mhurhangee/patent-ind-claim-en huggingface dataset:
A method for preparing an isolated population of T cells that express a T cell receptor (TCR), or an antigen-binding portion thereof, having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, wherein the cancer is selected from colon cancer and rectal cancer, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous antigen presenting cells (APCs) of the patient to present the mutated amino acid sequence; co-culturing autologous T cells from a tumor of the patient with the autologous APCs that present the mutated amino acid sequence; selecting the autologous T cells that (a) were co-cultured with the autologous APCs that present the mutated amino acid sequence and (b) have antigenic specificity for the mutated amino acid sequence presented in the context of a major histocompatibility complex (MHC) molecule expressed by the patient; isolating a nucleotide sequence that encodes the TCR, or the antigen-binding portion thereof, from the selected autologous T cells, wherein the TCR, or the antigen-binding portion thereof, has antigenic specificity for the mutated amino acid sequence encoded by the cancer-specific mutation; and introducing the nucleotide sequence encoding the isolated TCR, or the antigen-binding portion thereof, into peripheral blood mononuclear cells (PBMC) to obtain cells that express the TCR, or the antigen-binding portion thereof. identifying one or more genes in the nucleic acid of a cancer cell of a patient, wherein the cancer is selected from colon cancer and rectal cancer, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous antigen presenting cells (APCs) of the patient to present the mutated amino acid sequence; co-culturing autologous T cells from a tumor of the patient with the autologous APCs that present the mutated amino acid sequence; selecting the autologous T cells that (a) were co-cultured with the autologous APCs that present the mutated amino acid sequence and (b) have antigenic specificity for the mutated amino acid sequence presented in the context of a major histocompatibility complex (MHC) molecule expressed by the patient; isolating a nucleotide sequence that encodes the TCR, or the antigen-binding portion thereof, from the selected autologous T cells, wherein the TCR, or the antigen-binding portion thereof, has antigenic specificity for the mutated amino acid sequence encoded by the cancer-specific mutation; and introducing the nucleotide sequence encoding the isolated TCR, or the antigen-binding portion thereof, into peripheral blood mononuclear cells (PBMC) to obtain cells that express the TCR, or the antigen-binding portion thereof.
A substance detecting element comprising: a supporting substrate in which a through-hole is disposed; a plate-shaped beam that comprises a piezoelectric element , extending from an edge of the through-hole toward an opposite edge to close a part of the through-hole , supporting a substance adsorption film to which a substance to be detected adheres, and extending and contracting due to application of a voltage, the beam being bent and vibrated due to the extension and contraction of the piezoelectric element ; drive electrodes provided for applying a voltage to the piezoelectric element to vibrate and deform the beam; and detection electrodes provided for outputting a voltage generated in the piezoelectric element for detecting information about a vibration frequency of the beam , the beam comprising an elongated plate-shaped first beam having both ends fixed to edges of the through-hole and provided with the drive electrodes on both ends and an elongated plate-shaped second beam having both ends fixed to edges of the through-hole and provided with the detection electrodes on both ends, the second beam intersecting the first beam , the first beam and the second beam being coupled to each other at respective middles of the first beam and the second beam , characterized in that a width of the first beam is set to be wider than a width of the second beam . a supporting substrate in which a through-hole is disposed; a plate-shaped beam that comprises a piezoelectric element , extending from an edge of the through-hole toward an opposite edge to close a part of the through-hole , supporting a substance adsorption film to which a substance to be detected adheres, and extending and contracting due to application of a voltage, the beam being bent and vibrated due to the extension and contraction of the piezoelectric element ; drive electrodes provided for applying a voltage to the piezoelectric element to vibrate and deform the beam; and detection electrodes provided for outputting a voltage generated in the piezoelectric element for detecting information about a vibration frequency of the beam , the beam comprising an elongated plate-shaped first beam having both ends fixed to edges of the through-hole and provided with the drive electrodes on both ends and an elongated plate-shaped second beam having both ends fixed to edges of the through-hole and provided with the detection electrodes on both ends, the second beam intersecting the first beam , the first beam and the second beam being coupled to each other at respective middles of the first beam and the second beam , characterized in that the first beam and the second beam being coupled to each other at respective middles of the first beam and the second beam , characterized in that a width of the first beam is set to be wider than a width of the second beam .
An interlayer film for a laminated glass, having a large number of protrusions, the shapes of which include spherical or blockish shapes, on at least one surface, wherein the protrusions each have an arithmetical mean height Sa on the surface of 200 nm or more and 3,000 nm or less as measured in conformity with ISO 25178, the surface having an arrangement density of the protrusions of 5 protrusions/mm 2 or more measured according to the description, and the protrusions having an area ratio as measured according to the description of 15% to 75% to the surface. wherein the protrusions each have an arithmetical mean height Sa on the surface of 200 nm or more and 3,000 nm or less as measured in conformity with ISO 25178, the surface having an arrangement density of the protrusions of 5 protrusions/mm 2 or more measured according to the description, and the protrusions having an area ratio as measured according to the description of 15% to 75% to the surface.
An apparatus for control of aircraft pitch comprising: a horizontal control column configured to extend from a control wheel horizontally towards a front wall of an aircraft cockpit; a pitch output link having a first pitch output link connection point and a second pitch output link connection point configured to be connected to a downstream pitch control mechanism , wherein the pitch output link is configured to transfer a force applied at the first pitch output link connection point to the downstream pitch control mechanism; a transfer assembly connected to the horizontal control column and to the pitch output link at the first pitch output link connection point , wherein the transfer assembly is configured to translate a horizontal force applied to the horizontal control column to the pitch output link ; and characterized by a roll control shaft connectable to the control wheel and extending through the horizontal control column and through a front end opening of the horizontal control column; and a self-aligning bearing connectable to an aircraft structure portion and positioned to support the roll control shaft. a horizontal control column configured to extend from a control wheel horizontally towards a front wall of an aircraft cockpit; a pitch output link having a first pitch output link connection point and a second pitch output link connection point configured to be connected to a downstream pitch control mechanism , wherein the pitch output link is configured to transfer a force applied at the first pitch output link connection point to the downstream pitch control mechanism; a transfer assembly connected to the horizontal control column and to the pitch output link at the first pitch output link connection point , wherein the transfer assembly is configured to translate a horizontal force applied to the horizontal control column to the pitch output link ; and characterized by a roll control shaft connectable to the control wheel and extending through the horizontal control column and through a front end opening of the horizontal control column; and a self-aligning bearing connectable to an aircraft structure portion and positioned to support the roll control shaft.
A fitting for a metallic-composite joint, comprising: a frustoconical internal bearing ; an internal bolt coupled within a bore of the frustoconical internal bearing; a metallic end fitting configured to couple to the internal bolt, wherein the metallic end fitting comprises a bearing portion configured to be disposed within the bore; a conical sleeve disposed about the frustoconical internal bearing; and an external nut configured to couple to the metallic end fitting and the conical sleeve; and characterized in that the metallic end fitting is coupled to the internal bolt at an internally threaded surface of the metallic end fitting. a frustoconical internal bearing ; an internal bolt coupled within a bore of the frustoconical internal bearing; a metallic end fitting configured to couple to the internal bolt, wherein the metallic end fitting comprises a bearing portion configured to be disposed within the bore; a conical sleeve disposed about the frustoconical internal bearing; and an external nut configured to couple to the metallic end fitting and the conical sleeve; and characterized in that the metallic end fitting is coupled to the internal bolt at an internally threaded surface of the metallic end fitting.
A wind turbine rotor blade assembly comprising: a rotor blade having exterior surfaces defining a pressure side, a suction side, a leading edge and a trailing edge, each of the pressure side, the suction side, the leading edge and the trailing edge extending between a tip end and a root end, the rotor blade defining a span and a chord, a noise reducer configured on the rotor blade, the noise reducer comprising a plurality of aligned spine members , each spine member having a length and comprising a first section extending along a first part of the length of the spine member, and a second section extending along a second part of the length of the spine member, wherein the first section has a higher stiffness than the second section , wherein the first section is adjacent to the second section such that an interface is formed between the first section and the second section , characterised in that the chordwise location of the interface varies between different spine members of the noise reducer . a rotor blade having exterior surfaces defining a pressure side, a suction side, a leading edge and a trailing edge, each of the pressure side, the suction side, the leading edge and the trailing edge extending between a tip end and a root end, the rotor blade defining a span and a chord, a noise reducer configured on the rotor blade, the noise reducer comprising a plurality of aligned spine members , each spine member having a length and comprising a first section extending along a first part of the length of the spine member, and a second section extending along a second part of the length of the spine member, a first section extending along a first part of the length of the spine member, and a second section extending along a second part of the length of the spine member, wherein the first section has a higher stiffness than the second section , wherein the first section is adjacent to the second section such that an interface is formed between the first section and the second section , characterised in that the chordwise location of the interface varies between different spine members of the noise reducer .
A sheet processing apparatus , comprising: a housing section (120; 303) configured to accommodate a sheet (G; P); a conveyance mechanism (122; 305) configured to convey the sheet (G; P) accommodated in the housing section (120; 303) to a predetermined position (124; 307) at a downstream side of a sheet conveyance path (126; 330) in a sheet conveyance direction; a controller configured to control the conveyance mechanism to remove a needle-free binding section of a sheet bundle including, as an uppermost sheet, the sheet (G; P), if a conveyance jam of the sheet (G; P) occurs; and a document sensor configured to detect the sheet (G; P) moving along the document conveyance path , wherein the conveyance mechanism (122; 305) comprises a second roller (132; 336) configured to convey the sheet (G; P) accommodated in the housing section (120; 303) towards the downstream side in the sheet conveyance direction, and a third roller (134; 338) arranged opposite to the second roller (132; 336) and forming a nip for sandwiching the sheet (G; P), the controller is configured to perform control to rotate the second roller (132; 336) and the third roller (134; 338) such that the second roller (132; 336) and the third roller (134; 338) rotate in the sheet conveyance direction at different rotation speeds from each other if the conveyance jam of the sheet (G; P) occurs in order to remove the needle-free binding section, wherein the controller is configured to determine if the conveyance jam of the sheet (G; P) occurs using a detection result of the document sensor . a housing section (120; 303) configured to accommodate a sheet (G; P); a conveyance mechanism (122; 305) configured to convey the sheet (G; P) accommodated in the housing section (120; 303) to a predetermined position (124; 307) at a downstream side of a sheet conveyance path (126; 330) in a sheet conveyance direction; a controller configured to control the conveyance mechanism to remove a needle-free binding section of a sheet bundle including, as an uppermost sheet, the sheet (G; P), if a conveyance jam of the sheet (G; P) occurs; and a document sensor configured to detect the sheet (G; P) moving along the document conveyance path ,
An imaging device for producing an image of a scene, comprising a series of tiles, each tile comprising a series of pixels ; each pixel comprising a sample and hold circuit (M1, M2, M3, C1, C2) including a storage capacitor (C2, C4, C6); characterised in that the pixels of each tile are arranged into at least two groups the sample and hold circuits of pixels within a group of the same tile being connected through interconnecting switches and charge sharing circuitry to allow signal charges held on the storage capacitors of those pixels to be shared resulting in a shared signal voltage to be held on the storage capacitor of each pixel of the same group within that tile; and a comparator (A1) arranged to compare a shared signal voltage held on storage capacitors of pixels of a first group within the tile with a shared signal voltage held on storage capacitors of pixels of a second group within the tile; the results of the comparison being used by readout control of the imaging device to control whether a pixel level readout operation is carried out for that tile or tile average readout operation is carried out for that tile.
A system for receiving condensate from a v-coil heat exchanger (v-coil) , comprising: a receptor (141; 142) comprising: a first channel (151; 152) having a first length defined between first opposing ends , the first channel configured to receive the v-coil, the first channel having a first bottom surface (201; 202); a second channel (161; 162) disposed at an angle to the first channel and connecting with the first channel at a junction (181; 182) so that fluid flows downstream from the first channel into the second channel, the second channel having a second bottom surface (161a; 162a) that extends below the first bottom surface; and a heat shield (300; 302) connected to the first channel and extending below the first channel, wherein: a bottom surface of the heat shield is level with the second bottom surface of the second channel; and the bottom surface of the heat shield forms a rounded base, characterized in that : the heat shield connects with the first channel at top edges of opposing side walls (151a, 151b; 152a, 152b) of the first channel. a first channel (151; 152) having a first length defined between first opposing ends , the first channel configured to receive the v-coil, the first channel having a first bottom surface (201; 202); a second channel (161; 162) disposed at an angle to the first channel and connecting with the first channel at a junction (181; 182) so that fluid flows downstream from the first channel into the second channel, the second channel having a second bottom surface (161a; 162a) that extends below the first bottom surface; and a heat shield (300; 302) connected to the first channel and extending below the first channel, wherein: a bottom surface of the heat shield is level with the second bottom surface of the second channel; and the bottom surface of the heat shield forms a rounded base, characterized in that : the heat shield connects with the first channel at top edges of opposing side walls (151a, 151b; 152a, 152b) of the first channel. a bottom surface of the heat shield is level with the second bottom surface of the second channel; and the bottom surface of the heat shield forms a rounded base, characterized in that : the heat shield connects with the first channel at top edges of opposing side walls (151a, 151b; 152a, 152b) of the first channel.
A die set for a crimping device , the die set having a front side and a rear side that is opposite the front side , the die set including a first crimp die and a second crimp die that have respective forming surfaces for engaging an object to crimp the object as at least one of the first and second crimp dies moves along a crimp stroke relative to the other crimp die, and the dies set including a die clearance monitoring system comprising: a light detector disposed along the rear side of the die set ; and a controller including one or more processors connected to the light detector , characterized in that the die clearance monitoring system includes a light source disposed along the front side of the die set and configured to emit light towards the die set; the light detector is configured to receive the emitted light from the light source that traverses across the die set through a gap defined between the first and second crimp dies and generate light absorption data based on the emitted light that is received; and the controller is configured to process the light absorption data to determine a relative spacing between the first crimp die and the second crimp die . a light detector disposed along the rear side of the die set ; and a controller including one or more processors connected to the light detector , characterized in that the die clearance monitoring system includes a light source disposed along the front side of the die set and configured to emit light towards the die set; the light detector is configured to receive the emitted light from the light source that traverses across the die set through a gap defined between the first and second crimp dies and generate light absorption data based on the emitted light that is received; and the controller is configured to process the light absorption data to determine a relative spacing between the first crimp die and the second crimp die .
A vial cap for removing a matrix component from a liquid sample and transferring the liquid sample in a sample vial to an injection valve at the same time, the vial cap comprising: a cap body including a liquid sample passageway , and an outer periphery configured to have a slidable gas and liquid seal with a side wall of a sample vial ; an inlet portion configured to receive a pressurized liquid sample from the sample vial where the liquid sample flows into the liquid sample passageway , the inlet portion including a counterbore section , the counterbore section holding a filter plug , the filter plug comprising high density polyethylene resin particles and a matrix component binding material selected from the group consisting of an ion exchange material and a reversed-phase material, the high density polyethylene resin particles being fused together to bind the matrix component binding material, the binding material being physically entrapped within a void volume in the fused high density polyethylene; an outlet portion configured to output the liquid sample from the liquid sample passageway that has passed through the filter plug , the outlet portion including a plunger section configured to receive a downward force into a sample vial to pressurize the liquid sample within the sample vial. a cap body including a liquid sample passageway , and an outer periphery configured to have a slidable gas and liquid seal with a side wall of a sample vial ; an inlet portion configured to receive a pressurized liquid sample from the sample vial where the liquid sample flows into the liquid sample passageway , the inlet portion including a counterbore section , the counterbore section holding a filter plug , the filter plug comprising high density polyethylene resin particles and a matrix component binding material selected from the group consisting of an ion exchange material and a reversed-phase material, the high density polyethylene resin particles being fused together to bind the matrix component binding material, the binding material being physically entrapped within a void volume in the fused high density polyethylene; an outlet portion configured to output the liquid sample from the liquid sample passageway that has passed through the filter plug , the outlet portion including a plunger section configured to receive a downward force into a sample vial to pressurize the liquid sample within the sample vial.
A transistor (TR), comprising: a substrate ; an active layer disposed on the substrate and including a first region , a second region , and a channel region between the first region and the second region; a gate electrode disposed on the active layer, the gate electrode overlapping the channel region; an insulating layer disposed on the gate electrode; a first electrode disposed on the insulating layer, the first electrode being electrically connected to the first region; a second electrode disposed on the insulating layer, the second electrode being electrically connected to the second region; and a first connection electrode (CE1) disposed on the substrate and electrically connecting the gate electrode and the second electrode, characterized in that a resistance of the first connection electrode is greater than a resistance of the gate electrode. a substrate ; an active layer disposed on the substrate and including a first region , a second region , and a channel region between the first region and the second region; a gate electrode disposed on the active layer, the gate electrode overlapping the channel region; an insulating layer disposed on the gate electrode; a first electrode disposed on the insulating layer, the first electrode being electrically connected to the first region; a second electrode disposed on the insulating layer, the second electrode being electrically connected to the second region; and a first connection electrode (CE1) disposed on the substrate and electrically connecting the gate electrode and the second electrode, characterized in that a resistance of the first connection electrode is greater than a resistance of the gate electrode.