A polymeric nanocapsule which comprises: a. A polymeric shell; and b. one or more metal and/or serine proteases encapsulated or embedded in the polymeric shell, wherein the polymeric shell of a) comprises: - at least two structural monomers of formula I: wherein in the first structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is NH, and R4 is -H; wherein in the second structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is O, and -R 4 is a C 1 to C 4 -alkyl-NH2; and - at least one degradable and at least one non-degradable cross-linker of Formula II: wherein in the degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is O; and wherein in the non-degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is NH; and wherein the protease:monomer ratio and the molar ratio between the first structural monomer/second structural monomer/degradable cross-linker/non-degradable cross-linker are, respectively, 1:2420 and 7:6:1:1. a. A polymeric shell; and b. one or more metal and/or serine proteases encapsulated or embedded in the polymeric shell, wherein the polymeric shell of a) comprises: - at least two structural monomers of formula I: wherein in the first structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is NH, and R4 is -H; wherein in the second structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is O, and -R 4 is a C 1 to C 4 -alkyl-NH2; and - at least one degradable and at least one non-degradable cross-linker of Formula II: wherein in the degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is O; and wherein in the non-degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is NH; and wherein the protease:monomer ratio and the molar ratio between the first structural monomer/second structural monomer/degradable cross-linker/non-degradable cross-linker are, respectively, 1:2420 and 7:6:1:1. - at least two structural monomers of formula I: wherein in the first structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is NH, and R4 is -H; wherein in the second structural monomer R 1 , R 2 , and R 3 , are hydrogen or C 1 to C 4 alkyl groups, X is O, and -R 4 is a C 1 to C 4 -alkyl-NH2; and - at least one degradable and at least one non-degradable cross-linker of Formula II: wherein in the degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is O; and wherein in the non-degradable cross-linker R 1 , R 2 , R 3 , R 5 , R 6 and R 7 a are hydrogen or C 1 to C 4 alkyl groups, R 4 is a C 1 to C 4 alkyl group, and X (5' and 6') is NH; and wherein the protease:monomer ratio and the molar ratio between the first structural monomer/second structural monomer/degradable cross-linker/non-degradable cross-linker are, respectively, 1:2420 and 7:6:1:1. <EOS>