Apparatus for analysis of a target comprising: a first device arranged and adapted to generate aerosol, smoke or vapour from one or more regions of the target; a tool comprising said first device located within a tubing or a housing , wherein said tubing or said housing comprises a tool deployment opening and one or more separate aspiration ports ; a second device arranged and adapted to aspirate aerosol, smoke or vapour generated using said first device through said one or more aspiration ports ; a mass spectrometer and/or ion mobility spectrometer with a vacuum chamber and a collision surface located within said vacuum chamber; the apparatus further comprising: tubing which is arranged and adapted to pass said aerosol, smoke or vapour into said vacuum chamber of said mass spectrometer and/or ion mobility spectrometer; and a third device arranged and adapted to add a matrix to said aerosol, smoke or vapour, wherein said matrix is selected from the group consisting of: (i) a solvent for said aerosol, smoke or vapour; (ii) an organic solvent; (iii) a volatile compound; (iv) polar molecules; (v) water; (vi) one or more alcohols; (vii) methanol; (viii) ethanol; (ix) isopropanol; (x) acetone; and (xi) acetonitrile, and wherein said matrix is added, in use, to said aerosol, smoke or vapour prior to said aerosol, smoke or vapour impacting upon said collision surface. a first device arranged and adapted to generate aerosol, smoke or vapour from one or more regions of the target; a tool comprising said first device located within a tubing or a housing , wherein said tubing or said housing comprises a tool deployment opening and one or more separate aspiration ports ; a second device arranged and adapted to aspirate aerosol, smoke or vapour generated using said first device through said one or more aspiration ports ; a mass spectrometer and/or ion mobility spectrometer with a vacuum chamber and a collision surface located within said vacuum chamber; the apparatus further comprising: tubing which is arranged and adapted to pass said aerosol, smoke or vapour into said vacuum chamber of said mass spectrometer and/or ion mobility spectrometer; and a third device arranged and adapted to add a matrix to said aerosol, smoke or vapour, wherein said matrix is selected from the group consisting of: (i) a solvent for said aerosol, smoke or vapour; (ii) an organic solvent; (iii) a volatile compound; (iv) polar molecules; (v) water; (vi) one or more alcohols; (vii) methanol; (viii) ethanol; (ix) isopropanol; (x) acetone; and (xi) acetonitrile, and wherein said matrix is added, in use, to said aerosol, smoke or vapour prior to said aerosol, smoke or vapour impacting upon said collision surface. tubing which is arranged and adapted to pass said aerosol, smoke or vapour into said vacuum chamber of said mass spectrometer and/or ion mobility spectrometer; and a third device arranged and adapted to add a matrix to said aerosol, smoke or vapour, wherein said matrix is selected from the group consisting of: (i) a solvent for said aerosol, smoke or vapour; (ii) an organic solvent; (iii) a volatile compound; (iv) polar molecules; (v) water; (vi) one or more alcohols; (vii) methanol; (viii) ethanol; (ix) isopropanol; (x) acetone; and (xi) acetonitrile, and wherein said matrix is added, in use, to said aerosol, smoke or vapour prior to said aerosol, smoke or vapour impacting upon said collision surface. <EOS>