An improved analyte detection sensor of a blood gas, electrolyte, and/or metabolite instrument, comprising: a substrate, the substrate comprising a top surface and a bottom surface; an enzyme layer, the enzyme layer comprising at least one enzyme, wherein the enzyme layer is disposed on the top surface of the substrate, and wherein the at least one enzyme is selected from the group consisting of creatininase, creatinase, sarcosine oxidase, and combination thereof; a scavenger protein layer capable of complexing and/or associating with the biocides, the scavenger protein layer comprising at least one scavenger protein having at least one free sulfhydryl functional group, wherein the scavenger protein layer is disposed on the top surface of the substrate such that the scavenger protein layer substantially covers an entirety of the enzyme layer; at least one electrode, wherein the at least one electrode is disposed on the top surface of the substrate such that the at least one electrode is substantially covered by the enzyme layer; and a sensor membrane cover, the sensor membrane being disposed over the scavenger protein layer, wherein the at least one analyte detection sensor comprises a creatinine detection sensor, and wherein the at least one scavenger protein of the scavenger protein layer is selected from the group consisting of bovine serum albumin, thioredoxin, urease, glutathione, cadystin, phytochelatin, homoglutathione, homophytochelatin, desGly peptide, desglycine phytochelatin, hydroxymethyl-glutathione, hydroxymethyl-phytochelatin, and combinations thereof, wherein the concentration of the at least one scavenger protein of the scavenger protein layer is from about 0.1 milligram per milliliter to about 50 milligrams per milliliter, wherein the analyte detection sensor is in fluid communication with a biocide preservation fluid. a substrate, the substrate comprising a top surface and a bottom surface; an enzyme layer, the enzyme layer comprising at least one enzyme, wherein the enzyme layer is disposed on the top surface of the substrate, and wherein the at least one enzyme is selected from the group consisting of creatininase, creatinase, sarcosine oxidase, and combination thereof; a scavenger protein layer capable of complexing and/or associating with the biocides, the scavenger protein layer comprising at least one scavenger protein having at least one free sulfhydryl functional group, wherein the scavenger protein layer is disposed on the top surface of the substrate such that the scavenger protein layer substantially covers an entirety of the enzyme layer; at least one electrode, wherein the at least one electrode is disposed on the top surface of the substrate such that the at least one electrode is substantially covered by the enzyme layer; and a sensor membrane cover, the sensor membrane being disposed over the scavenger protein layer, wherein the at least one analyte detection sensor comprises a creatinine detection sensor, and wherein the at least one scavenger protein of the scavenger protein layer is selected from the group consisting of bovine serum albumin, thioredoxin, urease, glutathione, cadystin, phytochelatin, homoglutathione, homophytochelatin, desGly peptide, desglycine phytochelatin, hydroxymethyl-glutathione, hydroxymethyl-phytochelatin, and combinations thereof, wherein the concentration of the at least one scavenger protein of the scavenger protein layer is from about 0.1 milligram per milliliter to about 50 milligrams per milliliter, wherein the analyte detection sensor is in fluid communication with a biocide preservation fluid. <EOS>