mhurhangee/patent-ind-claim-en huggingface dataset:
A derivative of a GLP-1 peptide, wherein the GLP-1 peptide comprises a first, a second, and a third K residue at positions corresponding to positions , , , , or of GLP-1(7-37) (SEQ ID NO: 1), has a maximum of seven amino acid changes as compared to GLP-1(7-37) (SEQ ID NO: 1), and has the general formula I: wherein Xaa 7 is L-histidine; Xaa 8 is Aib; Xaa 12 is Phe; Xaa 16 is Val; Xaa 18 is Ser or Lys; Xaa 19 is Tyr; Xaa 20 is Leu; Xaa 22 is Gly, Lys, or Glu; Xaa 23 is Gln; Xaa 25 is Ala; Xaa 26 is Arg or Lys; Xaa 27 is Glu or Lys; Xaa 30 is Ala or Lys; Xaa 31 is Trp; Xaa 33 is Val; Xaa 34 is Arg; Xaa 35 is Gly; Xaa 36 is Arg; and Xaa 37 is Gly or Lys; which derivative comprises a first, a second, and a third protracting moiety selected from formula Chem. 1, Chem. 1a, and formula Chem. 2: Chem. 1: HOOC-(CH 2 ) 16 -CO-*, Chem. 1a: HOOC-(CH 2 ) 18 -CO-*, and Chem. 2: HO 3 S-(CH 2 ) 15 -CO*; wherein the first, the second, and the third protracting moieties are identical and a first, a second, and a third linker, each linker comprising a *-CO group and an *-NH group; wherein the first, the second, and the third linkers are identical and each protracting moiety is attached at its *-CO end to the *-NH end of the respective linker, and each linker is attached at its *-CO end to the epsilon amino group of the respective K residue of the GLP-1 peptide; or a pharmaceutically acceptable salt, amide, or ester thereof. wherein the first, the second, and the third protracting moieties are identical and a first, a second, and a third linker, each linker comprising a *-CO group and an *-NH group; wherein the first, the second, and the third linkers are identical and each protracting moiety is attached at its *-CO end to the *-NH end of the respective linker, and each linker is attached at its *-CO end to the epsilon amino group of the respective K residue of the GLP-1 peptide; or a pharmaceutically acceptable salt, amide, or ester thereof.
Method for scanning microscopy, wherein a sample is scanned simultaneously with a plurality of illumination spots of excitation light, wherein the light emitted by a sample location being irradiated by an illumination spot is being detected independently from the light which is emitted by another sample location being illuminated by another illumination spot , and wherein a microscopic image of the sample can be put together from the emitted light detected for the different locations of the sample , wherein the intensities of the different illumination spots are being adjusted independently from each other and wherein the illumination spots are being guided over the sample in one scan line behind each other, characterized in that a leading illumination spot and a following illumination spot are being guided over the sample and that an intensity of the light emitted from a sample location measured for the leading illumination spot is being used for adjusting an intensity of the following illumination spot when the following illumination spot hits this sample location .
Drill pipe for use during the creation of a borehole in ground from a starting point to a target point along a predetermined drill line, wherein the borehole is gradually created by means of a drilling device comprising a drilling tool for loosening the ground as the drill pipes are advanced, wherein the drill pipe has at each of its ends at least one connection section for detachably connecting it to a further element of a drill string in a tensile-resistant manner, wherein the drill pipe has at least one element for producing a tensile-resistant connection to a corresponding element of an advancing device for advancing the drill pipe into and/or retracting it from the borehole, wherein an outer wall of the drill pipe is made in one piece, wherein the connection by the respective connection sections of the drill pipe to another element of the drill string occurs in the form of a positive-locking and/or a non-positive-locking connection, and wherein the drill pipe has at its first end a first connection section and at its opposite second end a second connection section corresponding to the first connection section , wherein the drill pipe has at least two conduit sections arranged in the inner space of the drill pipe at the outer wall and extending in parallel along the outer wall , wherein the at least two conduit sections have at each of their ends a connection element for producing a connection between conduit sections of interconnected drill pipes , wherein the first connection section and the second corresponding connection section form, in the mounted state, a flange connection which has connection elements and/or bores for placement of a bolt connection, wherein the first connection section has a support section in which the bores are provided, characterized in that , behind the support section , an indentation is provided in the outer wall of the drill pipe , and in that the indentation can be closed with a covering .
An article including: a first sleeve formed from a first heat-shrinkable polymer sheet , the first heat-shrinkable polymer sheet having opposed first and second edges , wherein the first sleeve is formed with a first seam proximate the first edge ; a portion of the first heat-shrinkable polymer sheet that extends between the first seam and the second edge ; and a tag bonded to the portion of the first heat-shrinkable polymer sheet proximate the second edge at a first overlap zone of the tag and the portion of the first heat-shrinkable polymer sheet ; wherein the first seam is substantially linear, and wherein a height dimension of the tag parallel to the first seam is equal to or less than a length of the first seam between first and second open ends of the first sleeve ; and characterized by a neck is disposed on the portion of the first heat-shrinkable polymer sheet , the neck having a dimension measured parallel to the height dimension of the tag that is less than the height dimension of the tag . a first sleeve formed from a first heat-shrinkable polymer sheet , the first heat-shrinkable polymer sheet having opposed first and second edges , wherein the first sleeve is formed with a first seam proximate the first edge ; a portion of the first heat-shrinkable polymer sheet that extends between the first seam and the second edge ; and a tag bonded to the portion of the first heat-shrinkable polymer sheet proximate the second edge at a first overlap zone of the tag and the portion of the first heat-shrinkable polymer sheet ; wherein the first seam is substantially linear, and wherein a height dimension of the tag parallel to the first seam is equal to or less than a length of the first seam between first and second open ends of the first sleeve ; and characterized by a neck is disposed on the portion of the first heat-shrinkable polymer sheet , the neck having a dimension measured parallel to the height dimension of the tag that is less than the height dimension of the tag .
A CPR training manikin having size and shape of a torso area of a human, the CPR training manikin comprising: a lighted rate monitor assembly including: a base member , the base member including an electronic control board; a chest compression assembly joined to the base member, the chest compression assembly comprising input devices electrically connected to the electronic control board; and a cord assembly at a proximal cord assembly end for electrical connection with the electronic control board, and having a light at a distal cord assembly end , characterized in that the cord assembly has a plug member for removable electrical connection with the electronic control board, the CPR training manikin further comprises a torso portion, a portion of the torso portion defining a manikin opening through which the cord assembly , extending from the interior of the CPR training manikin to be visible externally, traverses between the proximal cord assembly end and the distal cord assembly end , and the light is housed within a light housing having a transparent lens portion covering the light and including a placement clip disposed at or near the distal cord assembly end allowing the light to be clipped in a user-visible position during operation of the CPR training manikin , wherein the base member further includes a pocket into which the light and/or distal cord assembly end can be fit for storing. a lighted rate monitor assembly including: a base member , the base member including an electronic control board; a chest compression assembly joined to the base member, the chest compression assembly comprising input devices electrically connected to the electronic control board; and a base member , the base member including an electronic control board; a chest compression assembly joined to the base member, the chest compression assembly comprising input devices electrically connected to the electronic control board; and a cord assembly at a proximal cord assembly end for electrical connection with the electronic control board, and having a light at a distal cord assembly end , characterized in that the cord assembly has a plug member for removable electrical connection with the electronic control board, the CPR training manikin further comprises a torso portion, a portion of the torso portion defining a manikin opening through which the cord assembly , extending from the interior of the CPR training manikin to be visible externally, traverses between the proximal cord assembly end and the distal cord assembly end , and the light is housed within a light housing having a transparent lens portion covering the light and including a placement clip disposed at or near the distal cord assembly end allowing the light to be clipped in a user-visible position during operation of the CPR training manikin , wherein the base member further includes a pocket into which the light and/or distal cord assembly end can be fit for storing.
A process of retraction of sulcus , comprising the steps of: i. applying an elastomeric material, preferably a silicone material , a polyurethane material and/or a polyether material onto and/or at the vicinity of the boundary of a tooth and adjacent gingiva and/or sulcus , which elastomeric material expands during or after its curing reaction; ii. applying a cap onto said tooth , thereby forming a chamber over said.elastomeric material , wherein said chamber comprises as its walls the tooth , the cap and an outer section of said gingiva ; whereby said chamber allows for the elastomeric material to expand into the sulcus , characterized in that - said cap is at least partially filled with a plastically deformable, especially malleable material when applied onto said tooth in step ii.; and/or that - said cap is deformable, especially under biting pressure. i. applying an elastomeric material, preferably a silicone material , a polyurethane material and/or a polyether material onto and/or at the vicinity of the boundary of a tooth and adjacent gingiva and/or sulcus , which elastomeric material expands during or after its curing reaction; ii. applying a cap onto said tooth , thereby forming a chamber over said.elastomeric material , wherein said chamber comprises as its walls the tooth , the cap and an outer section of said gingiva ; - said cap is at least partially filled with a plastically deformable, especially malleable material when applied onto said tooth in step ii.; - said cap is deformable, especially under biting pressure.
An elastography system comprising: a hand-held elastography device including: a housing ; a probing element removably attached to the housing; and a force sensor attached within the housing so as to have a fixed spatial relationship relative to the probing element and a fixed spatial relationship relative to the housing, the force sensor connected to the probing element; and a position sensing device connected to the elastography device; wherein the force sensor is configured to produce a signal indicative of a force applied to the probing element upon insertion of the probing element into a material, and the elastography system further comprises a processing unit connected to the force sensor, wherein the processing unit is configured to, based on changes in the signal, derive a mapping of spatial variations of a material property within the material in response to the variations of the material property during traversal of the probing element along an insertion path through the material. a housing ; a probing element removably attached to the housing; and a force sensor attached within the housing so as to have a fixed spatial relationship relative to the probing element and a fixed spatial relationship relative to the housing, the force sensor connected to the probing element; and
A multi-stage float sorting device , comprising: a first flotator float-sorting ores mixed with water based on a difference in density; and a second flotator provided with a column extending in a top-down direction, one side of which communicates with the first flotator to receive primary concentrates , and float-sorts the primary concentrates based on a difference in density to obtain secondary concentrates, wherein the second flotator comprises: a washing water jetting section provided at a top of the column to jet washing water so as to separate impurity minerals from the primary concentrates ; a gas sparger provided at a bottom of the column to jet an inert gas so as to generate bubbles; and characterized by an opening and closing section located between the washing water jetting section and the gas sparger to partition an inside of the column into upper and lower regions, and form an opening so as to allow secondary concentrates accommodated in the column to rise when the pressure of the lower region exceeds a set value as the inert gas is supplied. a first flotator float-sorting ores mixed with water based on a difference in density; and a second flotator provided with a column extending in a top-down direction, one side of which communicates with the first flotator to receive primary concentrates , and float-sorts the primary concentrates based on a difference in density to obtain secondary concentrates, wherein the second flotator comprises: a washing water jetting section provided at a top of the column to jet washing water so as to separate impurity minerals from the primary concentrates ; a gas sparger provided at a bottom of the column to jet an inert gas so as to generate bubbles; and characterized by an opening and closing section located between the washing water jetting section and the gas sparger to partition an inside of the column into upper and lower regions, and form an opening so as to allow secondary concentrates accommodated in the column to rise when the pressure of the lower region exceeds a set value as the inert gas is supplied. a washing water jetting section provided at a top of the column to jet washing water so as to separate impurity minerals from the primary concentrates ; a gas sparger provided at a bottom of the column to jet an inert gas so as to generate bubbles; and characterized by an opening and closing section located between the washing water jetting section and the gas sparger to partition an inside of the column into upper and lower regions, and form an opening so as to allow secondary concentrates accommodated in the column to rise when the pressure of the lower region exceeds a set value as the inert gas is supplied.
A gaseous hydrogen producing apparatus comprising a container provided with: - an input for water comprising elecro-injectors configured to provide water in atomized form into the container at a peripheral chamber of the same; - an acoustic-wave generator suitable for inducing sonolysis in the water introduced into the container at the peripheral chamber ; - an electromagnetic radiation source configured to induce photolysis in the water introduced into the container, disposed proximate to the acoustic-wave generator into the peripheral chamber ; - a device adapted to induce electrolysis and arranged in a central region of the container downstream of the acoustic-wave generator and of the source of the electromagnetic radiation ; - a first heater included in the peripheral chamber and configured to vaporize the water that is introduced into the container at the peripheral chamber to provide corresponding vapor, wherein said device for inducing electrolysis is arranged so as to induce electrolysis on said vapor; - an output for providing hydrogen in the gaseous state exiting the container. - an input for water comprising elecro-injectors configured to provide water in atomized form into the container at a peripheral chamber of the same; - an acoustic-wave generator suitable for inducing sonolysis in the water introduced into the container at the peripheral chamber ; - an electromagnetic radiation source configured to induce photolysis in the water introduced into the container, disposed proximate to the acoustic-wave generator into the peripheral chamber ; - a device adapted to induce electrolysis and arranged in a central region of the container downstream of the acoustic-wave generator and of the source of the electromagnetic radiation ; - a first heater included in the peripheral chamber and configured to vaporize the water that is introduced into the container at the peripheral chamber to provide corresponding vapor, wherein said device for inducing electrolysis is arranged so as to induce electrolysis on said vapor; - an output for providing hydrogen in the gaseous state exiting the container.
Method for monitoring a sliding bearing having a shaft mounted therein, in particular a shaft rotating therein, for at least one mixed friction event (a, b, c, d), wherein at least one time-dependent structure-borne sound signal (S) is picked up from the sliding bearing by at least one structure-borne sound sensor , in particular precisely one structure-borne sound sensor , characterized by a) filtering of the structure-borne sound signal (S), b) subsequent calculation of an envelope curve for the filtered structure-borne sound signal (S), c) subsequent smoothing of the envelope curve, and d) combination of the data for the smoothed envelope curve with a rotational angle signal (Z) dependent on the revolution of the shaft in the sliding bearing , wherein the rotational angle signal (Z) is determined and/or generated by pattern recognition or a reference pulse, in particular a magnetic reference pulse, by means of an incremental encoder, e) calculation of at least one maximum from the smoothed envelope curve, which is correlated with the at least one mixed friction event (a, b, c, d), from the combined data from step d) for determining an angle specification for the at least one mixed friction event (a, b, c, d) at the circumference of the sliding bearing . a) filtering of the structure-borne sound signal (S), b) subsequent calculation of an envelope curve for the filtered structure-borne sound signal (S), c) subsequent smoothing of the envelope curve, and d) combination of the data for the smoothed envelope curve with a rotational angle signal (Z) dependent on the revolution of the shaft in the sliding bearing , wherein the rotational angle signal (Z) is determined and/or generated by pattern recognition or a reference pulse, in particular a magnetic reference pulse, by means of an incremental encoder, e) calculation of at least one maximum from the smoothed envelope curve, which is correlated with the at least one mixed friction event (a, b, c, d), from the combined data from step d) for determining an angle specification for the at least one mixed friction event (a, b, c, d) at the circumference of the sliding bearing .
A reactor for performing a chemical reaction, which has a reactor vessel and one or more reaction tubes , wherein one or more current feed elements is or are led into the reactor vessel for electrically heating the one or more reaction tubes , characterized in that - the one or more current feed elements has or have one or each rod-shaped section , and the rod-shaped section or sections extends or extend through a wall of the reactor vessel at one or each wall passage , - outside the reactor vessel and subsequently to the wall of the reactor vessel in which the wall passage or passages is or are designed, there is a connection chamber into which the rod-shaped section or sections projects or project, - gas feed means (80-82) are provided, which are set up to apply inerting gas to the connection chamber , and - the wall passage(s) with the rod-shaped section(s) received therein in a longitudinally movable manner are designed to be gas-permeable so that at least a portion of the inerting gas fed into the connection chamber flows into the reactor vessel . - the one or more current feed elements has or have one or each rod-shaped section , and the rod-shaped section or sections extends or extend through a wall of the reactor vessel at one or each wall passage , - outside the reactor vessel and subsequently to the wall of the reactor vessel in which the wall passage or passages is or are designed, there is a connection chamber into which the rod-shaped section or sections projects or project, - gas feed means (80-82) are provided, which are set up to apply inerting gas to the connection chamber , and - the wall passage(s) with the rod-shaped section(s) received therein in a longitudinally movable manner are designed to be gas-permeable so that at least a portion of the inerting gas fed into the connection chamber flows into the reactor vessel .