An apparatus, comprising: a housing ; a medicament containment chamber defining an internal volume configured to house a medicament, the medicament containment chamber being disposed within the housing and defining a range of motion of the actuator ; a needle; and an actuator including an engagement portion and a plunger portion movably disposed within the internal volume of the medicament containment chamber, the internal volume of the medicament containment chamber , the actuator , and the needle collectively configured such that the plunger portion of the actuator moves within the internal volume of the medicament containment chamber in response to a manually applied force on the engagement portion of the actuator via the housing when a first backpressure is produced on the distal tip of the needle, when the distal tip of the needle is disposed within a first region of target tissue, and movement of the plunger portion of the actuator within the internal volume in response to the force on the actuator is limited when a second backpressure higher than the first backpressure is produced on the distal tip of the needle, when the distal end portion of the needle is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value, characterised in that the apparatus further comprises a hub configured to be coupled to the housing and fluidically coupled to the medicament containment chamber , the hub defining a passageway configured to receive the needle therethrough, the distal end surface of the hub configured to contact a target tissue when a medicament is conveyed through the needle into the target tissue, and wherein the needle is fixedly coupled to the hub. a housing ; a medicament containment chamber defining an internal volume configured to house a medicament, the medicament containment chamber being disposed within the housing and defining a range of motion of the actuator ; a needle; and an actuator including an engagement portion and a plunger portion movably disposed within the internal volume of the medicament containment chamber, the internal volume of the medicament containment chamber , the actuator , and the needle collectively configured such that the plunger portion of the actuator moves within the internal volume of the medicament containment chamber in response to a manually applied force on the engagement portion of the actuator via the housing when a first backpressure is produced on the distal tip of the needle, when the distal tip of the needle is disposed within a first region of target tissue, and movement of the plunger portion of the actuator within the internal volume in response to the force on the actuator is limited when a second backpressure higher than the first backpressure is produced on the distal tip of the needle, when the distal end portion of the needle is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value, characterised in that the apparatus further comprises a hub configured to be coupled to the housing and fluidically coupled to the medicament containment chamber , the hub defining a passageway configured to receive the needle therethrough, the distal end surface of the hub configured to contact a target tissue when a medicament is conveyed through the needle into the target tissue, and wherein the needle is fixedly coupled to the hub. <EOS>