mhurhangee/patent-ind-claim-en huggingface dataset:
A needle actuator assembly for a drug delivery system , the needle actuator assembly comprising: a needle actuator body having a guide surface , the needle actuator body being configured to move between a pre-use position and a post-use position; a needle shuttle having a cam surface , the needle shuttle moveable along a vertical axis between a first position and a second position, the needle shuttle configured to move between the first and second position responsive to the movement of the needle actuator body in which the guide surface of the needle actuator body engages and applies a mechanical force to the cam surface of the needle shuttle to move the needle shuttle ; and a needle received by the needle shuttle , the needle actuator assembly characterized by the needle shuttle comprising a biasing member configured to move the needle shuttle from the first position to the second position with the guide surface of the needle actuator body disengaged from the cam surface of the needle shuttle , and when the needle actuator body is fully transitioned to the post-use position, the cam surface of the needle shuttle is disengaged from the guide surface of the needle actuator body and the shuttle biasing member biases the needle shuttle such that the needle engages a pad of the drug delivery system. a needle actuator body having a guide surface , the needle actuator body being configured to move between a pre-use position and a post-use position; a needle shuttle having a cam surface , the needle shuttle moveable along a vertical axis between a first position and a second position, the needle shuttle configured to move between the first and second position responsive to the movement of the needle actuator body in which the guide surface of the needle actuator body engages and applies a mechanical force to the cam surface of the needle shuttle to move the needle shuttle ; and a needle received by the needle shuttle , the needle actuator assembly characterized by the needle shuttle comprising a biasing member configured to move the needle shuttle from the first position to the second position with the guide surface of the needle actuator body disengaged from the cam surface of the needle shuttle , and when the needle actuator body is fully transitioned to the post-use position, the cam surface of the needle shuttle is disengaged from the guide surface of the needle actuator body and the shuttle biasing member biases the needle shuttle such that the needle engages a pad of the drug delivery system.
A method of storing file system data, comprising: determining a corresponding chunk size for a plurality of component chunks of file system data, wherein the corresponding determined chunk size is configured to provide a desired performance with respect to de-duplication of the file system data; combining a subset of the plurality of component chunks of the file system data into an object, wherein the file system data is comprised of a plurality of objects, wherein each of the plurality of objects is comprised of a corresponding subset of the plurality of component chunks of the file system data; determining for the object associated with a plurality of component chunks of file system data a primary encryption key; using the primary encryption key to generate for each of said component chunks a corresponding chunk key, based at least in part on the primary encryption key and data comprising or otherwise associated with the chunk; and providing the respective chunk keys to a file system client configured to create and store the object at least in part by encrypting each chunk included in the plurality of component chunks using the chunk key provided for that chunk to generated encrypted chunk data, and combining the encrypted chunk data to create and store the object. determining a corresponding chunk size for a plurality of component chunks of file system data, wherein the corresponding determined chunk size is configured to provide a desired performance with respect to de-duplication of the file system data; combining a subset of the plurality of component chunks of the file system data into an object, wherein the file system data is comprised of a plurality of objects, wherein each of the plurality of objects is comprised of a corresponding subset of the plurality of component chunks of the file system data; determining for the object associated with a plurality of component chunks of file system data a primary encryption key; using the primary encryption key to generate for each of said component chunks a corresponding chunk key, based at least in part on the primary encryption key and data comprising or otherwise associated with the chunk; and providing the respective chunk keys to a file system client configured to create and store the object at least in part by encrypting each chunk included in the plurality of component chunks using the chunk key provided for that chunk to generated encrypted chunk data, and combining the encrypted chunk data to create and store the object.
An automatic coffee machine with a mains water connection and further comprising a water tank, a pump, a brewing unit, a coffee line with a spout and an automatic drainage system, wherein a water amount is calculated based on a consumer behavior by a calculating system of the coffee machine which calculates the water amount based on information from a flow meter and the water tank is filled up with a variable amount of water depending on the data received from the calculating system and the water tank is automatically emptied after each deactivation of the coffee machine and/or is automatically refilled after each activation of the coffee machine.
A composition comprising an enzyme associated with a lysosomal storage disease (LSD) and an antigen-binding protein, wherein the enzyme is selected from the group consisting of α-galactosidase, β-galactosidase, α-glucosidase (GAA), β-glucosidase, saposin-C activator, ceramidase, sphingomyelinase, β-hexosaminidase, GM2 activator, GM3 synthase, arylsulfatase, sphingolipid activator, α-iduronidase, iduronidase-2-sulfatase, heparin N-sulfatase, N-acetyl-α-glucosaminidase, α-glucosamide N-acetyltransferase, N-acetylglucosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, N-acetylgalactosamine-4-sulfatase, β-glucuronidase, hyaluronidase, and lysosomal acid lipase (LAL), wherein the antigen-binding protein binds an internalization effector, and wherein the internalization effector is Integrin alpha-7 (ITGA7). wherein the enzyme is selected from the group consisting of α-galactosidase, β-galactosidase, α-glucosidase (GAA), β-glucosidase, saposin-C activator, ceramidase, sphingomyelinase, β-hexosaminidase, GM2 activator, GM3 synthase, arylsulfatase, sphingolipid activator, α-iduronidase, iduronidase-2-sulfatase, heparin N-sulfatase, N-acetyl-α-glucosaminidase, α-glucosamide N-acetyltransferase, N-acetylglucosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, N-acetylgalactosamine-4-sulfatase, β-glucuronidase, hyaluronidase, and lysosomal acid lipase (LAL), wherein the antigen-binding protein binds an internalization effector, and wherein the internalization effector is Integrin alpha-7 (ITGA7).
Method for producing a cold or hot rolled steel strip comprising a metal coating, the steel strip comprising iron as the main component and, in addition to carbon, an Mn content of 8.1 to 25.0 wt.% and optionally one or more of the alloying elements Al, Si, Cr, B, Ti, V, Nb and/or Mo, wherein the surface of the uncoated steel strip is first cleaned, a layer of pure iron having an average iron content of greater than 96 wt.% is applied to the cleaned surface, an oxygen-containing, iron-based layer containing greater than 5 mass percent of oxygen is applied to the layer of pure iron, the steel strip is then subjected to annealing treatment together with the oxygen-containing, iron-based layer and, during the annealing, is subjected to reduction treatment in a reducing furnace atmosphere, and finally the steel strip thus treated and annealed is subjected to hot dip coating with the metal coating.
A skin care composition comprising: (a) 0.1 - 50 wt. % of at least one cyclic diester of an alpha hydroxy acid; and (b) 50 - 99.9 wt. % of at least one polar non-aqueous solvent having a polarity of 5 to 20, as defined in C.M. Hansen, Hansen Solubility Parameters: A User's Handbook, 2nd edition 2007; wherein the composition comprises less than 1 wt. % of water and the at least one polar non-aqueous solvent is a solvent of formula (III), formula (IV), or mixtures thereof: wherein R 6 is an alkyl, ether, ester, amide, amine, or combinations thereof; a is 1 to 3; b is 1 to 5; and z is 1 to 3. (a) 0.1 - 50 wt. % of at least one cyclic diester of an alpha hydroxy acid; and (b) 50 - 99.9 wt. % of at least one polar non-aqueous solvent having a polarity of 5 to 20, as defined in C.M. Hansen, Hansen Solubility Parameters: A User's Handbook, 2nd edition 2007;
A method for monitoring the state of a device in a process industry, characterized in that the method comprises: collecting and saving (S101) data of multi-dimensional states of a device in the process industry; adopting (S102) a preset correlation analysis algorithm to perform a correlation analysis of the collected data of the multi-dimensional states of the device to obtain correlated dimensional state, wherein a dimensional state is used as a target state and the correlation analysis algorithm is used to analyze which of the dimensional states are correlated to the target state; acquiring (S103) history data of correlated dimensional states according to the obtained correlated state dimensions; adopting (S103) a preset algorithm to model the acquired history data of correlated dimensional states to obtain a device state reference model; acquiring (S104) real-time data of correlated dimensional states of the device state reference model in real time; and determining (S104) whether a current state of the device is normal wherein, if the difference between a data value of a target state calculated according to the device state reference model from the real-time data and an actual target state data value is less than a preset threshold, the target state is considered normal, otherwise, the target state is abnormal. collecting and saving (S101) data of multi-dimensional states of a device in the process industry; adopting (S102) a preset correlation analysis algorithm to perform a correlation analysis of the collected data of the multi-dimensional states of the device to obtain correlated dimensional state, wherein a dimensional state is used as a target state and the correlation analysis algorithm is used to analyze which of the dimensional states are correlated to the target state; acquiring (S103) history data of correlated dimensional states according to the obtained correlated state dimensions; adopting (S103) a preset algorithm to model the acquired history data of correlated dimensional states to obtain a device state reference model; acquiring (S104) real-time data of correlated dimensional states of the device state reference model in real time; and determining (S104) whether a current state of the device is normal wherein, if the difference between a data value of a target state calculated according to the device state reference model from the real-time data and an actual target state data value is less than a preset threshold, the target state is considered normal, otherwise, the target state is abnormal.
An image forming apparatus comprising: a medium supplier configured to supply a print medium (M) wound in a roll shape; a medium conveyor configured to intermittently convey the print medium supplied by the medium supplier by a predetermined supply amount; a medium winder configured to wind the print medium conveyed by the medium conveyor; a printer configured to print on the print medium conveyed by the medium conveyor; and a rotation controller configured to: cause the medium supplier to rotate in a medium winding direction at a predetermined timing after the medium conveyor has started to intermittently convey the print medium; and cause the medium supplier to rotate in a reverse direction opposite the medium winding direction to loosen the print medium. a medium supplier configured to supply a print medium (M) wound in a roll shape; a medium conveyor configured to intermittently convey the print medium supplied by the medium supplier by a predetermined supply amount; a medium winder configured to wind the print medium conveyed by the medium conveyor; a printer configured to print on the print medium conveyed by the medium conveyor; and a rotation controller configured to: cause the medium supplier to rotate in a medium winding direction at a predetermined timing after the medium conveyor has started to intermittently convey the print medium; and cause the medium supplier to rotate in a reverse direction opposite the medium winding direction to loosen the print medium. cause the medium supplier to rotate in a medium winding direction at a predetermined timing after the medium conveyor has started to intermittently convey the print medium; and cause the medium supplier to rotate in a reverse direction opposite the medium winding direction to loosen the print medium.
A chimeric polynucleotide encoding a polypeptide, wherein said chimeric polynucleotide has a sequence comprising Formula II: [A n ]-L 1 -[B o ] Formula II wherein each A and B independently comprises any nucleoside; n and o are, independently 10 to 1000, wherein [A n ] or [B o ] independently comprise an mRNA, said mRNA comprising a 5' untranslated region (UTR), 3'UTR and a coding region; and L 1 comprises the structure wherein L 1 is attached to [A n ] at the 3' or 4' position of the sugar of one of the nucleosides and to [B o ] at the 5' or 6' position of the sugar of one of the nucleosides. n and o are, independently 10 to 1000, wherein [A n ] or [B o ] independently comprise an mRNA, said mRNA comprising a 5' untranslated region (UTR), 3'UTR and a coding region; and L 1 comprises the structure wherein L 1 is attached to [A n ] at the 3' or 4' position of the sugar of one of the nucleosides and to [B o ] at the 5' or 6' position of the sugar of one of the nucleosides.
Lidar sensor for detecting an object in the surrounding area, having at least • a light source for emitting electromagnetic radiation, • a deflection mirror for deflecting the emitted electromagnetic radiation by at least one angle into the surrounding area, wherein the deflection mirror is designed as a micromechanical deflection mirror, • an optical receiver for receiving electromagnetic radiation , which has been reflected by the object, and • a mirror for steering the received electromagnetic radiation onto the optical receiver , wherein the mirror has a hole , and wherein • the hole is arranged on a main axis of emission of the light source , characterized in that the lidar sensor furthermore has • a field of micro-optical elements (203-1, 203-2); wherein • the deflection mirror and the field are arranged such that the at least one angle is assigned to exactly one micro-optical element (203-1, 203-2); and wherein the lidar sensor furthermore has • a light-focusing element arranged at a distance (y) from the field of micro-optical elements (203-1, 203-2), wherein • each of the micro-optical elements (203-1, 203-2), when it is impinged upon by the deflected emitted electromagnetic radiation (105-1), expands this deflected emitted electromagnetic radiation (105-1) into a divergent beam ; and wherein • the light-focusing element reshapes the divergent beam into a scanning beam . • a light source for emitting electromagnetic radiation, • a deflection mirror for deflecting the emitted electromagnetic radiation by at least one angle into the surrounding area, wherein the deflection mirror is designed as a micromechanical deflection mirror, • an optical receiver for receiving electromagnetic radiation , which has been reflected by the object, and • a mirror for steering the received electromagnetic radiation onto the optical receiver , wherein the mirror has a hole , and wherein • the hole is arranged on a main axis of emission of the light source , • a field of micro-optical elements (203-1, 203-2); wherein • the deflection mirror and the field are arranged such that the at least one angle is assigned to exactly one micro-optical element (203-1, 203-2); and wherein the lidar sensor furthermore has • a light-focusing element arranged at a distance (y) from the field of micro-optical elements (203-1, 203-2), wherein • each of the micro-optical elements (203-1, 203-2), when it is impinged upon by the deflected emitted electromagnetic radiation (105-1), expands this deflected emitted electromagnetic radiation (105-1) into a divergent beam ; and wherein • the light-focusing element reshapes the divergent beam into a scanning beam .
A tire rubber composition comprising 100 parts by mass of a diene rubber (A) and from 1 to 50 parts by mass of elastic microparticles (B), wherein the elastic microparticles (B) have a form of microparticles obtained by crosslinking a crosslinkable oligomer or polymer (b1) in water or an organic solvent or in the diene rubber (A), and have an average particle size of from 0.001 to 100 μm, the JIS A hardness of a cured product obtained by crosslinking the crosslinkable oligomer or polymer (b1) without use of water, the organic solvent or the diene rubber (A) is greater than 45, wherein the JIS A hardness represents a durometer hardness specified in JIS K 6253-3:2012 measured at a temperature of 25°C by a type A durometer, and the elongation of the cured product is 200% or greater, wherein the elongation represents elongation at break measured at 25°C by cutting out the cured product into the JIS No. 3 dumbbell-shaped test piece and carrying out a tensile test at a tensile speed of 500 mm/min in accordance with JIS K 6251:2010, the crosslinkable oligomer or polymer (b1) is a polyether-based, polyester-based, polyolefin-based, polycarbonate-based, aliphatic, saturated hydrocarbon-based, acrylic, plant-derived or siloxane-based polymer or copolymer, the crosslinkable oligomer or polymer (b1) has a crosslinkable functional group selected from the group consisting of a hydroxyl group, a hydrolyzable silyl group, a silanol group, an isocyanate group, a (meth)acryloyl group, an allyl group, a carboxy group, an acid anhydride group, and an epoxy group, and the elastic microparticles (B) contain a component having a mercapto group or a sulfide bond on the surface of the elastic microparticles (B).
A device for attaching an object to a support element and/or for stabilizing the support element , wherein the device comprises a condition monitoring for determining a deformation, the device comprising: an attachment body having an attachment portion for insertion into the support element , a conductor trace which is electrically conductive and applied along a trace-shaped path for measuring a mechanical tension at the attachment portion , wherein the attachment body comprises a coupling portion for coupling with an evaluation unit , wherein the conductor trace is designed such that it is suppliable with electrical energy from the coupling portion , wherein the electrical resistance of the conductor trace is indicative for the deformation of the attachment body in the attachment portion , wherein the trace-shaped path of the conductor trace protrudes in the coupling portion such that an electrical conductivity is present between the conductor trace in the coupling portion and the attachment portion . an attachment body having an attachment portion for insertion into the support element , a conductor trace which is electrically conductive and applied along a trace-shaped path for measuring a mechanical tension at the attachment portion , wherein the attachment body comprises a coupling portion for coupling with an evaluation unit , wherein the conductor trace is designed such that it is suppliable with electrical energy from the coupling portion , wherein the electrical resistance of the conductor trace is indicative for the deformation of the attachment body in the attachment portion , wherein the trace-shaped path of the conductor trace protrudes in the coupling portion such that an electrical conductivity is present between the conductor trace in the coupling portion and the attachment portion .
A method for producing an antibody-drug conjugate composition, comprising: (i) a step of reacting an antibody with a reducing agent in a buffer to reduce interchain disulfides; and (ii) a step of reacting drug linker intermediates with the antibody having thiol groups obtained in the step (i), wherein the antibody has isotype IgG1, the reducing agent is tris(2-carboxyethyl)phosphine or a salt thereof, the reducing agent is used in an amount of 2 to 3 molar equivalents per molecule of the antibody, the buffer comprises a chelating agent, and the chelating agent is ethylenediaminetetraacetic acid, the reaction time in the step (i) is 5 to 10 hours, the reaction temperature in the step (i) is 0°C to 1°C, the drug linker intermediate is wherein -GGFG- represents a tetrapeptide residue consisting of glycine-glycine-phenylalanine-glycine, and the average number of bound drugs in the produced antibody-drug conjugate composition is 3.5 to 4.5, and the content of the antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, in the produced antibody-drug conjugate composition is 50% or more. (i) a step of reacting an antibody with a reducing agent in a buffer to reduce interchain disulfides; and (ii) a step of reacting drug linker intermediates with the antibody having thiol groups obtained in the step (i), wherein the antibody has isotype IgG1, the reducing agent is tris(2-carboxyethyl)phosphine or a salt thereof, the reducing agent is used in an amount of 2 to 3 molar equivalents per molecule of the antibody, the buffer comprises a chelating agent, and the chelating agent is ethylenediaminetetraacetic acid, the reaction time in the step (i) is 5 to 10 hours, the reaction temperature in the step (i) is 0°C to 1°C, the drug linker intermediate is wherein -GGFG- represents a tetrapeptide residue consisting of glycine-glycine-phenylalanine-glycine, and the average number of bound drugs in the produced antibody-drug conjugate composition is 3.5 to 4.5, and the content of the antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, in the produced antibody-drug conjugate composition is 50% or more. the antibody has isotype IgG1, the reducing agent is tris(2-carboxyethyl)phosphine or a salt thereof, the reducing agent is used in an amount of 2 to 3 molar equivalents per molecule of the antibody, the buffer comprises a chelating agent, and the chelating agent is ethylenediaminetetraacetic acid, the reaction time in the step (i) is 5 to 10 hours, the reaction temperature in the step (i) is 0°C to 1°C, the drug linker intermediate is wherein -GGFG- represents a tetrapeptide residue consisting of glycine-glycine-phenylalanine-glycine, and the average number of bound drugs in the produced antibody-drug conjugate composition is 3.5 to 4.5, and the content of the antibody-drug conjugates in which four drug linkers are bound to heavy-light interchain thiols, in the produced antibody-drug conjugate composition is 50% or more.