mhurhangee/patent-ind-claim-en huggingface dataset:
A method of determining the presence or absence of a target analyte in a sample, the method comprising: (a) immobilising any target analyte present in the sample on a surface; (b) contacting the surface with: (i) a first detection agent that binds specifically to the target analyte; and (ii) a reporter polynucleotide, wherein the reporter polynucleotide is bound to, or binds to, the first detection agent; and (c) contacting a transmembrane pore with any reporter polynucleotide immobilised on the surface by binding of the first detection agent to the target analyte, and using the transmembrane pore to detect the reporter polynucleotide, thereby determining the presence or absence of the target analyte in the sample. (a) immobilising any target analyte present in the sample on a surface; (b) contacting the surface with: (i) a first detection agent that binds specifically to the target analyte; and (ii) a reporter polynucleotide, wherein the reporter polynucleotide is bound to, or binds to, the first detection agent; and (c) contacting a transmembrane pore with any reporter polynucleotide immobilised on the surface by binding of the first detection agent to the target analyte, and using the transmembrane pore to detect the reporter polynucleotide, thereby determining the presence or absence of the target analyte in the sample.
A power conversion system to be used with an energy source, comprising: a plurality of conversion units , each comprising a pair of input terminals and a pair of output terminals, wherein the input terminals are connected in series with the energy source, wherein the positive input terminal of a first conversion unit and the negative input terminal of a last conversion unit of the series are for connection to an output of the energy source, and for each two neighboring conversion units in this series a negative input terminal pin of an upstream conversion unit is connected to a positive input terminal of a downstream conversion unit; a master monitor unit adapted to monitor the output power of the energy source; and a controller adapted to control the input voltage of each conversion unit synchronously in dependence on the monitored output power, characterized in that both input terminals of each of conversion unit are decoupled from the energy source except for the positive input terminal of the first conversion unit and the negative input terminal of the last conversion unit. a plurality of conversion units , each comprising a pair of input terminals and a pair of output terminals, wherein the input terminals are connected in series with the energy source, wherein the positive input terminal of a first conversion unit and the negative input terminal of a last conversion unit of the series are for connection to an output of the energy source, and for each two neighboring conversion units in this series a negative input terminal pin of an upstream conversion unit is connected to a positive input terminal of a downstream conversion unit; a master monitor unit adapted to monitor the output power of the energy source; and a controller adapted to control the input voltage of each conversion unit synchronously in dependence on the monitored output power, characterized in that both input terminals of each of conversion unit are decoupled from the energy source except for the positive input terminal of the first conversion unit and the negative input terminal of the last conversion unit.
An apparatus , comprising: (a) a body assembly comprising a handle portion ; (b) an end effector comprising a staple driver , wherein the staple driver is operable to actuate relative to the body assembly between an unfired position and a fired position; and (c) a trigger comprising a lever and a spring member , wherein the lever is pivotally coupled to the handle portion , wherein the trigger is configured to pivot between a first position and a second position to slidably actuate the staple driver , wherein the first position is associated with the staple driver in the unfired position, wherein the second position is associated with the staple driver in the fired position, wherein the spring member is housed within the body assembly , wherein the spring member is configured to resiliently bias the trigger relative to the body assembly toward the first position; characterized in that : the spring member is an integral spring member extending unitarily from the lever . (a) a body assembly comprising a handle portion ; (b) an end effector comprising a staple driver , wherein the staple driver is operable to actuate relative to the body assembly between an unfired position and a fired position; and (c) a trigger comprising a lever and a spring member , wherein the lever is pivotally coupled to the handle portion , wherein the trigger is configured to pivot between a first position and a second position to slidably actuate the staple driver , wherein the first position is associated with the staple driver in the unfired position, wherein the second position is associated with the staple driver in the fired position, wherein the spring member is housed within the body assembly , wherein the spring member is configured to resiliently bias the trigger relative to the body assembly toward the first position; characterized in that : the spring member is an integral spring member extending unitarily from the lever .
A wind power installation rotor blade which can be connected to a hub of the wind power installation by means of a rotary connection , wherein the rotary connection is in the form of a plain bearing assembly, comprising an inner ring (3, 3', 3") having a number of first plain bearing surfaces (11a, b, c), an outer ring (5, 5', 5") having a number of second plain bearing surfaces (13a, b, c) which are respectively associated with one of the first plain bearing surfaces as a plain bearing surface partner, wherein the inner ring and the outer ring each have a radial bearing surface and two axial bearing surfaces , and wherein the plain bearing assembly is in the form of a dry-running plain bearing assembly, characterized in that the outer ring has one, more or all of the number of plain bearing surfaces (13a-c) of fibre composite material, and is of an at least two-part structure insofar as the radial plain bearing surface and a first axial plain bearing surface are provided at a first body portion and the second axial plain bearing surfaces is provided at at least one second body portion , wherein the first body portion is provided integrally on the rotor blade . the rotary connection is in the form of a plain bearing assembly, comprising an inner ring (3, 3', 3") having a number of first plain bearing surfaces (11a, b, c), an outer ring (5, 5', 5") having a number of second plain bearing surfaces (13a, b, c) which are respectively associated with one of the first plain bearing surfaces as a plain bearing surface partner, wherein the inner ring and the outer ring each have a radial bearing surface and two axial bearing surfaces , and wherein the plain bearing assembly is in the form of a dry-running plain bearing assembly, characterized in that the outer ring has one, more or all of the number of plain bearing surfaces (13a-c) of fibre composite material, and is of an at least two-part structure insofar as the radial plain bearing surface and a first axial plain bearing surface are provided at a first body portion and the second axial plain bearing surfaces is provided at at least one second body portion , wherein the first body portion is provided integrally on the rotor blade .
A pad for orthopedic aids, comprising a pad base body made of a first material and at least one pad pressure element made of a second material, wherein the pad pressure element is at least partially embedded in the pad base body , and wherein the first material of the pad base body is softer than the second material of the pad pressure element , wherein the pad pressure element has at least two pin-shaped elevations and a base element , wherein the pin-shaped elevations are arranged on the base element , wherein the pin-shaped elevations are movable in a viscoelastic manner by way of the base element , wherein the base element has at least one hole and wherein the at least two pin-shaped elevations on the base element are positioned at the edge of the at least one hole characterized in that the at least two pin-shaped elevations are connected to one another by way of a web spanning the hole and a further pin-shaped elevation is arranged on the web .
A method of making a coated abrasive article , the method comprising sequentially: providing a backing having first and second opposed major surfaces , wherein a make layer precursor is disposed on at least a portion of the first major surface; disposing magnetizable abrasive particles onto the make layer precursor while under the influence of an applied magnetic field , such that at least a majority the magnetizable abrasive particles extend away from the make layer precursor in an orientation substantially aligned with the applied magnetic field ; the method being characterized in that it further comprises the steps of: disposing non-magnetizable particles onto the make layer precursor , wherein at least some of the non-magnetizable particles are disposed between the magnetizable abrasive particles while under the influence of the applied magnetic field ; and at least partially curing the make layer precursor to provide a make layer . providing a backing having first and second opposed major surfaces , wherein a make layer precursor is disposed on at least a portion of the first major surface; disposing magnetizable abrasive particles onto the make layer precursor while under the influence of an applied magnetic field , such that at least a majority the magnetizable abrasive particles extend away from the make layer precursor in an orientation substantially aligned with the applied magnetic field ; the method being characterized in that it further comprises the steps of: disposing non-magnetizable particles onto the make layer precursor , wherein at least some of the non-magnetizable particles are disposed between the magnetizable abrasive particles while under the influence of the applied magnetic field ; and at least partially curing the make layer precursor to provide a make layer .
Powder for use in a layer-by-layer process for producing mouldings by selectively melting regions of the respective powder layer through introduction of electromagnetic energy, comprising composite particles which are produced from core particles completely or partially coated with a precipitated polymer, where the core particles are inorganic core particles, with the exception of titanium dioxide, and where the d 50 median diameter of the inorganic core particles is from 1 to 70 μm, characterized in that the inorganic core particles have been selected from the group of polyphosphates and phosphinates.
A bioactive glass composition comprising: 5-10 mol% gallium oxide; 25 to 75 mol% silicon dioxide; 10 to 30 mol% calcium oxide and/or strontium oxide; 1 to 30 mol% sodium oxide; and 1 to 15 mol% phosphorous pentoxide. 5-10 mol% gallium oxide; 25 to 75 mol% silicon dioxide; 10 to 30 mol% calcium oxide and/or strontium oxide; 1 to 30 mol% sodium oxide; and 1 to 15 mol% phosphorous pentoxide.
A cutting wheel assembly comprising: • a frame ; • a pair of outer cutting wheels arranged either side of an inner cutting wheel all supported on the lower portions of the frame in a rotatable manner; • each cutting wheel having a central hub portion about which an annular cutting portion is provided, each annular cutting portion having a respective cutting diameter; • the inner cutting wheel having a different cutting diameter to that of both the outer cutting wheels , characterised in that: the frame has two spaced support pillars (70-1, 70-2), each pillar having an upper portion , an intermediate portion and a lower portion , the intermediate portion at an angle to the upper and lower portions , the wheels supported on the lower portions of the support pillars (70-1, 70-2) in a rotatable manner about a common axis of rotation, and the central hub portions of neighbouring cutting wheels defining a respective gap (G1) in which the intermediate portion of a respective pillar is received; and further in which • at least one of the annular cutting portions of the inner cutting wheel and/or the outer cutting wheels having one or more rim portion(s) that overlap each gap (G1), so the annular cutting portions of the cutting wheels provide a cutting action along a continuous line of cut in a lateral direction. • a frame ; • a pair of outer cutting wheels arranged either side of an inner cutting wheel all supported on the lower portions of the frame in a rotatable manner; • each cutting wheel having a central hub portion about which an annular cutting portion is provided, each annular cutting portion having a respective cutting diameter; • the inner cutting wheel having a different cutting diameter to that of both the outer cutting wheels , characterised in that: the frame has two spaced support pillars (70-1, 70-2), each pillar having an upper portion , an intermediate portion and a lower portion , the intermediate portion at an angle to the upper and lower portions , the wheels supported on the lower portions of the support pillars (70-1, 70-2) in a rotatable manner about a common axis of rotation, and the central hub portions of neighbouring cutting wheels defining a respective gap (G1) in which the intermediate portion of a respective pillar is received; and further in which • at least one of the annular cutting portions of the inner cutting wheel and/or the outer cutting wheels having one or more rim portion(s) that overlap each gap (G1), so the annular cutting portions of the cutting wheels provide a cutting action along a continuous line of cut in a lateral direction.
A method for culturing epithelial stem cells or an isolated tissue fragment comprising said epithelial stem cells, the method comprising providing an extracellular matrix; incubating said epithelial stem cells or said isolated tissue fragment comprising said epithelial stem cells with the extracellular matrix; culturing the epithelial stem cells or isolated tissue fragment in the presence of a cell culture medium comprising a basal medium for animal or human cells to which is added: noggin; between 5 and 500 ngram/ml of a mitogenic growth factor selected from epidermal growth factor (EGF), transforming growth factor-alpha, fibroblast growth factor (FGF), brain-derived neurotrophic factor and keratinocyte growth factor (KGF); and a Wnt agonist selected from R-spondin 1, R-spondin 2, R-spondin 3 and R-spondin 4. providing an extracellular matrix; incubating said epithelial stem cells or said isolated tissue fragment comprising said epithelial stem cells with the extracellular matrix; culturing the epithelial stem cells or isolated tissue fragment in the presence of a cell culture medium comprising a basal medium for animal or human cells to which is added: noggin; between 5 and 500 ngram/ml of a mitogenic growth factor selected from epidermal growth factor (EGF), transforming growth factor-alpha, fibroblast growth factor (FGF), brain-derived neurotrophic factor and keratinocyte growth factor (KGF); and a Wnt agonist selected from R-spondin 1, R-spondin 2, R-spondin 3 and R-spondin 4. noggin; between 5 and 500 ngram/ml of a mitogenic growth factor selected from epidermal growth factor (EGF), transforming growth factor-alpha, fibroblast growth factor (FGF), brain-derived neurotrophic factor and keratinocyte growth factor (KGF); and a Wnt agonist selected from R-spondin 1, R-spondin 2, R-spondin 3 and R-spondin 4.
A machine for making a continuous rod (C) of the tobacco industry, comprising a forming station , adapted to receive a web of wrapping material (I) from means for feeding the web of wrapping material (I) and a semi-finished product (P) of the tobacco industry from means for feeding the semi-finished product (P), wherein the station comprises a rod forming beam on which the semi-finished product (P) is placed above the web of wrapping material (I) or resting on top of the web of wrapping material (I), the forming station being configured to progressively wrap the web of wrapping material (I) round the semi-finished product (P) to form a continuous rod (C) of semi-finished product (P) wrapped in a tube of wrapping material; - a conveyor belt configured to move the web of wrapping material (I) and the semi-finished product (P) along a processing direction (X), the conveyor belt having an initial stretch which receives the semi-finished product (P) and wherein the initial stretch of the web of wrapping material (I) is planar; - a detecting station disposed in proximity to the rod forming beam and comprising at least one electromagnetic detector for detecting one or more properties of the semi-finished product (P), the electromagnetic detector being disposed in proximity to a stretch of the rod forming beam upstream of the point where the web of wrapping material is completely wrapped round the semi-finished product (P) so that the electromagnetic detector faces a surface of the semi-finished product (P) which is not yet wrapped completely in the web of wrapping material (I); characterized in that said detecting station comprises an opposing belt disposed above the conveyor belt and configured to define, in the initial stretch, a channel in which the semi-finished product (P) passes together with the web of wrapping material (I), the electromagnetic detector being disposed on the channel. - a conveyor belt configured to move the web of wrapping material (I) and the semi-finished product (P) along a processing direction (X), the conveyor belt having an initial stretch which receives the semi-finished product (P) and wherein the initial stretch of the web of wrapping material (I) is planar; - a detecting station disposed in proximity to the rod forming beam and comprising at least one electromagnetic detector for detecting one or more properties of the semi-finished product (P), the electromagnetic detector being disposed in proximity to a stretch of the rod forming beam upstream of the point where the web of wrapping material is completely wrapped round the semi-finished product (P) so that the electromagnetic detector faces a surface of the semi-finished product (P) which is not yet wrapped completely in the web of wrapping material (I); characterized in that said detecting station comprises an opposing belt disposed above the conveyor belt and configured to define, in the initial stretch, a channel in which the semi-finished product (P) passes together with the web of wrapping material (I), the electromagnetic detector being disposed on the channel.
A power combiner/splitter comprising: a common port (P1); a plurality of input/output ports including a first input/output port (P2) and a second input/output port (P3); a first quarter-wave element coupled between the common port and the first input/output port; a first switch (S 2,b ) coupled between the first input/output port and a reference voltage node ; a second quarter-wave element coupled between the common port and the second input/output port; a second switch (S 3,b ) coupled between the second input/output port and the reference voltage node, characterised in that each of the first and second quarter-wave elements has a programmable characteristic impedance. a common port (P1); a plurality of input/output ports including a first input/output port (P2) and a second input/output port (P3); a first quarter-wave element coupled between the common port and the first input/output port; a first switch (S 2,b ) coupled between the first input/output port and a reference voltage node ; a second quarter-wave element coupled between the common port and the second input/output port; a second switch (S 3,b ) coupled between the second input/output port and the reference voltage node, characterised in that each of the first and second quarter-wave elements has a programmable characteristic impedance.
A teleoperated manipulator system comprising: a mounting base ; an arm comprising a distal pitch arc portion, a pitch-adjustment actuator , and a movable link , the arm being coupled to the mounting base to rotate around a yaw axis , the movable link having a proximal end and a distal end, the proximal end of the movable link being coupled to the pitch-adjustment actuator, the pitch arc portion defining a pitch arc having a center; a tool actuator assembly coupling coupled to translate on a curvilinear path in the pitch arc portion of the arm , the distal end of the movable link of the arm being coupled to the tool actuator assembly coupling ; and a tool actuator assembly coupled to the tool actuator assembly coupling , a long axis of the tool actuator assembly defining a tool insertion axis ; wherein the yaw axis , the center of the pitch arc, and the tool insertion axis are coincident and define a remote center of motion of the manipulator system , wherein: the distal pitch arc portion of the arm comprises a fixed arcuate segment and a movable arcuate segment coupled to the fixed arcuate segment, the fixed arcuate segment and the movable arcuate segment together defining the pitch arc ; the movable arcuate segment is coupled to translate on a curvilinear path in the fixed arcuate segment; and the tool actuator assembly coupling is coupled to translate on a curvilinear path in the movable arcuate segment. a mounting base ; an arm comprising a distal pitch arc portion, a pitch-adjustment actuator , and a movable link , the arm being coupled to the mounting base to rotate around a yaw axis , the movable link having a proximal end and a distal end, the proximal end of the movable link being coupled to the pitch-adjustment actuator, the pitch arc portion defining a pitch arc having a center; a tool actuator assembly coupling coupled to translate on a curvilinear path in the pitch arc portion of the arm , the distal end of the movable link of the arm being coupled to the tool actuator assembly coupling ; and a tool actuator assembly coupled to the tool actuator assembly coupling , a long axis of the tool actuator assembly defining a tool insertion axis ; wherein the yaw axis , the center of the pitch arc, and the tool insertion axis are coincident and define a remote center of motion of the manipulator system , the distal pitch arc portion of the arm comprises a fixed arcuate segment and a movable arcuate segment coupled to the fixed arcuate segment, the fixed arcuate segment and the movable arcuate segment together defining the pitch arc ; the movable arcuate segment is coupled to translate on a curvilinear path in the fixed arcuate segment; and the tool actuator assembly coupling is coupled to translate on a curvilinear path in the movable arcuate segment.
A method for regulating the speed and power of a turbomachine propeller, wherein at least two operating modes are implemented: - one, called "speed mode", in which the propeller pitch (β) is controlled based on the desired propeller speed, while the fuel flow rate is controlled based on the desired torque, - the other, called "β mode", in which the fuel flow rate is controlled based on the desired propeller speed, the propeller pitch (β) being set at a stop angle (βmin) which limits the propeller pitch in the two operating modes, characterized in that the stop angle (βmin(t)) is calculated and continuously updated during a flight based on parameters relating to the flight conditions estimated in real time. - one, called "speed mode", in which the propeller pitch (β) is controlled based on the desired propeller speed, while the fuel flow rate is controlled based on the desired torque, - the other, called "β mode", in which the fuel flow rate is controlled based on the desired propeller speed, the propeller pitch (β) being set at a stop angle (βmin) which limits the propeller pitch in the two operating modes, characterized in that the stop angle (βmin(t)) is calculated and continuously updated during a flight based on parameters relating to the flight conditions estimated in real time.