mhurhangee/patent-ind-claim-en huggingface dataset:
An eye tracking system comprising: a display panel ; and a light guide (122, 301, 407, 501, 601, 801 901, 1101) configured to be disposed between a user eye and the display panel, the light guide comprising a transparent body having: a first surface, a second surface opposite the first surface, and a third surface between the first surface and the second surface such that the third surface connects the first surface to the second surface; the first surface composed of a substantially planar surface; and the second surface comprising a combiner region having a plurality of facets arranged along a plane having a non-zero angle relative to the first surface and configured to reflect light incident on a corresponding region of the first surface internally through the body toward the third surface, characterised in that the display panel is positioned beyond the second surface of the light guide and oriented toward the user eye, the display panel configured to provide electronic images to the user eye, and wherein visible light from the display panel passes through the combiner region. a display panel ; and a light guide (122, 301, 407, 501, 601, 801 901, 1101) configured to be disposed between a user eye and the display panel, the light guide comprising a transparent body having: a first surface, a second surface opposite the first surface, and a third surface between the first surface and the second surface such that the third surface connects the first surface to the second surface; the first surface composed of a substantially planar surface; and the second surface comprising a combiner region having a plurality of facets arranged along a plane having a non-zero angle relative to the first surface and configured to reflect light incident on a corresponding region of the first surface internally through the body toward the third surface, characterised in that the display panel is positioned beyond the second surface of the light guide and oriented toward the user eye, the display panel configured to provide electronic images to the user eye, and wherein visible light from the display panel passes through the combiner region. a first surface, a second surface opposite the first surface, and a third surface between the first surface and the second surface such that the third surface connects the first surface to the second surface; the first surface composed of a substantially planar surface; and the second surface comprising a combiner region having a plurality of facets arranged along a plane having a non-zero angle relative to the first surface and configured to reflect light incident on a corresponding region of the first surface internally through the body toward the third surface, characterised in that the display panel is positioned beyond the second surface of the light guide and oriented toward the user eye, the display panel configured to provide electronic images to the user eye, and wherein visible light from the display panel passes through the combiner region.
A method for producing or providing cells expressing a fusion protein of a marker protein and a cell endogenous target protein from the endogenous gene locus of the target protein, wherein the method comprises the following steps: a) transfecting the cells i) with a Cas9-encoding plasmid comprising a nucleic acid, which confers resistance to a first selection reagent, ii) with a circular donor plasmid comprising a) a first nucleic acid, which confers resistance to a second selection reagent, and b) a second nucleic acid, which is encoding the marker protein, whereby the second nucleic acid is flanked 3' and 5' by nucleic acids homologous to the integration site in the cell and whereby one of the flanking homologous nucleic acids is homologous to the terminal coding sequence of the target protein, iii) with a crRNA, and iv) with a tracrRNA, b) culturing the cells in the presence of the first and the second selection reagents, and c) selecting cells that perform cell division under the conditions of step b) and thereby providing cells that express the fusion protein of a marker protein and a cell-endogenous target protein. a) transfecting the cells i) with a Cas9-encoding plasmid comprising a nucleic acid, which confers resistance to a first selection reagent, ii) with a circular donor plasmid comprising a) a first nucleic acid, which confers resistance to a second selection reagent, and b) a second nucleic acid, which is encoding the marker protein, whereby the second nucleic acid is flanked 3' and 5' by nucleic acids homologous to the integration site in the cell and whereby one of the flanking homologous nucleic acids is homologous to the terminal coding sequence of the target protein, iii) with a crRNA, and iv) with a tracrRNA, i) with a Cas9-encoding plasmid comprising a nucleic acid, which confers resistance to a first selection reagent, ii) with a circular donor plasmid comprising a) a first nucleic acid, which confers resistance to a second selection reagent, and b) a second nucleic acid, which is encoding the marker protein, whereby the second nucleic acid is flanked 3' and 5' by nucleic acids homologous to the integration site in the cell and whereby one of the flanking homologous nucleic acids is homologous to the terminal coding sequence of the target protein, a) a first nucleic acid, which confers resistance to a second selection reagent, and b) a second nucleic acid, which is encoding the marker protein, whereby the second nucleic acid is flanked 3' and 5' by nucleic acids homologous to the integration site in the cell and whereby one of the flanking homologous nucleic acids is homologous to the terminal coding sequence of the target protein, iii) with a crRNA, and iv) with a tracrRNA, b) culturing the cells in the presence of the first and the second selection reagents, and c) selecting cells that perform cell division under the conditions of step b) and thereby providing cells that express the fusion protein of a marker protein and a cell-endogenous target protein.
A control device for controlling at least one actuator (4a; 4b) for actuating braking means of a vehicle, more particularly of a rail vehicle, - in which, proceeding from an actual value of a current brake pressure (p B ) or a current contact force (F B ), measured by means of a first sensor (7a; 7b), of the at least one actuator (4a; 4b) for pressing against the braking means, a contact variable control system determines a manipulated variable (ST 1 ) for the at least one actuator (4a; 4b) in accordance with a setpoint value stipulated for this purpose, and - in which, proceeding from an actual value of a current deceleration force (Fv) or a current deceleration torque (Mv) at the braking means, which is measured by means of a second sensor (8a; 8b), a braking torque control system determines a manipulated variable (ST 2 ) for the at least one actuator (4a; 4b) in accordance with a setpoint value stipulated for this purpose, characterized in that a cascaded control system is provided for contact variable control and braking torque control, in which system - the contact variable control system is arranged in a contact variable control unit (5a; 5b) and forms an inner control circuit, and in that - the braking torque control system is arranged in a braking torque control unit embodied thereby and forms an outer control circuit, wherein - the outer control circuit carries out control of the at least one actuator (4a; 4b) in a manner which is prioritized over the inner control circuit, wherein furthermore - the outer control circuit can be switched off under particular operating conditions of the vehicle, with the result that the inner control circuit controls the at least one actuator (4a; 4b). - in which, proceeding from an actual value of a current brake pressure (p B ) or a current contact force (F B ), measured by means of a first sensor (7a; 7b), of the at least one actuator (4a; 4b) for pressing against the braking means, a contact variable control system determines a manipulated variable (ST 1 ) for the at least one actuator (4a; 4b) in accordance with a setpoint value stipulated for this purpose, and - in which, proceeding from an actual value of a current deceleration force (Fv) or a current deceleration torque (Mv) at the braking means, which is measured by means of a second sensor (8a; 8b), a braking torque control system determines a manipulated variable (ST 2 ) for the at least one actuator (4a; 4b) in accordance with a setpoint value stipulated for this purpose, - the contact variable control system is arranged in a contact variable control unit (5a; 5b) and forms an inner control circuit, and in that - the braking torque control system is arranged in a braking torque control unit embodied thereby and forms an outer control circuit, wherein - the outer control circuit carries out control of the at least one actuator (4a; 4b) in a manner which is prioritized over the inner control circuit, wherein furthermore - the outer control circuit can be switched off under particular operating conditions of the vehicle, with the result that the inner control circuit controls the at least one actuator (4a; 4b).
A narrow beam divergence semiconductor source operable to generate a beam having a substantially narrow beam divergence, an emission wavelength, and a substantially uniform beam intensity, the narrow beam divergence semiconductor source comprising: an optical resonant cavity including a high reflection mirror having first and second sides, an extended length mirror having first and second sides, and an active region; the high reflection mirror and the extended length mirror being disposed on distal sides of the active region such that the first side of the high reflection mirror is coupled to a first side of the active region and the first side of the extended length mirror is coupled to a second side of the active region opposing the first; and a plurality of electrical contacts operable to direct electric current to the active region, characterized in that the extended length mirror comprises a narrow bandwidth mirror and a high-reflectivity mirror , the narrow bandwidth mirror having a narrower bandwidth than the high-reflectivity mirror and the high-reflectivity mirror having a higher reflectivity than the narrow bandwidth mirror . an optical resonant cavity including a high reflection mirror having first and second sides, an extended length mirror having first and second sides, and an active region; the high reflection mirror and the extended length mirror being disposed on distal sides of the active region such that the first side of the high reflection mirror is coupled to a first side of the active region and the first side of the extended length mirror is coupled to a second side of the active region opposing the first; and a plurality of electrical contacts operable to direct electric current to the active region, characterized in that the extended length mirror comprises a narrow bandwidth mirror and a high-reflectivity mirror , the narrow bandwidth mirror having a narrower bandwidth than the high-reflectivity mirror and the high-reflectivity mirror having a higher reflectivity than the narrow bandwidth mirror .
An in vitro cell-based screening method to identify compounds effective in the treatment of cancer characterized by cells that are characterized by an over-activated signalling pathway, in a combination medicament with an inhibitor of said signalling pathway comprising the steps of a) providing a cell that carries an activating mutation or amplification in a gene encoding a protein comprised in said signalling pathway; b) bringing said cell in contact with i. an inhibitor of said signalling pathway; and ii. a test compound; c) determining an expression level of SOX2 and/or a gene under transcriptional control of SOX2; and d) assigning to said test compound a score, wherein i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold; wherein the gene under transcriptional control of SOX2 is selected from the group consisting of Nanog, OCT4, FGF4, FBX15, FOXP4, KLF9, CD24, CD271, CD36, ITLN2, TNFSF12, NOX3, CLEC7A, ACYAP1, UNC5C, UNC5D, MUC16, VAV3, FOXD3, VGLL3, ALPP, C3, F2R, ENPP2, ETV4, NTNG1, NTRK2, ROBO1 and ROBO2. a) providing a cell that carries an activating mutation or amplification in a gene encoding a protein comprised in said signalling pathway; b) bringing said cell in contact with i. an inhibitor of said signalling pathway; and ii. a test compound; i. an inhibitor of said signalling pathway; and ii. a test compound; c) determining an expression level of SOX2 and/or a gene under transcriptional control of SOX2; and d) assigning to said test compound a score, wherein i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold; i. said score is high if said expression level of SOX2 and/or said gene under transcriptional control of SOX2 is below a predetermined threshold, said threshold corresponding to an expression level of SOX2 and/or of said gene under transcriptional control of SOX2 in a control cell treated solely with said inhibitor of said signalling pathway; ii. said score is low if said expression level of SOX2 and/or of said gene under transcriptional control of SOX2 is equal to or above said predetermined threshold;
A matrix direct AC/AC converter comprising a three-phase input , which can be supplied with a three-phase input voltage (VE), a three-phase output , which can be applied to an electrical load , a plurality of electronic two-way switching devices , which are arranged so as to matrix-connect the terminals of the three-phase input with the terminals of the three-phase output , and control means for controlling the switching devices ; said control means being designed to receive a first reference voltage (VREF), which represents a desired three-phase voltage on the three-phase output , and said control means comprising first processing means for generating a common-mode voltage (VCM) and second processing means for generating a second reference voltage (VREFC) by combining the first reference voltage (VREF) with the common-mode voltage (VCM); the matrix direct AC/AC converter being characterized in that said control means comprise voltage and current measuring means for obtaining first measured values (VEM) corresponding to the three-phase input voltage (VE) and second measured values (ILM) corresponding to the three-phase load current (IL), and third processing means for processing the first measured values (VEM) in such a way as to obtain a first signal (VEmax), a second signal (VEmid), and a third signal (VEmin), which represent maximum values, intermediate values, and minimum values, respectively, of the phases of the three-phase input voltage (VE), in that said first processing means are designed to generate said common-mode voltage (VCM) as a function of the first reference voltage (VREF), of the first and second measured values (VEM, ILM) and of said first, second, and third signals (VEmax, VEmid, VEmin), and in that said control means comprise fourth processing means for processing said first, second, and third signals (VEmax, VEmid, VEmin) and the second reference voltage (VREFC) in such a way as to obtain pulse-width-modulated internal control signals (PWMI), referring to said first, second, and third signals, and fifth processing means for generating, starting from the internal control signals (PWMI) and as a function of a comparison between said first measured values (VEM), pulse-width-modulated external control signals (PWM), each of which is designed to control a respective two-way switch .
A soybean plant or plant part comprising: (i) a transgene that decreases the expression of an endogenous soybean FAD2-1 gene, wherein DNA sequences in the transgene resulting in an increased proportion of oleate consist of a soybean FAD2-1 coding region that is a fraction of a FAD2-1 sequence that does not encode a protein with FAD2 enzymatic activity; and (ii) at least one loss-of-function mutation in an endogenous soybean FAD3 gene. (i) a transgene that decreases the expression of an endogenous soybean FAD2-1 gene, wherein DNA sequences in the transgene resulting in an increased proportion of oleate consist of a soybean FAD2-1 coding region that is a fraction of a FAD2-1 sequence that does not encode a protein with FAD2 enzymatic activity; and (ii) at least one loss-of-function mutation in an endogenous soybean FAD3 gene.
Jack-up crane vessel or semi-submersible crane vessel comprising a hull with a deck , and a crane on the hull for hoisting a load outside the deck , wherein the crane comprises a slewing crane base that is rotatable with respect to the hull around a vertical rotation axis (Z), an elongated boom that is rotatable around a horizontal rotation axis (X) with respect to the crane base , at least two pendants between the boom and the crane base , a boom spacer between the boom and the crane base , and a boom luffing installation for driving the rotation of the boom around the horizontal rotation axis (X) between a lowered transport position and a raised operational position, wherein the crane base comprises a slew platform and a base frame above the slew platform that forms a first suspension of the crane base for the boom , wherein the boom comprises a distal boom section with a boom tip and a proximal boom section with a boom heel , wherein the pendants have a first end that is connected with the first suspension and an opposite second end that is connected with the distal boom section , wherein the pendants mutually converge toward the distal boom section , wherein the boom spacer has a first end that is rotatable connected with the first suspension for rotation around the horizontal rotation axis (X), and an opposite second end that is spaced apart from the first end and that is connected with the boom heel to keep the boom spaced apart from the horizontal rotation axis (X), and wherein in the direction of the vertical rotation axis (Z) the first suspension extends at least in the lowered transport position of the boom above the boom heel of the boom .
A Ziegler- Natta pro-catalyst composition for the polymerization of propylene to produce polypropylene with reduced polymer-fines, comprising a reaction product of (i) at least one titanium compound of the molecular formula TiX n (OR 1 ) 4-n , wherein n is an integer from 0 to 4, X is halogen, R 1 is independently selected from the group consisting of C 1 to C 10 alkyl group; (ii) at least one magnesium containing precursor of molecular formula Mg(OR 2 )(OR 3 ), wherein R 2 and R 3 are identical or different, and independently selected from the group consisting of C 1 to C 10 alkyl groups, C 1 to C 6 aryl group and C 1 to C 10 alkylaryl group; and (iii) at least one internal electron donor selected from the group of compounds consisting of dicarboxylic acid ester, monocarboxylic acid ester, diethers, silyl esters, amides, carbonates, and succinates; said pro-catalyst composition containing iron below 100 ppm.
A method performed after locking a first clock of a computing device to synchronize with a second clock associated with a first device , wherein a difference between the first clock and the second clock is determined during the locking, the method comprising: measuring, by the computing device , a path delay to a second device based on sending one or more messages including one or more first timestamps of the first clock to the second device and receiving one or more messages including one or more second timestamps of a third clock from the second device ; and sending, by the computing device , a third message to the second device that includes a third timestamp of the first clock that has been locked to the second clock by the exchange of messages between the computing device and the first device using a timestamp of the first clock and a timestamp of the second clock, wherein the third message includes the path delay, and wherein the third timestamp and the path delay allow the second device to analyze a lock quality of the first clock to the second clock based on a time of the third clock; wherein the path delay is inserted in the third message in a correction field of the third message. measuring, by the computing device , a path delay to a second device based on sending one or more messages including one or more first timestamps of the first clock to the second device and receiving one or more messages including one or more second timestamps of a third clock from the second device ; and sending, by the computing device , a third message to the second device that includes a third timestamp of the first clock that has been locked to the second clock by the exchange of messages between the computing device and the first device using a timestamp of the first clock and a timestamp of the second clock, wherein the third message includes the path delay, and wherein the third timestamp and the path delay allow the second device to analyze a lock quality of the first clock to the second clock based on a time of the third clock; wherein the path delay is inserted in the third message in a correction field of the third message.