mhurhangee/patent-ind-claim-en huggingface dataset:
Process for the preparation of a compound of the formula (I), wherein R 1 is hydrogen or halogen; R 2 is hydrogen, halogen or cyano; n is 0-7, particularly n is 2-3, more particularly n is 2; comprising any of the following steps: Step a) the formation of compound of formula (IV), via nucleophilic aromatic substitution between compound of formula (II), and compound (III), Step b) the formation of compound of formula (VI), via Suzuki-Miyaura coupling reaction between compound of formula (IV) and compound (V), Step c) the formation of compound of formula (I), via deprotection of formula (VI). wherein R 1 is hydrogen or halogen; R 2 is hydrogen, halogen or cyano; n is 0-7, particularly n is 2-3, more particularly n is 2; comprising any of the following steps: Step a) the formation of compound of formula (IV), via nucleophilic aromatic substitution between compound of formula (II), and compound (III), Step b) the formation of compound of formula (VI), via Suzuki-Miyaura coupling reaction between compound of formula (IV) and compound (V), Step c) the formation of compound of formula (I), via deprotection of formula (VI). Step a) the formation of compound of formula (IV), via nucleophilic aromatic substitution between compound of formula (II), and compound (III), Step b) the formation of compound of formula (VI), via Suzuki-Miyaura coupling reaction between compound of formula (IV) and compound (V), Step c) the formation of compound of formula (I), via deprotection of formula (VI).
Process for the production of an element, in particular a cable with, at the surface, a coefficient of friction reduced in comparison with silicone, where the element comprises externally a silicone-like substrate material which is a crosslinkable plastic which in the crosslinked final state has a coefficient of friction comparable with that of silicone, examples being silicones, polyurethanes, polyamides, polytetrafluoroethylene (PTFE), ethylene-tetrafluoroethylene (ETFE), perfluorinated ethylene-propylene (FEP), perfluoroalkoxy (PFA) and also copolymers thereof, where the substrate material is configured in a first step to give an at least to some extent uncrosslinked intermediate product , then in a second step solid particles are introduced into the surface and finally in a third step the uncrosslinked substrate material is crosslinked, characterized in that mica particles in platelet form are introduced as solid particles, where for this purpose the uncrosslinked intermediate product in the second step is passed through a storage container with solid particles present therein and the storage container is subjected to oscillation or turbulence and/or an air stream is produced in the storage container so that the solid particles are mechanically impressed into the surface and the solid particles are distributed across the surface, where at least some of the solid particles form scale-like projections from the surface .
A modified polypeptide which binds Factor VIII wherein the modified polypeptide comprises an amino acid sequence of the D' domain of human Von Willebrand Factor (VWF) as shown in SEQ ID NO:3 in which the sequence comprises a modification selected from the group consisting of SEQ ID NO:5 (S764G/S766Y), SEQ ID NO:6 (S764P/S766I), SEQ ID NO:7 (S764P/S766M), SEQ ID NO:8 (S764V/S766Y), SEQ ID NO:9 (S764E/S766Y), SEQ ID NO:10 (S764Y/S766Y), SEQ ID NO:11 (S764L/S766Y), SEQ ID NO:12 (S764P/S766W), SEQ ID NO:13 (S766W/S806A), SEQ ID NO:14 (S766Y/P769K), SEQ ID NO:15 (S766Y/P769N), SEQ ID NO:16 (S766Y/P769R) and SEQ ID NO:17 (S764P/S766L), such that the modified polypeptide binds to Factor VIII with an off rate at least 5 fold lower, preferably at least 10 fold lower, than a reference polypeptide comprising an unmodified SEQ ID NO:3.
A method of preserving a lung ex vivo for transplant, the method comprising: perfusing a lung with a perfusion fluid comprising nitric oxide (NO) and/or a NO donor and red blood cells; the perfusion fluid being in contact with a gas, wherein NO concentration in the gas delivered to the perfusion fluid is in a range from 0.1 ppm to 300 ppm; monitoring methemoglobin in the perfusion fluid; and adjusting the amount of NO and/or NO donor provided to the lung by the perfusion fluid if the methemoglobin levels meet or exceed 12% as a percentage of methemoglobin relative to the red blood cells, wherein adjusting the amount of NO provided to the lung by the perfusion fluid comprises decreasing a NO concentration in the gas delivered to the perfusion fluid. perfusing a lung with a perfusion fluid comprising nitric oxide (NO) and/or a NO donor and red blood cells; the perfusion fluid being in contact with a gas, wherein NO concentration in the gas delivered to the perfusion fluid is in a range from 0.1 ppm to 300 ppm; monitoring methemoglobin in the perfusion fluid; and adjusting the amount of NO and/or NO donor provided to the lung by the perfusion fluid if the methemoglobin levels meet or exceed 12% as a percentage of methemoglobin relative to the red blood cells, wherein adjusting the amount of NO provided to the lung by the perfusion fluid comprises decreasing a NO concentration in the gas delivered to the perfusion fluid.
A random access method, comprising: receiving, at a media access control, MAC, entity from a radio resource control, RRC, entity in a communications apparatus, a first RRC message including to-be-transmitted data; determining, at the MAC entity, a coverage level of the communications apparatus according to a measured RSRP; determining, at the MAC entity, according to a data amount control threshold corresponding to the coverage level, that a data amount supported by the coverage level does not meet a size of the first RRC message, wherein the data amount control threshold is preset by a base station; sending, at the MAC entity to the RRC entity, indication information, wherein the indication information indicates that the to-be-transmitted data are not transmitted in a random access procedure; receiving, at the MAC entity, a second RRC message from the RRC entity, wherein the second RRC message does not include the to-be-transmitted data; sending, at the MAC entity according to the second RRC message, a random access preamble to the base station; and receiving, at the MAC entity, a random access response from the base station. receiving, at a media access control, MAC, entity from a radio resource control, RRC, entity in a communications apparatus, a first RRC message including to-be-transmitted data; determining, at the MAC entity, a coverage level of the communications apparatus according to a measured RSRP; determining, at the MAC entity, according to a data amount control threshold corresponding to the coverage level, that a data amount supported by the coverage level does not meet a size of the first RRC message, wherein the data amount control threshold is preset by a base station; sending, at the MAC entity to the RRC entity, indication information, wherein the indication information indicates that the to-be-transmitted data are not transmitted in a random access procedure; receiving, at the MAC entity, a second RRC message from the RRC entity, wherein the second RRC message does not include the to-be-transmitted data; sending, at the MAC entity according to the second RRC message, a random access preamble to the base station; and receiving, at the MAC entity, a random access response from the base station.
Spinal repositioning instrument comprising a first coupling body adapted for direct or indirect coupling to a pedicle screw , and a second coupling body adapted for direct or indirect coupling to another pedicle screw , wherein the spinal repositioning instrument is configured to perform a first movement for vertebral repositioning under which first movement the first and second coupling bodies are moved respectively for changing a distance between the pedicle screws when being coupled to the coupling bodies and to perform a second movement for reduction independent from the first movement, under which second movement the coupling bodies are moved respectively for changing the angle between the longitudinal axes of the pedicle screws when being coupled to the coupling bodies , the spinal repositioning instrument comprises a synchronising mechanism or transmission functionally linking the two coupling bodies with each other and being configured such that at least or exclusively the respective movements of the coupling bodies under the second movement are reflectionally symmetric to each other, and an adjustable linkage mechanism is provided connecting the two coupling bodies such that under the first movement the coupling bodies perform a scissor-like pivoting about a first axis (A1) provided by the linkage mechanism in a first adjustment state of the linkage mechanism exclusively allowing the pivoting movement and under the second movement the coupling bodies perform a rotation in opposite directions about respective second axes (A2) in a second adjustment state of the linkage mechanism allowing a translation movement of the coupling bodies relative to each other wherein the two second axes (A2) are relatively fixed to each other under the second movement.
An antenna assembly , comprising: a near-field-communication (NFC) integrated-circuit (IC) , comprising a first differential signal port and a second differential signal port , the first differential signal port and the second differential signal port being configured to provide a differential excitation current; a conductive loop, configured to transmit the differential excitation current and comprising: a ground plane , comprising: a first ground portion ; a second ground portion spaced apart from the first ground portion ; and a conductive path defined between the first ground portion and the second ground portion ; a first metal stub , extending from the first ground portion and electrically connected to the first differential signal port ; and a conductor , spaced apart from the ground plane , and electrically connected to the second differential signal port and the second ground portion , respectively; a radiation-field enhancer , disposed between the conductor and the ground plane and configured to enhance a field strength of an NFC radiation-field generated by the conductor in response to the differential excitation current being transmitted. a near-field-communication (NFC) integrated-circuit (IC) , comprising a first differential signal port and a second differential signal port , the first differential signal port and the second differential signal port being configured to provide a differential excitation current; a conductive loop, configured to transmit the differential excitation current and comprising: a ground plane , comprising: a first ground portion ; a second ground portion spaced apart from the first ground portion ; and a conductive path defined between the first ground portion and the second ground portion ; a first metal stub , extending from the first ground portion and electrically connected to the first differential signal port ; and a conductor , spaced apart from the ground plane , and electrically connected to the second differential signal port and the second ground portion , respectively; a ground plane , comprising: a first ground portion ; a second ground portion spaced apart from the first ground portion ; and a conductive path defined between the first ground portion and the second ground portion ; a first ground portion ; a second ground portion spaced apart from the first ground portion ; and a conductive path defined between the first ground portion and the second ground portion ; a first metal stub , extending from the first ground portion and electrically connected to the first differential signal port ; and a conductor , spaced apart from the ground plane , and electrically connected to the second differential signal port and the second ground portion , respectively; a radiation-field enhancer , disposed between the conductor and the ground plane and configured to enhance a field strength of an NFC radiation-field generated by the conductor in response to the differential excitation current being transmitted.
A method for coating a component , comprising: disposing the component with metal alloy gravel comprising aluminum; heating the metal alloy gravel adjacent the component to a temperature between 1400 degrees Fahrenheit and 1600 degrees Fahrenheit (760 degrees Celsius and 871 degrees Celsius); and forming an aluminide coating on the component , wherein the aluminum from the metal alloy gravel diffuses into the component to form the aluminide coating , characterised in that the metal alloy gravel has an average particle size of at least 0.125 inches (3.18 mm). disposing the component with metal alloy gravel comprising aluminum; heating the metal alloy gravel adjacent the component to a temperature between 1400 degrees Fahrenheit and 1600 degrees Fahrenheit (760 degrees Celsius and 871 degrees Celsius); and forming an aluminide coating on the component , wherein the aluminum from the metal alloy gravel diffuses into the component to form the aluminide coating , characterised in that the metal alloy gravel has an average particle size of at least 0.125 inches (3.18 mm).
A self-aligning busbar assembly , comprising: a housing ; a busbar having a first terminal connecting end , a second terminal connecting end , and a jog portion ) disposed therebetween; and a front holder coupled to the housing and the busbar, the front holder including an inner wall defining a busbar receiving aperture to receive at least a portion of the busbar , and at least one flexible tab extending inwardly from the inner wall into the busbar receiving aperture , the at least one flexible tab configured to bias and center the at least a portion of the busbar within the busbar receiving aperture, wherein at least one clearance is defined in the busbar receiving aperture between the inner wall and the busbar, the at least one clearance configured to enable at least one of the first and second terminal connecting ends to move to account for tolerances and/or variances during installation of the busbar assembly, characterized in that the busbar receiving aperture includes a receiving shoulder formed therein, in that the busbar includes at least one angular retention feature configured to seat with and engage the receiving shoulder to prevent removal of the front holder from the busbar ; and in that the front holder further includes a front holder aperture configured to receive a retention tab of the housing to thereby secure the front holder to the housing . a housing ; a busbar having a first terminal connecting end , a second terminal connecting end , and a jog portion ) disposed therebetween; and a front holder coupled to the housing and the busbar, the front holder including an inner wall defining a busbar receiving aperture to receive at least a portion of the busbar , and at least one flexible tab extending inwardly from the inner wall into the busbar receiving aperture , the at least one flexible tab configured to bias and center the at least a portion of the busbar within the busbar receiving aperture, wherein at least one clearance is defined in the busbar receiving aperture between the inner wall and the busbar, the at least one clearance configured to enable at least one of the first and second terminal connecting ends to move to account for tolerances and/or variances during installation of the busbar assembly, characterized in that the busbar receiving aperture includes a receiving shoulder formed therein, in that the busbar includes at least one angular retention feature configured to seat with and engage the receiving shoulder to prevent removal of the front holder from the busbar ; and in that the front holder further includes a front holder aperture configured to receive a retention tab of the housing to thereby secure the front holder to the housing .
A pole, in particular a Nordic walking pole, trekking pole, ski pole, cross-country ski pole or walking pole, comprising a pole body on the lower free end of which a tip body is provided, characterized in that the tip body comprises - a downwardly closed end attachment with a central receiving opening for receiving an insertion element which is received and fastened by way of an upper axial portion in a lowermost tube portion of the pole body , and is received by way of a lower axial portion in the central receiving opening of the end attachment , wherein the upper and/or the lower axial portion of the insertion element is cylindrical; - and an outer circumferential elastic elastomer spring element which connects axially above an upper end of the end attachment and engages around the lowermost tube portion of the pole body or a middle axial portion of the insertion element at least in part in the circumferential direction (U), and which damps an axial relative movement (R) of the lowermost tube portion of the pole body and/or of the insertion element relative to the end attachment whilst an axial force (K) is applied; wherein the the insertion element , is mounted so as to be displaceable axially in the central receiving opening of the end attachment counter a spring force of the elastic element . - a downwardly closed end attachment with a central receiving opening for receiving an insertion element which is received and fastened by way of an upper axial portion in a lowermost tube portion of the pole body , and is received by way of a lower axial portion in the central receiving opening of the end attachment , wherein the upper and/or the lower axial portion of the insertion element is cylindrical; - and an outer circumferential elastic elastomer spring element which connects axially above an upper end of the end attachment and engages around the lowermost tube portion of the pole body or a middle axial portion of the insertion element at least in part in the circumferential direction (U),
A processing system (SYS) comprising: a support apparatus that supports an object (W) at a supporting surface; a processing apparatus that is arranged at a distance from the supporting surface in a first direction (Z) and that performs an additive processing on the object by supplying powdery materials (M) to the object; a driving power source that electrically generates a driving power; the processing system being characterised by : a driving power transmission member that transmits the driving power to at least one of the support apparatus and the processing apparatus so as to change a positional relationship between the supporting surface and the processing apparatus in a second direction (X, Y) perpendicular to the first direction; a partition member that is disposed between the driving power source and at least a part of the processing apparatus and that has a formed through hole which the driving power transmission penetrates; and a seal member that seals between the driving power transmission member and the partition member. a support apparatus that supports an object (W) at a supporting surface; a processing apparatus that is arranged at a distance from the supporting surface in a first direction (Z) and that performs an additive processing on the object by supplying powdery materials (M) to the object; a driving power source that electrically generates a driving power; a driving power transmission member that transmits the driving power to at least one of the support apparatus and the processing apparatus so as to change a positional relationship between the supporting surface and the processing apparatus in a second direction (X, Y) perpendicular to the first direction; a partition member that is disposed between the driving power source and at least a part of the processing apparatus and that has a formed through hole which the driving power transmission penetrates; and a seal member that seals between the driving power transmission member and the partition member.
Method for producing a feature in a multilayer element, wherein - a base layer provided with a laser-sensitive substance (18; 32) that is modifiable with respect to the colour thereof by means of laser radiation (20; 34, 38) is provided, - an opaque layer is arranged on the base layer provided, and - laser radiation (20; 34, 38) is radiated onto the opaque layer such that thereby the opaque layer (20; 34, 38) is removed in a pattern , wherein a parameter of the irradiation using the laser radiation (20; 34, 38) is varied within the pattern such that the modification of the laser-sensitive substance (18; 32) within the pattern is varied and consequently coloured structuring (26, 28; 40, 42, 44) is produced, wherein the coloured structuring (26, 28; 40, 42, 44) comprises a first region (26; 40, 42, 44) and a peripheral region , wherein the peripheral region of the coloured structuring (26, 28; 40, 42, 44) has a single-colour embodiment, characterized in that the first region (26; 40, 42, 44) is a motif region in which the laser-sensitive substance (18; 32) is modified differently in a plurality of colours and/or in a plurality of brightness values. - a base layer provided with a laser-sensitive substance (18; 32) that is modifiable with respect to the colour thereof by means of laser radiation (20; 34, 38) is provided, - an opaque layer is arranged on the base layer provided, and - laser radiation (20; 34, 38) is radiated onto the opaque layer such that thereby the opaque layer (20; 34, 38) is removed in a pattern ,
A socket element for receiving a housing module of a self-service machine in a load-bearing manner, the socket element comprising: a support frame , with a cover section and shell sections formed on all sides on an outer edge of the cover section , wherein the cover section has a receiving surface for receiving the housing module and the shell sections of the receiving surface are arranged on the cover section opposite to the receiving surface ; at least three adjusting feet , which are arranged on a bottom side of the support frame and serve to level the support frame , wherein a support head of the adjusting feet is formed to rest on the ground ; a screen , which is designed to ensure that the socket element is as flush as possible with the ground , wherein the screen is arranged on an inner side of the support frame and is displaceable relative to the support frame between an upper operational position and a lower operational position , characterized in that at least one fixing element for fixing the screen is formed on the support frame , wherein a slot-like recess , in which the fixing element engages, is formed in the screen . a support frame , with a cover section and shell sections formed on all sides on an outer edge of the cover section , wherein the cover section has a receiving surface for receiving the housing module and the shell sections of the receiving surface are arranged on the cover section opposite to the receiving surface ; at least three adjusting feet , which are arranged on a bottom side of the support frame and serve to level the support frame , wherein a support head of the adjusting feet is formed to rest on the ground ; a screen , which is designed to ensure that the socket element is as flush as possible with the ground , wherein the screen is arranged on an inner side of the support frame and is displaceable relative to the support frame between an upper operational position and a lower operational position , characterized in that at least one fixing element for fixing the screen is formed on the support frame , wherein a slot-like recess , in which the fixing element engages, is formed in the screen .