A microscope comprising: a sample holder configured to receive a sample and having a light transparent portion ; a first illumination objective arranged to eject a first illumination light beam along a first illumination path to illuminate the sample received by the sample holder through the light transparent portion of the sample holder such that light is ejected from the sample ; a second illumination objective arranged to eject a second illumination light beam along a second illumination path to illuminate the sample received by the sample holder through the light transparent portion of the sample holder such that light is ejected from the sample ; a first imaging objective arranged to receive detection light comprising at least a portion of the light ejected from the sample , wherein the detection light is propagated along a first detection path angled at about 90° to the first and second illumination paths and wherein the first imaging objective has a first imaging focal plane ; a second imaging objective arranged to receive detection light comprising at least a portion of the light ejected from the sample, wherein the detection light is propagated along a second detection path angled at about 90° to the first and second illumination paths and wherein the second imaging objective has a second imaging focal plane ; and a holder support arranged to support the sample holder , characterized by , relative to a direction of gravity , the first and second illumination objectives are arranged such that the first and second illumination path are located below a bottom of the sample holder , and wherein the first and second illumination paths are not parallel, and wherein the holder support has a drive system arranged to displace the sample holder along two perpendicular axes (X, Y) relative to the first and second imaging objectives . a sample holder configured to receive a sample and having a light transparent portion ; a first illumination objective arranged to eject a first illumination light beam along a first illumination path to illuminate the sample received by the sample holder through the light transparent portion of the sample holder such that light is ejected from the sample ; a second illumination objective arranged to eject a second illumination light beam along a second illumination path to illuminate the sample received by the sample holder through the light transparent portion of the sample holder such that light is ejected from the sample ; a first imaging objective arranged to receive detection light comprising at least a portion of the light ejected from the sample , wherein the detection light is propagated along a first detection path angled at about 90° to the first and second illumination paths and wherein the first imaging objective has a first imaging focal plane ; a second imaging objective arranged to receive detection light comprising at least a portion of the light ejected from the sample, wherein the detection light is propagated along a second detection path angled at about 90° to the first and second illumination paths and wherein the second imaging objective has a second imaging focal plane ; and a holder support arranged to support the sample holder , characterized by , relative to a direction of gravity , the first and second illumination objectives are arranged such that the first and second illumination path are located below a bottom of the sample holder , and wherein the first and second illumination paths are not parallel, and wherein the holder support has a drive system arranged to displace the sample holder along two perpendicular axes (X, Y) relative to the first and second imaging objectives . <EOS>