mhurhangee/patent-ind-claim-en huggingface dataset:
A microscope for imaging at least one stationary sample , the microscope comprising: - an objective lens movable with respect to the at least one stationary sample ; - a plurality of individual light sources for illuminating the at least one stationary sample ; and - a detector for detection of radiation from the at least one stationary sample ; - an optical arrangement arranged such that a light path from at least one of the plurality of individual light sources illuminates the at least one stationary sample through the objective lens and directs the radiation from the at least one stationary sample to the detector through the objective lens ; - an immovable sample holder for mounting the at least one stationary sample , and - a translation stage , on which the plurality of individual light sources , the optical arrangement, and the detector are mounted, the translation stage being movable in two dimensions relative to the sample , wherein the plurality of individual light sources is movable with respect to the translation stage and with respect to the objective lens such that different ones of the plurality of individual light sources illuminate the stationary sample . - an objective lens movable with respect to the at least one stationary sample ; - a plurality of individual light sources for illuminating the at least one stationary sample ; and - a detector for detection of radiation from the at least one stationary sample ; - an optical arrangement arranged such that a light path from at least one of the plurality of individual light sources illuminates the at least one stationary sample through the objective lens and directs the radiation from the at least one stationary sample to the detector through the objective lens ; - an immovable sample holder for mounting the at least one stationary sample , and - a translation stage , on which the plurality of individual light sources , the optical arrangement, and the detector are mounted, the translation stage being movable in two dimensions relative to the sample ,
A human natural killer (NK) cell or NK cell line for use in treating cancer, wherein the NK cell or NK cell line has been genetically modified to knock out or knock down expression of a checkpoint inhibitory receptor selected from CD96 (TACTILE) and CD328 (SIGLEC7).
A method for introducing substituents into a carbon at an α-position and a carbon at a β-position of an α,β-unsaturated ketone, comprising: a first step of mixing alkyllithium and trialkylalkenyl tin in which tin binds to the vinyl position of the alkenyl group; a second step of mixing the mixture of the first step and dialkylzinc; a third step of mixing the mixture of the second step and an α,β-unsaturated ketone; and a fourth step of mixing the mixture of the third step and a trifluoromethanesulfonate compound. a first step of mixing alkyllithium and trialkylalkenyl tin in which tin binds to the vinyl position of the alkenyl group; a second step of mixing the mixture of the first step and dialkylzinc; a third step of mixing the mixture of the second step and an α,β-unsaturated ketone; and a fourth step of mixing the mixture of the third step and a trifluoromethanesulfonate compound.
A separation method for amine, the separation method comprising: performing liquid chromatography, wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on and chemically bound to a carrier is used as a stationary phase, wherein a mobile phase comprises an aqueous solution of at least one salt of a hydrophobic anion selected from a salt of a chaotropic anion, characterized in that no perchloric acid is added to the mobile phase. wherein a separating agent in which a ligand having a crown ether-like cyclic structure is supported on and chemically bound to a carrier is used as a stationary phase, wherein a mobile phase comprises an aqueous solution of at least one salt of a hydrophobic anion selected from a salt of a chaotropic anion, characterized in that no perchloric acid is added to the mobile phase.
An energy device for surgical operation having an operational area portion for transmitting energy to a body target portion, characterized in that a coating layer formed on an outer periphery of a base material constituting the operational area portion is comprised of a base coating having a thickness of 0.1-1.0 μm formed on the base material and an outermost coating having a thickness of 0.1 μm formed on the base coating , the base coating is silicon oxide or a mixture containing silicon oxide, while the outermost coating is polysiloxane or a compound containing polysiloxane or a compound containing a partly fluorinated polysiloxane, and wherein a surface roughness of the base material is 0.01-1.0 μm as Ra value before the formation of the coating layer .
A machine-implemented method for advertising a service in a peer-to-peer networking environment, the method comprising: monitoring operating conditions of a local device coupled to a wireless network; dynamically adjusting an advertisement period based on the operating conditions of the local device, wherein the advertisement period of the local device comprises an interval time between successive transmissions of an advertisement by the local device, and wherein the advertisement period of the local device and an advertisement period of a remote device are multiples of a same predetermined base value and are not equal to each other; and broadcasting , by the local device, a service advertisement in the wireless network according to the adjusted advertisement period, the service advertisement including one or more service identifiers for identifying one or more services to be advertised from the local device. monitoring operating conditions of a local device coupled to a wireless network; dynamically adjusting an advertisement period based on the operating conditions of the local device, wherein the advertisement period of the local device comprises an interval time between successive transmissions of an advertisement by the local device, and wherein the advertisement period of the local device and an advertisement period of a remote device are multiples of a same predetermined base value and are not equal to each other; and broadcasting , by the local device, a service advertisement in the wireless network according to the adjusted advertisement period, the service advertisement including one or more service identifiers for identifying one or more services to be advertised from the local device.
A multi-tissue body-on-a-chip apparatus, comprising: a first chamber comprising a first organoid; a second chamber comprising a second organoid; a primary fluid conduit that connects said first and second chambers; and a common aqueous growth media in said first chamber, said second chamber, and said primary fluid conduit; wherein said first and second chambers are connected in series and are in fluid communication with one another via said primary fluid conduit; wherein, in operation, the media flows through said first chamber, said second chamber, and said primary fluid conduit by recirculating perfusion; wherein said first and second organoids are different from each other, wherein the volume of the apparatus is less than 100 μL, wherein each of said first chamber and said second chamber has a volume in a range of 2 μL to 10 μL, and wherein the apparatus provides a hyperphysiological fluid to tissue volume ratio. a first chamber comprising a first organoid; a second chamber comprising a second organoid; a primary fluid conduit that connects said first and second chambers; and a common aqueous growth media in said first chamber, said second chamber, and said primary fluid conduit; wherein said first and second chambers are connected in series and are in fluid communication with one another via said primary fluid conduit; wherein, in operation, the media flows through said first chamber, said second chamber, and said primary fluid conduit by recirculating perfusion; wherein said first and second organoids are different from each other, wherein the volume of the apparatus is less than 100 μL, wherein each of said first chamber and said second chamber has a volume in a range of 2 μL to 10 μL, and wherein the apparatus provides a hyperphysiological fluid to tissue volume ratio.
A woven papermaking fabric having a machine direction axis and a cross-machine direction axis, the fabric comprising: a plurality of machine direction (MD) oriented warp filaments and a plurality of substantially cross-machine direction (CD) oriented shute filaments , the shute filaments being interwoven with warp filaments to provide a machine contacting fabric side and opposed web contacting fabric side , the web contacting fabric side having a plurality of protuberances disposed thereon, the plurality of protuberances each having: a length, a height, an upper surface that is substantially planar and lies in an upper surface plane , and a non-zero element angle ( α ), wherein the element angle ( α ) is the orientation of the protuberance relative to the machine direction axis , wherein the plurality of protuberances are spaced apart from one another to define a plurality of valleys there between, each of the plurality of protuberances having an adjacent valley having a valley bottom plane , wherein the distance between the protuberance upper surface plane and the valley bottom plane varies less than about 150 μm along the length of the protuberance , and wherein each of the plurality of protuberances has a valley wall angle greater than about 20 degrees, wherein the valley wall angle is the angle formed between a given valley bottom plane and an adjacent protuberance. the plurality of protuberances each having: a length, a height, an upper surface that is substantially planar and lies in an upper surface plane , and a non-zero element angle ( α ), wherein the element angle ( α ) is the orientation of the protuberance relative to the machine direction axis , a length, a height, an upper surface that is substantially planar and lies in an upper surface plane , and a non-zero element angle ( α ), wherein the element angle ( α ) is the orientation of the protuberance relative to the machine direction axis , wherein the plurality of protuberances are spaced apart from one another to define a plurality of valleys there between, each of the plurality of protuberances having an adjacent valley having a valley bottom plane , wherein the distance between the protuberance upper surface plane and the valley bottom plane varies less than about 150 μm along the length of the protuberance , and wherein each of the plurality of protuberances has a valley wall angle greater than about 20 degrees, wherein the valley wall angle is the angle formed between a given valley bottom plane and an adjacent protuberance.
A method for detecting an oligonucleotide and its oligonucleotide metabolites, wherein the oligonucleotide is a single stranded oligomer of either ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), comprising the steps of (a) selecting a biological sample containing or suspected of containing said oligonucleotide, wherein the sample is tissue lysate or plasma, (b) forming a hybridization mixture by contacting the biological sample with a fluorescently labeled peptide nucleic acid (PNA) probe which is fully complementary to at least 10 or more nucleotides of said oligonucleotide, (c) separating hybridized moieties formed between said oligonucleotide and said PNA probe from unhybridized moieties by anion exchange high performance liquid chromatography (HPLC), characterized in that excess non-hybridized PNA-probe elutes in the void volume of the HPLC, and (d) quantitatively detecting said hybridized moieties by fluorescence spectroscopy, further characterized in that oligonucleotide metabolite signals are separated from the signal generated by the intact oligonucleotide. (a) selecting a biological sample containing or suspected of containing said oligonucleotide, wherein the sample is tissue lysate or plasma, (b) forming a hybridization mixture by contacting the biological sample with a fluorescently labeled peptide nucleic acid (PNA) probe which is fully complementary to at least 10 or more nucleotides of said oligonucleotide, (c) separating hybridized moieties formed between said oligonucleotide and said PNA probe from unhybridized moieties by anion exchange high performance liquid chromatography (HPLC), characterized in that excess non-hybridized PNA-probe elutes in the void volume of the HPLC, and (d) quantitatively detecting said hybridized moieties by fluorescence spectroscopy,
A unit of packaged product, comprising a package with an inner cavity formed by a pocket portion containing a product (P) and communicating with an elongated portion in which a straw is housed, the straw having a proximal end leading into the pocket portion and a distal end closed by a cap portion of the package , the straw being completely inserted into the elongated portion , the outer wall of the straw being welded perimetrically to the package in a proximal sealing area at the proximal end of the straw so as to form a sealing ring that extends from the proximal end of the straw along a certain length, to prevent leakage of the product (P) from the pocket portion along the outer surface of the straw , characterized in that the package is formed by two opposing shells welded to each other along a continuous sealing incorporating the proximal sealing area .
A computer-implemented method for creating a surface related to a subsurface formation and having one or more faults, based on data comprising well tops and faults associated with the subsurface formation, the method comprising: a) estimating a surface level on each side of each fault , an elevation difference between the estimated surface levels on each side of a respective fault representing a respective fault throw value; b) adjusting each fault throw value; characterised in that the method further comprises: c) locating each local well top within a predefined search neighborhood from a grid node within a grid on the surface; d) identifying each fault that crosses a vector between the grid node and each respective local well top, each vector between the grid node and each respective local well top representing an intersecting vector; e) accumulating each adjusted fault throw value along each respective intersecting vector, which represents an accumulated fault throw value for each respective intersecting vector; f) adjusting a value for each local well top based on a respective accumulated fault throw value, the value for each local well top being adjusted by adding the value of each local well top to the respective accumulated fault throw value; g) performing interpolation at the grid node using the adjusted value for each local well top; and h) repeating steps c) - g) for each grid node within the grid, wherein the value for each local well top is adjusted by adding the value of each local well top to the respective accumulated fault throw value. a) estimating a surface level on each side of each fault , an elevation difference between the estimated surface levels on each side of a respective fault representing a respective fault throw value; b) adjusting each fault throw value; c) locating each local well top within a predefined search neighborhood from a grid node within a grid on the surface; d) identifying each fault that crosses a vector between the grid node and each respective local well top, each vector between the grid node and each respective local well top representing an intersecting vector; e) accumulating each adjusted fault throw value along each respective intersecting vector, which represents an accumulated fault throw value for each respective intersecting vector; f) adjusting a value for each local well top based on a respective accumulated fault throw value, the value for each local well top being adjusted by adding the value of each local well top to the respective accumulated fault throw value; g) performing interpolation at the grid node using the adjusted value for each local well top; and h) repeating steps c) - g) for each grid node within the grid,
A volumetric compensator assembly for use in the seal section of a pumping system , the volumetric compensator assembly comprising a bladder support tube and an envelope bladder that in turn comprises: a top sheet , wherein the top sheet is flexible; a bottom sheet , wherein the bottom sheet is connected to the top sheet along one or more seams ; and wherein the top sheet and bottom sheet together define a bladder interior that has a variable capacity; characterized in that the envelope bladder is coiled around the bladder support tube and wherein the envelope bladder further comprises a mouth and wherein the mouth is connected to the bladder support tube , with the bladder interior in fluid communication with an interior of the bladder support tube. a top sheet , wherein the top sheet is flexible; a bottom sheet , wherein the bottom sheet is connected to the top sheet along one or more seams ; and wherein the top sheet and bottom sheet together define a bladder interior that has a variable capacity; characterized in that the envelope bladder is coiled around the bladder support tube and wherein the envelope bladder further comprises a mouth and wherein the mouth is connected to the bladder support tube , with the bladder interior in fluid communication with an interior of the bladder support tube.
A wind turbine rotor blade comprising a rotor blade root region , a rotor blade tip region , a pressure side , a suction side , a leading edge , a trailing edge , at least one fin which extends along a longitudinal direction (L) of the rotor blade , at least one deflection unit between an end of the at least one fin and the rotor blade tip region , wherein the at least one first deflection unit is adapted to deflect an air flow which is propagated along the at least one fin , characterized by at least one fin drop-shaped portion arranged in the region of the at least one fin to reduce turbulence of the air upon deflection.
A system , comprising: a flexible intermediate transfer member (ITM) comprising a stack of at least (i) a first layer , located at an outer surface of the ITM and configured to receive ink droplets from an ink supply subsystem having multiple print bars arranged along an axis for applying, to the first layer, the ink droplets having multiple colors, respectively, to form an ink image on the first layer, and to transfer the ink image to a target substrate, and (ii) a second layer comprising a matrix that holds particles at respective given locations, wherein the second layer is configured to receive optical radiation passing through the first layer, and wherein the particles are configured to heat the ITM by absorbing at least part of the optical radiation; an illumination assembly , which is configured to dry the droplets of ink by directing the optical radiation to impinge on at least some of the particles, wherein the illumination assembly comprises an array of a plurality of light sources arranged along the axis and interleaved with the multiple print bars; and a temperature control assembly , which is configured to control a temperature of the ITM by directing a gas to the ITM, wherein the illumination assembly and the temperature control assembly are packaged together in a housing having at least a cavity facing the substrate and wherein at least a pair of light sources among the pairs of light sources is arranged within the cavity. a flexible intermediate transfer member (ITM) comprising a stack of at least (i) a first layer , located at an outer surface of the ITM and configured to receive ink droplets from an ink supply subsystem having multiple print bars arranged along an axis for applying, to the first layer, the ink droplets having multiple colors, respectively, to form an ink image on the first layer, and to transfer the ink image to a target substrate, and (ii) a second layer comprising a matrix that holds particles at respective given locations, wherein the second layer is configured to receive optical radiation passing through the first layer, and wherein the particles are configured to heat the ITM by absorbing at least part of the optical radiation; an illumination assembly , which is configured to dry the droplets of ink by directing the optical radiation to impinge on at least some of the particles, wherein the illumination assembly comprises an array of a plurality of light sources arranged along the axis and interleaved with the multiple print bars; and a temperature control assembly , which is configured to control a temperature of the ITM by directing a gas to the ITM, wherein the illumination assembly and the temperature control assembly are packaged together in a housing having at least a cavity facing the substrate and wherein at least a pair of light sources among the pairs of light sources is arranged within the cavity.
A method comprising: infiltrating a ceramic matrix composite (CMC) substrate with a first slurry, wherein the CMC substrate comprises a reinforcement material defining a plurality of pores and the first slurry at least partially fills some of the pores of the CMC substrate, and wherein the first slurry comprises a carrier material and first solid particles comprising a first ceramic material; drying the first slurry to form an infiltrated CMC comprising the first solid particles; depositing a second slurry comprising a carrier material and second solid particles on a surface of the infiltrated CMC, wherein the second solid particles comprise a plurality of fine ceramic particles defining a fine particle average size, a plurality of coarse ceramic particles defining a coarse particle average size, and a plurality of diamond particles, wherein the fine particle average size is less than the coarse particle average size; drying the second slurry to form an article having an outer surface layer comprising the second solid particles on the infiltrated CMC, wherein the first solid particles define a first solid content percent within the pores of the CMC substrate, and wherein the outer surface layer defines a second solid content percent greater than the first solid content percent; and infiltrating the article with a molten infiltrant to form a composite article. infiltrating a ceramic matrix composite (CMC) substrate with a first slurry, wherein the CMC substrate comprises a reinforcement material defining a plurality of pores and the first slurry at least partially fills some of the pores of the CMC substrate, and wherein the first slurry comprises a carrier material and first solid particles comprising a first ceramic material; drying the first slurry to form an infiltrated CMC comprising the first solid particles; depositing a second slurry comprising a carrier material and second solid particles on a surface of the infiltrated CMC, wherein the second solid particles comprise a plurality of fine ceramic particles defining a fine particle average size, a plurality of coarse ceramic particles defining a coarse particle average size, and a plurality of diamond particles, wherein the fine particle average size is less than the coarse particle average size; drying the second slurry to form an article having an outer surface layer comprising the second solid particles on the infiltrated CMC, wherein the first solid particles define a first solid content percent within the pores of the CMC substrate, and wherein the outer surface layer defines a second solid content percent greater than the first solid content percent; and infiltrating the article with a molten infiltrant to form a composite article.