mhurhangee/patent-ind-claim-en huggingface dataset:
An isolated conformation-specific antibody or antigen binding fragment thereof which binds specifically to the cis conformation of phosphorylated-Threonine231-tau protein (pT231-tau) for use as a medicament, wherein: (a) said antibody or antigen binding fragment thereof comprises a heavy chain complementarity determining region (CDR-H) CDR-H1 comprising the amino acid sequence of SEQ ID NO: 1, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 2, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 3, and a light chain complementarity determining region (CDR-L) CDR-L1 comprising the amino acid sequence of SEQ ID NO: 4, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 5, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 6; (b) said antibody or antigen binding fragment thereof comprises a heavy chain complementarity determining region (CDR-H) CDR-H1 comprising the amino acid sequence of SEQ ID NO: 7, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 8, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 9, and a light chain complementarity determining region (CDR-L) CDR-L1 comprising the amino acid sequence of SEQ ID NO: 10, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 11, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 12; (c) said antibody or antigen binding fragment thereof comprises a heavy chain protein sequence of SEQ ID NO:22 and a light chain protein sequence of SEQ ID NO:23, or (d) said antibody or antigen binding fragment thereof comprises a heavy chain protein sequence of SEQ ID NO:24 and a light chain protein sequence of SEQ ID NO:25. (a) said antibody or antigen binding fragment thereof comprises a heavy chain complementarity determining region (CDR-H) CDR-H1 comprising the amino acid sequence of SEQ ID NO: 1, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 2, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 3, and a light chain complementarity determining region (CDR-L) CDR-L1 comprising the amino acid sequence of SEQ ID NO: 4, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 5, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 6; (b) said antibody or antigen binding fragment thereof comprises a heavy chain complementarity determining region (CDR-H) CDR-H1 comprising the amino acid sequence of SEQ ID NO: 7, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 8, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 9, and a light chain complementarity determining region (CDR-L) CDR-L1 comprising the amino acid sequence of SEQ ID NO: 10, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 11, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 12; (c) said antibody or antigen binding fragment thereof comprises a heavy chain protein sequence of SEQ ID NO:22 and a light chain protein sequence of SEQ ID NO:23, or (d) said antibody or antigen binding fragment thereof comprises a heavy chain protein sequence of SEQ ID NO:24 and a light chain protein sequence of SEQ ID NO:25.
A formulation for topical application comprising: an active compound, 10 to 60%w/w of a partition coefficient enhancer (PC enhancer), having a structure of the general formula: C n H 2n + 2 O 2 where n represents an integer from 3 to 6 inclusive, a diffusion coefficient enhancer (DC enhancer) selected from the group consisting of a C 12 to C 14 straight chain fatty acid and a C 14 straight chain primary alcohol, a first dimethicone macromer mixture including a dimethicone macromer and a hydrocarbyl methyl siloxane emollient selected from the group consisting of an alkyl methyl siloxane, an aryl methyl siloxane and an alkyl aryl methyl siloxane, and a second dimethicone macromer mixture including a methyl siloxane compound and a cross-linked dimethicone macromer; wherein the formulation comprises less than 10 vol.% water. an active compound, 10 to 60%w/w of a partition coefficient enhancer (PC enhancer), having a structure of the general formula: C n H 2n + 2 O 2 where n represents an integer from 3 to 6 inclusive, a diffusion coefficient enhancer (DC enhancer) selected from the group consisting of a C 12 to C 14 straight chain fatty acid and a C 14 straight chain primary alcohol, a first dimethicone macromer mixture including a dimethicone macromer and a hydrocarbyl methyl siloxane emollient selected from the group consisting of an alkyl methyl siloxane, an aryl methyl siloxane and an alkyl aryl methyl siloxane, and a second dimethicone macromer mixture including a methyl siloxane compound and a cross-linked dimethicone macromer; wherein the formulation comprises less than 10 vol.% water.
An antenna device comprising: a conformal antenna body which has a proper geometry corresponding to a front portion of a platform having a platform nose on which the antenna device is to be mounted, and an antenna unit carried by the antenna body, the 5 antenna unit comprising at least one phased array (A 1 , A 2 , A 3 ) of antenna elements (AE i ), the antenna elements of each of said at least one array being arranged in a spaced-apart relationship in a closed loop path along a circumference of the antenna body having a proper geometry corresponding to a front portion of the platform on which the antenna unit is to be mounted, wherein: 10 each of the antenna elements of said at least one phased array is configured as an elongated end-fire antenna element (AE 1 -AE 8 ) having a boresight substantially parallel to the elongated surface thereof and being capable of emitting linearly polarized radiation, each of the end-fire antenna elements of said at least one phased array 15 extends substantially along a longitudinal axis of the body, and each of the end-fire antenna elements of said at least one phased array is associated with a respective operational module comprising a phase shifting utility (PS), characterized by the entire phased array of the end-fire antenna elements being operable as 20 a forward looking end-fire antenna array producing an antenna beam in a generally forward-looking direction (D) relative to the platform nose, enabling electronic steering of the antenna beam produced by the entire phased array by controllably modifying phases of the antenna elements of the phased array to provide a predetermined phase pattern of a radiating beam emitted by all the 25 antenna elements in the array in accordance with a selected radiation direction around said generally forward-looking direction. 10 each of the antenna elements of said at least one phased array is configured as an elongated end-fire antenna element (AE 1 -AE 8 ) having a boresight substantially parallel to the elongated surface thereof and being capable of emitting linearly polarized radiation, each of the end-fire antenna elements of said at least one phased array 15 extends substantially along a longitudinal axis of the body, and each of the end-fire antenna elements of said at least one phased array is associated with a respective operational module comprising a phase shifting utility (PS), characterized by the entire phased array of the end-fire antenna elements being operable as 20 a forward looking end-fire antenna array producing an antenna beam in a generally forward-looking direction (D) relative to the platform nose, enabling electronic steering of the antenna beam produced by the entire phased array by controllably modifying phases of the antenna elements of the phased array to provide a predetermined phase pattern of a radiating beam emitted by all the 25 antenna elements in the array in accordance with a selected radiation direction around said generally forward-looking direction.
Method for constructing the foundation of a tower structure comprising at least one structure-side connection profile in the form of a pipe segment , the pipe segment being partially filled with a curable casting compound , characterized in that the method comprises the following steps: - providing a plurality of foundation piles selected from a group comprising pipe profiles, T-profiles, I-profiles, Z-profiles or other foundation piles in the form of sheet pile wall segments , - driving a plurality of foundation piles into a load-bearing ground , the method step of driving in being selected from a group comprising vibrating in, ramming in, drilling in or combinations thereof, a plurality of foundation piles being driven into the ground on a circular arc arranged coaxially with respect to the longitudinal axis of the tower structure , and - aligning and fixing the pipe segment coaxially and concentrically with respect to the arrangement of the plurality of foundation piles . - providing a plurality of foundation piles selected from a group comprising pipe profiles, T-profiles, I-profiles, Z-profiles or other foundation piles in the form of sheet pile wall segments , - driving a plurality of foundation piles into a load-bearing ground , the method step of driving in being selected from a group comprising vibrating in, ramming in, drilling in or combinations thereof, a plurality of foundation piles being driven into the ground on a circular arc arranged coaxially with respect to the longitudinal axis of the tower structure , and - aligning and fixing the pipe segment coaxially and concentrically with respect to the arrangement of the plurality of foundation piles .
A movable shingle array of rectangular strip modules fitted with crystalline and thin-film solar cells on optionally different carrier materials, wherein support structures for holding and moving in an extendable or fold-out rail system are arranged under the rectangular strip modules along at least two outer edges , wherein one row or two rows or multiple rows of crystalline and thin-film solar cells arranged next to each other are arranged interconnected in a rectangular strip module , two or more rectangular strip modules overlap each other in the manner of shingles when they are extended, characterized in that contacts are formed on the outside of the short side of each rectangular strip module , the contacts are arranged on the short side directly laterally in or on the rectangular strip module or in the rail system , wherein each rectangular strip module is individually contacted and connected, a defined hole structure consisting of depressions or through openings is arranged along a long side of the rectangular strip module , elevations or pins ), specifically studs or spikes, of a next arranged rectangular strip module engage in the openings of the hole structure, and the rectangular strip modules are coupled to one another via a cable pull or a rail system or via an articulated arm, and the rectangular strip modules are designed to be extendable or retractable and/or erectable and adjustable by means of the cable pull or a rail system or an articulated arm. one row or two rows or multiple rows of crystalline and thin-film solar cells arranged next to each other are arranged interconnected in a rectangular strip module , two or more rectangular strip modules overlap each other in the manner of shingles when they are extended, characterized in that contacts are formed on the outside of the short side of each rectangular strip module , the contacts are arranged on the short side directly laterally in or on the rectangular strip module or in the rail system , wherein each rectangular strip module is individually contacted and connected, a defined hole structure consisting of depressions or through openings is arranged along a long side of the rectangular strip module , elevations or pins ), specifically studs or spikes, of a next arranged rectangular strip module engage in the openings of the hole structure, and the rectangular strip modules are coupled to one another via a cable pull or a rail system or via an articulated arm, and the rectangular strip modules are designed to be extendable or retractable and/or erectable and adjustable by means of the cable pull or a rail system or an articulated arm.
A superconducting magnetizer assembly having an annular opening configured to receive a rotor for magnetizing permanent magnets disposed within the rotor , said assembly comprising: a plurality of coil packs comprising: an inner coil comprising a first superconducting magnet material, the inner coil being configured to generate a first magnetic field in response to an electric current supplied to the inner coil; an outer coil comprising a second superconducting magnet material, the outer coil being disposed about the inner coil and being configured to generate a second magnetic field in response to an electric current supplied to the outer coil ; and a cryostat container, housing the inner and the outer coils and configured to maintain the inner and the outer coils at a set temperature. an inner coil comprising a first superconducting magnet material, the inner coil being configured to generate a first magnetic field in response to an electric current supplied to the inner coil; an outer coil comprising a second superconducting magnet material, the outer coil being disposed about the inner coil and being configured to generate a second magnetic field in response to an electric current supplied to the outer coil ; and a cryostat container, housing the inner and the outer coils and configured to maintain the inner and the outer coils at a set temperature.
A vascular coupling device , comprising - a first and a second coupling element wherein each one of said first and second coupling elements has an external surface (23', 23") facing an external side, a coupling surface (25', 25") facing a coupling side, and a central opening (27', 27"); and - a first and a second tubular connecting element , wherein each one of said first and second tubular elements has a first open end (33', 33") and a second open end , said first open ends (33', 33") being provided with flanges (34', 34"); each one of said first and second tubular connecting elements is arranged in a corresponding central opening (27', 27") of the first and second coupling elements respectively, and with said second open ends protruding through said central openings (27', 27") on said external side of each of said first and second coupling elements ; said first and second coupling elements being removably connected to each other into a locked configuration, or disconnected from each other into an unlocked configuration by means of a first and second locking structure , said first and second locking structures being arranged on a centerline A of the vascular coupling device , and opposite to each other on an outer perimeter of said vascular coupling device , characterized in that said vascular device further comprises a fail-safe arrangement comprising first and second cut-in portions arranged on said first coupling element configured to receive first and second projecting elements arranged on said second coupling element , said first and second cut-in portions and first and second projecting element being arranged on same side of said centerline A, thereby preventing erroneous connection of said first and second coupling elements to each other. - a first and a second coupling element wherein each one of said first and second coupling elements has an external surface (23', 23") facing an external side, a coupling surface (25', 25") facing a coupling side, and a central opening (27', 27"); and - a first and a second tubular connecting element , wherein each one of said first and second tubular elements has a first open end (33', 33") and a second open end , said first open ends (33', 33") being provided with flanges (34', 34"); said first and second coupling elements being removably connected to each other into a locked configuration, or disconnected from each other into an unlocked configuration by means of a first and second locking structure , said first and second locking structures being arranged on a centerline A of the vascular coupling device , and opposite to each other on an outer perimeter of said vascular coupling device , characterized in that said vascular device further comprises a fail-safe arrangement comprising first and second cut-in portions arranged on said first coupling element configured to receive first and second projecting elements arranged on said second coupling element , said first and second cut-in portions and first and second projecting element being arranged on same side of said centerline A, thereby preventing erroneous connection of said first and second coupling elements to each other.
A water-based polymer dispersion, which comprises - a polymer part, and - aggregate particles, which are mixed with the polymer part, characterized in that - the polymer part comprises acrylate polymer which is in the form of particles and has a multimodal particle size distribution, and - the aggregates are formed of the particles of a metal compound, in which case the polymer dispersion also comprises a coagulator of a mixture of the above components, wherein the polymer dispersion comprises, of 100 parts per weight of dispersed material: - 70-90 parts per weight of acrylate polymer, - 5-15 parts per weight of aggregate particles, and - 0.1-5 parts per weight of coagulator which is silicon dioxide, hydrophobic silicon dioxide or a mixture thereof. - a polymer part, and - aggregate particles, which are mixed with the polymer part, characterized in that - the polymer part comprises acrylate polymer which is in the form of particles and has a multimodal particle size distribution, and - the aggregates are formed of the particles of a metal compound, in which case the polymer dispersion also comprises a coagulator of a mixture of the above components, - 70-90 parts per weight of acrylate polymer, - 5-15 parts per weight of aggregate particles, and - 0.1-5 parts per weight of coagulator which is silicon dioxide, hydrophobic silicon dioxide or a mixture thereof.
A non-magnesium process to produce Compacted Graphite Iron comprising by placing a treatment alloy into a treatment ladle, placing an inoculant there over in the treatment ladle and pouring a molten base metal there over, wherein said treatment alloy comprises iron, silicon and lanthanum, wherein the lanthanum is 3 - 30% by weight of the treatment alloy, and silicon is 40 - 50% by weight of the treatment alloy, wherein the treatment alloy optionally comprises at least one of calcium and aluminium in a range of 0.5 - 3% each by weight of the treatment alloy, and the rest of the treatment alloy is Iron, and required additional percentage of said treatment alloy is 0.4 - 2% by weight of composition of said base metal, and said inoculant is 0.1 - 0.5% by weight of the composition, wherein the inoculant optionally is a ferrosilicon composition comprising at least one of calcium, aluminium, barium or lanthanum, or combination thereof.
Studded tyre comprising a tread band , on which there are formed respective pluralities of grooves and blocks , and a plurality of studs which are provided on at least some of said blocks, wherein on at least one of said blocks on which a stud is provided, there is provided a first recess which is intended to receive powdered ice and which is separated from said stud and which extends on said block so as to at least partially surround said stud, and wherein said first recess comprises: - a first portion having a first width, - a second portion having a second width, and - a connection portion which is interposed between said first portion and said second portion and which has a width less than said first width and said second width, wherein there is formed in said block a second recess which is substantially identical to said first recess and which extends so as to partially surround said stud at the opposite side to said first recess , said second recess being arranged in a symmetrical manner relative to said first recess with respect to a circumferential direction which extends through the centre of said stud . - a first portion having a first width, - a second portion having a second width, and - a connection portion which is interposed between said first portion and said second portion and which has a width less than said first width and said second width,
An arrangement for determining an amount of light reaching an image sensor of a video camera , said video camera comprising an imaging lens system guiding a beam path towards the image sensor , wherein the arrangement comprises: an IR-cut filter used during day-mode operation of the video camera , the IR-cut filter being retractably arranged, such that it may be inserted into, and retracted out of, the beam path, a transparent probing element through which the beam path passes on its way to the image sensor , and a light sensor arranged in an end of the transparent probing element , wherein the light sensor is arranged to collect light being scattered or reflected in the transparent probing element , wherein the transparent probing element is retractably arranged, such that it may be inserted into, and retracted out of, the beam path, and the transparent probing element doubles as a dummy glass filter maintaining constant refraction as compared with the IR-cut filter and being used during night-mode operation of the video camera alternate to the IR-cut filter being used during day-mode operation of the video camera , and the transparent probing element is configured to pass both visible and infrared light. an IR-cut filter used during day-mode operation of the video camera , the IR-cut filter being retractably arranged, such that it may be inserted into, and retracted out of, the beam path, a transparent probing element through which the beam path passes on its way to the image sensor , and a light sensor arranged in an end of the transparent probing element , wherein the light sensor is arranged to collect light being scattered or reflected in the transparent probing element , wherein the transparent probing element is retractably arranged, such that it may be inserted into, and retracted out of, the beam path, and the transparent probing element doubles as a dummy glass filter maintaining constant refraction as compared with the IR-cut filter and being used during night-mode operation of the video camera alternate to the IR-cut filter being used during day-mode operation of the video camera , and the transparent probing element is configured to pass both visible and infrared light.