A compound of structure 15, 16 or 17: Where m is 1, 2 or 3; n is 1 or 2; o is 1 or 2; p is 0, 1, 2 or 3; R 2 is selected from a group consisting of -H or -CH 3 ; X is -OH, -NH 2 , -SH, -OR 11 , -NHR 12 , -NR 13 R 14 , -OC(O)R 15 , -NHC(O)R 16 , -SC(O)R 17 , -C(O)OH, -C(O)OR 18 , -C(O)NHR 19 , -C(O)NR 20 R 21 , -N 3 ; R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 and R 21 are independently selected from (C 1 -C 8 )alkyl, (C 1 -C 8 )substituted alkyl, -CH 2 CH(OH)CH 2 (OH), -CH(CH 2 OH) 2 , -CH 2 CCH, - (CH 2 CH 2 O) a -CH 2 CH 2 OH where a is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -P(NR 22 R 23 )OCH 2 CH 2 -EWG, -P(O)(O - )-Oligonucleotide, -(CH 2 ) b CC-Nucleoside, -(CH 2 ) b CC-[Nucleoside Triphosphate], -(CH 2 ) b -Nucleoside, -(CH 2 ) b -[Nucleoside Triphosphate], -(CH 2 ) b NH-Nucleoside, -(CH 2 ) b NH-[Nucleoside Triphosphate], -(CH 2 ) b NHC(O)(CH 2 ) b -Nucleoside, - (CH 2 ) b NHC(O)(CH 2 ) b -[Nucleoside Triphosphate], where b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; EWG is an electron withdrawing group; R 22 and R 23 are independently selected from -CH 3 , -CH 2 CH 3 , -CH(CH 3 ) 2 or R 22 and R 23 together form a heterocycle; and in the compound of structure 15, R x and R y are independently H or CH 3 ; in the compound of structure 16, R 7 and R 8 are independently selected from H, (Ci-C 8 )alkyl, (C 1 -C 8 )substituted alkyl, or R 7 and R 8 together form a five-, six-, or seven-membered heterocycle; and in the compound of structure 17, R 24 is (C 1 -C 8 )alkyl or (C 1 -C 8 )substituted alkyl; R 25 is (C 1 -C 8 )alkyl, (C 1 -C 8 )substituted alkyl or CH 2 SO 3 H; and the dashed line represents an optional double bond. m is 1, 2 or 3; n is 1 or 2; o is 1 or 2; p is 0, 1, 2 or 3; R 2 is selected from a group consisting of -H or -CH 3 ; X is -OH, -NH 2 , -SH, -OR 11 , -NHR 12 , -NR 13 R 14 , -OC(O)R 15 , -NHC(O)R 16 , -SC(O)R 17 , -C(O)OH, -C(O)OR 18 , -C(O)NHR 19 , -C(O)NR 20 R 21 , -N 3 ; R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 and R 21 are independently selected from (C 1 -C 8 )alkyl, (C 1 -C 8 )substituted alkyl, -CH 2 CH(OH)CH 2 (OH), -CH(CH 2 OH) 2 , -CH 2 CCH, - (CH 2 CH 2 O) a -CH 2 CH 2 OH where a is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, -P(NR 22 R 23 )OCH 2 CH 2 -EWG, -P(O)(O - )-Oligonucleotide, -(CH 2 ) b CC-Nucleoside, -(CH 2 ) b CC-[Nucleoside Triphosphate], -(CH 2 ) b -Nucleoside, -(CH 2 ) b -[Nucleoside Triphosphate], -(CH 2 ) b NH-Nucleoside, -(CH 2 ) b NH-[Nucleoside Triphosphate], -(CH 2 ) b NHC(O)(CH 2 ) b -Nucleoside, - (CH 2 ) b NHC(O)(CH 2 ) b -[Nucleoside Triphosphate], where b is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; EWG is an electron withdrawing group; R 22 and R 23 are independently selected from -CH 3 , -CH 2 CH 3 , -CH(CH 3 ) 2 or R 22 and R 23 together form a heterocycle; and in the compound of structure 15, R x and R y are independently H or CH 3 ; in the compound of structure 16, R 7 and R 8 are independently selected from H, (Ci-C 8 )alkyl, (C 1 -C 8 )substituted alkyl, or R 7 and R 8 together form a five-, six-, or seven-membered heterocycle; and in the compound of structure 17, R 24 is (C 1 -C 8 )alkyl or (C 1 -C 8 )substituted alkyl; R 25 is (C 1 -C 8 )alkyl, (C 1 -C 8 )substituted alkyl or CH 2 SO 3 H; and the dashed line represents an optional double bond. <EOS>