A method of producing hydrocarbons comprising: obtaining a sample from one of one or more subsurface regions: interpreting the sample to determine a noble gas signature and a hydrocarbon clumped isotope signatures for the obtained sample; generating a region of interest fingerprint having the noble gas signature and the hydrocarbon clumped isotope signature for the obtained sample; producing fluids from the one of the one or more subsurface regions, wherein the produced fluids comprise hydrocarbons; and performing reservoir surveillance on the produced fluids from the one of the one or more subsurface regions, wherein determining the hydrocarbon clumped isotope signature comprises: determining an expected concentration of isotopologues of a hydrocarbon species from the sample; modeling, using high-level ab initio calculations, an expected temperature dependence of isotopologues present in the sample; measuring a hydrocarbon clumped isotopic signature of the isotopologues present in the sample; comparing the hydrocarbon clumped isotopic signature with the expected concentration of isotopologues; determining, the current equilibrium storage temperature of the hydrocarbon species in the subsurface accumulation prior to escape to the surface; and determining a location of the subsurface accumulation. obtaining a sample from one of one or more subsurface regions: interpreting the sample to determine a noble gas signature and a hydrocarbon clumped isotope signatures for the obtained sample; generating a region of interest fingerprint having the noble gas signature and the hydrocarbon clumped isotope signature for the obtained sample; producing fluids from the one of the one or more subsurface regions, wherein the produced fluids comprise hydrocarbons; and performing reservoir surveillance on the produced fluids from the one of the one or more subsurface regions, interpreting the sample to determine a noble gas signature and a hydrocarbon clumped isotope signatures for the obtained sample; generating a region of interest fingerprint having the noble gas signature and the hydrocarbon clumped isotope signature for the obtained sample; producing fluids from the one of the one or more subsurface regions, wherein the produced fluids comprise hydrocarbons; and performing reservoir surveillance on the produced fluids from the one of the one or more subsurface regions, wherein determining the hydrocarbon clumped isotope signature comprises: determining an expected concentration of isotopologues of a hydrocarbon species from the sample; modeling, using high-level ab initio calculations, an expected temperature dependence of isotopologues present in the sample; measuring a hydrocarbon clumped isotopic signature of the isotopologues present in the sample; comparing the hydrocarbon clumped isotopic signature with the expected concentration of isotopologues; determining, the current equilibrium storage temperature of the hydrocarbon species in the subsurface accumulation prior to escape to the surface; and determining a location of the subsurface accumulation. determining an expected concentration of isotopologues of a hydrocarbon species from the sample; modeling, using high-level ab initio calculations, an expected temperature dependence of isotopologues present in the sample; measuring a hydrocarbon clumped isotopic signature of the isotopologues present in the sample; comparing the hydrocarbon clumped isotopic signature with the expected concentration of isotopologues; determining, the current equilibrium storage temperature of the hydrocarbon species in the subsurface accumulation prior to escape to the surface; and determining a location of the subsurface accumulation. <EOS>