mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody capable of being selectively activated in a target cell or tissue to treat a condition therein, comprising: a functional antibody capable of treating the condition in an activated state, comprising two light chains and two heavy chains; two inhibitory domains, wherein each inhibitory domain is a hinge domain of an immunoglobulin A (IgA), immunoglobulin D (IgD) or an immunoglobulin G (IgG), or a fragment of the hinge domain of IgA, IgD or IgG, and wherein each inhibitory domain consists of two peptide arms interconnected by disulfide bonds; and four cleavable linkers, wherein each cleavable linker comprises a peptide substrate cleavable by an enzyme that is specifically or highly expressed in the target cell or tissue, and wherein each cleavable linker separately connects one of the two peptide arms of each of the two inhibitory domains to each of the N-terminals of one of the two light chains and two heavy chains of the functional antibody. a functional antibody capable of treating the condition in an activated state, comprising two light chains and two heavy chains; two inhibitory domains, wherein each inhibitory domain is a hinge domain of an immunoglobulin A (IgA), immunoglobulin D (IgD) or an immunoglobulin G (IgG), or a fragment of the hinge domain of IgA, IgD or IgG, and wherein each inhibitory domain consists of two peptide arms interconnected by disulfide bonds; and four cleavable linkers, wherein each cleavable linker comprises a peptide substrate cleavable by an enzyme that is specifically or highly expressed in the target cell or tissue, and wherein each cleavable linker separately connects one of the two peptide arms of each of the two inhibitory domains to each of the N-terminals of one of the two light chains and two heavy chains of the functional antibody.
Carrying device for a vibration plate for ground compaction, comprising - a gripping device having a gripping region for gripping with at least one hand by a user; and comprising - a fastening device for fastening the carrying device to the vibration plate; characterised by - a sprinkling device for outputting water; wherein - the gripping device , the sprinkling device and the fastening device are formed in one piece in a common component. - a gripping device having a gripping region for gripping with at least one hand by a user; and comprising - a fastening device for fastening the carrying device to the vibration plate; - a sprinkling device for outputting water; - the gripping device , the sprinkling device and the fastening device are formed in one piece in a common component.
A method of operating an HVAC system, the method comprising the following steps performed by a controller comprising a central processing unit and memory: predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off ; determining if the first predicted temperature is less than a set-point temperature ; characterized in responsive to a determination that the first predicted temperature is less than the set-point temperature, predicting a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime ; determining if the second predicted temperature is less than the set-point temperature ; and responsive to a determination that the second predicted temperature is not less than the set-point temperature, operating the HVAC system for the first runtime ; responsive to a determination that the second predicted temperature is less than the set-point temperature, repeating, for an increased runtime, the step of predicting a second predicted temperature and the step of determining if the second predicted temperature is less than the set-point temperature ; and continuing the repeating until the second predicted temperature is not less than the set-point temperature. predicting a first predicted temperature of an enclosed space during an unoccupied time with the HVAC system off ; determining if the first predicted temperature is less than a set-point temperature ; characterized in responsive to a determination that the first predicted temperature is less than the set-point temperature, predicting a second predicted temperature of the enclosed space if the HVAC system is operated for a first runtime ; determining if the second predicted temperature is less than the set-point temperature ; and responsive to a determination that the second predicted temperature is not less than the set-point temperature, operating the HVAC system for the first runtime ; responsive to a determination that the second predicted temperature is less than the set-point temperature, repeating, for an increased runtime, the step of predicting a second predicted temperature and the step of determining if the second predicted temperature is less than the set-point temperature ; and continuing the repeating until the second predicted temperature is not less than the set-point temperature.
A laundry treating apparatus comprising: a cabinet having an opening at a front side; a tub installed inside the cabinet ; a drum rotatably installed inside the tub , wherein the drum has a front face opened to put laundry into the drum therethrough and a rear face coupled to a rotation shaft extending in a front and rear direction; a detergent storage unit entered into rearwardly or drawn out forwardly from the cabinet through the opening , wherein the detergent storage unit includes a detergent container for containing the detergent therein, and a detergent outlet for discharging the detergent of the detergent container therethrough; a supply casing disposed in the cabinet and receiving the detergent storage unit entered through the opening ; a dispenser disposed inside the cabinet , and located above the detergent storage unit , wherein the dispenser includes a water supply portion from which water is discharged and drops downwards, characterized in that : the water supply portion includes a shower portion discharging water between a side wall of the supply casing and the detergent storage unit based on a width direction transverse to the front and rear direction so as to supply water to a bottom of the supply casing , and the shower portion includes a front shower portion that is configured to discharge water in front of the detergent outlet . a cabinet having an opening at a front side; a tub installed inside the cabinet ; a drum rotatably installed inside the tub , wherein the drum has a front face opened to put laundry into the drum therethrough and a rear face coupled to a rotation shaft extending in a front and rear direction; a detergent storage unit entered into rearwardly or drawn out forwardly from the cabinet through the opening , wherein the detergent storage unit includes a detergent container for containing the detergent therein, and a detergent outlet for discharging the detergent of the detergent container therethrough; a supply casing disposed in the cabinet and receiving the detergent storage unit entered through the opening ; a dispenser disposed inside the cabinet , and located above the detergent storage unit , wherein the dispenser includes a water supply portion from which water is discharged and drops downwards, characterized in that : the water supply portion includes a shower portion discharging water between a side wall of the supply casing and the detergent storage unit based on a width direction transverse to the front and rear direction so as to supply water to a bottom of the supply casing , and the shower portion includes a front shower portion that is configured to discharge water in front of the detergent outlet . the water supply portion includes a shower portion discharging water between a side wall of the supply casing and the detergent storage unit based on a width direction transverse to the front and rear direction so as to supply water to a bottom of the supply casing , and the shower portion includes a front shower portion that is configured to discharge water in front of the detergent outlet .
Pneumatic vehicle tyre, in particular utility-vehicle tyre, having a tread with a number of profile ribs which are separated from one another by circumferential channels , wherein the tread has at least one circumferential channel which, in a radial direction starting at the tread periphery, is made up of an outer channel (7`), which extends with a waveform that is present exclusively in a circumferential direction, and of an inner channel , which, at its widest point, has a width (b 1 ) which is at least 1.00 mm greater than the width (b 2 ) of a portion (7'b) of the outer channel that directly adjoins the inner channel , wherein the widths (b 1 , b 2 ) are in each case determined at the points with the greatest width, and wherein the outer channel is made up in the radial direction of an outer portion (7'a), which is widened in a funnel-like manner at the tread periphery, and of the portion (7'b) adjoining the inner channel , characterized in that , at the tread periphery, the outer portion (7'a) widened in a funnel-like manner has a width (b 3 ) which corresponds at most to the width (b 1 ) of the inner channel .
Method for operating a steam generator with a feed water supply by means of a feed water pump into a steam drum , an evaporator and a natural circulation of a water-steam mixture in a down pipe and a steam discharge pipe , wherein the steam generator is operated in the temperature equilibrium between drum-steam, drum-water and downpipe water, characterised in that - a media temperature of the water-steam mixture coming from the evaporator in the steam discharge pipe measured by means of measuring device at, at least, one point before entering the steam drum is measured by means of sensors in immersion sleeves, - a boiling temperature is measured or calculated in the steam drum , and - from the media temperature in the steam discharge pipe measured by means of the measuring device and the boiling temperature in the steam drum a temperature difference is determined, the value of which serves to trigger a signal , with which measures to prevent damage to the system are initiated. - a media temperature of the water-steam mixture coming from the evaporator in the steam discharge pipe measured by means of measuring device at, at least, one point before entering the steam drum is measured by means of sensors in immersion sleeves, - a boiling temperature is measured or calculated in the steam drum , and - from the media temperature in the steam discharge pipe measured by means of the measuring device and the boiling temperature in the steam drum a temperature difference is determined, the value of which serves to trigger a signal , with which measures to prevent damage to the system are initiated.
A method of detecting Candida auris (CA) in a sample, the method comprising: - performing an amplifying step comprising contacting the sample with a set of CA 5.8s/ITS2 rRNA gene primers to produce an amplification product if CA 5.8s/ITS2 rRNA nucleic acid is present in the sample; - performing a hybridizing step comprising contacting the amplification product with one or more detectable CA 5.8s/ITS2 rRNA gene probes; and - detecting the presence or absence of the amplification product, wherein the presence of the amplification product is indicative of the presence of CA in the sample and wherein the absence of the amplification product is indicative of the absence of CA in the sample; wherein the set of CA 5.8s/ITS2 rRNA gene primers comprises a first oligonucleotide primer comprising a first nucleic acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 and a second oligonucleotide primer comprising a second nucleic acid sequence of SEQ ID NO: 5; and wherein the one or more detectable CA 5.8s/ITS2 rRNA gene oligonucleotide probe comprises a third nucleic acid sequence of SEQ ID NO: 9 or SEQ ID NO: 10, or the complement thereof; or wherein the set of CA 5.8s/ITS2 rRNA gene primers comprises a first oligonucleotide primer comprising a first nucleic acid sequence of SEQ ID NO: 3 and a second oligonucleotide primer comprising a second nucleic acid sequence of SEQ ID NO: 8; and wherein the one or more detectable CA 5.8s/ITS2 rRNA gene oligonucleotide probe comprises a third nucleic acid sequence of SEQ ID NO: 11, or the complement thereof. - performing an amplifying step comprising contacting the sample with a set of CA 5.8s/ITS2 rRNA gene primers to produce an amplification product if CA 5.8s/ITS2 rRNA nucleic acid is present in the sample; - performing a hybridizing step comprising contacting the amplification product with one or more detectable CA 5.8s/ITS2 rRNA gene probes; and - detecting the presence or absence of the amplification product, wherein the presence of the amplification product is indicative of the presence of CA in the sample and wherein the absence of the amplification product is indicative of the absence of CA in the sample; wherein the set of CA 5.8s/ITS2 rRNA gene primers comprises a first oligonucleotide primer comprising a first nucleic acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 and a second oligonucleotide primer comprising a second nucleic acid sequence of SEQ ID NO: 5; and wherein the one or more detectable CA 5.8s/ITS2 rRNA gene oligonucleotide probe comprises a third nucleic acid sequence of SEQ ID NO: 9 or SEQ ID NO: 10, or the complement thereof; or wherein the set of CA 5.8s/ITS2 rRNA gene primers comprises a first oligonucleotide primer comprising a first nucleic acid sequence of SEQ ID NO: 3 and a second oligonucleotide primer comprising a second nucleic acid sequence of SEQ ID NO: 8; and wherein the one or more detectable CA 5.8s/ITS2 rRNA gene oligonucleotide probe comprises a third nucleic acid sequence of SEQ ID NO: 11, or the complement thereof.
A method of controlling operation of a plurality of movers traveling along an automated independent cart system, the system including a track having a plurality of track segments , each track segment having a respective controller , the method comprising the steps of: receiving, at a first controller of a first track segment , a motion command for a first mover , wherein the first controller is responsible for the first mover over the entire track; receiving, at the first controller, from a second controller of a second track segment anywhere along the track, a position feedback corresponding to a location of the first mover on the second track segment; determining, at the first controller, a force command for the first mover on the second track segment based on the motion command and the position feedback, and sending the determined force command for the first mover to the second controller controlling the second track segment; and generating, at the second controller , an excitation field to interact with a magnet of the first mover based on the received force command. receiving, at a first controller of a first track segment , a motion command for a first mover , wherein the first controller is responsible for the first mover over the entire track; receiving, at the first controller, from a second controller of a second track segment anywhere along the track, a position feedback corresponding to a location of the first mover on the second track segment; determining, at the first controller, a force command for the first mover on the second track segment based on the motion command and the position feedback, and sending the determined force command for the first mover to the second controller controlling the second track segment; and generating, at the second controller , an excitation field to interact with a magnet of the first mover based on the received force command.
A mobile wireless communications device comprising: a wireless transceiver and a controller for cooperating therewith for receiving text messages from a wireless communications network ; and a wireless audio output connected to said controller ; said controller for automatically switching from a text message mode to an audio message mode when a short-range wireless connection is established between said wireless audio output and a wireless headset , and when in the audio message mode, outputting at least one audio message comprising speech generated from at least one of the received text messages via said wireless audio output. a wireless transceiver and a controller for cooperating therewith for receiving text messages from a wireless communications network ; and a wireless audio output connected to said controller ; said controller for automatically switching from a text message mode to an audio message mode when a short-range wireless connection is established between said wireless audio output and a wireless headset , and when in the audio message mode, outputting at least one audio message comprising speech generated from at least one of the received text messages via said wireless audio output.
An electromagnetic dog clutch, comprising a movable gear sleeve and a fixed gear sleeve that mesh with each other for transmission, a first end cap is provided on an outer side of the movable gear sleeve , a bearing is provided on an outer circumference of the movable gear sleeve , the bearing is embedded in an bearing seat , a rear end of the bearing seat is provided with a positioning surface, a front end of the first end cap is a vertical plane that matches the positioning surface of the bearing seat , and characterized in that : the front end of the first end cap is provided with a positioning pin , the rear end of the bearing seat is provided with a positioning hole to cooperate with the positioning pin , and the positioning pin is inserted into the positioning hole to limit the bearing seat and the first end cap so that they can move in an axial direction relative to each other but cannot rotate relative to each other.
A method of producing methanol, the method comprising: combusting feed hydrocarbons with an oxidant that comprises 70 to 99.5 wt. % oxygen to generate heat and produce a heated gas stream at a temperature of 1200 to 1800 °C, wherein the heated gas stream comprises carbon dioxide and water; heating natural gas, with heat from the heated gas stream, to a temperature sufficient to reform the natural gas and produce synthesis gas, wherein the heating of the natural gas concurrently cools the heated gas stream to form a cooled gas stream comprising carbon dioxide and water; and reacting the synthesis gas and at least some of the carbon dioxide from the cooled gas stream under reaction conditions sufficient to produce methanol; wherein reforming the natural gas comprises reacting the natural gas with water. combusting feed hydrocarbons with an oxidant that comprises 70 to 99.5 wt. % oxygen to generate heat and produce a heated gas stream at a temperature of 1200 to 1800 °C, wherein the heated gas stream comprises carbon dioxide and water; heating natural gas, with heat from the heated gas stream, to a temperature sufficient to reform the natural gas and produce synthesis gas, wherein the heating of the natural gas concurrently cools the heated gas stream to form a cooled gas stream comprising carbon dioxide and water; and reacting the synthesis gas and at least some of the carbon dioxide from the cooled gas stream under reaction conditions sufficient to produce methanol; wherein reforming the natural gas comprises reacting the natural gas with water.
A detergent composition comprising: 0.01 to 40 wt-% of a phosphinosuccinic acid derivative, wherein the phosphinosuccinic acid derivative is a combination of phosphonosuccinic acid and mono-, bis- and oligomeric phosphinosuccinic acid adducts; and 1 to 90 wt-% of an alkalinity source selected from the group consisting of an alkali metal hydroxide, carbonate, metasilicate, silicate and mixtures thereof, wherein a use solution of the detergent composition has a pH greater than 9 ; and characterized in that the detergent composition further comprises 0.1 to 40 wt-% of a nonionic surfactant comprising ethylene oxide, propylene oxide, or a combination of ethylene and propylene oxide. 0.01 to 40 wt-% of a phosphinosuccinic acid derivative, wherein the phosphinosuccinic acid derivative is a combination of phosphonosuccinic acid and mono-, bis- and oligomeric phosphinosuccinic acid adducts; and 1 to 90 wt-% of an alkalinity source selected from the group consisting of an alkali metal hydroxide, carbonate, metasilicate, silicate and mixtures thereof, wherein a use solution of the detergent composition has a pH greater than 9 ; and characterized in that the detergent composition further comprises 0.1 to 40 wt-% of a nonionic surfactant comprising ethylene oxide, propylene oxide, or a combination of ethylene and propylene oxide.
A can combustor for a gas turbine , the can combustor comprising: - at least a burner ; - at least a liner downstream the burner and defining an inner combustion chamber ; - a damper comprising a damper body defining a damping volume wrapped outside around the liner and in fluid connection with the combustion chamber ; the damper body being spaced from the liner in order to form a cooling gap between the damper body and the liner and limited by an inner surface of the damper body facing an outer surface of the liner , being present at least a damper neck acting as a bridge in the cooling gap between the liner and the damper body for fluidly connecting the damping volume with the combustion chamber ; characterized in that the cooling gap between the damper body and the liner is provided with a cooling device configured for increasing the heat transfer between the cooling air passing in the gap and the liner and the damper body , the cooling device being arranged on the outer surface of the liner and on the inner surface of the damper body . - at least a burner ; - at least a liner downstream the burner and defining an inner combustion chamber ; - a damper comprising a damper body defining a damping volume wrapped outside around the liner and in fluid connection with the combustion chamber ; the damper body being spaced from the liner in order to form a cooling gap between the damper body and the liner and limited by an inner surface of the damper body facing an outer surface of the liner , being present at least a damper neck acting as a bridge in the cooling gap between the liner and the damper body for fluidly connecting the damping volume with the combustion chamber ; characterized in that the cooling gap between the damper body and the liner is provided with a cooling device configured for increasing the heat transfer between the cooling air passing in the gap and the liner and the damper body , the cooling device being arranged on the outer surface of the liner and on the inner surface of the damper body .
A process for synthesizing liraglutide with a low racemate impurity comprising: synthesizing to obtain a propeptide, and then coupling a 2~5 amino acid residue-containing peptide with Thr-Phe to the propeptide by using solid-phase synthesis, further performing a solid-phase synthesis to obtain a liraglutide resin, cleaving the liraglutide resin after side chain modification, or directly cleaving the liraglutide resin, purifying, and lyophilizing to give liraglutide, wherein the propeptide is Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-ε-(N-α-Palmitoyl-L-γ-glutamyl))-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly, wherein the 2~5 amino acid residue-containing peptide with Thr-Phe is Thr-Phe-Thr. synthesizing to obtain a propeptide, and then coupling a 2~5 amino acid residue-containing peptide with Thr-Phe to the propeptide by using solid-phase synthesis, further performing a solid-phase synthesis to obtain a liraglutide resin, cleaving the liraglutide resin after side chain modification, or directly cleaving the liraglutide resin, purifying, and lyophilizing to give liraglutide, wherein the propeptide is Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(N-ε-(N-α-Palmitoyl-L-γ-glutamyl))-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly, wherein the 2~5 amino acid residue-containing peptide with Thr-Phe is Thr-Phe-Thr.