mhurhangee/patent-ind-claim-en huggingface dataset:
An anti-CD38 antibody for use in treating multiple myeloma in a subject, wherein the treatment comprises administration of the anti-CD38 antibody in combination with carfilzomib, wherein the subject has relapsed after at least two prior therapies for multiple myeloma with bortezomib, thalidomide, and/or lenalidomide, or has been refractory to prior therapy for multiple myeloma, wherein the anti-CD38 antibody comprises a heavy chain comprising three sequential CDRs having amino acid sequences of SEQ ID NOs: 13, 81, and 15, and a light chain comprising three sequential CDRs having amino acid sequences of SEQ ID NOs: 16, 17 and 18.
An epilator comprising at least one plucking cylinder for contacting the skin of a user and for removing hair from the skin of the user, a drive unit for driving the at least one plucking cylinder , a control unit for controlling movement of the at least one plucking cylinder , and at least one detector for detecting approximation of the at least one plucking cylinder to the skin and/or contact of the at least one plucking cylinder with the skin , wherein the detector is coupled to the control unit for transmitting a signal to the control unit and wherein the control unit is designed and arranged such that it controls actuation of the drive unit and/or of the at least one plucking cylinder depending on the signal received from the detector , characterized in that the control unit comprises at least one regulator for tuning the speed of the drive unit and in that the detector comprises a sensor measuring the resistance to actuation of the at least one plucking cylinder and/or the current consumption of the drive unit , wherein the control unit is designed and arranged such that the at least one regulator increases the speed of the drive unit upon detection of an increased resistance and/or current consumption by the sensor and that the at least one regulator decreases the speed of the drive unit upon detection of a decreased resistance and/or current consumption by the sensor .
Device comprising a filling unit for filling containers with a product, which filling unit is provided with at least one flap which is displaceable between an open position in which a container situated underneath can be filled with product falling from a filling chamber from the filling unit and a closed position for closing the filling chamber so that the containers can be filled in batches using the filling unit, in which the device is furthermore provided with a guide unit for guiding the product falling from the filling chamber into the container, in which the guide unit is displaceable in the direction of the container situated underneath, characterised in that the filling unit is displaceable into the guide unit in order to press down the product in the container.
A compound of formula (I), Ar 1 -NH-CO-NH-C 6 H 4 -SO 2 -O-C 6 H 4 -NH-CO-NH-Ar 2 (I), wherein Ar 1 and Ar 2 independently of one another are an unsubstituted or substituted phenyl group, naphthyl group and/or heteroaryl group.
Use of a holder for connecting a weatherboard to a profile frame of a window or door, wherein the holder comprises two connecting elements oriented opposite to one another and the first connecting element has a substantially circular cross-section and allows a rotary movement about an axis in the connected state and the second connecting element allows only a rigid connection, and wherein the holder is arranged between the profile frame and the weatherboard and is anchored on the side of the profile frame in an opening prepared therein by the second connecting element , characterized in that the anchoring is implemented by hooking into a water slot or latching into a bore .
A method, executed by at least one processor of a computer , comprising: receiving a first set of test patterns generated for a first circuit design, a second circuit design, and a set of faults to be used for test pattern generation for the second circuit design; analyzing the first circuit design and the second circuit design to determine part of the second circuit design structurally similar to part of the first circuit design; the method is characterised by modifying the first set of test patterns to generate a second set of test patterns for the second circuit design, the modifying comprising reusing values of bits in the first set of test patterns associated with the part of the first circuit design as values of bits in the second set of test patterns associated with the part of the second circuit design; performing fault simulation on the second circuit design using the second set of test patterns and the set of faults to determine a subset of faults in the set of faults that cannot be detected by the second set of test patterns; performing test pattern generation for the subset of faults to generate a third set of test patterns for the second circuit design; and storing the second set of test patterns and the third set of test patterns in a non-transitory computer-readable media. receiving a first set of test patterns generated for a first circuit design, a second circuit design, and a set of faults to be used for test pattern generation for the second circuit design; analyzing the first circuit design and the second circuit design to determine part of the second circuit design structurally similar to part of the first circuit design; the method is characterised by modifying the first set of test patterns to generate a second set of test patterns for the second circuit design, the modifying comprising reusing values of bits in the first set of test patterns associated with the part of the first circuit design as values of bits in the second set of test patterns associated with the part of the second circuit design; performing fault simulation on the second circuit design using the second set of test patterns and the set of faults to determine a subset of faults in the set of faults that cannot be detected by the second set of test patterns; performing test pattern generation for the subset of faults to generate a third set of test patterns for the second circuit design; and storing the second set of test patterns and the third set of test patterns in a non-transitory computer-readable media.
In combination a wear indicator and a component of a gas turbine engine, wherein the wear indicator is secured to a surface of the component of the gas turbine engine, the wear indicator comprising: a first component including: a first plate ; a second plate opposite the first plate ; a plurality of wires extending from first plate to the second plate , wherein the first plate is electrically connected to the second plate through the plurality of wires ; and a non-conductive potting material configured to partially fill the first component and fill voids between the plurality of wires , such that the plurality of wires are electrically insulated from each other by the non-conductive potting material ; wherein the first plate and the second plate are separated by a gap (D2), the gap (D2) keeping the first plate electrically separate from the second plate . a first plate ; a second plate opposite the first plate ; a plurality of wires extending from first plate to the second plate , wherein the first plate is electrically connected to the second plate through the plurality of wires ; and a non-conductive potting material configured to partially fill the first component and fill voids between the plurality of wires , such that the plurality of wires are electrically insulated from each other by the non-conductive potting material ; wherein the first plate and the second plate are separated by a gap (D2), the gap (D2) keeping the first plate electrically separate from the second plate .
A process for preparation of Sugammadex comprising: a. Mixing of γ-cyclodextrin with CX 4 , in the presence of triphenylphosphine and N-methyl-2-pyrrolidone; b. Treating the reaction product with a base to provide corresponding 6-per-deoxy-6-per-halo-γ-cyclodextrin compound of formula , wherein X is Cl or Br or I; c. Reacting compound of formula with 3-mercaptopropionic acid in the presence of a sodium base to provide Sugammadex of formula , a. Mixing of γ-cyclodextrin with CX 4 , in the presence of triphenylphosphine and N-methyl-2-pyrrolidone; b. Treating the reaction product with a base to provide corresponding 6-per-deoxy-6-per-halo-γ-cyclodextrin compound of formula , wherein X is Cl or Br or I; c. Reacting compound of formula with 3-mercaptopropionic acid in the presence of a sodium base to provide Sugammadex of formula ,
A method of handling communication, performed by a communication device of a wireless communication system , wherein the communication device is configured with a plurality of frequency bands (SB1-SB5, BWP1-BWP5), wherein the plurality of frequency bands (SB1-SB5, BWP1-BWP5) correspond to an unlicensed spectrum, the method comprising: receiving a downlink, DL hereafter, control signal from a network of the wireless communication system via a first frequency band (SB1, BWP1) among the plurality of frequency bands (SB1-SB5, BWP1-BWP5), wherein the DL control signal indicates whether at least one of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein each of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is a sub-band (SB1-SB5) comprised in a bandwidth part, BWP hereafter, of a cell, or each of the plurality of frequency bands is a BWP (BWP1-BWP5) of a cell, wherein the DL control signal comprises assistance information indicating whether each of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein the assistance information comprises a bitmap indicating whether at least one of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein the communication device is configured with a grant resource in a second frequency band among the plurality of frequency bands (SB1-SB5, BWP1-BWP5), wherein the grant resource is triggered when the second frequency band in which the grant resource is configured is determined to be not available, wherein the communication device performs an autonomous uplink transmission in the triggered grant resource . receiving a downlink, DL hereafter, control signal from a network of the wireless communication system via a first frequency band (SB1, BWP1) among the plurality of frequency bands (SB1-SB5, BWP1-BWP5), wherein the DL control signal indicates whether at least one of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein each of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is a sub-band (SB1-SB5) comprised in a bandwidth part, BWP hereafter, of a cell, or each of the plurality of frequency bands is a BWP (BWP1-BWP5) of a cell, wherein the DL control signal comprises assistance information indicating whether each of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein the assistance information comprises a bitmap indicating whether at least one of the plurality of frequency bands (SB1-SB5, BWP1-BWP5) is available or not available, wherein the communication device is configured with a grant resource in a second frequency band among the plurality of frequency bands (SB1-SB5, BWP1-BWP5), wherein the grant resource is triggered when the second frequency band in which the grant resource is configured is determined to be not available, wherein the communication device performs an autonomous uplink transmission in the triggered grant resource .
A method of writing data in a storage system that includes a first type of storage device and a second type of storage device , the method comprising: selecting, for one or more unprocessed write requests, a target storage device type from the first type of storage device and the second type of storage device ; responsive to selecting the first type of storage device , issuing, by a storage array controller , a first group of write requests to the first type of storage device , the first group of write requests addressed to one or more locations selected in dependence upon an expected address translation to be performed by the first type of storage device ; and responsive to selecting the second type of storage device , issuing, by the storage array controller , a second group of write requests to the second type of storage device , the second group of write requests addressed to one or more locations selected in dependence upon a layout of memory in the second type of storage device , wherein: issuing the second group of write requests to the second type of storage device comprises issuing two or more of the second group of write requests to the second type of storage device in parallel to a plurality of erase blocks within the second type of storage device , and the storage array controller addresses the second type of storage device directly without internal address translation by the second type of storage device . selecting, for one or more unprocessed write requests, a target storage device type from the first type of storage device and the second type of storage device ; responsive to selecting the first type of storage device , issuing, by a storage array controller , a first group of write requests to the first type of storage device , the first group of write requests addressed to one or more locations selected in dependence upon an expected address translation to be performed by the first type of storage device ; and responsive to selecting the second type of storage device , issuing, by the storage array controller , a second group of write requests to the second type of storage device , the second group of write requests addressed to one or more locations selected in dependence upon a layout of memory in the second type of storage device , wherein: issuing the second group of write requests to the second type of storage device comprises issuing two or more of the second group of write requests to the second type of storage device in parallel to a plurality of erase blocks within the second type of storage device , and the storage array controller addresses the second type of storage device directly without internal address translation by the second type of storage device . issuing the second group of write requests to the second type of storage device comprises issuing two or more of the second group of write requests to the second type of storage device in parallel to a plurality of erase blocks within the second type of storage device , and the storage array controller addresses the second type of storage device directly without internal address translation by the second type of storage device .
A medical assembly, comprising: - a transparent package , called outer package, delimiting a chamber, and - a package , called inner package, housed in said chamber of the outer package , said inner package comprising at least a first and a second transparent package part each having at least one cavity for receiving a medical object, and a sealing sheet , at least partially opacifying, comprising two parts that are applied on the two package parts so as to close said cavities , characterized in that the two package parts of the inner package are folded toward one another in the direction of a facing arrangement of the two parts of said sealing sheet applied on the two package parts of the inner package . - a transparent package , called outer package, delimiting a chamber, and - a package , called inner package, housed in said chamber of the outer package ,
A method for the continuous multi-stage manufacture of an end-capped polycarbonate comprising, i) preparing a monomer mixture in a monomer mixing stage by mixing bisphenol A, diphenyl carbonate and optionally a transesterification catalyst in at least one monomer mixing device, ii) preparing a carbonate oligomer in an oligomerisation stage by reacting said monomer mixture in at least one oligomerisation reactor, iii) preparing the polycarbonate in a polymerisation stage by further reacting the carbonate oligomer of the oligomerisation stage in at least one polymerisation reactor, wherein, an end-capping agent different from phenol and having a single phenolic hydroxy group is added to the monomer mixture in the monomer mixing stage and/or to at least one oligomerisation reactor in the oligomerisation stage i) preparing a monomer mixture in a monomer mixing stage by mixing bisphenol A, diphenyl carbonate and optionally a transesterification catalyst in at least one monomer mixing device, ii) preparing a carbonate oligomer in an oligomerisation stage by reacting said monomer mixture in at least one oligomerisation reactor, iii) preparing the polycarbonate in a polymerisation stage by further reacting the carbonate oligomer of the oligomerisation stage in at least one polymerisation reactor,
An overcurrent protection device for a circuit to be monitored, having at least one trigger unit, which is configured for an interruption of the circuit in at least one trigger situation and which comprises at least one conductor section which is configured for a conduction of a current to be monitored, at least one conductive trigger element , which comprises at least one thermo magnetically-shiftable material configured for a magnetically change in dependence on the temperature induced by a current that flows through the conductor section, a conductive magnetic module , a conductive magnetic core , said conductive magnetic module being movable between a first position faced against and in electrical contact with said conductive trigger element permitting the conduction of the current through the conductor section and a second position faced against said conductive magnetic core breaking the conduction of the current through the conductor section by opening the conductor section, as a result of a magnetic attraction force of said conductive magnetic core .
An image forming apparatus comprising: a storage in which is stored a color conversion table; an image former to print a compensation chart corresponding to the color conversion table; a scanner to scan the printed compensation chart; and a changer to: recognize a range of brightness that the image former is able to currently provide to an image to be printed using the scanned compensation chart, generate a gamma curve that uniformly distributes an input gray scale based on the recognized range of brightness, and change the color conversion table based on the generated gamma curve; wherein the color conversion table is configured to convert colors in an RGB color space into colors in a CMYK color space. a storage in which is stored a color conversion table; an image former to print a compensation chart corresponding to the color conversion table; a scanner to scan the printed compensation chart; and a changer to: recognize a range of brightness that the image former is able to currently provide to an image to be printed using the scanned compensation chart, generate a gamma curve that uniformly distributes an input gray scale based on the recognized range of brightness, and change the color conversion table based on the generated gamma curve; recognize a range of brightness that the image former is able to currently provide to an image to be printed using the scanned compensation chart, generate a gamma curve that uniformly distributes an input gray scale based on the recognized range of brightness, and change the color conversion table based on the generated gamma curve; wherein the color conversion table is configured to convert colors in an RGB color space into colors in a CMYK color space.
A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method comprising: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise ester crosslinks formed as byproducts during the amide crosslinking, and wherein the crosslinked glycosaminoglycan molecules are crosslinked by a non-carbohydrate based di- or multi-nucleophile crosslinker or diaminotrehalose together with a glycosaminoglycan; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking. i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise ester crosslinks formed as byproducts during the amide crosslinking, and wherein the crosslinked glycosaminoglycan molecules are crosslinked by a non-carbohydrate based di- or multi-nucleophile crosslinker or diaminotrehalose together with a glycosaminoglycan; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.
A medical device , comprising an implantable element , in particular a heart pump, and a control unit for the implantable element, which is connected to the implantable element by a first connection , characterized in that the control unit is configured for a predetermined orientation outside and relative a patient's body and comprises a radio module , an antenna of the radio module being arranged in such a way that the region in which the position of patient's body is provided, as viewed from the control unit , is shielded at least partially from the antenna by electromagnetically shielding, and in particular electrically conducting, parts of the control unit or the housing thereof.
A spray-dried zirconocene catalyst system comprising a zirconocene catalyst and a hydrophobic fumed silica, which supports the zirconocene catalyst, wherein the zirconocene catalyst of the spray-dried zirconocene catalyst system is made from a reaction of an activator and a zirconocene procatalyst of formula (III): ((R 3 ) z -(4,5,6,7-tetrahydroindenyl))((R 4 ) t -(4,5,6,7-tetrahydroindenyl))zirconium dichloride/dibromide/dialkyl (III), wherein each of subscripts z and t is 1; and wherein a first R 3 is in the 1-position of the 4,5,6,7-tetrahydroindenyl to which it is bonded and a first R 4 is in the 1-position of the 4,5,6,7-tetrahydroindenyl to which it is bonded and the first R 3 is covalently bonded to the first R 4 to form a divalent bridging group of formula Si(R 5 ) 2 , wherein each R 5 is methyl.