mhurhangee/patent-ind-claim-en huggingface dataset:
A compound, or a pharmaceutically acceptable salt or ester thereof, having formula I, for use in the treatment of prostate cancer, for example castration-resistant prostate cancer; wherein the compound of formula I is: R 20 -(Z) b -(Y) c -(R 21 ) a -X-R 22 -R 23 I wherein R 20 is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl; Z is alkanediyl or substituted alkanediyl, preferably C 1 -C 3 alkanediyl; Y is S, O, or NR 10 , wherein R 10 is H or alkyl; R 21 is cycloalkanediyl or substituted cycloalkanediyl; X is -C(=O)- or -S(=O)(=O)-; R 22 is R 23 is a substituted phenyl having a structure of: wherein each of R 1 -R 5 is individually H, alkyl, halogen, cyano, or substituted alkynyl, provided that at least one of R 1 -R 5 is not H; a is 1; b is 0 or 1; and c is 0 or 1; provided that if X is -C(=O)- then Y is not S; optionally wherein (i) the compound is orally administered; and/or (ii) the compound is used in combination with androgen deprivation therapy, for example wherein the agent is co-administered with abiratrone; and/or (iii) the method further comprises identifying a subject that is in need of treatment with the compound. Z is alkanediyl or substituted alkanediyl, preferably C 1 -C 3 alkanediyl; Y is S, O, or NR 10 , wherein R 10 is H or alkyl; R 21 is cycloalkanediyl or substituted cycloalkanediyl; X is -C(=O)- or -S(=O)(=O)-; R 22 is R 23 is a substituted phenyl having a structure of: wherein each of R 1 -R 5 is individually H, alkyl, halogen, cyano, or substituted alkynyl, provided that at least one of R 1 -R 5 is not H; a is 1; b is 0 or 1; and c is 0 or 1; provided that if X is -C(=O)- then Y is not S; (i) the compound is orally administered; and/or (ii) the compound is used in combination with androgen deprivation therapy, for example wherein the agent is co-administered with abiratrone; and/or (iii) the method further comprises identifying a subject that is in need of treatment with the compound.
An operation method performed by a terminal in a wireless communication system, the operation method comprising: receiving, from a base station through higher layer signaling, a subcarrier spacing configuration indicating a subcarrier spacing of 60 kHz and cyclic prefix information indicating an extended cyclic prefix; receiving a slot format indicator with a normal cyclic prefix; and determining a symbol of a slot format with the extended cyclic prefix as a flexible symbol in case that symbols of a slot format with the normal cyclic prefix that overlap the symbol of the slot format with the extended cyclic prefix include a downlink symbol and an uplink symbol. receiving, from a base station through higher layer signaling, a subcarrier spacing configuration indicating a subcarrier spacing of 60 kHz and cyclic prefix information indicating an extended cyclic prefix; receiving a slot format indicator with a normal cyclic prefix; and determining a symbol of a slot format with the extended cyclic prefix as a flexible symbol in case that symbols of a slot format with the normal cyclic prefix that overlap the symbol of the slot format with the extended cyclic prefix include a downlink symbol and an uplink symbol.
Gearbox assembly , in particular for an agricultural working vehicle comprising a parallel-shift gearbox with a plurality of gear stages and an input shaft , starting from which drive power can be distributed respectively via a first and a second switching element to respective layshafts , and an output shaft , wherein the drive power can be transmitted as necessary to the output shaft from each of the layshafts , a group-shift gearbox having a plurality of shifting groups (821, 822,...) and an output shaft , wherein the drive from the shifting groups (821, 822,...) can be connected to the output shaft of the parallel-shift gearbox , in order to conduct the drive power to the output shaft of the group-shift gearbox , characterized by a coupling transmission stage , with which the drive power can be conducted from one of the layshafts to the output shaft of the group-shift gearbox while bypassing the switching groups (821, 822,...) of the group-shift gearbox .
A pharmaceutical composition for synergistically enhanced delivery of one or more encapsulated polynucleotides to one or more target cells, for use in a method of treating or preventing a disease or disorder relating to deficiency of one or more proteins and/or enzymes, said composition comprising mRNA as a first encapsulated polynucleotide and a blend of at least a first lipid nanoparticle and a second lipid nanoparticle, wherein the first lipid nanoparticle encapsulates one or more polynucleotides; and wherein the first lipid nanoparticle comprises at least one lipid distinct from the second lipid nanoparticle.
A tunable microring resonator , comprising: - a primary waveguide having first and second ends ; - a plurality of secondary waveguides each having a different length and each having first and second ends ; and - a Micro-Electro-Mechanical System (MEMS) adjustable to optically couple at least a first end of the primary waveguide with a first respective end of a selected secondary waveguide thereby allowing light to circulate within the tunable microring resonator. - a primary waveguide having first and second ends ; - a plurality of secondary waveguides each having a different length and each having first and second ends ; and - a Micro-Electro-Mechanical System (MEMS) adjustable to optically couple at least a first end of the primary waveguide with a first respective end of a selected secondary waveguide thereby allowing light to circulate within the tunable microring resonator.
A solid spherical toilet block comprising at least a first composition and a second composition , wherein the first composition differs from the second composition and the production of the toilet block comprises a non-concentric coextrusion step, wherein the first composition is in spatial contact with a sub-area of the side wall of the passage and the second composition is in spatial contact with another part of the side wall , wherein, by means of a forming step, the extrudate is formed into a sphere using a rolling machine and the toilet block thus has essentially a spherical geometry, wherein the two compositions are interwoven with each other in a streak-like manner on the surface of the spherical toilet block.
Method of MR imaging of at least a portion of a body placed within the examination volume of a MR device , the method comprising the steps of: - determining the presence of a metal implant in the body , - subjecting the portion of the body to a first imaging sequence of RF pulses and switched magnetic field gradients, wherein first MR signals are acquired via at least two RF coils having different spatial sensitivity profiles within the examination volume, - deriving the spatial sensitivity profiles of the at least two RF coils from the acquired first MR signals, - subjecting the portion of the body to a second imaging sequence of RF pulses and switched magnetic field gradients, wherein second MR signals are acquired by parallel acquisition via the at least two RF coils with sub-sampling of k-space, - reconstructing a MR image from the acquired second MR signals and from the spatial sensitivity profiles of the at least two RF coils , wherein the MR image is reconstructed by using a SENSE algorithm, and wherein the type of the first imaging sequence is selected automatically depending on the determination of the presence of a metal implant in the body , wherein the selection of the type of the first imaging sequence is made between - a gradient echo sequence, if no metal implant is present, and - a stimulated echo sequence, if a metal implant is present. - determining the presence of a metal implant in the body , - subjecting the portion of the body to a first imaging sequence of RF pulses and switched magnetic field gradients, wherein first MR signals are acquired via at least two RF coils having different spatial sensitivity profiles within the examination volume, - deriving the spatial sensitivity profiles of the at least two RF coils from the acquired first MR signals, - subjecting the portion of the body to a second imaging sequence of RF pulses and switched magnetic field gradients, wherein second MR signals are acquired by parallel acquisition via the at least two RF coils with sub-sampling of k-space, - reconstructing a MR image from the acquired second MR signals and from the spatial sensitivity profiles of the at least two RF coils , wherein the MR image is reconstructed by using a SENSE algorithm, and - a gradient echo sequence, if no metal implant is present, and - a stimulated echo sequence, if a metal implant is present.
A no-back device comprising: a flange arranged to receive torque via a shaft ; a ratchet assembly comprising a ratchet wheel arranged parallel to the flange; and a braking assembly comprising a resistance wheel , which is sandwiched between the flange and the ratchet wheel, and a braking device , which acts on the resistance wheel to generate a resistive angular force reacting against torque exerted on the resistance wheel, the resistance wheel comprising a plurality of rollable thrust members to transfer axial load directly from the flange to the ratchet wheel, characterised in that the braking device comprises a follower arranged to roll, under bias from a spring in the braking device, on a cam surface extending around a circumferential perimeter of the resistance wheel, and whereby radial displacement of the follower energises the spring to generate resistive angular force. a flange arranged to receive torque via a shaft ; a ratchet assembly comprising a ratchet wheel arranged parallel to the flange; and a braking assembly comprising a resistance wheel , which is sandwiched between the flange and the ratchet wheel, and a braking device , which acts on the resistance wheel to generate a resistive angular force reacting against torque exerted on the resistance wheel, the resistance wheel comprising a plurality of rollable thrust members to transfer axial load directly from the flange to the ratchet wheel, characterised in that the braking device comprises a follower arranged to roll, under bias from a spring in the braking device, on a cam surface extending around a circumferential perimeter of the resistance wheel, and whereby radial displacement of the follower energises the spring to generate resistive angular force.
A computer-implemented method for generating stereoscopic images to supplement existing content, the method comprising: obtaining first image data; obtaining second image data, the second image data being a 2D image comprising a plurality of sample points, wherein a direction, a color value, and a depth value are associated with each sample point, and wherein the directions and depth values are relative to a common origin; generating a mesh, wherein generating the mesh includes displacing the sample points from the common origin in the directions associated with the sample points by distances representative of the corresponding depth values; mapping the second image data to the mesh, wherein the color values associated with the sample points are mapped to the mesh at the corresponding directions; generating a first stereoscopic image of an inner surface of the mesh from a first perspective; generating a second stereoscopic image of the inner surface of the mesh from a second perspective; displaying of the first image data on a first portion of a display; and displaying of at least part of the first stereoscopic image and at least part of the second stereoscopic image on a second portion of the display, wherein at least part of the second portion of the display surrounds the first portion of the display. obtaining first image data; obtaining second image data, the second image data being a 2D image comprising a plurality of sample points, wherein a direction, a color value, and a depth value are associated with each sample point, and wherein the directions and depth values are relative to a common origin; wherein a direction, a color value, and a depth value are associated with each sample point, and wherein the directions and depth values are relative to a common origin; generating a mesh, wherein generating the mesh includes displacing the sample points from the common origin in the directions associated with the sample points by distances representative of the corresponding depth values; mapping the second image data to the mesh, wherein the color values associated with the sample points are mapped to the mesh at the corresponding directions; generating a first stereoscopic image of an inner surface of the mesh from a first perspective; generating a second stereoscopic image of the inner surface of the mesh from a second perspective; displaying of the first image data on a first portion of a display; and displaying of at least part of the first stereoscopic image and at least part of the second stereoscopic image on a second portion of the display, wherein at least part of the second portion of the display surrounds the first portion of the display.
A photovoltaic cell comprising, in succession, an N-layer, an active layer and a P-layer, the N-layer comprising particles of metal oxide (np) and at least one pyridinium compound (Pyr-X) with formula C 5 H 4 R 1 NR 2 + X - : R 1 and R 2 , independently of one another, being a C 1 -C 8 hydrocarbon group, X - being an anion, the N-layer having a np/Pyr-X weight ratio in the range 97/3 to 75/25. the N-layer comprising particles of metal oxide (np) and at least one pyridinium compound (Pyr-X) with formula C 5 H 4 R 1 NR 2 + X - : R 1 and R 2 , independently of one another, being a C 1 -C 8 hydrocarbon group, X - being an anion, the N-layer having a np/Pyr-X weight ratio in the range 97/3 to 75/25.
A DC to AC power converter including first (Q 1 ) and second (Q 2 ) IGBTs each provided with a gate , a collector and an emitter , the emitter of the second IGBT (Q 2 ) is coupled to the collector of the first IGBT (Q 1 ) whereby the connection defines an output of the power converter , the gate of each IGBT is connected to a corresponding gate driver including a reference terminal; the gate driver reference terminal of the first IGBT (Q 1 ) being connected to a ground bus (GND) of the power converter while the gate driver reference terminal of the second IGBT (Q 2 ) being connected to the collector of the first IGBT (Q 1 ); the parasitic inductance (L e-high ) of the emitter of the second IGBT (Q 2 ) being increased to limit an overvoltage at turn off of the second IGBT (Q 2 ) characterized in that the power converter further includes a transformer having a primary (Tla) connected across a parasitic inductance (L c-high ) of the collector of the second IGBT (Q 2 ) and a secondary (T1b), wherein the gate driver reference terminal of the second IGBT (O 2 ) is connected to the collector of the first IGBT (Q 1 ) via the secondary (T1b) of the transformer, and the parasitic inductance (L e-high ) of the emitter of the second IGBT (Q 2 ) seen by the gate driver reference terminal of the second IGBT (Q 2 ) is increased by the secondary (T1b) of the transformer.
An image inspection device which uses photographic images to inspect a target (W), comprising: a photographing portion that photographs the target (W); and a light transmissible lighting portion that is disposed between the target (W) and the photographing portion and configured to irradiate light in a direction toward the target (W); wherein the lighting portion comprises: a plurality of lighting elements that is arranged in a matrix form and configured to be capable of selectively emitting light; and an optical system configured to control irradiation directions of the light emitted from each of the plurality lighting elements to be directions corresponding to positions of each of the plurality of lighting elements , the image inspection device being characterized in that each of the lighting elements includes a light-emitting region and a transparent region, and each of the lighting elements is light transmissible by having the transparent region. a photographing portion that photographs the target (W); and a light transmissible lighting portion that is disposed between the target (W) and the photographing portion and configured to irradiate light in a direction toward the target (W); wherein the lighting portion comprises: a plurality of lighting elements that is arranged in a matrix form and configured to be capable of selectively emitting light; and an optical system configured to control irradiation directions of the light emitted from each of the plurality lighting elements to be directions corresponding to positions of each of the plurality of lighting elements , the image inspection device being characterized in that each of the lighting elements includes a light-emitting region and a transparent region, and each of the lighting elements is light transmissible by having the transparent region. a plurality of lighting elements that is arranged in a matrix form and configured to be capable of selectively emitting light; and an optical system configured to control irradiation directions of the light emitted from each of the plurality lighting elements to be directions corresponding to positions of each of the plurality of lighting elements , the image inspection device being characterized in that each of the lighting elements includes a light-emitting region and a transparent region, and each of the lighting elements is light transmissible by having the transparent region.
A method for detection of an Equivalent Isotropically Radiated Power, EIRP, degradation of a radio frequency, RF, transmitter of a satellite being in an orbit with a repeating ground track, the method comprising: obtaining sets of signal-to-noise, C/N 0 , data from a first source and obtaining satellite orbit data of the satellite from a second source, wherein each set of C/N 0 data is associated with the satellite and a respective one of a plurality of receivers; computing temporal information on an elevational and azimuthal direction of the satellite with respect to respective locations of each of the plurality of receivers based on the satellite orbit data and the respective locations of each of the plurality of receivers; determining a time interval based on the temporal information, in which time interval the repeating ground track repeats a single time; determining , for each of the plurality of receivers, a respective one of a first plurality of differences between a first value of the respective set of C/N 0 data corresponding to a first time point and a second value of the respective set of C/N 0 data corresponding to a second time point, wherein the first and second time points are apart by the time interval; computing a first average of the first plurality of differences; comparing the computed first average with a predetermined threshold; and triggering a signal, which indicates detection of the EIRP degradation of the transmitter when the computed first average is larger than the predetermined threshold. obtaining sets of signal-to-noise, C/N 0 , data from a first source and obtaining satellite orbit data of the satellite from a second source, wherein each set of C/N 0 data is associated with the satellite and a respective one of a plurality of receivers; computing temporal information on an elevational and azimuthal direction of the satellite with respect to respective locations of each of the plurality of receivers based on the satellite orbit data and the respective locations of each of the plurality of receivers; determining a time interval based on the temporal information, in which time interval the repeating ground track repeats a single time; determining , for each of the plurality of receivers, a respective one of a first plurality of differences between a first value of the respective set of C/N 0 data corresponding to a first time point and a second value of the respective set of C/N 0 data corresponding to a second time point, wherein the first and second time points are apart by the time interval; computing a first average of the first plurality of differences; comparing the computed first average with a predetermined threshold; and triggering a signal, which indicates detection of the EIRP degradation of the transmitter when the computed first average is larger than the predetermined threshold.
A high-pressure spray nozzle assembly having a nozzle body and nozzle cap , which are operatively coupled and co-operatively house a retainer having a clasp for retaining wear components , characterized in that the nozzle cap has an open-stepped detent which is formed in relief on an internal peripheral surface of the nozzle cap, wherein the open-stepped detent permits sealing of the retainer against the nozzle cap as a consequence of hydraulic pressure applied by fluid delivered through the high-pressure spray nozzle assembly during operation.
An oxygen carrier composition comprising: a synthetic polymer vesicle comprising a plurality of cross-linked block copolymer chains, wherein each block copolymer chain comprises: at least one hydrophilic polymer block; and at least one hydrophobic polymer block; and at least one polymerizable group conjugated to the at least one hydrophobic polymer block or hydrophilic polymer block; and an oxygen-binding compound, an initiator molecule, wherein at least one of the plurality of block copolymer chains is a diblock copolymer chain in which the at least one hydrophobic polymer block is poly(ε-caprolactone) (PCL), the at least one hydrophilic polymer block is poly(ethylene oxide) (PEO), and the weight fraction of the poly(ethylene oxide) (PEO) is from about 11 to about 20 percent of the total weight of the diblock copolymer chain, and wherein the cross-links between copolymer chains are the result of a polymerization reaction activated by the initiator molecule. a synthetic polymer vesicle comprising a plurality of cross-linked block copolymer chains, wherein each block copolymer chain comprises: at least one hydrophilic polymer block; and at least one hydrophobic polymer block; and at least one polymerizable group conjugated to the at least one hydrophobic polymer block or hydrophilic polymer block; and at least one hydrophilic polymer block; and at least one hydrophobic polymer block; and at least one polymerizable group conjugated to the at least one hydrophobic polymer block or hydrophilic polymer block; and an oxygen-binding compound, an initiator molecule, wherein at least one of the plurality of block copolymer chains is a diblock copolymer chain in which the at least one hydrophobic polymer block is poly(ε-caprolactone) (PCL), the at least one hydrophilic polymer block is poly(ethylene oxide) (PEO), and the weight fraction of the poly(ethylene oxide) (PEO) is from about 11 to about 20 percent of the total weight of the diblock copolymer chain, and wherein the cross-links between copolymer chains are the result of a polymerization reaction activated by the initiator molecule.
A computer implemented method for identifying a gain parameter value for ultrasound hemodynamic analysis, the method comprising: obtaining a B-mode ultrasound image of a blood vessel; and determining a global B-mode gain value which results in a global image entropy of the B-mode ultrasound image being within a target entropy range; characterized by identifying a region of interest of the B-mode ultrasound image resulting from the global B-mode gain value; and determining an output B-mode gain value based on a contrast-to-noise ratio of the region of interest. obtaining a B-mode ultrasound image of a blood vessel; and determining a global B-mode gain value which results in a global image entropy of the B-mode ultrasound image being within a target entropy range; characterized by identifying a region of interest of the B-mode ultrasound image resulting from the global B-mode gain value; and determining an output B-mode gain value based on a contrast-to-noise ratio of the region of interest.