Automated system of regulation of a patient's blood glucose, comprising: - a blood glucose sensor ; - an insulin injection device ; and - a processing and control unit , wherein the processing and control unit is configured to implement a hypoglycemia minimization method (HM) comprising the steps of: a) detecting a possible hypoglycemia to come based on blood glucose measurements supplied by the blood glucose sensor; b) determining a value BGdebt representative of a blood glucose debt to be compensated to avoid the hypoglycemia detected at step a) and a value Thypo representative of the time remaining before the beginning of the hypoglycemia detected at step a); c) determining a value Tautosugaring representative of the duration necessary to enable the patient to compensate for the blood glucose debt BGdebt determined at step b) by endogenous glucose production; d) comparing the value Tautosugaring determined at step c) with a value Thypo-TH, where TH is a predetermined time margin; and e) when it is determined at step d) that value Tautosugaring is greater than or equal to value Thypo-TH, controlling the interruption of the insulin flow injected to the patient by the insulin injection device and/or starting an alert via a user interface device of the system to indicate to the patient that they must perform a resugaring, wherein, at step b), the value Thypo is calculated as follows: Thypo = BGlimhypo − BG t0 nGRC where BGlimhypo is a predetermined hypoglycemia threshold, BG(to) is a value representative of the the patient's current blood glucose, measured by the sensor, nGRC is a negative coefficient representative of the patient's blood glucose drop, and wherein, at step c), value Tautosugaring is calculated as follows: Tautosugaring = BGdebt EGE where EGE is a value representative of the patient's endogenous blood glucose rise rate. - a blood glucose sensor ; - an insulin injection device ; and - a processing and control unit , a) detecting a possible hypoglycemia to come based on blood glucose measurements supplied by the blood glucose sensor; b) determining a value BGdebt representative of a blood glucose debt to be compensated to avoid the hypoglycemia detected at step a) and a value Thypo representative of the time remaining before the beginning of the hypoglycemia detected at step a); c) determining a value Tautosugaring representative of the duration necessary to enable the patient to compensate for the blood glucose debt BGdebt determined at step b) by endogenous glucose production; d) comparing the value Tautosugaring determined at step c) with a value Thypo-TH, where TH is a predetermined time margin; and e) when it is determined at step d) that value Tautosugaring is greater than or equal to value Thypo-TH, controlling the interruption of the insulin flow injected to the patient by the insulin injection device and/or starting an alert via a user interface device of the system to indicate to the patient that they must perform a resugaring, wherein, at step b), the value Thypo is calculated as follows: Thypo = BGlimhypo − BG t0 nGRC where BGlimhypo is a predetermined hypoglycemia threshold, BG(to) is a value representative of the the patient's current blood glucose, measured by the sensor, nGRC is a negative coefficient representative of the patient's blood glucose drop, and wherein, at step c), value Tautosugaring is calculated as follows: Tautosugaring = BGdebt EGE where EGE is a value representative of the patient's endogenous blood glucose rise rate. <EOS>