A dosimetry system for determining a presence/distribution of cross-linking agent in corneal tissue , comprising: one or more light sources configured to generate excitation light delivered to the corneal tissue treated with a the cross-linking agent , the excitation light causing the cross-linking agent to fluoresce by emitting an emission light at a plurality of emission wavelengths; an image capture system configured to employ hyperspectral imaging to capture an image of the corneal tissue in response to the delivery of the excitation light to the corneal tissue , wherein the image shows at least two emission wavelengths (λ 1 , λ 2 ) emitted by the corneal tissue and each of the at least two of the emission wavelengths (λ 1 , λ 2 ) can be identified from the image; and a controller configured to receive the image of the corneal tissue , the controller including one or more processors and computer-readable storage media, the one or more processors configured to execute program instructions stored on the computer-readable storage media to: identify and distinguish each of the at least two emission wavelengths (λ 1 , λ 2 ) in the image; determine, from the image, respective characteristics associated separately with each of the at least two emission wavelengths (λ 1 , λ 2 ); and provide information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths (λ 1 , λ 2 ). one or more light sources configured to generate excitation light delivered to the corneal tissue treated with a the cross-linking agent , the excitation light causing the cross-linking agent to fluoresce by emitting an emission light at a plurality of emission wavelengths; an image capture system configured to employ hyperspectral imaging to capture an image of the corneal tissue in response to the delivery of the excitation light to the corneal tissue , wherein the image shows at least two emission wavelengths (λ 1 , λ 2 ) emitted by the corneal tissue and each of the at least two of the emission wavelengths (λ 1 , λ 2 ) can be identified from the image; and a controller configured to receive the image of the corneal tissue , the controller including one or more processors and computer-readable storage media, the one or more processors configured to execute program instructions stored on the computer-readable storage media to: identify and distinguish each of the at least two emission wavelengths (λ 1 , λ 2 ) in the image; determine, from the image, respective characteristics associated separately with each of the at least two emission wavelengths (λ 1 , λ 2 ); and provide information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths (λ 1 , λ 2 ). identify and distinguish each of the at least two emission wavelengths (λ 1 , λ 2 ) in the image; determine, from the image, respective characteristics associated separately with each of the at least two emission wavelengths (λ 1 , λ 2 ); and provide information relating to cross-linking activity generated by the cross-linking agent in the corneal tissue based on the respective characteristics associated with each of the at least two emission wavelengths (λ 1 , λ 2 ). <EOS>