mhurhangee/patent-ind-claim-en huggingface dataset:
A waterproof structure provided at a ventilation opening formed on a top surface of a housing of electronic equipment, the water proof structure comprising a first filter mounted to the ventilation opening to be inclined in a depth direction (D) or a width direction (W) of the housing wherein the first filter comprises a hydromesh layer having a hydrophobic or a water-repellent property and breathability, characterized in: that the waterproof structure for the ventilation opening of the electronic equipment further comprises a gutter portion extending below a downslope edge of the first filter along the downslope edge, and that the gutter portion is configured to receive moisture flowing down from a surface of the first filter and to discharge the moisture in an extending direction of the gutter portion . that the waterproof structure for the ventilation opening of the electronic equipment further comprises a gutter portion extending below a downslope edge of the first filter along the downslope edge, and that the gutter portion is configured to receive moisture flowing down from a surface of the first filter and to discharge the moisture in an extending direction of the gutter portion .
A gas concentration measurement device comprising: a light source that emits infrared light; a band pass filter ; a detector that detects the infrared light from the light source through the band pass filter; and a waveguide member including a wave-guiding portion having a tubular inner peripheral surface, an entrance portion that is formed at one side of the wave-guiding portion and through which the infrared light from the light source is introduced, and an exit portion that is formed at the other side of the wave-guiding portion and configured to guide the infrared light that has passed through the wave-guiding portion toward the band pass filter and subsequently to the detector, wherein a portion or entirety of the inner peripheral surface of the wave-guiding portion includes a tapered region having a cross section that decreases along a longitudinal axis direction from the entrance portion to the exit portion, wherein the tapered region of the inner peripheral surface of the wave-guiding portion includes a first curved portion (93A, 93B1); the first curved portion having a curvature in the longitudinal axis direction from the entrance portion to the exit portion and a cross section that decreases along the longitudinal axis direction from the entrance portion to the exit portion; and wherein the waveguide member is configured to reflect the infrared light that has entered the wave-guiding portion through the entrance portion in the tapered region, so that energy of the infrared light that is obliquely incident on the band pass filter is reduced. a light source that emits infrared light; a band pass filter ; a detector that detects the infrared light from the light source through the band pass filter; and a waveguide member including a wave-guiding portion having a tubular inner peripheral surface, an entrance portion that is formed at one side of the wave-guiding portion and through which the infrared light from the light source is introduced, and an exit portion that is formed at the other side of the wave-guiding portion and configured to guide the infrared light that has passed through the wave-guiding portion toward the band pass filter and subsequently to the detector, wherein a portion or entirety of the inner peripheral surface of the wave-guiding portion includes a tapered region having a cross section that decreases along a longitudinal axis direction from the entrance portion to the exit portion, wherein the tapered region of the inner peripheral surface of the wave-guiding portion includes a first curved portion (93A, 93B1); the first curved portion having a curvature in the longitudinal axis direction from the entrance portion to the exit portion and a cross section that decreases along the longitudinal axis direction from the entrance portion to the exit portion; and wherein the waveguide member is configured to reflect the infrared light that has entered the wave-guiding portion through the entrance portion in the tapered region, so that energy of the infrared light that is obliquely incident on the band pass filter is reduced.
A liquid-phase process for the production of H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 of formula (I), in the form of the acetic acid salt, which comprises the following steps: - coupling compound (II) H-Phe-NH 2 : with compound (III) Boc-Lys(Z)-OH: to obtain a compound of formula (IV), Boc-Lys(Z)-Phe-NH 2 : - reacting compound (IV) with methanesulfonic acid (V) MeSO 3 H (V) to obtain the free amine salt (VI) MeSO 3 H.H-Lys(Z)-Phe-NH 2 : - reacting the salt (VI) with the protected amino acid Boc-Dmt(Bzl)-OH (VII) to obtain the protected tripeptide (VIII): - treating the compound (VIII) with methanesulfonic acid (V) to obtain the corresponding salt (IX), MeSO 3 .H-Dmt(Bzl)-Lys(Z)-Phe-NH 2 : - coupling the acid salt (IX) with Z-D-Arg-ONa (X) to form the protected tetrapeptide (XI), Z-D-Arg-Dmt(Bzl)-Lys(Z)-Phe-NH 2 : and - deprotecting compound (XI) by hydrogenolysis to obtain the tetrapetide H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 (I) and further salifying it with acetic acid to form the corresponding salt. - coupling compound (II) H-Phe-NH 2 : with compound (III) Boc-Lys(Z)-OH: to obtain a compound of formula (IV), Boc-Lys(Z)-Phe-NH 2 : - reacting compound (IV) with methanesulfonic acid (V) MeSO 3 H (V) to obtain the free amine salt (VI) MeSO 3 H.H-Lys(Z)-Phe-NH 2 : - reacting the salt (VI) with the protected amino acid Boc-Dmt(Bzl)-OH (VII) to obtain the protected tripeptide (VIII): - treating the compound (VIII) with methanesulfonic acid (V) to obtain the corresponding salt (IX), MeSO 3 .H-Dmt(Bzl)-Lys(Z)-Phe-NH 2 : - coupling the acid salt (IX) with Z-D-Arg-ONa (X) to form the protected tetrapeptide (XI), Z-D-Arg-Dmt(Bzl)-Lys(Z)-Phe-NH 2 : and - deprotecting compound (XI) by hydrogenolysis to obtain the tetrapetide H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH 2 (I) and further salifying it with acetic acid to form the corresponding salt.
Use of a kit in the in vitro detection or diagnosis of breast cancer, comprising nucleic acid(s) capable of specifically binding to a polynucleotide of a breast cancer markers: miR-4783-3p.
A compound of formula (I) in which: R 1 represents methyl, ethyl, trifluoromethyl, 2,2-difluoroethyl, cyano, bromo, methoxy, or difluoromethoxy, or chloro with the proviso that when R 1 is chloro, then R 2 represents hydrogen or chloro and R 3 and R 4 represent hydrogen; R 2 represents hydrogen, methyl, fluoro, chloro or bromo; R 3 represents hydrogen or fluoro; R 4 represents hydrogen or fluoro, wherein at least one of R 3 and R 4 represents hydrogen; R 5 represents C 2 -C 5 -alkyl, which is substituted once with hydroxy, C 1 -C 4 -alkoxy, R 7 R 8 N-, or phenyl, or R 6 -CH 2 -, wherein said phenyl groups are optionally substituted one or more times, independently of each other, with R'; R' represents, independently of each other, hydroxy, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl or C 1 -C 4 -haloalkoxy; R 6 represents a group selected from the group: wherein * indicates the point of attachment of said group with the rest of the molecule; R 7 , R 8 represent, independently of each other, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl or R 7 and R 8 together with the nitrogen atom to which they are attached form a 5- to 6-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom or heteroatom containing group selected from O and NR 10 ; R 9 represents hydrogen, C 1 -C 3 -alkyl or C 1 -C 3 -haloalkyl; R 10 represents hydrogen or C 1 -C 3 -alkyl; or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer. R 1 represents methyl, ethyl, trifluoromethyl, 2,2-difluoroethyl, cyano, bromo, methoxy, or difluoromethoxy, or chloro with the proviso that when R 1 is chloro, then R 2 represents hydrogen or chloro and R 3 and R 4 represent hydrogen; R 2 represents hydrogen, methyl, fluoro, chloro or bromo; R 3 represents hydrogen or fluoro; R 4 represents hydrogen or fluoro, wherein at least one of R 3 and R 4 represents hydrogen; R 5 represents C 2 -C 5 -alkyl, which is substituted once with hydroxy, C 1 -C 4 -alkoxy, R 7 R 8 N-, or phenyl, or R 6 -CH 2 -, wherein said phenyl groups are optionally substituted one or more times, independently of each other, with R'; R' represents, independently of each other, hydroxy, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl or C 1 -C 4 -haloalkoxy; R 6 represents a group selected from the group: wherein * indicates the point of attachment of said group with the rest of the molecule; R 7 , R 8 represent, independently of each other, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl or R 7 and R 8 together with the nitrogen atom to which they are attached form a 5- to 6-membered nitrogen containing heterocyclic ring, optionally containing one additional heteroatom or heteroatom containing group selected from O and NR 10 ; R 9 represents hydrogen, C 1 -C 3 -alkyl or C 1 -C 3 -haloalkyl; R 10 represents hydrogen or C 1 -C 3 -alkyl;
A radar-based fill level measuring device for measuring a fill level of a filling material located in a container , comprising: - a signal generating unit that is configured to generate an electrical high frequency signal (s HF ) based on an adjustable measurement rate (r m ), - an antenna arrangement , which can be used to transmit the high frequency signal (s HF ) toward the filling material as a radar signal (s HF ) and can then, following reflection on the surface of the filling material , be received as a corresponding reception signal (e HF ), - an evaluation unit that is configured to cyclically redetermine the fill level (L) at least on the basis of the reception signal (e HF ) at the adjustable measurement rate (r m ), - a temperature sensor that is configured to measure the temperature on the signal generating unit and/or on the evaluation unit , characterized in that the signal generating unit and the evaluation unit are configured to regulate the measurement rate (r m ) in such a way on the basis of the measured temperature that the measurement rate (r m ) is at least reduced above a defined limit temperature (T g ) as the temperature increases, and that the signal generating unit and the evaluation unit are configured to stop the fill level measurement insofar as the measured temperature exceeds a predefined maximum temperature (T max ). - a signal generating unit that is configured to generate an electrical high frequency signal (s HF ) based on an adjustable measurement rate (r m ), - an antenna arrangement , which can be used to transmit the high frequency signal (s HF ) toward the filling material as a radar signal (s HF ) and can then, following reflection on the surface of the filling material , be received as a corresponding reception signal (e HF ), - an evaluation unit that is configured to cyclically redetermine the fill level (L) at least on the basis of the reception signal (e HF ) at the adjustable measurement rate (r m ), - a temperature sensor that is configured to measure the temperature on the signal generating unit and/or on the evaluation unit , the signal generating unit and the evaluation unit are configured to regulate the measurement rate (r m ) in such a way on the basis of the measured temperature that the measurement rate (r m ) is at least reduced above a defined limit temperature (T g ) as the temperature increases, and that the signal generating unit and the evaluation unit are configured to stop the fill level measurement insofar as the measured temperature exceeds a predefined maximum temperature (T max ).
A system for capturing target components of interest from a liquid, comprising: a motorized turntable ; a speed controller to control the rotational velocity of the motorized turntable ; a plurality of magnets arranged in a first Halbach array, the first Halbach array located on the motorized turntable and concentric with the axis of the motorized turntable so as to rotate circumferentially about the outer circumference of a sample conduit; the sample conduit having an input port and an output port and having an outer wall defining a lumen, the sample conduit positioned within and concentric with the axis of the first Halbach array; and a liquid containing a plurality of magnetic particles flowing through the sample conduit from the input port to the output port, wherein each individual magnetic particle is bound to a ligand that is unique to the target components of interest in the sample, wherein, in operation, the magnetic field of the first Halbach array has a strength and an angular velocity of rotation adjusted such that the magnetic particles form chains of magnetic particles within the liquid , so that the target components of interest are captured by the ligands bound to the magnetic particles . a motorized turntable ; a speed controller to control the rotational velocity of the motorized turntable ; a plurality of magnets arranged in a first Halbach array, the first Halbach array located on the motorized turntable and concentric with the axis of the motorized turntable so as to rotate circumferentially about the outer circumference of a sample conduit; the sample conduit having an input port and an output port and having an outer wall defining a lumen, the sample conduit positioned within and concentric with the axis of the first Halbach array; and a liquid containing a plurality of magnetic particles flowing through the sample conduit from the input port to the output port, wherein each individual magnetic particle is bound to a ligand that is unique to the target components of interest in the sample, wherein, in operation, the magnetic field of the first Halbach array has a strength and an angular velocity of rotation adjusted such that the magnetic particles form chains of magnetic particles within the liquid , so that the target components of interest are captured by the ligands bound to the magnetic particles .
A humanized or human anti-PD-L1 antibody that inhibits the interaction between PD-1 and PD-L1 for use in treating cancer in humans, wherein the anti-PD-L1 antibody inhibits the immunosuppressive signal of PD-1.
A cross-linkable rubber composition, the cross-linkable rubber composition comprising, per hundred parts by weight of rubber (phr): ≥ 1 phr to ≤ 100 phr of a rubber component selected from the group of styrene-butadiene rubber (SBR), polybutadiene rubber (BR), natural rubber (NR) or a mixture thereof; wherein the composition further comprises ≥ 1 phr to ≤ 50 phr of a thermoplastic elastomer (TPE) with a glass transition temperature of ≥ -30 °C (measured by DSC, according to ISO 22768) and further comprises an at least partially aliphatic resin component, wherein the TPE is selected from the group consisting of diblock or triblock copolymers which are linear or star-branched selected from styrene/butadiene (SB), styrene/isoprene (SI), styrene/butadiene/isoprene (SBI), styrene/butadiene/styrene (SBS), styrene/isoprene/styrene (SIS), styrene/butadiene/isoprene/styrene (SBIS) and the mixtures of these copolymers and wherein the resin component comprises a polyterpene resin, C5 resin, dicyclopentadiene (DCPD) or terpene phenolic resin. ≥ 1 phr to ≤ 100 phr of a rubber component selected from the group of styrene-butadiene rubber (SBR), polybutadiene rubber (BR), natural rubber (NR) or a mixture thereof; wherein the composition further comprises ≥ 1 phr to ≤ 50 phr of a thermoplastic elastomer (TPE) with a glass transition temperature of ≥ -30 °C (measured by DSC, according to ISO 22768) and further comprises an at least partially aliphatic resin component, wherein the TPE is selected from the group consisting of diblock or triblock copolymers which are linear or star-branched selected from styrene/butadiene (SB), styrene/isoprene (SI), styrene/butadiene/isoprene (SBI), styrene/butadiene/styrene (SBS), styrene/isoprene/styrene (SIS), styrene/butadiene/isoprene/styrene (SBIS) and the mixtures of these copolymers and wherein the resin component comprises a polyterpene resin, C5 resin, dicyclopentadiene (DCPD) or terpene phenolic resin.
A conductive concentrated resin composition, comprising: (a) 100 parts by weight of a base resin comprising 60 to 85 % by weight of a polyamide resin, 3 to 15 % by weight of a polar polymer, and 5 to 25 % by weight of a non-polar polymer; (b) 15 to 25 parts by weight of a carbon nanofibril; (c) 1 to 4 parts by weight of a carbon nanoplate; and (d) 1 to 3 parts by weight of a nanosilicate. (a) 100 parts by weight of a base resin comprising 60 to 85 % by weight of a polyamide resin, 3 to 15 % by weight of a polar polymer, and 5 to 25 % by weight of a non-polar polymer; (b) 15 to 25 parts by weight of a carbon nanofibril; (c) 1 to 4 parts by weight of a carbon nanoplate; and (d) 1 to 3 parts by weight of a nanosilicate.
A method for estimating a braking factor (k brk ) for a braking system for a vehicle, wherein the braking factor (k brk ) is estimated by applying the following equation: k brk = a + b * v veh + c * p brk + d * T brk + f * p brk 2 , wherein a, b, c, d and f are model parameters, v veh is a velocity of the vehicle, p brk is a braking pressure , and T brk is a brake temperature.
A bioelectrode comprising a silver coating layer provided on a conductive silicone rubber electrode, wherein the conductive silicone rubber electrode is composed of a silicone rubber containing conductive carbon particles, the silver coating layer is composed of silicone rubber and at least one of agglomerated silver powder and flake-like silver powder, characterized in that the silver coating layer has a thickness of 18 μm to 80 μm. the conductive silicone rubber electrode is composed of a silicone rubber containing conductive carbon particles, the silver coating layer is composed of silicone rubber and at least one of agglomerated silver powder and flake-like silver powder, characterized in that the silver coating layer has a thickness of 18 μm to 80 μm.
A method for controlling foam comprising: providing a food composition comprising a foam control agent and a foodstuff, the foam control agent comprising a composition shown in Equation wherein each of R 1 , R 2 , R 3 are independently hydrogen, alkyl, or aryl alkyl, and m is 1 to 3; processing the food composition, wherein the foodstuff comprises potato derivatives or beet derivatives. providing a food composition comprising a foam control agent and a foodstuff, the foam control agent comprising a composition shown in Equation wherein each of R 1 , R 2 , R 3 are independently hydrogen, alkyl, or aryl alkyl, and m is 1 to 3; wherein each of R 1 , R 2 , R 3 are independently hydrogen, alkyl, or aryl alkyl, and m is 1 to 3; processing the food composition, wherein the foodstuff comprises potato derivatives or beet derivatives.
A method for producing a 3D item on a receiver plate having an x-y plane by means of fused deposition modelling, the 3D item comprising one or more layers of 3D printed material , a first layer part of the one or more layers comprising a first strand of first 3D printed material in a first plane and a second strand of second 3D printed material in a second plane, the first plane and the second plane being parallel to the x-y-plane of the receiver plate, at least one of the first 3D printed material and the second 3D printed material being transmissive for visible light, wherein the method comprises a 3D printing stage comprising layer-wise depositing 3D printable material to provide the 3D item , wherein, during the 3D printing stage, the first strand of first 3D printed material and the second strand of second 3D printed material are deposited so that at a plurality of positions in a cross-sectional view parallel to the first plane and the second plane, the first strand and the second strand are available in a configuration wherein the first strand and the second strand are next to each other, either in direct contact or at a non-zero distance, and wherein, at one or more first positions within the first layer part , the arrangement of the first strand and the second strand is swapped relative to each other during 3D printing. wherein the method comprises a 3D printing stage comprising layer-wise depositing 3D printable material to provide the 3D item , wherein, during the 3D printing stage, the first strand of first 3D printed material and the second strand of second 3D printed material are deposited so that at a plurality of positions in a cross-sectional view parallel to the first plane and the second plane, the first strand and the second strand are available in a configuration wherein the first strand and the second strand are next to each other, either in direct contact or at a non-zero distance, and wherein, at one or more first positions within the first layer part , the arrangement of the first strand and the second strand is swapped relative to each other during 3D printing.
A drum cartridge comprising: a drum frame to which a developing cartridge is detachably attachable, the developing cartridge including a storage medium having an electrical contact surface ; a photosensitive drum rotatable about a first axis (A1) extending in a first direction, the photosensitive drum being positioned at a first end portion of the drum frame in a second direction; a transfer roller rotatable about a second axis (A2) extending in the first direction, the transfer roller being in contact with a surface of the photosensitive drum; and a conveying roller rotatable about a third axis (A3) extending in the first direction, the conveying roller being separated from the transfer roller in the second direction, characterized in that the drum frame has a first opening , the first opening being positioned between the transfer roller and the conveying roller in the second direction, the configuration is such that the electrical contact surface is exposed to an outside of the drum frame through the first opening in a case where the developing cartridge is attached to the drum frame. a drum frame to which a developing cartridge is detachably attachable, the developing cartridge including a storage medium having an electrical contact surface ; a photosensitive drum rotatable about a first axis (A1) extending in a first direction, the photosensitive drum being positioned at a first end portion of the drum frame in a second direction; a transfer roller rotatable about a second axis (A2) extending in the first direction, the transfer roller being in contact with a surface of the photosensitive drum; and a conveying roller rotatable about a third axis (A3) extending in the first direction, the conveying roller being separated from the transfer roller in the second direction, characterized in that the drum frame has a first opening , the first opening being positioned between the transfer roller and the conveying roller in the second direction, the configuration is such that the electrical contact surface is exposed to an outside of the drum frame through the first opening in a case where the developing cartridge is attached to the drum frame.