A medical system, comprising: a) an interventional in-vivo instrument being a catheter or a guide-wire including a slave component (150-350) with a1) a controllable slave clock (153-353) configured to generate a slave clock signal (clk), a2) and a transmitter (151-351) configured to transmit a data signal (ds) of encoded data from sensors, actuators, and/or imaging devices that is clocked by the slave clock signal (clk) and wherein the slave clock signal is embedded in the data signal; b) an ex-vivo equipment including a master component (110-310) with b1) a receiver configured to receive said data signal (ds), b2) a master clock configured to generate a master clock signal (ref_clk), b3) and a clock controller (114, 115, 116-316), wherein the clock controller is configured to receive the master clock signal (ref_clk) and the data signal (ds), is configured to recover the slave clock signal at least partially from the data signal, and is configured to generate a clock control signal (ccs) for adjusting the slave clock (153-353) to the master clock by comparing the recovered slave clock signal with the master clock signal; and c) a link (101-301) via which the transmitter of the slave component is coupled to the receiver of the master component and the clock controller of the master component is coupled to the slave clock of the slave component so that the data signal (ds) and the clock control signal (ccs) can be exchanged. a) an interventional in-vivo instrument being a catheter or a guide-wire including a slave component (150-350) with a1) a controllable slave clock (153-353) configured to generate a slave clock signal (clk), a2) and a transmitter (151-351) configured to transmit a data signal (ds) of encoded data from sensors, actuators, and/or imaging devices that is clocked by the slave clock signal (clk) and wherein the slave clock signal is embedded in the data signal; a1) a controllable slave clock (153-353) configured to generate a slave clock signal (clk), a2) and a transmitter (151-351) configured to transmit a data signal (ds) of encoded data from sensors, actuators, and/or imaging devices that is clocked by the slave clock signal (clk) and wherein the slave clock signal is embedded in the data signal; b) an ex-vivo equipment including a master component (110-310) with b1) a receiver configured to receive said data signal (ds), b2) a master clock configured to generate a master clock signal (ref_clk), b3) and a clock controller (114, 115, 116-316), wherein the clock controller is configured to receive the master clock signal (ref_clk) and the data signal (ds), is configured to recover the slave clock signal at least partially from the data signal, and is configured to generate a clock control signal (ccs) for adjusting the slave clock (153-353) to the master clock by comparing the recovered slave clock signal with the master clock signal; and b1) a receiver configured to receive said data signal (ds), b2) a master clock configured to generate a master clock signal (ref_clk), b3) and a clock controller (114, 115, 116-316), wherein the clock controller is configured to receive the master clock signal (ref_clk) and the data signal (ds), is configured to recover the slave clock signal at least partially from the data signal, and is configured to generate a clock control signal (ccs) for adjusting the slave clock (153-353) to the master clock by comparing the recovered slave clock signal with the master clock signal; and c) a link (101-301) via which the transmitter of the slave component is coupled to the receiver of the master component and the clock controller of the master component is coupled to the slave clock of the slave component so that the data signal (ds) and the clock control signal (ccs) can be exchanged. <EOS>