mhurhangee/patent-ind-claim-en huggingface dataset:
A method of producing an antibody, or an antigen binding fragment thereof, that binds to CLDN6 associated with the surface of a cell that expresses CLDN6 and that does not detectably bind to CLDN9 associated with the surface of a cell that expresses CLDN9, the method comprising the steps of: (a) culturing a host cell transformed to express the antibody or antigen binding fragment thereof; and (b) isolating the antibody or antigen binding fragment thereof expressed by the host cell; wherein the transformed host cell comprises: (i) a nucleic acid sequence encoding a polypeptide comprising the antibody heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 26-33, positions 51-58, and positions 97-106 of SEQ ID NO: 36, respectively, or a variant thereof; and a nucleic acid sequence encoding a polypeptide comprising the antibody light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 27-31, positions 49-51, and positions 88-97 of SEQ ID NO: 35, respectively, or a variant thereof, wherein the variant comprises heavy chain CDR1, CDR2, and CDR3 regions having amino acid sequences according to SEQ ID NOs: 47, 48, and 46, respectively, and light chain CDR1, CDR2, and CDR3 regions having amino acid sequences according to SEQ ID NOs: 52, 53, and 51, respectively wherein binding of the antibody to CLDN6 and CLDN9 is determined by flow cytometry analysis as binding of the antibody to CLDN6 and CLDN9 expressed on the surface of intact cells. (a) culturing a host cell transformed to express the antibody or antigen binding fragment thereof; and (b) isolating the antibody or antigen binding fragment thereof expressed by the host cell; (i) a nucleic acid sequence encoding a polypeptide comprising the antibody heavy chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 26-33, positions 51-58, and positions 97-106 of SEQ ID NO: 36, respectively, or a variant thereof; and a nucleic acid sequence encoding a polypeptide comprising the antibody light chain CDR1, CDR2, and CDR3 regions having the amino acid sequences of positions 27-31, positions 49-51, and positions 88-97 of SEQ ID NO: 35, respectively, or a variant thereof,
A method for the additive manufacture of a three-dimensional physical object at a pre-determined formation site , in which a first polymer, whose monomer units comprise first reactive side groups amenable to coupling, and a second polymer, whose monomer units comprise second reactive side groups amenable to coupling, are crosslinked with one another to give the physical object, wherein the first polymer and the second polymer are introduced with the aid of a metering device into an alternating-current electric field, characterised in that the alternating-current electric field is generated between at least one first electrode , which is arranged in the region of an outlet aperture of the metering device , and at least one second electrode , which is arranged at a distance from the first electrode in the region of the outlet aperture of the orifice space or in the region of the pre-determined formation site of the physical object, wherein the voltage, the frequency, the current intensity and the field energy intensity of the alternating-current electric field are selected in such a way that the first reactive side groups of the first polymer and the second reactive side groups of the second polymer become bonded to one another via an electrostrictively assisted chemical reaction.
An electrostatic capacitance fluid level sensor including a hermetic terminal having a metal base and two electrically conductive terminal pins inserted through the metal base to be hermetically insulated and fixed by an electrically insulating filler and two electrodes provided on the hermetic terminal for detection of fluid level by electrostatic capacitance, wherein the sensor further comprising: a detection unit including two electrodes and electrically insulating spacers fixing a positional relationship between the electrodes ; and two connecting terminals configured to connect and fix the two electrodes to the two conductive terminal pins respectively, wherein at least one of the two connecting terminals is deformable by a weaker force than a force causing the electrodes to deform. a detection unit including two electrodes and electrically insulating spacers fixing a positional relationship between the electrodes ; and two connecting terminals configured to connect and fix the two electrodes to the two conductive terminal pins respectively, wherein at least one of the two connecting terminals is deformable by a weaker force than a force causing the electrodes to deform.
A saddle-stitch book binding system comprising: a conveying device conveying sheets of paper along a conveying path; a cut paper supply device or a folding device or a cutter connected to an upstream end of the conveying path; a collator arranged on the intermediate portion of the conveying path; a saddle stitching device connected to a downstream end of the conveying path; and a controller integrally controlling the cut paper supply device or the folding device or the cutter and the collator and the saddle stitching device, characterised in that the collator can switch between a non-operating mode, a first operating mode in which the collator operates as such collator and in which first operating mode the cut paper supplying device or folding device or cutter is stopped and a second operating mode in which the collator operates as an additional sheet supplying device. a conveying device conveying sheets of paper along a conveying path; a cut paper supply device or a folding device or a cutter connected to an upstream end of the conveying path; a collator arranged on the intermediate portion of the conveying path; a saddle stitching device connected to a downstream end of the conveying path; and a controller integrally controlling the cut paper supply device or the folding device or the cutter and the collator and the saddle stitching device, characterised in that the collator can switch between a non-operating mode, a first operating mode in which the collator operates as such collator and in which first operating mode the cut paper supplying device or folding device or cutter is stopped and a second operating mode in which the collator operates as an additional sheet supplying device.
A method of conducting a fitting session for fitting a hearing device (HD) to a hearing device user's (U) needs, the hearing device comprising an input transducer (IT) for picking up sound in the environment of the user (U) and providing an electric input signal(IN), and an output transducer (OT) for providing output stimuli perceivable to the user (U) as sound based on a processed version (OUT) of said electric input signal (IN), the method comprising S1. providing an estimate of a current feedback from said output transducer to said input transducer, while the hearing device is in an operational state; S2. evaluating said estimate of a current feedback and providing a value of a feedback risk indicator in dependence of said estimate of a current feedback; S3. determining whether said value of the feedback risk indicator fulfils a high-risk criterion, a fulfilment of said high-risk criterion being dependent of said estimate of the current feedback; and S4. if said high-risk criterion is fulfilled providing at least one of a warning and a recommendation to a hearing care professional (HCP) and/or to the user (U) in relation to said feedback risk; wherein steps S1 to S4 are configured to be automatically performed as background processes, said background processes being executed by a computer without a user's active involvement, and wherein step S3 of determining whether said value of the feedback risk indicator fulfils a high-risk criterion comprises one or more logical operations related to the estimate of a current feedback (H est ). S1. providing an estimate of a current feedback from said output transducer to said input transducer, while the hearing device is in an operational state; S2. evaluating said estimate of a current feedback and providing a value of a feedback risk indicator in dependence of said estimate of a current feedback; S3. determining whether said value of the feedback risk indicator fulfils a high-risk criterion, a fulfilment of said high-risk criterion being dependent of said estimate of the current feedback; and S4. if said high-risk criterion is fulfilled providing at least one of a warning and a recommendation to a hearing care professional (HCP) and/or to the user (U) in relation to said feedback risk; wherein steps S1 to S4 are configured to be automatically performed as background processes, said background processes being executed by a computer without a user's active involvement, and wherein step S3 of determining whether said value of the feedback risk indicator fulfils a high-risk criterion comprises one or more logical operations related to the estimate of a current feedback (H est ).
Spring wire manufactured from a steel, which consists of, in % by weight: C: 0.35 - 0.42%, Si: 1.5 - 1.8%, Mn: 0.5 - 0.8%, Cr: 0.05 - 0.25%, Nb: 0.020 - 0.10%, V: 0.020 - 0.10%, N: 0.0040 - 0.0120%, AL: ≤ 0.03%, and the remainder of iron and unavoidable impurities, wherein the total content of impurities is limited to at most 0.2% and the impurities include up to 0.025% P and 0.025% S.
A production method of a structured ceramic tile, comprising, in succession, steps of: - carrying out forming of an unfired tile starting from a suitable mixture; - carrying out drying of the formed unfired tile; - carrying out firing of the dried tile; comprising, between the step of forming the tile and the step of firing the tile, steps of: - applying a covering on a surface of the tile so that at least a protection region of the surface is defined, covered by the covering and inaccessible from outside, and at least a working region of the surface is defined, accessible from outside; and thereafter - dispensing, on the surface of the tile, fragments of an abrasive material, so as to abrade the working region; and thereafter - removing the covering from the surface of the tile; characterised in that : the step of applying at least a covering on the surface of the tile consists of applying a layer of adhesive or wax on the surface of the tile so that the layer of adhesive or wax adheres to the surface and can subsequently be removed, to define the protection region and the working region. - carrying out forming of an unfired tile starting from a suitable mixture; - carrying out drying of the formed unfired tile; - carrying out firing of the dried tile; - applying a covering on a surface of the tile so that at least a protection region of the surface is defined, covered by the covering and inaccessible from outside, and at least a working region of the surface is defined, accessible from outside; and thereafter - dispensing, on the surface of the tile, fragments of an abrasive material, so as to abrade the working region; and thereafter - removing the covering from the surface of the tile; characterised in that : the step of applying at least a covering on the surface of the tile consists of applying a layer of adhesive or wax on the surface of the tile so that the layer of adhesive or wax adheres to the surface and can subsequently be removed, to define the protection region and the working region.
A method for producing a molded material , the molded material comprising: a tubular body and a flange formed at an end portion of the body , the molded material being produced by performing at least two molding processes on a base metal sheet , wherein the at least two molding processes comprise at least one drawing-out process and at least one drawing process performed after the drawing-out process; wherein the drawing-out process is carried out using a mold that comprises a punch and a die having a pushing hole to form a first intermediate body ; wherein a first drawing process among the at least one drawing process is carried out using a mold comprising a die and a drawing sleeve ; and wherein the first drawing process is carried out on a region corresponding to the body of the molded material , while a gap between the die and the drawing sleeve is open so that the outer edge of the first intermediate body is not sandwiched; and wherein an ironing process is performed on a region corresponding to the flange of the molded material , while keeping a constant interval of a mold gap between the die and the drawing sleeve that is set to sandwich the region corresponding to the flange , wherein an ironing ratio of the ironing process is set so as to be less than the thickness of the flange ; at more than 0%, and 50% or less, wherein the ironing ratio is calculated by the following equation: Ironing Ratio % = Sheet thickness before ironing − Sheet thickness after ironing Sheet thickness before ironing × 100 .
A variable coding method for realizing chip reuse, comprising the following steps: using at least two identical integrated circuit chips, each of the at least two identical integrated circuit chips is an RF switch chip for switching high band (HB) RF signals or low band (LB) RF signals and comprising two different control logic truth tables on the same chip; each of the at least two identical integrated circuit chips receiving same logic input signals (VC1-VC4) and a logic control signal (Vctrl) connected by wire bonding to a VDD end or a GND end, to execute a high band (HB) logic truth table decoding function when the logic control signal (Vctrl) is connected to the VDD end, or to execute a low band (LB) logic truth table decoding function when the logic control signal (Vctrl) is connected to the GND end. using at least two identical integrated circuit chips, each of the at least two identical integrated circuit chips is an RF switch chip for switching high band (HB) RF signals or low band (LB) RF signals and comprising two different control logic truth tables on the same chip; each of the at least two identical integrated circuit chips receiving same logic input signals (VC1-VC4) and a logic control signal (Vctrl) connected by wire bonding to a VDD end or a GND end, to execute a high band (HB) logic truth table decoding function when the logic control signal (Vctrl) is connected to the VDD end, or to execute a low band (LB) logic truth table decoding function when the logic control signal (Vctrl) is connected to the GND end.
A detector for determining a position of at least one object , the detector comprising: - at least one optical sensor , the optical sensor being configured to detect at least one light spot generated by at least one light beam propagating from the object towards the detector , the optical sensor having at least one matrix of pixels , each pixel being adapted to generate at least one pixel signal s i,j in response to an illumination of the pixel by the light beam ; - at least one non-linearization device configured to transform the pixel signals s i,j of all pixels i, j or of at least one group of pixels into nonlinear pixel signals s' i,j , the nonlinear pixel signals s' i,j each being a nonlinear function of the power of the illumination p i,j of the respective pixel ; - at least one summing device configured to add up the nonlinear pixel signals s' i,j of all pixels i, j or of the at least one group of pixels and to generate at least one nonlinear sum signal S'= ∑ i,j s' i,j ; and - at least one evaluation device , the evaluation device being configured to determine at least one longitudinal coordinate z of the object by evaluating the nonlinear sum signal S'; characterized in that the detector is configured such that the nonlinear sum signal S' is a function S'(P, d) of the overall power of illumination of the optical sensor or the at least one group of pixels by the light beam P= ∑ i,j p i,j and the size d of a light spot generated by the light beam on the optical sensor . - at least one optical sensor , the optical sensor being configured to detect at least one light spot generated by at least one light beam propagating from the object towards the detector , the optical sensor having at least one matrix of pixels , each pixel being adapted to generate at least one pixel signal s i,j in response to an illumination of the pixel by the light beam ; - at least one non-linearization device configured to transform the pixel signals s i,j of all pixels i, j or of at least one group of pixels into nonlinear pixel signals s' i,j , the nonlinear pixel signals s' i,j each being a nonlinear function of the power of the illumination p i,j of the respective pixel ; - at least one summing device configured to add up the nonlinear pixel signals s' i,j of all pixels i, j or of the at least one group of pixels and to generate at least one nonlinear sum signal S'= ∑ i,j s' i,j ; and - at least one evaluation device , the evaluation device being configured to determine at least one longitudinal coordinate z of the object by evaluating the nonlinear sum signal S'; characterized in that the detector is configured such that the nonlinear sum signal S' is a function S'(P, d) of the overall power of illumination of the optical sensor or the at least one group of pixels by the light beam P= ∑ i,j p i,j and the size d of a light spot generated by the light beam on the optical sensor .
A female quick coupling comprising: a housing defining an axial bore having a first shoulder and a first slot transverse to the axial bore; a locking member slidingly received in the first slot for locking a male fluid line in the axial bore of the housing , a removable insert seated against the first shoulder within the axial bore , characterized in that the removable insert has mating frustum-shaped bores that define a restriction orifice , whereir the mating frustum-shaped bores comprise an upstream conical frustum and a downstream conical frustum mated at their respective smaller diameter. a housing defining an axial bore having a first shoulder and a first slot transverse to the axial bore; a locking member slidingly received in the first slot for locking a male fluid line in the axial bore of the housing , a removable insert seated against the first shoulder within the axial bore , characterized in that the removable insert has mating frustum-shaped bores that define a restriction orifice , whereir the mating frustum-shaped bores comprise an upstream conical frustum and a downstream conical frustum mated at their respective smaller diameter.
Method for producing a backlightable decorative component , particularly a panel component , comprising the following steps: - providing a metal decorative layer made of a fine sheet, particularly a thin sheet, - joining the metal decorative layer with a carrier layer made of a plastic material, wherein the carrier layer is at least partially transparent or translucent, and wherein the carrier layer , in the joined state, forms a rear layer behind the metal decorative layer , and - at least partially embossing the carrier layer in an at least partially softened state of the plastic material to fill a plurality of recesses in the metal decorative layer with the plastic material, starting from the rear carrier layer , characterized in that the recesses filled with the plastic material form raster elements , particularly pixels, which in combination form at least one backlightable rasterized design element of the decorative component , and the recesses filled with the plastic material are flush filled with the plastic material. - providing a metal decorative layer made of a fine sheet, particularly a thin sheet, - joining the metal decorative layer with a carrier layer made of a plastic material, wherein the carrier layer is at least partially transparent or translucent, and wherein the carrier layer , in the joined state, forms a rear layer behind the metal decorative layer , and wherein the carrier layer is at least partially transparent or translucent, and wherein the carrier layer , in the joined state, forms a rear layer behind the metal decorative layer , and - at least partially embossing the carrier layer in an at least partially softened state of the plastic material to fill a plurality of recesses in the metal decorative layer with the plastic material, starting from the rear carrier layer , the recesses filled with the plastic material form raster elements , particularly pixels, which in combination form at least one backlightable rasterized design element of the decorative component , and the recesses filled with the plastic material are flush filled with the plastic material.
A wheelchair accessible vehicle comprising a wheelchair securement system for securing a wheelchair in a wheelchair securement area , characterized in that the wheelchair accessible vehicle further comprises: a sensor configured to detect at least one of a location, a direction, and a speed of the wheelchair during at least one of a loading operation and an unloading operation of the wheelchair into the wheelchair securement area ; and a controller configured to communicate with the wheelchair securement system and configured to receive a signal from the sensor , wherein the signal is indicative of at least one of the location, the direction and the speed of the wheelchair . a sensor configured to detect at least one of a location, a direction, and a speed of the wheelchair during at least one of a loading operation and an unloading operation of the wheelchair into the wheelchair securement area ; and a controller configured to communicate with the wheelchair securement system and configured to receive a signal from the sensor , wherein the signal is indicative of at least one of the location, the direction and the speed of the wheelchair .
A method for manufacturing a perforated, sheet-like high-voltage insulating spacer for a high-voltage component, said high-voltage component comprising a field grading condenser core with the spacer which is wound in spiral form around an axis (A), with electrically conducting layers which are inserted between successive windings of the spacer , and with a polymeric matrix which penetrates the spacer and which embeds the spacer and the layers, characterized in that an electrically insulating tape is moved in a running direction (R), that a pattern (P) of parallel extended cutting lines is inserted into the tape , and that the patterned tape is expanded at right angle to the cutting lines in order to form a spacer with a perforated three-dimensional lattice structure (LS).
An infusion pump comprising: a housing including a tube port configured to receive an intravenous ("IV") tube , wherein the tube port includes a tube channel having an inlet end and an outlet end , the infusion pump being characterized in that the tube port further includes a rib positioned along the tube channel adjacent the outlet end, wherein the rib is formed to extend outwardly from a surface of the tube channel, to split the tube channel into two channels. a tube channel having an inlet end and an outlet end , the infusion pump being characterized in that the tube port further includes a rib positioned along the tube channel adjacent the outlet end, wherein the rib is formed to extend outwardly from a surface of the tube channel, to split the tube channel into two channels.