mhurhangee/patent-ind-claim-en huggingface dataset:
A process for preparing a crystal form of chlorogenic acid, wherein the crystal form belongs to the orthorhombic system and space group P2 1 2 1 2 1 , with unit cell parameters: a = 7.7291 Å, b = 10.9808 Å, c = 36.5334 Å, α = β = γ = 90°, Z = 8, unit cell volume = 3100.65 Å 3 , characterized in that it includes the following method 1: Method 1: Taking chlorogenic acid with a purity of more than 98%, dissolving it in water, filtering, freeze-drying the filtrate, to obtain the crystal form of chlorogenic acid; wherein: in method 1, the conditions for freeze-drying are as follows: - a pre-freezing is done, wherein the temperature is in the range of from -20 °C to - 50°C, the pre-freezing time is in the range of from 1 h to 8 h; - the drying temperature is increased from the temperature in the range of from - 20°C to -50°C to 30°C, the warming time is in the range of from 8 h to 48 h; - drying at 30°C for another 1 h to 12 h, wherein the vacuum pressure is in the range of from 5 Pa to 40 Pa during freeze-drying. Method 1: Taking chlorogenic acid with a purity of more than 98%, dissolving it in water, filtering, freeze-drying the filtrate, to obtain the crystal form of chlorogenic acid; wherein: in method 1, the conditions for freeze-drying are as follows: - a pre-freezing is done, wherein the temperature is in the range of from -20 °C to - 50°C, the pre-freezing time is in the range of from 1 h to 8 h; - the drying temperature is increased from the temperature in the range of from - 20°C to -50°C to 30°C, the warming time is in the range of from 8 h to 48 h; - drying at 30°C for another 1 h to 12 h, wherein the vacuum pressure is in the range of from 5 Pa to 40 Pa during freeze-drying. in method 1, the conditions for freeze-drying are as follows: - a pre-freezing is done, wherein the temperature is in the range of from -20 °C to - 50°C, the pre-freezing time is in the range of from 1 h to 8 h; - the drying temperature is increased from the temperature in the range of from - 20°C to -50°C to 30°C, the warming time is in the range of from 8 h to 48 h; - drying at 30°C for another 1 h to 12 h, - a pre-freezing is done, wherein the temperature is in the range of from -20 °C to - 50°C, the pre-freezing time is in the range of from 1 h to 8 h; - the drying temperature is increased from the temperature in the range of from - 20°C to -50°C to 30°C, the warming time is in the range of from 8 h to 48 h; - drying at 30°C for another 1 h to 12 h, wherein the vacuum pressure is in the range of from 5 Pa to 40 Pa during freeze-drying.
A method for measuring multiple properties of a sample , the method including: providing an atomic force microscope (AFM) including a probe having a cantilever and a tip , wherein the probe has a sensitivity factor greater than 40, wherein the sensitivity factor is defined as Q/k, where Q is the mechanical quality factor and k is the spring constant of the cantilever , wherein the probe has a spring constant less than 1 N/m, wherein the probe is a capacitive probe that includes the cantilever made of a silicon nitride insulating lever and the tip made of a single homogenous doped silicon or pure metal material with the same crystalline structure throughout its volume extending therefrom and wherein pure metal is deposited on the backside or top surface of the cantilever to form a capacitor with the tip ; operating the AFM to cause the probe to interact with the sample in a two pass procedure; detecting, during a first pass of the two pass procedure, a surface of the sample by operating the AFM in Peak Force Tapping (PFT) Mode, and acquiring topography data and mechanical property data during the detecting step, wherein the control provided by PFT mode operates to keep the tip sample force at the PFT setpoint in order to yield signals indicative of mechanical properties of the surface of the sample as well as topography; and collecting, during a second pass of the two pass procedure, electrical property data corresponding to the sample with the probe using a Kelvin probe configuration, wherein the topography data collected in the acquiring step is used to perform said collecting electrical property data step. providing an atomic force microscope (AFM) including a probe having a cantilever and a tip , wherein the probe has a sensitivity factor greater than 40, wherein the sensitivity factor is defined as Q/k, where Q is the mechanical quality factor and k is the spring constant of the cantilever , wherein the probe has a spring constant less than 1 N/m, wherein the probe is a capacitive probe that includes the cantilever made of a silicon nitride insulating lever and the tip made of a single homogenous doped silicon or pure metal material with the same crystalline structure throughout its volume extending therefrom and wherein pure metal is deposited on the backside or top surface of the cantilever to form a capacitor with the tip ; operating the AFM to cause the probe to interact with the sample in a two pass procedure; detecting, during a first pass of the two pass procedure, a surface of the sample by operating the AFM in Peak Force Tapping (PFT) Mode, and acquiring topography data and mechanical property data during the detecting step, wherein the control provided by PFT mode operates to keep the tip sample force at the PFT setpoint in order to yield signals indicative of mechanical properties of the surface of the sample as well as topography; and collecting, during a second pass of the two pass procedure, electrical property data corresponding to the sample with the probe using a Kelvin probe configuration, wherein the topography data collected in the acquiring step is used to perform said collecting electrical property data step.
A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R 1 is (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy; R 2 is (C 1 -C 3 )alkyl; and R 3 is (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, hydroxy(C 1 -C 8 )alkyl, (C 1 -C 4 )alkoxy(C 1 -C 8 )alkyl-, (C 3 -C 5 )cycloalkyl, or (C 6 -C 10 )bicycloalkyl, wherein said (C 3 -C 5 )cycloalkyl or (C 6 -C 10 )bicycloalkyl are each optionally substituted by one or two groups independently selected from halogen, hydroxyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkyl, and halo(C 1 -C 4 )alkyl. R 1 is (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy; R 2 is (C 1 -C 3 )alkyl; and R 3 is (C 1 -C 8 )alkyl, halo(C 1 -C 8 )alkyl, hydroxy(C 1 -C 8 )alkyl, (C 1 -C 4 )alkoxy(C 1 -C 8 )alkyl-, (C 3 -C 5 )cycloalkyl, or (C 6 -C 10 )bicycloalkyl, wherein said (C 3 -C 5 )cycloalkyl or (C 6 -C 10 )bicycloalkyl are each optionally substituted by one or two groups independently selected from halogen, hydroxyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkyl, and halo(C 1 -C 4 )alkyl.
A method to quantitate the integrity of circulating cell free human DNA and implement a treatment of a patient, said method comprising: (a) providing a first and second sample of serum, plasma, urine, or other biological fluid from a subject wherein the first and second samples are obtained at least one week apart, at least 2 weeks apart, at least 3 weeks apart or at least 4 weeks apart, the first and second samples comprising cell free human DNA (cfDNA), the cfDNA comprising a first and second short retrotransposable interspersed element (RE) target sequence having a length of between about 60 base pairs to about 135 base pairs, wherein the first and second short targets differ in length; (b) quantitating each of the first and second short RE targets in the first and second samples using a quantitative polymerase chain reaction (qPCR) method; (c) obtaining for each of the quantitated RE targets in the first and second samples a threshold cycle number; (d) comparing the threshold cycle number of each quantitated RE target with a standard curve to determine an amount of each of the quantitated RE targets that were present in the samples, wherein the amount of short RE targets in the second samples is indicative of the integrity of the circulating cell free DNA; (e) determining an increase in the amount of short RE targets in the second sample as compared to the first sample above a threshold level, and (f) determining a treatment for a patient having an increase in the amount of short RE targets in the second sample as compared to the first sample above a threshold level. (a) providing a first and second sample of serum, plasma, urine, or other biological fluid from a subject wherein the first and second samples are obtained at least one week apart, at least 2 weeks apart, at least 3 weeks apart or at least 4 weeks apart, the first and second samples comprising cell free human DNA (cfDNA), the cfDNA comprising a first and second short retrotransposable interspersed element (RE) target sequence having a length of between about 60 base pairs to about 135 base pairs, wherein the first and second short targets differ in length; (b) quantitating each of the first and second short RE targets in the first and second samples using a quantitative polymerase chain reaction (qPCR) method; (c) obtaining for each of the quantitated RE targets in the first and second samples a threshold cycle number; (d) comparing the threshold cycle number of each quantitated RE target with a standard curve to determine an amount of each of the quantitated RE targets that were present in the samples, wherein the amount of short RE targets in the second samples is indicative of the integrity of the circulating cell free DNA; (e) determining an increase in the amount of short RE targets in the second sample as compared to the first sample above a threshold level, and (f) determining a treatment for a patient having an increase in the amount of short RE targets in the second sample as compared to the first sample above a threshold level.
Production method for producing a technical system , wherein the technical system has a plurality of subsystems (L1-L4) each with at least one module (M1-M8), comprising: determining a plurality of average required energy amounts (E) of each subsystem (L1-L4), wherein each of the plurality of average required energy amounts (E) corresponds to predefined clock cycles (C) of the at least one module (M1-M8) during the runtime of the technical system , determining a plurality of operating states (V1-V5) for each of the plurality of subsystems (L1-L4) taking into account setting possibilities of the modules (M1-M8) of each subsystem (L1-L4), wherein each operating state (V1-V5) stipulates one of the predefined clock cycles (C) of the at least one module (M1-M8) and a control program for the at least one module (M1-M8), storing the determined plurality of operating states (V1-V5) together with the respective required energy amount (E) for each subsystem (L1-L4), wherein each of the operating states (V1-V5) can be selected on the basis of at least one parameter during the runtime of the technical system , wherein the at least one parameter corresponds to at least one of a property of the stored operating states (V1-V5) and the required energy amount (E), and setting up the technical system on the basis of the plurality of determined operating states (V1-V5), wherein one of the plurality of determined operating states (V1-V5) is set up as a standard operating state. determining a plurality of average required energy amounts (E) of each subsystem (L1-L4), wherein each of the plurality of average required energy amounts (E) corresponds to predefined clock cycles (C) of the at least one module (M1-M8) during the runtime of the technical system , determining a plurality of operating states (V1-V5) for each of the plurality of subsystems (L1-L4) taking into account setting possibilities of the modules (M1-M8) of each subsystem (L1-L4), wherein each operating state (V1-V5) stipulates one of the predefined clock cycles (C) of the at least one module (M1-M8) and a control program for the at least one module (M1-M8), storing the determined plurality of operating states (V1-V5) together with the respective required energy amount (E) for each subsystem (L1-L4), wherein each of the operating states (V1-V5) can be selected on the basis of at least one parameter during the runtime of the technical system , wherein the at least one parameter corresponds to at least one of a property of the stored operating states (V1-V5) and the required energy amount (E), and setting up the technical system on the basis of the plurality of determined operating states (V1-V5), wherein one of the plurality of determined operating states (V1-V5) is set up as a standard operating state.
An apparatus for treating a cancerous target site, comprising: an electromagnetic emitter comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site, the electromagnetic emitter configured to provide a tumour treating field at a target site via the one or more electrodes, the tumour treating field being a non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1 pT and 1 mT; a heat source configured to provide heating at the target site to cause hyperthermia at the target site; and an electronic controller for electronically controlling the electromagnetic emitter and the heat source; wherein the apparatus is configured to apply the non-ionizing alternating electromagnetic field and the heating independently. an electromagnetic emitter comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site, the electromagnetic emitter configured to provide a tumour treating field at a target site via the one or more electrodes, the tumour treating field being a non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1 pT and 1 mT; a heat source configured to provide heating at the target site to cause hyperthermia at the target site; and an electronic controller for electronically controlling the electromagnetic emitter and the heat source;
A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 linked nucleosides and has a nucleobase sequence comprising 20 contiguous nucleobases complementary to an equal length portion of nucleobases 3533 to 3552 of SEQ ID NO: 3, wherein the nucleobase sequence of the modified oligonucleotide is 100% complementary to SEQ ID NO: 3; and wherein the conjugate group comprises:
A method for reducing a probability of an occurrence of a tailstrike for an aircraft , the method comprising: determining, by at least one processor of the aircraft , whether the tailstrike has a first probability of occurring by using tailstrike related data; and producing, by an aircraft tailstrike awareness system actuator , a tactile warning to a pilot of the aircraft , when the at least one processor determines that the tailstrike has the first probability of occurring, wherein the tactile warning is a resistant force applied to a pitch control inceptor in a cockpit of the aircraft , and characteristics of the tactile warning comprise at least one of: a magnitude of the resistant force is a function of actuator stroke, or there are at least two distinct force gradients for the actuator stroke. determining, by at least one processor of the aircraft , whether the tailstrike has a first probability of occurring by using tailstrike related data; and producing, by an aircraft tailstrike awareness system actuator , a tactile warning to a pilot of the aircraft , when the at least one processor determines that the tailstrike has the first probability of occurring, wherein the tactile warning is a resistant force applied to a pitch control inceptor in a cockpit of the aircraft , and characteristics of the tactile warning comprise at least one of: a magnitude of the resistant force is a function of actuator stroke, or there are at least two distinct force gradients for the actuator stroke.
Process for determining a plurality of different color quality indicators for a color control of a coating, wherein colorimetric coordinates of a color reference and colorimetric coordinates of the coating are ascertained for a plurality of different surface elements coated with the coating and control surface elements coated with the coating by a producer of the coating, in each case with a spectrophotometer for a number of measurement geometries and a number of light sources, wherein, for each measurement geometry of the number of measurement geometries and each light source of the number of light sources, respective color differences are calculated from the colorimetric coordinates of the color reference and the respective colorimetric coordinates of the coating for the plurality of the surface elements coated with the coating and of the control surface elements coated with the coating, wherein the respective colorimetric coordinates are normalized with respectively one weighting factor, wherein each of the plurality of color quality indicators is determined by means of a mapping, defined by a predetermined mapping prescription which is identical for all color quality indicators, of functional values onto a scale value of a predetermined scale which is identical for all color quality indicators, said functional values being determined for the number of measurement geometries and the number of light sources in each case by means of a mathematical relationship, specific to the respective color quality indicator, between color differences (in relation to the color reference) of at least one of the surface elements, wherein the mathematical relationship for at least one of the color quality indicators corresponds to a mathematical relationship between color differences in relation to the color reference of at least one of the surface elements and one of the control surface elements.
A method for graphically presenting sensor data from a plurality of wind power installations , comprising the steps of: - using a data interface of an apparatus to receive sensor data from wind power installations and/or wind farms connected to the data interface , - using a memory to store the received sensor data from the wind power installations and/or wind farms , - using input means , which are connected via an input interface , to select at least one time in the past, - using a display interface to output displays signals for the purpose of presenting geographical maps and sensor values using a display , and - using a data processing means to retrieve a plurality of sensor data or all sensor data for the selected time from the memory and using the display interface to output such display signals in order to use the display to present the retrieved sensor signals with a map in each case substantially at that position in the map which corresponds substantially to the geographical position of the wind power installation from which the respective sensor data were received. - using a data interface of an apparatus to receive sensor data from wind power installations and/or wind farms connected to the data interface , - using a memory to store the received sensor data from the wind power installations and/or wind farms , - using input means , which are connected via an input interface , to select at least one time in the past, - using a display interface to output displays signals for the purpose of presenting geographical maps and sensor values using a display , and - using a data processing means to retrieve a plurality of sensor data or all sensor data for the selected time from the memory and using the display interface to output such display signals in order to use the display to present the retrieved sensor signals with a map in each case substantially at that position in the map which corresponds substantially to the geographical position of the wind power installation from which the respective sensor data were received.
An artificial leather base material comprising: a non-woven fabric that is an entangled body of fibers (A) and fibers (B); and an elastic polymer applied inside the non-woven fabric, wherein the fibers (A) are crimped fibers that are formed from two types of resins with intrinsic viscosities different from each other, and that are filaments having an average fineness of 0.6 dtex or more, and the fibers (B) are ultrafine fibers having an average fineness of less than 0.6 dtex. a non-woven fabric that is an entangled body of fibers (A) and fibers (B); and an elastic polymer applied inside the non-woven fabric, wherein the fibers (A) are crimped fibers that are formed from two types of resins with intrinsic viscosities different from each other, and that are filaments having an average fineness of 0.6 dtex or more, and the fibers (B) are ultrafine fibers having an average fineness of less than 0.6 dtex.
A method for printing colour images using a colour workflow that results in equal colours from an existing print system and an additional print system, the existing print system applying an existing colour output profile for converting colours of an input image, the additional print system applying the colour workflow for converting colours of an input image, the method comprising the steps of: a) obtaining an additional output colour profile for the additional print system from colour measurement data that relate device colorant coordinates of the additional print system to device independent colour data; b) obtaining an actual output colour profile for the existing print system from colour measurement data that relate device colorant coordinates of the existing print system to device independent colour data; c) obtaining the existing output colour profile; d) combining the existing output colour profile, the actual output colour profile and the additional colour output profile in the colour workflow, and e) converting the colours of an input image according to the colour workflow and printing the converted image using the additional print system, wherein the existing output colour profile, in contrast to the actual output colour profile, does not accurately describe the colour behaviour of the existing print system as is apparent from the colour measurement data in step b) and the actual output colour profile is applied in an inverse direction (A2B) in the step of combining output colour profiles. a) obtaining an additional output colour profile for the additional print system from colour measurement data that relate device colorant coordinates of the additional print system to device independent colour data; b) obtaining an actual output colour profile for the existing print system from colour measurement data that relate device colorant coordinates of the existing print system to device independent colour data; c) obtaining the existing output colour profile; d) combining the existing output colour profile, the actual output colour profile and the additional colour output profile in the colour workflow, and e) converting the colours of an input image according to the colour workflow and printing the converted image using the additional print system,