mhurhangee/patent-ind-claim-en huggingface dataset:
A genetically-modified human T cell comprising in its genome a cassette comprising, from 5' to 3': (a) a promoter; (b) a nucleic acid sequence encoding a chimeric antigen receptor (CAR); (c) a 2A sequence; (d) a nucleic acid sequence encoding an HLA class I histocompatibility antigen, alpha chain E (HLA-E) fusion protein, wherein said HLA-E fusion protein comprises an amino acid sequence of SEQ ID NO: 66, and wherein an intron sequence is positioned within said nucleic acid sequence encoding said HLA-E fusion protein, wherein said intron sequence comprises a nucleic acid sequence of SEQ ID NO: 69, and wherein a nucleic acid sequence encoding a microRNA-adapted shRNA (shRNAmiR) is positioned within said intron sequence, wherein said nucleic acid sequence encoding said shRNAmiR comprises SEQ ID NO: 46; and (e) a termination signal; wherein said nucleic acid sequence encoding said CAR, said nucleic acid sequence encoding said HLA-E fusion protein, and said nucleic acid sequence encoding said shRNAmiR are operably linked to said promoter, and wherein said cassette is positioned within a T cell receptor (TCR) alpha constant region gene. (a) a promoter; (b) a nucleic acid sequence encoding a chimeric antigen receptor (CAR); (c) a 2A sequence; (d) a nucleic acid sequence encoding an HLA class I histocompatibility antigen, alpha chain E (HLA-E) fusion protein, wherein said HLA-E fusion protein comprises an amino acid sequence of SEQ ID NO: 66, and wherein an intron sequence is positioned within said nucleic acid sequence encoding said HLA-E fusion protein, wherein said intron sequence comprises a nucleic acid sequence of SEQ ID NO: 69, and wherein a nucleic acid sequence encoding a microRNA-adapted shRNA (shRNAmiR) is positioned within said intron sequence, wherein said nucleic acid sequence encoding said shRNAmiR comprises SEQ ID NO: 46; and (e) a termination signal; wherein said nucleic acid sequence encoding said CAR, said nucleic acid sequence encoding said HLA-E fusion protein, and said nucleic acid sequence encoding said shRNAmiR are operably linked to said promoter, and wherein said cassette is positioned within a T cell receptor (TCR) alpha constant region gene.
A piece of furniture for air purification and in the form of a substantially closed cabinet comprising • a) at least one upper purpose tray , which preferably has a rectangular outline, • b) side walls in vertical alignment below this tray, • c) at least one opening in the top part of the side walls , which allows air (A) to enter the inside of the cabinet, • d) at least one opening in the bottom part of the cabinet, preferably behind the side walls , which allows the filtered air (B) to exit the cabinet, • e) at least one electrical power source, • f) at least one air overpressurization means connected to the power source and allowing the air to flow through the cabinet, • g) at least one horizontally positioned filter , parallel to the upper purpose tray and located upstream of the air overpressurization means , • h) at least one vertically positioned filter , perpendicular to the upper purpose tray and located downstream of the air overpressurization means , which is at least 3 cm away from the nearest side wall , • i) at least one duct between the at least one filter located downstream of the air overpressurization means and the nearest side wall , which duct allows the filtered air to be discharged towards the opening of the bottom part of the cabinet. • a) at least one upper purpose tray , which preferably has a rectangular outline, • b) side walls in vertical alignment below this tray, • c) at least one opening in the top part of the side walls , which allows air (A) to enter the inside of the cabinet, • d) at least one opening in the bottom part of the cabinet, preferably behind the side walls , which allows the filtered air (B) to exit the cabinet, • e) at least one electrical power source, • f) at least one air overpressurization means connected to the power source and allowing the air to flow through the cabinet, • g) at least one horizontally positioned filter , parallel to the upper purpose tray and located upstream of the air overpressurization means , • h) at least one vertically positioned filter , perpendicular to the upper purpose tray and located downstream of the air overpressurization means , which is at least 3 cm away from the nearest side wall , • i) at least one duct between the at least one filter located downstream of the air overpressurization means and the nearest side wall , which duct allows the filtered air to be discharged towards the opening of the bottom part of the cabinet.
A fastening unit for pipe joints, comprising a plastic material support structure having at least one seat for a respective pipe joint formed on at least one wall of the structure and delimiting a respective opening , the at least one seat being closed by a respective closing tab , integrally formed with the structure to form a monolithic piece ; the tab having a weakened breaking line joining the tab to the respective seat and defining a tear-off opening for removing the tab from the seat so as to form the respective opening ; characterized in that said at least one seat has a perimeter edge shaped so as to define a bayonet, and/or interlocking and/or snap coupling for coupling to the respective pipe joint.
A machine for preparing liquid food products, in particular via capsules , comprising at least: - a source of a liquid; - a delivery assembly , having a brewing chamber configured for receiving a precursor of a liquid food product, in particular a precursor contained in a capsule , and for delivering the food product following upon passage of the liquid through the brewing chamber ; - a pump , for pumping the liquid from the source through the brewing chamber of the delivery assembly and thereby causing delivery of the food product; and - a control system , configured for controlling an electric motor of the pump having a rotating shaft , wherein the pump has a pump casing with an inlet and an outlet , and a pumping arrangement designed to be driven by the motor , the machine being characterized in that : - the motor is a bidirectional motor, and the control system comprises means (I) for controlling reversal of the direction of rotation of the motor between a primary direction (F) and a secondary direction (B); - the pump has a priming system comprising a recirculation valve (60-63) and a corresponding actuation arrangement ; and - the actuation arrangement is pre-arranged for causing opening of the recirculation valve (60-63) following upon rotation of the motor in the secondary direction (B). - a source of a liquid; - a delivery assembly , having a brewing chamber configured for receiving a precursor of a liquid food product, in particular a precursor contained in a capsule , and for delivering the food product following upon passage of the liquid through the brewing chamber ; - a pump , for pumping the liquid from the source through the brewing chamber of the delivery assembly and thereby causing delivery of the food product; and - a control system , configured for controlling an electric motor of the pump having a rotating shaft , - the motor is a bidirectional motor, and the control system comprises means (I) for controlling reversal of the direction of rotation of the motor between a primary direction (F) and a secondary direction (B); - the pump has a priming system comprising a recirculation valve (60-63) and a corresponding actuation arrangement ; and - the actuation arrangement is pre-arranged for causing opening of the recirculation valve (60-63) following upon rotation of the motor in the secondary direction (B).
An impregnation cream comprising: - water, - at least one emulsifier and - at least one polydimethylsiloxane selected from: HO-(SiMe 2 O) n -H and Me 3 SiO-(SiMe 2 O) n -SiMe 3 , wherein n is an integer from 20 to 2500, wherein the impregnation cream being free from hydrocarbons, alkoxylated silanes, alkoxylated siloxanes and amine group-functionalized siloxanes. - water, - at least one emulsifier and - at least one polydimethylsiloxane selected from: HO-(SiMe 2 O) n -H and Me 3 SiO-(SiMe 2 O) n -SiMe 3 , wherein n is an integer from 20 to 2500, wherein the impregnation cream being free from hydrocarbons, alkoxylated silanes, alkoxylated siloxanes and amine group-functionalized siloxanes. HO-(SiMe 2 O) n -H and Me 3 SiO-(SiMe 2 O) n -SiMe 3 , wherein n is an integer from 20 to 2500, wherein the impregnation cream being free from hydrocarbons, alkoxylated silanes, alkoxylated siloxanes and amine group-functionalized siloxanes.
A tool for forming a wax pattern as part of an investment casting process, the tool comprising: a tool body comprising a flexible member defining a desired outer surface geometry of the wax pattern ; a ceramic core disposed within the tool body, the core forming part of the wax pattern after a wax injection step; a means for supporting the core within the tool body; and a reactive element disposed within the flexible member , wherein the reactive element comprises one of the group consisting of a magnet, particles reactive to magnetic energy, and particles exhibiting a coefficient of thermal conductivity different than a coefficient of thermal conductivity of flexible material of the flexible member surrounding the particles . a tool body comprising a flexible member defining a desired outer surface geometry of the wax pattern ; a ceramic core disposed within the tool body, the core forming part of the wax pattern after a wax injection step; a means for supporting the core within the tool body; and a reactive element disposed within the flexible member , wherein the reactive element comprises one of the group consisting of a magnet, particles reactive to magnetic energy, and particles exhibiting a coefficient of thermal conductivity different than a coefficient of thermal conductivity of flexible material of the flexible member surrounding the particles .
A device for creating a track use plan comprising: a selector configured to select a schedule line of a target train to which a track of a station is to be allocated out of a plurality of the schedule lines included in a schedule of the station; and an allocator configured to allocate, to the schedule line of the target train, the track according to a track condition indicating an attribute of a train allocatable to the track, the track condition being a condition that includes a train classification of the train and a destination of the train; characterized in that the allocator is further configured to allocate, to the schedule line of the target train, the track having a shortest operation headway out of a plurality of the tracks on the basis of an operation headway on each track between the target train and a preceding train preceding the target train when the track is not able to be allocated to the schedule line of the target train according to the track condition. a selector configured to select a schedule line of a target train to which a track of a station is to be allocated out of a plurality of the schedule lines included in a schedule of the station; and an allocator configured to allocate, to the schedule line of the target train, the track according to a track condition indicating an attribute of a train allocatable to the track, the track condition being a condition that includes a train classification of the train and a destination of the train; characterized in that the allocator is further configured to allocate, to the schedule line of the target train, the track having a shortest operation headway out of a plurality of the tracks on the basis of an operation headway on each track between the target train and a preceding train preceding the target train when the track is not able to be allocated to the schedule line of the target train according to the track condition. allocate, to the schedule line of the target train, the track according to a track condition indicating an attribute of a train allocatable to the track, the track condition being a condition that includes a train classification of the train and a destination of the train; characterized in that the allocator is further configured to allocate, to the schedule line of the target train, the track having a shortest operation headway out of a plurality of the tracks on the basis of an operation headway on each track between the target train and a preceding train preceding the target train when the track is not able to be allocated to the schedule line of the target train according to the track condition.
A computer implemented method, when run on a controller, comprising the steps of: determining an upper threshold temperature; determining a lower threshold temperature; receiving a temperature outside a rack enclosure from a temperature sensor configured to sense the temperature outside the rack enclosure; when the temperature outside the rack enclosure is greater than or equal/greater than said upper threshold temperature powering on an air conditioner disposed within the rack enclosure and powering off at least one fan configured to provide airflow through the rack enclosure, and when the temperature outside the rack enclosure is less than or equal/less than said lower threshold temperature powering off the air conditioner, and powering on the at least one fan; and characterised by comprising the steps of: receiving temperature and humidity inside the rack enclosure from a temperature and humidity sensor configured to sense the temperature and humidity inside the rack enclosure; and controlling operation of the air conditioner disposed within the rack enclosure, based at least on the temperature and humidity inside the rack enclosure. determining an upper threshold temperature; determining a lower threshold temperature; receiving a temperature outside a rack enclosure from a temperature sensor configured to sense the temperature outside the rack enclosure; when the temperature outside the rack enclosure is greater than or equal/greater than said upper threshold temperature powering on an air conditioner disposed within the rack enclosure and powering off at least one fan configured to provide airflow through the rack enclosure, and when the temperature outside the rack enclosure is less than or equal/less than said lower threshold temperature powering off the air conditioner, and powering on the at least one fan; and characterised by comprising the steps of: receiving temperature and humidity inside the rack enclosure from a temperature and humidity sensor configured to sense the temperature and humidity inside the rack enclosure; and controlling operation of the air conditioner disposed within the rack enclosure, based at least on the temperature and humidity inside the rack enclosure. receiving temperature and humidity inside the rack enclosure from a temperature and humidity sensor configured to sense the temperature and humidity inside the rack enclosure; and controlling operation of the air conditioner disposed within the rack enclosure, based at least on the temperature and humidity inside the rack enclosure.
Method for producing a lawn surface on a support of any kind, wherein said support is covered with a geotextile , a thickness ( d ) of a layer of sand sufficient for the development of grass seeds is spread, grass seeds are uniformly distributed in said layer of sand , a thickness ( d' ) of a layer of soil sufficient for the development of the grass seeds is spread, grass seeds are uniformly distributed in said layer of soil , the layer of soil is compacted, said layers of sand and soil are kept moist.
A method comprising: causing , at least in part, to present a first content on a first display ; receiving an input for activating one or more second displays ; causing, at least in part, to automatically select a second content based, at least in part, on the first content and the input specifying activation of said one or more second displays; and causing, at least in part, to present the second content on the one or more second displays, wherein selection of the second content is based on parsing or analyzing content of the first display to determine identifiable characteristics in the first content, said identifiable characteristics used to search for and identify at least one of a related application, service or content for display on at least one or more second displays. causing , at least in part, to present a first content on a first display ; receiving an input for activating one or more second displays ; causing, at least in part, to automatically select a second content based, at least in part, on the first content and the input specifying activation of said one or more second displays; and causing, at least in part, to present the second content on the one or more second displays, wherein selection of the second content is based on parsing or analyzing content of the first display to determine identifiable characteristics in the first content, said identifiable characteristics used to search for and identify at least one of a related application, service or content for display on at least one or more second displays.
A method for facilitating selection of content for broadcasting in a television broadcast system , comprising: receiving a first request , at a bridging system , in a broadcasting based format from a television broadcast system in response to a first marker in a transmission log indicating that a time window is opened, wherein the first request is for content to be broadcast by the television broadcast system during the time window in which the transmission log does not define or schedule a specific advertising content to be broadcast; sending, from the bridging system , a second request for content in a computer based format to a network-based content selection system intermittently at a predefined time interval until a confirmation is received indicating that a selected content has been broadcasted, or until an indication to stop requesting content is received, wherein the indication to stop requesting content is received in response to a second marker in a transmission log indicating that the time window is closed; selecting, by the content selection system , content in response to the second request; receiving, at the bridging system , a content identifier associated with the selected content from the network-based content selection system ; and sending the content identifier , from the bridging system , to the television broadcast system for broadcasting the selected content. receiving a first request , at a bridging system , in a broadcasting based format from a television broadcast system in response to a first marker in a transmission log indicating that a time window is opened, wherein the first request is for content to be broadcast by the television broadcast system during the time window in which the transmission log does not define or schedule a specific advertising content to be broadcast; sending, from the bridging system , a second request for content in a computer based format to a network-based content selection system intermittently at a predefined time interval until a confirmation is received indicating that a selected content has been broadcasted, or until an indication to stop requesting content is received, wherein the indication to stop requesting content is received in response to a second marker in a transmission log indicating that the time window is closed; selecting, by the content selection system , content in response to the second request; receiving, at the bridging system , a content identifier associated with the selected content from the network-based content selection system ; and sending the content identifier , from the bridging system , to the television broadcast system for broadcasting the selected content.
An automated system for use in well control , the system comprising: a controller configured to receive an input signal indicative of a fluid flow rate or fluid volumetric rate from a wellbore , the controller configured to determine from said input signal whether the fluid flow rate or fluid volumetric rate exceeds a preselected threshold indicative of a fluid influx condition in the wellbore system, wherein, on determining that said fluid flow rate or fluid volumetric rate exceeds said preselected threshold, the controller is configured to automatically output one or more command signals initiating an initial well control protocol, wherein the initial well control protocol comprises a well shut-in protocol, the initial well control protocol comprising one or more preselected well control operations actioned based on preselected criteria without requiring an operative to decide and/or action said required initial well control operations, and wherein the system is configured for coupling to, to communicate with, or is operatively associated with components of an oil and/or gas installation, the system configured for coupling to, to communicate with or being operatively associated with a drawworks of the oil and/or gas installation , the initial well control protocol comprising a command signal to the drawworks to automatically raise the drill string off the bottom of the wellbore , characterised by a drawworks space out configuration comprising calibrated set points for movement of the drawworks set during set up of the system . a controller configured to receive an input signal indicative of a fluid flow rate or fluid volumetric rate from a wellbore , the controller configured to determine from said input signal whether the fluid flow rate or fluid volumetric rate exceeds a preselected threshold indicative of a fluid influx condition in the wellbore system, wherein, on determining that said fluid flow rate or fluid volumetric rate exceeds said preselected threshold, the controller is configured to automatically output one or more command signals initiating an initial well control protocol, wherein the initial well control protocol comprises a well shut-in protocol, the initial well control protocol comprising one or more preselected well control operations actioned based on preselected criteria without requiring an operative to decide and/or action said required initial well control operations, and wherein the system is configured for coupling to, to communicate with, or is operatively associated with components of an oil and/or gas installation, the system configured for coupling to, to communicate with or being operatively associated with a drawworks of the oil and/or gas installation , the initial well control protocol comprising a command signal to the drawworks to automatically raise the drill string off the bottom of the wellbore , characterised by a drawworks space out configuration comprising calibrated set points for movement of the drawworks set during set up of the system .
An anti-CGRP receptor antibody or antigen-binding fragment thereof for use in (a) a method for preventing or reducing the occurrence of migraine headache in a patient in need thereof, or (b) a method for prophylactically treating a patient for migraine wherein the method comprises administering to the patient the anti-CGRP receptor antibody or antigen-binding fragment thereof at a dose of about 35 mg to about 210 mg once per month, wherein the anti-CGRP receptor antibody or antigen-binding fragment thereof comprises a CDRH1 having the sequence of SEQ ID NO:14, a CDRH2 having the sequence of SEQ ID NO:23, a CDRH3 having the sequence of SEQ ID NO:34, a CDRL1 having the sequence of SEQ ID NO:44, a CDRL2 having the sequence of SEQ ID NO:55, and a CDRL3 having the sequence of SEQ ID NO:65. (a) a method for preventing or reducing the occurrence of migraine headache in a patient in need thereof, or (b) a method for prophylactically treating a patient for migraine