A method for producing an epigenetic monocytogram, comprising the steps of: a) performing qPCR assays and determining and providing qPCR assay-specific correction factors, in order to normalize the assays, and to correct for differences in assay efficiencies, b) providing and detecting blood cells in a biological sample comprising DNA methylation analysis comprising bisulfite conversion of at least one marker-region that is specific for each of the blood cells of a monocytogram to be detected, wherein said cells of said monocytogram are selected from CD14 + monocytes, CD14 - monocytes, macrophages, plasmacytoid dendritic cells, monocytic myeloid-derived suppressor cells, intermediate monocytes, classical monocytes, non-classical monocytes, and/or overall dendritic cells, and combinations thereof; and c) quantifying said blood cells of the monocytogram to be detected, comprising assessment of the relative amount of bisulfite converted DNA per cell via qPCR and comprising normalization of said amount using a normalization standard, wherein said normalization standard is a nucleic acid molecule comprising at least one marker-region being specific for each of the blood cells of the monocytogram to be detected, and at least one control-region being cell-unspecific, wherein said regions are present in the same number of copies on said molecule and in a cell of a blood cell sample of known cellular composition, wherein the marker-regions being specific for each of the blood cells of the monocytogram to be detected are selected from the group of regions according to SEQ ID No 427 to 496 and a discovery fragment according to table 4F, wherein a bisulfite conversion of at least one CpG position in said marker region is indicative for at least one cell type of the monocytogram. a) performing qPCR assays and determining and providing qPCR assay-specific correction factors, in order to normalize the assays, and to correct for differences in assay efficiencies, b) providing and detecting blood cells in a biological sample comprising DNA methylation analysis comprising bisulfite conversion of at least one marker-region that is specific for each of the blood cells of a monocytogram to be detected, wherein said cells of said monocytogram are selected from CD14 + monocytes, CD14 - monocytes, macrophages, plasmacytoid dendritic cells, monocytic myeloid-derived suppressor cells, intermediate monocytes, classical monocytes, non-classical monocytes, and/or overall dendritic cells, and combinations thereof; and c) quantifying said blood cells of the monocytogram to be detected, comprising assessment of the relative amount of bisulfite converted DNA per cell via qPCR and comprising normalization of said amount using a normalization standard, wherein said normalization standard is a nucleic acid molecule comprising at least one marker-region being specific for each of the blood cells of the monocytogram to be detected, and at least one control-region being cell-unspecific, wherein said regions are present in the same number of copies on said molecule and in a cell of a blood cell sample of known cellular composition, wherein the marker-regions being specific for each of the blood cells of the monocytogram to be detected are selected from the group of regions according to SEQ ID No 427 to 496 and a discovery fragment according to table 4F, wherein a bisulfite conversion of at least one CpG position in said marker region is indicative for at least one cell type of the monocytogram. <EOS>