A flow cell , comprising: a plurality of inlet ports , each inlet port of the plurality of inlet ports (120-130) sized to receive a flow of reagent from a corresponding reagent of a plurality of reagents into the flow cell ; characterized in that an outlet port sized to pass a flow of reagent out of the flow cell ; and a flow channel positioned between, and in fluid communication with, each inlet port of the plurality of inlet ports (120-130) and the outlet port , the flow channel comprising: a manifold section having a plurality of manifold branches in fluid communication with a common line , each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports (120-130), and a detection section in fluid communication with the common line and the outlet port , the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times smaller than a swept volume of the detection section, wherein the swept volume is defined as the total internal volume of the flow channel of the flow cell . a plurality of inlet ports , each inlet port of the plurality of inlet ports (120-130) sized to receive a flow of reagent from a corresponding reagent of a plurality of reagents into the flow cell ; characterized in that an outlet port sized to pass a flow of reagent out of the flow cell ; and a flow channel positioned between, and in fluid communication with, each inlet port of the plurality of inlet ports (120-130) and the outlet port , the flow channel comprising: a manifold section having a plurality of manifold branches in fluid communication with a common line , each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports (120-130), and a detection section in fluid communication with the common line and the outlet port , the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times a manifold section having a plurality of manifold branches in fluid communication with a common line , each manifold branch of the plurality of manifold branches connected to a corresponding inlet port of the plurality of inlet ports (120-130), and a detection section in fluid communication with the common line and the outlet port , the detection section operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section; wherein the plurality of branches of the manifold section have a first height and the detection section has a second height, wherein the first height is less than the second height; and wherein the manifold section has a swept volume that is at least about 10 times smaller than a swept volume of the detection section, wherein the swept volume is defined as the total internal volume of the flow channel of the flow cell . <EOS>