mhurhangee/patent-ind-claim-en huggingface dataset:
An in vitro or ex vivo method of genome editing in a human cell using a Cas9 DNA endonuclease to effect a double-strand break (DSB) at one or more loci within the β- globin region of human chromosome 11, causing deletions or insertions of chromosomal DNA at the one or more loci, wherein the method comprises introducing into the cell the Cas9 DNA endonuclease and one or more guide RNAs, wherein each guide RNA comprises a spacer sequence that is complementary to the one or more loci within the β- globin region of human chromosome 11, and wherein the one or more guide RNAs comprise a spacer sequence selected from a corresponding RNA sequence of SEQ ID NOs: 161, 203; 161, 204; 161, 205; 161, 206; 161, 207; 161, 213; 161, 215; 161, 216; 161, 217; 161, 218; 161, 220; 161, 221; 161, 222; 161, 224; 161, 230; 161, 231; 161, 309; 161, 233; 161, 235; 161, 236; 161, 237; 161, 240; 161, 241; 161, 243; 161, 245; 161, 250; 161, 252; 161, 254; 161, 255; 161, 256; 161, 257; 161, 258; 161, 259; 161, 262; 161, 265; 161, 267; 161, 269; 161, 271; 161, 272; 161, 273; 161, 274; 161, 275; 161, 278; 161, 279; 161, 280; 161, 281; 161, 283; 161, 287; 161, 297; 161, 298; 161, 299; 161, 300; 161, 303; 161,310; 161,311; and 161, 312, wherein the method does not involve modifying the germ line genetic identity of human beings.
A positive electrode plate comprising a current collector , a positive active material layer and a binding layer disposed between the current collector and the positive active material layer , wherein the binding layer comprises a polymer material, a conductive material and an inorganic filler, wherein the polymer material comprises a binding layer matrix and the binding layer matrix is an oil-dispersible polymer material having a solubility in NMP at 130 °C for 5 minutes, which is 30% or less of the solubility of PVDF under the same conditions.
A smoking article comprising: a tobacco rod adapted to produce mainstream smoke; a filter attached to said tobacco rod , said filter having an upstream end portion and a downstream end portion, said filter comprising: a single central cavity located between said upstream end and said downstream end and defined by an inner periphery of a tubular segment selected from the group consisting of a cellulosic tube, a hollow acetate tube, carbon on tow, carbon paper, and combinations thereof; a flow restricting segment of smoke impermeable material located upstream of said cavity and including at least one flow passage therethrough to deliver mainstream smoke to the cavity and to produce a substantial portion of a predetermined resistance to draw; and a ventilation zone at a location along said cavity and downstream of said flow restricting segment to admix atmospheric air with mainstream smoke. a tobacco rod adapted to produce mainstream smoke; a filter attached to said tobacco rod , said filter having an upstream end portion and a downstream end portion, said filter comprising: a single central cavity located between said upstream end and said downstream end and defined by an inner periphery of a tubular segment selected from the group consisting of a cellulosic tube, a hollow acetate tube, carbon on tow, carbon paper, and combinations thereof; a flow restricting segment of smoke impermeable material located upstream of said cavity and including at least one flow passage therethrough to deliver mainstream smoke to the cavity and to produce a substantial portion of a predetermined resistance to draw; and a ventilation zone at a location along said cavity and downstream of said flow restricting segment to admix atmospheric air with mainstream smoke. a single central cavity located between said upstream end and said downstream end and defined by an inner periphery of a tubular segment selected from the group consisting of a cellulosic tube, a hollow acetate tube, carbon on tow, carbon paper, and combinations thereof; a flow restricting segment of smoke impermeable material located upstream of said cavity and including at least one flow passage therethrough to deliver mainstream smoke to the cavity and to produce a substantial portion of a predetermined resistance to draw; and a ventilation zone at a location along said cavity and downstream of said flow restricting segment to admix atmospheric air with mainstream smoke.
Piece of furniture, with a furniture carcass which has an interior which is bounded at the sides by two opposite side walls wherein, on at least one side wall is mounted a free-ending front base fixture , projecting towards the opposite side wall and having a support bracket extending away from the assigned side wall in a cantilever fashion, and a front base plate mounted on the support bracket , and wherein the side wall is in the form of a double wall with an outer side wall , and an inner side wall mounted in front of the former in the direction of the interior , wherein the support bracket is mounted on the inner side wall , wherein the support bracket has a support section with a rear mounting structure facing the assigned side wall , via which the support bracket is attached to the assigned side wall , characterised in that the mounting structure has first mounting means formed on the support section and second mounting means formed separately from the support section , which are located on a rear side of the assigned side wall and interact with the first mounting means through at least one through hole formed in the side wall for attaching the support bracket .
A computer program product comprising instructions which when executed on the storage device of claim 3 or the system in communication with a storage device of claim 8 manage spare space in the storage device by performing operations, the operations comprising: determining a current write amplification indicative of a ratio of storage writes to a media at the storage device and host writes from a host to the storage device; determining an adjustment to the current write amplification to produce an adjusted write amplification based on an estimated lifespan of the storage device, a maximum storage writes for the storage device, and the storage writes at the storage device since the storage device was powered-on; selecting one of a plurality of write amplification functions provided for different workloads at the storage device based on a current workload at the storage device; determining an adjustment to the spare space based on the adjusted write amplification and using the selected write amplification function, wherein the spare space comprises overprovisioned storage space not comprising user accessible storage; and initiating an operation to reconfigure the spare space and the free space available to the user to adjust the spare space by the determined adjustment to the spare space. determining a current write amplification indicative of a ratio of storage writes to a media at the storage device and host writes from a host to the storage device; determining an adjustment to the current write amplification to produce an adjusted write amplification based on an estimated lifespan of the storage device, a maximum storage writes for the storage device, and the storage writes at the storage device since the storage device was powered-on; selecting one of a plurality of write amplification functions provided for different workloads at the storage device based on a current workload at the storage device; determining an adjustment to the spare space based on the adjusted write amplification and using the selected write amplification function, wherein the spare space comprises overprovisioned storage space not comprising user accessible storage; and initiating an operation to reconfigure the spare space and the free space available to the user to adjust the spare space by the determined adjustment to the spare space.
A method of interpreting an activity of a person on a flexible mat of a trampoline, the method comprising: at least one processor determining a bounce instruction for the person on the flexible mat; determining a first bounce location and a first bounce impact time of the person on the flexible mat; determining a second bounce location and a second bounce impact time of the person on the flexible mat; characterized in that the method further comprises: determining a lead time boundary interval, the lead time boundary interval defined by the first bounce impact time and a time value preceding the first bounce impact time and following an impact time of a bounce preceding the first bounce impact time; responsive to displaying the bounce instruction prior to the time value , the at least one processor comparing the second bounce location and/or second bounce impact time with the bounce instruction; and responsive to displaying the bounce instruction within the lead time boundary interval, the at least one processor determining a third bounce location and a third bounce impact time of the person on the flexible mat and comparing the third bounce location and/or third bounce impact time with the bounce instruction. at least one processor determining a bounce instruction for the person on the flexible mat; determining a first bounce location and a first bounce impact time of the person on the flexible mat; determining a second bounce location and a second bounce impact time of the person on the flexible mat; characterized in that the method further comprises: determining a lead time boundary interval, the lead time boundary interval defined by the first bounce impact time and a time value preceding the first bounce impact time and following an impact time of a bounce preceding the first bounce impact time; responsive to displaying the bounce instruction prior to the time value , the at least one processor comparing the second bounce location and/or second bounce impact time with the bounce instruction; and responsive to displaying the bounce instruction within the lead time boundary interval, the at least one processor determining a third bounce location and a third bounce impact time of the person on the flexible mat and comparing the third bounce location and/or third bounce impact time with the bounce instruction. determining a lead time boundary interval, the lead time boundary interval defined by the first bounce impact time and a time value preceding the first bounce impact time and following an impact time of a bounce preceding the first bounce impact time; responsive to displaying the bounce instruction prior to the time value , the at least one processor comparing the second bounce location and/or second bounce impact time with the bounce instruction; and responsive to displaying the bounce instruction within the lead time boundary interval, the at least one processor determining a third bounce location and a third bounce impact time of the person on the flexible mat and comparing the third bounce location and/or third bounce impact time with the bounce instruction.
An induction burner element for a cooking appliance , the induction burner element comprising: a plurality of injection molded frames positioned in a spaced and concentric relationship, each injection molded frame having at least one lower cavity ; a ferrous member disposed within the at least one lower cavity for each injection molded frame ; and a plurality of wound coils for each injection molded frame , wherein each wound coil corresponds to a respective injection molded frame , characterized in that each injection molded frame has an upper cavity and in that said plurality of wound coils are disposed within the upper cavity of each injection molded frame . a plurality of injection molded frames positioned in a spaced and concentric relationship, each injection molded frame having at least one lower cavity ; a ferrous member disposed within the at least one lower cavity for each injection molded frame ; and a plurality of wound coils for each injection molded frame , wherein each wound coil corresponds to a respective injection molded frame , characterized in that each injection molded frame has an upper cavity and in that said plurality of wound coils are disposed within the upper cavity of each injection molded frame .
A method executable by a media player device to avoid a stall during playback of an adaptive media stream delivered over a network , the method comprising: placing requests from the media player device for segments of the media stream to be delivered to the media device via the network; receiving the requested segments of the media stream in a receive buffer of the media player device for playback of the media stream by the media player device ; monitoring a utilization of the receive buffer to determine a rate of change in the utilization of the receive buffer by performing a linear regression of the buffer utilization; and adjusting future requests for segments of the media stream based upon the determined rate of change in the utilization of the receive buffer , wherein the adjusting comprises placing future requests for future segments having a lower quality than the received segments when the rate of change in the utilization of the receive buffer shows a declining buffer utilization and placing future requests for future segments having a higher quality than the received segments when the rate of change in the utilization of the receive buffer shows an increasing buffer utilization, and wherein the adjusting comprises comparing the determined rate of change in the buffer utilization to each of a plurality of threshold levels and changing the quality level of the future segments when the rate of change passes any of the threshold levels. placing requests from the media player device for segments of the media stream to be delivered to the media device via the network; receiving the requested segments of the media stream in a receive buffer of the media player device for playback of the media stream by the media player device ; monitoring a utilization of the receive buffer to determine a rate of change in the utilization of the receive buffer by performing a linear regression of the buffer utilization; and adjusting future requests for segments of the media stream based upon the determined rate of change in the utilization of the receive buffer , wherein the adjusting comprises placing future requests for future segments having a lower quality than the received segments when the rate of change in the utilization of the receive buffer shows a declining buffer utilization and placing future requests for future segments having a higher quality than the received segments when the rate of change in the utilization of the receive buffer shows an increasing buffer utilization, and wherein the adjusting comprises comparing the determined rate of change in the buffer utilization to each of a plurality of threshold levels and changing the quality level of the future segments when the rate of change passes any of the threshold levels.
A method for traffic density estimation and user localization, the method comprising: sending, from a network component, a request to a plurality of user equipment, UEs, to participate in reporting localization data; receiving from at least some of the UEs a plurality of reports for localization data including no-lock reports, wherein the no-lock reports indicate indoor UEs among the UEs; preprocessing the localization data by eliminating, from the localization data, data increasing total noise to signal ratio; after preprocessing the localization data, processing the localization data using a model that distinguishes between different buildings; and associating the indoor UEs with corresponding buildings using the localization data of the no-lock reports, characterized in that the method further comprises building a radio map that associates each bin in a non-uniform grid of coverage area with a set of radio characteristics, and wherein the non-uniform grid is pre-determined to maximize uniqueness between the radio characteristics such that the radio characteristics determine the non-uniform grid and wherein the localization data comprises radio characteristics from the UEs, and wherein processing the localization data using the model comprises associating, according to the radio map, the radio characteristics in the localization data with corresponding bins in the non-uniform grid of coverage area. sending, from a network component, a request to a plurality of user equipment, UEs, to participate in reporting localization data; receiving from at least some of the UEs a plurality of reports for localization data including no-lock reports, wherein the no-lock reports indicate indoor UEs among the UEs; preprocessing the localization data by eliminating, from the localization data, data increasing total noise to signal ratio; after preprocessing the localization data, processing the localization data using a model that distinguishes between different buildings; and associating the indoor UEs with corresponding buildings using the localization data of the no-lock reports, characterized in that the method further comprises building a radio map that associates each bin in a non-uniform grid of coverage area with a set of radio characteristics, and wherein the non-uniform grid is pre-determined to maximize uniqueness between the radio characteristics such that the radio characteristics determine the non-uniform grid and wherein the localization data comprises radio characteristics from the UEs, and wherein processing the localization data using the model comprises associating, according to the radio map, the radio characteristics in the localization data with corresponding bins in the non-uniform grid of coverage area.
A display device comprising: a display module including a display panel ; at least one pair of first and second spacers disposed at the rear of the display module and fixed to the display module ; and a wall mount assembly disposed at the rear of a back cover and fastened to the first and second spacers while allowing tilting movements of the display module and the first and second spacers , wherein, in a tilting movement, one lateral side of the display module moves up or down from an initial state while the opposite lateral side of the display module moves in the opposite direction, wherein the wall mount assembly includes: a fixing part fixed to a fixed object ; a frame having a pair of first and second tilting holes into which the first and second spacers are respectively inserted, and which guides moving paths of the first and second spacers such that the display module can be tilted in response to the shape of the tilting holes , and a locking part for selectively restricting the moving paths of the first and second spacers inserted into the first and second tilting holes ; and a link connecting the fixing part and the frame to each other. a display module including a display panel ; at least one pair of first and second spacers disposed at the rear of the display module and fixed to the display module ; and a wall mount assembly disposed at the rear of a back cover and fastened to the first and second spacers while allowing tilting movements of the display module and the first and second spacers , wherein, in a tilting movement, one lateral side of the display module moves up or down from an initial state while the opposite lateral side of the display module moves in the opposite direction, wherein the wall mount assembly includes: a fixing part fixed to a fixed object ; a frame having a pair of first and second tilting holes into which the first and second spacers are respectively inserted, and which guides moving paths of the first and second spacers such that the display module can be tilted in response to the shape of the tilting holes , and a locking part for selectively restricting the moving paths of the first and second spacers inserted into the first and second tilting holes ; and a link connecting the fixing part and the frame to each other. a fixing part fixed to a fixed object ; a frame having a pair of first and second tilting holes into which the first and second spacers are respectively inserted, and which guides moving paths of the first and second spacers such that the display module can be tilted in response to the shape of the tilting holes , and a locking part for selectively restricting the moving paths of the first and second spacers inserted into the first and second tilting holes ; and a link connecting the fixing part and the frame to each other.
A compound of the Formula: or a pharmaceutically acceptable salt thereof; wherein B 1 is Z 1 is NR Z ; Z 2 is oxygen; R Z is hydrogen or C 1-4 alkyl; R 1 is R 2 is aryl(C 1-4 alkyl)-; R 3 is methyl; R 9 is independently hydrogen or C 1 - 6 alkyl; R 10 is independently hydrogen, C 1 - 6 alkyl, -CH 2 SH, -CH 2 CH 2 (C=O)NH 2 , -CH 2 CH 2 SCH 3 , -CH 2 -phenyl, -CH 2 OH, -CH(OH)CH 3 , -CH 2 (C=O)OH, -CH 2 CH 2 (C=O)OH, -(CH 2 ) 3 NH(C=NH)NH 2 , or -(CH 2 ) 4 NH 2 ; and R 11 is hydrogen, C 1-8 alkyl, cycloalkyl, aryl, or aryl(C 1-6 alkyl)-. B 1 is Z 1 is NR Z ; Z 2 is oxygen; R Z is hydrogen or C 1-4 alkyl; R 1 is R 2 is aryl(C 1-4 alkyl)-; R 3 is methyl; R 9 is independently hydrogen or C 1 - 6 alkyl; R 10 is independently hydrogen, C 1 - 6 alkyl, -CH 2 SH, -CH 2 CH 2 (C=O)NH 2 , -CH 2 CH 2 SCH 3 , -CH 2 -phenyl, -CH 2 OH, -CH(OH)CH 3 , -CH 2 (C=O)OH, -CH 2 CH 2 (C=O)OH, -(CH 2 ) 3 NH(C=NH)NH 2 , or -(CH 2 ) 4 NH 2 ; and R 11 is hydrogen, C 1-8 alkyl, cycloalkyl, aryl, or aryl(C 1-6 alkyl)-.
An intra-oral scanning system comprising: • a replaceable scanning-tip ; • a scanner device configured to replaceably mount the replaceable scanning-tip ; • an infrared light source configured to emit infrared light, the infrared light source residing in or on the replaceable scanning-tip , whereby the scanning tip provides the infrared light to the teeth; and • an optical element located at the distal end of the scanning-tip with a reflective surface inside the scanning-tip such that when the optical element receives light from a white light source located in the scanning device, the scanning tip provides white light to the teeth, wherein the optical element is configured for receiving the white light as back-reflected from the teeth, such that when the optical element receives the white light from teeth, the scanning-tip provides the white light to a first image sensor in the scanning device, CHARACTERIZED IN THAT the optical element is configured to reflect the white light such that it passes to a first set of pixels on a first image sensor, and the optical element is configured to reflect the infrared light such that it passes to a second set of pixels on the first image sensor. • a replaceable scanning-tip ; • a scanner device configured to replaceably mount the replaceable scanning-tip ; • an infrared light source configured to emit infrared light, the infrared light source residing in or on the replaceable scanning-tip , whereby the scanning tip provides the infrared light to the teeth; and • an optical element located at the distal end of the scanning-tip with a reflective surface inside the scanning-tip such that when the optical element receives light from a white light source located in the scanning device, the scanning tip provides white light to the teeth, wherein the optical element is configured for receiving the white light as back-reflected from the teeth, such that when the optical element receives the white light from teeth, the scanning-tip provides the white light to a first image sensor in the scanning device,