A compound of Formula A or an isotopically-labeled compound or a pharmaceutically acceptable salt thereof: wherein: R 1 is -CN; -Cl, -Br, or -F; Q is: (i) -(CH=CR 2 )-, where R 2 is H, or -F; or (ii) -(C=N)- K is independently for each occurrance -H or a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; and J is: (a) linear, or branched alkyl of up to 6 carbon atoms which is optionally substituted with: (i) a cycloalkyl of up to 6 carbon atoms; or (ii) aryl which is optionally substituted with one or more halogen or a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; (b) trimethylsilyl; (c) cycloalkyl of up to 6 carbon atoms which is optionally substituted on one or more carbon atoms thereof with, independently for each occurrence: (i) a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms which is optionally substituted with a halogen; or (ii) halogen; (d) a bridged bicyclo alkyl of the formula: where n, m and p are independently 1 to 3 and the sum of n+m+p is 6 or less, and wherein any of the ring carbon atoms may optionally be substituted with a a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; or (e) aryl of the formula: wherein, independently: A 2 is -H, -Br, or -F; A 3 is -H, -Cl, -Br, or -F; A 4 is -H, -Cl, -CH 3 , -Br, or -F. R 1 is -CN; -Cl, -Br, or -F; Q is: (i) -(CH=CR 2 )-, where R 2 is H, or -F; or (ii) -(C=N)- K is independently for each occurrance -H or a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; and J is: (a) linear, or branched alkyl of up to 6 carbon atoms which is optionally substituted with: (i) a cycloalkyl of up to 6 carbon atoms; or (ii) aryl which is optionally substituted with one or more halogen or a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; (b) trimethylsilyl; (c) cycloalkyl of up to 6 carbon atoms which is optionally substituted on one or more carbon atoms thereof with, independently for each occurrence: (i) a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms which is optionally substituted with a halogen; or (ii) halogen; (d) a bridged bicyclo alkyl of the formula: where n, m and p are independently 1 to 3 and the sum of n+m+p is 6 or less, and wherein any of the ring carbon atoms may optionally be substituted with a a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; or (e) aryl of the formula: wherein, independently: A 2 is -H, -Br, or -F; A 3 is -H, -Cl, -Br, or -F; A 4 is -H, -Cl, -CH 3 , -Br, or -F. (a) linear, or branched alkyl of up to 6 carbon atoms which is optionally substituted with: (i) a cycloalkyl of up to 6 carbon atoms; or (ii) aryl which is optionally substituted with one or more halogen or a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; (b) trimethylsilyl; (c) cycloalkyl of up to 6 carbon atoms which is optionally substituted on one or more carbon atoms thereof with, independently for each occurrence: (i) a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms which is optionally substituted with a halogen; or (ii) halogen; (d) a bridged bicyclo alkyl of the formula: where n, m and p are independently 1 to 3 and the sum of n+m+p is 6 or less, and wherein any of the ring carbon atoms may optionally be substituted with a a linear, branched, or cycloalkyl moiety comprising up to 6 carbon atoms; or (e) aryl of the formula: wherein, independently: A 2 is -H, -Br, or -F; A 3 is -H, -Cl, -Br, or -F; A 4 is -H, -Cl, -CH 3 , -Br, or -F. A 2 is -H, -Br, or -F; A 3 is -H, -Cl, -Br, or -F; A 4 is -H, -Cl, -CH 3 , -Br, or -F. <EOS>