A kit for determining an analyte in a sample, wherein the sample is a body fluid sample, comprising: (a) a sampling device configured for taking up a sample, wherein the sample is a body fluid sample, containing an analyte, wherein the sampling device comprises a sample matrix and optionally an eluent for eluting the analyte from the sample matrix and (b) an analysis device , comprising (i) a first region which is configured for introducing the sampling device, (ii) optionally an eluent for eluting the analyte from the sampling device, (iii) a second region which is configured for detecting the presence and/or amount of the analyte in a solution comprising at least the analyte eluted from the sample matrix and the eluent by means of surface enhanced Raman spectroscopy, and (iv)optionally a housing , wherein at least one of the sampling device and the analysis device comprises an eluent and at least one of the sampling device and the analysis device comprises SERS active particles , wherein the eluent present in the sampling device and/or in the analysis device comprises SERS-active nanoparticles dispersed therein and/or wherein the second region comprises SERS-active nanoparticles , wherein the SERS-active nanoparticles are dry SERS-active nanoparticles . (a) a sampling device configured for taking up a sample, wherein the sample is a body fluid sample, containing an analyte, wherein the sampling device comprises a sample matrix and optionally an eluent for eluting the analyte from the sample matrix and (b) an analysis device , comprising (i) a first region which is configured for introducing the sampling device, (ii) optionally an eluent for eluting the analyte from the sampling device, (iii) a second region which is configured for detecting the presence and/or amount of the analyte in a solution comprising at least the analyte eluted from the sample matrix and the eluent by means of surface enhanced Raman spectroscopy, and (iv)optionally a housing , wherein at least one of the sampling device and the analysis device comprises an eluent and at least one of the sampling device and the analysis device comprises SERS active particles , wherein the eluent present in the sampling device and/or in the analysis device comprises SERS-active nanoparticles dispersed therein and/or wherein the second region comprises SERS-active nanoparticles , wherein the SERS-active nanoparticles are dry SERS-active nanoparticles . (i) a first region which is configured for introducing the sampling device, (ii) optionally an eluent for eluting the analyte from the sampling device, (iii) a second region which is configured for detecting the presence and/or amount of the analyte in a solution comprising at least the analyte eluted from the sample matrix and the eluent by means of surface enhanced Raman spectroscopy, and (iv)optionally a housing , wherein at least one of the sampling device and the analysis device comprises an eluent and at least one of the sampling device and the analysis device comprises SERS active particles , wherein the eluent present in the sampling device and/or in the analysis device comprises SERS-active nanoparticles dispersed therein and/or wherein the second region comprises SERS-active nanoparticles , wherein the SERS-active nanoparticles are dry SERS-active nanoparticles . <EOS>