A method of preparing a compound of the formula, wherein: n is 1, 2 or 3; m is 1; t is 0, 1 or 2; y is 1 or 2; z is 0, 1 or 2; E is O; X 1 is CR 1 ; X 2 is O; X 3 is -NH; X 4 is CR 4 R 5 , CH 2 CR 4 R 5 or CH 2 -(C 1 -C 6 ) alkyl-CR 4 R 5 ; X 5 is a direct bond; R 1 is H; R 4 and R 5 are independently selected from H and (C 1 -C 6 )alkyl; or are taken together with the carbon to which they are attached to form a spiro (C 3 -C 10 )cycloalkyl ring or spiro (C 3 -C 10 )cycloalkoxy ring; R 6 is H; A 1 is (C 2 -C 9 )heteroaryl optionally substituted with one or more substituents selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally substituted by one to three halo; (C 1 -C 6 )alkenyl, amino, (C 1 -C 6 )alkylamino, (C 1 -C 6 )dialkylamino, (C 1 -C 6 )alkoxy, nitro, CN, -OH, (C 1 -C 6 )alkyloxy optionally substituted by one to three halo; (C1-C 6 )alkoxycarbonyl, and (C 1 -C 6 ) alkylcarbonyl; and A 2 is (C 6 -C 12 )aryl optionally substituted with one or more substituents selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally substituted by one to three halo; (C 1 -C 6 )alkylenyl, amino, (C 1 -C 6 ) alkylamino, (C 1 -C 6 )dialkylamino, (C 1 -C 6 )alkoxy, O(C 3 -C 6 cycloalkyl), (C 3 -C 6 ) cycloalkoxy, nitro, CN, OH, (C 1 -C 6 )alkyloxy optionally substituted by one to three halo; (C 3 -C 6 ) cycloalkyl, (C 1 -C 6 ) alkoxycarbonyl, (C 1 -C 6 ) alkylcarbonyl, and (C 1 -C 6 ) haloalkyl; with the proviso that the sum of n + t + y + z is not greater than 6; the method comprising reacting the compound of Formula II with a compound of Formula III wherein n, t, y, z, R 6 , X 4 , A 1 , X 5 and A 2 are as defined above. n is 1, 2 or 3; m is 1; t is 0, 1 or 2; y is 1 or 2; z is 0, 1 or 2; E is O; X 1 is CR 1 ; X 2 is O; X 3 is -NH; X 4 is CR 4 R 5 , CH 2 CR 4 R 5 or CH 2 -(C 1 -C 6 ) alkyl-CR 4 R 5 ; X 5 is a direct bond; R 1 is H; R 4 and R 5 are independently selected from H and (C 1 -C 6 )alkyl; or are taken together with the carbon to which they are attached to form a spiro (C 3 -C 10 )cycloalkyl ring or spiro (C 3 -C 10 )cycloalkoxy ring; R 6 is H; A 1 is (C 2 -C 9 )heteroaryl optionally substituted with one or more substituents selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally substituted by one to three halo; (C 1 -C 6 )alkenyl, amino, (C 1 -C 6 )alkylamino, (C 1 -C 6 )dialkylamino, (C 1 -C 6 )alkoxy, nitro, CN, -OH, (C 1 -C 6 )alkyloxy optionally substituted by one to three halo; (C1-C 6 )alkoxycarbonyl, and (C 1 -C 6 ) alkylcarbonyl; and A 2 is (C 6 -C 12 )aryl optionally substituted with one or more substituents selected from the group consisting of halo, (C 1 -C 6 )alkyl optionally substituted by one to three halo; (C 1 -C 6 )alkylenyl, amino, (C 1 -C 6 ) alkylamino, (C 1 -C 6 )dialkylamino, (C 1 -C 6 )alkoxy, O(C 3 -C 6 cycloalkyl), (C 3 -C 6 ) cycloalkoxy, nitro, CN, OH, (C 1 -C 6 )alkyloxy optionally substituted by one to three halo; (C 3 -C 6 ) cycloalkyl, (C 1 -C 6 ) alkoxycarbonyl, (C 1 -C 6 ) alkylcarbonyl, and (C 1 -C 6 ) haloalkyl; with the proviso that the sum of n + t + y + z is not greater than 6; the method comprising reacting the compound of Formula II with a compound of Formula III wherein n, t, y, z, R 6 , X 4 , A 1 , X 5 and A 2 are as defined above. <EOS>