A compound of Formula Ia, or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, halogen, cyano, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 2-6 alkenyl, an optionally substituted C 2-6 alkynyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl, NR 10 R 11 , COOR 12 , CONR 13 R 14 , CN, S(O) n R 15 , or OR 16 ; wherein R 10 and R 11 are each independently hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 1-6 alkanoyl, an optionally substituted C 3-6 cycloalkanoyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl, COOR 12 , or CONR 13 R 14 ; R 12 , R 13 and R 14 are each independently hydrogen or an optionally substituted C 1-6 alkyl; n is 0, 1, or 2; R 15 is an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or NR 10 R 11 ; R 16 is hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 1-6 alkanoyl, an optionally substituted C 3-6 cycloalkanoyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl or CONR 13 R 14 ; and R 3 is an optionally substituted C 6-10 aryl or optionally substituted 5 to 10 membered heteroaryl, provided that when R 1 is hydrogen, then R 3 is not an optionally substituted phenyl. R 1 is hydrogen, halogen, cyano, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 2-6 alkenyl, an optionally substituted C 2-6 alkynyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl, NR 10 R 11 , COOR 12 , CONR 13 R 14 , CN, S(O) n R 15 , or OR 16 ; wherein R 10 and R 11 are each independently hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 1-6 alkanoyl, an optionally substituted C 3-6 cycloalkanoyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl, COOR 12 , or CONR 13 R 14 ; R 12 , R 13 and R 14 are each independently hydrogen or an optionally substituted C 1-6 alkyl; n is 0, 1, or 2; R 15 is an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or NR 10 R 11 ; R 16 is hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, an optionally substituted C 1-6 alkanoyl, an optionally substituted C 3-6 cycloalkanoyl, an optionally substituted C 6-10 aryl, an optionally substituted 5-10 membered heteroaryl, an optionally substituted 4-6 membered heterocyclyl or CONR 13 R 14 ; and R 3 is an optionally substituted C 6-10 aryl or optionally substituted 5 to 10 membered heteroaryl, provided that when R 1 is hydrogen, then R 3 is not an optionally substituted phenyl. <EOS>