mhurhangee/patent-ind-claim-en huggingface dataset:
A recombinant Factor VIII protein comprising at least three amino acid substitutions at positions selected from the group consisting of Y748, L171, S507, N79, I80, I105, S112, L160, V184, N233, L235, V257, I265, N299, Y426, Y430, L505, F555, 1610, N616, I632, L706, N754, K1837, R1936, S2030, S2037, N2038, S2077, M2123, S2125, F2215, K2226, K2258, V2313, S2315, V2333 and Q2335; wherein substitutions of N are independently selected from the group consisting of D, H, S and E; wherein substitution of I are independently selected from the group consisting of T and V; wherein substitutions of S are independently selected from the group consisting of A, N, G, T and E; wherein substitutions of L are independently selected from the group consisting of N, Q, F and S; wherein substitutions of V are independently selected from the group consisting of A and T; wherein substitutions of Y are independently selected from the group consisting of N, H and S; wherein substitutions of F are independently selected from the group consisting of H and S; wherein substitutions of K are independently selected from the group consisting of N, D, E, Q, S and T; wherein substitutions of R are independently selected from the group consisting of Q, H and S; wherein substitutions of M are selected from the group consisting of R, Q, K and T; and/or wherein substitutions of Q are selected from the group consisting of R, D, E, H and K; wherein the positions are specified in relation to full length human Factor VIII molecule of SEQ ID NO: 1; and wherein the recombinant Factor VIII protein retains at least 50% coagulant activity, as determined in a chromogenic assay, compared to a Factor VIII protein consisting of SEQ ID NO: 2, or a fusion protein of said recombinant Factor VIII protein. wherein substitutions of N are independently selected from the group consisting of D, H, S and E; wherein substitution of I are independently selected from the group consisting of T and V; wherein substitutions of S are independently selected from the group consisting of A, N, G, T and E; wherein substitutions of L are independently selected from the group consisting of N, Q, F and S; wherein substitutions of V are independently selected from the group consisting of A and T; wherein substitutions of Y are independently selected from the group consisting of N, H and S; wherein substitutions of F are independently selected from the group consisting of H and S; wherein substitutions of K are independently selected from the group consisting of N, D, E, Q, S and T; wherein substitutions of R are independently selected from the group consisting of Q, H and S; wherein substitutions of M are selected from the group consisting of R, Q, K and T; and/or wherein substitutions of Q are selected from the group consisting of R, D, E, H and K; wherein the positions are specified in relation to full length human Factor VIII molecule of SEQ ID NO: 1; and wherein the recombinant Factor VIII protein retains at least 50% coagulant activity, as determined in a chromogenic assay, compared to a Factor VIII protein consisting of SEQ ID NO: 2, or a fusion protein of said recombinant Factor VIII protein.
A pharmaceutically acceptable esylate or oxalate salt of 5-(2-(8-Oxa-3-azabicyclo[octan-3-yl)-9-(pentan-3-yl)-9Hpurine-6-yl)pyrazin-2-amine.
A double clad optical fiber having a waveguide core , an inner waveguide cladding around the core having an inner cladding refractive index , and an outer waveguide cladding around the inner cladding , the outer waveguide cladding being a fluoroacrylate cladding and having an outer cladding refractive index lower than the inner cladding refractive index , and a jacket around the outer waveguide cladding having a jacket refractive index, the optical fiber having a portion extending along its length along which the outer waveguide cladding and the jacket are absent, the portion having corresponding faces of the outer waveguide cladding at two lengthwisely opposite ends of the portion , characterized in that said optical fiber has a sealant at said portion , said sealant extending along the entire length of the portion , the sealant impeding lengthwise diffusion of environmental water through both faces into the outer waveguide cladding .
An orthopaedic joint prosthesis assembly which comprises: a. a head part of an orthopaedic joint prosthesis component, which has a spherical bearing surface (6; 104) for articulation with a corresponding joint surface, and an assembly surface (8; 108) having a first bore (5; 106) formed in it for receiving a spigot on another part of the orthopaedic joint prosthesis, said bore having a first axis that extends perpendicular to the assembly surface, and in which there is a discontinuity (8a; 108a) at an interface between the bearing surface and the assembly surface, the said assembly surface being arranged on a plane which is parallel to, or contains, a plane which is defined by the opening to the bore in the head part when the head part is viewed from one side in cross-section, and b. an alignment guide (10; 110) comprising an axial portion (11; 112) and an arm (16a, 16b; 114; 116) extending from the axial portion, the arm including a distal portion (22a, 22b; 134) and a proximal portion (20a, 20b; 132), the axial portion defining a second axis and being arranged to engage the bearing surface of the head part, directly or indirectly, when the head part is mounted within the guide, characterised in that the distal portion of the arm is configured to engage the assembly surface of the head part, with the second axis coincident with the first axis, such when an impaction force is applied along the second axis the force is directed along the first axis. a. a head part of an orthopaedic joint prosthesis component, which has a spherical bearing surface (6; 104) for articulation with a corresponding joint surface, and an assembly surface (8; 108) having a first bore (5; 106) formed in it for receiving a spigot on another part of the orthopaedic joint prosthesis, said bore having a first axis that extends perpendicular to the assembly surface, and in which there is a discontinuity (8a; 108a) at an interface between the bearing surface and the assembly surface, the said assembly surface being arranged on a plane which is parallel to, or contains, a plane which is defined by the opening to the bore in the head part when the head part is viewed from one side in cross-section, and b. an alignment guide (10; 110) comprising an axial portion (11; 112) and an arm (16a, 16b; 114; 116) extending from the axial portion, the arm including a distal portion (22a, 22b; 134) and a proximal portion (20a, 20b; 132), the axial portion defining a second axis and being arranged to engage the bearing surface of the head part, directly or indirectly, when the head part is mounted within the guide, characterised in that the distal portion of the arm is configured to engage the assembly surface of the head part, with the second axis coincident with the first axis, such when an impaction force is applied along the second axis the force is directed along the first axis.
A suspension coil spring that is mounted between an upper seat and a lower seat in a strut suspension for an automobile, comprising: an upper end turn that sits on the upper seat ; a spring active portion that includes one or more coils; and a lower end turn that sits on the lower seat , while substantially contacting the lower seat at a single lower contacting point (P3) that is positioned at the automobile outer side with respect to a center point (CML) of the lower end turn , said suspension coil spring being characterized in that : each coil is formed such that a portion whose curvature is the largest is positioned at an automobile outer side under a mounted state, the upper end turn is provided to be substantially symmetrical with respect to a line segment (RLU) that passes on a center position (CMU) of the upper end turn and extends in a right-left direction of the automobile, and the upper end turn sits on the upper seat while substantially contacting the upper seat at two upper contacting points (P1, P2) that are provided to be apart from each other in a front-back direction of the automobile. an upper end turn that sits on the upper seat ; a spring active portion that includes one or more coils; and a lower end turn that sits on the lower seat , while substantially contacting the lower seat at a single lower contacting point (P3) that is positioned at the automobile outer side with respect to a center point (CML) of the lower end turn , said suspension coil spring being characterized in that : each coil is formed such that a portion whose curvature is the largest is positioned at an automobile outer side under a mounted state, the upper end turn is provided to be substantially symmetrical with respect to a line segment (RLU) that passes on a center position (CMU) of the upper end turn and extends in a right-left direction of the automobile, and the upper end turn sits on the upper seat while substantially contacting the upper seat at two upper contacting points (P1, P2) that are provided to be apart from each other in a front-back direction of the automobile. each coil is formed such that a portion whose curvature is the largest is positioned at an automobile outer side under a mounted state, the upper end turn is provided to be substantially symmetrical with respect to a line segment (RLU) that passes on a center position (CMU) of the upper end turn and extends in a right-left direction of the automobile, and the upper end turn sits on the upper seat while substantially contacting the upper seat at two upper contacting points (P1, P2) that are provided to be apart from each other in a front-back direction of the automobile.
A lighting module for a speculum comprising: a housing portion ; a clip portion comprising a receiving space for receiving an upper portion of a window frame of the speculum , an opening of the window frame forming a viewing window when a top bill and a bottom bill of the speculum are in an open position, the clip portion configured to be clipped to the upper portion of the window frame of the speculum when the upper portion of the window frame of the speculum is received by the clip portion ; an arm portion extending from the clip portion and comprising a light emitting diode at a distal end of the arm portion , the arm portion insertable through the viewing window formed by the window frame between the top bill and the bottom bill, a length of the arm portion forming an angle with a length of the clip portion so that the arm portion is configured to extend from the clip portion and be disposed against an inner surface of the top bill of the speculum ; a power source contained in the housing portion electrically connected to the light emitting diode ; and an activation mechanism for activating the light emitting diode by providing power to the light emitting diode . a housing portion ; a clip portion comprising a receiving space for receiving an upper portion of a window frame of the speculum , an opening of the window frame forming a viewing window when a top bill and a bottom bill of the speculum are in an open position, the clip portion configured to be clipped to the upper portion of the window frame of the speculum when the upper portion of the window frame of the speculum is received by the clip portion ; an arm portion extending from the clip portion and comprising a light emitting diode at a distal end of the arm portion , the arm portion insertable through the viewing window formed by the window frame between the top bill and the bottom bill, a length of the arm portion forming an angle with a length of the clip portion so that the arm portion is configured to extend from the clip portion and be disposed against an inner surface of the top bill of the speculum ; a power source contained in the housing portion electrically connected to the light emitting diode ; and an activation mechanism for activating the light emitting diode by providing power to the light emitting diode .
Method for testing the die-attach of a photovoltaic cell assembly comprising the steps of: providing a photovoltaic cell assembly comprising at least one photovoltaic cell, in particular a concentrator photovoltaic cell, attached to a heat sink; injecting a current into the photovoltaic cell assembly ; measuring the voltage across said at least one photovoltaic cell during the current injection ; and determining the relative voltage drop over the duration of the current injection . providing a photovoltaic cell assembly comprising at least one photovoltaic cell, in particular a concentrator photovoltaic cell, attached to a heat sink; injecting a current into the photovoltaic cell assembly ; measuring the voltage across said at least one photovoltaic cell during the current injection ; and determining the relative voltage drop over the duration of the current injection .
A method of controlling an elevator door dwell time, the method comprising: obtaining a predefined load weight value ; obtaining a load weight value from a load weight sensor coupled to an elevator car ; comparing the load weight value to the predefined load weight value to generate a difference; and adjusting the elevator door dwell time in response to the difference to define an adjusted elevator door dwell time, characterized in that the adjusting comprises decreasing the elevator door dwell time when the load weight value is less than the predefined load weight value . obtaining a predefined load weight value ; obtaining a load weight value from a load weight sensor coupled to an elevator car ; comparing the load weight value to the predefined load weight value to generate a difference; and adjusting the elevator door dwell time in response to the difference to define an adjusted elevator door dwell time, characterized in that the adjusting comprises decreasing the elevator door dwell time when the load weight value is less than the predefined load weight value .
A method of providing access control, AC, in respect of a database storing information, where the database is configured to accept a database query and return information extracted from the database, the method being implemented at least in part at a policy enforcement point, PEP, which is located between the database and a database client, and comprising: i) intercepting, at the PEP, query to the database; ii) assigning at least one attribute value based on the query or on information relating to the entity submitting the query; iii) providing an attributed-based AC policy defined in terms of said attributes; iv) deriving an access condition, for which the AC policy, when evaluated for the attribute value(s) assigned in step ii), evaluates to permit access; and v) amending the database query by imposing said access condition; and vi) transmitting the amended query to the database. i) intercepting, at the PEP, query to the database; ii) assigning at least one attribute value based on the query or on information relating to the entity submitting the query; iii) providing an attributed-based AC policy defined in terms of said attributes; iv) deriving an access condition, for which the AC policy, when evaluated for the attribute value(s) assigned in step ii), evaluates to permit access; and v) amending the database query by imposing said access condition; and vi) transmitting the amended query to the database.
A liquid formulation for use in therapy, comprising: 10 to 100 mg/ml of aflibercept; a buffer including a histidine salt and having pH ranging from 5.7 to 6.2, wherein the histidine salt is 10 mM to 50 mM of histidine-HCl or histidine-acetate; 2.5% (w/v) to 10% (w/v) of sugar selected from the group consisting of trehalose, sucrose, mannitol and glucose; and 0% (v/v) to 0.03% (v/v) of surfactant selected from the group consisting of polysorbate 20 and polysorbate 80, wherein the formulation does not contain additional salt ingredients. 10 to 100 mg/ml of aflibercept; a buffer including a histidine salt and having pH ranging from 5.7 to 6.2, wherein the histidine salt is 10 mM to 50 mM of histidine-HCl or histidine-acetate; 2.5% (w/v) to 10% (w/v) of sugar selected from the group consisting of trehalose, sucrose, mannitol and glucose; and 0% (v/v) to 0.03% (v/v) of surfactant selected from the group consisting of polysorbate 20 and polysorbate 80, wherein the formulation does not contain additional salt ingredients.
A method for producing an expanded granulate made of a sand grain-shaped mineral material using a propellant, e.g. an expanded granulate of perlite or obsidian sand; wherein the material is fed to a substantially upright furnace ; wherein the material is conveyed along a conveying path through a plurality of vertically separated heating zones in a furnace shaft of the furnace , wherein each heating zone can be heated by at least one independently controllable heating element ; wherein the material is heated to a critical temperature at which the surfaces of the sand grains become plastic and the sand grains are expanded through the propellant; wherein the expanded material is discharged from the furnace , characterized in that the material is fed together with an amount of air from below, wherein the material is conveyed from bottom to top along the conveying path by means of the amount of air which flows from bottom to top within the furnace shaft and forms an air flow , and wherein the expanding of the sand grains occurs in the upper half, preferably in the uppermost third, of the conveying path .
A compound of formula (II), or a stereoisomer, a crystalline polymorph, a solvate, or a pharmaceutically acceptable salt or ester thereof: wherein R a is R b is R c is (CH 3 ) 2 CHCH 2 -; R d is H 2 N(CH 2 ) 3 CH 2 -; and is substituted with one or more W groups, wherein the W group is selected from -(CH 2 ) n OH, HOCH 2 (CHOH) n CH 2 -, (HOCH 2 ) 2 CH-, (HOCH 2 ) 3 C-, -(CH 2 ) n NH 2 , -(C(R 4 ) 2 ) i CON(R 5 ) 2 , -(C(R 4 ) 2 ) i CO 2 R 5 , C 3-6 monosaccharide, polysaccharide composed of 2-20 same or different C 3-6 monosaccharide, and R 3 O(CH 2 CH 2 O) m CH 2 CH 2 -; R 2 is selected from H, NH 2 CH 2 CH 2 -, NH 2 (CH 2 ) 2 CH 2 - and HOOCCH 2 -; R 1 is selected from: R 3 is selected from C 1-4 alkyl; if present, each R 4 is independently selected from H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-10 cycloalkyl, 3-10-membered heterocyclic group, C 6-10 aryl and 5-14-membered heteroaryl; optionally, if present, each R 4 is independently selected from H, halogen and C 1-4 alkyl; optionally, R 4 is H; if present, each R 5 is H; if present, each i is independently an integer from 0 to 6, optionally from 1 to 5, optionally from 1 to 2; if present, each n is independently an integer from 1 to 8, optionally 1 to 5, optionally from 1 to 3; and, m is an integer from 1 to 20. R a is R b is R c is (CH 3 ) 2 CHCH 2 -; R d is H 2 N(CH 2 ) 3 CH 2 -; and is substituted with one or more W groups, wherein the W group is selected from -(CH 2 ) n OH, HOCH 2 (CHOH) n CH 2 -, (HOCH 2 ) 2 CH-, (HOCH 2 ) 3 C-, -(CH 2 ) n NH 2 , -(C(R 4 ) 2 ) i CON(R 5 ) 2 , -(C(R 4 ) 2 ) i CO 2 R 5 , C 3-6 monosaccharide, polysaccharide composed of 2-20 same or different C 3-6 monosaccharide, and R 3 O(CH 2 CH 2 O) m CH 2 CH 2 -; R 2 is selected from H, NH 2 CH 2 CH 2 -, NH 2 (CH 2 ) 2 CH 2 - and HOOCCH 2 -; R 1 is selected from: R 3 is selected from C 1-4 alkyl; if present, each R 4 is independently selected from H, halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 3-10 cycloalkyl, 3-10-membered heterocyclic group, C 6-10 aryl and 5-14-membered heteroaryl; optionally, if present, each R 4 is independently selected from H, halogen and C 1-4 alkyl; optionally, R 4 is H; if present, each R 5 is H; if present, each i is independently an integer from 0 to 6, optionally from 1 to 5, optionally from 1 to 2; if present, each n is independently an integer from 1 to 8, optionally 1 to 5, optionally from 1 to 3; and, m is an integer from 1 to 20.
An organic LED element , comprising: a transparent substrate ; a light scattering layer formed on the transparent substrate; a transparent first electrode formed on the light scattering layer; an organic light-emitting layer formed on the first electrode; and a second electrode formed on the organic light-emitting layer, wherein the light scattering layer has a base material comprising a glass, and a plurality of scattering materials dispersed in the base material, and the light scattering layer has a bottom surface on the transparent substrate side, an upper surface on the first electrode side and side surfaces, and each of the side surfaces of the light scattering layer has a surface tilted at an angle larger than right angle from the upper surface toward the bottom surface, characterised in that the first electrode is placed so as to continuously cover the side surfaces of the light scattering layer .
A method for generating a beacon signal to be used in determining a position and/or orientation of an object, the method comprising: causing a first coil to generate a first magnetic field and a second coil to generate a second magnetic field, at least in part by: controlling a first driver , comprising a first switching amplifier having first transistors (T 1 , T 2 ) and further comprising a first capacitor (Cx) coupled to the first coil , with a first binary control signal (V X ) to operate the first driver off-resonance, controlling a second driver , comprising a second switching amplifier having second transistors (T 3 , T 4 ) and further comprising a second capacitor (C Y ) coupled to the second coil , with a second binary input signal (V y ) to operate the second driver off-resonance; and coupling the first and second drivers to a supply rail (V DD ) in a gradual manner with an activation circuit having a ramped response such that the first and second drivers are activated gradually. causing a first coil to generate a first magnetic field and a second coil to generate a second magnetic field, at least in part by: controlling a first driver , comprising a first switching amplifier having first transistors (T 1 , T 2 ) and further comprising a first capacitor (Cx) coupled to the first coil , with a first binary control signal (V X ) to operate the first driver off-resonance, controlling a second driver , comprising a second switching amplifier having second transistors (T 3 , T 4 ) and further comprising a second capacitor (C Y ) coupled to the second coil , with a second binary input signal (V y ) to operate the second driver off-resonance; and coupling the first and second drivers to a supply rail (V DD ) in a gradual manner with an activation circuit having a ramped response such that the first and second drivers are activated gradually. controlling a first driver , comprising a first switching amplifier having first transistors (T 1 , T 2 ) and further comprising a first capacitor (Cx) coupled to the first coil , with a first binary control signal (V X ) to operate the first driver off-resonance, controlling a second driver , comprising a second switching amplifier having second transistors (T 3 , T 4 ) and further comprising a second capacitor (C Y ) coupled to the second coil , with a second binary input signal (V y ) to operate the second driver off-resonance; and coupling the first and second drivers to a supply rail (V DD ) in a gradual manner with an activation circuit having a ramped response such that the first and second drivers are activated gradually.