Method for the selective quantification and/or characterisation of A-beta aggregates comprising the following steps: a0) immobilisation of capture molecules on a substrate, wherein the capture molecules are anti-A-Beta antibodies, a) application of the sample to be tested to the substrate, b) addition of probes labelled for detection, wherein the probes are fluorescent dye-labelled anti-A-Beta antibodies which specifically binds to an N-terminal epitope of the A-Beta peptide, which by specific binding to A-Beta aggregates mark these, and c) detection of the marked A-Beta aggregates, wherein the detection is carried out by means of spatial resolution fluorescence microscopy, wherein the detection of monomers is excluded in that signals with a lower intensity are not assessed because of an intensity cut-off, and wherein step a) can be performed before step b) and an internal or external standard for quantification of A-beta aggregates is used, wherein the standard comprises a well-defined number of epitopes from the amino-terminal part of the A-beta peptide selected from A-Beta 1-8 (SEQ ID NO:2), A-Beta 1-11 (SEQ ID No.3 ), A-Beta 1-16 (SEQ ID NO:4 ), A-Beta 3-11 (SEQ ID NO:5), pyroGluA-Beta 3-11 (SEQ ID NO:6), A-BETA 11-16 (SEQ ID NO:7) and/or pyroGLUA-Beta 11-16 (SEQ ID NO:8), which are directly or via amino acids, spacers and/or functional groups covalently linked to one another, and wherein the standard is constructed as a dendrimer. a0) immobilisation of capture molecules on a substrate, wherein the capture molecules are anti-A-Beta antibodies, a) application of the sample to be tested to the substrate, b) addition of probes labelled for detection, wherein the probes are fluorescent dye-labelled anti-A-Beta antibodies which specifically binds to an N-terminal epitope of the A-Beta peptide, which by specific binding to A-Beta aggregates mark these, and c) detection of the marked A-Beta aggregates, wherein the detection is carried out by means of spatial resolution fluorescence microscopy, wherein the detection of monomers is excluded in that signals with a lower intensity are not assessed because of an intensity cut-off, and wherein a) application of the sample to be tested to the substrate, b) addition of probes labelled for detection, wherein the probes are fluorescent dye-labelled anti-A-Beta antibodies which specifically binds to an N-terminal epitope of the A-Beta peptide, which by specific binding to A-Beta aggregates mark these, and c) detection of the marked A-Beta aggregates, wherein the detection is carried out by means of spatial resolution fluorescence microscopy, wherein the detection of monomers is excluded in that signals with a lower intensity are not assessed because of an intensity cut-off, and wherein step a) can be performed before step b) and an internal or external standard for quantification of A-beta aggregates is used, wherein the standard comprises a well-defined number of epitopes from the amino-terminal part of the A-beta peptide selected from A-Beta 1-8 (SEQ ID NO:2), A-Beta 1-11 (SEQ ID No.3 ), A-Beta 1-16 (SEQ ID NO:4 ), A-Beta 3-11 (SEQ ID NO:5), pyroGluA-Beta 3-11 (SEQ ID NO:6), A-BETA 11-16 (SEQ ID NO:7) and/or pyroGLUA-Beta 11-16 (SEQ ID NO:8), which are directly or via amino acids, spacers and/or functional groups covalently linked to one another, and wherein the standard is constructed as a dendrimer. <EOS>