mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody-drug conjugate of Formula (I): Ab-(L-D) p (I) wherein (i) Ab is an internalizing anti-folate receptor alpha antibody or internalizing antigen-binding fragment thereof comprising three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:2 (HCDR1), SEQ ID NO:3 (HCDR2), and SEQ ID NO:4 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:7 (LCDR1), SEQ ID NO:8 (LCDR2), and SEQ ID NO:9 (LCDR3), as defined by the Kabat numbering system; or three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:13 (HCDR1), SEQ ID NO:14 (HCDR2), and SEQ ID NO:15 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:16 (LCDR1), SEQ ID NO:17 (LCDR2), and SEQ ID NO:18 (LCDR3), as defined by the IMGT numbering system; (ii) D is eribulin; (iii) L is a cleavable linker comprising Mal-(PEG) 2 -Val-Cit-pAB; and (iv) p is an integer from 1 to 8. (i) Ab is an internalizing anti-folate receptor alpha antibody or internalizing antigen-binding fragment thereof comprising three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:2 (HCDR1), SEQ ID NO:3 (HCDR2), and SEQ ID NO:4 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:7 (LCDR1), SEQ ID NO:8 (LCDR2), and SEQ ID NO:9 (LCDR3), as defined by the Kabat numbering system; or three heavy chain complementarity determining regions (HCDRs) comprising amino acid sequences of SEQ ID NO:13 (HCDR1), SEQ ID NO:14 (HCDR2), and SEQ ID NO:15 (HCDR3); and three light chain complementarity determining regions (LCDRs) comprising amino acid sequences of SEQ ID NO:16 (LCDR1), SEQ ID NO:17 (LCDR2), and SEQ ID NO:18 (LCDR3), as defined by the IMGT numbering system; (ii) D is eribulin; (iii) L is a cleavable linker comprising Mal-(PEG) 2 -Val-Cit-pAB; and (iv) p is an integer from 1 to 8.
A method of automatically cleaning a powder coating production line comprising a first device and a second device, the first device comprising an extruder , and the second device comprising a tablet machine , a mill , a cyclone separator , a sieve , and/or a negative pressure pipeline , the method comprising: a) receiving an instruction of automatic cleaning, by the first device and the second device, and allowing the powder coating production line to enter an automatic cleaning mode; b) cleaning the first device by utilizing a first automatic cleaning tool, and cleaning the second device by utilizing a second automatic cleaning tool, wherein the first automatic cleaning tool comprises a cleaning material, and the second automatic cleaning tool comprises an automatic blowing device (350a-350c); c) monitoring, according to a preset monitoring condition and by a monitoring device, whether b) is completed; d) stopping the automatic cleaning when the monitoring device indicates b) has been completed; and e) turning off the automatic cleaning mode of the first device and the second device. a) receiving an instruction of automatic cleaning, by the first device and the second device, and allowing the powder coating production line to enter an automatic cleaning mode; b) cleaning the first device by utilizing a first automatic cleaning tool, and cleaning the second device by utilizing a second automatic cleaning tool, wherein the first automatic cleaning tool comprises a cleaning material, and the second automatic cleaning tool comprises an automatic blowing device (350a-350c); c) monitoring, according to a preset monitoring condition and by a monitoring device, whether b) is completed; d) stopping the automatic cleaning when the monitoring device indicates b) has been completed; and e) turning off the automatic cleaning mode of the first device and the second device.
A hollow spring member which is constituted of a hollow rod , and includes a terminal sealed portion at an end portion of the rod , the terminal sealed portion having a rotationally symmetric shape in which an axis (X1) passing through a center of the rod is a symmetric axis, characterized by comprising: an end wall portion including a flat end face which is substantially flat and perpendicular to the axis (X1); an arc-shaped curved surface formed between an outer peripheral surface of the rod and the flat end face , the arc-shaped curved surface connecting between the outer peripheral surface of the rod and the end face with a smooth curved surface, a distal-end-center closure portion existing on the axis (X1) at a center of the end wall portion ; and a recess formed on an inner surface of the end wall portion , and having a rotationally symmetric shape in which the axis (X1) is the symmetric axis, wherein a thickness of the recess of the end wall portion is reduced toward the axis (X1), and a center of the recess is located on the axis (X1). an end wall portion including a flat end face which is substantially flat and perpendicular to the axis (X1); an arc-shaped curved surface formed between an outer peripheral surface of the rod and the flat end face , the arc-shaped curved surface connecting between the outer peripheral surface of the rod and the end face with a smooth curved surface, a distal-end-center closure portion existing on the axis (X1) at a center of the end wall portion ; and a recess formed on an inner surface of the end wall portion , and having a rotationally symmetric shape in which the axis (X1) is the symmetric axis, wherein a thickness of the recess of the end wall portion is reduced toward the axis (X1), and a center of the recess is located on the axis (X1).
A security system comprising: an access control node broadcasting a beacon including the current time; and user devices generating replies in device broadcasts to the beacon that are based on credential information for the user of the user device and the current time, wherein the access control node is further arranged to: use the time contained in its broadcast and a NodeID of the access control node , to retrieve a security ID and a unique device ID, UDID, from a received device broadcast; use the UDID to retrieve a symmetric key and a seed key; use the retrieved symmetric key to decrypt a data store containing a Card Identifier; use the seed key of the UDID to run a Time based One Time Password algorithm to calculate a present Security ID; determine if the retrieved Security ID is correct based on the calculated present Security ID; if the retrieved Security ID is correct, the access control node determines if the user device associated with the received request has access rights for an access point associated with the access control node based on the Card Identifier; and if the user device has access rights, access to the access point is approved. an access control node broadcasting a beacon including the current time; and user devices generating replies in device broadcasts to the beacon that are based on credential information for the user of the user device and the current time, wherein the access control node is further arranged to: use the time contained in its broadcast and a NodeID of the access control node , to retrieve a security ID and a unique device ID, UDID, from a received device broadcast; use the UDID to retrieve a symmetric key and a seed key; use the retrieved symmetric key to decrypt a data store containing a Card Identifier; use the seed key of the UDID to run a Time based One Time Password algorithm to calculate a present Security ID; determine if the retrieved Security ID is correct based on the calculated present Security ID; if the retrieved Security ID is correct, the access control node determines if the user device associated with the received request has access rights for an access point associated with the access control node based on the Card Identifier; and if the user device has access rights, access to the access point is approved. use the time contained in its broadcast and a NodeID of the access control node , to retrieve a security ID and a unique device ID, UDID, from a received device broadcast; use the UDID to retrieve a symmetric key and a seed key; use the retrieved symmetric key to decrypt a data store containing a Card Identifier; use the seed key of the UDID to run a Time based One Time Password algorithm to calculate a present Security ID; determine if the retrieved Security ID is correct based on the calculated present Security ID; if the retrieved Security ID is correct, the access control node determines if the user device associated with the received request has access rights for an access point associated with the access control node based on the Card Identifier; and if the user device has access rights, access to the access point is approved.
A hydraulic density separator for separating higher density elements and lower density elements of solids material, the apparatus comprising: - a first compartment for receiving a mixture comprising higher density elements and lower density elements, and water; - a flow generator configured to provide an upward flow of water within the first compartment , the apparatus being configured such that the rate of said flow can be adjusted to allow the maximum density of elements that will be entrained by said flow and rise upwardly to be varied; - means in the first compartment for removing higher density elements that have settled from a lower region of the first compartment , - a second compartment for receiving a mixture comprising water and lower density elements from the first compartment , the second compartment comprising a mesh screen configured to move lower density elements from a first position to a second position spaced apart from the first position ; - wherein a water flow path is provided from an upper region of the first compartment into the second compartment and over a portion of the mesh screen such that lower density elements entrained by the flow of water are deposited on the mesh screen; and - wherein the upward flow of water within the first compartment provided by the flow generator is configured in such a way that elements being slightly denser than water are carried to the second compartment . - a first compartment for receiving a mixture comprising higher density elements and lower density elements, and water; - a flow generator configured to provide an upward flow of water within the first compartment , the apparatus being configured such that the rate of said flow can be adjusted to allow the maximum density of elements that will be entrained by said flow and rise upwardly to be varied; - means in the first compartment for removing higher density elements that have settled from a lower region of the first compartment , - a second compartment for receiving a mixture comprising water and lower density elements from the first compartment , the second compartment comprising a mesh screen configured to move lower density elements from a first position to a second position spaced apart from the first position ; - wherein a water flow path is provided from an upper region of the first compartment into the second compartment and over a portion of the mesh screen such that lower density elements entrained by the flow of water are deposited on the mesh screen; and - wherein the upward flow of water within the first compartment provided by the flow generator is configured in such a way that elements being slightly denser than water are carried to the second compartment .
A heart valve system , the system comprising: a radially self-expandable tubular body having an inflow end and an outflow end ; and a valve coupled to the tubular body , the valve including a plurality of valve leaflets , wherein: the valve is coupled to the outflow end of the tubular body such that the valve leaflets extend distally of the outflow end of the tubular body in an outflow direction, and the inflow end of the tubular body is connected to the outflow end of the tubular body at connection points , a number of connection points being equivalent to a number of the valve leaflets . a radially self-expandable tubular body having an inflow end and an outflow end ; and a valve coupled to the tubular body , the valve including a plurality of valve leaflets , wherein: the valve is coupled to the outflow end of the tubular body such that the valve leaflets extend distally of the outflow end of the tubular body in an outflow direction, and the inflow end of the tubular body is connected to the outflow end of the tubular body at connection points , a number of connection points being equivalent to a number of the valve leaflets . the valve is coupled to the outflow end of the tubular body such that the valve leaflets extend distally of the outflow end of the tubular body in an outflow direction, and the inflow end of the tubular body is connected to the outflow end of the tubular body at connection points , a number of connection points being equivalent to a number of the valve leaflets .
A data processing system comprising: an information input unit operable to receive information relating to computer gameplay of a computer game; an error characterising unit operable to identify indicators of an error in the computer game based upon the received information; a playtest control unit operable to control one or more playtest bots in the computer game to generate playtest data for the computer game, the playtest data comprising information relating to the identified indicators of an error, wherein the playtest control unit is operable to cause one or more playtest bots to simulate interactions performed by human players of the computer game; an error reporting unit operable to identify errors in dependence upon the playtest data, wherein the error characterising unit is operable to identify indicators of errors including one or more of computer gameplay termination, visual errors, interaction errors, and/or audio errors. an information input unit operable to receive information relating to computer gameplay of a computer game; an error characterising unit operable to identify indicators of an error in the computer game based upon the received information; a playtest control unit operable to control one or more playtest bots in the computer game to generate playtest data for the computer game, the playtest data comprising information relating to the identified indicators of an error, wherein the playtest control unit is operable to cause one or more playtest bots to simulate interactions performed by human players of the computer game; an error reporting unit operable to identify errors in dependence upon the playtest data, wherein the error characterising unit is operable to identify indicators of errors including one or more of computer gameplay termination, visual errors, interaction errors, and/or audio errors.
A briefcase comprising a retractable mechanism , characterized in that the retractable mechanism includes a frame , a retractable casing configured to occupy a retracted position in which the retractable casing is locked in the frame and a deployed position relative to the frame, and an actuator , the actuator including a cam track arranged on the retractable casing , a cam follower secured to a rocker arranged in the frame, and a pusher to bring back the retractable casing from its retracted position to its deployed position when the retractable casing is unlocked, the cam track including a locking portion in which the cam follower is arranged when the retractable casing is locked in its retracted position, such that the actuator further includes a retaining member arranged to prevent the cam follower from leaving the locking portion of the cam track as long as the force exerted on a bearing wall of the retractable casing does not exceed a predetermined threshold value so as to prevent involuntary unlocking of the retractable mechanism.
An electrode catheter comprising: a catheter shaft that has at least one lumen ; at least one ring-shaped electrode (201, 202, 203, 204, 205, 206, 207, 208, 209, 210; 72, 73, 74) that is attached to an outer circumferential surface of a distal end part of the catheter shaft ; and a lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) that is coupled to the ring-shaped electrode (201, 202, 203, 204, 205, 206, 207, 208, 209, 210; 72, 73, 74), wherein a side hole that extends from the outer circumferential surface to the lumen is formed in a tube wall of the distal end part of the catheter shaft in correspondence to an attachment position of the ring-shaped electrode , wherein the lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) is configured by coating a metal core wire with a resin, the lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) being joined at a distal end portion thereof to an inner circumferential surface of the ring-shaped electrode and thereby being coupled to said ring-shaped electrode while entering the lumen through the side hole and extending in said lumen , and wherein the catheter shaft is constituted by a braided tube that is reinforced by a braid made of a resin throughout the entire length thereof. a catheter shaft that has at least one lumen ; at least one ring-shaped electrode (201, 202, 203, 204, 205, 206, 207, 208, 209, 210; 72, 73, 74) that is attached to an outer circumferential surface of a distal end part of the catheter shaft ; and a lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) that is coupled to the ring-shaped electrode (201, 202, 203, 204, 205, 206, 207, 208, 209, 210; 72, 73, 74), wherein a side hole that extends from the outer circumferential surface to the lumen is formed in a tube wall of the distal end part of the catheter shaft in correspondence to an attachment position of the ring-shaped electrode , wherein the lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) is configured by coating a metal core wire with a resin, the lead (301, 302, 303, 304, 305, 306, 307, 308, 309, 310; 82, 83, 84) being joined at a distal end portion thereof to an inner circumferential surface of the ring-shaped electrode and thereby being coupled to said ring-shaped electrode while entering the lumen through the side hole and extending in said lumen , and wherein the catheter shaft is constituted by a braided tube that is reinforced by a braid made of a resin throughout the entire length thereof.
Tire support rim for an annular track roller comprising at least one outer ring of which a prolonged part in the form of a disk on the periphery of the outer ring produces a flange of which the end of the peripheral edge is configured to cooperate with a guiding rail, the rim comprising a substantially circular annular arrangement defining: - a peripheral edge intended to bear a tire , - a medial edge intended to be in contact with a medial outer surface of the outer ring of the roller, and - two opposite faces producing, on the one hand, an open face and, on the other hand, a bearing face configured to be positioned against the surface of the flange of the track roller, characterized in that the support rim incorporates a cooling device comprising at least one circulation duct for air passing through the thickness of the rim such that the duct comprises at least one orifice positioned on the open face of the rim and a circuit arranged such that, on the one hand, at least a first portion is positioned at the medial edge of the device and, on the other hand, at least a second portion is positioned radially on the bearing face from the medial edge toward the peripheral edge of the rim . - a peripheral edge intended to bear a tire , - a medial edge intended to be in contact with a medial outer surface of the outer ring of the roller, and - two opposite faces producing, on the one hand, an open face and, on the other hand, a bearing face configured to be positioned against the surface of the flange of the track roller,
A press hardened steel part wherein the chemical composition of the steel comprises, in weight: 0.062 ≤ C ≤ 0.095 % 1.4 % ≤ Mn ≤ 1.9 % 0.2 % ≤ Si ≤ 0.5 % 0.020 % ≤ Al ≤ 0.070 % 0.02 % ≤ Cr ≤ 0.1 % , wherein: 1.5 % ≤ C + Mn + Si + Cr ≤ 2.7 % 0.040 % ≤ Nb ≤ 0.060 % 3.4 × N ≤ Ti ≤ 8 × N wherein: 0.044 % ≤ Nb + Ti ≤ 0,090 % 0.0002 ≤ B ≤ 0.004 % 0.001 % ≤ N < 0.007 % 0.0005 % ≤ S ≤ 0.003 % 0.001 % ≤ P ≤ 0.020 % optionally: 0.0001 % ≤ Ca ≤ 0.003 % , the remainder being Fe and unavoidable impurities, and wherein the microstructure comprises, in at least 95% of the volume of said part, in surface fractions: less than 40% of bainite, less than 5% of austenite, less than 5% of ferrite, the remainder being martensite, said martensite consisting of fresh martensite and of self-tempered martensite.
A method for producing a composition comprising inactivated poliovirus particles, said method comprising the steps of: a) producing a medium containing the poliovirus particles; b) purifying the particles from the medium; c) collecting the particles in TRIS buffer having a pH of 6.8 to 7.2 and a concentration in the range of 30 mM - 70 mM, preferably 40 mM; d) stabilising the particles by adding M-199 medium containing glycine to an end concentration of 1x M-199 with 0.05% glycine; e) inactivating the particles by incubation with 0.025% formaldehyde at 37°C for 5 to 13 days; f) adsorbing the particles on aluminium salt adjuvant, whereby the percentage adsorption on alum is at least 95%, and wherein the aluminium salt is aluminium hydroxide at a concentration between 1.5 mg/0.5 mL dose and 2.5 mg/0.5 mL dose at a pH of about 6.5. a) producing a medium containing the poliovirus particles; b) purifying the particles from the medium; c) collecting the particles in TRIS buffer having a pH of 6.8 to 7.2 and a concentration in the range of 30 mM - 70 mM, preferably 40 mM; d) stabilising the particles by adding M-199 medium containing glycine to an end concentration of 1x M-199 with 0.05% glycine; e) inactivating the particles by incubation with 0.025% formaldehyde at 37°C for 5 to 13 days; f) adsorbing the particles on aluminium salt adjuvant, whereby the percentage adsorption on alum is at least 95%, and wherein the aluminium salt is aluminium hydroxide at a concentration between 1.5 mg/0.5 mL dose and 2.5 mg/0.5 mL dose at a pH of about 6.5.