Device for vacuum and vent tube stoppering a medical container , comprising: - a main body defining an internal volume that comprises a first variable pressure chamber configured to be connected to a vacuum pump , the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber and, - a vent device comprising a vent tube moveable inside the internal volume of the main body along a longitudinal axis (A) between a proximal rest position and a distal operative position wherein the vent tube passes through the first variable pressure chamber down to the inside of the medical container , the vent tube having an internal volume configured to contain a stopper in a compressed state, the vent tube being in communication with a second variable pressure chamber configured to be connected to the vacuum pump , - a piston rod moveable inside the internal volume of the vent tube along the longitudinal axis (A) between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container when the vent tube is in the operative position, - a container holder system provided in the main body , in communication with the first variable pressure chamber , said container holder system being configured to receive the proximal end of a medical container to be stoppered and to hold the medical container aligned with the direction of travel of the vent tube so that when moving from the proximal rest position to the distal operative position, the vent tube enters the medical container . - a main body defining an internal volume that comprises a first variable pressure chamber configured to be connected to a vacuum pump , the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber and, - a vent device comprising a vent tube moveable inside the internal volume of the main body along a longitudinal axis (A) between a proximal rest position and a distal operative position wherein the vent tube passes through the first variable pressure chamber down to the inside of the medical container , the vent tube having an internal volume configured to contain a stopper in a compressed state, the vent tube being in communication with a second variable pressure chamber configured to be connected to the vacuum pump , - a piston rod moveable inside the internal volume of the vent tube along the longitudinal axis (A) between a proximal rest position and a distal operative position wherein the piston rod pushes the stopper into the medical container when the vent tube is in the operative position, - a container holder system provided in the main body , in communication with the first variable pressure chamber , said container holder system being configured to receive the proximal end of a medical container to be stoppered and to hold the medical container aligned with the direction of travel of the vent tube so that when moving from the proximal rest position to the distal operative position, the vent tube enters the medical container . <EOS>