mhurhangee/patent-ind-claim-en huggingface dataset:
A process for the preparation of a hydrogel suitable as a carrier in a hydrogel-linked prodrug comprising the steps of (a) providing a hydrogel having groups A x0 , wherein the groups A x0 represent the same or different functional groups; (b) optionally covalently conjugating a spacer reagent of formula (I) A x1 -SP 2 -A x2 (I), wherein SP 2 is C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl, which C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl is optionally interrupted by one or more group(s) selected from the group consisting of -NH-, -N(C 1-4 alkyl)-, -O-, -S-, -C(O)-, -C(O)NH-, -C(O)N(C 1-4 alkyl)-, -O-C(O)-, -S(O)-, -S(O) 2 -, 4- to 7-membered heterocyclyl, phenyl and naphthyl; A x1 is a functional group for reaction with A x0 of the hydrogel; and A x2 is a functional group; to A x0 of the hydrogel from step (a); and (c) reacting the hydrogel of step (a) or step (b) with a reagent of formula (II) A x3 -Z (II), wherein A x3 is a functional group; and Z is an inert linear or branched PEG-based polymer comprising at least 70% PEG, wherein Z has a molecular weight ranging from 10 kDa to 250 kDa, and does not react with A x0 or A x2 or with other functional groups present; such that at most 80 mol-% of A x0 or A x2 react with A x3 . (a) providing a hydrogel having groups A x0 , wherein the groups A x0 represent the same or different functional groups; (b) optionally covalently conjugating a spacer reagent of formula (I) A x1 -SP 2 -A x2 (I), wherein SP 2 is C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl, which C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl is optionally interrupted by one or more group(s) selected from the group consisting of -NH-, -N(C 1-4 alkyl)-, -O-, -S-, -C(O)-, -C(O)NH-, -C(O)N(C 1-4 alkyl)-, -O-C(O)-, -S(O)-, -S(O) 2 -, 4- to 7-membered heterocyclyl, phenyl and naphthyl; A x1 is a functional group for reaction with A x0 of the hydrogel; and A x2 is a functional group; to A x0 of the hydrogel from step (a); and SP 2 is C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl, which C 1-50 alkyl, C 2-50 alkenyl or C 2-50 alkynyl is optionally interrupted by one or more group(s) selected from the group consisting of -NH-, -N(C 1-4 alkyl)-, -O-, -S-, -C(O)-, -C(O)NH-, -C(O)N(C 1-4 alkyl)-, -O-C(O)-, -S(O)-, -S(O) 2 -, 4- to 7-membered heterocyclyl, phenyl and naphthyl; A x1 is a functional group for reaction with A x0 of the hydrogel; and A x2 is a functional group; (c) reacting the hydrogel of step (a) or step (b) with a reagent of formula (II) A x3 -Z (II), wherein A x3 is a functional group; and Z is an inert linear or branched PEG-based polymer comprising at least 70% PEG, wherein Z has a molecular weight ranging from 10 kDa to 250 kDa, and does not react with A x0 or A x2 or with other functional groups present; A x3 is a functional group; and Z is an inert linear or branched PEG-based polymer comprising at least 70% PEG, wherein Z has a molecular weight ranging from 10 kDa to 250 kDa, and does not react with A x0 or A x2 or with other functional groups present;
The in vitro use of a DNA-tissue specific transcription factor or cofactor adduct as a biomarker in a biological fluid for the detection or diagnosis of a cancer in a subject, wherein the DNA-tissue specific transcription factor or cofactor adduct is a tissue specific transcription factor or cofactor bound to DNA.
A method for coding video information relating to a slice of an image, the slice comprising one or more blocks of video data, the method comprising: identifying a plurality of prediction modes for a fixed-rate codec, each prediction mode having a rate-distortion cost associated with the one or more blocks of video data; selecting , for a current block associated with the one or more blocks of the slice, a prediction mode that has the lowest rate-distortion cost from among the plurality of prediction modes; determining whether the selected prediction mode would result in overflow or underflow of a buffer of the fixed-rate codec or whether the selected prediction mode would result in remaining bits in the slice being insufficient to code remaining blocks of the slice; determining that the current block is a random noise region; coding the current block utilizing a fallback mode when the selected prediction mode would result in at least one of (i) overflow or underflow of the buffer or (ii) insufficient remaining bits in the slice to code the remaining blocks of the slice, wherein the fallback mode comprises determining a midpoint value; and predicting samples for the current block from the midpoint value, wherein the midpoint value is determined based on a mean of pixel value video data neighboring the current block. identifying a plurality of prediction modes for a fixed-rate codec, each prediction mode having a rate-distortion cost associated with the one or more blocks of video data; selecting , for a current block associated with the one or more blocks of the slice, a prediction mode that has the lowest rate-distortion cost from among the plurality of prediction modes; determining whether the selected prediction mode would result in overflow or underflow of a buffer of the fixed-rate codec or whether the selected prediction mode would result in remaining bits in the slice being insufficient to code remaining blocks of the slice; determining that the current block is a random noise region; coding the current block utilizing a fallback mode when the selected prediction mode would result in at least one of (i) overflow or underflow of the buffer or (ii) insufficient remaining bits in the slice to code the remaining blocks of the slice, wherein the fallback mode comprises determining a midpoint value; and predicting samples for the current block from the midpoint value, wherein the midpoint value is determined based on a mean of pixel value video data neighboring the current block.
An arithmetic operation method executed by a computer for performing arithmetic operations of a plurality of subtasks by using an arithmetic operation system equipped with an inexpensive execution unit for which a usage fee is inexpensive, but which may possibly be forcibly stopped, and an expensive execution unit for which a usage fee is expensive, but which will never be forcibly stopped, the arithmetic operation method characterized by : a simultaneous execution quantity calculation step of calculating a simultaneous execution quantity of the subtasks at each time of day on the basis of resources used by each of the subtasks and available resources at each time of day; an inexpensive remaining quantity calculation step of creating an inexpensive executability table indicating an inexpensive remaining quantity that is a quantity of tasks which may be executed by the inexpensive execution unit at each time of day on the basis of a completion date and time when the arithmetic operations of the plurality of subtasks should be completed, and the simultaneous execution quantity; and an execution instruction step of causing each of the subtasks to be executed by either the inexpensive execution unit or the expensive execution unit with reference to the inexpensive executability table . a simultaneous execution quantity calculation step of calculating a simultaneous execution quantity of the subtasks at each time of day on the basis of resources used by each of the subtasks and available resources at each time of day; an inexpensive remaining quantity calculation step of creating an inexpensive executability table indicating an inexpensive remaining quantity that is a quantity of tasks which may be executed by the inexpensive execution unit at each time of day on the basis of a completion date and time when the arithmetic operations of the plurality of subtasks should be completed, and the simultaneous execution quantity; and an execution instruction step of causing each of the subtasks to be executed by either the inexpensive execution unit or the expensive execution unit with reference to the inexpensive executability table .
Exendin(9-39) for use in treating and preventing hyperinsulinemic hypoglycemia and associated acute and chronic symptoms and outcomes in a patient by subcutaneous injection of a therapeutically effective dose comprising 2-100 mg of exendin(9-39).
Dialysis treatment arrangement for controlling and/or regulating a dialysis device, comprising: - a dialysis device for carrying out a medical dialysis treatment, - a patient supporting device for supporting a patient with an arrangement for carrying out a bio-impedance measurement on a patient's body, wherein this arrangement comprises - a device for coupling in a measurement signal into the patient's body and - a device for decoupling an electrical measurement variable, generated thereby in the patient's body, out of the patient's body, and an interface for connection to the dialysis device wherein the patient supporting device comprises a device for determining the patient's size with pressure sensors and/or pressure sensor fields, which are arranged in the region of patient supporting surfaces of the patient supporting device , and - an evaluation arrangement for evaluating the electrical measurement variable which has been decoupled by the arrangement for carrying out a bio-impedance measurement, taking into account the determined patient's size, and for transmitting the data correlated with the evaluated electrical measurement variable to the dialysis device via the interface, wherein the dialysis device is configured to be controlled and/or regulated by the data correlated with the evaluated electrical measurement variable. - a dialysis device for carrying out a medical dialysis treatment, - a patient supporting device for supporting a patient with an arrangement for carrying out a bio-impedance measurement on a patient's body, wherein this arrangement comprises - a device for coupling in a measurement signal into the patient's body and - a device for decoupling an electrical measurement variable, generated thereby in the patient's body, out of the patient's body, and an interface for connection to the dialysis device wherein the patient supporting device comprises a device for determining the patient's size with pressure sensors and/or pressure sensor fields, which are arranged in the region of patient supporting surfaces of the patient supporting device , and - an evaluation arrangement for evaluating the electrical measurement variable which has been decoupled by the arrangement for carrying out a bio-impedance measurement, taking into account the determined patient's size, and for transmitting the data correlated with the evaluated electrical measurement variable to the dialysis device via the interface, wherein the dialysis device is configured to be controlled and/or regulated by the data correlated with the evaluated electrical measurement variable.
A work vehicle comprising a forward part supported on a pair of forward ground engaging wheels , and a rearward part supported on a pair of rearward ground engaging wheels , at least one of the pairs of forward ground engaging wheels and rearward ground engaging wheels being rotatably driven by at least one hydraulic drive motor , the rearward part of the work vehicle being pivotally coupled to the forward part thereof about a substantially vertically extending main pivot axis for facilitating steering of the work vehicle, a power take-off shaft rotatably mounted in the forward part of the work vehicle, an engine located in the work vehicle, and a first hydraulic pump located in the work vehicle powered by drive derived from the engine , the first hydraulic pump being configured to produce an hydraulic power supply for powering the at least one hydraulic drive motor , characterised in that the engine and the first hydraulic pump are located in the rearward part of the work vehicle, the engine comprising a main output shaft , and the first hydraulic pump is powered by drive derived from the main output shaft of the engine , a mechanical step-down drive transmission means is located in the rearward part of the work vehicle, the mechanical step-down drive transmission means having an input shaft driven by drive derived from the main output drive shaft of the engine and an output shaft for producing drive for transmission to the power take-off shaft , the mechanical step-down drive transmission means having a step-down gear ratio to produce drive on the output shaft thereof of rotational speed less than the rotational speed of the main output drive shaft of the engine , and a main mechanical drive transmission means transmits drive from the output shaft of the mechanical step-down drive transmission means to the power take-off shaft located in the forward part of the work vehicle.
A cooker comprising: a housing having a cooking chamber and an exhaust hole; at least one electric component installed in the housing ; a steam generator installed on the housing , the steam generator supplying steam into the cooking chamber ; a cooling fan generating an airflow for cooling the at least one electric component and an airflow introduced into the cooking chamber , air sucked into the cooking chamber by the cooling fan being circulated in the inside of the cooking chamber ; a duct disposed outside the cooking chamber and arranged to cover the exhaust hole to guide air discharged to the outside of the cooking chamber , and a guide duct disposed outside the housing and below a base plate disposed at a lower portion of the housing , wherein steam contained in the air discharged to the outside of the cooking chamber is condensed in the duct , wherein condensed water generated by condensing steam through the duct is discharged through an exhaust hole defined in the base plate , and wherein the guide duct is configured to guide the air discharged through the exhaust hole and collecting the condensed water discharged through the exhaust hole . a housing having a cooking chamber and an exhaust hole; at least one electric component installed in the housing ; a steam generator installed on the housing , the steam generator supplying steam into the cooking chamber ; a cooling fan generating an airflow for cooling the at least one electric component and an airflow introduced into the cooking chamber , air sucked into the cooking chamber by the cooling fan being circulated in the inside of the cooking chamber ; a duct disposed outside the cooking chamber and arranged to cover the exhaust hole to guide air discharged to the outside of the cooking chamber , and a guide duct disposed outside the housing and below a base plate disposed at a lower portion of the housing , wherein steam contained in the air discharged to the outside of the cooking chamber is condensed in the duct , wherein condensed water generated by condensing steam through the duct is discharged through an exhaust hole defined in the base plate , and wherein the guide duct is configured to guide the air discharged through the exhaust hole and collecting the condensed water discharged through the exhaust hole .
A first software defined network, SDN, controller as a parent controller, the first SDN controller communicating with a second SDN controller according to a border gateway protocol, BGP, the first SDN controller being configured to: • receive a request to create an end to end, E2E, tunnel from a source to a destination; • send a first request message to the second SDN controller as child controller to cause the second SDN controller to compute path segments of a domain controlled by the second SDN controller, as well as path segments between adjacent domains using inter-domain links (step 6025); • receive a response message from the second SDN controller, the response message containing the computed path segments of the domain controlled by the second SDN controller and containing the computed path segments between adjacent domains; • determine a tunnel segment corresponding to the E2E tunnel based on the computed path segments of the domain controlled by the second SDN controller and based on the computed path segments between adjacent domains; • send a second request message to the second SDN controller, the second request message being used to create the tunnel segment at the second SDN controller, the E2E tunnel crossing the domain of the second SDN controller, and the second request message containing an indication denoting the tunnel segment (step 6045). • receive a request to create an end to end, E2E, tunnel from a source to a destination; • send a first request message to the second SDN controller as child controller to cause the second SDN controller to compute path segments of a domain controlled by the second SDN controller, as well as path segments between adjacent domains using inter-domain links (step 6025); • receive a response message from the second SDN controller, the response message containing the computed path segments of the domain controlled by the second SDN controller and containing the computed path segments between adjacent domains; • determine a tunnel segment corresponding to the E2E tunnel based on the computed path segments of the domain controlled by the second SDN controller and based on the computed path segments between adjacent domains; • send a second request message to the second SDN controller, the second request message being used to create the tunnel segment at the second SDN controller, the E2E tunnel crossing the domain of the second SDN controller, and the second request message containing an indication denoting the tunnel segment (step 6045).
A child safety seat configured to secure an occupant seated in the child safety seat with a safety belt of a vehicle, comprising - a seat base ; and - a safety belt clip , wherein the safety belt clip is coupled to the seat base of the child safety seat and the safety belt clip is adapted to engage with a lap portion of a safety belt , the safety belt clip comprising a guiding element comprising an engaging element and a positioning component , wherein the positioning component is adapted to position the engaging element at a distance from the seat base ; wherein the engaging element is adapted to engage with the lap portion of the safety belt ; and wherein the guiding element is configured to drive the lap portion of the safety belt towards the pelvic region of the occupant secured in the child safety seat with the safety belt . - a seat base ; and - a safety belt clip , wherein the safety belt clip is coupled to the seat base of the child safety seat and the safety belt clip is adapted to engage with a lap portion of a safety belt , the safety belt clip comprising a guiding element comprising an engaging element and a positioning component ,
A home electric appliance having a main body , a top part of which becomes warmer as a result of a basic operation, the home electric appliance comprising: a weight measurement unit configured to measure a weight of a measurement target object placed on the top part , and to output measurement information; a controller configured to perform a weight detection operation of detecting the weight of the measurement target object based on the measurement information from the weight measurement unit , and a plurality of operation units , wherein the top part includes a back surface that faces an inside of the main body , and the weight measurement unit is installed on the back surface of the top part , the plurality of operation units include a first operation unit (4Aa, 4B3, 4Ca) configured to receive a start instruction in relation to the basic operation, and at least two second operation units (4Ab, 4Ac, 4Ad, 4B1, 4B2, 4B3, 4Cb, 4Cc, 4Cd) for an instruction other than the start instruction regarding the basic operation, and characterized in that the controller starts the weight detection operation based on simultaneous operation of two or more of the second operation units (4Ab, 4Ac, 4Ad, 4B1, 4B2, 4B3, 4Cb, 4Cc, 4Cd). a weight measurement unit configured to measure a weight of a measurement target object placed on the top part , and to output measurement information; a controller configured to perform a weight detection operation of detecting the weight of the measurement target object based on the measurement information from the weight measurement unit , and a plurality of operation units , wherein the top part includes a back surface that faces an inside of the main body , and the weight measurement unit is installed on the back surface of the top part , the plurality of operation units include a first operation unit (4Aa, 4B3, 4Ca) configured to receive a start instruction in relation to the basic operation, and at least two second operation units (4Ab, 4Ac, 4Ad, 4B1, 4B2, 4B3, 4Cb, 4Cc, 4Cd) for an instruction other than the start instruction regarding the basic operation, and characterized in that the controller starts the weight detection operation based on simultaneous operation of two or more of the second operation units (4Ab, 4Ac, 4Ad, 4B1, 4B2, 4B3, 4Cb, 4Cc, 4Cd).
Packaging for housing a plurality of articles comprising an outer packaging , made of a first packaging material, with an outer packaging container and an outer packaging lid , an inner packaging for housing the articles, made of a second packaging material, with an inner packaging container and an inner packaging lid , and wherein the outer packaging is at least partially housing the inner packaging, wherein in a closed state of the packaging before the first opening thereof the inner packaging is fixedly attached via a first connection to an inner surface of the outer packaging lid , characterized in that at least one face of the outer packaging lid comprises a deformable section such that the first opening of the packaging requires a pressure to be applied upon said deformable section so as to break said first connection between the inner packaging and the inner surface of the outer packaging lid , wherein after breaking the first connection, the inner packaging is arranged to be moveable in a longitudinal direction in relation to the outer packaging . an inner packaging for housing the articles, made of a second packaging material, with an inner packaging container and an inner packaging lid , and wherein the outer packaging is at least partially housing the inner packaging, wherein in a closed state of the packaging before the first opening thereof the inner packaging is fixedly attached via a first connection to an inner surface of the outer packaging lid , characterized in that at least one face of the outer packaging lid comprises a deformable section such that the first opening of the packaging requires a pressure to be applied upon said deformable section so as to break said first connection between the inner packaging and the inner surface of the outer packaging lid , wherein after breaking the first connection, the inner packaging is arranged to be moveable in a longitudinal direction in relation to the outer packaging .