Apparatus for surface treatment of human and/or animal tissue by using dry ice particles , in particular for surface treatment of human and/or animal skin, comprising: - at least a first inlet port connected to a first source of pressurized liquid carbon dioxide for medical use, - at least a first agglomeration chamber , which is configured for making dry ice snow by delivering pressurized liquid carbon dioxide into said agglomeration chamber and expanding said pressurized liquid carbon dioxide within said agglomeration chamber , wherein the first agglomeration chamber is fluid-connectable or fluid-connected to the first inlet port , - at least a first compressing device being configured for compressing the dry ice snow made in the agglomeration chamber at least partly into compressed dry ice , - at least a first shredding device (12, 12', 12") being configured for shredding the compressed dry ice at least partly into dry ice particles , and - an outlet for discharging the dry ice particles , wherein the apparatus is configured for making dry ice particles for medical use, wherein the apparatus is further configured for generating a medical particle jet comprising a medical carrier fluid and medical dry ice particles , wherein the apparatus comprises a mixing device having a mixing chamber , wherein the mixing chamber in particular comprises a fluid inlet for the medical carrier fluid flow, a particle inlet for supply with medical dry ice particles , and a particle jet outlet for discharging the particle jet generated, characterized in that the apparatus further comprises an application device , wherein the application device is fluid-connected to the particle jet outlet of the mixing device and comprises a first outlet for discharging a particle jet and in particular a carrier fluid flow and at least a second outlet for discharging at least a carrier fluid , and the apparatus being further configured for local cryotherapy treatment of human and/or animal tissue by direct application of medical carbon dioxide and/or medical nitrogen to the tissue, wherein the apparatus comprises at least one supply line for direct fluid-connection from a source of medical liquid carbon dioxide and/or medical liquid nitrogen to the application device . - at least a first inlet port connected to a first source of pressurized liquid carbon dioxide for medical use, - at least a first agglomeration chamber , which is configured for making dry ice snow by delivering pressurized liquid carbon dioxide into said agglomeration chamber and expanding said pressurized liquid carbon dioxide within said agglomeration chamber , wherein the first agglomeration chamber is fluid-connectable or fluid-connected to the first inlet port , - at least a first compressing device being configured for compressing the dry ice snow made in the agglomeration chamber at least partly into compressed dry ice , - at least a first shredding device (12, 12', 12") being configured for shredding the compressed dry ice at least partly into dry ice particles , and - an outlet for discharging the dry ice particles , wherein the apparatus is configured for making dry ice particles for medical use, <EOS>