A system for microbubble-enhanced treatment of target tissue, the system comprising: an ultrasound transducer; an administration device for administering an exogenous agent; a monitoring system for measuring at least one parameter value associated with at least one of (i) the ultrasound transducer, or (ii) the exogenous agent, wherein the monitoring system is further configured to measure a physiological parameter value associated with the target tissue or non-target tissue; wherein the monitoring system comprises a biosensor, wherein the physiological parameter value comprises at least one of a blood pressure, a blood circulation rate, a blood perfusion rate, a blood oxygen level or a heart rate; and at least one controller configured to: (a) generate a treatment plan based at least in part on the measured at least one parameter value; (b) cause administration of the exogenous agent; (c) cause the ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; (d) receive, from the monitoring system, the measured at least one parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and (e) adjust the administration of the exogenous agent plan based at least in part on the measured parameter value in step (d). an ultrasound transducer; an administration device for administering an exogenous agent; a monitoring system for measuring at least one parameter value associated with at least one of (i) the ultrasound transducer, or (ii) the exogenous agent, wherein the monitoring system is further configured to measure a physiological parameter value associated with the target tissue or non-target tissue; wherein the monitoring system comprises a biosensor, wherein the physiological parameter value comprises at least one of a blood pressure, a blood circulation rate, a blood perfusion rate, a blood oxygen level or a heart rate; and at least one controller configured to: (a) generate a treatment plan based at least in part on the measured at least one parameter value; (b) cause administration of the exogenous agent; (c) cause the ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; (d) receive, from the monitoring system, the measured at least one parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and (e) adjust the administration of the exogenous agent plan based at least in part on the measured parameter value in step (d). (a) generate a treatment plan based at least in part on the measured at least one parameter value; (b) cause administration of the exogenous agent; (c) cause the ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent; (d) receive, from the monitoring system, the measured at least one parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment; and (e) adjust the administration of the exogenous agent plan based at least in part on the measured parameter value in step (d). <EOS>