A process for preparing a compound of Formula IIa from a compound of Formula I in a reaction mixture according to the following reaction scheme: the process comprising: (i) forming a reaction mixture comprising the compound of Formula I, organic halide, solvent system, phase transfer catalyst, and base, (ii) reacting the reaction mixture to form a reaction product mixture comprising the compound of Formula IIa, and (iii) isolating the compound of Formula IIa from the reaction product mixture, wherein the solvent system consists essentially of water; X is a halide; each R 5 , R 10 and R 15 is independently selected from H, C 1 -C 10 hydrocarbyl or from C 1 -C 5 hydrocarbyl, wherein each hydrocarbyl is optionally substituted, two geminal R 5 , R 10 and/or R 15 groups are oxo, or two geminal R 5 , R 10 and/or R 15 groups form a 3, 4, 5, 6, or 7-membered carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl is optionally substituted; mor is selected from: wherein mor is optionally substituted with one or more R 7 groups independently selected from F, Cl, Br, I, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH(CH 3 ) 2 ,-C(CH 3 ) 3 , -CH 2 OCH 3 , -CHF 2 , -CN, -CF 3 , -CH 2 OH, -CH 2 OCH 3 , -CH 2 CH 2 OH,-CH 2 C(CH 3 ) 2 OH, -CH(CH 3 )OH, -CH(CH 2 CH 3 )OH, -CH 2 CH(OH)CH 3 , -C(CH 3 ) 2 OH, -C(CH 3 ) 2 OCH 3 , -CH(CH 3 )F, -C(CH 3 )F 2 , -CH(CH 2 CH 3 )F, -C(CH 2 CH 3 ) 2 F, -CO 2 H,-CONH 2 , -CON(CH 2 CH 3 ) 2 , -COCH 3 , -CON(CH 3 ) 2 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -NHCH(CH 3 ) 2 , -NHCH 2 CH 2 OH, -NHCH 2 CH 2 OCH 3 , -NHCOCH 3 ,-NHCOCH 2 CH 3 , -NHCOCH 2 OH, -NHS(O) 2 CH 3 , -N(CH 3 )S(O) 2 CH 3 , =O, -OH,-OCH 3 , -OCH 2 CH 3 , -OCH(CH 3 ) 2 , -SH, -NHC(O)NHCH 3 , -NHC(O)NHCH 2 CH 3 ,-S(O)CH 3 , -S(O)CH 2 CH 3 , -S(O) 2 CH 3 , -S(O) 2 NH 2 , -S(O) 2 NHCH 3 , -S(O) 2 N(CH 3 ) 2 , and -CH 2 S(O) 2 CH 3 ; and wherein in Formula I R 20 is -OH or -NHR 21 wherein R 21 is as defined for R 5 , and wherein in Formula IIa R 20 is -O- or -NR 21 -. (i) forming a reaction mixture comprising the compound of Formula I, organic halide, solvent system, phase transfer catalyst, and base, (ii) reacting the reaction mixture to form a reaction product mixture comprising the compound of Formula IIa, and (iii) isolating the compound of Formula IIa from the reaction product mixture, the solvent system consists essentially of water; X is a halide; each R 5 , R 10 and R 15 is independently selected from H, C 1 -C 10 hydrocarbyl or from C 1 -C 5 hydrocarbyl, wherein each hydrocarbyl is optionally substituted, two geminal R 5 , R 10 and/or R 15 groups are oxo, or two geminal R 5 , R 10 and/or R 15 groups form a 3, 4, 5, 6, or 7-membered carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl is optionally substituted; mor is selected from: wherein mor is optionally substituted with one or more R 7 groups independently selected from F, Cl, Br, I, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 CH 3 , -CH(CH 3 ) 2 ,-C(CH 3 ) 3 , -CH 2 OCH 3 , -CHF 2 , -CN, -CF 3 , -CH 2 OH, -CH 2 OCH 3 , -CH 2 CH 2 OH,-CH 2 C(CH 3 ) 2 OH, -CH(CH 3 )OH, -CH(CH 2 CH 3 )OH, -CH 2 CH(OH)CH 3 , -C(CH 3 ) 2 OH, -C(CH 3 ) 2 OCH 3 , -CH(CH 3 )F, -C(CH 3 )F 2 , -CH(CH 2 CH 3 )F, -C(CH 2 CH 3 ) 2 F, -CO 2 H,-CONH 2 , -CON(CH 2 CH 3 ) 2 , -COCH 3 , -CON(CH 3 ) 2 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -NHCH(CH 3 ) 2 , -NHCH 2 CH 2 OH, -NHCH 2 CH 2 OCH 3 , -NHCOCH 3 ,-NHCOCH 2 CH 3 , -NHCOCH 2 OH, -NHS(O) 2 CH 3 , -N(CH 3 )S(O) 2 CH 3 , =O, -OH,-OCH 3 , -OCH 2 CH 3 , -OCH(CH 3 ) 2 , -SH, -NHC(O)NHCH 3 , -NHC(O)NHCH 2 CH 3 ,-S(O)CH 3 , -S(O)CH 2 CH 3 , -S(O) 2 CH 3 , -S(O) 2 NH 2 , -S(O) 2 NHCH 3 , -S(O) 2 N(CH 3 ) 2 , and -CH 2 S(O) 2 CH 3 ; and wherein in Formula I R 20 is -OH or -NHR 21 wherein R 21 is as defined for R 5 , and wherein in Formula IIa R 20 is -O- or -NR 21 -. <EOS>