mhurhangee/patent-ind-claim-en huggingface dataset:
A process for preparing ruxolitinib, a compound of Formula I, comprising the following steps: Step 3: reacting a compound of Formula II with a compound of Formula IV or a salt thereof to obtain the compound of Formula III, wherein, R is selected from H and an amino-protecting group; Step 4: converting a compound of Formula III into a compound of Formula XI, and then converting the compound of Formula XI into a compound of Formula XII in the presence of an aminating agent, wherein, R is selected from H and an amino-protecting group, and X is selected from Cl and Br; and Step 5-1: where R is H, converting the acylamino group in Formula XII into a cyano group in the presence of a dehydrating agent to obtain ruxolitinib, the compound of Formula I; or Step 5-2: where R is an amino-protecting group, converting the acylamino group in Formula XII into a cyano group and removing the amino-protecting group R to obtain ruxolitinib, the compound of Formula I; wherein, R is selected from H and an amino-protecting group. Step 3: reacting a compound of Formula II with a compound of Formula IV or a salt thereof to obtain the compound of Formula III, wherein, R is selected from H and an amino-protecting group; Step 4: converting a compound of Formula III into a compound of Formula XI, and then converting the compound of Formula XI into a compound of Formula XII in the presence of an aminating agent, wherein, R is selected from H and an amino-protecting group, and X is selected from Cl and Br; and Step 5-1: where R is H, converting the acylamino group in Formula XII into a cyano group in the presence of a dehydrating agent to obtain ruxolitinib, the compound of Formula I; or Step 5-2: where R is an amino-protecting group, converting the acylamino group in Formula XII into a cyano group and removing the amino-protecting group R to obtain ruxolitinib, the compound of Formula I; wherein, R is selected from H and an amino-protecting group.
A method for receiving acknowledgement/negative-acknowledgement, ACK/NACK, information in a wireless communication system, the method comprising: transmitting data through at least one downlink subframe; and receiving ACK/NACK information for the data, wherein the ACK/NACK information is received through a physical uplink control channel, PUCCH, resource, wherein the PUCCH resource is determined based on a sum of a number of control channel elements, CCEs, in each of control channels in the at least one downlink subframe, wherein based on a special subframe with a predefined special subframe configuration being included in the at least one downlink subframe, CCEs included in the special subframe are excluded from the sum which is used to determine the PUCCH resource, wherein the predefined special subframe configuration is the special subframe configuration 0 or 5 with normal cyclic prefix expressed by the following table: Special subframe configuration Normal cyclic prefix in downlink Extended cyclic prefix in downlink DwPTS UpPTS DwPTS UpPTS Normal cyclic prefix in uplink Extended cyclic prefix in uplink Normal cyclic prefix in uplink Extended cyclic prefix in uplink 0 6592· T s 2192· T s 2560· T s 7680· T s 2192· T s 2560· T s 1 19760· T s 20480· T s 2 21952· T s 23040· T s 3 24144· T s 25600· T s 4 26336· T s 7680· T s 4384· T s 5120· T s 5 6592· T s 4384· T s 5120· T s 20480· T s 6 19760· T s 23040· T s 7 21952· T s 12800· T s 8 24144· T s - - - 9 13168 · T s - - - wherein 307200·T s = 10 milliseconds. transmitting data through at least one downlink subframe; and receiving ACK/NACK information for the data, wherein the ACK/NACK information is received through a physical uplink control channel, PUCCH, resource, wherein the PUCCH resource is determined based on a sum of a number of control channel elements, CCEs, in each of control channels in the at least one downlink subframe, wherein based on a special subframe with a predefined special subframe configuration being included in the at least one downlink subframe, CCEs included in the special subframe are excluded from the sum which is used to determine the PUCCH resource, wherein the predefined special subframe configuration is the special subframe configuration 0 or 5 with normal cyclic prefix expressed by the following table:
A method of fabricating an edge termination structure for a silicon carbide semiconductor device , comprising: forming a plurality of spaced apart concentric floating guard rings in a silicon carbide layer that surround at least a portion of a silicon carbide-based semiconductor junction; forming an insulating oxide layer on the floating guard rings ; and forming a silicon carbide surface charge compensation region having a first part between the semiconductor junction and a floating guard ring closest to the semiconductor junction, a second part between each of the floating guard rings and a third part adjacent the floating guard ring furthermost from the semiconductor junction on the side of the floating guard ring distal from the semiconductor junction, the first, second and third parts all being adjacent the insulating oxide layer , wherein the surface charge compensation region extends completely between adjacent ones of the floating guard rings , and wherein the surface charge compensation region has a dopant concentration providing an amount of charge in the surface charge compensation region such that the surface of the surface charge compensation region adjacent the insulating layer is partially depleted by surface charges of the insulating layer and fully depleted when a reverse bias lower than the breakdown voltage of the device is applied to the device . forming a plurality of spaced apart concentric floating guard rings in a silicon carbide layer that surround at least a portion of a silicon carbide-based semiconductor junction; forming an insulating oxide layer on the floating guard rings ; and forming a silicon carbide surface charge compensation region having a first part between the semiconductor junction and a floating guard ring closest to the semiconductor junction, a second part between each of the floating guard rings and a third part adjacent the floating guard ring furthermost from the semiconductor junction on the side of the floating guard ring distal from the semiconductor junction, the first, second and third parts all being adjacent the insulating oxide layer , wherein the surface charge compensation region extends completely between adjacent ones of the floating guard rings , and wherein the surface charge compensation region has a dopant concentration providing an amount of charge in the surface charge compensation region such that the surface of the surface charge compensation region adjacent the insulating layer is partially depleted by surface charges of the insulating layer and fully depleted when a reverse bias lower than the breakdown voltage of the device is applied to the device .
A servo controlled stitching apparatus comprising: at least one wire retaining spool ; at least one stitching head ; means for said stitching head for feeding wire delivered to it from said spools and for cutting pulled wire into a desired section and for applying said cut section to a successive bunch of paper sheets for stitching; wire pulling means in the path of the wire being delivered from said spool to the stitching head for pulling a wire from the spool to form a slacked portion ; wherein said slacked wire defines the length of the wire being pulled by said wire pulling means ; wherein said wire pulling means comprises a pair of rollers in closest proximity at their periphery rotatably mounted on shafts which are substantially parallel, means for rotating one of said shafts , means for applying pressure across the section of wire located between said rollers and a controller means , in which controller means said slacked portion is changeably defined by said rotating means controlled by the controller means; wherein one of said rollers is formed with at least one groove along its circular periphery for protrusively locating and guiding said wire ; wherein said wire is pulled by passing between said rollers while pressure is applied between diametrically opposed points on the periphery of said wire ; wherein said rotating means rotates any of said rollers until the slacked wire defined in the controller means is pulled from the spool . at least one wire retaining spool ; at least one stitching head ; means for said stitching head for feeding wire delivered to it from said spools and for cutting pulled wire into a desired section and for applying said cut section to a successive bunch of paper sheets for stitching; wire pulling means in the path of the wire being delivered from said spool to the stitching head for pulling a wire from the spool to form a slacked portion ; wherein said slacked wire defines the length of the wire being pulled by said wire pulling means ; wherein said wire pulling means comprises a pair of rollers in closest proximity at their periphery rotatably mounted on shafts which are substantially parallel, means for rotating one of said shafts , means for applying pressure across the section of wire located between said rollers and a controller means , in which controller means said slacked portion is changeably defined by said rotating means controlled by the controller means; wherein one of said rollers is formed with at least one groove along its circular periphery for protrusively locating and guiding said wire ; wherein said wire is pulled by passing between said rollers while pressure is applied between diametrically opposed points on the periphery of said wire ; wherein said rotating means rotates any of said rollers until the slacked wire defined in the controller means is pulled from the spool .
A manufacturing method of an inkjet flatbed table which comprises a large support layer to support an ink receiver in an inkjet printing system, comprising the following steps: a) fixing a plate on top of a base unit thereby forming a part of the support layer or the support layer as a whole, wherein the plate comprising a thermoplastic polymer resin, characterized by : b) abrading the fixed plate to have a flatness on the top of the support layer less than 300 μm, wherein the support layer has an area of at least 1.5 m2.
Method for monitoring a loudspeaker line, wherein a principal module , arranged at a first point in the loudspeaker line , and multiple monitoring modules , arranged at a respective second, remote point in the loudspeaker line , communicate, wherein an impedance between the loudspeaker line and a reference earth is measured, characterized in that the principal module applies a DC voltage (Uq) to the loudspeaker line with reference to the reference earth , wherein the impedance between the loudspeaker line and the reference earth is changed by the sending communication subscriber in order to transmit a digital communication signal, and wherein the principal module sends a digital communication signal as a request, said digital communication signal being received and processed by the monitoring modules, and wherein, if a receiving monitoring module detects that it is addressed, responds to the request by sending a digital communication signal.
An output control device for an internal combustion engine for generating a drive force of a vehicle, comprising: a braking request detection unit configured to detect whether or not a braking request operation has been performed; a braking operation time calculation unit configured to calculate a braking operation time from the start of the braking request operation; an output limitation unit configured to determine whether or not the brake operation time is longer than a predetermined time and, based on the determination result, bring into effect an output limitation of the internal combustion engine when the braking operation time becomes longer than the predetermined time; characterized in further comprising an output limitation lifting unit configured to lift the output limitation of the internal combustion engine when the braking request operation is finished; and a repeat determining output limitation unit configured to bring into effect, when the braking request operation is started again before a repeat determination time elapses after the braking operation is finished, the output limitation of the internal combustion engine when the braking request operation is started. a braking request detection unit configured to detect whether or not a braking request operation has been performed; a braking operation time calculation unit configured to calculate a braking operation time from the start of the braking request operation; an output limitation unit configured to determine whether or not the brake operation time is longer than a predetermined time and, based on the determination result, bring into effect an output limitation of the internal combustion engine when the braking operation time becomes longer than the predetermined time; characterized in further comprising an output limitation lifting unit configured to lift the output limitation of the internal combustion engine when the braking request operation is finished; and a repeat determining output limitation unit configured to bring into effect, when the braking request operation is started again before a repeat determination time elapses after the braking operation is finished, the output limitation of the internal combustion engine when the braking request operation is started.
A method performed by a first network node for handling a connection between a wireless device and a wireless communications network , which wireless communications network comprises the first network node , the method comprising: storing , in the first network node , data related to the connection , and further storing, in the first network node , an identifier of the wireless device for locating the stored data later when resuming the connection , wherein the identifier is a unique identity of the wireless device within an area comprising a cell served by the first network node ; and providing the wireless device with a command to transition from a connected mode into a suspended mode, in which suspended mode the connection is suspended. storing , in the first network node , data related to the connection , and further storing, in the first network node , an identifier of the wireless device for locating the stored data later when resuming the connection , wherein the identifier is a unique identity of the wireless device within an area comprising a cell served by the first network node ; and providing the wireless device with a command to transition from a connected mode into a suspended mode, in which suspended mode the connection is suspended.
A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein: n is selected from 1, 2 and 3; p is selected from 0 and 1; each occurrence of A is independently selected from -CH= or -N=, provided not all A groups are -N=; L is selected from -NHC(O)- and -C(O)NH-; M is selected from -O- and -S-; W is selected from -C(O)NH- and -NHC(O)-; R 1 is aryl, wherein the aryl is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) -CN, (c) C 1-6 alkyl, and (d) -O-C 1-6 alkyl; R 2 is selected from: C 1-6 alkyl, C 3-6 cycloalkyl, aryl, and heterocyclyl; wherein the C 1-6 alkyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen and (b) C 3-6 cycloalkyl; and wherein each of the C 3-6 cycloalkyl of , aryl of , and heterocyclyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) -CN, and (c) C 1-6 alkyl optionally substituted with 1-3 halogens; R 3 is selected from H, halogen, and C 1-6 alkyl; aryl is an aromatic monocyclic or multicyclic ring moiety comprising 6 to 14 ring carbon atoms; and heterocyclyl is a monocyclic or bicyclic saturated, partially unsaturated or aromatic ring, wherein the ring has at least one ring heteroatom selected from oxygen, sulfur and nitrogen and at least one ring carbon atom. n is selected from 1, 2 and 3; p is selected from 0 and 1; each occurrence of A is independently selected from -CH= or -N=, provided not all A groups are -N=; L is selected from -NHC(O)- and -C(O)NH-; M is selected from -O- and -S-; W is selected from -C(O)NH- and -NHC(O)-; R 1 is aryl, wherein the aryl is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) -CN, (c) C 1-6 alkyl, and (d) -O-C 1-6 alkyl; R 2 is selected from: C 1-6 alkyl, C 3-6 cycloalkyl, aryl, and heterocyclyl; wherein the C 1-6 alkyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen and (b) C 3-6 cycloalkyl; and wherein each of the C 3-6 cycloalkyl of , aryl of , and heterocyclyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) -CN, and (c) C 1-6 alkyl optionally substituted with 1-3 halogens; C 1-6 alkyl, C 3-6 cycloalkyl, aryl, and heterocyclyl; wherein the C 1-6 alkyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen and (b) C 3-6 cycloalkyl; and wherein each of the C 3-6 cycloalkyl of , aryl of , and heterocyclyl of is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) -CN, and (c) C 1-6 alkyl optionally substituted with 1-3 halogens; R 3 is selected from H, halogen, and C 1-6 alkyl; aryl is an aromatic monocyclic or multicyclic ring moiety comprising 6 to 14 ring carbon atoms; and heterocyclyl is a monocyclic or bicyclic saturated, partially unsaturated or aromatic ring, wherein the ring has at least one ring heteroatom selected from oxygen, sulfur and nitrogen and at least one ring carbon atom.
Horse-riding stirrup comprising: - a stirrup frame which comprises a hooking portion to a stirrup leather , a first side arm and a support arm connected to each other in an incident manner to define a frame compartment engageable by a user's foot; - a second side arm comprising an articulation end pivoted to the stirrup frame about an axis of rotation (R), and a free end rotatable between a coupling configuration to the support arm in which the second arm encloses the frame compartment with the first side arm and the support arm , and a release configuration of the latter (Fig. 2), in which said second arm is spaced from the support arm to create a lateral disengagement opening of the user's foot from said compartment; wherein the second side arm comprises at least a flexible portion which in the coupling configuration presses the free end in abutment with the support arm and which, in order to achieve the release configuration, allows the second side arm to bend in part to snap disengage the free end from the support arm , for example as a result of a stress in a direction (S) opposite the first side arm , and characterized in that between the articulation end and the free end , the second side arm delimits one or more structural lightening portions , for example in the form of a recess, which form the flexible portion, wherein the flexibility of the flexible portion is adjustable through the selection of a higher/lower distribution density of said lightening portions along said arm . - a stirrup frame which comprises a hooking portion to a stirrup leather , a first side arm and a support arm connected to each other in an incident manner to define a frame compartment engageable by a user's foot; - a second side arm comprising an articulation end pivoted to the stirrup frame about an axis of rotation (R), and a free end rotatable between a coupling configuration to the support arm in which the second arm encloses the frame compartment with the first side arm and the support arm , and a release configuration of the latter (Fig. 2), in which said second arm is spaced from the support arm to create a lateral disengagement opening of the user's foot from said compartment;
A testosterone gel formulation for nasal administration, said testosterone gel formulation comprising: a) about 4.5% testosterone by weight of said gel formulation; and b) a pharmaceutically acceptable vehicle. a) about 4.5% testosterone by weight of said gel formulation; and b) a pharmaceutically acceptable vehicle.
Road finisher comprising: a material hopper for receiving paving material; a screed for compacting paving material; and a main control stand providing an operating location for an operator on the road finisher , wherein the main control stand comprises a floor area , wherein the road finisher comprises a lighting unit , wherein the lighting unit is arranged no more than 140 cm higher with respect to a vertical direction than the floor area of the main control stand , and wherein the lighting unit is arranged such that at least 60 percent of the light output emitted by the lighting unit during operation falls onto the floor area of the main control stand . a material hopper for receiving paving material; a screed for compacting paving material; and a main control stand providing an operating location for an operator on the road finisher , wherein the main control stand comprises a floor area , wherein the road finisher comprises a lighting unit , wherein the lighting unit is arranged no more than 140 cm higher with respect to a vertical direction than the floor area of the main control stand , and wherein the lighting unit is arranged such that at least 60 percent of the light output emitted by the lighting unit during operation falls onto the floor area of the main control stand .
Teriparatide or a salt thereof for use in preventing or treating osteoporosis in a human patient, characterized in that the teriparatide or a salt thereof is administered in a unit dose of 28.2 μg at a frequency of twice a week, wherein the intervals, not including the days of administration, of administration of twice a week are a 2-day interval and a 3-day interval. osteoporosis in a human patient, characterized in that the teriparatide or a salt thereof is administered in a unit dose of 28.2 μg at a frequency of twice a week, wherein the intervals, not including the days of administration, of administration of twice a week are a 2-day interval and a 3-day interval.
Torque tool, in particular torque screwdriver , with a handle and a setting body , rotatable about the longitudinal axis (L) of the handle , for setting a torque, as well as a display for a defined torque, which comprises a digit roller counter , wherein the digit roller counter has at least two digit rollers , wherein the digit roller counter is arranged in a hollow cylindrical longitudinal section of the handle , which has a viewing window through which the set torque is visible, and the digit roller counter has a passage in its central axis (ML) through which a shaft section is guided, characterised in that a carrier disc , arranged in the handle in a rotationally fixed manner, is integrated between two digit rollers (11, 12 or 12, 13) and a control gear is rotatably associated with the carrier disc , which has a drive toothing and a control toothing , and wherein a digit roller has an outer digit rim , which has a first rim section with a drive toothing as well as a second rim section with a control element , and wherein the setting body has means for transmitting a rotary movement of the setting body to the digit roller , arranged on the setting body side.