An article , comprising: a first side comprising: a central portion defined by a first edge; a microneedle-free peripheral portion that substantially surrounds the central portion; and a plurality of spaced-apart hollow microneedles extending from the central portion in a first direction; wherein each microneedle of the plurality comprises a body that includes: an outer surface; a base segment having a base and a first shape that is defined by the outer surface; a tip segment having a tip and a second shape that is defined by the outer surface, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment: a hollow channel extending through the body of the microneedle from a first opening proximate the tip to a second opening proximate the base; a central axis ; wherein the plurality of hollow microneedles forms an array that comprises three or more perimeter microneedles disposed proximate the first edge; wherein the central portion is not coplanar with the peripheral portion; wherein the peripheral portion is canted in a second direction relative to the central portion, wherein the second direction is opposite the first direction ; wherein an angle (Theta1), defined by an intersection of the central axis of at least one of the plurality of microneedles and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50°. a first side comprising: a central portion defined by a first edge; a microneedle-free peripheral portion that substantially surrounds the central portion; and a plurality of spaced-apart hollow microneedles extending from the a central portion defined by a first edge; a microneedle-free peripheral portion that substantially surrounds the central portion; and a plurality of spaced-apart hollow microneedles extending from the central portion in a first direction; wherein each microneedle of the plurality comprises a body that includes: an outer surface; a base segment having a base and a first shape that is defined by the an outer surface; a base segment having a base and a first shape that is defined by the outer surface; a tip segment having a tip and a second shape that is defined by the outer surface, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment: a hollow channel extending through the body of the microneedle from a first opening proximate the tip to a second opening proximate the base; a central axis ; a tip segment having a tip and a second shape that is defined by the outer surface, wherein the second shape is distinct from the first shape; a transition plane that delineates the base segment and the tip segment: a hollow channel extending through the body of the microneedle from a first opening proximate the tip to a second opening proximate the base; a central axis ; wherein the plurality of hollow microneedles forms an array that comprises three or more perimeter microneedles disposed proximate the first edge; wherein the central portion is not coplanar with the peripheral portion; wherein the peripheral portion is canted in a second direction relative to the central portion, wherein the second direction is opposite the first direction ; wherein an angle (Theta1), defined by an intersection of the central axis of at least one of the plurality of microneedles and a shortest line extending from the first edge and through the transition plane of the at least one microneedle, is less than about 50°. <EOS>