A system for treating benign prostatic hypertrophy, comprising: an anchor assembly; and a delivery device housing the anchor assembly, the delivery device including: (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip , the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip ; and wherein either: (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments , thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source , alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element , the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element . an anchor assembly; and a delivery device housing the anchor assembly, the delivery device including: (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip , the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip ; and wherein either: (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments , thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source , alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element , the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element . (i) a flexible elongate portion extending from a handle, the elongate portion being sized and shaped to be advanced within a prostatic urethra and further comprising an expandable tip , the flexible elongate portion being configured to have a variable and controllable flexibility along at least a portion of its length proximal the expandable tip ; and (a) the flexible elongate portion further comprises a plurality of longitudinally arranged segments and a connecting wire configured to control the distance between the longitudinally arranged segments , thereby providing the variable and controllable flexibility, or (b) the flexible elongate portion further comprises an inflatable shaft configured to be inflated by a pump source , alteration of the pressure provided to the inflatable shaft providing the variable and controllable flexibility; and (ii) a needle deflection mechanism including a pull wire routed over a first fixed element and connected to a second moving element , the needle deflection mechanism configured to project the needle distally between the first fixed element and the second moving element . <EOS>