A compound of formula Ia" or formula Id'' or a salt thereof, wherein: each bond designated represents a double bond that can optionally be cis, trans, or a mixture thereof W is sulfur, oxygen, or nitrogen; X, Y, and Z are individually carbon, or nitrogen, wherein at least two of X, Y, and Z are carbon; one of R 1 and R 2 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 1 -C 10 alkoxy, or aryloxy, wherein any C 1 -C 10 alkyl, or C 1 -C 10 alkoxy, is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy, and wherein any aryloxy is optionally substituted by at least one of halogen, or aryl, ; or one of R 1 and R 2 is a 5-6-membered saturated heterocycle and the other of R 1 and R 2 is absent; R 3 is absent, or is one of H, C 1 -C 2 alkyl, or halogen-substituted C 1 -C 2 alkyl; R 4 is absent, or is one of H, halogen, C 1 -C 2 alkyl, or halogen-substituted C 1 -C 2 alkyl; R 5 is H or M + , where M + is a pharmaceutically acceptable cation; R 6 is H, halogen, or methyl that is optionally substituted with halogen; R 9 is C 1 -C 10 alkyl or C 2 -C 10 alkenyl, wherein any C 1 -C 10 alkyl or C 2 -C 10 alkenyl is optionally substituted by at least one of halogen, hydroxy, alkoxy, or NR a R b ; R 10 is methyl that is substituted with 1, 2, or 3 deuterium atoms; one of R 12 and R 13 is hydrogen or C 1 -C 4 straight alkyl, and the other of R 12 and R 13 is C 1 -C 10 straight or branched alkyl, wherein an alkyl moiety of R 12 and R 13 optionally is substituted with 1-3 groups independently selected from halo each R a is C 1 -C 10 alkyl that is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy; and each R b is H or C 1 -C 10 alkyl that is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy. or a salt thereof, wherein: each bond designated represents a double bond that can optionally be cis, trans, or a mixture thereof W is sulfur, oxygen, or nitrogen; X, Y, and Z are individually carbon, or nitrogen, wherein at least two of X, Y, and Z are carbon; one of R 1 and R 2 is C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 1 -C 10 alkoxy, or aryloxy, wherein any C 1 -C 10 alkyl, or C 1 -C 10 alkoxy, is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy, and wherein any aryloxy is optionally substituted by at least one of halogen, or aryl, ; or one of R 1 and R 2 is a 5-6-membered saturated heterocycle and the other of R 1 and R 2 is absent; R 3 is absent, or is one of H, C 1 -C 2 alkyl, or halogen-substituted C 1 -C 2 alkyl; R 4 is absent, or is one of H, halogen, C 1 -C 2 alkyl, or halogen-substituted C 1 -C 2 alkyl; R 5 is H or M + , where M + is a pharmaceutically acceptable cation; R 6 is H, halogen, or methyl that is optionally substituted with halogen; R 9 is C 1 -C 10 alkyl or C 2 -C 10 alkenyl, wherein any C 1 -C 10 alkyl or C 2 -C 10 alkenyl is optionally substituted by at least one of halogen, hydroxy, alkoxy, or NR a R b ; R 10 is methyl that is substituted with 1, 2, or 3 deuterium atoms; one of R 12 and R 13 is hydrogen or C 1 -C 4 straight alkyl, and the other of R 12 and R 13 is C 1 -C 10 straight or branched alkyl, wherein an alkyl moiety of R 12 and R 13 optionally is substituted with 1-3 groups independently selected from halo each R a is C 1 -C 10 alkyl that is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy; and each R b is H or C 1 -C 10 alkyl that is optionally substituted by at least one of halogen, hydroxy, or C 1 -C 5 alkoxy. <EOS>