A machine to manufacture components made of wood or the like starting from a flat panel delimited by a first side face , which is parallel to a first direction , and by a pair of second side faces (4, 4*), which are opposite one another and parallel to a second direction perpendicular to the first direction , the machine comprising support means defining a support surface (P) for the panel ; a first holding device , which is designed to hold the panel in the area of a second side face ; and at least one operating head (33; 38) to process the panel ; wherein the first holding device and the operating head (33; 38) are movable relative to one another at least in the first direction , so as to allow the operating head (33; 38) to separate at least one component from the panel ; wherein a second holding device , is designed to hold the panel in the area of the other second side face (4, 4*), characterized in that each one of said first and second holding devices comprises at least one clamping member provided with two jaws , which are movable between a clamping position and a release position to clamp and release the panel , wherein the first holding device and the second holding device comprise at least one clamping member comprising, in turn, a lower jaw and an upper jaw , which are movable between a clamping position and a release position to clamp and release the panel ; wherein the support means having a plurality of feeding channels , which extend in the first direction , open up towards the outside in the area of the support surface (P) and are engaged by the lower jaws of the respective clamping members in a sliding manner, wherein said machine is such that the support means further have a cutting channel , which extends in the second direction and through said further feeding channels , and is engaged by a tool (35; 40) of at least one operating head (33; 38). wherein the first holding device and the operating head (33; 38) are movable relative to one another at least in the first direction , so as to allow the operating head (33; 38) to separate at least one component from the panel ; wherein a second holding device , is designed to hold the panel in the area of the other second side face (4, 4*), characterized in that each one of said first and second holding devices comprises at least one clamping member provided with two jaws , which are movable between a clamping position and a release position to clamp and release the panel , wherein the first holding device and the second holding device comprise at least one clamping member comprising, in turn, a lower jaw and an upper jaw , which are movable between a clamping position and a release position to clamp and release the panel ; wherein the support means having a plurality of feeding channels , which extend in the first direction , open up towards the outside in the area of the support surface (P) and are engaged by the lower jaws of the respective clamping members in a sliding manner, wherein said machine is such that the support means further have a cutting channel , which extends in the second direction and through said further feeding channels , and is engaged by a tool (35; 40) of at least one operating head (33; 38). <EOS>