mhurhangee/patent-ind-claim-en huggingface dataset:
A method for modifying a target genomic locus in a mammalian cell, comprising: (a) introducing into the cell a nuclease agent that makes a single or double-strand break within the target genomic locus; (b) introducing into the cell a first large targeting vector (LTVEC) that is at least 10 kb in length and comprises a first nucleic acid insert flanked by a first 5' homology arm and a first 3' homology arm, and a second LTVEC that is at least 10 kb in length and comprises a second nucleic acid insert flanked by a second 5' homology arm and a second 3' homology arm, wherein the combined size of the first nucleic acid insert and the second nucleic acid insert is at least 100 kb, wherein the first 3' homology arm of the first LTVEC has a first overlapping sequence homologous to the second 5' homology arm of the second LTVEC, and the first 5' homology arm of the first LTVEC and the second 3' homology arm of the second LTVEC are homologous to corresponding genomic segments within the target genomic locus, wherein the first overlapping sequence is at least 1 kb, and wherein the target genomic locus is modified by integration of the first nucleic acid insert and the second nucleic acid insert between the corresponding genomic segments; and (c) selecting a targeted cell comprising the first nucleic acid insert and the second nucleic acid insert integrated into the target genomic locus. (a) introducing into the cell a nuclease agent that makes a single or double-strand break within the target genomic locus; (b) introducing into the cell a first large targeting vector (LTVEC) that is at least 10 kb in length and comprises a first nucleic acid insert flanked by a first 5' homology arm and a first 3' homology arm, and a second LTVEC that is at least 10 kb in length and comprises a second nucleic acid insert flanked by a second 5' homology arm and a second 3' homology arm, wherein the combined size of the first nucleic acid insert and the second nucleic acid insert is at least 100 kb, wherein the first 3' homology arm of the first LTVEC has a first overlapping sequence homologous to the second 5' homology arm of the second LTVEC, and the first 5' homology arm of the first LTVEC and the second 3' homology arm of the second LTVEC are homologous to corresponding genomic segments within the target genomic locus, wherein the first overlapping sequence is at least 1 kb, and wherein the target genomic locus is modified by integration of the first nucleic acid insert and the second nucleic acid insert between the corresponding genomic segments; and (c) selecting a targeted cell comprising the first nucleic acid insert and the second nucleic acid insert integrated into the target genomic locus.
A granular material having a mean particle diameter of 150 to 350 micrometers and a compactibility resulting in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa, at least 60 % of the granular material being a water-soluble hydroxypropyl methyl cellulose having a hydroxypropoxyl substitution of 4 to 12 percent and a methoxyl substitution of 19 to 30 percent, based on the total weight of the granular material, which is obtained by subjecting the cellulose derivative in powder form to a granulation step.
A head worn imaging system, comprising: a light source configured to generate a light beam; a single light guiding optical element comprising an entry portion and an exit portion , wherein the single light guiding optical element is configured to propagate at least a portion of the light beam by total internal reflection; and characterized in that the single light guiding optical element has a light guiding optical element geometry; a thickness of between 0.1 and 1.5 mm; and a plurality of multiplexed volume holograms formed therein, each of the plurality of multiplexed volume holograms corresponding to a respective modulation of the index of refraction the exit portion of the single light guiding optical element is configured to selectively allow light addressing the exit portion to exit the light guiding optical element based on one or more characteristics of the light, wherein the one or more characteristics comprises an angle of incidence of the light and a radius of the curvature of the light; and the single light guiding optical element multiplexing depth planes of output light by controlling the angle of incidence and the radius of curvature of the light with the plurality of multiplexed volume holograms and the light guiding optical element geometry. a light source configured to generate a light beam; a single light guiding optical element comprising an entry portion and an exit portion , wherein the single light guiding optical element is configured to propagate at least a portion of the light beam by total internal reflection; and characterized in that the single light guiding optical element has a light guiding optical element geometry; a thickness of between 0.1 and 1.5 mm; and a plurality of multiplexed volume holograms formed therein, each of the plurality of multiplexed volume holograms corresponding to a respective modulation of the index of refraction a light guiding optical element geometry; a thickness of between 0.1 and 1.5 mm; and a plurality of multiplexed volume holograms formed therein, each of the plurality of multiplexed volume holograms corresponding to a respective modulation of the index of refraction the exit portion of the single light guiding optical element is configured to selectively allow light addressing the exit portion to exit the light guiding optical element based on one or more characteristics of the light, wherein the one or more characteristics comprises an angle of incidence of the light and a radius of the curvature of the light; and the single light guiding optical element multiplexing depth planes of output light by controlling the angle of incidence and the radius of curvature of the light with the plurality of multiplexed volume holograms and the light guiding optical element geometry.
A liquid dosing apparatus for dispensing a liquid from a container into a liquid stream of a shower, toilet or tap, the apparatus comprising: an adapter arranged to detachably receive the container ; a dosing mechanism comprising a dosing chamber and a moveable member , and arranged to draw a set volume of the liquid into the dosing chamber on activation, activation comprising moving the moveable member in a first direction; a damping control system arranged to control a dispensing rate of the set volume of the liquid by controlling return speed of the moveable member ; and a dispensing outlet arranged to dispense the liquid into the water stream at the controlled dispensing rate. an adapter arranged to detachably receive the container ; a dosing mechanism comprising a dosing chamber and a moveable member , and arranged to draw a set volume of the liquid into the dosing chamber on activation, activation comprising moving the moveable member in a first direction; a damping control system arranged to control a dispensing rate of the set volume of the liquid by controlling return speed of the moveable member ; and a dispensing outlet arranged to dispense the liquid into the water stream at the controlled dispensing rate.
An external-internal self-centering valve adapter connection assembly comprising: a first equipment flange ; a second equipment flange ; an adapter ring , and a gasket disposed between the first equipment flange and the adapter ring , wherein the adapter ring includes an annular ring having an inner surface and an outer surface , a first flange extending longitudinally away from the annular ring proximate the inner surface and a second flange extending longitudinally away from the annular ring proximate the outer surface ; wherein the first flange and the second flange extend in opposite directions; and wherein the first flange includes an inner tapered surface and an outer cylindrical surface and extends into the first equipment flange such that the outer cylindrical surface of the first flange is disposed adjacent to an inner cylindrical surface of the first equipment flange . a first equipment flange ; a second equipment flange ; an adapter ring , and a gasket disposed between the first equipment flange and the adapter ring , wherein the adapter ring includes an annular ring having an inner surface and an outer surface , a first flange extending longitudinally away from the annular ring proximate the inner surface and a second flange extending longitudinally away from the annular ring proximate the outer surface ; wherein the first flange and the second flange extend in opposite directions; and wherein the first flange includes an inner tapered surface and an outer cylindrical surface and extends into the first equipment flange such that the outer cylindrical surface of the first flange is disposed adjacent to an inner cylindrical surface of the first equipment flange .
Biopsy container assembly comprising: - a container with a lower chamber (C1) suitable for containing a buffer liquid (L1), - a cap coupled with said container ; said cap being provided with a chamber (C3) that contains a biopsy liquid (L2) sealed by means of a membrane , and - a crown with a toothing suitable for tearing off said membrane of the cap; characterized in that said crown is suitable for being disposed in the container in an initial position, wherein the toothing is directed downwards in order not to interfere with the membrane of the cap when the cap is closed on the container, and in an operating position, wherein the toothing is directed upwards in order to tear off the membrane of the cap when the cap is closed on the container. - a container with a lower chamber (C1) suitable for containing a buffer liquid (L1), - a cap coupled with said container ; said cap being provided with a chamber (C3) that contains a biopsy liquid (L2) sealed by means of a membrane , and - a crown with a toothing suitable for tearing off said membrane of the cap; characterized in that said crown is suitable for being disposed in the container in an initial position, wherein the toothing is directed downwards in order not to interfere with the membrane of the cap when the cap is closed on the container, and in an operating position, wherein the toothing is directed upwards in order to tear off the membrane of the cap when the cap is closed on the container.
A method for monitoring, preferably continuously monitoring, the membrane coupling in a pressure measurement system in an extracorporeal circuit of a blood treatment machine comprising the steps: - detecting periodic pressure pulses occurring in the extracorporeal circuit; - a frequency analysis based on the detected periodic pressure pulses for calculating at least one Fourier coefficient; - comparing the at least one calculated Fourier coefficient with respect to its intensity with at least one associated reference value; and - outputting a signal when the comparison shows that, with respect to its intensity, the at least one Fourier coefficient differs from the associated reference value beyond a predetermined tolerance threshold value. - detecting periodic pressure pulses occurring in the extracorporeal circuit; - a frequency analysis based on the detected periodic pressure pulses for calculating at least one Fourier coefficient; - comparing the at least one calculated Fourier coefficient with respect to its intensity with at least one associated reference value; and - outputting a signal when the comparison shows that, with respect to its intensity, the at least one Fourier coefficient differs from the associated reference value beyond a predetermined tolerance threshold value.
A weed grinder , characterized by comprising: a single board , comprising at least four panels (14A, 14C, 14E, 14F, 114A, 114C, 114E, 114F,); at least one folding line disposed between adjacent panels of said at least four panels, for forming a closed flat cell between two of said adjacent panels (14C 14F, 114C, 114F); and two grinding plates , each grinding plate disposed on each of said two of said adjacent panels , wherein at least one of said two grinding plates is movable in linear motion with respect to the other . a single board , comprising at least four panels (14A, 14C, 14E, 14F, 114A, 114C, 114E, 114F,); at least one folding line disposed between adjacent panels of said at least four panels, for forming a closed flat cell between two of said adjacent panels (14C 14F, 114C, 114F); and two grinding plates , each grinding plate disposed on each of said two of said adjacent panels , wherein at least one of said two grinding plates is movable in linear motion with respect to the other .
A dry-powder inhaler comprising a casing , the casing comprising: a first casing portion comprising a first end and a second end ; a second casing portion comprising a corresponding first end and a corresponding second end ; a hinge arrangement connecting said first casing portion and second casing portion ; whereby the second end of the first casing portion and the second end of the second casing portion are connected by means of the hinge arrangement to form an outlet ; whereby the dry-powder inhaler is assembled by means of folding the first casing portion and the second casing portion together; whereby the first casing portion comprises a cavity for receiving a lidding foil , said cavity being adapted to contain a dry-powder medicament; and whereby the first casing portion and second casing portion when folded together are adapted to form an inlet for allowing the lidding foil extending out there from and the outlet for providing the medicament. a first casing portion comprising a first end and a second end ; a second casing portion comprising a corresponding first end and a corresponding second end ; a hinge arrangement connecting said first casing portion and second casing portion ; whereby the second end of the first casing portion and the second end of the second casing portion are connected by means of the hinge arrangement to form an outlet ; whereby the dry-powder inhaler is assembled by means of folding the first casing portion and the second casing portion together; whereby the first casing portion comprises a cavity for receiving a lidding foil , said cavity being adapted to contain a dry-powder medicament; and whereby the first casing portion and second casing portion when folded together are adapted to form an inlet for allowing the lidding foil extending out there from and the outlet for providing the medicament.
A method of secure data transfer in a communication system, the method comprising: connecting a wireless device to a sink device via at least a first wireless link; connecting the sink device to a gateway of a cellular network via at least a second wireless link, wherein the second wireless link is a cellular link; and establishing a security tunnel between the wireless device and the gateway of the cellular network through at least the sink device, wherein the wireless device is in communication with a core network via at least the sink device and the gateway of the cellular network, and wherein the gateway of the cellular network is external to the core network. connecting a wireless device to a sink device via at least a first wireless link; connecting the sink device to a gateway of a cellular network via at least a second wireless link, wherein the second wireless link is a cellular link; and establishing a security tunnel between the wireless device and the gateway of the cellular network through at least the sink device, wherein the wireless device is in communication with a core network via at least the sink device and the gateway of the cellular network, and wherein the gateway of the cellular network is external to the core network.
A control architecture for electrified braking and electrified steering of a vehicle, the control architecture comprising: - at least two energy supply units ; - a steering actuator ; - a steering controller ; and - two brake actuator units ; wherein, the steering actuator and steering controller are configured to be supplied with power from a first one of the at least two energy supply units; wherein the two brake actuators are configured to be supplied with power from a second one of the at least two energy supply units; wherein a first brake actuator is associated with a first wheel of the vehicle and a second brake actuator is associated with a second wheel of the vehicle ; and wherein, actuation of the first brake actuator and the second brake actuator is configured to perform a steering function for the vehicle, characterised in that the first brake actuator and second brake actuator are associated with the two wheels of a same axle of the vehicle. - at least two energy supply units ; - a steering actuator ; - a steering controller ; and - two brake actuator units ; wherein, the steering actuator and steering controller are configured to be supplied with power from a first one of the at least two energy supply units; wherein the two brake actuators are configured to be supplied with power from a second one of the at least two energy supply units; wherein a first brake actuator is associated with a first wheel of the vehicle and a second brake actuator is associated with a second wheel of the vehicle ; and wherein, actuation of the first brake actuator and the second brake actuator is configured to perform a steering function for the vehicle, characterised in that the first brake actuator and second brake actuator are associated with the two wheels of a same axle of the vehicle. wherein, the steering actuator and steering controller are configured to be supplied with power from a first one of the at least two energy supply units; wherein the two brake actuators are configured to be supplied with power from a second one of the at least two energy supply units; wherein a first brake actuator is associated with a first wheel of the vehicle and a second brake actuator is associated with a second wheel of the vehicle ; and wherein, actuation of the first brake actuator and the second brake actuator is configured to perform a steering function for the vehicle, characterised in that the first brake actuator and second brake actuator are associated with the two wheels of a same axle of the vehicle.
A light control sheet comprising: a first transparent electrode ; a second transparent electrode ; a liquid crystal layer disposed between the first transparent electrode and the second transparent electrode ; and a plurality of spacers (SP1, SP2) disposed in the liquid crystal layer , wherein the spacers (SP1, SP2) have an average size of 3 μm or more and 50 μm or less, and the spacers (SP1, SP2) have a size distribution having two or more discrete peaks, characterized in that the two or more discrete peaks include a first peak, the first peak being a peak having a mode having a largest size among the discrete peaks, and the mode in the size distribution of the first peak is 8 μm or more and 50 μm or less, and the two or more discrete peaks include a second peak, the second peak being a peak having a mode having a second largest size among the discrete peaks, and the mode in the size distribution of the second peak is 3 μm or more and 7 μm or less. a first transparent electrode ; a second transparent electrode ; a liquid crystal layer disposed between the first transparent electrode and the second transparent electrode ; and a plurality of spacers (SP1, SP2) disposed in the liquid crystal layer , wherein the spacers (SP1, SP2) have an average size of 3 μm or more and 50 μm or less, and the spacers (SP1, SP2) have a size distribution having two or more discrete peaks, the two or more discrete peaks include a first peak, the first peak being a peak having a mode having a largest size among the discrete peaks, and the mode in the size distribution of the first peak is 8 μm or more and 50 μm or less, and the two or more discrete peaks include a second peak, the second peak being a peak having a mode having a second largest size among the discrete peaks, and the mode in the size distribution of the second peak is 3 μm or more and 7 μm or less.
A flexible display apparatus comprising: a flexible display ; a sensor ; and a processor configured to: control the flexible display to display an execution screen of a first application on the entire flexible display ; based on a message corresponding to a second application being received, display a notice message related to receiving the message on a region of the execution screen; and based on the sensor sensing a first bending in the region of the execution screen on which the notice message is displayed, control the flexible display to display the whole text of the received message on the region of the flexible display on which the first bending is sensed and to maintain display of the execution screen of the first application on the remainder region outside the region on which the first bending is sensed. a flexible display ; a sensor ; and a processor configured to: control the flexible display to display an execution screen of a first application on the entire flexible display ; based on a message corresponding to a second application being received, display a notice message related to receiving the message on a region of the execution screen; and based on the sensor sensing a first bending in the region of the execution screen on which the notice message is displayed, control the flexible display to display the whole text of the received message on the region of the flexible display on which the first bending is sensed and to maintain display of the execution screen of the first application on the remainder region outside the region on which the first bending is sensed. control the flexible display to display an execution screen of a first application on the entire flexible display ; based on a message corresponding to a second application being received, display a notice message related to receiving the message on a region of the execution screen; and based on the sensor sensing a first bending in the region of the execution screen on which the notice message is displayed, control the flexible display to display the whole text of the received message on the region of the flexible display on which the first bending is sensed and to maintain display of the execution screen of the first application on the remainder region outside the region on which the first bending is sensed.
A heat sink, comprising: a body of solid-phase material defining at least one contact face adapted for direct contact with a heat source requiring cooling, characterized in that the body of solid-phase gallium has a plurality of sealed cavities defined therein; and said heat sink further comprises an unencapsulated phase change material disposed in the cavities ; wherein the unencapsulated phase change material absorbs heat from the solid-phase elemental gallium , maintaining viability of the heat sink, characterized in that said body of solid-phase material is elemental gallium and in that the unencapsulated phase change material has a higher specific heat capacity that gallium. a body of solid-phase material defining at least one contact face adapted for direct contact with a heat source requiring cooling, characterized in that the body of solid-phase gallium has a plurality of sealed cavities defined therein; and said heat sink further comprises an unencapsulated phase change material disposed in the cavities ; wherein the unencapsulated phase change material absorbs heat from the solid-phase elemental gallium , maintaining viability of the heat sink, characterized in that said body of solid-phase material is elemental gallium and in that the unencapsulated phase change material has a higher specific heat capacity that gallium.