mhurhangee/patent-ind-claim-en huggingface dataset:
A method of skipping a target exon 45 of a human dystrophin gene in a genome, comprising using CRISPR-Cas and guide RNA, wherein the guide RNA contains a spacer sequence such that the site of cleavage by the CRISPR-Cas is positioned within 80 bases from the splice acceptor site immediately before the target exon or the splice donor site immediately after the target exon, wherein two or more kinds of the guide RNA are used, and wherein the spacer sequences of the two or more kinds of guide RNA include the combinations of sgRNA-DMD1 (the base sequence of bases from 17 to 36 in SEQ ID NO: 17), sgRNA-DMD2 (the base sequence of bases from 17 to 36 in SEQ ID NO: 18), sgRNA-DMD4 (the base sequence of bases from 17 to 36 in SEQ ID NO:20), sgRNA-DMD8 (the base sequence of bases from 17 to 36 in SEQ ID NO:24), or sgRNA-DMD9 (the base sequence of bases from 17 to 36 in SEQ ID NO:25) with sgRNA-DMD23 (the base sequence of bases from 17 to 36 in SEQ ID NO:39) or sgRNA-DMD20 (the base sequence of bases from 17 to 36 in SEQ ID N°36) wherein the method is not a method of treatment of the human/animal body by therapy and wherein the method is not a process for modifying the germ line genetic identity of human beings.
Pneumatic vehicle tyre having a profiled tread with a tread depth defined in the case of a new tyre and having profile blocks or profile ribs with in each case at least one incision (2, 2', 2", 2′′′, 2ʺʺ) on the outer surfaces of the tread periphery; which in top view extends at an angle of up to 50° to the axial direction, in at least one portion (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2ʺʺa, 2ʺʺb) has a depth (t) of at least 60% of the profile depth and is delimited by two incision walls (3a, 3b, 3'a, 3'b, 3"a , 3"b, 3′′′a, 3′′′b, 3ʺʺa, 3ʺʺb), wherein in this portion (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2ʺʺa, 2ʺʺb) the one incision wall (3a, 3'a, 3"a, 3′′′a, 3ʺʺa, or 3b, 3'b, 3"b, 3′′′b, 3""b) extends in the radial direction and the other incision wall (3a, 3'a, 3"a, 3′′′a, 3""a or 3b, 3'b, 3"b, 3′′′b, 3""b) extends straight and at a constant acute angle (a) of 1° to 6° to the radial direction in such a way that the width of the incision (2, 2', 2", 2′′′, 2ʺʺ) in this portion (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2ʺʺa, 2ʺʺb) continuously decreases in the radial direction between the outer surface and the incision base (3′′′c, 3ʺʺc), characterized in that the incision (2, 2', 2", 2′′′, 2"") has an in particular constant width (b 1 ) of 0.40 mm to 1.50 mm on the respective outer surface of the profile block or the profile rib, wherein the incision (2, 2', 2", 2′′′, 2"") in its direction of extent has a plurality of incision portions (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2""a, 2""b), in which it is delimited by the two incision walls (3a, 3'a, 3"a, 3′′′a, 3""a or 3b, 3'b, 3"b, 3′′′b, 3""b) in such a manner that within each incision portion (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2""a, 2""b) at least in portions the one extends in the radial direction, and the other extends at the acute angle (α) to the radial direction, and wherein in the direction of extent of the incision (2, 2', 2", 2′′′, 2ʺʺ) in successive incision portions (2a, 2b, 2'a, 2'b, 2"a, 2"b, 2′′′a, 2′′′b, 2""a, 2""b) the inclination of the incision walls (3a, 3'a, 3"a, 3′′′a, 3""a or 3b, 3'b, 3"b, 3′′′b, 3""b) alternates to the radial direction.
A multilayer polymeric film, comprising a first skin layer, a second skin layer, and an intermediate layer, wherein the first skin layer is formed of a first polymer composition, the second skin layer is formed of a second polymer composition, and the intermediate layer is formed of a third polymer composition, wherein each of the first, second and third polymer compositions comprises a base polymer which is a polyolefin; wherein each respective layer has distributed therein particles of titanium dioxide of from 6 percent to 14 percent, more preferably from 8 percent to 12 percent, and even more preferably from 9 percent to 11 percent of the weight of the respective layer; wherein the second skin layer has further distributed therein non-white pigment particles of from 0.050 percent to 0.15 percent, of the weight of the second skin layer; and characterized in that the first skin layer comprises no more than 0.050 percent by weight of non-white pigment particles distributed therein, wherein the non-white pigment particles are inorganic pigment particles selected from the group consisting of cobalt blue, cerulean blue, Han blue, Egyptian blue, phthalo blue, Prussian blue, ultramarine, ultramarine violet, Han purple, cobalt violet and manganese violet, and combinations thereof. wherein the first skin layer is formed of a first polymer composition, the second skin layer is formed of a second polymer composition, and the intermediate layer is formed of a third polymer composition, wherein each of the first, second and third polymer compositions comprises a base polymer which is a polyolefin; wherein each respective layer has distributed therein particles of titanium dioxide of from 6 percent to 14 percent, more preferably from 8 percent to 12 percent, and even more preferably from 9 percent to 11 percent of the weight of the respective layer; wherein the second skin layer has further distributed therein non-white pigment particles of from 0.050 percent to 0.15 percent, of the weight of the second skin layer; and characterized in that the first skin layer comprises no more than 0.050 percent by weight of non-white pigment particles distributed therein, wherein the non-white pigment particles are inorganic pigment particles selected from the group consisting of cobalt blue, cerulean blue, Han blue, Egyptian blue, phthalo blue, Prussian blue, ultramarine, ultramarine violet, Han purple, cobalt violet and manganese violet, and combinations thereof.
An influenza hemagglutinin stem domain polypeptide comprising the amino acid sequence: wherein X 1 is K, X 2 is K, X 3 is F, X 4 is T, X 5 is M, X 6 is Y, X 7 is I, X 8 is Y, and X 9 is S.
A gas turbine engine comprising: a rotor carrying a blade ; a ceramic vane adjacent the blade ; a seal carried on the rotor adjacent a tip of the ceramic vane ; and a cooling passage circuit extending through the blade , the seal , and the ceramic vane , the cooling passage circuit configured to provide cooling air into the blade , then from the blade into the seal , and then from the seal into the ceramic vane . a rotor carrying a blade ; a ceramic vane adjacent the blade ; a seal carried on the rotor adjacent a tip of the ceramic vane ; and a cooling passage circuit extending through the blade , the seal , and the ceramic vane , the cooling passage circuit configured to provide cooling air into the blade , then from the blade into the seal , and then from the seal into the ceramic vane .
An identification document having a substrate and having a security feature that is perceptible as an optical marking at least from one side of the substrate , the marking comprising at least one black fraction and at least one colored fraction , the black fraction being visible at least when illuminated with light having a normal spectral distribution, and the colored fraction being formed by a color that can be excited to shine under UV light and that is visible substantially only when illuminated with UV light, the black fraction being formed by an integrated engraving in the substrate , characterized in that the black fraction and the colored fraction are formed to be in register with each other and together forming, under illumination with UV light, a orthochromatic image, namely a color photograph of a person.
An ultrasound diagnosis apparatus comprising: a display ; a memory storing one or more instructions; and at least one processor configured to execute the stored one or more instructions to: acquire three-dimensional ultrasound volume data regarding a region of interest of an object ; identify a plurality of two-dimensional cross-sectsions , each including at least one feature to be observed, based on the 3D ultrasound volume data ; determine priority levels of the plurality of 2D cross-sections based on the at least one feature included in each of the plurality of 2D cross-sections ; and control the display to display a plurality of 2D ultrasound images respectively corresponding to at least some of the plurality of 2D cross-sections based on the priority levels, wherein the at least one processor is further configured to execute the stored one of more instructions to acquire an area and a number of portions including the at least one feature in each of the plurality of 2D cross-sections and determine the priority levels of the plurality of 2D cross-sections based on at least one of the area and the number. a display ; a memory storing one or more instructions; and at least one processor configured to execute the stored one or more instructions to: acquire three-dimensional ultrasound volume data regarding a region of interest of an object ; identify a plurality of two-dimensional cross-sectsions , each including at least one feature to be observed, based on the 3D ultrasound volume data ; determine priority levels of the plurality of 2D cross-sections based on the at least one feature included in each of the plurality of 2D cross-sections ; and control the display to display a plurality of 2D ultrasound images respectively corresponding to at least some of the plurality of 2D cross-sections based on the priority levels, wherein the at least one processor is further configured to execute the stored one of more instructions to acquire an area and a number of portions including the at least one feature in each of the plurality of 2D cross-sections and determine the priority levels of the plurality of 2D cross-sections based on at least one of the area and the number. acquire three-dimensional ultrasound volume data regarding a region of interest of an object ; identify a plurality of two-dimensional cross-sectsions , each including at least one feature to be observed, based on the 3D ultrasound volume data ; determine priority levels of the plurality of 2D cross-sections based on the at least one feature included in each of the plurality of 2D cross-sections ; and control the display to display a plurality of 2D ultrasound images respectively corresponding to at least some of the plurality of 2D cross-sections based on the priority levels, wherein the at least one processor is further configured to execute the stored one of more instructions to acquire an area and a number of portions including the at least one feature in each of the plurality of 2D cross-sections and determine the priority levels of the plurality of 2D cross-sections based on at least one of the area and the number.
A structural support system, comprising: a top plate comprising one or more openings configured to receive elongated piles ; a locking component configured to be connected to said top plate by one or more connectors, comprising a tightening mechanism operable to develop a compression force between said top plate and said locking component; wherein said locking component is configured to lock said elongated piles within said one or more openings when said tightening mechanism is utilized such that the distance between said top plate and said locking component is reduced by said compression force thereby locking said elongated piles in said one or more openings. a top plate comprising one or more openings configured to receive elongated piles ; a locking component configured to be connected to said top plate by one or more connectors, comprising a tightening mechanism operable to develop a compression force between said top plate and said locking component; wherein said locking component is configured to lock said elongated piles within said one or more openings when said tightening mechanism is utilized such that the distance between said top plate and said locking component is reduced by said compression force thereby locking said elongated piles in said one or more openings.
A weighing hood for weighing pharmaceutically active or toxic substances in a laboratory, comprising: a housing , which defines a work space , wherein a front surface of the housing has a work opening that is always open in an intended use of the weighing hood , a work surface , which delimits the floor of the work space , an armrest in the region of the work opening , and a support , which supports the weight of the housing , the work surface , and the armrest , characterised in that the work surface in an intended use of the weighing hood is decoupled from the housing , the armrest , and the support with regard to impacts and vibrations. a housing , which defines a work space , wherein a front surface of the housing has a work opening that is always open in an intended use of the weighing hood , a work surface , which delimits the floor of the work space , an armrest in the region of the work opening , and a support , which supports the weight of the housing , the work surface , and the armrest , characterised in that the work surface in an intended use of the weighing hood is decoupled from the housing , the armrest , and the support with regard to impacts and vibrations.
A thermowell assembly for use in measuring a temperature of a process fluid , comprising: elongate thermowell body configured to mount to a process vessel and extend into the process fluid contained in the process vessel ; an elongate bore extended along a length of the elongate thermowell body from a proximal end of the elongate thermowell body proximate a wall of the process vessel to a sealed distal end of the elongate thermowell body positioned in the process fluid ; a side bore extending from an exterior of the thermowell assembly to the elongate bore , the side bore positioned outside of the process vessel ; and a verification valve having an inlet coupled to the side bore at the exterior of the thermowell assembly and having an outlet whereby an operator can determine a presence of process fluid in the elongate bore by opening the verification valve and observing process fluid at the outlet of the verification valve ; and characterized in that the verification valve includes a visual indicator which indicates presence of a pressure within the elongate bore , wherein the visual indicator changes shape in response to applied pressure. elongate thermowell body configured to mount to a process vessel and extend into the process fluid contained in the process vessel ; an elongate bore extended along a length of the elongate thermowell body from a proximal end of the elongate thermowell body proximate a wall of the process vessel to a sealed distal end of the elongate thermowell body positioned in the process fluid ; a side bore extending from an exterior of the thermowell assembly to the elongate bore , the side bore positioned outside of the process vessel ; and a verification valve having an inlet coupled to the side bore at the exterior of the thermowell assembly and having an outlet whereby an operator can determine a presence of process fluid in the elongate bore by opening the verification valve and observing process fluid at the outlet of the verification valve ; and characterized in that the verification valve includes a visual indicator which indicates presence of a pressure within the elongate bore , wherein the visual indicator changes shape in response to applied pressure.
Method for managing the longitudinal speed of a first vehicle , comprising: - a step (E1) of detecting vehicles in nearby traffic, the first vehicle comprising detecting at least one vehicle ahead of the first vehicle and at least one vehicle behind the first vehicle, - a step (E2) of calculating reference speeds, comprising calculating at least a first reference speed on the basis of the at least one vehicle ahead of the first vehicle and calculating at least a second reference speed on the basis of the at least one vehicle behind the first vehicle, characterized in that the method comprises - a step (E3) of calculating a maximum speed setpoint (CMAX) on the basis of the first reference speed, - a step (E4) of calculating a minimum speed setpoint (CMIN) on the basis of the second reference speed, - a step (E5) of calculating a speed setpoint of the first vehicle, the speed setpoint of the first vehicle (CVL) being less than or equal to said maximum speed setpoint (CMAX) and greater than or equal to said minimum speed setpoint (CMIN). - a step (E1) of detecting vehicles in nearby traffic, the first vehicle comprising detecting at least one vehicle ahead of the first vehicle and at least one vehicle behind the first vehicle, - a step (E2) of calculating reference speeds, comprising calculating at least a first reference speed on the basis of the at least one vehicle ahead of the first vehicle and calculating at least a second reference speed on the basis of the at least one vehicle behind the first vehicle, characterized in that the method comprises - a step (E3) of calculating a maximum speed setpoint (CMAX) on the basis of the first reference speed, - a step (E4) of calculating a minimum speed setpoint (CMIN) on the basis of the second reference speed, - a step (E5) of calculating a speed setpoint of the first vehicle, the speed setpoint of the first vehicle (CVL) being less than or equal to said maximum speed setpoint (CMAX) and greater than or equal to said minimum speed setpoint (CMIN).
A method of producing an optical fiber comprising: providing a porous soot cladding monolith , said soot cladding monolith including a first porous glass cladding layer and having an internal cavity ; inserting a core cane into said internal cavity to form a core-cladding assembly, said core-cladding assembly including a channel between said core cane and said soot cladding monolith; exposing said core-cladding assembly to a first gas atmosphere at a first temperature, said first gas atmosphere comprising a chlorine source material, said chlorine source material providing chlorine for doping said first porous glass cladding layer; exposing said core-cladding assembly to a second gas atmosphere at a second temperature, said second gas atmosphere comprising a reducing agent; and heating said core-cladding assembly in the presence of said second gas atmosphere at a third temperature, said heating causing sintering of said first porous glass cladding layer, said sintered first porous glass cladding layer having a chlorine dopant concentration of at least 500 ppm by weight; and drawing a fiber. providing a porous soot cladding monolith , said soot cladding monolith including a first porous glass cladding layer and having an internal cavity ; inserting a core cane into said internal cavity to form a core-cladding assembly, said core-cladding assembly including a channel between said core cane and said soot cladding monolith; exposing said core-cladding assembly to a first gas atmosphere at a first temperature, said first gas atmosphere comprising a chlorine source material, said chlorine source material providing chlorine for doping said first porous glass cladding layer; exposing said core-cladding assembly to a second gas atmosphere at a second temperature, said second gas atmosphere comprising a reducing agent; and heating said core-cladding assembly in the presence of said second gas atmosphere at a third temperature, said heating causing sintering of said first porous glass cladding layer, said sintered first porous glass cladding layer having a chlorine dopant concentration of at least 500 ppm by weight; and drawing a fiber.
A kitchen appliance comprising: a main housing having a handle grip portion ; a motor within the housing for driving a rotary food processing member; a speed control circuit in the housing for controlling the speed of the motor by controlling the power supplied to the motor; a manual speed control element for operating the speed control circuit to set the motor speed to one from a corresponding range of motor speeds; and a visual display on the main housing remote from the manual speed control element and facing the user in use, characterized in that a mechanical linkage is provided between the manual speed control element and the visual display , the visual display indicating the power supplied to the motor based on the amount of actuation of the manual speed control element . a main housing having a handle grip portion ; a motor within the housing for driving a rotary food processing member; a speed control circuit in the housing for controlling the speed of the motor by controlling the power supplied to the motor; a manual speed control element for operating the speed control circuit to set the motor speed to one from a corresponding range of motor speeds; and a visual display on the main housing remote from the manual speed control element and facing the user in use, characterized in that a mechanical linkage is provided between the manual speed control element and the visual display , the visual display indicating the power supplied to the motor based on the amount of actuation of the manual speed control element .
An oscillating power tool , which power tool comprises a clamp arrangement for securing an accessory to the power tool ; wherein the clamp arrangement comprises a clamp assembly including a first clamp member arranged to move relative to a second clamp member of the clamp assembly ; wherein the first clamp member is rotated to translate between a closed position wherein the clamp assembly retains the accessory and an open position wherein the first clamp member is offset from the accessory permitting removal of the accessory from the clamp assembly while the first clamp member remains coupled to the clamp assembly ; wherein the clamp assembly comprises a stem , a cam mechanism and a biasing member , wherein the biasing member acts on the first clamp member with the first clamp member being influenced by the cam mechanism , such that when the first clamp member is in the closed position, the biasing member and the cam mechanism are configured to act to retain the first clamp member in engagement with an attachment portion of the accessory held between the first clamp member and the second clamp member such that the accessory cannot be detached from the first and second clamp members unless and until the cam mechanism is moved, against the force of the biasing member to translate the first clamp member along the axis of the stem upon rotation into the open position, thereby permitting detachment of the accessory from the power tool .
A datapage for an identification booklet comprising a data sheet and a connecting element fastened to the data sheet , wherein each of the data sheet and the connecting element has main surfaces and edges extending between said main surfaces, with said edges being rectangular and flat, wherein an edge of the connecting element is fastened side by side to an edge of the data sheet , the datapage being characterized in that the connecting element has a thickness which decreases from a part extending from the edge of the data sheet to a part of nominal thickness of the connecting element .