mhurhangee/patent-ind-claim-en huggingface dataset:
A method of identifying a human subject having, suspected of having, or at risk of developing, a renal cell carcinoma in need of a combination therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof and everolimus, the method comprising: assaying a biological sample obtained from the human subject and determining that the baseline level of angiopoietin-2 (Ang2) protein in the biological sample is higher than a control; and identifying the human subject having a higher concentration of Ang2 protein in the biological sample than a control as in need of the combination therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof and everolimus; wherein the baseline level of Ang2 protein is the concentration of Ang2 protein in the sample of the subject who has not been administered the combination therapy; and wherein the control is a sample obtained from a subject who is not in need of the combination therapy. assaying a biological sample obtained from the human subject and determining that the baseline level of angiopoietin-2 (Ang2) protein in the biological sample is higher than a control; and identifying the human subject having a higher concentration of Ang2 protein in the biological sample than a control as in need of the combination therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof and everolimus; wherein the baseline level of Ang2 protein is the concentration of Ang2 protein in the sample of the subject who has not been administered the combination therapy; and wherein the control is a sample obtained from a subject who is not in need of the combination therapy.
A double stranded RNAi agent comprising a sense strand complementary to an antisense strand, wherein said antisense strand comprises a region substantially complementary to the nucleotide sequence 5'-GGATGGGATTTCATGTAACCAAGA-3' (SEQ ID NO:2204), wherein the sense strand has a total of 21 nucleotides and the antisense strand has a total of 23 nucleotides, wherein said double stranded RNAi agent is represented by formula (III): wherein: i, j, k, and l are each independently 0 or 1, wherein i is 0, j is 1; p, p', q, and q' are each independently 0-6; each N a and N a ' independently represents an oligonucleotide sequence comprising 0-25 modified nucleotides, each sequence comprising at least two differently modified nucleotides; each N b and N b ' independently represents an oligonucleotide sequence comprising 0-10 modified nucleotides; wherein the modifications are 2'-O-methyl, 2'-fluoro, or both; each n p , n p ', n q , and n q ' independently represents an overhang nucleotide; XXX, YYY, ZZZ, X'X'X', Y'Y'Y', and Z'Z'Z' each independently represent one motif of three identical modifications on three consecutive nucleotides; wherein the Y nucleotides contain a 2'-fluoro modification and the Y' nucleotides contain a 2'-O-methyl modification; wherein said YYY motif occurs at positions 9, 10 and 11 when the duplex region is 21 nucleotides; wherein the sense strand is conjugated to at least one ligand, wherein the ligand is one or more GalNAc derivatives attached through a bivalent or trivalent branched linker; wherein "substantially complementary" means not more than 2 mismatched base pairs within 2 nucleotides of the 5' and/or 3' terminus; and wherein a phosphorothioate is present in the last 2 nucleotides at one or both termini. i, j, k, and l are each independently 0 or 1, wherein i is 0, j is 1; p, p', q, and q' are each independently 0-6; each N a and N a ' independently represents an oligonucleotide sequence comprising 0-25 modified nucleotides, each sequence comprising at least two differently modified nucleotides; each N b and N b ' independently represents an oligonucleotide sequence comprising 0-10 modified nucleotides; wherein the modifications are 2'-O-methyl, 2'-fluoro, or both; each n p , n p ', n q , and n q ' independently represents an overhang nucleotide; XXX, YYY, ZZZ, X'X'X', Y'Y'Y', and Z'Z'Z' each independently represent one motif of three identical modifications on three consecutive nucleotides; wherein the Y nucleotides contain a 2'-fluoro modification and the Y' nucleotides contain a 2'-O-methyl modification; wherein said YYY motif occurs at positions 9, 10 and 11 when the duplex region is 21 nucleotides; wherein the sense strand is conjugated to at least one ligand, wherein the ligand is one or more GalNAc derivatives attached through a bivalent or trivalent branched linker; wherein "substantially complementary" means not more than 2 mismatched base pairs within 2 nucleotides of the 5' and/or 3' terminus; and wherein a phosphorothioate is present in the last 2 nucleotides at one or both termini.
A method of directing just-in-time content preparation for a 5G media streaming, SGMS, network performed by at least one processor implementing a SGMS application provider, the method comprising: creating a content preparation template, by the SGMS application provider, wherein the content preparation template includes first information specifying instructions for content preparation, and second information specifying instructions for content output; establishing a first provisioning session between the SGMS application provider and a SGMS application function; transmitting the content preparation template to the SGMS application function and receiving a first acknowledgment from the SGMS application function that includes an indication of an allocation of at least one of content preparation resources and content distribution resources; updating the content preparation template, wherein the updating of the content preparation template is responsive to a request for content from one or more user devices prior to downlink streaming to the one or more user devices or to a request from the SGMS application provider prior to uplink streaming to the SGMS application provider; transmitting the updated content preparation template to the SGMS application function; and receiving an updated acknowledgement from the SGMS application function, wherein the updated acknowledgement indicates an updated allocation of at least one of SGMS content preparation resources and SGMS content distribution resources. creating a content preparation template, by the SGMS application provider, wherein the content preparation template includes first information specifying instructions for content preparation, and second information specifying instructions for content output; establishing a first provisioning session between the SGMS application provider and a SGMS application function; transmitting the content preparation template to the SGMS application function and receiving a first acknowledgment from the SGMS application function that includes an indication of an allocation of at least one of content preparation resources and content distribution resources; updating the content preparation template, wherein the updating of the content preparation template is responsive to a request for content from one or more user devices prior to downlink streaming to the one or more user devices or to a request from the SGMS application provider prior to uplink streaming to the SGMS application provider; transmitting the updated content preparation template to the SGMS application function; and receiving an updated acknowledgement from the SGMS application function, wherein the updated acknowledgement indicates an updated allocation of at least one of SGMS content preparation resources and SGMS content distribution resources.
An olefin polymerization process comprising vapor phase polymerization of at least one olefin monomer in one or more polymerization reactors wherein the polymerization process is carried out in an apparatus comprising: a) one or more reactor vessels to which olefin monomer and catalyst components can be added and which contain an agitated bed of forming polymer particles; b) means for removing a stream comprising polymer particles from the reactor; c) means for removing a gas-liquid stream comprising unreacted olefin monomers from the reactor; d) means for withdrawing a liquid recycle stream from the gas-liquid stream comprising unreacted olefin monomers; e) means for recycle a gas-liquid stream comprising unreacted olefin monomers to the reactor; wherein the process further comprises the steps of: i. withdrawing a gaseous stream from the stream comprising polymer particles; ii. contacting a liquid recycle stream from d) with said gaseous stream from i) thereby forming a mixture; iii. withdrawing a liquid stream from the mixture of ii) to form a vapor stream from the mixture of ii); iv. recycling the vapor stream from the mixture of ii) to the polymerization reactor. a) one or more reactor vessels to which olefin monomer and catalyst components can be added and which contain an agitated bed of forming polymer particles; b) means for removing a stream comprising polymer particles from the reactor; c) means for removing a gas-liquid stream comprising unreacted olefin monomers from the reactor; d) means for withdrawing a liquid recycle stream from the gas-liquid stream comprising unreacted olefin monomers; e) means for recycle a gas-liquid stream comprising unreacted olefin monomers to the reactor; i. withdrawing a gaseous stream from the stream comprising polymer particles; ii. contacting a liquid recycle stream from d) with said gaseous stream from i) thereby forming a mixture; iii. withdrawing a liquid stream from the mixture of ii) to form a vapor stream from the mixture of ii); iv. recycling the vapor stream from the mixture of ii) to the polymerization reactor.
An electric power tool comprising: a driving shaft that is rotated by a motor ; an output shaft on which a front-end tool is attachable; and a torque transmission mechanism that transmits a torque produced by the rotation of the driving shaft to the output shaft , wherein the torque transmission mechanism includes a magnet coupling including a driving magnet member coupled to a side of the driving shaft and a driven magnet member coupled to a side of the output shaft , the driving magnet member and the driven magnet member are provided such that respective magnetic surfaces face each other, S-poles and N-poles being alternately arranged on each of the magnetic surfaces, the magnet coupling has a function of applying an intermittent rotary impact force to the output shaft by losing synchronization, and the driving magnet member is coupled to the driving shaft so as to be rotatable relative to the driving shaft . a driving shaft that is rotated by a motor ; an output shaft on which a front-end tool is attachable; and a torque transmission mechanism that transmits a torque produced by the rotation of the driving shaft to the output shaft , wherein the torque transmission mechanism includes a magnet coupling including a driving magnet member coupled to a side of the driving shaft and a driven magnet member coupled to a side of the output shaft , the driving magnet member and the driven magnet member are provided such that respective magnetic surfaces face each other, S-poles and N-poles being alternately arranged on each of the magnetic surfaces, the magnet coupling has a function of applying an intermittent rotary impact force to the output shaft by losing synchronization, and the driving magnet member is coupled to the driving shaft so as to be rotatable relative to the driving shaft .
A computer-implemented method for ray tracing through a sub-surface region that includes an interface , the method comprising: when the ray tracing is before the interface , performing conventional ray tracing through the sub-surface region; and when the ray tracing is at the interface , computing a frequency-dependent outgoing ray direction from a point on the interface, wherein the computation is based at least in part on: an incoming ray direction, one or more surface normals, and a computed boundary integral that is based at least in part on the incoming ray direction and a frequency parameter. when the ray tracing is before the interface , performing conventional ray tracing through the sub-surface region; and when the ray tracing is at the interface , computing a frequency-dependent outgoing ray direction from a point on the interface, wherein the computation is based at least in part on: an incoming ray direction, one or more surface normals, and a computed boundary integral that is based at least in part on the incoming ray direction and a frequency parameter. one or more surface normals, and a computed boundary integral that is based at least in part on the incoming ray direction and a frequency parameter.
An image display device comprising: an image-light projection device configured to project an image light to a light transmission member to display speed information of a mobile object in a prescribed display area that is visually recognized by a driver of the mobile object via the light transmission member ; and a display controller configured to control the image-light projection device , wherein the display controller is configured to control the image-light projection device to display a plurality of items of passive information above the speed information in the prescribed display area and such that the plurality of items of passive information to be handled later by the driver are displayed in an operational sequence on an upper side of the prescribed display area . an image-light projection device configured to project an image light to a light transmission member to display speed information of a mobile object in a prescribed display area that is visually recognized by a driver of the mobile object via the light transmission member ; and a display controller configured to control the image-light projection device , wherein the display controller is configured to control the image-light projection device to display a plurality of items of passive information above the speed information in the prescribed display area and such that the plurality of items of passive information to be handled later by the driver are displayed in an operational sequence on an upper side of the prescribed display area .
A device for storing objects, having - a first drawer element , which is movably mounted via at least one pullout guide between a closed position and a maximally open position, which pullout guide comprises a stationary guide rail and a slide rail movable in relation to the guide rail , on which the first drawer element is supported; - a second drawer element , which is movably mounted via at least one second pullout guide between a closed position and a maximally open position, which pullout guide comprises a stationary guide rail and a slide rail movable in relation to the guide rail , on which the second drawer element is supported; - wherein the slide rail of the first pullout guide is movable independently of the slide rail of the second pullout guide , and a coupling mechanism , by means of which the second drawer element is movable into a moderately open position between the closed position and the maximally open position in the event of a movement of the first drawer element from the closed position into the maximally open position, wherein the coupling mechanism is detachable to be able to move the second drawer element independently of the first drawer element into the maximally open position or the closed position, characterized in that the first pullout guide comprises a middle rail , which is arranged between the slide rail and the guide rail , and the second drawer element is movable via the coupling mechanism at the same speed as the middle rail . - a first drawer element , which is movably mounted via at least one pullout guide between a closed position and a maximally open position, which pullout guide comprises a stationary guide rail and a slide rail movable in relation to the guide rail , on which the first drawer element is supported; - a second drawer element , which is movably mounted via at least one second pullout guide between a closed position and a maximally open position, which pullout guide comprises a stationary guide rail and a slide rail movable in relation to the guide rail , on which the second drawer element is supported; - wherein the slide rail of the first pullout guide is movable independently of the slide rail of the second pullout guide , and a coupling mechanism , by means of which the second drawer element is movable into a moderately open position between the closed position and the maximally open position in the event of a movement of the first drawer element from the closed position into the maximally open position, wherein the coupling mechanism is detachable to be able to move the second drawer element independently of the first drawer element into the maximally open position or the closed position, characterized in that the first pullout guide comprises a middle rail , which is arranged between the slide rail and the guide rail , and the second drawer element is movable via the coupling mechanism at the same speed as the middle rail .
Sealing tool for a tray sealing machine , comprising: an upper tool , a lower tool with a main body , which has a tray depression for receiving at least a part of a tray to be sealed, and with a tray carrier , wherein a gas channel runs through said tray carrier , wherein said tray carrier comprises a first plate with a first pressing surface and a second plate with a second pressing surface and said first plate has a first depression extending from said first pressing surface , wherein said first depression forms at least a section of said gas channel when said first plate and said second plate are pressed against each other at said first and the second pressing surface , respectively, characterized in that a protrusion is provided on said second pressing surface and, in the pressed-on state, said protrusion is configured to extend into said first depression . an upper tool , a lower tool with a main body , which has a tray depression for receiving at least a part of a tray to be sealed, and with a tray carrier , wherein a gas channel runs through said tray carrier , wherein said tray carrier comprises a first plate with a first pressing surface and a second plate with a second pressing surface and said first plate has a first depression extending from said first pressing surface , wherein said first depression forms at least a section of said gas channel when said first plate and said second plate are pressed against each other at said first and the second pressing surface , respectively, characterized in that a protrusion is provided on said second pressing surface and, in the pressed-on state, said protrusion is configured to extend into said first depression .
Projectile , in particular of a deformation bullet or a partial fragmentation bullet, comprising a cylindrical solid base end section and a press end section with a central press recess introduced by pressing, in particular deep drawing, and a wall delimiting the press recess , which is formed into an ogive-shaped tip, wherein the wall is formed with at least two through-slits which delimit at least two wall sections that are structurally separated in the circumferential direction, characterized in that adjacent side edges of the wall sections at least partially contact each other in the circumferential direction, in particular wherein, in the contact region of the wall sections, a cavity formed by the press recess is enclosed in the circumferential direction.
A label-affixing machine for affixing a label , which is conveyed by a label conveying body , to a back surface of a product being conveyed, characterised in that the label-affixing machine comprises: a label holding unit configured to hold the label so that an adhesive surface of the label faces outward; a pressing mechanism configured to press the label conveying body , which is disposed on a side facing the label holding unit , against the adhesive surface of the held label by moving the label conveying body toward the label holding unit ; and a controller configured to control drive of the label conveying body and the pressing mechanism to affix the label to the back surface of the product . a label holding unit configured to hold the label so that an adhesive surface of the label faces outward; a pressing mechanism configured to press the label conveying body , which is disposed on a side facing the label holding unit , against the adhesive surface of the held label by moving the label conveying body toward the label holding unit ; and a controller configured to control drive of the label conveying body and the pressing mechanism to affix the label to the back surface of the product .
A method for activating a battery cell, which activates the battery cell comprising a positive electrode coated with a nickel cobalt manganese (NCM) positive electrode material, into which lithium nickel oxide (LNO) is added or mixed, the method comprising: a step of charging the battery cell; and a step of discharging the battery cell, wherein, in the step of charging the battery cell, the battery cell is charged under a charging condition of C-rate of 0.1 C to 0.5 C in a state of being heated at a temperature of 45°C to 60°C; wherein the battery cell is charged in a state of being fully discharged at a charging rate of 0%, a first pressure is applied to the battery cell in a first charging interval, which is determined from a charging rate of 0% to a reference charging rate and a second pressure applied to the battery cell in a second charging interval, which is determined from the reference charging rate to a charging rate of 100%, and the first pressure and the second pressure are different. a step of charging the battery cell; and a step of discharging the battery cell, wherein, in the step of charging the battery cell, the battery cell is charged under a charging condition of C-rate of 0.1 C to 0.5 C in a state of being heated at a temperature of 45°C to 60°C; wherein the battery cell is charged in a state of being fully discharged at a charging rate of 0%, a first pressure is applied to the battery cell in a first charging interval, which is determined from a charging rate of 0% to a reference charging rate and a second pressure applied to the battery cell in a second charging interval, which is determined from the reference charging rate to a charging rate of 100%, and the first pressure and the second pressure are different.
A tire load estimating method comprising: a step of detecting an acceleration waveform of a tire in a tire radial direction from an output of an acceleration sensor disposed on an inner surface side of a tire tread ; a step of differentiating the acceleration waveform in the tire radial direction to obtain a differential acceleration waveform; a step of calculating a ground contact time and a rotation time of the tire from the differential acceleration waveform; a step of calculating a ground contact time ratio which is a ratio between the ground contact time and the rotation time; and a step of estimating a load acting on the tire from the calculated ground time ratio. a step of detecting an acceleration waveform of a tire in a tire radial direction from an output of an acceleration sensor disposed on an inner surface side of a tire tread ; a step of differentiating the acceleration waveform in the tire radial direction to obtain a differential acceleration waveform; a step of calculating a ground contact time and a rotation time of the tire from the differential acceleration waveform; a step of calculating a ground contact time ratio which is a ratio between the ground contact time and the rotation time; and a step of estimating a load acting on the tire from the calculated ground time ratio.
An isolated antibody, or an antigen binding fragment thereof, for use in treating a cancerous condition, wherein the antibody or an antigen binding fragment thereof specifically binds to a cysteine knot region of human activin A, said region spanning amino acids C11-S33 and amino acids C81-E111 of the sequence set forth in SEQ ID NO:225, and inhibits binding of human activin A to human activin A receptor.