A compound having the following structure (I): or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein: X is -O-, -S(O) 0-2 -, -C(=O)-, -C(OR 5 ) 2 -, -C(OR 5 )(OC(=O)R 13 )-, -C(R 8 R 9 )-, -C(=CR 8 R 9 )-, -N(R 9 )-, -N(COR 9 )-, -CHNR 8 R 9 -, -C(=NR 9 )-, -C(=NOR 5 )-, or -C(=N-NHR 5 )-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13 ; R 3 is 5-6 membered heteroaryl or 3-7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl comprises at least one N atom in the ring and wherein said heteroaryl or said heterocyclyl are optionally substituted with one or more R 6 ; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 6 is each independently selected from the group consisting of H, F, CI, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl, wherein each R 6 is optionally substituted with one or more of halogen, 123 I, 18 F, hydroxyl, -OS(O) 2 -aryl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S(O) 0-2 R 5 , C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5 , or R 8 and R 9 can join to form a unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a , R 11b , R 11c and R 11d are each independently H, F, CI, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; -OR 5 , -OC(=O)R 13 , C 1 -C 10 acyl, -S(O) 0-2 R 5 , -NO 2 , -CN, -NH 2 , -NHR 5 , or -N(R 5 ) 2 ; R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; and n 3 is 0, 1, 2, 3, 4, or 5; wherein at least one of R 11a , R 11b , R 11c and R 11d is CI, Br, I or 123 I. X is -O-, -S(O) 0-2 -, -C(=O)-, -C(OR 5 ) 2 -, -C(OR 5 )(OC(=O)R 13 )-, -C(R 8 R 9 )-, -C(=CR 8 R 9 )-, -N(R 9 )-, -N(COR 9 )-, -CHNR 8 R 9 -, -C(=NR 9 )-, -C(=NOR 5 )-, or -C(=N-NHR 5 )-; R 1 and R 2 are each independently H, hydroxyl, -O-heterocyclyl, or -OC(=O)R 13 ; R 3 is 5-6 membered heteroaryl or 3-7 membered heterocyclyl, wherein said heteroaryl or said heterocyclyl comprises at least one N atom in the ring and wherein said heteroaryl or said heterocyclyl are optionally substituted with one or more R 6 ; R 5 is each independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 6 is each independently selected from the group consisting of H, F, CI, Br, I, 123 I, hydroxyl, oxo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkoxy, C 6 -C 12 aryl, wherein each R 6 is optionally substituted with one or more of halogen, 123 I, 18 F, hydroxyl, -OS(O) 2 -aryl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; R 8 and R 9 are each independently H, halogen, -S(O) 0-2 R 5 , C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, aralkyl, C 1 -C 10 acyl, or -NR 5 R 5 , or R 8 and R 9 can join to form a unsubstituted or substituted mono-, bi-, or tri-cyclic carbocycle or heterocycle containing from 3 to 20 carbon atoms; R 11a , R 11b , R 11c and R 11d are each independently H, F, CI, Br, I, 123 I, hydroxyl, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; -OR 5 , -OC(=O)R 13 , C 1 -C 10 acyl, -S(O) 0-2 R 5 , -NO 2 , -CN, -NH 2 , -NHR 5 , or -N(R 5 ) 2 ; R 13 is each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl; n 1 and n 2 are each independently 0, 1, or 2; and n 3 is 0, 1, 2, 3, 4, or 5; wherein at least one of R 11a , R 11b , R 11c and R 11d is CI, Br, I or 123 I. <EOS>