An indole amide compound of the following Formula or , or a pharmaceutically acceptable salt or R or S isomer or diastereomer thereof: in which R1 represents hydrogen, C 1 -C 6 -alkyl or -(CH 2 ) n -C 3 -C 8 -cycloalkyl, preferably wherein R1 is hydrogen, isopentyl or cyclopentylmethyl; R2 represents cyclopentyl, piperidine, isopentyl, cyclopentylmethyl, phenethyl, pentyl, cyclopropylmethyl, 2-aminopyridin-3-ylmethyl, thiazolmethyl, pyrrolidine, pyrrolidin-2-ylmethyl, piperidin-3-yl, aminomethylcarbonyl, acetic acid, tetrahydropyran or cyclohexyl; R3 represents halogen or C 1 -C 3 -alkyl; R5 represents -(CH 2 ) m -R10, wherein R10 represents hydrogen, C 1 -C 6 -alkyl or C 6 -C 10 -aryl; B represents phenyl, pyrrolidine, morpholine, thiazole or indazole; Z and Z' independently of one another represent a direct bond, -(CH 2 ) m -, -O- or -N-; R8 and R9 independently of one another represent hydrogen, hydroxy, amino, C 1 -C 6 -alkyl, -CO 2 R7, C 6 -C 10 -aryl, C 6 -C 10 -aryloxy, C 6 -C 10 -aryl-C 1 -C 6 -alkyl or C 6 -C 10 -aryl-C 1 -C 6 -alkylamino, or represent 4- to 8-membered heterocyclyl which has 1 to 3 heteroatoms selected from N and O, provided that when Z' is -O-, R9 does not exist in Formula ; R7 represents hydrogen or represents 5- or 6-membered heterocyclyl or heteroaryl, each of which optionally contains oxo and has 1 to 3 heteroatoms selected from N, O and S; m denotes a number of 0 to 3; n denotes a number of 0 to 2; and where alkyl and aryl may be optionally substituted, and the substituents are one or more selected from the group consisting of halogen, amino, dialkylamino, alkyl, and oxo; or the compound (3-aminomethyl-pyrrolidin-1-yl)-(5-chloro-7-piperidin-1-yl-1H-indol-2-yl]-methanone or [7-cyclopentylamino-5-(1,1-dioxo-thiomorpholin-4-yl-methyl)-1H-indol-2-yl]-pyrrolidin-1-yl-methanone. R1 represents hydrogen, C 1 -C 6 -alkyl or -(CH 2 ) n -C 3 -C 8 -cycloalkyl, preferably wherein R1 is hydrogen, isopentyl or cyclopentylmethyl; R2 represents cyclopentyl, piperidine, isopentyl, cyclopentylmethyl, phenethyl, pentyl, cyclopropylmethyl, 2-aminopyridin-3-ylmethyl, thiazolmethyl, pyrrolidine, pyrrolidin-2-ylmethyl, piperidin-3-yl, aminomethylcarbonyl, acetic acid, tetrahydropyran or cyclohexyl; R3 represents halogen or C 1 -C 3 -alkyl; R5 represents -(CH 2 ) m -R10, wherein R10 represents hydrogen, C 1 -C 6 -alkyl or C 6 -C 10 -aryl; B represents phenyl, pyrrolidine, morpholine, thiazole or indazole; Z and Z' independently of one another represent a direct bond, -(CH 2 ) m -, -O- or -N-; R8 and R9 independently of one another represent hydrogen, hydroxy, amino, C 1 -C 6 -alkyl, -CO 2 R7, C 6 -C 10 -aryl, C 6 -C 10 -aryloxy, C 6 -C 10 -aryl-C 1 -C 6 -alkyl or C 6 -C 10 -aryl-C 1 -C 6 -alkylamino, or represent 4- to 8-membered heterocyclyl which has 1 to 3 heteroatoms selected from N and O, provided that when Z' is -O-, R9 does not exist in Formula ; R7 represents hydrogen or represents 5- or 6-membered heterocyclyl or heteroaryl, each of which optionally contains oxo and has 1 to 3 heteroatoms selected from N, O and S; m denotes a number of 0 to 3; n denotes a number of 0 to 2; and where alkyl and aryl may be optionally substituted, and the substituents are one or more selected from the group consisting of halogen, amino, dialkylamino, alkyl, and oxo; or <EOS>