mhurhangee/patent-ind-claim-en huggingface dataset:
A hypoxia-inducible factor (HIF) activator, or a pharmaceutically acceptable salt or solvate thereof, for use in promoting tissue repair in epithelial cells, wherein the HIF activator is selected from a group consisting of: dimethyloxalylglycine (DMOG); N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine (IOX); N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine (BIQ); desferrioxamine (DFX); o-phenanthroline; iodochlorohydroxyquinoline; and cobalt chloride heptahydrate, or a pharmaceutically acceptable salt or solvate thereof, and is to be used with a prototypical tissue-protective cytokine, wherein the prototypical tissue-protective cytokine is erythropoietin (EPO), or an analogue or derivative thereof, interleukin 3 (IL-3), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 11 (IL-11), leukaemia inhibitory factor (LIF) or a colony stimulating factor (CSF) or a pharmaceutically acceptable salt or solvate thereof, which is administered exogenously to the body being treated, wherein the derivative of EPO is desialylated EPO, carbamylated EPO (CEPO), asialoerythropoietin (asialoEPO), glutaraldehyde EPO (GEPO), epopeptide AB, an isoform of EPO, recombinant EPO, mutant S100E of EPO, and the analogue of EPO is pyroglutamate helix B surface peptide (pHBSP).
Heel unit for a slide board binding, comprising a base with a fastening arrangement for attachment to a slide board surface, a binding body mounted on the base , two coupling pins arranged adjacent to one another for engagement in recesses of a heel section of a shoe in order to fix the shoe to the heel unit , wherein the coupling pins protrude from the binding body in a downhill skiing position of the binding body in a slide board longitudinal direction (X), in particular in a forward direction of travel, and at least one of the coupling pins is movable relative to the other coupling pin between a downhill skiing position and a frontal release position, and a frontal release arrangement which is adapted to bias the at least one of the coupling pins towards its downhill skiing position, characterised in that the frontal release arrangement comprises at least one torsion spring , which provides a tensioning force for the frontal release arrangement . a base with a fastening arrangement for attachment to a slide board surface, a binding body mounted on the base , two coupling pins arranged adjacent to one another for engagement in recesses of a heel section of a shoe in order to fix the shoe to the heel unit , wherein the coupling pins protrude from the binding body in a downhill skiing position of the binding body in a slide board longitudinal direction (X), in particular in a forward direction of travel, and at least one of the coupling pins is movable relative to the other coupling pin between a downhill skiing position and a frontal release position, and a frontal release arrangement which is adapted to bias the at least one of the coupling pins towards its downhill skiing position, characterised in that the frontal release arrangement comprises at least one torsion spring , which provides a tensioning force for the frontal release arrangement .
A high strength hot rolled steel sheet with excellent warm stamp formability, the high strength hot rolled steel sheet having a high strength of a tensile strength of 590 MPa or more and tensile properties in which the local elongation being the strain from the indication of the maximum load to fracture is larger than the uniform elongation being the strain before the indication of the maximum load from the start of tensile test obtained in a tensile test carried out at a test temperature of 400°C or higher and the uniform elongation being the strain before the indication of the maximum load from the start of tensile test is 40% or more in terms of a ratio to the the total elongation being the total strain from the start of tensile test to fracture obtained in a tensile test carried out at a test temperature of lower than 400°C, all measured from stress-strain curves in accordance with JIS G 0567, the high strength hot rolled steel sheet comprising a composition consisting of, in terms of % by mass, C: 0.01 to 0.2%, Si: 0.5% or lower, Mn: 0.1 to 2%, P: 0.03% or lower, S: 0.01% or lower, Al: 0.01 to 0.07%, and N: 0.01% or lower, two or more elements selected from Ti: 0.005 to 0.3%, Nb: 0.005 to 0.6%, V: 0.005 to 1.0%, Mo: 0.005 to 0.5%, W: 0.01 to 1.0%, and B: 0.0005 to 0.0040%, optionally Cu : 0.1% or lower, optionally Ni : 0.1% or lower, optionally Sn : 0.1% or lower, optionally Mg : 0.01% or lower, optionally Sb : 0.01% or lower, optionally Co : 0.01% or lower, and the balance being Fe and inevitable impurities, and the high strength hot rolled steel sheet comprising: a matrix, which is substantially a ferrite single phase in which the area ratio of the ferrite phase is 95% or more; and a structure in which alloy carbides having a size of lower than 10 nm are dispersed and deposited in the matrix in a state having no variant selection which is a state in which the orientation of carbides is not uniform to the base phase. a matrix, which is substantially a ferrite single phase in which the area ratio of the ferrite phase is 95% or more; and a structure in which alloy carbides having a size of lower than 10 nm are dispersed and deposited in the matrix in a state having no variant selection which is a state in which the orientation of carbides is not uniform to the base phase.
A safety cutting device comprising: an elongate housing defining a sheath having an anterior opening and a posterior opening and forming a cavity configured to receive a slidable insert ; a cutting blade coupled to the slidable insert , the slidable insert positioned within the cavity and moveable within the housing between a safe position in which the blade is covered by the sheath and an exposed position in which the blade is extended through the anterior opening and exposed for cutting; a biasing member biasing the slidable insert to the safe position; the slidable insert includes a posterior activation mechanism, the posterior mechanism including a longitudinal post and a rearward facing engagement surface , wherein a portion of said posterior activation mechanism extends through the posterior opening and extends to a position posterior to the posterior opening , wherein the longitudinal post and the rearward facing engagement surface are accessible for moving the slidable insert from the safe position to the exposed position by longitudinally moving the longitudinal post and rearward facing engagement surface toward the anterior opening; a protective cover that extends posterior to the posterior activation mechanism and impedes accidental actuation thereof; a latch mechanism operable to lock the slidable insert in the exposed position; and a release mechanism configured to unlock the latch mechanism. an elongate housing defining a sheath having an anterior opening and a posterior opening and forming a cavity configured to receive a slidable insert ; a cutting blade coupled to the slidable insert , the slidable insert positioned within the cavity and moveable within the housing between a safe position in which the blade is covered by the sheath and an exposed position in which the blade is extended through the anterior opening and exposed for cutting; a biasing member biasing the slidable insert to the safe position; the slidable insert includes a posterior activation mechanism, the posterior mechanism including a longitudinal post and a rearward facing engagement surface , wherein a portion of said posterior activation mechanism extends through the posterior opening and extends to a position posterior to the posterior opening , wherein the longitudinal post and the rearward facing engagement surface are accessible for moving the slidable insert from the safe position to the exposed position by longitudinally moving the longitudinal post and rearward facing engagement surface toward the anterior opening; a protective cover that extends posterior to the posterior activation mechanism and impedes accidental actuation thereof; a latch mechanism operable to lock the slidable insert in the exposed position; and a release mechanism configured to unlock the latch mechanism.
Foot movement damping device for damping a foot movement via the ankle joint, comprising a support arrangement for supporting on a lower leg or from proximally on the ankle bone , a retaining arrangement for retention on a foot , and a damping element for damping a relative movement between the support arrangement and the retaining arrangement , wherein the retaining arrangement comprises an articulated mounting , wherein the damping element is held at one end on the articulated mounting , and the damping element is attached to the support arrangement via at least one attachment element , wherein the articulated mounting is configured in such a way that the damping element is attached to the retaining arrangement so as to be displaceable relative to the latter within a predefined range, characterized in that at least one attachment element is attached to the support arrangement at two different attachment points , and wherein the damping element is held displaceably on the at least one attachment element , wherein the at least one attachment element preferably extends from one attachment point to the other attachment point , and the damping element is attached to the attachment element between the two attachment points .
A method of fabricating a book-like document of value and/or security document, - in which a book case and a book block comprising an end paper and at least one data page connected therewith are fit together, and - in which the book block and the book case are joined together by means of an adhesive, - a double-sided adhesive layer material web being applied to an inner surface of the book case or to an outer surface of the end paper , and - the end paper and the book case being aligned, fit together, and permanently joined to each other, - the double-sided adhesive layer material web being cut to a length which is shorter than the length of a base size of the book case or of the end paper , characterised in that - the double-sided adhesive layer material web is cut to a width, or provided with a predefined width, which is smaller than the width of the base size of the book case or of the end paper , and - once the book block and the book case have been joined together, the document , which has been produced in a base size, is cut to its finished size while in a flipped-opened or closed configuration. - in which a book case and a book block comprising an end paper and at least one data page connected therewith are fit together, and - in which the book block and the book case are joined together by means of an adhesive, - a double-sided adhesive layer material web being applied to an inner surface of the book case or to an outer surface of the end paper , and - the end paper and the book case being aligned, fit together, and permanently joined to each other, - the double-sided adhesive layer material web being cut to a length which is shorter than the length of a base size of the book case or of the end paper , characterised in that - the double-sided adhesive layer material web is cut to a width, or provided with a predefined width, which is smaller than the width of the base size of the book case or of the end paper , and - once the book block and the book case have been joined together, the document , which has been produced in a base size, is cut to its finished size while in a flipped-opened or closed configuration.
An aerosolization system, comprising: an aerosol generator including a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane ; a housing defining a mouthpiece, the housing including a receptacle configured to at least partially receive a liquid drug cartridge and interface with the liquid drug cartridge to position an ejection opening of the liquid drug cartridge to dispense liquid drug directly onto the rear face of the vibratable membrane to be aerosolized by controlled vibration of the vibratable element; an actuator configured to reposition a piston of the liquid drug cartridge to dispense a dosage of the drug via the ejection opening to the rear face of the vibratable membrane , a mixing chamber in fluid communication with the front face of the vibratable membrane and the mouthpiece; characterised in that the system further comprises one or more air inlets in fluid communication with the mixing chamber and configured to inlet air into the mixing chamber in response to a user inhaling via the mouthpiece; and an air flow restrictor array having greater resistance to air flow than the one or more air inlets and placing the mixing chamber in fluid communication with the one or more air inlets . an aerosol generator including a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane ; a housing defining a mouthpiece, the housing including a receptacle configured to at least partially receive a liquid drug cartridge and interface with the liquid drug cartridge to position an ejection opening of the liquid drug cartridge to dispense liquid drug directly onto the rear face of the vibratable membrane to be aerosolized by controlled vibration of the vibratable element; an actuator configured to reposition a piston of the liquid drug cartridge to dispense a dosage of the drug via the ejection opening to the rear face of the vibratable membrane , a mixing chamber in fluid communication with the front face of the vibratable membrane and the mouthpiece; characterised in that the system further comprises one or more air inlets in fluid communication with the mixing chamber and configured to inlet air into the mixing chamber in response to a user inhaling via the mouthpiece; and an air flow restrictor array having greater resistance to air flow than the one or more air inlets and placing the mixing chamber in fluid communication with the one or more air inlets .
A composition comprising: (A) a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt% of propylene monomer units and at most 10 wt% of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms and (B) an elastomer of ethylene and α-olefin comonomer having 4 to 10 carbon atoms, wherein the elastomer has a density of 0.850 to 0.910 g/cm 3 and a melt flow rate of 15 to 50 dg/min measured in accordance with ISO1133 using a 2.16 kg weight and at a temperature of 190 °C, wherein the amount of (A) the propylene-based polymer is 60 to 99 wt% and the amount of (B) the elastomer is 1 to 40 wt%, with respect to the total composition, wherein the propylene-based polymer (A) is a random propylene-ethylene copolymer consisting of 90-99 wt% of propylene monomer units and 1-10 wt% of ethylene monomer units. (A) a propylene-based polymer which is a propylene homopolymer or a propylene copolymer consisting of at least 90 wt% of propylene monomer units and at most 10 wt% of ethylene monomer units and/or an α-olefin monomer units having 4 to 10 carbon atoms and (B) an elastomer of ethylene and α-olefin comonomer having 4 to 10 carbon atoms, wherein the elastomer has a density of 0.850 to 0.910 g/cm 3 and a melt flow rate of 15 to 50 dg/min measured in accordance with ISO1133 using a 2.16 kg weight and at a temperature of 190 °C,
Device for boring and extending a tunnel along a specified target trajectory, comprising a cutting wheel for excavating a heading face , comprising a number of presses that are arranged on the side of the cutting wheel that faces away from a heading face , that operate in an axial direction, that are held by a press bearing against which the cutting wheel is supported in the axial direction, and that are designed to press against lining segments with pressing forces on the side of the press bearing that faces away from the cutting wheel , wherein at least some presses are connected to a converter module for measuring a pressure value assigned to a pressing force exerted on a lining segment , wherein a central unit is provided and has a central control module to which the converter modules are connected for transmitting the pressure values, wherein the central unit further comprises a navigation measurement module as well as a pressing force correction module and wherein, in the event of a deviation of the future trajectory or an actual trajectory from the target trajectory specified by the navigation measurement module , the pressing forces exerted by the presses can be adjusted by means of the pressing force correction module in order to stabilise an actual force focal point resulting from the exerted pressing forces such that the deviation of the future trajectory from the target trajectory decreases with respect to the initial trajectory prediction, characterised in that a navigation prediction module is provided, by means of which an initial trajectory prediction relating to a future trajectory can be determined at at least one determined distribution of the pressing forces exerted by the presses during installation of lining segments that adjoin in the circumferential direction for the purpose of continuously boring and extending until a ring of lining segments is formed, in that the deviation of the actual force focal point of all pressing forces from a target force focal point can be determined in order to determine the trajectory prediction by means of the navigation prediction module , and in that the deviation of the actual force focal point from the target force focal point is a controlled variable of a control loop comprising the pressing force correction module , the navigation prediction module and the central control module , wherein the new pressing forces are calculated in advance for a period from the beginning of installation of a lining segment to the completion of installation of said lining segment and thus to the beginning of installation of the next lining segment , such that the trajectory prediction determined by the navigation prediction module takes place for the period in which new lining segments are installed at least when the actual trajectory is approaching the target trajectory on account of stabilisation of the actual force focal point .
A seal damper for a plurality of circumferentially spaced blades comprising: a base section extending along an axial dimension from a first axial end (LE) to an opposing second axial end (TE), the base section joining a first arm (S1) projecting from the first axial end (LE) and a second arm (S2) projecting from the second axial end (TE), the first arm (S1) including a free end having a pair of spaced apart shoulders projecting therefrom; characterised in that : the seal damper further comprises a tab projecting forwardly from the free end of the first arm (S1). a base section extending along an axial dimension from a first axial end (LE) to an opposing second axial end (TE), the base section joining a first arm (S1) projecting from the first axial end (LE) and a second arm (S2) projecting from the second axial end (TE), the first arm (S1) including a free end having a pair of spaced apart shoulders projecting therefrom; characterised in that : the seal damper further comprises a tab projecting forwardly from the free end of the first arm (S1).
An amplified tunable laser source, comprising a tunable laser and an optical amplifier, and configured to emit an input tunable radiation having an input power spectrum, an input center wavelength, input wavelength range and input average power, optically coupled to an input side of a semiconductor optical amplifier comprising at least one quantum well, and an output tunable radiation having an output power spectrum, an output center wavelength, an output wavelength range, and output average power, emerging from an output side of said optical amplifier, wherein the optical amplifier is configured to amplify the input tunable radiation and generate the output tunable radiation; the tunable laser is configured to generate the input tunable radiation; the tunable laser comprising an optical cavity including a first and second mirror ; a gain region interposed between said first and second mirrors ; a tuning region ; and means for adjusting an optical path length of said tuning region; wherein: a free spectral range (FSR) of said optical cavity exceeds 5% of said input center wavelength; said tunable laser operates substantially in a single longitudinal and transverse mode over said wavelength range; said means for adjusting an optical path length has a wavelength tuning frequency response with a 6-dB bandwidth greater than about 1 kHz; and said optical amplifier is a resonant tunable optical amplifier configured to be tuned synchronously with said input tunable radiation, such that the passband of the optical amplifier is aligned at all times with the wavelength of the input tunable radiation. the optical amplifier is configured to amplify the input tunable radiation and generate the output tunable radiation; the tunable laser is configured to generate the input tunable radiation; the tunable laser comprising an optical cavity including a first and second mirror ; a gain region interposed between said first and second mirrors ; a tuning region ; and means for adjusting an optical path length of said tuning region; a free spectral range (FSR) of said optical cavity exceeds 5% of said input center wavelength; said tunable laser operates substantially in a single longitudinal and transverse mode over said wavelength range; said means for adjusting an optical path length has a wavelength tuning frequency response with a 6-dB bandwidth greater than about 1 kHz; and said optical amplifier is a resonant tunable optical amplifier configured to be tuned synchronously with said input tunable radiation, such that the passband of the optical amplifier is aligned at all times with the wavelength of the input tunable radiation.