mhurhangee/patent-ind-claim-en huggingface dataset:
A computer-implemented method, comprising: collecting information associated with a user, the information including a dataset associated with the user, wherein the collecting of information associated with the user comprises: determining an access frequency of the user to the dataset during a period of time; and in response to the access frequency being below a predetermined threshold, determining the user as a target user for notification; automatically determining a preference of the user based on the collected information; in response to the dataset being updated, detecting an alert associated with a data change based on the determined preference of the user; and providing a notification associated with the detected alert to the user. collecting information associated with a user, the information including a dataset associated with the user, wherein the collecting of information associated with the user comprises: determining an access frequency of the user to the dataset during a period of time; and in response to the access frequency being below a predetermined threshold, determining the user as a target user for notification; determining an access frequency of the user to the dataset during a period of time; and in response to the access frequency being below a predetermined threshold, determining the user as a target user for notification; automatically determining a preference of the user based on the collected information; in response to the dataset being updated, detecting an alert associated with a data change based on the determined preference of the user; and providing a notification associated with the detected alert to the user.
A solenoid device including pressure altering means for altering an output pressure of the solenoid device ; and an actuator for providing an actuating signal to said pressure altering means ; wherein the solenoid device further includes a controller , wherein the solenoid device is a solenoid spool valve including a spool valve having a sleeve provided with a supply port , a control port , and a spool supported in the sleeve for axial displacement within the sleeve ; the actuator is an electromagnetic actuator for providing an axial drive force to said spool in a first axial direction, wherein the solenoid spool valve further includes a pressure sensor arranged to sense a control value of the spool valve , the control value being a control pressure, characterised in that the solenoid device is in the form of a module, including the pressure altering means, the actuator, the pressure sensor and the controller, and in that the controller receives a pressure request and is arranged to control delivery of power to the electromagnetic actuator with feedback from the pressure sensor until the control value meets the pressure request, wherein the controller is arranged to adaptively learn current provided to the electromagnetic actuator in relation to pressure sensed such that the solenoid spool valve is self-compensating for wear of the solenoid spool valve.
A service center , comprising: a processor readable medium comprising air removal instructions ; a service module comprising unsaturated printing fluid supplies ; and at least one adapter connected to the unsaturated printing fluid supplies , the at least one adapter being to connect with at least one fluid port of a printer , the fluid port being to receive a printing fluid, the at least one adapter connectable with the at least one fluid port when a regular printing fluid supply cartridge is removed from the fluid port ; characterized in that the processor-readable medium includes instructions to cause a processor to: introduce unsaturated printing fluid from the unsaturated printing fluid supplies into flow channels . a processor readable medium comprising air removal instructions ; a service module comprising unsaturated printing fluid supplies ; and at least one adapter connected to the unsaturated printing fluid supplies , the at least one adapter being to connect with at least one fluid port of a printer , the fluid port being to receive a printing fluid, the at least one adapter connectable with the at least one fluid port when a regular printing fluid supply cartridge is removed from the fluid port ; characterized in that the processor-readable medium includes instructions to cause a processor to: introduce unsaturated printing fluid from the unsaturated printing fluid supplies into flow channels .
An anti-PD-1 antibody or antigen-binding fragment thereof comprising: a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 73 (H-CDR1); the amino acid sequence of SEQ ID NO: 78 (H-CDR2); and the amino acid sequence of SEQ ID NO: 77 (H-CDR3), and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 165 (L-CDR1); the amino acid sequence of SEQ ID NO: 166 (L-CDR2); and the amino acid sequence of SEQ ID NO: 32 (L-CDR3). a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 73 (H-CDR1); the amino acid sequence of SEQ ID NO: 78 (H-CDR2); and the amino acid sequence of SEQ ID NO: 77 (H-CDR3), and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 165 (L-CDR1); the amino acid sequence of SEQ ID NO: 166 (L-CDR2); and the amino acid sequence of SEQ ID NO: 32 (L-CDR3).
An engineered ketoreductase polypeptide capable of converting (S)-tert-butyl 4-chloro-3-oxo-1-phenylbutan-2-ylcarbamate to tert-butyl -4-chloro-3-hydroxy-1-phenylbutan-2-ylcarbamate with a relative activity at least 1.2 fold that of SEQ ID NO:2, wherein the polypeptide comprises an amino acid sequence at least 70% identical to the full length of SEQ ID NO:2, and wherein residue corresponding to amino acid 190 of SEQ ID NO:2 is a nonpolar or an aliphatic amino acid selected from valine, alanine, leucine, isoleucine, and methionine.
A method of producing a product of a pathway of interest, the method comprising: (a) culturing in growth medium to a desired cell density cells genetically modified to comprise: (i) a HRV 3C protease coding sequence comprising a relocation sequence, and (ii) a coding sequence for at least one targeted enzyme that competes with an enzyme involved in a pathway of interest, wherein the coding sequence for the at least one targeted enzyme is genetically modified to comprise a HRV 3C protease recognition site, wherein the at least one targeted enzyme diverts/decelerates flux away from the product of interest, and/or wherein removal of the at least one targeted enzyme's enzymatic activities adversely affects cell growth; (b) lysing at least a portion of the cells to produce a cell lysate; and (c) combining the cell lysate with one or more substrates, enzymes, nutrients, co-factors, buffers, reducing agents, and/or ATP generation systems, whereby enzymes in the pathway of interest catalyze production of the product, and the HRV 3C protease cleaves the at least one targeted enzyme; and wherein the product is selected from the group consisting of antibiotics, biosurfactants, biological fuels, amino acids, organic acids, fatty acids, alcohols, polyols, flavors, fragrances, nucleotides, vitamins, pigments, sugars, polysaccharides, biopolymers, plastics, isoprenoids, and terpenes. (a) culturing in growth medium to a desired cell density cells genetically modified to comprise: (i) a HRV 3C protease coding sequence comprising a relocation sequence, and (ii) a coding sequence for at least one targeted enzyme that competes with an enzyme involved in a pathway of interest, wherein the coding sequence for the at least one targeted enzyme is genetically modified to comprise a HRV 3C protease recognition site, wherein the at least one targeted enzyme diverts/decelerates flux away from the product of interest, and/or wherein removal of the at least one targeted enzyme's enzymatic activities adversely affects cell growth; (b) lysing at least a portion of the cells to produce a cell lysate; and (c) combining the cell lysate with one or more substrates, enzymes, nutrients, co-factors, buffers, reducing agents, and/or ATP generation systems, whereby enzymes in the pathway of interest catalyze production of the product, and the HRV 3C protease cleaves the at least one targeted enzyme; and wherein the product is selected from the group consisting of antibiotics, biosurfactants, biological fuels, amino acids, organic acids, fatty acids, alcohols, polyols, flavors, fragrances, nucleotides, vitamins, pigments, sugars, polysaccharides, biopolymers, plastics, isoprenoids, and terpenes.
Apparatus for producing volume reflection holograms with substrate-guided reconstruction beams, comprising: - at least one transparent, planar carrier element with a first flat side (210.1) and a further flat side (210.2), - at least one master element arrangeable on the first flat side (210.1) of the carrier element and - at least one optical input coupling element designed for optically coupling in a light beam , - at least one coupling portion designed for mechanically establishing an optical contact between the input coupling element and at least one holographic recording medium providable on the further flat side (210.2) of the carrier element or designed for mechanically establishing an optical contact between the further flat side of the carrier element and at least one holographic recording medium providable on a flat side of the optical input coupling element , characterized in that - at least the coupling portion is formed from a material with a shear modulus of between 1000 Pa and 50 MPa, preferably of between 30000 Pa and 30 MPa. - at least one transparent, planar carrier element with a first flat side (210.1) and a further flat side (210.2), - at least one master element arrangeable on the first flat side (210.1) of the carrier element and - at least one optical input coupling element designed for optically coupling in a light beam , - at least one coupling portion designed for mechanically establishing an optical contact between the input coupling element and at least one holographic recording medium providable on the further flat side (210.2) of the carrier element or designed for mechanically establishing an optical contact between the further flat side of the carrier element and at least one holographic recording medium providable on a flat side of the optical input coupling element , characterized in that - at least the coupling portion is formed from a material with a shear modulus of between 1000 Pa and 50 MPa, preferably of between 30000 Pa and 30 MPa.
A handover, HO, method, comprising: performing, by a User Equipment, UE, measurement for a neighbor cell; when a preset reporting condition of a Measurement Report, MR, is met, reporting, by the UE, the MR to a source Radio Access Network, RAN, element; determining, by the source RAN element according to the MR, that system HO is required; sending, by the source RAN element, a HO request message to a first Core Network, CN, element, wherein the first CN element belongs to a first CN and is a source CN element; sending, by the first CN element, the HO request message to a second CN element, wherein the second CN element belongs to a second CN; determining, by the second CN element according to a service type of the UE, to keep, during a process of a handover of the UE from a source RAN to a target RAN, the connection between the source RAN and the first CN , wherein the source RAN element belongs to the source RAN, the source RAN belongs to the first CN and the target RAN belongs to the second CN, wherein the first CN is Evolved Packet Core, EPC, and the second CN is 5th-Generation, 5G, CN; sending, by the source RAN element, a HO command to the UE; sending, by the UE, a HO completion message to a target RAN element, wherein the target RAN element belongs to the target RAN, and the source RAN and the target RAN are different RANs; sending, by the target RAN element, a HO confirmation message to the source RAN element; and receiving, by the source RAN element, the HO confirmation message. performing, by a User Equipment, UE, measurement for a neighbor cell; when a preset reporting condition of a Measurement Report, MR, is met, reporting, by the UE, the MR to a source Radio Access Network, RAN, element; determining, by the source RAN element according to the MR, that system HO is required; sending, by the source RAN element, a HO request message to a first Core Network, CN, element, wherein the first CN element belongs to a first CN and is a source CN element; sending, by the first CN element, the HO request message to a second CN element, wherein the second CN element belongs to a second CN; determining, by the second CN element according to a service type of the UE, to keep, during a process of a handover of the UE from a source RAN to a target RAN, the connection between the source RAN and the first CN , wherein the source RAN element belongs to the source RAN, the source RAN belongs to the first CN and the target RAN belongs to the second CN, wherein the first CN is Evolved Packet Core, EPC, and the second CN is 5th-Generation, 5G, CN; sending, by the source RAN element, a HO command to the UE; sending, by the UE, a HO completion message to a target RAN element, wherein the target RAN element belongs to the target RAN, and the source RAN and the target RAN are different RANs; sending, by the target RAN element, a HO confirmation message to the source RAN element; and receiving, by the source RAN element, the HO confirmation message.
A rail surface cleaning system for cleaning a surface of rails of a rail system comprising a wheeled vehicle traveling on rails from contaminants , said system comprising: - a laser device designed to be mounted on said wheeled vehicle for generating a high intensity laser beam on said rail while said wheeled vehicle is travelling on said rail; - projection optics for projecting said beam as at least one laser spot on the contaminants , wherein the laser spot has a spot size, and - a control system for determining a longitudinal displacement speed (D) of said surface cleaning system with respect to said surface of said rails , and adapted for controlling said laser device and said projecting optics to result in a pattern of laser spots , said pattern comprising said laser spots with an energy of at least 0,5 Joule/cm 2 of each of said laser spots and have a spacing of up to the spot size when said rail surface cleaning system is applied on a train running on said rails with said train forming said wheeled vehicle travelling on said rails and said surface is a running surface of said rail , said rail surface cleaning system adapted to apply said pattern and said energy when said rail surface cleaning system runs at a speed (D) of at least 60 km/h with respect to said rails. - a laser device designed to be mounted on said wheeled vehicle for generating a high intensity laser beam on said rail while said wheeled vehicle is travelling on said rail; - projection optics for projecting said beam as at least one laser spot on the contaminants , wherein the laser spot has a spot size, and - a control system for determining a longitudinal displacement speed (D) of said surface cleaning system with respect to said surface of said rails , and adapted for controlling said laser device and said projecting optics to result in a pattern of laser spots , said pattern comprising said laser spots with an energy of at least 0,5 Joule/cm 2 of each of said laser spots and have a spacing of up to the spot size when said rail surface cleaning system is applied on a train running on said rails with said train forming said wheeled vehicle travelling on said rails and said surface is a running surface of said rail , said rail surface cleaning system adapted to apply said pattern and said energy when said rail surface cleaning system runs at a speed (D) of at least 60 km/h with respect to said rails.
Method for controlling of a biofilm, for removing of a formed biofilm and/or for controlling a growth of microorganisms, preferably bacteria, in an aqueous environment of an industrial manufacturing process comprising cellulosic fibre material, by administering to the aqueous environment of the process a composition comprising a compound according to Formula I where R1, R2 and R3 independently represent a hydrogen atom; halogen atom; hydroxy group; amino group; alkylamino group, alkyl group, hydroxyalkyl group, haloalkyl group or alkoxy group having 1 to 4 carbon atoms; or an acylamido group having 1 to 10 carbon atoms; and A represents 2-thiazolamine; 2-propenenitrile; 2-propenoic acid; alkyl ester or hydroxyalkyl ester of 2-propenoic acid having 1 to 4 carbon atoms; or - CHCHCONR5R6 group, where R5 and R6 represent independently hydrogen atom, alkyl or hydroxyalkyl having 1 to 4 carbon atoms, with the proviso that the said compound is not 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile or 4-amino-N-2-thiazolyl-benzenesulphonamide. R1, R2 and R3 independently represent a hydrogen atom; halogen atom; hydroxy group; amino group; alkylamino group, alkyl group, hydroxyalkyl group, haloalkyl group or alkoxy group having 1 to 4 carbon atoms; or an acylamido group having 1 to 10 carbon atoms; and A represents 2-thiazolamine; 2-propenenitrile; 2-propenoic acid; alkyl ester or hydroxyalkyl ester of 2-propenoic acid having 1 to 4 carbon atoms; or - CHCHCONR5R6 group, where R5 and R6 represent independently hydrogen atom, alkyl or hydroxyalkyl having 1 to 4 carbon atoms, with the proviso that the said compound is not 3-[(4-methylphenyl)sulphonyl]-2-propenenitrile or 4-amino-N-2-thiazolyl-benzenesulphonamide.
A method for producing a copper powder, the method comprising the steps of: heating a molten metal of copper to a temperature which is higher than the melting point of copper by 250 to 700 °C; and rapidly cooling and solidifying the heated molten metal by spraying a high-pressure water onto the heated molten metal in a non-oxidizing atmosphere while the heated molten metal is allowed to drop. heating a molten metal of copper to a temperature which is higher than the melting point of copper by 250 to 700 °C; and rapidly cooling and solidifying the heated molten metal by spraying a high-pressure water onto the heated molten metal in a non-oxidizing atmosphere while the heated molten metal is allowed to drop.
A garden pump comprising: a body ; a water channel adapted to allow flow of water through the pump , the water channel has an inlet and an outlet wherein the outlet allows to transport water to desired destinations such as gardens, lawns and the like; a device arranged with the body , the device is in contact with the water flowing through the water channel and is visible from outside the pump , for safe handling by a user during working of the garden pump ; characterized in that: the device is adapted to indicate temperature of water flowing through the water channel by exhibiting a color change, and wherein the device is a window adapted to inspect the water flowing through the water channel . a body ; a water channel adapted to allow flow of water through the pump , the water channel has an inlet and an outlet wherein the outlet allows to transport water to desired destinations such as gardens, lawns and the like; a device arranged with the body , the device is in contact with the water flowing through the water channel and is visible from outside the pump , for safe handling by a user during working of the garden pump ; characterized in that: the device is adapted to indicate temperature of water flowing through the water channel by exhibiting a color change, and wherein the device is a window adapted to inspect the water flowing through the water channel . the device is adapted to indicate temperature of water flowing through the water channel by exhibiting a color change, and wherein the device is a window adapted to inspect the water flowing through the water channel .
A robot arm comprising a joint mechanism for articulating one limb of the arm relative to another limb of the arm about two non-parallel rotation axes , the mechanism comprising: an intermediate carrier attached to a first one of the limbs by a first revolute joint having a first rotation axis and to a second one of the limbs by a second revolute joint having a second rotation axis ; a first drive gear disposed about the first rotation axis and fast with the carrier , whereby rotation of the carrier relative to the first limb about the first rotation axis can be driven; a second drive gear disposed about the second rotation axis and fast with the second one of the limbs , whereby rotation of the second one of the limbs about the second rotation axis relative to the carrier can be driven; at least one of the first and second drive gears being a sector gear; characterised in that the sector gear is a bevel gear. an intermediate carrier attached to a first one of the limbs by a first revolute joint having a first rotation axis and to a second one of the limbs by a second revolute joint having a second rotation axis ; a first drive gear disposed about the first rotation axis and fast with the carrier , whereby rotation of the carrier relative to the first limb about the first rotation axis can be driven; a second drive gear disposed about the second rotation axis and fast with the second one of the limbs , whereby rotation of the second one of the limbs about the second rotation axis relative to the carrier can be driven; at least one of the first and second drive gears being a sector gear; characterised in that the sector gear is a bevel gear.
A shroud for a gas turbine engine, the shroud comprising: a shroud body comprising a forward surface , a rear surface axially spaced from the forward surface, an inner surface extending between the forward surface and the rear surface, and an outer surface extending between the forward surface and the rear surface and radially spaced from the inner surface; a forward flange extending from the outer surface of the shroud body; a rear flange extending from the outer surface of the shroud body, the rear flange axially spaced from the forward flange; and a rib disposed between and in contact with the forward flange and the rear flange , characterized in that : the rib is spaced from the outer surface of the shroud body in the radial direction; the forward flange defines a bore hole ; the rear flange defines a bore hole ; and the bore hole in the forward flange and the bore hole in the rear flange are axially aligned for receiving, in use, a pin for attaching the shroud to a hanger. a shroud body comprising a forward surface , a rear surface axially spaced from the forward surface, an inner surface extending between the forward surface and the rear surface, and an outer surface extending between the forward surface and the rear surface and radially spaced from the inner surface; a forward flange extending from the outer surface of the shroud body; a rear flange extending from the outer surface of the shroud body, the rear flange axially spaced from the forward flange; and a rib disposed between and in contact with the forward flange and the rear flange , characterized in that : the rib is spaced from the outer surface of the shroud body in the radial direction; the forward flange defines a bore hole ; the rear flange defines a bore hole ; and the bore hole in the forward flange and the bore hole in the rear flange are axially aligned for receiving, in use, a pin for attaching the shroud to a hanger. the rib is spaced from the outer surface of the shroud body in the radial direction; the forward flange defines a bore hole ; the rear flange defines a bore hole ; and the bore hole in the forward flange and the bore hole in the rear flange are axially aligned for receiving, in use, a pin for attaching the shroud to a hanger.