A system configured to control light exposure for circadian phase management and/or light deficient disorders of a subject, the system comprising: a user interface ; one or more physiological sensors configured to generate output signals conveying physiological data of the subject, wherein the one or more physiological sensors comprise a pupillometry sensor; a light control valve configured to block or reduce blue light ambient radiation reaching eyes of the subject; one or more radiation generators configured to generate therapeutic light radiation onto the eyes of the subject; and one or more processors in communication with the user interface, the one or more physiological sensors, the light control valve , and the one or more radiation generators, the one or more processors causing the system to: receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan . a user interface ; one or more physiological sensors configured to generate output signals conveying physiological data of the subject, wherein the one or more physiological sensors comprise a pupillometry sensor; a light control valve configured to block or reduce blue light ambient radiation reaching eyes of the subject; one or more radiation generators configured to generate therapeutic light radiation onto the eyes of the subject; and one or more processors in communication with the user interface, the one or more physiological sensors, the light control valve , and the one or more radiation generators, the one or more processors causing the system to: receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan . receive, via the user interface, physiological goals of the subject; utilize the pupillometry sensor to determine blink data of the subject and gaze detection; utilize the blink data and gaze detection for determining a fatigue/alertness level of the subject; determine a light control plan for the subject based on the physiological goals of the subject, the physiological data, environmental data, and time data, wherein the physiological data comprises the fatigue/alertness level; operate the light control valve to block or reduce blue light ambient radiation based on the light control plan; and generate, using the one or more radiation generators, therapeutic light radiation based on the light control plan . <EOS>