An intravenous (IV) system, comprising: an IV catheter , configured to be inserted into a vein of a living subject; a fluid controlling device in fluid communication with the IV catheter, configured to control fluid flow from a fluid source to the IV catheter; at least one pressure sensor in fluid communication with the IV catheter, configured to acquire, from the vein of the living subject, peripheral venous signals; and a processing device communicatively connected to the at least one pressure sensor, configured to: receive the peripheral venous signals from the at least one pressure sensor; perform a spectral analysis on the peripheral venous signals to obtain a peripheral venous pressure frequency spectrum; perform a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine an IV line functionality of the IV catheter in real time, wherein the IV line functionality of the IV catheter indicates IV infiltration when amplitude decreases greater than a first threshold are detected from the peaks of the peripheral venous pressure frequency spectrum; and when the IV line functionality of the IV catheter indicates IV infiltration, control the fluid controlling device to stop the fluid flow from the fluid source to the IV catheter. an IV catheter , configured to be inserted into a vein of a living subject; a fluid controlling device in fluid communication with the IV catheter, configured to control fluid flow from a fluid source to the IV catheter; at least one pressure sensor in fluid communication with the IV catheter, configured to acquire, from the vein of the living subject, peripheral venous signals; and a processing device communicatively connected to the at least one pressure sensor, configured to: receive the peripheral venous signals from the at least one pressure sensor; perform a spectral analysis on the peripheral venous signals to obtain a peripheral venous pressure frequency spectrum; perform a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine an IV line functionality of the IV catheter in real time, wherein the IV line functionality of the IV catheter indicates IV infiltration when amplitude decreases greater than a first threshold are detected from the peaks of the peripheral venous pressure frequency spectrum; and when the IV line functionality of the IV catheter indicates IV infiltration, control the fluid controlling device to stop the fluid flow from the fluid source to the IV catheter. receive the peripheral venous signals from the at least one pressure sensor; perform a spectral analysis on the peripheral venous signals to obtain a peripheral venous pressure frequency spectrum; perform a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine an IV line functionality of the IV catheter in real time, wherein the IV line functionality of the IV catheter indicates IV infiltration when amplitude decreases greater than a first threshold are detected from the peaks of the peripheral venous pressure frequency spectrum; and when the IV line functionality of the IV catheter indicates IV infiltration, control the fluid controlling device to stop the fluid flow from the fluid source to the IV catheter. <EOS>