mhurhangee/patent-ind-claim-en huggingface dataset:
A ruthenium complex having the following formula : [RuX(CO) 2 (PNP)]Y wherein X represents a hydride, Y represents a counter anion, and PNP represents a tridentate ligand having the following formula : wherein in the formula , R 1 , R 2 , R 1' and R 2' , each independently represent an alkyl group, an aryl group, an aralkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, an aralkyloxy group, a heterocyclic group or an amino group, and among the groups, an alkyl group, an aryl group, an aralkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, an aralkyloxy group and a heterocyclic group may have substituent (s) ; R 1 and R 2 , and R 1' and R 2' each independently may bind to each other to form a ring with the adjacent phosphorus atom; Q 1 and Q 2 each independently represent an optionally substituted alkanediyl group or an optionally substituted aralkylene group; and CO represents carbon monoxide, and wherein "alkyl"and "alkenyl" include linear, branched and cyclic groups, also in composed terms like "alkoxy" and "alkanediyl". wherein X represents a hydride, Y represents a counter anion, and PNP represents a tridentate ligand having the following formula : wherein in the formula , R 1 , R 2 , R 1' and R 2' , each independently represent an alkyl group, an aryl group, an aralkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, an aralkyloxy group, a heterocyclic group or an amino group, and among the groups, an alkyl group, an aryl group, an aralkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, an aralkyloxy group and a heterocyclic group may have substituent (s) ; R 1 and R 2 , and R 1' and R 2' each independently may bind to each other to form a ring with the adjacent phosphorus atom; Q 1 and Q 2 each independently represent an optionally substituted alkanediyl group or an optionally substituted aralkylene group; and CO represents carbon monoxide, and wherein "alkyl"and "alkenyl" include linear, branched and cyclic groups, also in composed terms like "alkoxy" and "alkanediyl".
A process for the preparation of Crisaborole of formula (I) comprising the steps of: a) treating 4-(4-halo-3-hydroxymethyl-phenoxy)-benzonitrile of formula (V) with trityl chloride in the presence of base and suitable solvent to give 4-{4-halo-3-[(trityloxymethyl)]phenoxy}benzonitrile of formula (IV); b) reacting of compound of formula (IV) with pinacolborane or bis(pinacolato)diboron in the presence of a transition metal catalyst and a base in suitable solvent to give 4-[4-(4,4,5,5-tetramethyl- dioxaborolan-2-yl)-3-trityloxymethyl-phenoxy]-benzontirile of formula (III); c) optionally transesterifying the compound of formula (III) with diethanolamine in suitable solvent to provide the compound of formula (II); d) deprotecting and cyclizing the compound of formula (II) or (III) in the presence of suitable acid and solvent to give Crisaborole of formula (I); and e) optionally purifying Crisaborole of formula (I). a) treating 4-(4-halo-3-hydroxymethyl-phenoxy)-benzonitrile of formula (V) with trityl chloride in the presence of base and suitable solvent to give 4-{4-halo-3-[(trityloxymethyl)]phenoxy}benzonitrile of formula (IV); b) reacting of compound of formula (IV) with pinacolborane or bis(pinacolato)diboron in the presence of a transition metal catalyst and a base in suitable solvent to give 4-[4-(4,4,5,5-tetramethyl- dioxaborolan-2-yl)-3-trityloxymethyl-phenoxy]-benzontirile of formula (III); c) optionally transesterifying the compound of formula (III) with diethanolamine in suitable solvent to provide the compound of formula (II); d) deprotecting and cyclizing the compound of formula (II) or (III) in the presence of suitable acid and solvent to give Crisaborole of formula (I); and e) optionally purifying Crisaborole of formula (I).
A parallel passage fluid contactor structure comprising one or more segments , each segment comprising: a plurality of substantially parallel fluid flow passages oriented in an axial direction; cell walls situated between each adjacent one of said fluid flow passages, each said cell wall having at least two opposite cell wall surfaces, and comprising at least one active compound that is operable to interact with a fluid contained within or passed through the passages, the active compound being comprised on or in a said cell wall surface; and a plurality of axially continuous, axially oriented, filaments that are thermally conductive and/or electrically conductive for transfer of thermal energy from said active compound; and at least one segment additionally comprises transversely continuous filaments that are thermally conductive and / or electrically conductive and oriented in a transverse direction, substantially perpendicular to said axial direction, characterized in that both the axially continuous filaments and the transversely continuous filaments are embedded within said cell walls in direct contact with said at least one active compound on or in said cell wall surface, and are operable to transfer thermal energy between said at least one active compound and said conductive filaments. a plurality of substantially parallel fluid flow passages oriented in an axial direction; cell walls situated between each adjacent one of said fluid flow passages, each said cell wall having at least two opposite cell wall surfaces, and comprising at least one active compound that is operable to interact with a fluid contained within or passed through the passages, the active compound being comprised on or in a said cell wall surface; and a plurality of axially continuous, axially oriented, filaments that are thermally conductive and/or electrically conductive for transfer of thermal energy from said active compound; and at least one segment additionally comprises transversely continuous filaments that are thermally conductive and / or electrically conductive and oriented in a transverse direction, substantially perpendicular to said axial direction, characterized in that both the axially continuous filaments and the transversely continuous filaments are embedded within said cell walls in direct contact with said at least one active compound on or in said cell wall surface, and are operable to transfer thermal energy between said at least one active compound and said conductive filaments.
A downhole tool , such as a circulating sub or a cleaning tool, for cleaning a borehole , comprising a housing defining a longitudinal direction, a first fluid conduit extending from an opening in a first end of the housing to an opening in a second end of the housing , and an activation mechanism configured to at least activate the downhole tool , the housing further has an outer side surface facing an inner wall of the borehole , when positioned in the borehole , and an inner side surface facing the first fluid conduit , the first fluid conduit is configured to lead a drilling fluid from the first end to the second end when the downhole tool is not activated, the housing further has at least a second fluid conduit extending from at least a first opening connected to the first fluid conduit to a second opening arranged in the outer side surface , at least a first nozzle is arranged at the second opening of the at least second fluid conduit , the at least second fluid conduit is placed in a first acute angle (α) relative to at least the longitudinal direction so that the at least second fluid conduit substantially extends towards one of the first and second ends , and wherein at least a third fluid conduit extends from a third opening connected to the first fluid conduit to a fourth opening arranged in the outer side surface , characterised in that at least a second nozzle is arranged at the fourth opening of the at least third fluid conduit , wherein the at least third fluid conduit is placed in a second acute angle (β) relative to at least the longitudinal direction so that the at least third fluid conduit substantially extends towards one of the first and second ends and wherein said first and second acute angles α, β are between 30° and 65°.
Method for producing a microsystem with pixels, having the steps: - providing a silicon wafer; - producing a thermal silicon oxide layer on the surface of the silicon wafer as a base layer with a thickness between 200 nm and 1000 nm by oxidation of the silicon wafer; - producing a silicon oxide thin layer directly on the base layer as a carrier layer with a thickness of 100 nm to 700 nm by a thermal deposition method; - producing a platinum layer directly on the carrier layer with a thermal deposition method with a thickness of 40 nm to 200 nm, through which an intermediate product having the silicon wafer, the base layer , the carrier layer and the platinum layer is produced; - cooling of the intermediate product to room temperature; - pixel-type structuring of the platinum layer by removing superfluous areas of the platinum layer, through which bottom electrodes of the pixels are formed pixel-shaped on the carrier layer by the remaining areas of the platinum layer; - removing material on the side of the silicon wafer facing away from the base layer , so that a frame remains and a membrane formed by the base layer and the carrier layer is tensioned by the frame ; - producing the microsystem . - providing a silicon wafer; - producing a thermal silicon oxide layer on the surface of the silicon wafer as a base layer with a thickness between 200 nm and 1000 nm by oxidation of the silicon wafer; - producing a silicon oxide thin layer directly on the base layer as a carrier layer with a thickness of 100 nm to 700 nm by a thermal deposition method; - producing a platinum layer directly on the carrier layer with a thermal deposition method with a thickness of 40 nm to 200 nm, through which an intermediate product having the silicon wafer, the base layer , the carrier layer and the platinum layer is produced; - cooling of the intermediate product to room temperature; - pixel-type structuring of the platinum layer by removing superfluous areas of the platinum layer, through which bottom electrodes of the pixels are formed pixel-shaped on the carrier layer by the remaining areas of the platinum layer; - removing material on the side of the silicon wafer facing away from the base layer , so that a frame remains and a membrane formed by the base layer and the carrier layer is tensioned by the frame ; - producing the microsystem .
A method for determining a susceptibility of a sample of at least one material, which sample includes a welded area , to reheat cracking, the method comprising: measuring a length of the sample ; applying a first stress to the sample to achieve a predetermined elongation of the sample ; exposing the elongated sample to a predefined heat treatment ; applying a second stress to the elongated sample until the sample breaks at least into two different pieces ; and determining from the broken sample the susceptibility of the sample to reheat cracking; wherein the step of determining comprises: analyzing at least one fracture surface of the broken sample with a scanning electron microscope, the broken sample having a chemical composition of 2.25Cr 1Mo 0.25V, to identify a first area (E) of crack damage and a second area (D) of fast fracture, wherein the first area (E) of crack damage includes a third area (F) of intergranular pure brittle crack damage; and classifying the sample as susceptible to reheat cracking when at least one of the following conditions are met: the third area (F) is higher than about 0% of the first area (E); the first area (E) of crack damage is higher than about 10% of a total area of the fracture surface of the broken sample . measuring a length of the sample ; applying a first stress to the sample to achieve a predetermined elongation of the sample ; exposing the elongated sample to a predefined heat treatment ; applying a second stress to the elongated sample until the sample breaks at least into two different pieces ; and determining from the broken sample the susceptibility of the sample to reheat cracking; wherein the step of determining comprises: analyzing at least one fracture surface of the broken sample with a scanning electron microscope, the broken sample having a chemical composition of 2.25Cr 1Mo 0.25V, to identify a first area (E) of crack damage and a second area (D) of fast fracture, wherein the first area (E) of crack damage includes a third area (F) of intergranular pure brittle crack damage; and classifying the sample as susceptible to reheat cracking when at least one of the following conditions are met: the third area (F) is higher than about 0% of the first area (E); the first area (E) of crack damage is higher than about 10% of a total area of the fracture surface of the broken sample . analyzing at least one fracture surface of the broken sample with a scanning electron microscope, the broken sample having a chemical composition of 2.25Cr 1Mo 0.25V, to identify a first area (E) of crack damage and a second area (D) of fast fracture, wherein the first area (E) of crack damage includes a third area (F) of intergranular pure brittle crack damage; and classifying the sample as susceptible to reheat cracking when at least one of the following conditions are met: the third area (F) is higher than about 0% of the first area (E); the first area (E) of crack damage is higher than about 10% of a total area of the fracture surface of the broken sample .
A serum amyloid P (SAP) agonist for use in treating myelofibrosis, or improving the efficacy of an anti-cancer therapeutic, in a patient with myelofibrosis, wherein said patient is to be administered a therapeutically effective amount of said serum amyloid P (SAP) agonist; wherein the SAP agonist is an SAP polypeptide; wherein the SAP agonist is to be administered one or more times in an initial loading dose during a first week of administration followed by one time every one to four weeks, and wherein each administration of the SAP agonist is 0.1-40 mg/kg.
A residual gas volume measuring device for measuring the volume of residual gas (G) in a container (B), comprising: a puncture member having a first and a second communication path formed therein and connecting a penetrating portion and a coupling portion thereof together, the penetrating portion being located inside the container (B) and the coupling portion being located outside the container (B) when the puncture member is in a penetrating position where an end of the puncture member penetrates into the container (B); an injection section coupled to the first communication path at the coupling portion and configured to inject a liquid into the container (B); a discharging section coupled to the second communication path at the coupling portion and configured to discharge the residual gas (G) purged by the injected liquid; a measurement section configured to measure the volume of the residual gas (G) discharged by the discharging section ; characterized in that the first and second communication paths each have an opening at the respective penetrating portion , the opening at the penetrating portion of the first communication path being located deeper in the container (B) than is the opening at the penetrating portion of the second communication path when the puncture member is in the penetrating position. a puncture member having a first and a second communication path formed therein and connecting a penetrating portion and a coupling portion thereof together, the penetrating portion being located inside the container (B) and the coupling portion being located outside the container (B) when the puncture member is in a penetrating position where an end of the puncture member penetrates into the container (B); an injection section coupled to the first communication path at the coupling portion and configured to inject a liquid into the container (B); a discharging section coupled to the second communication path at the coupling portion and configured to discharge the residual gas (G) purged by the injected liquid; a measurement section configured to measure the volume of the residual gas (G) discharged by the discharging section ; characterized in that the first and second communication paths each have an opening at the respective penetrating portion , the opening at the penetrating portion of the first communication path being located deeper in the container (B) than is the opening at the penetrating portion of the second communication path when the puncture member is in the penetrating position.
The compound 2-(cyclohexylamino)-N-(2,5-dihydroxyphenyl)acetamide according to the formula:
A photocurable composition for a support material for an inkjet 3D printer comprising a water-soluble ethylenically unsaturated monomer containing an ionic group and a counter ion, wherein a water content is not more than 10 mass% in 100 mass% of said photocurable composition for a support material, wherein at least potassium (meth) acrylate is used as the water-soluble ethylenically unsaturated monomer, and wherein the photocurable composition for a support material further comprises a glycol as solvent. wherein a water content is not more than 10 mass% in 100 mass% of said photocurable composition for a support material, wherein at least potassium (meth) acrylate is used as the water-soluble ethylenically unsaturated monomer, and wherein the photocurable composition for a support material further comprises a glycol as solvent.
A method for a session management function entity, comprising obtaining (S41) policy related information and charging related information, generating (S42) a pre-rule based on said policy related information and said charging related information, wherein said pre-rule is a partially generated rule of a rule related to local traffic offloading with respect to a user plane function entity under control of an intermediate session management function entity, wherein said pre-rule is to be completed by said intermediate session management function entity with access network related information needed from an access network, and transmitting (S43) said pre-rule to said intermediate session management function entity; wherein said pre-rule comprises references to information that said intermediate session management function entity is to determine locally in order to generate said rule related to local traffic offloading to be transmitted to said user plane function entity under control of said intermediate session management function entity. obtaining (S41) policy related information and charging related information, generating (S42) a pre-rule based on said policy related information and said charging related information, wherein said pre-rule is a partially generated rule of a rule related to local traffic offloading with respect to a user plane function entity under control of an intermediate session management function entity, wherein said pre-rule is to be completed by said intermediate session management function entity with access network related information needed from an access network, and transmitting (S43) said pre-rule to said intermediate session management function entity; wherein said pre-rule comprises references to information that said intermediate session management function entity is to determine locally in order to generate said rule related to local traffic offloading to be transmitted to said user plane function entity under control of said intermediate session management function entity.
A surgical apparatus for positioning within a tissue tract accessing an underlying body cavity, which comprises: a proximal member including an inflatable member adjustable to a plurality of radial dimensions; a distal member axially aligned with respect to the proximal member; a flexible sleeve extending between the proximal and distal members and defining a passage for reception of object; and a C-shaped rigid ring member defining an outer circumferential recessed portion for receiving the inflatable member therein, the ring member having a radial dimension corresponding to a minimal radial dimension of the proximal member whereby the proximal member is prevented from contracting below its minimal radial dimension during deflation of the inflation member and is forced to expand in a radially outwardly direction upon inflation of the inflatable member. a proximal member including an inflatable member adjustable to a plurality of radial dimensions; a distal member axially aligned with respect to the proximal member; a flexible sleeve extending between the proximal and distal members and defining a passage for reception of object; and a C-shaped rigid ring member defining an outer circumferential recessed portion for receiving the inflatable member therein, the ring member having a radial dimension corresponding to a minimal radial dimension of the proximal member whereby the proximal member is prevented from contracting below its minimal radial dimension during deflation of the inflation member and is forced to expand in a radially outwardly direction upon inflation of the inflatable member.
A routing control method performed by an OpenFlow controller , OFC, in software defined networking, the method comprising: receiving a data packet reported by an OpenFlow switch, OFS; determining that the data packet is a repeated packet; and determining that a routing policy of the data packet does not need to be calculated; wherein for repeated data packets the OFC calculates a routing policy only once; wherein determining that the data packet is a repeated packet comprises: determining, according to a key value stored in a cache of the controller, that the data packet is a repeated packet, wherein the key value comprises a data packet feature value and further comprises a processing moment; and wherein determining according to a key value, that the data packet is a repeated packet comprises: comparing a feature value of the data packet with the data packet feature value in the key value for determining that the data packet hits the cache; and if the data packet hits the cache, determining that the data packet is a repeated packet when a time interval between a current moment and the processing moment in the key value is less than or equal to a preset time value, wherein the preset time value is a time value less than or equal to a flow table valid time. receiving a data packet reported by an OpenFlow switch, OFS; determining that the data packet is a repeated packet; and determining that a routing policy of the data packet does not need to be calculated; wherein for repeated data packets the OFC calculates a routing policy only once; wherein determining that the data packet is a repeated packet comprises: determining, according to a key value stored in a cache of the controller, that the data packet is a repeated packet, wherein the key value comprises a data packet feature value and further comprises a processing moment; and wherein determining according to a key value, that the data packet is a repeated packet comprises: comparing a feature value of the data packet with the data packet feature value in the key value for determining that the data packet hits the cache; and if the data packet hits the cache, determining that the data packet is a repeated packet when a time interval between a current moment and the processing moment in the key value is less than or equal to a preset time value, wherein the preset time value is a time value less than or equal to a flow table valid time. comparing a feature value of the data packet with the data packet feature value in the key value for determining that the data packet hits the cache; and if the data packet hits the cache, determining that the data packet is a repeated packet when a time interval between a current moment and the processing moment in the key value is less than or equal to a preset time value, wherein the preset time value is a time value less than or equal to a flow table valid time.