A method for optimizing a liquid class for a laboratory automation device , wherein the liquid class comprises control parameters for controlling the laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class , the method comprising: initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class ; optimizing the liquid class iteratively with the genetic algorithm by: applying liquid classes from the set of liquid classes to the laboratory automation device , which performs at least one aspiration and dispensing measurement for each applied liquid class , wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class , indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes. initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class ; optimizing the liquid class iteratively with the genetic algorithm by: applying liquid classes from the set of liquid classes to the laboratory automation device , which performs at least one aspiration and dispensing measurement for each applied liquid class , wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class , indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes. applying liquid classes from the set of liquid classes to the laboratory automation device , which performs at least one aspiration and dispensing measurement for each applied liquid class , wherein during an aspiration and dispensing measurement, the laboratory automation device is controlled with the control parameters of the respective applied liquid class and a dispensed volume of a liquid of the liquid type is measured; discarding liquid classes from the set of liquid classes, when a selection function, which evaluates the at least one measured dispense volume for a liquid class , indicates this; adding liquid classes to the set of liquid classes, which are generated by modifying liquid classes from the set of liquid classes; in the end, selecting an optimized liquid class from the set of liquid classes. <EOS>