mhurhangee/patent-ind-claim-en huggingface dataset:
A laminate heat exchanger assembly comprising a plurality of heat exchange plates , each heat exchange plate comprising a plate body having a first side and a second side opposed to the first side , a plurality of pins extending from the first side to the second side of an adjacent heat exchange plate , and a plurality of recesses formed in the second side of the plate ; wherein: the recesses are aligned with the pins and the pins of a first heat exchange plate are received within the recesses of an adjacent heat exchange plate ; and by further comprising a braze joint between the pins of one heat exchange plate and the recesses of the adjacent heat exchange plate , wherein the braze joint fills a space formed between end surfaces of the pins of the heat exchange plate and base surfaces of the recesses of the adjacent heat exchange plate and wherein the braze joint further includes a fillet between an outer wall of the pins and the adjacent second side of the adjacent heat exchanger plate ; wherein the recesses each have a planar surface; characterised in that J Z wherein the pins are cylindrical; and wherein the recesses are formed with a radiused edge , wherein the end surfaces of the pins are formed with a peripheral chamfer and wherein the radius of curvature of the peripheral chamfer of the pin is smaller than the radius of curvature of the recess edge whereby a gap is formed between the radiused edge of the recess and the peripheral chamfer of the pin received in the recess , the radiused edge of the recess and the peripheral chamfer forming the gap, the gap being filled with braze material. the recesses are aligned with the pins and the pins of a first heat exchange plate are received within the recesses of an adjacent heat exchange plate ; and by further comprising a braze joint between the pins of one heat exchange plate and the recesses of the adjacent heat exchange plate , wherein the braze joint fills a space formed between end surfaces of the pins of the heat exchange plate and base surfaces of the recesses of the adjacent heat exchange plate and wherein the braze joint further includes a fillet between an outer wall of the pins and the adjacent second side of the adjacent heat exchanger plate ; wherein the recesses each have a planar surface; characterised in that J Z wherein the pins are cylindrical; and wherein the recesses are formed with a radiused edge , wherein the end surfaces of the pins are formed with a peripheral chamfer and wherein the radius of curvature of the peripheral chamfer of the pin is smaller than the radius of curvature of the recess edge whereby a gap is formed between the radiused edge of the recess and the peripheral chamfer of the pin received in the recess , the radiused edge of the recess and the peripheral chamfer forming the gap, the gap being filled with braze material.
A skin attachment device , comprising: an annular ring having a central aperture extending therethrough and defining an inside surface, wherein: the central aperture is circular in shape, the annular ring further comprises a groove extending annularly around an outside surface of the annular ring thereby defining upper and lower lips, the upper lip comprises one or more vertical apertures extending therethough adapted to accept a suture , and the groove is texturized to promote tissue ingrowth upon implantation of the skin attachment device ; and a fixturing assembly adapted to couple to the annular ring via one or more fasteners. the central aperture is circular in shape, the annular ring further comprises a groove extending annularly around an outside surface of the annular ring thereby defining upper and lower lips, the upper lip comprises one or more vertical apertures extending therethough adapted to accept a suture , and the groove is texturized to promote tissue ingrowth upon implantation of the skin attachment device ; and a fixturing assembly adapted to couple to the annular ring via one or more fasteners.
A method performed by a data processing system configured to generate probabilistic data for planning a well depth for subsurface exploration, the method comprising: receiving data representing a plurality of depth maps for a subsurface region, each depth map of the plurality of depth maps having been generated from seismic data acquired in a seismic survey at a location in the subsurface region, wherein the plurality of depth maps represent different interpretation and velocity model scenarios (202a-i) for a particular region; determining , for one or more depth maps of the plurality, a respective weight value; generating data representing a combination of the plurality of depth maps based on the respective weight values of the one or more depth maps of the plurality; generating a cumulative distribution function, i.e., CDF, for a particular location in the subsurface region based on the data representing a combination of the plurality of depth maps; and determining , for the particular location in the subsurface region based on the CDF for that particular location, a probability value representing a depth at which a geological layer occurs in the subsurface region at the particular location. receiving data representing a plurality of depth maps for a subsurface region, each depth map of the plurality of depth maps having been generated from seismic data acquired in a seismic survey at a location in the subsurface region, wherein the plurality of depth maps represent different interpretation and velocity model scenarios (202a-i) for a particular region; determining , for one or more depth maps of the plurality, a respective weight value; generating data representing a combination of the plurality of depth maps based on the respective weight values of the one or more depth maps of the plurality; generating a cumulative distribution function, i.e., CDF, for a particular location in the subsurface region based on the data representing a combination of the plurality of depth maps; and determining , for the particular location in the subsurface region based on the CDF for that particular location, a probability value representing a depth at which a geological layer occurs in the subsurface region at the particular location.
A modified Coversin polypeptide which exhibits leukotriene or hydroxyeicosanoid binding activity and reduced or absent C5 binding, said modified Coversin polypeptide comprising SEQ ID NO: 3 in which up to 30 amino acid substitutions are made, wherein (i) in positions 114 to 124 of SEQ ID NO: 3 the following substitutions (a)-(e) are made: a. Met116 is replaced with Gln, Asp, Asn, Glu, Arg, Lys, Gly, Ala, Pro, His, or Thr; b. Leu117 is replaced with Ser, Asp, Asn, Glu, Arg, Lys, Gly, Ala, or Pro; c. Gly121 is replaced with Ala, Asp, Asn, Glu, Arg, Lys, Leu, Ile, Phe, Tyr, Met, Pro, or His; d. Leu122 is replaced with Asp, Glu, Asn, Ala, Gln, Arg, Lys, Pro, or His; and e. Glu123 is replaced with Ala, Asp, Gln, Asn, Arg, Lys, Gly, Leu, Ser, Ile, Phe, Tyr, Pro, His, or Thr; and wherein (ii) Ala44 in SEQ ID NO: 3 is replaced with Asn, Asp, Gln, Glu, Arg, Lys, Leu, Ile, Phe, Tyr, Met, Pro, or His; and wherein (iii) Asp149 in SEQ ID NO: 3 is replaced with Gly, Gln, Asn, Ala, Met, Arg, Lys, Leu, Ser, Ile, Phe, Tyr, Pro, His, or Thr, and wherein (iv) Met114, Trp115, Asp118, Ala119, Gly120, and Val124 are not substituted, or a fragment thereof in which up to five amino acids are deleted from the N terminus of the modified Coversin polypeptide. (i) in positions 114 to 124 of SEQ ID NO: 3 the following substitutions (a)-(e) are made: a. Met116 is replaced with Gln, Asp, Asn, Glu, Arg, Lys, Gly, Ala, Pro, His, or Thr; b. Leu117 is replaced with Ser, Asp, Asn, Glu, Arg, Lys, Gly, Ala, or Pro; c. Gly121 is replaced with Ala, Asp, Asn, Glu, Arg, Lys, Leu, Ile, Phe, Tyr, Met, Pro, or His; d. Leu122 is replaced with Asp, Glu, Asn, Ala, Gln, Arg, Lys, Pro, or His; and e. Glu123 is replaced with Ala, Asp, Gln, Asn, Arg, Lys, Gly, Leu, Ser, Ile, Phe, Tyr, Pro, His, or Thr; and wherein a. Met116 is replaced with Gln, Asp, Asn, Glu, Arg, Lys, Gly, Ala, Pro, His, or Thr; b. Leu117 is replaced with Ser, Asp, Asn, Glu, Arg, Lys, Gly, Ala, or Pro; c. Gly121 is replaced with Ala, Asp, Asn, Glu, Arg, Lys, Leu, Ile, Phe, Tyr, Met, Pro, or His; d. Leu122 is replaced with Asp, Glu, Asn, Ala, Gln, Arg, Lys, Pro, or His; and e. Glu123 is replaced with Ala, Asp, Gln, Asn, Arg, Lys, Gly, Leu, Ser, Ile, Phe, Tyr, Pro, His, or Thr; and wherein (ii) Ala44 in SEQ ID NO: 3 is replaced with Asn, Asp, Gln, Glu, Arg, Lys, Leu, Ile, Phe, Tyr, Met, Pro, or His; and wherein (iii) Asp149 in SEQ ID NO: 3 is replaced with Gly, Gln, Asn, Ala, Met, Arg, Lys, Leu, Ser, Ile, Phe, Tyr, Pro, His, or Thr, and wherein (iv) Met114, Trp115, Asp118, Ala119, Gly120, and Val124 are not substituted,
An internal combustion engine with one or more cylinders, wherein at least one cylinder comprises a stand-alone ring-shaped impeller , wherein the at least one cylinder comprises at least two annular valves positioned substantially concentric with the cylinder, wherein the stand-alone ring-shaped impeller is positioned rotatably between the two concentric annular valves , and wherein the at least one cylinder is covered by a cylinder head in which the annular valves are mounted.
A spa with built-in seating, comprising; a pool body partially enclosing a water cavity ; and a seating assembly including an inflatable bench attached to a floor of the pool body , and an inflatable backrest detachably coupled to the inflatable bench by at least one attachment assembly having an adjustable length such that a user can adjust a position of the inflatable backrest relative to the inflatable bench wherein the attachment assembly comprises: a loop attached to the inflatable bench ; a belt comprising a first end portion, a middle portion, and a second end portion; a reception part of a buckle attached to a first end of the first end portion; a point of connection attaching a second end of the first end portion and a first end of the middle portion to the inflatable backrest; and an insertion part having slot through which the middle portion enters and the end portion emerges, the slot providing friction against slippage of the belt through the insertion part, wherein: the insertion part and the middle portion are passed through the loop and the insertion part is inserted into the reception part to fasten the attachment assembly, and a length of the second end portion can be pulled through the slot to shorten a length of the attachment assembly. a pool body partially enclosing a water cavity ; and a seating assembly including an inflatable bench attached to a floor of the pool body , and an inflatable backrest detachably coupled to the inflatable bench by at least one attachment assembly having an adjustable length such that a user can adjust a position of the inflatable backrest relative to the inflatable bench wherein the attachment assembly comprises: a seating assembly including an inflatable bench attached to a floor of the pool body , and an inflatable backrest detachably coupled to the inflatable bench by at least one attachment assembly having an adjustable length such that a user can adjust a position of the inflatable backrest relative to the inflatable bench wherein the attachment assembly comprises: a loop attached to the inflatable bench ; a belt comprising a first end portion, a middle portion, and a second end portion; a reception part of a buckle attached to a first end of the first end portion; a point of connection attaching a second end of the first end portion and a first end of the middle portion to the inflatable backrest; and an insertion part having slot through which the middle portion enters and the end portion emerges, the slot providing friction against slippage of the belt through the insertion part, wherein: the insertion part and the middle portion are passed through the loop and the insertion part is inserted into the reception part to fasten the attachment assembly, and a length of the second end portion can be pulled through the slot to shorten a length of the attachment assembly.
Tank of a space vehicle, which comprises a device for the generation of a force acting on a propellant contained in the tank, which device comprises a magnetic device for the generation of an external magnetic field, and thereby for the induction of a magnetic moment in the propellant, wherein the magnetic device has at least two elements (220, 220a, 220b, 230, 230a, 230b, 240, 240', 240", 310, 310', 320, 320', 330', 330"), which can be moved relative to one another so as to adjust the external magnetic field.
An apparatus, comprising: an electrochromic device comprising at least two separate conductive layers (204, 206; 310; 410; 510; 604, 606; 704, 706; 804, 806), on opposite sides of an electrochromic (EC) film stack ; characterized in that : the electrochromic device is structured to selectively heat a particular limited region of at least one conductive layer, of the at least two separate conductive layers, relative to a remainder region (212, 314, 414A-B, 417A-B, 517A-B, 612, 616, 762) of the at least one conductive layer.
A bearing pad comprising: - an internal cooling opening defined in the bearing pad ; and - an internal channel network defined in the bearing pad comprising at least one channel node in fluid communication with the internal cooling opening and at least two passageways in fluid communication with and extending from the channel node through the bearing pad , wherein at least one of the passageways extends to an exterior surface of the bearing pad to define at least one cooling discharge opening , characterized in that channel support structures are located within the internal channel network . - an internal cooling opening defined in the bearing pad ; and - an internal channel network defined in the bearing pad comprising at least one channel node in fluid communication with the internal cooling opening and at least two passageways in fluid communication with and extending from the channel node through the bearing pad ,
An elevator rope comprising a steel cord and an elastomer jacket surrounding said steel cord, said elevator rope having a substantially circular cross section, characterized in that said elevator rope further comprises one or more yarns (120, 122; 220, 220', 222, 222'; 320, 322, 324), wrapped, braided or knitted around said steel cord, said one or more yarns being integral with said elastomer jacket wherein said yarn is made of synthetic material selected from the group consisting of glass fibres, poly-aramide fibres, poly(p-phenylene-2,6-benzobisoxazole) fibres, polyurethane fibres, carbon fibres, polyolefin fibres, polyamide fibres, polyester fibres, poly ethylene terephthalate fibres, polycarbonate fibres, polyacetal fibres, polysulfone fibres, poly phenylene sulphide, polyether ketone fibres , polyimide fibres, polyether imide fibres or mixtures thereof or wherein said yarn is natural or semi-synthetic fibre selected from the group consisting of sisal, flax, cotton, hemp, silk, basalt, cellulose based fibres, rayon or mixtures thereof. said elevator rope further comprises one or more yarns (120, 122; 220, 220', 222, 222'; 320, 322, 324), wrapped, braided or knitted around said steel cord, said one or more yarns being integral with said elastomer jacket wherein said yarn is made of synthetic material selected from the group consisting of glass fibres, poly-aramide fibres, poly(p-phenylene-2,6-benzobisoxazole) fibres, polyurethane fibres, carbon fibres, polyolefin fibres, polyamide fibres, polyester fibres, poly ethylene terephthalate fibres, polycarbonate fibres, polyacetal fibres, polysulfone fibres, poly phenylene sulphide, polyether ketone fibres , polyimide fibres, polyether imide fibres or mixtures thereof or wherein said yarn is natural or semi-synthetic fibre selected from the group consisting of sisal, flax, cotton, hemp, silk, basalt, cellulose based fibres, rayon or mixtures thereof.
An RNA-modulating agent comprising an mRNA binding sequence that is complementary to a portion of a target mRNA sequence, linked to two or more miRNA binding sequences, wherein one or more of the miRNA binding sequences are complementary to at least positions 2 to 8 of an miRNA, but not complementary to positions 10 and 11 of the miRNA, wherein the RNA-modulating agent inhibits or silences a mRNA to which it binds.
An anti-proprotein convertase subtilisin/kexin type 9 (anti-PCSK9) antibody or antigen-binding fragment thereof for use in treating a subject with primary hypercholesterolemia who is statin intolerant or statin uncontrolled, wherein the antibody or antigen-binding fragment thereof is administered at a dose of 150 mg every 4 weeks for at least 3 doses in the absence of a concomitant statin therapy, thereby reducing low-density lipoprotein cholesterol (LDL-C) in the subject and wherein the antibody or antigen-binding fragment thereof comprises six heavy and light chain complementarity determining regions HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, LCDR3 amino acid sequences having SEQ ID NOs: 2, 3, 4, 7, 8, and 10, respectively.
A syringe assembly , comprising: an assembly housing ; a first syringe disposed within the assembly housing, the first syringe comprising: a first syringe body defining a first syringe cavity and a first syringe port , wherein the first syringe port is in fluid communication with the first syringe cavity; and a first plunger movable within the first syringe cavity and defining a first chamber in the first syringe cavity, wherein the first chamber is in fluid communication with the first syringe port, the first plunger comprising a first gear rack extending longitudinally along the first plunger; a second syringe disposed within the assembly housing, the second syringe comprising: a second syringe body defining a second syringe cavity and a second syringe port , wherein the second syringe port is in fluid communication with the second syringe cavity; and a second plunger movable within the second syringe cavity and defining a second chamber in the second syringe cavity, wherein the second chamber is in fluid communication with the second syringe port, the second plunger comprising a second gear rack extending longitudinally along the second plunger; a connecting gear rotatably coupled to the assembly housing, wherein the connecting gear is configured to be in meshed engagement with at least one of the first gear rack and the second gear rack; and characterized by : a pusher assembly moveable within the assembly housing, the pusher assembly comprising: a main pusher shaft extending from outside of the assembly housing to inside the assembly housing; and an intermediate pusher shaft releasably coupled to the main pusher shaft, wherein the intermediate pusher shaft is configured to engage with and advance the first plunger. a main pusher shaft extending from outside of the assembly housing to inside the assembly housing; and an intermediate pusher shaft releasably coupled to the main pusher shaft, wherein the intermediate pusher shaft is configured to engage with and advance the first plunger.
A wire tension control device , comprising: a bobbin configured to provide a wire ; and a magnetic moment generator , comprising a stator , a rotor relatively rotatable with respect to the stator , and a transmission shaft , wherein the rotor is connected to the bobbin , and the magnetic moment generator is configured to generate a tension on the wire when the bobbin drives the rotor to rotate; a course adjustment element connected to the stator and configured to adjust the position of the stator along an extension direction (S1) of the transmission shaft ; and a base having an outer screw ; and wherein the position of the stator is adjustable, and wherein the course adjustment element has an inner screw , and the inner screw and the outer screw are relatively ratable to be engaged with each other; characterised in that the wire tension control device further comprises an anti-loose element located between the base and the course adjustment element , wherein said anti-loose element is a spring. a bobbin configured to provide a wire ; and a magnetic moment generator , comprising a stator , a rotor relatively rotatable with respect to the stator , and a transmission shaft , wherein the rotor is connected to the bobbin , and the magnetic moment generator is configured to generate a tension on the wire when the bobbin drives the rotor to rotate; a course adjustment element connected to the stator and configured to adjust the position of the stator along an extension direction (S1) of the transmission shaft ; and a base having an outer screw ; and wherein the position of the stator is adjustable, and wherein the course adjustment element has an inner screw , and the inner screw and the outer screw are relatively ratable to be engaged with each other; characterised in that the wire tension control device further comprises an anti-loose element located between the base and the course adjustment element , wherein said anti-loose element is a spring.
A case for motorcycles, which comprises a base and a lid that define an inner housing , the case also comprising a lock for locking the lid and the base together, preventing access to the inner housing , the case further comprising an extension that pivots about a longitudinal axis (X) of said lock , between at least a first and a second position, said second position defining a volume of the inner housing greater than the volume of the inner housing when the extension is in said first position, wherein the case further comprises a latch for unlocking the extension and moving it between said first and second positions, or vice versa, characterized by said extension comprising a protrusion that slides inside a groove , and said latch comprising one or more housings complementary to said protrusion , such that the extension can be locked in the first and second positions, and at least in one intermediate position.