mhurhangee/patent-ind-claim-en huggingface dataset:
A monoclonal antibody, or an antigen-binding portion thereof, that specifically binds to a filovirus, wherein the antibody or antigen-binding portion comprises: (a) an immunoglobulin light chain variable region comprising LCDR1, LCDR2, and LCDR3, and an immunoglobulin heavy chain variable region comprising HCDR1, HCDR2, and HCDR3, wherein the LCDR1, LCDR2 and LCDR3 comprise the amino acid sequences set forth in SEQ ID NOs: 78, 79 and 80, respectively, and the HCDR1, HCDR2, and HCDR3 comprise the amino acid sequences set forth in SEQ ID NOs: 90, 91 and 92, respectively; or (b) an immunoglobulin light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:2 and an immunoglobulin heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:14; or (c) an immunoglobulin light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:26 and an immunoglobulin heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:38. (a) an immunoglobulin light chain variable region comprising LCDR1, LCDR2, and LCDR3, and an immunoglobulin heavy chain variable region comprising HCDR1, HCDR2, and HCDR3, wherein the LCDR1, LCDR2 and LCDR3 comprise the amino acid sequences set forth in SEQ ID NOs: 78, 79 and 80, respectively, and the HCDR1, HCDR2, and HCDR3 comprise the amino acid sequences set forth in SEQ ID NOs: 90, 91 and 92, respectively; or (b) an immunoglobulin light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:2 and an immunoglobulin heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:14; or (c) an immunoglobulin light chain variable region comprising the amino acid sequence set forth in SEQ ID NO:26 and an immunoglobulin heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:38.
Process for converting an aryl/vinyl halide/triflate (I) into an aryl/vinyl nitrile (III) using an alkylnitrile (II) as reagent in the presence of a transition metal coordinated to a ligand and a Lewis acid co-catalyst, and a base, preferably in a solvent, as represented in the following scheme: Wherein: - R c represents a C 3 to C 6 hydrocarbon chain which forms a five to eight-membered optionally substituted hydrocarbon ring system with the vinyl moiety; - X represents halogen or triflate, - R n represents a C 3 to C 12 alkyl group; - the metal of the coordinated transition metal catalyst is Nickel, - the ligand of the coordinated transition metal catalyst is selected from PPh 3 , PCy 3 , P(OPh) 3 , PEt 3 , BINAP, Xanthphos, DuPhos, dppf, dppe and mixtures thereof; - the Lewis acid co-catalyst is selected from AlMe 3 , Al(isobutyl) 3 , AlMe 2 Cl, AlMeCl 2 , AlCl 3 , BPh 3 , B(C 6 F 5 ) 3 , Zn(OTf) 2 , ZnCl 2 , TiCl 4 , Sc(OTf) 3 , , and - the base is selected from common inorganic or organic bases having a moderate basicity with 5 < pKa conjugated acid < 35. - R c represents a C 3 to C 6 hydrocarbon chain which forms a five to eight-membered optionally substituted hydrocarbon ring system with the vinyl moiety; - X represents halogen or triflate, - R n represents a C 3 to C 12 alkyl group; - the metal of the coordinated transition metal catalyst is Nickel, - the ligand of the coordinated transition metal catalyst is selected from PPh 3 , PCy 3 , P(OPh) 3 , PEt 3 , BINAP, Xanthphos, DuPhos, dppf, dppe and mixtures thereof; - the Lewis acid co-catalyst is selected from AlMe 3 , Al(isobutyl) 3 , AlMe 2 Cl, AlMeCl 2 , AlCl 3 , BPh 3 , B(C 6 F 5 ) 3 , Zn(OTf) 2 , ZnCl 2 , TiCl 4 , Sc(OTf) 3 , , and - the base is selected from common inorganic or organic bases having a moderate basicity with 5 < pKa conjugated acid < 35.
A sole structure for an article of footwear comprising: a midsole system including a plurality of cushioning units , each cushioning unit including: a first cushioning layer comprising a first sealed chamber ; and a second cushioning layer comprising a second sealed chamber , the first sealed chamber and the second sealed chamber each retaining gas in isolation from one another; wherein the first cushioning layer underlies the second cushioning layer and has a domed lower surface extending away from the second cushioning layer ; wherein the sole structure further comprises an additional cushioning layer underlying the plurality of cushioning units ; wherein the additional cushioning layer includes a plurality of stanchions ; wherein each stanchion interfaces with the domed lower surface of a respective one of the plurality of cushioning units ; and wherein at least some of the plurality of stanchions have concave upper surfaces each of which cups at least a portion of the domed lower surface of the respective one of the plurality of cushioning units . a midsole system including a plurality of cushioning units , each cushioning unit including: a first cushioning layer comprising a first sealed chamber ; and a second cushioning layer comprising a second sealed chamber , the first sealed chamber and the second sealed chamber each retaining gas in isolation from one another; a first cushioning layer comprising a first sealed chamber ; and a second cushioning layer comprising a second sealed chamber , the first sealed chamber and the second sealed chamber each retaining gas in isolation from one another; wherein the first cushioning layer underlies the second cushioning layer and has a domed lower surface extending away from the second cushioning layer ; wherein the sole structure further comprises an additional cushioning layer underlying the plurality of cushioning units ; wherein the additional cushioning layer includes a plurality of stanchions ; wherein each stanchion interfaces with the domed lower surface of a respective one of the plurality of cushioning units ; and wherein at least some of the plurality of stanchions have concave upper surfaces each of which cups at least a portion of the domed lower surface of the respective one of the plurality of cushioning units .
A composition for use in a method of treating cancer, the composition comprising autologous primary T cells comprising one or more disrupted immunological checkpoint genes, wherein the T cells are genetically altered ex vivo by introduction of: (i) one or more transgenes that encode one or more polypeptides that disrupt genetic expression of the immunological checkpoint gene, and (ii) a guide nucleic acid that binds the immunological checkpoint gene within 5 base pairs of a protospacer adjacent motif (PAM), further wherein the polypeptide is a CRISPR nuclease, further wherein the CRISPR nuclease cleaves the immunological checkpoint gene with an efficiency of 55% or greater.
Air outlet system for a portable dry vacuum cleaner , via which intake air (SL) sucked in by the dry vacuum cleaner can be expelled into the surroundings (U) as exhaust air (AL), characterized in that the air outlet system has an accommodation bay , which is to be arranged in a housing of the dry vacuum cleaner , wherein the accommodation bay is provided for accommodating a modular constituent part of the air outlet system and wherein the modular constituent part of the air outlet system is formed by an outlet adapter having an outlet fitting for the connection of a blower hose or by an air filter cartridge without such an outlet fitting .
Method of combusting aluminium comprising i) feeding aluminium wire to a substantially oxygen-free furnace comprising a. a first low-temperature section in communication with b. a second high-temperature section ii) forming aluminium particles with an average particle size ranging from 1 μm to 200 μm from said aluminium wire in said first section iii) feeding water and/or steam to said first and/or second section to provide an oxidizer for oxidizing said aluminium particles in the second section iv) conveying aluminium particles from the first section to the second section v) oxidizing said aluminium particles in the presence of steam in said second section. i) feeding aluminium wire to a substantially oxygen-free furnace comprising a. a first low-temperature section in communication with b. a second high-temperature section a. a first low-temperature section in communication with b. a second high-temperature section ii) forming aluminium particles with an average particle size ranging from 1 μm to 200 μm from said aluminium wire in said first section iii) feeding water and/or steam to said first and/or second section to provide an oxidizer for oxidizing said aluminium particles in the second section iv) conveying aluminium particles from the first section to the second section v) oxidizing said aluminium particles in the presence of steam in said second section.
A cascade for a jet engine thrust reverser , comprising: a plurality of strongbacks each formed of a polymer resin having a continuous fiber reinforcement; and a plurality of vanes joined to the strongbacks; the cascade characterized in that each of the plurality of vanes is formed of a polymer resin having a discontinuous fiber reinforcement. a plurality of strongbacks each formed of a polymer resin having a continuous fiber reinforcement; and a plurality of vanes joined to the strongbacks; the cascade characterized in that each of the plurality of vanes is formed of a polymer resin having a discontinuous fiber reinforcement.
Assembly for a turbine engine, comprising: - a rotor shaft of a turbine engine , and - at least two bearings making it possible to support at least one portion of said shaft, characterised in that it comprises a bearing support configured to be connected to a casing of the turbine engine and which extends between the inner rings of the bearings by being mounted on the latter, as well as a bearing coupler which is connected to the rotor shaft and which is mounted on the outer rings of the bearings by extending between them, the bearing support and the bearing coupler being common to the two bearings and delimiting at least partially together a chamber for the circulation of oil common to the two bearings . - a rotor shaft of a turbine engine , and - at least two bearings making it possible to support at least one portion of said shaft,
Chassis for a commercial vehicle , in particular for a military commercial vehicle, comprising a chassis frame extending along a longitudinal direction (L) of the chassis , a cross beam firmly connected to the chassis frame for supporting an interchangeable superstructure which can be placed on the chassis , a pendulum cross beam pivotably mounted on the chassis frame for supporting the superstructure , a first swing arm element which is rotatably mounted on the chassis frame about a first axis of rotation and which is rotatably mounted on the pendulum cross beam about a second axis of rotation , and a second swing arm element which is rotatably mounted on the chassis frame about a first axis of rotation and which is rotatably mounted on the pendulum cross beam about a second axis of rotation , wherein an extension of the first swing arm element and an extension of the second swing arm element intersect one another at an instantaneous center which is positioned below the pendulum cross beam , as viewed in a height direction (H) of the chassis , and wherein the two second axes of rotation of the swing arm elements are positioned between the two first axes of rotation of the swing arm elements and the instantaneous center as viewed in the height direction (H). a chassis frame extending along a longitudinal direction (L) of the chassis , a cross beam firmly connected to the chassis frame for supporting an interchangeable superstructure which can be placed on the chassis , a pendulum cross beam pivotably mounted on the chassis frame for supporting the superstructure , a first swing arm element which is rotatably mounted on the chassis frame about a first axis of rotation and which is rotatably mounted on the pendulum cross beam about a second axis of rotation , and a second swing arm element which is rotatably mounted on the chassis frame about a first axis of rotation and which is rotatably mounted on the pendulum cross beam about a second axis of rotation , wherein an extension of the first swing arm element and an extension of the second swing arm element intersect one another at an instantaneous center which is positioned below the pendulum cross beam , as viewed in a height direction (H) of the chassis , and wherein the two second axes of rotation of the swing arm elements are positioned between the two first axes of rotation of the swing arm elements and the instantaneous center as viewed in the height direction (H).
Method for image acquisition of a preferably structured surface of an object , wherein the surface is illuminated by means of at least one pattern projection unit, wherein images of projected patterns are recorded by means of at least one imaging unit , and wherein a temporal and/or spatial evaluation of recorded images or image sequences is carried out in order to reconstruct the surface, characterised in that with the pattern projection unit a predeterminable analogue grey value is depicted by applying a corresponding analogue control voltage or corresponding analogue control voltages, preferably per pixel, and in that , with reference to the temporal and/or spatial evaluation of the recorded images or image sequences, there are established by means of algorithms corresponding image points, which, together with an imaging function, enable a triangulation of surface points.
A method for decoding video, the method comprising: receiving (S1810) video information including information related to a prediction mode, information on a tile and information on a slice, wherein the tile is a common rectangular region of a column of largest coding units (LCUs) and a row of largest coding units (LCUs) and the slice comprises an integer number of largest coding units (LCUs); deriving (S1820) the tile and the slice in a current picture (300; 400; 500; 1110; 1210; 1410) based on the received video information, wherein the current picture (300; 400; 500; 1110; 1210; 1410) includes more than one tile and more than one slice; and performing decoding (S1830) for the current picture (300; 400; 500; 1110; 1210; 1410) based on the more than one tile and the more than one slice, wherein the decoding (S1830) for the current picture (300; 400; 500; 1110; 1210; 1410) includes: performing inter prediction or intra prediction to derive a predicted block of a current block in the current picture based on the information related to the prediction mode; and generating a reconstructed picture of the current picture based on the predicted block, characterized in that the following constraints are imposed: the largest coding units (LCUs) in the slice are ordered consecutively in tile scan order; in the tile scan order, largest coding units (LCUs) in each of the tiles in the slice are ordered in the raster scan order in the each of the tiles , and the tiles in the slice are ordered in the raster scan order; and tile IDs specifying the tiles ordered in the slice are consecutive. receiving (S1810) video information including information related to a prediction mode, information on a tile and information on a slice, wherein the tile is a common rectangular region of a column of largest coding units (LCUs) and a row of largest coding units (LCUs) and the slice comprises an integer number of largest coding units (LCUs); deriving (S1820) the tile and the slice in a current picture (300; 400; 500; 1110; 1210; 1410) based on the received video information, wherein the current picture (300; 400; 500; 1110; 1210; 1410) includes more than one tile and more than one slice; and performing decoding (S1830) for the current picture (300; 400; 500; 1110; 1210; 1410) based on the more than one tile and the more than one slice, performing inter prediction or intra prediction to derive a predicted block of a current block in the current picture based on the information related to the prediction mode; and generating a reconstructed picture of the current picture based on the predicted block, the largest coding units (LCUs) in the slice are ordered consecutively in tile scan order; in the tile scan order, largest coding units (LCUs) in each of the tiles in the slice are ordered in the raster scan order in the each of the tiles , and the tiles in the slice are ordered in the raster scan order; and tile IDs specifying the tiles ordered in the slice are consecutive.
A process for the recovery/purification of a C 4 -C 10 acrylic ester from a crude reaction mixture obtained by direct esterification of acrylic acid by the corresponding alcohol, characterized in that a stream rich in acid impurities, such as β-hydroxypropionic acid and β-acryloyloxypropionic acid, is drawn off via a side outlet during the distillation of the crude reaction mixture.
A method for providing interface tools for manipulating a source document on a display, comprising processing an input byte stream representative of the source document to generate a content document file representative of an internal representation of the content of the source document, said internal representation describing the source document as a collection of pre-defined document objects and parameters defining properties of specific instances of the document objects within the source document; providing a stored tool document file containing, according to the internal representation, a document providing an image that is representative of a graphical tool; providing tool code associated with the tool document file and capable of processing the content document file to create an internal representation of the content that presents the content in a manner that achieves a display effect associated with the tool; and processing the content document file, the tool document file, and the processed internal representation to generate a screen document for display on the display in a manner that portrays the display effect.
A micro electromechanical ink jet printing system comprising: a. a cartridge , that comprises a body that defines a core, a die that comprises one or more nozzles ; b. a treatment composition disposed within the cartridge core; c. a CPU that is programmable and can control the application of the treatment composition from within the cartridge core, through the one or more nozzles to human skin; and, d. wherein the treatment composition comprises a skin treatment ingredient selected from the group consisting of particles, vitamins, yeast and yeast extracts, skin care actives, dyes, colorants and mixtures thereof, characterized in that the treatment composition comprises particles having a refractive index of between 1.1 and 5.0. a. a cartridge , that comprises a body that defines a core, a die that comprises one or more nozzles ; b. a treatment composition disposed within the cartridge core; c. a CPU that is programmable and can control the application of the treatment composition from within the cartridge core, through the one or more nozzles to human skin; and, d. wherein the treatment composition comprises a skin treatment ingredient selected from the group consisting of particles, vitamins, yeast and yeast extracts, skin care actives, dyes, colorants and mixtures thereof, characterized in that the treatment composition comprises particles having a refractive index of between 1.1 and 5.0.
A sorting system , comprising: a conveyor system including a top surface that advances in a forward direction; and one or more blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) positioned over the conveyor system , wherein the blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) extend along the forward advancing direction, wherein the blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) include one or more valved nozzles (206; 304, 306, 308; 406; 522; 524) connected to a pressurized source of a fluid, and wherein the valved nozzles (206; 304, 306, 308; 406; 522; 524) are positioned to discharge the fluid across the conveyor system ;, characterized in that the conveyor system has one or more lane diverter bars (DB, 102, 118, 120, 122, 124) positioned over the top surface of the conveyor system, wherein the lane diverter bars (DB, 102, 118, 120, 122, 124) extend lengthwise along the conveyor system forward advancing direction, and the lateral regions to the left and right of the lane diverter bars (DB, 102, 118, 120, 122, 124) define lane divisions (LD, 126, 128, 130, 132, 134, 136). a conveyor system including a top surface that advances in a forward direction; and one or more blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) positioned over the conveyor system , wherein the blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) extend along the forward advancing direction, wherein the blow off bars (BB; 108, 110, 112, 114, 116; 202; 302; 402; 502) include one or more valved nozzles (206; 304, 306, 308; 406; 522; 524) connected to a pressurized source of a fluid, and wherein the valved nozzles (206; 304, 306, 308; 406; 522; 524) are positioned to discharge the fluid across the conveyor system ;, characterized in that the conveyor system has one or more lane diverter bars (DB, 102, 118, 120, 122, 124) positioned over the top surface of the conveyor system, wherein the lane diverter bars (DB, 102, 118, 120, 122, 124) extend lengthwise along the conveyor system forward advancing direction, and the lateral regions to the left and right of the lane diverter bars (DB, 102, 118, 120, 122, 124) define lane divisions (LD, 126, 128, 130, 132, 134, 136).
A method of wireless communication for a first device, comprising: performing a first key agreement procedure to determine a first shared secret for communicating with a second device, the first shared secret being associated with a first bonding identifier, BI, of the first device and a second BI of the second device; maintaining a first correlation between the first shared secret and the second BI; and performing a key agreement recovery procedure when the first device determines based on an unexpected status of a protocol data unit, PDU, that the second device does not maintain a second correlation between the first shared secret and the first BI, wherein the key agreement recovery procedure comprises aborting a subsequent key agreement procedure using the maintained first correlation and performing a different type of key agreement procedure than the subsequent key agreement procedure. performing a first key agreement procedure to determine a first shared secret for communicating with a second device, the first shared secret being associated with a first bonding identifier, BI, of the first device and a second BI of the second device; maintaining a first correlation between the first shared secret and the second BI; and performing a key agreement recovery procedure when the first device determines based on an unexpected status of a protocol data unit, PDU, that the second device does not maintain a second correlation between the first shared secret and the first BI, wherein the key agreement recovery procedure comprises aborting a subsequent key agreement procedure using the maintained first correlation and performing a different type of key agreement procedure than the subsequent key agreement procedure.