A system for performing a titration for oral appliance therapy, comprising: a. an adjustable mandibular displacement device configured to be positioned in an oral cavity of a subject; b. a monitoring unit configured to sense physiological information from the subject during a test period; and c. a control unit comprising a processing unit and a memory operatively coupled to the processing unit , the memory having computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to: d. receive one or more physiological inputs from the monitoring unit during the test period; e. detect respiratory events during the test period using the one or more physiological inputs; f. calculate a frequency of the respiratory events; g. adjust a protrusion level of the adjustable mandibular displacement device during the test period based on the frequency of the respiratory events, at least one of a magnitude or rate of adjustment being related to the frequency of the respiratory events, wherein adjusting the protrusion level includes moving the adjustable mandibular displacement device between at least two protrusion levels; h. measure the position of the adjustable mandibular displacement device and the time that the adjustable mandibular displacement device spends at each of a plurality of positions; and i. evaluate an outcome of oral appliance therapy based on the plurality of positions of the adjustable mandibular displacement device during the test period and an amount of time the adjustable mandibular displacement device spends at each of the plurality of positions and the physiological information during the test period. a. an adjustable mandibular displacement device configured to be positioned in an oral cavity of a subject; b. a monitoring unit configured to sense physiological information from the subject during a test period; and c. a control unit comprising a processing unit and a memory operatively coupled to the processing unit , the memory having computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to: d. receive one or more physiological inputs from the monitoring unit during the test period; e. detect respiratory events during the test period using the one or more physiological inputs; f. calculate a frequency of the respiratory events; g. adjust a protrusion level of the adjustable mandibular displacement device during the test period based on the frequency of the respiratory events, at least one of a magnitude or rate of adjustment being related to the frequency of the respiratory events, wherein adjusting the protrusion level includes moving the adjustable mandibular displacement device between at least two protrusion levels; h. measure the position of the adjustable mandibular displacement device and the time that the adjustable mandibular displacement device spends at each of a plurality of positions; and i. evaluate an outcome of oral appliance therapy based on the plurality of positions of the adjustable mandibular displacement device during the test period and an amount of time the adjustable mandibular displacement device spends at each of the plurality of positions and the physiological information during the test period. <EOS>