mhurhangee/patent-ind-claim-en huggingface dataset:
A humanized RS7 anti-Trop-2 antibody or antigen-binding fragment thereof conjugated to a cytotoxic agent, for use in a method of treating pancreatic cancer comprising: a) administering to a subject with pancreatic cancer the anti-Trop-2 antibody or antigen-binding fragment thereof conjugated to a cytotoxic agent, wherein the anti-Trop-2 antibody or fragment thereof comprises the light chain CDR sequences CDR1 (KASQDVSIAVA, SEQ ID NO: 7); CDR2 (SASYRYT, SEQ ID NO: 8); and CDR3 (QQHYITPLT, SEQ ID NO: 9) and the heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO: 10); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO. 11) and CDR3 (GGFGSSYWYFDV, SEQ ID NO: 12), wherein the cytotoxic agent is SN-38 conjugated to the antibody or antigen-binding fragment by linker CL2A, wherein the structure of the immunoconjugate is MAb-CL2A-SN-38 and b) administering to said subject a PAM4 anti-pancreatic cancer mucin antibody or antigen- binding fragment thereof conjugated to a radionuclide, wherein the anti-pancreatic cancer mucin antibody or fragment thereof comprises the light complementarity determining region (CDR) sequences CDR1 (SASSSVSSSYLY, SEQ ID NO: 1); CDR2 (STSNLAS, SEQ ID NO: 2); and CDR3 (HQWNRYPYT, SEQ ID NO: 3); and the heavy chain CDR sequences CDR1 (SYVLH, SEQ ID NO: 4); CDR2 (YINPYNDGTQYNEKFKG, SEQ ID NO: 5) and CDR3 (GFGGSYGFAY, SEQ ID NO: 6), and wherein the radionuclide is 90 Y. a) administering to a subject with pancreatic cancer the anti-Trop-2 antibody or antigen-binding fragment thereof conjugated to a cytotoxic agent, wherein the anti-Trop-2 antibody or fragment thereof comprises the light chain CDR sequences CDR1 (KASQDVSIAVA, SEQ ID NO: 7); CDR2 (SASYRYT, SEQ ID NO: 8); and CDR3 (QQHYITPLT, SEQ ID NO: 9) and the heavy chain CDR sequences CDR1 (NYGMN, SEQ ID NO: 10); CDR2 (WINTYTGEPTYTDDFKG, SEQ ID NO. 11) and CDR3 (GGFGSSYWYFDV, SEQ ID NO: 12), wherein the cytotoxic agent is SN-38 conjugated to the antibody or antigen-binding fragment by linker CL2A, wherein the structure of the immunoconjugate is MAb-CL2A-SN-38 and b) administering to said subject a PAM4 anti-pancreatic cancer mucin antibody or antigen- binding fragment thereof conjugated to a radionuclide, wherein the anti-pancreatic cancer mucin antibody or fragment thereof comprises the light complementarity determining region (CDR) sequences CDR1 (SASSSVSSSYLY, SEQ ID NO: 1); CDR2 (STSNLAS, SEQ ID NO: 2); and CDR3 (HQWNRYPYT, SEQ ID NO: 3); and the heavy chain CDR sequences CDR1 (SYVLH, SEQ ID NO: 4); CDR2 (YINPYNDGTQYNEKFKG, SEQ ID NO: 5) and CDR3 (GFGGSYGFAY, SEQ ID NO: 6), and wherein the radionuclide is 90 Y.
High temperature thermal insulation material, in particular for gas turbine components, comprising a porous ceramic matrix of yttria-stabilized zirconia (YSZ) having a porous microstructure; and hafnia (HfO 2 ) particles incorporated within the porous ceramic matrix in form of aggregated clusters; wherein hafnia clusters are made of aggregated hafnia particles and are randomly distributed in the ceramic matrix and have a diameter of about 1 to 30 μm.
A stack module box having a fuel cell stack which is accommodated therein and has at least one fuel cell , in conjunction with a plurality of media guides which are guided to the stack module box and from which media can be delivered to the stack module box or can be received from the stack module box , wherein at least two of the media guides have electrically conductive regions for conducting current away from the fuel cell stack and wherein connecting lines are led from the fuel cell stack to the electrically conductive regions and away from these.
A fuel nozzle comprising: a proximal member having: a first mating portion defined around an assembly axis ; a first fluid conduit internal to the proximal member and spaced apart from the assembly axis ; and a first stop facing a first circumferential direction; a distal member having: a second mating portion configured for axial engagement with the first mating portion along the assembly axis ; a second stop facing a second circumferential direction, the second circumferential direction opposite the first circumferential direction and configured to abut against the first stop when the distal member and proximal member are axially engaged to one another in a predetermined relative circumferential alignment; and a second fluid conduit internal to the distal member and spaced apart from the assembly axis , the second fluid conduit being in fluid flow communication with the first fluid conduit internally to the fuel nozzle when the second stop abuts the first stop . a proximal member having: a first mating portion defined around an assembly axis ; a first fluid conduit internal to the proximal member and spaced apart from the assembly axis ; and a first stop facing a first circumferential direction; a first mating portion defined around an assembly axis ; a first fluid conduit internal to the proximal member and spaced apart from the assembly axis ; and a first stop facing a first circumferential direction; a distal member having: a second mating portion configured for axial engagement with the first mating portion along the assembly axis ; a second stop facing a second circumferential direction, the second circumferential direction opposite the first circumferential direction and configured to abut against the first stop when the distal member and proximal member are axially engaged to one another in a predetermined relative circumferential alignment; and a second fluid conduit internal to the distal member and spaced apart from the assembly axis , the second fluid conduit being in fluid flow communication with the first fluid conduit internally to the fuel nozzle when the second stop abuts the first stop . a second mating portion configured for axial engagement with the first mating portion along the assembly axis ; a second stop facing a second circumferential direction, the second circumferential direction opposite the first circumferential direction and configured to abut against the first stop when the distal member and proximal member are axially engaged to one another in a predetermined relative circumferential alignment; and a second fluid conduit internal to the distal member and spaced apart from the assembly axis , the second fluid conduit being in fluid flow communication with the first fluid conduit internally to the fuel nozzle when the second stop abuts the first stop .
A method, performed by a user equipment, UE, for wireless communication, comprising: identifying (1405; 1505) a default monitoring periodicity for monitoring a control channel for a slot format indicator, SFI; identifying (1410; 1515) a dynamic monitoring periodicity for monitoring the control channel for the SFI based at least in part on a received SFI; monitoring (1415; 1530) the control channel for the SFI based at least in part on the dynamic monitoring periodicity; and wherein the dynamic monitoring periodicity is greater than the default monitoring periodicity. identifying (1405; 1505) a default monitoring periodicity for monitoring a control channel for a slot format indicator, SFI; identifying (1410; 1515) a dynamic monitoring periodicity for monitoring the control channel for the SFI based at least in part on a received SFI; monitoring (1415; 1530) the control channel for the SFI based at least in part on the dynamic monitoring periodicity; and wherein the dynamic monitoring periodicity is greater than the default monitoring periodicity.
A straddled vehicle comprising: an air cleaner including an air cleaner case , an element for cleaning the air arranged inside the air cleaner case , and a duct that is attached to the element and at least a portion of which is arranged inside the air cleaner case , wherein the duct guides the air toward the element ; and a resonator having an outer wall arranged around the duct , wherein the duct and the outer wall together define at least a portion of a resonance chamber of the resonator , the element is attached to the air cleaner case ; characterized in that , the outer wall is attached to the element and not attached directly to the air cleaner case . an air cleaner including an air cleaner case , an element for cleaning the air arranged inside the air cleaner case , and a duct that is attached to the element and at least a portion of which is arranged inside the air cleaner case , wherein the duct guides the air toward the element ; and a resonator having an outer wall arranged around the duct , wherein the duct and the outer wall together define at least a portion of a resonance chamber of the resonator , the element is attached to the air cleaner case ; characterized in that , the outer wall is attached to the element and not attached directly to the air cleaner case .
An apparatus comprising: a plurality of stretchable leads, each of the plurality of stretchable leads including a stretchable polymer and an associated electrode which is to receive electrical signals generated in response to a subject's heart and to pass the received electrical signals along a respective one of plurality of stretchable leads; and a patch including a stretchable substrate integrated with the plurality of stretchable leads and including a circuitry area for circuitry to reside for collecting the electrical signals passed along each of the plurality of stretchable leads, wherein each of the plurality of stretchable leads is to be on a subject side of the patch. a plurality of stretchable leads, each of the plurality of stretchable leads including a stretchable polymer and an associated electrode which is to receive electrical signals generated in response to a subject's heart and to pass the received electrical signals along a respective one of plurality of stretchable leads; and a patch including a stretchable substrate integrated with the plurality of stretchable leads and including a circuitry area for circuitry to reside for collecting the electrical signals passed along each of the plurality of stretchable leads, wherein each of the plurality of stretchable leads is to be on a subject side of the patch.
A stylet for placing a catheter in a vasculature of a patient, comprising: an ECG sensor assembly including an electrode extending from a proximal end to a distal end of the stylet , the proximal end configured to couple with an ECG sensor ; a magnetic assembly disposed along a distal tip portion of the stylet , the magnetic assembly producing a magnetic field; a core wire extending proximally away from the magnetic assembly ; and a coil defining a lumen , the coil extending along a distal portion of the stylet , wherein a distal portion of the core wire is disposed within the lumen , wherein the magnetic assembly comprises a plurality of magnet elements disposed within the lumen , wherein one or more magnet elements are attached to the coil . an ECG sensor assembly including an electrode extending from a proximal end to a distal end of the stylet , the proximal end configured to couple with an ECG sensor ; a magnetic assembly disposed along a distal tip portion of the stylet , the magnetic assembly producing a magnetic field; a core wire extending proximally away from the magnetic assembly ; and a coil defining a lumen , the coil extending along a distal portion of the stylet , wherein a distal portion of the core wire is disposed within the lumen , wherein the magnetic assembly comprises a plurality of magnet elements disposed within the lumen , wherein one or more magnet elements are attached to the coil .
A surgical system comprising: an implant comprising: a first endplate ; a second endplate ; a first ramped body extending between the first endplate and the second endplate ; and an actuator in engagement with the first ramped body , wherein rotation of the actuator causes translation of the first ramped body , thereby causing expansion of the implant ; and an inserter configured to engage the implant , wherein the inserter comprises an outer shaft and a distal engagement portion at an angle relative to the outer shaft , wherein the distal engagement portion comprises a first engagement tip receivable in an opening in the implant and a second engagement tip configured to engage the actuator . an implant comprising: a first endplate ; a second endplate ; a first ramped body extending between the first endplate and the second endplate ; and an actuator in engagement with the first ramped body , wherein rotation of the actuator causes translation of the first ramped body , thereby causing expansion of the implant ; and a first endplate ; a second endplate ; a first ramped body extending between the first endplate and the second endplate ; and an actuator in engagement with the first ramped body , wherein rotation of the actuator causes translation of the first ramped body , thereby causing expansion of the implant ; and an inserter configured to engage the implant , wherein the inserter comprises an outer shaft and a distal engagement portion at an angle relative to the outer shaft , wherein the distal engagement portion comprises a first engagement tip receivable in an opening in the implant and a second engagement tip configured to engage the actuator .
A poultry watering system mounted within a poultry house having a floor comprising: a water supply reservoir containing an amount of potable water therein, the potable water within the reservoir defining a water level associated with the reservoir; one or more water distribution points for providing the potable water to a flock of poultry at a desired pressure level; each of the one or more water distribution points comprises a drinker line and a water column having a water level , the drinker line having a plurality of drinker nipples for providing the potable water to the flock of poultry at the desired pressure level, wherein the water level within the water column established the desired pressure level of the potable water at the drinker nipples; the water supply reservoir and the water distribution points are positioned at relatively similar heights above the floor such that the water level within the water column is the same height above the floor as the water level associated with the reservoir; and water conduit connecting the water supply reservoir to the one or more water distribution points, the water conduit configured to be substantially filled with pressurized potable water maintained at a negative pressure; wherein the desired pressure level of the potable water provided to the flock is directly responsive to the water level associated with the reservoir. a water supply reservoir containing an amount of potable water therein, the potable water within the reservoir defining a water level associated with the reservoir; one or more water distribution points for providing the potable water to a flock of poultry at a desired pressure level; each of the one or more water distribution points comprises a drinker line and a water column having a water level , the drinker line having a plurality of drinker nipples for providing the potable water to the flock of poultry at the desired pressure level, wherein the water level within the water column established the desired pressure level of the potable water at the drinker nipples; the water supply reservoir and the water distribution points are positioned at relatively similar heights above the floor such that the water level within the water column is the same height above the floor as the water level associated with the reservoir; and water conduit connecting the water supply reservoir to the one or more water distribution points, the water conduit configured to be substantially filled with pressurized potable water maintained at a negative pressure;
A wire electric discharge machine having a core fixing function of fixing a core produced by electric discharge machining and a workpiece , by relatively moving a wire electrode and a workpiece in accordance with a machining program, by performing electrode discharge machining of the workpiece by electric discharge generated between the wire electrode and the workpiece, and by attaching and depositing machining debris produced by the electric discharge machining to a machining groove , the wire electric discharge machine characterized by comprising: a core image acquiring unit for acquiring an image of the core ; a control device having a processor and being connected to the core image acquiring unit , the control device being configured for determining whether the core is fixed from the image acquired by the core image acquiring unit ; and stopping the electric discharge machining, when the control device determines that the core is not fixed. a core image acquiring unit for acquiring an image of the core ; a control device having a processor and being connected to the core image acquiring unit , the control device being configured for determining whether the core is fixed from the image acquired by the core image acquiring unit ; and stopping the electric discharge machining, when the control device determines that the core is not fixed. determining whether the core is fixed from the image acquired by the core image acquiring unit ; and stopping the electric discharge machining, when the control device determines that the core is not fixed.
A resin composition (A) comprising the following components and : a composition (a1) including at least two kinds of ethylene-vinyl acetate copolymers having different vinyl acetate contents; and a copolymer (a2) that is at least one copolymer selected from an ethylene-acrylic acid copolymer and an ethylene-methacrylic acid copolymer, wherein an absolute value of a difference between a solubility parameter of one of the ethylene-vinyl acetate copolymers in the composition (a1) and a solubility parameter of the ethylene-acrylic acid copolymer or the ethylene-methacrylic acid copolymer in the copolymer (a2) is not more than 0.3 MPa, the solubility parameters being calculated according to Fedors method. a composition (a1) including at least two kinds of ethylene-vinyl acetate copolymers having different vinyl acetate contents; and a copolymer (a2) that is at least one copolymer selected from an ethylene-acrylic acid copolymer and an ethylene-methacrylic acid copolymer,
A method of facilitating a transaction during a voice call between a caller and an agent via a call processor , the method comprising: activating (S1) a secure mode of the call processor adapted to prevent sensitive information relating to the transaction provided by the caller from being accessible by the agent ; transmitting (S2) a notification that the secure mode has been activated via a voice channel used for the voice call to an electronic wallet accessible by the caller in which the sensitive information is stored, the electronic wallet being adapted not to transmit sensitive information unless the secure mode is determined to be active; receiving (S9) from the electronic wallet an acknowledgement of receipt of the notification and subsequently sensitive information; and processing the transaction in dependence on the sensitive information received from the electronic wallet . activating (S1) a secure mode of the call processor adapted to prevent sensitive information relating to the transaction provided by the caller from being accessible by the agent ; transmitting (S2) a notification that the secure mode has been activated via a voice channel used for the voice call to an electronic wallet accessible by the caller in which the sensitive information is stored, the electronic wallet being adapted not to transmit sensitive information unless the secure mode is determined to be active; receiving (S9) from the electronic wallet an acknowledgement of receipt of the notification and subsequently sensitive information; and processing the transaction in dependence on the sensitive information received from the electronic wallet . receiving (S9) from the electronic wallet an acknowledgement of receipt of the notification and subsequently sensitive information; and processing the transaction in dependence on the sensitive information received from the electronic wallet .
A method for resuming an Adaptive Bitrate Streaming, ABR, session that has been interrupted between a system having a plurality of nodes and a client device ; subsequent to interruption of service in the ABR session between a first node and the client device in which the first node delivers a service to the client device, receiving a session resume request from the client device at a second node in the system, the session resume request including information allowing the second node to obtain a session identifier specifying the ABR session; hashing the session identifier; searching a currently valid hash map that maps a hash of the session identifier to the nodes in the system for a current system configuration, the search being performed to identify a system node on which the session state data for the ABR session is stored; if the session state data is not located using the currently valid hash map, searching at least one earlier generation hash map that is valid for a previous configuration of the system; upon identifying the system node on which the session state data is stored, retrieving the session state data from the system node; and using the session state data so that the second node is able to resume delivery of the service to the client device. subsequent to interruption of service in the ABR session between a first node and the client device in which the first node delivers a service to the client device, receiving a session resume request from the client device at a second node in the system, the session resume request including information allowing the second node to obtain a session identifier specifying the ABR session; hashing the session identifier; searching a currently valid hash map that maps a hash of the session identifier to the nodes in the system for a current system configuration, the search being performed to identify a system node on which the session state data for the ABR session is stored; if the session state data is not located using the currently valid hash map, searching at least one earlier generation hash map that is valid for a previous configuration of the system; upon identifying the system node on which the session state data is stored, retrieving the session state data from the system node; and using the session state data so that the second node is able to resume delivery of the service to the client device.
Cutting tool (1, 1', 1'', 1′′′, 1ʺʺ, 1′′′ʺ) for severing a non-metallic material, comprising a holding element (6, 6", 6′′′, 6ʺʺ) , a cutting element (3, 3', 3'', 3′′′ʺ), which is held on the holding element (6, 6'', 6′′′ , 6ʺʺ) for the purpose of making cutting contact with the non-metallic material, and a boundary region , which adjoins a holding material region of the holding element (6, 6'', 6′′′ , 6ʺʺ) and a cutting material region of the cutting element (3, 3', 3'', 3′′′ʺ), wherein a deformation resistance to elastic deformation of the holding material region is greater than a deformation resistance to elastic deformation of the cutting material region , wherein the holding element (6, 6", 6′′′, 6ʺʺ) and the cutting element (3, 3', 3" , 3′′′ʺ) are connected to one another in a materially bonded manner, wherein the cutting element (3, 3', 3'', 3′′′ʺ) has cutting teeth , characterized in that the holding material region consists of a holding material and the cutting material region consists of a cutting material, which is different from the holding material, wherein a modulus of elasticity of the holding material is greater than a modulus of elasticity of the cutting material.