mhurhangee/patent-ind-claim-en huggingface dataset:
A saddle-riding type motorcycle comprising at least two front wheels and at least one drive wheel rolling, wherein said motor vehicle further comprises: - a frame (2A-2B); - a motor assembly supported by a rear part of said frame (2A-2B); - an articulated rolling quadrilateral connected to a front part of said frame (2A-2B), wherein said articulated rolling quadrilateral supports a first front wheel and a second front wheel respectively, so as to allow said first front wheel and said second front wheel a rolling movement; - a steering assembly configured to steer said front wheels , - a suspension assembly interposed between said front wheels and said articulated rolling quadrilateral to allow a sussultatory movement of said front wheels with respect to said articulated rolling quadrilateral ; wherein said articulated rolling quadrilateral comprises a lower cross member and an upper cross member hinged to said front part of said frame (2A-2B) so as to oscillate about median rolling axes that are parallel and substantially lying on a center plane (A-A) of said motor vehicle , said articulated rolling quadrilateral further comprising a first upright and a second upright hinged to said cross members so as to rotate about further rolling axes parallel to said median rolling axes , wherein it comprises a front fairing directly and rigidly connected to one of said cross-members of said articulated rolling quadrilateral and wherein said front fairing comprises two wheel arch portions arranged above said front wheels . - a frame (2A-2B); - a motor assembly supported by a rear part of said frame (2A-2B); - an articulated rolling quadrilateral connected to a front part of said frame (2A-2B), wherein said articulated rolling quadrilateral supports a first front wheel and a second front wheel respectively, so as to allow said first front wheel and said second front wheel a rolling movement; - a steering assembly configured to steer said front wheels , - a suspension assembly interposed between said front wheels and said articulated rolling quadrilateral to allow a sussultatory movement of said front wheels with respect to said articulated rolling quadrilateral ; wherein said articulated rolling quadrilateral comprises a lower cross member and an upper cross member hinged to said front part of said frame (2A-2B) so as to oscillate about median rolling axes that are parallel and substantially lying on a center plane (A-A) of said motor vehicle , said articulated rolling quadrilateral further comprising a first upright and a second upright hinged to said cross members so as to rotate about further rolling axes parallel to said median rolling axes , wherein it comprises a front fairing directly and rigidly connected to one of said cross-members of said articulated rolling quadrilateral and wherein said front fairing comprises two wheel arch portions arranged above said front wheels .
A system comprising: a first electrode and a second electrode , the first and second electrodes configurable to electrically engage tissue of a patient; a processor in communication with the first and second electrodes, the processor configured to: receive electrical signals representative of a patient's physiological activity; and characterized in that the processor is further configured to: determine a relative impedance difference between the first and the second electrodes ; compare the relative impedance difference to a threshold value ; when the relative impedance difference exceeds the given threshold, cause a sub-therapeutic stimulation pulse to be applied to one of the first and second electrodes such as to reduce the relative impedance difference ; and receive subsequent electrical signals with the first electrode and the second electrode having the reduced relative impedance difference there between. a first electrode and a second electrode , the first and second electrodes configurable to electrically engage tissue of a patient; a processor in communication with the first and second electrodes, the processor configured to: receive electrical signals representative of a patient's physiological activity; and characterized in that the processor is further configured to: determine a relative impedance difference between the first and the second electrodes ; compare the relative impedance difference to a threshold value ; when the relative impedance difference exceeds the given threshold, cause a sub-therapeutic stimulation pulse to be applied to one of the first and second electrodes such as to reduce the relative impedance difference ; and receive subsequent electrical signals with the first electrode and the second electrode having the reduced relative impedance difference there between. receive electrical signals representative of a patient's physiological activity; and characterized in that the processor is further configured to: determine a relative impedance difference between the first and the second electrodes ; compare the relative impedance difference to a threshold value ; when the relative impedance difference exceeds the given threshold, cause a sub-therapeutic stimulation pulse to be applied to one of the first and second electrodes such as to reduce the relative impedance difference ; and receive subsequent electrical signals with the first electrode and the second electrode having the reduced relative impedance difference there between. determine a relative impedance difference between the first and the second electrodes ; compare the relative impedance difference to a threshold value ; when the relative impedance difference exceeds the given threshold, cause a sub-therapeutic stimulation pulse to be applied to one of the first and second electrodes such as to reduce the relative impedance difference ; and receive subsequent electrical signals with the first electrode and the second electrode having the reduced relative impedance difference there between.
A pharmaceutical solution for use in enhancing anti-tumor efficacy and in reducing toxicity of an anti-tumor drug, when used in combination with at least one anti-tumor drug in the treatment or prevention of malignant tumors, wherein the pharmaceutical solution contains deuterium oxide as a solvent, wherein every 100 ml of the pharmaceutical solution contain 95 to 99.9 ml deuterium oxide, and in the deuterium oxide the isotope abundance of deuterium is 90% to 99.9%, and wherein the anti-tumor drug is selected from the group consisting of 5-fluorouracil, gemcitabine, mitomycin, oxaliplatin, paclitaxel, thiotepa and bevacizumab.
A detecting method for blood, comprising: providing a sensing device , wherein the sensing device comprises a base and at least one response electrode , and the response electrode is spaced apart from the base relative to a gate end of the base ; placing a blood on the response electrode , wherein the blood includes a plurality of blood cells and a plurality of targets; separating the blood into a first part and a second part, wherein the first part is in contact with the response electrode , and a blood cell count of the first part is less than a blood cell count of the second part; and applying a voltage to the response electrode such that an electric field is generated between the response electrode and the gate end of the base and measuring a detection current generated from the base to measure a property of the target, the detecting method being characterized in that the step of separating the blood into the first part and the second part comprises inverting the sensing device in which the blood is placed to separate the blood into the first part and the second part by gravity wherein the response electrode and the gate end of the base are located on a same plane. providing a sensing device , wherein the sensing device comprises a base and at least one response electrode , and the response electrode is spaced apart from the base relative to a gate end of the base ; placing a blood on the response electrode , wherein the blood includes a plurality of blood cells and a plurality of targets; separating the blood into a first part and a second part, wherein the first part is in contact with the response electrode , and a blood cell count of the first part is less than a blood cell count of the second part; and applying a voltage to the response electrode such that an electric field is generated between the response electrode and the gate end of the base and measuring a detection current generated from the base to measure a property of the target, the detecting method being characterized in that the step of separating the blood into the first part and the second part comprises inverting the sensing device in which the blood is placed to separate the blood into the first part and the second part by gravity wherein the response electrode and the gate end of the base are located on a same plane.
A method for decoding base sequence of a nucleic acid corresponding to an end region of RNA, comprising: a preparing-decoding step of preparing, using a template RNA, an RNA nucleic acid of a 5'-end region of the template RNA or a complementary DNA nucleic acid corresponding to the 5'-end region of the template RNA or a nucleic acid having a sequence that has two or more linked sequences thereof, and decoding sequence of the nucleic acid by cap-analysis gene expression (CAGE) method, wherein the template RNA used in the preparing-decoding step is a native nascent RNA. a preparing-decoding step of preparing, using a template RNA, an RNA nucleic acid of a 5'-end region of the template RNA or a complementary DNA nucleic acid corresponding to the 5'-end region of the template RNA or a nucleic acid having a sequence that has two or more linked sequences thereof, and decoding sequence of the nucleic acid by cap-analysis gene expression (CAGE) method, wherein the template RNA used in the preparing-decoding step is a native nascent RNA.
A clamping element configured to be pressed to a baseplate of at least one power semiconductor module comprising a mold , comprising - at least two contact areas being configured to be in direct contact to at least one clamping area of the baseplate being free of the mold , and - at least two recesses provided in the clamping element , - at least two holes , wherein - at least one recess and at least one contact area are configured to face the baseplate , - the clamping element is configured to connect the at least one power semiconductor module with a cooler . - at least two contact areas being configured to be in direct contact to at least one clamping area of the baseplate being free of the mold , and - at least two recesses provided in the clamping element , - at least two holes , wherein - at least one recess and at least one contact area are configured to face the baseplate , - the clamping element is configured to connect the at least one power semiconductor module with a cooler .
A cytotoxic compound having the structure (IV): where: R 5 is alkyl, alkenyl, alkylacyl, cycloalkyl, heterocycle, -CN, alkoxy, -N(R 6 ) 2 , -CON(R 6 ) 2 , -S(O)R 6 , -SR 6 , -SO 2 R 6 ; and R 6 is H, alkyl, or cycloalkyl. R 5 is alkyl, alkenyl, alkylacyl, cycloalkyl, heterocycle, -CN, alkoxy, -N(R 6 ) 2 , -CON(R 6 ) 2 , -S(O)R 6 , -SR 6 , -SO 2 R 6 ; and R 6 is H, alkyl, or cycloalkyl.
Clock phase recovery apparatus for estimating an estimated clock phase, the clock phase recovery apparatus comprising: a clock estimator configured to estimate a first clock signal and a second clock signal upon the basis of an input signal, the input signal comprising a first sub-signal according to a first optical polarization and a second sub-signal according to a second optical polarization, the first clock signal comprising a first clock magnitude and a first clock phase, the second clock signal comprising a second clock magnitude and a second clock phase; a selector configured to select the first clock phase to form the estimated clock phase if the first clock magnitude is greater than the second clock magnitude, or to select the second clock phase to form the estimated clock phase if the second clock magnitude is greater than the first clock magnitude, wherein the clock estimator comprises a filter bank comprising a plurality of chromatic dispersion filters, each chromatic dispersion filter being configured to filter the input signal by a different predetermined chromatic dispersion value to obtain a plurality of filtered input signals, the clock phase recovery apparatus characterized in that : the clock estimator is configured to estimate a plurality of clock signals upon the basis of the plurality of the filtered input signals, and wherein the selector is configured to select the clock phase or the clock signal which has the greatest clock magnitude among the plurality of estimated clock signals to provide the estimated clock phase. a clock estimator configured to estimate a first clock signal and a second clock signal upon the basis of an input signal, the input signal comprising a first sub-signal according to a first optical polarization and a second sub-signal according to a second optical polarization, the first clock signal comprising a first clock magnitude and a first clock phase, the second clock signal comprising a second clock magnitude and a second clock phase; a selector configured to select the first clock phase to form the estimated clock phase if the first clock magnitude is greater than the second clock magnitude, or to select the second clock phase to form the estimated clock phase if the second clock magnitude is greater than the first clock magnitude, wherein the clock estimator comprises a filter bank comprising a plurality of chromatic dispersion filters, each chromatic dispersion filter being configured to filter the input signal by a different predetermined chromatic dispersion value to obtain a plurality of filtered input signals, the clock phase recovery apparatus characterized in that : the clock estimator is configured to estimate a plurality of clock signals upon the basis of the plurality of the filtered input signals, and wherein the selector is configured to select the clock phase or the clock signal which has the greatest clock magnitude among the plurality of estimated clock signals to provide the estimated clock phase.
Hub carrier for a vehicle, comprising at least one receiving opening in which a wheel bearing , via which at least one wheel hub of the vehicle is to be rotatably mounted on the hub carrier , can be at least partially received, and comprising a centring seat arranged in the receiving opening , by means of which the wheel bearing can be supported in the radial direction on the hub carrier and centred relative to the hub carrier , the centring seat having a plurality of centring surface segments which follow one another in the circumferential direction of the receiving opening and are spaced apart from one another and between which respective recesses of the hub carrier are arranged, characterised in that the recesses are bounded in the axial direction of the receiving opening by the hub carrier .
A vehicle engine system including a turbocharger comprising: a fuel pump for selectively delivering fuel under high pressure; an accumulator having a first chamber for receiving an output from the fuel pump and a second chamber for receiving an oil feed, wherein as one of the first and second chambers is filled up the other of the first and second chambers is compressed; wherein on vehicle acceleration the fuel pump delivers fuel to a common rail fuel injection system , and on vehicle braking the fuel pump delivers fuel to the first chamber of the accumulator to thereby put the oil in the second chamber under pressure, and wherein on subsequent acceleration the oil chamber delivers an output under pressure to the turbocharger. a fuel pump for selectively delivering fuel under high pressure; an accumulator having a first chamber for receiving an output from the fuel pump and a second chamber for receiving an oil feed, wherein as one of the first and second chambers is filled up the other of the first and second chambers is compressed; wherein on vehicle acceleration the fuel pump delivers fuel to a common rail fuel injection system , and on vehicle braking the fuel pump delivers fuel to the first chamber of the accumulator to thereby put the oil in the second chamber under pressure, and wherein on subsequent acceleration the oil chamber delivers an output under pressure to the turbocharger.
Optical system for imaging an object (O), having - at least a first objective , - at least a first image stabilizing unit and - at least a first eyepiece , wherein, - as seen in the direction of the first eyepiece from the first objective , the first objective is arranged first along a first optical axis , then followed by the first image stabilizing unit and then followed by the first eyepiece , - the first image stabilizing unit is rotatably mounted in cardan-joint fashion about a first hinge point , and wherein - the first hinge point is arranged between the first objective and the first eyepiece , - the first image stabilizing unit comprises at least a first lens unit and at least a first optical element , wherein the first lens unit and the first optical element are arranged such that the first lens unit is, together with the first optical element , rotatably mounted in cardan-joint fashion about the first hinge point , and wherein the first optical element is embodied as a first prism erecting system, characterized in that the first lens unit is embodied as a first meniscus lens in order to avoid a bothersome coma and has negative refractive power. - at least a first objective , - at least a first image stabilizing unit and - at least a first eyepiece , - as seen in the direction of the first eyepiece from the first objective , the first objective is arranged first along a first optical axis , then followed by the first image stabilizing unit and then followed by the first eyepiece , - the first image stabilizing unit is rotatably mounted in cardan-joint fashion about a first hinge point , and wherein - the first hinge point is arranged between the first objective and the first eyepiece , - the first image stabilizing unit comprises at least a first lens unit and at least a first optical element , wherein the first lens unit and the first optical element are arranged such that the first lens unit is, together with the first optical element , rotatably mounted in cardan-joint fashion about the first hinge point , and wherein the first optical element is embodied as a first prism erecting system,
A protease variant comprising the alteration Q198E, wherein positions correspond to the positions of SEQ ID NO: 3, wherein the protease variant has a sequence identity to SEQ ID NO: 3 of at least 90%, and the variant has protease activity, and wherein the variant comprises a set of alterations selected from the group consisting of: S27K,Q70A,I121V,E127Q,S173P,G174K,S175P,F180Y,G182A,L184F,Q197K,Q198E, T297P; S27K,*108aA,N109S,V162T,S173P,G174K,S175A,F180Y,G182A,L184F,Q197K, Q198E,T297P; S27K,I121V,S173P,G174R,S175A,F180Y,G182A,L184Y,Q197K,Q198E,S270V,T297P; S27K,N59L,T67V,I121V,S173P,G174K,S175P,F180Y,G182A,L184Y,Q197K,Q198E, T297P; S27K,N109R,S111E,V162T,S173P,G174K,S175A,F180Y,G182A,L184F,Q197K,Q198E, T297P; S27K,N87K,S171D,S173P,G174R,S175P,G182A,L184F,Q198E,N199R,T297P; S27K,Q70A,S171D,S173P,G174R,S175P,F180Y,G182A,L184F,Q198E,N199K,S274V, T297P; S27K,*108aA,N109S,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q198E, N199K,T297P; S27K,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K,T297P; S27K,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,V286R,T297P; S27K,N109R,S111E,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K, T297P; S27K,Q70N,I121V,S173P,G174K,S175P,G182A,L184F,Q198E,T297P; S27K,N109K,S111E,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K, T297P; S27K,V162T,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q197K,Q198E,T297P; and S27K,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q198E,N199K,T297P. S27K,Q70A,I121V,E127Q,S173P,G174K,S175P,F180Y,G182A,L184F,Q197K,Q198E, T297P; S27K,*108aA,N109S,V162T,S173P,G174K,S175A,F180Y,G182A,L184F,Q197K, Q198E,T297P; S27K,I121V,S173P,G174R,S175A,F180Y,G182A,L184Y,Q197K,Q198E,S270V,T297P; S27K,N59L,T67V,I121V,S173P,G174K,S175P,F180Y,G182A,L184Y,Q197K,Q198E, T297P; S27K,N109R,S111E,V162T,S173P,G174K,S175A,F180Y,G182A,L184F,Q197K,Q198E, T297P; S27K,N87K,S171D,S173P,G174R,S175P,G182A,L184F,Q198E,N199R,T297P; S27K,Q70A,S171D,S173P,G174R,S175P,F180Y,G182A,L184F,Q198E,N199K,S274V, T297P; S27K,*108aA,N109S,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q198E, N199K,T297P; S27K,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K,T297P; S27K,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,V286R,T297P; S27K,N109R,S111E,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K, T297P; S27K,Q70N,I121V,S173P,G174K,S175P,G182A,L184F,Q198E,T297P; S27K,N109K,S111E,S171E,S173P,G174K,S175P,F180Y,G182A,L184F,Q198E,N199K, T297P; S27K,V162T,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q197K,Q198E,T297P; and S27K,S171D,S173P,G174R,S175A,F180Y,G182A,L184F,Q198E,N199K,T297P.
An in vitro method for altering of the functional state of any nucleic acid enabling its selective and specific recognition, and subsequently selective intervention, manipulation, detection, quantification, labeling, pre-targeting and sorting thereof, characterized in that , the method comprises targeting said nucleic acid with a construct to form a stable heteroduplex, and wherein the construct comprises at least two sequence-specific single-stranded oligonucleotides being mutually interconnected through a size-specific linking moiety, each of the sequence-specific single-stranded oligonucleotides is targeted to a pre-defined target sequence of the nucleic acid resulting in the formation of a stable heteroduplex, each of the oligonucleotides within the one construct recognizes different complementary sequences of the target nucleic acid, the length of the size-specific linking moiety is adjusted to the mutual distance between the target sequences of the target nucleic acid and is between 5 and 1000 angstrom. the method comprises targeting said nucleic acid with a construct to form a stable heteroduplex, and wherein the construct comprises at least two sequence-specific single-stranded oligonucleotides being mutually interconnected through a size-specific linking moiety, each of the sequence-specific single-stranded oligonucleotides is targeted to a pre-defined target sequence of the nucleic acid resulting in the formation of a stable heteroduplex, each of the oligonucleotides within the one construct recognizes different complementary sequences of the target nucleic acid, the length of the size-specific linking moiety is adjusted to the mutual distance between the target sequences of the target nucleic acid and is between 5 and 1000 angstrom.