mhurhangee/patent-ind-claim-en huggingface dataset:
A method of controlling proliferation of an animal cell, the method comprising: a) genetically modifying one or more endogenous genes in the animal cell selected from the group consisting of Cdk1, Top2A, Cenpa, Birc5, and Eef2, the genetic modification comprising a DNA sequence encoding a negative selectable marker that is transcriptionally linked to a DNA sequence encoding each of the one or more genes, such that the negative selectable marker and the one or more genes are co-expressed; and b) controlling proliferation of the genetically modified animal cell with an inducer of the negative selectable marker. a) genetically modifying one or more endogenous genes in the animal cell selected from the group consisting of Cdk1, Top2A, Cenpa, Birc5, and Eef2, the genetic modification comprising a DNA sequence encoding a negative selectable marker that is transcriptionally linked to a DNA sequence encoding each of the one or more genes, such that the negative selectable marker and the one or more genes are co-expressed; and b) controlling proliferation of the genetically modified animal cell with an inducer of the negative selectable marker.
An article comprising: a substrate ; and a multi-layered ceramic barrier coating on the substrate , the multilayer ceramic barrier coating including, from the substrate outwards, a first layer of a first ceramic material and a second layer of a second ceramic material, the second ceramic material differing from the first ceramic material in composition, the first layer having a columnar microstructure and the second layer having a branched columnar microstructure ; characterised in that the first ceramic material is a low-dopant ceramic material and the second ceramic material is a high-dopant ceramic material, wherein the low-dopant ceramic material and the high-dopant ceramic material each include at least one of zirconium or hafnium and are independently doped with elements selected from the group consisting of rare earth elements; and in that the multi-layered ceramic barrier coating includes multiple first layers and multiple second layers . a substrate ; and a multi-layered ceramic barrier coating on the substrate , the multilayer ceramic barrier coating including, from the substrate outwards, a first layer of a first ceramic material and a second layer of a second ceramic material, the second ceramic material differing from the first ceramic material in composition, the first layer having a columnar microstructure and the second layer having a branched columnar microstructure ; characterised in that the first ceramic material is a low-dopant ceramic material and the second ceramic material is a high-dopant ceramic material, wherein the low-dopant ceramic material and the high-dopant ceramic material each include at least one of zirconium or hafnium and are independently doped with elements selected from the group consisting of rare earth elements; and in that the multi-layered ceramic barrier coating includes multiple first layers and multiple second layers .
An observation device comprising: an authorization controller to receive, via an out-of-band link, a pseudo random number associated with a particular time period; a partial tree generator coupled to the authorization controller, the partial tree generator to use the pseudo random number to generate a subset of a pseudo random number tree that corresponds to the particular time period; and a proximity verifier coupled to the partial tree generator, the proximity verifier to conduct a proximity determination of whether a detected beacon signal corresponds to one or more time-dependent branches of the subset of the pseudo random number tree; wherein either (i) the proximity verifier is to report that a mobile source of the beacon signal traveled within proximity of the observation device during the particular time period if the proximity determination indicates that the beacon signal corresponds to one or more time-dependent branches of the subset of the pseudo random number tree; or (ii) the observation device is a mobile observation device, and wherein the proximity verifier is to report that the mobile observation device traveled within proximity of a source of the beacon signal during the particular time period if the proximity determination indicates that the beacon signal corresponds to one or more time-dependent branches of the subset of the pseudo random number tree. an authorization controller to receive, via an out-of-band link, a pseudo random number associated with a particular time period; a partial tree generator coupled to the authorization controller, the partial tree generator to use the pseudo random number to generate a subset of a pseudo random number tree that corresponds to the particular time period; and a proximity verifier coupled to the partial tree generator, the proximity verifier to conduct a proximity determination of whether a detected beacon signal corresponds to one or more time-dependent branches of the subset of the pseudo random number tree;
A tire having a tread, the tread comprising: a center rib formed by two circumferential main grooves extending along the tire circumferential direction; a first shoulder rib disposed axially outward from the center rib and one of the circumferential main grooves ; and a second shoulder rib disposed axially outward from the center rib and the other of the two circumferential main grooves ; the center rib having a repeated first group of three sipes that is repeated along the circumferential direction of the tire, each first group of three sipes having a first sipe being inclined radially inward under a first angle relative to the tire radial direction, a second sipe being inclined radially inward under a second angle relative to the tire radial direction, and a third sipe being inclined radially inward under third angle relative to the tire radial direction; wherein the second angle is in a range of from -1 degrees to +1 degrees; wherein the first sipe is inwardly angled circumferentially away from the second sipe; wherein the third sipe is inwardly angled circumferentially away from the second sipe; and wherein the first and third angles are oppositely radially inclined to each other and the radial direction; characterized in that the first angle is in a range of from +17 to +23 degrees and in that the third angle is in a range of from -17 to -23 degrees. a center rib formed by two circumferential main grooves extending along the tire circumferential direction; a first shoulder rib disposed axially outward from the center rib and one of the circumferential main grooves ; and a second shoulder rib disposed axially outward from the center rib and the other of the two circumferential main grooves ; the center rib having a repeated first group of three sipes that is repeated along the circumferential direction of the tire, each first group of three sipes having a first sipe being inclined radially inward under a first angle relative to the tire radial direction, a second sipe being inclined radially inward under a second angle relative to the tire radial direction, and a third sipe being inclined radially inward under third angle relative to the tire radial direction; wherein the second angle is in a range of from -1 degrees to +1 degrees; wherein the first sipe is inwardly angled circumferentially away from the second sipe; wherein the third sipe is inwardly angled circumferentially away from the second sipe; and wherein the first and third angles are oppositely radially inclined to each other and the radial direction; characterized in that the first angle is in a range of from +17 to +23 degrees and in that the third angle is in a range of from -17 to -23 degrees.
A binding protein comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first polypeptide chain of the binding protein comprises a structure represented by the formula: V L2 -L 1 -V L1 -L 2 -C L [I] and a second polypeptide chain of the binding protein comprises a structure represented by the formula: V H1 -L 3 -V H2 -L 4 -C H1 -hinge-C H2 -C H3 [II] and a third polypeptide chain of the binding protein comprises a structure represented by the formula: V H3 -C H1 -hinge-C H2 -C H3 [III] and a fourth polypeptide chain of the binding protein comprises a structure represented by the formula: V L3 -C L [IV] wherein: V L1 is a first immunoglobulin light chain variable domain; V L2 is a second immunoglobulin light chain variable domain; V L3 is a third immunoglobulin light chain variable domain; V H1 is a first immunoglobulin heavy chain variable domain; V H2 is a second immunoglobulin heavy chain variable domain; V H3 is a third immunoglobulin heavy chain variable domain; C L is an immunoglobulin light chain constant domain; C H1 is an immunoglobulin C H1 heavy chain constant domain; C H2 is an immunoglobulin C H2 heavy chain constant domain; C H3 is an immunoglobulin C H3 heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1 and C H2 domains; and L 1 , L 2 , L 3 and L 4 are amino acid linkers; and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair. V L1 is a first immunoglobulin light chain variable domain; V L2 is a second immunoglobulin light chain variable domain; V L3 is a third immunoglobulin light chain variable domain; V H1 is a first immunoglobulin heavy chain variable domain; V H2 is a second immunoglobulin heavy chain variable domain; V H3 is a third immunoglobulin heavy chain variable domain; C L is an immunoglobulin light chain constant domain; C H1 is an immunoglobulin C H1 heavy chain constant domain; C H2 is an immunoglobulin C H2 heavy chain constant domain; C H3 is an immunoglobulin C H3 heavy chain constant domain; hinge is an immunoglobulin hinge region connecting the C H1 and C H2 domains; and L 1 , L 2 , L 3 and L 4 are amino acid linkers; and wherein the polypeptide of formula I and the polypeptide of formula II form a cross-over light chain-heavy chain pair.
A bung plug closure for bung containers having a bung plug for being arranged in a bung neck of the bung container and having a seal cap for sealing a plug depression formed in the bung plug , said plug depression comprising a receiving area for receiving a resilient engagement body formed on the seal cap , and said bung plug comprising tool engagements , which are arranged at an inner wall of the plug depression and which are distanced to each other via gaps and which delimit the receiving area using inner surfaces which at least in sections form guide surfaces for axially guiding an annular locking protrusion of the engagement body when inserting the engagement body into the plug depression , counter-locking elements for locking the annular locking protrusion of the engagement body to the bung plug being provided in the plug depression , said counter-locking elements radially inward protruding over the annular locking protrusion of the engagement body after locking, characterized in that the counter-locking elements are arranged in the area of the gaps above an annular frame , which is formed outside of the gaps via lower sections of the inner surfaces , in such a manner that the locking protrusion is received by the annular frame . characterized in that the counter-locking elements are arranged in the area of the gaps above an annular frame , which is formed outside of the gaps via lower sections of the inner surfaces , in such a manner that the locking protrusion is received by the annular frame .
A liquid photo initiating compound, which is represented by the following Formula I: wherein, in Formula I, R 1 and R 2 are independently H or C 1 -C 3 alkyl, and R 3 is H or methyl.
Energy chain with a plurality of chain links articulatedly connected to one another and consecutive in the chain longitudinal direction , wherein each chain link has two side links arranged at a distance to one another which are detachably connected to one another by means of at least one frame web , wherein the frame webs connecting each two side links detachably to one another are connected to each side link by means of a fastening element which engages through an opening extending in a chain transverse direction from the outside of the side link in question to its inside and is detachably connected with an end arranged in a recess opening to an underside of the side link in question and is preferably locked in place, characterised in that at least one part of the fastening elements in each case has a fastening part protruding through the respective opening and connecting to the respective frame web , a connection part protruding to the outside of the respective side link from the opening , extending to the underside of the side link and connecting to the fastening part and a damping part connecting to the connection part and engaging under the side link on its underside .
Method of layer-by-layer production of objects by laser transfer printing in a 3D print apparatus comprising at least one plate , at least one laser source , and at least one carrier cylinder ; wherein the material of the carrier cylinder is transparent to the laser beams from the laser source and the laser source is disposed above the carrier cylinder , wherein the method comprises the following steps: (a) coating at least part of the outer surface of the carrier cylinder with at least one print material ; (b) irradiating the carrier cylinder with laser beams from the laser source , such that at least a portion of the applied print material is detached from the carrier cylinder and is transferred to the plate , to an extrinsic component positioned thereon or to a previously applied print material layer; wherein the irradiation is effected in such a way that the laser beams hit the print material applied to the lower side of the carrier cylinder directly through both walls of the carrier cylinder from outside the carrier cylinder , (c) forming a print material layer by curing the print material transferred in step (b), (d) repeating steps (a) to (c) until the object has been fully constructed. (a) coating at least part of the outer surface of the carrier cylinder with at least one print material ; (b) irradiating the carrier cylinder with laser beams from the laser source , such that at least a portion of the applied print material is detached from the carrier cylinder and is transferred to the plate , to an extrinsic component positioned thereon or to a previously applied print material layer; wherein the irradiation is effected in such a way that the laser beams hit the print material applied to the lower side of the carrier cylinder directly through both walls of the carrier cylinder from outside the carrier cylinder , (c) forming a print material layer by curing the print material transferred in step (b), (d) repeating steps (a) to (c) until the object has been fully constructed.
A method for wireless communications at an access point , comprising: identifying an operating condition of a station that comprises a primary radio and a wakeup radio ; adapting a transmission timing of a synchronization beacon associated with the wakeup radio of the station based at least in part on the identified operating condition; and transmitting the synchronization beacon according to the adapted transmission timing, wherein identifying the operating condition of the station comprises: determining that the wakeup radio of the station is in an active status; and refraining from transmitting one or more instances (325-c) of the synchronization beacon based at least in part on determining that the wakeup radio of the station is in the active status. identifying an operating condition of a station that comprises a primary radio and a wakeup radio ; adapting a transmission timing of a synchronization beacon associated with the wakeup radio of the station based at least in part on the identified operating condition; and transmitting the synchronization beacon according to the adapted transmission timing, wherein identifying the operating condition of the station comprises: determining that the wakeup radio of the station is in an active status; and refraining from transmitting one or more instances (325-c) of the synchronization beacon based at least in part on determining that the wakeup radio of the station is in the active status. determining that the wakeup radio of the station is in an active status; and refraining from transmitting one or more instances (325-c) of the synchronization beacon based at least in part on determining that the wakeup radio of the station is in the active status.
A solar ray concentration system comprising a vertically projecting mast structure (1.1) which comprises a plurality of systems which are mounted one on top of the other down said mast structure (1.1) from top to bottom, and in which each of said systems comprises a flat collection mirror (1.4), a Plano concave mirror (1.7), a Plano convex mirror (1.6), an inner 45 degree inclined flat mirror (1.5), and an outer 45 degree inclined flat mirror (1.10), wherein said flat collection mirror (1.4) of each system is sustained by two parallel horizontally projecting members (1.3) which sustain the Plano concave mirror (1.7) of the system positioned on top of the system concerned, wherein the Plano concave mirror (1.7) faces towards the mast structure (1.1) and is positioned below said flat collection mirror (1.4), and concentrates the solar rays (1.8) deflected by the flat collection mirror (1.4) towards the Plano convex mirror (1.6) which faces opposite to said mast structure (1.1), and which hence faces towards said Plano concave mirror (1.7), the Piano convex mirror (1.6) being positioned in front of and slightly above of said Plano concave mirror (1.7), and nearer to said vertical mast structure (1.1) than said Plano concave mirror (1.7), the inner 45 degree inclined flat mirror (1.5) is positioned below the upper system's Piano convex mirror (1.6) and partly faces upwards towards said Plano convex mirror (1.6) and partly horizontally away from said mast structure (1.1) and so towards the outer 45 degree inclined flat mirror (1.10), which is positioned horizontally in front of said inner 45 degree inclined flat mirror (1.5) and partly faces towards the mast structure (1.1) and so towards the inner 45 degree inclined mirror (1.5), and partly faces downwards towards the Plano concave mirror (1.7) of the lower system, which is positioned below said outer 45 degree inclined flat mirror (1.10), as well as below the whole surface of said lower system's flat collection mirror (1.4).
A refrigerator including a cabinet in which a storage space is formed, a door opening and closing the storage space, and a transparent panel assembly mounted on the door to see through a space behind the door , wherein the transparent panel assembly comprises: a front panel defining at least a part of a front appearance of the door and made of a glass material and accommodating a see-through region and a screening region , the screening region being formed at peripheries of the front panel ; a rear panel defining at least a part of a rear appearance of the door and made of a transparent material and accommodating a see-through region and a screening region , the screening region being formed at peripheries of the rear panel ; and an intermediate member connected between the front panel and the rear panel and made of a transparent plastic member, and the intermediate member comprises: an edge portion having both ends connected to the screening region of the front panel and the screening region of the rear panel ; and a partition portion formed to cross an inner volume of the edge portion to partition a gap between the front panel and the rear panel to thereby form a sealed insulation layer , characterized in that the intermediate member being injection-molded such that the entire structure of the intermediate member is integrally molded. a front panel defining at least a part of a front appearance of the door and made of a glass material and accommodating a see-through region and a screening region , the screening region being formed at peripheries of the front panel ; a rear panel defining at least a part of a rear appearance of the door and made of a transparent material and accommodating a see-through region and a screening region , the screening region being formed at peripheries of the rear panel ; and an intermediate member connected between the front panel and the rear panel and made of a transparent plastic member, and the intermediate member comprises: an edge portion having both ends connected to the screening region of the front panel and the screening region of the rear panel ; and a partition portion formed to cross an inner volume of the edge portion to partition a gap between the front panel and the rear panel to thereby form a sealed insulation layer , characterized in that the intermediate member being injection-molded such that the entire structure of the intermediate member is integrally molded. an edge portion having both ends connected to the screening region of the front panel and the screening region of the rear panel ; and a partition portion formed to cross an inner volume of the edge portion to partition a gap between the front panel and the rear panel to thereby form a sealed insulation layer , characterized in that the intermediate member being injection-molded such that the entire structure of the intermediate member is integrally molded.
Tensioning device for a traction drive, comprising: a base member ; at least one tensioning arm which is pivotably supported relative to the base member about a pivot axis (A4, A6) and comprises a tensioning roller which is rotatably supported on a bearing carrier of the tensioning arm ; spring means for resiliently loading the tensioning arm , wherein the spring means extend between a first spring support of the tensioning arm and a second spring support of the tensioning device about the pivot axis (A4, A6), characterised by an adjusting mechanism for adjusting the first spring support relative to the bearing carrier of the tensioning roller in circumferential direction about the pivot axis (A4, A6), so that in the mounted state of the tensioning device the angle between the first spring support and the second spring support with respect to the pivot axis (A4, A6) and thus the spring pre-tensioning force of the spring means is adjustable. a base member ; at least one tensioning arm which is pivotably supported relative to the base member about a pivot axis (A4, A6) and comprises a tensioning roller which is rotatably supported on a bearing carrier of the tensioning arm ; spring means for resiliently loading the tensioning arm , wherein the spring means extend between a first spring support of the tensioning arm and a second spring support of the tensioning device about the pivot axis (A4, A6), characterised by an adjusting mechanism for adjusting the first spring support relative to the bearing carrier of the tensioning roller in circumferential direction about the pivot axis (A4, A6), so that in the mounted state of the tensioning device the angle between the first spring support and the second spring support with respect to the pivot axis (A4, A6) and thus the spring pre-tensioning force of the spring means is adjustable.