A portable surgical system comprising: a) a flexible enclosure separating a surgical environment inside the enclosure from an user environment outside the enclosure, the enclosure comprising: an incise drape incorporated into the bottom of an operating-section of the enclosure and configured to be disposed on or around a surgical site of a patient's body and to expose the surgical site, wherein the size and shape of the incise drape is configured to cover the surgical site on the patient's body; one or more areas of high optical clarity for viewing the inside of the enclosure; and a flexible tube receiving air from an environmental control system and configured to create essentially uniform and constant airflow over the surgical site through manifold air outlets ; wherein, while the surgical system is deployed in use, only the surgical site covered by the drape is included within the surgical enclosure, and the remainder of the patient body is essentially excluded from the surgical environment inside the enclosure; b) the environmental control system configured to supply air to the enclosure such as to create essentially sterile conditions inside the enclosure; and c) one or more ports for accessing the surgical site. a) a flexible enclosure separating a surgical environment inside the enclosure from an user environment outside the enclosure, the enclosure comprising: an incise drape incorporated into the bottom of an operating-section of the enclosure and configured to be disposed on or around a surgical site of a patient's body and to expose the surgical site, wherein the size and shape of the incise drape is configured to cover the surgical site on the patient's body; one or more areas of high optical clarity for viewing the inside of the enclosure; and a flexible tube receiving air from an environmental control system and configured to create essentially uniform and constant airflow over the surgical site through manifold air outlets ; wherein, while the surgical system is deployed in use, only the surgical site covered by the drape is included within the surgical enclosure, and the remainder of the patient body is essentially excluded from the surgical environment inside the enclosure; an incise drape incorporated into the bottom of an operating-section of the enclosure and configured to be disposed on or around a surgical site of a patient's body and to expose the surgical site, wherein the size and shape of the incise drape is configured to cover the surgical site on the patient's body; one or more areas of high optical clarity for viewing the inside of the enclosure; and a flexible tube receiving air from an environmental control system and configured to create essentially uniform and constant airflow over the surgical site through manifold air outlets ; wherein, while the surgical system is deployed in use, only the surgical site covered by the drape is included within the surgical enclosure, and the remainder of the patient body is essentially excluded from the surgical environment inside the enclosure; b) the environmental control system configured to supply air to the enclosure such as to create essentially sterile conditions inside the enclosure; and c) one or more ports for accessing the surgical site. <EOS>