mhurhangee/patent-ind-claim-en huggingface dataset:
A double-stranded RNAi agent capable of inhibiting the expression of a target gene, comprising a sense strand and an antisense strand, each strand having 14 to 30 nucleotides, wherein the duplex is represented by formula (III): wherein: i, j, k, and I are each independently 0 or 1; p and q are each independently 0-6; each Na and Na' independently represents an oligonucleotide sequence comprising 0-25 nucleotides which are either modified or unmodified or combinations thereof, each sequence comprising at least two differently modified nucleotides, each N b and N b ' independently represents an oligonucleotide sequence comprising 0-10 nucleotides which are either modified or unmodified or combinations thereof; each n p , n p ', n q and n q ' independently represents an overhang nucleotide sequence comprising 0-6 nucleotides; and XXX, YYY, ZZZ, X'X'X', Y'Y'Y', and Z'Z'Z' each independently represent one motif of three identical modifications on three consecutive nucleotides; the Y'Y'Y' motif occurs at the 11, 12 and 13 positions of the antisense strand from the 5'-end; the Y' is 2'-OMe; said agent further comprises at least one phosphorothioate internucleotide linkage, wherein the antisense strand comprises two blocks of two phosphorothioate internucleotide linkages separated by 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18 phosphate internucleotide linkages, and said antisense strand is paired with a sense strand comprising any combination of phosphorothioate, methylphosphonate and phosphate internucleotide linkages; and wherein the modification on Nb is different than the modification on Y and the modification on Nb' is different than the modification on Y'. i, j, k, and I are each independently 0 or 1; p and q are each independently 0-6; each Na and Na' independently represents an oligonucleotide sequence comprising 0-25 nucleotides which are either modified or unmodified or combinations thereof, each sequence comprising at least two differently modified nucleotides, each N b and N b ' independently represents an oligonucleotide sequence comprising 0-10 nucleotides which are either modified or unmodified or combinations thereof; each n p , n p ', n q and n q ' independently represents an overhang nucleotide sequence comprising 0-6 nucleotides; and XXX, YYY, ZZZ, X'X'X', Y'Y'Y', and Z'Z'Z' each independently represent one motif of three identical modifications on three consecutive nucleotides; the Y'Y'Y' motif occurs at the 11, 12 and 13 positions of the antisense strand from the 5'-end; the Y' is 2'-OMe; said agent further comprises at least one phosphorothioate internucleotide linkage, wherein the antisense strand comprises two blocks of two phosphorothioate internucleotide linkages separated by 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18 phosphate internucleotide linkages, and said antisense strand is paired with a sense strand comprising any combination of phosphorothioate, methylphosphonate and phosphate internucleotide linkages; and wherein the modification on Nb is different than the modification on Y and the modification on Nb' is different than the modification on Y'.
An information processing apparatus comprising: a signal processing unit adapted to determine a signal strength of a first signal received from a first apparatus in a first network based on a first threshold, the first network being a network which the information processing apparatus belongs to; determine a signal strength of a second signal received from a second apparatus in a second network which is different from the first network, based on a second signal threshold, the second signal threshold being used for overlapping network; and generate a third signal threshold by using a relative value and the signal strength of the second signal received from the second network, the relative value being set in accordance with a relative distance between the information processing apparatus, the first apparatus and the second apparatus, when a signal state of the second signal is determined as idle based on the second signal threshold, wherein the signal processing unit comprises a judging unit adapted to determine the signal strength of the second signal based on the third signal threshold to judge whether to allow signal transmission during a period while the second signal from the second network occupies a medium. a signal processing unit adapted to determine a signal strength of a first signal received from a first apparatus in a first network based on a first threshold, the first network being a network which the information processing apparatus belongs to; determine a signal strength of a second signal received from a second apparatus in a second network which is different from the first network, based on a second signal threshold, the second signal threshold being used for overlapping network; and generate a third signal threshold by using a relative value and the signal strength of the second signal received from the second network, the relative value being set in accordance with a relative distance between the information processing apparatus, the first apparatus and the second apparatus, when a signal state of the second signal is determined as idle based on the second signal threshold, wherein the signal processing unit comprises a judging unit adapted to determine the signal strength of the second signal based on the third signal threshold to judge whether to allow signal transmission during a period while the second signal from the second network occupies a medium.
A frame apparatus for holding a flexible lance positioning and drive device adjacent to and spaced from a heat exchanger tube sheet, the apparatus comprising: a guide rail; a positioner support rail supported from the guide rail ; and a positioner support rail carriage movably mounted on the guide rail ; a flexible lance drive support carriage movably mounted on the positioner support rail ; and an air motor drive assembly fastened to each of the positioner support rail carriage and the lance drive support carriage , each air motor drive assembly comprising an air motor having a shaft driving a spur gear in a spur gear housing fastened to one of the flexible lance drive support carriage and the positioner support rail carriage characterised in that each spur gear housing is selectively rotatable between a locked position with the spur gear engaging the rail to which the carriage is mounted and an unlocked position with the spur gear disengaged with the rail to which the carriage is mounted. a guide rail; a positioner support rail supported from the guide rail ; and a positioner support rail carriage movably mounted on the guide rail ; a flexible lance drive support carriage movably mounted on the positioner support rail ; and an air motor drive assembly fastened to each of the positioner support rail carriage and the lance drive support carriage , each air motor drive assembly comprising an air motor having a shaft driving a spur gear in a spur gear housing fastened to one of the flexible lance drive support carriage and the positioner support rail carriage characterised in that each spur gear housing is selectively rotatable between a locked position with the spur gear engaging the rail to which the carriage is mounted and an unlocked position with the spur gear disengaged with the rail to which the carriage is mounted.
A personal care device comprising a head portion having a driven treatment head ; a handle portion having a drive unit for providing a motion having a motion direction; and a drive train extending between the drive unit and the driven treatment head for transmitting the motion from the drive unit to the driven treatment head , the drive train comprising a separable coupling ; the separable coupling comprising a first coupling part having a first coupling element ; a second coupling part having a second coupling element , the first and the second coupling elements being separably engaged with each other; and a resilient element biasing the first coupling element and the second coupling element against each other so that the first and second coupling elements are engaged in a gap-free manner along the motion direction; wherein the driven treatment head and the handle portion are arranged for being pivotable with respect to each other around at least a first pivot axis and the separable coupling is a separable universal joint. a head portion having a driven treatment head ; a handle portion having a drive unit for providing a motion having a motion direction; and a drive train extending between the drive unit and the driven treatment head for transmitting the motion from the drive unit to the driven treatment head , the drive train comprising a separable coupling ; the separable coupling comprising a first coupling part having a first coupling element ; a second coupling part having a second coupling element , the first and the second coupling elements being separably engaged with each other; and a resilient element biasing the first coupling element and the second coupling element against each other so that the first and second coupling elements are engaged in a gap-free manner along the motion direction; a first coupling part having a first coupling element ; a second coupling part having a second coupling element , the first and the second coupling elements being separably engaged with each other; and a resilient element biasing the first coupling element and the second coupling element against each other so that the first and second coupling elements are engaged in a gap-free manner along the motion direction; wherein the driven treatment head and the handle portion are arranged for being pivotable with respect to each other around at least a first pivot axis and the separable coupling is a separable universal joint.
An engine having an engine shaft and a piston configured to reciprocate within a cylinder chamber having an axis , each piston having an first piston part and piston stem to move in unison with or separately from a second piston part to define piston strokes for different thermal functions of the engine, the engine comprising: a linkage assembly having a first end coupled to the engine and a second end coupled to the piston stem defining a copy point; an actuator that engages the linkage assembly; a guide cam that engages a guide cam follower coupled to the linkage assembly; and a return mechanism configured to bias movement of the linkage assembly against one of the actuator or the guide cam , wherein the actuator and the guide cam are operable to control motion of the linkage assembly to thereby define substantially linear movement of the copy point along the cylinder chamber axis. a linkage assembly having a first end coupled to the engine and a second end coupled to the piston stem defining a copy point; an actuator that engages the linkage assembly; a guide cam that engages a guide cam follower coupled to the linkage assembly; and a return mechanism configured to bias movement of the linkage assembly against one of the actuator or the guide cam , wherein the actuator and the guide cam are operable to control motion of the linkage assembly to thereby define substantially linear movement of the copy point along the cylinder chamber axis.
A patient interface device , comprising: a shell defining a chamber within; a first interface port configured to be interfaced with a patient's eye , the first interface port being disposed at a first side of the shell and including an applanating lens for application to the patient's eye during a laser surgery procedure; a second interface port disposed at a second side of the shell and configured to be interfaced with a laser surgery apparatus , wherein the device is configured to allow air to be evacuated from the chamber by the laser surgery apparatus via the second interface port; and a light guiding structure having at a first end thereof a light receiving interface , configured to receive light, and having at a second end thereof a light-emitting interface , wherein the light-emitting interface is disposed adjacent the applanating lens and configured to provide the light in a vicinity of the patient's eye when the applanating lens is applied to the patient's eye, wherein the first interface port includes a plurality of vacuum channels configured for the laser surgery apparatus to apply a vacuum to the applanating lens via the chamber. a shell defining a chamber within; a first interface port configured to be interfaced with a patient's eye , the first interface port being disposed at a first side of the shell and including an applanating lens for application to the patient's eye during a laser surgery procedure; a second interface port disposed at a second side of the shell and configured to be interfaced with a laser surgery apparatus , wherein the device is configured to allow air to be evacuated from the chamber by the laser surgery apparatus via the second interface port; and a light guiding structure having at a first end thereof a light receiving interface , configured to receive light, and having at a second end thereof a light-emitting interface , wherein the light-emitting interface is disposed adjacent the applanating lens and configured to provide the light in a vicinity of the patient's eye when the applanating lens is applied to the patient's eye, wherein the first interface port includes a plurality of vacuum channels configured for the laser surgery apparatus to apply a vacuum to the applanating lens via the chamber.
A tire comprising a depthwise structure on at least a part of a sidewall portion, the depthwise structure comprising, in a depth direction from a point on a sidewall portion outer surface, a depthwise part I from the sidewall portion outer surface to 0.5 mm and a depthwise part II from 0.5 mm to 1.0 mm, wherein: the depthwise part I and the depthwise part II satisfy the following requirement: the depthwise part I: a peak temperature T1 (°C) of tan δ is -20°C or more and -5°C or less, and when tan δ at the peak temperature T1 (°C) is α1 and a storage modulus at the peak temperature T1 (°C) is E'1 (MPa), α1≤0.90 and E'1≥5MPa; and the depthwise part II: when tan δ at the peak temperature T1 (°C) is α2, and a storage modulus at the peak temperature T1 (°C) is E'2 (MPa), α2<α1 and E'2<E'1. the depthwise part I: a peak temperature T1 (°C) of tan δ is -20°C or more and -5°C or less, and when tan δ at the peak temperature T1 (°C) is α1 and a storage modulus at the peak temperature T1 (°C) is E'1 (MPa), α1≤0.90 and E'1≥5MPa; and the depthwise part II: when tan δ at the peak temperature T1 (°C) is α2, and a storage modulus at the peak temperature T1 (°C) is E'2 (MPa), α2<α1 and E'2<E'1.
A header for an agricultural harvester comprising: an drive gear train operatively connected to a first cutter bar ; an driven gear train operatively connected to a second cutter bar ; characterized in that the drive gear trains are epicyclical drive gear trains and in that the header further comprises a shaft extending between and operatively connected to the epicyclical drive gear train and the epicyclical driven gear train. an drive gear train operatively connected to a first cutter bar ; an driven gear train operatively connected to a second cutter bar ; characterized in that the drive gear trains are epicyclical drive gear trains and in that the header further comprises a shaft extending between and operatively connected to the epicyclical drive gear train and the epicyclical driven gear train.
Device for liquid disinfection having UV emitters, which are housed in parallel casing tubes , and having at least one carriage which is displaceably guided along the casing tubes and which comprises slit or helically wound cleaning elements which annularly surround the casing tubes and which are held in a peripheral groove of slit housing rings mounted in the carriage with radial clearance, characterised in that the annular cleaning elements lie against the groove bottom of the peripheral groove receiving them, and in that the slit housing rings are surrounded with elastic tension rings under pretensioning.
A roller assembly comprising: a track roller having a roller inner surface with a varying roller inner diameter; and a roller shaft having shaft outer surface with a shaft outer diameter, wherein the shaft outer surface and the roller inner surface are configured so that the track roller can rotate about the roller shaft ; a first collar that is press fit onto a first shaft end ; and a second collar that is press fit onto a second shaft end ; characterised in that , the roller shaft is compressible to reduce a shaft length of the roller shaft from a shaft normal length to a shaft compressed length and is configured such that a collar axial clearance of the first collar and the second collar from the roller inner surface is created by compressing the roller shaft with a compressive axial load when the track roller prevents axial inward movement of the first collar and the second collar , and then removing the compressive axial load from the roller shaft to allow the first collar and the second collar to move axially outwardly as the roller shaft extends from the shaft compressed length to the shaft normal length. a track roller having a roller inner surface with a varying roller inner diameter; and a roller shaft having shaft outer surface with a shaft outer diameter, wherein the shaft outer surface and the roller inner surface are configured so that the track roller can rotate about the roller shaft ; a first collar that is press fit onto a first shaft end ; and a second collar that is press fit onto a second shaft end ; characterised in that , the roller shaft is compressible to reduce a shaft length of the roller shaft from a shaft normal length to a shaft compressed length and is configured such that a collar axial clearance of the first collar and the second collar from the roller inner surface is created by compressing the roller shaft with a compressive axial load when the track roller prevents axial inward movement of the first collar and the second collar , and then removing the compressive axial load from the roller shaft to allow the first collar and the second collar to move axially outwardly as the roller shaft extends from the shaft compressed length to the shaft normal length.
A space vehicle, comprising: one or more magnetorquers operable to change an attitude of the space vehicle in an external magnetic field, each magnetorquer comprising a coil; characterized by a switching circuit configured to short-circuit the coil of at least one of the magnetorquers so that a closed electric circuit comprising said coil is formed, for damping tumbling motion of the space vehicle in the external magnetic field; wherein the switching circuit is configured to short-circuit the coil of the at least one magnetorquer upon occurrence of a condition indicative of end-of-life or failure of the space vehicle. one or more magnetorquers operable to change an attitude of the space vehicle in an external magnetic field, each magnetorquer comprising a coil; characterized by a switching circuit configured to short-circuit the coil of at least one of the magnetorquers so that a closed electric circuit comprising said coil is formed, for damping tumbling motion of the space vehicle in the external magnetic field; wherein the switching circuit is configured to short-circuit the coil of the at least one magnetorquer upon occurrence of a condition indicative of end-of-life or failure of the space vehicle.
A method of wireless communication for a user equipment, UE , comprising: associating with an access point of a wireless local area network, WLAN; obtaining a prioritized list comprising a plurality of public land mobile network, PLMN, entries and one or more selection conditions associated with each one of the plurality of PLMN entries which indicate the condition or conditions under which a particular PLMN should be selected from the list by the UE ; selecting a PLMN from the list when the one or more selection conditions are satisfied; and discovering an evolved packet data gateway, ePDG , associated with the selected PLMN, wherein the discovering comprises: determining a fully qualified domain name, FQDN, for the ePDG based at least in part on an FQDN rule for the selected PLMN; and obtaining an Internet Protocol, IP, address for the ePDG using a domain name server, DNS, query for the FQDN. associating with an access point of a wireless local area network, WLAN; obtaining a prioritized list comprising a plurality of public land mobile network, PLMN, entries and one or more selection conditions associated with each one of the plurality of PLMN entries which indicate the condition or conditions under which a particular PLMN should be selected from the list by the UE ; selecting a PLMN from the list when the one or more selection conditions are satisfied; and discovering an evolved packet data gateway, ePDG , associated with the selected PLMN, wherein the discovering comprises: determining a fully qualified domain name, FQDN, for the ePDG based at least in part on an FQDN rule for the selected PLMN; and obtaining an Internet Protocol, IP, address for the ePDG using a domain name server, DNS, query for the FQDN. determining a fully qualified domain name, FQDN, for the ePDG based at least in part on an FQDN rule for the selected PLMN; and obtaining an Internet Protocol, IP, address for the ePDG using a domain name server, DNS, query for the FQDN.