mhurhangee/patent-ind-claim-en huggingface dataset:
A recombinant adeno-associated virus (rAAV) for use in a method for the treatment of wet age-related macular degeneration (wet AMD) in a human subject having wet AMD, the method comprising: i) administering at least one dose of a Vascular Endothelial Growth Factor (VEGF) inhibitor selected from an anti-VEGF antibody and a soluble VEGF receptor, or a fusion protein or fragment thereof, by intravitreal injection between 1 to 30 days prior to administering the rAAV to the human subject; ii) injecting into the eye of the human subject a unit dose comprising at least 1 x 10 6 and at most 1 x 10 15 vector genomes of the rAAV and a pharmaceutically acceptable carrier, wherein the rAAV comprises a nucleic acid sequence encoding an anti-VEGF protein, and wherein the anti-VEGF protein comprises human sFLT1 or a functional fragment thereof; and optionally iii) administering one or two doses of the VEGF inhibitor of i) by intraocular injection in a 30 day interval following administration of the rAAV. i) administering at least one dose of a Vascular Endothelial Growth Factor (VEGF) inhibitor selected from an anti-VEGF antibody and a soluble VEGF receptor, or a fusion protein or fragment thereof, by intravitreal injection between 1 to 30 days prior to administering the rAAV to the human subject; ii) injecting into the eye of the human subject a unit dose comprising at least 1 x 10 6 and at most 1 x 10 15 vector genomes of the rAAV and a pharmaceutically acceptable carrier, wherein the rAAV comprises a nucleic acid sequence encoding an anti-VEGF protein, and wherein the anti-VEGF protein comprises human sFLT1 or a functional fragment thereof; and optionally iii) administering one or two doses of the VEGF inhibitor of i) by intraocular injection in a 30 day interval following administration of the rAAV.
A method for producing a solid material from a saccharide liquid comprising isomaltulose, wherein said saccharide liquid is obtained by allowing an alpha-glucosyltransferase to act on a sucrose liquid, wherein said method comprises steps: - heating said saccharide liquid to adjust a solid content of said saccharide liquid to 77 to 96 mass%, - subjecting a mixture resulting from the aforesaid step to a shearing force to generate crystal nuclei, while keeping a temperature of the product at 65 to 120 degrees Celsius, and - cooling the mixture to obtain the solid material, - wherein the solid material comprises isomaltulose of an amount of 70 to 90 mass% and trehalulose of an amount of 8 to 25 mass%, and is an aggregate of isomaltulose crystals and non-crystalline saccharide liquid which comprises trehalulose. - heating said saccharide liquid to adjust a solid content of said saccharide liquid to 77 to 96 mass%, - subjecting a mixture resulting from the aforesaid step to a shearing force to generate crystal nuclei, while keeping a temperature of the product at 65 to 120 degrees Celsius, and - cooling the mixture to obtain the solid material, - wherein the solid material comprises isomaltulose of an amount of 70 to 90 mass% and trehalulose of an amount of 8 to 25 mass%, and is an aggregate of isomaltulose crystals and non-crystalline saccharide liquid which comprises trehalulose.
A method of characterizing a disease or disorder, comprising: (a) contacting a biological test sample with a plurality of oligonucleotides, wherein the plurality of oligonucleotides comprises 164 different oligonucleotide sequences, and wherein each different member of the plurality of oligonucleotides comprises a different sequence that is any one of SEQ ID NOs. 510599-510763 or a sequence that is 95 percent homologous to any one of SEQ ID NOs. 510599-510763; (b) detecting a presence or level of complexes formed in step (a) between the plurality of oligonucleotides and a target in the biological test sample; and (c) comparing the presence or level detected in step (b) to a reference level from a biological control sample, thereby characterizing the disease or disorder. (a) contacting a biological test sample with a plurality of oligonucleotides, wherein the plurality of oligonucleotides comprises 164 different oligonucleotide sequences, and wherein each different member of the plurality of oligonucleotides comprises a different sequence that is any one of SEQ ID NOs. 510599-510763 or a sequence that is 95 percent homologous to any one of SEQ ID NOs. 510599-510763; (b) detecting a presence or level of complexes formed in step (a) between the plurality of oligonucleotides and a target in the biological test sample; and (c) comparing the presence or level detected in step (b) to a reference level from a biological control sample, thereby characterizing the disease or disorder.
A hinge, adapted to be installed between a door leaf and a door frame or between a sash and a window frame , comprising a first support bar adapted to be installed on the door or window frame , a gear and rack unit, an inclined draw bar and a second support bar adapted to be installed on the door leaf or sash , wherein two ends of the inclined draw bar are respectively rotatably connected with the first support bar and the second support bar by means of an axis of rotation , the gear and rack unit is provided on the first support bar and comprises a gear and a rack located on one side of the gear and meshed with the gear , wherein the rack is fixed on the first support bar , characterized in that , the first support bar is provided with a gear installation groove , the gear is rotatably and horizontally movably provided on the first support bar by means of a gear installation shaft which is horizontally movably received within the gear installation groove , and the gear is provided with a gear installation portion on one side thereof, the hinge further comprises an installation shaft , the gear installation portion is connected with the second support bar by means of the installation shaft , and a hinge element is arranged on the installation shaft , one side of the door leaf or sash is adapted to be installed, in use, on the hinge element , and the door leaf or sash is rotatable about the installation shaft . two ends of the inclined draw bar are respectively rotatably connected with the first support bar and the second support bar by means of an axis of rotation , the gear and rack unit is provided on the first support bar and comprises a gear and a rack located on one side of the gear and meshed with the gear , wherein the rack is fixed on the first support bar , characterized in that , the first support bar is provided with a gear installation groove , the gear is rotatably and horizontally movably provided on the first support bar by means of a gear installation shaft which is horizontally movably received within the gear installation groove , and the gear is provided with a gear installation portion on one side thereof, the hinge further comprises an installation shaft , the gear installation portion is connected with the second support bar by means of the installation shaft , and a hinge element is arranged on the installation shaft , one side of the door leaf or sash is adapted to be installed, in use, on the hinge element , and the door leaf or sash is rotatable about the installation shaft .
A method for processing packets using a network functions virtualization, NFV, backplane within a network device, the method comprising: configuring the NFV backplane within the network device by establishing, by processing circuitry of a forwarding microchip of the network device, a respective logical connection between each of a plurality of virtual ports of the forwarding microchip and each of a plurality of virtual ports , configured for respective software-implemented virtual network functions, VNFs, executing on the network device, wherein establishing the respective logical connection comprises assigning, by the processing circuitry, a Virtual Local Area Network , VLAN, identifier to pairs of the plurality of virtual ports of the forwarding microchip and the plurality of virtual ports configured for the respective software-implemented VNFs; receiving, by the processing circuitry, a packet via one or more physical ports of the forwarding microchip; processing, by the processing circuitry, the packet to identify a virtual port of the forwarding microchip corresponding to the packet; adding, by the processing circuitry, an outer VLAN tag to the packet corresponding to the identified virtual port; and forwarding, by the processing circuitry and via the identified virtual port of the forwarding microchip, the packet to a Network Interface Controller, NIC, of the network device for forwarding to the virtual port configured for the respective software-implemented VNFs corresponding to the same VLAN identifier as the identified virtual port of the forwarding microchip. configuring the NFV backplane within the network device by establishing, by processing circuitry of a forwarding microchip of the network device, a respective logical connection between each of a plurality of virtual ports of the forwarding microchip and each of a plurality of virtual ports , configured for respective software-implemented virtual network functions, VNFs, executing on the network device, wherein establishing the respective logical connection comprises assigning, by the processing circuitry, a Virtual Local Area Network , VLAN, identifier to pairs of the plurality of virtual ports of the forwarding microchip and the plurality of virtual ports configured for the respective software-implemented VNFs; receiving, by the processing circuitry, a packet via one or more physical ports of the forwarding microchip; processing, by the processing circuitry, the packet to identify a virtual port of the forwarding microchip corresponding to the packet; adding, by the processing circuitry, an outer VLAN tag to the packet corresponding to the identified virtual port; and forwarding, by the processing circuitry and via the identified virtual port of the forwarding microchip, the packet to a Network Interface Controller, NIC, of the network device for forwarding to the virtual port configured for the respective software-implemented VNFs corresponding to the same VLAN identifier as the identified virtual port of the forwarding microchip.
An internal combustion engine in which an anodic oxide film is formed on part or all of an aluminum-based wall surface (B) facing a combustion chamber, characterized in that : an aluminum-based material that forms the aluminum-based wall surface contains Si and Cu as an alloy component, a content of Si in the aluminum-based material is higher than or equal to 5 % and less than 20 % and a content of Cu in the aluminum-based material is higher than or equal to 0.4 % and less than 7 %, the anodic oxide film has a thickness of 30 μm to 170 μm; the anodic oxide film has first micropores having a micro-size diameter, nanopores having a nano-size diameter and second micropores having a micro-size diameter, the first micropores and second micropores have a sectional diameter or maximum size of a range of 1 to 100 μm and the nanopores have a sectional diameter or maximum size of a range of 10 to 100 nm, the first micropores and the nanopores extending from a surface of the anodic oxide film toward an inside of the anodic oxide film in a thickness direction of the anodic oxide film or substantially the thickness direction, the second micropores being provided inside the anodic oxide film; at least part of the first micropores and the nanopores are sealed with a seal that is converted from a sealant; at least part of the second micropores are not sealed; and the anodic oxide film sealed with the seal has a porosity of 20 to 70 %. an aluminum-based material that forms the aluminum-based wall surface contains Si and Cu as an alloy component, a content of Si in the aluminum-based material is higher than or equal to 5 % and less than 20 % and a content of Cu in the aluminum-based material is higher than or equal to 0.4 % and less than 7 %, the anodic oxide film has a thickness of 30 μm to 170 μm; the anodic oxide film has first micropores having a micro-size diameter, nanopores having a nano-size diameter and second micropores having a micro-size diameter, the first micropores and second micropores have a sectional diameter or maximum size of a range of 1 to 100 μm and the nanopores have a sectional diameter or maximum size of a range of 10 to 100 nm, the first micropores and the nanopores extending from a surface of the anodic oxide film toward an inside of the anodic oxide film in a thickness direction of the anodic oxide film or substantially the thickness direction, the second micropores being provided inside the anodic oxide film; at least part of the first micropores and the nanopores are sealed with a seal that is converted from a sealant; at least part of the second micropores are not sealed; and the anodic oxide film sealed with the seal has a porosity of 20 to 70 %.
An isolated multispecific antibody consisting of (i) a first antigen-binding polypeptide, wherein the first antigen-binding polypeptide comprises a VL domain, a linker, a VH domain, a CH1 domain, a CH2 domain and a CH3 domain positioned in an N-terminal to C-terminal direction in the following sequence VL-linker-VH-CH1-CH2-CH3; (ii) a second antigen-binding polypeptide, wherein the second antigen-binding polypeptide comprises a VL domain, a linker, a VH domain, a CH1 domain, a CH2 domain and a CH3 domain positioned in an N-terminal to C-terminal direction in the following sequence VL-linker-VH-CH1-CH2-CH3; and (iii) two identical CL domains, wherein one of the two CL domains is linked to the CH1 domain of the first antigen-binding polypeptide by one or more disulfide bridges, and the second of the two CL domains is linked to the CH1 domain of the second antigen-binding polypeptide by one or more disulfide bridges; wherein the first and second antigen-binding polypeptides bind two different antigens, or the first and second antigen-binding polypeptides bind to two different epitopes of the same antigen. (i) a first antigen-binding polypeptide, wherein the first antigen-binding polypeptide comprises a VL domain, a linker, a VH domain, a CH1 domain, a CH2 domain and a CH3 domain positioned in an N-terminal to C-terminal direction in the following sequence VL-linker-VH-CH1-CH2-CH3; (ii) a second antigen-binding polypeptide, wherein the second antigen-binding polypeptide comprises a VL domain, a linker, a VH domain, a CH1 domain, a CH2 domain and a CH3 domain positioned in an N-terminal to C-terminal direction in the following sequence VL-linker-VH-CH1-CH2-CH3; and (iii) two identical CL domains, wherein one of the two CL domains is linked to the CH1 domain of the first antigen-binding polypeptide by one or more disulfide bridges, and the second of the two CL domains is linked to the CH1 domain of the second antigen-binding polypeptide by one or more disulfide bridges;
A method for detecting microscopic objects of foreign origin present in a fluid by utilizing first, second, and third image data originating from first, second, and third digital image frames, respectively, captured sequentially in time by an image sensor receiving light propagated across a sample volume containing a fluid possibly comprising moving microscopic objects of foreign origin while illuminating the sample volume by coherent light, whereby the possible microscopic objects scatter part of the light, the scattered and non-scattered light interfering so as to form interference fringes behind the microscopic objects, each image data comprising, for a moving microscopic object of foreign origin present in the sample volume at the time of capture of the associated digital image frame, a hologram pattern with spatially alternating intensity formed by the interference fringes , the method comprising: obtaining first differential image data comprising the difference of the first and the second image data, the first differential image data comprising, for each hologram pattern present in the first or second image data, a differential pattern ; obtaining second differential image data comprising the difference of the second and the third image data, the second differential image data comprising, for each hologram pattern present in the second or third image data, a differential pattern ; automatically generating product of difference (POD) image data comprising the product of the first and the second differential image data, the POD image data comprising, for each hologram pattern present in the second image data, a product pattern ; and automatically detecting the presence of moving microscopic object(s) of foreign origin in the sample volume on the basis of product pattern(s) present in the POD image data . obtaining first differential image data comprising the difference of the first and the second image data, the first differential image data comprising, for each hologram pattern present in the first or second image data, a differential pattern ; obtaining second differential image data comprising the difference of the second and the third image data, the second differential image data comprising, for each hologram pattern present in the second or third image data, a differential pattern ; automatically generating product of difference (POD) image data comprising the product of the first and the second differential image data, the POD image data comprising, for each hologram pattern present in the second image data, a product pattern ; and automatically detecting the presence of moving microscopic object(s) of foreign origin in the sample volume on the basis of product pattern(s) present in the POD image data .
An indoor unit of an air-conditioning apparatus comprising: a frame body as a framework; side panels mounted respectively on both side surfaces of the frame body ; a front opening-and-closing panel mounted in the front of the frame body so as to be openable and closable; L-shaped panels mounted respectively near the side panels so as to straddle a lower area of the front of the frame body below the front opening-and-closing panel and a front-side area of a bottom surface ; and a bottom panel mounted between the L-shaped panels on the bottom surface of the frame body ; wherein the front opening-and-closing panel includes a panel frame body having a substantially flat surface of a rectangular shape and a panel design surface attached to the panel frame body ; characterized in that the frame body is a parallelepiped, the side panels , the panel design surface , and the bottom panel are each formed of a rectangular single flat surface, and each of the L-shaped panels is formed of a pair of rectangular flat surfaces orthogonal to each other. a frame body as a framework; side panels mounted respectively on both side surfaces of the frame body ; a front opening-and-closing panel mounted in the front of the frame body so as to be openable and closable; L-shaped panels mounted respectively near the side panels so as to straddle a lower area of the front of the frame body below the front opening-and-closing panel and a front-side area of a bottom surface ; and a bottom panel mounted between the L-shaped panels on the bottom surface of the frame body ; wherein the front opening-and-closing panel includes a panel frame body having a substantially flat surface of a rectangular shape and a panel design surface attached to the panel frame body ; characterized in that the frame body is a parallelepiped, the side panels , the panel design surface , and the bottom panel are each formed of a rectangular single flat surface, and each of the L-shaped panels is formed of a pair of rectangular flat surfaces orthogonal to each other.
A method for performing an operation in response to a read request, the method comprising by a first computing device : receiving a request to read a value , wherein the request is received from a second computing device via a wireless communication link between the first computing device and the second computing device; determining an operation corresponding to the value, wherein each of a plurality of readable values corresponds to a different respective operation; and performing the operation corresponding to the value in response to the request and returning the value to the second computing device in response to the request. receiving a request to read a value , wherein the request is received from a second computing device via a wireless communication link between the first computing device and the second computing device; determining an operation corresponding to the value, wherein each of a plurality of readable values corresponds to a different respective operation; and performing the operation corresponding to the value in response to the request and returning the value to the second computing device in response to the request.
An imaging system for generating a display including an intravascular device overlayed on a vessel roadmap , the imaging system comprising: a data receiver configured to receive live fluoroscopic imaging including an intravascular device ; an image processing system configured to: receive a vessel roadmap ; and generate a display including the vessel roadmap and the intravascular device overlayed on the vessel roadmap based on the live fluoroscopic imaging; determine panning data representing a selected region of the vessel roadmap that is panned to match panning of the field of view of the live fluoroscopic images, wherein the panning data is based on a comparison between biological reference markers in the vessel roadmap and the live fluoroscopic imaging; and pan the display of the vessel roadmap based on the panning data corresponding to panning of a field of view of the live fluoroscopic imaging so that the intravascular device is overlayed at a correct location on the vessel roadmap. a data receiver configured to receive live fluoroscopic imaging including an intravascular device ; an image processing system configured to: receive a vessel roadmap ; and generate a display including the vessel roadmap and the intravascular device overlayed on the vessel roadmap based on the live fluoroscopic imaging; determine panning data representing a selected region of the vessel roadmap that is panned to match panning of the field of view of the live fluoroscopic images, wherein the panning data is based on a comparison between biological reference markers in the vessel roadmap and the live fluoroscopic imaging; and pan the display of the vessel roadmap based on the panning data corresponding to panning of a field of view of the live fluoroscopic imaging so that the intravascular device is overlayed at a correct location on the vessel roadmap. receive a vessel roadmap ; and generate a display including the vessel roadmap and the intravascular device overlayed on the vessel roadmap based on the live fluoroscopic imaging; determine panning data representing a selected region of the vessel roadmap that is panned to match panning of the field of view of the live fluoroscopic images, wherein the panning data is based on a comparison between biological reference markers in the vessel roadmap and the live fluoroscopic imaging; and pan the display of the vessel roadmap based on the panning data corresponding to panning of a field of view of the live fluoroscopic imaging so that the intravascular device is overlayed at a correct location on the vessel roadmap.