A system for ameliorating a symptom of bacterial meningitis in a patient, the system comprising: a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, the catheter being adapted to be introduced in a cerebrospinal fluid space and the ports being spaced axially apart, wherein the catheter assembly includes a catheter shaft having an inner shaft and an outer shaft , the inner shaft defines an infusion lumen, and an aspiration lumen is defined between the inner shaft and the outer shaft; a pump connectable between the first and second lumens to induce a flow of cerebrospinal fluid therebetween; and a filter component connectable between the first and second lumens, the filter component configured to remove i) one or more gram-negative meningitis causing bacterial pathogen selected from a group including Pseudomonas bacteria, Acinetobacter bacteria, Klebsiella bacteria, or combinations thereof and ii) cytokines selected from the group including IL-1ra, IL-6, TNF, CRP, and CXCL10, or combinations thereof from cerebrospinal fluid, to thereby condition the cerebrospinal fluid; and wherein the filter component includes a first filter to separate cerebrospinal fluid into a first clean cerebrospinal pathway and a first waste pathway , a second filter configured to separate the first waste pathway into a second clean cerebrospinal pathway and a second waste pathway , a waste collection apparatus in fluid communication with the second waste pathway, and a return outlet in fluid communication with the first clean cerebrospinal pathway and the second clean cerebrospinal pathway, wherein the first filter, the second filter, or both is a 5kDa filter. a catheter assembly having a first lumen with a distal port and a second lumen with a proximal port, the catheter being adapted to be introduced in a cerebrospinal fluid space and the ports being spaced axially apart, wherein the catheter assembly includes a catheter shaft having an inner shaft and an outer shaft , the inner shaft defines an infusion lumen, and an aspiration lumen is defined between the inner shaft and the outer shaft; a pump connectable between the first and second lumens to induce a flow of cerebrospinal fluid therebetween; and a filter component connectable between the first and second lumens, the filter component configured to remove i) one or more gram-negative meningitis causing bacterial pathogen selected from a group including Pseudomonas bacteria, Acinetobacter bacteria, Klebsiella bacteria, or combinations thereof and ii) cytokines selected from the group including IL-1ra, IL-6, TNF, CRP, and CXCL10, or combinations thereof from cerebrospinal fluid, to thereby condition the cerebrospinal fluid; and wherein the filter component includes a first filter to separate cerebrospinal fluid into a first clean cerebrospinal pathway and a first waste pathway , a second filter configured to separate the first waste pathway into a second clean cerebrospinal pathway and a second waste pathway , a waste collection apparatus in fluid communication with the second waste pathway, and a return outlet in fluid communication with the first clean cerebrospinal pathway and the second clean cerebrospinal pathway, wherein the first filter, the second filter, or both is a 5kDa filter. <EOS>