mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of formula (I), its diastereoisomers or its enantiomers, and/or isotopic derivative Wherein each R 1 and R 2 is independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, alkylcarboxy, arylcarboxy and -OSiP 1 P 2 P 3 , R 3 is hydrogen or a methylene group (=CH 2 ), Each of R 4 and R 5 is independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, alkylcarboxy, arylcarboxy and -OSiP 1 P 2 P 3 , at least one of R 4 and R 5 hydrogen, X is selected from (C 1 -C 6 ) alkyl, aryl, arylalkyl, heteroalkyl and heterocycle, R 6 is selected from hydrogen and alkyl, W is selected from -CO 2 R a , -CONR a R b and -CN, A represents a single or double bond, each of P 1 , P 2 , P 3 is independently selected from alkyl, aryl, arylalkyl and heterocycle, each of R a and R b is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl and heterocycle, with the proviso that if A is a single bond then one of the following conditions is true: a) R 5 is hydrogen, or b) X is different from -CH 3 , -CH 2 CH 3 , -CH 2 OH, ethenyl and ethynyl or a compound of formula (X), its diastereoisomers or its enantiomers, and/or isotopic derivative where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and A are as their definitions for formula (I), and each of Y 1 and Y 2 is independently selected from C 1 -C 6 alkyl, aryl, arylalkyl, heterocycle, with the proviso that X is not -CH 3 , -CH 2 CH 3 , -CH 2 OH, ethenyl or ethynyl, and Y 1 and Y 2 are not isopropyl, wherein X in formula (I) and (X) is isotopically labelled. Wherein each R 1 and R 2 is independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, alkylcarboxy, arylcarboxy and -OSiP 1 P 2 P 3 , R 3 is hydrogen or a methylene group (=CH 2 ), Each of R 4 and R 5 is independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, alkylcarboxy, arylcarboxy and -OSiP 1 P 2 P 3 , at least one of R 4 and R 5 hydrogen, X is selected from (C 1 -C 6 ) alkyl, aryl, arylalkyl, heteroalkyl and heterocycle, R 6 is selected from hydrogen and alkyl, W is selected from -CO 2 R a , -CONR a R b and -CN, A represents a single or double bond, each of P 1 , P 2 , P 3 is independently selected from alkyl, aryl, arylalkyl and heterocycle, each of R a and R b is independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl and heterocycle, with the proviso that if A is a single bond then one of the following conditions is true: a) R 5 is hydrogen, or b) X is different from -CH 3 , -CH 2 CH 3 , -CH 2 OH, ethenyl and ethynyl or where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and A are as their definitions for formula (I), and each of Y 1 and Y 2 is independently selected from C 1 -C 6 alkyl, aryl, arylalkyl, heterocycle, with the proviso that X is not -CH 3 , -CH 2 CH 3 , -CH 2 OH, ethenyl or ethynyl, and Y 1 and Y 2 are not isopropyl, wherein X in formula (I) and (X) is isotopically labelled.
A method for performing a search on a Content Addressable Memory - CAM comprising: determining which bank of a plurality of banks of a dictionary entry of the content addressable memory, CAM, has the highest probability of not matching a segment of an input word; pre-charging a match line associated with the determined bank; comparing the segment of the input word to the bank, the match line indicating the result of the comparison; incrementing a counter associated with the bank when the match line indicates the segment of the input word and the bank are not a match, wherein the probability of not matching is based on the counter; and wherein other banks of the dictionary entry are not pre-charged. determining which bank of a plurality of banks of a dictionary entry of the content addressable memory, CAM, has the highest probability of not matching a segment of an input word; pre-charging a match line associated with the determined bank; comparing the segment of the input word to the bank, the match line indicating the result of the comparison; incrementing a counter associated with the bank when the match line indicates the segment of the input word and the bank are not a match, wherein the probability of not matching is based on the counter; and wherein other banks of the dictionary entry are not pre-charged.
A downhole flow device for controlling a flow of fluid between an annulus and an inner bore of a well tubular metal structure arranged in a borehole , comprising: - a tubular part comprising a first opening and an axial extension, and - a sliding sleeve configured to slide within the tubular part between a first position covering the opening and a second position fully uncovering the opening, the tubular part comprising a first groove and a second groove , the first groove being arranged at a first distance (di) from the second groove along the axial extension, and the sliding sleeve comprising a projecting part configured to engage the first groove in the first position and the second groove in the second position, characterised in that the tubular part comprises a third groove configured to be engaged by the projecting part and having a second distance (d 2 ) to the second groove which is smaller than the first distance, wherein the first groove , the second groove and the third groove are arranged in order so that the first groove is arranged next to the second groove , and the third groove is arranged next to the second groove along the axial extension. - a tubular part comprising a first opening and an axial extension, and - a sliding sleeve configured to slide within the tubular part between a first position covering the opening and a second position fully uncovering the opening, the tubular part comprising a first groove and a second groove , the first groove being arranged at a first distance (di) from the second groove along the axial extension, and the sliding sleeve comprising a projecting part configured to engage the first groove in the first position and the second groove in the second position, characterised in that the tubular part comprises a third groove configured to be engaged by the projecting part and having a second distance (d 2 ) to the second groove which is smaller than the first distance, wherein the first groove , the second groove and the third groove are arranged in order so that the first groove is arranged next to the second groove , and the third groove is arranged next to the second groove along the axial extension.
A denesting apparatus , the apparatus comprising: One or more closed loop conveying tracks , each closed loop conveying track comprising a plurality of sets of one or more de-stacking means movingly configured thereon through one or more de-stacking means moving mechanism ; one or more stacking magazines , each adapted to hold a stack of sheets supported thereon; wherein each of the plurality of sets of de-stacking means is adapted to selectively engage an uppermost sheet from at least one of the one or more stacking magazines in any desired order either sequentially or simultaneously so as to discharge the picked-up sheets onto an out-feed conveyor in any desired manner either one besides another or otherwise one overlapping the other. One or more closed loop conveying tracks , each closed loop conveying track comprising a plurality of sets of one or more de-stacking means movingly configured thereon through one or more de-stacking means moving mechanism ; one or more stacking magazines , each adapted to hold a stack of sheets supported thereon; wherein each of the plurality of sets of de-stacking means is adapted to selectively engage an uppermost sheet from at least one of the one or more stacking magazines in any desired order either sequentially or simultaneously so as to discharge the picked-up sheets onto an out-feed conveyor in any desired manner either one besides another or otherwise one overlapping the other.
A compartment of a railway vehicle defining an interior volume and comprising: - a cover , movable between an open position, in which the cover is offset from the interior volume , and a closed position, in which the cover covers the interior volume and at least partially delimits said interior volume , - a bar , a central region of the bar extending out of the interior volume , and - a hinge defining the path of the cover between the open and closed positions, the cover is rotatable about an axis (A-A) of the bar between its open and closed position, the bar forming a pin of the hinge , characterized in that , an upper region and a lower region of the bar extend into the interior volume , the bar passing through the cover between its lower region and its central region and between its upper region and its central region . - a cover , movable between an open position, in which the cover is offset from the interior volume , and a closed position, in which the cover covers the interior volume and at least partially delimits said interior volume , - a bar , a central region of the bar extending out of the interior volume , and - a hinge defining the path of the cover between the open and closed positions, the cover is rotatable about an axis (A-A) of the bar between its open and closed position, the bar forming a pin of the hinge , characterized in that , an upper region and a lower region of the bar extend into the interior volume , the bar passing through the cover between its lower region and its central region and between its upper region and its central region .
A cassette for generating a continuous liquid film from supplied biological liquid , suitable for irradiation of the generated liquid film and continuous inactivation of pathogens in the biological liquid in a continuous dose-controlled irradiation assembly with a module housing containing: Tub for receiving the liquid , feed channel for feeding the liquid into the tub , cylindrical roller which is immersed in the tub and liquid and is rotatable there, wiper lip on the outgoing side of the roller in tight contact with the roller surface for wiping off the liquid film formed on the rotating roller surface during rotation of the roller , and a discharge channel for receiving and discharging liquid wiped off by the wiper lip , and with a housing cover for tightly closing the module housing , characterized in that the housing cover has a gas- and liquid-tight metal window which is permeable to beta radiation, in that the module housing includes an overflow channel for draining excess liquid from the tub to establish a liquid level in the tub , and in that the cassette, is sterilisable and replaceable for recurrent use on the continuous dose controlled irradiation assembly. with a module housing containing: Tub for receiving the liquid , feed channel for feeding the liquid into the tub , cylindrical roller which is immersed in the tub and liquid and is rotatable there, wiper lip on the outgoing side of the roller in tight contact with the roller surface for wiping off the liquid film formed on the rotating roller surface during rotation of the roller , and a discharge channel for receiving and discharging liquid wiped off by the wiper lip , and Tub for receiving the liquid , feed channel for feeding the liquid into the tub , cylindrical roller which is immersed in the tub and liquid and is rotatable there, wiper lip on the outgoing side of the roller in tight contact with the roller surface for wiping off the liquid film formed on the rotating roller surface during rotation of the roller , and a discharge channel for receiving and discharging liquid wiped off by the wiper lip , and with a housing cover for tightly closing the module housing , characterized in that the housing cover has a gas- and liquid-tight metal window which is permeable to beta radiation, in that the module housing includes an overflow channel for draining excess liquid from the tub to establish a liquid level in the tub , and in that the cassette, is sterilisable and replaceable for recurrent use on the continuous dose controlled irradiation assembly. characterized in that the housing cover has a gas- and liquid-tight metal window which is permeable to beta radiation, in that the module housing includes an overflow channel for draining excess liquid from the tub to establish a liquid level in the tub , and in that the cassette, is sterilisable and replaceable for recurrent use on the continuous dose controlled irradiation assembly.
Method for producing an immunoglobulin single variable domain in a yeast, comprising A) applying conditions that promote the formation of disulfide bridges in immunoglobulin single variable domains, or B) removing immunoglobulin single variable domains lacking at least one disulfide bridge by applying conditions selected from i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or C) a combination of (A) and (B), wherein the conditions that promote the formation of disulfide bridges are selected from one or more of the following: a) addition of oxidizing metal ions to at least one production step selected from: the culture broth after fermentation, the supernatant comprising the immunoglobulin single variable domain after removal of the host, any step after purification of the immunoglobulin single variable domain, or the purified immunoglobulin single variable domain or b) addition of Cu2+ to a final concentration of 1 to 10 mM. A) applying conditions that promote the formation of disulfide bridges in immunoglobulin single variable domains, or B) removing immunoglobulin single variable domains lacking at least one disulfide bridge by applying conditions selected from i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or i) binding immunoglobulin single variable domains comprising free thiol groups to immobilized thiol groups, optionally under denaturing conditions; and ii) reverse phase high performance chromatography, or C) a combination of (A) and (B), a) addition of oxidizing metal ions to at least one production step selected from: the culture broth after fermentation, the supernatant comprising the immunoglobulin single variable domain after removal of the host, any step after purification of the immunoglobulin single variable domain, or the purified immunoglobulin single variable domain or b) addition of Cu2+ to a final concentration of 1 to 10 mM.
A cell sorting system comprising a cell sorting valve microfabricated on a surface of a silicon substrate, with microfabricated channels leading from the cell sorting valve, wherein the cell sorting valve separates the target particles from non-target material by directing the target particles from a sample channel into a sort channel formed in the silicon substrate and the non-target material from the sample channel to a waste output channel also formed in the silicon substrate; a disposable cartridge containing a sample reservoir , a sort reservoir and a waste reservoir ; and an interposer that provides fluid communication between the microfabricated channels in the silicon substrate and the reservoirs in the disposable cartridge , wherein the interposer provides a sort fluid path between a sort reservoir in the disposable cartridge and the sort channel in the silicon substrate, a waste fluid path between a waste reservoir in the disposable cartridge and the waste channel , and a sample fluid path between the sample channel and a sample reservoir characterized in that the channel geometries at the interfaces of the interposer to the silicon substrate and/or the disposable cartridge are designed in way that channel diameters are always increasing in flow direction.
A crosslinked polyolefin separator having an average value of light transmittance of 30% or more in a region of 380 nm to 700 nm, after four sides of the separator are fixed and allowed to stand at 130°C for 30 minutes, the light transmittance being measured as described in the specification, wherein the crosslinked polyolefin separator has 0.5-10 grafted units based on 1000 carbon atoms in the polyolefin backbone forming the crosslinked polyolefin separator as measured as described in the specification, and the grafted units are silane-grafted units. the crosslinked polyolefin separator has 0.5-10 grafted units based on 1000 carbon atoms in the polyolefin backbone forming the crosslinked polyolefin separator as measured as described in the specification, and the grafted units are silane-grafted units.
A medium additive composition comprising a compound represented by the following formula (I), or a salt thereof: {wherein, X is a single bond, -CH 2 COO-, -CONH-, or -NHCO-, R 1 is an alkyl group having 1 - 10 carbon atoms, an aryl group, or -Y-W-Z-Ar wherein Y and Z are each a single bond or an alkylene group having 1 - 6 carbon atoms, W is an oxygen atom, a sulfur atom or N(R 4 ), R 4 is a hydrogen atom or an alkyl group having 1 - 6 carbon atoms, Ar is an aryl group optionally having substituent(s), R 2 is an alkyl group having 1 - 6 carbon atoms, R 3 is a hydroxyl group, and n is 0, 1 or 2}, wherein when Ar has substituent(s) the substituent(s) are selected from halogeno groups and hydroxyl groups.
An effective amount of X4P-001 or a pharmaceutically acceptable salt or composition thereof for use in the treatment of WHIM syndrome in a patient.
A microfluidic system for fluid specimen collection, especially blood, by means of capillary forces, and separation thereof by centrifugation about an axis of rotation of a centrifuge rotor, comprising: a. the first chamber and the second chamber , wherein these chambers are directly hydraulically interconnected by a constriction ; b. a capillary aspiration channel leading to the first chamber , wherein the inlet of the channel is a hole in the external surface of the system; c. a vent channel whose first end is a different hole in the external surface of the system; wherein said elements of the microfluidic system are placed so in this system that after placing the microfluidic system in the centrifuge rotor for centrifugation, the inlet of the capillary aspiration channel and the first end of the vent channel are located closer to the axis of rotation, the first chamber is located further away from the axis of rotation, and the second chamber is furthest away from the axis of rotation; characterised in that the second end of the vent channel is directly interconnected with the capillary aspiration channel inside the microfluidic system, in the section between the inlet of the aspiration channel and the first chamber , wherein the first chamber is structurally adapted so that it can be accessed by means of a standard tip for specimen collection, and that it is possible to collect the content from the inside of the first chamber , and in that the microfluidic system comprises an excess chamber to accommodate the excess fluid, connected to the capillary aspiration channel in the section of the capillary aspiration channel between the first chamber and the second end of the vent channel . a. the first chamber and the second chamber , wherein these chambers are directly hydraulically interconnected by a constriction ; b. a capillary aspiration channel leading to the first chamber , wherein the inlet of the channel is a hole in the external surface of the system; c. a vent channel whose first end is a different hole in the external surface of the system;
An air conditioning system , which comprises an outdoor subsystem, an indoor subsystem and a power module for driving a cooling medium, the outdoor subsystem is configured with a plurality of parallel branches and said branches comprise a branch inlet and a branch outlet, wherein the cooling medium flows into the indoor subsystem through the power module and the outdoor subsystem, performs heat exchange with the indoor air in an indoor unit of the indoor subsystem, and subsequently returns to an outdoor unit of the outdoor subsystem through the power module for heat exchange, thereby forming a circulation of the cooling medium, characterized in that : each branch is configured with an outdoor unit and a first control valve , the air conditioning system further comprises a controller , a first pressure sensor for measuring the pressure at the branch inlet and a second pressure sensor for measuring the pressure at the branch outlet, the controller comprises a first pressure difference determination module that communicates with the first pressure sensor and the second pressure sensor, and a first control module of the first pressure difference that communicates with the first pressure difference determination module and the first control valve, wherein the first pressure difference determination module receives the pressure at the branch inlet and the pressure at the branch outlet from the first pressure sensor and the second pressure sensor, and determines the pressure difference between the outlet and the inlet of the branches.
A method for securing an infrastructure in a computer network against malicious attacks, comprising: - receiving network session information from at least one computing device over a computer network, the network session information containing computing instructions to be performed in a requested infrastructure; - scanning the requested infrastructure and emulating the requested infrastructure; - executing a duplicated network session information using the emulated infrastructure and recording the execution of the computing instructions in said emulated infrastructure, wherein the duplicated network session information is assigned a new identifier and the duplicated network session information is addressed using the new identifier and the original network session information remains in a secured area and is left unused; - storing the duplicated network session and the execution of the computing instructions as a signature information and comparing this signature information with previously established signature information, the previously established signature information being stored as a function of data transmissions from several computing devices and data transmissions to several requested infrastructures, thereby computing a security index; and - executing the computing instructions in the requested infrastructure as a function of the security index. - receiving network session information from at least one computing device over a computer network, the network session information containing computing instructions to be performed in a requested infrastructure; - scanning the requested infrastructure and emulating the requested infrastructure; - executing a duplicated network session information using the emulated infrastructure and recording the execution of the computing instructions in said emulated infrastructure, wherein the duplicated network session information is assigned a new identifier and the duplicated network session information is addressed using the new identifier and the original network session information remains in a secured area and is left unused; - storing the duplicated network session and the execution of the computing instructions as a signature information and comparing this signature information with previously established signature information, the previously established signature information being stored as a function of data transmissions from several computing devices and data transmissions to several requested infrastructures, thereby computing a security index; and - executing the computing instructions in the requested infrastructure as a function of the security index.