An ultrasonic cardiac stimulation system comprising: - a means for measuring electrical activity of the heart in order to acquire an electrocardiogram (ECG); - a means for generating a beam of ultrasonic signals (Fus) focused on a targeted zone (Zc), said signals being calibrated to generate electrical stimulation in a zone of the heart, said generating the beam being synchronous with a first selected instant of the electrocardiogram (ECG), generating the beam corresponding to at least one pulse generated in a focused zone (Z F ), an amplitude of the pulses being configured so that the acoustic pressure applied in the focused zone (Z F ) is included: ∘ in a first pressure range (GP2) of [2 - 8 MPa] for pulse durations within a first duration range (GD2) [1 ms - 50 ms], or ∘ in a second pressure range (GP3) of [6 - 12 MPa] for pulse durations within a second duration range (GD3) [50μs - 1ms] and for an application duration greater than 50 μs and less than a pulse threshold duration calculated for a given pulse amplitude; - a means for locating the targeted zone (Zc) coupled to means for positioning the means for generating the focused beam (Fus) so as to feedback control said focused beam of ultrasound signals (Fus) in the targeted zone (Zc), said locating means being synchronised with the means for generating the focused signal beam (Fus); - a same monitoring means capable of following in real time temperature and tissue deformation in the targeted zone (Zc), said monitoring means reading measurements synchronously with the rhythm of the electrocardiogram. - a means for measuring electrical activity of the heart in order to acquire an electrocardiogram (ECG); - a means for generating a beam of ultrasonic signals (Fus) focused on a targeted zone (Zc), said signals being calibrated to generate electrical stimulation in a zone of the heart, said generating the beam being synchronous with a first selected instant of the electrocardiogram (ECG), generating the beam corresponding to at least one pulse generated in a focused zone (Z F ), an amplitude of the pulses being configured so that the acoustic pressure applied in the focused zone (Z F ) is included: ∘ in a first pressure range (GP2) of [2 - 8 MPa] for pulse durations within a first duration range (GD2) [1 ms - 50 ms], or ∘ in a second pressure range (GP3) of [6 - 12 MPa] for pulse durations within a second duration range (GD3) [50μs - 1ms] and for an application duration greater than 50 μs and less than a pulse threshold duration calculated for a given pulse amplitude; ∘ in a first pressure range (GP2) of [2 - 8 MPa] for pulse durations within a first duration range (GD2) [1 ms - 50 ms], or ∘ in a second pressure range (GP3) of [6 - 12 MPa] for pulse durations within a second duration range (GD3) [50μs - 1ms] and for an application duration greater than 50 μs and less than a pulse threshold duration calculated for a given pulse amplitude; - a means for locating the targeted zone (Zc) coupled to means for positioning the means for generating the focused beam (Fus) so as to feedback control said focused beam of ultrasound signals (Fus) in the targeted zone (Zc), said locating means being synchronised with the means for generating the focused signal beam (Fus); - a same monitoring means capable of following in real time temperature and tissue deformation in the targeted zone (Zc), said monitoring means reading measurements synchronously with the rhythm of the electrocardiogram. <EOS>