A compound selected from: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of each thereof, wherein R 1 is: hydrogen, -N 3 , CN, NR 21 R 22 , -OR 23 , -SO 2 (C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl; each R 21 and R 22 independently is hydrogen, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, or -SO 2 (C 1 -C 6 alkyl); or R 21 and R 22 together with the nitrogen atom they are bonded to form a 4-15 membered heterocycle or a 5-15 membered heteroaryl; R 23 is hydrogen, C 1 -C 6 alkyl; R 2 is hydrogen or halo; R 3 is hydrogen; R 4 is hydrogen, halo, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, or C 6 -C 10 aryl, R 5 , R 9 , R 12 , and R 15 independently are hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl; or R 4 and R 5 together with the intervening carbon atoms between them form a C 5 -C 6 cycloalkyl ring; R 7 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, or a 5-15 membered heteroaryl; R 6 and R 10 independently are hydrogen or halo; R 8 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or 5-15 membered heteroaryl, such that R 8 and R 9 do not both represent hydrogen; each R 11 independently is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, or C 6 -C 10 aryl; R 13 , R 14 , R 16 , and R 17 are independently hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkyny, or C 1 -C 6 alkoxy; wherein the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, heteroaryl, alkoxy and ether groups are optionally substituted. R 1 is: hydrogen, -N 3 , CN, NR 21 R 22 , -OR 23 , -SO 2 (C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl; each R 21 and R 22 independently is hydrogen, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, or -SO 2 (C 1 -C 6 alkyl); or R 21 and R 22 together with the nitrogen atom they are bonded to form a 4-15 membered heterocycle or a 5-15 membered heteroaryl; R 23 is hydrogen, C 1 -C 6 alkyl; R 2 is hydrogen or halo; R 3 is hydrogen; R 4 is hydrogen, halo, C 1 -C 6 alkoxy, C 1 -C 6 alkyl, or C 6 -C 10 aryl, R 5 , R 9 , R 12 , and R 15 independently are hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl; or R 4 and R 5 together with the intervening carbon atoms between them form a C 5 -C 6 cycloalkyl ring; R 7 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 4-15 membered heterocycle, or a 5-15 membered heteroaryl; R 6 and R 10 independently are hydrogen or halo; R 8 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or 5-15 membered heteroaryl, such that R 8 and R 9 do not both represent hydrogen; each R 11 independently is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl, or C 6 -C 10 aryl; R 13 , R 14 , R 16 , and R 17 are independently hydrogen, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkyny, or C 1 -C 6 alkoxy; <EOS>