A system configured for irreversible electroporation ablation energy delivery comprising a pulse waveform generator ; and an ablation device coupled to the pulse waveform generator , the ablation device including at least one electrode (603 - 606, 609 - 612) configured for irreversible electroporation ablation energy delivery to tissue during use, wherein the pulse waveform generator is configured to deliver voltage pulses to the ablation device in the form of a pulsed waveform, wherein: (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay , characterised in that the pulse waveform generator is further configured to deliver each second set of pulses from the plurality of pulses over a heartbeat such that the plurality of second sets of pulses is deliverable over a series of heartbeats. a pulse waveform generator ; and an ablation device coupled to the pulse waveform generator , the ablation device including at least one electrode (603 - 606, 609 - 612) configured for irreversible electroporation ablation energy delivery to tissue during use, wherein the pulse waveform generator is configured to deliver voltage pulses to the ablation device in the form of a pulsed waveform, wherein: (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay , characterised in that the pulse waveform generator is further configured to deliver each second set of pulses from the plurality of pulses over a heartbeat such that the plurality of second sets of pulses is deliverable over a series of heartbeats. (a) a first level of a hierarchy of the pulsed waveform includes a first set of pulses, each pulse having a pulse time duration, a first time delay separating successive pulses; (b) a second level of the hierarchy of the pulsed waveform includes a plurality of first sets of pulses as a second set of pulses, a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and (c) a third level of the hierarchy of the pulsed waveform includes a plurality of second sets of pulses as a third set of pulses, a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second time delay , <EOS>