A biopsy tissue handling apparatus , comprising: a tissue holder assembly comprising a tray defining a tissue storage compartment ; a tube defining a vacuum lumen in communication with the tissue storage compartment , the tube being configured to receive a severed tissue specimen and deliver the severed tissue specimen with a fluid through the vacuum lumen so that the severed tissue specimen and the fluid are deposited into the tissue storage compartment ; an x-ray imaging system arranged relative to the tissue storage compartment to acquire an x-ray image of the severed tissue specimen and the fluid in the tissue storage compartment , the x-ray image depicting internal structures of the severed tissue specimen and external or surface portions of the severed tissue specimen; an optical camera imaging system arranged relative to the tissue storage compartment to acquire an optical image of the severed tissue specimen and the fluid in the tissue storage compartment , the optical image depicting only external or surface portions of the severed tissue specimen; an image processor in communication with the x-ray imaging system and the optical camera imaging system , the image processor being configured to receive the x-ray image and the optical image , detect an edge of the severed tissue specimen depicted in the optical image , and generate a hybrid image based at least in part upon the x-ray image , the optical image , and the detected edge of the severed tissue specimen depicted in the optical image , wherein a transparency of a portion of the optical image corresponding to the edge compensates for fluid attenuation of the edge depicted in the x-ray image during x-ray image acquisition; and a display in communication with the image processor , the hybrid image being presented to a user of the biopsy tissue handling apparatus through the display . a tissue holder assembly comprising a tray defining a tissue storage compartment ; a tube defining a vacuum lumen in communication with the tissue storage compartment , the tube being configured to receive a severed tissue specimen and deliver the severed tissue specimen with a fluid through the vacuum lumen so that the severed tissue specimen and the fluid are deposited into the tissue storage compartment ; an x-ray imaging system arranged relative to the tissue storage compartment to acquire an x-ray image of the severed tissue specimen and the fluid in the tissue storage compartment , the x-ray image depicting internal structures of the severed tissue specimen and external or surface portions of the severed tissue specimen; an optical camera imaging system arranged relative to the tissue storage compartment to acquire an optical image of the severed tissue specimen and the fluid in the tissue storage compartment , the optical image depicting only external or surface portions of the severed tissue specimen; an image processor in communication with the x-ray imaging system and the optical camera imaging system , the image processor being configured to receive the x-ray image and the optical image , detect an edge of the severed tissue specimen depicted in the optical image , and generate a hybrid image based at least in part upon the x-ray image , the optical image , and the detected edge of the severed tissue specimen depicted in the optical image , wherein a transparency of a portion of the optical image corresponding to the edge compensates for fluid attenuation of the edge depicted in the x-ray image during x-ray image acquisition; and a display in communication with the image processor , the hybrid image being presented to a user of the biopsy tissue handling apparatus through the display . <EOS>