Method for analyzing at least one chemical compound of a sample on a support after carrying out at least one metabolization process on the same support, comprising the following steps: I) Application of the sample to be analyzed comprising at least one chemical compound on a carrier in an application area of the carrier II) Contacting the carrier from step I) with at least one enzyme, enzyme system and/or cell system typical for the metabolization process, so that the metabolization process can take place and metabolization products can be formed III) Chromatographic separation of the at least one chemical compound present on the same carrier and/or the metabolization products from step II) along the carrier in a separation region, so that separation products are present in the separation region IV) Detection of the separation products from step III) by means of opto-mechanical, spectral or digital methods and/or by applying at least one microchemical detection reagent and/or by means of an assay to the separation region of the carrier or to specific carrier regions I) Evaluation of the detected separation products from step IV characterized in that the metabolization process is simulated by reaction with at least one enzyme typical of the metabolization process and/or at least one cell system typical of the metabolization process, and that the at least one enzyme typical for the metabolization process is selected from the group of hydrolases, isomerases, lyases, ligases, transferases and oxidoreductases, wherein the metabolization process is a metabolic process from the microbiome system or digestive tract from the mouth, stomach and intestinal region or gastrointestinal region (GIT) of vertebrates or a metabolic process from the liver. I) Application of the sample to be analyzed comprising at least one chemical compound on a carrier in an application area of the carrier II) Contacting the carrier from step I) with at least one enzyme, enzyme system and/or cell system typical for the metabolization process, so that the metabolization process can take place and metabolization products can be formed III) Chromatographic separation of the at least one chemical compound present on the same carrier and/or the metabolization products from step II) along the carrier in a separation region, so that separation products are present in the separation region IV) Detection of the separation products from step III) by means of opto-mechanical, spectral or digital methods and/or by applying at least one microchemical detection reagent and/or by means of an assay to the separation region of the carrier or to specific carrier regions I) Evaluation of the detected separation products from step IV characterized in that the metabolization process is simulated by reaction with at least one enzyme typical of the metabolization process and/or at least one cell system typical of the metabolization process, and that the at least one enzyme typical for the metabolization process is selected from the group of hydrolases, isomerases, lyases, ligases, transferases and oxidoreductases, wherein the metabolization process is a metabolic process from the microbiome system or digestive tract from the mouth, stomach and intestinal region or gastrointestinal region (GIT) of vertebrates or a metabolic process from the liver. <EOS>