mhurhangee/patent-ind-claim-en huggingface dataset:
A method of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent, the method comprising: (a) contacting the potential toxic agent with a three-dimensional, engineered, bioprinted, biological renal tubule model comprising: (i) a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and (ii) a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, to form the three-dimensional, engineered, biological renal tubule model; provided that the interstitial tissue comprises an interstitial bio-ink comprising renal fibroblasts and endothelial cells, and the epithelial tissue comprises an epithelial bio-ink comprising renal tubular epithelial cells; (b) contacting the renal tubule model with the candidate therapeutic agent; (c) determining the viability or functionality of the renal tubular epithelial cells; and (d) assessing the ability of the candidate therapeutic agent to reverse, reduce or prevent renal injury by the potential toxic agent based on the determined viability or functionality of the renal tubular epithelial cells compared to a control renal tubule model that has not been contacted with the candidate therapeutic agent. (a) contacting the potential toxic agent with a three-dimensional, engineered, bioprinted, biological renal tubule model comprising: (i) a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and (ii) a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, to form the three-dimensional, engineered, biological renal tubule model; provided that the interstitial tissue comprises an interstitial bio-ink comprising renal fibroblasts and endothelial cells, and the epithelial tissue comprises an epithelial bio-ink comprising renal tubular epithelial cells; (i) a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and (ii) a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, to form the three-dimensional, engineered, biological renal tubule model; (b) contacting the renal tubule model with the candidate therapeutic agent; (c) determining the viability or functionality of the renal tubular epithelial cells; and (d) assessing the ability of the candidate therapeutic agent to reverse, reduce or prevent renal injury by the potential toxic agent based on the determined viability or functionality of the renal tubular epithelial cells compared to a control renal tubule model that has not been contacted with the candidate therapeutic agent.
A silencer comprising: a hollow tubular portion in which a discharge flow passage is formed that communicates, on one end side of the tubular portion , with a discharge port of a fluid pressure device through which a pressure fluid is discharged; a cap member attached to another end part of the hollow tubular portion ; a sound absorbing member attached to an inner wall surface of the hollow tubular portion ; and a plurality of discharge ports (64a to 64d) adapted to discharge the pressure fluid, which has passed through the discharge flow passage in an axial direction of the hollow tubular portion , in radial directions perpendicular to the axial direction, wherein the cap member includes the plurality of the discharge ports (64a to 64d), characterized in that the cap member further includes a disk-shaped distal end part , prism-shaped parts that support the distal end part and are spaced equidistantly from each other in a circumferential direction, an annular connecting part that supports the prism-shaped parts and is fitted into the hollow tubular portion , and that the discharge ports (64a to 64d) are formed between the prism-shaped parts . a hollow tubular portion in which a discharge flow passage is formed that communicates, on one end side of the tubular portion , with a discharge port of a fluid pressure device through which a pressure fluid is discharged; a cap member attached to another end part of the hollow tubular portion ; a sound absorbing member attached to an inner wall surface of the hollow tubular portion ; and a plurality of discharge ports (64a to 64d) adapted to discharge the pressure fluid, which has passed through the discharge flow passage in an axial direction of the hollow tubular portion , in radial directions perpendicular to the axial direction, wherein the cap member includes the plurality of the discharge ports (64a to 64d), characterized in that the cap member further includes a disk-shaped distal end part , prism-shaped parts that support the distal end part and are spaced equidistantly from each other in a circumferential direction, an annular connecting part that supports the prism-shaped parts and is fitted into the hollow tubular portion , and that the discharge ports (64a to 64d) are formed between the prism-shaped parts . a disk-shaped distal end part , prism-shaped parts that support the distal end part and are spaced equidistantly from each other in a circumferential direction, an annular connecting part that supports the prism-shaped parts and is fitted into the hollow tubular portion , and that the discharge ports (64a to 64d) are formed between the prism-shaped parts .
A fastening system for an electrical stimulation generator , comprising a generator for cardiac stimulation, such as a pacemaker, a defibrillator, a resynchronizer; a neurostimulation mechanism or another similar generator disposed externally with respect to the body of the patient and an electrode that presents a first end (5.1) for connection to the heart of the patient and a second end (5.2) for connection to said generator , characterized in that it further comprises: - a casing for containing the generator therein that presents identical first and second openings (7.1, 7.2) disposed on opposite sides thereof; - means for the connection of the electrode to the first or second opening (7.1, 7.2) in the casing formed by a first pass-through connector for the second end (5.2) of the electrode , wherein the first connector has an airtight valve therein; - an airtight closing element disposed at the opening of the casing opposite the one presenting the means for the connection of the electrode ; - a device for securing the electrode to the skin having means for anchoring to said electrode and means for adhering to the torso of the patient ; and - means for fastening the casing to the body of the patient . wherein the casing is formed by a rear part (8.1) in contact with the body of the patient and a front part (8.2), joined together by hinged means and comprises closing means at an end opposite the hinged means by means of the fitting of the first connector and of the closing element in both first and second openings (7.1, 7.2) of the casing , each one in one of said openings; wherein the positions of the closing element and the first connector are interchangeable allowing the electrode to be connectable to the first opening (7.1) or to the second opening (7.2). - a casing for containing the generator therein that presents identical first and second openings (7.1, 7.2) disposed on opposite sides thereof; - means for the connection of the electrode to the first or second opening (7.1, 7.2) in the casing formed by a first pass-through connector for the second end (5.2) of the electrode , wherein the first connector has an airtight valve therein; - an airtight closing element disposed at the opening of the casing opposite the one presenting the means for the connection of the electrode ; - a device for securing the electrode to the skin having means for anchoring to said electrode and means for adhering to the torso of the patient ; and - means for fastening the casing to the body of the patient .
A method comprising: producing an optical bonding apparatus (30; 40) with at least a pressure sensitive bonding layer (310; 410) and a thermal flow pressure sensitive bonding layer (320; 420) bonded together; and placing the optical bonding apparatus (30; 40) between a touch panel and an LCD panel , wherein the material of the thermal flow pressure sensitive bonding layer (320; 420) is a thermal flow type; wherein the detailed processes comprise: laminating the thermal flow pressure sensitive bonding layer (320; 420) on the rough surface of the touch panel; laminating the pressure sensitive bonding layer on the thermal flow pressure sensitive bonding layer; and laminating the LCD panel on the pressure sensitive bonding layer; wherein the method further comprises a process of auto-claving after each process of laminating. producing an optical bonding apparatus (30; 40) with at least a pressure sensitive bonding layer (310; 410) and a thermal flow pressure sensitive bonding layer (320; 420) bonded together; and placing the optical bonding apparatus (30; 40) between a touch panel and an LCD panel , wherein the material of the thermal flow pressure sensitive bonding layer (320; 420) is a thermal flow type; wherein the detailed processes comprise: laminating the thermal flow pressure sensitive bonding layer (320; 420) on the rough surface of the touch panel; laminating the pressure sensitive bonding layer on the thermal flow pressure sensitive bonding layer; and laminating the LCD panel on the pressure sensitive bonding layer; wherein the method further comprises a process of auto-claving after each process of laminating. laminating the thermal flow pressure sensitive bonding layer (320; 420) on the rough surface of the touch panel; laminating the pressure sensitive bonding layer on the thermal flow pressure sensitive bonding layer; and laminating the LCD panel on the pressure sensitive bonding layer; wherein the method further comprises a process of auto-claving after each process of laminating.
A method of molding a single-phase polymer and gas solution, the method comprising: mixing a polymer composition above a glass transition temperature of the polymer composition with a gas above atmospheric pressure to form the single-phase solution; pressurizing a first mold cavity of a mold above atmospheric pressure to a mold pressure, wherein the mold pressure is at least a pressure to maintain the single-phase solution as a homogeneous solution; while maintaining the first mold cavity at least at the mold pressure, injecting the single-phase solution into the first mold cavity; and depressurizing the first mold cavity below the molding pressure, characterized in that the method comprises: cooling the single-phase solution below the glass transition temperature to form a single-phase, solid article in the first mold cavity.
A vehicle air-conditioning control method comprising: - calculating an air-conditioning reference temperature for an interior of a vehicle on the basis of an in-vehicle temperature measured by an in-vehicle temperature sensor provided inside the vehicle that runs between stations , an outside air temperature measured by an outside air temperature sensor provided on the exterior of the vehicle , an in-vehicle humidity measured by a humidity sensor provided inside the vehicle , and a vehicle occupancy rate measured by a vehicle occupancy rate sensor to provide a vehicle occupancy rate signal, the sensor provided in the vehicle ; - determining an air-conditioning control pattern for performing air-conditioning of the inside of the vehicle on the basis of the air-conditioning reference temperature; and - controlling a vehicle air-conditioning apparatus on the basis of the air-conditioning control pattern, characterized in that the data of a preceding vehicle is received, and is used in air-conditioning control of the following vehicle . - calculating an air-conditioning reference temperature for an interior of a vehicle on the basis of an in-vehicle temperature measured by an in-vehicle temperature sensor provided inside the vehicle that runs between stations , an outside air temperature measured by an outside air temperature sensor provided on the exterior of the vehicle , an in-vehicle humidity measured by a humidity sensor provided inside the vehicle , and a vehicle occupancy rate measured by a vehicle occupancy rate sensor to provide a vehicle occupancy rate signal, the sensor provided in the vehicle ; - determining an air-conditioning control pattern for performing air-conditioning of the inside of the vehicle on the basis of the air-conditioning reference temperature; and - controlling a vehicle air-conditioning apparatus on the basis of the air-conditioning control pattern,
A vertical takeoff and landing unmanned aerial vehicle, comprising: a left main wing and a right main wing ; a left front wing and a right front wing ; a main body which is engaged with the left main wing and the right main wing ; a left linear support for connecting the left main wing with the left front wing ; a right linear support for connecting the right main wing with the right front wing ; the left linear support having a first group of multiple lift propellers arranged thereon; the right linear support having a second group of multiple lift propellers arranged thereon; wherein the left linear support and the right linear support each have a hollow interior suitable to arrange equipment therein; and a forward-facing opening which is provided at the front end of each of the left linear support and the right linear support , wherein the opening is formed as a trumpet-shaped structure, wherein the radial sectional area of one end, toward the hollow interior, of the opening is less than that of one end, away from the hollow interior, of the opening . a left main wing and a right main wing ; a left front wing and a right front wing ; a main body which is engaged with the left main wing and the right main wing ; a left linear support for connecting the left main wing with the left front wing ; a right linear support for connecting the right main wing with the right front wing ; the left linear support having a first group of multiple lift propellers arranged thereon; the right linear support having a second group of multiple lift propellers arranged thereon; wherein the left linear support and the right linear support each have a hollow interior suitable to arrange equipment therein; and the left linear support having a first group of multiple lift propellers arranged thereon; the right linear support having a second group of multiple lift propellers arranged thereon; wherein the left linear support and the right linear support each have a hollow interior suitable to arrange equipment therein; and a forward-facing opening which is provided at the front end of each of the left linear support and the right linear support , wherein the opening is formed as a trumpet-shaped structure, wherein the radial sectional area of one end, toward the hollow interior, of the opening is less than that of one end, away from the hollow interior, of the opening .
Apparatus for evacuating a gas stream comprising a corrosive fluid exhausted from a processing chamber , comprising: a dry pumping arrangement for evacuating the gas stream comprising a corrosive fluid from the processing chamber; a liquid ring pump arranged for evacuating the gas stream comprising a corrosive fluid from the dry pump and at least partially reducing the corrosive fluid content of the gas stream by dissolving said corrosive fluid into the service liquid of the liquid ring pump; a separator for separating, from the service liquid and remaining gas stream mixture exhausted from the liquid ring pump, the remaining gas stream; and an abatement arrangement for treating the separated remaining gas stream exhausted from the separator and characterised in that the liquid ring pump comprises a drive shaft , connected for driving the rotor for pumping gas in a stator, said liquid ring pump being adapted to be installed in a vertical orientation with the drive shaft extending in a substantially vertical orientation; and a vertical gas inlet, configured to be parallel to the vertical axis of rotation and receive gas conveyed in a substantially downward direction so that any particulates in the exhaust gas stream are conveyed in the direction of gravity into the pump. a dry pumping arrangement for evacuating the gas stream comprising a corrosive fluid from the processing chamber; a liquid ring pump arranged for evacuating the gas stream comprising a corrosive fluid from the dry pump and at least partially reducing the corrosive fluid content of the gas stream by dissolving said corrosive fluid into the service liquid of the liquid ring pump; a separator for separating, from the service liquid and remaining gas stream mixture exhausted from the liquid ring pump, the remaining gas stream; and an abatement arrangement for treating the separated remaining gas stream exhausted from the separator and characterised in that the liquid ring pump comprises a drive shaft , connected for driving the rotor for pumping gas in a stator, said liquid ring pump being adapted to be installed in a vertical orientation with the drive shaft extending in a substantially vertical orientation; and a vertical gas inlet, configured to be parallel to the vertical axis of rotation and receive gas conveyed in a substantially downward direction so that any particulates in the exhaust gas stream are conveyed in the direction of gravity into the pump.
A grate comprising at least one structural element comprising at least a length of a reformed flat strip , which strip is folded successively along fold lines lying at an angle to a longitudinal axis of the unfolded strip , wherein at least three fold lines extend parallel to each other, wherein the reformed flat strip comprises at least three flat parts , each part being connected to an adjacent part at one of the fold lines , wherein at each fold line the parts are folded in the same direction, whereby the reformed flat strip forms a coil (75, 75', 75", 75′′′, 85, 86, 105, 105', 105", 105′′′) comprising a number of windings, wherein each winding comprises at least three flat parts , characterized in that the grate comprises at least two coils (75, 75', 75", 75′′′, 85, 86, 105, 105', 105", 105′′′), extending parallel to each other, wherein the coils (75, 75', 75", 75′′′, 85, 86, 105, 105', 105", 105′′′) are positioned against each other and connected to each other via flat parts of the coils (75, 75', 75", 75"', 85, 86, 105, 105', 105", 105′′′).
Ventilation unit having a housing which is made up of a modular frame system with a multiplicity of assembled frame elements and describes at least one three-dimensional rectangular main body (G), wherein at least the frame-formed outer surfaces are provided with walls, wherein the main body (G) is formed by frame profiles which are connected to one another at the ends, surround profiles are arranged on the outer sides of the frame profiles of each main body (G), walls are fitted in between the surround profiles at least on the outer sides of the ventilation unit, and the frame profiles have sealing means , which butt against the walls and seal the ventilation unit in the outward direction, characterized in that the cover profile is arranged on the at least one frame profile such that an accessible installation channel (I), which is located within the main body (G), forms along the at least one frame profile , wherein cables and/or pressure-measuring lines and/or supply lines are laid in the installation channel (I), and at least one cable or a pressure-measuring line or a supply line is directed outwards by way of a corner element.
A method for controlling a binaural hearing system with two hearing instruments each hearing instrument configured to provide a tinnitus relief sound, wherein each of the hearing instruments include a tinnitus relief sound generator, wherein each of the tinnitus relief sound generators are configured for generating a tinnitus relief sound of finite length, wherein the tinnitus relief sound generated in the two hearing instruments are identical and presented to the user as repeated in endless loops, the method comprising: a) providing a signal to be modulated, the signal being a noise signal, a pure tone signal or a signal comprising multiple tones, b) modulating the signal by a preprogrammed modulation scheme, thereby providing the tinnitus relief sound, d) generating an output signal based on the tinnitus relief sound, wherein in the binaural hearing system, the hearing instruments communicate via a communication link, the hearing instruments exchange information so that onset of the tinnitus relief sound in the two hearing instruments are offset by an offset time, e) wherein using the communication link between the hearing instruments, the tinnitus relief sounds are reset to their starting point regularly at the same point of time. a) providing a signal to be modulated, the signal being a noise signal, a pure tone signal or a signal comprising multiple tones, b) modulating the signal by a preprogrammed modulation scheme, thereby providing the tinnitus relief sound, d) generating an output signal based on the tinnitus relief sound, wherein in the binaural hearing system, the hearing instruments communicate via a communication link, the hearing instruments exchange information so that onset of the tinnitus relief sound in the two hearing instruments are offset by an offset time, e) wherein using the communication link between the hearing instruments, the tinnitus relief sounds are reset to their starting point regularly at the same point of time.
An intravenous infusion dosage form comprising: an aqueous solution of pemetrexed or its pharmaceutically acceptable salt at a concentration ranging from 1.0 mg/ml to 20.0 mg/ml present in a multilayered flexible plastic infusion container, characterised in that the multilayered flexible plastic infusion container has an oxygen scavenger layer sandwiched between an outermost and an innermost layer of the container, the container being free of a polyamide and wherein the multilayered flexible plastic infusion container filled with the aqueous solution of pemetrexed is autoclavable.