mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of the formula (I), Wherein R 1 is halogen; R 2 is C 1-6 alkyl, phenyl, phenylC 1-6 alkyl, pyrazolyl, pyridyl or isoquinolyl; wherein phenyl, phenylC 1-6 alkyl, pyrazolyl and pyridyl are unsubstituted or substituted by one or two or three substituents independently selected from halogen, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 1-6 alkoxyphenylC 1-6 alkoxy, carboxyC 3-7 cycloalkoxy, CN and pyrrolidinylcarbonyl; X is a bond, -C(O)-, -C(O)O- or -C(O)-NH-; A is -C(R 3 R 4 )- or -C(O)-; wherein R 3 is H or C 1-6 alkyl; R 4 is H or C 1-6 alkyl; m is 0 or 1; or a pharmaceutically acceptable salt thereof. R 1 is halogen; R 2 is C 1-6 alkyl, phenyl, phenylC 1-6 alkyl, pyrazolyl, pyridyl or isoquinolyl; wherein phenyl, phenylC 1-6 alkyl, pyrazolyl and pyridyl are unsubstituted or substituted by one or two or three substituents independently selected from halogen, C 1-6 alkyl, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkyl, C 1-6 alkoxyC 1-6 alkoxy, C 1-6 alkoxycarbonyl, C 1-6 alkoxyphenylC 1-6 alkoxy, carboxyC 3-7 cycloalkoxy, CN and pyrrolidinylcarbonyl; X is a bond, -C(O)-, -C(O)O- or -C(O)-NH-; A is -C(R 3 R 4 )- or -C(O)-; wherein R 3 is H or C 1-6 alkyl; R 4 is H or C 1-6 alkyl; R 3 is H or C 1-6 alkyl; R 4 is H or C 1-6 alkyl; m is 0 or 1;
Method of diagnosis or assessing the status of a disease or diseases associated with synaptic degeneration, wherein the disease or diseases associated with synaptic degeneration are one or more of Alzheimer's disease, Creutzfeldt-Jakob disease, traumatic brain injury, stroke, and/or glioma, the method comprising determining the concentration of ß-synuclein in a sample of a patient, wherein the sample of the patient is blood, serum, or plasma, and wherein the method is carried out ex vivo.
A method for drilling an element to be drilled by means of a piercing device and a cutting tool comprising listels and cutting edges , said method comprising a step of determining at least one load value representative of the overall drag due to the internal friction of said piercing device and to the friction of said listels in said element to be drilled, said step of determining at least one load value representative of said overall drag comprising the following sub-steps: - stopping the drilling operation in progress; - partially retracting said cutting tool over a predetermined distance, said predetermined distance being chosen so that said cutting edges are no longer in contact with said element to be drilled while the listels are still inside the hole being drilled in the element to be drilled; - driving said cutting tool with predetermined cutting parameters; - measuring at least one load value when driving said cutting tool with said cutting parameters before its cutting edges again come into contact with said element to be drilled, and after stabilisation of said load values, the at least one load value thus measured being said at least one load value representative of said overall drag due to internal friction of said piercing device and to the friction of said listels in said element to be drilled. - stopping the drilling operation in progress; - partially retracting said cutting tool over a predetermined distance, said predetermined distance being chosen so that said cutting edges are no longer in contact with said element to be drilled while the listels are still inside the hole being drilled in the element to be drilled; - driving said cutting tool with predetermined cutting parameters; - measuring at least one load value when driving said cutting tool with said cutting parameters before its cutting edges again come into contact with said element to be drilled, and after stabilisation of said load values, the at least one load value thus measured being said at least one load value representative of said overall drag due to internal friction of said piercing device and to the friction of said listels in said element to be drilled.
A cabled yarn comprising: at least two single plied yarns each comprising meta-aramid fibres, para-aramid fibres, cellulose-based fibres, and wool fibres, twisted around a centrally located yarn comprising an Elastolefin fibre, wherein the cabled yarn comprises by weight around 23% meta-aramid fibres, around 4% para-aramid fibres, around 33% cellulose-based fibres, around 33% wool fibres, and around 7% Elastolefin fibres, and wherein the wool fibres have a thickness of around 15.5μm to around 29.5μm.
A method for emulating network devices with different clocks, the method comprising: in a network equipment test device : generating or obtaining timing information to produce a first clock; obtaining clock modification information; emulating a plurality of different clocks using the timing information and the clock modification information; and emulating at least one network device that transmits test packets to a device under test using the different clocks, wherein emulating at least one network device includes: inserting timestamps generated using a first emulated clock into a first stream of packets; inserting timestamps generated using a second emulated clock into a second stream of packets; and transmitting the first and second streams of packets to a device under test . generating or obtaining timing information to produce a first clock; obtaining clock modification information; emulating a plurality of different clocks using the timing information and the clock modification information; and emulating at least one network device that transmits test packets to a device under test using the different clocks, wherein emulating at least one network device includes: inserting timestamps generated using a first emulated clock into a first stream of packets; inserting timestamps generated using a second emulated clock into a second stream of packets; and transmitting the first and second streams of packets to a device under test . inserting timestamps generated using a first emulated clock into a first stream of packets; inserting timestamps generated using a second emulated clock into a second stream of packets; and transmitting the first and second streams of packets to a device under test .
A method of receiving a tracking reference signal, TRS, which is received by a user equipment, UE, in a wireless communication system supporting an unlicensed band, the method comprising: receiving, from a base station, a first TRS given by a discovery reference signal, DRS, receiving downlink control information, DCI, scheduling a downlink data, receiving a UE-specific DCI indicating that a second TRS is transmitted in a subframe in which the first TRS is not transmitted based on a tracking performance of the UE being not satisfied (S2910), receiving the second TRS based on the UE-specific DCI (S2920) and performing a tracking based on the first TRS and the second TRS wherein the tracking performance is determined to be satisfied based on the number of TRSs received during a specific duration being equal to or more than a prescribed number, and wherein the second TRS is received before a downlink data is received based on the tracking performance being determined not to be satisfied based on the first TRS. receiving, from a base station, a first TRS given by a discovery reference signal, DRS, receiving downlink control information, DCI, scheduling a downlink data, receiving a UE-specific DCI indicating that a second TRS is transmitted in a subframe in which the first TRS is not transmitted based on a tracking performance of the UE being not satisfied (S2910), receiving the second TRS based on the UE-specific DCI (S2920) and performing a tracking based on the first TRS and the second TRS wherein the tracking performance is determined to be satisfied based on the number of TRSs received during a specific duration being equal to or more than a prescribed number, and wherein the second TRS is received before a downlink data is received based on the tracking performance being determined not to be satisfied based on the first TRS.
Mechanical seal arrangement, comprising: - a first mechanical seal with a rotating slide ring and a stationary slide ring , which define a sealing gap in between them, - a first sealing space that is filled with a sealing liquid, - wherein the first mechanical seal seals off the sealing space against a surrounding area , - a first piston arrangement with a piston element and flexible wall areas that define a first piston interior space , - wherein the first piston interior space is in fluid connection with the first sealing space , - wherein a piston outer surface of the piston element is in fluid connection with the surrounding area , and - a first pre-stressing appliance that exerts a first preload force (F1) on the piston element of the first piston arrangement , - a second mechanical seal with a rotating slide ring and a stationary slide ring , which define a sealing gap in between them, - a second sealing space and - a second piston arrangement with a piston element and flexible wall areas , which define a second piston interior space , - wherein the second piston interior space is in fluid connection with the second sealing space and a second pre-stressing appliance exerts a second preload force (F2) on the second piston arrangement , - wherein the second mechanical seal is arranged between the first sealing space and the second sealing space , - wherein the first piston interior space is an annular space and the piston element of the first piston arrangement is an annular piston. - a first mechanical seal with a rotating slide ring and a stationary slide ring , which define a sealing gap in between them, - a first sealing space that is filled with a sealing liquid, - wherein the first mechanical seal seals off the sealing space against a surrounding area , - a first piston arrangement with a piston element and flexible wall areas that define a first piston interior space , - wherein the first piston interior space is in fluid connection with the first sealing space , - wherein a piston outer surface of the piston element is in fluid connection with the surrounding area , and - a first pre-stressing appliance that exerts a first preload force (F1) on the piston element of the first piston arrangement , - a second mechanical seal with a rotating slide ring and a stationary slide ring , which define a sealing gap in between them, - a second sealing space and - a second piston arrangement with a piston element and flexible wall areas , which define a second piston interior space , - wherein the second piston interior space is in fluid connection with the second sealing space and a second pre-stressing appliance exerts a second preload force (F2) on the second piston arrangement , - wherein the second mechanical seal is arranged between the first sealing space and the second sealing space , - wherein the first piston interior space is an annular space and the piston element of the first piston arrangement is an annular piston.
A wireless node comprising: ∘ an RF modem comprising a circuit board sandwiched between layers of conductive material of the RF modem , ∘ an RF switch array connected to the RF modem , the RF switch array comprising a layer of circuit board sandwiched between layers of conductive material of the RF switch array and ∘ a plurality of antennas connected to the circuit board of the RF switch array via waveguides present in the layers of conductive material of the RF switch array , a first subset of the antennas arranged in a first horizontal plane (H1) and a second subset of the antennas arranged below the first horizontal plane (H1) in a second horizontal plane (H2), adjacent antennas in each subset of the antennas being spaced apart from each other and the spacing between two adjacent antennas in a subset of the antennas being filled by an antenna in the other subset of the antennas . ∘ an RF modem comprising a circuit board sandwiched between layers of conductive material of the RF modem , ∘ an RF switch array connected to the RF modem , the RF switch array comprising a layer of circuit board sandwiched between layers of conductive material of the RF switch array and ∘ a plurality of antennas connected to the circuit board of the RF switch array via waveguides present in the layers of conductive material of the RF switch array , a first subset of the antennas arranged in a first horizontal plane (H1) and a second subset of the antennas arranged below the first horizontal plane (H1) in a second horizontal plane (H2), adjacent antennas in each subset of the antennas being spaced apart from each other and the spacing between two adjacent antennas in a subset of the antennas being filled by an antenna in the other subset of the antennas .
A non-transitory storage medium storing instructions readable and executable by an imaging workstation including at least one electronic processor operatively connected with a display device to perform an image reconstruction method , the method comprising: reconstructing imaging data acquired by an image acquisition device using an iterative image reconstruction algorithm with a fixed number of iterations to generate at least one reconstructed image ; delineating one or more contours of the at least one reconstructed image to determine a region of interest (ROI) of the at least one reconstructed image; computing at least one quality metric value of the ROI, the at least one quality metric value including at least a convergence quality metric; wherein computing the convergence quality metric of the ROI includes computing, during said iterative reconstruction, an intensity versus iteration curve to generate a convergence curve for the ROI , and determining a slope of the convergence curve to determine a convergence value for the ROI ; and displaying , on the display device , the at least one quality metric value including the generated convergence curve, and the at least one reconstructed image showing the ROI. reconstructing imaging data acquired by an image acquisition device using an iterative image reconstruction algorithm with a fixed number of iterations to generate at least one reconstructed image ; delineating one or more contours of the at least one reconstructed image to determine a region of interest (ROI) of the at least one reconstructed image; computing at least one quality metric value of the ROI, the at least one quality metric value including at least a convergence quality metric; wherein computing the convergence quality metric of the ROI includes computing, during said iterative reconstruction, an intensity versus iteration curve to generate a convergence curve for the ROI , and determining a slope of the convergence curve to determine a convergence value for the ROI ; and displaying , on the display device , the at least one quality metric value including the generated convergence curve, and the at least one reconstructed image showing the ROI.
A blade or a vane of a gas turbine, comprising: a first sidewall constituting a pressure side of an airfoil; a second sidewall constituting a suction side of the airfoil, and the first sidewall having a smaller length than the second sidewall , and the first sidewall and the second sidewall are separated from each other; a leading edge (F) at which the first and second sidewalls meet each other; a trailing edge (R) formed at the opposite side of the leading edge (F); a pillar-shaped fin extended between an inner surface of the first sidewall and an inner surface of the second sidewall at the trailing edge (R); a plurality of trailing ribs , wherein the plurality of trailing ribs are extended from an end of the first sidewall to the inner surface of the first sidewall and an end of the second sidewall , and the plurality of trailing ribs are separated from each other in a lengthwise direction of the trailing edge (R); and a pair of cut-back blocks extended between two trailing ribs along the inner surface of the second sidewall , wherein the two cut-back blocks of the pair are positioned subsequently in a flow direction of the cooling fluid characterized in that a front surface of each cut-back block has a gentler slope than a rear surface of the cut-back block , wherein the flow direction of a cooling fluid is from the front surface to the rear surface . a first sidewall constituting a pressure side of an airfoil; a second sidewall constituting a suction side of the airfoil, and the first sidewall having a smaller length than the second sidewall , and the first sidewall and the second sidewall are separated from each other; a leading edge (F) at which the first and second sidewalls meet each other; a trailing edge (R) formed at the opposite side of the leading edge (F); a pillar-shaped fin extended between an inner surface of the first sidewall and an inner surface of the second sidewall at the trailing edge (R); a plurality of trailing ribs , wherein the plurality of trailing ribs are extended from an end of the first sidewall to the inner surface of the first sidewall and an end of the second sidewall , and the plurality of trailing ribs are separated from each other in a lengthwise direction of the trailing edge (R); and a pair of cut-back blocks extended between two trailing ribs along the inner surface of the second sidewall , wherein the two cut-back blocks of the pair are positioned subsequently in a flow direction of the cooling fluid characterized in that a front surface of each cut-back block has a gentler slope than a rear surface of the cut-back block , wherein the flow direction of a cooling fluid is from the front surface to the rear surface .
A method of processing a pixel in a picture, said pixel being defined by original color components in a first color space, the method comprising: checking (S1) whether a color component of said pixel in a second color space resulting in a smallest error between i) a color component in a third color space determined based on said color component in said second color space and a corresponding original color component of said pixel in said third color space determined based upon said original color components in said first color space or between ii) a color component in said first color space determined based on said color component in said second color space and a corresponding one of said original color components in said first color space, causes any color channel of said pixel to fall outside of an allowed range; obtaining (S2) a value of said color component in said second color space using a first function or a first look-up table if said color component in said second color space resulting in said smallest error does not cause any color channel of said pixel to fall outside of said allowed range; and obtaining (S3) a value of said color component in said second color space using a second, different function or a second, different look-up table if said color component in said second color space resulting in said smallest error causes any color channel of said pixel to fall outside of said allowed range. checking (S1) whether a color component of said pixel in a second color space resulting in a smallest error between i) a color component in a third color space determined based on said color component in said second color space and a corresponding original color component of said pixel in said third color space determined based upon said original color components in said first color space or between ii) a color component in said first color space determined based on said color component in said second color space and a corresponding one of said original color components in said first color space, causes any color channel of said pixel to fall outside of an allowed range; obtaining (S2) a value of said color component in said second color space using a first function or a first look-up table if said color component in said second color space resulting in said smallest error does not cause any color channel of said pixel to fall outside of said allowed range; and obtaining (S3) a value of said color component in said second color space using a second, different function or a second, different look-up table if said color component in said second color space resulting in said smallest error causes any color channel of said pixel to fall outside of said allowed range.
A method for detecting target molecules in a sample comprising: (a) obtaining: (i) a plurality of target specific unique binding agent (UBA) mixtures, wherein at least one UBA mixture comprises labeled and unlabeled UBAs at a predetermined ratio, (ii) a plurality of epitope specific barcodes (ESBs) capable of associating with the UBAs, and (iii) a plurality of round-specific assayable polymer subunit (APS) sets, each set comprising a plurality of APSs that are detectably distinct from each other; (b) contacting the mixtures of UBAs with a population of cells comprising the target molecules, wherein the labeled UBAs and the unlabeled UBAs bind to the target molecules; (c) contacting the plurality of ESBs with said population of cells; (d) conducting split pool synthesis using the plurality of round-specific APSs; and (e) obtaining at least one target specific signal by detecting at least part of the UBA-ESB-APS complex. (a) obtaining: (i) a plurality of target specific unique binding agent (UBA) mixtures, wherein at least one UBA mixture comprises labeled and unlabeled UBAs at a predetermined ratio, (ii) a plurality of epitope specific barcodes (ESBs) capable of associating with the UBAs, and (iii) a plurality of round-specific assayable polymer subunit (APS) sets, each set comprising a plurality of APSs that are detectably distinct from each other; (i) a plurality of target specific unique binding agent (UBA) mixtures, wherein at least one UBA mixture comprises labeled and unlabeled UBAs at a predetermined ratio, (ii) a plurality of epitope specific barcodes (ESBs) capable of associating with the UBAs, and (iii) a plurality of round-specific assayable polymer subunit (APS) sets, each set comprising a plurality of APSs that are detectably distinct from each other; (b) contacting the mixtures of UBAs with a population of cells comprising the target molecules, wherein the labeled UBAs and the unlabeled UBAs bind to the target molecules; (c) contacting the plurality of ESBs with said population of cells; (d) conducting split pool synthesis using the plurality of round-specific APSs; and (e) obtaining at least one target specific signal by detecting at least part of the UBA-ESB-APS complex.
A zoom spotlight with variable beam angle, comprising at least one light source , a focussing optical system for emitting a zoom beam , and a zoom element for adjusting the beam angle of the zoom beam emitted by the focussing optical system , wherein the zoom element is a thin-walled scattering and/or expanding element , which is provided with a light-scattering and/or expanding scattering and/or expanding structure and is provided between the focussing optical system and the light source , wherein said scattering and/or expanding element and/or the focussing optical system is/are mounted so as to be movable to and fro for adjusting the beam angle of the emitted zoom beam , characterised in that a swap-out holder for exchanging the scattering and/or expanding element and inserting differently configured scattering and/or expanding elements for producing differently contoured and/or differently coloured beams has an annular film holder for holding the thin-walled scattering and/or expanding element in a form-fitting and/or frictionally engaged manner, which film holder is fastened releasably to an adjustably mounted holder sleeve , wherein the swap-out holder is mounted so as to be movable longitudinally displaceably substantially parallel to the main beam direction along the entire path from the light source to the focussing optical system , so that the scattering and/or expanding element in one end position is positioned directly at the light exit surface of the light source and in another end position is positioned directly at the focussing optical system .