mhurhangee/patent-ind-claim-en huggingface dataset:
A fluid treatment system comprising: a sonic energy generator that, in use, applies a sonic signal to at least a portion of a fluid in a vessel ; an electromagnetic field, EMF, generator that, in use, conductively applies an EMF signal to at least the portion of the fluid; a controller that, in use, independently controls the sonic energy generator and the EMF generator ; and a sensor upstream of vessel that, in use, detects at least one of microorganisms and contaminants; wherein the controller is configured to adjust one or more of the sonic signal and EMF signal frequencies, amplitudes, waveforms, phase-shifts, and decay rates in response to readings transmitted by the sensor so as to achieve a correlated signal set that can best impact microorganisms and/or contaminants at the levels detected by the sensor. a sonic energy generator that, in use, applies a sonic signal to at least a portion of a fluid in a vessel ; an electromagnetic field, EMF, generator that, in use, conductively applies an EMF signal to at least the portion of the fluid; a controller that, in use, independently controls the sonic energy generator and the EMF generator ; and a sensor upstream of vessel that, in use, detects at least one of microorganisms and contaminants; wherein the controller is configured to adjust one or more of the sonic signal and EMF signal frequencies, amplitudes, waveforms, phase-shifts, and decay rates in response to readings transmitted by the sensor so as to achieve a correlated signal set that can best impact microorganisms and/or contaminants at the levels detected by the sensor.
A belt for tyres comprising a ply made up of metal cords and two layers of tread ply skim that are arranged to cover the ply; said belt being characterized in that said ply is coated with a protective composition comprising at least one cross-linkable unsaturated-chain polymer base and a surface-active compound; said protective composition being derived from an aqueous-based suspension applied to said ply and subsequently dried; said tread ply skim comprising the same cross-linkable unsaturated-chain polymer base present within said protective composition.
A composition comprising a mesenchymal stem cell (MSC) that (a) is infected with a naturally occurring or genetically modified respiratory syncytial virus (RSV); and (b) is indoleamine 2,3-dioxygenase (IDO) deficient, wherein the MSC is rendered IDO-deficient by gene deletion or gene silencing in the MSC before, during or after infection with the RSV and/or by including an IDO inhibitor in the composition, wherein the IDO inhibitor is selected from a tryptophan analog, a naphthoquinone-based inhibitor, hydroxyamidine, an interfering RNA specific for IDO1 and/or IDO2, NLG919, and combinations thereof.
A composition for use in a method of treating or preventing vasculopathy, comprising administering to a subject in need thereof a composition comprising (i) a culture medium that has been in contact with a mesenchymal stem cell (MSC) and comprises an exosome derived from the MSC, or (ii) an isolated exosome derived from the MSC, wherein the MSC has been exposed to 0.3 μg/mL to 83.3 μg/mL of prostacyclin ex vivo, wherein the MSC is exposed to the prostacyclin for at least 48 hours, and wherein the exposure to the prostacyclin increases the expression of one or more anti-inflammatory factors and/or reduces the expression of one or more pro-inflammatory factors in the MSC, compared to a control MSC not exposed to the prostacyclin, wherein the vasculopathy is a pulmonary hypertension.
A joint structure of a nozzle vane and a lever, comprising: a nozzle vane to be disposed in an exhaust passage for guiding exhaust gas to a turbine wheel of a variable geometry turbocharger , the nozzle vane including a shaft portion ; and a lever including a fitting surface to be fitted with a peripheral surface on one end side of the shaft portion , for transmitting torque to the shaft portion to adjust a vane angle of the nozzle vane , characterized in that the lever and the one end side of the shaft portion are joined to each other by welding performed by adding weld metal , and wherein weld metal at a welded part between the lever and the one end side of the shaft portion is formed so that a center position of the weld metal is disposed inside a position of the fitting surface with respect to a radial direction of the shaft portion . a nozzle vane to be disposed in an exhaust passage for guiding exhaust gas to a turbine wheel of a variable geometry turbocharger , the nozzle vane including a shaft portion ; and a lever including a fitting surface to be fitted with a peripheral surface on one end side of the shaft portion , for transmitting torque to the shaft portion to adjust a vane angle of the nozzle vane , characterized in that the lever and the one end side of the shaft portion are joined to each other by welding performed by adding weld metal , and wherein weld metal at a welded part between the lever and the one end side of the shaft portion is formed so that a center position of the weld metal is disposed inside a position of the fitting surface with respect to a radial direction of the shaft portion .
A tire having a tread at least comprising a first rubber layer constituting a tread surface , a second rubber layer adjacent to inside in a tire radial direction of the first rubber layer, and a third rubber layer adjacent to inside in a tire radial direction of the second rubber layer , wherein a complex elastic modulus of the third rubber layer at 30°C is lower than a complex elastic modulus of the first rubber layer at 30°C and a complex elastic modulus of the second rubber layer at 30°C, wherein a tan δ of the first rubber layer at 30°C is higher than a tan δ of the second rubber layer at 30°C and a tan δ of the third rubber layer at 30°C, wherein the tread has land parts partitioned by a plurality of circumferential grooves extending continuously in a tire circumferential direction, wherein at least one of the land parts has the third layer formed asymmetrically with respect to a normal line (N) passing through the center in the tire width direction (P) in a tire meridian cross section including a tire rotation axis, wherein the thickness of the third rubber layer (t3) is 1.0 mm or more or 10.0 mm or less, and wherein the complex elastic modulus and the tan δ is measured under a condition of a temperature at 30°C, an initial strain of 10%, a dynamic strain of 1%, and a frequency of 10 Hz. wherein a complex elastic modulus of the third rubber layer at 30°C is lower than a complex elastic modulus of the first rubber layer at 30°C and a complex elastic modulus of the second rubber layer at 30°C, wherein a tan δ of the first rubber layer at 30°C is higher than a tan δ of the second rubber layer at 30°C and a tan δ of the third rubber layer at 30°C, wherein the tread has land parts partitioned by a plurality of circumferential grooves extending continuously in a tire circumferential direction, wherein at least one of the land parts has the third layer formed asymmetrically with respect to a normal line (N) passing through the center in the tire width direction (P) in a tire meridian cross section including a tire rotation axis, wherein the thickness of the third rubber layer (t3) is 1.0 mm or more or 10.0 mm or less, and wherein the complex elastic modulus and the tan δ is measured under a condition of a temperature at 30°C, an initial strain of 10%, a dynamic strain of 1%, and a frequency of 10 Hz.
An antenna device, comprising: a ground plane ; a first resonator that extends in a direction away from the ground plane and is connected to a feed point ; and a second resonator disposed at a distance from the first resonator , wherein the first resonator is adapted to resonate and thereby cause the second resonator to function as a radiating conductor; and the second resonator is a line-shaped linear conductor and has a resonance frequency different from a resonance frequency of the first resonator , and the ground plane is formed such that an edge of the ground plane extends along the second resonator and the first and second resonators and the ground plane are adapted to form a resonance current on the first resonator and the ground plane as a result of the interaction between the first resonator and the edge , wherein Le22 indicates an electrical length of the second resonator that imparts a fundamental mode of resonance to the second resonator , and Le22 is greater than or equal to (3/8)· λ and less than or equal to (5/8)· λ, λ being related to the wavelength at the resonant frequency of the fundamental mode of the second resonator , and the fundamental mode of resonance of the second resonator is a dipole mode, and wherein the first resonator is a linear conductor extending in a direction perpendicular to the edge of the ground plane , and the second resonator extends in a direction perpendicular to the direction in which the first resonator extends. a ground plane ; a first resonator that extends in a direction away from the ground plane and is connected to a feed point ; and a second resonator disposed at a distance from the first resonator , wherein the first resonator is adapted to resonate and thereby cause the second resonator to function as a radiating conductor; and the second resonator is a line-shaped linear conductor and has a resonance frequency different from a resonance frequency of the first resonator , and the ground plane is formed such that an edge of the ground plane extends along the second resonator and the first and second resonators and the ground plane are adapted to form a resonance current on the first resonator and the ground plane as a result of the interaction between the first resonator and the edge , wherein Le22 indicates an electrical length of the second resonator that imparts a fundamental mode of resonance to the second resonator , and Le22 is greater than or equal to (3/8)· λ and less than or equal to (5/8)· λ, λ being related to the wavelength at the resonant frequency of the fundamental mode of the second resonator , and the fundamental mode of resonance of the second resonator is a dipole mode, and wherein the first resonator is a linear conductor extending in a direction perpendicular to the edge of the ground plane , and the second resonator extends in a direction perpendicular to the direction in which the first resonator extends.
A control method for a water purifier comprising: Generating purified water by filtering water inflowing through a raw water inlet of a filter unit; Extracting the purified water; Measuring (S300) a flow rate of the purified water extracted per unit time; when the extraction of purified water is completed, flushing the filter unit by supplying the purified water generated by the filter unit to the raw water inlet; and draining (S700) the flushed water externally through a domestic water outlet of the filter unit, wherein the generation of purified water shuts off a discharge of domestic water generated in the generation of purified water, depending on an accumulated flow rate at the time of one-time extraction of the purified water calculated on the basis of a flow rate of the purified water, in the generation of purified water, the discharge of domestic water is shut-off, when the accumulated flow rate is lower than a predetermined amount, in the generation of purified water, the shut-off of domestic water is released to discharge the domestic water, when the accumulated flow rate is equal to or larger than a predetermined amount. Generating purified water by filtering water inflowing through a raw water inlet of a filter unit; Extracting the purified water; Measuring (S300) a flow rate of the purified water extracted per unit time; when the extraction of purified water is completed, flushing the filter unit by supplying the purified water generated by the filter unit to the raw water inlet; and draining (S700) the flushed water externally through a domestic water outlet of the filter unit, wherein the generation of purified water shuts off a discharge of domestic water generated in the generation of purified water, depending on an accumulated flow rate at the time of one-time extraction of the purified water calculated on the basis of a flow rate of the purified water, in the generation of purified water, the discharge of domestic water is shut-off, when the accumulated flow rate is lower than a predetermined amount, in the generation of purified water, the shut-off of domestic water is released to discharge the domestic water, when the accumulated flow rate is equal to or larger than a predetermined amount.
A negative pressure wound therapy system, comprising: a wound dressing configured to form a seal over a wound site of a patient; a vacuum line fluidically connected to a space disposed between the wound dressing and the wound; and a pump system fluidically connected to the vacuum line , characterised in that the pump system further comprises: a housing; a hot heat exchanger configured to receive heat from a heat source thermally connected to the hot heat exchanger; a working fluid thermally coupled to the hot heat exchanger; and a moveable member in contact with the working fluid, the moveable member configured to move when the working fluid expands to thereby generate a negative pressure in the vacuum line to draw a fluid from the wound site; and an elastic member; wherein the moveable member is a swash plate disposed between a hot plate and a cold plate , the hot plate being thermally connected to the hot heat exchanger, the hot and cold plates being comprised in a Stirling engine included in the pump system, the moveable member being configured to compress the elastic member such that the subsequent elastic recovery of the compressed elastic member generates the negative pressure in the vacuum line. a wound dressing configured to form a seal over a wound site of a patient; a vacuum line fluidically connected to a space disposed between the wound dressing and the wound; and a pump system fluidically connected to the vacuum line , characterised in that the pump system further comprises: a housing; a hot heat exchanger configured to receive heat from a heat source thermally connected to the hot heat exchanger; a working fluid thermally coupled to the hot heat exchanger; and a moveable member in contact with the working fluid, the moveable member configured to move when the working fluid expands to thereby generate a negative pressure in the vacuum line to draw a fluid from the wound site; and an elastic member; a housing; a hot heat exchanger configured to receive heat from a heat source thermally connected to the hot heat exchanger; a working fluid thermally coupled to the hot heat exchanger; and a moveable member in contact with the working fluid, the moveable member configured to move when the working fluid expands to thereby generate a negative pressure in the vacuum line to draw a fluid from the wound site; and an elastic member; wherein the moveable member is a swash plate disposed between a hot plate and a cold plate , the hot plate being thermally connected to the hot heat exchanger, the hot and cold plates being comprised in a Stirling engine included in the pump system, the moveable member being configured to compress the elastic member such that the subsequent elastic recovery of the compressed elastic member generates the negative pressure in the vacuum line.
A device for guiding a material web , which device has at least one longitudinal cutting means for adjusting the width of the material web , with which device the web can be separated along its direction of movement (z) into at least one main film web and at least one edge strip , comprising • at least one sensor, with which sensor measured values can be recorded, from which measured values the width of the web can be determined, • at least one actuating device for the at least one longitudinal cutting means , with which actuating device the longitudinal cutting means can be activated and deactivated, which longitudinal cutting means can be controlled on the basis of signals of the at least one sensor, characterized by at least one transverse cutting device for the severing of an edge strip , which transverse cutting device can be activated by a control device, wherein the transverse cutting device is mounted further downstream than the longitudinal cutting means and wherein the control device is configured to calculate the time difference in which the cutter of the transverse cutting device must enter the material web, in order to carry out the transverse cut, when the beginning of a longitudinal cut has arrived at the transverse cut location. • at least one sensor, with which sensor measured values can be recorded, from which measured values the width of the web can be determined, • at least one actuating device for the at least one longitudinal cutting means , with which actuating device the longitudinal cutting means can be activated and deactivated,
A wearable device , comprising: a first anchor configured for positioning on an upper body of a person wearing the wearable device; a second anchor configured for positioning on a first leg of the person wearing the wearable device; a third anchor configured for positioning on a second leg of the person wearing the wearable device; at least one actuator coupling the first anchor to the second anchor, wherein actuation of the at least one actuator generates a tensile force in the wearable device for generating a moment about one or more joints of the person; and characterised in that the wearable device further comprises a load balancing assembly coupling the at least one actuator to the second anchor and the third anchor, the load balancing assembly comprising a flexible elongate member having a first end coupled to the second anchor and a second end connected to the third anchor, and a mechanism coupling the at least one actuator to an intermediate portion of the flexible elongate member between the first end and the second end, and configured to allow the flexible elongate member to translate within the mechanism and thereby balance the tensile force distributed to the first leg and the second leg of the wearer. a first anchor configured for positioning on an upper body of a person wearing the wearable device; a second anchor configured for positioning on a first leg of the person wearing the wearable device; a third anchor configured for positioning on a second leg of the person wearing the wearable device; at least one actuator coupling the first anchor to the second anchor, wherein actuation of the at least one actuator generates a tensile force in the wearable device for generating a moment about one or more joints of the person; and characterised in that the wearable device further comprises a load balancing assembly coupling the at least one actuator to the second anchor and the third anchor, the load balancing assembly comprising a flexible elongate member having a first end coupled to the second anchor and a second end connected to the third anchor, and a mechanism coupling the at least one actuator to an intermediate portion of the flexible elongate member between the first end and the second end, and configured to allow the flexible elongate member to translate within the mechanism and thereby balance the tensile force distributed to the first leg and the second leg of the wearer.
A spherical sector viewport window sealing ring replacing device, wherein the sealing ring replacing device is used to replace a sealing ring mounted in a sealing groove formed by a spherical sector viewport window , wherein the spherical sector viewport window is mounted on a window seat , the window seat being mounted on a flange ,through a plurality of O-rings , wherein a pressure ring is mounted on a circumferential surface of the joint of the spherical sector viewport window and the window seat through a pressure ring rubber pad and a sealing device, and at the same time, the pressure ring is locked with the window seat through hexagon socket bolts ; the sealing ring replacing device comprising a plurality of replacement tools to be mounted at intervals in a circumferential direction of the window seat ; wherein a single replacement tool structurally comprises a support , a right-angle frame is extended upward at the rear end of the support , one of the right-angle sides of the right-angle frame is provided with a through hole , a long bolt is mounted at the through hole and is connected with the window seat and the flange and locked through a first nut , a mounting sleeve is extended downward at the bottom of the front end of the support , a screw rod is mounted in the mounting sleeve and fixed through a second nut , a pressure plate is fixed at the bottom of the screw rod , and the bottom surface of the pressure plate abuts against the spherical sector viewport window through a tool rubber pad . wherein a pressure ring is mounted on a circumferential surface of the joint of the spherical sector viewport window and the window seat through a pressure ring rubber pad and a sealing device, and at the same time, the pressure ring is locked with the window seat through hexagon socket bolts ; the sealing ring replacing device comprising a plurality of replacement tools to be mounted at intervals in a circumferential direction of the window seat ; wherein a single replacement tool structurally comprises a support , a right-angle frame is extended upward at the rear end of the support , one of the right-angle sides of the right-angle frame is provided with a through hole , a long bolt is mounted at the through hole and is connected with the window seat and the flange and locked through a first nut , a mounting sleeve is extended downward at the bottom of the front end of the support , a screw rod is mounted in the mounting sleeve and fixed through a second nut , a pressure plate is fixed at the bottom of the screw rod , and the bottom surface of the pressure plate abuts against the spherical sector viewport window through a tool rubber pad .
An antisense oligonucleotide fully complementary over the entirety of said oligonucleotide to a nucleic acid encoding human α4 integrin, in combination with one or more chemo-therapeutic or immune-oncolytic agents for use in a method of treating acute myeloid leukemia (AML) in a human subject, the method comprising the step of administering to the human subject an amount of said antisense oligonucleotide wherein the oligonucleotide consists of a 2' deoxynucleotide region flanked on both 5' and 3' ends with one or more 2'-O-(2-methoxyethyl) modified ribonucleotides, one or more phosphorothioates, and one or more 5-methylcytosines and wherein the antisense oligonucleotide consists of the nucleobase sequence of SEQ ID NO: 1, and wherein the antisense oligonucleotide is: 5'- Me C Me UG AGT Me CTG TTT Me U Me C Me C A Me U Me U Me C Me U-3' wherein, a) each of the 19 internucleotide linkages of the oligonucleotide is an O,O-linked phosphorothioate diester; b) the nucleotides at the positions 1 to 3 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; c) the nucleotides at the positions 4 to 12 from the 5' end are 2'-deoxyribonucleosides; d) the nucleotides at the positions 13 to 20 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; and e) all cytosines are 5-methylcytosines ( Me C), or a pharmaceutically acceptable salt thereof. a) each of the 19 internucleotide linkages of the oligonucleotide is an O,O-linked phosphorothioate diester; b) the nucleotides at the positions 1 to 3 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; c) the nucleotides at the positions 4 to 12 from the 5' end are 2'-deoxyribonucleosides; d) the nucleotides at the positions 13 to 20 from the 5' end are 2'-O-(2-methoxyethyl) modified ribonucleosides; and e) all cytosines are 5-methylcytosines ( Me C),