mhurhangee/patent-ind-claim-en huggingface dataset:
A polypeptide which specifically binds to LRP5 and LRP6, comprising - a first immunoglobulin single variable domain selected from the group of immunoglobulin single variable domains (i) to (iii) defined by comprising the following CDR sequences: (i): CDR1: TYTVG (= SEQ ID NO:1) CDR2: AIRRRGSSTYYADSVKG (= SEQ ID NO:2) CDR3: DTRTVALLQYRYDY (= SEQ ID NO:3) (ii): CDR1: SYAMG (= SEQ ID NO:4) CDR2: AIRRSGRRTYYADSVKG (= SEQ ID NO:5) CDR3: ARRVRSSTRYNTGTWWWEY (= SEQ ID NO:6) (iii): CDR1: RYTMG (= SEQ ID NO:7) CDR2: AIVRSGGSTYYADSVKG (= SEQ ID NO:8) CDR3: DRRGRGENYILLYSSGRYEY (= SEQ ID NO:9), and - a second immunoglobulin single variable domain selected from the group of immunoglobulin single variable domains (iv) and (v) defined by comprising the following CDR sequences: (iv): CDR1: SYAMG (= SEQ ID NO:10) CDR2: AISWSGGSTYYADSVKG (= SEQ ID NO:11) CDR3: SPIPYGSLLRRRNNYDY (= SEQ ID NO:12) (v): CDR1: SYAMG (= SEQ ID NO:13) CDR2: AISWRSGSTYYADSVKG (= SEQ ID NO:14) CDR3: DPRGYGVAYVSAYYEY (= SEQ ID NO:15). - a first immunoglobulin single variable domain selected from the group of immunoglobulin single variable domains (i) to (iii) defined by comprising the following CDR sequences: (i): CDR1: TYTVG (= SEQ ID NO:1) CDR2: AIRRRGSSTYYADSVKG (= SEQ ID NO:2) CDR3: DTRTVALLQYRYDY (= SEQ ID NO:3) (ii): CDR1: SYAMG (= SEQ ID NO:4) CDR2: AIRRSGRRTYYADSVKG (= SEQ ID NO:5) CDR3: ARRVRSSTRYNTGTWWWEY (= SEQ ID NO:6) (iii): CDR1: RYTMG (= SEQ ID NO:7) CDR2: AIVRSGGSTYYADSVKG (= SEQ ID NO:8) CDR3: DRRGRGENYILLYSSGRYEY (= SEQ ID NO:9), and (i): CDR1: TYTVG (= SEQ ID NO:1) CDR2: AIRRRGSSTYYADSVKG (= SEQ ID NO:2) CDR3: DTRTVALLQYRYDY (= SEQ ID NO:3) (ii): CDR1: SYAMG (= SEQ ID NO:4) CDR2: AIRRSGRRTYYADSVKG (= SEQ ID NO:5) CDR3: ARRVRSSTRYNTGTWWWEY (= SEQ ID NO:6) (iii): CDR1: RYTMG (= SEQ ID NO:7) CDR2: AIVRSGGSTYYADSVKG (= SEQ ID NO:8) CDR3: DRRGRGENYILLYSSGRYEY (= SEQ ID NO:9), and - a second immunoglobulin single variable domain selected from the group of immunoglobulin single variable domains (iv) and (v) defined by comprising the following CDR sequences: (iv): CDR1: SYAMG (= SEQ ID NO:10) CDR2: AISWSGGSTYYADSVKG (= SEQ ID NO:11) CDR3: SPIPYGSLLRRRNNYDY (= SEQ ID NO:12) (v): CDR1: SYAMG (= SEQ ID NO:13) CDR2: AISWRSGSTYYADSVKG (= SEQ ID NO:14) CDR3: DPRGYGVAYVSAYYEY (= SEQ ID NO:15). (iv): CDR1: SYAMG (= SEQ ID NO:10) CDR2: AISWSGGSTYYADSVKG (= SEQ ID NO:11) CDR3: SPIPYGSLLRRRNNYDY (= SEQ ID NO:12) (v): CDR1: SYAMG (= SEQ ID NO:13) CDR2: AISWRSGSTYYADSVKG (= SEQ ID NO:14) CDR3: DPRGYGVAYVSAYYEY (= SEQ ID NO:15).
An apparatus for a display, the apparatus comprising: a first light source to illuminate in a first direction a first light guide with a first light, the first light guide directing the first light to a second direction perpendicular to the first direction, the first light source disposed within a cavity of a second light guide , both the second light guide and the cavity coupled to the first light guide in the first direction in a tile assembly without overlapping the first light guide ; a second light source to illuminate in the first direction the second light guide with a second light, the second light guide directing the second light to the second direction, the cavity underlying a sloped surface of the second light guide in a direction opposite to the second direction; and wherein the sloped surface comprises one or more facets and is configured to direct light to the second direction. a first light source to illuminate in a first direction a first light guide with a first light, the first light guide directing the first light to a second direction perpendicular to the first direction, the first light source disposed within a cavity of a second light guide , both the second light guide and the cavity coupled to the first light guide in the first direction in a tile assembly without overlapping the first light guide ; a second light source to illuminate in the first direction the second light guide with a second light, the second light guide directing the second light to the second direction, the cavity underlying a sloped surface of the second light guide in a direction opposite to the second direction; and
An alternating-current, AC - direct current, DC power supply device for converting normal power input through a hot wire (L1), a neutral wire (L2), and a ground wire (L3) to supply AC power between the hot wire (L1) and the neutral wire (L2) and between the hot wire (L1) and the ground wire (L3) and to supply DC power between a conversion neutral wire (L2-1) and the ground wire (L2), the device comprising: a capacitor (C1) including a first terminal that is connected to the neutral wire (L2) and a second terminal that is connected to the conversion neutral wire (L2-1); a first switch (SW1) that is connected to the capacitor (C1) in parallel, a second switch (SW2) including a first terminal connected to the conversion neutral wire (L2-1); a rechargeable battery including a positive terminal connected to a second terminal of the second switch (SW2) and a negative terminal connected to the ground wire (L3); and a switching mode power supply (SMPS) device converting power applied to the hot wire (L1) to a DC voltage having a predetermined voltage level, and supplying the DC voltage to a common terminal of the second switch (SW2) and the rechargeable battery , a battery negative terminal of DC power applied to the neutral wire (L2), and the ground wire (L3). a capacitor (C1) including a first terminal that is connected to the neutral wire (L2) and a second terminal that is connected to the conversion neutral wire (L2-1); a first switch (SW1) that is connected to the capacitor (C1) in parallel, a second switch (SW2) including a first terminal connected to the conversion neutral wire (L2-1); a rechargeable battery including a positive terminal connected to a second terminal of the second switch (SW2) and a negative terminal connected to the ground wire (L3); and a switching mode power supply (SMPS) device converting power applied to the hot wire (L1) to a DC voltage having a predetermined voltage level, and supplying the DC voltage to a common terminal of the second switch (SW2) and the rechargeable battery , a battery negative terminal of DC power applied to the neutral wire (L2), and the ground wire (L3).
A process for producing semiconductor wafers with epitaxial layer deposited from the gas phase in a deposition chamber, comprising the placement of a substrate wafer on a susceptor with circular perimeter by a robot, where the robot moves the substrate wafer into a placement position and places it on the susceptor, with a corrective precept causing the center of the substrate wafer not to lie above the center of the susceptor in the placement position; and the deposition of an epitaxial layer on the substrate wafer, wherein a first number of substrate wafers having a specific resistance which falls within a first range are moved into the placement position by the robot with a first corrective precept, and a second number of substrate wafers having a specific resistance which falls within a second range are moved into the placement position by the robot with a second corrective precept, where the first and second corrective precepts differ from one another. the placement of a substrate wafer on a susceptor with circular perimeter by a robot, where the robot moves the substrate wafer into a placement position and places it on the susceptor, with a corrective precept causing the center of the substrate wafer not to lie above the center of the susceptor in the placement position; and the deposition of an epitaxial layer on the substrate wafer, wherein a first number of substrate wafers having a specific resistance which falls within a first range are moved into the placement position by the robot with a first corrective precept, and a second number of substrate wafers having a specific resistance which falls within a second range are moved into the placement position by the robot with a second corrective precept, where the first and second corrective precepts differ from one another.
High voltage driving circuit arrangement for driving a load of an ultrasonic apparatus, the arrangement being configured to receive a low voltage input signal (LVIN; DINP, DINM) and to generate a high voltage output signal (HVOUT), comprising a short circuit protection circuit , characterized in that said short circuit protection circuit comprises a first electronic switch operated by the low voltage input signal (LVIN; DINP, DINM), and a second electronic switch operated by a low voltage signal (LVOUT) obtained by applying a voltage division (24; 47) to the output high voltage signal (HVOUT), said first electronic switch causing a first pull-up current (M ∗ I 1 ) to be sent to a capacitive element (CL) whose voltage controls the input of a threshold comparator , said second electronic switch causing a second pull-down current (k ∗ N ∗ I 2 ) to be drawn from said capacitive element (CL) whose voltage controls the input of said threshold comparator , said first electronic switch being coupled to a first branch of said protection circuit and said second electronic switch being coupled to a second branch of said protection circuit , said threshold comparator supplying at its output, as a function of the voltage formed on said capacitive element (CL), a short circuit detection signal (SCF) which signals said short circuit (SC) and is capable of disabling the operation of said high voltage driving circuit arrangement .
A transport refrigeration system comprising: a refrigeration unit; a diesel engine powering the refrigeration unit, the diesel engine having an exhaust system for discharging engine exhaust from the diesel engine; an exhaust treatment unit disposed in the diesel engine exhaust system, the exhaust treatment unit including a diesel oxidation catalyst and a diesel particulate filter ; an air control valve configured to control a quantity of air provided to the diesel engine from an air supply fluidly coupled to the diesel engine; and characterised by a controller operably coupled to the air control valve, wherein after initiating regeneration of the diesel particulate filter, the controller is configured to operate the system in one of a primary regeneration mode and a secondary regeneration mode in response to a condition monitored within the exhaust treatment unit; wherein the condition is a rate of temperature change of the exhaust gas and the secondary regeneration mode is used if the rate of temperature change satisfies a pre-determined condition. a diesel engine powering the refrigeration unit, the diesel engine having an exhaust system for discharging engine exhaust from the diesel engine; an exhaust treatment unit disposed in the diesel engine exhaust system, the exhaust treatment unit including a diesel oxidation catalyst and a diesel particulate filter ; an air control valve configured to control a quantity of air provided to the diesel engine from an air supply fluidly coupled to the diesel engine; and characterised by a controller operably coupled to the air control valve, wherein after initiating regeneration of the diesel particulate filter, the controller is configured to operate the system in one of a primary regeneration mode and a secondary regeneration mode in response to a condition monitored within the exhaust treatment unit; wherein the condition is a rate of temperature change of the exhaust gas and the secondary regeneration mode is used if the rate of temperature change satisfies a pre-determined condition.
A vapor deposition coating system for an airfoil portion comprising: a mask configured to be positioned at a position (I) adjacent to a leading edge of an airfoil portion to be coated so as to mask said leading edge ; and means for moving said mask relative to the airfoil portion from said position (I) adjacent said leading edge to a position (II) adjacent a suction side of said airfoil portion so as to mask said suction side ; wherein said means for moving said mask comprises a gear mechanism , said gear mechanism including a gear that is configured to be counter rotationable so as to move said mask back and forth between said position (I) adjacent said leading edge to said position (II) adjacent said suction side of the airfoil portion ; and characterized in that said mask is movable from said position (I) adjacent to said leading edge to said position (II) adjacent said suction side of said airfoil portion between 5 to 20 rotations of the airfoil portion about a longitudinal axis thereof. a mask configured to be positioned at a position (I) adjacent to a leading edge of an airfoil portion to be coated so as to mask said leading edge ; and means for moving said mask relative to the airfoil portion from said position (I) adjacent said leading edge to a position (II) adjacent a suction side of said airfoil portion so as to mask said suction side ; wherein said means for moving said mask comprises a gear mechanism , said gear mechanism including a gear that is configured to be counter rotationable so as to move said mask back and forth between said position (I) adjacent said leading edge to said position (II) adjacent said suction side of the airfoil portion ; and characterized in that said mask is movable from said position (I) adjacent to said leading edge to said position (II) adjacent said suction side of said airfoil portion between 5 to 20 rotations of the airfoil portion about a longitudinal axis thereof.
An antibody-drug conjugate (ADC) comprising a therapeutic agent and an antibody or an antigen-binding fragment that binds Globo H; wherein the therapeutic agent is covalently conjugated to the antibody or the antigen-binding fragment by a linker, wherein the antibody is selected from a monoclonal antibody, an antigen-binding fragment, a chimeric antibody, and a humanized antibody, and wherein the antigen-binding fragment is a Fab, F(ab') 2 , Fv or scFv fragment, and wherein the linker comprises thio groups. wherein the therapeutic agent is covalently conjugated to the antibody or the antigen-binding fragment by a linker, wherein the antibody is selected from a monoclonal antibody, an antigen-binding fragment, a chimeric antibody, and a humanized antibody, and wherein the antigen-binding fragment is a Fab, F(ab') 2 , Fv or scFv fragment, and wherein the linker comprises thio groups.
A method for producing a bioengineered neuronal organoid (BENO) from pluripotent stem cells (PSCs), the method comprising: (A) culturing PSCs, embedded in a matrix immersed in serum-free cell culture medium; (B) culturing the PSCs in said matrix of step (A) in serum-free cell culture medium comprising a Rho-associated kinase inhibitor (ROCKi) and FGF-2; (C) culturing the forming BENO originating from PSCs and matrix of step (B) in serum-free cell culture medium comprising retinoic acid and one or more inhibitors of SMAD signaling to induce neurogenesis; (D) culturing the forming BENO of step (C) in serum-free cell culture medium comprising TGF-beta and FGF-2 to enhance genesis of glial cells and neurogenesis; (E) culturing the forming BENO of step (D) in serum-free cell culture medium comprising TGF-beta and one or more inhibitors of notch signaling to enhance genesis of glial cells and neurodifferentiation, wherein the matrix comprises collagen and wherein the BENO is produced within a 3D environment, wherein the 3D environment is initially defined by the matrix. (A) culturing PSCs, embedded in a matrix immersed in serum-free cell culture medium; (B) culturing the PSCs in said matrix of step (A) in serum-free cell culture medium comprising a Rho-associated kinase inhibitor (ROCKi) and FGF-2; (C) culturing the forming BENO originating from PSCs and matrix of step (B) in serum-free cell culture medium comprising retinoic acid and one or more inhibitors of SMAD signaling to induce neurogenesis; (D) culturing the forming BENO of step (C) in serum-free cell culture medium comprising TGF-beta and FGF-2 to enhance genesis of glial cells and neurogenesis; (E) culturing the forming BENO of step (D) in serum-free cell culture medium comprising TGF-beta and one or more inhibitors of notch signaling to enhance genesis of glial cells and neurodifferentiation, wherein the matrix comprises collagen and wherein the BENO is produced within a 3D environment, wherein the 3D environment is initially defined by the matrix.
A process comprising: transferring, by positive displacement with a positive displacement pump , discrete flow segments from the liquid-enriched exit flow port of a gas-liquid separator between an inlet and an outlet such that said flow segments are not in simultaneous communication at both the inlet and the outlet; and transferring said flow segments at a rate typically unaffected by the presence of positive or negative pressure gradients between said inlet and outlet, thereby providing deterministic drainage rates from said gas-liquid separator . transferring, by positive displacement with a positive displacement pump , discrete flow segments from the liquid-enriched exit flow port of a gas-liquid separator between an inlet and an outlet such that said flow segments are not in simultaneous communication at both the inlet and the outlet; and transferring said flow segments at a rate typically unaffected by the presence of positive or negative pressure gradients between said inlet and outlet, thereby providing deterministic drainage rates from said gas-liquid separator .
Tool comprising a work portion for machining a workpiece and comprising a drive portion which is spaced therefrom, is formed by a flat piece and has a drive profile for coupling to an output profile of a prime mover, by means of which the tool can be moved in particular about an axis in an oscillating or rotating manner, the drive portion having a window that is closed all around and having, in the region of the frame of the window , form-fitting engagement openings (6 to 10) for engagement of form-fitting engagement projections of the output profile, characterised in that the frame of the window has predetermined separation points for breaking out a break-out portion , which predetermined separation points are formed by webs which form outer edges that are formed by incisions introduced into the frame of the window from the outside.
Blender unit for blending materials according to a recipe , comprising: - a number of material hoppers for individual base materials of a base segment of the recipe, the hoppers having an inlet and an outlet ; - a weighing bin that is connected to the outlets of the material hoppers and is configured for weighing the base materials of the base recipe segment; - a mixing chamber having an outlet and a mixing element configured for mixing the base materials received from the weighing bin into a mixture of base materials; - an in-line dosing chamber that is directly connected to the outlet of the mixing chamber and is provided with a number of dosing elements configured for dosing a number of additives of an additive segment of the recipe into the mixture of base materials received from the mixing chamber, and the in-line dosing chamber having a blender outlet ; - a controller configured for controlling the outlet of the material hoppers, weighing bin, mixing element, and dosing elements such that a mixture according to the recipe can be provided at the blender unit, characterized by a number of weight feeders configured for providing the one of more additives of the additive recipe segment to the in-line dosing chamber, wherein the in-line dosing chamber comprises a static mixer . - a number of material hoppers for individual base materials of a base segment of the recipe, the hoppers having an inlet and an outlet ; - a weighing bin that is connected to the outlets of the material hoppers and is configured for weighing the base materials of the base recipe segment; - a mixing chamber having an outlet and a mixing element configured for mixing the base materials received from the weighing bin into a mixture of base materials; - an in-line dosing chamber that is directly connected to the outlet of the mixing chamber and is provided with a number of dosing elements configured for dosing a number of additives of an additive segment of the recipe into the mixture of base materials received from the mixing chamber, and the in-line dosing chamber having a blender outlet ; - a controller configured for controlling the outlet of the material hoppers, weighing bin, mixing element, and dosing elements such that a mixture according to the recipe can be provided at the blender unit,
A crutch comprising: an elongated member having a distal portion and a proximal portion; a hand grip coupled to the proximal portion of the elongated member ; and a forearm support coupled to the proximal portion of the elongated member ; wherein the forearm support includes an elongated body and a first curved member and a second curved member that are rigidly coupled to the elongated body characterized in that the first curved member and the second curved member define a spiral configuration, wherein, when in use, the spiral configuration wraps more than one full turn around the forearm of the patient, and an inner surface of the forearm support corresponds to a three dimensional digital representation of the forearm of the patient created by photogrammetry so that the forearm support provides a custom and personal fit for the patient's limb. an elongated member having a distal portion and a proximal portion; a hand grip coupled to the proximal portion of the elongated member ; and a forearm support coupled to the proximal portion of the elongated member ; wherein the forearm support includes an elongated body and a first curved member and a second curved member that are rigidly coupled to the elongated body characterized in that the first curved member and the second curved member define a spiral configuration, wherein, when in use, the spiral configuration wraps more than one full turn around the forearm of the patient, and an inner surface of the forearm support corresponds to a three dimensional digital representation of the forearm of the patient created by photogrammetry so that the forearm support provides a custom and personal fit for the patient's limb.