mhurhangee/patent-ind-claim-en huggingface dataset:
A process for synthesis of crystalline mesotrione, said process comprising following steps: i. reacting 4-toluenesulfonyl chloride with at least one alkali metal sulphite and at least one alkali metal bicarbonate, to obtain alkali metal toluene-4-sulfinate, followed by reacting said alkali metal toluene-4-sulfinate with at least one alkali metal salt of monochloroacetic acid to obtain 4-methylsulfonyl toluene; ii. nitrating 4-methylsulfonyl toluene using sulphuric acid followed by a mixed acid comprising nitric acid and oleum to obtain 2-nitro-4-methylsulfonyl toluene; iii. oxidizing 2-nitro-4-methylsulfonyl toluene using at least one oxidizing agent in the presence of at least one first catalyst to obtain 2-nitro-4-methylsulfonylbenzoic acid; iv. halogenating 2-nitro-4-methylsulfonylbenzoic acid using at least one halogenating agent in a first fluid medium to obtain 2-nitro-4-methylsulfonylbenzoyl halide; v. reacting 2-nitro-4-methylsulfonylbenzoyl halide with aqueous solution of alkali metal salt of 1,3-cyclohexanedione at a temperature in the range of 0 °C to 15 °C in the presence of a second fluid medium, and at least one second catalyst to obtain 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohex-2-en-1-one; vi. reacting 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohex-2-en-1-one with at least one base, a third fluid medium and at least one cyanide ion source to obtain an amorphous mesotrione having purity less than or equal to 99 %; and vii. converting said amorphous mesotrione to said crystalline mesotrione having purity greater than 99 %. i. reacting 4-toluenesulfonyl chloride with at least one alkali metal sulphite and at least one alkali metal bicarbonate, to obtain alkali metal toluene-4-sulfinate, followed by reacting said alkali metal toluene-4-sulfinate with at least one alkali metal salt of monochloroacetic acid to obtain 4-methylsulfonyl toluene; ii. nitrating 4-methylsulfonyl toluene using sulphuric acid followed by a mixed acid comprising nitric acid and oleum to obtain 2-nitro-4-methylsulfonyl toluene; iii. oxidizing 2-nitro-4-methylsulfonyl toluene using at least one oxidizing agent in the presence of at least one first catalyst to obtain 2-nitro-4-methylsulfonylbenzoic acid; iv. halogenating 2-nitro-4-methylsulfonylbenzoic acid using at least one halogenating agent in a first fluid medium to obtain 2-nitro-4-methylsulfonylbenzoyl halide; v. reacting 2-nitro-4-methylsulfonylbenzoyl halide with aqueous solution of alkali metal salt of 1,3-cyclohexanedione at a temperature in the range of 0 °C to 15 °C in the presence of a second fluid medium, and at least one second catalyst to obtain 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohex-2-en-1-one; vi. reacting 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohex-2-en-1-one with at least one base, a third fluid medium and at least one cyanide ion source to obtain an amorphous mesotrione having purity less than or equal to 99 %; and vii. converting said amorphous mesotrione to said crystalline mesotrione having purity greater than 99 %.
A method of generating a methylation profile of a biomarker in a subject suspected of having a solid tumor, wherein the biomarker is cg10673833, wherein the methylation profile comprises a methylation rate at cg10673833, wherein the methylation rate is the proportion of sequence reads showing methylation at cg10673833 divided by the total number of reads covering cg10673833, and wherein the solid tumor is esophagus cancer, pancreatic cancer, or stomach cancer, the method comprising: (a) processing an extracted genomic DNA with a deaminating agent to generate a genomic DNA sample comprising deaminated nucleotides, wherein the extracted genomic DNA is obtained from a biological sample from the subj ect; (b) detecting a hybridization between the extracted genomic DNA and a probe, or a product thereof, wherein the probe hybridizes to the biomarker cg10673833; and (c) generating the methylation profile based on the detected hybridization between the extracted genomic DNA and the probe, or the product thereof. wherein the biomarker is cg10673833, wherein the methylation profile comprises a methylation rate at cg10673833, wherein the methylation rate is the proportion of sequence reads showing methylation at cg10673833 divided by the total number of reads covering cg10673833, and wherein the solid tumor is esophagus cancer, pancreatic cancer, or stomach cancer, (a) processing an extracted genomic DNA with a deaminating agent to generate a genomic DNA sample comprising deaminated nucleotides, wherein the extracted genomic DNA is obtained from a biological sample from the subj ect; (b) detecting a hybridization between the extracted genomic DNA and a probe, or a product thereof, wherein the probe hybridizes to the biomarker cg10673833; and (c) generating the methylation profile based on the detected hybridization between the extracted genomic DNA and the probe, or the product thereof.
A system for aiding an operator in the backing up of a trailer by a towing vehicle, the trailer and the vehicle being coupled together by a jointed connection where the jointed connection has a plurality of connection angles and where each connection angle has a corresponding turning radius for the trailer, the vehicle having a plurality of steering positions where each steering position has a corresponding turning radius of the vehicle, comprising: a first measuring device for determining the connection angle, a second measuring device for determining the steering position, one or more calculating devices that compute a first value that represents the turning radius of the trailer or its equivalent by using data from the first measuring device and a second value that represents the turning radius of the vehicle or its equivalent by using data from the second measuring device, and a one or more output devices to indicate to an operator one or more of (i) the first value and the second value, and (ii) a difference between the first value and the second value, wherein the one or more output devices further comprise an alerting mechanism that emits an alert that is (i) received by an operator of the system without requiring the operator to look directly at the alerting device, characterized in that the alerting mechanism emits an alert that (ii) is either a general indication of the connection angle becoming zero or crossing through zero, a general indication of the difference between the turning radii of the vehicle and trailer becoming zero or crossing through zero, or both. a first measuring device for determining the connection angle, a second measuring device for determining the steering position, one or more calculating devices that compute a first value that represents the turning radius of the trailer or its equivalent by using data from the first measuring device and a second value that represents the turning radius of the vehicle or its equivalent by using data from the second measuring device, and a one or more output devices to indicate to an operator one or more of (i) the first value and the second value, and (ii) a difference between the first value and the second value, wherein the one or more output devices further comprise an alerting mechanism that emits an alert that is (i) received by an operator of the system without requiring the operator to look directly at the alerting device, characterized in that the alerting mechanism emits an alert that (ii) is either a general indication of the connection angle becoming zero or crossing through zero, a general indication of the difference between the turning radii of the vehicle and trailer becoming zero or crossing through zero, or both.
Timepiece escapement mechanism , arranged to cooperate with means for providing torque , and comprising at least one escape wheel , which is subjected to a rotational torque, whose moment is lower than or equal to a nominal moment, about a first pivot axis (D1), under the action of said means for providing torque , and comprising a regulating member integral with a regulating wheel set mounted to pivot about a second pivot axis (D2), wherein said escapement mechanism constitutes a magnetic cylinder escapement, and said escape wheel comprises a plurality of actuators , regularly spaced around the periphery of a first disc , pivoting integrally with said escape wheel , said actuators each comprising magnetically charged or ferromagnetic magnetic field conductor parts, characterised in that each of said actuators is arranged to work in attraction, via said first disc , with at least a second disc comprised in said regulating wheel set and pivoting integrally therewith, said second disc being soft ferromagnetic and not magnetically charged, each said actuator including at least a first magnetic impulse part , and a second magnetic stop part , which generate or guide magnetic fields of substantially the same direction and the same sense, substantially parallel to said first pivot axis (D1) of said escape wheel , characterised in that said escape mechanism comprises, substantially in the same plane as said second disc , a conductive ferromagnetic plate , disposed underneath said disc and not in contact therewith, said plate comprising a cutout which surrounds, in a contactless manner, the periphery of said second disc , so as to provide a variable air-gap (E) between said plate and said second disc , and said plate being arranged to ensure the closing of the magnetic circuit formed by at least one said actuator , said first disc , said second disc , and a structure in which said escape wheel pivots and which carries said plate , and characterised in that said second disc comprises a first peripheral area defining with said plate a first air-gap (E1) greater than a second air-gap (E2) that exists between said plate and a second peripheral area adjacent to said first area , and in that said actuators and said first air-gap (E1) and said second air-gap (E2) are dimensioned such that a said first magnetic part can only cross said second air-gap (E2) and is blocked by said first air-gap (E1).
A system , comprising: an interface , which is configured to receive, for at least a region of an anatomical map of at least a portion of a heart , positions and respective electrophysiological (EP) wave propagation velocity vectors , the vectors having respective magnitudes; and a processor , which is configured to: scale the magnitudes; and present scaled vectors, having the scaled magnitudes, overlaid on the anatomical map ; and characterized in that the processor is configured to nonlinearly scale the magnitudes by: dividing a range of the magnitudes into a low-magnitude region, a high-magnitude region, and an intermediate-magnitude region between the low-magnitude region and the high-magnitude region; and emphasizing magnitude differences within the intermediate-magnitude region relative to the low-magnitude region and the high-magnitude region. an interface , which is configured to receive, for at least a region of an anatomical map of at least a portion of a heart , positions and respective electrophysiological (EP) wave propagation velocity vectors , the vectors having respective magnitudes; and a processor , which is configured to: scale the magnitudes; and present scaled vectors, having the scaled magnitudes, overlaid on the anatomical map ; and characterized in that the processor is configured to nonlinearly scale the magnitudes by: scale the magnitudes; and present scaled vectors, having the scaled magnitudes, overlaid on the anatomical map ; and characterized in that the processor is configured to nonlinearly scale the magnitudes by: dividing a range of the magnitudes into a low-magnitude region, a high-magnitude region, and an intermediate-magnitude region between the low-magnitude region and the high-magnitude region; and emphasizing magnitude differences within the intermediate-magnitude region relative to the low-magnitude region and the high-magnitude region.
A cable actuated lift device , comprising: a cable having a predetermined length; a first end of the predetermined length of cable provided in force transmitting communication with a linear actuator; a second end of the predetermined length of cable provided in force transmitting communication with a surface cleaning device; the linear actuator comprising an extended and retracted position, and adapted to extend and retract the predetermined length of cable , wherein the extended position of the linear actuator corresponds to the surface cleaning device being provided in contact with a surface and the retracted position corresponds to the surface cleaning device being provided in a raised position with respect to the surface; the predetermined length of cable extending in a first direction and a second direction, wherein the cable is provided in contact with a pulley at a transition point between the first direction and the second direction; characterized in that the pulley being rotatable about a first axis and pivotable about a second axis, the second axis comprising a substantially horizontal axis; and wherein pivoting of the pulley about the second axis permits translation of the surface cleaning device at least when the surface cleaning device is provided in contact with a surface. a cable having a predetermined length; a first end of the predetermined length of cable provided in force transmitting communication with a linear actuator; a second end of the predetermined length of cable provided in force transmitting communication with a surface cleaning device; the linear actuator comprising an extended and retracted position, and adapted to extend and retract the predetermined length of cable , wherein the extended position of the linear actuator corresponds to the surface cleaning device being provided in contact with a surface and the retracted position corresponds to the surface cleaning device being provided in a raised position with respect to the surface; the predetermined length of cable extending in a first direction and a second direction, wherein the cable is provided in contact with a pulley at a transition point between the first direction and the second direction; characterized in that the pulley being rotatable about a first axis and pivotable about a second axis, the second axis comprising a substantially horizontal axis; and wherein pivoting of the pulley about the second axis permits translation of the surface cleaning device at least when the surface cleaning device is provided in contact with a surface.
A dispenser for dispensing a hygiene product, comprising: a time-of-flight sensor (TF) for measuring a position of an object relative to the dispenser ; and a controller configured (CT) to selectively operate at least one function of the dispenser based on the measured position of the object relative to the dispenser , characterised in that the time-of-flight sensor (TF) is configured to operate at a first sample rate when the measured position is in a first zone (Z1) and at a second sample rate when the measured position is in a second zone (Z2), the first sample rate being higher than the second sample rate, the controller (CT) is configured to operate a first function of the at least one function when the measured position is in the first zone (Z1), and wherein the controller (CT) is configured to operate a second function of the at least one function when the measured position is in the second zone (Z2), and the second function is a power-up function or a display function. a time-of-flight sensor (TF) for measuring a position of an object relative to the dispenser ; and a controller configured (CT) to selectively operate at least one function of the dispenser based on the measured position of the object relative to the dispenser , characterised in that the time-of-flight sensor (TF) is configured to operate at a first sample rate when the measured position is in a first zone (Z1) and at a second sample rate when the measured position is in a second zone (Z2), the first sample rate being higher than the second sample rate, the controller (CT) is configured to operate a first function of the at least one function when the measured position is in the first zone (Z1), and wherein the controller (CT) is configured to operate a second function of the at least one function when the measured position is in the second zone (Z2), and the second function is a power-up function or a display function.
A car audio output control device , comprising: a storage unit that stores an identification code for each output mode with respect to a plurality of output modes; an interface unit that receives a device acoustic source and an identification code defining an attribute of the device acoustic source from a peripheral device when an acoustic source generated from the peripheral device is detected; and a control unit that controls an output of a car audio such that when a device acoustic source and an identification code are received through the interface unit while a source acoustic source self-generated from the car audio is outputted, the control unit selects one output mode matched with the received identification code from among the plurality of output modes, and controls according to the selected output mode: an acoustic source path from the source acoustic source of the car audio to a car audio output unit; and an acoustic source path from the device acoustic source of the peripheral device to the car audio output unit, so as to output an acoustic source corresponding to a change in the acoustic source paths, wherein the acoustic source paths and acoustic source states of the output of the car audio are controlled so as to be different with respect to each of the plurality of output modes. a storage unit that stores an identification code for each output mode with respect to a plurality of output modes; an interface unit that receives a device acoustic source and an identification code defining an attribute of the device acoustic source from a peripheral device when an acoustic source generated from the peripheral device is detected; and a control unit that controls an output of a car audio such that when a device acoustic source and an identification code are received through the interface unit while a source acoustic source self-generated from the car audio is outputted, the control unit selects one output mode matched with the received identification code from among the plurality of output modes, and controls according to the selected output mode: an acoustic source path from the source acoustic source of the car audio to a car audio output unit; and an acoustic source path from the device acoustic source of the peripheral device to the car audio output unit, so as to output an acoustic source corresponding to a change in the acoustic source paths, an acoustic source path from the source acoustic source of the car audio to a car audio output unit; and an acoustic source path from the device acoustic source of the peripheral device to the car audio output unit, so as to output an acoustic source corresponding to a change in the acoustic source paths, wherein the acoustic source paths and acoustic source states of the output of the car audio are controlled so as to be different with respect to each of the plurality of output modes.
An anchoring assembly for the anchoring of a dental prosthesis, said anchoring assembly comprising: i) a plurality of dental implants , each dental implant comprising a threaded portion and an abutment comprising a threaded hole ; ii) a plurality of pins every one of which is configured to be mounted on one of said abutments and comprises a through axial cavity ; iii) a plurality of blocks , each block comprising a through hole configured to receive a respective pin ; iv) a plurality of telescopic arms , wherein said telescopic arms and said blocks comprise coupling means having a complementary shape and configured to define a spherical coupling, wherein said pins comprise an external thread , characterized in that said through holes of the blocks have an internal thread corresponding to said external thread , wherein the free end of each abutment has a frustoconical shape and each pin comprises a matching end portion having a frustoconical shape. i) a plurality of dental implants , each dental implant comprising a threaded portion and an abutment comprising a threaded hole ; ii) a plurality of pins every one of which is configured to be mounted on one of said abutments and comprises a through axial cavity ; iii) a plurality of blocks , each block comprising a through hole configured to receive a respective pin ; iv) a plurality of telescopic arms ,
Operating method for a fuel cell with - a number of electrode membrane units , - a number of bipolar plates , wherein - each bipolar plate is arranged between two adjacent electrode-membrane-units , - viewed along a stacking direction of the electrode membrane units cross-sectionally along the stacking direction, the bipolar plates in a projection area project to differing degrees beyond the electrode membrane units , - the protrusion area is designed so that cooling gas , which is air, circulates around it so that the protrusion area of the bipolar plates is air-cooled, - the fuel cell is installed in a train , - a maximal power of the fuel cell amounts to at least 100 kW, and - a cooling gas supply exists from a surrounding area of the train toward the fuel cell , which is an air duct, so that the fuel cell is cooled by an airflow. - a number of electrode membrane units , - a number of bipolar plates , - each bipolar plate is arranged between two adjacent electrode-membrane-units , - viewed along a stacking direction of the electrode membrane units cross-sectionally along the stacking direction, the bipolar plates in a projection area project to differing degrees beyond the electrode membrane units , - the protrusion area is designed so that cooling gas , which is air, circulates around it so that the protrusion area of the bipolar plates is air-cooled, - the fuel cell is installed in a train , - a maximal power of the fuel cell amounts to at least 100 kW, and - a cooling gas supply exists from a surrounding area of the train toward the fuel cell , which is an air duct, so that the fuel cell is cooled by an airflow.
A two-component polyurethane composition consisting of a polyol component K1 and a polyisocyanate component K2 ; wherein the polyol component K1 comprises - at least one polyester polyol A1 based on dimer fatty acids and/or dimer fatty alcohols having an OH number of 65-350 mg KOH/g; and - at least one polybutadiene polyol having an OH functionality in the range of 2.1-2.9, especially 2.3-2.7, and an OH number of 40-100 mg KOH/g A2 ; and - at least one alkoxylated alkylenediamine having an OH number of 350-950 mg KOH/g A3 ; and wherein the polyisocyanate component K2 comprises at least one aromatic polyisocyanate B1, where the ratio of the OH groups of A1/A2 is 1-20. wherein the polyol component K1 comprises - at least one polyester polyol A1 based on dimer fatty acids and/or dimer fatty alcohols having an OH number of 65-350 mg KOH/g; and - at least one polybutadiene polyol having an OH functionality in the range of 2.1-2.9, especially 2.3-2.7, and an OH number of 40-100 mg KOH/g A2 ; and - at least one alkoxylated alkylenediamine having an OH number of 350-950 mg KOH/g A3 ; - at least one polyester polyol A1 based on dimer fatty acids and/or dimer fatty alcohols having an OH number of 65-350 mg KOH/g; and - at least one polybutadiene polyol having an OH functionality in the range of 2.1-2.9, especially 2.3-2.7, and an OH number of 40-100 mg KOH/g A2 ; and - at least one alkoxylated alkylenediamine having an OH number of 350-950 mg KOH/g A3 ; and wherein the polyisocyanate component K2 comprises at least one aromatic polyisocyanate B1, where the ratio of the OH groups of A1/A2 is 1-20.
A pharmaceutical composition comprising ( S )-(3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl)methanol or a salt thereof for use in a method of treating optic neuropathy in a mammal.