mhurhangee/patent-ind-claim-en huggingface dataset:
Individualized cancer vaccine, obtainable by a method comprising (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing an individualized cancer vaccine featuring the cancer mutation signature obtained in step (a), wherein the individualized cancer vaccine is an RNA vaccine comprising RNA encoding a recombinant polyepitopic polypeptide comprising 5 or more neo-epitopes, for use in a method of preventing or treating cancer in a patient, said method comprising the steps of: (i) inducing a first immune response against one or more shared tumor antigens in the patient by administering a vaccine comprising (ia) one or more peptides or polypeptides each peptide or polypeptide comprising one or more shared tumor antigens expressed in cancer cells of the patient, (ib) one or more peptides or polypeptides each peptide or polypeptide comprising one or more T cell epitopes of one or more shared tumor antigens expressed in cancer cells of the patient or (ic) nucleic acid encoding the one or more peptides or polypeptides of (ia) or (ib), wherein the shared tumor antigens are tumor antigens shared by at least 60% of different patients having the same cancer type and/or different cancer types, and (ii) inducing a second immune response against one or more tumor antigens in the patient, wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient, and wherein the second immune response is induced by administering the individualized cancer vaccine. (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing an individualized cancer vaccine featuring the cancer mutation signature obtained in step (a), wherein the individualized cancer vaccine is an RNA vaccine comprising RNA encoding a recombinant polyepitopic polypeptide comprising 5 or more neo-epitopes, (i) inducing a first immune response against one or more shared tumor antigens in the patient by administering a vaccine comprising (ia) one or more peptides or polypeptides each peptide or polypeptide comprising one or more shared tumor antigens expressed in cancer cells of the patient, (ib) one or more peptides or polypeptides each peptide or polypeptide comprising one or more T cell epitopes of one or more shared tumor antigens expressed in cancer cells of the patient or (ic) nucleic acid encoding the one or more peptides or polypeptides of (ia) or (ib), wherein the shared tumor antigens are tumor antigens shared by at least 60% of different patients having the same cancer type and/or different cancer types, and (ii) inducing a second immune response against one or more tumor antigens in the patient, wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient, and wherein the second immune response is induced by administering the individualized cancer vaccine.
Method for producing an application member for applying a cosmetic product, the application member comprising: - an application portion ; - a longitudinal core , housed in the application portion ; the method comprising the following successive steps: - a first step of injecting the application portion into a cavity of a mold ; - a second step of injecting the longitudinal core into the cavity of the mold , characterized in that - in the first step, a pin is arranged inside the cavity , - in the second step, the pin is moved relative to the cavity and the longitudinal core is injected into a space freed up by the pin , the injection of the longitudinal core and the movement of the pin being synchronized so that the space freed up by the pin is constantly completely filled with an injected material. - an application portion ; - a longitudinal core , housed in the application portion ; - a first step of injecting the application portion into a cavity of a mold ; - a second step of injecting the longitudinal core into the cavity of the mold , - in the first step, a pin is arranged inside the cavity , - in the second step, the pin is moved relative to the cavity and the longitudinal core is injected into a space freed up by the pin ,
An injectable pharmaceutical composition for use in a method of delivering at least one antibiotic to one or more infected spinal sites of a subject in need, comprising: (a) an effective amount of an antibiotic; (b) a thermosensitive hydrogel; (c) a radio-contrast agent; and (d) at least one pharmaceutically acceptable excipient, wherein the thermosensitive hydrogel is composed of biodegradable and biocompatible polymers, wherein the polymer is poloxamer, and wherein the poloxamer is poloxamer 407 wherein said poloxamer 407 is present from about 2% to about 20 % by weight or by volume of the composition; wherein the radio-contrast agent is Iohexol; and wherein the composition is an aqueous solution at temperature from about 4°C to about 25°C, and wherein the aqueous solution is a gel at a temperature from about 32°C to about 38 °C. (a) an effective amount of an antibiotic; (b) a thermosensitive hydrogel; (c) a radio-contrast agent; and (d) at least one pharmaceutically acceptable excipient, wherein the thermosensitive hydrogel is composed of biodegradable and biocompatible polymers, wherein the polymer is poloxamer, and wherein the poloxamer is poloxamer 407 wherein said poloxamer 407 is present from about 2% to about 20 % by weight or by volume of the composition; wherein the radio-contrast agent is Iohexol; and wherein the composition is an aqueous solution at temperature from about 4°C to about 25°C, and wherein the aqueous solution is a gel at a temperature from about 32°C to about 38 °C. wherein the thermosensitive hydrogel is composed of biodegradable and biocompatible polymers, wherein the polymer is poloxamer, and wherein the poloxamer is poloxamer 407 wherein said poloxamer 407 is present from about 2% to about 20 % by weight or by volume of the composition; wherein the radio-contrast agent is Iohexol; and wherein the composition is an aqueous solution at temperature from about 4°C to about 25°C, and wherein the aqueous solution is a gel at a temperature from about 32°C to about 38 °C.
An electronic safety actuator for an elevator safety brake, comprising: a first solenoid ; a magnet , movable by the first solenoid between a first position proximate to the first solenoid and a second position distal from the first solenoid ; a second solenoid ; and a detector arranged to apply an electrical signal to one of the first solenoid and the second solenoid , and to detect an electrical signal induced in the other of the first solenoid and the second solenoid as a result of the applied electrical signal. a first solenoid ; a magnet , movable by the first solenoid between a first position proximate to the first solenoid and a second position distal from the first solenoid ; a second solenoid ; and a detector arranged to apply an electrical signal to one of the first solenoid and the second solenoid , and to detect an electrical signal induced in the other of the first solenoid and the second solenoid as a result of the applied electrical signal.
A computer-implemented method, comprising: obtaining a representation of a source process having process functionality; translating the representation of the source process to a translated representation , wherein the translated representation includes details about tables, fields which require values, and a definition of a template hierarchy; identifying a configuration tool instance that is to be used; generating configuration templates , with the identified configuration tool instance, from the translated representation, with user configuration input mechanisms that receive user configuration inputs to configure a system instance with the process functionality, wherein the identified configuration tool instance uses metadata from the translated representation to automatically generate the configuration templates, including templates, subtemplates, question groups, and questions through which the user provides the user configuration inputs; receiving the user configuration inputs to obtain a configured configuration template; and applying the configured configuration template to the system instance to obtain a configured instance of the system that has the process functionality of the source process . obtaining a representation of a source process having process functionality; translating the representation of the source process to a translated representation , wherein the translated representation includes details about tables, fields which require values, and a definition of a template hierarchy; identifying a configuration tool instance that is to be used; generating configuration templates , with the identified configuration tool instance, from the translated representation, with user configuration input mechanisms that receive user configuration inputs to configure a system instance with the process functionality, wherein the identified configuration tool instance uses metadata from the translated representation to automatically generate the configuration templates, including templates, subtemplates, question groups, and questions through which the user provides the user configuration inputs; receiving the user configuration inputs to obtain a configured configuration template; and applying the configured configuration template to the system instance to obtain a configured instance of the system that has the process functionality of the source process .
A computer-implemented method of curves and surfaces styling design of an industrial product wherein oriented and non-oriented constraints between geometries of the industrial product are modeled with a graph of constraints comprising nodes and edges, a node representing a geometry and an edge representing a constraint between two geometries, an oriented-constraint being represented by an oriented edge, the method comprising the steps of: - selecting, upon user action, at least one geometry of the product; - computing, for each node of the graph, a depth value from a node that represents the at least one geometry previously selected, wherein the depth value of said each node corresponds to the number of edges that are met when traversing the graph from the node that represents the at least one geometry previously selected to said each node; - identifying one or more antagonistic constraint(s) in the graph, an antagonistic constraint being represented by an oriented edge wherein the depth value of the start node is larger to the depth value of the end node; - reversing the identified one or more antagonistic constraint(s); - modifying, upon user action, the at least one selected geometry; - propagating the modification of the selected geometry by solving the geometries according to the constraints modeled in the graph of constraints in accordance with the modification of the at least one selected geometry, the solving being performed according to a sequence order that is defined by the computed depth values. - selecting, upon user action, at least one geometry of the product; - computing, for each node of the graph, a depth value from a node that represents the at least one geometry previously selected, wherein the depth value of said each node corresponds to the number of edges that are met when traversing the graph from the node that represents the at least one geometry previously selected to said each node; - identifying one or more antagonistic constraint(s) in the graph, an antagonistic constraint being represented by an oriented edge wherein the depth value of the start node is larger to the depth value of the end node; - reversing the identified one or more antagonistic constraint(s); - modifying, upon user action, the at least one selected geometry; - propagating the modification of the selected geometry by solving the geometries according to the constraints modeled in the graph of constraints in accordance with the modification of the at least one selected geometry, the solving being performed according to a sequence order that is defined by the computed depth values.
A nucleic acid molecule comprising: (a) a first polynucleotide having at least 95% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1; and (b) a second polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 4; wherein (a) and (b) are joined 5'-3' in this order either contiguously or wherein 1-10 linker nucleotides are present between the first and second polynucleotides, and wherein said nucleic acid molecule is capable of promoting transcription of an operably-linked heterologous polynucleotide in a mammalian cell. (a) a first polynucleotide having at least 95% nucleotide sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1; and (b) a second polynucleotide having the nucleotide sequence set forth in SEQ ID NO: 4;
Use of N,N,N',N'-tetrakis(2-hydroxypropyl)hexane-1,6-diamine as an additive in an aqueous coating composition for improving the viscosity behavior of the aqueous coating composition, wherein the aqueous coating composition comprises water glass and at least one organic polymeric binder and has a volatile organic compound content of less than 3,000 ppm, determined according to DIN EN ISO 11890-2:2013.
A gas meter comprising: a meter body that has an internal space ; a meter inlet through which a fluid flows into the internal space of the meter body ; a meter outlet from which the fluid flows out of the meter body ; a shielding plate that is located inside the internal space of the meter body with a predetermined distance from an opening portion of the meter inlet ; a flow rate measurer that measures a flow rate of the fluid; and a connection member that connects an outlet of the flow rate measurer and the meter outlet to each other, wherein the meter inlet , the shielding plate , the flow rate measurer , the connection member , and the meter outlet are linearly located in this order, characterized in that the shielding plate is located so that the fluid flowing from the meter inlet into the internal space of the meter body is spread by the shielding plate in all directions in the internal space of the meter body . a meter body that has an internal space ; a meter inlet through which a fluid flows into the internal space of the meter body ; a meter outlet from which the fluid flows out of the meter body ; a shielding plate that is located inside the internal space of the meter body with a predetermined distance from an opening portion of the meter inlet ; a flow rate measurer that measures a flow rate of the fluid; and a connection member that connects an outlet of the flow rate measurer and the meter outlet to each other, wherein the meter inlet , the shielding plate , the flow rate measurer , the connection member , and the meter outlet are linearly located in this order, characterized in that the shielding plate is located so that the fluid flowing from the meter inlet into the internal space of the meter body is spread by the shielding plate in all directions in the internal space of the meter body .
Honeycomb core for dimensionally stable panels and reflectors in sandwich construction comprising a plurality of cells with a triangular cell cross section made from carbon fibre reinforced plastic, characterised in that the honeycomb core is assembled from flat laminate strips by insertion, wherein the laminate strips have slots running transversely to the extension direction respectively on their longitudinal side, wherein the laminate strips are connected to one another in such a way that the slots of three laminate strips engage in a positive-locking manner in one another at a respective intersection point to form the corners of the cells of the honeycomb core , wherein the honeycomb core is assembled from a number of laminate strips of a first type, being parallel to one another, which comprise first and second slots distributed at regular intervals, wherein the first slots extend, starting out from a first longitudinal side , by a third transversely to the extension direction and wherein the second slots extend, starting out from a second longitudinal side , by a third transversely to the extension direction, and wherein the first and the second slots run in a line; a number of laminate strips of a second type, being parallel to one another, which comprise slots distributed at regular intervals, wherein the slots extend, starting out from a first longitudinal side , by two thirds transversely to the extension direction; and a number of laminate strips of a third type, being parallel to one another, which comprise slots distributed at regular intervals, wherein the slots extend, starting out from a second longitudinal side , by two thirds transversely to the extension direction.
A transport system , in particular a multi-carrier system, comprising - a central control ; - a plurality of drive units (14a-14c), wherein the drive units (14a-14c) are coupled to the central control by means of a data link ; and - a plurality of transport elements (28a-28e) which are movable by means of the drive units (14a-14c), wherein the central control is configured to communicate control commands to the drive units (14a-14c), with the control commands causing the drive units (14a-14c) to make a movement of the transport elements (28a-28e) in dependence on the control commands , wherein the control commands comprise commands to move at least two transport elements (28a-28e), with the drive units (14a-14c) being configured to process the control commands in dependence on a position of the transport elements (28a-28e), characterized in that at least two of the drive units (14a-14c), preferably all the drive units (14a-14c), receive the same control commands and the at least two of the drive units (14a-14c) comprise a filter which is configured to filter the commands relevant for the respective drive unit (14a-14c) from the control commands , with the relevant commands relating to those transport elements (28a-28e) that can currently be moved by the respective drive unit (14a-14c). - a central control ; - a plurality of drive units (14a-14c), wherein the drive units (14a-14c) are coupled to the central control by means of a data link ; and - a plurality of transport elements (28a-28e) which are movable by means of the drive units (14a-14c), at least two of the drive units (14a-14c), preferably all the drive units (14a-14c), receive the same control commands and the at least two of the drive units (14a-14c) comprise a filter which is configured to filter the commands relevant for the respective drive unit (14a-14c) from the control commands , with the relevant commands relating to those transport elements (28a-28e) that can currently be moved by the respective drive unit (14a-14c).
A method of enabling a mobile machine to provide information to a device of a recipient, characterized in that the method comprises the mobile machine transmitting over a first air interface information for enabling access by the device of the recipient for controlling the mobile machine over a cellular mobile communication interface .
A door body that opens and closes a front part of an article body, comprising: a front panel constituting a front of the door body; a frame supporting at least a part of an outside edge of the front panel; and a back panel constituting a back of the door body, wherein the front panel comprises a hard coat laminated sheet, the hard coat laminated sheet comprises: a first hard coat, a second hard coat; and a transparent resin sheet layer in order from a surface layer side on a front side, the first hard coat is formed of a coating material containing no inorganic particles, the second hard coat is formed of a coating material containing inorganic particles, and the hard coat laminated sheet satisfies that: (i) total light transmittance is 80% or more, wherein the total light transmittance is measured according to JIS K7361-1:1997 by using a turbidimeter; (ii) haze is 5% or less, wherein the haze is measured according to JIS K7136:2000 by using a turbidimeter; and (iii) yellowness index is 3 or less, wherein the yellowness index is measured according to JIS K7105:1981 by using a colorimeter. a front panel constituting a front of the door body; a frame supporting at least a part of an outside edge of the front panel; and a back panel constituting a back of the door body, wherein the front panel comprises a hard coat laminated sheet, the hard coat laminated sheet comprises: a first hard coat, a second hard coat; and a transparent resin sheet layer in order from a surface layer side on a front side, the first hard coat is formed of a coating material containing no inorganic particles, the second hard coat is formed of a coating material containing inorganic particles, and the hard coat laminated sheet satisfies that: (i) total light transmittance is 80% or more, wherein the total light transmittance is measured according to JIS K7361-1:1997 by using a turbidimeter; (ii) haze is 5% or less, wherein the haze is measured according to JIS K7136:2000 by using a turbidimeter; and (iii) yellowness index is 3 or less, wherein the yellowness index is measured according to JIS K7105:1981 by using a colorimeter. (i) total light transmittance is 80% or more, wherein the total light transmittance is measured according to JIS K7361-1:1997 by using a turbidimeter; (ii) haze is 5% or less, wherein the haze is measured according to JIS K7136:2000 by using a turbidimeter; and (iii) yellowness index is 3 or less, wherein the yellowness index is measured according to JIS K7105:1981 by using a colorimeter.
A computer-implemented method comprising: detecting, via a processor , a voice trigger included in audio content received via a microphone associated with a listening device ; characterized in that , in response to detecting the voice trigger: temporally compressing at least a portion of the audio content that was recorded within several seconds or several minutes prior to detecting the voice trigger to generate temporally compressed sound, and reproducing the temporally compressed sound. temporally compressing at least a portion of the audio content that was recorded within several seconds or several minutes prior to detecting the voice trigger to generate temporally compressed sound, and reproducing the temporally compressed sound.
An aqueous coating composition comprising by dry weight based on total dry weight of the coating composition, from 2% to 16% of a small-particle-size polymeric dispersion of (co)polymeric particles having an average particle size of from 30 to 90nm wherein the particles comprise at least one ethylenically unsaturated nonionic monomer selected from methyl methacrylate, ethyl acrylate, butyl acrylate, 2-ethylhexyl acrylate, styrene, and the combinations thereof and less than 10% by dry weight based on total dry weight of the (co)polymeric particles of a stabilizer monomer, and from 25% to 70% titanium dioxide particles; wherein from 50% to 100% of the titanium dioxide particles are encapsulated by a polymer shell of (co)polymeric particles comprising at least one ethylenically unsaturated nonionic monomer selected from methyl methacrylate, ethyl acrylate, butyl acrylate, 2-ethylhexyl acrylate, styrene, and the combinations thereof and less than 10% by dry weight based on total dry weight of the (co)polymeric particles of a stabilizer monomer.