A trispecific antigen-binding molecule, wherein said molecule is an antigen-binding polypeptide dimer comprising a first polypeptide and a second polypeptide, each polypeptide having at least four antibody variable domains linked one after another, wherein (a) the first polypeptide comprises a first and a second antibody variable heavy domain (VH) linked with each other by a linker of 12 or less amino acid residues and a single chain Fv antigen binding unit having a third antibody variable heavy domain (VH) linked with an antibody variable light domain (VL), said third antibody variable heavy domain (VH) and antibody variable light domain (VL) are capable to associate to a first antigen binding site, wherein the first or second antibody variable heavy domain (VH) is linked with the single chain Fv antigen binding unit by a peptide linker; (b) the second polypeptide comprises a first and a second antibody variable light domain (VL) linked with each other by a linker of 12 or less amino acid residues and a single chain Fv antigen binding unit having a third antibody variable light domain (VL) linked with an antibody variable heavy domain (VH), said third antibody variable light domain (VL) and antibody variable heavy domain (VH) are capable to associate to a second antigen binding site, wherein the second antibody variable light domain (VL) is linked with the single chain Fv antigen binding unit by a peptide linker; (c) the first antibody variable heavy domain (VH) of the first polypeptide associates with the second antibody variable light domain (VL) of the second polypeptide to a third antigen binding site; (d) the second antibody variable heavy domain (VH) of the first polypeptide associates with the first antibody variable light domain (VL) of the second polypeptide to a fourth antigen binding site; and (e) two of said four antigen binding sites are specific for the same antigen. (a) the first polypeptide comprises a first and a second antibody variable heavy domain (VH) linked with each other by a linker of 12 or less amino acid residues and a single chain Fv antigen binding unit having a third antibody variable heavy domain (VH) linked with an antibody variable light domain (VL), said third antibody variable heavy domain (VH) and antibody variable light domain (VL) are capable to associate to a first antigen binding site, wherein the first or second antibody variable heavy domain (VH) is linked with the single chain Fv antigen binding unit by a peptide linker; (b) the second polypeptide comprises a first and a second antibody variable light domain (VL) linked with each other by a linker of 12 or less amino acid residues and a single chain Fv antigen binding unit having a third antibody variable light domain (VL) linked with an antibody variable heavy domain (VH), said third antibody variable light domain (VL) and antibody variable heavy domain (VH) are capable to associate to a second antigen binding site, wherein the second antibody variable light domain (VL) is linked with the single chain Fv antigen binding unit by a peptide linker; (c) the first antibody variable heavy domain (VH) of the first polypeptide associates with the second antibody variable light domain (VL) of the second polypeptide to a third antigen binding site; (d) the second antibody variable heavy domain (VH) of the first polypeptide associates with the first antibody variable light domain (VL) of the second polypeptide to a fourth antigen binding site; and (e) two of said four antigen binding sites are specific for the same antigen. <EOS>