mhurhangee/patent-ind-claim-en huggingface dataset:
An in vitro method for determining the efficacy of a composition used to treat articular joint conditions in mammals, wherein the method comprises: i. measuring the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) cartilage degradation biomarker in said mammal from before exercise and after exercise, wherein the exercise is performed for a brief period per day for a duration of from 24 hours to 4 weeks; and wherein the exercise is of low impact to the articular joint and of moderate intensity; ii. after a composition used to treat articular joint conditions has been administered to said mammal, subsequently measuring the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) cartilage degradation biomarker in said mammal from before exercise and after exercise, wherein a decrease in the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) after exercise in step (ii) as compared to the change in levels of said c-terminal cross-linked telopeptide of type-II collagen (CTX-II) after exercise in step (i) indicates that said composition is effective to treat articular joint conditions in said mammal. i. measuring the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) cartilage degradation biomarker in said mammal from before exercise and after exercise, wherein the exercise is performed for a brief period per day for a duration of from 24 hours to 4 weeks; and wherein the exercise is of low impact to the articular joint and of moderate intensity; ii. after a composition used to treat articular joint conditions has been administered to said mammal, subsequently measuring the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) cartilage degradation biomarker in said mammal from before exercise and after exercise, wherein a decrease in the change in levels of c-terminal cross-linked telopeptide of type-II collagen (CTX-II) after exercise in step (ii) as compared to the change in levels of said c-terminal cross-linked telopeptide of type-II collagen (CTX-II) after exercise in step (i) indicates that said composition is effective to treat articular joint conditions in said mammal.
Device for transporting textile articles, preferably items of clothing, hanging on carriers , having a conveying path which has at least one support section on which the carriers are able to be moved along the conveying path in a transport direction , and at least one conveying section which is able to be driven in a transport direction , and having entrainment elements which are disposed so as to be spaced apart on the conveying section and are mounted on at least one support pin connected to the conveying section , characterized in that each entrainment element is able to be fastened in a latching manner to at least one support pin , wherein the latching connection between the entrainment elements and the conveying section is established by attaching each entrainment element to at least one support pin on the conveying section in the direction transverse to the longitudinal centre axis of the at least one support pin .
High-side switch for supplying current to at least one sensor, comprising: - two connections ; - a current path , via which the connections are electrically conductively connected to one another, and within which a measuring transistor and at least two resistors are connected in series with one another, wherein the high-side switch also comprises: - a power transistor that is connected in parallel with the current path , - a comparator having: two inputs , of which one is fixedly connected to the current path and one can be variably connected to the current path in such a way that the number of resistors located between the connecting points of the inputs to the current path can be changed, one output that is electrically conductively connected to the control input of the measuring transistor and of the power transistor , wherein a first calibratable current source is electrically conductively connected to the control input of the measuring transistor , characterized in that the first calibratable current source is designed to compensate for an error voltage, resulting on account of the negative feedback of the resistors at the control input of the power transistor , by switching a first compensation current (Ik1) to the control input of the measuring transistor . - two connections ; - a current path , via which the connections are electrically conductively connected to one another, and within which a measuring transistor and at least two resistors are connected in series with one another, - a power transistor that is connected in parallel with the current path , - a comparator having: two inputs , of which one is fixedly connected to the current path and one can be variably connected to the current path in such a way that the number of resistors located between the connecting points of the inputs to the current path can be changed, one output that is electrically conductively connected to the control input of the measuring transistor and of the power transistor , wherein a first calibratable current source is electrically conductively connected to the control input of the measuring transistor , characterized in that the first calibratable current source is designed to compensate for an error voltage, resulting on account of the negative feedback of the resistors at the control input of the power transistor , by switching a first compensation current (Ik1) to the control input of the measuring transistor .
A compound of Formula I: wherein: R 1 is C 6 -C 14 aryl, 5- to 10-membered heteroaryl, C 3 -C 6 cycloalkyl, or 4- to 10-membered heterocycloalkyl, wherein the C 6 -C 14 aryl, 5- to 10-membered heteroaryl, C 3 -C 6 cycloalkyl, or 4- to 10-membered heterocycloalkyl of R 1 are each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, -CN, -NO 2 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, -OR a , -SR a , -S(O) 2 R a , -NR b R c , -C(O)R a , -OC(O)R a , -C(O)OR a , -C(O)NR b R c , -OC(O)NR b R c , -NR a C(O)R b , -NR a C(O)OR b , substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted C 3 -C 6 cycloalkenyl, substituted or unsubstituted C 6 -C 14 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 4- to 10-membered heterocycloalkyl; L is -S(O) 2 -, -O-, -C(O)- or -CH 2 -; Y 1 is CH or N; R 2 is: G 1 is S or N; G 2 is CR 3 , S, or N; R 3 is H, C 1-6 alkyl or C 1-6 haloalkyl; and R a , R b , R c , R e , and R f are each independently H or C 1-4 alkyl; wherein when L is -S(O) 2 - and Y 1 is N, R 1 is not 4,4-difluoro-piperidin1-yl; or a pharmaceutically acceptable salt thereof. R 1 is C 6 -C 14 aryl, 5- to 10-membered heteroaryl, C 3 -C 6 cycloalkyl, or 4- to 10-membered heterocycloalkyl, wherein the C 6 -C 14 aryl, 5- to 10-membered heteroaryl, C 3 -C 6 cycloalkyl, or 4- to 10-membered heterocycloalkyl of R 1 are each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, -CN, -NO 2 , substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, -OR a , -SR a , -S(O) 2 R a , -NR b R c , -C(O)R a , -OC(O)R a , -C(O)OR a , -C(O)NR b R c , -OC(O)NR b R c , -NR a C(O)R b , -NR a C(O)OR b , substituted or unsubstituted C 3 -C 6 cycloalkyl, substituted or unsubstituted C 3 -C 6 cycloalkenyl, substituted or unsubstituted C 6 -C 14 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, and substituted or unsubstituted 4- to 10-membered heterocycloalkyl; L is -S(O) 2 -, -O-, -C(O)- or -CH 2 -; Y 1 is CH or N; R 2 is: G 1 is S or N; G 2 is CR 3 , S, or N; R 3 is H, C 1-6 alkyl or C 1-6 haloalkyl; and R a , R b , R c , R e , and R f are each independently H or C 1-4 alkyl; wherein when L is -S(O) 2 - and Y 1 is N, R 1 is not 4,4-difluoro-piperidin1-yl; or a pharmaceutically acceptable salt thereof.
A neural network control system comprising: a trace generator coupled to a Sanger Sequencer and generating a trace for a biological sample; a segmenter to divide the trace into scan windows; an aligner to shift the scan windows; logic to determine associated annotated basecalls for each of the scan windows to generate target annotated basecalls for use in training; a bi-directional recurrent neural network, BRNN, comprising: at least one long short term memory, LSTM, or general recurrent unit, GRU, layer; an output layer configured to output scan label probabilities for all scans in a scan window; a Connectionist Temporal Classification loss function to calculate the loss between the output scan label probabilities and the target annotated basecalls; and a gradient descent optimizer configured as a closed loop feedback control to the BRNN to update weights of the BRNN to minimize the loss against a minibatch of training samples randomly selected from the target annotated basecalls at each training step. a trace generator coupled to a Sanger Sequencer and generating a trace for a biological sample; a segmenter to divide the trace into scan windows; an aligner to shift the scan windows; logic to determine associated annotated basecalls for each of the scan windows to generate target annotated basecalls for use in training; a bi-directional recurrent neural network, BRNN, comprising: at least one long short term memory, LSTM, or general recurrent unit, GRU, layer; an output layer configured to output scan label probabilities for all scans in a scan window; a Connectionist Temporal Classification loss function to calculate the loss between the output scan label probabilities and the target annotated basecalls; and a gradient descent optimizer configured as a closed loop feedback control to the BRNN to update weights of the BRNN to minimize the loss against a minibatch of training samples randomly selected from the target annotated basecalls at each training step. at least one long short term memory, LSTM, or general recurrent unit, GRU, layer; an output layer configured to output scan label probabilities for all scans in a scan window; a Connectionist Temporal Classification loss function to calculate the loss between the output scan label probabilities and the target annotated basecalls; and a gradient descent optimizer configured as a closed loop feedback control to the BRNN to update weights of the BRNN to minimize the loss against a minibatch of training samples randomly selected from the target annotated basecalls at each training step.
A pharmaceutical composition, comprising: 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof; and hydroxypropyl-β-cyclodextrin. 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide or a pharmaceutically acceptable salt thereof; and hydroxypropyl-β-cyclodextrin.
An acoustic device capable of producing active noise reduction, which may be positioned on the head of a user, comprising at least one microphone able to sense a representative sound signal of ambient noise, including at least one acoustic module for active noise reduction comprising an osteophonic transducer , capable of being positioned on a side flank of the head of the user, and of transmitting a vibratory signal transformed by bone conduction into an acoustic signal which may be perceived by the user, connected to said microphone, said at least one acoustic module including an electronic circuit capable of generating a vibratory signal giving the possibility of attenuating the perception of said ambient noise by the user, the acoustic device being characterized in that said electronic circuit implements a filter defined by a transfer function (H FO ) for noise reduction, said transfer function (H FO ) being determined in order to produce noise attenuation according to direct bone conduction between the osteophonic transducer and the inner ear of a user located on the same side as said transducer , said noise reduction transfer function (H FO ) depending on a ratio of a direct bone conduction transfer function (H CO ) representative of said bone conduction and of an airborne conduction transfer function (H CA ) representative of the conduction of an airborne acoustic signal between an outer ear and an inner ear located on a same side, and in that said transfer function is defined by the formula: H FO = − R ⋅ H b G H m . H TO wherein R is said ratio of a direct bone conduction transfer function (H CO ) and of the airborne conduction transfer function (H CA ), H b G is a characteristic transfer function of ambient noise, H m is the transfer function of said microphone and H TO is the transfer function of said osteophonic transducer .
A method, performed by a mobile device , for managing a sequence of access control keys for use by the mobile device , comprising: receiving a plurality of access control keys and storing the plurality of access control keys at the mobile device ; receiving, at the mobile device, sequence data associated with the plurality of access control keys ; retrieving one or more of the stored plurality of access control keys in an order indicated by the sequence data; determining whether the one or more retrieved access control keys are valid, wherein the one or more retrieved access control keys are determined to be valid based on successful use of a previous one of the plurality of access control keys designated by the sequence data and presented to a first access control reader; and presenting a valid access control key to a second access control reader . receiving a plurality of access control keys and storing the plurality of access control keys at the mobile device ; receiving, at the mobile device, sequence data associated with the plurality of access control keys ; retrieving one or more of the stored plurality of access control keys in an order indicated by the sequence data; determining whether the one or more retrieved access control keys are valid, wherein the one or more retrieved access control keys are determined to be valid based on successful use of a previous one of the plurality of access control keys designated by the sequence data and presented to a first access control reader; and presenting a valid access control key to a second access control reader .
Ply extending along a main direction (P'), comprising: - a polymer matrix , - metallic monofilaments embedded in the polymer matrix , the metallic monofilaments being substantially parallel relative to one another and to the main direction (P') of the ply , each metallic monofilament having a main axis (G) and a torsional elastic deformation about its main axis (G), the ply comprising first and second groups of metallic monofilaments , each metallic monofilament of the first group having a torsional elastic deformation in a first direction about its main axis (G), each metallic monofilament (46") of the second group having a torsional elastic deformation in a second direction about its main axis (G), the first direction being opposite to the second direction, and it being understood that the torsional elastic deformation is positive in the first direction and negative in the second direction, the metallic monofilaments being such that: ∘ the absolute value of the torsional elastic deformation C of each metallic monofilament is such that |C| ≤ 6 turns per ten metres of metallic monofilament , and ∘ the mean S of the torsional elastic deformations of the metallic monofilaments of the ply is such that -0.25 turn per ten metres of metallic monofilaments ≤ S ≤ +0.25 turn per ten metres of metallic monofilaments, the metallic monofilaments being arranged next to one another so as to alternate one or more metallic monofilaments of the first group with one or more metallic monofilaments (46") of the second group. - a polymer matrix , - metallic monofilaments embedded in the polymer matrix , the metallic monofilaments being substantially parallel relative to one another and to the main direction (P') of the ply , each metallic monofilament having a main axis (G) and a torsional elastic deformation about its main axis (G), ∘ the absolute value of the torsional elastic deformation C of each metallic monofilament is such that |C| ≤ 6 turns per ten metres of metallic monofilament , and ∘ the mean S of the torsional elastic deformations of the metallic monofilaments of the ply is such that -0.25 turn per ten metres of metallic monofilaments ≤ S ≤ +0.25 turn per ten metres of metallic monofilaments,
An absorbent article comprising: one or more discrete front panels ; a discrete back panel ; and an absorbent insert joined to the front and back panels , wherein said front and back panels are separated from each other along a longitudinal axis y-y running parallel to a length of said insert and crossing both said front and back panels , and wherein said insert is interposed between said front panel and said back panel such to form a substantially H-shaped absorbent article, wherein the front and back panels have a total width W being greater than a width w of said insert along a transverse axis x-x, and wherein said insert comprises a liquid permeable topsheet , a liquid impermeable backsheet , and an absorbent material sandwiched between said topsheet and backsheet , characterized in that the back panel consists of a unitary panel and in that the front and/or back panels comprise one or more fasteners such that the front panel and back panel can be refastenably coupled together to a closed position onto a wearer, and wherein only one of the front panel and the back panel is elastic, and wherein the unitary back panel has a substantially trapezoidal shape. one or more discrete front panels ; a discrete back panel ; and an absorbent insert joined to the front and back panels , wherein said front and back panels are separated from each other along a longitudinal axis y-y running parallel to a length of said insert and crossing both said front and back panels , and wherein said insert is interposed between said front panel and said back panel such to form a substantially H-shaped absorbent article, wherein the front and back panels have a total width W being greater than a width w of said insert along a transverse axis x-x, and wherein said insert comprises a liquid permeable topsheet , a liquid impermeable backsheet , and an absorbent material sandwiched between said topsheet and backsheet , characterized in that the back panel consists of a unitary panel and in that the front and/or back panels comprise one or more fasteners such that the front panel and back panel can be refastenably coupled together to a closed position onto a wearer, and wherein only one of the front panel and the back panel is elastic, and wherein the unitary back panel has a substantially trapezoidal shape.
Sanitary functional unit which has a housing which can be fastened releasably to the water outlet of a sanitary outlet fitting, wherein the housing has an outflow-side housing end surface with outflow openings , which outflow-side housing end surface forms a flow straightener and has a slot whose oppositely situated slot longitudinal sides are configured as turning engagement surfaces or tool engagement surfaces for a turning tool which can be inserted releasably into the at least one slot, wherein the outflow openings are surrounded by walls configured as flow-guiding walls, which have a greater height in comparison with the clear diameter of the outflow openings , wherein the outflow-side housing end surface has a cross-sectional thickening at least in the region of the at least one slot , wherein the hole structure provided on the housing end surface outside the at least one slot is spaced apart from the at least one slot in such a way that the slot longitudinal sides have a greater wall thickness in comparison with the flow-guiding walls , wherein the housing can be fastened releasably to the water outlet of the outlet fitting by means of a screw connection or bayonet connection provided between housing outer periphery and fitting inner periphery, and wherein the turning tool which can be inserted into the slot can be used for turning the screw connection or bayonet connection provided between housing outer periphery and fitting inner periphery.
A sensor system for a wind turbine , comprising: a blade load sensor ; a blade temperature sensor configured to provide a temperature measurement of an associated blade; and a load calculation module configured to output a temperature-corrected blade load value; characterised by : a processing unit interfaced with the temperature sensor and including: a temperature estimator configured to determine an estimated temperature of the wind turbine blade based on at least one wind turbine parameter; and a comparator configured to generate a fault signal based on a comparison between the blade temperature measurement and the estimated blade temperature, wherein the temperature estimator performs a modelling of the temperature of the blade in the vicinity of the temperature sensor based on the net heat energy transferred to the interior of the blade. a blade load sensor ; a blade temperature sensor configured to provide a temperature measurement of an associated blade; and a load calculation module configured to output a temperature-corrected blade load value; characterised by : a processing unit interfaced with the temperature sensor and including: a temperature estimator configured to determine an estimated temperature of the wind turbine blade based on at least one wind turbine parameter; and a comparator configured to generate a fault signal based on a comparison between the blade temperature measurement and the estimated blade temperature, wherein the temperature estimator performs a modelling of the temperature of the blade in the vicinity of the temperature sensor based on the net heat energy transferred to the interior of the blade. a temperature estimator configured to determine an estimated temperature of the wind turbine blade based on at least one wind turbine parameter; and a comparator configured to generate a fault signal based on a comparison between the blade temperature measurement and the estimated blade temperature, wherein the temperature estimator performs a modelling of the temperature of the blade in the vicinity of the temperature sensor based on the net heat energy transferred to the interior of the blade.