mhurhangee/patent-ind-claim-en huggingface dataset:
An anti-IL-12/IL-23p40 antibody for use in a method of treating moderately to severely active ulcerative colitis (UC) in a human subject in need thereof, wherein the antibody comprises a heavy chain variable region of the amino acid sequence of SEQ ID NO:7 and a light chain variable region of the amino acid sequence of SEQ ID NO:8, wherein the method comprises: a. intravenously administering to the subject the antibody in a first pharmaceutical composition at week 0 of the treatment at a dosage of 260 mg for subjects with body weight ≥35 kg and ≤55 kg, 390 mg for subjects with body weight >55 kg and ≤85 kg, and 520 mg for subjects with body weight >85 kg, and b. subcutaneously administering to the subject the antibody in a second pharmaceutical composition at a dosage of 90 mg per administration, at week 8 of the treatment, and in a maintenance dose every 8 weeks or every 12 weeks after the treatment at week 8, wherein the subject is in corticosteroid-free clinical remission at least 44 weeks after week 0. wherein the antibody comprises a heavy chain variable region of the amino acid sequence of SEQ ID NO:7 and a light chain variable region of the amino acid sequence of SEQ ID NO:8, wherein the method comprises: a. intravenously administering to the subject the antibody in a first pharmaceutical composition at week 0 of the treatment at a dosage of 260 mg for subjects with body weight ≥35 kg and ≤55 kg, 390 mg for subjects with body weight >55 kg and ≤85 kg, and 520 mg for subjects with body weight >85 kg, and b. subcutaneously administering to the subject the antibody in a second pharmaceutical composition at a dosage of 90 mg per administration, at week 8 of the treatment, and in a maintenance dose every 8 weeks or every 12 weeks after the treatment at week 8, wherein the subject is in corticosteroid-free clinical remission at least 44 weeks after week 0. a. intravenously administering to the subject the antibody in a first pharmaceutical composition at week 0 of the treatment at a dosage of 260 mg for subjects with body weight ≥35 kg and ≤55 kg, 390 mg for subjects with body weight >55 kg and ≤85 kg, and 520 mg for subjects with body weight >85 kg, and b. subcutaneously administering to the subject the antibody in a second pharmaceutical composition at a dosage of 90 mg per administration, at week 8 of the treatment, and in a maintenance dose every 8 weeks or every 12 weeks after the treatment at week 8, wherein the subject is in corticosteroid-free clinical remission at least 44 weeks after week 0.
Electronic device for adjusting a thermo-fluidic system for a building , said thermo-fluidic system comprising a heating/cooling system (50, 54; 80, 82, 84, 85) including mixing valves adapted to control flows of hot/cold water within said heating/cooling system (50, 54; 80, 82, 84, 85), said device comprising a control unit adapted to: - receive a predefined reference signal representative of a desired parameter for the building ; - receive environmental signals from environmental sensors arranged in the building and adapted to measure environmental parameters of said building ; - issue a control signal towards an actuator associated with a respective mixing valve in order to control the opening or closing thereof, said electronic device being characterized in that it is further adapted to receive a main signal from a building management system and is installed upstream of said actuator between the cable that carries said main signal and the actuator itself, and in that said control unit comprises: - a sum block for computing an error signal (e(t)) between said reference signal and one of said environmental signal ; - a derivative block for deriving an error first derivative signal (de(t) / dt) of said error signal ( e(t) ) ; - a fuzzy controller block for applying a fuzzy algorithm in order to compare said main signal with said error (e(t)) and error first derivative (d e(t) /d t) signals, so as to obtain said control signal . - receive a predefined reference signal representative of a desired parameter for the building ; - receive environmental signals from environmental sensors arranged in the building and adapted to measure environmental parameters of said building ; - issue a control signal towards an actuator associated with a respective mixing valve in order to control the opening or closing thereof, - a sum block for computing an error signal (e(t)) between said reference signal and one of said environmental signal ; - a derivative block for deriving an error first derivative signal (de(t) / dt) of said error signal ( e(t) ) ; - a fuzzy controller block for applying a fuzzy algorithm in order to compare said main signal with said error (e(t)) and error first derivative (d e(t) /d t) signals, so as to obtain said control signal .
A coating blade for application of coating color to a fibrous web , the coating blade comprising an elongate substrate having a longitudinal edge, wherein, within an operating zone, intended for contact with a coating color, of the coating blade, the substrate is provided with: a longitudinal wear-resistant deposit adjacent to the longitudinal edge; and a longitudinal masking deposit arranged on the substrate next to and joining the longitudinal wear-resistant deposit, wherein the masking deposit has a lower elastic modulus than the substrate and wherein the transition between the surface intended for contact with the coating color of the wear-resistant deposit and the surface intended for contact with the coating color of the masking deposit is substantially flush. a longitudinal wear-resistant deposit adjacent to the longitudinal edge; and a longitudinal masking deposit arranged on the substrate next to and joining the longitudinal wear-resistant deposit, wherein the masking deposit has a lower elastic modulus than the substrate and
Method for the contactless determination of the velocity distribution of the liquid flow (v) of a liquid metal in a continuous casting die during slab casting, wherein - the continuous casting die has a wide side and a narrow side, - a single primary magnetic field (bo), running along the vertical direction, is generated in the liquid flow in the continuous casting die, - the magnetic fields (b) induced by the interaction of the liquid flow with the primary magnetic field (bo) are measured at a plurality of recording points outside the liquid flow, wherein the induced magnetic fields are only measured on the narrow side of the continuous casting die, and - the measured induced magnetic fields (b) are used to determine the two velocity components of the liquid flow (v) directed parallel to the wide side of the continuous casting die. - the continuous casting die has a wide side and a narrow side, - a single primary magnetic field (bo), running along the vertical direction, is generated in the liquid flow in the continuous casting die, - the magnetic fields (b) induced by the interaction of the liquid flow with the primary magnetic field (bo) are measured at a plurality of recording points outside the liquid flow, wherein the induced magnetic fields are only measured on the narrow side of the continuous casting die, and - the measured induced magnetic fields (b) are used to determine the two velocity components of the liquid flow (v) directed parallel to the wide side of the continuous casting die.
An infusion system comprising: a pump ; a fluid delivery line connected to the pump for delivering fluid; at least one sensor connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line ; a processor in electronic communication with the pump and the at least one sensor ; and a memory in electronic communication with the processor , wherein the memory comprises programming code for execution by the processor so that the processor is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the at least one sensor , characterized in that the processor is configured to determine if the stuck fluid droplet is stuck within the fluid delivery line at the location of the at least one sensor by determining a pattern relationship over time between a plurality of digital measurements of the signals, and determine that the stuck fluid droplet is present if the determined pattern relationship starts at or below a known liquid signal ADC value at a first period in time, increases from at or below the known liquid signal ADC value over a primary threshold ADC value at a second period in time, decreases from over the primary threshold ADC value to between the primary threshold ADC value and a secondary threshold ADC value at a third period in time, and passes a stability test while being disposed at a fourth period in time between the primary threshold ADC value and the secondary threshold ADC value. a pump ; a fluid delivery line connected to the pump for delivering fluid; at least one sensor connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line ; a processor in electronic communication with the pump and the at least one sensor ; and a memory in electronic communication with the processor , wherein the memory comprises programming code for execution by the processor so that the processor is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the at least one sensor , characterized in that the processor is configured to determine if the stuck fluid droplet is stuck within the fluid delivery line at the location of the at least one sensor by determining a pattern relationship over time between a plurality of digital measurements of the signals, and determine that the stuck fluid droplet is present if the determined pattern relationship starts at or below a known liquid signal ADC value at a first period in time, increases from at or below the known liquid signal ADC value over a primary threshold ADC value at a second period in time, decreases from over the primary threshold ADC value to between the primary threshold ADC value and a secondary threshold ADC value at a third period in time, and passes a stability test while being disposed at a fourth period in time between the primary threshold ADC value and the secondary threshold ADC value.
A method for a crane comprising: receiving angle feedback information on a hoisting rope angle of a crane, the angle feedback information being measured from the hoisting rope by means of a sensor at or adjacent to a trolley of the crane; correcting the received angle feedback information by compensating, using results obtained via a feedback loop comprising at least preceding angle feedback information measured by the sensor from the hoisting rope, an error caused by a speed change, and processing the corrected angle feedback information to provide movement instructions or other control information relating to the crane, and being racterized in that the processing comprises inputting the corrected angle feedback information to a dead zone unit , modifying the corrected angle feedback information by the dead zone unit , outputting modified signal by the dead zone unit and multiplying the modified signal by a gain to obtain a first reference speed for the crane. receiving angle feedback information on a hoisting rope angle of a crane, the angle feedback information being measured from the hoisting rope by means of a sensor at or adjacent to a trolley of the crane; correcting the received angle feedback information by compensating, using results obtained via a feedback loop comprising at least preceding angle feedback information measured by the sensor from the hoisting rope, an error caused by a speed change, and processing the corrected angle feedback information to provide movement instructions or other control information relating to the crane, and being racterized in that the processing comprises inputting the corrected angle feedback information to a dead zone unit , modifying the corrected angle feedback information by the dead zone unit , outputting modified signal by the dead zone unit and multiplying the modified signal by a gain to obtain a first reference speed for the crane.
Method for operating a variable-speed adjustable pump , in which a delivery mechanism that can be adjusted in a displacement volume per working cycle is driven by means of a variable-speed drive , wherein, within the context of control, at least one variable is controlled to a setpoint (p soll ) by specifying a speed setpoint (n soll ) for a speed of the drive and a setpoint (α soll ) for a characteristic variable determining the displacement volume per working cycle, wherein, in the event of a change in the setpoint (α soll ) for the characteristic variable determining the displacement volume per working cycle, the speed setpoint (n soll ) is adapted by means of feedforward control, depending on a current speed of an adjustment of the delivery mechanism .
A hydraulic system for a vehicle comprising a transmission lube circuit ; a main pump ; a variable displacement charge pump for supplying charge fluid to the main pump , the variable displacement charge pump having a charge pump outlet and a pressure responsive displacement control unit ; a charge fluid line communicating the charge pump outlet with an inlet of the main pump ; a pressure sensing line communicating the charge fluid line with the displacement control unit ; a lube line communicating the charge pump outlet with the transmission lube circuit ; and a fluid restriction in the lube line .
An apparatus, comprising: a fuselage (102; 602; 702; 802) of an aircraft having a first section (300; 604; 704; 804) and a second section (302; 606; 706; 806) to which a tail assembly (122; 610; 710; 810) is to be coupled, the second section (302; 606; 706; 806) aft of the first section (300; 604; 704; 804) and to extend to at least a trailing edge (308; 618; 718; 818) of a horizontal stabilizer (124; 612; 712; 812) of the tail assembly (122; 610; 710; 810), a first width of the first section (300; 604; 704; 804) decreasing from a front to a rear of the first section (300; 604; 704; 804), a second width of the second section (302; 606; 706; 806) being substantially constant from a front to a rear of the second section, characterized in that the second section (302; 606; 706; 806) extends from a leading edge of the horizontal stabilizer (124; 612; 712; 812).
Method for protecting against movement of a motor vehicle on an inclined ramp in a parking space, wherein, sloping away from the motor vehicle , one or more collision objects are moved into a route predefined by the ramp in order to reduce a speed of the motor vehicle still on the ramp in the event of a rolling-away movement of the motor vehicle on the route through collision between one or more collision objects and the motor vehicle , characterized in that a fault message transmitted by the motor vehicle via a communication network is received by a communication interface , wherein the one or more collision objects are moved into the route by a movement apparatus in response to the received fault message.
An externally-driven joint structure (1; 408; 412; 424) comprising: a shaft member that extends in an axial direction; and a plurality of rotatable members that are arranged along the axial direction, and are coupled with each other by the shaft member in an axially rotatable manner, wherein each of the rotatable members includes a pair of face portions that face each other in the axial direction, a side wall portion that is arranged along outer circumferential edges of the pair of face portions , and at least one coupling portion that is arranged at the face portions or the side wall portion and is configured to be coupled with a link member (31; 34; 407; 411; 423) constituting a link of a robot, characterized in that the face portions of the rotatable members are provided with a recess portion with a shape that allows a bearing in the shape of a ring that receives a force that acts in the axial direction to be accommodated between rotatable members that are adjacent to each other in the axial direction. a shaft member that extends in an axial direction; and a plurality of rotatable members that are arranged along the axial direction, and are coupled with each other by the shaft member in an axially rotatable manner, wherein each of the rotatable members includes a pair of face portions that face each other in the axial direction, a side wall portion that is arranged along outer circumferential edges of the pair of face portions , and at least one coupling portion that is arranged at the face portions or the side wall portion and is configured to be coupled with a link member (31; 34; 407; 411; 423) constituting a link of a robot, characterized in that the face portions of the rotatable members are provided with a recess portion with a shape that allows a bearing in the shape of a ring that receives a force that acts in the axial direction to be accommodated between rotatable members that are adjacent to each other in the axial direction. a pair of face portions that face each other in the axial direction, a side wall portion that is arranged along outer circumferential edges of the pair of face portions , and at least one coupling portion that is arranged at the face portions or the side wall portion and is configured to be coupled with a link member (31; 34; 407; 411; 423) constituting a link of a robot, characterized in that the face portions of the rotatable members are provided with a recess portion with a shape that allows a bearing in the shape of a ring that receives a force that acts in the axial direction to be accommodated between rotatable members that are adjacent to each other in the axial direction.
A compound of the following general formula (I) : in the form of one of the enantiomers thereof or a mixture of the enantiomers thereof such as a racemic mixture, or a pharmaceutically acceptable salt and/or solvate thereof, wherein: - represents a single bond, - n represents an integer between 1 and 10, - R 1 represents CO 2 R 10 or CONH 2 , - R 2 represents OH, or - R 1 and R 2 together form, with the carbon atoms which bear them, an optionally substituted heterocycle, preferentially selected from optionally substituted pyrimidine, pyrazole, pyrazolone, oxazoline, isoxazoline, oxazalanone, oxazalanethione, morpholinone and oxazepane rings, the optionally substituted heterocycle not being: carbon 1 designating the carbon atom bearing the group R 1 and carbon 2 designating the carbon atom bearing the group R 2 , - R 3 represents NR 26 R 27 , - R 4 represents H, - R 10 and R 26 to R 27 represent, independently of each other, H or a (C 1 -C 6 ) alkyl, aryl, aryl-(C 1 -C 6 )alkyl or (C 1 -C 6 )alkyl-aryl group, said group being optionally substituted by one or more groups selected from (C 1 -C 6 ) alkyl, OR 35 and NR 36 R 37 , or - R 26 and R 27 together form, with the nitrogen atom which bears them, an optionally substituted nitrogen-containing heterocycle, - R 35 to R 37 represent, independently of each other, H or a (C 1 -C 6 ) alkyl, aryl or aryl-(C 1 -C 6 ) alkyl group, - Ra represents a halogen atom as for example Br or Cl, CN or a (C 1 -C 6 )alkoxy group such as methoxy, and - Rb represents H or a (C 1 -C 6 ) alkoxy group such as methoxy, or - Ra and Rb together form an -OCH 2 O- chain. - represents a single bond, - n represents an integer between 1 and 10, - R 1 represents CO 2 R 10 or CONH 2 , - R 2 represents OH, or - R 1 and R 2 together form, with the carbon atoms which bear them, an optionally substituted heterocycle, preferentially selected from optionally substituted pyrimidine, pyrazole, pyrazolone, oxazoline, isoxazoline, oxazalanone, oxazalanethione, morpholinone and oxazepane rings, the optionally substituted heterocycle not being: carbon 1 designating the carbon atom bearing the group R 1 and carbon 2 designating the carbon atom bearing the group R 2 , - R 3 represents NR 26 R 27 , - R 4 represents H, - R 10 and R 26 to R 27 represent, independently of each other, H or a (C 1 -C 6 ) alkyl, aryl, aryl-(C 1 -C 6 )alkyl or (C 1 -C 6 )alkyl-aryl group, said group being optionally substituted by one or more groups selected from (C 1 -C 6 ) alkyl, OR 35 and NR 36 R 37 , or - R 26 and R 27 together form, with the nitrogen atom which bears them, an optionally substituted nitrogen-containing heterocycle, - R 35 to R 37 represent, independently of each other, H or a (C 1 -C 6 ) alkyl, aryl or aryl-(C 1 -C 6 ) alkyl group, - Ra represents a halogen atom as for example Br or Cl, CN or a (C 1 -C 6 )alkoxy group such as methoxy, and - Rb represents H or a (C 1 -C 6 ) alkoxy group such as methoxy, or - Ra and Rb together form an -OCH 2 O- chain.
Process for producing polycrystalline silicon, comprising introducing a reaction gas comprising a silicon-containing component and hydrogen into a reactor comprising a base plate, an upper reactor section secured to the base plate and at least one support body heated by direct passage of current, on which polycrystalline silicon is deposited, such that at least one polycrystalline silicon rod is obtained, characterized in that , after the deposition has ended, a protective shell or protective wall is placed around the reactor during the deinstallation of the at least one polycrystalline silicon rod from the reactors, wherein, after the deposition has ended, connections on the upper reactor section are removed, the protective shell or protective wall is placed laterally around the deposition reactor and the upper reactor section is subsequently removed, in order to deinstall the at least one polycrystalline silicon rod.
Method for authorising the communication of a network node (IoT1 - IoT4, PANEL) of a communication network (IP2), wherein the authorisation for communication of the network node (IoT1 - IoT4, PANEL) only then takes place if the geographic position (POS BIM ) of the network node (IoT1 - IoT4, PANEL) and the position (POS, POS IPS ) of a defined mobile communication terminal (SMART) essentially match, wherein the position (POS BIM ) of the network node (IoT1 - IoT4, PANEL) in a building information model (BIM) is stored on a server (BIM server), wherein the position (POS, POS IPS ) of the mobile communication terminal (SMART) is determined by way of a position determination system (IPS), wherein the position (POS BIM ) of the network node (IoT1 - IoT4, PANEL) stored in the building information model (BIM) is compared with the position (POS, POS IPS ) of the defined mobile communication terminal (SMART) by means of the network node (IoT1 - IoT4, PANEL) or the defined mobile communication terminal (SMART), and on this basis the network node (IoT1 - IoT4, PANEL) is only then authorised to carry out a communication if the defined mobile communication terminal (SMART) is located geographically at a distance of at most 3m from the corresponding network node (IoT1 - IoT4, PANEL).