An automated method for exchange of buffer solutions from admixtures comprising a buffer solution and a biological component, the method comprising: providing a pressure assembly , the pressure assembly comprising an upper housing and a lower housing , wherein the upper housing comprises: a pressure chamber ; a filtration unit within the pressure chamber for securing and filtering admixtures within a plurality of individual filtration reservoirs, the filtration unit comprising a receiver plate ; and a chamber door configured to seal the pressure chamber; placing the plurality of individual reservoirs, each comprising a semi-permeable membrane and containing an admixture comprising a biological component and a first buffer solution into the receiver plate of the filtration unit; pressurizing the pressure chamber by supplying air or an inert gas to a port , the port being in fluid communication with a pressure regulator and the pressure regulator being in fluid communication with a solenoid valve ; pressurizing the individual reservoirs within the pressure chamber to thereby force the first buffer solution through the semi-permeable membrane to produce a buffer-depleted residue, wherein a pressure relief valve is used to prevent over-pressurization of the system, and wherein the solenoid valve, pressure release valve and pressure regulator are disposed within the lower housing; detecting with a sensor an amount of the first buffer solution that was removed from each of the individual reservoirs; and adding a second buffer solution to the individual reservoirs, an amount of the second buffer solution added to the individual reservoirs being determined by the detected amount of the first buffer solution that was removed from each of the individual reservoirs. providing a pressure assembly , the pressure assembly comprising an upper housing and a lower housing , wherein the upper housing comprises: a pressure chamber ; a filtration unit within the pressure chamber for securing and filtering admixtures within a plurality of individual filtration reservoirs, the filtration unit comprising a receiver plate ; and a chamber door configured to seal the pressure chamber; a pressure chamber ; a filtration unit within the pressure chamber for securing and filtering admixtures within a plurality of individual filtration reservoirs, the filtration unit comprising a receiver plate ; and a chamber door configured to seal the pressure chamber; placing the plurality of individual reservoirs, each comprising a semi-permeable membrane and containing an admixture comprising a biological component and a first buffer solution into the receiver plate of the filtration unit; pressurizing the pressure chamber by supplying air or an inert gas to a port , the port being in fluid communication with a pressure regulator and the pressure regulator being in fluid communication with a solenoid valve ; pressurizing the individual reservoirs within the pressure chamber to thereby force the first buffer solution through the semi-permeable membrane to produce a buffer-depleted residue, wherein a pressure relief valve is used to prevent over-pressurization of the system, and wherein the solenoid valve, pressure release valve and pressure regulator are disposed within the lower housing; detecting with a sensor an amount of the first buffer solution that was removed from each of the individual reservoirs; and adding a second buffer solution to the individual reservoirs, an amount of the second buffer solution added to the individual reservoirs being determined by the detected amount of the first buffer solution that was removed from each of the individual reservoirs. <EOS>