An apparatus configured to measure luminescence from a multi-well plate, the multi-well plate having a plurality of wells comprising a plate top and a plate bottom , the plate bottom defining the bottom of said plurality of wells and comprising a substrate having: (x) a top surface including at least four electrodes , at least a portion of each one of said at least four electrodes being exposed within a well of said plurality of wells , wherein said at least four electrodes comprises at least two working electrodes and at least two counter electrodes , wherein each counter electrode is associated with a corresponding working electrode , and wherein at least a portion of one working electrode and a corresponding counter electrode is exposed within each well of said plurality of wells ; (y) a bottom surface comprising two or more electrical contact surfaces , wherein said bottom surface comprises a first electrical contact surface associated with said at least two working electrodes and a second electrical contact surface associated with said at least two counter electrodes ; and (z) four or more conductive through-holes electrically connecting said two or more electrical contact surfaces with said at least four electrodes ; and (zz) a plurality of independent electrode sectors, a sector comprising (i) at least one pair of working and associated counter electrodes on said top surface, and (ii) at least two electrical contact surfaces on said bottom surface; said apparatus comprising a photodetector for measuring emitted luminescence from at least a portion of the plurality of wells , an optical system , a plate transport mechanism , a plate electrical connector mechanism adapted to make and break contact with said two or more contact surfaces in one of said plurality of independent electrode sectors of said multi-well plate, and a plate alignment mechanism configured to align one or more of said plurality of independent electrode sectors with said optical system and said plate electrical connector mechanism . (x) a top surface including at least four electrodes , at least a portion of each one of said at least four electrodes being exposed within a well of said plurality of wells , wherein said at least four electrodes comprises at least two working electrodes and at least two counter electrodes , wherein each counter electrode is associated with a corresponding working electrode , and wherein at least a portion of one working electrode and a corresponding counter electrode is exposed within each well of said plurality of wells ; (y) a bottom surface comprising two or more electrical contact surfaces , wherein said bottom surface comprises a first electrical contact surface associated with said at least two working electrodes and a second electrical contact surface associated with said at least two counter electrodes ; and (z) four or more conductive through-holes electrically connecting said two or more electrical contact surfaces with said at least four electrodes ; and (zz) a plurality of independent electrode sectors, a sector comprising (i) at least one pair of working and associated counter electrodes on said top surface, and (ii) at least two electrical contact surfaces on said bottom surface; said apparatus comprising a photodetector for measuring emitted luminescence from at least a portion of the plurality of wells , an optical system , a plate transport mechanism , a plate electrical connector mechanism adapted to make and break contact with said two or more contact surfaces in one of said plurality of independent electrode sectors of said multi-well plate, and a plate alignment mechanism configured to align one or more of said plurality of independent electrode sectors with said optical system and said plate electrical connector mechanism . <EOS>