System for automatic exchange of chromatographic columns which are made of a fritless fused silica capillary for keeping a stationary phase inside the column , wherein the fused silica capillary is coated with a polymeric shell , preferably polyimide, the system includes: - a magazine , wherein a holder for at least one column is placed, the holder comprising sealing ferrules integrated at both ends of the holder , the sealing ferrules configured to surround said column having a cylindrical shape or a shape similar to a cylinder, the holder comprising a through-hole for the column , the column being placeable along an axis of the holder in the through-hole for the column ; - a socket wherein the column holder with the column is seated in a working position, wherein the socket is located in lower part of the magazine , the socket configured to receive from the upper part of the magazine the column in the holder , wherein the column in the holder is fed by gravity into the socket during column exchange, wherein the magazine with the socket is mounted on a base between actuators attached to the base , the actuators lying in one axis with the column in the working position, the system further comprising a housing of the magazine , the housing comprising, at the height of the socket in the axis of the actuators , openings that provide access to the column ; - to each actuator from the side of the magazine a sealing union is attached, lying in one axis with the column , which has a sealing coned receiving ports with tubing pocket on the side of the column and receiving ports with tubing pocket with mounting thread on the opposite side. - a magazine , wherein a holder for at least one column is placed, the holder comprising sealing ferrules integrated at both ends of the holder , the sealing ferrules configured to surround said column having a cylindrical shape or a shape similar to a cylinder, the holder comprising a through-hole for the column , the column being placeable along an axis of the holder in the through-hole for the column ; - a socket wherein the column holder with the column is seated in a working position, wherein the socket is located in lower part of the magazine , the socket configured to receive from the upper part of the magazine the column in the holder , wherein the column in the holder is fed by gravity into the socket during column exchange, wherein the magazine with the socket is mounted on a base between actuators attached to the base , the actuators lying in one axis with the column in the working position, the system further comprising a housing of the magazine , the housing comprising, at the height of the socket in the axis of the actuators , openings that provide access to the column ; wherein the magazine with the socket is mounted on a base between actuators attached to the base , the actuators lying in one axis with the column in the working position, the system further comprising a housing of the magazine , the housing comprising, at the height of the socket in the axis of the actuators , openings that provide access to the column ; - to each actuator from the side of the magazine a sealing union is attached, lying in one axis with the column , which has a sealing coned receiving ports with tubing pocket on the side of the column and receiving ports with tubing pocket with mounting thread on the opposite side. <EOS>