mhurhangee/patent-ind-claim-en huggingface dataset:
A solid oral dosage form for administration in combination with a serotonin modulator for use in treating a depressive disorder in a patient, said dosage form comprising 2R,6R-hydroxynorketamine or a pharmaceutically acceptable salt thereof, or a prodrug of 2R,6R-hydroxynorketamine having a structure of Formula Ib, or a pharmaceutically acceptable salt thereof, wherein: (i) R 1 is selected from PO 3 H 2 , SO 3 H, CO 2 H, and R 5 , wherein R 5 is selected from R 2 is H; or (ii) R 1 is H; R 2 is selected from CH 2 OPO 3 H 2 , CH 2 OSO 3 H and R 4 , wherein R 4 is selected from the groups listed in Table 1; wherein said solid oral dosage form and said serotonin modulator are administered simultaneously, sequentially or separately. (i) R 1 is selected from PO 3 H 2 , SO 3 H, CO 2 H, and R 5 , wherein R 5 is selected from R 2 is H; or (ii) R 1 is H; R 2 is selected from CH 2 OPO 3 H 2 , CH 2 OSO 3 H and R 4 , wherein R 4 is selected from the groups listed in Table 1; wherein said solid oral dosage form and said serotonin modulator are administered simultaneously, sequentially or separately.
An apparatus for monitoring mechanical integrity of an eye-safety component of an illuminator , the apparatus comprising: a transducer operable to generate a vibration in the eye-safety component; and a sensor operable to sense the vibration in the eye-safety component and to output a signal representative of the sensed vibration; and a processor operable to: monitor the signal from the sensor; determine if the signal comprises at least one parameter that falls outside of a pre-determined acceptable range, the pre-determined acceptable range being indicative of mechanical integrity of the eye-safety component; and initiate a safety action in response to a determination that the at least one parameter falls outside of the pre-determined acceptable range thereby indicating a loss of mechanical integrity. a transducer operable to generate a vibration in the eye-safety component; and a sensor operable to sense the vibration in the eye-safety component and to output a signal representative of the sensed vibration; and a processor operable to: monitor the signal from the sensor; determine if the signal comprises at least one parameter that falls outside of a pre-determined acceptable range, the pre-determined acceptable range being indicative of mechanical integrity of the eye-safety component; and initiate a safety action in response to a determination that the at least one parameter falls outside of the pre-determined acceptable range thereby indicating a loss of mechanical integrity. monitor the signal from the sensor; determine if the signal comprises at least one parameter that falls outside of a pre-determined acceptable range, the pre-determined acceptable range being indicative of mechanical integrity of the eye-safety component; and initiate a safety action in response to a determination that the at least one parameter falls outside of the pre-determined acceptable range thereby indicating a loss of mechanical integrity.
A recombinant DNA molecule comprising a DNA sequence selected from the group consisting of: a) a DNA sequence with at least 95 percent sequence identity to the full length of SEQ ID NO: 19, wherein the DNA sequence has the promoter activity of SEQ ID NO: 19; b) a DNA sequence comprising SEQ ID NO: 19; c) a fragment comprising at least 300 contiguous nucleotides of SEQ ID NO: 19, wherein the fragment has the promoter activity of SEQ ID NO: 19; wherein said sequence is operably linked to a heterologous transcribable polynucleotide molecule. a) a DNA sequence with at least 95 percent sequence identity to the full length of SEQ ID NO: 19, wherein the DNA sequence has the promoter activity of SEQ ID NO: 19; b) a DNA sequence comprising SEQ ID NO: 19; c) a fragment comprising at least 300 contiguous nucleotides of SEQ ID NO: 19, wherein the fragment has the promoter activity of SEQ ID NO: 19;
A base oil comprising an ester compound obtained by reacting a fatty acid component including a C 4 -C 28 fatty acid and a monohydric alcohol component including at least one C 4 -C 22 straight chain monohydric alcohol and at least one C 4 -C 22 branched chain monohydric alcohol, characterized in that : among said at least one C 4 -C 22 straight chain monohydric alcohol and said at least one C 4 -C 22 branched chain monohydric alcohol, at least one monohydric alcohol has 4 to 11 carbon atoms, at least one monohydric alcohol has 12 to 15 carbon atoms, and at least one monohydric alcohol has 16 to 22 carbon atoms, and said at least one monohydric alcohol having 12 to 15 carbon atoms is present in an amount that ranges from 90.0 wt% to 99.8 wt% based on 100 wt% of said monohydric alcohol component. among said at least one C 4 -C 22 straight chain monohydric alcohol and said at least one C 4 -C 22 branched chain monohydric alcohol, at least one monohydric alcohol has 4 to 11 carbon atoms, at least one monohydric alcohol has 12 to 15 carbon atoms, and at least one monohydric alcohol has 16 to 22 carbon atoms, and said at least one monohydric alcohol having 12 to 15 carbon atoms is present in an amount that ranges from 90.0 wt% to 99.8 wt% based on 100 wt% of said monohydric alcohol component.
A process for obtaining a precursor molecule of insulin or insulin analog having correctly bonded cysteine bridges, which comprises: (a) providing a suspension of inclusion bodies obtained from E. coli host cells, wherein the inclusion bodies comprise precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges; (b) solubilizing the inclusion bodies by adding urea, dithiothreitol (DTT), and ethanolamine to the suspension to provide a solubilization solution, wherein the solubilization solution comprises about 12 to 18 g/L of the precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges, about 3.8 to 4.3 M urea, about 2.2 to 2.8 mM DTT, and about 265 to 365 mM ethanolamine, and has a pH of about 10.5; (c) diluting the solubilization solution about 10-fold with a refold diluent solution comprising ethanolamine and cystamine to provide a refold solution having about 1.2 to 1.8 g/L of the precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges, 0.38 to 0.43 M urea, 345 to 404 μM cystamine, about 0.22 to 0.28 mM DTT, and about 40 mM ethanolamine and has a pH of about 10.5; and (d) incubating the refold solution with stirring to provide aeration for 6 to 12 hours to provide the precursor of insulin or insulin analog having correctly bonded cysteine bridges. (a) providing a suspension of inclusion bodies obtained from E. coli host cells, wherein the inclusion bodies comprise precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges; (b) solubilizing the inclusion bodies by adding urea, dithiothreitol (DTT), and ethanolamine to the suspension to provide a solubilization solution, wherein the solubilization solution comprises about 12 to 18 g/L of the precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges, about 3.8 to 4.3 M urea, about 2.2 to 2.8 mM DTT, and about 265 to 365 mM ethanolamine, and has a pH of about 10.5; (c) diluting the solubilization solution about 10-fold with a refold diluent solution comprising ethanolamine and cystamine to provide a refold solution having about 1.2 to 1.8 g/L of the precursor molecules of insulin or insulin analog having incorrectly bonded cysteine bridges, 0.38 to 0.43 M urea, 345 to 404 μM cystamine, about 0.22 to 0.28 mM DTT, and about 40 mM ethanolamine and has a pH of about 10.5; and (d) incubating the refold solution with stirring to provide aeration for 6 to 12 hours to provide the precursor of insulin or insulin analog having correctly bonded cysteine bridges.
A recombinant microorganism expressing enzymes that catalyze a substrate to product conversion comprising: (a) acetyl-CoA and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; malonyl-CoA and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; and/or maloyl-ACP and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; (b) 6-hydroxy-3-oxo-hexanoyl-CoA to 3,6-dihydroxyhexanoyl-CoA; (c) 3,6-dihydroxyhexanoyl-CoA to 6-hydroxy-2-hexenoyl-CoA; (d) 6-hydroxy-2-hexenoyl-CoA to 6-hydroxyhexanoyl-CoA; and (e) 6-hydroxyhexanoyl-CoA to 6-hydroxycaproic acid, wherein at least one of said enzymes is encoded by an exogenous nucleic acid sequence. (a) acetyl-CoA and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; malonyl-CoA and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; and/or maloyl-ACP and 4-hydroxybutyryl-CoA to 6-hydroxy-3-oxo-hexanoyl-CoA; (b) 6-hydroxy-3-oxo-hexanoyl-CoA to 3,6-dihydroxyhexanoyl-CoA; (c) 3,6-dihydroxyhexanoyl-CoA to 6-hydroxy-2-hexenoyl-CoA; (d) 6-hydroxy-2-hexenoyl-CoA to 6-hydroxyhexanoyl-CoA; and (e) 6-hydroxyhexanoyl-CoA to 6-hydroxycaproic acid,
A method for indicating patient-ventilator interaction, comprising: a) receiving ventilator pressure and flow waveform data; b) applying one or more normalizing constants to said ventilator pressure and flow waveform data to obtain respective normalized ventilator pressure and flow waveform data; wherein the normalizing constant for the ventilator pressure waveform is the inverse of: i) the value of pressure at approximately the time of peak flow; or ii) the value of pressure at the elapsed interval into the breath cycle that is approximately the pressure rise time as set on the mechanical ventilator; and the normalizing constant for the ventilator flow waveform is the inverse of: iii) the value of flow at approximately the time of peak flow; or iv) the value of flow at the elapsed interval into the breath cycle that is approximately the flow rise time as set on the mechanical ventilator. c) calculating a Delta waveform based upon pairwise relationships between said normalized ventilator pressure and flow waveform data; and d) using the presence or absence of peaks and/or valleys of the Delta waveform as an indication of the presence or absence of one or more asynchronous patient-ventilator interactions. a) receiving ventilator pressure and flow waveform data; b) applying one or more normalizing constants to said ventilator pressure and flow waveform data to obtain respective normalized ventilator pressure and flow waveform data; wherein the normalizing constant for the ventilator pressure waveform is the inverse of: i) the value of pressure at approximately the time of peak flow; or ii) the value of pressure at the elapsed interval into the breath cycle that is approximately the pressure rise time as set on the mechanical ventilator; and the normalizing constant for the ventilator flow waveform is the inverse of: iii) the value of flow at approximately the time of peak flow; or iv) the value of flow at the elapsed interval into the breath cycle that is approximately the flow rise time as set on the mechanical ventilator. i) the value of pressure at approximately the time of peak flow; or ii) the value of pressure at the elapsed interval into the breath cycle that is approximately the pressure rise time as set on the mechanical ventilator; iii) the value of flow at approximately the time of peak flow; or iv) the value of flow at the elapsed interval into the breath cycle that is approximately the flow rise time as set on the mechanical ventilator. c) calculating a Delta waveform based upon pairwise relationships between said normalized ventilator pressure and flow waveform data; and d) using the presence or absence of peaks and/or valleys of the Delta waveform as an indication of the presence or absence of one or more asynchronous patient-ventilator interactions.
A computer-implemented method of classifying features of an encrypted video stream to determine video quality of experience, QoE, the method comprising: extracting , from one or more encrypted video streams sent from a content server to at least one user device, at least one stream-related feature; inputting the at least one stream-related feature into a discriminator neural network of a generative adversarial network, GAN, wherein the discriminator neural network is trained to classify the at least one stream-related feature using semi-supervised learning based on labeled data and first unlabeled data, and wherein the discriminator neural network is periodically re-trained using the labeled data and second unlabeled data based at least in part on meeting a predetermined condition; and classifying , by the discriminator neural network, the at least one stream-related feature into at least one class of a plurality of classes, wherein each of the plurality of classes corresponds to a QoE parameter. extracting , from one or more encrypted video streams sent from a content server to at least one user device, at least one stream-related feature; inputting the at least one stream-related feature into a discriminator neural network of a generative adversarial network, GAN, wherein the discriminator neural network is trained to classify the at least one stream-related feature using semi-supervised learning based on labeled data and first unlabeled data, and wherein the discriminator neural network is periodically re-trained using the labeled data and second unlabeled data based at least in part on meeting a predetermined condition; and classifying , by the discriminator neural network, the at least one stream-related feature into at least one class of a plurality of classes, wherein each of the plurality of classes corresponds to a QoE parameter.
Portable electronic device for use in potentially explosive areas, with protection against static charge, comprising a transmitter module having an antenna, and a housing for protection against static discharges , which accommodates the transmitter module and the antenna, wherein at least one part of the housing has a frame structure of frame elements made of antistatic material, with areas disposed therebetween that are made of another material, and the radiation of the antenna and the frame structure are adjusted to each other in such a way that a main radiation direction passes through an area with another material, and wherein the size of each area is a maximum of 20 cm 2 and the housing comprises at least three areas made of the other material. a transmitter module having an antenna, and a housing for protection against static discharges , which accommodates the transmitter module and the antenna, wherein at least one part of the housing has a frame structure of frame elements made of antistatic material, with areas disposed therebetween that are made of another material, and the radiation of the antenna and the frame structure are adjusted to each other in such a way that a main radiation direction passes through an area with another material, and wherein the size of each area is a maximum of 20 cm 2 and the housing comprises at least three areas made of the other material.
A polyvinyl chloride mixture, characterized in comprising the following components based on parts by weight: (a) 100 parts polyvinyl chloride resin, and (b) 2-20 parts toughening modifier; wherein said toughening modifier is rubber powders with 1601%-2200% elongation at break and 5-45wt% weight percentage of chlorine; said elongation at break is tested by GB/T528-2009; the weight percentage of chlorine is tested by the method A of GB/T7139-2002. (a) 100 parts polyvinyl chloride resin, and (b) 2-20 parts toughening modifier;
Assembly for measuring a relative humidity level inside a watch , comprising said watch provided with a movement and a device for determining the humidity level present in the enclosure of a case of this watch , characterized in that the determination device comprises: - a receiver module for receiving at least one acoustic signal from a timepiece component of said movement , and - a control unit connected to said receiver module , said control unit being configured to run a model for evaluating a water vapour content of a gaseous fluid contained inside said enclosure based on said at least one acoustic signal received by the receiver module . - a receiver module for receiving at least one acoustic signal from a timepiece component of said movement , and - a control unit connected to said receiver module ,
A method for pretensioning a tower of a wind power installation , comprising the steps: - providing a tensioning device having a foundation arrangement and a tensioning element , ∘ wherein the foundation arrangement comprises a foundation having an anchor portion and a support portion for supporting a tower wall , and ∘ wherein the foundation arrangement comprises an adapter element having a fastening means for fastening a lower end of the tensioning element for pretensioning a tower for the wind power installation , and a connection means for connecting the adapter element to the anchor portion of the foundation , - fastening a lower end of the tensioning element to a fastening means of the adapter element , - fastening an upper end of the tensioning element to an upper end of the tower , - tensioning the tensioning element at the lower end of the tensioning element and/or at the upper end of the tensioning element , - wherein the tensioning of the tensioning element is effected by reduction of a clearance between the foundation and the adapter element , and - characterized in that a spacer is inserted between the anchor portion and the adapter element . - providing a tensioning device having a foundation arrangement and a tensioning element , ∘ wherein the foundation arrangement comprises a foundation having an anchor portion and a support portion for supporting a tower wall , and ∘ wherein the foundation arrangement comprises an adapter element having a fastening means for fastening a lower end of the tensioning element for pretensioning a tower for the wind power installation , and a connection means for connecting the adapter element to the anchor portion of the foundation , ∘ wherein the foundation arrangement comprises a foundation having an anchor portion and a support portion for supporting a tower wall , and ∘ wherein the foundation arrangement comprises an adapter element having a fastening means for fastening a lower end of the tensioning element for pretensioning a tower for the wind power installation , and a connection means for connecting the adapter element to the anchor portion of the foundation , - fastening a lower end of the tensioning element to a fastening means of the adapter element , - fastening an upper end of the tensioning element to an upper end of the tower , - tensioning the tensioning element at the lower end of the tensioning element and/or at the upper end of the tensioning element , - wherein the tensioning of the tensioning element is effected by reduction of a clearance between the foundation and the adapter element , and - characterized in that a spacer is inserted between the anchor portion and the adapter element .
An exercise system that creates virtual ambulatory and virtual inertial performance environments with simulated ground reaction force vectors that substantially replicate or substantially modify external forces experienced during ambulation, the exercise system comprising: a lower extremity exercise device comprising: - a surface that stabilizes a pelvis of a user in a horizontally fixed pelvis position, the surface connected to a footplate which delivers variable resistance on three planes against which a user reacts with plantar force to perform functional or nonfunctional movement patterns; wherein the variable resistance is varied by a two-way communication between electronics and pneumatic valve controllers ; and - the footplate provides simulated gravitational value and inertial value of the external forces, wherein the simulated gravitational value and the inertial value are varied to substantially mimic multiple lower extremity performance environments, including gravitational environments and ambulation modes and speeds in a manner substantially similar to ambulation, wherein moments of force are created about all seven lower extremity biomechanical axes. - a surface that stabilizes a pelvis of a user in a horizontally fixed pelvis position, the surface connected to a footplate which delivers variable resistance on three planes against which a user reacts with plantar force to perform functional or nonfunctional movement patterns; wherein the variable resistance is varied by a two-way communication between electronics and pneumatic valve controllers ; and - the footplate provides simulated gravitational value and inertial value of the external forces, wherein the simulated gravitational value and the inertial value are varied to substantially mimic multiple lower extremity performance environments, including gravitational environments and ambulation modes and speeds in a manner substantially similar to ambulation, wherein moments of force are created about all seven lower extremity biomechanical axes.
A method of carrying out a chemical reaction which involves the transfer of an element or group X from one chemical species to another, the method comprising sequentially: A) passing a chemical species P through a fixed bed reactor, the chemical species P flowing from a first position of the fixed bed reactor to a second position of the fixed bed reactor, and extracting the resulting chemical species PX y from the second position of the fixed bed reactor; and then B) passing a chemical species QX z through the fixed bed reactor, the chemical species QX z flowing from the second position of the fixed bed reactor to the first position of the fixed bed reactor, and extracting the resulting chemical species Q from the first position of the fixed bed reactor; C) optionally repeating steps A) and B) in sequence at least once; wherein P and Q are chemical species which are selected such that both P and Q can accept the element or group X and both PX y and QX z can donate the element or group X; y and z are integers; and wherein the fixed bed reactor comprises at least one non-stoichiometric material which has the formula M n X p(1-q) where n and p are integers required for stoichiometric bonding between M and X and 0<q<1 or 0>q>-1; wherein the material is able to adopt a range of values of q; and wherein M may represent a single element or a mixture of more than one element. A) passing a chemical species P through a fixed bed reactor, the chemical species P flowing from a first position of the fixed bed reactor to a second position of the fixed bed reactor, and extracting the resulting chemical species PX y from the second position of the fixed bed reactor; and then B) passing a chemical species QX z through the fixed bed reactor, the chemical species QX z flowing from the second position of the fixed bed reactor to the first position of the fixed bed reactor, and extracting the resulting chemical species Q from the first position of the fixed bed reactor; C) optionally repeating steps A) and B) in sequence at least once;