A T-cell receptor (TCR) which is specific for the epitope located between positions 293-312 in the GAG protein of HIV-1 having the amino-acid sequence FRDYVDRF[Y/F]KTLRAEQA[S/T]QE (SEQ ID NO: 1) when presented as a peptide-MHC II complex, comprising an alpha chain and a beta chain whose variable domains each comprise three complementarity determining regions CDR1, CDR2 and CDR3, wherein a. the amino-acid sequence of the CDR1 and CDR2 on the alpha variable chain is encoded by the human TRAV24 gene, where the amino-acid sequence for the CDR1 alpha is the amino-acid sequence corresponding to the positions 49 to 54 in SEQ ID NO: 58 and the amino-acid sequence for the CDR2alpha is the amino-acid sequence corresponding to the positions 72 to 77 in SEQ ID NO: 58, and b. the amino-acid sequence of the CDR1 and CDR2 on the beta variable chain is encoded by the human TRBV2 gene, where the amino-acid sequence for the CDR1beta is the amino-acid sequence corresponding to the positions 46 to 50 in SEQ ID NO: 59 and the amino-acid sequence for the CDR2beta is the amino-acid sequence corresponding to the positions 68 to 73 in SEQ ID NO: 59, and c. the amino-acid sequence of the CDR3 on the alpha chain comprises a motif selected amongst: [A/S]X[K/R]AAGNKLT (SEQ ID NO: 2), AXYGGATNKLI (SEQ ID NO: 3), AX[R/N][R/N]AGNMLTF (SEQ ID NO: 4), AXD[N/D]RKLI (SEQ ID NO: 5) or AXE[S/G]X[G/A][A/S][Q/E]KLV (SEQ ID NO: 6), X being any amino-acid, and d. the amino-acid sequence of the CDR3 on the beta chain comprises a motif selected amongst: ASSX[R/G/L][T/A][S/G]GXX[E/D/T][Q/T][F/Y]) (SEQ ID NO: 7), ASSX[R/G/L][T/A][S/G/A]GXX[E/D/T/P][Q/T][F/Y/H] (SEQ ID NO: 8), ASSGXXNTEAF (SEQ ID NO: 9) or ASVLMRT[N/R]NEQF (SEQ ID NO: 10), X being any amino-acid, wherein the TCR has an affinity for the epitope located between positions 293-312 of the GAG protein of HIV-1 measured by a Kd value that is equal or less than 20 μM by SPR analysis and in particular that is equal or less than 10 μM, more particularly equal or less than 1 μM, more particularly between the range of 0.5 to 7 μM, especially the range of 0.5 to 1 μM. a. the amino-acid sequence of the CDR1 and CDR2 on the alpha variable chain is encoded by the human TRAV24 gene, where the amino-acid sequence for the CDR1 alpha is the amino-acid sequence corresponding to the positions 49 to 54 in SEQ ID NO: 58 and the amino-acid sequence for the CDR2alpha is the amino-acid sequence corresponding to the positions 72 to 77 in SEQ ID NO: 58, and b. the amino-acid sequence of the CDR1 and CDR2 on the beta variable chain is encoded by the human TRBV2 gene, where the amino-acid sequence for the CDR1beta is the amino-acid sequence corresponding to the positions 46 to 50 in SEQ ID NO: 59 and the amino-acid sequence for the CDR2beta is the amino-acid sequence corresponding to the positions 68 to 73 in SEQ ID NO: 59, and c. the amino-acid sequence of the CDR3 on the alpha chain comprises a motif selected amongst: [A/S]X[K/R]AAGNKLT (SEQ ID NO: 2), AXYGGATNKLI (SEQ ID NO: 3), AX[R/N][R/N]AGNMLTF (SEQ ID NO: 4), AXD[N/D]RKLI (SEQ ID NO: 5) or AXE[S/G]X[G/A][A/S][Q/E]KLV (SEQ ID NO: 6), X being any amino-acid, and d. the amino-acid sequence of the CDR3 on the beta chain comprises a motif selected amongst: ASSX[R/G/L][T/A][S/G]GXX[E/D/T][Q/T][F/Y]) (SEQ ID NO: 7), ASSX[R/G/L][T/A][S/G/A]GXX[E/D/T/P][Q/T][F/Y/H] (SEQ ID NO: 8), ASSGXXNTEAF (SEQ ID NO: 9) or ASVLMRT[N/R]NEQF (SEQ ID NO: 10), X being any amino-acid, wherein the TCR has an affinity for the epitope located between positions 293-312 of the GAG protein of HIV-1 measured by a Kd value that is equal or less than 20 μM by SPR analysis and in particular that is equal or less than 10 μM, more particularly equal or less than 1 μM, more particularly between the range of 0.5 to 7 μM, especially the range of 0.5 to 1 μM. <EOS>