An isothermal titration micro calorimetry (ITC) system , comprising: a microcalorimeter with a sample cell and a reference cell , the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem ; and characterized by an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant and a fill port at an upper section of the syringe , providing fluidic contact with the syringe cavity when the plunger is positioned above the fill port , the pipette assembly comprising an activator for driving a plunger in the syringe , a fill port connection unit comprising a connection member configured to connect to the fill port thereby enabling fluid to transfer into the cavity of the syringe , a pipette translation unit comprising a pipette arm that is supported for rotation about an axis (A), supports the pipette assembly at its other end and is further arranged to move the pipette assembly vertically, the pipette translation unit being arranged to place the pipette assembly in position for titration, washing and filling operations; a wash station for the titrant needle ; and a cell fluidics system for dispensing and withdrawing liquid in the sample cell ; and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette assembly is placed in another position than the position for titration, the cell preparation unit comprising a cell arm that is supported for rotation about an axis (B), supporting a cell cannula connected to the cell fluidics system . a microcalorimeter with a sample cell and a reference cell , the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem ; and characterized by an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant and a fill port at an upper section of the syringe , providing fluidic contact with the syringe cavity when the plunger is positioned above the fill port , the pipette assembly comprising an activator for driving a plunger in the syringe , a fill port connection unit comprising a connection member configured to connect to the fill port thereby enabling fluid to transfer into the cavity of the syringe , a pipette translation unit comprising a pipette arm that is supported for rotation about an axis (A), supports the pipette assembly at its other end and is further arranged to move the pipette assembly vertically, the pipette translation unit being arranged to place the pipette assembly in position for titration, washing and filling operations; a wash station for the titrant needle ; and a cell fluidics system for dispensing and withdrawing liquid in the sample cell ; and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette assembly is placed in another position than the position for titration, the cell preparation unit comprising a cell arm that is supported for rotation about an axis (B), supporting a cell cannula connected to the cell fluidics system . <EOS>