A compound having the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A is O; B is selected from one of the following groups: Q is O; V is H, halo or -N(R 12 ) 2 ; W is N, CH or CF; R 1 is -(CH 2 ) m -C(O)OR 13 ; R 2 is methyl; R 3 is selected from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl and -N(R 12 ) 2 ; R 4 , R 5 , R 7 and R 8 are each independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, halo, -OR 14 , -SR 14 and -N(R 14 ) 2 ; R 6 , R 9 , R 10 and R 11 are each independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 9- or 10-membered bicyclic heteroaryl, halo, -OR 14 , -SR 14 , -S(O)R 14 , -S(O) 2 R 14 , -S(O) 2 N(R 14 ) 2 , - NHC(O)OR 14 , -NHC(O)N(R 14 ) 2 , C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, -O-(C 1 -C 6 haloalkyl), - CN, -NO 2 , -N(R 14 ) 2 , -NH(C 1 -C 6 alkylene)-(5- or 6-membered monocyclic heteroaryl), -NH(C 1 -C 6 alkylene)-(9- or 10-membered bicyclic heteroaryl), -C(O)R 14 , -C(O)OR 14 , -C(O)N(R 14 ) 2 and - NHC(O)R 14 , wherein said C 2 -C 6 alkenyl group and said C 2 -C 6 alkynyl group may be optionally substituted with halo; each occurrence of R 12 is independently selected from H, C 1 -C 6 alkyl, -C(O)R 14 and -C(O)OR 14 ; each occurrence of R 13 is independently selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl and C 6 -C 10 aryl; each occurrence of R 14 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, -(C 1 -C 3 alkylene) n -(C 3 -C 7 cycloalkyl), -(C 1 -C 3 alkylene) n -(C 6 -C 10 aryl), -(C 1 -C 3 alkylene) n -(4 to 7-membered heterocycloalkyl), -(C 1 -C 3 alkylene) n -(5- or 6-membered monocyclic heteroaryl) and -(C 1 -C 3 alkylene) n -(9- or 10-membered bicyclic heteroaryl); m is 1, 2, 3, 4 or 5; and each occurrence of n is independently 0 or 1. A is O; B is selected from one of the following groups: Q is O; V is H, halo or -N(R 12 ) 2 ; W is N, CH or CF; R 1 is -(CH 2 ) m -C(O)OR 13 ; R 2 is methyl; R 3 is selected from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl and -N(R 12 ) 2 ; R 4 , R 5 , R 7 and R 8 are each independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, halo, -OR 14 , -SR 14 and -N(R 14 ) 2 ; R 6 , R 9 , R 10 and R 11 are each independently selected from H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 9- or 10-membered bicyclic heteroaryl, halo, -OR 14 , -SR 14 , -S(O)R 14 , -S(O) 2 R 14 , -S(O) 2 N(R 14 ) 2 , - NHC(O)OR 14 , -NHC(O)N(R 14 ) 2 , C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, -O-(C 1 -C 6 haloalkyl), - CN, -NO 2 , -N(R 14 ) 2 , -NH(C 1 -C 6 alkylene)-(5- or 6-membered monocyclic heteroaryl), -NH(C 1 -C 6 alkylene)-(9- or 10-membered bicyclic heteroaryl), -C(O)R 14 , -C(O)OR 14 , -C(O)N(R 14 ) 2 and - NHC(O)R 14 , wherein said C 2 -C 6 alkenyl group and said C 2 -C 6 alkynyl group may be optionally substituted with halo; each occurrence of R 12 is independently selected from H, C 1 -C 6 alkyl, -C(O)R 14 and -C(O)OR 14 ; each occurrence of R 13 is independently selected from C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl and C 6 -C 10 aryl; each occurrence of R 14 is independently selected from H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 hydroxyalkyl, -(C 1 -C 3 alkylene) n -(C 3 -C 7 cycloalkyl), -(C 1 -C 3 alkylene) n -(C 6 -C 10 aryl), -(C 1 -C 3 alkylene) n -(4 to 7-membered heterocycloalkyl), -(C 1 -C 3 alkylene) n -(5- or 6-membered monocyclic heteroaryl) and -(C 1 -C 3 alkylene) n -(9- or 10-membered bicyclic heteroaryl); m is 1, 2, 3, 4 or 5; and each occurrence of n is independently 0 or 1. <EOS>