mhurhangee/patent-ind-claim-en huggingface dataset:
Composition consisting of (i) Bacterial Ghosts derived from E. coli Nissle 1917, (ii) optionally an active agent, wherein the active agent is a chemotherapeutic drug, selected from doxorubicin, oxaliplatin, resveratrol, epirubicin, idarubicin, mitoxantrone, cyclophosphamide, maphosphamide, bortezomib or bleomycin, and (iii) a pharmaceutically acceptable carrier and/or excipient for use in the treatment or prevention of cancer. (i) Bacterial Ghosts derived from E. coli Nissle 1917, (ii) optionally an active agent, wherein the active agent is a chemotherapeutic drug, selected from doxorubicin, oxaliplatin, resveratrol, epirubicin, idarubicin, mitoxantrone, cyclophosphamide, maphosphamide, bortezomib or bleomycin, and (iii) a pharmaceutically acceptable carrier and/or excipient for use in the treatment or prevention of cancer.
A method of producing combined heat and power, the method comprising the steps of: providing a cupola for containing a metal bath delivering a feedstock to the cupola, operating an inductive element (125; 506) to react with the metal bath to generate syngas, generating heat and power by use of the syngas, supplementing said step of operating an inductive element by performing the further step of operating a plasma torch , wherein the plasma torch is configured to operate on the metal bath indirectly. providing a cupola for containing a metal bath delivering a feedstock to the cupola, operating an inductive element (125; 506) to react with the metal bath to generate syngas, generating heat and power by use of the syngas, supplementing said step of operating an inductive element by performing the further step of operating a plasma torch , wherein the plasma torch is configured to operate on the metal bath indirectly.
A composite board made of wood material with a middle layer made of plywood, wherein the middle layer is connected to at least one outer layer made of fiberboard, characterized in that a synthetic resin-saturated paper is arranged between the middle layer and outer layer.
A method of diagnosing an allograft rejection (AR) in an individual who has received or will receive an organ transplant, the method comprising the steps of: a) isolating one antibody from a biological sample from the individual that forms an affinity interaction with at least a portion or peptide fragment of CTLA4, and optionally isolating at least one further antibody from the biological sample from an individual that forms an affinity interaction with at least a portion or peptide fragment at least one protein selected from the group consisting of TRIM21, HSH2D, IFI6, APEX2, CLIP4, UBXD8, ZMYM5, EDIL3, UBE2V1, PHGDH, SCEL, ZCCHC8, C22orf33, CPSF3, C20orf96, ENG, DLG3, GAK, CDC42EP3, ARFGAP1, XIAP, C2orf47, QKI, ICAM4, FLT3LG, DRICH1, PDDC1, FOXP1, NUDT16L1, UBQLN2, TOX2, AFF4, CWF19L2, GCDH, FAM184A, SUMO1, CHGB, ZNF695, LMX1A, CPLX2, MYOT, SNX13, CSPP1, GYG2, ODF2, TADA3, AQP2, DMD, GOLGA2P10, MUTED, PRELP, HLA-DPA1, and TSSK2, b) measuring the level of the at least one antibody, and optionally the level of the at least one further antibody, c) comparing the level of the at least one antibody, and optionally the level of the at least one further antibody, from the individual to a positive reference standard and comparing the level of the at least one antibody, and optionally the level of the at least one further antibody, to a negative reference; and wherein a similarity of the measured level of the at least one antibody, and optionally the measured level of the at least one further antibody, to the positive reference standard indicates increased risk of developing AR and a similarity of the measured level of the at least one antibody, and optionally the measured level of the at least one further antibody, to the negative reference standard indicates reduced risk of developing AR. a) isolating one antibody from a biological sample from the individual that forms an affinity interaction with at least a portion or peptide fragment of CTLA4, and optionally isolating at least one further antibody from the biological sample from an individual that forms an affinity interaction with at least a portion or peptide fragment at least one protein selected from the group consisting of TRIM21, HSH2D, IFI6, APEX2, CLIP4, UBXD8, ZMYM5, EDIL3, UBE2V1, PHGDH, SCEL, ZCCHC8, C22orf33, CPSF3, C20orf96, ENG, DLG3, GAK, CDC42EP3, ARFGAP1, XIAP, C2orf47, QKI, ICAM4, FLT3LG, DRICH1, PDDC1, FOXP1, NUDT16L1, UBQLN2, TOX2, AFF4, CWF19L2, GCDH, FAM184A, SUMO1, CHGB, ZNF695, LMX1A, CPLX2, MYOT, SNX13, CSPP1, GYG2, ODF2, TADA3, AQP2, DMD, GOLGA2P10, MUTED, PRELP, HLA-DPA1, and TSSK2, b) measuring the level of the at least one antibody, and optionally the level of the at least one further antibody, c) comparing the level of the at least one antibody, and optionally the level of the at least one further antibody, from the individual to a positive reference standard and comparing the level of the at least one antibody, and optionally the level of the at least one further antibody, to a negative reference; and
Punch riveting device for connecting at least two components , having a punch , a dolly , a holding-down means and a vibration generator , wherein the punch , the holding-down means and the dolly are arranged with respect to one another such that the at least two components are arrangeable between the punch and the dolly and at the same time between the holding-down means and the dolly , wherein the punch and the vibration generator are coupled together and form a vibrating system , wherein a drive is provided, to which the punch and the holding-down means are coupled such that, by means of the drive , a force (F) is able to be exerted on the punch and on the holding-down means in the direction of the components , characterized in that the vibration generator is configured as an ultrasound generator, wherein the holding-down means is coupled to the vibrating system such that a vibration amplitude (A) of the holding-down means in the contact region with one of the components exhibits at most 25%, in particular at most 10%, of a vibration amplitude (A) of the punch in the contact region with a rivet , wherein the holding-down means is coupled to the vibrating system in a region of the vibrating system in which a vibration amplitude (A) of the vibrating system exhibits at most 10%, in particular at most 5%, of the vibration amplitude (A) of the punch in the contact region with the rivet .
A hopper container, particularly for bulk materials, which has a floor , a lock , and a frame in which walls are fixed, two of the walls having in their lower section two oblique plates leaning toward the floor , wherein the floor consists of at least one set made of at least two flaps , the flaps are pivotally mounted on mounting beams , and the flaps are connected from the bottom via pivotal elements to at least one release beam , wherein said release beam is connected by its one end to the lock , which is connected to an arm seated on an axis that extends along one of the walls, and wherein said lock is separably connected to a locking lever of the lock , characterised in that a grate is placed above the flaps .
Vaccine for reducing infection by avian Reovirus, the vaccine comprising avian Reovirus antigenic material that is derived from avian Reoviruses from more than a single genotype group, and a pharmaceutically acceptable carrier, wherein the avian Reovirus antigenic material consists of inactivated avian Reoviruses from each one of two genotype groups: genotype group 1 and genotype group 4; wherein an avian Reovirus belonging to genotype group 1 contains genetic information encoding a sigmaC protein having an amino acid sequence that has at least 75 % amino acid sequence identity with the amino acid sequence of SEQ ID NO. 1.; wherein an avian Reovirus belonging to genotype group 4 contains genetic information encoding a sigmaC protein having an amino acid sequence that has at least 75 % amino acid sequence identity with the amino acid sequence of SEQ ID NO. 4; and wherein the vaccine comprises an adjuvant.
Method to control a steer-by-wire steering system of a road vehicle, wherein the steer-by-wire steering system comprises a road wheel actuator for turning of steerable road wheels , a steering wheel actuator for applying a feedback torque to a steering wheel , characterized in that the method includes the following steps: • Calculating the feedback torque by modifying a base steering torque as a function of a longitudinal and lateral acceleration measured by vehicle's sensors to account for a weight transfer of the vehicle, wherein in case of lateral acceleration of the vehicle the feedback torque will be direction independently higher compared to zero absolute lateral acceleration; • Sending the calculated feedback torque to the steering wheel actuator to give feedback to the driver at the steering wheel . • Calculating the feedback torque by modifying a base steering torque as a function of a longitudinal and lateral acceleration measured by vehicle's sensors to account for a weight transfer of the vehicle, wherein in case of lateral acceleration of the vehicle the feedback torque will be direction independently higher compared to zero absolute lateral acceleration; • Sending the calculated feedback torque to the steering wheel actuator to give feedback to the driver at the steering wheel .
A composition comprising a polyol crosslinked with a) a multifunctional epoxide; or b) an epihalohydrin; or c) a molecule or crosslinker mixture comprising multiple epihalohydrin and/or epoxide groups or molecules; and wherein the composition has a number N 1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule, the remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N 2 of pendant groups per crosslinker molecule, among the N 2 groups per crosslinker there are N 3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles, the relationship between N 1 and N 2 is: N 1 > 0.35 (N 1 + N 2 ), characterized in that A) the composition comprises a multitude of interconnected pores; B) the composition is characterized by a fractured structure comprising a multitude of individual sponge particles; and C) the particles have a number of protrusions at their surfaces. a) a multifunctional epoxide; or b) an epihalohydrin; or c) a molecule or crosslinker mixture comprising multiple epihalohydrin and/or epoxide groups or molecules; and wherein the composition has a number N 1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule, the remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N 2 of pendant groups per crosslinker molecule, among the N 2 groups per crosslinker there are N 3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles, the relationship between N 1 and N 2 is: N 1 > 0.35 (N 1 + N 2 ), characterized in that A) the composition comprises a multitude of interconnected pores; B) the composition is characterized by a fractured structure comprising a multitude of individual sponge particles; and C) the particles have a number of protrusions at their surfaces. and wherein the composition has a number N 1 of effective ether crosslinks per crosslinker molecule as calculated by subtracting 1 from the average number of distinct polyol repeat units bound per crosslinker molecule, the remaining reactive groups on the crosslinker are ineffective in crosslinking and provide a number N 2 of pendant groups per crosslinker molecule, among the N 2 groups per crosslinker there are N 3 groups per crosslinker that are unreacted or otherwise retain reactivity against nucleophiles, the relationship between N 1 and N 2 is: N 1 > 0.35 (N 1 + N 2 ), characterized in that A) the composition comprises a multitude of interconnected pores; B) the composition is characterized by a fractured structure comprising a multitude of individual sponge particles; and C) the particles have a number of protrusions at their surfaces.
An apparatus for fitting an earphone device in an ear canal , the apparatus comprising: • an anatomically shaped, compressible cushion member adapted to fit into an ear canal ; • a channel arranged in said cushion member extending from a first side to a second side , said channel comprising at least two opposing side walls , ∘ wherein said cushion member and said channel are ovally shaped, said channel comprising a first pair of opposing side walls defined by a smaller curvature and a second pair of opposing side walls defined by a larger curvature; • at least one spacer member extending from at least one of said side walls towards an opposing side wall , but not being connected to said opposing side wall , ∘ wherein said at least one spacer member is configured to provide a minimum clearance (C) between said opposing side walls to allow acoustic waves to traverse said channel from said first side to said second side in both a non-compressed state and a compressed state of said cushion member . • an anatomically shaped, compressible cushion member adapted to fit into an ear canal ; • a channel arranged in said cushion member extending from a first side to a second side , said channel comprising at least two opposing side walls , ∘ wherein said cushion member and said channel are ovally shaped, said channel comprising a first pair of opposing side walls defined by a smaller curvature and a second pair of opposing side walls defined by a larger curvature; ∘ wherein said cushion member and said channel are ovally shaped, said channel comprising a first pair of opposing side walls defined by a smaller curvature and a second pair of opposing side walls defined by a larger curvature; • at least one spacer member extending from at least one of said side walls towards an opposing side wall , but not being connected to said opposing side wall , ∘ wherein said at least one spacer member is configured to provide a minimum clearance (C) between said opposing side walls to allow acoustic waves to traverse said channel from said first side to said second side in both a non-compressed state and a compressed state of said cushion member . ∘ wherein said at least one spacer member is configured to provide a minimum clearance (C) between said opposing side walls to allow acoustic waves to traverse said channel from said first side to said second side in both a non-compressed state and a compressed state of said cushion member .
Method for at least partially extracting a mould core forming at least one undercut from an injection-moulding tool , wherein the mould core comprises an inner core and a number of segments (18.1 to 18.8) arranged around the inner core , wherein the inner core is moved along a central longitudinal axis of the mould core , wherein at least one group of first segments (18.1, 18.2, 18.7, 18.8) being moved in a movement direction perpendicular to the central longitudinal axis , and at least one group of second segments (18.3, 18.4, 18.5, 18.6) being moved in at least two movement directions on at least one plane , the vector of which is being arranged in parallel to the central longitudinal axis , wherein the movements into the at least two movement directions are in chronological order.
Method for creating an irradiation plan for irradiating a target volume area , moving in at least some areas, inside an object using a particle beam, the irradiation plan comprising irradiation points (B i ) which are approached by the particle beam in the course of irradiation and which each represent a set of control parameters for the particle beam, the method comprising the steps - Predefining a plurality of movement states (k) for the target volume area to be irradiated; - Determining the volume to be irradiated for each of the movement states (k); - Stipulating a plurality of target point volumes (V j ) in the target volume area moving in at least some areas; - Creating a mapping function between the irradiation points (B i ) and the target point volumes (V j ), the mapping function containing values which describe, for each of the plurality of movement states (k), the dose administered to at least one target point volume (V j ) when the i-th irradiation point (B i ) is approached; and - Creating the irradiation plan using the mapping function , characterized in that a substantially similar irradiation pattern is used to calculate the irradiation plan for a plurality of target point volumes (V j ) in differing movement states (k). - Predefining a plurality of movement states (k) for the target volume area to be irradiated; - Determining the volume to be irradiated for each of the movement states (k); - Stipulating a plurality of target point volumes (V j ) in the target volume area moving in at least some areas; - Creating a mapping function between the irradiation points (B i ) and the target point volumes (V j ), the mapping function containing values which describe, for each of the plurality of movement states (k), the dose administered to at least one target point volume (V j ) when the i-th irradiation point (B i ) is approached; and - Creating the irradiation plan using the mapping function ,
A compound common-path interferometer comprising: a first interferometer having a first measurement arm , a second interferometer having a second measurement arm , a base for supporting the first and second measurement arms , each of the first and second measurement arms including a reference optic and an optical pathway for conveying both a test beam from a test object and a reference beam from each of the reference optics , and a coupling between the reference optics of the first and second measurement arms forming together with the reference optics a monolithic measurement cavity for maintaining reference surfaces of the reference optics at a fixed spacing and orientation, characterized in that the reference optic of the first measurement arm is structurally disconnected from a rest of the first measurement arm for limiting transmission of disturbances between the reference optic of the first measurement arm and the rest of the first measurement arm , the reference optic of the second measurement arm is structurally disconnected from a rest of the second measurement arm for limiting transmission of disturbances between the reference optic of the second measurement arm and the rest of the second measurement arm , and the monolithic measurement cavity is connected to the base independently of the rest of the first measurement arm and independently of the rest of the second measurement arm , wherein the coupling between the reference optics of the first and second measurement arms includes a thermally stable spacer between the reference optics of the first and second measurement arms . a first interferometer having a first measurement arm , a second interferometer having a second measurement arm , a base for supporting the first and second measurement arms , each of the first and second measurement arms including a reference optic and an optical pathway for conveying both a test beam from a test object and a reference beam from each of the reference optics , and a coupling between the reference optics of the first and second measurement arms forming together with the reference optics a monolithic measurement cavity for maintaining reference surfaces of the reference optics at a fixed spacing and orientation, characterized in that the reference optic of the first measurement arm is structurally disconnected from a rest of the first measurement arm for limiting transmission of disturbances between the reference optic of the first measurement arm and the rest of the first measurement arm , the reference optic of the second measurement arm is structurally disconnected from a rest of the second measurement arm for limiting transmission of disturbances between the reference optic of the second measurement arm and the rest of the second measurement arm , and the monolithic measurement cavity is connected to the base independently of the rest of the first measurement arm and independently of the rest of the second measurement arm , wherein the coupling between the reference optics of the first and second measurement arms includes a thermally stable spacer between the reference optics of the first and second measurement arms .
A kit for correcting for variations in sample processing and/or biological matrix effects when performing biological assays, said kit comprising a normalization factor that does not bind an analyte from the biological sample to be assayed and that is coupled to a solid support, wherein the normalization factor is hFXIII, and a plurality of solid supports having binding members immobilize thereon that bind one or more analytes in the sample.
Hollow rotor shaft for a rotating electrical machine, the rotor shaft comprising two parts (Z11, Z12), wherein a first part (Z11) comprises a first hollow cylindrical element having a first end and a second end opposite the first end , and a second part (Z12) comprises a second hollow cylindrical element having a first end , wherein a first section (S1) of the first end of the first hollow cylindrical element and a second section (S2) of the first end of the second hollow cylindrical element are secured by securing means, characterised in that the first section (S1) of the first end of the first hollow cylindrical element and the second section (S2) of the first end of the second hollow cylindrical element are in contact and the securing means comprises: a plurality of first bosses regularly distributed over an internal periphery of the second end of the first hollow cylindrical element forming a first ring of bosses, each of the first bosses comprising a smooth guide hole , a plurality of second bosses regularly distributed over an internal periphery of the first end of the second hollow cylindrical element forming a second ring of bosses, each of the second bosses comprising a threaded hole , a fixation part at the second end of the first hollow cylindrical element and in contact with a section of the first ring of bosses, and a plurality of threaded elements , each threaded element passing through a respective guide hole , being screwed into a respective threaded hole and cooperating with the fixation part such that each threaded element is parallel to an axis of revolution of the rotor shaft and holds the first and second sections (S1, S2) in contact. a plurality of first bosses regularly distributed over an internal periphery of the second end of the first hollow cylindrical element forming a first ring of bosses, each of the first bosses comprising a smooth guide hole , a plurality of second bosses regularly distributed over an internal periphery of the first end of the second hollow cylindrical element forming a second ring of bosses, each of the second bosses comprising a threaded hole , a fixation part at the second end of the first hollow cylindrical element and in contact with a section of the first ring of bosses, and a plurality of threaded elements , each threaded element passing through a respective guide hole , being screwed into a respective threaded hole and cooperating with the fixation part such that each threaded element is parallel to an axis of revolution of the rotor shaft and holds the first and second sections (S1, S2) in contact.