A compound of following general formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, wherein: • Het is a nitrogen-containing heterocycloalkyl; • X is a single bond, a (C 1 -C 6 )alkyl group or a (C 1 -C 6 )alkoxy group, in particular a single bond, a (C 1 -C 3 )alkyl group or a (C 1 -C 3 )alkoxy group; • Y is a group selected from -R 10 C(O)NHR 11 ; (C 1 -C 6 )alkyl; or (C 1 -C 6 )alkyl-aryl with (C 1 -C 6 )alkyl optionally substituted with =O, =S or a phenyl and with aryl optionally substituted with one or several substituents selected from hydrogen atom, halo,-CN, - NO 2 , -OR 12 , -NR 13 R 14 , -C(O)OR 15 , -C(O)NR 16 R 17 , -S(O) 2 NR 18 R 19 , -S(O) 2 R 20 , - NHS(O) 2 R 21 , -NHC(O)R 22 , or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkylaryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, -OR 23 or -OC(O)R 24 , or with two adjacent substituents which form together with the carbon atoms to which they are chemically linked an heterocycle; • R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, -NO 2 , -CN, -OR 25 , -NR 26 R 27 , -C(O)OR 28 , -S(O) 2 R 29 , or a (C 1 -C 6 )alkyl group optionally substituted with one or several groups selected from halo or -OR 30 ; • R 10 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, CF 3 or -OR 31 ; • R 31 is hydrogen atom, halo or a (C 1 -C 6 )alkyl group; for use in the prevention and/or the treatment of acne. • Het is a nitrogen-containing heterocycloalkyl; • X is a single bond, a (C 1 -C 6 )alkyl group or a (C 1 -C 6 )alkoxy group, in particular a single bond, a (C 1 -C 3 )alkyl group or a (C 1 -C 3 )alkoxy group; • Y is a group selected from -R 10 C(O)NHR 11 ; (C 1 -C 6 )alkyl; or (C 1 -C 6 )alkyl-aryl with (C 1 -C 6 )alkyl optionally substituted with =O, =S or a phenyl and with aryl optionally substituted with one or several substituents selected from hydrogen atom, halo,-CN, - NO 2 , -OR 12 , -NR 13 R 14 , -C(O)OR 15 , -C(O)NR 16 R 17 , -S(O) 2 NR 18 R 19 , -S(O) 2 R 20 , - NHS(O) 2 R 21 , -NHC(O)R 22 , or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkylaryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, -OR 23 or -OC(O)R 24 , or with two adjacent substituents which form together with the carbon atoms to which they are chemically linked an heterocycle; • R 1 to R 4 are, independently of one another, hydrogen atom or a group selected from halo, -NO 2 , -CN, -OR 25 , -NR 26 R 27 , -C(O)OR 28 , -S(O) 2 R 29 , or a (C 1 -C 6 )alkyl group optionally substituted with one or several groups selected from halo or -OR 30 ; • R 10 to R 30 are, independently of one another, hydrogen atom, halo, or a group selected from (C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkyl-aryl, heterocycle, (C 1 -C 6 )alkyl-heterocycle, said group being optionally substituted with one or several groups selected from halo, (C 1 -C 6 )alkyl, CF 3 or -OR 31 ; • R 31 is hydrogen atom, halo or a (C 1 -C 6 )alkyl group; <EOS>