mhurhangee/patent-ind-claim-en huggingface dataset:
A cover for use in negative-pressure therapy, comprising: a backing layer comprising a film layer having a first side and a second side; a switchable adhesive comprising photosensitive agents disposed on the first side of the film layer , the switchable adhesive having: a first bond strength, a second bond strength in response to crosslinking the adhesive, the second bond strength being greater than the first bond strength, and a third bond strength in response to further crosslinking of the adhesive by exposing the photosensitive agents to electromagnetic radiation in an ultraviolet light spectrum, the third bond strength being less than the second bond strength; and a filter layer releasably coupled to the second side of the film layer opposite the switchable adhesive, the filter layer configured to block at least a portion of the electromagnetic radiation in the ultraviolet light spectrum. a backing layer comprising a film layer having a first side and a second side; a switchable adhesive comprising photosensitive agents disposed on the first side of the film layer , the switchable adhesive having: a first bond strength, a second bond strength in response to crosslinking the adhesive, the second bond strength being greater than the first bond strength, and a third bond strength in response to further crosslinking of the adhesive by exposing the photosensitive agents to electromagnetic radiation in an ultraviolet light spectrum, the third bond strength being less than the second bond strength; and a first bond strength, a second bond strength in response to crosslinking the adhesive, the second bond strength being greater than the first bond strength, and a third bond strength in response to further crosslinking of the adhesive by exposing the photosensitive agents to electromagnetic radiation in an ultraviolet light spectrum, the third bond strength being less than the second bond strength; and a filter layer releasably coupled to the second side of the film layer opposite the switchable adhesive, the filter layer configured to block at least a portion of the electromagnetic radiation in the ultraviolet light spectrum.
A compound of the formula: 6'-(( E )-2-((3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-1-oxooctahydro isobenzofuran-4-yl)vinyl)-[3,3'-bipyridine]-2-carbonitrile; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-((E)-2-(2'-phenyl-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-4-(( E )-2-(2'-methoxy-[3,3'-bipyridin]-6-yl)vinyl)-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-chloro-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-fluoro-[3,3'-biyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-cyclopropyl-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-(( E )-2-(2'-(5-methylthiophen-2-yl)-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-(( E )-2-(2'-(1-methyl-1H-imidazol-5-yl)-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-(3,3-difluoroazetidin-1-yl)-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; or a pharmaceutically acceptable salt thereof. 6'-(( E )-2-((3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-1-oxooctahydro isobenzofuran-4-yl)vinyl)-[3,3'-bipyridine]-2-carbonitrile; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-((E)-2-(2'-phenyl-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-4-(( E )-2-(2'-methoxy-[3,3'-bipyridin]-6-yl)vinyl)-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-chloro-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-fluoro-[3,3'-biyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-cyclopropyl-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-(( E )-2-(2'-(5-methylthiophen-2-yl)-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-6,6-difluoro-7a-hydroxy-3,5-dimethyl-4-(( E )-2-(2'-(1-methyl-1H-imidazol-5-yl)-[3,3'-bipyridin]-6-yl)vinyl)hexahydroisobenzofuran-1 -one; (3 R ,3a R ,4 R ,5 S ,7a S )-4-(( E )-2-(2'-(3,3-difluoroazetidin-1-yl)-[3,3'-bipyridin]-6-yl)vinyl)-6,6-difluoro-7a-hydroxy-3,5-dimethylhexahydroisobenzofuran-1 -one; or a pharmaceutically acceptable salt thereof.
A method for purifying an immunoglobulin, comprising the steps of: (a) dissolving immunoglobulin-containing plasma protein fraction l + ll + lll or fraction II + III , followed by performing a precipitation reaction by adding caprylic acid; (b) removing a precipitate produced from (a), followed by filtering a supernatant comprising immunoglobulin, concentrating a filtrate, subjecting a concentrate to an anion exchange chromatography, and recovering a fraction not attached to column of the anion exchange chromatography; (c) treating the recovered fraction with a solvent/detergent to inactivate viruses, followed by subjecting the fraction to cation exchange chromatography to remove the solvent/detergent, wherein the cation-exchange chromatography is carried out by using a ceramic based cation exchange resin, wherein the cation exchange chromatography is performed at a salt concentration of 400-600 mM; (d) dialyzing and/or concentrating an eluate obtained from the cation exchange chromatography, subjecting the eluate to anion exchange chromatography, and recovering a fraction not attached to column of the anion-exchange chromatography, wherein a salt concentration of the eluate obtained from the cation exchange chromatography column in the step (c) is maintained at 50-150 mM in order to maintain the content of polymers during dialysis and/or concentration; and (e) filtering the recovered fraction through a virus filter, and dialyzing and/or concentrating the filtrate, thereby obtaining a purified immunoglobulin. (a) dissolving immunoglobulin-containing plasma protein fraction l + ll + lll or fraction II + III , followed by performing a precipitation reaction by adding caprylic acid; (b) removing a precipitate produced from (a), followed by filtering a supernatant comprising immunoglobulin, concentrating a filtrate, subjecting a concentrate to an anion exchange chromatography, and recovering a fraction not attached to column of the anion exchange chromatography; (c) treating the recovered fraction with a solvent/detergent to inactivate viruses, followed by subjecting the fraction to cation exchange chromatography to remove the solvent/detergent, wherein the cation-exchange chromatography is carried out by using a ceramic based cation exchange resin, wherein the cation exchange chromatography is performed at a salt concentration of 400-600 mM; (d) dialyzing and/or concentrating an eluate obtained from the cation exchange chromatography, subjecting the eluate to anion exchange chromatography, and recovering a fraction not attached to column of the anion-exchange chromatography, wherein a salt concentration of the eluate obtained from the cation exchange chromatography column in the step (c) is maintained at 50-150 mM in order to maintain the content of polymers during dialysis and/or concentration; and (e) filtering the recovered fraction through a virus filter, and dialyzing and/or concentrating the filtrate, thereby obtaining a purified immunoglobulin.
A downhole screen (405") comprising a pipe (425") and a plurality of ceramic discs (470") stacked on each other around the pipe (425"), wherein the pipe (425") comprises a plurality of ports (440"), wherein at least one spacer (499") is provided between each two adjacent discs (470") such that adjacent discs (470") are spaced from one another, and wherein the/each spacer (499") is aligned with a respective port (440") of the plurality of ports (440") in the pipe (425") and shaped to diffuse fluid flow exiting the port (440") in the pipe (425"). wherein the pipe (425") comprises a plurality of ports (440"), wherein at least one spacer (499") is provided between each two adjacent discs (470") such that adjacent discs (470") are spaced from one another, and wherein the/each spacer (499") is aligned with a respective port (440") of the plurality of ports (440") in the pipe (425") and shaped to diffuse fluid flow exiting the port (440") in the pipe (425").
A method of verifying map data that is being transmitted from a remote server to one or more map-based application(s) executing on an electronic control unit (ECU) of a vehicle traversing a navigable network covered by a digital map , wherein the digital map is represented as a set of plural map tiles , each map tile representing a particular geographical area including a portion of the navigable network, the method comprising: generating, at the server, a data structure for a map tile, wherein the data structure includes object data indicative of a set of one or more object(s) falling at least partially within the geographical area covered by the map tile and/or within the geographical area covered by another one or more of the map tile(s) representing the digital map, wherein, for at least one object in the set of one or more object(s) for which object data is included in the map tile data structure, associated object-level security data is included within the map tile data structure along with the object data for the at least one object, the object-level security data being usable for verifying the integrity of its associated object data ; and transmitting the data structure for the map tile including the object data and associated object-level security data from the server to a client application executing on one or more processing unit(s) of the vehicle , wherein the map tile data structure further has a digital signature for verifying the authenticity and/or integrity of the map tile data structure , the digital signature for the map tile data structure being applied by the server. generating, at the server, a data structure for a map tile, wherein the data structure includes object data indicative of a set of one or more object(s) falling at least partially within the geographical area covered by the map tile and/or within the geographical area covered by another one or more of the map tile(s) representing the digital map, wherein, for at least one object in the set of one or more object(s) for which object data is included in the map tile data structure, associated object-level security data is included within the map tile data structure along with the object data for the at least one object, the object-level security data being usable for verifying the integrity of its associated object data ; and transmitting the data structure for the map tile including the object data and associated object-level security data from the server to a client application executing on one or more processing unit(s) of the vehicle , wherein the map tile data structure further has a digital signature for verifying the authenticity and/or integrity of the map tile data structure , the digital signature for the map tile data structure being applied by the server.
A method of radio resource control in a communication network entity for supporting a communication between a terminal and a communication network that comprises said communication network entity , said communication between said communication network and said terminal being carried over one or more radio resources, said method comprising: supporting a radio resource control suspend operation comprising storing respective radio resource control information related to a configured connected state of said terminal , said radio resource control information comprising radio resource configuration information associated with a set of radio resources associated with said configured connected state, supporting a radio resource control resume operation comprising using the stored radio resource control information for resuming the connected state of said terminal, performing an admission control process during said radio resource control resume operation, said admission control process comprising a procedure for examining whether said connected state is to be resumed according to the stored radio resource configuration information or if a radio resource reconfiguration procedure is to be performed for resuming the connected state. supporting a radio resource control suspend operation comprising storing respective radio resource control information related to a configured connected state of said terminal , said radio resource control information comprising radio resource configuration information associated with a set of radio resources associated with said configured connected state, supporting a radio resource control resume operation comprising using the stored radio resource control information for resuming the connected state of said terminal, performing an admission control process during said radio resource control resume operation, said admission control process comprising a procedure for examining whether said connected state is to be resumed according to the stored radio resource configuration information or if a radio resource reconfiguration procedure is to be performed for resuming the connected state.
A road stud including a reflector having a reflective surface, wherein the road stud includes a patterned surface configured to direct rainwater falling on the road stud to flow down over the reflective surface of the reflector ; wherein the patterned surface comprises a plurality of channels , each channel extending in a direction towards the reflective surface, and wherein the patterned surface is substantially flat and horizontal apart from the plurality of channels , the road stud characterised in that : each channel widens into a delta portion adjacent the reflector .
Points adjustment mechanism for two movable point tongues arranged between two opposing stock rails with a lock housing likewise arranged between the opposing stock rails , wherein: a) the lock housing is supported by a lock fastening arranged between the stock rails; b) the lock fastening can be fastened to two adjacently arranged sleeper bodies or to both flanges of a hollow sleeper ; c) a locking of the points adjustment mechanism by the interaction of a cam rod guided in a central lock support and at least one locking pawl pivotably mounted on the lock housing is achieved, wherein the pivot axis is aligned horizontally; d) the lock support is connected to the lock fastening ; e) starting from the lock housing by means of a tongue adjusting rod fastened to it and an adapter piece fastened to it, a point of attachment to the point tongue is provided, and f) the cam rod can be moved by a point machine between the two end positions of the point tongues . a) the lock housing is supported by a lock fastening arranged between the stock rails; b) the lock fastening can be fastened to two adjacently arranged sleeper bodies or to both flanges of a hollow sleeper ; c) a locking of the points adjustment mechanism by the interaction of a cam rod guided in a central lock support and at least one locking pawl pivotably mounted on the lock housing is achieved, wherein the pivot axis is aligned horizontally; d) the lock support is connected to the lock fastening ; e) starting from the lock housing by means of a tongue adjusting rod fastened to it and an adapter piece fastened to it, a point of attachment to the point tongue is provided, and f) the cam rod can be moved by a point machine between the two end positions of the point tongues .
Method of manufacturing a filling material for a pouched smokeless snus product, the method comprising the steps of: a) coating non-tobacco plant material with nicotine using a liquid nicotine-in-glycerol solution, wherein the nicotine is present in a concentration of 2 to 20 weight-% based on the total weight of the nicotine-in-glycerol solution; b) mixing the coated non-tobacco plant material with water and salt, preferably the salt is NaCl, and optionally uncoated non-tobacco plant material and/or tobacco material to form the filling material; c) optionally subjecting the filling material to a pasteurization step; and d) optionally mixing the product of step b) or c) with further ingredients, preferably the further ingredients comprise or consist of NH 4 Cl, Na 2 CO 3 , propylene glycol, optionally one or more flavours and/or combinations thereof. a) coating non-tobacco plant material with nicotine using a liquid nicotine-in-glycerol solution, wherein the nicotine is present in a concentration of 2 to 20 weight-% based on the total weight of the nicotine-in-glycerol solution; b) mixing the coated non-tobacco plant material with water and salt, preferably the salt is NaCl, and optionally uncoated non-tobacco plant material and/or tobacco material to form the filling material; c) optionally subjecting the filling material to a pasteurization step; and d) optionally mixing the product of step b) or c) with further ingredients, preferably the further ingredients comprise or consist of NH 4 Cl, Na 2 CO 3 , propylene glycol, optionally one or more flavours and/or combinations thereof.
A visualization system to graphically display performance and correctness features of an execution of a multi-threaded software program on a computing device, the visualization system comprising: a parser module to prepare program execution data recorded during the execution of the multi-threaded software program for visualization; a graphical modeler to display an animated graphical representation of the program execution data, the animated graphical representation highlighting one or more of the performance and correctness features; and a controller module to interactively control the display of the animated graphical representation on a display, characterized in that the parser module is arranged to read the program execution data from a plurality of log files generated by a memory race recording system during the execution of the multi-threaded software program, and to arrange the data according to chunks, wherein each chunk represents a plurality of instructions executed by the same thread without interleaving with a conflicting memory access, and in that the animated graphical representation includes data relating to the execution order of the chunks. a parser module to prepare program execution data recorded during the execution of the multi-threaded software program for visualization; a graphical modeler to display an animated graphical representation of the program execution data, the animated graphical representation highlighting one or more of the performance and correctness features; and a controller module to interactively control the display of the animated graphical representation on a display, characterized in that the parser module is arranged to read the program execution data from a plurality of log files generated by a memory race recording system during the execution of the multi-threaded software program, and to arrange the data according to chunks, wherein each chunk represents a plurality of instructions executed by the same thread without interleaving with a conflicting memory access, and in that the animated graphical representation includes data relating to the execution order of the chunks.
A method for isolating human cardiac ventricular progenitor cells, the method comprising: contacting a culture of human cells containing cardiac progenitor cells with one or more agents reactive with neuropilin-1 (NRP1); and separating NRP1 reactive positive cells from non-reactive cells to thereby isolate human cardiac ventricular progenitor cells. contacting a culture of human cells containing cardiac progenitor cells with one or more agents reactive with neuropilin-1 (NRP1); and separating NRP1 reactive positive cells from non-reactive cells to thereby isolate human cardiac ventricular progenitor cells.
Adjustable damping system for a vehicle seat for damping vibrations of a seat-part-side upper part relative to a body-side lower part in at least one spatial direction (X, Y, Z), wherein the adjustable damping system comprises an adjustment device , a damping element and a sensor device , wherein at least the damping element , arranged between the seat-part-side upper part and the body-side lower part and adjustable by the adjustment device , is provided for the damping, characterised in that at least one relative movement variable and a change in the relative movement variable of the seat-part-side upper part relative to the body-side lower part can be determined by the sensor device , and a first damping force of the damping element can be adjusted by the adjustment device as a function of the at least one relative movement variable and a frequency of the change in the relative movement variable, wherein the first damping force of the damping element is adjustable by the adjustment device as a function of a speed (V), an acceleration (B) and the jerk (R) of the seat-part-side upper part relative to the body-side lower part .