mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of formula (IIA) or an N -oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein E represents -CH 2 -; Q represents -CH(OH)-; Z represents pyridinyl; R 11 represents hydrogen or halogen; R 12 represents hydrogen, fluoro, chloro, trifluoromethyl, methyl or ethoxycarbonylethyl; R 15 represents hydrogen, fluoro, chloro, methyl,, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy; and R 16 represents hydrogen, halogen, cyano, C 1-6 alkyl, trifluoromethyl, difluoromethoxy or amino. E represents -CH 2 -; Q represents -CH(OH)-; Z represents pyridinyl; R 11 represents hydrogen or halogen; R 12 represents hydrogen, fluoro, chloro, trifluoromethyl, methyl or ethoxycarbonylethyl; R 15 represents hydrogen, fluoro, chloro, methyl,, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy; and R 16 represents hydrogen, halogen, cyano, C 1-6 alkyl, trifluoromethyl, difluoromethoxy or amino.
A surgical clip cartridge, comprising: a surgical clip ; a base portion and a plurality of dividers extending from the base portion, wherein the base portion extends in a longitudinal direction, the base portion having a bottom surface ; and the plurality of dividers extends from the base portion in a direction opposite of the bottom surface; wherein the base portion defines a mounting groove for attaching the base portion onto a surgical instrument shaft, characterised in that the mounting groove defines at least two docking portions , a first docking portion of the at least two docking portions being defined on a proximal end of the base portion in the longitudinal direction, and a second docking portion of the at least two docking portions being defined on a distal end of the base portion in the longitudinal direction, and wherein the first docking portion and the second docking portion both extend along a common longitudinal axis, each of the first and second docking portions defines a concave surface configured to snap on to, engage and conform around the surgical instrument shaft, and the concave surfaces extend between about 180° and about 270° around the longitudinal axis of the first and second docking portions . a surgical clip ; a base portion and a plurality of dividers extending from the base portion, wherein the base portion extends in a longitudinal direction, the base portion having a bottom surface ; and the plurality of dividers extends from the base portion in a direction opposite of the bottom surface; wherein the base portion defines a mounting groove for attaching the base portion onto a surgical instrument shaft, characterised in that the mounting groove defines at least two docking portions , a first docking portion of the at least two docking portions being defined on a proximal end of the base portion in the longitudinal direction, and a second docking portion of the at least two docking portions being defined on a distal end of the base portion in the longitudinal direction, and wherein the first docking portion and the second docking portion both extend along a common longitudinal axis, each of the first and second docking portions defines a concave surface configured to snap on to, engage and conform around the surgical instrument shaft, and the concave surfaces extend between about 180° and about 270° around the longitudinal axis of the first and second docking portions .
An actuator assembly comprising: an assembly housing having a cylindrical housing having opposing first and second ends and a hollow interior preferably containing a hydraulic fluid; a movable piston assembly disposed within the interior , the piston assembly including a piston rod supporting a piston head , the piston head having a fixed orifice and a check valve disposed in another orifice ; and a spring means disposed in relation to the piston head , characterized that the spring means includes at least one spring at the distal end of the piston rod and distal of the piston head , being preloaded in compression to create energy storage at the end of an extension stroke of the piston rod outward of the assembly housing . an assembly housing having a cylindrical housing having opposing first and second ends and a hollow interior preferably containing a hydraulic fluid; a movable piston assembly disposed within the interior , the piston assembly including a piston rod supporting a piston head , the piston head having a fixed orifice and a check valve disposed in another orifice ; and a spring means disposed in relation to the piston head , characterized that the spring means includes at least one spring at the distal end of the piston rod and distal of the piston head , being preloaded in compression to create energy storage at the end of an extension stroke of the piston rod outward of the assembly housing .
Apparatus for the production of dry ice pellets comprising a plurality of press chambers with movable pistons for compressing carbon dioxide in solid phase and for pressing the solid carbon dioxide through a hole plate provided at the end of each press chamber, characterized in that the press chambers of the apparatus are arranged at a distance around a central axis, wherein each of the press chambers is provided with its own piston and with an axis of motion, along which the piston reciprocates, and wherein the apparatus comprises a common drive arranged to actuate the pistons alternately one by one in a rotary direction around the central axis.
A method for controlling the electrical drive chain of a vehicle, said drive chain comprising: - polyphase electrical machine , in particular a rotating polyphase electrical machine, comprising a stator electrical winding having a plurality of coils each forming an electrical phase of the stator, - a self-contained electrical energy source supplying the stator electrical winding of the machine , and - a switching system interposed between the self-contained electrical energy source and the stator electrical winding and comprising a plurality of switching cells , method in which: - a command is applied to the switching system to operate the electrical drive chain according to a predefined mode, - a deviation between the real operating mode of the drive chain and the predefined operating mode is detected, characterised in that - an auxiliary command is applied to the switching system , said auxiliary command short-circuiting only part of the coils of the stator electrical winding such that the voltage (e) across each non-short-circuited coil is lower than a given threshold value. - polyphase electrical machine , in particular a rotating polyphase electrical machine, comprising a stator electrical winding having a plurality of coils each forming an electrical phase of the stator, - a self-contained electrical energy source supplying the stator electrical winding of the machine , and - a switching system interposed between the self-contained electrical energy source and the stator electrical winding and comprising a plurality of switching cells , - a command is applied to the switching system to operate the electrical drive chain according to a predefined mode, - a deviation between the real operating mode of the drive chain and the predefined operating mode is detected, characterised in that - an auxiliary command is applied to the switching system , said auxiliary command short-circuiting only part of the coils of the stator electrical winding such that the voltage (e) across each non-short-circuited coil is lower than a given threshold value.
A connector comprising: a first housing ; a second housing that is fitted into the first housing along a first direction (X); a sensing member that is inserted into the second housing along the first direction (X); and a sensing mechanism that allows the sensing member to advance to a predetermined engaged position along the first direction (X) when the first housing and the second housing are completely fitted, and locking the sensing member at a position before the engaged position when the first housing and the second housing are not completely fitted, wherein the sensing member includes an exposed portion positioned in an end portion of the sensing member and exposed to an outer space when the sensing member is in the engaged position, and in the exposed portion , a first surface exposed to a side opposite to a side of a central axis (CL) of the second housing is an inclined surface or an arc-shaped surface extending in a direction inclined with respect to the first direction (X) and facing a side opposite to a side of the first housing in the first direction (X), and the sensing member includes a recessed portion into which a jig to extract the sensing member can be inserted, characterised in that the recessed portion is opened to the first surface . a first housing ; a second housing that is fitted into the first housing along a first direction (X); a sensing member that is inserted into the second housing along the first direction (X); and a sensing mechanism that allows the sensing member to advance to a predetermined engaged position along the first direction (X) when the first housing and the second housing are completely fitted, and locking the sensing member at a position before the engaged position when the first housing and the second housing are not completely fitted, wherein the sensing member includes an exposed portion positioned in an end portion of the sensing member and exposed to an outer space when the sensing member is in the engaged position, and in the exposed portion , a first surface exposed to a side opposite to a side of a central axis (CL) of the second housing is an inclined surface or an arc-shaped surface extending in a direction inclined with respect to the first direction (X) and facing a side opposite to a side of the first housing in the first direction (X), and the sensing member includes a recessed portion into which a jig to extract the sensing member can be inserted, characterised in that the recessed portion is opened to the first surface .
Down-holder for holding down a coupling socket of a vehicle coupling on a coupling ball of the vehicle coupling, wherein the down-holder has a down-holder main body with a threaded bore , wherein an adjustment screw is arranged in the threaded bore , wherein the adjustment screw has a contact surface for contacting the coupling socket, wherein the down-holder has a clamping device for clamping the adjustment screw in the threaded bore , wherein the clamping device is arranged laterally relative to the threaded bore , characterized in that the threaded bore has at least one lateral slot , in that the slot separates two regions of the down-holder main body from one another, and in that the clamping device is designed to press the two regions of the down-holder main body separated by the slot together in a predefinable manner.
A method of operating an engine assembly, the engine assembly comprising an exhaust gas recirculation system having a valve for controlling the flow of exhaust gases through the exhaust gas recirculation system, the method comprising: determining that the engine should be shut down; determining a likelihood of the formation of condensation within cylinders of the engine assembly after the engine has been shut down; selecting an engine shut down procedure based on the likelihood of formation of condensation, wherein if it is determined that the likelihood of condensation is above a first threshold value, the selected engine shut down procedure comprises: a) closing the valve of the exhaust gas recirculation system; b) maintaining an inlet throttle of the engine assembly in an open position for a period of time; c) cutting the supply of fuel to the engine following the period of time whilst the inlet throttle is in the open position; and if it is determined that the likelihood of condensation is below a second threshold value, the engine shut down procedure is selected in order to minimise vibrations of the engine during the engine shut down; and performing the engine shut down procedure to shut down the engine. determining that the engine should be shut down; determining a likelihood of the formation of condensation within cylinders of the engine assembly after the engine has been shut down; selecting an engine shut down procedure based on the likelihood of formation of condensation, wherein if it is determined that the likelihood of condensation is above a first threshold value, the selected engine shut down procedure comprises: a) closing the valve of the exhaust gas recirculation system; b) maintaining an inlet throttle of the engine assembly in an open position for a period of time; c) cutting the supply of fuel to the engine following the period of time whilst the inlet throttle is in the open position; and a) closing the valve of the exhaust gas recirculation system; b) maintaining an inlet throttle of the engine assembly in an open position for a period of time; c) cutting the supply of fuel to the engine following the period of time whilst the inlet throttle is in the open position; and if it is determined that the likelihood of condensation is below a second threshold value, the engine shut down procedure is selected in order to minimise vibrations of the engine during the engine shut down; and performing the engine shut down procedure to shut down the engine.
Organic electroluminescent device comprising, in the light-emitting layer, at least one organic compound of the formulae (89-1) and/or (89-2), where the following applies to the symbols and indices used: R 1 is, identically or differently on each occurrence, H, F, CN, CF 3 , CHF 2 or an alkyl, alkoxy or alkylalkoxy group having 1 to 15 C atoms; with the proviso that more than one of the radicals R 1 in the compound of the formulae (89-1) and/or (89-2) are equal to F. R 1 is, identically or differently on each occurrence, H, F, CN, CF 3 , CHF 2 or an alkyl, alkoxy or alkylalkoxy group having 1 to 15 C atoms;
A kit for measuring a size of a gingival space and selecting an appropriate shaped dental matrix, the kit comprising: (i) a measuring gauge comprising: a handle section ; and a distal end section connected to the handle section , the distal end section including graduated sections with different widths, wherein the gauge includes a different indicia associated with each of the widths; and (ii) a plurality of dental matrices, each of the dental matrices comprising a curved strip of material, the strip having a length from a first end to a second end sufficient to create a form for molding a restorative material to a surface of a tooth being restored, wherein a first of the dental matrices has a first matrix indicia corresponding to one of the different indicia of the gauge , and wherein a second of the dental matrices has a second matrix indicia corresponding to another of the different indicia of the gauge . (i) a measuring gauge comprising: a handle section ; and a distal end section connected to the handle section , the distal end section including graduated sections with different widths, wherein the gauge includes a different indicia associated with each of the widths; and a handle section ; and a distal end section connected to the handle section , the distal end section including graduated sections with different widths, wherein the gauge includes a different indicia associated with each of the widths; and (ii) a plurality of dental matrices, each of the dental matrices comprising a curved strip of material, the strip having a length from a first end to a second end sufficient to create a form for molding a restorative material to a surface of a tooth being restored, wherein a first of the dental matrices has a first matrix indicia corresponding to one of the different indicia of the gauge , and wherein a second of the dental matrices has a second matrix indicia corresponding to another of the different indicia of the gauge . wherein a first of the dental matrices has a first matrix indicia corresponding to one of the different indicia of the gauge , and wherein a second of the dental matrices has a second matrix indicia corresponding to another of the different indicia of the gauge .
A composition for use in treating or delaying progression of a HER2-positive cancer in an individual, characterized in that cancer cells in the individual express PD-L1, and that said composition is selected from the group consisting of: (a) a composition comprising a human anti-PD-Ll antibody or antigen binding fragment thereof and an optional pharmaceutically acceptable carrier, wherein said anti-PD-Ll antibody inhibits the binding of PD-L1 to both PD-1 and B7-1, wherein said treatment of cancer or said delaying progression of cancer comprises administration of said composition in combination with a second composition, wherein the second composition comprises an anti-HER2 antibody and an optional pharmaceutically acceptable carrier, and wherein the anti-HER2 antibody is a bispecific antibody that comprises a first antigen binding domain that binds to HER2, and a second antigen binding domain that binds to CD3; and (b) a composition comprising an anti-HER2 antibody and an optional pharmaceutically acceptable carrier, wherein said treatment of cancer or said delaying progression of cancer comprises administration of said composition in combination with a second composition, wherein the second composition comprises a human anti-PD-Ll antibody or antigen binding fragment thereof and an optional pharmaceutically acceptable carrier, wherein said anti-PD-Ll antibody inhibits the binding of PD-L1 to both PD-1 and B7-1, and wherein the anti-HER2 antibody is a bispecific antibody that comprises a first antigen binding domain that binds to HER2, and a second antigen binding domain that binds to CD3. (a) a composition comprising a human anti-PD-Ll antibody or antigen binding fragment thereof and an optional pharmaceutically acceptable carrier, wherein said anti-PD-Ll antibody inhibits the binding of PD-L1 to both PD-1 and B7-1, wherein said treatment of cancer or said delaying progression of cancer comprises administration of said composition in combination with a second composition, wherein the second composition comprises an anti-HER2 antibody and an optional pharmaceutically acceptable carrier, and wherein the anti-HER2 antibody is a bispecific antibody that comprises a first antigen binding domain that binds to HER2, and a second antigen binding domain that binds to CD3; and (b) a composition comprising an anti-HER2 antibody and an optional pharmaceutically acceptable carrier, wherein said treatment of cancer or said delaying progression of cancer comprises administration of said composition in combination with a second composition, wherein the second composition comprises a human anti-PD-Ll antibody or antigen binding fragment thereof and an optional pharmaceutically acceptable carrier, wherein said anti-PD-Ll antibody inhibits the binding of PD-L1 to both PD-1 and B7-1, and wherein the anti-HER2 antibody is a bispecific antibody that comprises a first antigen binding domain that binds to HER2, and a second antigen binding domain that binds to CD3.
A fuel cell system for use onboard an aircraft, comprising: a fuel tank that is a source of fuel; a fuel desulfurization system fluidly coupled to the fuel tank to receive the fuel in a liquid phase, the fuel desulfurization system including a vacuum system that depressurizes the fuel to convert at least a portion of the fuel from the liquid phase to a gaseous phase without an external heat source, the vacuum system including a vacuum tank that receives the fuel in the liquid phase from the fuel tank and a vacuum blower that applies a negative pressure to the vacuum tank to convert the portion of the fuel from the liquid phase to the gaseous phase, the vacuum blower directing a flow of fuel in the gaseous phase from the tank to a reformer via a first conduit ; a reformer fluidly coupled to the fuel desulfurization system via the first conduit to receive the fuel in the gaseous phase from the fuel desulfurization system , and to generate a hydrogen enriched fuel in the gaseous phase; and a fuel cell stack fluidly coupled to the reformer via a second conduit to receive fuel from the fuel desulfurization system in the gaseous phase. a fuel tank that is a source of fuel; a fuel desulfurization system fluidly coupled to the fuel tank to receive the fuel in a liquid phase, the fuel desulfurization system including a vacuum system that depressurizes the fuel to convert at least a portion of the fuel from the liquid phase to a gaseous phase without an external heat source, the vacuum system including a vacuum tank that receives the fuel in the liquid phase from the fuel tank and a vacuum blower that applies a negative pressure to the vacuum tank to convert the portion of the fuel from the liquid phase to the gaseous phase, the vacuum blower directing a flow of fuel in the gaseous phase from the tank to a reformer via a first conduit ; a reformer fluidly coupled to the fuel desulfurization system via the first conduit to receive the fuel in the gaseous phase from the fuel desulfurization system , and to generate a hydrogen enriched fuel in the gaseous phase; and a fuel cell stack fluidly coupled to the reformer via a second conduit to receive fuel from the fuel desulfurization system in the gaseous phase.
A laser arrangement comprising a laser array and an optical device for providing a defined illumination pattern in a defined field-of-view, wherein the optical device comprises a multitude of localized optical structures , wherein each localized optical structure is associated with at least one laser , and wherein each localized optical structure is arranged to redirect laser light emitted by at least one laser comprised by the laser array such that the laser light emitted by each laser appears to be emitted from at least one apparent position (130-1a, 130-1b) of the laser array , wherein the optical device is arranged such that the apparent positions (130-1a, 130-1b) are distributed in an irregular pattern, characterized in that the localized optical structures are arranged such that the laser light emitted by at least one of the lasers appears to be emitted from at least two apparent positions of the laser array.