A fitting for coupling fluidic paths, comprising: a coupling body having a threaded bore, tapered cavity and narrow bore for receiving a tube assembly, the tapered cavity extending from an end of the threaded bore and the narrow bore extending from an end of the tapered cavity that is opposite to the threaded bore, the narrow bore having a sealing surface at an end opposite the tapered cavity with a channel extending from the sealing surface to pass a fluid; a compression screw having an axial bore, a threaded portion in engagement with the threaded bore of the coupling body and a drive surface; a tube having an endface with a pocket having a depth formed therein, the tube extending through the axial bore of the compression screw ; and a collet secured to an outer surface of the tube and having a first end configured to receive the drive surface of the compression screw and a tapered surface to engage a surface of the tapered cavity; characterized in that the fitting further comprises: a polymer seal having a stem portion, a flange portion and an axial channel to pass a fluid, the stem portion disposed in the pocket and having a length that is greater than the depth of the pocket so that the flange portion is separated from the endface by a gap, wherein a fluidic seal is formed between the tube and the sealing surface of the narrow bore when the endface of the tube is forced against the flange portion of the polymer seal . a coupling body having a threaded bore, tapered cavity and narrow bore for receiving a tube assembly, the tapered cavity extending from an end of the threaded bore and the narrow bore extending from an end of the tapered cavity that is opposite to the threaded bore, the narrow bore having a sealing surface at an end opposite the tapered cavity with a channel extending from the sealing surface to pass a fluid; a compression screw having an axial bore, a threaded portion in engagement with the threaded bore of the coupling body and a drive surface; a tube having an endface with a pocket having a depth formed therein, the tube extending through the axial bore of the compression screw ; and a collet secured to an outer surface of the tube and having a first end configured to receive the drive surface of the compression screw and a tapered surface to engage a surface of the tapered cavity; characterized in that the fitting further comprises: a polymer seal having a stem portion, a flange portion and an axial channel to pass a fluid, the stem portion disposed in the pocket and having a length that is greater than the depth of the pocket so that the flange portion is separated from the endface by a gap, wherein a fluidic seal is formed between the tube and the sealing surface of the narrow bore when the endface of the tube is forced against the flange portion of the polymer seal . a polymer seal having a stem portion, a flange portion and an axial channel to pass a fluid, the stem portion disposed in the pocket and having a length that is greater than the depth of the pocket so that the flange portion is separated from the endface by a gap, wherein a fluidic seal is formed between the tube and the sealing surface of the narrow bore when the endface of the tube is forced against the flange portion of the polymer seal . <EOS>