mhurhangee/patent-ind-claim-en huggingface dataset:
A method of screening a test compound for the ability to bind and stabilize a target peptide by binding of the test compound to a binding site of the target peptide in a cell, comprising: (a) providing in the cell a fusion protein comprising (i) the target peptide having a destabilizing mutation, which comprises an amino acid deletion or substitution and which destabilizes the peptide as compared to the non-mutated peptide and (ii) an enzyme fragment for detection ; (b) incubating a mixture of the cell of (a) and the test compound for a period sufficient to allow binding of the test compound to the binding site of the target peptide and to allow for stabilization of the fusion protein by the binding; (c) combining the mixture from step (b) with a label that detects an amount of the enzyme fragment remaining after incubating, wherein an increase in the amount of enzyme fragment detected identifies the test compound as having the ability to stabilize the target peptide by binding to the target peptide. (a) providing in the cell a fusion protein comprising (i) the target peptide having a destabilizing mutation, which comprises an amino acid deletion or substitution and which destabilizes the peptide as compared to the non-mutated peptide and (ii) an enzyme fragment for detection ; (b) incubating a mixture of the cell of (a) and the test compound for a period sufficient to allow binding of the test compound to the binding site of the target peptide and to allow for stabilization of the fusion protein by the binding; (c) combining the mixture from step (b) with a label that detects an amount of the enzyme fragment remaining after incubating, wherein an increase in the amount of enzyme fragment detected identifies the test compound as having the ability to stabilize the target peptide by binding to the target peptide.
A device for a secondary base station (Scell BS), comprising a control module configured to control a communication module, the communication module comprised in the device and being controlled to communicate with a terminal together with a primary base station, using at least two carriers in a configuration where the primary base station provides a primary cell and the secondary base station provides a secondary cell for the terminal, wherein at least a first carrier towards the terminal is established in the primary cell from the primary base station (Source Pcell eNB) and a second carrier is established in the secondary cell towards the terminal from the device; and an interface (X2) towards said primary base station, and wherein the control module is configured to suspend, upon receiving a first instruction from the primary base station that is a source of a handover of the primary cell, ongoing traffic between the device and the terminal on the second carrier, perform predefined re-establishment of one or more protocol layers communicating with their peer layers at the terminal, and resume, upon receiving from a primary base station that is a target of the handover of the primary cell a second instruction indicating successful handover, traffic between the device and the terminal on the second carrier. a control module configured to control a communication module, the communication module comprised in the device and being controlled to communicate with a terminal together with a primary base station, using at least two carriers in a configuration where the primary base station provides a primary cell and the secondary base station provides a secondary cell for the terminal, wherein at least a first carrier towards the terminal is established in the primary cell from the primary base station (Source Pcell eNB) and a second carrier is established in the secondary cell towards the terminal from the device; and an interface (X2) towards said primary base station, and suspend, upon receiving a first instruction from the primary base station that is a source of a handover of the primary cell, ongoing traffic between the device and the terminal on the second carrier, perform predefined re-establishment of one or more protocol layers communicating with their peer layers at the terminal, and resume, upon receiving from a primary base station that is a target of the handover of the primary cell a second instruction indicating successful handover, traffic between the device and the terminal on the second carrier.
A high temperature operable ceramic matrix composite, comprising: a ceramic substrate comprising silicon and boron; wherein the ceramic substrate comprises a SiC-SiC ceramic matrix composite; an environmental barrier coating system comprising a silicon containing bond coat; and a diffusion barrier layer between the ceramic substrate and the silicon containing bond coat, wherein the diffusion barrier layer prevents or reduces diffusion of boron and impurities from the ceramic substrate to the bond coat, wherein the diffusion barrier layer is crystalline silicon nitride and 1 μm to 150 μm thick. a ceramic substrate comprising silicon and boron; wherein the ceramic substrate comprises a SiC-SiC ceramic matrix composite; an environmental barrier coating system comprising a silicon containing bond coat; and a diffusion barrier layer between the ceramic substrate and the silicon containing bond coat, wherein the diffusion barrier layer prevents or reduces diffusion of boron and impurities from the ceramic substrate to the bond coat, wherein the diffusion barrier layer is crystalline silicon nitride and 1 μm to 150 μm thick.
A method of reducing acoustic noise produced by a hybrid power plant having a thermal engine and an electrical motor , the method comprising: driving a propulsor with the hybrid power plant operated at an initial work split ratio and at a power level, the initial work split ratio corresponding to a power provided by the thermal engine divided by a power provided by the electrical motor ; receiving a signal from one or more sensors , the signal indicative of an initial noise signature generated by the hybrid power plant operated at the initial work split ratio and the power level; determining that the initial noise signature generated by the hybrid power plant is above a target noise signature of the hybrid power plant ; determining a work split ratio of the hybrid power plant which will generate a noise signature that is at or below the target noise signature; and operating the hybrid power plant at the work split ratio, wherein the determining that the initial noise signature is above the target noise signature includes determining the target noise signature as a function of a flight phase, wherein the determining of the target noise signature as a function of the flight phase includes determining that the flight phase is cruise; and characterised in that the determining of the target noise signature includes determining a target cabin noise signature corresponding to a cabin noise signature of the hybrid power plant perceived from within a cabin of an aircraft equipped with the hybrid power plant . driving a propulsor with the hybrid power plant operated at an initial work split ratio and at a power level, the initial work split ratio corresponding to a power provided by the thermal engine divided by a power provided by the electrical motor ; receiving a signal from one or more sensors , the signal indicative of an initial noise signature generated by the hybrid power plant operated at the initial work split ratio and the power level; determining that the initial noise signature generated by the hybrid power plant is above a target noise signature of the hybrid power plant ; determining a work split ratio of the hybrid power plant which will generate a noise signature that is at or below the target noise signature; and operating the hybrid power plant at the work split ratio, wherein the determining that the initial noise signature is above the target noise signature includes determining the target noise signature as a function of a flight phase, wherein the determining of the target noise signature as a function of the flight phase includes determining that the flight phase is cruise; and characterised in that the determining of the target noise signature includes determining a target cabin noise signature corresponding to a cabin noise signature of the hybrid power plant perceived from within a cabin of an aircraft equipped with the hybrid power plant .
A method, comprising: by a network functions virtualization orchestrator ,NFVO,: receiving, via a network service ,NS, update request from an operations support system/business support system ,OSS/BSS, a request including a NSInstanceId parameter and an updateType parameter; and removing a physical network function ,PNF, part from an NS instance with the updateType parameter in the NS update request set to RemovePnf; or adding a new PNF part to the NS instance with the updateType parameter in the NS update request set to AddPnf. receiving, via a network service ,NS, update request from an operations support system/business support system ,OSS/BSS, a request including a NSInstanceId parameter and an updateType parameter; and removing a physical network function ,PNF, part from an NS instance with the updateType parameter in the NS update request set to RemovePnf; or adding a new PNF part to the NS instance with the updateType parameter in the NS update request set to AddPnf.
A system for delivery of a high viscosity fluid, comprising: a variable speed pump ; a circuit through which the fluid is pumped by the variable speed pump, the circuit comprising a loop having a plurality of fluid off-takes; and a controller configured to control operation and speed of the variable speed pump : (i) to pump the fluid in the circuit in a high pressure mode, wherein the fluid flows from the variable speed pump into the loop and to the plurality of fluid off-takes in opposing flow directions along the loop in the high pressure mode, and wherein the controller is configured to control the speed of the variable speed pump to maintain a pressure of the fluid in the circuit in the high pressure mode, and (ii) to pump the fluid around the circuit in a single flow direction along the loop, in a low pressure mode during periods when none of the plurality of fluid off-takes are being used. a variable speed pump ; a circuit through which the fluid is pumped by the variable speed pump, the circuit comprising a loop having a plurality of fluid off-takes; and a controller configured to control operation and speed of the variable speed pump : (i) to pump the fluid in the circuit in a high pressure mode, wherein the fluid flows from the variable speed pump into the loop and to the plurality of fluid off-takes in opposing flow directions along the loop in the high pressure mode, and wherein the controller is configured to control the speed of the variable speed pump to maintain a pressure of the fluid in the circuit in the high pressure mode, and (ii) to pump the fluid around the circuit in a single flow direction along the loop, in a low pressure mode during periods when none of the plurality of fluid off-takes are being used. (i) to pump the fluid in the circuit in a high pressure mode, wherein the fluid flows from the variable speed pump into the loop and to the plurality of fluid off-takes in opposing flow directions along the loop in the high pressure mode, and wherein the controller is configured to control the speed of the variable speed pump to maintain a pressure of the fluid in the circuit in the high pressure mode, and (ii) to pump the fluid around the circuit in a single flow direction along the loop, in a low pressure mode during periods when none of the plurality of fluid off-takes are being used.
A smart table comprising: a plate ; an inverter configured to convert direct current (DC) power into alternative current (AC) power and to supply the AC power; and a coil unit disposed below the plate and comprising a plurality of working coils heated by the AC power; a radio frequency identification RFID reader configured to recognize an RFID tag of a home appliance placed on the plate and to receive information on the home appliance from the RFID tag and a processor configured to drive one or more of the plurality of working coils as wireless power transmission coils to perform control to transmit wireless power to the home appliance based on the received information or as working coils for induction heating to heat one or more objects disposed on the plate , characterised in that the RFID reader comprises an antenna disposed on at least one of the plurality of working coils; a spacer or an insulator that is disposed between the antenna of the RFID reader and the at least one of the plurality of working coils. a plate ; an inverter configured to convert direct current (DC) power into alternative current (AC) power and to supply the AC power; and a coil unit disposed below the plate and comprising a plurality of working coils heated by the AC power; a radio frequency identification RFID reader configured to recognize an RFID tag of a home appliance placed on the plate and to receive information on the home appliance from the RFID tag and a processor configured to drive one or more of the plurality of working coils as wireless power transmission coils to perform control to transmit wireless power to the home appliance based on the received information or as working coils for induction heating to heat one or more objects disposed on the plate , characterised in that the RFID reader comprises an antenna disposed on at least one of the plurality of working coils; a spacer or an insulator that is disposed between the antenna of the RFID reader and the at least one of the plurality of working coils.
A post unit (1,1a-b) for safety road barriers, wherein the post unit (1,1a-b) comprises: - a post , - a base part having a hollow body defining a space for receiving the post , and - a fastening member for fastening the post to the base part when the post is inserted into the base part, characterized in that the fastening member is elongated and has an upper portion comprising a fastening arrangement for fastening the fastening member to the post , and a lower portion adapted to be inserted into the space of the base part, the lower portion comprises a protrusion having a first end adapted to be engaged with a first side wall of the base part when the lower portion is inserted in the base part , the fastening arrangement and the post comprises a respective through-hole , and the fastening arrangement comprises fastening means to be arranged in the through-holes for attaching the upper portion of the fastening member to the post . - a post , - a base part having a hollow body defining a space for receiving the post , and - a fastening member for fastening the post to the base part when the post is inserted into the base part, characterized in that the fastening member is elongated and has an upper portion comprising a fastening arrangement for fastening the fastening member to the post , and a lower portion adapted to be inserted into the space of the base part, the lower portion comprises a protrusion having a first end adapted to be engaged with a first side wall of the base part when the lower portion is inserted in the base part , the fastening arrangement and the post comprises a respective through-hole , and the fastening arrangement comprises fastening means to be arranged in the through-holes for attaching the upper portion of the fastening member to the post .
Particulate material comprising rough mesoporous hollow silica nanoparticles, wherein the rough mesoporous hollow silica nanoparticles comprise a mesoporous shell, the external surface of which has projections thereon, the projections having smaller sizes than the particle size, the rough mesoporous hollow silica nanoparticles having a hollow core, the hollow core being defined by a silica shell having a mesoporous structure, the silica shell having a pore structure that includes pores in the range of from 2 nm to 20 nm, the silica shell that surrounds the hollow core having a thickness of from 10 nm to 100 nm, the rough mesoporous hollow silica nanoparticles having silica projections on the surface, spaced apart from each other to provide surface roughness to the particles, the spaced silica projections characterised in that the silica projections comprise strands or cylinders or fibres of silica extending outwardly from the hollow silica nanoparticles, a length of the spaced silica projections ranging from 5 nm up to the diameter of the hollow particle on which they reside, the diameter of the projections being from 2nm to 100 nm, a specific surface area, measured using the nitrogen sorption and BET method, of the nanoparticles ranging from 100m 2 /g to 1000m 2 /g.
A digital load cell with redundancy design, comprising: at least one force measuring element that measures a load force applied to the digital load cell , wherein each force measuring element converts the load force into one analog signal (S_a, S_a1, S_a2); and two or more analog-to-digital conversion modules , and the analog-to-digital conversion module converts the analog signal (S_a, S_a1, S_a2) into a digital signal (S_d, S_d1, S_d2), characterized in that each force measuring element is connected to at least two analog-to-digital conversion modules . at least one force measuring element that measures a load force applied to the digital load cell , wherein each force measuring element converts the load force into one analog signal (S_a, S_a1, S_a2); and two or more analog-to-digital conversion modules , and the analog-to-digital conversion module converts the analog signal (S_a, S_a1, S_a2) into a digital signal (S_d, S_d1, S_d2), characterized in that each force measuring element is connected to at least two analog-to-digital conversion modules .
A method ( 300; 400 ) of dynamically varying a power of a Reference Signal irradiated by at least one radio base station of a radio mobile network ( 100 ; 200 ), said radio base station providing communication services to User Equipment located in at least one respective area served by said radio base station , the method ( 300; 400 ) comprising having a network entity ( 135; 105 ): monitoring at least one performance indicator associated with the at least one area , said at least one performance indicator being indicative of a communication channel state within said at least one area , and either increasing ( 318; 418 ) or decreasing ( 324; 424 ) the power of the Reference Signal in said at least one area on the basis of a current value of said at least one performance indicator, wherein said either increasing ( 318; 418 ) or decreasing ( 324; 424 ) the power of the Reference Signal in said at least one area on the basis of a current value of said at least one performance indicator comprises modifying at least one power parameter referred to power of signals transmitted by said radio base station , characterized in that the communication channel state comprises at least one complex transfer function matrix accounting for transmissions between one or more transmit antennas and one or more receive antennas of said radio base station and User Equipment located in the at least one respective area . monitoring at least one performance indicator associated with the at least one area , said at least one performance indicator being indicative of a communication channel state within said at least one area , and either increasing ( 318; 418 ) or decreasing ( 324; 424 ) the power of the Reference Signal in said at least one area on the basis of a current value of said at least one performance indicator, wherein said either increasing ( 318; 418 ) or decreasing ( 324; 424 ) the power of the Reference Signal in said at least one area on the basis of a current value of said at least one performance indicator comprises modifying at least one power parameter referred to power of signals transmitted by said radio base station , characterized in that the communication channel state comprises at least one complex transfer function matrix accounting for transmissions between one or more transmit antennas and one or more receive antennas of said radio base station and User Equipment located in the at least one respective area .
A variable nozzle device , comprising: a first plate-shaped member having a first plate portion having an annular shape and being fixed to a bearing housing ; a second plate-shaped member having a second plate portion which has an annular shape and which defines a nozzle flow passage between the first plate portion and the second plate portion , the second plate portion having a surface disposed so as to face the first plate portion and another surface disposed so as to face at least partially a scroll flow passage formed inside a turbine housing ; at least one nozzle support having, with respect to an axial direction of the nozzle support, an end coupled to the first plate portion and another end coupled to the second plate portion ; at least one nozzle vane rotatably supported between the first plate portion and the second plate portion ; and a variable nozzle mechanism configured to change a vane angle of the at least one nozzle vane , wherein the first plate portion includes a radially inner portion supporting the nozzle vane and a radially outer portion positioned on a radially outer side of the radially inner portion , wherein the radially inner portion is formed to have a larger thickness T3 than a thickness T2 of the radially outer portion , wherein the first plate-shaped member is a nozzle mount in which the radially inner portion and the radially outer portion are formed integrally, characterized in that the second plate portion is formed to have a larger thickness T1 than the thickness T3 of the radially inner portion and than the first plate portion . a first plate-shaped member having a first plate portion having an annular shape and being fixed to a bearing housing ; a second plate-shaped member having a second plate portion which has an annular shape and which defines a nozzle flow passage between the first plate portion and the second plate portion , the second plate portion having a surface disposed so as to face the first plate portion and another surface disposed so as to face at least partially a scroll flow passage formed inside a turbine housing ; at least one nozzle support having, with respect to an axial direction of the nozzle support, an end coupled to the first plate portion and another end coupled to the second plate portion ; at least one nozzle vane rotatably supported between the first plate portion and the second plate portion ; and a variable nozzle mechanism configured to change a vane angle of the at least one nozzle vane , wherein the first plate portion includes a radially inner portion supporting the nozzle vane and a radially outer portion positioned on a radially outer side of the radially inner portion , wherein the radially inner portion is formed to have a larger thickness T3 than a thickness T2 of the radially outer portion , wherein the first plate-shaped member is a nozzle mount in which the radially inner portion and the radially outer portion are formed integrally, characterized in that the second plate portion is formed to have a larger thickness T1 than the thickness T3 of the radially inner portion and than the first plate portion .