A method of sequencing a target nucleic acid, comprising: (a) providing an apparatus comprising: (i) a solid support comprising an array of solid state nanopores, wherein the solid state nanopores form apertures between reservoirs that are separated by the solid support, (ii) a plurality of lipid nanodiscs on a surface of the solid support, wherein each of the lipid nanodiscs forms a seal at one of the solid state nanopores, wherein the lipid nanodiscs are separated from each other by interstitial regions on the surface of the solid support, wherein the interstitial regions are devoid of any lipid material, wherein each of the lipid nanodiscs is a lipid bilayer disc stabilized by membrane scaffold protein (MSP) and (iii) a plurality of protein nanopores inserted in the lipid nanodiscs to create apertures in each of the seals; and (b) detecting passage of a nucleic acid species through the apertures, wherein the nucleic acid species is selected from the group consisting of: (i) a polynucleotide, (ii) a series of nucleotides removed from the nucleic acid, and (iii) a series of probes derived from nucleotides incorporated into the nucleic acid; thereby determining the sequence of the target nucleic acid. (a) providing an apparatus comprising: (i) a solid support comprising an array of solid state nanopores, wherein the solid state nanopores form apertures between reservoirs that are separated by the solid support, (ii) a plurality of lipid nanodiscs on a surface of the solid support, wherein each of the lipid nanodiscs forms a seal at one of the solid state nanopores, wherein the lipid nanodiscs are separated from each other by interstitial regions on the surface of the solid support, wherein the interstitial regions are devoid of any lipid material, wherein each of the lipid nanodiscs is a lipid bilayer disc stabilized by membrane scaffold protein (MSP) and (iii) a plurality of protein nanopores inserted in the lipid nanodiscs to create apertures in each of the seals; and (i) a solid support comprising an array of solid state nanopores, wherein the solid state nanopores form apertures between reservoirs that are separated by the solid support, (ii) a plurality of lipid nanodiscs on a surface of the solid support, wherein each of the lipid nanodiscs forms a seal at one of the solid state nanopores, wherein the lipid nanodiscs are separated from each other by interstitial regions on the surface of the solid support, wherein the interstitial regions are devoid of any lipid material, wherein each of the lipid nanodiscs is a lipid bilayer disc stabilized by membrane scaffold protein (MSP) and (iii) a plurality of protein nanopores inserted in the lipid nanodiscs to create apertures in each of the seals; and (b) detecting passage of a nucleic acid species through the apertures, wherein the nucleic acid species is selected from the group consisting of: (i) a polynucleotide, (ii) a series of nucleotides removed from the nucleic acid, and (iii) a series of probes derived from nucleotides incorporated into the nucleic acid; (i) a polynucleotide, (ii) a series of nucleotides removed from the nucleic acid, and (iii) a series of probes derived from nucleotides incorporated into the nucleic acid; <EOS>