mhurhangee/patent-ind-claim-en huggingface dataset:
A method for additive fabrication using a device comprising a build platform and an imaging device, the method comprising: forming at least a portion of an object via additive fabrication; scanning a surface region of the at least a portion of the object with the imaging device; determining a depth map of a surface region of the at least a portion of the object; and forming a second portion of the object in contact with the first portion , said forming based at least in part on the determined depth map of the surface region of the first portion of the object, wherein: said scanning a surface region includes sensing the surface region of the object being fabricated for determining if less or more material has been formed than intended; and said forming the second portion includes forming at least one subsequent layer, wherein the formation of material of said at least one subsequent layer is adjusted such that additional material is provided in said at least one subsequent layer in response to said sensing, if less material has been formed than intended , characterized in that less material is provided in said at least one subsequent layer in response to said sensing, if more material has been formed than intended . forming at least a portion of an object via additive fabrication; scanning a surface region of the at least a portion of the object with the imaging device; determining a depth map of a surface region of the at least a portion of the object; and forming a second portion of the object in contact with the first portion , said forming based at least in part on the determined depth map of the surface region of the first portion of the object, said scanning a surface region includes sensing the surface region of the object being fabricated for determining if less or more material has been formed than intended; and said forming the second portion includes forming at least one subsequent layer, wherein the formation of material of said at least one subsequent layer is adjusted such that additional material is provided in said at least one subsequent layer in response to said sensing, if less material has been formed than intended , characterized in that less material is provided in said at least one subsequent layer in response to said sensing, if more material has been formed than intended .
A valve arrangement for a pressurized fluid source , the valve arrangement comprising: a valve housing comprising an inlet , an outlet , and a main fluid channel extending along a longitudinal axis of the valve housing; a spool located in the main fluid channel, the spool configured to translate along the longitudinal axis of the valve housing; a poppet valve located around the spool, the poppet valve configured to translate along the longitudinal axis of the valve housing; and a fluid feed channel , characterised in that the fluid feed channel is fluidly disconnected from the inlet of the valve housing when the spool is in a closed position, the fluid feed channel is fluidly connected with the inlet of the valve housing when the spool is in an open position, the outlet is fluidly connected with the inlet of the valve housing by the fluid feed channel when the spool is in the open position, and the poppet valve regulates a flow of a fluid from the inlet to the outlet when the spool is in the open position. a valve housing comprising an inlet , an outlet , and a main fluid channel extending along a longitudinal axis of the valve housing; a spool located in the main fluid channel, the spool configured to translate along the longitudinal axis of the valve housing; a poppet valve located around the spool, the poppet valve configured to translate along the longitudinal axis of the valve housing; and a fluid feed channel , characterised in that the fluid feed channel is fluidly disconnected from the inlet of the valve housing when the spool is in a closed position, the fluid feed channel is fluidly connected with the inlet of the valve housing when the spool is in an open position, the outlet is fluidly connected with the inlet of the valve housing by the fluid feed channel when the spool is in the open position, and the poppet valve regulates a flow of a fluid from the inlet to the outlet when the spool is in the open position. the fluid feed channel is fluidly disconnected from the inlet of the valve housing when the spool is in a closed position, the fluid feed channel is fluidly connected with the inlet of the valve housing when the spool is in an open position, the outlet is fluidly connected with the inlet of the valve housing by the fluid feed channel when the spool is in the open position, and the poppet valve regulates a flow of a fluid from the inlet to the outlet when the spool is in the open position.
A method for parallel processing of a plurality of biological cellular samples for producing cellular samples for cell therapy comprising: i) transferring a plurality of cellular samples (S1 to Sn) to a first processing unit (U1) containing a plurality of identical processing stations (P1/1 to P1/n), wherein each of said plurality of cellular samples (S1 to Sn) is contained in a respective sterile container; ii) processing each of said cellular samples (S1 to Sn) on a processing station (P1/1 to P1/n) to produce a plurality of processed cellular samples (S1/1 to Sn/1); iii) transferring said processed cellular samples (S1/1 to Sn/1) to a second processing unit (U2) containing a plurality of identical processing stations (P2/1 to P2/n); iv) processing each of said cellular samples (S1/1 to Sn/1) on a processing station (P2/1 to P2/n) to produce a plurality of processed cellular samples (S 1/2 to Sn/2); and v) transferring to and further processing said plurality of processed cellular samples on one or more processing units (UN) to produce a plurality of processed cellular samples (S1/N to Sn/N), the method being characterised in that the processing of the cellular samples involves one or more processes selected from the group consisting of cell isolation, cell concentration, cell culture, cell expansion, cell transduction and cell formulation, and wherein a unit for long duration processes contains more processing stations than a unit for short duration processes, and further characterised by maintaining an identity custody chain by recording component unique identities at each stage of processing transfer of processed patient material. i) transferring a plurality of cellular samples (S1 to Sn) to a first processing unit (U1) containing a plurality of identical processing stations (P1/1 to P1/n), wherein each of said plurality of cellular samples (S1 to Sn) is contained in a respective sterile container; ii) processing each of said cellular samples (S1 to Sn) on a processing station (P1/1 to P1/n) to produce a plurality of processed cellular samples (S1/1 to Sn/1); iii) transferring said processed cellular samples (S1/1 to Sn/1) to a second processing unit (U2) containing a plurality of identical processing stations (P2/1 to P2/n); iv) processing each of said cellular samples (S1/1 to Sn/1) on a processing station (P2/1 to P2/n) to produce a plurality of processed cellular samples (S 1/2 to Sn/2); and v) transferring to and further processing said plurality of processed cellular samples on one or more processing units (UN) to produce a plurality of processed cellular samples (S1/N to Sn/N),
A biopolymer composition comprising: a) 85 to 99.9 weight percent of one or more biopolymers, wherein said biopolymer comprises at least one synthetic biopolymer selected from the group consisting of polylactide and polyhydroxy butyrate and wherein said polylactide, polyhydroxy butyrate, or a mixture thereof comprise from 30-99.9 weight percent of total biopolymer composition; and b) 0.1 to 15 weight percent of one or more acrylic copolymers having a weight average molecular weight in the range of 10,000 to 3,000,000 g/mol, wherein said acrylic copolymers having 60 percent or more of acrylic and/or methacrylic monomer units and up to 40 percent of other ethylenically unsaturated monomers polymerizable with the acrylic monomers, including, but not limited to styrene, alpha-methyl styrene, butadiene, vinyl acetate, vinylidene fluorides, vinylidene chlorides, acrylonitrile, vinyl sulfone, vinyl sulfides, and vinyl suloxides; wherein biopolymer refers to a single biopolymer or a mixture of two or more biopolymers, denoting natural polymers, polymers synthesized from natural products and by-products and biodegradable polymers and wherein the acrylic copolymer is made from conventional polymerization techniques chosen from mass, bulk, solution, suspension, emulsion and inverse emulsion polymerization and wherein the acrylic copolymer is a blend of two or more copolymers, one copolymer with molecular weight greater than 500000 g/mol and one with a molecular weight less than 500000 g/mol. a) 85 to 99.9 weight percent of one or more biopolymers, wherein said biopolymer comprises at least one synthetic biopolymer selected from the group consisting of polylactide and polyhydroxy butyrate and wherein said polylactide, polyhydroxy butyrate, or a mixture thereof comprise from 30-99.9 weight percent of total biopolymer composition; and b) 0.1 to 15 weight percent of one or more acrylic copolymers having a weight average molecular weight in the range of 10,000 to 3,000,000 g/mol, wherein said acrylic copolymers having 60 percent or more of acrylic and/or methacrylic monomer units and up to 40 percent of other ethylenically unsaturated monomers polymerizable with the acrylic monomers, including, but not limited to styrene, alpha-methyl styrene, butadiene, vinyl acetate, vinylidene fluorides, vinylidene chlorides, acrylonitrile, vinyl sulfone, vinyl sulfides, and vinyl suloxides;
A method of enhancing efficiency of molecular inversion probe (MIP) ligation, the method comprising: a) providing a MIP comprising: a first homology region (HR1) comprising a first sequence complementary to a target nucleic acid of interest, and a second homology region (HR2) comprising in order: a second sequence complementary to the target nucleic acid of interest, a cleavage substrate base, and a removable nucleic acid region comprising a one or more nucleotide base sequence of the first sequence; b) contacting the MIP to the target nucleic acid of interest, thereby hybridizing the HR2 to the target nucleic acid and blocking HR1 hybridization due to interference from the removable nucleic acid region; c) contacting the hybridized MIP with an enzyme having an activity of cutting the MIP at the cleavage substrate base if the HR2 is hybridized to the target, thus releasing the removable nucleic acid region and allowing the HR1 to hybridize to the target nucleic acid; and, d) ligating HR1 to that part of HR2 that remains. a) providing a MIP comprising: a first homology region (HR1) comprising a first sequence complementary to a target nucleic acid of interest, and a second homology region (HR2) comprising in order: a second sequence complementary to the target nucleic acid of interest, a cleavage substrate base, and a removable nucleic acid region comprising a one or more nucleotide base sequence of the first sequence; a first homology region (HR1) comprising a first sequence complementary to a target nucleic acid of interest, and a second homology region (HR2) comprising in order: a second sequence complementary to the target nucleic acid of interest, a cleavage substrate base, and a removable nucleic acid region comprising a one or more nucleotide base sequence of the first sequence; b) contacting the MIP to the target nucleic acid of interest, thereby hybridizing the HR2 to the target nucleic acid and blocking HR1 hybridization due to interference from the removable nucleic acid region; c) contacting the hybridized MIP with an enzyme having an activity of cutting the MIP at the cleavage substrate base if the HR2 is hybridized to the target, thus releasing the removable nucleic acid region and allowing the HR1 to hybridize to the target nucleic acid; and, d) ligating HR1 to that part of HR2 that remains.
An immunogenic composition comprising an immunologically effective amount of at least one antigenic polysaccharide, an immunologically effective amount of at least one peptide or polypeptide antigen, and at least one pair of affinity molecules, wherein the or each pair comprises a first affinity molecule and a second affinity molecule complementary to the first affinity molecule, wherein, in the or each pair: the first affinity molecule is associated with one of the at least one antigenic polysaccharides, and the complementary second affinity molecule is associated with one of the at least one peptide or polypeptide antigens, and the or each first affinity molecule non-covalently associates with the or each complementary second affinity molecule to link the peptide or polypeptide antigen(s) and the antigenic polysaccharide(s); and wherein the immunogenic composition can elicit (i) an immune response to the at least one antigenic polysaccharide, and (ii) an immune response to the at least one peptide or polypeptide antigen, in a subject following administration of the composition to the subject. the first affinity molecule is associated with one of the at least one antigenic polysaccharides, and the complementary second affinity molecule is associated with one of the at least one peptide or polypeptide antigens, and the or each first affinity molecule non-covalently associates with the or each complementary second affinity molecule to link the peptide or polypeptide antigen(s) and the antigenic polysaccharide(s); and wherein the immunogenic composition can elicit (i) an immune response to the at least one antigenic polysaccharide, and (ii) an immune response to the at least one peptide or polypeptide antigen, in a subject following administration of the composition to the subject.
A computer-based method for managing services provided by a service provider, the computer-based method comprising: receiving a service order at a workflow engine ; identifying an identified workflow from a plurality of workflows corresponding to the service order ; sending a ready-to-activate service order and data to a provisioning engine ; assembling a command at the provisioning engine, in a format that is specific to a network element , to perform the ready-to-activate service order; the provisioning engine receiving a response to the network element-specific command from the network element at the provisioning engine ; parsing the response at the provisioning engine ; returning the parsed response to the workflow engine ; and sending the network element-specific command from the provisioning engine to the network element, wherein each workflow of the plurality of workflows comprises a start event and a plurality of structured activities and tasks executed sequentially and in parallel and/or conditionally producing a specific service. receiving a service order at a workflow engine ; identifying an identified workflow from a plurality of workflows corresponding to the service order ; sending a ready-to-activate service order and data to a provisioning engine ; assembling a command at the provisioning engine, in a format that is specific to a network element , to perform the ready-to-activate service order; the provisioning engine receiving a response to the network element-specific command from the network element at the provisioning engine ; parsing the response at the provisioning engine ; returning the parsed response to the workflow engine ; and sending the network element-specific command from the provisioning engine to the network element, wherein each workflow of the plurality of workflows comprises a start event and a plurality of structured activities and tasks executed sequentially and in parallel and/or conditionally producing a specific service.
A method, comprising: receiving, by a processor , respective coordinates for multiple points on a three-dimensional surface, wherein the three-dimensional surface is representative of tissue in a body cavity; rendering an image of the surface on a display screen ; and for each given point among the multiple points , computing a density of the points within a region surrounding the given point, and rendering, on the display screen , the given point on the surface with a point size that is inversely related to the computed density. receiving, by a processor , respective coordinates for multiple points on a three-dimensional surface, wherein the three-dimensional surface is representative of tissue in a body cavity; rendering an image of the surface on a display screen ; and for each given point among the multiple points , computing a density of the points within a region surrounding the given point, and rendering, on the display screen , the given point on the surface with a point size that is inversely related to the computed density.
An illumination apparatus comprising: a light source having a light emitting surface configured to emit light in a surface shape by using a semiconductor light emitting element; and an optical element which has a shape rotationally symmetrical with respect to an axis line (O1) along a direction that passes through the center of gravity (O') of the light emitting surface to intersect at right angles with the light emitting surface and which transmits the light of the light source , wherein the optical element comprises a through-hole provided along the axis line (O1), an entrance surface which faces the light emitting surface and in which the through-hole is open, an exit surface extending in a direction to depart from the light source to surround the axis line from the outer circumferential edge of the entrance surface a total reflection surface which connects the distal edge of the exit surface and the inner circumferential edge of the entrance surface facing the through-hole to define the through-hole , the total reflection surface being configured to totally reflect, toward the exit surface , the light of the light source that has entered the optical element from the entrance surface characterized in that the exit surface is approaching the axis line as departing from the light source . a light source having a light emitting surface configured to emit light in a surface shape by using a semiconductor light emitting element; and an optical element which has a shape rotationally symmetrical with respect to an axis line (O1) along a direction that passes through the center of gravity (O') of the light emitting surface to intersect at right angles with the light emitting surface and which transmits the light of the light source , wherein the optical element comprises a through-hole provided along the axis line (O1), an entrance surface which faces the light emitting surface and in which the through-hole is open, an exit surface extending in a direction to depart from the light source to surround the axis line from the outer circumferential edge of the entrance surface a total reflection surface which connects the distal edge of the exit surface and the inner circumferential edge of the entrance surface facing the through-hole to define the through-hole , the total reflection surface being configured to totally reflect, toward the exit surface , the light of the light source that has entered the optical element from the entrance surface characterized in that the exit surface is approaching the axis line as departing from the light source .
A trigger for a weapon, the weapon comprising a sear disconnected from the trigger, the trigger comprises: - a lever mechanically coupled by one end to the trigger , the lever comprising a contact surface that causes rotation of the sear; - a carrier ; - an actuator that actuates the carrier ; - a first magnetic element established on the lever ; and - a second magnetic element established on the carrier , wherein at least the first magnetic element or the second magnetic element is a magnet or an electromagnet, wherein the trigger comprises: a firing state, wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element attract each other, and wherein the attraction between the first magnetic element and the second magnetic element causes the connection of the trigger and the sear through the contact surface of the lever allowing a shot to be fired when pulling the trigger; and a safe state, wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element do not attract each other, wherein the lack of attraction between the first magnetic element and the second magnetic element avoids the connection of the trigger and the sear impeding a shot to be fired when pulling the trigger. - a lever mechanically coupled by one end to the trigger , the lever comprising a contact surface that causes rotation of the sear; - a carrier ; - an actuator that actuates the carrier ; - a first magnetic element established on the lever ; and - a second magnetic element established on the carrier , a firing state, wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element attract each other, and wherein the attraction between the first magnetic element and the second magnetic element causes the connection of the trigger and the sear through the contact surface of the lever allowing a shot to be fired when pulling the trigger; and wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element attract each other, and wherein the attraction between the first magnetic element and the second magnetic element causes the connection of the trigger and the sear through the contact surface of the lever allowing a shot to be fired when pulling the trigger; and a safe state, wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element do not attract each other, wherein the lack of attraction between the first magnetic element and the second magnetic element avoids the connection of the trigger and the sear impeding a shot to be fired when pulling the trigger. wherein the actuator actuates the carrier such that the first magnetic element and the second magnetic element do not attract each other, wherein the lack of attraction between the first magnetic element and the second magnetic element avoids the connection of the trigger and the sear impeding a shot to be fired when pulling the trigger.