A compound of the following Formula , or a pharmaceutically acceptable salt or stereoisomer thereof: wherein A, B and E are each independently CH or N; D is N, CH or C-halo-C 1 -C 7 alkyl; R 1 is C 1 -C 7 alkyl, C 3 -C 10 cycloalkyl or halo-C 1 -C 7 alkyl; R 2 is hydrogen or C 1 -C 7 alkyl; R 3 is -G-J-L; wherein G is -NH- or a direct bond; J is C 1 -C 7 alkylene, C 2 -C 7 alkenylene, C 1 -C 7 alkylene-C 6 -C 10 arylene, C 1 -C 7 alkylene-amino-C 6 -C 10 arylene, C 1 -C 7 alkylene-C 6 -C 10 aryloxylene-C 1 -C 7 alkylene, C 1 -C 7 alkylene-C 3 -C 10 cycloalkyl, C 2 -C 7 alkenylene-C 3 -C 10 cycloalkyl, C 1 -C 7 alkoxylene-C 6 -C 10 arylene, C 6 -C 10 arylene, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 7 alkyl, 5- to 12-membered heterocycloalkylene, 5- to 12-membered heterocycloalkylene-C 6 -C 10 arylene, 5- to 12-membered heterocycloalkylene-5- to 12-membered heteroarylene or 5-to 12-membered heterocycloalkyl; L is hydrogen, halo, amino, nitro, carboxy (-COOH), aminocarbonyl-C 1 -C 7 alkyl, carboxy-C 1 -C 7 alkyl, carboxy-C 1 -C 7 alkoxy, carboxy-C 1 -C 7 alkyl-C 6 -C 10 aryl, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, C 6 -C 10 aryloxy, 5- to 12-membered heterocycloalkyl or 5- to 12-membered heteroaryl; or R 2 and R 3 together with nitrogen atom to which they are attached may form 5-to 12-membered heterocycloalkyl; wherein the alkyl, alkylene, alkylene-arylene, alkenyl, alkenylene, cycloalkyl, carboxyalkyl, carboxyalkoxy, alkoxyalkyl, aminocarbonyl, aryl, aryl-alkyl, arylene, aryloxy, heterocycloalkyl or heteroaryl is optionally substituted with 1 to 4 substituents selected from hydroxy, halo, oxo, nitro, -COOH, -CH 2 COOH, C 1 -C 7 alkyl, C 2 -C 7 alkenyl, C 1 -C 7 alkoxy, halo-C 1 -C 7 alkyl, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylcarbonyl, C 1 -C 7 alkoxycarbonyl and 5- to 12-membered heteroaryl-C 1 -C 7 alkyl; and the heterocycloalkylene, heterocycloalkyl, heteroarylene or heteroaryl includes 1 to 5 heteroatoms selected from N, O and S. A, B and E are each independently CH or N; D is N, CH or C-halo-C 1 -C 7 alkyl; R 1 is C 1 -C 7 alkyl, C 3 -C 10 cycloalkyl or halo-C 1 -C 7 alkyl; R 2 is hydrogen or C 1 -C 7 alkyl; R 3 is -G-J-L; wherein G is -NH- or a direct bond; J is C 1 -C 7 alkylene, C 2 -C 7 alkenylene, C 1 -C 7 alkylene-C 6 -C 10 arylene, C 1 -C 7 alkylene-amino-C 6 -C 10 arylene, C 1 -C 7 alkylene-C 6 -C 10 aryloxylene-C 1 -C 7 alkylene, C 1 -C 7 alkylene-C 3 -C 10 cycloalkyl, C 2 -C 7 alkenylene-C 3 -C 10 cycloalkyl, C 1 -C 7 alkoxylene-C 6 -C 10 arylene, C 6 -C 10 arylene, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 7 alkyl, 5- to 12-membered heterocycloalkylene, 5- to 12-membered heterocycloalkylene-C 6 -C 10 arylene, 5- to 12-membered heterocycloalkylene-5- to 12-membered heteroarylene or 5-to 12-membered heterocycloalkyl; L is hydrogen, halo, amino, nitro, carboxy (-COOH), aminocarbonyl-C 1 -C 7 alkyl, carboxy-C 1 -C 7 alkyl, carboxy-C 1 -C 7 alkoxy, carboxy-C 1 -C 7 alkyl-C 6 -C 10 aryl, C 3 -C 10 cycloalkyl, C 6 -C 10 aryl, C 6 -C 10 aryloxy, 5- to 12-membered heterocycloalkyl or 5- to 12-membered heteroaryl; or R 2 and R 3 together with nitrogen atom to which they are attached may form 5-to 12-membered heterocycloalkyl; wherein the alkyl, alkylene, alkylene-arylene, alkenyl, alkenylene, cycloalkyl, carboxyalkyl, carboxyalkoxy, alkoxyalkyl, aminocarbonyl, aryl, aryl-alkyl, arylene, aryloxy, heterocycloalkyl or heteroaryl is optionally substituted with 1 to 4 substituents selected from hydroxy, halo, oxo, nitro, -COOH, -CH 2 COOH, C 1 -C 7 alkyl, C 2 -C 7 alkenyl, C 1 -C 7 alkoxy, halo-C 1 -C 7 alkyl, C 1 -C 7 alkylsulfonyl, C 1 -C 7 alkylcarbonyl, C 1 -C 7 alkoxycarbonyl and 5- to 12-membered heteroaryl-C 1 -C 7 alkyl; and the heterocycloalkylene, heterocycloalkyl, heteroarylene or heteroaryl includes 1 to 5 heteroatoms selected from N, O and S. <EOS>