A method, comprising: emitting a first wavelength of electromagnetic (EM) radiation (215/315) towards a biological tissue (230/330); receiving, at a plurality of receivers (120/220a-n/320a-n/420a-n) arranged in a spatial pattern, responses to the first wavelength of EM radiation after the first wavelength of EM radiation (215/315) interacts with the biological tissue (230/330); emitting a second wavelength of EM radiation (215/315) towards the biological tissue (230/330); receiving, at the plurality of receivers (120/220a-n/320a-n/420a-n), responses to the second wavelength of EM radiation after the second wavelength of EM radiation (215/315) interacts with the biological tissue (230/330); performing computer processing on first signals (510a-510n) representative of the received responses to the first wavelength of EM radiation and second signals (510a-510n) representative of the received responses to the second wavelength of EM radiation, characterised in that the processing includes: replicating and mixing the first signals (510a-510n) and the second signals (510a-510n) to generate a set of spectro-spatial responses (540a-540n); replicating and mixing the spectro-spatial responses (610a-610n) to generate a plurality of markers (640a-640n); and replicating and mixing the plurality of markers (710a-710n) and a plurality of user-selected markers to output a sequence (740a-740n) associated with characterization of the biological tissue; and wherein the user-selected markers include at least one of a tissue disease marker, a shape marker, a size marker, or some combination thereof. emitting a first wavelength of electromagnetic (EM) radiation (215/315) towards a biological tissue (230/330); receiving, at a plurality of receivers (120/220a-n/320a-n/420a-n) arranged in a spatial pattern, responses to the first wavelength of EM radiation after the first wavelength of EM radiation (215/315) interacts with the biological tissue (230/330); emitting a second wavelength of EM radiation (215/315) towards the biological tissue (230/330); receiving, at the plurality of receivers (120/220a-n/320a-n/420a-n), responses to the second wavelength of EM radiation after the second wavelength of EM radiation (215/315) interacts with the biological tissue (230/330); performing computer processing on first signals (510a-510n) representative of the received responses to the first wavelength of EM radiation and second signals (510a-510n) representative of the received responses to the second wavelength of EM radiation, characterised in that the processing includes: replicating and mixing the first signals (510a-510n) and the second signals (510a-510n) to generate a set of spectro-spatial responses (540a-540n); replicating and mixing the spectro-spatial responses (610a-610n) to generate a plurality of markers (640a-640n); and replicating and mixing the plurality of markers (710a-710n) and a plurality of user-selected markers to output a sequence (740a-740n) associated with characterization of the biological tissue; and wherein the user-selected markers include at least one of a tissue disease marker, a shape marker, a size marker, or some combination thereof. replicating and mixing the first signals (510a-510n) and the second signals (510a-510n) to generate a set of spectro-spatial responses (540a-540n); replicating and mixing the spectro-spatial responses (610a-610n) to generate a plurality of markers (640a-640n); and replicating and mixing the plurality of markers (710a-710n) and a plurality of user-selected markers to output a sequence (740a-740n) associated with characterization of the biological tissue; and wherein the user-selected markers include at least one of a tissue disease marker, a shape marker, a size marker, or some combination thereof. <EOS>