provided such that the first and the second clamping passage lie in alignment, in that the rod extends through the first and the second clamping passage , in that the body comprises at least one guide surface , in that the clamping element comprises at least one contact surface , which, during the movement of the fastening means , is moved over a guide surface of the body , so that the clamping element is moved according to the transverse direction (D) until it has reached the clamping position. - a clamping device comprising a body in which a clamping passage is provided, wherein the rod extends through the clamping passage along a clamping surface which is formed by a wall surface that delimits the clamping passage , and at least one clamping element , which is movable and/or deformable transversely to the longitudinal axis (E) of the rod in order to be brought from a non-clamping position into a clamping position, wherein the clamping element brought into the clamping position pushes the rod against the clamping surface , so that the rod is detained in a fixed position in the clamping device , and - an elongated fastening means in order to fasten the clamping device to a bicycle component ,
A cold-rolled low-density steel sheet having excellent phosphorability, wherein: an iron particle layer is disposed on a surface of the cold-rolled low-density steel sheet, and dispersed iron particles exist in the iron particle layer; at the inner side of the iron particle layer is an internal oxidized layer which is adjacent to the iron particle layer, and the internal oxidized layer contains oxides of Al; the iron particles have a particle size of 0.1∼5 μm, and the iron particles cover 30% or more of the surface area of the steel sheet; the cold-rolled low-density steel sheet contains 3.0% to 7.0% of element Al by mass percentage. an iron particle layer is disposed on a surface of the cold-rolled low-density steel sheet, and dispersed iron particles exist in the iron particle layer; at the inner side of the iron particle layer is an internal oxidized layer which is adjacent to the iron particle layer, and the internal oxidized layer contains oxides of Al; the iron particles have a particle size of 0.1∼5 μm, and the iron particles cover 30% or more of the surface area of the steel sheet; the cold-rolled low-density steel sheet contains 3.0% to 7.0% of element Al by mass percentage.
A method of localising a wireless access point (B1, B2, B3) to a communication network, comprising the steps of: - reconstructing a trajectory (T) followed by a mobile device during a displacement during which the mobile device makes successive measurements of an indicator related to the distance separating the mobile device from the access point; - determining a localisation (T1, T2, T3) on the trajectory at which each of said measurements is made; - selecting (E3, E4) and evaluating (E6, E7) a possible localisation (Lp, Lp1, Lp2, Lp3) of the access point, said evaluating including: ∘ using all or some of the measurements and the distances separating the possible localisation of the access point from each of the localisations at which a measurement is made, determining parameters of a propagation model relating said indicator and the distance; ∘ calculating, for each measurement among all of some of said measurements, of a difference between the distance separating the possible localisation of the access point and the localisation at which the measurement is made, and a distance estimated using the measurement and the propagation model; and ∘ calculating a localisation error from the calculated differences. - reconstructing a trajectory (T) followed by a mobile device during a displacement during which the mobile device makes successive measurements of an indicator related to the distance separating the mobile device from the access point; - determining a localisation (T1, T2, T3) on the trajectory at which each of said measurements is made; - selecting (E3, E4) and evaluating (E6, E7) a possible localisation (Lp, Lp1, Lp2, Lp3) of the access point, said evaluating including: ∘ using all or some of the measurements and the distances separating the possible localisation of the access point from each of the localisations at which a measurement is made, determining parameters of a propagation model relating said indicator and the distance; ∘ calculating, for each measurement among all of some of said measurements, of a difference between the distance separating the possible localisation of the access point and the localisation at which the measurement is made, and a distance estimated using the measurement and the propagation model; and ∘ calculating a localisation error from the calculated differences. ∘ using all or some of the measurements and the distances separating the possible localisation of the access point from each of the localisations at which a measurement is made, determining parameters of a propagation model relating said indicator and the distance; ∘ calculating, for each measurement among all of some of said measurements, of a difference between the distance separating the possible localisation of the access point and the localisation at which the measurement is made, and a distance estimated using the measurement and the propagation model; and ∘ calculating a localisation error from the calculated differences.
An image post-processing method for controlling a glossiness of a fixed toner image , the method comprising a glossiness control step of: irradiating the fixed toner image formed with a toner containing a compound that absorbs light and fixed on a recording medium with a glossiness control light that is capable of reducing a glossiness of the fixed toner image , wherein the glossiness control light has a maximum emission wavelength in a wavelength region which is absorbed by the compound, and wherein a light amount of the glossiness control light in the glossiness control step is controlled based on glossiness information designated by a user, characterized in that the light amount of the glossiness control light is controlled based on relational information on a change in the glossiness of the toner image with respect to the light amount of the glossiness control light to be irradiated. irradiating the fixed toner image formed with a toner containing a compound that absorbs light and fixed on a recording medium with a glossiness control light that is capable of reducing a glossiness of the fixed toner image , wherein the glossiness control light has a maximum emission wavelength in a wavelength region which is absorbed by the compound, and wherein a light amount of the glossiness control light in the glossiness control step is controlled based on glossiness information designated by a user, characterized in that the light amount of the glossiness control light is controlled based on relational information on a change in the glossiness of the toner image with respect to the light amount of the glossiness control light to be irradiated.
A method for service load distribution in a data network , the method comprising: generating , by a cluster master , a service policy for distributing service requests among a plurality of devices associated with the data network , wherein the plurality of devices includes a plurality of routers, a plurality of traffic distribution engines , and a plurality of service nodes ; providing , by the cluster master , the service policy to the plurality of devices associated with the data network ; receiving , by the plurality of routers, one or more service requests ; distributing, by the plurality of routers, the one or more service requests evenly to one or more of the plurality of traffic distribution engines ; distributing, by the one or more of the plurality of traffic distribution engines , the one or more service requests asymmetrically to one or more of the plurality of service nodes according to the service policy ; and forwarding, by the one or more of the plurality of service nodes , the one or more service requests to one or more backend servers according to the service policy; wherein the service policy is generated based on at least a responsiveness of each of the plurality of service nodes and reachability of the one or more backend servers to the one or more of the plurality of service nodes . generating , by a cluster master , a service policy for distributing service requests among a plurality of devices associated with the data network , wherein the plurality of devices includes a plurality of routers, a plurality of traffic distribution engines , and a plurality of service nodes ; providing , by the cluster master , the service policy to the plurality of devices associated with the data network ; receiving , by the plurality of routers, one or more service requests ; distributing, by the plurality of routers, the one or more service requests evenly to one or more of the plurality of traffic distribution engines ; distributing, by the one or more of the plurality of traffic distribution engines , the one or more service requests asymmetrically to one or more of the plurality of service nodes according to the service policy ; and forwarding, by the one or more of the plurality of service nodes , the one or more service requests to one or more backend servers according to the service policy; wherein the service policy is generated based on at least a responsiveness of each of the plurality of service nodes and reachability of the one or more backend servers to the one or more of the plurality of service nodes .
A system, comprising: a first optical assembly, OA , which is coupled with a first eyepiece of a stereoscopic microscope, SM, , the first OA comprising: (i) a first light source , configured to direct a first emitted light beam, ELB, through the SM toward an organ of a patient, and (ii) a first image sensor , configured to sense a first reflected light beam, RLB , which is reflected from the organ through the SM , and to produce a first signal indicative of the first RLB ; a second OA , which is coupled with a second eyepiece of the SM , the second OA comprising: (i) a second light source , configured to direct a second ELB through the SM toward the organ, and (ii) a second image sensor , configured to sense a second RLB , which is reflected from the organ through the SM, and to produce a second signal indicative of the second RLB ; and a processor, which is configured to: control the first and second OAs to alternately: (i) direct the first ELB and sense the first RLB at first time intervals, and (ii) direct the second ELB and sense the second RLB at second different time intervals; and alternately: (i) display on a first display , during the first time intervals, first images based on the first signal, and (ii) display on a second display , during the second time intervals, second images based on the second signal. a first optical assembly, OA , which is coupled with a first eyepiece of a stereoscopic microscope, SM, , the first OA comprising: (i) a first light source , configured to direct a first emitted light beam, ELB, through the SM toward an organ of a patient, and (ii) a first image sensor , configured to sense a first reflected light beam, RLB , which is reflected from the organ through the SM , and to produce a first signal indicative of the first RLB ; a second OA , which is coupled with a second eyepiece of the SM , the second OA comprising: (i) a second light source , configured to direct a second ELB through the SM toward the organ, and (ii) a second image sensor , configured to sense a second RLB , which is reflected from the organ through the SM, and to produce a second signal indicative of the second RLB ; and a processor, which is configured to: control the first and second OAs to alternately: (i) direct the first ELB and sense the first RLB at first time intervals, and (ii) direct the second ELB and sense the second RLB at second different time intervals; and alternately: (i) display on a first display , during the first time intervals, first images based on the first signal, and (ii) display on a second display , during the second time intervals, second images based on the second signal. control the first and second OAs to alternately: (i) direct the first ELB and sense the first RLB at first time intervals, and (ii) direct the second ELB and sense the second RLB at second different time intervals; and alternately: (i) display on a first display , during the first time intervals, first images based on the first signal, and (ii) display on a second display , during the second time intervals, second images based on the second signal.
A method comprising: mixing a foaming agent in a liquid medium; receiving , via a first window , incident light on a solution , wherein the solution comprises the liquid medium, a gas dissolved in the liquid medium, and a plurality of nanostructures in contact with the liquid medium; generating heat in the liquid medium based on oscillations of a subset of the plurality of nanostructures in response to the incident light; releasing at least a portion of the gas from the solution as gas bubbles in response to the generated heat; and scattering , by the released gas bubbles, the incident light to prevent the incident light from reaching a second window . mixing a foaming agent in a liquid medium; receiving , via a first window , incident light on a solution , wherein the solution comprises the liquid medium, a gas dissolved in the liquid medium, and a plurality of nanostructures in contact with the liquid medium; generating heat in the liquid medium based on oscillations of a subset of the plurality of nanostructures in response to the incident light; releasing at least a portion of the gas from the solution as gas bubbles in response to the generated heat; and scattering , by the released gas bubbles, the incident light to prevent the incident light from reaching a second window .
A therapeutically active fragment of the angiopoietin like 4 protein (ANGPTL4) for use in increasing wound healing in a diabetic individual in need thereof, comprising the C-terminal region of ANGPTL4 or a functional fragment thereof, wherein the therapeutically active fragment of ANGPTL4 comprises the amino acid sequence set forth in SEQ ID NO:2.
A composition comprising a β-cyclodextrin and a pharmaceutical agent, wherein the pharmaceutical agent is a 3-halopyruvate, wherein at least one α-D-glucopyranoside unit of the cyclodextrin has at least one hydroxyl chemical group replaced with an ionizable chemical group resulting in a negative charge and wherein the cyclodextrin encapsulates the pharmaceutical agent.
A device , comprising: a central tube , a plurality of tube chambers disposed around the central tube, each comprising a rod element configured to rotate about its own axis disposed therein, each rod element comprising a curved and unattached free end portion comprising a leading sharpened edge, the end portion being biased against an internal surface within the tube chamber to assume a first radius of curvature; wherein each rod element is configured for deployment from its respective tube chamber , the curved and unattached free end portion of each rod element being configured to assume a second radius of curvature when deployed outside of its respective tube chamber, the second radius of curvature being smaller than the first radius of curvature and wherein the curved and unattached free end portions of the deployed rod elements are configured to collectively circumscribe, cut and part off a volume of tissue as each rod element is rotated about its own axis and as the device is rotated. a central tube , a plurality of tube chambers disposed around the central tube, each comprising a rod element configured to rotate about its own axis disposed therein, each rod element comprising a curved and unattached free end portion comprising a leading sharpened edge, the end portion being biased against an internal surface within the tube chamber to assume a first radius of curvature; wherein each rod element is configured for deployment from its respective tube chamber , the curved and unattached free end portion of each rod element being configured to assume a second radius of curvature when deployed outside of its respective tube chamber, the second radius of curvature being smaller than the first radius of curvature and wherein the curved and unattached free end portions of the deployed rod elements are configured to collectively circumscribe, cut and part off a volume of tissue as each rod element is rotated about its own axis and as the device is rotated.
A powershift transmission for a drivetrain , which has an electric motor , of a motor vehicle, in particular of a utility vehicle, having: at most two planetary transmission stages which are arranged in series and which have a first planetary transmission stage and a second planetary transmission stage , wherein a sun gear of the first planetary transmission stage forms a transmission input element of the powershift transmission , which transmission input element is connectable to the electric motor , and wherein a planet carrier of the second planetary transmission stage forms a transmission output element of the powershift transmission , which transmission output element is connectable to an axle transmission of the drivetrain ; a first powershift element which is arranged for the selective connection of the first planetary transmission stage and the second planetary transmission stage via a first drive path (A); a second powershift element which is arranged for the selective fixing of a component of the first planetary transmission stage to a housing of the powershift transmission ; and a switchover element which is arranged for the selective connection of the first planetary transmission stage and of the second planetary transmission stage via a second drive path (B) or a third drive path (C). at most two planetary transmission stages which are arranged in series and which have a first planetary transmission stage and a second planetary transmission stage , wherein a sun gear of the first planetary transmission stage forms a transmission input element of the powershift transmission , which transmission input element is connectable to the electric motor , and wherein a planet carrier of the second planetary transmission stage forms a transmission output element of the powershift transmission , which transmission output element is connectable to an axle transmission of the drivetrain ; a first powershift element which is arranged for the selective connection of the first planetary transmission stage and the second planetary transmission stage via a first drive path (A); a second powershift element which is arranged for the selective fixing of a component of the first planetary transmission stage to a housing of the powershift transmission ; and a switchover element which is arranged for the selective connection of the first planetary transmission stage and of the second planetary transmission stage via a second drive path (B) or a third drive path (C).
A method for sorting phonebook contacts by a communication device, the method comprising: identifying at least one contact incentive for each application in the communication device , wherein the at least one contact incentive indicates a reference of each phonebook contact in each application; calculating a weight of each phonebook contact for each application using the identified at least one contact incentive (403; 405); identifying at least one application incentive based on a number of times a phonebook function is accessed from each application in the communication device ; calculating a weight of each application based on the identified at least one application incentive (703; 705); sorting the phonebook contacts based on weights of the phonebook contacts and weights of the applications ; and displaying the sorted phonebook contacts in a display of the communication device. identifying at least one contact incentive for each application in the communication device , wherein the at least one contact incentive indicates a reference of each phonebook contact in each application; calculating a weight of each phonebook contact for each application using the identified at least one contact incentive (403; 405); identifying at least one application incentive based on a number of times a phonebook function is accessed from each application in the communication device ; calculating a weight of each application based on the identified at least one application incentive (703; 705); sorting the phonebook contacts based on weights of the phonebook contacts and weights of the applications ; and displaying the sorted phonebook contacts in a display of the communication device.