A compound, having a formula or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein R 1 is selected from aryl, heteroaryl, heterocyclic, alkenyl, cycloalkyl, cycloalkenyl or polycyclic; R 2 is selected from alkyl, alkenyl, or cycloalkyl; Y is selected from N, N-O or C-R 3d ; R 3a , R 3b , R 3c and R 3d are each independently selected from hydrogen, deuterium, halide, alkyl, alkenyl, alkoxy, alkylthio, amino, sulfonyl, aminosulfonyl, aminocarbonyl, acyl, hydroxyl or nitro; R 4a is deuterium; R 4b is selected from hydrogen, deuterium, halide or alkyl; L 1 and L 2 are independently selected from hydrogen, deuterium, alkyl, cycloalkyl, or together form a pi-bond; and R 5a , R 5b , R 5c , R 5d and R 5e are each independently selected from hydrogen, deuterium, halide, alkyl, alkenyl, alkoxy, alkylthio, amino, sulfonyl, aminosulfonyl, aminocarbonyl, acyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, hydroxyl or nitro; or any two adjacent groups selected together form an aryl, heteroaryl, cycloalkyl or heterocyclic ring; and wherein none of R 5a , R 5b , R 5c , R 5d or R 5e are -R x -L x -R x2 , where R x is selected from O, NR x3 , sulfonyl or S; R x3 is selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or aryl; L x is selected from a bond, alkylene, alkenylene, alkynylene, cycloalkyl, cycloalkenyl, heterocyclic, aryl, heteroaryl or CR x4 R x5 ; R x4 and R x5 are each independently selected from H, D, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -C(O)OR x6 , or -C(O)NR x6 R x7 ; R x6 and R x7 are each independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl; R x2 is selected from -C(O)L x2 R x8 or a carboxyl bioisostere; L x2 is a bond or NR x3 ; R x8 is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -OR x9 , N(R x9 ) 2 , - C(O)R x9 , -S(O) 2 R x9 , -C(O)OR x9 , -S(O) 2 N(R x9 ) 2 or -C(O)N(R x9 ) 2 ; and each R x9 is independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl. R 1 is selected from aryl, heteroaryl, heterocyclic, alkenyl, cycloalkyl, cycloalkenyl or polycyclic; R 2 is selected from alkyl, alkenyl, or cycloalkyl; Y is selected from N, N-O or C-R 3d ; R 3a , R 3b , R 3c and R 3d are each independently selected from hydrogen, deuterium, halide, alkyl, alkenyl, alkoxy, alkylthio, amino, sulfonyl, aminosulfonyl, aminocarbonyl, acyl, hydroxyl or nitro; R 4a is deuterium; R 4b is selected from hydrogen, deuterium, halide or alkyl; L 1 and L 2 are independently selected from hydrogen, deuterium, alkyl, cycloalkyl, or together form a pi-bond; and R 5a , R 5b , R 5c , R 5d and R 5e are each independently selected from hydrogen, deuterium, halide, alkyl, alkenyl, alkoxy, alkylthio, amino, sulfonyl, aminosulfonyl, aminocarbonyl, acyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, hydroxyl or nitro; or any two adjacent groups selected together form an aryl, heteroaryl, cycloalkyl or heterocyclic ring; and R x is selected from O, NR x3 , sulfonyl or S; R x3 is selected from H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, or aryl; L x is selected from a bond, alkylene, alkenylene, alkynylene, cycloalkyl, cycloalkenyl, heterocyclic, aryl, heteroaryl or CR x4 R x5 ; R x4 and R x5 are each independently selected from H, D, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -C(O)OR x6 , or -C(O)NR x6 R x7 ; R x6 and R x7 are each independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl; R x2 is selected from -C(O)L x2 R x8 or a carboxyl bioisostere; L x2 is a bond or NR x3 ; R x8 is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, -OR x9 , N(R x9 ) 2 , - C(O)R x9 , -S(O) 2 R x9 , -C(O)OR x9 , -S(O) 2 N(R x9 ) 2 or -C(O)N(R x9 ) 2 ; and each R x9 is independently selected from H, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl. <EOS>