A flow cell system , comprising: a socket comprising a base portion , a plurality of electrical contacts , and a cover portion coupled with the base portion comprising at least one first port , wherein the base portion and the cover portion cooperatively form an enclosure , wherein the electrical contacts extend between the enclosure and an exterior side of the base portion , and the at least one first port extends between the enclosure and an exterior side of the cover portion ; and a flow cell device secured within the enclosure of the socket , comprising: a frameless light detection device comprising a base wafer portion , a plurality of dielectric layers extending over the base wafer portion , a reaction structure extending over the dielectric layers that comprises a detector surface , a plurality of light sensors , device circuitry extending through the dielectric layers electrically coupled to the light sensors to transmit data signals based on photons detected by the light sensors , and a plurality of light guides associated with the light sensors ; and a lid extending over the detector surface with a flow channel therebetween, the lid comprising at least one second port in communication with the flow channel and the at least one first port of the socket , wherein the device circuity of the light detection device of the flow cell device is electrically coupled to the electrical contacts of the socket . a socket comprising a base portion , a plurality of electrical contacts , and a cover portion coupled with the base portion comprising at least one first port , wherein the base portion and the cover portion cooperatively form an enclosure , wherein the electrical contacts extend between the enclosure and an exterior side of the base portion , and the at least one first port extends between the enclosure and an exterior side of the cover portion ; and a flow cell device secured within the enclosure of the socket , comprising: a frameless light detection device comprising a base wafer portion , a plurality of dielectric layers extending over the base wafer portion , a reaction structure extending over the dielectric layers that comprises a detector surface , a plurality of light sensors , device circuitry extending through the dielectric layers electrically coupled to the light sensors to transmit data signals based on photons detected by the light sensors , and a plurality of light guides associated with the light sensors ; and a lid extending over the detector surface with a flow channel therebetween, the lid comprising at least one second port in communication with the flow channel and the at least one first port of the socket , wherein the device circuity of the light detection device of the flow cell device is electrically coupled to the electrical contacts of the socket . a frameless light detection device comprising a base wafer portion , a plurality of dielectric layers extending over the base wafer portion , a reaction structure extending over the dielectric layers that comprises a detector surface , a plurality of light sensors , device circuitry extending through the dielectric layers electrically coupled to the light sensors to transmit data signals based on photons detected by the light sensors , and a plurality of light guides associated with the light sensors ; and a lid extending over the detector surface with a flow channel therebetween, the lid comprising at least one second port in communication with the flow channel and the at least one first port of the socket , wherein the device circuity of the light detection device of the flow cell device is electrically coupled to the electrical contacts of the socket . <EOS>