mhurhangee/patent-ind-claim-en huggingface dataset:
A peptide of sixteen to eighteen amino acids comprising a sequence of: X 4 X 5 X 6 X 7 X 8 X 9 X 10 X 11 X 12 X 13 X 14 X 15 X 16 X 17 X 18 X 19 X 20 (SEQ ID NO: 42), wherein: X 4 is G; X 5 is L; X 6 is D, E, or H; X 7 is E or H; X 8 is N or D; X 9 is S, T, H, R, or K; X 10 is E or D; X 11 is hydroxyproline (Hyp), K, or P; X 12 is K, R, or P; X 13 is R or F; X 14 is K or dK; X 15 is Q, S, or beta-A; X 16 is A or 2-aminoisobutyric acid (B); X 17 is I; X 18 is K, I, or F; X 19 is dA, I, A, L, V, dL, or dV; and X 20 is I, L, V, dI, dL, dV, or absent; wherein the peptide comprises a hydrophobic moiety that comprises a lipid moiety selected from the group consisting of: capryloyl (C 8 ); nonanoyl (C 9 ); capryl (C 10 ); undecanoyl (C 11 ); lauroyl (C 12 ); tridecanoyl (C 13 ); myristoyl (C 14 ); pentadecanoyl (C 15 ); palmitoyl (C 16 ); phytanoyl (methyl substituted C 16 ); heptadecanoyl (C 17 ); stearoyl (C 18 ); nonadecanoyl (C 19 ); arachidoyl (C 20 ); heneicosanoyl (C 21 ); behenoyl (C 22 ); trucisanoyl (C 23 ); and lignoceroyl (C 24 ); and wherein the peptide exhibits at least 70% inhibition of PAR2 as assessed by calcium flux using 10 μM of the peptide and 8 μM SLIGRL (SEQ ID NO: 73) in cells; or wherein the peptide exhibits at least 40% inhibition of PAR2 as assessed by calcium flux using 3 μM of the peptide and 8 μM SLIGRL (SEQ ID NO: 73) in cells. X 4 is G; X 5 is L; X 6 is D, E, or H; X 7 is E or H; X 8 is N or D; X 9 is S, T, H, R, or K; X 10 is E or D; X 11 is hydroxyproline (Hyp), K, or P; X 12 is K, R, or P; X 13 is R or F; X 14 is K or dK; X 15 is Q, S, or beta-A; X 16 is A or 2-aminoisobutyric acid (B); X 17 is I; X 18 is K, I, or F; X 19 is dA, I, A, L, V, dL, or dV; and X 20 is I, L, V, dI, dL, dV, or absent; wherein the peptide comprises a hydrophobic moiety that comprises a lipid moiety selected from the group consisting of: capryloyl (C 8 ); nonanoyl (C 9 ); capryl (C 10 ); undecanoyl (C 11 ); lauroyl (C 12 ); tridecanoyl (C 13 ); myristoyl (C 14 ); pentadecanoyl (C 15 ); palmitoyl (C 16 ); phytanoyl (methyl substituted C 16 ); heptadecanoyl (C 17 ); stearoyl (C 18 ); nonadecanoyl (C 19 ); arachidoyl (C 20 ); heneicosanoyl (C 21 ); behenoyl (C 22 ); trucisanoyl (C 23 ); and lignoceroyl (C 24 ); and wherein the peptide exhibits at least 70% inhibition of PAR2 as assessed by calcium flux using 10 μM of the peptide and 8 μM SLIGRL (SEQ ID NO: 73) in cells; or wherein the peptide exhibits at least 40% inhibition of PAR2 as assessed by calcium flux using 3 μM of the peptide and 8 μM SLIGRL (SEQ ID NO: 73) in cells.
An aerosol generating article comprising: a first body of aerosol forming material ; a first tubular member surrounding the first body of aerosol forming material ; a second body of aerosol forming material surrounding the first tubular member ; a second tubular member surrounding the second body of aerosol forming material ; wherein the first tubular member is inductively heatable in the presence of a time varying electromagnetic field. a first body of aerosol forming material ; a first tubular member surrounding the first body of aerosol forming material ; a second body of aerosol forming material surrounding the first tubular member ; a second tubular member surrounding the second body of aerosol forming material ; wherein the first tubular member is inductively heatable in the presence of a time varying electromagnetic field.
A production process for 2-acrylamido-2-methylpropane sulfonic acid including at least the following successive steps: 1) mixing of acrylonitrile with at least one compound contributing SO 3 at a temperature included between -80 and 30 °C for at least one second in order to obtain a sulfonating mixture; 2) placing in contact and mixing isobutylene and the sulfonating mixture with a molar ratio of SO 3 to isobutylene included between 0.2:1 and 2:1 and a molar ratio of acrylonitrile to isobutylene included between 3:1 and 60:1 at a temperature included between -40 and 100 °C for a time included between 10 seconds and 300 minutes in order to obtain a reaction mixture; 3) solid/liquid separation of the reaction mixture and isolation of the solid particles contained in the reaction mixture in the form of a composition 1 in which the solid particles represent 50 to 99 % by weight of the composition 1; 4) mixing composition 1 at the end of step 3) with an aqueous solution A for at least 10 minutes at a temperature included between -20 and 70 °C in order to obtain a suspension 1 of 2-acrylamido-2-methylpropane sulfonic acid crystals; 5) solid/liquid separation of the suspension 1 and isolation of the crystals in the form of a composition 2 in which the crystals represent between 40 and 99 % by weight of the composition 2. 1) mixing of acrylonitrile with at least one compound contributing SO 3 at a temperature included between -80 and 30 °C for at least one second in order to obtain a sulfonating mixture; 2) placing in contact and mixing isobutylene and the sulfonating mixture with a molar ratio of SO 3 to isobutylene included between 0.2:1 and 2:1 and a molar ratio of acrylonitrile to isobutylene included between 3:1 and 60:1 at a temperature included between -40 and 100 °C for a time included between 10 seconds and 300 minutes in order to obtain a reaction mixture; 3) solid/liquid separation of the reaction mixture and isolation of the solid particles contained in the reaction mixture in the form of a composition 1 in which the solid particles represent 50 to 99 % by weight of the composition 1; 4) mixing composition 1 at the end of step 3) with an aqueous solution A for at least 10 minutes at a temperature included between -20 and 70 °C in order to obtain a suspension 1 of 2-acrylamido-2-methylpropane sulfonic acid crystals; 5) solid/liquid separation of the suspension 1 and isolation of the crystals in the form of a composition 2 in which the crystals represent between 40 and 99 % by weight of the composition 2.
A process for joining parts together comprising: (i) positioning and temporarily clamping parts to be joined together, wherein step (i) includes clamping the parts together with Cleco fasteners; (ii) drilling a number (n) of pilot holes through the temporarily clamped parts, wherein the number (n) of pilot holes is less than a total number (N) of holes required to be drilled to allow the parts to be joined together by permanent fasteners, wherein step (ii) further comprises: (iia) removing the temporarily clamped parts from one another after the number (n) of pilot holes is drilled therein; and (iib) cleaning the parts of burrs and/or metal filings present due to said drilling; (iii) installing temporary fasteners in the number (n) of pilot holes; (iv) drilling a remaining number (η) of holes that are required in addition to the number (n) of pilot holes to achieve the total number (N) of holes required for the parts to be joined together by permanent fasteners; and (v) installing permanent fasteners in the number (n) of pilot holes and the remaining number (η) of holes drilled in step (iv) to thereby permanently join the parts together, wherein step (v) includes removing the temporary fasteners installed in the number (n) of pilot holes by drilling and thereafter installing permanent fasteners therein; wherein steps (iv) and (v) are practiced using an automated robotic drilling and assembly system and step (ii) is practiced manually. (i) positioning and temporarily clamping parts to be joined together, wherein step (i) includes clamping the parts together with Cleco fasteners; (ii) drilling a number (n) of pilot holes through the temporarily clamped parts, wherein the number (n) of pilot holes is less than a total number (N) of holes required to be drilled to allow the parts to be joined together by permanent fasteners, wherein step (ii) further comprises: (iia) removing the temporarily clamped parts from one another after the number (n) of pilot holes is drilled therein; and (iib) cleaning the parts of burrs and/or metal filings present due to said drilling; (iia) removing the temporarily clamped parts from one another after the number (n) of pilot holes is drilled therein; and (iib) cleaning the parts of burrs and/or metal filings present due to said drilling; (iii) installing temporary fasteners in the number (n) of pilot holes; (iv) drilling a remaining number (η) of holes that are required in addition to the number (n) of pilot holes to achieve the total number (N) of holes required for the parts to be joined together by permanent fasteners; and (v) installing permanent fasteners in the number (n) of pilot holes and the remaining number (η) of holes drilled in step (iv) to thereby permanently join the parts together, wherein step (v) includes removing the temporary fasteners installed in the number (n) of pilot holes by drilling and thereafter installing permanent fasteners therein;
A core/sheath composite filament for toothbrushes comprising: a core made of a synthetic resin fiber; and a sheath integrally covering the core , the core/sheath composite filament being characterized in that the sheath is made of an elastomer compatible with the synthetic resin constituting the core , the core/sheath composite filament has a cross section that is perpendicular to the lengthwise direction of the core/sheath composite filament , the cross section being formed into a quadrangular shape, and the cross section has sides each of which has the length set in the range of 0.14 to 0.30 mm. a core made of a synthetic resin fiber; and a sheath integrally covering the core , the core/sheath composite filament being characterized in that the sheath is made of an elastomer compatible with the synthetic resin constituting the core , the core/sheath composite filament has a cross section that is perpendicular to the lengthwise direction of the core/sheath composite filament , the cross section being formed into a quadrangular shape, and the cross section has sides each of which has the length set in the range of 0.14 to 0.30 mm.
An actuator for an aircraft, comprising: a cylinder , the cylinder extending along an actuator axis between a cylinder first end and a cylinder second end , and the cylinder defining a cylinder inner diameter surface ; a screw shaft that extends along the actuator axis between a screw shaft first end and a screw shaft second end , wherein the screw shaft is at least partially within the cylinder, and wherein the screw shaft is operationally connected, intermediate of the screw shaft first and second ends, to the cylinder second end; a screw shaft head affixed to the screw shaft first end, so that in operation the screw shaft head rotates relative to the cylinder, wherein the screw shaft head defines a screw shaft head outer diameter surface that faces the cylinder inner diameter surface with a slip fit therebetween; and characterized in that : the cylinder is formed of carbon fiber reinforced polymer, CFRP; and further characterized by : a bearing ring affixed to the screw shaft head outer diameter surface, wherein the bearing ring is formed of polyether ether ketone, PEEK. a cylinder , the cylinder extending along an actuator axis between a cylinder first end and a cylinder second end , and the cylinder defining a cylinder inner diameter surface ; a screw shaft that extends along the actuator axis between a screw shaft first end and a screw shaft second end , wherein the screw shaft is at least partially within the cylinder, and wherein the screw shaft is operationally connected, intermediate of the screw shaft first and second ends, to the cylinder second end; a screw shaft head affixed to the screw shaft first end, so that in operation the screw shaft head rotates relative to the cylinder, wherein the screw shaft head defines a screw shaft head outer diameter surface that faces the cylinder inner diameter surface with a slip fit therebetween; and characterized in that : the cylinder is formed of carbon fiber reinforced polymer, CFRP; and further characterized by : a bearing ring affixed to the screw shaft head outer diameter surface, wherein the bearing ring is formed of polyether ether ketone, PEEK.
A computer program comprising instructions which, when the program is executed by a computer, cause the computer to carry out a method comprising: receiving multi-planar fluoroscopic images of a patient anatomy acquired while a portion of a medical instrument is positioned within the patient anatomy, the fluoroscopic images having a fluoroscopic frame of reference, wherein the portion has a sensed position in an anatomic model frame of reference; identifying the portion in the fluoroscopic images; identifying an extracted position, relative to three degrees of translation freedom, of the portion in the fluoroscopic frame of reference using the identified portion in the fluoroscopic images; identifying an extracted orientation, relative to three rotational degrees of freedom, of the portion in the fluoroscopic frame of reference using the identified portion in the fluoroscopic images, wherein the portion has a sensed orientation in the anatomic model frame of reference; and registering the fluoroscopic frame of reference to the anatomic model frame of reference based on the sensed position of the portion, the extracted position of the portion, the sensed orientation of the portion, and the extracted orientation of the portion, wherein identifying the portion in the fluoroscopic images includes comparing the fluoroscopic images of the patient anatomy while the portion of the medical instrument is positioned at a first location within the patient anatomy to fluoroscopic images of the patient anatomy recorded when the portion of the medical instrument is positioned at a second location within the patient anatomy. receiving multi-planar fluoroscopic images of a patient anatomy acquired while a portion of a medical instrument is positioned within the patient anatomy, the fluoroscopic images having a fluoroscopic frame of reference, wherein the portion has a sensed position in an anatomic model frame of reference; identifying the portion in the fluoroscopic images; identifying an extracted position, relative to three degrees of translation freedom, of the portion in the fluoroscopic frame of reference using the identified portion in the fluoroscopic images; identifying an extracted orientation, relative to three rotational degrees of freedom, of the portion in the fluoroscopic frame of reference using the identified portion in the fluoroscopic images, wherein the portion has a sensed orientation in the anatomic model frame of reference; and registering the fluoroscopic frame of reference to the anatomic model frame of reference based on the sensed position of the portion, the extracted position of the portion, the sensed orientation of the portion, and the extracted orientation of the portion, wherein identifying the portion in the fluoroscopic images includes comparing the fluoroscopic images of the patient anatomy while the portion of the medical instrument is positioned at a first location within the patient anatomy to fluoroscopic images of the patient anatomy recorded when the portion of the medical instrument is positioned at a second location within the patient anatomy.
A method for measuring surface characteristics of at least a portion of an object , being at least partially submerged in an optically distorting liquid medium comprising: providing at least one light source ; directing light from the at least one light source to generate a first interference pattern on the at least a portion of the object ; capturing at least one first image of the first interference pattern; shifting the phase of the at least one light source to generate a second interference pattern; capturing at least one second image of the second interference pattern; filtering distortion from the first interference pattern and/or the second interference pattern by eliminating changes in the index of refraction caused by thermal differences and flow of liquid; extracting a wrapped phase of the at least a portion of the object based on the at least one first image and the at least one second image ; unwrapping the wrapped phase of the at least a portion of the object to generate an unwrapped phase; identifying a computed depth map distance to the at least a portion of the object based on the unwrapped phase; and fitting an ideal part to the computed depth map of the at least a portion of the object to measure the surface characteristics. providing at least one light source ; directing light from the at least one light source to generate a first interference pattern on the at least a portion of the object ; capturing at least one first image of the first interference pattern; shifting the phase of the at least one light source to generate a second interference pattern; capturing at least one second image of the second interference pattern; filtering distortion from the first interference pattern and/or the second interference pattern by eliminating changes in the index of refraction caused by thermal differences and flow of liquid; extracting a wrapped phase of the at least a portion of the object based on the at least one first image and the at least one second image ; unwrapping the wrapped phase of the at least a portion of the object to generate an unwrapped phase; identifying a computed depth map distance to the at least a portion of the object based on the unwrapped phase; and fitting an ideal part to the computed depth map of the at least a portion of the object to measure the surface characteristics.
A data compression device for compressing an uncompressed data set into a compressed data set , the uncompressed data set comprising a plurality of data values (2212a-m), the data compression device comprising: a separator configured to divide each data value in the data set into a plurality of semantically meaningful data fields (2214a-n); a compressor comprising one or more compression units , wherein a first compression unit among said compression units is configured to apply, for at least one of the semantically meaningful data fields of each data value, a first data compression scheme to that data field in isolation from other ones of the semantically meaningful data fields of the data value to generate a compressed data field ; and an aggregator configured to include the compressed data field in a resulting aggregated compressed data set to generate the compressed data set , characterized in that the separator (2220; 2020) is configured to further divide at least one of the semantically meaningful data fields (2214a-n) into two or more sub-fields (mH, mL); at least one of the compressor units (2230a-b; 2030a-c) is configured to apply, for at least one (mL) of the sub-fields, a data compression scheme to that sub-field in isolation from other ones (mH) of the sub-fields to generate a compressed sub-field; and the aggregator (2240; 2040) is configured to include the compressed sub-field in the resulting aggregated compressed data set to generate the compressed data set (2290; 2090). a separator configured to divide each data value in the data set into a plurality of semantically meaningful data fields (2214a-n); a compressor comprising one or more compression units , wherein a first compression unit among said compression units is configured to apply, for at least one of the semantically meaningful data fields of each data value, a first data compression scheme to that data field in isolation from other ones of the semantically meaningful data fields of the data value to generate a compressed data field ; and an aggregator configured to include the compressed data field in a resulting aggregated compressed data set to generate the compressed data set , characterized in that the separator (2220; 2020) is configured to further divide at least one of the semantically meaningful data fields (2214a-n) into two or more sub-fields (mH, mL); at least one of the compressor units (2230a-b; 2030a-c) is configured to apply, for at least one (mL) of the sub-fields, a data compression scheme to that sub-field in isolation from other ones (mH) of the sub-fields to generate a compressed sub-field; and the aggregator (2240; 2040) is configured to include the compressed sub-field in the resulting aggregated compressed data set to generate the compressed data set (2290; 2090).
An implantable prosthetic device for the repair of connective tissue in an animal or human, the device comprising a biocompatible pad having an open structure to provide a scaffold for the in-growth of tissue into the pad, a region of the pad being reinforced relative to a main part of the pad, the device further comprising a reinforcement region extending around a perimeter of the pad; characterised in that the reinforcement region is attached to the pad and positioned inboard of edges of the pad, and in that the reinforcement region comprises an elongate reinforcement element and at least one anchoring element for anchoring the reinforcement element to the pad, in which the at least one anchoring element passes through the pad in a first direction, around the reinforcement element and back through the pad in a second direction which is opposite to said first direction, to anchor the reinforcement element to the pad; in which the device can be attached to tissue by forming a puncture: a) within the reinforcement region; or b) in an area of the pad which is inboard of the reinforcement region; so that a suture can be located through the puncture, the reinforcement region serving to support tensile loading in the device during use by resisting pull-through of the suture. a) within the reinforcement region; or b) in an area of the pad which is inboard of the reinforcement region;
A method of transmitting messages, the method comprising: transmitting, by a sender (no), a data message to a receiver on a data channel; receiving, by the sender , a first group of one or more continuous repetitions (221 - 228) of a time domain waveform of an acknowledgement signal from the receiver on a control channel, wherein the acknowledgement signal comprises a plurality of continuous repetitions (221 - 228) of the time domain waveform , the plurality of continuous repetitions (221 - 228) including the first group of one or more continuous repetitions (221 - 228) and a second group of one or more continuous repetitions (221 - 228) of the time domain waveform; and decoding, by the sender the acknowledgement signal prior to fully receiving a last repetition (221 - 228) of the second group of one or more continuous repetitions (221 - 228) of the time domain waveform of the acknowledgement signal on the control channel, wherein each repetition (221 -228) in the first and second groups of one or more repetitions (221-228) are repetitions (221-228) of a same time domain waveform received during one symbol period. transmitting, by a sender (no), a data message to a receiver on a data channel; receiving, by the sender , a first group of one or more continuous repetitions (221 - 228) of a time domain waveform of an acknowledgement signal from the receiver on a control channel, wherein the acknowledgement signal comprises a plurality of continuous repetitions (221 - 228) of the time domain waveform , the plurality of continuous repetitions (221 - 228) including the first group of one or more continuous repetitions (221 - 228) and a second group of one or more continuous repetitions (221 - 228) of the time domain waveform; and decoding, by the sender the acknowledgement signal prior to fully receiving a last repetition (221 - 228) of the second group of one or more continuous repetitions (221 - 228) of the time domain waveform of the acknowledgement signal on the control channel, wherein each repetition (221 -228) in the first and second groups of one or more repetitions (221-228) are repetitions (221-228) of a same time domain waveform received during one symbol period.