mhurhangee/patent-ind-claim-en huggingface dataset:
A method of identifying a test compound that induces a cereblon (CRBN) conformational change or otherwise alters the properties of a CRBN surface, comprising (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound that induces a CRBN conformational change or alteration; and wherein said conformational change or alteration has an effect on W380, W386 and/or W400 of CRBN; has an effect on E377 of CRBN; or has an effect on V388 of CRBN. (a) (i) obtaining a first crystal structure of CRBN and a reference compound, and (ii) determining a three-dimensional structure of the first crystal by x-ray diffraction to obtain a first set of atomic coordinates; (b) (i) obtaining a second crystal comprising CRBN and the test compound, and (ii) determining a three-dimensional structure of the second crystal by x-ray diffraction to obtain a second set of atomic coordinates; and (c) comparing said first set of atomic coordinates with said second set of atomic coordinates; wherein a difference in atomic coordinates is indicative of a compound that induces a CRBN conformational change or alteration; and wherein said conformational change or alteration has an effect on W380, W386 and/or W400 of CRBN; has an effect on E377 of CRBN; or has an effect on V388 of CRBN.
Process for preparing nitric acid by first vaporizing ammonia in at least one first ammonia vaporizer to produce an ammonia gas, oxidizing this ammonia gas to nitrogen dioxide in a plant section of the nitric acid plant and thereafter absorbing the nitrogen dioxide in water to produce nitric acid, with a residual gas containing nitrous gases being taken off from the plant section of the nitric acid plant and conveyed to a residual-gas cleaning apparatus , and the residual gas containing nitrous gases being reduced by means of ammonia in the residual-gas cleaning apparatus , characterized in that ammonia-containing wastewater obtained in the at least one first ammonia vaporizer or otherwise is conveyed to the residual-gas cleaning apparatus .
Removable die of a joining tool , in particular of a setting device, comprising a die head having an upper side and a bottom side as well as a die shaft extending perpendicularly from the bottom side of the die head and being adapted to be receivable and lockable in a die dome without rotation, wherein the die shaft comprises: a. at least one first radial web forming an axial undercut with a side facing the die head by means of which the die shaft is solely lockable in the die dome by means of a linear inserting movement, b. at least one second radial web , the radial length of which is dadapted to a diameter of the die dome to ensure a lateral guiding of the die shaft in the die dome and which is arranged between the die head and the first radial web , and c. an ejection surface by means of which the removable die can be moved out of the die dome and which is arranged adjacent to the free end of the die shaft opposite to the die head , characterized in that d. the at least one first radial web forms an axial undercut with a side facing away from the die head , and e. the removable die comprises a die shaft axially extending beyond the first radial web . a. at least one first radial web forming an axial undercut with a side facing the die head by means of which the die shaft is solely lockable in the die dome by means of a linear inserting movement, b. at least one second radial web , the radial length of which is dadapted to a diameter of the die dome to ensure a lateral guiding of the die shaft in the die dome and which is arranged between the die head and the first radial web , and c. an ejection surface by means of which the removable die can be moved out of the die dome and which is arranged adjacent to the free end of the die shaft opposite to the die head , characterized in that d. the at least one first radial web forms an axial undercut with a side facing away from the die head , and e. the removable die comprises a die shaft axially extending beyond the first radial web .
Piece of furniture with a one-part or multi-part door , which serves the closing of an opening of the piece of furniture and which is connected by hinges with an mounting profile , which is held displaceable within a door compartment by a displacement device between a first and a second end position, which displacement device comprises a lever mechanism , which includes four lever units rotatable in a plane, a first connecting bar and a second connecting bar and a centre bar , which centre bar is pivotally connected on a first side by a first lever unit and a second lever unit , which are spaced apart and aligned parallel to each other, to the first connecting bar , which is connected to at least one holding device mounted on the piece of furniture , and which centre bar is pivotally connected on a second side by a third lever unit and a fourth lever unit , which are spaced apart and aligned parallel to each other, to the second connecting bar , which is connected to the mounting profile , wherein in the first end position of the mounting profile the lever units (51, 53; 52, 54) are aligned at least approximately parallel to the first and second connecting bar and are at least partially countersunk into the centre bar , which centre bar in that first end position of the mounting profile is at least partially countersunk into at least one of the first connecting bars . which displacement device comprises a lever mechanism , which includes four lever units rotatable in a plane, a first connecting bar and a second connecting bar and a centre bar , which centre bar is pivotally connected on a first side by a first lever unit and a second lever unit , which are spaced apart and aligned parallel to each other, to the first connecting bar , which is connected to at least one holding device mounted on the piece of furniture , and which centre bar is pivotally connected on a second side by a third lever unit and a fourth lever unit , which are spaced apart and aligned parallel to each other, to the second connecting bar , which is connected to the mounting profile , wherein in the first end position of the mounting profile the lever units (51, 53; 52, 54) are aligned at least approximately parallel to the first and second connecting bar and are at least partially countersunk into the centre bar , which centre bar in that first end position of the mounting profile is at least partially countersunk into at least one of the first connecting bars .
A compression molding process for preparing an orodispersible tablet having a hardness ranging from 30 to 80 N, preferably from 40 to 75 N, a friability of less than 1% and preferably less than 0.5%, a disintegration in the mouth of less than 60 seconds and preferably less than 40 seconds, characterized in that said process comprises the following steps: - preparation of a mixture of excipients, said mixture of excipients being in the form of grains, said mixture of excipients being chosen from the group comprising a diluent, a disintegrant, a sweetener, a binder, a flow agent, a humectant or wetting agent, a lubricant, a flavoring agent, a colorant and mixtures thereof, - wetting said mixture of excipients by using a wetting solution in an amount making it possible to obtain a wet mixture of excipients having a residual humidity or water content ranging from 2% to 4%, - preparation of coated microcrystals or microgranules of active principle, - mixing of the coated microcrystals or microgranules of active principle, on the one hand, and of the wet mixture of excipients in the form of grains, on the other hand, in order to obtain a wet mixture for compression having a residual humidity or water content ranging from 2% to 3%, - optionally, adding to the wet mixture for compression, as prepared above, of excipients chosen from the group comprising a flow agent, a lubricant, a flavoring, a sweetener and mixtures thereof, - compression of the mixture for compression prepared above to obtain a tablet, - optionally, drying of the tablet thus obtained. - preparation of a mixture of excipients, said mixture of excipients being in the form of grains, said mixture of excipients being chosen from the group comprising a diluent, a disintegrant, a sweetener, a binder, a flow agent, a humectant or wetting agent, a lubricant, a flavoring agent, a colorant and mixtures thereof, - wetting said mixture of excipients by using a wetting solution in an amount making it possible to obtain a wet mixture of excipients having a residual humidity or water content ranging from 2% to 4%, - preparation of coated microcrystals or microgranules of active principle, - mixing of the coated microcrystals or microgranules of active principle, on the one hand, and of the wet mixture of excipients in the form of grains, on the other hand, in order to obtain a wet mixture for compression having a residual humidity or water content ranging from 2% to 3%, - optionally, adding to the wet mixture for compression, as prepared above, of excipients chosen from the group comprising a flow agent, a lubricant, a flavoring, a sweetener and mixtures thereof, - compression of the mixture for compression prepared above to obtain a tablet, - optionally, drying of the tablet thus obtained.
A method for managing base station, BS , communications in a wireless communications system, comprising: deciding, at the base station, BS , to locate control information at one or more resource element positions in a control channel region of a downlink subframe or a slot of the downlink subframe, wherein at least the control channel region is multiplexed, within at least one symbol, with a legacy control region; adjusting, at the base station, BS , a position of the data channel region and a transmission time interval, TTI, length of the data channel region, as being less than a temporal length of the downlink subframe, based on the control information; transmitting, to a user equipment, UE , the control information located at the one or more resource element positions in the control channel region of the downlink subframe or the slot of the downlink subframe; and transmitting, to the UE , at the adjusted position, downlink data in the data channel region. deciding, at the base station, BS , to locate control information at one or more resource element positions in a control channel region of a downlink subframe or a slot of the downlink subframe, wherein at least the control channel region is multiplexed, within at least one symbol, with a legacy control region; adjusting, at the base station, BS , a position of the data channel region and a transmission time interval, TTI, length of the data channel region, as being less than a temporal length of the downlink subframe, based on the control information; transmitting, to a user equipment, UE , the control information located at the one or more resource element positions in the control channel region of the downlink subframe or the slot of the downlink subframe; and transmitting, to the UE , at the adjusted position, downlink data in the data channel region.
A method of setting the working parameters of a construction machine when repairing a road surface, in particular by milling or paving a structural layer, wherein the construction machine is provided with a control device of its working tool and a communication port, characterized in that during a milling or paving pass that precedes a pass where cross slopes are replicated, cross slope values and position data from a construction machine positioning system are automatically stored in a database, and during a working pass where cross slopes are required to be identical to, or functionally dependent on, the cross slopes of at least one previous pass, positional data are received to determine a position of a working tool in real time and the required cross slope is determined from the recorded cross slopes in the database, that have been recorded in at least one previous pass at a stationing corresponding to a stationing of the current position of the construction machine, wherein the determined data is transmitted to the construction machine for setting the working tool by at least one method selected from the group consisting of manual input, automatic transmission to the construction machine control device, and automatic transmission to a construction machine communication port.
A system configured to generate a plurality of high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals , the system comprising: - means for receiving a bitstream comprising an encoded low frequency signal and control data indicative of whether to apply a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals , respectively, to generate the plurality of high frequency subband signals ; - means for decoding the encoded low frequency signal to obtain a decoded low frequency signal; - means for converting the decoded low frequency signal into the plurality of low frequency subband signals; - means for receiving a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval ; - means for generating the plurality of high frequency subband signals from the plurality of low frequency subband signals , wherein, when the control data indicates to apply the spectral gain coefficients, generating the plurality of high frequency subband signals comprises applying, to the plurality of low frequency subband signals , the plurality of spectral gain coefficients associated with the plurality of low frequency subband signals , respectively; and - means for adjusting the energy of the plurality of high frequency subband signals using the set of target energies. - means for receiving a bitstream comprising an encoded low frequency signal and control data indicative of whether to apply a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals , respectively, to generate the plurality of high frequency subband signals ; - means for decoding the encoded low frequency signal to obtain a decoded low frequency signal; - means for converting the decoded low frequency signal into the plurality of low frequency subband signals; - means for receiving a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval ; - means for generating the plurality of high frequency subband signals from the plurality of low frequency subband signals , wherein, when the control data indicates to apply the spectral gain coefficients, generating the plurality of high frequency subband signals comprises applying, to the plurality of low frequency subband signals , the plurality of spectral gain coefficients associated with the plurality of low frequency subband signals , respectively; and - means for adjusting the energy of the plurality of high frequency subband signals using the set of target energies.
A variant of recombinant human DKK3b protein comprising: (i) amino acids 1-20 of the N-terminus of human DKK3b; (ii) the 50 amino acid long N1 cysteine rich domain of human DKK3b; and (iii) the C-terminus 20 amino acids of human DKK3b; wherein the variant is an inhibitor of β-catenin signaling; and wherein the variant does not comprise one or more of the amino acid sequences of human DKK3b selected from the group consisting of: amino acids 21-71 and amino acids 125-260. (i) amino acids 1-20 of the N-terminus of human DKK3b; (ii) the 50 amino acid long N1 cysteine rich domain of human DKK3b; and (iii) the C-terminus 20 amino acids of human DKK3b;
A semiconductor structure, the semiconductor structure comprises: a substrate having a power supply port ; a memory module positioned on an upper surface of the substrate , the memory module comprising a plurality of memory chips stacked in a first direction (X), the first direction (X) being parallel to the upper surface of the substrate , each of the plurality of memory chips having a power supply signal line , at least one of the plurality of memory chips having a power supply wiring layer , the power supply signal line being electrically connected to the power supply wiring layer , the power supply wiring layer being positioned in the memory module , an end surface of the power supply wiring layer far away from the substrate being exposed by the memory module , a solder bump being further provided on the end surface ; and a lead frame electrically connected to the solder bump and the power supply port , wherein the lead frame comprises a plurality of frame strips arranged at intervals, and the plurality of frame strips being arranged in a second direction (Y); the second direction (Y) is perpendicular to the first direction (X) and is parallel to the upper surface of the substrate ; each of the power supply wiring layers comprises a plurality of power supply wirings , and different power supply wirings having different voltages; and different frame strips are connected to the power supply wirings having the different voltages. a substrate having a power supply port ; a memory module positioned on an upper surface of the substrate , the memory module comprising a plurality of memory chips stacked in a first direction (X), the first direction (X) being parallel to the upper surface of the substrate , each of the plurality of memory chips having a power supply signal line , at least one of the plurality of memory chips having a power supply wiring layer , the power supply signal line being electrically connected to the power supply wiring layer , the power supply wiring layer being positioned in the memory module , an end surface of the power supply wiring layer far away from the substrate being exposed by the memory module , a solder bump being further provided on the end surface ; and a lead frame electrically connected to the solder bump and the power supply port , wherein the lead frame comprises a plurality of frame strips arranged at intervals, and the plurality of frame strips being arranged in a second direction (Y); the second direction (Y) is perpendicular to the first direction (X) and is parallel to the upper surface of the substrate ; each of the power supply wiring layers comprises a plurality of power supply wirings , and different power supply wirings having different voltages; and different frame strips are connected to the power supply wirings having the different voltages.
A power cabling connection for supplying power from a power supply to a plurality of remote radio heads (150-1, 150-2, 150-3), comprising: a trunk power cable having a trunk power supply conductor and a trunk return conductor that are enclosed within a cable jacket and electrically insulated from each other; a plurality of remotely-controlled power supply switches interposed between the trunk power cable and the respective remote radio heads (150-1, 150-2, 150-3) that are configured to selectively electrically connect the trunk power supply conductor and the trunk return conductor to a respective one of the remote radio heads (150-1, 150-2, 150-3); wherein the power supply switches are included in respective jumper cables (137', 137"), each including a respective power supply conductor and a respective return conductor and each jumper cable being connected between the trunk power cable and one of the plurality of remote radio heads (150-1, 150-2, 150-3) or the power supply switches are included in inline devices , including in each inline device a pair of connectors and each being connected between each respective one of the plurality of jumper cables and each respective one of the remote radio heads (150-1, 150-2, 150-3). a trunk power cable having a trunk power supply conductor and a trunk return conductor that are enclosed within a cable jacket and electrically insulated from each other; a plurality of remotely-controlled power supply switches interposed between the trunk power cable and the respective remote radio heads (150-1, 150-2, 150-3) that are configured to selectively electrically connect the trunk power supply conductor and the trunk return conductor to a respective one of the remote radio heads (150-1, 150-2, 150-3); wherein the power supply switches are included in respective jumper cables (137', 137"), each including a respective power supply conductor and a respective return conductor and each jumper cable being connected between the trunk power cable and one of the plurality of remote radio heads (150-1, 150-2, 150-3) or the power supply switches are included in inline devices , including in each inline device a pair of connectors and each being connected between each respective one of the plurality of jumper cables and each respective one of the remote radio heads (150-1, 150-2, 150-3).
A photovoltaic module (PM) comprising a plurality of photovoltaic cells , each of the cells comprising a cell body including a semiconductor body with a photosensitive region for photogeneration of charge carriers in response to absorption of electromagnetic radiation; wherein - the cell body includes an electrically conductive front side surface layer that is arranged on the semiconductor body and forms a front surface of the cell body and that is transparent for the impinging electromagnetic radiation used for the photogeneration of the charge carriers, and an electrically conductive back side surface layer that is arranged on the semiconductor body and forms a back surface of the cell body ; - the cells are electrically connected with each other via a plurality of electrically conductive wires configured for providing a voltage to an external electrical load in operation of the module; - the individual wires have a convex outer surface in directions perpendicular to their respective longitudinal wire extension and include a metal core and an electrically conductive and adhesive wire coat that is directly attached and in immediate electrical contact to the front side surface layer or the backside surface layer of a given cell body by means of an electrically conductive adhesive bond. - the cell body includes an electrically conductive front side surface layer that is arranged on the semiconductor body and forms a front surface of the cell body and that is transparent for the impinging electromagnetic radiation used for the photogeneration of the charge carriers, and an electrically conductive back side surface layer that is arranged on the semiconductor body and forms a back surface of the cell body ; - the cells are electrically connected with each other via a plurality of electrically conductive wires configured for providing a voltage to an external electrical load in operation of the module; - the individual wires have a convex outer surface in directions perpendicular to their respective longitudinal wire extension and include a metal core and an electrically conductive and adhesive wire coat that is directly attached and in immediate electrical contact to the front side surface layer or the backside surface layer of a given cell body by means of an electrically conductive adhesive bond.