mhurhangee/patent-ind-claim-en huggingface dataset:
A PD-1 antagonist, an ATR inhibitor and a platinating agent for use in a method for treating a cancer, wherein the PD-1 antagonist is an anti-PD-1 or anti-PD-L1 antibody, or an antigen-binding fragment of the anti-PD-1 or anti-PD-L1 antibody, wherein the platinating agent is selected from the group consisting of cisplatin, carboplatin and oxaliplatin, and wherein the ATR inhibitor is selected from the group consisting of 3-[3-(4-Methylaminomethyl-phenyl)-isoxazol-5-yl]-5-[4-(propane-2-sulfonyl)-phenyl]-pyrazin-2-ylamine, or a pharmaceutically acceptable salt thereof, 2-amino-6-fluoro-N-(5-fluoro-4-{4-[4-(oxetan-3-yl)piperazine-1-carbonyl]piperidin-1-yl}pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, 2-Amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, 4-{4-[ -3-methylmorpholin-4-yl]-6-[1-(S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine, or a pharmaceutically acceptable salt thereof, and 2-[ -3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine, or a pharmaceutically acceptable salt thereof. wherein the PD-1 antagonist is an anti-PD-1 or anti-PD-L1 antibody, or an antigen-binding fragment of the anti-PD-1 or anti-PD-L1 antibody, wherein the platinating agent is selected from the group consisting of cisplatin, carboplatin and oxaliplatin, and wherein the ATR inhibitor is selected from the group consisting of 3-[3-(4-Methylaminomethyl-phenyl)-isoxazol-5-yl]-5-[4-(propane-2-sulfonyl)-phenyl]-pyrazin-2-ylamine, or a pharmaceutically acceptable salt thereof, 2-amino-6-fluoro-N-(5-fluoro-4-{4-[4-(oxetan-3-yl)piperazine-1-carbonyl]piperidin-1-yl}pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, 2-Amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a pharmaceutically acceptable salt thereof, 4-{4-[ -3-methylmorpholin-4-yl]-6-[1-(S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine, or a pharmaceutically acceptable salt thereof, and 2-[ -3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine, or a pharmaceutically acceptable salt thereof.
A computer system, comprising: one or more processors; and memory having collectively stored therein instructions that, when executed by the computer system, cause the computer system to: receive a request to launch a virtual machine that is based on a machine image digitally signed with a key of a vendor; and launch the virtual machine after a determination that one or more policies authorize launching virtual machines that are based on machine images digitally signed by the vendor. one or more processors; and memory having collectively stored therein instructions that, when executed by the computer system, cause the computer system to: receive a request to launch a virtual machine that is based on a machine image digitally signed with a key of a vendor; and launch the virtual machine after a determination that one or more policies authorize launching virtual machines that are based on machine images digitally signed by the vendor. receive a request to launch a virtual machine that is based on a machine image digitally signed with a key of a vendor; and launch the virtual machine after a determination that one or more policies authorize launching virtual machines that are based on machine images digitally signed by the vendor.
A cooling material adapted for use with bodywear, comprising: a base fabric having a high wicking rate of greater than 7.6 cm (3 inches) in 10 minutes as defined by a Vertical Wick Test (AATCC 197) and having a performance characteristic; and one or more discontinuous highly absorbent polymer elements which absorb at least 3% moisture by weight at 30°C and 80% humidity, coupled to a body-facing side of the base fabric, wherein the highly absorbent polymer elements have an enthalpy of less than 10 J·g -1 as measured by DSC upon absorbing water or other fluids, wherein the highly absorbent polymer elements are at least two times as absorbent as the base fabric, and wherein the placement and spacing of the one or more highly absorbent polymer elements leaves a portion of the base fabric uncovered by the highly absorbent polymer elements and enables the base material to retain at least partial performance of the performance characteristic.
A device for pressing a substance out of a deformable tube , the device having the following: - a housing comprising a base end , - an upper portion opposite the base end and - side wall portions between the base end and the upper portion , - a squeezer which can be inserted into the housing , the squeezer having a support element and two opposing jaws for gripping and pressing a substance out of the tube , the housing having, in the upper portion , an opening through which a dispensing outlet of the tube can be guided, and, in opposite parts of the side wall portions , openings by means of which the jaws can be operated, the jaws being fastened at one end to the support element and the squeezer additionally having a manual lever element on at least one jaw , the lever element being connected in a connection region to the jaw in an arrangement in which pressure manually applied to the lever element produces a force on the jaw toward the other jaw , characterized in that the lever element has a body comprising reinforcing ribs , the reinforcing ribs being surrounded, at least in part, by a closed outer shell , a region of the outer shell forming a grip region , the connection region between the lever element and the jaw having a maximum width v which is at most half a width b of the jaw in this region. - a housing comprising a base end , - an upper portion opposite the base end and - side wall portions between the base end and the upper portion , - a squeezer which can be inserted into the housing , the squeezer having a support element and two opposing jaws for gripping and pressing a substance out of the tube ,
Laminated multi-phase busbar for conducting electric energy, comprising a base layer of an electrically insulating material, a first conducting layer of an electrically conducting material which is arranged on and mechanically connected to said base layer , a first intermediate insulating layer of an electrically insulating material which is arranged on and mechanically connected to said first conducting layer , a second conducting layer of an electrically conducting material which is arranged on and mechanically connected to said first intermediate layer and a cover layer of an electrically insulating material which is arranged on said second conducting layer , wherein said electrically insulating material of said base layer , said first intermediate insulating layer and said cover layer is a sheet molding compound including a thermosetting resin and reinforcing fibers, and that the material of said first conducting layer and said second conducting layer is a sheet metal which is mechanically connected to the first intermediate insulating layer by said thermally cured thermosetting resin, wherein said first conducting layer comprises at least one first through-hole which is filled with thermosetting resin and reinforcing fibers, said thermosetting resin and reinforcing fibers in said first through-hole forming a material bridge bonding said base layer to said first intermediate insulating layer . a first conducting layer of an electrically conducting material which is arranged on and mechanically connected to said base layer , a first intermediate insulating layer of an electrically insulating material which is arranged on and mechanically connected to said first conducting layer , a second conducting layer of an electrically conducting material which is arranged on and mechanically connected to said first intermediate layer and a cover layer of an electrically insulating material which is arranged on said second conducting layer , wherein said electrically insulating material of said base layer , said first intermediate insulating layer and said cover layer is a sheet molding compound including a thermosetting resin and reinforcing fibers, and that the material of said first conducting layer and said second conducting layer is a sheet metal which is mechanically connected to the first intermediate insulating layer by said thermally cured thermosetting resin, wherein said first conducting layer comprises at least one first through-hole which is filled with thermosetting resin and reinforcing fibers, said thermosetting resin and reinforcing fibers in said first through-hole forming a material bridge bonding said base layer to said first intermediate insulating layer .
A method for manufacturing doped adhesive tape comprising: producing a paper slurry for manufacturing adhesive tape ; forming a continuous paper sheet using the paper slurry; applying an adhesive sizing to the continuous paper sheet; applying a dopant facilitating the detection of the doped adhesive tape by backscatter x-ray inspection, wherein the dopant comprises iodine, wherein the dopant applied is added to the paper slurry or to the adhesive sizing; and forming a roll of adhesive tape with the adhesive applied thereto. producing a paper slurry for manufacturing adhesive tape ; forming a continuous paper sheet using the paper slurry; applying an adhesive sizing to the continuous paper sheet; applying a dopant facilitating the detection of the doped adhesive tape by backscatter x-ray inspection, wherein the dopant comprises iodine, wherein the dopant applied is added to the paper slurry or to the adhesive sizing; and forming a roll of adhesive tape with the adhesive applied thereto.
Abase station provided in a radio access network including a plurality of core network slices , the base station comprising: a controller configured to receive, from an upper apparatus of the base station , first information including identification information of each of the plurality of core network slices and a quality of service requirement corresponding to each of the plurality of core network slices , manage a resource allocated to a radio terminal , based on the first information, and provide a Radio Resource Control, RRC, signal related with the resource, to the radio terminal . a controller configured to receive, from an upper apparatus of the base station , first information including identification information of each of the plurality of core network slices and a quality of service requirement corresponding to each of the plurality of core network slices , manage a resource allocated to a radio terminal , based on the first information, and provide a Radio Resource Control, RRC, signal related with the resource, to the radio terminal .
A computer-implemented method for noise attenuation in seismic data, the method comprising: receiving seismic data associated with at least a first vintage (d i ) and a second vintage (d j ) collected for a same subsurface, wherein the first and second vintages (d i , d j ) are taken at different times; calculating a set of filters (f i , fj) that minimizes an energy function E, wherein the energy function E includes a term representing a 4D difference between the first and second vintages (d i , d j ), characterized in that the method further comprises calculating primaries (p i , p j ) corresponding to the first and second vintages (d i , d j ) based on the set of filters (f i , fj); and calculating a 4D difference (Δ ij ) based on the primaries (p i , p j ), wherein the 4D difference (Δ ij ) is minimized, wherein the energy function E is given, either by: wherein λ and δ are constants, n is the number of vintages, M i is a multiple model in matrix form, and || || 2 is an L2 norm, or by: wherein n is the number of vintages, f ij is a filter corresponding to a pair of vintages, m i is a multiple model in vector form, and || || 2 is an L2 norm. receiving seismic data associated with at least a first vintage (d i ) and a second vintage (d j ) collected for a same subsurface, wherein the first and second vintages (d i , d j ) are taken at different times; calculating a set of filters (f i , fj) that minimizes an energy function E, wherein the energy function E includes a term representing a 4D difference between the first and second vintages (d i , d j ), characterized in that the method further comprises calculating primaries (p i , p j ) corresponding to the first and second vintages (d i , d j ) based on the set of filters (f i , fj); and calculating a 4D difference (Δ ij ) based on the primaries (p i , p j ), wherein the 4D difference (Δ ij ) is minimized, wherein the energy function E is given, either by: wherein λ and δ are constants, n is the number of vintages, M i is a multiple model in matrix form, and || || 2 is an L2 norm, or by: wherein n is the number of vintages, f ij is a filter corresponding to a pair of vintages, m i is a multiple model in vector form, and || || 2 is an L2 norm.
An isolated immunoresponsive cell comprising: 1) an antigen recognizing receptor that is a chimeric antigen receptor (CAR) or a T cell receptor (TCR) and that binds to a first antigen, wherein the binding of the receptor to the first antigen is capable of activating the immunoresponsive cell, and 2) a soluble single-chain variable fragment (scFv) that binds to a polypeptide that has immunosuppressive activity or immunostimulatory activity. 1) an antigen recognizing receptor that is a chimeric antigen receptor (CAR) or a T cell receptor (TCR) and that binds to a first antigen, wherein the binding of the receptor to the first antigen is capable of activating the immunoresponsive cell, and 2) a soluble single-chain variable fragment (scFv) that binds to a polypeptide that has immunosuppressive activity or immunostimulatory activity.
A solid form comprising cannabidiol and the coformer tetramethylpyrazine.
A battery formation/testing controller for controlling a formation/testing current of a battery cell and for coupling to a current sensor arranged to output a measurement of battery cell current, the battery formation/testing controller being characterised by being configured to: determine a current feedback measurement indicative of the formation/testing current of the battery cell, wherein determination of the current feedback measurement is based on a transfer function of the current sensor and the measurement of the battery cell current; and control the formation/testing current of the battery cell based on a target formation/testing current and the determined current feedback measurement. determine a current feedback measurement indicative of the formation/testing current of the battery cell, wherein determination of the current feedback measurement is based on a transfer function of the current sensor and the measurement of the battery cell current; and control the formation/testing current of the battery cell based on a target formation/testing current and the determined current feedback measurement.
Cannabidiolic acid (CBDA) for use in the treatment of one or more symptoms or disease characteristics associated with autistic spectrum disorder (ASD) or ASD-associated disorders, as defined by DSM-IV, wherein the symptoms or disease characteristics is one or more selected from the group consisting of: (i) qualitative impairment in social interaction; (ii) qualitative impairment in communication; and (iii) restricted repetitive and stereotyped patterns of behaviour interest and activities, wherein the CBDA is in a substantially pure or is present as a synthetic compound.
A tire vulcanizing mold configured to mold a tire (T1, T2) provided with a bead part having a bead heel part from an unvulcanized tire (T) formed as an unvulcanized pneumatic tire, comprising a side part ring which molds at least the bead part , wherein one circumferential direction groove part recessed toward an outer side in a tire width direction (W) and extending in a tire circumferential direction (C) is formed in a heel molding region (A232), which molds the bead heel part , of a tire molding surface of the side part ring , and the side part ring is divided into a side ring arranged at an outer side in a tire radial direction (D) and a bead ring arranged at an inner side of the side ring in the tire radial direction (D) and contacted with the side ring , characterised in that : a dividing position between a tire molding surface of the side ring and a tire molding surface of the bead ring is arranged on a groove bottom of the one circumferential direction groove part , a cross-sectional shape of the one circumferential direction groove part is formed in a tapered shape in which a groove width becomes smaller toward the groove bottom , and the side ring has a chamfered part on an end part of the side ring at a side of the dividing position , wherein a cross-sectional shape of the chamfered part is formed in an arc shape. a dividing position between a tire molding surface of the side ring and a tire molding surface of the bead ring is arranged on a groove bottom of the one circumferential direction groove part , a cross-sectional shape of the one circumferential direction groove part is formed in a tapered shape in which a groove width becomes smaller toward the groove bottom , and the side ring has a chamfered part on an end part of the side ring at a side of the dividing position , wherein a cross-sectional shape of the chamfered part is formed in an arc shape.
A method for manufacturing a mouthpiece , wherein the mouthpiece is to be placed within an oral cavity to cover teeth and manufactured by an additive manufacturing device , the method comprising: performing additive manufacturing for manufacturing a manufactured product that comprises the mouthpiece , a peripheral portion connected to the mouthpiece , and a plurality of supports configured to support the peripheral portion , and removing the peripheral portion from the manufactured product , wherein the peripheral portion is formed to cover and extend along the gingiva of the oral cavity of a patient, and the plurality of supports are connected to a bottom end of the peripheral portion to support the peripheral portion . performing additive manufacturing for manufacturing a manufactured product that comprises the mouthpiece , a peripheral portion connected to the mouthpiece , and a plurality of supports configured to support the peripheral portion , and removing the peripheral portion from the manufactured product , wherein the peripheral portion is formed to cover and extend along the gingiva of the oral cavity of a patient, and the plurality of supports are connected to a bottom end of the peripheral portion to support the peripheral portion .
An azeotrope or azeotrope-like composition, comprising: i) 75 to 85 weight percent trans-1,2-dichloroethylene; ii) 1 to 5 weight percent methyl perfluoroheptene ether; iii) 10 to 15 weight percent 1,1,2,2,3,3,4-heptafluorocyclopentane; and iv) 1 to 5 weight percent ethanol or isopropanol. i) 75 to 85 weight percent trans-1,2-dichloroethylene; ii) 1 to 5 weight percent methyl perfluoroheptene ether; iii) 10 to 15 weight percent 1,1,2,2,3,3,4-heptafluorocyclopentane; and iv) 1 to 5 weight percent ethanol or isopropanol.
A board panel with a rectangular top, said board panel having in use an upper horizontal side, a lower horizontal side, a front face, a rear face and vertical sides, wherein the board panel has three stacked layers comprising a hard material and a soft material ; wherein the front face layer is a layer of a hard material in which slits are provided in parallel with the vertical side of said board panel with rectangular top; wherein said slits have a length of 1/2 to 3/4 of the length of said vertical side, and one end of said slits touches an horizontal side of said board panel with rectangular top; and wherein said slits include a type of upper slits (5a, 5b...) in which one end of said upper slits touches the upper horizontal side of said board panel, and another type of lower slits (6a, 6b...) in which one end of said lower slits touches the lower horizontal side of said board panel with rectangular top. the front face layer is a layer of a hard material in which slits are provided in parallel with the vertical side of said board panel with rectangular top; wherein said slits have a length of 1/2 to 3/4 of the length of said vertical side, and one end of said slits touches an horizontal side of said board panel with rectangular top; and wherein said slits include a type of upper slits (5a, 5b...) in which one end of said upper slits touches the upper horizontal side of said board panel, and another type of lower slits (6a, 6b...) in which one end of said lower slits touches the lower horizontal side of said board panel with rectangular top.
A magnetic attraction toy, comprising a base , a cover body , a magnetic attraction member and a mounting frame , wherein the magnetic attraction member is connected with the mounting frame ; the base and/or the cover body is provided with a limiting gap for accommodating the magnetic attraction member ; the base is also provided with locating pillars; the mounting frame is provided with locating holes; when the locating holes sleeve the locating pillars, the cover body is covered on the base to stop the mounting frame in the base and to stop the magnetic attraction member in the limiting gap ; the magnetic attraction toy is characterized that, the magnetic attraction member comprises a hollow iron tube and a magnet ; the magnet is located in the iron tube ; one end of the iron tube is provided with a first opening ; the other end of the iron tube is provided with a second opening ; the mounting frame comprises a first clamping piece and a second clamping piece ; the first clamping piece is provided with a first connection end and a first clamping end ; the second clamping piece is provided with a second connection end and a second clamping end ; when the first clamping end is plugged to the first opening , and the second clamping end is plugged to the second opening , the first connection end is connected to the second connection end , so that the first clamping piece and the second clamping piece clamp the iron tube , and the magnetic attraction member and the mounting frame are combined into a whole; wherein the base is also provided with locating pillars ; the mounting frame is provided with locating holes ; when the locating holes sleeve the locating pillars , the cover body is covered on the base to stop the mounting frame in the base and to stop the magnetic attraction member in the limiting gap . the magnetic attraction toy is characterized that, the magnetic attraction member comprises a hollow iron tube and a magnet ; the magnet is located in the iron tube ; one end of the iron tube is provided with a first opening ; the other end of the iron tube is provided with a second opening ; the mounting frame comprises a first clamping piece and a second clamping piece ; the first clamping piece is provided with a first connection end and a first clamping end ; the second clamping piece is provided with a second connection end and a second clamping end ; when the first clamping end is plugged to the first opening , and the second clamping end is plugged to the second opening , the first connection end is connected to the second connection end , so that the first clamping piece and the second clamping piece clamp the iron tube , and the magnetic attraction member and the mounting frame are combined into a whole; wherein the base is also provided with locating pillars ; the mounting frame is provided with locating holes ; when the locating holes sleeve the locating pillars , the cover body is covered on the base to stop the mounting frame in the base and to stop the magnetic attraction member in the limiting gap .