mhurhangee/patent-ind-claim-en huggingface dataset:
Use of an expression vector containing at least one nucleotide sequence targeting by RNA interference the DPH2 gene transcript of a human cell for inducing resistance to diphtheria toxin in a human cell, wherein the expression vector is used in vivo in a rodent xenografted with a human cell, wherein the transcript of the expression vector is permanently transduced in the human cell, whereby the permanently transduced human cell survives upon diphtheria toxin treatment, wherein the expression vector contains at least one additional nucleotide sequence, whereby the permanently transduced human cell surviving upon diphtheria toxin treatment contains the at least one additional nucleotide sequence, and wherein the at least one additional nucleotide sequence is selected from: i) nucleotide sequences encoding a fluorescent or bioluminescent protein, ii) nucleotide sequences encoding an enzymatic protein marker, iii) nucleotide sequences promoting loss-of-function of an endogenous gene of the permanently transduced human cell, and iv) nucleotide sequences promoting gain-of-function of an endogenous or exogenous gene in the permanently transduced human cell.
A rack for mounting on a bicycle, comprising: a platform , said platform having a top surface , a recess , and a structure for removably mounting said platform with respect to the frame of a bicycle; and left and right skirts mounted on said platform so that they can be carried on said platform in a stored position; characterized in that the rack further comprises a post comprising a T-bar having a shank and a cross bar , the shank being pivotally mounted in the recess so that the T-bar is movable between an extended operative position in which at least a part of the T-bar extends upwardly through the recess and above the top surface of the platform and a retracted position wherein the T-bar lies completely in the recess ; further comprising a pocket in which the shank is mounted and a pivot pin engaged through the pocket and the shank ; wherein said skirts are positionable in a deployed position to inhibit grocery bags engaged on said post from engaging the rear wheel of the bicycle. a platform , said platform having a top surface , a recess , and a structure for removably mounting said platform with respect to the frame of a bicycle; and left and right skirts mounted on said platform so that they can be carried on said platform in a stored position; characterized in that the rack further comprises a post comprising a T-bar having a shank and a cross bar , the shank being pivotally mounted in the recess so that the T-bar is movable between an extended operative position in which at least a part of the T-bar extends upwardly through the recess and above the top surface of the platform and a retracted position wherein the T-bar lies completely in the recess ; further comprising a pocket in which the shank is mounted and a pivot pin engaged through the pocket and the shank ; wherein said skirts are positionable in a deployed position to inhibit grocery bags engaged on said post from engaging the rear wheel of the bicycle.
A method, implemented by a system of computing devices, the method comprising: receiving, from a first computing device associated with a first user , an instruction to generate an invitation to communicate via a direct messaging instance managed by a communication platform , wherein the invitation comprises an access code associated with enabling direct messaging communications with the first user , the access code comprising a unique identifier associated with generating the direct messaging instance with the first user ; generating the invitation based at least in part on the instruction, wherein the invitation comprises the access code ; sending the invitation to a second computing device associated with a second user , wherein the second user is associated with a second organization that is different from a first organization associated with the first user ; receiving an indication that the access code has been selected by the second user ; based at least in part on the received indication and the access code , generating the direct messaging instance between the first user and the second user , wherein the direct messaging instance enables messages to be transmitted between the first computing device and the second computing device ; and providing an interface including the direct messaging instance to the first computing device and the second computing device . receiving, from a first computing device associated with a first user , an instruction to generate an invitation to communicate via a direct messaging instance managed by a communication platform , wherein the invitation comprises an access code associated with enabling direct messaging communications with the first user , the access code comprising a unique identifier associated with generating the direct messaging instance with the first user ; generating the invitation based at least in part on the instruction, wherein the invitation comprises the access code ; sending the invitation to a second computing device associated with a second user , wherein the second user is associated with a second organization that is different from a first organization associated with the first user ; receiving an indication that the access code has been selected by the second user ; based at least in part on the received indication and the access code , generating the direct messaging instance between the first user and the second user , wherein the direct messaging instance enables messages to be transmitted between the first computing device and the second computing device ; and providing an interface including the direct messaging instance to the first computing device and the second computing device .
A method of printing a color surface of an object by printing dots of curable ink in several superposed layers, the method comprising the steps of: a) defining a micro-texture , the micro-texture being a repetitive pattern of elevated parts; b) establishing a gloss function that indicates a gloss value (G) of a surface having said micro-texture, as a function of a height difference (H) between a maximum height of the elevated parts and a minimum height of the depressed parts of the micro-texture; c) assigning a target gloss value (Gt) to at least a part of a surface area of the object ; d) determining, on the basis of the gloss function , a required local height difference (H) corresponding to the target gloss value (Gt); and e) forming, on said part of the surface area of the object , the micro-texture with a height profile scaled to the required local height difference (H), characterized in that the elevated parts take the form of pillars that have a uniform height and a uniform cross-sectional shape over their entire height, and the depressed parts take the form of gaps between the pillars. a) defining a micro-texture , the micro-texture being a repetitive pattern of elevated parts; b) establishing a gloss function that indicates a gloss value (G) of a surface having said micro-texture, as a function of a height difference (H) between a maximum height of the elevated parts and a minimum height of the depressed parts of the micro-texture; c) assigning a target gloss value (Gt) to at least a part of a surface area of the object ; d) determining, on the basis of the gloss function , a required local height difference (H) corresponding to the target gloss value (Gt); and e) forming, on said part of the surface area of the object , the micro-texture with a height profile scaled to the required local height difference (H), characterized in that the elevated parts take the form of pillars that have a uniform height and a uniform cross-sectional shape over their entire height, and the depressed parts take the form of gaps between the pillars.
A compound having a structure according to Formula III: wherein: X is fluorine; R is fluorine or chlorine; each R a is independently selected from: H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, OH, OC 1 - 3 alkyl, CN, fluorine, chlorine, or a phenyl optionally substituted with 1-3 groups selected from fluorine, chlorine, C 1 -C 3 alkyl, CN, OC 1 -C 3 alkyl, and OH; each R b is independently selected from: H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, OH, OC 1 - 3 alkyl, CN, fluorine, chlorine, or a phenyl optionally substituted with 1-3 groups selected from fluorine, chlorine, C 1 -C 3 alkyl, CN, OC 1 -C 3 alkyl, and OH; and U and V are each independently selected from CR a or N; or, a compound selected from the group consisting of: or a pharmaceutically acceptable salt of said compound of Formula III or a pharmaceutically acceptable salt of D-105, D-106, D-108, D-109 or D110. X is fluorine; R is fluorine or chlorine; each R a is independently selected from: H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, OH, OC 1 - 3 alkyl, CN, fluorine, chlorine, or a phenyl optionally substituted with 1-3 groups selected from fluorine, chlorine, C 1 -C 3 alkyl, CN, OC 1 -C 3 alkyl, and OH; each R b is independently selected from: H, C 1 -C 3 alkyl, C 1 -C 3 fluoroalkyl, OH, OC 1 - 3 alkyl, CN, fluorine, chlorine, or a phenyl optionally substituted with 1-3 groups selected from fluorine, chlorine, C 1 -C 3 alkyl, CN, OC 1 -C 3 alkyl, and OH; and U and V are each independently selected from CR a or N; or, a compound selected from the group consisting of: or a pharmaceutically acceptable salt of said compound of Formula III or a pharmaceutically acceptable salt of D-105, D-106, D-108, D-109 or D110.
A vane for use with a stator assembly, the vane comprising: an upper mounting portion ; a lower mounting portion ; an airfoil body extending between the upper mounting portion and the lower mounting portion; a first integrally formed metal fillet located between the upper mounting portion and the airfoil body, and a second integrally formed metal fillet located between the lower mounting portion and the airfoil body, wherein the first integrally formed metal fillet extends completely around a periphery of the airfoil and the second integrally formed metal fillet extends completely around a periphery of the airfoil, characterized in that ; the first integrally formed metal fillet defining a first mounting surface located between the upper mounting portion and the first integrally formed metal fillet, the first mounting surface extending laterally away from the upper mounting portion, and the second integrally formed metal fillet defining a second mounting surface located between the lower mounting portion and second integrally formed metal fillet, the second mounting surface extending laterally away from the lower mounting portion. an upper mounting portion ; a lower mounting portion ; an airfoil body extending between the upper mounting portion and the lower mounting portion; a first integrally formed metal fillet located between the upper mounting portion and the airfoil body, and a second integrally formed metal fillet located between the lower mounting portion and the airfoil body, wherein the first integrally formed metal fillet extends completely around a periphery of the airfoil and the second integrally formed metal fillet extends completely around a periphery of the airfoil, characterized in that ; the first integrally formed metal fillet defining a first mounting surface located between the upper mounting portion and the first integrally formed metal fillet, the first mounting surface extending laterally away from the upper mounting portion, and the second integrally formed metal fillet defining a second mounting surface located between the lower mounting portion and second integrally formed metal fillet, the second mounting surface extending laterally away from the lower mounting portion.
Method for controlling a real warehouse which comprises conveyor installations, automated machines and persons, for which purpose the real warehouse, including conveyor installations, automated machines and persons, is virtualised in a central computer, for which purpose a virtual model of the warehouse, including the real conveyor installation, the automated machines and the persons with their dimensions and movement parameters, including the actuator properties, is stored, images of the objects to be conveyed, automated machines and persons in the conveyor installation are captured by means of sensors at predefined short time intervals, the objects to be conveyed, automated machines and persons are identified from the captured images in the central computer by means of image recognition and the positions thereof in the real warehouse at the time of image capture are determined, and the virtual model is continuously updated with the identification and position determination of the objects in the central computer such that a virtualised real-time model is generated therefrom and the real conveyor installation and/or the automated machines are centrally controlled with the aid of the virtualised real-time model, wherein material flow control commands are generated for the real actuators for controlling the conveying movement of the respective conveyor installations and/or automated machines in order to avoid endangering the persons. for which purpose the real warehouse, including conveyor installations, automated machines and persons, is virtualised in a central computer, for which purpose a virtual model of the warehouse, including the real conveyor installation, the automated machines and the persons with their dimensions and movement parameters, including the actuator properties, is stored, images of the objects to be conveyed, automated machines and persons in the conveyor installation are captured by means of sensors at predefined short time intervals, the objects to be conveyed, automated machines and persons are identified from the captured images in the central computer by means of image recognition and the positions thereof in the real warehouse at the time of image capture are determined, and the virtual model is continuously updated with the identification and position determination of the objects in the central computer such that a virtualised real-time model is generated therefrom and the real conveyor installation and/or the automated machines are centrally controlled with the aid of the virtualised real-time model, wherein material flow control commands are generated for the real actuators for controlling the conveying movement of the respective conveyor installations and/or automated machines in order to avoid endangering the persons.
A near field communication, NFC, reader, comprising: an antenna front-end that includes a low pass filter , a matching circuit and an antenna coil ; and a NFC controller , wherein the NFC controller includes an oscillator coupled to the antenna front-end and the NFC controller is configured to detect a presence of an object in proximity of the antenna front-end using one or more changes in an output of the oscillator , wherein the antenna front-end has an inductance, which is in particular representable by an inductor , and a capacitance, which is in particular representable by capacitors , and forms a tank circuit that is connected to the oscillator , characterized in that the NFC controller includes a control that is configured to cause the oscillator to start resonating using a startup pulse, and to determine a width of the startup pulse based on the inductance of the antenna front-end at a time of starting the oscillator , wherein the oscillator is configured to be tuned to oscillate at the boundary of its operational stability by selecting the value of the impedance formed by the inductance and the capacitance of the antenna front-end based on the width of the startup pulse when the object is not in proximity of the antenna front-end ; and wherein the NFC controller is configured to determine that an object is in the proximity of the antenna front-end when the oscillator enters a non-resonating mode and stops to resonate due to changes in the inductance of the antenna front-end . an antenna front-end that includes a low pass filter , a matching circuit and an antenna coil ; and a NFC controller ,
A tongue for connection of a building panel, said tongue being of an elongated shape and being made of moulded plastic, wherein the tongue comprises at least two protrusions at a first long edge (L1) of the tongue, the protrusions being bendable in a plane parallel to an upper surface of the tongue and extending essentially in the parallel plane, and the tongue having a second long edge (L2), which is essentially straight over substantially the whole length of the tongue, wherein the tongue comprises a gluing part configured to be glued into a groove at an edge of the building panel, said gluing part being a gluing strip extending in a longitudinal direction of the tongue, and said gluing strip being attached to outer ends of some of the protrusions .
A method for transmitting a User Equipment, UE, specific reference signal sequence at a base station in a wireless communication system, the method comprising: generating the UE specific reference signal sequence based on a pseudo-random sequence ( c ( n )); and transmitting the UE specific reference signal sequence to a UE, wherein the pseudo-random sequence is defined by following equation 1, c n = x 1 n + N C + x 2 n + N C mod 2 x 1 n + 31 = x 1 n + 3 + x 1 n mod 2 x 2 n + 31 = x 2 n + 3 + x 2 n + 2 + x 2 n + 1 + x 2 n mod 2 wherein N C = 1600 and a first m-sequence ( x 1 ( n )) is initialized with x 1 = 1 ,x 1 ( n ) = 0, n = 1,2,...,30, wherein a second m-sequence ( x 2 ( n )) is initialized with k + ⌊ n s / 2 ⌋ + 1 ⋅ 2 n ID + 1 ⋅ 2 16 , wherein n s is a slot number within a radio frame, k includes a scrambling identity of the UE specific reference signal sequence (N DRS ) and a parameter according to a multiplexing scheme of the UE specific reference signal sequence n RNTI , wherein nRNTI is 0 if the multiplexing scheme is Frequency Division Multiplexing, FDM, for a single-cell multi-user multi input multi output, MIMO, mode transmission, and n ID is an identity configured based on a MIMO transmission mode, and wherein the scrambling identity (N DRS ) is transmitted to the UE through a Physical Downlink Control Channel, PDCCH and information on the scrambling identity (N DRS ) is included in a Downlink Control Information, DCI, format 2B associated with a Physical Downlink Shared Channel, PDSCH. generating the UE specific reference signal sequence based on a pseudo-random sequence ( c ( n )); and transmitting the UE specific reference signal sequence to a UE, wherein the pseudo-random sequence is defined by following equation 1, c n = x 1 n + N C + x 2 n + N C mod 2 x 1 n + 31 = x 1 n + 3 + x 1 n mod 2 x 2 n + 31 = x 2 n + 3 + x 2 n + 2 + x 2 n + 1 + x 2 n mod 2 wherein N C = 1600 and a first m-sequence ( x 1 ( n )) is initialized with x 1 = 1 ,x 1 ( n ) = 0, n = 1,2,...,30, wherein a second m-sequence ( x 2 ( n )) is initialized with k + ⌊ n s / 2 ⌋ + 1 ⋅ 2 n ID + 1 ⋅ 2 16 , wherein n s is a slot number within a radio frame, k includes a scrambling identity of the UE specific reference signal sequence (N DRS ) and a parameter according to a multiplexing scheme of the UE specific reference signal sequence n RNTI , wherein nRNTI is 0 if the multiplexing scheme is Frequency Division Multiplexing, FDM, for a single-cell multi-user multi input multi output, MIMO, mode transmission, and n ID is an identity configured based on a MIMO transmission mode, and wherein the scrambling identity (N DRS ) is transmitted to the UE through a Physical Downlink Control Channel, PDCCH and information on the scrambling identity (N DRS ) is included in a Downlink Control Information, DCI, format 2B associated with a Physical Downlink Shared Channel, PDSCH.
An anticancer agent for use as a medicament for reducing recurrence of tumor growth in a mammalian tissue in a mammal at and around a location in said mammal of an excised tumor: wherein said agent is selected from the group consisting of Bleomycin, cisplatin, a protein, an antibody, RNAi, an antisense nucleic acid, an expressible gene encoding a therapeutically active polypeptide, a chemokine, and a cytokine; wherein said agent is for administration to said tissue by means of intravenous injection or injected directly at and around said tissue either prior to or simultaneously with administration of an electroporative electric pulse to said tissue, thereby delivering said agent into cells of said tissue resulting in a reduction or elimination of tumor cell growth in said tissue. wherein said agent is selected from the group consisting of Bleomycin, cisplatin, a protein, an antibody, RNAi, an antisense nucleic acid, an expressible gene encoding a therapeutically active polypeptide, a chemokine, and a cytokine; wherein said agent is for administration to said tissue by means of intravenous injection or injected directly at and around said tissue either prior to or simultaneously with administration of an electroporative electric pulse to said tissue, thereby delivering said agent into cells of said tissue resulting in a reduction or elimination of tumor cell growth in said tissue.
An electrically-switchable flexible ophthalmic lens for conforming to the eye of a user, the lens comprising: a liquid crystal cell for changing at least one optical characteristic of the ophthalmic lens, and having a cell gap thickness (G, G") between a first inner surface and a second inner surface with liquid crystal therebetween, the flexible liquid crystal cell having a chord radius, w, and comprising: a plurality of support members, wherein each support member is arranged to maintain the cell gap thickness by providing support at one or more support locations within the cell, characterised in that the support members are arranged such that the support locations form two rings concentric with a centre of the liquid crystal cell, the first ring located a chord measurement of 0.26-0.34w from the centre of the liquid crystal cell and the second ring located a chord measurement of 0.52-0.70w from the centre of the liquid crystal cell; and the support locations form two, and only two, rings. a plurality of support members, wherein each support member is arranged to maintain the cell gap thickness by providing support at one or more support locations within the cell, characterised in that the support members are arranged such that the support locations form two rings concentric with a centre of the liquid crystal cell, the first ring located a chord measurement of 0.26-0.34w from the centre of the liquid crystal cell and the second ring located a chord measurement of 0.52-0.70w from the centre of the liquid crystal cell; and the support locations form two, and only two, rings.
A device for moving at least two modules (14-1, 14-2, 14-3) of a swimming pool shelter of the type with nesting modules, comprising at least right and left lower spacers and right and left upper spacers, said moving device comprising ground-based rolling wheels R secured to said lower spacers and carriages (18-1, 18-2, 18-3) which each have a casing and two flanges (20-1, 20-2), each carriage (18-1, 18-2, 18-3) incorporating moving means (24D and 24G) which each comprise an upstream pinion , a downstream pinion and a link (28-1, 28-2, 28-3) tensioned between said two pinions, and guide and fastening cleats attached to said links and to said carriages, allowing the modules to be mutually guided and simultaneously moved.