A compound represented by the following Formula 1, or an optical isomer, a stereoisomer or an isotopic variant thereof, or a pharmaceutically acceptable salt thereof: wherein Xis CH or N; n is an integer from 0 to 2; R 1 is -D-R 9 or wherein D is a direct bond, -CH 2 -, -O- or -C=C-; R 9 is halo, hydroxy, alkyl, hydroxyalkyl, dialkylaminoalkyl, saturated or unsaturated heterocyclyl, or saturated heterocyclyl-alkyl; the saturated or unsaturated heterocyclyl may be substituted with one or more substituents selected from halo, alkyl, alkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl and saturated heterocyclyl; R 10 and R 11 are each independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, cycloalkyl-alkyl, alkylcarbonyl, hydroxyalkylcarbonyl, aralkyl, saturated heterocyclyl, saturated or unsaturated heterocyclyl-alkyl, unsaturated heterocyclyl-carbonyl, or saturated heterocyclyl-alkylcarbonyl; or R 10 and R 11 together with nitrogen (N) atom to which they are attached may form saturated or unsaturated heterocyclyl; the saturated or unsaturated heterocyclyl may be substituted with one or more substituents selected from hydroxy, oxo, formyl (-CHO), cyano, alkyl, alkoxy, hydroxyalkyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylamino, alkylsulfonyl, alkoxyalkyl, aminocarbonyl, alkylcarbonylamino, alkylcarbonylalkylamino, alkoxyalkylalkylamino, dialkylamino, dialkylaminoalkyl, dialkylaminoalkoxy, dialkylaminocarbonyl and 4- to 10-membered, saturated heterocyclyl; R 2 is hydrogen or halo; R 3 is hydrogen, halo or alkyl, or together with carbon (C) atom to which they are attached may form cycloalkyl when n is 2; R 4 , R 5 , R 6 and R 7 are each independently hydrogen or alkyl; and R 8 is hydrogen, halo, alkyl, alkoxy or amino. Xis CH or N; n is an integer from 0 to 2; R 1 is -D-R 9 or wherein D is a direct bond, -CH 2 -, -O- or -C=C-; R 9 is halo, hydroxy, alkyl, hydroxyalkyl, dialkylaminoalkyl, saturated or unsaturated heterocyclyl, or saturated heterocyclyl-alkyl; the saturated or unsaturated heterocyclyl may be substituted with one or more substituents selected from halo, alkyl, alkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, alkoxycarbonyl and saturated heterocyclyl; R 10 and R 11 are each independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, cycloalkyl-alkyl, alkylcarbonyl, hydroxyalkylcarbonyl, aralkyl, saturated heterocyclyl, saturated or unsaturated heterocyclyl-alkyl, unsaturated heterocyclyl-carbonyl, or saturated heterocyclyl-alkylcarbonyl; or R 10 and R 11 together with nitrogen (N) atom to which they are attached may form saturated or unsaturated heterocyclyl; the saturated or unsaturated heterocyclyl may be substituted with one or more substituents selected from hydroxy, oxo, formyl (-CHO), cyano, alkyl, alkoxy, hydroxyalkyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylamino, alkylsulfonyl, alkoxyalkyl, aminocarbonyl, alkylcarbonylamino, alkylcarbonylalkylamino, alkoxyalkylalkylamino, dialkylamino, dialkylaminoalkyl, dialkylaminoalkoxy, dialkylaminocarbonyl and 4- to 10-membered, saturated heterocyclyl; R 2 is hydrogen or halo; R 3 is hydrogen, halo or alkyl, or together with carbon (C) atom to which they are attached may form cycloalkyl when n is 2; R 4 , R 5 , R 6 and R 7 are each independently hydrogen or alkyl; and R 8 is hydrogen, halo, alkyl, alkoxy or amino. <EOS>