mhurhangee/patent-ind-claim-en huggingface dataset:
A conjugate of formula (I) S-L-A (I) or a pharmaceutically acceptable salt thereof, wherein A is a γ-secretase inhibitor of formula (A2) wherein X is -CR 4 R 4' - or - CR 4 R 4' -O-; R is halogen, C 1-7 alkyl or C 1-7 alkyl substituted by halogen; R 2 is hydrogen, C 1-7 alkyl, C 1-7 alkyl substituted by halogen or hydroxy, or is benzyl or C 3-8 cycloalkyl; R 3 is C 1-7 alkyl, C 1-7 alkyl substituted by halogen, is benzyl, benzyl substituted by two halogen, is -(CH 2 ) m -C 3-8 cycloalkyl or -(CH 2 ) m -pyridinyl; R 4 and R 4' are independently from each other hydrogen, halogen, C 1-7 alkyl, C 1-7 alkyl substituted by hydroxy, C 1-7 alkoxy, or hydroxy; n is 0, 1 or 2; m is 0, 1 or 2; L is a cleavable linker of formula (L1) wherein Y is void, O or NH; R 5 is hydrogen, halogen, C 1-7 alkyl, or C 1-7 alkoxy; q is 1, 2, 3 or 4; and S is a peptidase-specific substrate of formula (S1) wherein R 6 is hydrogen, C 1-7 alkyl, -NH 2 or -NH-C(O)-C 1-7 alkyl; each R 7 is independently selected from hydrogen, halogen, C 1-7 alkyl, or C 1-7 alkoxy; R 8 is hydrogen, C 1-7 alkyl, -NH 2 or -NH-C(O)-C 1-7 alkyl; r is 0, 1, 2 or 3; with the proviso that at least one of R 6 or R 8 is -NH 2 or -NH-C(O)-C 1-7 alkyl. X is -CR 4 R 4' - or - CR 4 R 4' -O-; R is halogen, C 1-7 alkyl or C 1-7 alkyl substituted by halogen; R 2 is hydrogen, C 1-7 alkyl, C 1-7 alkyl substituted by halogen or hydroxy, or is benzyl or C 3-8 cycloalkyl; R 3 is C 1-7 alkyl, C 1-7 alkyl substituted by halogen, is benzyl, benzyl substituted by two halogen, is -(CH 2 ) m -C 3-8 cycloalkyl or -(CH 2 ) m -pyridinyl; R 4 and R 4' are independently from each other hydrogen, halogen, C 1-7 alkyl, C 1-7 alkyl substituted by hydroxy, C 1-7 alkoxy, or hydroxy; n is 0, 1 or 2; m is 0, 1 or 2; L is a cleavable linker of formula (L1) Y is void, O or NH; R 5 is hydrogen, halogen, C 1-7 alkyl, or C 1-7 alkoxy; q is 1, 2, 3 or 4; and S is a peptidase-specific substrate of formula (S1) R 6 is hydrogen, C 1-7 alkyl, -NH 2 or -NH-C(O)-C 1-7 alkyl; each R 7 is independently selected from hydrogen, halogen, C 1-7 alkyl, or C 1-7 alkoxy; R 8 is hydrogen, C 1-7 alkyl, -NH 2 or -NH-C(O)-C 1-7 alkyl; r is 0, 1, 2 or 3;
A method comprising: selecting an acoustic arrangement that specifies one or more acoustic parameters for one or more acoustic categories, the acoustic parameters of the selected acoustic arrangement being implementable by an acoustic control system of a vehicle, wherein the selected acoustic arrangement further includes at least one acoustic configuration, the at least one acoustic configuration having one or more acoustic parameters that are configured to adjust the applied one or more acoustic parameters of the one or more acoustic categories, wherein the at least one acoustic configuration includes a geo-fencing acoustic configuration which is configured to adjust the one or more acoustic parameters including a volume setting based on a proximity of the vehicle to other vehicles; transmitting, via a telematics network , the one or more acoustic parameters of the selected acoustic arrangement to the acoustic control system ; receiving, by the acoustic control system , the transmitted one or more acoustic parameters; applying, by the acoustic control system , the received one or more acoustic parameters to control one or more characteristics of an audio for the one or more acoustic categories that is emitted from one or more speakers of the vehicle, whereby the geo-fencing acoustic configuration adjusts the applied one or more acoustic parameters based on a proximity of the vehicle to other vehicles. selecting an acoustic arrangement that specifies one or more acoustic parameters for one or more acoustic categories, the acoustic parameters of the selected acoustic arrangement being implementable by an acoustic control system of a vehicle, wherein the selected acoustic arrangement further includes at least one acoustic configuration, the at least one acoustic configuration having one or more acoustic parameters that are configured to adjust the applied one or more acoustic parameters of the one or more acoustic categories, wherein the at least one acoustic configuration includes a geo-fencing acoustic configuration which is configured to adjust the one or more acoustic parameters including a volume setting based on a proximity of the vehicle to other vehicles; transmitting, via a telematics network , the one or more acoustic parameters of the selected acoustic arrangement to the acoustic control system ; receiving, by the acoustic control system , the transmitted one or more acoustic parameters; applying, by the acoustic control system , the received one or more acoustic parameters to control one or more characteristics of an audio for the one or more acoustic categories that is emitted from one or more speakers of the vehicle, whereby the geo-fencing acoustic configuration adjusts the applied one or more acoustic parameters based on a proximity of the vehicle to other vehicles.
Use of a sealing element for structural waterproofing, wherein the sealing element is an adhesive planar structure which is sticky on both sides and the sealing element comprises a pressure-sensitive adhesive and a water-swellable component and the proportion of the water-swellable component in the sealing element is between 2 wt.% and 50 wt.% and the adhesive planar structure is a polymer comprising acrylates, tackifiers and the water-swellable component.
A method of packaging an object, comprising: forming a package of heat-shrinkable film around an object , the heat-shrinkable film including a weakened portion ; coupling a protective film to the heat-shrinkable film , wherein the protective film is positioned to cover the weakened portion in the heat-shrinkable film ; and exposing the package of heat-shrinkable film and the protective film to a heat-shrink environment configured to cause the package of heat-shrinkable film to shrink and form a package of heat-shrunk film around the object ; wherein the protective film is positioned to cover the weakened portion in the heat-shrunk film after exposing the package of heat-shrinkable film and the protective film to the heat-shrink environment; characterized in that forming the package of heat-shrinkable film around the object comprises: feeding the heat-shrinkable film in a Z-folded state having a major fold and a minor fold , and forming a longitudinal seal between a first end of the heat-shrinkable film and the minor fold to form a tunnel of the heat-shrinkable film ; wherein the protective film is formed from the heat-shrinkable film between the minor fold and a second end of the heat-shrinkable film . forming a package of heat-shrinkable film around an object , the heat-shrinkable film including a weakened portion ; coupling a protective film to the heat-shrinkable film , wherein the protective film is positioned to cover the weakened portion in the heat-shrinkable film ; and exposing the package of heat-shrinkable film and the protective film to a heat-shrink environment configured to cause the package of heat-shrinkable film to shrink and form a package of heat-shrunk film around the object ; wherein the protective film is positioned to cover the weakened portion in the heat-shrunk film after exposing the package of heat-shrinkable film and the protective film to the heat-shrink environment; characterized in that forming the package of heat-shrinkable film around the object comprises: feeding the heat-shrinkable film in a Z-folded state having a major fold and a minor fold , and forming a longitudinal seal between a first end of the heat-shrinkable film and the minor fold to form a tunnel of the heat-shrinkable film ; feeding the heat-shrinkable film in a Z-folded state having a major fold and a minor fold , and forming a longitudinal seal between a first end of the heat-shrinkable film and the minor fold to form a tunnel of the heat-shrinkable film ; wherein the protective film is formed from the heat-shrinkable film between the minor fold and a second end of the heat-shrinkable film .
A bus bar comprising: a wiring pathway made from a conductive material and having bent portions bending at at least two sites of the wiring pathway , wherein, the wiring pathway comprises members consecutively arranged to form a plate shape, the members adjacent to each other are laser joined members, characterized in that the members include: connection members arranged at both ends of the wiring pathway and having connection portions for electrical input-output; and a conductive member arranged between the connection members , the conductive member is made from a material softer than the connection members , and the bent portions include: a bent portion formed by laser joining of one of the connection members and the conductive member ; and a bent portion formed in the conductive member . a wiring pathway made from a conductive material and having bent portions bending at at least two sites of the wiring pathway , wherein, the wiring pathway comprises members consecutively arranged to form a plate shape, the members adjacent to each other are laser joined members, characterized in that the members include: connection members arranged at both ends of the wiring pathway and having connection portions for electrical input-output; and a conductive member arranged between the connection members , connection members arranged at both ends of the wiring pathway and having connection portions for electrical input-output; and a conductive member arranged between the connection members , the conductive member is made from a material softer than the connection members , and
A method for generating a database , comprising the steps of: receiving environmental noises and buffering the environmental noises for a migrating time window or deriving a set of parameters from the environmental noises and buffering the set of parameters for the migrating time window in order to obtain a buffered recording; obtaining a signal which identifies a signal class from a plurality of signal classes in the environmental noise; storing the buffered recording, responsively to the signal, in a memory; and repeating the steps of obtaining and storing in order to obtain the database which comprises a plurality of buffered recordings for the same signal class; wherein the signal is received by user input means , a button or a smart device. receiving environmental noises and buffering the environmental noises for a migrating time window or deriving a set of parameters from the environmental noises and buffering the set of parameters for the migrating time window in order to obtain a buffered recording; obtaining a signal which identifies a signal class from a plurality of signal classes in the environmental noise; storing the buffered recording, responsively to the signal, in a memory; and repeating the steps of obtaining and storing in order to obtain the database which comprises a plurality of buffered recordings for the same signal class; wherein the signal is received by user input means , a button or a smart device.
A drip chamber comprising: a container configured to hold an IV fluid ; a drop former suspended over the container and coupled to an inlet port to receive the IV fluid from a reservoir; characterized in that the drip chamber further comprises an acoustic emitter operatively coupled to the drop former to stimulate a release of a drop of the IV fluid from the drop former . a container configured to hold an IV fluid ; a drop former suspended over the container and coupled to an inlet port to receive the IV fluid from a reservoir; characterized in that the drip chamber further comprises an acoustic emitter operatively coupled to the drop former to stimulate a release of a drop of the IV fluid from the drop former .
Vacuum cleaner comprising a suction pipe ; a waste separation device fluidically connected to the suction pipe ; a main body wherein is housed a suction device comprising an electric fan which is configured to generate an airflow through the suction pipe and the waste separation device ; a handle ; a control member which is disposed on the handle and which can be actuated by a user, the control member being configured to control an operation of the electric fan according to a first operating mode when the control member is actuated by a user; and an activation member which can be actuated by a user and which is configured to control an operation of the electric fan according to a second operating mode when the activation member is actuated by a user, the vacuum cleaner being configured such that a maximum rotation speed of the electric fan in the second operating mode is greater than a maximum rotation speed of the electric fan in the first operating mode, characterised in that the activation member is disposed facing the control member .
Pipe clip comprising a metal annular clip body having at least two opposing radial flanges defining an opening adapted to arrange the pipe clip body around a pipe , wherein the pipe clip body has at one of the radial flanges a female fastening means and wherein the pipe clip comprises a tightening screw having a screw head and a screw shank , said screw shank being provided with a male thread adapted to cooperate with the female fastening means, and wherein the screw head engages the other of the radial flanges so as to tighten the flanges towards each other and tighten the pipe clip around the pipe , and wherein the pipe clip has a vibration insulating lining provided on the inner side of the annular clip body , characterized in that a torque limiting cap is arranged on the screw head of the tightening screw , said torque limiting cap including at least one torque transferring feature that couples the cap to the screw head in a rotational direction.
An integrated laundry washer-dryer comprising a housing , a washing apparatus and a drying apparatus being arranged inside the housing and being configured to respectively independently operate, the drying apparatus comprises a heat exchange element and a heat exchange element filter device ; the washing apparatus comprises a water drainage path and a water drainage control device , the water drainage control device being arranged on the water drainage path and configured to control a connection and disconnection of the water drainage path; characterized in that : the water drainage path is in communication with the heat exchange element filter device ; the water drainage control device is configured to introduce the water drained from the washing apparatus to the heat exchange element filter device . a housing , a washing apparatus and a drying apparatus being arranged inside the housing and being configured to respectively independently operate, the drying apparatus comprises a heat exchange element and a heat exchange element filter device ; the washing apparatus comprises a water drainage path and a water drainage control device , the water drainage control device being arranged on the water drainage path and configured to control a connection and disconnection of the water drainage path; characterized in that : the water drainage path is in communication with the heat exchange element filter device ; the water drainage control device is configured to introduce the water drained from the washing apparatus to the heat exchange element filter device . the water drainage path is in communication with the heat exchange element filter device ; the water drainage control device is configured to introduce the water drained from the washing apparatus to the heat exchange element filter device .
Explosive charge (50; 250; 350) with a body containing explosive material , with at least one detonator cap which is connected to a detonator , wherein the detonator is connected to a pull element via a trigger cord , characterised in that at least one mechanical activating element is connected to the pulling element via an activating cord , and in that either in a first alternative in a standby position the at least one detonator is arranged spatially separated from the explosive , and in a triggering position the at least one detonator cap is positioned in a distance relative to the explosive material , and in a release position the at least one detonator cap by the mechanical activating element being moved via the activating cord relative towards the explosive material , or in a second alternative, when the detonator cap is a ripple detonator, in a standby position the at least one detonator cap is arranged spatially separated from a detonating cord leading to the explosive material , and in a release position the at least one detonator cap has been moved relative to the detonating cord leading to the explosive material by the mechanical activating element moved via the activating cord .
A method, comprising: at an electronic device with a display and a touch-sensitive surface: receiving , with a digital assistant, a natural-language speech input; determining a voice shortcut associated with the natural-language speech input, wherein the voice shortcut is a user-generated phrase customized by a user of the electronic device; determining a task corresponding to the voice shortcut; causing an application to initiate performance of the task, wherein the application is preloaded with one or more customized parameters associated with the voice shortcut, the one or more customized parameters defined by the user prior to receiving the speech input; receiving a response from the application, wherein the response is associated with the task; determining , based on the response, whether the task was successfully performed; and providing an output indicating whether the task was successfully performed. receiving , with a digital assistant, a natural-language speech input; determining a voice shortcut associated with the natural-language speech input, wherein the voice shortcut is a user-generated phrase customized by a user of the electronic device; determining a task corresponding to the voice shortcut; causing an application to initiate performance of the task, wherein the application is preloaded with one or more customized parameters associated with the voice shortcut, the one or more customized parameters defined by the user prior to receiving the speech input; receiving a response from the application, wherein the response is associated with the task; determining , based on the response, whether the task was successfully performed; and providing an output indicating whether the task was successfully performed.
An apparatus for joining two hollow organ sections with an annular array of surgical staples comprising: a staple cartridge assembly configured to support the annular array of surgical staples therein, the staple cartridge assembly including pushers configured to eject the respective surgical staples from the staple cartridge assembly , and an outer wall defining a cavity and having a finger deflectably extending over the cavity ; an anvil assembly movable relative to the staple cartridge assembly between spaced apart and approximated positions to adjustably clamp the two hollow organ sections between the staple cartridge and anvil assemblies ; and a buttress material including an annular body dimensioned to be mounted on a distal surface of the staple cartridge assembly , and a tab extending proximally from the annular body such that at least a portion of the tab is wrapped around the finger of the outer wall of the staple cartridge assembly , wherein the pushers are movable between a first position in which one of the pushers engages the finger such that the tab of the buttress material wrapped around the finger is secured against the pusher , and a second position in which the one of the pushers is disengaged from the finger such that the at least a portion of the tab of the buttress material wrapped around the finger is released from the one of the pushers . a staple cartridge assembly configured to support the annular array of surgical staples therein, the staple cartridge assembly including pushers configured to eject the respective surgical staples from the staple cartridge assembly , and an outer wall defining a cavity and having a finger deflectably extending over the cavity ; an anvil assembly movable relative to the staple cartridge assembly between spaced apart and approximated positions to adjustably clamp the two hollow organ sections between the staple cartridge and anvil assemblies ; and a buttress material including an annular body dimensioned to be mounted on a distal surface of the staple cartridge assembly , and a tab extending proximally from the annular body such that at least a portion of the tab is wrapped around the finger of the outer wall of the staple cartridge assembly , wherein the pushers are movable between a first position in which one of the pushers engages the finger such that the tab of the buttress material wrapped around the finger is secured against the pusher , and a second position in which the one of the pushers is disengaged from the finger such that the at least a portion of the tab of the buttress material wrapped around the finger is released from the one of the pushers .
A fluid pump comprising: a first inlet and a second inlet ; a first outlet comprising a first non-return valve , and a second outlet comprising a second non-return valve ; a chamber comprising a first passage extending between the first inlet and the first outlet , a second passage extending between the second inlet and the second outlet , and a cavity having a cylinder extending between the first and second passages ; a piston slidably disposed within the cylinder ; and a first Tesla valve in fluid communication with the first inlet , and a second Tesla valve in fluid communication with the second inlet ; wherein the fluid pump is configured to pump fluid from the first and the second inlets to the first and second outlets by reciprocation of the piston within the cylinder . a first inlet and a second inlet ; a first outlet comprising a first non-return valve , and a second outlet comprising a second non-return valve ; a chamber comprising a first passage extending between the first inlet and the first outlet , a second passage extending between the second inlet and the second outlet , and a cavity having a cylinder extending between the first and second passages ; a piston slidably disposed within the cylinder ; and a first Tesla valve in fluid communication with the first inlet , and a second Tesla valve in fluid communication with the second inlet ; wherein the fluid pump is configured to pump fluid from the first and the second inlets to the first and second outlets by reciprocation of the piston within the cylinder .
Planet carrier for a speed-reducing unit with an epicyclic gear train for a turbine engine, said planet carrier comprising a cage defining an internal space for mounting a central sun gear of rotation axis A and an annular row of planet gears arranged around the axis A and meshed with said sun gear, said sun gear comprising means for coupling to a first shaft, said cage comprising two parallel annular walls centred on said axis A and a cylindrical wall connecting said annular walls at their external periphery, a first of said annular walls being connected to a cylindrical body comprising means for coupling to a second shaft, characterised in that a second of said annular walls is formed of a single part with lubrication means which comprise an annular groove for receiving oil formed in said second wall and extending to the periphery of a central opening centred on the axis A of the second wall, said annular groove opening out radially inwards.