mhurhangee/patent-ind-claim-en huggingface dataset:
An activatable antibody (AA) comprising: an antibody or antibody fragment (AB) which antibody or fragment (AB) binds to a target which is EGFR, wherein the AB comprises (i) the variable region of the heavy chain amino acid sequence of SEQ ID NO: 222 and (ii) the variable region of the light chain amino acid sequence of SEQ ID NO: 230, a masking moiety (MM) that inhibits the specific binding of the AB of the AA in an uncleaved state to the target, wherein: (A) the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and (B) the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); a cleavable moiety (CM), wherein the CM is a polypeptide that functions as a substrate for a uPA protease, wherein the CM comprises the amino acid sequence selected from the group consisting of: TGRGPSWV (SEQ ID NO: 267), LSGRSDNH (SEQ ID NO: 270), and PLTGRSGG (SEQ ID NO: 273); and linker moieties L1 coupling the MM to the CM and L2 coupling the CM to the AB, wherein the AA in the uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: (MM)-L1-(CM)-L2-(AB), wherein L2 links the CM to the N-terminal light chain of the AB, and wherein the L1 and L2 are each flexible linkers comprising glycine or glycine and serine. an antibody or antibody fragment (AB) which antibody or fragment (AB) binds to a target which is EGFR, wherein the AB comprises (i) the variable region of the heavy chain amino acid sequence of SEQ ID NO: 222 and (ii) the variable region of the light chain amino acid sequence of SEQ ID NO: 230, a masking moiety (MM) that inhibits the specific binding of the AB of the AA in an uncleaved state to the target, wherein: (A) the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and (B) the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); (A) the MM does not interfere or compete with the AB for binding to the target when the activatable antibody is in a cleaved state, and (B) the MM comprises the amino acid sequence selected from the group consisting of CISPRGCPDGPYVM (SEQ ID NO: 218), CISPRGCEPGTYVPT (SEQ ID NO: 219), and CISPRGCPGQIWHPP (SEQ ID NO: 220); a cleavable moiety (CM), wherein the CM is a polypeptide that functions as a substrate for a uPA protease, wherein the CM comprises the amino acid sequence selected from the group consisting of: TGRGPSWV (SEQ ID NO: 267), LSGRSDNH (SEQ ID NO: 270), and PLTGRSGG (SEQ ID NO: 273); and linker moieties L1 coupling the MM to the CM and L2 coupling the CM to the AB, wherein the AA in the uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: (MM)-L1-(CM)-L2-(AB), wherein L2 links the CM to the N-terminal light chain of the AB, and wherein the L1 and L2 are each flexible linkers comprising glycine or glycine and serine.
A positive electrode plate comprising a current collector, a positive active material layer and a safety coating disposed between the current collector and the positive active material layer, and wherein the safety coating comprises a polymer matrix, a conductive material and an inorganic filler and wherein when the safety coating and the positive active material layer are collectively referred as a film layer, the film layer has an elongation of 30% or more and wherein the polymer matrix of the safety coating is fluorinated polyolefin and/or chlorinated polyolefin having a crosslinked structure, wherein the elongation is determined according to the teaching of the description.
System product for the protective treatment of mineral surfaces, plastics with porous surfaces, microporous floors and floor materials, i.e. floors and floor materials with pores in the micrometer range, such as parquet, wood of all kinds, linoleum, rubber/rubber, PVC, polyurethane, epoxy, natural stones, limestone, concrete, anhydrite, cement filler and others, in the form of a water-dilutable lacquer, consisting of at least two components A and B with three basic components, namely A a water-dilutable two-component epoxy primer, and B of an aqueous polymer dispersion having a pH between 6 and 9 and an emulsifiable isocyanate resin, where component B is free from polysiloxanes. A a water-dilutable two-component epoxy primer, and B of an aqueous polymer dispersion having a pH between 6 and 9 and an emulsifiable isocyanate resin,
System for illuminating the face of an occupant for a video call in a car , comprising at least one light source featuring a color temperature range of 2700K to 5000K, the light source having a main light emission direction (A) which is directed to the face of the occupant , wherein the system comprises a camera , and the camera is provided to record the face of the occupant , whereas the system is performed to control the light source in such a way to obtain a flickering free recording of the face of the occupant , and wherein the system provides a control unit , which control unit is connected to the light source and provides pulsed operating (LP) to control the light source , characterized in that the control unit is programmed to provide at least two different illumination modes for the face of the occupant : - a private video call mode, whereby the light source generates a warm color tone, and - a business video call mode, whereby the light source generates a less warm color tone compared to the private video call mode. - a private video call mode, whereby the light source generates a warm color tone, and - a business video call mode, whereby the light source generates a less warm color tone compared to the private video call mode.
A receiver optical sub-assembly , comprising a first transistor-outline can , wherein the first transistor-outline can comprises a header and a cap disposed on the header , a light incident hole is disposed on the first transistor-outline can , a first demultiplexer , a first optical receiver , a second optical receiver , and an optical lens combination are disposed inside the cap , and the first optical receiver and the second optical receiver are connected to the header ; light enters the first demultiplexer through the light incident hole , and the first demultiplexer is configured to transmit an optical signal of a first wavelength and reflect an optical signal of a second wavelength; the first optical receiver is disposed on a transmission optical path of the first demultiplexer , and the first optical receiver is configured to receive the optical signal of the first wavelength; the optical lens combination is disposed on a reflection optical path of the first demultiplexer , the optical lens combination is configured to guide, to the second optical receiver , the optical signal of the second wavelength that is reflected by the first demultiplexer , and the second optical receiver is configured to receive the optical signal of the second wavelength. light enters the first demultiplexer through the light incident hole , and the first demultiplexer is configured to transmit an optical signal of a first wavelength and reflect an optical signal of a second wavelength; the first optical receiver is disposed on a transmission optical path of the first demultiplexer , and the first optical receiver is configured to receive the optical signal of the first wavelength; the optical lens combination is disposed on a reflection optical path of the first demultiplexer , the optical lens combination is configured to guide, to the second optical receiver , the optical signal of the second wavelength that is reflected by the first demultiplexer , and the second optical receiver is configured to receive the optical signal of the second wavelength.
A surgical cutting tool for use with a handpiece having a motor, the surgical cutting tool comprising: an outer tube extending longitudinally between proximal and distal ends and comprising an inner surface defining a lumen therethrough; a flexible driveshaft comprising an inner tube rotatably disposed in said lumen and extending in a longitudinal direction (X) past said distal end to a cutting end outside of said lumen , said driveshaft further comprising: at least two torsion sections spaced from one another longitudinally along said inner tube and each a having at least one channel extending through said inner tube ; and a bearing section disposed longitudinally between said torsion sections , wherein said channels are configured to collapse under rotational load in response to transmission of torque as said driveshaft rotates such that said torsion sections are spaced apart from said inner surface of said outer tube to a greater extent than said bearing section for reducing friction between said inner tube and said outer tube . an outer tube extending longitudinally between proximal and distal ends and comprising an inner surface defining a lumen therethrough; a flexible driveshaft comprising an inner tube rotatably disposed in said lumen and extending in a longitudinal direction (X) past said distal end to a cutting end outside of said lumen , said driveshaft further comprising: at least two torsion sections spaced from one another longitudinally along said inner tube and each a having at least one channel extending through said inner tube ; and a bearing section disposed longitudinally between said torsion sections , wherein said channels are configured to collapse under rotational load in response to transmission of torque as said driveshaft rotates such that said torsion sections are spaced apart from said inner surface of said outer tube to a greater extent than said bearing section for reducing friction between said inner tube and said outer tube . at least two torsion sections spaced from one another longitudinally along said inner tube and each a having at least one channel extending through said inner tube ; and a bearing section disposed longitudinally between said torsion sections , wherein said channels are configured to collapse under rotational load in response to transmission of torque as said driveshaft rotates such that said torsion sections are spaced apart from said inner surface of said outer tube to a greater extent than said bearing section for reducing friction between said inner tube and said outer tube .
A method for introducing genetic modifications at different loci of a primary T-cell, comprising the sequential steps of: a) Subjecting said primary T-cell to a first electroporation step to introduce at least a first sequence-specific reagent into said T-cell ; b) Cultivating said primary T-cell thereby enabling said first sequence-specific reagent to modify its genome at a first locus, said first locus encoding a receptor protein or cell surface antigen, c) Subjecting said modified primary T-cell to at least a second electroporation step, to introduce at least a second sequence-specific reagent into said cell, d) Cultivating and expanding said primary T-cell thereby enabling said second sequence-specific reagent to permanently reduce or prevent the expression of the protein encoded at said second locus, said second locus encoding a protein selected from PD1, CTLA4, PPP2CA, PPP2CB, PTPN6, PTPN22, LAG3, HAVCR2, BTLA, CD160, TIGIT, CD96, CRTAM, LAIR1, SIGLEC7, SIGLEC9, CD244, TNFRSF10B, TNFRSF10A, CASP8, CASP10, CASP3, CASP6, CASP7, FADD, FAS, TGFBRII, TGFRBRI, SMAD2, SMAD3, SMAD4, SMAD10, SKI, SKIL, TGIF1, IL10RA, IL10RB, HMOX2, IL6R, IL6ST, EIF2AK4, CSK, PAG1, SIT1, FOXP3, PRDM1, BATF, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, dCK, GR, GGH and HPRT, wherein the primary T-cell is cultivated in step b) from 48 hours to 72 hours. a) Subjecting said primary T-cell to a first electroporation step to introduce at least a first sequence-specific reagent into said T-cell ; b) Cultivating said primary T-cell thereby enabling said first sequence-specific reagent to modify its genome at a first locus, said first locus encoding a receptor protein or cell surface antigen, c) Subjecting said modified primary T-cell to at least a second electroporation step, to introduce at least a second sequence-specific reagent into said cell, d) Cultivating and expanding said primary T-cell thereby enabling said second sequence-specific reagent to permanently reduce or prevent the expression of the protein encoded at said second locus, said second locus encoding a protein selected from PD1, CTLA4, PPP2CA, PPP2CB, PTPN6, PTPN22, LAG3, HAVCR2, BTLA, CD160, TIGIT, CD96, CRTAM, LAIR1, SIGLEC7, SIGLEC9, CD244, TNFRSF10B, TNFRSF10A, CASP8, CASP10, CASP3, CASP6, CASP7, FADD, FAS, TGFBRII, TGFRBRI, SMAD2, SMAD3, SMAD4, SMAD10, SKI, SKIL, TGIF1, IL10RA, IL10RB, HMOX2, IL6R, IL6ST, EIF2AK4, CSK, PAG1, SIT1, FOXP3, PRDM1, BATF, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, dCK, GR, GGH and HPRT,
Method for monitoring a status of a passenger transport system , characterized in that the status of the passenger transport system is monitored using an updated digital double data record which reproduces characterizing properties of components of the passenger transport system in an actual configuration of the passenger transport system after the assembly and installation thereof in a building in a machine-processable manner, changes and change trends in the characterizing properties of components being tracked and assessed by means of the monitoring, and the method also comprising prior creation of the updated digital double data record; which creation includes at least the steps of: • creating a commissioning digital double data record with target data which reproduce the characterizing properties of components of the passenger transport system in a target configuration; • creating a completion digital double data record based on the commissioning digital double data record by measuring actual data which reproduce characterizing properties of components of the passenger transport system in the actual configuration of the passenger transport system directly after the assembly and installation thereof in a building and replacement of target data in the commissioning digital double data record with corresponding actual data; and • creating the updated digital double data record based on the completion digital double data record by modifying the completion digital double data record during operation of the passenger transport system , taking into account measurement values which reproduce changes in the characterizing properties of components of the passenger transport system during operation. • creating a commissioning digital double data record with target data which reproduce the characterizing properties of components of the passenger transport system in a target configuration; • creating a completion digital double data record based on the commissioning digital double data record by measuring actual data which reproduce characterizing properties of components of the passenger transport system in the actual configuration of the passenger transport system directly after the assembly and installation thereof in a building and replacement of target data in the commissioning digital double data record with corresponding actual data; and • creating the updated digital double data record based on the completion digital double data record by modifying the completion digital double data record during operation of the passenger transport system , taking into account measurement values which reproduce changes in the characterizing properties of components of the passenger transport system during operation.
A free-piston gas generator power plant, comprising: a free-piston engine ; a power turbine ; the free-piston engine configured to supply an exhaust gas to the power turbine via an exhaust channel; the power plant being further provided with a water supply , a heat exchanger and an injector; wherein the heat exchanger is coupled to an exhaust line from the power turbine, the exhaust line being arranged to heat the water supply to create steam, the injector arranged to inject the steam into the exhaust channel. a free-piston engine ; a power turbine ; the free-piston engine configured to supply an exhaust gas to the power turbine via an exhaust channel; the power plant being further provided with a water supply , a heat exchanger and an injector; wherein the heat exchanger is coupled to an exhaust line from the power turbine, the exhaust line being arranged to heat the water supply to create steam, the injector arranged to inject the steam into the exhaust channel.
Circuit breaker for a gas insulated switchgear (GIS) in the medium and high voltage range, comprising a housing , at least four flanges for mounting switchgear devices, a first interrupting chamber with a first electrical connection point configured to connect the first interrupting chamber to a first of said switchgear devices, a second interrupting chamber with a second electrical connection point configured to connect the second interrupting chamber to a second of said switchgear devices, characterized in that it comprises a common point conductor connecting the first interrupting chamber simultaneously to said first electrical connection point and to a third electrical connection point , said third electrical connection point being configured to connect via said common point conductor the first interrupting chamber to a third of said switchgear devices, and in that it comprises a fourth connection point configured to connect the first interrupting chamber or the second interrupting chamber to a fourth of said switchgear devices.
A semiconductor element comprising: a layer comprising a semiconductor film, wherein the semiconductor film consists of 20% to 99.5% by mass of inorganic semiconductor particles; and 0.5% to 80% by mass of an organic compound having a relative permittivity of 10 or more, wherein the mass content of organic compound is defined as the total content of organic compound and compounds produced by oxidation of the organic compound. 20% to 99.5% by mass of inorganic semiconductor particles; and 0.5% to 80% by mass of an organic compound having a relative permittivity of 10 or more, wherein the mass content of organic compound is defined as the total content of organic compound and compounds produced by oxidation of the organic compound.
An aqueous composition for pre-treating a substrate prior to inkjet printing thereon, the composition comprising: (a) one or more water-soluble salts of a multivalent metal cation; and (b) composite particles having a Rockwell Hardness of less than or equal to R90 and each of the composite particles comprising domains of a (i) first organic polymer and domains of a (ii) second organic polymer, wherein: the domains of the (ii) second organic polymer are dispersed within the domains of the (i) first organic polymer; the melting point of the (i) first organic polymer is lower than the melting point of the (ii) second organic polymer; and the weight ratio of the (i) first organic polymer to the (ii) second organic polymer is chosen such that the (b) composite particles have a density of at least 1.0 g/ml and up to and including 1.5 g/ml. (a) one or more water-soluble salts of a multivalent metal cation; and (b) composite particles having a Rockwell Hardness of less than or equal to R90 and each of the composite particles comprising domains of a (i) first organic polymer and domains of a (ii) second organic polymer, wherein: the domains of the (ii) second organic polymer are dispersed within the domains of the (i) first organic polymer; the melting point of the (i) first organic polymer is lower than the melting point of the (ii) second organic polymer; and the weight ratio of the (i) first organic polymer to the (ii) second organic polymer is chosen such that the (b) composite particles have a density of at least 1.0 g/ml and up to and including 1.5 g/ml. the domains of the (ii) second organic polymer are dispersed within the domains of the (i) first organic polymer; the melting point of the (i) first organic polymer is lower than the melting point of the (ii) second organic polymer; and the weight ratio of the (i) first organic polymer to the (ii) second organic polymer is chosen such that the (b) composite particles have a density of at least 1.0 g/ml and up to and including 1.5 g/ml.
A measurement reporting method, comprising: receiving, by a terminal device, pilot measurement configuration information of a plurality of carriers from a network device; performing, by the terminal device, measurement based on the pilot measurement configuration information of the plurality of carriers, to obtain measurement report results of the plurality of carriers; and sending, by the terminal device, the measurement report results of the plurality of carriers to a network device; characterized in that the pilot measurement configuration information of the plurality of carriers indicates a pilot association relationship of the plurality of carriers, and the pilot association relationship of the plurality of carriers indicates that pilots of the plurality of carriers correspond to a same spatial domain transmit filter. receiving, by a terminal device, pilot measurement configuration information of a plurality of carriers from a network device; performing, by the terminal device, measurement based on the pilot measurement configuration information of the plurality of carriers, to obtain measurement report results of the plurality of carriers; and sending, by the terminal device, the measurement report results of the plurality of carriers to a network device; characterized in that the pilot measurement configuration information of the plurality of carriers indicates a pilot association relationship of the plurality of carriers, and the pilot association relationship of the plurality of carriers indicates that pilots of the plurality of carriers correspond to a same spatial domain transmit filter.