A chromatography cartridge comprising: a barrel arranged to be at least at one end sealed with a cap and a seal member , wherein: - the barrel comprises a thread arranged on the outer cylindrical surface of the barrel , a barrel seal surface extending radially on the end surface of the barrel and a circumferential barrel lip provided on the barrel seal surface and extending in the longitudinal direction; - the cap comprises an outer cylindrical part which on its inner surface comprises a thread arranged to mate with the thread of the barrel , a radially extending top , an intermediate part joining the outer cylindrical part with the radially extending top and an inner cylindrical part , a seal holder provided between the outer surface of the inner cylindrical part and an inner surface of the intermediate part , a cap seal surface arranged between the seal holder and the inner surface of the intermediate part ; and - the seal member is provided in a space formed by the seal holder , the inner surface of the intermediate part and the cap seal surface ; and wherein: the intermediate part of the cap on its inner surface comprises a contact surface , and the cap being mounted on the barrel , the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member , the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder , the cap seal surface and the inside of the barrel lip , forming a second cartridge seal. - the barrel comprises a thread arranged on the outer cylindrical surface of the barrel , a barrel seal surface extending radially on the end surface of the barrel and a circumferential barrel lip provided on the barrel seal surface and extending in the longitudinal direction; - the cap comprises an outer cylindrical part which on its inner surface comprises a thread arranged to mate with the thread of the barrel , a radially extending top , an intermediate part joining the outer cylindrical part with the radially extending top and an inner cylindrical part , a seal holder provided between the outer surface of the inner cylindrical part and an inner surface of the intermediate part , a cap seal surface arranged between the seal holder and the inner surface of the intermediate part ; and - the seal member is provided in a space formed by the seal holder , the inner surface of the intermediate part and the cap seal surface ; and wherein: the intermediate part of the cap on its inner surface comprises a contact surface , and the cap being mounted on the barrel , the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member , the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder , the cap seal surface and the inside of the barrel lip , forming a second cartridge seal. the intermediate part of the cap on its inner surface comprises a contact surface , and the cap being mounted on the barrel , the contact surface is arranged to be in contact with, and exerts a force on, the outer surface of the barrel lip which is sheared towards the centre of the cartridge and which barrel lip in turn exerts a force on the seal member , the contact surface and the barrel lip forming a first cartridge seal; and the seal member is arranged to be in contact with at least the outside of the seal holder , the cap seal surface and the inside of the barrel lip , forming a second cartridge seal. <EOS>