mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody having the following properties: specifically binding to Glycoprotein-A Repetitions Predominant (GARP); having an inhibitory activity to the immunosuppressive function of regulatory T cells; having antibody-dependent cellular cytotoxic (ADCC) activity; and having in vivo antitumor activity, which has: (a) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 136 shown in SEQ ID NO: 33, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 37; (b) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 136 shown in SEQ ID NO: 35, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 39; or (c) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 139 shown in SEQ ID NO: 41, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 43. specifically binding to Glycoprotein-A Repetitions Predominant (GARP); having an inhibitory activity to the immunosuppressive function of regulatory T cells; having antibody-dependent cellular cytotoxic (ADCC) activity; and having in vivo antitumor activity, (a) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 136 shown in SEQ ID NO: 33, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 37; (b) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 136 shown in SEQ ID NO: 35, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 39; or (c) a heavy chain variable region consisting of the amino acid sequence at amino acid positions 20 to 139 shown in SEQ ID NO: 41, and a light chain variable region consisting of the amino acid sequence at amino acid positions 21 to 129 shown in SEQ ID NO: 43.
A single-domain antibody, wherein the antibody is an immunoglobulin VH domain comprising modifications H35D, A78V, S93G/V, and W103R relative to a human germline VH domain or a VH domain family consensus sequence, with the position numbering being according to the Kabat numbering scheme.
Regulating flap reduction gear for an electrically driven regulating flap for regulating a gas or liquid volume flow, in particular in the field of heating, ventilation, air conditioning, fire protection or smoke protection, comprising two parallel bearing plates between which gear parts are rotatably arranged, and a plurality of spacers which keep the two bearing plates at a distance from one another, wherein the plurality of spacers are designed as tabs (7a-7e) of one, first bearing plate , which are bent by 90° from the plane of the first bearing plate and comprise at least one lateral projection , and the tabs (7a-7e) are inserted with their free tab ends into plug-in openings of the other second bearing plate until their at least one lateral projection rests against the second bearing plate , characterized in that one of the rotary gear parts can be pivoted between two end positions and rests against one of the tabs in at least one of its two end positions, the first bearing plate comprises a bearing opening for the pivotable gear part and is reinforced around the bearing opening in the region of that or those tab(s) against which the pivotable gear part rests in its end positions, and the first bearing plate is reinforced in the region of that or those tab(s) against which the pivotable gear part rests, by a bulge that radially inwardly projects into the bearing opening .
A method comprising: a) providing initial starting genetic material comprising cell free polynucleotides; b) converting polynucleotides from the initial starting genetic material into tagged parent polynucleotides by ligating non-unique barcodes to the cell free polynucleotides such that the combination of the barcode and the sequence of the cell free polynucleotide creates a unique sequence that may be individually tracked; c) amplifying the tagged parent polynucleotides to produce amplified progeny polynucleotides; d) sequencing a subset of the amplified progeny polynucleotides to produce sequence reads; e) grouping the sequence reads into families, each family generated from a unique tagged parent polynucleotide from step (b); and f) producing a representation of information in the tagged parent polynucleotides and/or initial starting genetic material with reduced noise and/or distortion compared with sequence reads within a family. a) providing initial starting genetic material comprising cell free polynucleotides; b) converting polynucleotides from the initial starting genetic material into tagged parent polynucleotides by ligating non-unique barcodes to the cell free polynucleotides such that the combination of the barcode and the sequence of the cell free polynucleotide creates a unique sequence that may be individually tracked; c) amplifying the tagged parent polynucleotides to produce amplified progeny polynucleotides; d) sequencing a subset of the amplified progeny polynucleotides to produce sequence reads; e) grouping the sequence reads into families, each family generated from a unique tagged parent polynucleotide from step (b); and f) producing a representation of information in the tagged parent polynucleotides and/or initial starting genetic material with reduced noise and/or distortion compared with sequence reads within a family.
A surgical system comprising: a patient-side apparatus including: a first manipulator that supports a first surgical instrument ; a second manipulator that supports a second surgical instrument ; a third manipulator that supports a third surgical instrument ; and a fourth manipulator that supports an endoscope ; a remote-control apparatus for operation of the first to fourth manipulators, and including a display device configured to display an image captured by the endoscope; and a control apparatus configured and arranged to display, on the display device , a graphical user interface overlapped with the image captured by the endoscope , characterized in that the graphical user interface including a first area that indicates information on the first surgical instrument , a second area that indicates information on the third surgical instrument , a third area that indicates information on the second surgical instrument , which are arranged in one of an upper end portion and a lower end portion in a display area of the display device and further including, at a position different from that of the one of the upper end portion and the lower end portion in the display area, a surgical instrument position display area that indicates positional relationships of the first, second, third surgical instruments with respect to a field of view of the endoscope . a patient-side apparatus including: a first manipulator that supports a first surgical instrument ; a second manipulator that supports a second surgical instrument ; a third manipulator that supports a third surgical instrument ; and a fourth manipulator that supports an endoscope ; a first manipulator that supports a first surgical instrument ; a second manipulator that supports a second surgical instrument ; a third manipulator that supports a third surgical instrument ; and a fourth manipulator that supports an endoscope ; a remote-control apparatus for operation of the first to fourth manipulators, and including a display device configured to display an image captured by the endoscope; and a control apparatus configured and arranged to display, on the display device , a graphical user interface overlapped with the image captured by the endoscope , characterized in that the graphical user interface including a first area that indicates information on the first surgical instrument , a second area that indicates information on the third surgical instrument , a third area that indicates information on the second surgical instrument , which are arranged in one of an upper end portion and a lower end portion in a display area of the display device and further including, at a position different from that of the one of the upper end portion and the lower end portion in the display area, a surgical instrument position display area that indicates positional relationships of the first, second, third surgical instruments with respect to a field of view of the endoscope .
A composition comprising: a platelet cell; a chemical linker moiety; and a therapeutic agent; wherein the therapeutic agent is covalently linked to the platelet cell through the chemical linker moiety; and wherein the therapeutic agent is an immunotherapeutic agent, wherein the immunotherapeutic agent is selected from an anti-PDLl antibody, an anti-PDl antibody, an anti-CTLA4 antibody, an anti-CD47 antibody, or a combination thereof. a platelet cell; a chemical linker moiety; and a therapeutic agent; wherein the therapeutic agent is covalently linked to the platelet cell through the chemical linker moiety; and wherein the therapeutic agent is an immunotherapeutic agent, wherein the immunotherapeutic agent is selected from an anti-PDLl antibody, an anti-PDl antibody, an anti-CTLA4 antibody, an anti-CD47 antibody, or a combination thereof.
A method for inspecting archive slices for malware, the method comprising: mounting, to a disk, a first slice of a plurality of slices in a backup archive, wherein the first slice is an image of user data at a first time; detecting a modified block of the mounted first slice by comparing blocks of the mounted first slice to blocks of a second slice of the plurality of slices, wherein the second slice is an image of the user data captured before the first time; identifying, on a file system of the disk, at least one file in the mounted first slice that corresponds to the detected modified block; scanning the at least one file for viruses and/or malicious software; and in response to detecting that the at least one file is infected with a virus and/or malicious software, generating a cured slice characterised in : generating a copy of the second slice; and transferring, to the copy of the second slice, all files corresponding to a plurality of modified blocks in the mounted first slice and not including the at least one file, wherein the copy of the second slice is the cured slice. mounting, to a disk, a first slice of a plurality of slices in a backup archive, wherein the first slice is an image of user data at a first time; detecting a modified block of the mounted first slice by comparing blocks of the mounted first slice to blocks of a second slice of the plurality of slices, wherein the second slice is an image of the user data captured before the first time; identifying, on a file system of the disk, at least one file in the mounted first slice that corresponds to the detected modified block; scanning the at least one file for viruses and/or malicious software; and in response to detecting that the at least one file is infected with a virus and/or malicious software, generating a cured slice characterised in : generating a copy of the second slice; and transferring, to the copy of the second slice, all files corresponding to a plurality of modified blocks in the mounted first slice and not including the at least one file, wherein the copy of the second slice is the cured slice. generating a copy of the second slice; and transferring, to the copy of the second slice, all files corresponding to a plurality of modified blocks in the mounted first slice and not including the at least one file, wherein the copy of the second slice is the cured slice.
A method for manufacturing a surface emitting laser made of a group-III nitride semiconductor by an MOVPE method, comprising: (a) a step of growing a first cladding layer of a first conductive type on a substrate ; (b) a step of growing a first optical guide layer of said first conductive type on said first cladding layer ; (c) a step of forming holes by etching, each hole having an opening at an upper surface of said first optical guide layer and extending from the upper surface of said first optical guide layer to the inside thereof, said holes having a two-dimensional periodicity in a plane parallel to said first optical guide layer ; (d) a step of supplying a gas containing a group-III material and a nitrogen source and performing growth to close the openings of said holes thereby forming cavities within said first optical guide layer and pyramidal recessed portions above said cavities , wherein said recessed portions are having at least one facet of a predetermined plane direction; and (e) a step of planarizing the upper surface of said first optical guide layer by mass transport, after said step (d) has been performed, whereby a photonic crystal layer is formed within said first optical guide layer . (a) a step of growing a first cladding layer of a first conductive type on a substrate ; (b) a step of growing a first optical guide layer of said first conductive type on said first cladding layer ; (c) a step of forming holes by etching, each hole having an opening at an upper surface of said first optical guide layer and extending from the upper surface of said first optical guide layer to the inside thereof, said holes having a two-dimensional periodicity in a plane parallel to said first optical guide layer ; (d) a step of supplying a gas containing a group-III material and a nitrogen source and performing growth to close the openings of said holes thereby forming cavities within said first optical guide layer and pyramidal recessed portions above said cavities , wherein said recessed portions are having at least one facet of a predetermined plane direction; and (e) a step of planarizing the upper surface of said first optical guide layer by mass transport, after said step (d) has been performed, whereby a photonic crystal layer is formed within said first optical guide layer .
A method for managing beamformed uplink transmissions from one or more beamformer devices , wherein the method is initialized by a beamformee device , the method comprising: transmitting , by a beamformee device , to one or more beamformer devices , an indication of a precoder for uplink transmission per uplink transmission ; transmitting , by the beamformee device , a trigger frame to the one or more beamformer devices, wherein the trigger frame comprises the indication of the precoder; before transmitting the trigger frame, transmitting, by the beamformee device , a channel sounding announcement, for prompting the beamformer devices initiating a channel sounding procedure, and to receive a corresponding channel sounding frame from the beamformer devices responsive to the channel sounding announcement ; transmitting, by the beamformee device , a feedback frame to a respective channel sounding frame , and transmitting, by the beamformee device , two or more different feedback update frames for updating a beamformer device with new precoding information to the same beamformer device based on the same channel sounding frame . transmitting , by a beamformee device , to one or more beamformer devices , an indication of a precoder for uplink transmission per uplink transmission ; transmitting , by the beamformee device , a trigger frame to the one or more beamformer devices, wherein the trigger frame comprises the indication of the precoder; before transmitting the trigger frame, transmitting, by the beamformee device , a channel sounding announcement, for prompting the beamformer devices initiating a channel sounding procedure, and to receive a corresponding channel sounding frame from the beamformer devices responsive to the channel sounding announcement ; transmitting, by the beamformee device , a feedback frame to a respective channel sounding frame , and transmitting, by the beamformee device , two or more different feedback update frames for updating a beamformer device with new precoding information to the same beamformer device based on the same channel sounding frame .
Measuring arrangement with - at least two measurement inputs (22a-c) for the capture of signals of alternating electrical magnitudes; - a sampling apparatus that is arranged following the measurement inputs (22a-c) with which a sampling of the signals is performed while forming digital sample values; and - a clock tracking apparatus that performs an adaptation of a sampling clock used by the sampling apparatus for the sampling in the light of the frequency of the signal to be sampled; wherein - the sampling apparatus is configured to sample at least two of the signals, each with its own sampling clock, wherein the clock tracking apparatus is configured to perform an adaptation of the sampling clock in the light of the frequency of the signal to be sampled simultaneously for each of these at least two signals, wherein - the measuring arrangement is part of a device for the observation, monitoring and/or protection of an electrical energy supply network; characterized in that - the measurement inputs (22a-c) are divided into different tracking groups, wherein respective measurement inputs (22a-c) of such signals whose frequencies, as a result of the particular features of the energy supply network, match are grouped into the same tracking group; and - the clock tracking apparatus is configured to perform an adaptation of the sampling clock for each tracking group. - at least two measurement inputs (22a-c) for the capture of signals of alternating electrical magnitudes; - a sampling apparatus that is arranged following the measurement inputs (22a-c) with which a sampling of the signals is performed while forming digital sample values; and - a clock tracking apparatus that performs an adaptation of a sampling clock used by the sampling apparatus for the sampling in the light of the frequency of the signal to be sampled; wherein - the sampling apparatus is configured to sample at least two of the signals, each with its own sampling clock, wherein the clock tracking apparatus is configured to perform an adaptation of the sampling clock in the light of the frequency of the signal to be sampled simultaneously for each of these at least two signals, wherein - the measuring arrangement is part of a device for the observation, monitoring and/or protection of an electrical energy supply network; characterized in that - the measurement inputs (22a-c) are divided into different tracking groups, wherein respective measurement inputs (22a-c) of such signals whose frequencies, as a result of the particular features of the energy supply network, match are grouped into the same tracking group; and - the clock tracking apparatus is configured to perform an adaptation of the sampling clock for each tracking group.
A touch panel comprising a sheet-like first pyroelectric material and a sheet-like second pyroelectric materials- , and capable of detecting press pressure applied to the first pyroelectric material and/or second pyroelectric material ; wherein an upper surface of the first pyroelectric material and an upper surface of the second pyroelectric material are surfaces on which a first polar charge is generated when the temperature increases, and a second polar charge opposite to the first polar charge is generated when the temperature decreases; a lower surface of the first pyroelectric material and a lower surface of the second pyroelectric material are surfaces on which the second polar charge is generated when the temperature increases, and the first polar charge is generated when the temperature decreases; an electrode (Ec1) disposed on the upper surface of the first pyroelectric material and an electrode (Ec2) disposed on the lower surface of the second pyroelectric material are electrically connected to each other; an electrode (Ed1) disposed on the lower surface of the first pyroelectric material and an electrode (Ed2) disposed on the upper surface of the second pyroelectric material are electrically connected to each other; the first pyroelectric material and the second pyroelectric material are laminated so that the lower surface of the first pyroelectric material and the upper surface of the second pyroelectric material are laminated via an intermediate conductive layer ; and when a touch operation is performed on the touch panel, compressive force acts on the first pyroelectric material and a tensile force acts on the second pyroelectric material .
A racket comprising a grommet , a frame , and a string , wherein the grommet includes: a base ; and a pipe that rises from the base and through which the string is passed, and the frame includes: a grommet groove in which the base is accommodated; and a small groove recessed from the grommet groove characterized in that the base is spaced apart from a bottom of the small groove . the grommet includes: a base ; and a pipe that rises from the base and through which the string is passed, and a base ; and a pipe that rises from the base and through which the string is passed, and the frame includes: a grommet groove in which the base is accommodated; and a small groove recessed from the grommet groove characterized in that a grommet groove in which the base is accommodated; and a small groove recessed from the grommet groove characterized in that the base is spaced apart from a bottom of the small groove .
A box for a battery pack, comprising a base plate and a frame , the base plate being connected with the frame ; wherein the base plate comprises: a first plate ; a second plate , disposed opposite and spaced to the first plate ; and a perforated plate , provided with a plurality of holes ; wherein the perforated plate is located between the first plate and the second plate , and is welded and fixed to the first plate and the second plate respectively; wherein the base plate comprises a reinforcing crossbeam , and a height of the reinforcing crossbeam is the same as a height of the perforated plate ; the reinforcing crossbeam is located between the first plate and the second plate , and connecting the first plate and the second plate to each other; and the perforated plate and the reinforcing crossbeam are arranged at different positions of the first plate . a first plate ; a second plate , disposed opposite and spaced to the first plate ; and a perforated plate , provided with a plurality of holes ; wherein the perforated plate is located between the first plate and the second plate , and is welded and fixed to the first plate and the second plate respectively; wherein the base plate comprises a reinforcing crossbeam , and a height of the reinforcing crossbeam is the same as a height of the perforated plate ; the reinforcing crossbeam is located between the first plate and the second plate , and connecting the first plate and the second plate to each other; and the perforated plate and the reinforcing crossbeam are arranged at different positions of the first plate .