An exercise oral appliance system for a human mouth, positioning a jaw for improved airway configuration to enhance breathing, not intended for use in orthodontic applications, comprising: at least one maxillary appliance , comprising: two maxillary anchor portions for removably anchoring the at least one maxillary appliance to a human maxilla at least at opposed posterior segments thereof; each maxillary anchor portion including mounting receptacles for securely removably receiving at least an M1 maxillary molar tooth and an adjacent PM2 maxillary premolar tooth on one side of the human mouth; at least one mandibular appliance comprising: two mandibular anchor portions for removably anchoring the at least one mandibular appliance to a human mandible at least at opposed posterior segments thereof; each mandibular anchor portion including mounting receptacles for securely removably receiving at least an M1 mandibular molar tooth and an adjacent PM2 mandibular premolar tooth on one side of the human mouth; and biasing members carried by the at least one maxillary appliance and the at least one mandibular appliance; wherein the at least one mandibular appliance is anchored to the human mandible and the at least one maxillary appliance is anchored to the human maxilla of a common jaw , the biasing members act between the at least one maxillary appliance and the at least one mandibular appliance to urge the at least one mandibular appliance inferiorly and anteriorly away from the at least one maxillary appliance with a force between about 2.45 N at contact and about 11.77 N at contact. at least one maxillary appliance , comprising: two maxillary anchor portions for removably anchoring the at least one maxillary appliance to a human maxilla at least at opposed posterior segments thereof; each maxillary anchor portion including mounting receptacles for securely removably receiving at least an M1 maxillary molar tooth and an adjacent PM2 maxillary premolar tooth on one side of the human mouth; two maxillary anchor portions for removably anchoring the at least one maxillary appliance to a human maxilla at least at opposed posterior segments thereof; each maxillary anchor portion including mounting receptacles for securely removably receiving at least an M1 maxillary molar tooth and an adjacent PM2 maxillary premolar tooth on one side of the human mouth; at least one mandibular appliance comprising: two mandibular anchor portions for removably anchoring the at least one mandibular appliance to a human mandible at least at opposed posterior segments thereof; each mandibular anchor portion including mounting receptacles for securely removably receiving at least an M1 mandibular molar tooth and an adjacent PM2 mandibular premolar tooth on one side of the human mouth; and two mandibular anchor portions for removably anchoring the at least one mandibular appliance to a human mandible at least at opposed posterior segments thereof; each mandibular anchor portion including mounting receptacles for securely removably receiving at least an M1 mandibular molar tooth and an adjacent PM2 mandibular premolar tooth on one side of the human mouth; and biasing members carried by the at least one maxillary appliance and the at least one mandibular appliance; wherein the at least one mandibular appliance is anchored to the human mandible and the at least one maxillary appliance is anchored to the human maxilla of a common jaw , the biasing members act between the at least one maxillary appliance and the at least one mandibular appliance to urge the at least one mandibular appliance inferiorly and anteriorly away from the at least one maxillary appliance with a force between about 2.45 N at contact and about 11.77 N at contact. <EOS>