A medical device system, comprising: at least one kinetic sensor , each said sensor configured to collect at least one kinetic signal from a patient; an activity level module configured to determine an activity level of said patient, based at least in part on said at least one kinetic signal; at least one sensor configured to sense a body signal; a body index determination module configured to determine a first body index based on a first sensed body signal and a second body index based on a second sensed body signal; a body index range module , configured to determine a first non-pathological body index range for said first body index and a second non-pathological body index range for said second body index, based at least in part on said activity level; a pathological state determination module , configured to determine that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the first body index is within said first non-pathological body index range and the second body index is within said second non-pathological body index range, and said patient is determined to be in a pathological state if the first body index is outside said first non-pathological body index range and the second body index is outside said second non-pathological body index range; and an additional factor module configured to determine one or more of a time of day and an indicator of a patient's level of consciousness and provide an output relating to said determination; and wherein the body index range module is configured to dynamically adjust the non-pathological body index range based on the determined activity level; and the body index range module is further configured to determine the first non-pathological body index range for the first body index and the second non-pathological body index range for the second body index based at least in part on said output of said additional factor module . at least one kinetic sensor , each said sensor configured to collect at least one kinetic signal from a patient; an activity level module configured to determine an activity level of said patient, based at least in part on said at least one kinetic signal; at least one sensor configured to sense a body signal; a body index determination module configured to determine a first body index based on a first sensed body signal and a second body index based on a second sensed body signal; a body index range module , configured to determine a first non-pathological body index range for said first body index and a second non-pathological body index range for said second body index, based at least in part on said activity level; a pathological state determination module , configured to determine that the patient is in one of a non-pathological state and a pathological state, wherein said patient is determined to be in a non-pathological state if the first body index is within said first non-pathological body index range and the second body index is within said second non-pathological body index range, and said patient is determined to be in a pathological state if the first body index is outside said first non-pathological body index range and the second body index is outside said second non-pathological body index range; and an additional factor module configured to determine one or more of a time of day and an indicator of a patient's level of consciousness and provide an output relating to said determination; and wherein the body index range module is configured to dynamically adjust the non-pathological body index range based on the determined activity level; and the body index range module is further configured to determine the first non-pathological body index range for the first body index and the second non-pathological body index range for the second body index based at least in part on said output of said additional factor module . <EOS>