A method for cross-calibration of imagers comprising: modeling a first signal output for each imager of a plurality of imagers (342-1, ... 342-N) to each of a plurality of pre-stored color samples using a pre-stored corresponding imager attribute; modeling a second signal output of a composite of the plurality of the imagers (342-1, ... 342-N) to each of a plurality of pre-stored color samples using the modelled first signal output for each imager and a pre-stored importance weighting corresponding to each of the pre-stored color samples; mapping the first signal output of each of the plurality of imagers (342-1, ... 342-N) by generating a transformation matrix to transform the first signal outputs to a cross-calibrated signal output that comparatively reduces at least some of a difference between the first signal output of the imager and a corresponding second signal output of the composite of the plurality of the imagers; mapping the cross-calibrated signal output to a corresponding reference-calibrated signal output by applying the cross-calibrated signal output into a transformation matrix to transform the cross-calibration signal output to comparatively reduce at least some of a difference between the cross-calibrated signal output and a corresponding reference imager signal output; and converting a third signal output of each of the imagers (342-1, ... 342-N) to coordinates in a device-independent color space by transforming the third signal output with transformation matrices based on the mapping of the corresponding first signal output of the imager to the corresponding cross-calibrated signal output and the mapping of the corresponding cross-calibrated signal output to the corresponding reference-calibrated signal output. modeling a first signal output for each imager of a plurality of imagers (342-1, ... 342-N) to each of a plurality of pre-stored color samples using a pre-stored corresponding imager attribute; modeling a second signal output of a composite of the plurality of the imagers (342-1, ... 342-N) to each of a plurality of pre-stored color samples using the modelled first signal output for each imager and a pre-stored importance weighting corresponding to each of the pre-stored color samples; mapping the first signal output of each of the plurality of imagers (342-1, ... 342-N) by generating a transformation matrix to transform the first signal outputs to a cross-calibrated signal output that comparatively reduces at least some of a difference between the first signal output of the imager and a corresponding second signal output of the composite of the plurality of the imagers; mapping the cross-calibrated signal output to a corresponding reference-calibrated signal output by applying the cross-calibrated signal output into a transformation matrix to transform the cross-calibration signal output to comparatively reduce at least some of a difference between the cross-calibrated signal output and a corresponding reference imager signal output; and converting a third signal output of each of the imagers (342-1, ... 342-N) to coordinates in a device-independent color space by transforming the third signal output with transformation matrices based on the mapping of the corresponding first signal output of the imager to the corresponding cross-calibrated signal output and the mapping of the corresponding cross-calibrated signal output to the corresponding reference-calibrated signal output. <EOS>