An in-vitro process for diagnosing breast cancer in a human individual comprising determining the presence or absence of all of the epigenetic chromosome interactions represented by the following probes (Marker Set 3) in a sample obtained from the individual: - 5'-TTGGAGGGAAAAGTAATTACGTTCAACTTCGACTGTATTCTACAAAGTGCTGGGATTACA-3'; - 5'-GGAGGAGGCCAGAGAAAAGAGAATGTGATCGATTTCTAAAATACTGTGTGTGTGTATGTA-3'; - 5'-GGAGGAGGCCAGAGAAAAGAGAATGTGATCGATGACCTTAATGTCAGTGTCACTGACTCT-3'; - 5'-CAGAAATGCACGCACAGGCACAACAGCATCGAAACCGGTTCTTTGGAGGCTCAGTTTTTG-3'; - 5'-CCAAAGACAGCCAAGGAAAAACTAAAGATCGAAAGTTTTTATTACTTCCAAATTAGTAAA-3'; - 5'-AGGATCTCATGATGCTTTGAATACTTTCTCGATACCTTATTATAAAATCAGCTTTGTGTT-3'; - 5'-CATAATTTTTTTTTGTAGTTTATTCACCTCGACTAGATTTTAATTTTTAATTTTTATTTA-3'; - 5'-CCTACATATACATGGAATATTCCTGGTATCGAAATATTTTAGGTAATCATTATTTGTCTA-3'; - 5'-ATTTCTTTCTTCTTCCCATTTTCTAAAATCGATTTTTAAATTAAAGGTACAAGTTAAGGC-3'; - 5'-ATACTCATCATAAATGTCAGATTTATAATCGAGATCACAGTGAGCTGAGATTGCACCACT-3'; - 5'-AGCTCAAATTCTTTTACTAATTGTTACATCGAAAGTTCAAAATTAAATTTTAAACGTTTT-3'; - 5'-GGATGGAGGAAGAGGAGGAATTCAAGACTCGAACTAAACAAAAAGGAGATGATCCTGGGT-3'; - 5'-AATTTAGAGGAACTCTATATAAACAACATCGAAACTTTGCTTCATGCACAAAATTTAAAA-3'; wherein the presence or absence of said epigenetic chromosome interactions is determined by: (i) cross-linking of chromosome regions which have come together in an epigenetic chromosome interaction; (ii) subjecting said cross-linked regions to cleavage, optionally by restriction digestion cleavage with an enzyme; (iii) ligating said cross-linked cleaved DNA ends to form ligated nucleic acids, and (iv) detecting the presence or absence of ligated nucleic acids corresponding to the epigenetic chromosome interactions represented by the above probes to thereby detect the presence or absence of said epigenetic chromosome interactions. - 5'-TTGGAGGGAAAAGTAATTACGTTCAACTTCGACTGTATTCTACAAAGTGCTGGGATTACA-3'; - 5'-GGAGGAGGCCAGAGAAAAGAGAATGTGATCGATTTCTAAAATACTGTGTGTGTGTATGTA-3'; - 5'-GGAGGAGGCCAGAGAAAAGAGAATGTGATCGATGACCTTAATGTCAGTGTCACTGACTCT-3'; - 5'-CAGAAATGCACGCACAGGCACAACAGCATCGAAACCGGTTCTTTGGAGGCTCAGTTTTTG-3'; - 5'-CCAAAGACAGCCAAGGAAAAACTAAAGATCGAAAGTTTTTATTACTTCCAAATTAGTAAA-3'; - 5'-AGGATCTCATGATGCTTTGAATACTTTCTCGATACCTTATTATAAAATCAGCTTTGTGTT-3'; - 5'-CATAATTTTTTTTTGTAGTTTATTCACCTCGACTAGATTTTAATTTTTAATTTTTATTTA-3'; - 5'-CCTACATATACATGGAATATTCCTGGTATCGAAATATTTTAGGTAATCATTATTTGTCTA-3'; - 5'-ATTTCTTTCTTCTTCCCATTTTCTAAAATCGATTTTTAAATTAAAGGTACAAGTTAAGGC-3'; - 5'-ATACTCATCATAAATGTCAGATTTATAATCGAGATCACAGTGAGCTGAGATTGCACCACT-3'; - 5'-AGCTCAAATTCTTTTACTAATTGTTACATCGAAAGTTCAAAATTAAATTTTAAACGTTTT-3'; - 5'-GGATGGAGGAAGAGGAGGAATTCAAGACTCGAACTAAACAAAAAGGAGATGATCCTGGGT-3'; - 5'-AATTTAGAGGAACTCTATATAAACAACATCGAAACTTTGCTTCATGCACAAAATTTAAAA-3'; (i) cross-linking of chromosome regions which have come together in an epigenetic chromosome interaction; (ii) subjecting said cross-linked regions to cleavage, optionally by restriction digestion cleavage with an enzyme; (iii) ligating said cross-linked cleaved DNA ends to form ligated nucleic acids, and (iv) detecting the presence or absence of ligated nucleic acids corresponding to the epigenetic chromosome interactions represented by the above probes to thereby detect the presence or absence of said epigenetic chromosome interactions. <EOS>