mhurhangee/patent-ind-claim-en huggingface dataset:
A pharmaceutical composition comprising: a) from about 10% to about 25% w/w of a solid dispersion comprising ledipasvir dispersed within a polymer matrix formed by copovidone, wherein the weight ratio of ledipasvir to copovidone in the solid dispersion is about 1:1 and wherein the ledipasvir has the formula: and is amorphous; b) from about 35% to about 45% w/w of sofosbuvir having the formula: wherein the sofosbuvir is crystalline and the crystalline sofosbuvir has XRPD 2θ-reflections (°± 0.2θ) at: 6.1 and 12.7; c) from about 5% to about 25% w/w of lactose monohydrate; d) from about 5% to about 25% w/w of microcrystalline cellulose; e) from about 1% to about 10% w/w of croscarmellose sodium; f) from about 0.5% to about 3% w/w of colloidal silicon dioxide; and g) from about 0.1% to about 3% w/w of magnesium stearate. a) from about 10% to about 25% w/w of a solid dispersion comprising ledipasvir dispersed within a polymer matrix formed by copovidone, wherein the weight ratio of ledipasvir to copovidone in the solid dispersion is about 1:1 and wherein the ledipasvir has the formula: and is amorphous; b) from about 35% to about 45% w/w of sofosbuvir having the formula: wherein the sofosbuvir is crystalline and the crystalline sofosbuvir has XRPD 2θ-reflections (°± 0.2θ) at: 6.1 and 12.7; c) from about 5% to about 25% w/w of lactose monohydrate; d) from about 5% to about 25% w/w of microcrystalline cellulose; e) from about 1% to about 10% w/w of croscarmellose sodium; f) from about 0.5% to about 3% w/w of colloidal silicon dioxide; and g) from about 0.1% to about 3% w/w of magnesium stearate.
A filled composition comprising a substrate, functional filler, and an inorganic additive for reducing the odour of the filled composition, wherein the inorganic additive is present in an amount sufficient to reduce the odour of the filled composition absent the inorganic additive, wherein the functional filler is a mineral filler and comprises, consists essentially, or consists of, or is a phyllosilicate mineral, wherein the inorganic additive is a mineral additive other than the functional filler, the inorganic additive being a silica-containing or silicate mineral other than wollastonite, wherein the phyllosilicate mineral is talc, wherein the substrate is a polymer, and wherein odour is determined according to standard VDA 270.
A composition comprising: a. one or more agents that reduce the level of an ikaros family member transcription factor in a cell, wherein the one or more agents are selected from the group consisting of pomalidomide and lenalidomide; and b. one or more agents that inhibit TGFβ signaling, wherein the one or more agents that inhibit TGFβ signaling comprise a TGFβ receptor inhibitor, and wherein said TGFβ receptor inhibitor is selected from the group consisting of ALK5 inhibitor II, LY364947, DMH1, and A83-01. a. one or more agents that reduce the level of an ikaros family member transcription factor in a cell, wherein the one or more agents are selected from the group consisting of pomalidomide and lenalidomide; and b. one or more agents that inhibit TGFβ signaling, wherein the one or more agents that inhibit TGFβ signaling comprise a TGFβ receptor inhibitor, and wherein said TGFβ receptor inhibitor is selected from the group consisting of ALK5 inhibitor II, LY364947, DMH1, and A83-01.
A digital repeater system for repeating RF signals, the digital repeater system comprising: a receiving section configured for receiving an RF input signal (RF IN ) that includes at least one frequency band (B) having at least one subband associated with at least one communication channel of a telecommunications network, the receiving section being configured to digitize the RF input signal (RF IN ) to obtain a digital signal (IF IN ); a filter device comprising at least one digital filter (211 1 -211 N ) having a passband (PB) for digitally filtering the digital signal (IF IN ), the at least one digital filter (211 1 -211 N ) being configurable by setting filter coefficients; a gain control device (213 1 -213 N ) configurable to set a gain (G) of at least a portion of the digital signal (IF IN ); at least one transmitting section configured for transmitting an RF output signal (RF OUT ) and for converting the digital signal (IF IN ) to the RF output signal (RF OUT ) for transmission; and a control unit adapted to configure the filter coefficients of the at least one digital filter (211 1 -211 N ) in response to a change in the gain setting of the gain control device (213 1 -213 N ), wherein the filter coefficients are configured based on the change in the gain setting to optimize group delay. a receiving section configured for receiving an RF input signal (RF IN ) that includes at least one frequency band (B) having at least one subband associated with at least one communication channel of a telecommunications network, the receiving section being configured to digitize the RF input signal (RF IN ) to obtain a digital signal (IF IN ); a filter device comprising at least one digital filter (211 1 -211 N ) having a passband (PB) for digitally filtering the digital signal (IF IN ), the at least one digital filter (211 1 -211 N ) being configurable by setting filter coefficients; a gain control device (213 1 -213 N ) configurable to set a gain (G) of at least a portion of the digital signal (IF IN ); at least one transmitting section configured for transmitting an RF output signal (RF OUT ) and for converting the digital signal (IF IN ) to the RF output signal (RF OUT ) for transmission; and a control unit adapted to configure the filter coefficients of the at least one digital filter (211 1 -211 N ) in response to a change in the gain setting of the gain control device (213 1 -213 N ), wherein the filter coefficients are configured based on the change in the gain setting to optimize group delay.
A method for transmitting data, the method comprising: generating a medium access control, MAC, protocol data unit, PDU, including a plurality of payloads associated with a same security association from a plurality of connections, a generic MAC header, GMH, and a multiplexing extended header, MEH; and transmitting a signal derived from the MAC PDU; wherein the plurality of payloads are multiplexed and encrypted together in the MAC PDU, and wherein each connection of the plurality of connections with payloads in the MAC PDU is identified based on the GMH and the MEH. generating a medium access control, MAC, protocol data unit, PDU, including a plurality of payloads associated with a same security association from a plurality of connections, a generic MAC header, GMH, and a multiplexing extended header, MEH; and transmitting a signal derived from the MAC PDU; wherein the plurality of payloads are multiplexed and encrypted together in the MAC PDU, and wherein each connection of the plurality of connections with payloads in the MAC PDU is identified based on the GMH and the MEH.
An overvoltage protection circuit having a control unit for use as a second switch in a method for separating an electrical connection of an overvoltage protection element , interposed between two connection points , from one of these connection points , having a first feed path that electrically connects a connector of the overvoltage protection element to the one of the connection points , wherein arranged in the first feed path is a first opening switch that is opened triggered by a change in pressure and/or a change in pressure of the overvoltage protection element , wherein when the first switch opens the flowing current is switched to a second feed path that is switched parallel to the first feed path , wherein in the second feed path the second opening switch is arranged for reliably separating follow-on current, and wherein the opening of the second switch occurs at a time delay relative to opening of the first switch , characterized in that the control unit is embodied as a trailing contact and has a device for constricting the electric arc, wherein the device for constricting the electric arc has at least one wire and three insulating plates , wherein the three plates are arranged extended essentially parallel to one another, wherein the wire of the second switch - runs, with a first segment , between the first outer plate and the center plate , - furthermore traverses, with a second segment , a connecting end face of the center plate and in the second segment is guided on a first fixing point of the first outer plate and on a second fixing point of the second outer plate , and, - then, with a third segment , runs essentially parallel to the first segment between the second outer plate and the center plate . - runs, with a first segment , between the first outer plate and the center plate , - furthermore traverses, with a second segment , a connecting end face of the center plate and in the second segment is guided on a first fixing point of the first outer plate and on a second fixing point of the second outer plate , and, - then, with a third segment , runs essentially parallel to the first segment between the second outer plate and the center plate .
A composition for use in treating facioscapulohumeral muscular dystrophy (FSHD) in a subject, which composition comprises a therapeutically effective amount of a substance which increases the level and/or activity of a protein encoded by a structural maintenance of chromosomes flexible hinge domain containing 1 ( SMCHD1 ) gene in cells of the subject, wherein the substance comprises a nucleic acid segment encoding a polypeptide that has an amino acid sequence identity of at least 80%, preferably at least 90%, more preferably at least 95%, most preferably 100% with the SMCHD1 protein of SEQ ID:NO 1.
Process comprising the process steps of: a) initially charging an olefin; b) adding a compound of formula (I): where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are selected from: -H, -(C 1 -C 12 )-alkyl, -(C 6 -C 20 )-aryl; c) adding a Pt compound capable of forming a complex; d) adding a bromine compound or an iodine compound; e) feeding in CO and H 2 ; f) heating the reaction mixture from a) to e), with conversion of the olefin to an aldehyde. a) initially charging an olefin; b) adding a compound of formula (I): where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are selected from: -H, -(C 1 -C 12 )-alkyl, -(C 6 -C 20 )-aryl; c) adding a Pt compound capable of forming a complex; d) adding a bromine compound or an iodine compound; e) feeding in CO and H 2 ; f) heating the reaction mixture from a) to e), with conversion of the olefin to an aldehyde.
A turbomachine part for an aircraft comprising a wall which comprises a first zone , a second zone , and a transition zone located between the first zone and the second zone , an array of riblets being formed on the first zone , on the second zone , and also on the transition zone , the riblets being oriented parallel to a principal direction of airflow flowing along the wall; the riblets comprising an apex (S), a height (H1, H2, Ht), a width (L1, L2, Lt), and a spacing (E1, E2, Et) which corresponds to the distance between the apices (S) of adjacent riblets ; the height (H1), the width (L1), and the spacing (E1) of the riblets of the first zone being constant on the first zone ; the height (H2), the width (L2), and the spacing (E2) of the riblets of the second zone being constant on the second zone ; the height (Ht), the width (Lt), and the spacing (Et) of the riblets of the transition zone evolving along said transition zone so as to move from the height (H1), the width (L1), and the spacing (E1) of the riblets formed on the first zone at a first end of the transition zone , to the height (H2), the width (L2), and the spacing (E2) of the riblets formed on the second zone at a second end of the transition zone ; characterized in that the transition zone comprises a central portion located between the first and the second end on which the riblets comprise both the height (Ht) and the width (Lt) which are respectively equal to the height (H1) and the width (L1) of the riblets of the first zone , and also a spacing (Et) equal to the spacing (E2) of the riblets of the second zone .
A method of producing a veneered element , comprising - providing a substrate , - applying a sub-layer on a surface of the substrate , - applying a veneer layer comprising a wood veneer on the sub-layer , - applying pressure to the veneer layer and/or the substrate , such that at least a portion of the sub-layer permeates through cracks and/or holes of the veneer layer , characterized in that it comprises the steps of: - controlling a design of the veneer by controlling permeation of the sub-layer through the veneer layer, wherein permeation is varied by applying a varying fluid pressure, the fluid pressure being controlled by generating a gas pressure in the sub-layer , wherein the gas pressure is generated by including chemical blowing agents in the sub-layer . - providing a substrate , - applying a sub-layer on a surface of the substrate , - applying a veneer layer comprising a wood veneer on the sub-layer , - applying pressure to the veneer layer and/or the substrate , such that at least a portion of the sub-layer permeates through cracks and/or holes of the veneer layer , characterized in that it comprises the steps of: - controlling a design of the veneer by controlling permeation of the sub-layer through the veneer layer, - controlling a design of the veneer by controlling permeation of the sub-layer through the veneer layer,
Structural element , in particular for use in pieces of furniture, the structural element comprising: - a first electrically conductive layer and a second electrically conductive layer ; - an electrically insulating separating layer , the separating layer being arranged in a cross-section of the structural element between the first conductive layer and the second conductive layer and adjacent to the first conductive layer and the second conductive layer ; characterized in that - at least one of the first conductive layer and the second conductive layer comprises a mixture of binder, cellulosic particles and electrically conductive particles. - a first electrically conductive layer and a second electrically conductive layer ; - an electrically insulating separating layer , the separating layer being arranged in a cross-section of the structural element between the first conductive layer and the second conductive layer and adjacent to the first conductive layer and the second conductive layer ; - at least one of the first conductive layer and the second conductive layer comprises a mixture of binder, cellulosic particles and electrically conductive particles.
A wavelength-selective transmissive glass having a light transmittance T more than 315 nm and 400 nm or less at a wavelength of more than 315 nm and 400 nm or less represented by the formula shown below of 1% or more in terms of a plate thickness of 6 mm and a light transmittance T 315 nm or less at a wavelength of 315 nm or less represented by the formula shown below of 60% or less in terms of a plate thickness of 6 mm: T more than 315 nm and 400 nm or less = ∑ k = more than 315 400 A k × T k / ∑ k = more than 315 400 A k T 315 nm or less = ∑ k = 300 315 A k × T k / ∑ k = 300 400 A k . wherein A k is a weighting factor at a wavelength k (nm) for calculating T (light transmittance) defined in ISO-9050:2003, and T k is a transmittance at the wavelength k (nm) in terms of a plate thickness of 6 mm, wherein the wavelength-selective transmissive glass comprises, as represented by mass% based on oxides, SiO 2 : 60 to 80%, Al 2 O 3 : 0 to 7%, MgO: 0 to 10%, CaO: 4 to 20%, Na 2 O: 7 to 20%, and K 2 O: 0 to 10%, as a glass matrix composition, and wherein as represented by mass% based on oxides, a total iron content represented by Fe 2 O 3 is 0.04 to 0.15%, CeO 2 is 0.35 to 0.45%, TiO 2 is 0 to 0.2%, SnO 2 is 0 to 0.2%, CeO 2 +3×TiO 2 +6×SnO 2 is 0.41 to 0.5, and a value of Fe-Redox is 25 to 65%, wherein the value Fe-Redox is the proportion of Fe <2+> content in terms of Fe 2 O 3 to the total iron content in terms of Fe 2 O 3 . wherein A k is a weighting factor at a wavelength k (nm) for calculating T (light transmittance) defined in ISO-9050:2003, and T k is a transmittance at the wavelength k (nm) in terms of a plate thickness of 6 mm, wherein the wavelength-selective transmissive glass comprises, as represented by mass% based on oxides, SiO 2 : 60 to 80%, Al 2 O 3 : 0 to 7%, MgO: 0 to 10%, CaO: 4 to 20%, Na 2 O: 7 to 20%, and K 2 O: 0 to 10%, as a glass matrix composition, and wherein as represented by mass% based on oxides, a total iron content represented by Fe 2 O 3 is 0.04 to 0.15%, CeO 2 is 0.35 to 0.45%, TiO 2 is 0 to 0.2%, SnO 2 is 0 to 0.2%, CeO 2 +3×TiO 2 +6×SnO 2 is 0.41 to 0.5, and a value of Fe-Redox is 25 to 65%, wherein the value Fe-Redox is the proportion of Fe <2+> content in terms of Fe 2 O 3 to the total iron content in terms of Fe 2 O 3 .
A method of determining the performance of an optical communications link , the method comprising the steps of: i) determining an OSNR (optical signal to noise ratio) to BER (bit error rate) relationship for an optical transponder ; ii) connecting the optical transponder to an optical communications link ; iii) measuring the bit error rate of the optical communications link; and iv) determining the OSNR for the optical communications link in accordance with the relationship determined in step i) and the measurement made in step iii), characterised in that the method comprises the further steps of v) performing steps i) to iv) using a plurality of transponder modulation formats to determine a plurality of OSNR-BER relationships and determining the performance of the optical communications link in accordance with the plurality of OSNR-BER relationships. i) determining an OSNR (optical signal to noise ratio) to BER (bit error rate) relationship for an optical transponder ; ii) connecting the optical transponder to an optical communications link ; iii) measuring the bit error rate of the optical communications link; and iv) determining the OSNR for the optical communications link in accordance with the relationship determined in step i) and the measurement made in step iii), characterised in that the method comprises the further steps of v) performing steps i) to iv) using a plurality of transponder modulation formats to determine a plurality of OSNR-BER relationships and determining the performance of the optical communications link in accordance with the plurality of OSNR-BER relationships.
A cartridge holder having a distal end and a proximal end, the cartridge holder comprising a coupling housing portion in which a cartridge can be inserted at least partly, the coupling housing portion being configured to be coupled to a part of a drug delivery device, a fixing member being connected with the coupling housing portion , wherein the fixing member is flexible and integrally formed with the coupling housing portion , the fixing member being moveable radially inwardly to a position in which the fixing member is suitable for securing the cartridge against distal displacement of the cartridge , characterized in that the coupling housing portion comprises a thread and is configured to be coupled with a needle unit , wherein the fixing member has a side which is connected with the coupling housing portion , an edge of the fixing member extending from one end of the side which is connected with the coupling housing portion to the other end of this side , the edge being separated from the coupling housing portion by a cut-out , wherein the fixing member comprises a catch portion formed on an inner side of the fixing member .
Pretreatment installation for carrying out pretreatments of workpieces for surface treatments, with a pretreatment chamber for receiving the workpieces during the pretreatment, and a distributor unit for distributing the pretreatment media in the pretreatment chamber , wherein the distributor unit comprises a distribution line for distributing the pretreatment media in the horizontal direction (X, Y), wherein the distribution line comprises a plurality of dispensing devices for dispensing the pretreatment media into a pretreatment region inside the pretreatment chamber , wherein the flow path for the liquid media of the distribution line has a constant drop towards the emptying device for emptying the distribution line , characterised in that the distributor unit can be moved vertically in the pretreatment chamber wherein the distributor unit is arranged in a ring around the pretreatment region .
A non-naturally occurring microorganism having a 1,3-butanediol (1,3-BDO) pathway, wherein the microorganism comprises the following 1,3-BDO pathway enzymes: (a) a deoxyribose-5-phosphate aldolase (DERA) comprising an amino acid sequence at least 80% identical to SEQ ID NO: 19, 21, or 22 that catalyzes condensation of two acetaldehydes to produce 3-hydroxybutanal; and (b) an aldo-ketoreductase comprising an amino acid sequence at least 70% identical to SEQ ID NO: 25, oxidoreductase, aldehyde reductase, or alcohol dehydrogenase that reduces the 3-hydroxybutanal to 1,3-BDO. (a) a deoxyribose-5-phosphate aldolase (DERA) comprising an amino acid sequence at least 80% identical to SEQ ID NO: 19, 21, or 22 that catalyzes condensation of two acetaldehydes to produce 3-hydroxybutanal; and (b) an aldo-ketoreductase comprising an amino acid sequence at least 70% identical to SEQ ID NO: 25, oxidoreductase, aldehyde reductase, or alcohol dehydrogenase that reduces the 3-hydroxybutanal to 1,3-BDO.
A wound debridement material comprising: a solid open-cell hydrophilic porous foam soaked by a liquid such that the foam has a moisture content from 20 wt. % to 60 wt. %; wherein the solid porous foam has a texture that permits the wound debridement material, when applied in frictional contact across at least a portion of a wound surface of a patient including tissue to be removed, to remove the tissue from the wound surface via adherence of the tissue to the wound debridement material without leaving solid debris of the foam on the wound surface; characterised in that the foam has a stiffness of 30 Shore A durometer to 70 Shore A durometer; a compression stiffness of the foam is from 4.0 kPa at 25% compression to 9.0 kPa at 50% compression; and a density from 145kg/m3 to 270 kg/m3. a solid open-cell hydrophilic porous foam soaked by a liquid such that the foam has a moisture content from 20 wt. % to 60 wt. %; wherein the solid porous foam has a texture that permits the wound debridement material, when applied in frictional contact across at least a portion of a wound surface of a patient including tissue to be removed, to remove the tissue from the wound surface via adherence of the tissue to the wound debridement material without leaving solid debris of the foam on the wound surface; characterised in that the foam has a stiffness of 30 Shore A durometer to 70 Shore A durometer; a compression stiffness of the foam is from 4.0 kPa at 25% compression to 9.0 kPa at 50% compression; and a density from 145kg/m3 to 270 kg/m3.