mhurhangee/patent-ind-claim-en huggingface dataset:
An implantable sensor for implantation in a vessel, comprising: a plurality of pairs of electrodes for placement on, in or adjacent a vessel wall; means for selecting at least one pair of electrodes from the plurality of pairs of electrodes to which drive signals are to be delivered; means for providing a drive signal to the at least one selected pair of electrodes; means for measuring at least one of impedance and capacitance between the electrodes in the at least one selected pair of electrodes; and means for wirelessly communicating data from the sensor; characterized in that the plurality of pairs of electrodes are comprised in a circumferential array of electrodes, wherein the electrodes are disposed at a predetermined circumferential spacing from each other. a plurality of pairs of electrodes for placement on, in or adjacent a vessel wall; means for selecting at least one pair of electrodes from the plurality of pairs of electrodes to which drive signals are to be delivered; means for providing a drive signal to the at least one selected pair of electrodes; means for measuring at least one of impedance and capacitance between the electrodes in the at least one selected pair of electrodes; and means for wirelessly communicating data from the sensor; characterized in that the plurality of pairs of electrodes are comprised in a circumferential array of electrodes, wherein the electrodes are disposed at a predetermined circumferential spacing from each other.
An indoor unit for an air-conditioning apparatus, comprising: a casing having an air inlet and an air outlet ; an up-down airflow direction plate configured to be rotatably supported in the air outlet ; and an auxiliary airflow direction plate configured to be rotatably supported at a position below the up-down airflow direction plate and on an upstream side of the up-down airflow direction plate , the up-down airflow direction plate having a main blade part formed of a flat plate, and a rear edge part formed of a flat plate and formed on an upstream side of the main blade part , when the main blade part is in a horizontal state, the rear edge part being inclined upward to a back face of the casing from the main blade part , when an angle α represents an angle formed between the main blade part and the rear edge part and an angle ε represents an angle formed between the main blade part and a virtual line (D) passing through a center of a tip part of the auxiliary airflow direction plate , the angle ε being greater than the angle α characterized in that the angle α is in a range from 130 to 165 degrees. a casing having an air inlet and an air outlet ; an up-down airflow direction plate configured to be rotatably supported in the air outlet ; and an auxiliary airflow direction plate configured to be rotatably supported at a position below the up-down airflow direction plate and on an upstream side of the up-down airflow direction plate , the up-down airflow direction plate having a main blade part formed of a flat plate, and a rear edge part formed of a flat plate and formed on an upstream side of the main blade part , when the main blade part is in a horizontal state, the rear edge part being inclined upward to a back face of the casing from the main blade part , when an angle α represents an angle formed between the main blade part and the rear edge part and an angle ε represents an angle formed between the main blade part and a virtual line (D) passing through a center of a tip part of the auxiliary airflow direction plate , the angle ε being greater than the angle α characterized in that the angle α is in a range from 130 to 165 degrees.
A nucleic acid molecule for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule consists of a single guide region corresponding to one of the two hairpin structures of the wild type H/ACA snoRNA, wherein the nucleic acid molecule is capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.
A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a select time period within the 24 hour time period when the same gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; wherein the gene that is variably expressed in native untreated skin cells is one or more of Period gene 1, 2, or 3 (PERI, 2, 3); Circadian Locomotor Output Cycles Kaput (CLOCK) gene; Brain and Muscle Arylhydrocarbon Receptor Nuclear Translocator (BMAL) gene; or cryptochrome circadian gene (CRY); and wherein the at least one ingredient that stimulates CLOCK, PER, CRY, or BMAL is one or more of: cichoric acid, Echinacea extract, Tripeptide-32, Tetrapeptide-26; or an autophagy activator selected from yeast extracts from the genuses Candida or Yarrowia ; wherein the sheet pack is in the form of a laminate with an impermeable layer bonded to the absorbent layer with a bonding agent; wherein the bonding agent has a melting point ranging from 200 to 300 °C; wherein the laminate has a thickness ranging from 0.2 to 1.5 mm; wherein the absorbent layer is a non-woven fabric and the impermeable layer is a metallic foil; and wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 18:00 to 24:00 hours.
Plant belonging to the Solanaceae family wherein said plant comprises a genetic trait providing Phytophthora resistance and wherein said a genetic trait providing Phytophthora resistance is encoded by a combination of at least two genes having a reduced expression, or transcription, of said two genes as compared to said plant belonging to Solanaceae family being susceptible to Phytophthora wherein: said plant is sweet pepper ( Capsicum annuum ) or Capsicum spp., said Phytophthora resistance is resistance to Phytophthora capsici and said combination of at least two genes are genes encoding proteins according to SEQ ID No. 16 and SEQ ID No. 17, or proteins having at least 90% sequence identity with SEQ ID Nos. 16 and 17.
An oral care implement comprising a head and a handle , the head being repeatedly attachable to and detachable from the handle , the head being made from a non-magnetic and/or non-ferromagnetic material, and the handle being made at least partially made from a magnetic and/or ferromagnetic material, characterized in that the magnetic and/or ferromagnetic material comprises from about 13 weight percent to about 30 weight percent of an amorphous thermoplastic resin; from about 3 weight percent to about 25 weight percent of aluminum oxide, boron nitride or aluminum silicate; and from about 45 weight percent to about 67 weight percent of iron oxide.
Method for improving the flight characteristics of a multicopter in a failure situation, wherein the multicopter comprises at least six rotors, each with a defined nominal rotational direction and control electronics with a stored control program, the method comprising: • actuation of the rotors with the control electronics in such a way that they rotate according to their respective nominal rotational direction, and • in the failure situation, actuation of at least one of the remaining rotors with the control electronics in such a way that said rotor rotates at least temporarily counter to its nominal rotational direction. • actuation of the rotors with the control electronics in such a way that they rotate according to their respective nominal rotational direction, and • in the failure situation, actuation of at least one of the remaining rotors with the control electronics in such a way that said rotor rotates at least temporarily counter to its nominal rotational direction.
A tool comprising: one or more jaws ; a hydraulic actuator cylinder ; a piston slidably accommodated within the hydraulic actuator cylinder , wherein the piston includes a piston head and a piston rod extending from the piston head along a central axis direction of the hydraulic actuator cylinder , wherein the piston head divides an inside of the hydraulic actuator cylinder into a first chamber and a second chamber , wherein the piston is partially hollow, and wherein the piston rod is disposed in the first chamber and configured to move the one or more jaws of the tool; a pump configured to provide pressurized fluid; a high pressure check valve ; and a sequence valve configured to block the pressurized fluid from flowing into the second chamber of the hydraulic actuator cylinder until pressure of the pressurized fluid exceeds a threshold pressure value, wherein when the tool is triggered: the pump provides the pressurized fluid to a hollow portion of the piston , causing the piston to extend at a first speed until at least one of the one or more jaws reach an object placed therebetween, and thereafter, pressure of the pressurized fluid increases until the pressure reaches the threshold pressure value, causing the sequence valve to open providing a path for the pressurized fluid to the second chamber , causing the piston to extend at a second speed; and the tool being characterised in that the high pressure check valve is configured to prevent the pressurized fluid from flowing into the second chamber as the piston extends at the first speed. one or more jaws ; a hydraulic actuator cylinder ; a piston slidably accommodated within the hydraulic actuator cylinder , wherein the piston includes a piston head and a piston rod extending from the piston head along a central axis direction of the hydraulic actuator cylinder , wherein the piston head divides an inside of the hydraulic actuator cylinder into a first chamber and a second chamber , wherein the piston is partially hollow, and wherein the piston rod is disposed in the first chamber and configured to move the one or more jaws of the tool; a pump configured to provide pressurized fluid; a high pressure check valve ; and a sequence valve configured to block the pressurized fluid from flowing into the second chamber of the hydraulic actuator cylinder until pressure of the pressurized fluid exceeds a threshold pressure value, wherein when the tool is triggered: the pump provides the pressurized fluid to a hollow portion of the piston , causing the piston to extend at a first speed until at least one of the one or more jaws reach an object placed therebetween, and thereafter, pressure of the pressurized fluid increases until the pressure reaches the threshold pressure value, causing the sequence valve to open providing a path for the pressurized fluid to the second chamber , causing the piston to extend at a second speed; and the tool being characterised in that the high pressure check valve is configured to prevent the pressurized fluid from flowing into the second chamber as the piston extends at the first speed.
A method for producing heating in a high temperature heat pump apparatus having a heat exchanger comprising extracting heat from a working fluid, thereby producing a cooled working fluid wherein said working fluid comprises -1,1,1,4,5,5,5-heptafluoro-4-(trifluoromethyl)pent-2-ene; wherein the heat exchanger operates at a temperature of at least 55°C.
A lubricating oil composition for an automatic transmission including: as low-viscosity base oils: (i) between 45 and 95 mass% of a Fischer-Tropsch synthetic low-viscosity base oil with a 100°C kinematic viscosity of between 1 mm 2 /s and 2 mm 2 /s, and between 0 and 25 mass% of other than a Fischer-Tropsch synthetic low-viscosity base oil with a 100°C kinematic viscosity of between 1 mm 2 /s and 2 mm 2 /s, and (ii) between 0 and 35 mass% of a base oil wherein the 100°C kinematic viscosity is greater that 2 mm 2 /s and no greater than 5 mm 2 /s; and (iii) between 5 and 55 mass% of an olefin polymer or co-polymer, as a high-viscosity base oil, wherein the 100°C kinematic viscosity is between 100 and 800 mm 2 /s, wherein: the 100°C kinematic viscosity of the composition is between 3.8 and 5.5 mm 2 /s, the viscosity index is no less than 190, the flashpoint is no less than 140°C, and the reduction ratio in the 100°C kinematic viscosity after KRL shear stability testing, at 60°C for 20 hours, according to CEC-L-45-A-99, is no greater than 3%.
A carbon black for batteries, the carbon black having a BET specific surface area measured according to JIS K6217-2 C method of 100 m 2 /g or larger, and a surface fluorine concentration X (unit: atom%) and a surface oxygen concentration Y (unit: atom%) measured by X-ray Photoelectron Spectroscopy (XPS) satisfying the following conditions (A) and (B), (A) 0.3≤X≤4.0 and (B) 0.1 Y≤3.0. (A) 0.3≤X≤4.0 and (B) 0.1 Y≤3.0.
A sensor controller for use in a position detector for detecting a position of a position indicator on a touch surface , comprising: a controller which is configured to output a value of a symbol to be sent to the position indicator; and a transmitter coupled to the controller, characterised in that the transmitter is configured to generate a transmission signal including a first chip string (CN1) produced by cyclically shifting a spread code (PN) having autocorrelation characteristics by a shift quantity (SA) based on the value of the symbol to be sent, and to send the generated transmission signal to the position indicator via the touch surface , wherein the symbol takes multiple values, and the transmitter is configured to generate the transmission signal representing any one of the multiple values based on the shift quantity (SA) and non-inversion and inversion of the spread code (PN). a controller which is configured to output a value of a symbol to be sent to the position indicator; and a transmitter coupled to the controller, characterised in that the transmitter is configured to generate a transmission signal including a first chip string (CN1) produced by cyclically shifting a spread code (PN) having autocorrelation characteristics by a shift quantity (SA) based on the value of the symbol to be sent, and to send the generated transmission signal to the position indicator via the touch surface , wherein the symbol takes multiple values, and the transmitter is configured to generate the transmission signal representing any one of the multiple values based on the shift quantity (SA) and non-inversion and inversion of the spread code (PN).
A system for manipulating tissue, comprising: a grasper configured to be attached to tissue in a body of a patient, wherein the grasper comprises two arms having an open configuration and a closed configuration, wherein the arms are configured to attach to tissue by holding the tissue between two surfaces in the closed configuration, and wherein the two arms are connected via a linkage assembly having an expanded configuration and a collapsed configuration and comprising a plurality of struts and a plurality of pivot joints , a delivery device configured to releasably engage the grasper and to actuate the grasper between a first configuration and a second configuration; wherein the linkage assembly is connected to a coupling element , and wherein the two arms can be moved from the closed configuration to the open configuration by distally advancing an actuation rod within a lumen of the delivery device , and releasably engaging the actuation rod with the coupling element ; and moving the linkage assembly out of the lumen ; and a magnetic control assembly comprising a magnet configured to generate a magnetic field and to apply a magnetic force to the grasper. a grasper configured to be attached to tissue in a body of a patient, wherein the grasper comprises two arms having an open configuration and a closed configuration, wherein the arms are configured to attach to tissue by holding the tissue between two surfaces in the closed configuration, and wherein the two arms are connected via a linkage assembly having an expanded configuration and a collapsed configuration and comprising a plurality of struts and a plurality of pivot joints , a delivery device configured to releasably engage the grasper and to actuate the grasper between a first configuration and a second configuration; wherein the linkage assembly is connected to a coupling element , and wherein the two arms can be moved from the closed configuration to the open configuration by distally advancing an actuation rod within a lumen of the delivery device , and releasably engaging the actuation rod with the coupling element ; and moving the linkage assembly out of the lumen ; and a magnetic control assembly comprising a magnet configured to generate a magnetic field and to apply a magnetic force to the grasper.
A pharmaceutical composition comprising an oritavancin drug substance preparation and one or more pharmaceutically acceptable excipients, wherein the oritavancin drug substance preparation has a maximum impurity level of not more than 3.0% by peak area of impurity 1 (oritavancin factor A) and impurity 7 (oritavancin factor C), wherein oritavancin factor A has the structure and oritavancin factor C has the structure and wherein the purity level of the oritavancin drug substance preparation is measured by HPLC.
A composition for inhibiting monomer polymerization comprising: an inhibitor compound that comprises an N-to-O bond, wherein the inhibitor compound is selected from the group consisting of nitroxide-, amine oxide-, hydroxylamine-, nitroso-, and nitrone-containing compounds; a retarder compound that is a quinone methide; and a stabilizer compound comprising a primary amine group of formula R 1 NH 2 , wherein R 1 is a linear, branched, or cyclic alkyl group of 4 - 24 carbons. an inhibitor compound that comprises an N-to-O bond, wherein the inhibitor compound is selected from the group consisting of nitroxide-, amine oxide-, hydroxylamine-, nitroso-, and nitrone-containing compounds; a retarder compound that is a quinone methide; and a stabilizer compound comprising a primary amine group of formula R 1 NH 2 , wherein R 1 is a linear, branched, or cyclic alkyl group of 4 - 24 carbons.
A method of wireless communication by a user equipment, UE, the method characterized by : determining whether to indicate a beam failure recovery request to a base station using a contention-free random access channel, RACH, procedure with a dedicated preamble when the UE is timing unsynchronized with the base station; performing , when the UE is timing unsynchronized with the base station, the contention-free RACH procedure with the dedicated preamble to indicate the beam failure recovery request when the beam failure recovery request is determined to be indicated to the base station using the contention-free RACH procedure with the dedicated preamble; and performing , when the UE is timing unsynchronized with the base station, a contention-based RACH procedure to indicate the beam failure recovery request when the beam failure recovery request is determined not to be sent to the base station using the contention-free RACH procedure with the dedicated preamble. determining whether to indicate a beam failure recovery request to a base station using a contention-free random access channel, RACH, procedure with a dedicated preamble when the UE is timing unsynchronized with the base station; performing , when the UE is timing unsynchronized with the base station, the contention-free RACH procedure with the dedicated preamble to indicate the beam failure recovery request when the beam failure recovery request is determined to be indicated to the base station using the contention-free RACH procedure with the dedicated preamble; and performing , when the UE is timing unsynchronized with the base station, a contention-based RACH procedure to indicate the beam failure recovery request when the beam failure recovery request is determined not to be sent to the base station using the contention-free RACH procedure with the dedicated preamble.
A method for producing hypromellose phthalate, the method comprising: an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate; a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension; a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate; and a drying step of drying the liquid-removed hypromellose phthalate. an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate; a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension; a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate; and a drying step of drying the liquid-removed hypromellose phthalate.
An antagonist of the BTLA/HVEM interaction for use in therapy, wherein said antagonist increases the proliferation of Vγ9Vδ2 T cells, wherein said antagonist is a monoclonal antibody directed against HVEM or a fragment thereof which blocks the interaction between BTLA and HVEM, wherein said monoclonal antibody or said fragment thereof comprises: - all the CDRs of the variable light chain (VL) chain of the antibody obtainable from hybridoma deposited as CNCM 1-4752; and - all the CDRs of the variable heavy chain (VH) chain of the antibody obtainable from hybridoma deposited as CNCM 1-4752. - all the CDRs of the variable light chain (VL) chain of the antibody obtainable from hybridoma deposited as CNCM 1-4752; and - all the CDRs of the variable heavy chain (VH) chain of the antibody obtainable from hybridoma deposited as CNCM 1-4752.
A method of providing a measure of tumor mutation burden in a test sample of cell-free nucleic acids from a subject having a cancer type or signs of a cancer type, comprising: (a) determining, by a computer, a number of mutations present in the test sample of cell-free nucleic acids, and a minor allele fraction based on one or more mutations most highly represented in the test sample of cell-free nucleic acids; and (b) normalizing, by a computer, the number of mutations present in the sample to a number of mutations present in control samples from other subjects with the same cancer type and a minor allele fraction within a bin of minor allele fractions including the minor allele fraction of the test sample to determine a measure of cancer mutation burden in the test sample. (a) determining, by a computer, a number of mutations present in the test sample of cell-free nucleic acids, and a minor allele fraction based on one or more mutations most highly represented in the test sample of cell-free nucleic acids; and (b) normalizing, by a computer, the number of mutations present in the sample to a number of mutations present in control samples from other subjects with the same cancer type and a minor allele fraction within a bin of minor allele fractions including the minor allele fraction of the test sample to determine a measure of cancer mutation burden in the test sample.