An antibody or antigen-binding fragment thereof, comprising: (i) (a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 1; a CDR2 having the amino acid sequences of SEQ ID NO: 2 or SEQ ID NO: 3; and a CDR3 having the amino acid sequence of SEQ ID NO: 4; and (b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 16; a CDR2 having the amino acid sequence of SEQ ID NO: 17; and a CDR3 having the amino acid sequence of SEQ ID NO: 18; (ii) (a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 5; a CDR2 having the amino acid sequences of SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or SEQ ID NO: 10; and a CDR3 having the amino acid sequence of SEQ ID NO: 11; and (b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequences of SEQ ID NO: 19, SEQ ID NO: 20, or SEQ ID NO: 72; a CDR2 having the amino acid sequences of SEQ ID NO: 21 or SEQ ID NO: 71; and a CDR3 having the amino acid sequence of SEQ ID NO: 22; or (iii) a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 12; a CDR2 having the amino acid sequences of SEQ ID NO: 13 or SEQ ID NO: 14; and a CDR3 having the amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 70; and b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 23; a CDR2 having the amino acid sequence of SEQ ID NO: 24; and a CDR3 having the amino acid sequence of SEQ ID NO: 25. (i) (a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 1; a CDR2 having the amino acid sequences of SEQ ID NO: 2 or SEQ ID NO: 3; and a CDR3 having the amino acid sequence of SEQ ID NO: 4; and (b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 16; a CDR2 having the amino acid sequence of SEQ ID NO: 17; and a CDR3 having the amino acid sequence of SEQ ID NO: 18; (ii) (a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 5; a CDR2 having the amino acid sequences of SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or SEQ ID NO: 10; and a CDR3 having the amino acid sequence of SEQ ID NO: 11; and (b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequences of SEQ ID NO: 19, SEQ ID NO: 20, or SEQ ID NO: 72; a CDR2 having the amino acid sequences of SEQ ID NO: 21 or SEQ ID NO: 71; and a CDR3 having the amino acid sequence of SEQ ID NO: 22; or (iii) a) an immunoglobulin heavy chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 12; a CDR2 having the amino acid sequences of SEQ ID NO: 13 or SEQ ID NO: 14; and a CDR3 having the amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 70; and b) an immunoglobulin light chain variable region comprising a CDR1 having the amino acid sequence of SEQ ID NO: 23; a CDR2 having the amino acid sequence of SEQ ID NO: 24; and a CDR3 having the amino acid sequence of SEQ ID NO: 25. <EOS>