mhurhangee/patent-ind-claim-en huggingface dataset:
Flow rate regulator having a deformable, preferably annular, regulating body which is inserted into a corresponding groove , wherein a regulating profile is formed on at least one groove side wall , wherein the regulating profile is formed from a series of regulating protrusions and regulating clearances, and the regulating body and the regulating profile delimit between them a regulating gap such that a change in shape of the regulating body gives rise to a change in size of the regulating gap , wherein adjacent regulating protrusions are arranged at a spacing from one another, and therefore a series of spacings is formed, along the circumference, between respectively adjacent regulating protrusions , wherein at least two spacings in the series of spacings are selected to be of different sizes from one another, characterized - in that one spacing of the at least two spacings is more than three times as large as another spacing of the at least two spacings . - in that one spacing of the at least two spacings is more than three times as large as another spacing of the at least two spacings .
A composition comprising synthetic nanocarriers comprising poly(D,L lactide) (PLA) and poly(D,L lactide) poly(ethylene glycol) (PLA-PEG) and comprising rapamycin, and a composition comprising pegsiticase for use in a method of treating a subject with gout or a condition associated with gout, hyperuricemia, or an elevated serum uric acid level and/or undesired uric acid deposits, wherein the method comprises administering the compositions concomitantly to a subject and wherein the composition comprising pegsiticase is administered at a dose of 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, or 1.2 mg/kg pegsiticase with each administration, and wherein the composition comprising synthetic nanocarriers and the composition comprising pegsiticase are administered monthly for at least three months.
A system-in-package comprising: a first active die having a first plurality of electrical connectors on a top surface of said first active die ; an interposer situated over said first active die ; a second active die having a second plurality of electrical connectors on a bottom surface of said second active die ; said interposer being configured to selectively couple at least one of said first plurality of electrical connectors to at least one of said second plurality of electrical connectors ; and a socket enclosing said first and second active dies and said interposer , said socket being electrically coupled to at least one of said first active die , said second active die , and said interposer , such that said socket provides thermal dissipation for said first active die , said second active die , and said interposer ; wherein said socket is formed of a non-metal material and comprises electrical routing formed therein for providing electrical connections through socket contacts either to each of said first and second active dies or to said interposer . a first active die having a first plurality of electrical connectors on a top surface of said first active die ; an interposer situated over said first active die ; a second active die having a second plurality of electrical connectors on a bottom surface of said second active die ; said interposer being configured to selectively couple at least one of said first plurality of electrical connectors to at least one of said second plurality of electrical connectors ; and a socket enclosing said first and second active dies and said interposer , said socket being electrically coupled to at least one of said first active die , said second active die , and said interposer , such that said socket provides thermal dissipation for said first active die , said second active die , and said interposer ; wherein said socket is formed of a non-metal material and comprises electrical routing formed therein for providing electrical connections through socket contacts either to each of said first and second active dies or to said interposer .
A photoresistless method of forming a patterned hard mask on a surface of a substrate comprising the steps of: providing a reduced pressure chamber; forming a gas cluster ion beam comprising gas cluster ions comprising carbon atoms within the reduced pressure chamber; accelerating the gas cluster ions to form an accelerated gas cluster ion beam along a beam path within the reduced pressure chamber; promoting fragmentation and/or dissociation of at least a portion of the accelerated gas cluster ions along the beam path; removing charged particles from the beam path to form an accelerated neutral beam along the beam path in the reduced pressure chamber; introducing a patterned template and the substrate into the reduced pressure chamber; holding the substrate in the beam path; treating a portion of a surface of the substrate by irradiating it through openings in the patterned template with the accelerated neutral beam to form a hardened and/or densified carbon-containing patterned layer on the irradiated portion of the surface by implanting carbon atoms into the irradiated portion of the surface; separating the template from the substrate; first etching the surface having the carbon-containing patterned layer to preferentially remove material in non-carbon-containing parts of the surface, forming one or more trench(es) and one or more plateau(s); forming a hard mask layer over the plateau(s) and trench(es); planarizing the hard mask layer to remove it from the plateau(s), but not the trench(es); and optionally, second etching the surface, using the hard mask layer as a mask to remove substrate material. providing a reduced pressure chamber; forming a gas cluster ion beam comprising gas cluster ions comprising carbon atoms within the reduced pressure chamber; accelerating the gas cluster ions to form an accelerated gas cluster ion beam along a beam path within the reduced pressure chamber; promoting fragmentation and/or dissociation of at least a portion of the accelerated gas cluster ions along the beam path; removing charged particles from the beam path to form an accelerated neutral beam along the beam path in the reduced pressure chamber; introducing a patterned template and the substrate into the reduced pressure chamber; holding the substrate in the beam path; treating a portion of a surface of the substrate by irradiating it through openings in the patterned template with the accelerated neutral beam to form a hardened and/or densified carbon-containing patterned layer on the irradiated portion of the surface by implanting carbon atoms into the irradiated portion of the surface; separating the template from the substrate; first etching the surface having the carbon-containing patterned layer to preferentially remove material in non-carbon-containing parts of the surface, forming one or more trench(es) and one or more plateau(s); forming a hard mask layer over the plateau(s) and trench(es); planarizing the hard mask layer to remove it from the plateau(s), but not the trench(es); and optionally, second etching the surface, using the hard mask layer as a mask to remove substrate material.
A multi-branched drug conjugate or the pharmaceutically acceptable salt thereof: wherein R is an organic core, POLY is a polymer, L is a multivalent linker represented by the following formula: wherein the symbol "*" represents an attachment point of the multivalent linker L to the targeting molecule T, "#" represents an attachment point of the multivalent linker L to the active agent D, and "%" represents an attachment point of the multivalent linker L to the POLY, wherein m is any integer between 1-20, and / and n are independently any integer between 1-10, and preferably, / is 5, m is 3 and n is 4, T is a targeting molecule, D is an active agent and q is any integer between 3-8, wherein D is a camptothecin-based drug represented by the following formula: wherein R 1 -R 5 are selected from the following groups independently from each other: hydrogen, halogen, acyl, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, alkynyl, cycloalkyl, hydroxy, cyano, nitro, azido, amido, hydrazine, amine, substituted amine, hydroxycarbonyl, alkoxycarbonyl, alkoxycarbonyloxy, carbamoyloxy, arylsulfonyloxy and alkylsulfonyloxy; R 6 is H or OR 8 ; R 8 is alkyl, alkenyl, cycloalkyl, haloalkyl or hydroxyalkyl; R 7 is hydroxy; and T is a CD44-targeted polypeptide. R is an organic core, POLY is a polymer, L is a multivalent linker represented by the following formula: wherein the symbol "*" represents an attachment point of the multivalent linker L to the targeting molecule T, "#" represents an attachment point of the multivalent linker L to the active agent D, and "%" represents an attachment point of the multivalent linker L to the POLY, wherein m is any integer between 1-20, and / and n are independently any integer between 1-10, and preferably, / is 5, m is 3 and n is 4, T is a targeting molecule, D is an active agent and q is any integer between 3-8, wherein D is a camptothecin-based drug represented by the following formula: wherein R 1 -R 5 are selected from the following groups independently from each other: hydrogen, halogen, acyl, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, alkynyl, cycloalkyl, hydroxy, cyano, nitro, azido, amido, hydrazine, amine, substituted amine, hydroxycarbonyl, alkoxycarbonyl, alkoxycarbonyloxy, carbamoyloxy, arylsulfonyloxy and alkylsulfonyloxy; R 6 is H or OR 8 ; R 8 is alkyl, alkenyl, cycloalkyl, haloalkyl or hydroxyalkyl; R 7 is hydroxy; and T is a CD44-targeted polypeptide.
A method comprising: accessing , by a transmitter physical layer, PHY, controller, data for transmission to a receiver PHY controller over a network connection; randomizing a delimiter independently of randomizing the data; selecting a disparity reset value based on the randomized delimiter to generate an initial running disparity; encoding the randomized data based on the initial running disparity; generating a frame that includes the encoded randomized data and the randomized delimiter; and transmitting the frame from the transmitter PHY controller to the receiver PHY controller. accessing , by a transmitter physical layer, PHY, controller, data for transmission to a receiver PHY controller over a network connection; randomizing a delimiter independently of randomizing the data; selecting a disparity reset value based on the randomized delimiter to generate an initial running disparity; encoding the randomized data based on the initial running disparity; generating a frame that includes the encoded randomized data and the randomized delimiter; and transmitting the frame from the transmitter PHY controller to the receiver PHY controller.
A roll holder for a label roll, in particular for a label printer for a packaging machine for wrapping products (P) with a packaging film (K), having a horizontally arranged, fixed-position holding mandrel whose one end is fastened to a carrier and whose other end projects in an unsupported manner from the carrier ; and having a first roll mount and a second roll mount separate from the first roll mount , with the first roll mount being configured to engage into a first end of the label roll, and with the second roll mount being configured to engage into a second end of the label roll such that the label roll is receivable between the two roll mounts , wherein the second roll mount can be pushed onto the holding mandrel from the unsupported end of the holding mandrel , and wherein the first roll mount comprises a first mount section to engage into the first end of the label roll and the second roll mount comprises a second mount section to engage into the second end of the label roll, characterized in that the two mount sections each comprise a plurality of prolongations arranged distributed in the peripheral direction, with the prolongations of the two mount sections being able to engage into one another in a finger-like manner on at least one discrete rotational position of the two mount sections toward one another so that the two mount sections can be pushed into one another. having a horizontally arranged, fixed-position holding mandrel whose one end is fastened to a carrier and whose other end projects in an unsupported manner from the carrier ; and having a first roll mount and a second roll mount separate from the first roll mount , with the first roll mount being configured to engage into a first end of the label roll, and with the second roll mount being configured to engage into a second end of the label roll such that the label roll is receivable between the two roll mounts , wherein the second roll mount can be pushed onto the holding mandrel from the unsupported end of the holding mandrel , and wherein the first roll mount comprises a first mount section to engage into the first end of the label roll and the second roll mount comprises a second mount section to engage into the second end of the label roll,
A method for producing a change in the properties of a medium disposed in an artificial container, comprising: placing in a vicinity of the medium at least an energy modulation agent, wherein said energy modulation agent is configured to emit light into the medium upon interaction with an initiation energy, i.e. is capable of receiving an energy input from an initiation energy source and then re-emitting a different energy to a receiving target; and applying the initiation energy from an energy source to the medium, wherein the applied initiation energy interacts with a plasmonics agent, if present, or with the energy modulation agent to directly or indirectly, i.e. in a manner so that the initiation energy interacts with an energy modulation agent, which activates an activatable agent, produce the change in the properties of the medium, wherein optionally a plasmonics agent is placed in a vicinity of the medium, wherein said plasmonics agent 1) enhances or modifies said light from the energy modulation agent or 2) enhances or modifies the initiation energy, wherein said energy modulation agent is selected from the group consisting of fluorescent molecules, luminescent molecules or phosphorescent molecules, wherein the plasmonics agent comprises metal structures, wherein said activatable agent is an agent that normally exists in an inactive state in the absence of an activation signal and which is capable of being activated by an activation signal under activating conditions, wherein the activated activatable agent is capable of producing said change in the properties of said medium. placing in a vicinity of the medium at least an energy modulation agent, wherein said energy modulation agent is configured to emit light into the medium upon interaction with an initiation energy, i.e. is capable of receiving an energy input from an initiation energy source and then re-emitting a different energy to a receiving target; and applying the initiation energy from an energy source to the medium,
A solid oral pharmaceutical dosage form, selected from the group consisting of tablets and capsules, comprising a drug which is N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate in an amount selected from: 0.5 mg, 1 mg, and 2 mg, by weight of N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide.
An augment for implantation in association with an orthopedic implant device in a bone , the augment comprising: an augment wall having an outer portion , an inner portion , a distal end , and a proximal end , the inner portion defining an inner region of the augment , the inner region sized to receive placement of one or more components of the orthopedic implant device , the distal end of the augment wall having a first shape configured to generally conform to the shape of a metaphyseal-diaphyseal junction of a canal of the bone , the proximal end at the outer portion having a second shape configured to generally conform to a shape of the metaphyseal region of the canal of the bone , the first shape having a different shape and size than the second shape; at least one relief positioned about at least one of the proximal and distal ends of the augment wall , at least one of the reliefs being adapted to prevent, when the augment is implanted in the bone , point contact between a portion of the augment wall and an adjacent wall of the bone ; characterized in that the at least one relief comprises a relief wall that has a profile inwardly tapered toward the associated one of the proximal end and the distal end of the augment wall to reduce a size of a profile of the augment . an augment wall having an outer portion , an inner portion , a distal end , and a proximal end , the inner portion defining an inner region of the augment , the inner region sized to receive placement of one or more components of the orthopedic implant device , the distal end of the augment wall having a first shape configured to generally conform to the shape of a metaphyseal-diaphyseal junction of a canal of the bone , the proximal end at the outer portion having a second shape configured to generally conform to a shape of the metaphyseal region of the canal of the bone , the first shape having a different shape and size than the second shape; at least one relief positioned about at least one of the proximal and distal ends of the augment wall , at least one of the reliefs being adapted to prevent, when the augment is implanted in the bone , point contact between a portion of the augment wall and an adjacent wall of the bone ; characterized in that the at least one relief comprises a relief wall that has a profile inwardly tapered toward the associated one of the proximal end and the distal end of the augment wall to reduce a size of a profile of the augment .
An automotive pipe suitable for being mounted on an automobile (C) comprising: an inner pipe portion through which a fluid passes; an outer pipe portion surrounding a part of the inner pipe portion ; and a restricting portion configured to restrict the outer pipe portion from moving in an axial direction thereof, wherein at least an outer circumferential surface of the inner pipe portion facing the outer pipe portion is made of a resin, characterized in that the inner pipe portion includes a core portion made of a metal and a resin layer coating an outer circumference of the core portion , and the width (W) of a gap between the inner pipe portion and the outer pipe portion is smaller than a thickness (D) of the resin layer . an inner pipe portion through which a fluid passes; an outer pipe portion surrounding a part of the inner pipe portion ; and a restricting portion configured to restrict the outer pipe portion from moving in an axial direction thereof, wherein at least an outer circumferential surface of the inner pipe portion facing the outer pipe portion is made of a resin, characterized in that the inner pipe portion includes a core portion made of a metal and a resin layer coating an outer circumference of the core portion , and the width (W) of a gap between the inner pipe portion and the outer pipe portion is smaller than a thickness (D) of the resin layer .
A method for enhancing the amount of oil recoverable from an oil-bearing formation, wherein the method comprises applying to the formation: a yeast fermentation product that comprises broth resulting from cultivation of Wickerhamomyces anomalus or Starmerella bombicola yeast; and further comprising administering ammonium hydroxide to the formation; wherein the yeast in the yeast fermentation product is in an inactive form.
A pulley assembly for raising and lowering an associated vehicle body, said pulley assembly comprising: a housing including an outer sleeve extending along an axis (A); at least one top pulley wheel operably connected to said outer sleeve ; at least one bottom pulley wheel operably connected to said outer sleeve and moveable relative to said at least one top pulley wheel along said axis (A); a cable weaved between said at least one top pulley wheel and said at least one bottom pulley wheel ; and an actuator operably connected to said cable to reel-in said cable and draw said at least one top pulley wheel relative to and towards said at least one bottom pulley wheel along said axis (A) to lower said associated vehicle body and to reel-out said cable to permit said at least one top pulley wheel to move relative to and away from said at least one bottom pulley wheel to raise said associated vehicle body, characterized in that said at least one top pulley wheel is connected to an upper mounting ring and said at least one bottom pulley wheel is connected to a lower mounting ring , wherein one of said upper mounting ring and said lower mounting ring is slidably connected to said outer sleeve and said other of said upper mounting ring and said lower mounting ring is statically connected to said outer sleeve . a housing including an outer sleeve extending along an axis (A); at least one top pulley wheel operably connected to said outer sleeve ; at least one bottom pulley wheel operably connected to said outer sleeve and moveable relative to said at least one top pulley wheel along said axis (A); a cable weaved between said at least one top pulley wheel and said at least one bottom pulley wheel ; and an actuator operably connected to said cable to reel-in said cable and draw said at least one top pulley wheel relative to and towards said at least one bottom pulley wheel along said axis (A) to lower said associated vehicle body and to reel-out said cable to permit said at least one top pulley wheel to move relative to and away from said at least one bottom pulley wheel to raise said associated vehicle body, characterized in that said at least one top pulley wheel is connected to an upper mounting ring and said at least one bottom pulley wheel is connected to a lower mounting ring , wherein one of said upper mounting ring and said lower mounting ring is slidably connected to said outer sleeve and said other of said upper mounting ring and said lower mounting ring is statically connected to said outer sleeve .
A woven fabric for composite reinforcement comprising: unidirectional fiber tows arranged parallel to each other in a sheet-like formation; and wherein each unidirectional fiber tow is comprised of a plurality of continuous fiber filaments, characterised in that it comprises strips of nonwoven fibers interlaced with the unidirectional fiber tows in a weaving pattern, wherein each strip of nonwoven fibers is self-supporting, is a single-layer material, which is not attached to another layer of fibers, and is comprised of randomly arranged and/or randomly oriented fibers. unidirectional fiber tows arranged parallel to each other in a sheet-like formation; and wherein each unidirectional fiber tow is comprised of a plurality of continuous fiber filaments, characterised in that it comprises strips of nonwoven fibers interlaced with the unidirectional fiber tows in a weaving pattern, wherein each strip of nonwoven fibers is self-supporting, is a single-layer material, which is not attached to another layer of fibers, and is comprised of randomly arranged and/or randomly oriented fibers.