Magnetic Resonance Imaging apparatus for imaging an object, said Magnetic Resonance Imaging apparatus being configured for automatically detecting a brain tissue pathology in MR images of a patient, and comprising: - means for acquiring multiple MR imaging data and using said multiple MR imaging data for creating at least 4 different contrast maps of a patient brain; - means for performing, from said previously acquired multiple MR imaging data, an estimation of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) concentration for each voxel of at least a part of the patient brain and creating, from said estimation, GM, WM and CSF concentration maps for said part of the patient brain; - means for segmenting, from said previously acquired multiple MR imaging data, said part of the patient brain in different regions-of-interest (ROIs) according to a chosen atlas; - means for computing, for each voxel of each of the previously created contrast maps of the patient brain, and for at least said part of the patient brain, a deviation score zv obtained by combining voxel intensity of the contrast map in the patient brain, voxel tissues concentrations from the GM, WM and CSF concentration maps in the patient brain, and parameters values characterising a contrast map intensity distribution of each tissue in healthy controls obtained for the ROI to which said voxel belongs to, and means for creating from said deviation score and for each of the previously created quantitative contrast maps, a deviation map representing said part of the brain in function of the deviation score calculated for each voxel; - means for combining the previously obtained deviation maps into a single pathology map. - means for acquiring multiple MR imaging data and using said multiple MR imaging data for creating at least 4 different contrast maps of a patient brain; - means for performing, from said previously acquired multiple MR imaging data, an estimation of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) concentration for each voxel of at least a part of the patient brain and creating, from said estimation, GM, WM and CSF concentration maps for said part of the patient brain; - means for segmenting, from said previously acquired multiple MR imaging data, said part of the patient brain in different regions-of-interest (ROIs) according to a chosen atlas; - means for computing, for each voxel of each of the previously created contrast maps of the patient brain, and for at least said part of the patient brain, a deviation score zv obtained by combining voxel intensity of the contrast map in the patient brain, voxel tissues concentrations from the GM, WM and CSF concentration maps in the patient brain, and parameters values characterising a contrast map intensity distribution of each tissue in healthy controls obtained for the ROI to which said voxel belongs to, and means for creating from said deviation score and for each of the previously created quantitative contrast maps, a deviation map representing said part of the brain in function of the deviation score calculated for each voxel; - means for combining the previously obtained deviation maps into a single pathology map. <EOS>