A compound of Formula I: wherein: R 1 is -COOH or -C(O)OR a , wherein R a is optionally substituted C 1-6 alkyl; wherein said optional alkyl substituent is selected from OH, halogen, -OC 1-8 alkyl and -(O(CH 2 ) 1-8 ) q -OC 1-8 alkyl; and q is 1, 2, 3, 4, 5 or 6; R 2 is optionally substituted C 1-6 alkyl, wherein said optional alkyl substituent is selected from -OH, -SH, -OC 1-6 alkyl, -SC 1-6 alkyl, -COOH, -C(O)OC 1-6 alkyl, -C(O)NH 2 , C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, and heterocycle; R 3 is H or unsubstituted C 1-6 alkyl; R 4 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -NR 11 R 12 , -S(O) m R 9 , -C(O)R 10 , -C(O)OC 1-6 alkyl, -C(O)SC 1-6 alkyl, -OR 13 or -SR 13 ; R 5 is H, C 1-6 alkyl, C 1-6 haloalkyl, halogen, -S(O) m R 9 or -C(O)R 10 ; R 6 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -S(O) m R 9 , -C(O)R 10 or -OR 11 ; R 7 is H, C 1-6 alkyl, C 1-6 haloalkyl, halogen, -S(O) m R 9 or -C(O)R 10 ; R 8 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -NR 11 R 12 , -S(O) m R 9 , -C(O)R 10 , -C(O)OC 1-6 alkyl, -C(O)SC 1-6 alkyl, -OR 13 or -SR 13 ; each R 9 is independently -OH, C 1-6 alkyl or C 6-10 aryl; each R 10 is independently -OH, C 1-6 alkyl or C 6-10 aryl; each R 11 is independently H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl or heterocycle; each R 12 is independently H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl or heterocycle; each R 13 is independently H or C 1-8 alkyl; each m is independently 1 or 2; and n is 1, 2 or 3; or a single enantiomer thereof; or a mixture of enantiomers thereof; or a tautomer of the foregoing; or pharmaceutically acceptable salt of the foregoing; provided that the compound is not: R 1 is -COOH or -C(O)OR a , wherein R a is optionally substituted C 1-6 alkyl; wherein said optional alkyl substituent is selected from OH, halogen, -OC 1-8 alkyl and -(O(CH 2 ) 1-8 ) q -OC 1-8 alkyl; and q is 1, 2, 3, 4, 5 or 6; R 2 is optionally substituted C 1-6 alkyl, wherein said optional alkyl substituent is selected from -OH, -SH, -OC 1-6 alkyl, -SC 1-6 alkyl, -COOH, -C(O)OC 1-6 alkyl, -C(O)NH 2 , C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, and heterocycle; R 3 is H or unsubstituted C 1-6 alkyl; R 4 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -NR 11 R 12 , -S(O) m R 9 , -C(O)R 10 , -C(O)OC 1-6 alkyl, -C(O)SC 1-6 alkyl, -OR 13 or -SR 13 ; R 5 is H, C 1-6 alkyl, C 1-6 haloalkyl, halogen, -S(O) m R 9 or -C(O)R 10 ; R 6 is C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -S(O) m R 9 , -C(O)R 10 or -OR 11 ; R 7 is H, C 1-6 alkyl, C 1-6 haloalkyl, halogen, -S(O) m R 9 or -C(O)R 10 ; R 8 is H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl, heterocycle, halogen, -NR 11 R 12 , -S(O) m R 9 , -C(O)R 10 , -C(O)OC 1-6 alkyl, -C(O)SC 1-6 alkyl, -OR 13 or -SR 13 ; each R 9 is independently -OH, C 1-6 alkyl or C 6-10 aryl; each R 10 is independently -OH, C 1-6 alkyl or C 6-10 aryl; each R 11 is independently H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl or heterocycle; each R 12 is independently H, C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 6-10 aryl or heterocycle; each R 13 is independently H or C 1-8 alkyl; each m is independently 1 or 2; and n is 1, 2 or 3; or a single enantiomer thereof; or a mixture of enantiomers thereof; or a tautomer of the foregoing; or pharmaceutically acceptable salt of the foregoing; provided that the compound is not: <EOS>