A compound having Formula II: or a pharmaceutically acceptable salt or hydrate thereof, wherein: R 1 is selected from the group consisting of hydrogen and C 1-4 alkyl; R 2a and R 2b are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; R 3a and R 3b are each hydrogen; R 4 is aralkyl; Y is -O-; B is selected from the group consisting of: L is selected from the group consisting of alkylenyl, heteroalkylenyl, -A-(CH 2 ) m -W-(CH 2 ) n -, -(CH 2 ) m -W-(CH 2 ) u -O-(CH 2 ) v -, and -(CH 2 ) m -W-[(CH 2 ) w -O] x -(CH 2 ) v -; or L is absent; A is selected from the group consisting of 5-membered heteroarylenyl and 6-membered heteroarylenyl; or A is absent; W is selected from the group consisting of phenylenyl, 5-membered heteroarylenyl, 6-membered heteroarylenyl, heterocyclenyl, and cycloalkylenyl; m is 0, 1, 2, 3, 4, 5, 6, or 7; n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; u is 0, 1, 2, or 3; v is 1, 2, 3, or 4; each w is independently 2, 3, or 4; x is 2, 3, or 4; X is selected from the group consisting of -C=C-, -CH 2 -, -O-, -N(R 2c )-, -C(=O)N(R 2d )-, -N(R 2e )C(=O)CH 2 O-, and -N(R 2f )C(=O)CH 2N (R 2g )-; or X is absent; wherein the carboxamide nitrogen atom of -N(R 2e )C(=O)CH 2 O- and -N(R 2f )C(=O)CH 2 N(R 2g )-, and the carbon atom of -C(=O)N(R 2d )- is attached to L; R 2c , R 2d , R 2e , R 2f , and R 2g are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; Z is selected from the group consisting of -CH 2 and -C(=O)-; R 5 is selected from the group consisting of hydrogen, methyl, and fluoro; A 1 is -C(R 16a )=; A 2 is -C(R 16b )=; A 3 is -C(R 16c )=; R 16a is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl; R 16b is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl; and R 16c is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl. R 1 is selected from the group consisting of hydrogen and C 1-4 alkyl; R 2a and R 2b are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; R 3a and R 3b are each hydrogen; R 4 is aralkyl; Y is -O-; B is selected from the group consisting of: L is selected from the group consisting of alkylenyl, heteroalkylenyl, -A-(CH 2 ) m -W-(CH 2 ) n -, -(CH 2 ) m -W-(CH 2 ) u -O-(CH 2 ) v -, and -(CH 2 ) m -W-[(CH 2 ) w -O] x -(CH 2 ) v -; or L is absent; A is selected from the group consisting of 5-membered heteroarylenyl and 6-membered heteroarylenyl; or A is absent; W is selected from the group consisting of phenylenyl, 5-membered heteroarylenyl, 6-membered heteroarylenyl, heterocyclenyl, and cycloalkylenyl; m is 0, 1, 2, 3, 4, 5, 6, or 7; n is 0, 1, 2, 3, 4, 5, 6, 7, or 8; u is 0, 1, 2, or 3; v is 1, 2, 3, or 4; each w is independently 2, 3, or 4; x is 2, 3, or 4; X is selected from the group consisting of -C=C-, -CH 2 -, -O-, -N(R 2c )-, -C(=O)N(R 2d )-, -N(R 2e )C(=O)CH 2 O-, and -N(R 2f )C(=O)CH 2N (R 2g )-; or X is absent; wherein the carboxamide nitrogen atom of -N(R 2e )C(=O)CH 2 O- and -N(R 2f )C(=O)CH 2 N(R 2g )-, and the carbon atom of -C(=O)N(R 2d )- is attached to L; R 2c , R 2d , R 2e , R 2f , and R 2g are each independently selected from the group consisting of hydrogen and C 1-4 alkyl; Z is selected from the group consisting of -CH 2 and -C(=O)-; R 5 is selected from the group consisting of hydrogen, methyl, and fluoro; A 1 is -C(R 16a )=; A 2 is -C(R 16b )=; A 3 is -C(R 16c )=; R 16a is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl; R 16b is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl; and R 16c is selected from the group consisting of hydrogen, halo, and C 1-4 alkyl. <EOS>