A medical image processing apparatus , comprising: a division unit configured to divide a brain included in a first brain image (B1) of a subject into a plurality of regions by performing registration between the first brain image (B1) including a brain of a subject and a standard brain image (Bs) divided into a plurality of regions; a registration unit configured to perform registration between the first brain image of the subject (B1) and a second brain image (B2) that includes the brain of the same subject but has a different imaging date and time from the first brain image (B1); and a change amount acquisition unit configured to acquire an amount of change from a corresponding region in the brain included in the first brain image (B1), for at least one region of the plurality of regions in the brain included in the second brain image (B2), based on a result of the registration between the first brain image (B1) and the second brain image (B2); characterised in that the division unit is configured to perform a second registration between the first brain image (B1) and the standard brain image (Bs) after performing a first registration using landmarks between the first brain image (B1) and the standard brain image (B2), the registration unit is configured to perform a fourth registration between the first brain image (B1) and the second brain image (B2) after performing a third registration using landmarks between the first brain image (B1) and the second brain image (B2), the first registration is registration by parallel movement, rotation, and similar enlargement and reduction of the standard brain image (Bs), and the third registration is registration by parallel movement and rotation a division unit configured to divide a brain included in a first brain image (B1) of a subject into a plurality of regions by performing registration between the first brain image (B1) including a brain of a subject and a standard brain image (Bs) divided into a plurality of regions; a registration unit configured to perform registration between the first brain image of the subject (B1) and a second brain image (B2) that includes the brain of the same subject but has a different imaging date and time from the first brain image (B1); and a change amount acquisition unit configured to acquire an amount of change from a corresponding region in the brain included in the first brain image (B1), for at least one region of the plurality of regions in the brain included in the second brain image (B2), based on a result of the registration between the first brain image (B1) and the second brain image (B2); characterised in that the division unit is configured to perform a second registration between the first brain image (B1) and the standard brain image (Bs) after performing a first registration using landmarks between the first brain image (B1) and the standard brain image (B2), the registration unit is configured to perform a fourth registration between the first brain image (B1) and the second brain image (B2) after performing a third registration using landmarks between the first brain image (B1) and the second brain image (B2), the first registration is registration by parallel movement, rotation, and similar enlargement and reduction of the standard brain image (Bs), and the third registration is registration by parallel movement and rotation <EOS>