A compound of Formula V or VA: or a pharmaceutically acceptable salt thereof; wherein m is 0, 1, 2 or 3; r is 0, 1, 2 or 3; Cy2 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, carbocyclic and substituted carbocyclic; L 1 is absent or C 1 -C 3 -alkyl; each R 2 is selected from hydrogen, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aliphatic, substituted aliphatic, aryl and substituted aryl, -OR 100 , -NR 100 R 101 , -C(O)R 100 , -C(O)OR 100 , -C(O)NR 100 R 101 , - N(R 100 )C(O)R 101 , -S(O) 2 R 100 , -S(O)R 100 , -SR 100 , -S(O) 2 N(R 100 )R 101 , -CF 3 , -CN, -NO 2 , and -N 3 ;R 200 is R 100 or -N(R 100 )(R 101 ); R 5 is hydrogen; and each R 100 and R 101 is selected from alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl; wherein each substituted group is substituted by one or more groups selected from halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, aralkoxycarbonyl, carboxylic acid, sulfonic acid, sulfonyl, phosphonic acid, aryl, and heteroaryl. m is 0, 1, 2 or 3; r is 0, 1, 2 or 3; Cy2 is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, carbocyclic and substituted carbocyclic; L 1 is absent or C 1 -C 3 -alkyl; each R 2 is selected from hydrogen, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aliphatic, substituted aliphatic, aryl and substituted aryl, -OR 100 , -NR 100 R 101 , -C(O)R 100 , -C(O)OR 100 , -C(O)NR 100 R 101 , - N(R 100 )C(O)R 101 , -S(O) 2 R 100 , -S(O)R 100 , -SR 100 , -S(O) 2 N(R 100 )R 101 , -CF 3 , -CN, -NO 2 , and -N 3 ;R 200 is R 100 or -N(R 100 )(R 101 ); R 5 is hydrogen; and each R 100 and R 101 is selected from alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl; wherein each substituted group is substituted by one or more groups selected from halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, trifluoromethyl, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, aralkoxycarbonyl, carboxylic acid, sulfonic acid, sulfonyl, phosphonic acid, aryl, and heteroaryl. <EOS>