A thrombectomy device , characterized in that the thrombectomy device comprises: a thrombus removal head having at least one opening configured to allow thrombus to enter the thrombus removal head , and the thrombus removal head being connected to a sheath ; a thrombus fragmentation system comprising an operating assembly, a gear assembly , a transmission tube and a thrombus fragmentation cutter , wherein the operating assembly drives the transmission tube to rotate through the gear assembly , and a distal end of the transmission tube is connected to the thrombus fragmentation cutter ; and a thrombus aspiration system comprising a connecting member , an aspiration assembly , a drainage tube and a liquid inlet tube , wherein one end of the connecting member is connected to the operating assembly, and a further end of the connecting member is connected to the aspiration assembly ; when driven by the operating assembly, the connecting member drives the aspiration assembly to form a pressure chamber; the pressure chamber is connected to the drainage tube and the liquid inlet tube ; and the liquid inlet tube is connected to the sheath , wherein the aspiration assembly comprises an aspiration chamber , a piston , and a piston rod ; the piston sleeves over the piston rod and is tangential with an inner surface of the aspiration chamber ; one end of the piston rod away from the piston is connected to the connecting member , and wherein a negative pressure is generated in the pressure chamber when an acting force is applied to the operating assembly, and a positive pressure is generated in the pressure chamber when no acting force is applied to the operating assembly. a thrombus removal head having at least one opening configured to allow thrombus to enter the thrombus removal head , and the thrombus removal head being connected to a sheath ; a thrombus fragmentation system comprising an operating assembly, a gear assembly , a transmission tube and a thrombus fragmentation cutter , wherein the operating assembly drives the transmission tube to rotate through the gear assembly , and a distal end of the transmission tube is connected to the thrombus fragmentation cutter ; and a thrombus aspiration system comprising a connecting member , an aspiration assembly , a drainage tube and a liquid inlet tube , wherein one end of the connecting member is connected to the operating assembly, and a further end of the connecting member is connected to the aspiration assembly ; when driven by the operating assembly, the connecting member drives the aspiration assembly to form a pressure chamber; the pressure chamber is connected to the drainage tube and the liquid inlet tube ; and the liquid inlet tube is connected to the sheath , wherein the aspiration assembly comprises an aspiration chamber , a piston , and a piston rod ; the piston sleeves over the piston rod and is tangential with an inner surface of the aspiration chamber ; one end of the piston rod away from the piston is connected to the connecting member , and wherein a negative pressure is generated in the pressure chamber when an acting force is applied to the operating assembly, and a positive pressure is generated in the pressure chamber when no acting force is applied to the operating assembly. <EOS>