mhurhangee/patent-ind-claim-en huggingface dataset:
A method of producing an electrical feedthrough (200: 400) assembly for an implantable medical device, the method comprising: providing an outer ferrule of metallic material with an outer surface adapted to be sealed to an implantable device housing; producing an inner feedthrough assembly including: i. providing, by a 3D printing process, ceramic insulator material to form an electrical insulator , ii. providing, by the 3D printing process, one or more electrically conductive vias of metallized conductive material embedded within and extending through the electrical insulator , and iii. sintering the ceramic insulator material and the one or more electrically conductive layers to form a hermetic boundary that includes a transition interface region around each of the conductive vias comprising a gradient mixture of the ceramic insulator material and the metallized conductive material forming a gradual transition and a mechanical bond between the electrical insulator and the conductive via ; locating the inner feedthrough assembly within the outer ferrule ; and forming a hermetic seal between the inner feedthrough assembly and the outer ferrule . providing an outer ferrule of metallic material with an outer surface adapted to be sealed to an implantable device housing; producing an inner feedthrough assembly including: i. providing, by a 3D printing process, ceramic insulator material to form an electrical insulator , ii. providing, by the 3D printing process, one or more electrically conductive vias of metallized conductive material embedded within and extending through the electrical insulator , and iii. sintering the ceramic insulator material and the one or more electrically conductive layers to form a hermetic boundary that includes a transition interface region around each of the conductive vias comprising a gradient mixture of the ceramic insulator material and the metallized conductive material forming a gradual transition and a mechanical bond between the electrical insulator and the conductive via ; i. providing, by a 3D printing process, ceramic insulator material to form an electrical insulator , ii. providing, by the 3D printing process, one or more electrically conductive vias of metallized conductive material embedded within and extending through the electrical insulator , and iii. sintering the ceramic insulator material and the one or more electrically conductive layers to form a hermetic boundary that includes a transition interface region around each of the conductive vias comprising a gradient mixture of the ceramic insulator material and the metallized conductive material forming a gradual transition and a mechanical bond between the electrical insulator and the conductive via ; locating the inner feedthrough assembly within the outer ferrule ; and forming a hermetic seal between the inner feedthrough assembly and the outer ferrule .
A negative pressure therapy system for inducing negative pressure into the renal pelvis and/or kidneys of a patient, the system comprising: a. at least one ureteral catheter configured to be positioned within a ureter and/or kidney of a patient; b. one or more sensor(s) configured to determine information about urine produced within a urinary tract of the patient; c. a pump assembly for imparting negative pressure to the renal pelvis and/or kidneys of the patient; d. a controller being configured to increase urine production of the patient by adjusting one or more operating parameters of the pump assembly , based at least in part upon the information determined by the one or more sensor(s). a. at least one ureteral catheter configured to be positioned within a ureter and/or kidney of a patient; b. one or more sensor(s) configured to determine information about urine produced within a urinary tract of the patient; c. a pump assembly for imparting negative pressure to the renal pelvis and/or kidneys of the patient; d. a controller being configured to increase urine production of the patient by adjusting one or more operating parameters of the pump assembly , based at least in part upon the information determined by the one or more sensor(s).
Voltage presence determination system intended to be connected to a voltage measurement sensor for at least one phase of a high-voltage electrical network, the system comprising, for said at least one phase : - a visual indicator of the presence of a voltage measured by the voltage measurement sensor , referred to as the measured voltage, - a first output terminal configured to receive a first output signal which is representative of the measured voltage in terms of phase angle and amplitude, - a second output terminal configured to receive a second output signal which is representative of the measured voltage in terms of phase angle and amplitude, and - a plurality of linear components , the first and second output terminals being connected downstream of the visual indicator , the system being configured so that the first and second output terminals are functionally isolated from one another and functionally isolated from the visual indicator only by the plurality of linear components. - a visual indicator of the presence of a voltage measured by the voltage measurement sensor , referred to as the measured voltage, - a first output terminal configured to receive a first output signal which is representative of the measured voltage in terms of phase angle and amplitude, - a second output terminal configured to receive a second output signal which is representative of the measured voltage in terms of phase angle and amplitude, and - a plurality of linear components , the first and second output terminals being connected downstream of the visual indicator , the system being configured so that the first and second output terminals are functionally isolated from one another and functionally isolated from the visual indicator only by the plurality of linear components.
A composition for topical administration comprising: a liposomal concentrate in combination with at least one pharmaceutically acceptable carrier possessing at least one permeation enhancer which is ethoxydiglycol; wherein the liposomal concentrate comprises: a phospholipid selected from the group consisting of lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, phosphatidylserine, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidic acid, lysophosphatidylserine, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, and combinations thereof; at least one bioactive agent which is Coenzyme Q10; and at least one solubilizer; and wherein the composition comprises Coenzyme Q10 in an amount of from 1.25% to 5% by weight of the composition and ethoxydiglycol in an amount of from 2% by weight to 8% by weight of the composition. a liposomal concentrate in combination with at least one pharmaceutically acceptable carrier possessing at least one permeation enhancer which is ethoxydiglycol; wherein the liposomal concentrate comprises: a phospholipid selected from the group consisting of lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, phosphatidylserine, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidic acid, lysophosphatidylserine, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, and combinations thereof; at least one bioactive agent which is Coenzyme Q10; and at least one solubilizer; and a phospholipid selected from the group consisting of lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylglycerol, phosphatidic acid, phosphatidylserine, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidic acid, lysophosphatidylserine, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, and combinations thereof; at least one bioactive agent which is Coenzyme Q10; and at least one solubilizer; and wherein the composition comprises Coenzyme Q10 in an amount of from 1.25% to 5% by weight of the composition and ethoxydiglycol in an amount of from 2% by weight to 8% by weight of the composition.
An anode assembly for sacrificial anode based cathodic protection of reinforced concrete , the anode assembly comprising (i) a sacrificial anode , (ii) an electrically conductive layer , and (iii) an electrolytic material , wherein - the electrically conductive layer is configured for providing at a surface of the reinforced concrete to be protected, - the electrolytic material is connected to the electrically conductive layer , - the electrolytic material electrolytically connects the sacrificial anode to the electrically conductive layer . - the electrically conductive layer is configured for providing at a surface of the reinforced concrete to be protected, - the electrolytic material is connected to the electrically conductive layer , - the electrolytic material electrolytically connects the sacrificial anode to the electrically conductive layer .
A therapeutic composition comprising (a) chimeric antigen receptor-expressing T-cells (CAR T-cells) and a pharmaceutically acceptable excipient, and (b) either early apoptotic cells or an early apoptotic cell supernatant, and a pharmaceutically acceptable excipient, wherein said CAR T-cells and said either early apoptotic cells or said early apoptotic cell supernatant are premixed in the same composition or are comprised in separate compositions, wherein analysis of said early apoptotic cells demonstrates staining with Annexin V and not with propidium iodide (PI).
A process for preparing a quinolone compound comprising the step of reacting a des-chloro quinolone compound or a pharmaceutically acceptable salt or ester thereof with a chlorinating agent and an acid, wherein the molar ratio of the acid to des-chloro quinolone is from about 0.008 to about 0.012, wherein the acid is sulfuric acid and the chlorinating agent is N -chlorosuccinimide, and wherein less than about 0.40% of dimeric impurity on an area percent basis of the quinolone is produced, wherein the quinolone compound is 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt or ester thereof and the des-chloro quinolone compound is 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-hydroxy-azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt or ester thereof, and wherein the dimeric impurity is 1-amino-3-(azetidin-3-yloxy)-propan-2-ol-bis( N,N' -quinolone carboxylic acid), or a pharmaceutically acceptable salt or ester thereof.
A light emitting device comprising: a radiation source that radiates laser light as primary light ; a first wavelength converter that contains a first phosphor that absorbs at least part of the primary light radiated by the radiation source and converts the primary light absorbed into secondary light , wherein the first phosphor is sealed in an inorganic material other than organic materials; and a second wavelength converter that contains a second phosphor that absorbs at least part of the secondary light emitted by the first wavelength converter and converts the secondary light absorbed into tertiary light , wherein the first wavelength converter is located between the radiation source and the second wavelength converter and separate from the radiation source , the light emitting device emits output light containing the primary light , the secondary light , and the tertiary light , the secondary light contains a larger amount of long-wavelength component than the primary light , the tertiary light contains a larger amount of long-wavelength component than the secondary light , a lifetime of fluorescence emitted from the second phosphor is longer than a lifetime of fluorescence emitted from the first phosphor , and light density of the secondary light , with which the second wavelength converter is irradiated, is lower than light density of the primary light , with which the first wavelength converter is irradiated, characterised in that the first wavelength converter is separate from the second wavelength converter . a radiation source that radiates laser light as primary light ; a first wavelength converter that contains a first phosphor that absorbs at least part of the primary light radiated by the radiation source and converts the primary light absorbed into secondary light , wherein the first phosphor is sealed in an inorganic material other than organic materials; and a second wavelength converter that contains a second phosphor that absorbs at least part of the secondary light emitted by the first wavelength converter and converts the secondary light absorbed into tertiary light , wherein the first wavelength converter is located between the radiation source and the second wavelength converter and separate from the radiation source , the light emitting device emits output light containing the primary light , the secondary light , and the tertiary light , the secondary light contains a larger amount of long-wavelength component than the primary light , the tertiary light contains a larger amount of long-wavelength component than the secondary light , a lifetime of fluorescence emitted from the second phosphor is longer than a lifetime of fluorescence emitted from the first phosphor , and light density of the secondary light , with which the second wavelength converter is irradiated, is lower than light density of the primary light , with which the first wavelength converter is irradiated, characterised in that the first wavelength converter is separate from the second wavelength converter .
An indirect evaporative cooling system comprising: a frame ; a heat exchanger core disposed within the frame ; a supply fan supported by the frame to move indoor return air inside the heat exchanger core ; an outdoor exhaust fan supported by the frame to draw outdoor air over the heat exchanger core in a direction perpendicular to the indoor return air; a water spray system positioned above the heat exchanger core to spray water over the heat exchanger core ; a pump fluidly connected to the water spray system ; and a water collection and management system disposed within the frame below the heat exchanger core to collect water sprayed onto the heat exchanger core , the water collection and management system including a water basin configured to contain fluid, the water basin being configured to include an operational water volume and a water reserve volume which together define a total usable water volume, the water basin including a water height set point to define the water reserve volume, characterized in that the indirect evaporative cooling system is configured to determine the operation of the pump , and wherein the water collection and management system is configured to perform a blowdown only if the pump is determined to be operating, wherein the blowdown comprises draining the water from the water basin at a controlled rate such that only the water contained within the operational water volume is drained and the water contained within the reserve water volume is preserved. a frame ; a heat exchanger core disposed within the frame ; a supply fan supported by the frame to move indoor return air inside the heat exchanger core ; an outdoor exhaust fan supported by the frame to draw outdoor air over the heat exchanger core in a direction perpendicular to the indoor return air; a water spray system positioned above the heat exchanger core to spray water over the heat exchanger core ; a pump fluidly connected to the water spray system ; and a water collection and management system disposed within the frame below the heat exchanger core to collect water sprayed onto the heat exchanger core , the water collection and management system including a water basin configured to contain fluid, the water basin being configured to include an operational water volume and a water reserve volume which together define a total usable water volume, the water basin including a water height set point to define the water reserve volume, characterized in that the indirect evaporative cooling system is configured to determine the operation of the pump , and wherein the water collection and management system is configured to perform a blowdown only if the pump is determined to be operating, wherein the blowdown comprises draining the water from the water basin at a controlled rate such that only the water contained within the operational water volume is drained and the water contained within the reserve water volume is preserved.
A system for providing lift, propulsion, and control for Vertical take-off and landing (VTOL)/Short take-off and landing (STOL) operations of an aircraft vehicle , the system comprising: a. at least one airfoil extending from a leading edge to a trailing edge; b. a cross-flow fan rotor , having a rotation axis, at least partially embedded in the airfoil and substantially the same length as the airfoil and mounted adjacent to the trailing edge of the airfoil; and c. an exit duct for the cross-flow fan configured to provide distributed flow along the trailing edge of the airfoil and configured to provide vectored thrust; and the system further comprises: d. a flap arranged rotatable about the cross-flow fan rotation axis , where the flap has an upper face and a lower face , and characterized in that the airfoil includes a flexlip , with an upper face wherein the lower face of the flap and the upper face of the flexlip form the exit duct ; wherein the flap and the flexlip forming the exit duct are further configured to move simultaneously but at different angular rate to deliver a desired change in both the angle and mass flow of the vectored thrust. a. at least one airfoil extending from a leading edge to a trailing edge; b. a cross-flow fan rotor , having a rotation axis, at least partially embedded in the airfoil and substantially the same length as the airfoil and mounted adjacent to the trailing edge of the airfoil; and c. an exit duct for the cross-flow fan configured to provide distributed flow along the trailing edge of the airfoil and configured to provide vectored thrust; and the system further comprises: d. a flap arranged rotatable about the cross-flow fan rotation axis , where the flap has an upper face and a lower face , and
A method for managing streaming media service to a plurality of user devices disposed within an aircraft that is traveling along a predicted transport path through a multi-carrier communications system, the method comprising: computing, by a mobility management system , a congestion map to indicate congestion conditions for a plurality of carriers of the multi-carrier communications system along the predicted transport path, the congestion map indicating a first carrier as uncongested with respect to servicing the aircraft during a first service timeframe, and the congestion map indicating a second carrier as congested with respect to servicing the aircraft during a second service timeframe; identifying, by the mobility management system, candidate media content portions for consumption by one or more of the plurality of user devices during the second service timeframe, wherein the identifying is based at least in part on media content items presently provided to the one or more of the plurality of user devices within the aircraft via the multi-carrier communications system; selecting, by the mobility management system, a set of media content portions from the candidate media content portions that satisfy a pre-position threshold; and scheduling, by the mobility management system, transmission of the selected set of media content portions to the aircraft via the first carrier for storage local to the aircraft. computing, by a mobility management system , a congestion map to indicate congestion conditions for a plurality of carriers of the multi-carrier communications system along the predicted transport path, the congestion map indicating a first carrier as uncongested with respect to servicing the aircraft during a first service timeframe, and the congestion map indicating a second carrier as congested with respect to servicing the aircraft during a second service timeframe; identifying, by the mobility management system, candidate media content portions for consumption by one or more of the plurality of user devices during the second service timeframe, wherein the identifying is based at least in part on media content items presently provided to the one or more of the plurality of user devices within the aircraft via the multi-carrier communications system; selecting, by the mobility management system, a set of media content portions from the candidate media content portions that satisfy a pre-position threshold; and scheduling, by the mobility management system, transmission of the selected set of media content portions to the aircraft via the first carrier for storage local to the aircraft.
An apparatus comprising: a plurality of crypto cores; a capacitor connected across the plurality of crypto cores; and a current source including a plurality of current source blocks, the plurality of current source blocks including a respective current source block associated with each of the plurality of crypto cores; and wherein the plurality of current sources blocks are switchable to switch on a current source block associated with each active core of the plurality of crypto cores and to switch off a current source block associated with each inactive core of the plurality of crypto cores, wherein each current source block of the plurality of current source blocks is configured, in the case that the current source block is switched on, to operate in saturation mode to provide a fixed amount of current. a plurality of crypto cores; a capacitor connected across the plurality of crypto cores; and a current source including a plurality of current source blocks, the plurality of current source blocks including a respective current source block associated with each of the plurality of crypto cores; and wherein the plurality of current sources blocks are switchable to switch on a current source block associated with each active core of the plurality of crypto cores and to switch off a current source block associated with each inactive core of the plurality of crypto cores, wherein each current source block of the plurality of current source blocks is configured, in the case that the current source block is switched on, to operate in saturation mode to provide a fixed amount of current.