A method of analyzing liquid chromatography data comprising: collecting, by a data processing system, first volume fractions data from a first liquid chromatography column for a first absorbance wavelength of light λ1 from a first run of a liquid chromatography process on a mixture, wherein the first liquid chromatography column screens for a first characteristic of the mixture, wherein a volume fraction is the volume of a component of interest in a mixture devised by the volume of all components in the mixture; normalizing a first relative peak area for a first volume of a component of interest in the mixture for the first absorbance wavelength λ1 to obtain a first set of purity quotient values PQ1; collecting, by the data processing system, second volume fractions data from a second liquid chromatography column for a second absorbance wavelength of light λ2 from a second run of a liquid chromatography process on the mixture, wherein the second liquid chromatography column screens for a second characteristic of the mixture; normalizing a second relative peak area for the second volume of the component of interest in the mixture for the second absorbance wavelength λ2 to obtain a second set of purity quotient values PQ2; storing the values PQ1 and PQ2 in a memory; calculating, by the data processing system, a difference between values PQ1 and PQ2 for each volume fraction location of the first and second volumes to obtain a first set of purity quotient difference ("PQD") values, wherein a fraction is any arbitrary or variable volume of liquid that can be used to calculate a relative area of absorbance; displaying in a graphical display the first set of PQD values; and determining which volume fractions to pool together based on the display of the first set of PQD values. collecting, by a data processing system, first volume fractions data from a first liquid chromatography column for a first absorbance wavelength of light λ1 from a first run of a liquid chromatography process on a mixture, wherein the first liquid chromatography column screens for a first characteristic of the mixture, wherein a volume fraction is the volume of a component of interest in a mixture devised by the volume of all components in the mixture; normalizing a first relative peak area for a first volume of a component of interest in the mixture for the first absorbance wavelength λ1 to obtain a first set of purity quotient values PQ1; collecting, by the data processing system, second volume fractions data from a second liquid chromatography column for a second absorbance wavelength of light λ2 from a second run of a liquid chromatography process on the mixture, wherein the second liquid chromatography column screens for a second characteristic of the mixture; normalizing a second relative peak area for the second volume of the component of interest in the mixture for the second absorbance wavelength λ2 to obtain a second set of purity quotient values PQ2; storing the values PQ1 and PQ2 in a memory; calculating, by the data processing system, a difference between values PQ1 and PQ2 for each volume fraction location of the first and second volumes to obtain a first set of purity quotient difference ("PQD") values, wherein a fraction is any arbitrary or variable volume of liquid that can be used to calculate a relative area of absorbance; displaying in a graphical display the first set of PQD values; and determining which volume fractions to pool together based on the display of the first set of PQD values. <EOS>