A compound of formula I: or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof, wherein: L 1 is straight or branched C 1 -C 5 alkyl substituted with OH; each R 10 and R 10 ' is independently selected from the group consisting of H; C 1 -C 6 alkyl unsubstituted or substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, OPPO 3 -2 M 2 , OP(O)(OH) 2 , OC(O)-C 1 -C 6 alkyl, and OC(O)O-C 1 -C 6 alkyl where M is a monovalent metal cation; and C 3 -C 18 cycloalkyl unsubstituted or substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl provided that no more than one oxygen is attached to any carbon; or R 10 and R 10 ', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is C 3 -C 18 cycloalkyl, aryl, or heteroaryl, any of which are unsubstituted or substituted with one or more substituents selected from the group consisting of OH, CN, halogen, -C 1 -C 6 alkylaryl, -O-C 1 -C 6 alkylaryl, O-R 10 , OPO 3 -2 M 2 , OP(O)(OH) 2 , SH, S-R 10 , C 1 -C 5 alkyl, branched C 1 -C 6 alkyl, NH 2 , NHR 10 , NHS(O) 2 R 10 , N(R 10 )(R 10 '), and NHCOR 10 where M is a monovalent metal cation; X is selected from O, S,-S(O)-, and -S(O) 2 -; Y and Y' are independently H, halogen, or C 1 -C 5 alkyl; L 2 is a bond; R 2 is phenyl unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, OH, OR 10 , CN, NH 2 , NHR 10 , N(R 10 )(R 10 '), SH, SR 10 , SOR 10 , SO 2 R 10 , SO 2 NHR 10 , SO 2 N(R 10 )(R 10 '), CONH 2 , CONR 10 , and CON(R 10 )(R 10 '); wherein aryl is a cyclic, aromatic hydrocarbon group with 1 or 2 aromatic rings; and wherein heteroaryl is a monocyclic, bicyclic or polycyclic aromatic radical of 5 to 10 ring atoms and containing one or more ring heteroatoms selected from N, O or S, the remaining ring atoms being C. L 1 is straight or branched C 1 -C 5 alkyl substituted with OH; each R 10 and R 10 ' is independently selected from the group consisting of H; C 1 -C 6 alkyl unsubstituted or substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, OPPO 3 -2 M 2 , OP(O)(OH) 2 , OC(O)-C 1 -C 6 alkyl, and OC(O)O-C 1 -C 6 alkyl where M is a monovalent metal cation; and C 3 -C 18 cycloalkyl unsubstituted or substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl provided that no more than one oxygen is attached to any carbon; or R 10 and R 10 ', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is C 3 -C 18 cycloalkyl, aryl, or heteroaryl, any of which are unsubstituted or substituted with one or more substituents selected from the group consisting of OH, CN, halogen, -C 1 -C 6 alkylaryl, -O-C 1 -C 6 alkylaryl, O-R 10 , OPO 3 -2 M 2 , OP(O)(OH) 2 , SH, S-R 10 , C 1 -C 5 alkyl, branched C 1 -C 6 alkyl, NH 2 , NHR 10 , NHS(O) 2 R 10 , N(R 10 )(R 10 '), and NHCOR 10 where M is a monovalent metal cation; X is selected from O, S,-S(O)-, and -S(O) 2 -; Y and Y' are independently H, halogen, or C 1 -C 5 alkyl; L 2 is a bond; R 2 is phenyl unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, OH, OR 10 , CN, NH 2 , NHR 10 , N(R 10 )(R 10 '), SH, SR 10 , SOR 10 , SO 2 R 10 , SO 2 NHR 10 , SO 2 N(R 10 )(R 10 '), CONH 2 , CONR 10 , and CON(R 10 )(R 10 '); wherein aryl is a cyclic, aromatic hydrocarbon group with 1 or 2 aromatic rings; and wherein heteroaryl is a monocyclic, bicyclic or polycyclic aromatic radical of 5 to 10 ring atoms and containing one or more ring heteroatoms selected from N, O or S, the remaining ring atoms being C. <EOS>