mhurhangee/patent-ind-claim-en huggingface dataset:
A recombinant replication-competent gamma retroviral vector comprising: a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a pAC3-based retroviral polynucleotide comprising: Long-Terminal Repeat (LTR) sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and cis-acting sequences necessary for reverse transcription, packaging and integration in a target cell, wherein the inhibitory nucleic acid sequence down regulate an immune inhibitory agent selected from PD-L1, IDO-1, and TGF-β 2 and wherein the LTR sequences, the promoter sequence, the gag nucleic acid domain, the pol nucleic acid domain, the env nucleic acid domain, and cis-acting sequences are retroviral sequences of corresponding pAC3 DNA sequences presented in SEQ ID NO:1 and 7-16. a retroviral GAG protein; a retroviral POL protein; a retroviral envelope; a pAC3-based retroviral polynucleotide comprising: Long-Terminal Repeat (LTR) sequences at the 3' end of the retroviral polynucleotide sequence, a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and a promoter sequence at the 5' end of the retroviral polynucleotide, said promoter being suitable for expression in a mammalian cell, a gag nucleic acid domain, a pol nucleic acid domain; and an env nucleic acid domain; at least one expression cassette comprising a heterologous nucleic acid sequence, wherein the cassette is positioned 5' to the 3' LTR and 3' to the env nucleic acid domain encoding the retroviral envelope, and wherein the heterologous nucleic acid encodes an inhibitory nucleic acid sequence incorporated into miR30shRNA; and cis-acting sequences necessary for reverse transcription, packaging and integration in a target cell, wherein the inhibitory nucleic acid sequence down regulate an immune inhibitory agent selected from PD-L1, IDO-1, and TGF-β 2 and wherein the LTR sequences, the promoter sequence, the gag nucleic acid domain, the pol nucleic acid domain, the env nucleic acid domain, and cis-acting sequences are retroviral sequences of corresponding pAC3 DNA sequences presented in SEQ ID NO:1 and 7-16.
A tire tread having circumferential grooves , the tread further comprising a tread cap comprising a first rubber compound for contacting a road when driving, at least one circumferential groove reinforcement forming at least one of the grooves in the tread cap , the groove reinforcement comprising a second rubber compound for reinforcing an area adjacent the grooves formed by the groove reinforcement , wherein the groove reinforcement comprises for at least one of the grooves formed by the groove reinforcement : two groove sidewall layers , each sidewall layer extending from the radially outer surface of the unworn tread down into the direction of the bottom of the groove formed by the groove reinforcement and wherein each sidewall layer has an essentially uniform thickness (d p ) along its length, and a groove support portion forming a bottom portion of the groove and having a radially inner base side as well as a radially outer top side , wherein the groove support portion tapers from its base side to its top side , and wherein the tread further comprises a tread base layer arranged radially inwards of the tread cap , the tread base layer comprising a third rubber compound, wherein the groove reinforcement extends in a radially inner direction at least onto the radially outer surface of the base layer , characterized in that the base side of the groove support portion is from 1.1 to 5 times longer than the axial width of the bottom of the reinforced groove. two groove sidewall layers , each sidewall layer extending from the radially outer surface of the unworn tread down into the direction of the bottom of the groove formed by the groove reinforcement and wherein each sidewall layer has an essentially uniform thickness (d p ) along its length, and a groove support portion forming a bottom portion of the groove and having a radially inner base side as well as a radially outer top side , wherein the groove support portion tapers from its base side to its top side , and wherein the tread further comprises a tread base layer arranged radially inwards of the tread cap , the tread base layer comprising a third rubber compound, wherein the groove reinforcement extends in a radially inner direction at least onto the radially outer surface of the base layer , characterized in that the base side of the groove support portion is from 1.1 to 5 times longer than the axial width of the bottom of the reinforced groove.
Device having a form punch for riveting a first part to a second part , in particular a mating partner, wherein the first part is able to be assigned a heated connecting element which serves for connecting the first part to the second part , and having a barrel in which the form punch is movably mounted, and wherein an internal diameter of the barrel corresponds to a diameter of the connecting element deformed by the form punch , characterized in that the form punch is connected to a pneumatic unit by way of which the form punch is able to be impinged with a controllable and variable, in particular continuous, pressure, wherein the pressure is preferably variable as a function of a temperature of the connecting element , and wherein a duration of the impingement of the connecting element with pressure is preferably adjustable or variable by way of the pneumatic unit.
Method for controlling a driving dynamics function of a working machine with at least two vehicle axles (I, II, III), wherein a current wheel speed of at least one wheel (R1, R1', R2, R2', R3, R3') is detected and is fed to a control device for a comparison with a permissible wheel speed of the same wheel (R1, R1', R2, R2', R3, R3') and a wheel slip is calculated from it, wherein a control signal for blocking at least one differential gear mechanism is output by the control device if the wheel slip assumes an impermissible value, wherein a control signal for unblocking is output and a renewed comparison of the wheel speeds is performed periodically for the relevant differential gear mechanism , wherein a control signal for blocking the relevant differential gear mechanism is output once more if the wheel slip continues to assume an impermissible value, characterized in that a route along which the value of the wheel slip of the at least one wheel (R1, R1', R2, R2', R3, R3') had an impermissible value is detected by using detection means (S1, S1', S2, S2', S3, S3').
A compound of Formula (IB): an ester of the compound of Formula (IB), or a pharmaceutically acceptable salt of each of the foregoing, for use in a method of treating a patient diagnosed with idiopathic pulmonary fibrosis (IPF).
A kit for laying a table on a rest surface, the kit comprising at least an item of cutlery and a placemat which has a first face and a second face , opposite the first face , for contacting a rest surface in a use condition and which is folded to accommodate the at least an item of cutlery in a condition of conservation, wherein: - the placemat is folded in one or more folds and has only the second face thereof facing, at least partially, towards the outside, the folded placemat forming layers of placemat ; - the folded placemat comprises a first closure and a second closure , both openable; - at least a first fold of the one or more folds , the first closure and the second closure retain the at least an item of cutlery between layers of placemat ; - the unfolding of the folded placemat causes the opening of the first closure and the second closure ; - both the first closure and the second closure comprise partial perforations of superposed layers of placemat , each partial perforation being folded together with a corresponding partial perforation of each of the remaining superposed layers of placemat ; - the folded placemat has a first side that is open to enable access between two layers of placemat ; characterized in that the first closure and the second closure are opposite one another with respect to the first fold and with respect to the first side . - the placemat is folded in one or more folds and has only the second face thereof facing, at least partially, towards the outside, the folded placemat forming layers of placemat ; - the folded placemat comprises a first closure and a second closure , both openable; - at least a first fold of the one or more folds , the first closure and the second closure retain the at least an item of cutlery between layers of placemat ; - the unfolding of the folded placemat causes the opening of the first closure and the second closure ; - both the first closure and the second closure comprise partial perforations of superposed layers of placemat , each partial perforation being folded together with a corresponding partial perforation of each of the remaining superposed layers of placemat ; - the folded placemat has a first side that is open to enable access between two layers of placemat ;
A fuel cell sub-assembly comprising; a gasket comprising a peripheral seal for a fuel cell assembly, the peripheral seal defining a central aperture of the gasket; a gas diffusion layer for providing diffused gases to a proton exchange membrane of a fuel cell, the gas diffusion layer located within the central aperture; wherein at at least one connection point , an inside facing surface of the peripheral seal of the gasket is welded to a corresponding outward facing surface of the gas diffusion layer, wherein the gas diffusion layer, except at the or each connection point , is uniformly spaced by a predetermined spacing from the inside-facing surface of the gasket for forming a gallery. a gasket comprising a peripheral seal for a fuel cell assembly, the peripheral seal defining a central aperture of the gasket; a gas diffusion layer for providing diffused gases to a proton exchange membrane of a fuel cell, the gas diffusion layer located within the central aperture; wherein at at least one connection point , an inside facing surface of the peripheral seal of the gasket is welded to a corresponding outward facing surface of the gas diffusion layer, wherein the gas diffusion layer, except at the or each connection point , is uniformly spaced by a predetermined spacing from the inside-facing surface of the gasket for forming a gallery.
A method of measuring lung motion in a patient including the steps of: monitoring a parameter corresponding to motion of the lung, and acquiring multiple in vivo fluoroscopy images of the lung, the timing of image acquisition of the multiple in vivo fluoroscopy images being correlated with a change in the value of the parameter, wherein data of lung motion between two or more of the acquired fluoroscopy images is measured. monitoring a parameter corresponding to motion of the lung, and acquiring multiple in vivo fluoroscopy images of the lung, the timing of image acquisition of the multiple in vivo fluoroscopy images being correlated with a change in the value of the parameter, wherein data of lung motion between two or more of the acquired fluoroscopy images is measured.
A method performed by a user equipment configured for use in a wireless communication system, the method comprising: detecting an orientation of an equipment coordinate frame defined for the user equipment relative to an earth coordinate frame defined for Earth; determining , based on the detected orientation, a set of beams defined in the equipment coordinate frame which does not include any beam pointing in one or more predefined directions in the earth coordinate frame ; and performing a beam sweep or scan on the determined set of beams; characterized by : J further comprising deciding whether the set of beams is to not include any beam pointing in at least one of the one or more predefined directions, based on evaluating one or more predefined criteria, wherein at least one criterion of the one or more predefined criteria comprises whether the user equipment is located indoors or outdoors. detecting an orientation of an equipment coordinate frame defined for the user equipment relative to an earth coordinate frame defined for Earth; determining , based on the detected orientation, a set of beams defined in the equipment coordinate frame which does not include any beam pointing in one or more predefined directions in the earth coordinate frame ; and performing a beam sweep or scan on the determined set of beams; characterized by : J further comprising deciding whether the set of beams is to not include any beam pointing in at least one of the one or more predefined directions, based on evaluating one or more predefined criteria, wherein at least one criterion of the one or more predefined criteria comprises whether the user equipment is located indoors or outdoors.
A composition comprising water-soluble hydrolyzed clinoptilolite fragments, wherein the fragments have molecular weights ranging from 218 Daltons to 620 Daltons, and at least one sodium ion is associated with each water-soluble hydrolyzed clinoptilolite fragment, and the fragments include repeating units of 98 Daltons and 120 Daltons.
Shock-absorbing nanostructured polymer alloy comprising: • a (meth)acrylic polymer matrix comprising one or more (meth)acrylic polymer(s), said (meth)acrylic polymer matrix forming a (meth)acrylic network, and, • at least one polyborodimethylsiloxane (PBDMS) distributed in the (meth)acrylic polymer matrix, the polyborodimethylsiloxane forming a network, the polyborodimethylsiloxane network and the (meth)acrylic network being intertwined. • a (meth)acrylic polymer matrix comprising one or more (meth)acrylic polymer(s), said (meth)acrylic polymer matrix forming a (meth)acrylic network, and, • at least one polyborodimethylsiloxane (PBDMS) distributed in the (meth)acrylic polymer matrix, the polyborodimethylsiloxane forming a network,
An implant with anchoring device for heart valve disease comprising a cardiac valve prosthesis , at least two sets of anchoring needles , and at least two sets of anchoring needle releasing devices ; the most distal end of each of the anchoring needles being sharp; a distal section of each of the anchoring needles being made of a shape memory material to have a preset shape; a proximal end of each of the at least two anchoring needles is provided with an anti-disengagement end ; each of the anchoring needle releasing devices is detachably connected to the cardiac valve prosthesis ; each of the anchoring needle releasing devices comprises a delivery tube and a shaft ; a distal section of each of the anchoring needle releasing devices is in a preset shape, so as to enable a distal section of the delivery tube to bend wholly or partially, and to enable the distal end of the delivery tube to press tightly against the cardiac valve prosthesis or press tightly against autogenous tissue before the anchoring needles are moved; the most distal end of the delivery tube has a rigid section; a bendable part of the delivery tubes is a bent section (31121; 31221); a length d from the most distal end of the delivery tube to the most proximal end of the bent section (31121; 31221) is suitable for use of the delivery tube in a native heart valve annulus of a patient such that the length d is larger than or equal to 1/6 of a circumference of a circle formed by the minimum radius of the native heart valve annulus of the patient; the anchoring needles are pre-placed inside the distal section of the delivery tube in a stretched state; the shaft is arranged inside the delivery tube ; the anchoring needles are disposed beside a distal end of the shaft ; wherein the shaft is configured to be pushed to force the anchoring needles to move toward the distal ends of the delivery tubes ; the distal section of each of the anchoring needles is configured to restore to the preset shape after the anchoring needles are pushed out of the delivery tube ; and the anti-disengagement end of each of the anchoring needles is configured to limit the displacement of the cardiac valve prosthesis and the anchoring needles relative to a piercing position of autogenous tissue, thereby enabling the cardiac valve prosthesis to be fixed between autogenous tissue and the anti-disengagement end of each of the anchoring needles ; and wherein said implant with anchoring device for heart valve disease further comprises a supporting device and an operating member for the supporting device ; the operating member for the supporting device being fixedly connected to a proximal end of the supporting device ; and a distal section of the supporting device being bendable such that the distal section of the supporting device is configured to be pressed against autogenous tissue when the supporting device is released.
Head cushion or neck support cushion composed of a cover with a top side and a bottom side sewn up at the edge below a surround band , and a fastener on one side, which can be opened repeatedly, and a filling which is introduced through said fastener into the cushion , wherein the cover is unipartite and wherein said cover is pleated inwards at the edge situated opposite the fastener of the cushion to form a pocket for a grain cushion or a foam core, wherein the two edges of the pleats of the pocket are provided with interacting parts of a second fastener , which can be opened repeatedly.
A method for predicting a risk of breast cancer recurrence in a subject comprising steps of: (a) determining, in a sample obtained from the subject, the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A; and (b) calculating a risk score based upon the expression of the at least three genes; wherein the subject is an ER+/HER2- breast cancer patient. (a) determining, in a sample obtained from the subject, the expression of at least three genes from Table 3 or Table 9, wherein the at least three genes comprise at least EIF4EBP1, MRPS23, and TOP2A; and (b) calculating a risk score based upon the expression of the at least three genes;
A medical device system, comprising: a medical device configured to execute a program to provide neurostimulation therapy to a patient to alleviate a symptom of the patient; at least one non-transitory computer readable medium configured to be executed on an external device configured to adjust the program executed by the medical device; and the external device, wherein the at least one non-transitory computer readable medium is stored in the external device, and wherein the computer readable medium contains instructions for a first algorithm , wherein the first algorithm, when executed on the external device, is configured to: receive at least one qualitative measurement (X, X i ) from the patient regarding a status of the patient, receive at least one quantitative measurement (Y, Y1, Y2, Y3, Y4, Y5, Y i ) taken from the patient, and determine a wellness factor (Z) for the patient using the at least one qualitative measurement and the at least one quantitative measurement, wherein the wellness factor is indicative of a severity of the symptom, or is indicative of the status of the patient. a medical device configured to execute a program to provide neurostimulation therapy to a patient to alleviate a symptom of the patient; at least one non-transitory computer readable medium configured to be executed on an external device configured to adjust the program executed by the medical device; and the external device, wherein the at least one non-transitory computer readable medium is stored in the external device, and wherein the computer readable medium contains instructions for a first algorithm , wherein the first algorithm, when executed on the external device, is configured to: receive at least one qualitative measurement (X, X i ) from the patient regarding a status of the patient, receive at least one quantitative measurement (Y, Y1, Y2, Y3, Y4, Y5, Y i ) taken from the patient, and determine a wellness factor (Z) for the patient using the at least one qualitative measurement and the at least one quantitative measurement, wherein the wellness factor is indicative of a severity of the symptom, or is indicative of the status of the patient. receive at least one qualitative measurement (X, X i ) from the patient regarding a status of the patient, receive at least one quantitative measurement (Y, Y1, Y2, Y3, Y4, Y5, Y i ) taken from the patient, and determine a wellness factor (Z) for the patient using the at least one qualitative measurement and the at least one quantitative measurement, wherein the wellness factor is indicative of a severity of the symptom, or is indicative of the status of the patient.
Polycarbonate polymerized from an aromatic diol monomer, a carbonate precursor and a hydroxy-capping monomer represented by the following Formula 1: wherein R 1 and R 2 each independently represent hydrogen or a C1-C12 alkyl group, X is selected from a C1-C12 alkyl group, a C3-C14 cycloalkyl group, a C1-C12 alkylidene group, a C3-C14 cycloalkylidene group, a C6-C12 aryl group, a C7-C13 arylalkyl group, a C6-C18 arylene group, -O-, -S-, -CO-, and -SO 2 -, Y represents OH or and a and b each independently represent an integer of 1 to 4.