A compound of formula I wherein R1 represents 1 to 3 identical or different R1 substituents, wherein said R1 is independently at each occurrence selected from hydrogen, halogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxyalkyl and C 1 -C 8 alkoxyalkyl, wherein preferably R1 represents 1 or 2 R1 substituents, and further preferably R1 represents 1 R1 substituent; Ra is selected from phenyl, pyridinyl, pyrimidinyl, thiazolyl, thiodiazolyl, oxazolyl, pyrazolyl and triazolyl wherein said phenyl, pyridinyl, thiazolyl, thiodiazolyl, oxazolyl, pyrazolyl and triazolyl is independently optionally substituted by one or more substituents independently selected from halogen, hydroxyl, cycloalkyl, C 1 -C 4 alkyl-substituted cycloalkyl, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 alkylaminocarbonyl, C 1 -Cshydroxyalkyl, C 1 -C 8 haloalkoxy, C 1 -C 8 dialkylaminoC 1 -C 8 alkyl, C 1 -C 8 aminoalkyl and a heterocycle selected from oxiran, oxetane, aziridine and azetidine wherein said oxiran, oxetane, aziridine and azetidine are independently optionally substituted by halogen, hydroxyl, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, C 1 -C 2 alkoxy; or Ra is -CONHR' wherein R' is selected from C 1 -C 8 alkyl, cycloalkyl, aryl, heteroaryl and C 1 -C 8 alkyl-N-morpholino, wherein said aryl, heteroaryl and C 1 -C 8 alkyl-N-morpholino is independently optionally substituted by [one or more] substituents selected from halogen, cycloalkyl, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxalkyl and C 1 -C 8 alkoxyalkyl; Ar/Het is selected from pyridinyl, phenyl and oxazolyl wherein said pyridinyl, phenyl and oxazolyl is independently optionally substituted by one or more substituents independently selected from halogen, cyano, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxyalkyl and C 1 -C 8 alkoxyalkyl; or pharmaceutically acceptable salt, or hydrate thereof. R1 represents 1 to 3 identical or different R1 substituents, wherein said R1 is independently at each occurrence selected from hydrogen, halogen, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxyalkyl and C 1 -C 8 alkoxyalkyl, wherein preferably R1 represents 1 or 2 R1 substituents, and further preferably R1 represents 1 R1 substituent; Ra is selected from phenyl, pyridinyl, pyrimidinyl, thiazolyl, thiodiazolyl, oxazolyl, pyrazolyl and triazolyl wherein said phenyl, pyridinyl, thiazolyl, thiodiazolyl, oxazolyl, pyrazolyl and triazolyl is independently optionally substituted by one or more substituents independently selected from halogen, hydroxyl, cycloalkyl, C 1 -C 4 alkyl-substituted cycloalkyl, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 alkylaminocarbonyl, C 1 -Cshydroxyalkyl, C 1 -C 8 haloalkoxy, C 1 -C 8 dialkylaminoC 1 -C 8 alkyl, C 1 -C 8 aminoalkyl and a heterocycle selected from oxiran, oxetane, aziridine and azetidine wherein said oxiran, oxetane, aziridine and azetidine are independently optionally substituted by halogen, hydroxyl, C 1 -C 2 alkyl, C 1 -C 2 haloalkyl, C 1 -C 2 alkoxy; or Ra is -CONHR' wherein R' is selected from C 1 -C 8 alkyl, cycloalkyl, aryl, heteroaryl and C 1 -C 8 alkyl-N-morpholino, wherein said aryl, heteroaryl and C 1 -C 8 alkyl-N-morpholino is independently optionally substituted by [one or more] substituents selected from halogen, cycloalkyl, C 1 -C 8 alkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxalkyl and C 1 -C 8 alkoxyalkyl; Ar/Het is selected from pyridinyl, phenyl and oxazolyl wherein said pyridinyl, phenyl and oxazolyl is independently optionally substituted by one or more substituents independently selected from halogen, cyano, C 1 -C 8 alkyl, C 1 -C 8 haloalkyl, C 1 -C 8 alkoxy, C 1 -C 8 hydroxyalkyl and C 1 -C 8 alkoxyalkyl; or pharmaceutically acceptable salt, or hydrate thereof. <EOS>