A microscope, comprising: an illumination assembly operable to illuminate a sample under observation of the microscope; an image capture device operable to capture an initial image set of the illuminated sample; and a processor coupled to the image capture device ; wherein the illumination assembly is configured to illuminate the sample at a plurality of illumination conditions, wherein the initial image set comprises a plurality of images, each of the plurality of images corresponding to a different illumination condition, and wherein the plurality of illumination conditions comprises at least one of an illumination angle, an illumination wavelength, an illumination pattern, illumination intensity, or illumination position; wherein the processor is configured to identify an area of the sample that comprises at least one of artifact or empty space from one or more of the plurality of images; and wherein the processor is configured to generate a computational image from the plurality of images, and wherein generating the computational image comprises: operating the processor in a first mode in response to identifying the area of the sample comprising the at least one of artifact or empty space and in a second mode in response to identifying an area of the sample that does not comprise the at least one of artifact or empty space; and in the first mode and the second mode, operating the processor to output portions of the computational image with a first resolution and second resolution, respectively, the first resolution being less than the second resolution. an illumination assembly operable to illuminate a sample under observation of the microscope; an image capture device operable to capture an initial image set of the illuminated sample; and a processor coupled to the image capture device ; wherein the illumination assembly is configured to illuminate the sample at a plurality of illumination conditions, wherein the initial image set comprises a plurality of images, each of the plurality of images corresponding to a different illumination condition, and wherein the plurality of illumination conditions comprises at least one of an illumination angle, an illumination wavelength, an illumination pattern, illumination intensity, or illumination position; wherein the processor is configured to identify an area of the sample that comprises at least one of artifact or empty space from one or more of the plurality of images; and wherein the processor is configured to generate a computational image from the plurality of images, and wherein generating the computational image comprises: operating the processor in a first mode in response to identifying the area of the sample comprising the at least one of artifact or empty space and in a second mode in response to identifying an area of the sample that does not comprise the at least one of artifact or empty space; and in the first mode and the second mode, operating the processor to output portions of the computational image with a first resolution and second resolution, respectively, the first resolution being less than the second resolution. operating the processor in a first mode in response to identifying the area of the sample comprising the at least one of artifact or empty space and in a second mode in response to identifying an area of the sample that does not comprise the at least one of artifact or empty space; and in the first mode and the second mode, operating the processor to output portions of the computational image with a first resolution and second resolution, respectively, the first resolution being less than the second resolution. <EOS>