mhurhangee/patent-ind-claim-en huggingface dataset:
A method for determining whether a cancer patient has positively responded to a therapy regimen, the method comprising the steps of: (a) providing a blood plasma sample from the patient collected at a first time point during treatment regimen; (b) providing a blood plasma sample from the patient collected at a second time point during treatment regimen; (c) determining in the samples the sequence of ctDNA of at least a portion known to undergo mutagenesis in cancer of each of the biomarkers listed in Table 1 or Table 2; (d) determining in the samples the ratio of the number of mutations detected in the biomarkers to the volume of the samples, said ratio defined as MMPM or mutant molecules per milliliter-of-plasma, wherein mutations include single-nucleotide variations (SNVs), deletions and insertions (in-dels), and wherein mutations are determined by comparing the sequence data to a reference genome sequence, wherein the reference genome sequence is the canonical human genome assembly; (e) determining that the patient has responded to the therapy regimen if the ratio determined in step (d) in the second sample is lower than in the first sample; or (f) determining that the patient has not responded to the therapy regimen if the ratio determined in step (d) in the second sample is not lower than in the first sample, and altering the therapy regimen, wherein the cancer is selected from among non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and colorectal cancer (CRC), wherein the patient's response to therapy is selected from increased progression free survival (PFS) and increased overall survival (OS), and wherein the therapy regimen is selected from treatment with FOLFOXIRI-bevacizumab, treatment with FOLFOX-bevacizumab, capercitabine-bevacizumab and chemoradiation therapy. (a) providing a blood plasma sample from the patient collected at a first time point during treatment regimen; (b) providing a blood plasma sample from the patient collected at a second time point during treatment regimen; (c) determining in the samples the sequence of ctDNA of at least a portion known to undergo mutagenesis in cancer of each of the biomarkers listed in Table 1 or Table 2; (d) determining in the samples the ratio of the number of mutations detected in the biomarkers to the volume of the samples, said ratio defined as MMPM or mutant molecules per milliliter-of-plasma, wherein mutations include single-nucleotide variations (SNVs), deletions and insertions (in-dels), and wherein mutations are determined by comparing the sequence data to a reference genome sequence, wherein the reference genome sequence is the canonical human genome assembly; (e) determining that the patient has responded to the therapy regimen if the ratio determined in step (d) in the second sample is lower than in the first sample; or (f) determining that the patient has not responded to the therapy regimen if the ratio determined in step (d) in the second sample is not lower than in the first sample, and altering the therapy regimen,
A packet processing method, comprising: receiving , by a forwarding element, a packet through an inbound port; searching , by the forwarding element, a port table according to the inbound port to determine a first offset, a first length, and an identifier of a first table, wherein the first offset, the first length, and the identifier of the first table correspond to the inbound port; determining , by the forwarding element, a first key according to the first offset and the first length, searching the first table according to the first key to determine a first instruction; and processing , by the forwarding element, the packet according to the first instruction. receiving , by a forwarding element, a packet through an inbound port; searching , by the forwarding element, a port table according to the inbound port to determine a first offset, a first length, and an identifier of a first table, wherein the first offset, the first length, and the identifier of the first table correspond to the inbound port; determining , by the forwarding element, a first key according to the first offset and the first length, searching the first table according to the first key to determine a first instruction; and processing , by the forwarding element, the packet according to the first instruction.
An inkjet apparatus comprising: an inkjet assembly having inkjet nozzles through each of which ink flows at a nominal flow rate as it is ejected from the nozzle onto a substrate, and in which ink is held under a nominal negative pressure associated with a characteristic of a meniscus of the ink in the nozzle when ejection of ink from the nozzle is not occurring; recirculation flow paths, each flow path having a nozzle end at which it opens into one of the nozzles and another location spaced from the nozzle end that is to be subjected to a recirculation pressure lower than the nominal negative pressure so that ink is recirculated from the nozzle through the flow path at a recirculation flow rate, each recirculation flow path having a fluidic resistance between the nozzle end and the other location such that a recirculation pressure at the nozzle end of the flow path that results from the recirculation pressure applied at the other location of the flow path is small enough so that any reduction in flow rate below the nominal flow rate when ink is being ejected is less than a threshold, or a change in the nominal negative pressure when ink is not being ejected is less than a threshold, or both; a refill chamber ; and a second recirculation flow path that extends from the refill chamber , the second recirculation flow path from the refill chamber having a second fluidic resistance; wherein the fluidic resistance between the nozzle end and the other location is within ± 50% of the second fluidic resistance. an inkjet assembly having inkjet nozzles through each of which ink flows at a nominal flow rate as it is ejected from the nozzle onto a substrate, and in which ink is held under a nominal negative pressure associated with a characteristic of a meniscus of the ink in the nozzle when ejection of ink from the nozzle is not occurring; recirculation flow paths, each flow path having a nozzle end at which it opens into one of the nozzles and another location spaced from the nozzle end that is to be subjected to a recirculation pressure lower than the nominal negative pressure so that ink is recirculated from the nozzle through the flow path at a recirculation flow rate, each recirculation flow path having a fluidic resistance between the nozzle end and the other location such that a recirculation pressure at the nozzle end of the flow path that results from the recirculation pressure applied at the other location of the flow path is small enough so that any reduction in flow rate below the nominal flow rate when ink is being ejected is less than a threshold, or a change in the nominal negative pressure when ink is not being ejected is less than a threshold, or both; a refill chamber ; and a second recirculation flow path that extends from the refill chamber , the second recirculation flow path from the refill chamber having a second fluidic resistance; wherein the fluidic resistance between the nozzle end and the other location is within ± 50% of the second fluidic resistance.
Method for configuring a planar drive system , wherein the planar drive system comprises a plurality of stator modules adjacent to one another for driving at least one rotor , wherein in each case at least two stator modules comprise outer edges facing one another and as a result there is a spatial neighbourhood relationship between the at least two stator modules , wherein the stator modules each comprise conductor strips for generating a magnetic field and each comprise magnetic field sensors for detecting a magnetic field, characterized by the following steps: - outputting a first control signal in a first output step to at least one transmission stator module of the stator modules , wherein the first control signal comprises the fact that in the transmission stator module at least one conductor strip is intended to be energized; - receiving a positive first detection signal by a reception stator module of the stator modules , wherein the positive first detection signal comprises the fact that at least one magnetic field sensor of the reception stator module has determined a magnetic field; - determining a neighbourhood relationship between the transmission stator module and the reception stator module in a first determining step , wherein the first control signal and the positive first detection signal are taken into account when determining the neighbourhood relationship . - outputting a first control signal in a first output step to at least one transmission stator module of the stator modules , wherein the first control signal comprises the fact that in the transmission stator module at least one conductor strip is intended to be energized; - receiving a positive first detection signal by a reception stator module of the stator modules , wherein the positive first detection signal comprises the fact that at least one magnetic field sensor of the reception stator module has determined a magnetic field; - determining a neighbourhood relationship between the transmission stator module and the reception stator module in a first determining step , wherein the first control signal and the positive first detection signal are taken into account when determining the neighbourhood relationship .
Method for determining the density of fluids from the period duration of a resonant oscillation mode of a flexural resonator with U-shaped oscillating tube, wherein the resonator is set into resonant undamped oscillation with an excitation amplified circuit, - wherein the resonator during a time interval Δt 1 is set by means of an excitation amplifier into forced undamped oscillation, - wherein the excitation of the forced oscillation is periodically interrupted for a time interval Δt 2 , - wherein the resonator during the time interval Δt 2 of the interruption is allowed to oscillate in a damped manner freely and in accordance with its quality, - wherein in this time interval Δt 2 the period of this free, damped oscillation is used for determining the density, and - wherein after the measurement of the periods of the free, damped oscillation the resonator is again excited to resonant, undamped oscillation, wherein at least two resonant oscillation modes of the resonator are evaluated by means of superimposing, simultaneously excited by the excitation amplifier and oscillating freely. - wherein the resonator during a time interval Δt 1 is set by means of an excitation amplifier into forced undamped oscillation, - wherein the excitation of the forced oscillation is periodically interrupted for a time interval Δt 2 , - wherein the resonator during the time interval Δt 2 of the interruption is allowed to oscillate in a damped manner freely and in accordance with its quality, - wherein in this time interval Δt 2 the period of this free, damped oscillation is used for determining the density, and - wherein after the measurement of the periods of the free, damped oscillation the resonator is again excited to resonant, undamped oscillation,
A composition comprising parietal polysaccharides from at least one Candida species and parietal polysaccharides from at least one Saccharomyces species, wherein said parietal polysaccharides from at least one Candida species and parietal polysaccharides from at least one Saccharomyces species are chitin, mannan-oligosaccharides, Beta-1,3 glucans and Beta-1,6 glucans, in an amount ranging from 20 to 80 weight percent based on the total weight of said composition.
A method of performing a speech-to-text, STT, processing in a digital device, comprising: activating a text input field ; checking an attribute of the text input field; receiving a request for the STT processing for data to be inputted to the text input field; determining whether an attribute type of the text input field is a security attribute such as a sensitive attribute; if the attribute type of the text input field is the security attribute as a result of the determination, blocking the STT processing, and displaying a virtual keyboard , and if the attribute type of the text input field is not the security attribute as a result of the determination, displaying an STT plug-in , wherein the blocking the STT processing comprises: displaying a block message related to the STT processing and a query message related to a presence or non-presence of a release of the security attribute type of the text input field after blocking the STT processing; and if the security attribute type is not released based on the query message, continuing the blocking of the STT processing. activating a text input field ; checking an attribute of the text input field; receiving a request for the STT processing for data to be inputted to the text input field; determining whether an attribute type of the text input field is a security attribute such as a sensitive attribute; if the attribute type of the text input field is the security attribute as a result of the determination, blocking the STT processing, and displaying a virtual keyboard , and if the attribute type of the text input field is not the security attribute as a result of the determination, displaying an STT plug-in , wherein the blocking the STT processing comprises: displaying a block message related to the STT processing and a query message related to a presence or non-presence of a release of the security attribute type of the text input field after blocking the STT processing; and if the security attribute type is not released based on the query message, continuing the blocking of the STT processing. displaying a block message related to the STT processing and a query message related to a presence or non-presence of a release of the security attribute type of the text input field after blocking the STT processing; and if the security attribute type is not released based on the query message, continuing the blocking of the STT processing.
A pressure safety device for use with a bag valve mask, BVM, including a bag assembly having a bag connector for detachably mating to a mask connector on a patient mask, said pressure safety device comprising: a housing having a bag port , a mask fitting , and a flow path from the bag port to the mask fitting , wherein the bag port is configured to detachably connect to the bag connector on the BVM and the mask fitting is configured to detachably connect to the mask connector on the BVM ; and an automatic flow reduction valve located on the flow path in the housing and configured to impede flow when a pressure or flow rate on a bag connector side of the automatic flow reduction valve exceeds a maximum threshold value; wherein the automatic flow reduction valve comprises a deformable seal having an open position and a closed position; wherein the deformable seal is configured to deform to fully block the flow path in response to the pressure or flow rate exceeding the maximum threshold value; and characterized in that the deformable seal comprises a conical periphery configured to evert from an open, unstressed configuration to a closed, stressed configuration in response to the pressure or flow rate exceeding the maximum threshold value. a housing having a bag port , a mask fitting , and a flow path from the bag port to the mask fitting , wherein the bag port is configured to detachably connect to the bag connector on the BVM and the mask fitting is configured to detachably connect to the mask connector on the BVM ; and an automatic flow reduction valve located on the flow path in the housing and configured to impede flow when a pressure or flow rate on a bag connector side of the automatic flow reduction valve exceeds a maximum threshold value; wherein the automatic flow reduction valve comprises a deformable seal having an open position and a closed position; wherein the deformable seal is configured to deform to fully block the flow path in response to the pressure or flow rate exceeding the maximum threshold value; and characterized in that the deformable seal comprises a conical periphery configured to evert from an open, unstressed configuration to a closed, stressed configuration in response to the pressure or flow rate exceeding the maximum threshold value.
A bone plate comprising: a main bone plate body having two opposing curved sections adapted for a clavicle; a bendable waist portion narrower than the main body of the bone plate; and a node at each end of the main body; wherein the main body includes: a bone-facing bottom surface and an opposite upper surface; one or more slots extending from the bone-facing bottom surface to the opposite upper surface, characterised in that one or more of the slots have a cut-out region on a bottom surface of the bone plate configured to receive a bending iron, and wherein the cut-out region does not extend to the upper surface of the bone plate. a main bone plate body having two opposing curved sections adapted for a clavicle; a bendable waist portion narrower than the main body of the bone plate; and a node at each end of the main body; wherein the main body includes: a bone-facing bottom surface and an opposite upper surface; one or more slots extending from the bone-facing bottom surface to the opposite upper surface, characterised in that one or more of the slots have a cut-out region on a bottom surface of the bone plate configured to receive a bending iron, and a bone-facing bottom surface and an opposite upper surface; one or more slots extending from the bone-facing bottom surface to the opposite upper surface, characterised in that one or more of the slots have a cut-out region on a bottom surface of the bone plate configured to receive a bending iron, and wherein the cut-out region does not extend to the upper surface of the bone plate.
A wad for a shotgun cartridge , the wad comprising a cup-shaped member having an open end and closed end , and wherein the cup-shaped member comprises a biodegradable fibrous material; wherein the cup-shaped member comprises a fabric material ; wherein the cup-shaped member is formed in part from a pulp material ; characterised in that the cup-shaped member comprises at least one of: (i) the fabric material laminated onto the pulp material ; and (ii) the fabric material embedded into the pulp material .
A method of forming a superconductor device structure , the method comprising: forming a first dielectric layer (16; 56) overlying a substrate (12; 52); forming a base electrode (18; 66) in the first dielectric player, the base electrode having a top surface aligned with the top surface of the first dielectric layer; forming a junction material stack over the base electrode; forming a hardmask (34; 76) over the junction material stack; etching away a portion of the junction material stack to form a Josephson junction, JJ (24; 78) over the base electrode; depositing a second dielectric layer (22; 79) over the hardmask, the JJ, the base electrode and the first dielectric layer; and forming a first contact (26; 94) through the second dielectric layer to the base electrode to electrically couple the first contact to a first end of the JJ; and forming a second contact (28; 94) through the second dielectric layer and the hardmask to electrically couple the second contact to a second end of the JJ. forming a first dielectric layer (16; 56) overlying a substrate (12; 52); forming a base electrode (18; 66) in the first dielectric player, the base electrode having a top surface aligned with the top surface of the first dielectric layer; forming a junction material stack over the base electrode; forming a hardmask (34; 76) over the junction material stack; etching away a portion of the junction material stack to form a Josephson junction, JJ (24; 78) over the base electrode; depositing a second dielectric layer (22; 79) over the hardmask, the JJ, the base electrode and the first dielectric layer; and forming a first contact (26; 94) through the second dielectric layer to the base electrode to electrically couple the first contact to a first end of the JJ; and forming a second contact (28; 94) through the second dielectric layer and the hardmask to electrically couple the second contact to a second end of the JJ.
An ink delivery system , comprising: at least one ink cartridge dispenser including an ink cartridge holder for holding an ink cartridge storing printing ink, in particular the at least one ink cartridge dispenser including from two to six ink cartridges; at least one ink level sensor ; an ink fountain roller and an ink fountain blade , forming a dispensed ink area receiving printing ink from the ink cartridge, the ink fountain roller being rotatable; and a support supporting the at least one ink cartridge dispenser movably parallel to a longitudinal axis of the ink fountain roller, the ink cartridge dispenser movable along the support and fixable to the support manually; characterized in that the ink delivery system comprises: a manual clamp , the manual clamp when released permitting manual movement of the ink cartridge dispenser and when closed fixing the ink cartridge dispenser to the support. at least one ink cartridge dispenser including an ink cartridge holder for holding an ink cartridge storing printing ink, in particular the at least one ink cartridge dispenser including from two to six ink cartridges; at least one ink level sensor ; an ink fountain roller and an ink fountain blade , forming a dispensed ink area receiving printing ink from the ink cartridge, the ink fountain roller being rotatable; and a support supporting the at least one ink cartridge dispenser movably parallel to a longitudinal axis of the ink fountain roller, the ink cartridge dispenser movable along the support and fixable to the support manually; characterized in that the ink delivery system comprises: a manual clamp , the manual clamp when released permitting manual movement of the ink cartridge dispenser and when closed fixing the ink cartridge dispenser to the support.