mhurhangee/patent-ind-claim-en huggingface dataset:
A double stranded nucleic acid (dsNA) comprising: a sense strand comprising 21 to 83 nucleotides; an antisense strand comprising 15 to 39 nucleotides; a duplex formed by said sense and antisense strand, having a length of 15 to 35 base pairs; wherein the dsNA comprises a discontinuity between the 5'-terminus of the sense strand and the 3'-terminus of the antisense strand or between the 3'-terminus of the sense strand and the 5'-terminus of the antisense strand; wherein the sense strand comprises a tetraloop and the tetraloop comprises at least one ligand conjugated nucleotide; wherein each ligand is conjugated to a nucleotide of the tetraloop via an acetal linker and wherein said antisense strand is complementary to a target mRNA along at least 15 nucleotides of said antisense strand and said dsNA reduces target gene expression when introduced into a mammal or a mammalian cell. a sense strand comprising 21 to 83 nucleotides; an antisense strand comprising 15 to 39 nucleotides; a duplex formed by said sense and antisense strand, having a length of 15 to 35 base pairs; wherein the dsNA comprises a discontinuity between the 5'-terminus of the sense strand and the 3'-terminus of the antisense strand or between the 3'-terminus of the sense strand and the 5'-terminus of the antisense strand; wherein the sense strand comprises a tetraloop and the tetraloop comprises at least one ligand conjugated nucleotide; wherein each ligand is conjugated to a nucleotide of the tetraloop via an acetal linker and wherein said antisense strand is complementary to a target mRNA along at least 15 nucleotides of said antisense strand and said dsNA reduces target gene expression when introduced into a mammal or a mammalian cell.
A forward osmosis membrane wherein a thin membrane layer exhibiting semi-permeable membrane performance is laminated on a polyketone support layer, wherein the polyketone support layer has pores with a maximum pore size of 50 nm or greater and no greater than 2 μm, as measured by the bubble point method according to JIS K3832, characterized in that the polyketone support layer is made of a copolymer of carbon monoxide and an olefin, the polyketone includes repeating units of 1-oxotrimethylene represented by the following formula , -CH 2 -CH 2 -C(=O)- wherein the proportion of 1-oxotrimethylene repeating units among the repeating units of the polyketone is 70 mol% or greater, the porosity of the polyketone support layer, determined as described in the description, is 70% or greater, the polyketone support layer is a flat membrane polyketone support layer having a thickness of no greater than 200 μm or a hollow fiber polyketone support layer having a thickness of 10 to 200 μm, and wherein the thin membrane layer exhibiting semi-permeable membrane performance is a polyamide thin membrane layer with a thickness of 0.05 to 2 μm.
Compound 2250 or a pharmaceutically acceptable salt, hydrate, ester, or solvate thereof, for use in a method of treating a cytokine release syndrome (CRS) or a cytokine storm in a subject.
A compound, or a pharmaceutically acceptable salt thereof, having the structure of formula (II): wherein: R 1 is -OH, -OR 4 , -NHOR 5 , -NHSO 2 R 4 , -NR 4 R 5 or R 4 ; or -C(=O)R 1 is a carboxylic acid bioisostere having the structure Ring A is monocyclic 5- or 6-membered heteroaryl; L 2 is absent, -O-(CH 2 )-, or -S-(CH 2 )-; R 2 is hydrogen, halogen, nitro, -CN, -OH, -OR 4 , C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; n is 0, 1, 2, 3, or 4; R 3 is C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 3 -C 6 cycloalkyl, or aryl; X is -OH, -OR 4 , halogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; Z is -OH, -OR 4 , halogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; R 4 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, or heteroaryl; R 5 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 3 -C 6 cycloalkyl, or aryl; or R 4 and R 5 taken together with the nitrogen to which they are attached to form a C 2 -C 8 heterocycloalkyl. R 1 is -OH, -OR 4 , -NHOR 5 , -NHSO 2 R 4 , -NR 4 R 5 or R 4 ; or -C(=O)R 1 is a carboxylic acid bioisostere having the structure Ring A is monocyclic 5- or 6-membered heteroaryl; L 2 is absent, -O-(CH 2 )-, or -S-(CH 2 )-; R 2 is hydrogen, halogen, nitro, -CN, -OH, -OR 4 , C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; n is 0, 1, 2, 3, or 4; R 3 is C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 3 -C 6 cycloalkyl, or aryl; X is -OH, -OR 4 , halogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; Z is -OH, -OR 4 , halogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; R 4 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, aryl, or heteroaryl; R 5 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 3 -C 6 cycloalkyl, or aryl; or R 4 and R 5 taken together with the nitrogen to which they are attached to form a C 2 -C 8 heterocycloalkyl.
A method of suspending elemental sulfur in water, said method comprising the steps of: A. providing water comprising elemental sulfur and hydrogen sulfide; and, B. adding from 1 to 100 parts by weight of a sulfur suspension additive to the water based on one million parts by weight of the water to suspend the elemental sulfur in the water, wherein the sulfur suspension additive is: either an alkyldiphenyloxide disulfonate or salt thereof; or, a combination of an alkyldiphenyloxide disulfonate or salt thereof with a secondary alcohol ethoxylate, a non-ionic ethylene oxide and/or propylene oxide copolymer or both of a secondary alcohol ethoxylate and a non-ionic ethylene oxide and/or propylene oxide copolymer. A. providing water comprising elemental sulfur and hydrogen sulfide; and, B. adding from 1 to 100 parts by weight of a sulfur suspension additive to the water based on one million parts by weight of the water to suspend the elemental sulfur in the water, either an alkyldiphenyloxide disulfonate or salt thereof; or, a combination of an alkyldiphenyloxide disulfonate or salt thereof with a secondary alcohol ethoxylate, a non-ionic ethylene oxide and/or propylene oxide copolymer or both of a secondary alcohol ethoxylate and a non-ionic ethylene oxide and/or propylene oxide copolymer.
A data processing apparatus, comprising: a signal quality determination module trained to determine signal qualities of intravascular electrocardiogram, ECG, signals from a tip of a catheter inserted in a paediatric patient, the signal quality determination module receiving, as input, a frequency response of the intravascular ECG signals, the frequency response obtained by performing a fast Fourier transform, FFT, on a sample of the intravascular ECG signals; and a location determination module trained to determine a relative location of the tip of the catheter in the paediatric patient using P-wave and R-wave peaks extracted from the intravascular ECG signals, the location determination module being previously trained using a set of pre-recorded intravascular ECG tracings obtained from catheters and labelled with the known locations of the catheters in paediatric patients' bodies; wherein the signal quality determination module is configured to pass the intravascular ECG signals to the location determination module if they are determined to have an adequate signal quality and is configured to trigger an alert to an operator if they are determined to have an inadequate signal quality. a signal quality determination module trained to determine signal qualities of intravascular electrocardiogram, ECG, signals from a tip of a catheter inserted in a paediatric patient, the signal quality determination module receiving, as input, a frequency response of the intravascular ECG signals, the frequency response obtained by performing a fast Fourier transform, FFT, on a sample of the intravascular ECG signals; and a location determination module trained to determine a relative location of the tip of the catheter in the paediatric patient using P-wave and R-wave peaks extracted from the intravascular ECG signals, the location determination module being previously trained using a set of pre-recorded intravascular ECG tracings obtained from catheters and labelled with the known locations of the catheters in paediatric patients' bodies; wherein the signal quality determination module is configured to pass the intravascular ECG signals to the location determination module if they are determined to have an adequate signal quality and is configured to trigger an alert to an operator if they are determined to have an inadequate signal quality.
An integrated fuel and environmental control system , comprising: a first heat exchanger in which fuel and oil thermally communicate; and comprising a second heat exchanger disposable in a super-cooled fluid flow, wherein the heat exchangers are in fluid communication with respective fluid flows; and a first control system to control relative amounts of the fuel and the oil from the first heat exchanger to be received by the second heat exchanger, and the second heat exchanger being receptive of: the relative amount of the oil and the relative amount of the fuel from the first heat exchanger whereby the relative amount of the oil and the relative amount of the fuel thermally communicate with the super-cooled fluid flow, and a second fluid whereby the second fluid thermally communicates with the super-cooled fluid flow downstream from the thermal communication of the super-cooled fluid flow with the relative amount of the oil and the relative amount of the fuel. a first heat exchanger in which fuel and oil thermally communicate; and comprising a second heat exchanger disposable in a super-cooled fluid flow, wherein the heat exchangers are in fluid communication with respective fluid flows; and a first control system to control relative amounts of the fuel and the oil from the first heat exchanger to be received by the second heat exchanger, and the second heat exchanger being receptive of: the relative amount of the oil and the relative amount of the fuel from the first heat exchanger whereby the relative amount of the oil and the relative amount of the fuel thermally communicate with the super-cooled fluid flow, and a second fluid whereby the second fluid thermally communicates with the super-cooled fluid flow downstream from the thermal communication of the super-cooled fluid flow with the relative amount of the oil and the relative amount of the fuel. the relative amount of the oil and the relative amount of the fuel from the first heat exchanger whereby the relative amount of the oil and the relative amount of the fuel thermally communicate with the super-cooled fluid flow, and a second fluid whereby the second fluid thermally communicates with the super-cooled fluid flow downstream from the thermal communication of the super-cooled fluid flow with the relative amount of the oil and the relative amount of the fuel.
Electrolyte-based field effect transistor comprising: - a dielectric layer (OX); - a source electrode (S) and a drain electrode (D) located on top of the dielectric layer (OX); the electrolyte-based transistor being characterized in that it comprises: - a lithium-based solid-state electrolyte layer (EC) between and on top of the source electrode (S) and the drain electrode (D), the part of the electrolyte layer (EC) located between the source electrode (S) and the drain electrode (D) being in direct contact with the dielectric layer (OX); - a gate electrode (G) on top of the electrolyte layer (EC) and in direct contact with the electrolyte layer (EC), the orthogonal projection of said gate electrode (EC) in a plane comprising the source (S) and drain (D) electrodes being located, at least in part, between the source (S) and the drain (D) electrodes. - a dielectric layer (OX); - a source electrode (S) and a drain electrode (D) located on top of the dielectric layer (OX); - a lithium-based solid-state electrolyte layer (EC) between and on top of the source electrode (S) and the drain electrode (D), the part of the electrolyte layer (EC) located between the source electrode (S) and the drain electrode (D) being in direct contact with the dielectric layer (OX); - a gate electrode (G) on top of the electrolyte layer (EC) and in direct contact with the electrolyte layer (EC), the orthogonal projection of said gate electrode (EC) in a plane comprising the source (S) and drain (D) electrodes being located, at least in part, between the source (S) and the drain (D) electrodes.
A method for densifying porous annular substrates by chemical vapor infiltration, the method comprising at least the following steps: - providing a plurality of unit modules , each unit module comprising a support tray on which porous annular substrates are stacked, the support tray comprising a gas intake opening extended by an injection tube disposed in an internal volume formed by the central passages of the stacked substrates, the injection tube comprising a first end connected to the tray, a second free end and gas injection orifices opening into the internal volume, - forming stacks of unit modules in the enclosure of a densification furnace, each stack comprising at least a second unit module stacked on a first unit module, the intake opening of the support tray of the second unit module communicating with the free end of the injection tube of the second unit module so as to allow the circulation of a gas between the first and the second module, and - injecting, into the stacks of unit modules, a gas phase comprising a gas precursor of a matrix material to be deposited within the porosity of the substrates. - providing a plurality of unit modules , each unit module comprising a support tray on which porous annular substrates are stacked, the support tray comprising a gas intake opening extended by an injection tube disposed in an internal volume formed by the central passages of the stacked substrates, the injection tube comprising a first end connected to the tray, a second free end and gas injection orifices opening into the internal volume, - forming stacks of unit modules in the enclosure of a densification furnace, each stack comprising at least a second unit module stacked on a first unit module, the intake opening of the support tray of the second unit module communicating with the free end of the injection tube of the second unit module so as to allow the circulation of a gas between the first and the second module, and - injecting, into the stacks of unit modules, a gas phase comprising a gas precursor of a matrix material to be deposited within the porosity of the substrates.
Securing device for securing a door in escape and rescue routes, preferably a fire door or smoke-protective door, having at least one door leaf constructed as a stop swivel leaf, which is pivotably mounted using hinges onto a stationary door frame , having a door actuator constructed as a door closure device with a closing spring , said door actuator having an actuator housing and a driveshaft mounted within it, which works together with a force-transmitting linkage arranged between the door leaf and the stationary door frame , preferably a scissor arm linkage or sliding arm linkage, such that the door actuator biases the door leaf in the direction of its closed position, having an RWS terminal arranged in the region of the door with an emergency button , and having a locking device switchable by the emergency button , said locking device electronically switchably locking and/or unlocking the door leaf in its closed position, characterised in that the door closure device has an electrically switchable freewheel device which switchably prevents and/or releases a force transmission of the closing spring onto the linkage at least in a closing direction and/or an opening direction, and having a control device which is connected to the switchable locking device , and the switchable freewheel device and is designed in such a way that it separately switches the locking device and the switchable freewheel device .
An interlayer film for laminated glass, comprising: a first resin layer containing a thermoplastic resin and a plasticizer; and a second resin layer containing a thermoplastic resin, a plasticizer and inorganic particles, and the first resin layer being arranged on a first surface side of the second resin layer, wherein a dark color part where the parallel light transmittance is less than or equal to 30% at the time of preparing the laminated glass with two sheets of clear glass in accordance with JIS R3202 exists, the minimum value of the total light transmittance in a portion of the dark color part of the laminated glass being greater than or equal to 50%, a gradation part being a region where the parallel light transmittance is greater than 30% and less than 60% and being a region where the thickness of the second resin layer is continuously decreased in the direction orthogonal to the thickness direction of the interlayer film at the time of preparing the laminated glass with two sheets of clear glass in accordance with JIS R3202 exists, and the complex viscosity at 200°C of the second resin layer is greater than or equal to 0.7 times and less than or equal to 2 times the complex viscosity at 200°C of the first resin layer, the complex viscosities being measured according to the method in the description. a first resin layer containing a thermoplastic resin and a plasticizer; and a second resin layer containing a thermoplastic resin, a plasticizer and inorganic particles, and the first resin layer being arranged on a first surface side of the second resin layer, wherein a dark color part where the parallel light transmittance is less than or equal to 30% at the time of preparing the laminated glass with two sheets of clear glass in accordance with JIS R3202 exists, the minimum value of the total light transmittance in a portion of the dark color part of the laminated glass being greater than or equal to 50%, a gradation part being a region where the parallel light transmittance is greater than 30% and less than 60% and being a region where the thickness of the second resin layer is continuously decreased in the direction orthogonal to the thickness direction of the interlayer film at the time of preparing the laminated glass with two sheets of clear glass in accordance with JIS R3202 exists, and the complex viscosity at 200°C of the second resin layer is greater than or equal to 0.7 times and less than or equal to 2 times the complex viscosity at 200°C of the first resin layer, the complex viscosities being measured according to the method in the description.
Harness for attachment to a person to be secured, in particular climbing harness or personal protective equipment, comprising a hip belt , a leg belt and an attachment point , wherein the leg belt comprises two leg loops each with two loop ends , the two loop ends each pass over into a leg connection portion extending between two opposite ends such that two loop ends are arranged at each end so that the leg connection portion connects the leg loops with each other, and the hip belt and the leg connection portion are connected to each other at the attachment point such that the attachment point is disposed between the leg loops ; characterized in that the loop ends belonging to one leg loop are interwoven between the two ends in order to form the leg connection portion . the leg belt comprises two leg loops each with two loop ends , the two loop ends each pass over into a leg connection portion extending between two opposite ends such that two loop ends are arranged at each end so that the leg connection portion connects the leg loops with each other, and the hip belt and the leg connection portion are connected to each other at the attachment point such that the attachment point is disposed between the leg loops ; characterized in that the loop ends belonging to one leg loop are interwoven between the two ends in order to form the leg connection portion .
A fluid suction nozzle that includes a nozzle housing , the nozzle housing having a suction passage that communicates with a vacuum source for generating a suction flow; the nozzle housing includes a head portion ; the head portion is provided with a first squeegee and a second squeegee , and a suction inlet communicating with the suction passage is formed between the first squeegee and the second squeegee , wherein at least one end of the first squeegee and the second squeegee protrudes outward from the boundary of the head portion along the extension direction of a first axis (N), wherein the side edges of the first squeegee and/or the second squeegee form an angle α with the vertical direction, characterised in that the angle α = 10°.
A seal jaw for use in packaging a product comprising: a first sealing bar ; a second sealing bar ; and a servo motor for controlling movement of at least one of the first and the second sealing bars between an open position and a closed position where the first and second sealing bars are in contact; characterised in that a pneumatic cylinder is connected with at least one of the first and second sealing bars and is configured to control a pressure between the first and the second sealing bars when in the closed position. a first sealing bar ; a second sealing bar ; and a servo motor for controlling movement of at least one of the first and the second sealing bars between an open position and a closed position where the first and second sealing bars are in contact; characterised in that a pneumatic cylinder is connected with at least one of the first and second sealing bars and is configured to control a pressure between the first and the second sealing bars when in the closed position.
A light source module for a microscope , comprising: a light source unit configured to emit illumination light along an illumination light path , at least one light blocking shutter configured to be moved into and out of the illumination light path , and at least one light sensor configured to detect an intensity of the illumination light propagating along the illumination light path , wherein the at least one light sensor is integrated with the at least one light blocking shutter to be moved therewith into and out of the illumination light path . a light source unit configured to emit illumination light along an illumination light path , at least one light blocking shutter configured to be moved into and out of the illumination light path , and at least one light sensor configured to detect an intensity of the illumination light propagating along the illumination light path , wherein the at least one light sensor is integrated with the at least one light blocking shutter to be moved therewith into and out of the illumination light path .
A composition comprising a chimeric peptide, the chimeric peptide comprising an orthopoxvirus major histocompatibility complex class 1-like protein (OMCP) peptide linked to an IL2 peptide, wherein the OMCP peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOS: 7, 13, and 14, and the IL2 peptide comprises an amino acid sequence of SEQ ID NO: 5 or SEQ ID NO: 5 with at least one mutation, wherein said at least one mutation is selected from the group consisting of R38A, F42K, and C125S.
Substrate element for use in an artificial grass pitch, the substrate element comprising a substrate body and a plurality of protuberances integrally formed with said substrate body, whereby the protuberances are evenly distributed across one of its surfaces and extending therefrom at a density of between 0.1 and 8 protuberances per square centimetre, and whereby the protuberances have a length of between 5 mm and 15 mm, characterised in that the substrate element has a hardness of between 30 Sh(A) and 70 Sh(A) and in that the protuberances are elongate, having a length greater than their width, whereby the protuberances are collapsible and can absorb energy by collapsing from an upright position to a bent position when subjected to an axial load.