mhurhangee/patent-ind-claim-en huggingface dataset:
A method of detennining copy number variation in a sample that includes cell-free polynucleotides, the method comprising: a. providing at least two sets of cell-free polynucleotides, which map to different mappable positions in a reference sequence in a genome, and, for the sets of cell-free polynucleotides; i. non-uniquely tagging the cell-free polynucleotides with a set of molecular barcodes; ii. amplifying the cell-free polynucleotides to produce amplified polynucleotides; iii. sequencing a subset of the set of amplified polynucleotides, to produce a set of sequencing reads; iv. grouping the set of sequencing reads sequenced from amplified polynucleotides into families which correspond to sequencing reads of polynucleotides amplified from the same cell-free polynucleotide; v. inferring a quantitative measure of families in the sets; and b. detennining copy number variation based on the quantitative measure of families in the sets. a. providing at least two sets of cell-free polynucleotides, which map to different mappable positions in a reference sequence in a genome, and, for the sets of cell-free polynucleotides; i. non-uniquely tagging the cell-free polynucleotides with a set of molecular barcodes; ii. amplifying the cell-free polynucleotides to produce amplified polynucleotides; iii. sequencing a subset of the set of amplified polynucleotides, to produce a set of sequencing reads; iv. grouping the set of sequencing reads sequenced from amplified polynucleotides into families which correspond to sequencing reads of polynucleotides amplified from the same cell-free polynucleotide; v. inferring a quantitative measure of families in the sets; and i. non-uniquely tagging the cell-free polynucleotides with a set of molecular barcodes; ii. amplifying the cell-free polynucleotides to produce amplified polynucleotides; iii. sequencing a subset of the set of amplified polynucleotides, to produce a set of sequencing reads; iv. grouping the set of sequencing reads sequenced from amplified polynucleotides into families which correspond to sequencing reads of polynucleotides amplified from the same cell-free polynucleotide; v. inferring a quantitative measure of families in the sets; and b. detennining copy number variation based on the quantitative measure of families in the sets.
A method for detecting an analyte using surface enhanced Raman spectroscopy (SERS), the method comprising a) contacting one or more analyte-binding molecules with the analyte under conditions that allow binding of the analyte to the one or more analyte-binding molecules to form a first mixture, wherein the one or more analyte-binding molecules comprise haemoglobin, wherein the analyte comprises haptoglobin, b) adding citric acid, or citric acid and a citrate buffer, to the first mixture so as to adjust pH of the first mixture to be 3 or less, c) contacting a liquid reagent comprising a peroxidase substrate and a peroxide source with the first mixture to form a second mixture, while maintaining pH of the second mixture at 3 or less, d) quenching the second mixture to form a third mixture, e) optionally contacting the third mixture with a SERS-active substrate, and f) detecting a surface enhanced Raman signal from the third mixture and/or a surface of the SERS-active substrate. a) contacting one or more analyte-binding molecules with the analyte under conditions that allow binding of the analyte to the one or more analyte-binding molecules to form a first mixture, wherein the one or more analyte-binding molecules comprise haemoglobin, wherein the analyte comprises haptoglobin, b) adding citric acid, or citric acid and a citrate buffer, to the first mixture so as to adjust pH of the first mixture to be 3 or less, c) contacting a liquid reagent comprising a peroxidase substrate and a peroxide source with the first mixture to form a second mixture, while maintaining pH of the second mixture at 3 or less, d) quenching the second mixture to form a third mixture, e) optionally contacting the third mixture with a SERS-active substrate, and f) detecting a surface enhanced Raman signal from the third mixture and/or a surface of the SERS-active substrate.
An autofocus method based on object size implemented in a digital image acquisition apparatus, comprising: acquiring a digital image of a scene, wherein the scene includes one or more objects ; recognizing one or more objects based on pattern recognition ; determining one or more sizes of the recognized object(s) based on a pre-stored database ; calculating a distance to the recognized object(s) based on the determined size of the recognized object(s) ; adjusting a lens position based on the calculated distance , determining a contrast metric and performing fine search iteratively after the lens position is adjusted; adjusting a new lens position in each iteration until a contrast peak position is reached, wherein the pre-stored database comprises ground truth sizes, the ground truth sizes comprises mappings between objects and their respective size, characterized in that the ground truth sizes are set according to the lowest value or highest value in reality such that the direction of the fine search is set accordingly. acquiring a digital image of a scene, wherein the scene includes one or more objects ; recognizing one or more objects based on pattern recognition ; determining one or more sizes of the recognized object(s) based on a pre-stored database ; calculating a distance to the recognized object(s) based on the determined size of the recognized object(s) ; adjusting a lens position based on the calculated distance , determining a contrast metric and performing fine search iteratively after the lens position is adjusted; adjusting a new lens position in each iteration until a contrast peak position is reached, wherein the pre-stored database comprises ground truth sizes, the ground truth sizes comprises mappings between objects and their respective size, characterized in that the ground truth sizes are set according to the lowest value or highest value in reality such that the direction of the fine search is set accordingly.
A method of forming a fully clad interconnect, comprising: forming an opening in a dielectric layer, wherein said dielectric layer has a surface and said opening includes walls and a bottom; depositing a diffusion barrier layer on said dielectric layer surface, said walls and said bottom; depositing an adhesion layer on said diffusion barrier layer; depositing interconnect material on said adhesion layer; reflowing said interconnect material into said opening forming an interconnect in said opening, wherein said interconnect is recessed below said dielectric layer surface; depositing an adhesion capping layer over said interconnect; depositing a diffusion barrier capping layer over said adhesion capping layer, wherein said interconnect is surrounded by said adhesion layer and said adhesion capping layer, and said adhesion layer and said adhesion capping layer are surrounded by said diffusion barrier layer and said diffusion barrier capping layer, wherein the depositing a diffusion barrier layer and the depositing an adhesion layer comprise depositing two or more alternating layers of the adhesion and diffusion barrier layers at said bottom; and forming an air gap between the interconnect and a neighboring interconnect by partially removing the dielectric layer, wherein the dielectric layer remains below the interconnect and the neighboring interconnect. forming an opening in a dielectric layer, wherein said dielectric layer has a surface and said opening includes walls and a bottom; depositing a diffusion barrier layer on said dielectric layer surface, said walls and said bottom; depositing an adhesion layer on said diffusion barrier layer; depositing interconnect material on said adhesion layer; reflowing said interconnect material into said opening forming an interconnect in said opening, wherein said interconnect is recessed below said dielectric layer surface; depositing an adhesion capping layer over said interconnect; depositing a diffusion barrier capping layer over said adhesion capping layer, wherein said interconnect is surrounded by said adhesion layer and said adhesion capping layer, and said adhesion layer and said adhesion capping layer are surrounded by said diffusion barrier layer and said diffusion barrier capping layer, wherein the depositing a diffusion barrier layer and the depositing an adhesion layer comprise depositing two or more alternating layers of the adhesion and diffusion barrier layers at said bottom; and
A sack-shaped packaging means, which comprises a packaging material , which is arranged in at least two layers, wherein the packaging material comprises at least two layers (A, I), wherein a first layer comprises a non-woven fabric , wherein a second layer, which is connected in at least some regions to the non-woven fabric, comprises a plastic , characterized in that at least one monoaxially or biaxially stretched film web is provided as plastic, wherein the plastic is fastened integrally bonded to the non-woven fabric by means of a first connecting material, wherein the first connecting material is a polyolefin, in particular a polypropylene or polyethylene, wherein the packaging material comprises vent openings , wherein between 50 and 80 vent openings are provided per square centimeter, wherein each individual vent opening has a diameter of maximally 0.8 mm. which comprises a packaging material , which is arranged in at least two layers, wherein the packaging material comprises at least two layers (A, I), wherein a first layer comprises a non-woven fabric , wherein a second layer, which is connected in at least some regions to the non-woven fabric, comprises a plastic , characterized in that at least one monoaxially or biaxially stretched film web is provided as plastic, wherein the plastic is fastened integrally bonded to the non-woven fabric by means of a first connecting material, wherein the first connecting material is a polyolefin, in particular a polypropylene or polyethylene, wherein the packaging material comprises vent openings , wherein between 50 and 80 vent openings are provided per square centimeter, wherein each individual vent opening has a diameter of maximally 0.8 mm.
A power supply assembly , comprising: a drive device having an input side and an output side for providing power to a motor , the drive device including a bus capacitor ; a switch associated with the input side of the drive device for selectively connecting the input side of the drive device to a power supply ; and an inductor having an impedance that limits an amount of current supplied to the bus capacitor during an initial charging of the bus capacitor when the switch connects the input side of the drive device to the power supply ; characterized in that the power supply assembly comprises a restrictive circuit portion associated with the input side for dampening a resonance effect of the inductor , the restrictive circuit portion having a resistance that allows the bus capacitor to charge, the impedance of the inductor having a more significant effect on how quickly the bus capacitor charges than an effect of the resistance, a dampening factor of the restrictive circuit being based on a relationship between a capacitance of the bus capacitor , an inductance of the inductor and the resistance such that the dampening factor controls a voltage of the bus capacitor during the charging of the bus capacitor . a drive device having an input side and an output side for providing power to a motor , the drive device including a bus capacitor ; a switch associated with the input side of the drive device for selectively connecting the input side of the drive device to a power supply ; and an inductor having an impedance that limits an amount of current supplied to the bus capacitor during an initial charging of the bus capacitor when the switch connects the input side of the drive device to the power supply ; characterized in that the power supply assembly comprises a restrictive circuit portion associated with the input side for dampening a resonance effect of the inductor , the restrictive circuit portion having a resistance that allows the bus capacitor to charge, the impedance of the inductor having a more significant effect on how quickly the bus capacitor charges than an effect of the resistance, a dampening factor of the restrictive circuit being based on a relationship between a capacitance of the bus capacitor , an inductance of the inductor and the resistance such that the dampening factor controls a voltage of the bus capacitor during the charging of the bus capacitor .
Optical device , for a motor vehicle, such as a lighting or signalling device, this device comprising: - at least two light sources (2; 3) associated with different predetermined photometric functions, - a main light guide comprising an output face and arranged to guide the light originating from said light sources to this output face so that this output face defines a common lighting surface for the two photometric functions, wherein one of the photometric functions corresponds to a daytime lighting, and the other photometric function corresponds to a flashing direction indicator light, notably the light sources (2; 3) are arranged to emit lights of different colours; wherein one of the light sources is arranged to emit a white light associated with the daytime lighting photometric function and the other of the light sources is arranged to emit an amber coloured light associated with the flashing direction indicator light photometric function; and characterized in that it comprises an auxiliary light guide , notably produced in a single piece, arranged so as to guide the light from one of the light sources to the main light guide; and in that the output of the auxiliary guide or the main guide comprises a reflection zone which reflects the light radially in the main light guide. - at least two light sources (2; 3) associated with different predetermined photometric functions, - a main light guide comprising an output face and arranged to guide the light originating from said light sources to this output face so that this output face defines a common lighting surface for the two photometric functions,
Filter assembly for a laundry treatment appliance , comprising a filter receptacle , a filter , a flap which is pivotable about a pivot axis , and a locking device having a locking part which is preloaded by means of a spring of the locking device , it being possible for the filter to be transferred back and forth between a receiving position, in which the filter is received in the filter receptacle , and a removal position, in which the filter is removed from the filter receptacle , and it being possible for the flap to be transferred back and forth along an actuating path between a closed position, in which the flap covers the filter receptacle such that the flap forms an optical unit with the remainder of the laundry treatment appliance and/or allows the laundry treatment appliance to be started up, and an open position, in which the flap uncovers the filter receptacle , and it being possible for the locking part of the locking device to be transferred back and forth between a locked position, in which the locking part prevents the flap from being transferred into its closed position, and a release position, in which the locking part allows the flap to be transferred into its closed position, namely such that the spring preloads the locking part in the direction of its locked position and the locking part can be transferred in the direction of its release position by means of the filter against a spring force of the spring and can be held in the release position, characterized in that the locking part is designed as a slide which is movably mounted in a slide guide of the filter assembly , which guide extends transversely to the actuating path of the flap , such that the locking part is aligned transversely to the pivot axis, the slide guide having a first end stop for the slide , which corresponds to the locked position, and a second end stop for the slide , which corresponds to the release position.
An assisting apparatus comprising: a base capable of moving with a care receiver placed on the base ; characterized by: an elevator that is supported by the base in a vertically movable manner and supplied with power by a battery power supply; a pivot member that is supported by the elevator in a pivotable manner; a holder that is supported by the pivot member and holds an upper body of the care receiver, and by pivoting forward from a sitting posture, puts the care receiver into a transferring posture; a first handle portion , being provided on the pivot member or the holder , which is arranged on a front of the holder in the transferring posture; and a second handle portion , being provided on the pivot member or the holder , which is arranged on an underside of the holder in the transferring posture. a base capable of moving with a care receiver placed on the base ; characterized by: an elevator that is supported by the base in a vertically movable manner and supplied with power by a battery power supply; a pivot member that is supported by the elevator in a pivotable manner; a holder that is supported by the pivot member and holds an upper body of the care receiver, and by pivoting forward from a sitting posture, puts the care receiver into a transferring posture; a first handle portion , being provided on the pivot member or the holder , which is arranged on a front of the holder in the transferring posture; and a second handle portion , being provided on the pivot member or the holder , which is arranged on an underside of the holder in the transferring posture. an elevator that is supported by the base in a vertically movable manner and supplied with power by a battery power supply; a pivot member that is supported by the elevator in a pivotable manner; a holder that is supported by the pivot member and holds an upper body of the care receiver, and by pivoting forward from a sitting posture, puts the care receiver into a transferring posture; a first handle portion , being provided on the pivot member or the holder , which is arranged on a front of the holder in the transferring posture; and a second handle portion , being provided on the pivot member or the holder , which is arranged on an underside of the holder in the transferring posture.
A cleaner , comprising a hand-held device , wherein the hand-held device comprises: a housing defining an air inlet , an air outlet and an air blowing port therein, the air blowing port being disposed adjacent to the air inlet and obliquely extending towards the air inlet ; a dust cup disposed in the housing and connected with the air inlet ; and an electric motor defining a motor chamber , the motor chamber being communicated with the dust cup ; wherein an air blowing channel is provided in the housing , and the air blowing channel has a first end communicating with the motor chamber and a second end provided with the air blowing port , the air blowing channel extends in a front and rear direction; wherein an airflow entering through the air inlet switchably flows out of one of the air outlet and the air blowing port by a switching mechanism after flowing through the dust cup and the electric motor , wherein the switching mechanism is configured to be movable in a substantially horizontal direction between a communicating position for communicating the air blowing port with the motor chamber and a partitioning position for partitioning the air blowing port from the motor chamber , the switching mechanism is located at an upper portion of the cleaner , and the air blowing channel has a cross sectional area gradually decreasing along a flowing direction of the airflow. a housing defining an air inlet , an air outlet and an air blowing port therein, the air blowing port being disposed adjacent to the air inlet and obliquely extending towards the air inlet ; a dust cup disposed in the housing and connected with the air inlet ; and an electric motor defining a motor chamber , the motor chamber being communicated with the dust cup ; wherein an air blowing channel is provided in the housing , and the air blowing channel has a first end communicating with the motor chamber and a second end provided with the air blowing port , the air blowing channel extends in a front and rear direction; wherein an airflow entering through the air inlet switchably flows out of one of the air outlet and the air blowing port by a switching mechanism after flowing through the dust cup and the electric motor , wherein the switching mechanism is configured to be movable in a substantially horizontal direction between a communicating position for communicating the air blowing port with the motor chamber and a partitioning position for partitioning the air blowing port from the motor chamber , the switching mechanism is located at an upper portion of the cleaner , and the air blowing channel has a cross sectional area gradually decreasing along a flowing direction of the airflow.
A compound or optical isomers or solvates or pharmaceutically acceptable salts hereof, (a) where the compound has a structure of formula (I), wherein R 1 is selected from unsubstituted pyridyl, trifluoromethyl, -Br, and phenyl substituted with one or more substituents selected from methoxy and ethoxy; R 2 and R 3 are both methyl or both ethyl; and R 4 is a hydrogen atom; or (b) where the compound has a structure of (a) where the compound has a structure of formula (I), wherein R 1 is selected from unsubstituted pyridyl, trifluoromethyl, -Br, and phenyl substituted with one or more substituents selected from methoxy and ethoxy; R 2 and R 3 are both methyl or both ethyl; and R 4 is a hydrogen atom; or wherein R 1 is selected from unsubstituted pyridyl, trifluoromethyl, -Br, and phenyl substituted with one or more substituents selected from methoxy and ethoxy; R 2 and R 3 are both methyl or both ethyl; and R 4 is a hydrogen atom; or (b) where the compound has a structure of
A gap junction inhibitor for use in treating a subject having a cancer, wherein administration of the gap junction inhibitor inhibits metastatic progression of the cancer in the brain of the subject.
A system, comprising: a first memory server, comprising: a cache-coherent switch , and a first memory module; and a second memory server; and a server-linking switch connected to the first memory server and to the second memory server, wherein: the first memory module is connected to the cache-coherent switch , and the cache-coherent switch is connected to the server-linking switch, characterised in that the server-linking switch is configured to disable power to the first memory module. a first memory server, comprising: a cache-coherent switch , and a first memory module; and a cache-coherent switch , and a first memory module; and a second memory server; and a server-linking switch connected to the first memory server and to the second memory server, wherein: the first memory module is connected to the cache-coherent switch , and the cache-coherent switch is connected to the server-linking switch, characterised in that the server-linking switch is configured to disable power to the first memory module. the first memory module is connected to the cache-coherent switch , and the cache-coherent switch is connected to the server-linking switch, characterised in that the server-linking switch is configured to disable power to the first memory module.