mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody-drug conjugate of Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing, wherein: A is an anti-ErbB2 antibody, wherein the anti-ErbB2 antibody is Trastuzumab, optionally wherein the Lys at the end of the heavy chain is deleted, or fragment thereof; XisN; Y is N or CR 1 , and R 1 is H or C 1 -C 10 alkyl; L is a divalent linker selected from the group consisting of: wherein each of m and n is an integer selected from the group consisting of 1-10, preferably 1, 2, 3, 4, 5 or 6 at each occurrence; D is a cytotoxic agent group of Formula (D1) or (D2) or a stereoisomer thereof: wherein: R 2 is selected from the group consisting of -CH 2 N 3 , -CONHSO 2 (cyclopropyl), thiazol-2-yl, -CH 3 and -COOH; R 3 is selected from the group consisting of H and -OH; and R 4 is selected from the group consisting of H, -NH 2 , Cl, Br, I, -OS(O) 2 R 6 , wherein R 6 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl or C 6 -C 14 aryl, and the alkyl, cycloalkyl and aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4 or 5) substituents selected from halogens such as F; wherein: R 5 is selected from the group consisting of -C(CH 3 )N(CH 3 )C(O)CH 2 CH 2 SH and -C(CH 3 )N(CH 3 )C(O)CH 2 C(CH 3 ) 2 SH; and a is an integer selected from the group consisting of 2-10. A is an anti-ErbB2 antibody, wherein the anti-ErbB2 antibody is Trastuzumab, optionally wherein the Lys at the end of the heavy chain is deleted, or fragment thereof; XisN; Y is N or CR 1 , and R 1 is H or C 1 -C 10 alkyl; L is a divalent linker selected from the group consisting of: wherein each of m and n is an integer selected from the group consisting of 1-10, preferably 1, 2, 3, 4, 5 or 6 at each occurrence; D is a cytotoxic agent group of Formula (D1) or (D2) or a stereoisomer thereof: wherein: R 2 is selected from the group consisting of -CH 2 N 3 , -CONHSO 2 (cyclopropyl), thiazol-2-yl, -CH 3 and -COOH; R 3 is selected from the group consisting of H and -OH; and R 4 is selected from the group consisting of H, -NH 2 , Cl, Br, I, -OS(O) 2 R 6 , wherein R 6 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl or C 6 -C 14 aryl, and the alkyl, cycloalkyl and aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4 or 5) substituents selected from halogens such as F; wherein: R 5 is selected from the group consisting of -C(CH 3 )N(CH 3 )C(O)CH 2 CH 2 SH and -C(CH 3 )N(CH 3 )C(O)CH 2 C(CH 3 ) 2 SH; and R 2 is selected from the group consisting of -CH 2 N 3 , -CONHSO 2 (cyclopropyl), thiazol-2-yl, -CH 3 and -COOH; R 3 is selected from the group consisting of H and -OH; and R 4 is selected from the group consisting of H, -NH 2 , Cl, Br, I, -OS(O) 2 R 6 , wherein R 6 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl or C 6 -C 14 aryl, and the alkyl, cycloalkyl and aryl are each optionally substituted with one or more (e.g., 1, 2, 3, 4 or 5) substituents selected from halogens such as F; a is an integer selected from the group consisting of 2-10.
A method for synchronizing timing related to a secondary component carrier, SCC, in carrier aggregated wireless networks, comprising: determining an out-of-synchronization status with respect to the SCC utilized to communicate with an eNodeB; signaling an indication of the out-of-synchronization status to the eNodeB; and performing a random access procedure with the eNodeB to synchronize timing for communicating over the SCC. determining an out-of-synchronization status with respect to the SCC utilized to communicate with an eNodeB; signaling an indication of the out-of-synchronization status to the eNodeB; and performing a random access procedure with the eNodeB to synchronize timing for communicating over the SCC.
A method for antenna pattern shaping of a geostationary communications satellite in orbit, the satellite having a reconfigurable faceted reflector and an antenna feed for illuminating the reconfigurable faceted reflector, the method comprising: receiving data describing a desired coverage area; determining, based on the orbital position of the satellite and the desired coverage area , optimal positions for a plurality of flat reflector facets for radiating the desired antenna pattern, wherein the plurality of reflector facets are coupled to a plurality of adjusting mechanisms, each adjusting mechanism is an actuator , for adjusting the positions of the plurality of reflector facets, and the plurality of adjusting mechanisms are mounted to a concave backing structure , the actuators extending substantially perpendicular to the backing structure, the reflector facets forming a reflector surface that is generally concave; and adjusting, while the satellite is in orbit, using the plurality of adjusting mechanisms, by linearly translating the positions of the plurality of reflector facets to the determined optimal positions for the plurality of reflector facets. receiving data describing a desired coverage area; determining, based on the orbital position of the satellite and the desired coverage area , optimal positions for a plurality of flat reflector facets for radiating the desired antenna pattern, wherein the plurality of reflector facets are coupled to a plurality of adjusting mechanisms, each adjusting mechanism is an actuator , for adjusting the positions of the plurality of reflector facets, and the plurality of adjusting mechanisms are mounted to a concave backing structure , the actuators extending substantially perpendicular to the backing structure, the reflector facets forming a reflector surface that is generally concave; and adjusting, while the satellite is in orbit, using the plurality of adjusting mechanisms, by linearly translating the positions of the plurality of reflector facets to the determined optimal positions for the plurality of reflector facets.
A method performed by a wireless device for performing a transmission at a changed Coverage Enhancement, CE, level in a random access procedure, wherein the wireless device and a network node operate in a wireless communications network , and wherein the method comprises: - receiving a random access order from the network node , wherein the random access order indicates a first preamble and a first carrier to be used; - transmitting , to the network node , the first preamble on the first carrier using one or more attempts out of a number of attempts associated with a first CE level; - in the absence of a valid response from the network node after a number of transmissions corresponding to a number of attempts associated with the first CE level, determining a second CE level that is different from the first CE level, selecting , in a predictable way for the network node , a carrier that is supporting the second CE level, and transmitting , to the network node , a preamble on the carrier using one or more attempts out of a number of attempts associated with the second CE level; and wherein the selecting of the carrier comprises selecting the carrier using a pre-defined function known by the network node . - receiving a random access order from the network node , wherein the random access order indicates a first preamble and a first carrier to be used; - transmitting , to the network node , the first preamble on the first carrier using one or more attempts out of a number of attempts associated with a first CE level; - in the absence of a valid response from the network node after a number of transmissions corresponding to a number of attempts associated with the first CE level,
Covering device for at least regionally closing an underwater opening in a hull of a watercraft , in particular an opening of a transverse channel of a thruster , wherein the covering device has at least one variable-volume hollow-chamber lip , which is able to be set into an expanded state or into a contracted state by the feeding or the discharging of a fluid , in particular air , wherein the hollow-chamber lip is constructed with a fluid-tight and flexible sheet-like structure , characterized in that the hollow-chamber lip comprises at least one buoyancy body , the buoyancy of which supports a transition from the expanded state into the contracted state of the hollow-chamber lip , wherein the at least one buoyancy body is arranged in the region of the free end of the hollow-chamber lip and has a lower density than water.
A copolymer of ethylene with silane groups containing comonomer that is produced in a high pressure radical polymerisation process comprising the steps of: (a) compressing ethylene together with the silane groups containing comonomer under pressure in a compressor, wherein a compressor lubricant is used for lubrication, (b) polymerising ethylene together with the silane groups containing comonomer in a polymerisation zone, (c) separating the obtained ethylene from the unreacted products and recovering the separated ethylene copolymer in a recovery zone, wherein in step a) the compressor lubricant comprises a mineral oil and contains no polyalkyleneglycol based components; wherein the ethylene copolymer has a silane groups containing comonomer content of 0.5 to 3wt% and an MFR2 measured in accordance with ISO 1133 at 190°C and a load of 2.16 kg of 0.3 to 10 g/10min, and the copolymer of ethylene with silane groups containing comonomer is crosslinked with a condensation reaction catalyst that is acidic, suitably a Brönsted acid. (a) compressing ethylene together with the silane groups containing comonomer under pressure in a compressor, wherein a compressor lubricant is used for lubrication, (b) polymerising ethylene together with the silane groups containing comonomer in a polymerisation zone, (c) separating the obtained ethylene from the unreacted products and recovering the separated ethylene copolymer in a recovery zone, wherein in step a) the compressor lubricant comprises a mineral oil and contains no polyalkyleneglycol based components; wherein the ethylene copolymer has a silane groups containing comonomer content of 0.5 to 3wt% and an MFR2 measured in accordance with ISO 1133 at 190°C and a load of 2.16 kg of 0.3 to 10 g/10min, and the copolymer of ethylene with silane groups containing comonomer is crosslinked with a condensation reaction catalyst that is acidic, suitably a Brönsted acid.
A driver system for driving a plurality of LED's , the driver system comprising: a control module (C) having an input for receiving operating data, and at least two driver modules (D), wherein the control module (C) and the driver modules (D) are interconnected by a bus structure, each driver module (D) for driving a respective at least one of the LED's, each driver module comprising a converter for generating a current to power the respective at least one of the LED's, and a controller electrically connected to the converter for controlling the converter, characterized in that the control module is arranged to test a first one of the driver modules by activating the converter of the first one of the driver modules and requesting from each driver module a current measurement in order to detect if the activation of the first one of the driver modules results in a current path to another one of the driver modules due to wiring errors. a control module (C) having an input for receiving operating data, and at least two driver modules (D), wherein the control module (C) and the driver modules (D) are interconnected by a bus structure, each driver module (D) for driving a respective at least one of the LED's, each driver module comprising a converter for generating a current to power the respective at least one of the LED's, and a controller electrically connected to the converter for controlling the converter, characterized in that the control module is arranged to test a first one of the driver modules by activating the converter of the first one of the driver modules and requesting from each driver module a current measurement in order to detect if the activation of the first one of the driver modules results in a current path to another one of the driver modules due to wiring errors.
An air traffic control system with improved switchover characteristics, wherein the air traffic control system comprises at least two air traffic control radios , wherein the at least two air traffic control radios comprise a main radio and a backup radio such that the at least two air traffic control radios establish a failover group , and wherein the air traffic control system comprises a voice data buffer that is configured to buffer data associated with voice signals received, characterized in that the voice data buffer has an overall buffer capacity and an initial buffer capacity being a portion of the overall buffer capacity, wherein the air traffic control system is configured to initiate a switchover from the main radio to the backup radio in case of failure of the main radio , and wherein the switchover from the main radio to the backup radio is completed when the initial buffer capacity of the voice data buffer is filled.
A method for data feedback processing, applied to a first terminal, the method comprising: determining (S31) a plurality of second terminals as feedback receiving terminals, upon determining that feedback is required to be provided in a first time slot for first data sent by the plurality of second terminals; determining (S32) whether the first terminal supports simultaneous feedback; and determining (S33), according to a service priority level upon determining that the first terminal does not support simultaneous feedback, a target terminal having the highest service priority level from the plurality of feedback receiving terminals, and sending, in the first time slot, feedback information to the target terminal having the highest service priority level, wherein the feedback information is configured to indicate a receiving status of the first terminal for the first data. determining (S31) a plurality of second terminals as feedback receiving terminals, upon determining that feedback is required to be provided in a first time slot for first data sent by the plurality of second terminals; determining (S32) whether the first terminal supports simultaneous feedback; and determining (S33), according to a service priority level upon determining that the first terminal does not support simultaneous feedback, a target terminal having the highest service priority level from the plurality of feedback receiving terminals, and sending, in the first time slot, feedback information to the target terminal having the highest service priority level, wherein the feedback information is configured to indicate a receiving status of the first terminal for the first data.
An apparatus comprising: a light conversion element comprising: an input interface for receiving input light ; an output interface for providing output light having at least one different, lower frequency than the input light ; and a plurality of light guides extending between the input interface and the output interface that are housing down-conversion material at remote locations from the input interface, wherein the down-conversion material is configured to down-convert the received input light to produce the provided output light of lower frequency or frequencies; wherein, the down-conversion material is housed in cavities in the light guides , remote from and thermally insulated from the input interface . a light conversion element comprising: an input interface for receiving input light ; an output interface for providing output light having at least one different, lower frequency than the input light ; and a plurality of light guides extending between the input interface and the output interface that are housing down-conversion material at remote locations from the input interface, wherein the down-conversion material is configured to down-convert the received input light to produce the provided output light of lower frequency or frequencies; an input interface for receiving input light ; an output interface for providing output light having at least one different, lower frequency than the input light ; and a plurality of light guides extending between the input interface and the output interface that are housing down-conversion material at remote locations from the input interface, wherein the down-conversion material is configured to down-convert the received input light to produce the provided output light of lower frequency or frequencies; wherein, the down-conversion material is housed in cavities in the light guides , remote from and thermally insulated from the input interface .
A method for measuring a fiber orientation degree comprising: a diffraction image acquisition process of irradiating a sample formed of a composite material containing discontinuous carbon fibers with an X-ray to acquire an X-ray diffraction image, characterized in that the method comprises: a peak angle calculation process of calculating an angle (2θ) A of a peak originating from a crystal face of graphite from an inflection point A of an integral value I(2θ) obtained by integrating the X-ray diffraction image with respect to an azimuth angle (φ); a correction coefficient calculation process of calculating a correction coefficient δ of a thickness of the sample, wherein the correction coefficient calculation process includes calculating the correction coefficient δ by Formula below: δ = 2 θ A − tan − 1 1 − t / L ⋅ tan 2 θ A in Expression , t indicates a thickness (mm) of the sample, and L indicates a distance (mm) from an incident plane of the X-ray of the sample to a film surface on which the X-ray diffraction image is projected; an upper limit calculation process of calculating an upper limit (2θ) B of the peak of the crystal face of graphite from an inflection point B of the integral value I(2θ); a diffraction sensitivity calculation process of calculating a diffraction sensitivity I c (φ) of the peak originating from the crystal face of graphite by correcting an integrating range with the correction coefficient δ and integrating the X-ray diffraction image with respect to a diffraction angle (2θ); and an orientation degree calculation process of calculating a fiber orientation degree Sd(β) by the method of Hermans from the diffraction sensitivity I c (φ). a peak angle calculation process of calculating an angle (2θ) A of a peak originating from a crystal face of graphite from an inflection point A of an integral value I(2θ) obtained by integrating the X-ray diffraction image with respect to an azimuth angle (φ); a correction coefficient calculation process of calculating a correction coefficient δ of a thickness of the sample, wherein the correction coefficient calculation process includes calculating the correction coefficient δ by Formula below: δ = 2 θ A − tan − 1 1 − t / L ⋅ tan 2 θ A in Expression , t indicates a thickness (mm) of the sample, and L indicates a distance (mm) from an incident plane of the X-ray of the sample to a film surface on which the X-ray diffraction image is projected; an upper limit calculation process of calculating an upper limit (2θ) B of the peak of the crystal face of graphite from an inflection point B of the integral value I(2θ); a diffraction sensitivity calculation process of calculating a diffraction sensitivity I c (φ) of the peak originating from the crystal face of graphite by correcting an integrating range with the correction coefficient δ and integrating the X-ray diffraction image with respect to a diffraction angle (2θ); and an orientation degree calculation process of calculating a fiber orientation degree Sd(β) by the method of Hermans from the diffraction sensitivity I c (φ).
A multi-mode phased array antenna, MPAA, having at least two modes of operation, wherein a first mode of operation produces a first radiation pattern having a main-beam and a second mode of operation produces a second radiation pattern having a second beam, the MPAA comprising: a plurality of radiating elements arranged as an array of radiating elements, and a controller in signal communication with the plurality of radiating elements , wherein the controller is configured to excite the plurality of radiating elements to produce the first radiation pattern having the main-beam in the first mode of operation and the second radiation pattern having the second beam in the second mode of operation, wherein the second beam is wider than the main-beam; and wherein the second radiation pattern approximates a radiation pattern of a single radiating element of the plurality of radiating elements , wherein the controller is also configured to switch between the first mode operation and the second mode of operation, wherein the controller is configured to excite the plurality of radiating elements by determining a plurality of excitation signals for the plurality of radiating elements and wherein the plurality of excitation signals for the second radiation pattern are determined by utilizing a truncated regular series expansion of Bessel functions for an electromagnetic, EM, field of a single point source and equating the truncated regular series expansion of Bessel functions for EM field to an array response for the MPAA . a plurality of radiating elements arranged as an array of radiating elements, and a controller in signal communication with the plurality of radiating elements , wherein the controller is configured to excite the plurality of radiating elements to produce the first radiation pattern having the main-beam in the first mode of operation and the second radiation pattern having the second beam in the second mode of operation, wherein the second beam is wider than the main-beam; and wherein the second radiation pattern approximates a radiation pattern of a single radiating element of the plurality of radiating elements , wherein the controller is also configured to switch between the first mode operation and the second mode of operation, wherein the controller is configured to excite the plurality of radiating elements by determining a plurality of excitation signals for the plurality of radiating elements and wherein the plurality of excitation signals for the second radiation pattern are determined by utilizing a truncated regular series expansion of Bessel functions for an electromagnetic, EM, field of a single point source and equating the truncated regular series expansion of Bessel functions for EM field to an array response for the MPAA .
A reel arrangement with a main reel and a secondary reel on a common reel axis and with a cable to be wound up, wherein the cable runs from a stationary first cable end via a cable loop to the secondary reel in order to be wound up and unwound there, wherein the cable is then guided to the main reel and is fastened to the main reel and/or the secondary reel , the secondary reel has a smaller winding diameter (D2) than the main reel , wherein the cable loop is under the influence of a gravity-induced tensioning force directed against the winding direction of the secondary reel , characterized in that , to generate the tensioning force, a weight body is connected to the cable loop so as to be displaceable in the longitudinal direction of the cable , wherein the secondary reel is spirally wound and the main reel is cylindrically wound, wherein the tensioning force pulls on the cable loop in such a way that the cable is always properly spirally wound.