mhurhangee/patent-ind-claim-en huggingface dataset:
A method of predicting a therapeutic response to an anti-TNF therapy, which is a soluble TNF-receptor based protein therapy or an anti-TNF-alpha antibody therapy, in a patient suffering from a chronic inflammatory disease, comprising the steps of: a) obtaining a culture of immune cells from a biological sample collected from a patient prior to anti-TNF therapy, b) stimulating the culture with an agent that stimulates the innate or adaptive immune system, c) measuring the expression level of several different biomarkers induced by the stimulating agent at step b), and d) comparing the expression level of each biomarker measured at step c) with a reference value established by statistical analysis of values obtained from representative panels of individuals, wherein the detection of a higher or lower expression level of at least one of the biomarkers between the stimulated culture and the reference value indicates that the patient will be a responder to the anti-TNF therapy. a) obtaining a culture of immune cells from a biological sample collected from a patient prior to anti-TNF therapy, b) stimulating the culture with an agent that stimulates the innate or adaptive immune system, c) measuring the expression level of several different biomarkers induced by the stimulating agent at step b), and d) comparing the expression level of each biomarker measured at step c) with a reference value established by statistical analysis of values obtained from representative panels of individuals, wherein the detection of a higher or lower expression level of at least one of the biomarkers between the stimulated culture and the reference value indicates that the patient will be a responder to the anti-TNF therapy.
A powder material impregnation method comprising: a first step of dispersing a powder of a predetermined material in a liquid to prepare a slurry (K); and a second step of burying a molded fabric body made of fiber bundles in the slurry and vibrating the slurry by use of a plurality of vibrators (M) provided at predetermined intervals in a frame body the shape of which follows and is slightly larger than a cross-sectional shape of the molded fabric body; wherein, in the second step, the vibrator frame is moved along a side surface of the molded fabric body in a direction normal to the cross-sectional shape, so as to move over the whole side surface of the molded fabric body, and wherein the fiber material is one or more of non-oxide inorganic materials, oxide inorganic materials, and carbon. a first step of dispersing a powder of a predetermined material in a liquid to prepare a slurry (K); and a second step of burying a molded fabric body made of fiber bundles in the slurry and vibrating the slurry by use of a plurality of vibrators (M) provided at predetermined intervals in a frame body the shape of which follows and is slightly larger than a cross-sectional shape of the molded fabric body; wherein, in the second step, the vibrator frame is moved along a side surface of the molded fabric body in a direction normal to the cross-sectional shape, so as to move over the whole side surface of the molded fabric body, and wherein the fiber material is one or more of non-oxide inorganic materials, oxide inorganic materials, and carbon.
A computer-implemented method for adjusting the quality score of a genomic sequence base (S j ) in a genomic sequence read (S), the method comprising: performing a search for sequences within a determined or preselected distance of the genomic sequence read (S) in a genomic corpus comprising n-mers (R) from a reference genome for said genomic read, wherein said distance is a Hamming-distance or an edit-distance; based on the results of said search performing calculations of a new quality score for said genomic sequence base (S j ) in said read (S) by estimating the probability that the base (S j ) in the read (S) has a sequencing error (Pr(S j ≠ Z j | S)) as: Pr S j ≠ Z j | S ≈ ∑ k ∈ L Pr S j ≠ Z j | S , R k Pr S | R k + ε j 3 − m 3 ε j + 3 m − 4 mε j β ∑ i ∈ L Pr S | R i where L denotes the set of n-mers ( R k€L ) within said distance, m denotes a probability of mutation, e j denotes the probability of a read error at the base (S j ) and β is an estimate of the contribution of n-mers not within said distance; and replacing the old quality score with the new quality score if the new quality score is better than the old quality score. where L denotes the set of n-mers ( R k€L ) within said distance, m denotes a probability of mutation, e j denotes the probability of a read error at the base (S j ) and β is an estimate of the contribution of n-mers not within said distance; and replacing the old quality score with the new quality score if the new quality score is better than the old quality score.
Hybrid aerodyne including a fuselage , a fixed wing and a rotary wing capable of being immobilized in cruising flight of the aerodyne, the rotary wing being able to produce lift by its rotation in a vertical flight phase and to be immobilized and stored longitudinally in a cruise flight phase, of the type including at least one single-blade with a counterweight situated at the top and at the front of the fuselage , said single-blade being articulated about an axis perpendicular to the axis of rotation of the rotor, substantially at the level of said axis of rotation of the rotor mast, characterized in that it includes a means for allowing forward inclination of the rotor disk (R1) formed by said single-blade about the above-mentioned perpendicular axis and for limiting its backward inclination over a range of tilt at most equal to five degrees of angle.
A uterine manipulator comprising a deformable colpotomizer cup defining a receptacle sized to receive a cervix of a patient, wherein i) the deformable colpotomizer cup is formed of one or more reversibly deformable materials such that the colpotomizer cup is adjustable from a nominal width configuration to a reduced width configuration for insertion of the colpotomizer cup into a vaginal canal of the patient and adjustable to rebound from the reduced width configuration to the nominal width configuration for placement of the colpotomizer cup about the cervix, ii) the deformable colpotomizer cup has a wall thickness in a range of about 0.2 cm to about 0.7 cm, and iii) the deformable colpotomizer cup defines a plurality of viewing windows through which the cervix can be visualized, the plurality of viewing windows forming void spaces in the deformable colpotomizer cup . i) the deformable colpotomizer cup is formed of one or more reversibly deformable materials such that the colpotomizer cup is adjustable from a nominal width configuration to a reduced width configuration for insertion of the colpotomizer cup into a vaginal canal of the patient and adjustable to rebound from the reduced width configuration to the nominal width configuration for placement of the colpotomizer cup about the cervix, ii) the deformable colpotomizer cup has a wall thickness in a range of about 0.2 cm to about 0.7 cm, and iii) the deformable colpotomizer cup defines a plurality of viewing windows through which the cervix can be visualized, the plurality of viewing windows forming void spaces in the deformable colpotomizer cup .
An elevator installation system comprising: a support structure including a first surface and a second surface , the support structure oriented such that the first surface faces in a first direction and the second surface faces in a second direction opposite the first direction, the support structure configured to support a worker standing on the first surface ; a hoist supporting the support structure such that at least a portion of the hoist is positioned facing the second surface ; and a suspension member coupled to the hoist and extending from the hoist in the first direction characterised in that the support structure includes at least a portion of an elevator car, and wherein the elevator car includes an elevator cab and the elevator cab defines the second surface . a support structure including a first surface and a second surface , the support structure oriented such that the first surface faces in a first direction and the second surface faces in a second direction opposite the first direction, the support structure configured to support a worker standing on the first surface ; a hoist supporting the support structure such that at least a portion of the hoist is positioned facing the second surface ; and a suspension member coupled to the hoist and extending from the hoist in the first direction characterised in that the support structure includes at least a portion of an elevator car, and wherein the elevator car includes an elevator cab and the elevator cab defines the second surface .
A laundry appliance incorporating a recirculating fluid flow system , the recirculating fluid flow system comprising: a fluid pump that delivers process fluid through a fluid path ; a tub that defines a processing space , wherein the fluid path includes at least a portion of the processing space , the tub having an outlet that directs the process fluid toward the fluid pump , the tub being positioned within a cabinet having a door that provides access to the processing space of the tub ; and a sprayer assembly coupled with the tub for directing the process fluid into the processing space , characterised in that the sprayer assembly includes a spray head having a plurality of spray nozzles and an operable seam that extends through each spray nozzle of the plurality of spray nozzles , the operable seam being selectively separable to define a release opening that includes at least two spray nozzles of the plurality of spray nozzles . a fluid pump that delivers process fluid through a fluid path ; a tub that defines a processing space , wherein the fluid path includes at least a portion of the processing space , the tub having an outlet that directs the process fluid toward the fluid pump , the tub being positioned within a cabinet having a door that provides access to the processing space of the tub ; and a sprayer assembly coupled with the tub for directing the process fluid into the processing space ,
A method for wireless communication at a user equipment, UE, comprising: monitoring a control channel from a base station for a grant of resources of a communication channel over a plurality of aggregated transmission time intervals, TTIs; identifying a location of an excluded TTI within the plurality of aggregated TTIs, wherein the excluded TTI is to be excluded from the grant of resources and comprises one or more symbols semi-statically configured by the base station for an opposite link direction than at least one of the other TTIs in the plurality of aggregated TTIs; and communicating with the base station via the resources of the communication channel over at least a subset of the plurality of aggregated TTIs based at least in part on the grant and the identified location of the excluded TTI. monitoring a control channel from a base station for a grant of resources of a communication channel over a plurality of aggregated transmission time intervals, TTIs; identifying a location of an excluded TTI within the plurality of aggregated TTIs, wherein the excluded TTI is to be excluded from the grant of resources and comprises one or more symbols semi-statically configured by the base station for an opposite link direction than at least one of the other TTIs in the plurality of aggregated TTIs; and communicating with the base station via the resources of the communication channel over at least a subset of the plurality of aggregated TTIs based at least in part on the grant and the identified location of the excluded TTI.
A method, performed by a plurality of computing devices, comprising: implementing one or more programmatic interfaces enabling a client to request an imposition of a lower resource usage limit than an existing resource usage limit in effect at the time of the request at one or more service instances of a network-accessible service, wherein the lower resource usage limit is to be applied to at least one category of network traffic associated with the service; receiving a client request, via a particular interface of the one or more programmatic interfaces, indicating a particular lower resource usage limit to be imposed on network traffic at a particular service instance; obtaining resource usage metrics corresponding to one or more categories of network traffic at the particular service instance; and in response to determining that resource usage associated with network traffic at the particular service instance has reached a threshold level determined at least in part from the particular lower resource usage limit, initiating one or more responsive actions. implementing one or more programmatic interfaces enabling a client to request an imposition of a lower resource usage limit than an existing resource usage limit in effect at the time of the request at one or more service instances of a network-accessible service, wherein the lower resource usage limit is to be applied to at least one category of network traffic associated with the service; receiving a client request, via a particular interface of the one or more programmatic interfaces, indicating a particular lower resource usage limit to be imposed on network traffic at a particular service instance; obtaining resource usage metrics corresponding to one or more categories of network traffic at the particular service instance; and in response to determining that resource usage associated with network traffic at the particular service instance has reached a threshold level determined at least in part from the particular lower resource usage limit, initiating one or more responsive actions.
An apparatus for actuating a signal generator , in particular a radio key of a motor vehicle, comprising a signal generator receiver , movable between a closed position and an open position, for receiving the signal generator ; an actuation means for actuating the signal generator receivable in the signal generator receiver ; and a locking means for locking the signal generator receiver in the closed position, characterized in that the actuation means and the locking means form a structural unit.
Liquid cleansing composition comprising: a) 10 to 45% by wt., preferably 20 to 45%, more preferably 25 to 45% C 8 to C 20 , preferably C 10 to C 20 or C 12 to C 18 fatty acid or fatty acid soap (which includes 0.1 to 5% 12-HSA of subparagraph (c) below) wherein 45% to 65%, preferably 50 to 63%, more preferably 55 to 62% of the total fatty acid and fatty acid soap is C 14 myristic acid; b) less than 5% by wt. synthetic surfactant, preferably 1 to 3%; c) 0.1 to 5% by wt., preferably 0.5 to 4% by wt. 12-hydroxystearic acid (12-HSA), wherein the 0.1 to 5% 12-HSA is part of component (a); d) 20 to 50%, preferably 21 to 40% by wt. polyol; e) 0 to 5%, preferably 0.01 to 3%, preferably 0.03 to 2% by wt. cationic polymer; and f) balance water wherein the pH of said liquid cleanser composition is 8.0 to 11.0, preferably 8.5 to 10.0; and wherein the amount (wt%) of myristic acid is calculated according to the following formula: Myristic Acid Total FA + FA soap ∗ 100 = amount wt% of myristic acid . a) 10 to 45% by wt., preferably 20 to 45%, more preferably 25 to 45% C 8 to C 20 , preferably C 10 to C 20 or C 12 to C 18 fatty acid or fatty acid soap (which includes 0.1 to 5% 12-HSA of subparagraph (c) below) wherein 45% to 65%, preferably 50 to 63%, more preferably 55 to 62% of the total fatty acid and fatty acid soap is C 14 myristic acid; b) less than 5% by wt. synthetic surfactant, preferably 1 to 3%; c) 0.1 to 5% by wt., preferably 0.5 to 4% by wt. 12-hydroxystearic acid (12-HSA), wherein the 0.1 to 5% 12-HSA is part of component (a); d) 20 to 50%, preferably 21 to 40% by wt. polyol; e) 0 to 5%, preferably 0.01 to 3%, preferably 0.03 to 2% by wt. cationic polymer; and f) balance water wherein the pH of said liquid cleanser composition is 8.0 to 11.0, preferably 8.5 to 10.0; and wherein the amount (wt%) of myristic acid is calculated according to the following formula: Myristic Acid Total FA + FA soap ∗ 100 = amount wt% of myristic acid . wherein the pH of said liquid cleanser composition is 8.0 to 11.0, preferably 8.5 to 10.0; and wherein the amount (wt%) of myristic acid is calculated according to the following formula: Myristic Acid Total FA + FA soap ∗ 100 = amount wt% of myristic acid .
A combination of a lid retaining structure and a power supply socket , wherein the power supply socket is equipped with a main body portion including a power supply terminal configured to supply electrical power from a battery of a vehicle by insertion of an external terminal through an entrance , and a lid configured to cover the entrance , wherein the lid retaining structure comprises: a handle of the vehicle ; a component supporting section configured to support a component of the vehicle on the handle ; and a stay configured to support the power supply socket on the handle ; wherein the handle comprises a pipe handle supported steerably on a front portion of the vehicle , and a grip disposed on an end of the pipe handle and which is gripped by an occupant of the vehicle ; the component supporting section supports the component on the pipe handle at a location closer to a vehicle body center than the grip ; the stay comprises at least one supported section supported on the pipe handle , a flat section jointly forming a gap between the pipe handle and the flat section and which extends upwardly from the at least one supported section , and a main body supporting section , which is bent from the flat section so as to separate away from the handle , and configured to support the main body portion ; the main body portion is supported on the main body supporting section so that the entrance is located above the main body supporting section ; the lid is connected to the main body portion via a connecting part at a location above the main body supporting section ; and characterised in that the lid , which is detached from the entrance , is retained in a space surrounded by the flat section , the pipe handle , and the component supporting section . a handle of the vehicle ; a component supporting section configured to support a component of the vehicle on the handle ; and a stay configured to support the power supply socket on the handle ; wherein the handle comprises a pipe handle supported steerably on a front portion of the vehicle , and a grip disposed on an end of the pipe handle and which is gripped by an occupant of the vehicle ; the component supporting section supports the component on the pipe handle at a location closer to a vehicle body center than the grip ; the stay comprises at least one supported section supported on the pipe handle , a flat section jointly forming a gap between the pipe handle and the flat section and which extends upwardly from the at least one supported section , and a main body supporting section , which is bent from the flat section so as to separate away from the handle , and configured to support the main body portion ; the main body portion is supported on the main body supporting section so that the entrance is located above the main body supporting section ; the lid is connected to the main body portion via a connecting part at a location above the main body supporting section ; and characterised in that the lid , which is detached from the entrance , is retained in a space surrounded by the flat section , the pipe handle , and the component supporting section .
A pad for applying a coating on a surface, the pad comprising a fabric of relatively higher absorbency material wherein the fabric of the relatively higher absorbency material comprises polyester, microfiber, acrylic, polyamide and/or polypropylene, the fabric having an average thickness T, the pad further comprising filaments of a relatively lower absorbency material wherein the filaments comprises polyester, polyamide and/or polypropylene, the filaments having a length L, wherein the length L of the filaments is equal to or longer than the thickness T, characterised in that the surface area of the pad comprises about 62-80 % filaments , where percentages are calculated based on the number of filaments in relation of the number of threads of the fabric in a specified surface area, and wherein the filaments are essentially evenly distributed in the fabric of the pad .
A method of providing fault tolerance in an Industrial Automation and Control System IACS including a plurality of hosts connected to a communication bus, wherein each host executes cyclically a number of components according to a configuration, comprising - executing an active instance (A1) of a critical component on a first host (H1) and synchronizing a first standby instance (A1') of the critical component instantiated on a second host (H2) with the active instance (A1), - detecting a failure of the first host (H1), - activating a first backup configuration including executing the first standby instance (A1') as the now active instance of the critical component on the second host (H2), and including synchronizing therewith a second standby instance (A1") of the critical component instantiated on a third host (H3). - executing an active instance (A1) of a critical component on a first host (H1) and synchronizing a first standby instance (A1') of the critical component instantiated on a second host (H2) with the active instance (A1), - detecting a failure of the first host (H1), - activating a first backup configuration including executing the first standby instance (A1') as the now active instance of the critical component on the second host (H2), and including synchronizing therewith a second standby instance (A1") of the critical component instantiated on a third host (H3).
A press hardened steel comprising, by weight percent, 0.22-0.25 % carbon, 2.0 to 5.0 % manganese, 0.2-0.3% silicon, 0.2 to 6.0 % chromium, and at least one of 0.1 to 0.6 % molybdenum, 0.01 to 0.1% niobium, and 0.01 to 0.15% vanadium the balance being iron and impurities, wherein the ultimate tensile strength of such steel is at least 1800 MPa and the total elongation is 7 to 8.3%.
A chimeric antigen receptor (CAR) which comprises a CD22-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1 - NYWIH (SEQ ID No. 1); CDR2 - GINPGNNYATYRRKFQG (SEQ ID No. 2) CDR3 - EGYGNYGAWFAY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1 - RSSQSLANSYGNTFLS (SEQ ID No. 4); CDR2 - GISNRFS (SEQ ID No. 5) CDR3 - LQGTHQPYT (SEQ ID No. 6). a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1 - NYWIH (SEQ ID No. 1); CDR2 - GINPGNNYATYRRKFQG (SEQ ID No. 2) CDR3 - EGYGNYGAWFAY (SEQ ID No. 3); and CDR1 - NYWIH (SEQ ID No. 1); CDR2 - GINPGNNYATYRRKFQG (SEQ ID No. 2) CDR3 - EGYGNYGAWFAY (SEQ ID No. 3); and b) a light chain variable region (VL) having CDRs with the following sequences: CDR1 - RSSQSLANSYGNTFLS (SEQ ID No. 4); CDR2 - GISNRFS (SEQ ID No. 5) CDR3 - LQGTHQPYT (SEQ ID No. 6). CDR1 - RSSQSLANSYGNTFLS (SEQ ID No. 4); CDR2 - GISNRFS (SEQ ID No. 5) CDR3 - LQGTHQPYT (SEQ ID No. 6).