A compound of Formula or a pharmaceutically acceptable salt thereof: wherein: X 1 is CR 1 or N; X 2 is CR 2 or N; X 3 is CR 3 or N; X 4 is CR 4 or N; each of R 1 , R 2 , R 3 , and R 4 is independently selected from hydrogen, halogen, C 1 -C 3 alkoxy, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs; each R 5 is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN, each of which is substituted with 0, 1, 2, or 3 R S ; each R 6 is independently selected from hydrogen, halogen, C 1 -C 3 alkyl, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs, or two R 6 groups are taken together to form an oxo; each R 7 is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN, each of which is substituted with 0, 1, 2, or 3 Rs; each R 8 is independently selected from hydrogen, hydroxyl, C 1 -C 3 alkyl, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs, or two R 8 groups are taken together to form an oxo; each R 9 is independently selected from hydrogen, C 1 -C 3 alkyl, -C(=O)-(C 1 -C 3 alkyl), -C(=O)-O-(C 1 -C 3 alkyl), and -C(=O)-NH-(C 1 -C 3 alkyl), each of which is substituted with 0, 1, 2, or 3 Rs, or two R 9 groups are taken together to form a 3- to 6-membered heterocycle or heteroaryl; each R S is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN; L is a linker of 1 to 16 carbon atoms in length, wherein one or more carbon atoms are optionally replaced by C(O), O, N(R 9 ), S, C 2 -alkenyl, C 2 -alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl, wherein the R 9 , C 2 -alkenyl, cycloalkyl, aryl, heterocycle, and heteroaryl are each independently substituted with 0, 1, 2, or 3 Rs; m is 0, 1, or 2; n is 0, 1, 2, or 3; and o is 0, 1, 2, or 3, wherein each hydrogen atom is independently and optionally replaced by a deuterium atom. X 1 is CR 1 or N; X 2 is CR 2 or N; X 3 is CR 3 or N; X 4 is CR 4 or N; each of R 1 , R 2 , R 3 , and R 4 is independently selected from hydrogen, halogen, C 1 -C 3 alkoxy, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs; each R 5 is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN, each of which is substituted with 0, 1, 2, or 3 R S ; each R 6 is independently selected from hydrogen, halogen, C 1 -C 3 alkyl, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs, or two R 6 groups are taken together to form an oxo; each R 7 is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN, each of which is substituted with 0, 1, 2, or 3 Rs; each R 8 is independently selected from hydrogen, hydroxyl, C 1 -C 3 alkyl, and C 1 -C 3 haloalkyl, each of which is substituted with 0, 1, 2, or 3 Rs, or two R 8 groups are taken together to form an oxo; each R 9 is independently selected from hydrogen, C 1 -C 3 alkyl, -C(=O)-(C 1 -C 3 alkyl), -C(=O)-O-(C 1 -C 3 alkyl), and -C(=O)-NH-(C 1 -C 3 alkyl), each of which is substituted with 0, 1, 2, or 3 Rs, or two R 9 groups are taken together to form a 3- to 6-membered heterocycle or heteroaryl; each R S is independently selected from halogen, hydroxyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 haloalkyl, -N(R 9 ) 2 , and -CN; L is a linker of 1 to 16 carbon atoms in length, wherein one or more carbon atoms are optionally replaced by C(O), O, N(R 9 ), S, C 2 -alkenyl, C 2 -alkynyl, cycloalkyl, aryl, heterocycle, or heteroaryl, wherein the R 9 , C 2 -alkenyl, cycloalkyl, aryl, heterocycle, and heteroaryl are each independently substituted with 0, 1, 2, or 3 Rs; m is 0, 1, or 2; n is 0, 1, 2, or 3; and o is 0, 1, 2, or 3, wherein each hydrogen atom is independently and optionally replaced by a deuterium atom. <EOS>