mhurhangee/patent-ind-claim-en huggingface dataset:
A process for the preparation of Lenvatinib of formula (I) which comprises: a) reacting 1 equivalent of 4-chloro-7-methoxyquinoline-6-carboxamide (VI) with 2 equivalents of the compound of formula (V) at a temperature ranging from 45°C to 55°C, in dimethylsulfoxide and in the presence of cesium carbonate to provide Lenvatinib (I); b) crystallizing Lenvatinib (I) in 1:3 dimethylsulfoxide : dichloromethane. a) reacting 1 equivalent of 4-chloro-7-methoxyquinoline-6-carboxamide (VI) with 2 equivalents of the compound of formula (V) at a temperature ranging from 45°C to 55°C, in dimethylsulfoxide and in the presence of cesium carbonate to provide Lenvatinib (I); b) crystallizing Lenvatinib (I) in 1:3 dimethylsulfoxide : dichloromethane.
An electronic device for rendering a high dynamic range, HDR, image comprising: a receiver configured to receive a compressed bitstream and metadata, the metadata comprising a plurality of blend factors for combining standard dynamic range, SDR, images depending on view directions; at least one processor configured to: obtain a first SDR image and a second SDR image by decoding the compressed bitstream; identify viewpoint information based on an orientation of the electronic device; identify a blend factor corresponding to the identified viewpoint information among the plurality of blend factors; obtain an HDR image by combining the first SDR image and the second SDR image based on the identified blend factor; and render a portion of the obtained HDR image based on the metadata and the viewpoint information; and a display configured to display the portion of the HDR image. a receiver configured to receive a compressed bitstream and metadata, the metadata comprising a plurality of blend factors for combining standard dynamic range, SDR, images depending on view directions; at least one processor configured to: obtain a first SDR image and a second SDR image by decoding the compressed bitstream; identify viewpoint information based on an orientation of the electronic device; identify a blend factor corresponding to the identified viewpoint information among the plurality of blend factors; obtain an HDR image by combining the first SDR image and the second SDR image based on the identified blend factor; and render a portion of the obtained HDR image based on the metadata and the viewpoint information; and obtain a first SDR image and a second SDR image by decoding the compressed bitstream; identify viewpoint information based on an orientation of the electronic device; identify a blend factor corresponding to the identified viewpoint information among the plurality of blend factors; obtain an HDR image by combining the first SDR image and the second SDR image based on the identified blend factor; and render a portion of the obtained HDR image based on the metadata and the viewpoint information; and a display configured to display the portion of the HDR image.
A neurostimulation lead comprising: a lead body having a proximal portion and a distal portion; a first conductor extending through the lead body ; and an electrode cuff secured relative to the distal portion of the lead body , the electrode cuff including: a cuff body having a first region and a second region ; a first tendril extending from the first region of the cuff body ; a second tendril extending from the second region of the cuff body ; and a first electrode disposed on the cuff body and electrically connected to the first conductor, wherein at least one of the first tendril and the second tendril is configured to overlap the cuff body . a lead body having a proximal portion and a distal portion; a first conductor extending through the lead body ; and an electrode cuff secured relative to the distal portion of the lead body , the electrode cuff including: a cuff body having a first region and a second region ; a first tendril extending from the first region of the cuff body ; a second tendril extending from the second region of the cuff body ; and a first electrode disposed on the cuff body and electrically connected to the first conductor, wherein at least one of the first tendril and the second tendril is configured to overlap the cuff body . a cuff body having a first region and a second region ; a first tendril extending from the first region of the cuff body ; a second tendril extending from the second region of the cuff body ; and a first electrode disposed on the cuff body and electrically connected to the first conductor, wherein at least one of the first tendril and the second tendril is configured to overlap the cuff body .
A naked antisense oligonucleotide for use in the treatment of a retinal disease caused by a mutation which modifies the splicing and/or creates a premature termination in a gene important to the functioning and/or the survival of a photoreceptor cell, in a subject in need thereof, wherein said naked antisense oligonucleotide is injected into the vitreous of the subject, wherein the naked antisense oligonucleotide performs antisense oligonucleotide-mediated exon skipping in the pre-mRNA from the gene which mutation causes the retinal disease, in a photoreceptor cell of the subject.
Device for cutting tubing , comprising: a frame having an entry window and an exit window for defining a pathway of the longitudinal axis of the tubing through the device ; a cutting element arranged on the frame , wherein the cutting element is arranged lateral and opposite to the pathway of the tubing; and wherein at least the portion of the frame is formed as a mobile portion and the cutting element is arranged on or opposite to the mobile portion to enable the cutting element to be pressed into the pathway of the longitudinal axis of the tubing , wherein the frame is formed closed loop-like, and has a flat bottom , a first arcuate shaped side for entry window , a second arcuate shaped side for the exit window , and an inclining top surface provided with the mobile portion , wherein an end of the mobile portion touches the second arcuate shaped side , and the mobile portion when being pushed downwards is moved along an inside of the second arcuate shaped side to perform a cutting action of the cutting element , and. wherein the frame further comprises protective walls for covering the cutting element . a frame having an entry window and an exit window for defining a pathway of the longitudinal axis of the tubing through the device ; a cutting element arranged on the frame , wherein the cutting element is arranged lateral and opposite to the pathway of the tubing; and wherein at least the portion of the frame is formed as a mobile portion and the cutting element is arranged on or opposite to the mobile portion to enable the cutting element to be pressed into the pathway of the longitudinal axis of the tubing , wherein the frame is formed closed loop-like, and has a flat bottom , a first arcuate shaped side for entry window , a second arcuate shaped side for the exit window , and an inclining top surface provided with the mobile portion , wherein an end of the mobile portion touches the second arcuate shaped side , and the mobile portion when being pushed downwards is moved along an inside of the second arcuate shaped side to perform a cutting action of the cutting element , and. wherein the frame further comprises protective walls for covering the cutting element .
A multiblock copolymer of Formula I : wherein: R 1a is H or an optionally substituted aliphatic group; R 1b is H or an optionally substituted aliphatic group; R 2 is H, an optionally substituted aliphatic group or an optionally substituted CO-(C1-C6)aliphatic group; each R y is independently a D-amino acid side chain; each R z is independently a L-amino acid side chain; x is 125-350; y is 5-35; z is 5-35. R 1a is H or an optionally substituted aliphatic group; R 1b is H or an optionally substituted aliphatic group; R 2 is H, an optionally substituted aliphatic group or an optionally substituted CO-(C1-C6)aliphatic group; each R y is independently a D-amino acid side chain; each R z is independently a L-amino acid side chain; x is 125-350; y is 5-35; z is 5-35.
A method of configuring a first computing device to provide a secondary authentication password for a password-protected web service, the method comprising: capturing, using an image capture device communicatively coupled to a first computing device, an encoded graphical image presented by a display of a second computing device, wherein the encoded graphical image comprises at least one indication of a uniform resource locator, URL, wherein the URL indicates a location where a secure authentication key can be accessed; accessing the secure authentication key from the location indicated by the URL; storing the secure authentication key on the first computing device; generating the secondary authentication password using the stored secure authentication key; and using the secondary authentication password to acquire access to a password-protected web service. capturing, using an image capture device communicatively coupled to a first computing device, an encoded graphical image presented by a display of a second computing device, wherein the encoded graphical image comprises at least one indication of a uniform resource locator, URL, wherein the URL indicates a location where a secure authentication key can be accessed; accessing the secure authentication key from the location indicated by the URL; storing the secure authentication key on the first computing device; generating the secondary authentication password using the stored secure authentication key; and using the secondary authentication password to acquire access to a password-protected web service.
Method for operating a vehicle having, as a drive apparatus, at least one electrical machine which is mechanically connected to drive wheels of the vehicle and is assigned at least one electrical storage unit which supplies the electrical machine with electrical energy, the electrical storage unit being charged by means of an electricity charging station as external energy source in the stationary state of the vehicle , characterized in that at least one checking device - connected to a specially prepared control unit - of the vehicle with sensors for monitoring the current flow during the charging process and the stationary state of the vehicle is activated during charging, the stationary state meaning that the vehicle does not roll away from the electricity charging station, and in that only upon detection of a fault state on the basis of a deviation of the state of the sensors from a target state of the sensors by means of the checking device , at least one safety device of the vehicle designed as braking device , charging process interruption device , information device , documentation device and/or restriction device for driving functions of the vehicle is activated, and in that upon detection of a fault state during the monitoring of the charging process, at least the charging process interruption device is activated as a safety device for interrupting the charging process.
Rail vehicle , comprising: - a rail vehicle outer wall having a door opening ; - a sliding door , which is set back relative to the rail vehicle outer wall towards an inner region of the rail vehicle and which, in the closed state, covers the door opening ; - a door frame on an edge region of the door opening ; - and wherein a gap sealed with a sealing element is formed between the sliding door , in the closed state, and the door frame ; characterized by - an aerodynamic door panel , which is oriented along the door frame , is fastened to the door frame , spatially distanced from the door frame and the sliding door , extends in the vertical extent of the sliding door and is arranged in front of the gap . - a rail vehicle outer wall having a door opening ; - a sliding door , which is set back relative to the rail vehicle outer wall towards an inner region of the rail vehicle and which, in the closed state, covers the door opening ; - a door frame on an edge region of the door opening ; - and wherein a gap sealed with a sealing element is formed between the sliding door , in the closed state, and the door frame ; characterized by - an aerodynamic door panel , which is oriented along the door frame , is fastened to the door frame , spatially distanced from the door frame and the sliding door , extends in the vertical extent of the sliding door and is arranged in front of the gap .
A filtration assembly for halting and retaining nanoparticles in suspension in an aerosol passing through the filtration assembly, the filtration assembly comprising an annular support which comprises an annular step having an apex on which a filter membrane rests, and a cover covering the annular support to hold a periphery of the membrane between the cover and the annular support, characterized in that the cover comprises a ring that can be slipped around the step to sandwich the periphery of the membrane between the ring and the annular support, the ring being extended by a skirt which projects out from the ring to cover an external peripheral wall of the annular support and to have an end face which extends in continuity with a bearing face of the annular support, the skirt ending in means for clip fastening onto the annular support .
A conveying device for conveying a viscous material from a container, - in which a follower plate , which can be inserted into the container , and a pump are provided, by means of which pump the viscous material can be conveyed through the follower plate , - in which a measuring chamber (31; 85) is provided for receiving a measuring sample of the viscous material , - in which the measuring chamber (31; 85) is provided with a closable material inlet opening (31.1; 85.1), - in which a closable disposal line is provided, which leads away from the measuring chamber (31; 85), - in which a closable material return line is provided, which leads from the measuring chamber (31; 85) into the container via the follower plate , - in which a controller is provided, which is formed and can be operated in such a way that -- in the case of several measuring samples , it determines the compressibility thereof in each case, and -- it releases the disposal line or the material return line for the measuring sample located in the measuring chamber (31; 85) as a function of the determined compressibility. - in which a follower plate , which can be inserted into the container , and a pump are provided, by means of which pump the viscous material can be conveyed through the follower plate , - in which a measuring chamber (31; 85) is provided for receiving a measuring sample of the viscous material , - in which the measuring chamber (31; 85) is provided with a closable material inlet opening (31.1; 85.1), - in which a closable disposal line is provided, which leads away from the measuring chamber (31; 85), - in which a closable material return line is provided, which leads from the measuring chamber (31; 85) into the container via the follower plate , - in which a controller is provided, which is formed and can be operated in such a way that -- in the case of several measuring samples , it determines the compressibility thereof in each case, and -- it releases the disposal line or the material return line for the measuring sample located in the measuring chamber (31; 85) as a function of the determined compressibility. -- in the case of several measuring samples , it determines the compressibility thereof in each case, and -- it releases the disposal line or the material return line for the measuring sample located in the measuring chamber (31; 85) as a function of the determined compressibility.
- A method of manufacturing an electronic module comprising in combination at least the following steps • Using a substrate comprising on at least one side one or more electrically conductive tracks , at least one conductive pad and at least one connection stud , • Connecting an integrated circuit to at least one connection stud , • Arranging one or more electrically conductive elements , characterised in that the method comprises the step of, • Connecting said electrically conductive element(s) to said at least one conductive pad of the substrate using an electrically conductive adhesive , wherein the integrated circuit is on the same side as the electrically conductive element (s) with respect to the substrate ; the electrically conductive track(s) , the at least one conductive pad and the at least one connection stud are on the same side as the electrically conductive element(s) with respect to the substrate . • Using a substrate comprising on at least one side one or more electrically conductive tracks , at least one conductive pad and at least one connection stud , • Connecting an integrated circuit to at least one connection stud , • Arranging one or more electrically conductive elements , characterised in that the method comprises the step of, • Connecting said electrically conductive element(s) to said at least one conductive pad of the substrate using an electrically conductive adhesive , wherein the integrated circuit is on the same side as the electrically conductive element (s) with respect to the substrate ; the electrically conductive track(s) , the at least one conductive pad and the at least one connection stud are on the same side as the electrically conductive element(s) with respect to the substrate .
An internal combustion engine having an oil circulating structure for dropping oil onto an oil pan , the oil used to lubricate a valve operating member provided with a cylinder head , and drawing the oil accumulated in the oil pan up to the cylinder head again, comprising: an oil dropping hole , into which the oil used to lubricate the valve operating member flows, is provided each on at least two corners of a square bottom face of the cylinder head , and an oil channel communicating with a bottom end of the oil dropping hole to guide the oil flowed into the oil channel to a driving gear , which transmits a driving force of the internal combustion engine , wherein the oil dropping hole is provided at two of the corners which are mutually diagonal.
An optical mount , comprising: a mount material shaped in a closed geometry with an outer surface having sized for matching internal dimensions of an outer housing, and an inner surface comprising a plurality of spaced apart inward extending contacting features with each providing contact points that collectively define an inner opening that is sized for securing an optical device within, the optical device including a crystal and of prismatic shape and planar sides intersecting at the corners thereof, and a feature gap or a recessed portion between the inward extending contacting features; edge holders adapted for receiving the corners of the optical device comprising a protrusion pair or inner notches; the outer surface including at least one outer notch between the inward extending contacting features; wherein the edge holders and the outer notch are for each acting as hinge points opening or pinching depending on a direction of force for the optical mount responding with flexure when there is a dimensional change in the crystal, in the mount material, or in the housing. a mount material shaped in a closed geometry with an outer surface having sized for matching internal dimensions of an outer housing, and an inner surface comprising a plurality of spaced apart inward extending contacting features with each providing contact points that collectively define an inner opening that is sized for securing an optical device within, the optical device including a crystal and of prismatic shape and planar sides intersecting at the corners thereof, and a feature gap or a recessed portion between the inward extending contacting features; edge holders adapted for receiving the corners of the optical device comprising a protrusion pair or inner notches; the outer surface including at least one outer notch between the inward extending contacting features; wherein the edge holders and the outer notch are for each acting as hinge points opening or pinching depending on a direction of force for the optical mount responding with flexure when there is a dimensional change in the crystal, in the mount material, or in the housing.
Absorber device for a vehicle , in particular for absorbing kinetic energy in a collision of the vehicle , comprising - at least two absorber elements being configured so as to be mountable on a load introduction section of a vehicle frame of the vehicle and defining an absorption direction , - a holding device , and - a collision bar with two bar ends , configured to directly absorb collision forces, - wherein the collision bar , in a designated operating position, is positioned by means of the holding device in a coupling plane on the absorber elements such that collision forces can be conducted from the collision bar via the bar ends into the absorber elements , and - wherein the collision bar can be arranged by using the holding device in a designated stowed position outside the coupling plane such that the collision bar is displaced relative to the operating position at least partially perpendicularly to the absorption direction , and that the collision bar in the stowed position, relative to its operating position, does not protrude, by maximum 5 cm, by maximum 10 cm or by no more than 1% of a total length of the vehicle opposite the absorption direction . - at least two absorber elements being configured so as to be mountable on a load introduction section of a vehicle frame of the vehicle and defining an absorption direction , - a holding device , and - a collision bar with two bar ends , configured to directly absorb collision forces, - wherein the collision bar , in a designated operating position, is positioned by means of the holding device in a coupling plane on the absorber elements such that collision forces can be conducted from the collision bar via the bar ends into the absorber elements , and - wherein the collision bar can be arranged by using the holding device in a designated stowed position outside the coupling plane such that the collision bar is displaced relative to the operating position at least partially perpendicularly to the absorption direction , and that the collision bar in the stowed position, relative to its operating position, does not protrude, by maximum 5 cm, by maximum 10 cm or by no more than 1% of a total length of the vehicle opposite the absorption direction .