A closure device for closing a tissue opening, comprising: one or more closure components, each closure component comprising a first member and a second member ; each of the first and second members (310; 310) having a body, a first surface (320; 320) that are suitable to adhere to a tissue surface proximate to the tissue opening, the first surface having at least one adhesive; wherein each of the first and second members (310; 310) have a second surface (322; 322) wherein at least one alignment member is positioned, the at least one alignment member extending from a body of each of the respective first and second member (310; 310); and the second surface and body of each respective first and second member (310; 310) being further structured to receive the at least one alignment member of the other first or second member each of the first and second members (310; 310) having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members (310; 310)by the engagement of the at least one alignment member , wherein the alignment members (315; 315)are ratchet mechanisms including a plurality of teeth , characterised in that the teeth are non-uniform in height. one or more closure components, each closure component comprising a first member and a second member ; each of the first and second members (310; 310) having a body, a first surface (320; 320) that are suitable to adhere to a tissue surface proximate to the tissue opening, the first surface having at least one adhesive; wherein each of the first and second members (310; 310) have a second surface (322; 322) wherein at least one alignment member is positioned, the at least one alignment member extending from a body of each of the respective first and second member (310; 310); and the second surface and body of each respective first and second member (310; 310) being further structured to receive the at least one alignment member of the other first or second member each of the first and second members (310; 310) having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members (310; 310)by the engagement of the at least one alignment member , wherein the alignment members (315; 315)are ratchet mechanisms including a plurality of teeth , characterised in that the teeth are non-uniform in height. each of the first and second members (310; 310) have a second surface (322; 322) wherein at least one alignment member is positioned, the at least one alignment member extending from a body of each of the respective first and second member (310; 310); and the second surface and body of each respective first and second member (310; 310) being further structured to receive the at least one alignment member of the other first or second member a second surface (322; 322) wherein at least one alignment member is positioned, the at least one alignment member extending from a body of each of the respective first and second member (310; 310); and the second surface and body of each respective first and second member (310; 310) being further structured to receive the at least one alignment member of the other first or second member each of the first and second members (310; 310) having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members (310; 310)by the engagement of the at least one alignment member , wherein the alignment members (315; 315)are ratchet mechanisms including a plurality of teeth , characterised in that the teeth are non-uniform in height. <EOS>