A prosthetic mitral valve coaptation enhancement device for implanting at the native mitral valve region of a heart , the native mitral valve having a native annulus and native valve leaflets , the prosthetic mitral valve coaptation enhancement device comprising: a main body consisting of a tubular stentframe and a valve element attached thereto, the main body comprising a length and a lumen being defined by a proximal end and a distal end , and configured for placement within the native valve region of the heart , the tubular stentframe being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state, wherein the main body has a sealing section and a valve-bearing section , the valve- bearing section carrying the valve element ; characterized in that the shape of the sealing section of the main body , in the compressed state, has a form that is adapted to the coaptation zone of the native mitral valve during systole, and that in the sealing section of the main body , the radial rigidity of the tubular stentframe is lower than the radial rigidity of the valve-bearing section ; and that the prosthetic mitral valve coaptation enhancement device further comprises at least one anchoring element , which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart , and that the tubular stentframe in the sealing section consists of a flexible structure such, that, in the compressed state, it conforms to the coaptation zone of the native mitral valve during systole, wherein the tubular stentframe , in the sealing section , has a flexibility and rigidity that is lower than the flexibility and rigidity of the valve-bearing section , and in that the prosthetic mitral valve coaptation enhancement device has a size enabling the sealing section being positionable at the level of the native mitral valve leaflets and the valve-bearing section being positionable distally in the left ventricle or proximally in the left atrium . a main body consisting of a tubular stentframe and a valve element attached thereto, the main body comprising a length and a lumen being defined by a proximal end and a distal end , and configured for placement within the native valve region of the heart , the tubular stentframe being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state, wherein the main body has a sealing section and a valve-bearing section , the valve- bearing section carrying the valve element ; characterized in that the shape of the sealing section of the main body , in the compressed state, has a form that is adapted to the coaptation zone of the native mitral valve during systole, and that in the sealing section of the main body , the radial rigidity of the tubular stentframe is lower than the radial rigidity of the valve-bearing section ; and that the prosthetic mitral valve coaptation enhancement device further comprises at least one anchoring element , which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart , and that the tubular stentframe in the sealing section consists of a flexible structure such, that, in the compressed state, it conforms to the coaptation zone of the native mitral valve during systole, wherein the tubular stentframe , in the sealing section , has a flexibility and rigidity that is lower than the flexibility and rigidity of the valve-bearing section , and in that the prosthetic mitral valve coaptation enhancement device has a size enabling the sealing section being positionable at the level of the native mitral valve leaflets and the valve-bearing section being positionable distally in the left ventricle or proximally in the left atrium . <EOS>