Method for the fabrication of biodegradable polymeric thin films comprising the following preparation steps: a) selecting biodegradable polymers (BP) based on their in vivo degradation rates, monomers ratio, molecular weight, weight ratio and polymer blend ratio; b) spin coating the selected polymers (drug-loaded or drug-free) onto cleaned inorganic or organic substrates ; wherein nanopores are provided with tailored characteristics in multi-layers (1-3) or single layer blends , forming a delivery nanoplatform wherein it is specified to achieve a controlled and steady release of its payload; c) in that a biodegradable polymers (BP) solution is made from said biodegradable polymers (BP) which is spin coated and then left overnight to slow dry, wherein the increase in the spinning speed leads to an increase in the pore diameter and a decrease in the pore density and the decrease in the polymer concentrations keeping constant the rotation speed and spinning time, results in an increase in pore diameter, pore density of the engineered thin films; d) then preparing an organic solution containing an active drug and biodegradable polymers (BP) at different ratios, well dissolved in organic solvent, in respect to the desirable drug concentration for each medical need; e) spin coating the solution derived from said step (d) onto the said biodegradable polymeric layers and sterilizing, and f) determining nanopores characteristics (size, diameter and volume, density), including thickness, drug concentration and total drug quantity for delivery and release, optical properties, and quality of said biodegradable polymeric thin films ensuring the quality control of the drug loaded materials and independently of the complexity of the nanoplatform , wherein said steps are carried out in the specified order, characterized in that a polymer blend rate of PCL:PLGA is included, wherein said polymer blend rate of PCL:PLGA is ranging from 25:75 to 5:95 in weight ratio. a) selecting biodegradable polymers (BP) based on their in vivo degradation rates, monomers ratio, molecular weight, weight ratio and polymer blend ratio; b) spin coating the selected polymers (drug-loaded or drug-free) onto cleaned inorganic or organic substrates ; wherein nanopores are provided with tailored characteristics in multi-layers (1-3) or single layer blends , forming a delivery nanoplatform wherein it is specified to achieve a controlled and steady release of its payload; c) in that a biodegradable polymers (BP) solution is made from said biodegradable polymers (BP) which is spin coated and then left overnight to slow dry, wherein the increase in the spinning speed leads to an increase in the pore diameter and a decrease in the pore density and the decrease in the polymer concentrations keeping constant the rotation speed and spinning time, results in an increase in pore diameter, pore density of the engineered thin films; d) then preparing an organic solution containing an active drug and biodegradable polymers (BP) at different ratios, well dissolved in organic solvent, in respect to the desirable drug concentration for each medical need; e) spin coating the solution derived from said step (d) onto the said biodegradable polymeric layers and sterilizing, and f) determining nanopores characteristics (size, diameter and volume, density), including thickness, drug concentration and total drug quantity for delivery and release, optical properties, and quality of said biodegradable polymeric thin films ensuring the quality control of the drug loaded materials and independently of the complexity of the nanoplatform , wherein said steps are carried out in the specified order, characterized in that a polymer blend rate of PCL:PLGA is included, wherein said polymer blend rate of PCL:PLGA is ranging from 25:75 to 5:95 in weight ratio. <EOS>