mhurhangee/patent-ind-claim-en huggingface dataset:
A compound having the structure of Formula (I): wherein: X 1 is O, S, N(R 3 ), or C(NO 2 )(R 4 ); X 2 is -N(R 5 )- or-C(R 5 ) 2 -; X 3 is -N(R 5 )- or -C(R 5 ) 2 -; X 4 is -C(O)- or -CH 2 -; Y 1 is O; Y 2 is N or C(R 9 ); Y 3 is O or N(R 10 ); Z is N or C(R 19 ); R 1 is or R 2 is R 3 is -OR 14 , -CN, -NO 2 , or -S(=O) 2 R 15 ; R 4 is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 heteroalkyl; each R 5 is independently selected from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 heteroalkyl; R 6 is -OH, -C 1 -C 6 alkyl-OH, or-NH(R 16 ); each R 7 is independently selected from C 1 -C 6 alkyl, -C 1 -C 6 alkyl-CO 2 R 18 , C 1 -C 6 haloalkyl, and C 1 -C 6 heteroalkyl; or R 6 and R 7 are combined to form a 5-or 6-membered heteroaryl ring; R 9 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 heteroalkyl; R 10 is -OH or -O-C 1 -C 6 alkyl; R 11 is C 1 -C 6 alkyl; R 12 is C 1 -C 6 alkyl; each R 13 is independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, and C 1 -C 6 heteroalkyl; R 14 is hydrogen or C 1 -C 6 alkyl; R 15 is C 1 -C 6 alkyl; R 16 is hydrogen, C 1 -C 6 alkyl or -C(O)-C 1 -C 6 alkyl; R 17 is hydrogen or C 1 -C 6 alkyl; R 18 is hydrogen or C 1 -C 6 alkyl; R 19 is hydrogen, halogen, -CN, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 heteroalkyl; n is 0, 1, 2, or 3; p is 0, 1, 2, 3, or 4; q is 0, 1, or 2; s is 1, 2, or 3; and t is 1, 2, or 3; or a pharmaceutically acceptable salt or solvate thereof. X 1 is O, S, N(R 3 ), or C(NO 2 )(R 4 ); X 2 is -N(R 5 )- or-C(R 5 ) 2 -; X 3 is -N(R 5 )- or -C(R 5 ) 2 -; X 4 is -C(O)- or -CH 2 -; Y 1 is O; Y 2 is N or C(R 9 ); Y 3 is O or N(R 10 ); Z is N or C(R 19 ); R 1 is or R 2 is R 3 is -OR 14 , -CN, -NO 2 , or -S(=O) 2 R 15 ; R 4 is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 heteroalkyl; each R 5 is independently selected from hydrogen, C 1 -C 6 alkyl, and C 1 -C 6 heteroalkyl; R 6 is -OH, -C 1 -C 6 alkyl-OH, or-NH(R 16 ); each R 7 is independently selected from C 1 -C 6 alkyl, -C 1 -C 6 alkyl-CO 2 R 18 , C 1 -C 6 haloalkyl, and C 1 -C 6 heteroalkyl; or R 6 and R 7 are combined to form a 5-or 6-membered heteroaryl ring; R 9 is hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 heteroalkyl; R 10 is -OH or -O-C 1 -C 6 alkyl; R 11 is C 1 -C 6 alkyl; R 12 is C 1 -C 6 alkyl; each R 13 is independently selected from halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, and C 1 -C 6 heteroalkyl; R 14 is hydrogen or C 1 -C 6 alkyl; R 15 is C 1 -C 6 alkyl; R 16 is hydrogen, C 1 -C 6 alkyl or -C(O)-C 1 -C 6 alkyl; R 17 is hydrogen or C 1 -C 6 alkyl; R 18 is hydrogen or C 1 -C 6 alkyl; R 19 is hydrogen, halogen, -CN, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 1 -C 6 heteroalkyl; n is 0, 1, 2, or 3; p is 0, 1, 2, 3, or 4; q is 0, 1, or 2; s is 1, 2, or 3; and t is 1, 2, or 3; or a pharmaceutically acceptable salt or solvate thereof.
A pharmaceutical composition comprising a Vaccinium bracteatum Thunb. leaf extract as an effective ingredient for use in the prevention or treatment of stress-related anxiety and depression; wherein the Vaccinium bracteatum Thunb. leaf extract is obtained using one selected from water, methanol, and a mixture thereof as an extraction solvent.
An atomizing device comprising: a heating member ; and a temperature control switch ; wherein the temperature control switch is positioned adjacent to the heating member, or the heating member is sleeved on the temperature control switch, the heating member is coupled to the temperature control switch in series, and the heating member and the temperature control switch are electrically coupled to a power supply device; characterized in that : the temperature control switch is provided for directly controlling a temperature of the heating member; and when a temperature ts of the temperature control switch is less than an operating temperature TM of the temperature control switch, the temperature control switch is switched on, when the temperature ts is greater than the operating temperature TM, the temperature control switch is switched off. a heating member ; and a temperature control switch ; wherein the temperature control switch is positioned adjacent to the heating member, or the heating member is sleeved on the temperature control switch, the heating member is coupled to the temperature control switch in series, and the heating member and the temperature control switch are electrically coupled to a power supply device; characterized in that : the temperature control switch is provided for directly controlling a temperature of the heating member; and when a temperature ts of the temperature control switch is less than an operating temperature TM of the temperature control switch, the temperature control switch is switched on, when the temperature ts is greater than the operating temperature TM, the temperature control switch is switched off. the temperature control switch is provided for directly controlling a temperature of the heating member; and when a temperature ts of the temperature control switch is less than an operating temperature TM of the temperature control switch, the temperature control switch is switched on, when the temperature ts is greater than the operating temperature TM, the temperature control switch is switched off.
A substrate inspection apparatus without a reference mirror, comprising: a light source configured to radiate laser light onto a region of a coated film that is spread on a substrate; a light detector configured to obtain optical interference data on an interference between reference light, that is generated by the laser light being reflected from a surface of the region of the coated film, and measurement light, that is generated by the laser light penetrating the region of the coated film and being scattered; a movement part configured to move the light source ; and a processor configured to: derive a reflectivity of the surface from an intensity of the reference light; determine whether the reflectivity is less than a predetermined reflectivity; upon the determination that the reflectivity is not less than the predetermined reflectivity, derive a thickness of the coated film corresponding to the region based on the optical interference data; and upon the determination that the reflectivity is less than the predetermined reflectivity, control the movement part to move the light source so as to radiate laser light onto another region adjacent to the region of the coated film on the substrate. a light source configured to radiate laser light onto a region of a coated film that is spread on a substrate; a light detector configured to obtain optical interference data on an interference between reference light, that is generated by the laser light being reflected from a surface of the region of the coated film, and measurement light, that is generated by the laser light penetrating the region of the coated film and being scattered; a movement part configured to move the light source ; and a processor configured to: derive a reflectivity of the surface from an intensity of the reference light; determine whether the reflectivity is less than a predetermined reflectivity; upon the determination that the reflectivity is not less than the predetermined reflectivity, derive a thickness of the coated film corresponding to the region based on the optical interference data; and upon the determination that the reflectivity is less than the predetermined reflectivity, control the movement part to move the light source so as to radiate laser light onto another region adjacent to the region of the coated film on the substrate. derive a reflectivity of the surface from an intensity of the reference light; determine whether the reflectivity is less than a predetermined reflectivity; upon the determination that the reflectivity is not less than the predetermined reflectivity, derive a thickness of the coated film corresponding to the region based on the optical interference data; and upon the determination that the reflectivity is less than the predetermined reflectivity, control the movement part to move the light source so as to radiate laser light onto another region adjacent to the region of the coated film on the substrate.
A pharmaceutical combination or medicament for use in treating a human cancer patient, the combination or medicament comprising: (a) a therapeutical effective amount of recombinant poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA) selected from the group consisting of carcinoembryonic (CEA), mucin 1 cell surface associated (MUC-1), prostate specific antigen (PSA), human epidermal growth factor 2 (HER-2), and Brachyury; and (b) a subtherapeutically effective amount of an immune checkpoint antagonist that is a PD-1 antagonist or a CTLA-4 antagonist, wherein the pharmaceutical combination or medicament comprises a PD-1 antagonist and a CTLA-4 antagonist, and wherein each of said PD-1 antagonist and CTLA-4 antagonist is an antibody, an antisense RNA, or an siRNA. (a) a therapeutical effective amount of recombinant poxvirus encoding a polypeptide comprising at least one tumor-associated antigen (TAA) selected from the group consisting of carcinoembryonic (CEA), mucin 1 cell surface associated (MUC-1), prostate specific antigen (PSA), human epidermal growth factor 2 (HER-2), and Brachyury; and (b) a subtherapeutically effective amount of an immune checkpoint antagonist that is a PD-1 antagonist or a CTLA-4 antagonist, wherein the pharmaceutical combination or medicament comprises a PD-1 antagonist and a CTLA-4 antagonist, and wherein each of said PD-1 antagonist and CTLA-4 antagonist is an antibody, an antisense RNA, or an siRNA.
A diisocyanate composition for an optical lens, which has a pH of 5.0 to 5.8.
Brush-holder assembly for an electric motor of a piece of motor vehicle equipment comprising: - a plate intended to hold at least one connection brush against a commutator disposed on a rotor of the electric motor , the plate extending in a plane at right angles to said rotor , - at least one inductor intended to be connected to said connection brush , characterized in that the brush-holder assembly comprises at least one holding element for the at least one inductor configured to hold the inductor in a plane parallel to the plate , the holding element being removably fixed to the plate . - a plate intended to hold at least one connection brush against a commutator disposed on a rotor of the electric motor , the plate extending in a plane at right angles to said rotor , - at least one inductor intended to be connected to said connection brush ,
A method of producing an electrical through connection between a first surface and a second surface of a flexible substrate , comprising the steps of: a. in a first step, providing a cut on an area of the flexible substrate , wherein the cut extends from the first surface to the second surface and separates the area into at least a first part and a second part ; b. raising up at least one of the first part and the second part from a first plane of the first surface ; c. printing a first wet conductive layer on the first surface , wherein the first wet conductive layer is on and around the cut ; d. solidifying the first wet conductive layer into a first dried conductive layer ; e. raising up at least one of the first part and the second part from a second plane of the second surface ; f. printing a second wet conductive layer on the second surface , wherein the second wet conductive layer is on and around the cut ; and g. solidifying the second wet conductive layer into a second dried conductive layer , wherein the first dried conductive layer and the second dried conductive layer create the electrical through connection . a. in a first step, providing a cut on an area of the flexible substrate , wherein the cut extends from the first surface to the second surface and separates the area into at least a first part and a second part ; b. raising up at least one of the first part and the second part from a first plane of the first surface ; c. printing a first wet conductive layer on the first surface , wherein the first wet conductive layer is on and around the cut ; d. solidifying the first wet conductive layer into a first dried conductive layer ; e. raising up at least one of the first part and the second part from a second plane of the second surface ; f. printing a second wet conductive layer on the second surface , wherein the second wet conductive layer is on and around the cut ; and g. solidifying the second wet conductive layer into a second dried conductive layer , wherein the first dried conductive layer and the second dried conductive layer create the electrical through connection .
Packaging and application device , comprising: - a container containing a product (P) to be applied, - a screen through which the product contained in the container exits, the screen having dispensing orifices with different sections, with at least three orifices of which the section varies in a strictly decreasing manner with distance (d) from the centre of the screen, the ratio of the sections S min/ S max between that (S min ) of the smallest orifice and that (S max ) of the largest orifice varying from 1/5 to 1/1000. - a container containing a product (P) to be applied, - a screen through which the product contained in the container exits, the screen having dispensing orifices with different sections, with at least three orifices of which the section varies in a strictly decreasing manner with distance (d) from the centre of the screen, the ratio of the sections S min/ S max between that (S min ) of the smallest orifice and that (S max ) of the largest orifice varying from 1/5 to 1/1000.
A pacing lead comprising: an elongate body defining a lumen extending from a proximal portion to a distal portion configured to receive a guide wire; and a left-ventricular electrode coupled to the elongate body implantable from tissue adjacent to or within the triangle of Koch region of the right atrium through the right-atrial endocardium to deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal region, septal region, or basal-septal region of the left ventricular myocardium of a patient's heart. an elongate body defining a lumen extending from a proximal portion to a distal portion configured to receive a guide wire; and a left-ventricular electrode coupled to the elongate body implantable from tissue adjacent to or within the triangle of Koch region of the right atrium through the right-atrial endocardium to deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal region, septal region, or basal-septal region of the left ventricular myocardium of a patient's heart.
A neutron image detection method for collecting fluorescent light generated by a neutron incident at a designated position interval in one-dimensional geometry and determining an incident position of the neutron by detecting the collected fluorescent light, wherein the fluorescent light is detected by a photon counting method; wherein a pulse signal generated by an individual output photon is extracted; a count-value distribution is obtained in terms of incident position as variable, upon a single neutron incident, by counting the pulse signal output; and a neutron incident position is determined by calculating a median point on the basis of the obtained count-value distribution, characterised in that the pulse signal generated by an individual output photon is extracted on the basis of a clock signal generated with the same time interval as the time width of the pulse signal generated by a single photon.
An access node comprising a transceiver and a processor , the transceiver being configured to receive one or more uplink pilots associated with a user node via a radio link , wherein the processor is configured to: determine, based on the one or more uplink pilots, a physical location of the user node and whether the radio link is a line of sight radio link or a non-line of sight radio link ; and when the radio link is the line of sight radio link , the processor is configured to: determine a position based precoding vector based on the physical location of the user node , wherein selection of the precoding vector is based on knowledge of the absolute physical location of the user node , and the position based precoding is determined using narrowband beacons having few pilots as compared to wideband beacons used for channel based precoding; and generate a precoded downlink control signal based on the determined position based precoding vector, and wherein the transceiver is configured to transmit the precoded downlink control signal to the user node . determine, based on the one or more uplink pilots, a physical location of the user node and whether the radio link is a line of sight radio link or a non-line of sight radio link ; and when the radio link is the line of sight radio link , the processor is configured to: determine a position based precoding vector based on the physical location of the user node , wherein selection of the precoding vector is based on knowledge of the absolute physical location of the user node , and the position based precoding is determined using narrowband beacons having few pilots as compared to wideband beacons used for channel based precoding; and generate a precoded downlink control signal based on the determined position based precoding vector, and wherein the transceiver is configured to transmit the precoded downlink control signal to the user node . determine a position based precoding vector based on the physical location of the user node , wherein selection of the precoding vector is based on knowledge of the absolute physical location of the user node , and the position based precoding is determined using narrowband beacons having few pilots as compared to wideband beacons used for channel based precoding; and generate a precoded downlink control signal based on the determined position based precoding vector, and wherein the transceiver is configured to transmit the precoded downlink control signal to the user node .
A ring type wearable terminal comprising: a ring ; and a communication unit that is housed in the ring , wherein the communication unit is provided with a ring-shaped flexible substrate , wherein the flexible substrate is provided with a plurality of linear patterns that extend in a longitudinal direction, characterized by the flexible substrate being provided with bonding portions formed such that the bonding portions are bonded at a position in a longitudinal direction in accordance with the size of the ring , wherein each of the bonding portions are formed at a respective end portion of the plurality of linear patterns and wherein the plurality of linear patterns form a single loop antenna once the bonding portions are bonded. a ring ; and a communication unit that is housed in the ring , wherein the communication unit is provided with a ring-shaped flexible substrate , wherein the flexible substrate is provided with a plurality of linear patterns that extend in a longitudinal direction, characterized by the flexible substrate being provided with bonding portions formed such that the bonding portions are bonded at a position in a longitudinal direction in accordance with the size of the ring , wherein each of the bonding portions are formed at a respective end portion of the plurality of linear patterns and wherein the plurality of linear patterns form a single loop antenna once the bonding portions are bonded. wherein the communication unit is provided with a ring-shaped flexible substrate , wherein the flexible substrate is provided with a plurality of linear patterns that extend in a longitudinal direction, characterized by the flexible substrate being provided with bonding portions formed such that the bonding portions are bonded at a position in a longitudinal direction in accordance with the size of the ring , wherein each of the bonding portions are formed at a respective end portion of the plurality of linear patterns and wherein the plurality of linear patterns form a single loop antenna once the bonding portions are bonded.
A mobile machine comprising: a wheel for supporting the machine on a ground surface, the wheel including a tire defining an outer portion of the wheel; and a positioning receiver ; characterised in that the mobile machine further comprises: one or more computing devices configured to - determine a travel characteristic of the machine, determine a rotational speed ( ω w ) of the wheel, determine a radius ( R W ) of the tire based on the rotational speed of the wheel and the travel characteristic, and determine a height (H R ) of the positioning system receiver from the ground surface using the radius of the tire. a wheel for supporting the machine on a ground surface, the wheel including a tire defining an outer portion of the wheel; and a positioning receiver ; characterised in that the mobile machine further comprises: one or more computing devices configured to - determine a travel characteristic of the machine, determine a rotational speed ( ω w ) of the wheel, determine a radius ( R W ) of the tire based on the rotational speed of the wheel and the travel characteristic, and determine a height (H R ) of the positioning system receiver from the ground surface using the radius of the tire. determine a travel characteristic of the machine, determine a rotational speed ( ω w ) of the wheel, determine a radius ( R W ) of the tire based on the rotational speed of the wheel and the travel characteristic, and determine a height (H R ) of the positioning system receiver from the ground surface using the radius of the tire.