A compound selected from compounds of the following formula, and pharmaceutically acceptable salts, hydrates, and solvates thereof: wherein: one of X 1 , X 2 , and X 3 is independently O or S; each of the other two of X 1 , X 2 , and X 3 is N; Y 1 is independently O or S; Y 2 is independently CH, CR Y or N; -R Y is saturated linear or branched C 1-3 alkyl; -R Q1 is independently -R Q1A , -R Q1B , or -R Q1C ; -R Q1A is saturated linear or branched C 1-3 alkyl; -R Q1B is -F, -Cl, -Br, or -I; -R Q1C is -CF 3 ; -R Q2 is independently -R Q2A , -R Q2B , or -R Q2C ; -R Q2A is saturated linear or branched C 1-3 alkyl; -R Q2B is independently -F, -Cl, -Br, or -I; -R Q2C is -CF 3 ; -R Q3 is independently -H or -R Q3X ; -R Q3X is independently -R Q3A , -R Q3B , -R Q3C , or -R Q3D ; -R Q3A is saturated linear or branched C 1-3 alkyl; -R Q3B is saturated linear or branched C 1-3 alkoxy; -R Q3C is independently -F, -Cl, -Br, or -I; -R Q3D is -CF 3 ; -R Q4 is independently -H or -R Q4X ; -R Q4X is independently -R Q4A , -R Q4B , -R Q4C , or -R Q4D ; -R Q4A is saturated linear or branched C 1-3 alkyl; -R Q4B is saturated linear or branched C 1-3 alkoxy; -R Q4C is independently -F, -Cl, -Br, or -I; -R Q4D is -CF 3 ; one of -R P1 and -R P2 is -H or -R P ; the other of -R P1 and -R P2 is -H; -R P is independently -R PA , -R PB , -R PC , or -R PD ; -R PA is saturated linear or branched C 1-3 alkyl; -R PB is independently -F, -Cl, -Br, or -I; -R PC is -CF 3 ; -R PD is independently -NH 2 or -NHR PDD ; -R PDD is saturated linear or branched C 1-3 alkyl; -R A is independently -H or -R AA ; and -R AA is independently saturated linear or branched C 1-4 alkyl, phenyl, or benzyl. one of X 1 , X 2 , and X 3 is independently O or S; each of the other two of X 1 , X 2 , and X 3 is N; Y 1 is independently O or S; Y 2 is independently CH, CR Y or N; -R Y is saturated linear or branched C 1-3 alkyl; -R Q1 is independently -R Q1A , -R Q1B , or -R Q1C ; -R Q1A is saturated linear or branched C 1-3 alkyl; -R Q1B is -F, -Cl, -Br, or -I; -R Q1C is -CF 3 ; -R Q2 is independently -R Q2A , -R Q2B , or -R Q2C ; -R Q2A is saturated linear or branched C 1-3 alkyl; -R Q2B is independently -F, -Cl, -Br, or -I; -R Q2C is -CF 3 ; -R Q3 is independently -H or -R Q3X ; -R Q3X is independently -R Q3A , -R Q3B , -R Q3C , or -R Q3D ; -R Q3A is saturated linear or branched C 1-3 alkyl; -R Q3B is saturated linear or branched C 1-3 alkoxy; -R Q3C is independently -F, -Cl, -Br, or -I; -R Q3D is -CF 3 ; -R Q4 is independently -H or -R Q4X ; -R Q4X is independently -R Q4A , -R Q4B , -R Q4C , or -R Q4D ; -R Q4A is saturated linear or branched C 1-3 alkyl; -R Q4B is saturated linear or branched C 1-3 alkoxy; -R Q4C is independently -F, -Cl, -Br, or -I; -R Q4D is -CF 3 ; one of -R P1 and -R P2 is -H or -R P ; the other of -R P1 and -R P2 is -H; -R P is independently -R PA , -R PB , -R PC , or -R PD ; -R PA is saturated linear or branched C 1-3 alkyl; -R PB is independently -F, -Cl, -Br, or -I; -R PC is -CF 3 ; -R PD is independently -NH 2 or -NHR PDD ; -R PDD is saturated linear or branched C 1-3 alkyl; -R A is independently -H or -R AA ; and -R AA is independently saturated linear or branched C 1-4 alkyl, phenyl, or benzyl. <EOS>