mhurhangee/patent-ind-claim-en huggingface dataset:
A variant adeno-associated virus (AAV) capsid protein comprising a peptide insertion of from 7 amino acids to 20 amino acids in the GH-loop of the capsid protein relative to a corresponding parental AAV capsid protein that is the same AAV capsid protein of the same wild-type AAV serotype as the variant AAV capsid protein but that does not comprise the peptide insertion of the variant AAV capsid protein, wherein the peptide insertion comprises the amino acid sequence NKIQRTD (SEQ ID NO: 13), wherein the insertion site is located between two adjacent amino acids at a position between amino acids 570 and 611 of VP1 of AAV2 (SEQ ID NO:2), or the corresponding position in the capsid protein of another AAV serotype wherein the insertion site is located within: (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; wherein the variant capsid protein, when present in an AAV virion, confers increased infectivity of a muscle cell compared to the infectivity of a muscle cell by an AAV virion comprising the corresponding parental AAV capsid protein. wherein the peptide insertion comprises the amino acid sequence NKIQRTD (SEQ ID NO: 13), wherein the insertion site is located between two adjacent amino acids at a position between amino acids 570 and 611 of VP1 of AAV2 (SEQ ID NO:2), or the corresponding position in the capsid protein of another AAV serotype wherein the insertion site is located within: (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; (i) amino acids 571-612 of AAV1 VP1, (ii) amino acids 571-612 of AAV3A VP1, (iii) amino acids 571-612 of AAV3B VP1, (iv) amino acids 569-610 of AAV4 VP1, (v) amino acids 560-601 of AAV5 VP1 (vi) amino acids 571-612 of AAV6 VP1, (vii) amino acids 572-613 of AAV7 VP1, (viii) amino acids 573-614 of AAV8 VP1 (ix) amino acids 571-612 of AAV9 VP1, or (x) amino acids 573-614 of AAV10 VP1; wherein the variant capsid protein, when present in an AAV virion, confers increased infectivity of a muscle cell compared to the infectivity of a muscle cell by an AAV virion comprising the corresponding parental AAV capsid protein.
A heterodimeric, conditionally active chimeric antigen receptor (CAR) comprising: a first polypeptide comprising an antigen-binding domain that comprises a single chain antibody variable region that specifically binds to CD19 or an antigen expressed by a B cell, a first member of the dimerization pair, and a first transmembrane domain; and a second polypeptide comprising a second member of a dimerization pair, a second transmembrane domain, and an intracellular signaling domain; wherein a dimerizing agent dimerizes the heterodimeric CAR when the first and second polypeptides are expressed by a cell with the dimerizing agent bound between the dimerization pair members of the first and second polypeptides. a first polypeptide comprising an antigen-binding domain that comprises a single chain antibody variable region that specifically binds to CD19 or an antigen expressed by a B cell, a first member of the dimerization pair, and a first transmembrane domain; and a second polypeptide comprising a second member of a dimerization pair, a second transmembrane domain, and an intracellular signaling domain; wherein a dimerizing agent dimerizes the heterodimeric CAR when the first and second polypeptides are expressed by a cell with the dimerizing agent bound between the dimerization pair members of the first and second polypeptides.
A motor bobbin around which a coil is to be wound, comprising a first and a second motor bobbin; each motor bobbin comprising: an insulating paper; and a pair of molded resin articles , wherein the insulating paper and the molded resin articles are connected and fixed to each other without using an adhesive agent, a surface of the insulating paper in contact with the molded resin articles comprises an aramid paper comprising an aramid fibrid and an aramid short fiber, the insulating paper is obtained by melt-extruding and thermally melt-bonding a resin onto the aramid paper comprising the aramid fibrid and the aramid short fiber and subjecting the surface comprising the aramid paper to a surface treatment, each motor bobbin is obtained by bringing a molten portion of the molded resin articles into contact with the aramid paper, each motor bobbin further comprising a bobbin body at least partially made of the insulating paper, and a pair of the molded resin articles connected to both ends of the bobbin body in longitudinal direction; the first and the second motor bobbin being arranged such that a stator core can be arranged between them when they are connected. an insulating paper; and a pair of molded resin articles , wherein the insulating paper and the molded resin articles are connected and fixed to each other without using an adhesive agent, a surface of the insulating paper in contact with the molded resin articles comprises an aramid paper comprising an aramid fibrid and an aramid short fiber, the insulating paper is obtained by melt-extruding and thermally melt-bonding a resin onto the aramid paper comprising the aramid fibrid and the aramid short fiber and subjecting the surface comprising the aramid paper to a surface treatment, each motor bobbin is obtained by bringing a molten portion of the molded resin articles into contact with the aramid paper, each motor bobbin further comprising a bobbin body at least partially made of the insulating paper, and a pair of the molded resin articles connected to both ends of the bobbin body in longitudinal direction; the first and the second motor bobbin being arranged such that a stator core can be arranged between them when they are connected.
An electric tool, having: a motor , having a stator and a rotor located inside the stator ; a motor housing of a cylindrical shape, accommodating and supporting the motor ; a cooling fan , attached to a rotation shaft of the motor and rotating in synchronization with the motor ; and a power transmission mechanism , transmitting a rotational force of the motor to a tip tool , wherein the motor is cooled by flowing an air generated by the cooling fan from an opening on one side of the motor housing toward an opening on the other side of the motor housing , wherein a fan guide is provided, guiding a cooling air generated by the cooling fan from an intake port to an exhaust port , and the fan guide guides the cooling air to concentrate inside the stator , the electric tool being characterized in that : the stator has a nonmagnetic insulator at an end, and the fan guide guides the cooling air by engaging with the insulator in a concavo-convex manner in an axial direction. a motor , having a stator and a rotor located inside the stator ; a motor housing of a cylindrical shape, accommodating and supporting the motor ; a cooling fan , attached to a rotation shaft of the motor and rotating in synchronization with the motor ; and a power transmission mechanism , transmitting a rotational force of the motor to a tip tool , wherein the motor is cooled by flowing an air generated by the cooling fan from an opening on one side of the motor housing toward an opening on the other side of the motor housing , wherein a fan guide is provided, guiding a cooling air generated by the cooling fan from an intake port to an exhaust port , and the fan guide guides the cooling air to concentrate inside the stator , the electric tool being characterized in that : the stator has a nonmagnetic insulator at an end, and the fan guide guides the cooling air by engaging with the insulator in a concavo-convex manner in an axial direction.
A method for operating a gas turbine system, wherein the gas turbine system comprises a compressor for compression of inlet air, a combustor for combustion of a fuel gas with compressed inlet air to form an exhaust gas, a heat recovery steam generator for collecting at least one portion of the exhaust gas, a scrubber for scrubbing the fuel with a scrubbing fluid before it is fed into the combustor, a direct contact cooler for cooling the at least one portion of the exhaust gas discharged from the heat recovery steam generator with a cooling fluid, comprising: introducing the scrubbing fluid discharged from the scrubber into the direct contact cooler, contacting the scrubbing fluid in the direct contact cooler with the at least one portion of the exhaust gas discharged from the heat recovery steam generator in order to remove a portion of nitrogen oxide therefrom; feeding the exhaust gas discharged from the direct contact cooler into the compressor. introducing the scrubbing fluid discharged from the scrubber into the direct contact cooler, contacting the scrubbing fluid in the direct contact cooler with the at least one portion of the exhaust gas discharged from the heat recovery steam generator in order to remove a portion of nitrogen oxide therefrom; feeding the exhaust gas discharged from the direct contact cooler into the compressor.
A satellite radiowave receiving device , comprising a receiver acquiring and receiving radiowaves from a positioning satellite (S i ) and a processor performing a positioning operation based on the radiowaves received by the receiver to obtain a current position of the satellite radiowave receiving device , the processor causes the receiver to stop an acquiring operation of radiowaves from a new positioning satellite (S i ) under a predetermined condition while radiowaves are being acquired from a required number of positioning satellites (S i ) for the positioning operation, characterized in that : the processor causes the receiver to resume the acquiring operation if a rate of a low-accuracy period in a first reference period is equal to or greater than a predetermined first rate during a stop of the acquiring operation, the low-accuracy period being a period in which an error range of the obtained current position is greater than a reference.
Mesembrenone, or a pharmaceutically acceptable salt thereof, for use as a medicament or dietary supplement for preventing or treating a disease or condition that responds to treatment with a PDE-4 inhibitor, wherein the disease or condition is selected from the group consisting of Alzheimer's disease; disorders of cognition and memory; Parkinsons Disease; asthma; chronic obstructive pulmonary disease (COPD); allergic rhinitis; rheumatoid arthritis; psoriasis; atopic dermatitis; and Crohn's disease.
A filtering injection needle assembly for a syringe , comprising: an injection needle including a needle and a hub for supporting the needle and configured to be couplable to the syringe ; and a cap in the form of a hollow pipe configured to receive the needle and to be hermetically couplable to an outer periphery of the hub and including a filter , wherein the hub is formed with a through-hole for communication between an inside and an outside of the hub , and opening/closing of the through-hole is controlled by a one-way valve means on the hub , and wherein the one-way valve means is configured to be closed when an injection liquid is injected an injection needle including a needle and a hub for supporting the needle and configured to be couplable to the syringe ; and a cap in the form of a hollow pipe configured to receive the needle and to be hermetically couplable to an outer periphery of the hub and including a filter , wherein the hub is formed with a through-hole for communication between an inside and an outside of the hub , and opening/closing of the through-hole is controlled by a one-way valve means on the hub , and wherein the one-way valve means is configured to be closed when an injection liquid is injected
A valve body , comprising a membrane cooperating with a valve seat, the valve body and the membrane being connected to each other in the area of a laser weld in an integral and fluid-tight manner, characterized in - that the membrane and the valve body are configured free of absorption additives, - that the material of the valve body comprises polypropylene and/or polyethylene, and - that the material of the membrane comprises a thermoplastic elastomer. - that the membrane and the valve body are configured free of absorption additives, - that the material of the valve body comprises polypropylene and/or polyethylene, and - that the material of the membrane comprises a thermoplastic elastomer.
Exciter system for inducing vibrations in railway bridges based on harmonic forces which can be transported long distances by railway and is capable of carrying out dynamic testing prior to track installation, by inducing vibrations based on harmonic, impulsive, and transient forces, said system being made up of a vertical hydraulic actuator and a variable-weight reaction mass vertically guided by linear bearings preventing any horizontal movement of said mass with respect to a frame and driven by a piston of the hydraulic actuator , which is integrally assembled on a railway wagon designed for such purpose, which system incorporates a variable-weight ballast for the purpose of applying variable forces of different intensity without losing contact with the rails, wherein a movement of the piston of the actuator is controlled by a computer system programmable for such purpose, allowing the actuator to apply general forces, in particular harmonic, impulsive, and transient forces, on the bridge, such that they do not exceed a maximum acceptable displacement of the piston , wherein forces which the actuator applies on the bridge are aggregately measured via a sensor located between the actuator and the wagon , the wagon comprises hydraulic equipment capable of transmitting excitation directly to the bridge, without going through a rolling system of the wagon, via false wheels , the system further comprises additional force and vibration sensors arranged at each of the false wheels .
Harvesting machine , in particular a forage wagon or baler, comprising a pick-up unit , preferably a pick-up roller, comprising a conveying channel downstream of the pick-up unit in the conveying direction of the harvested crop and comprising a conveying rotor which has a large number of conveying elements , for example conveying tines, which project into the conveying channel and have a conveying tip at their outer end, and comprising a plurality of cutting blades which optionally project into the conveying channel and interact with the conveying elements of the conveying rotor in order to comminute the harvested crop, the conveying tip of the conveying element being provided so as to be asymmetrical in relation to a central longitudinal plane of the conveying element , characterised in that the conveying tip of the conveying element has a smaller lateral positional distance from a cutting blade associated with the conveying element than the central longitudinal plane of the conveying element .
A nickel-base superalloy consisting of, by weight: 14.75 to 26.5 percent cobalt; 4.1 to 4.65 percent aluminium; 1.1 to 1.9 percent titanium; 3.85 to 6.3 percent tantalum; 1.2 to 2.55 percent niobium; up to 0.07 percent boron; up to 0.06 percent carbon; up to 14.0 percent chromium; up to 1.0 percent iron; up to 1.0 percent manganese; up to 4.2 percent molybdenum; up to 0.5 percent silicon; up to 4.9 percent tungsten; up to 0.1 percent zirconium; the balance being nickel and incidental impurities; wherein the overall concentration in the alloy of aluminium, titanium, tantalum, and niobium is from 13 to 14 atomic percent and the atomic ratio of aluminium to titanium is from 4.625:1 to 6.333:1. 14.75 to 26.5 percent cobalt; 4.1 to 4.65 percent aluminium; 1.1 to 1.9 percent titanium; 3.85 to 6.3 percent tantalum; 1.2 to 2.55 percent niobium; up to 0.07 percent boron; up to 0.06 percent carbon; up to 14.0 percent chromium; up to 1.0 percent iron; up to 1.0 percent manganese; up to 4.2 percent molybdenum; up to 0.5 percent silicon; up to 4.9 percent tungsten; up to 0.1 percent zirconium; the balance being nickel and incidental impurities; wherein the overall concentration in the alloy of aluminium, titanium, tantalum, and niobium is from 13 to 14 atomic percent and the atomic ratio of aluminium to titanium is from 4.625:1 to 6.333:1.
A camera device , comprising: an image pickup element ; a substrate mounted with the image pickup element thereon; and a housing accommodating the image pickup element therein, wherein the housing comprises an upper half and a lower half ; wherein the upper half of the housing is formed with an aperture into which a lens is disposed and includes a plurality of support members, wherein an external edge portion of the substrate is stuck with an adhesive , and wherein the substrate includes application areas to which the adhesive is applied, at the external edge portion stuck with the upper half of the housing , wherein the adhesive is an ultraviolet curable adhesive; and characterized in that along at least two of lateral walls of the upper half of the housing the plurality of support members are pillars juxtaposed to each other along each of the lateral walls and integrally provided on an internal surface of the lateral walls of the upper half , and the application areas of the substrate are stuck to the upper half having the plurality of pillars of the at least two lateral walls such that the image pickup element faces an inside of the upper half so as to be opposed to the image pickup lens fitted to the upper surface . an image pickup element ; a substrate mounted with the image pickup element thereon; and a housing accommodating the image pickup element therein, wherein the housing comprises an upper half and a lower half ; wherein the upper half of the housing is formed with an aperture into which a lens is disposed and includes a plurality of support members, wherein an external edge portion of the substrate is stuck with an adhesive , and wherein the substrate includes application areas to which the adhesive is applied, at the external edge portion stuck with the upper half of the housing , wherein the adhesive is an ultraviolet curable adhesive; and characterized in that along at least two of lateral walls of the upper half of the housing the plurality of support members are pillars juxtaposed to each other along each of the lateral walls and integrally provided on an internal surface of the lateral walls of the upper half , and the application areas of the substrate are stuck to the upper half having the plurality of pillars of the at least two lateral walls such that the image pickup element faces an inside of the upper half so as to be opposed to the image pickup lens fitted to the upper surface .
A device for laying floor and wall covering for outside corners, being in the form of a single piece ready to be used directly, regardless of its size and without requiring a jig or specific fitting tools, and without using tools necessary for transforming the device from one state to another, the single piece consisting of a rigid central first portion , and a flexible peripheral second portion overmolded on the central first portion , the central first portion is substantially in the shape of a quarter of a truncated cone, and the flexible peripheral second portion is substantially triangular in shape and extends from the whole periphery of the central portion , said peripheral portion is intended to bear against a floor portion and against wall portions that are disposed facing said device.
A cleaner attachment device, comprising an elongate body with a plurality of apertures arranged helically along the body, and a plurality resiliently deformable portions arranged along the body and extending from the body.
A method for wireless communication at a user equipment, UE , comprising: receiving two or more downlink control information messages that each schedule respective downlink transmissions, wherein at least one downlink control information message of the two or more downlink control information messages is multiplexed with a downlink transmission and schedules an additional downlink transmission that is after the downlink transmission, and wherein a feedback message for the respective downlink transmissions is to be transmitted during a same transmission occasion; identifying , for each downlink transmission that is multiplexed with a downlink control information message, a time period comprising a beginning of the downlink transmission; determining an order of the two or more downlink control information messages based at least in part on the time period comprising the beginning of the downlink transmission; and transmitting , during the same transmission occasion, the feedback message for the respective downlink transmissions scheduled by the two or more downlink control information messages, wherein the feedback message is based at least in part on the order of the two or more downlink control information messages. receiving two or more downlink control information messages that each schedule respective downlink transmissions, wherein at least one downlink control information message of the two or more downlink control information messages is multiplexed with a downlink transmission and schedules an additional downlink transmission that is after the downlink transmission, and wherein a feedback message for the respective downlink transmissions is to be transmitted during a same transmission occasion; identifying , for each downlink transmission that is multiplexed with a downlink control information message, a time period comprising a beginning of the downlink transmission; determining an order of the two or more downlink control information messages based at least in part on the time period comprising the beginning of the downlink transmission; and transmitting , during the same transmission occasion, the feedback message for the respective downlink transmissions scheduled by the two or more downlink control information messages, wherein the feedback message is based at least in part on the order of the two or more downlink control information messages.