mhurhangee/patent-ind-claim-en huggingface dataset:
A method of fabricating a three-dimensional, engineered, biological tumor model, characterized in that the method comprises: a. providing an adipocyte differentiation signal to human preadipocytes; b. preparing a solid or semi-solid stromal bio-ink, the stromal bio-ink comprising a plurality of stromal cell types, the stromal cell types comprising the human preadipocytes of a.; c. preparing a solid or semi-solid tumor bio-ink, the tumor bio-ink comprising a cancer cell type; d. bioprinting the stromal bio-ink and the tumor bio-ink from a bioprinter, such that the tumor bio-ink is in contact with the stromal bio-ink; and e. maturing the bioprinted stromal and tumor bio-inks in a cell culture media to allow the cells to cohere to form a three-dimensional, engineered, biological tumor model; wherein the bio-inks comprise cells, cells combined with an excipient or extrusion compound, or aggregates of cells, wherein the stromal bio-ink comprises differentiating human preadipocytes at the time of bioprinting that differentiate into human adipocytes post-bioprinting, and wherein the tumor tissue is surrounded on all sides by the stromal tissue. a. providing an adipocyte differentiation signal to human preadipocytes; b. preparing a solid or semi-solid stromal bio-ink, the stromal bio-ink comprising a plurality of stromal cell types, the stromal cell types comprising the human preadipocytes of a.; c. preparing a solid or semi-solid tumor bio-ink, the tumor bio-ink comprising a cancer cell type; d. bioprinting the stromal bio-ink and the tumor bio-ink from a bioprinter, such that the tumor bio-ink is in contact with the stromal bio-ink; and e. maturing the bioprinted stromal and tumor bio-inks in a cell culture media to allow the cells to cohere to form a three-dimensional, engineered, biological tumor model; wherein the bio-inks comprise cells, cells combined with an excipient or extrusion compound, or aggregates of cells, wherein the stromal bio-ink comprises differentiating human preadipocytes at the time of bioprinting that differentiate into human adipocytes post-bioprinting, and wherein the tumor tissue is surrounded on all sides by the stromal tissue.
A device for coupling optical signals into at least one waveguide , the device comprising at least one send-site circuit , which based on incoming signals from send-site terminal contacts actuates at least one electro-optical converter , which sends out the optical signals in the direction of the axis of the waveguide , - wherein the electro-optical converter is incorporated, in particular embedded, in at least one send-site reception/alignment module , - wherein the send-site reception/alignment module comprises at least one groove- or trough-shaped depression for aligning the waveguide in relation to the electro-optical converter , and - wherein the send-site reception/alignment module is, in a force-fit manner, incorporated, in particular fitted, in a recess provided in a send-site substrate , characterized in that the depression is laterally arranged at an alignment part of the reception/alignment module , said alignment part extending in an axial direction of the waveguide , the depression thereby providing an alignment aid, wherein, on the other side of the waveguide , the counterpart is formed by an inner wall of the recess . - wherein the electro-optical converter is incorporated, in particular embedded, in at least one send-site reception/alignment module , - wherein the send-site reception/alignment module comprises at least one groove- or trough-shaped depression for aligning the waveguide in relation to the electro-optical converter , and - wherein the send-site reception/alignment module is, in a force-fit manner, incorporated, in particular fitted, in a recess provided in a send-site substrate ,
A compound of formula (I), or a pharmaceutically acceptable salt thereof wherein A is selected from the group consisting of wherein the nitrogen atom designated with the asterisk * is bound to the 4-cyanophenyl group and the carbon atom designated with # is bound to the carbon atom of the 2-oxo-2,3-dihydroimidazole ring; X is selected from the group consisting of or is selected from the group consisting of R 1 is selected from the group consisting of n is an integer from 1 to 4; m is 0 or an integer from 1 to 4; t is 0 or an integer from 1 to 4; y is an integer from 1 to 4; w is an integer from 1 to 4; z is 0 or 1; l is 0 or 1; R 2 is -H or linear or branched -(C 1 -C 4 )alkyl; R 3 is linear or branched -(C 1 -C 4 )alkyl or R 2 and R 3 may form together a cycloalkyl; R 4 is selected from the group consisting of -arylene-(C 1 -C 4 )alkylene-NR d R e , -arylene-(C 1 -C 4 )alkylene-N + R a R b R c , -heteroarylene-(C 1 -C 4 )alkylene-NR d R e , -heteroarylene-(C 1 -C 4 )alkylene-N + R a R b R c and heteroaryl, wherein any of such arylene-(C 1 -C 4 )alkylene-NR d R e , -arylene-(C 1 -C 4 )alkylene-N + R a R b R c , -heteroarylene-(C 1 -C 4 )alkylene-NR d R e , -heteroarylene-(C 1 -C 4 )alkylene-N + R a R b R c and heteroaryl may be optionally substituted by one or more -(C 1 -C 4 )alkyl or R 4 is selected from the group consisting of R 5 is selected from the group consisting of aryl-(C 1 -C 4 )alkylenoxy-, linear or branched (C 1 -C 4 )alkyl-OC(O)-NH-, -(CH 2 ) t -N + R a R b R c , -C(O)-N(R 10 )(C 1 -C 4 )alkylene-NR d R e , -C(O)N(R 10 )(C 1 -C 4 )alkylene-N + R a R b R c , -C(O)O(C 1 -C 4 )alkylene-NR d R e , -C(O)O(C 1 -C 4 )alkylene-N + R a R b R c , -(CH 2 ) t NHC(O)-(C 1 -C 4 )alkylene-NR d R e , -(CH 2 ) t C(O)-(C 1 -C 4 )alkylene-N + R a R b R c , or is selected from a group consisting of R 6 is selected from the group consisting of aryl-(C 1 -C 4 )alkylene-OCO-, CF 3 C(O)-, aryl-(C 1 -C 4 )alkylene, linear or branched (C 1 -C 4 )alkyl-OC(O)-, -C(O)-(C 1 -C 4 )alkylene-NR d R e , -C(O)-(C 1 -C 4 )alkylene-N + R a R b R c , -C(O)O-(C 1 -C 4 )alkylene-NR d R e , -C(O)O-(C 1 -C 4 )alkylene-N + R a R b R c -C(O)-N(R 10 )(C 1 -C 4 )alkylene-NR d R e , -C(O)N(R 10 )(C 1 -C 4 )alkylene-N + R a R b R c ; R a is -(C 1 -C 4 )alkyl; R b is -(C 1 -C 4 )alkyl; R c is selected from -(C 1 -C 4 )alkyl, aryl-(C 1 -C 4 )alkylene and heteroaryl-(C 1 -C 4 )alkylene, wherein said heteroaryl-(C 1 -C 4 )alkylene may be optionally substituted by one or more -(C 1 -C 4 )alkyl groups; R d is -H or -(C 1 -C 4 )alkyl; R e is -H or -(C 1 -C 4 )alkyl; R 7 is -H or -(C 1 -C 4 )alkyl; R 8 is -H or -(C 1 -C 4 )alkyl; R 9 is selected from the group consisting of heterocycloalkyl, heterocycloalkyl-(Ci-C4)alkylene-, (C 1 -C 4 )alkylene-NR d R e and (C 1 -C 4 )alkylene-N + R a R b R c ; R 10 is -H or -(C 1 -C 4 )alkyl; wherein any of such heterocycloalkyl, aryl, heteroaryl and aryl-(C 1 -C 4 )alkylene may be optionally substituted by one or more groups independently selected from (C 1 -C 4 )alkyl and OR 7 and wherein the nitrogen atom in the heterocycloalkyl and heteroaryl groups may be quaternized.
An effective amount of an RNAi agent for use in treating a subject having or at risk for a disease characterized or caused by a gain-of-function mutant protein, wherein the RNAi agent is capable of targeting an allelic polymorphism within a gene encoding said mutant protein such that sequence-specific interference of said gene occurs, wherein the gain-of-function mutant protein is huntingtin and the disease is Huntington's disease, and wherein the RNAi agent is an engineered RNA precursor, or an expression construct engineered to express an engineered RNA precursor, and wherein the polymorphic region targeted by the RNAi agent is distinct from the expanded CAG region mutation of the gene.
A method for manufacturing a coated product in which a surface and a side surface of a substrate are coated with a decorative material , the method comprising: a transport step of transporting a laminate in which the decorative material is bonded to the surface of the substrate ; a heating step of heating a bending margin of the decorative material projecting outward from the side surface of the substrate ; and a bonding step of bending the bending margin heated in the heating step to bond the bending margin to the side surface of the substrate , wherein, in the heating step, the bending margin being heated is bent in a half-folded state toward the side surface of the substrate , and wherein, in the bonding step, the bending margin bent in the half-folded state in the heating step is further bent to be bonded to the side surface of the substrate , characterized in that the heating of the bending margin in the heating step is done during transport of the laminate ; and in that the bending of the bending margin in the bonding step is done during transport of the laminate in a non-heated state, in which the bending margin is not affected by a heater such that it is not heated. a transport step of transporting a laminate in which the decorative material is bonded to the surface of the substrate ; a heating step of heating a bending margin of the decorative material projecting outward from the side surface of the substrate ; and a bonding step of bending the bending margin heated in the heating step to bond the bending margin to the side surface of the substrate , wherein, in the heating step, the bending margin being heated is bent in a half-folded state toward the side surface of the substrate , and wherein, in the bonding step, the bending margin bent in the half-folded state in the heating step is further bent to be bonded to the side surface of the substrate , characterized in that the heating of the bending margin in the heating step is done during transport of the laminate ; and in that the bending of the bending margin in the bonding step is done during transport of the laminate in a non-heated state, in which the bending margin is not affected by a heater such that it is not heated.
Induction cooker comprising: a cooking surface , a coil that is arranged under the cooking surface , a power electronics circuit that is electrically coupled to the coil for driving the coil with a high frequency electric current, a movement arrangement that is coupled to the coil and that is configured to controllably move the coil towards the cooking surface and away from the cooking surface , characterised by a fluid conduction arrangement that is filled with a fluid and that is thermally coupled to the power electronics circuit and that is mechanically coupled to the movement arrangement such that a volume of the fluid controls the movement of the movement arrangement . a cooking surface , a coil that is arranged under the cooking surface , a power electronics circuit that is electrically coupled to the coil for driving the coil with a high frequency electric current, a movement arrangement that is coupled to the coil and that is configured to controllably move the coil towards the cooking surface and away from the cooking surface , characterised by a fluid conduction arrangement that is filled with a fluid and that is thermally coupled to the power electronics circuit and that is mechanically coupled to the movement arrangement such that a volume of the fluid controls the movement of the movement arrangement .
A method, comprising: identifying traffic with Quality of Service, QoS, priority for a first station, STA, 120a of a plurality connected STAs; in response to determining that the first STA is capable of full-duplex communication, creating a virtual STA device associated with the first STA; allocating a plurality of Resource Units, RU, to the plurality of connected STAs based on communications capabilities and traffic requests corresponding to the plurality of connected STAs, wherein a first RU of the plurality of RUs is allocated to a first STA of the plurality of connected STAs as a downlink, DL, RU, and a second RU of the plurality of RUs is allocated to the virtual device as an uplink, UL, RU; re-assigning the second RU from the virtual device to the first STA as a bidirectional, BD, RU for full-duplex communications with the first STA; transmitting a generalized-trigger to the plurality of connected STAs to assign the plurality of RUs; transmitting downlink, DL, communications on DL RUs of the plurality RUs and the second RU; and receiving uplink, UL, communications on UL RUs of the plurality of RUs and the second RU. identifying traffic with Quality of Service, QoS, priority for a first station, STA, 120a of a plurality connected STAs; in response to determining that the first STA is capable of full-duplex communication, creating a virtual STA device associated with the first STA; allocating a plurality of Resource Units, RU, to the plurality of connected STAs based on communications capabilities and traffic requests corresponding to the plurality of connected STAs, wherein a first RU of the plurality of RUs is allocated to a first STA of the plurality of connected STAs as a downlink, DL, RU, and a second RU of the plurality of RUs is allocated to the virtual device as an uplink, UL, RU; re-assigning the second RU from the virtual device to the first STA as a bidirectional, BD, RU for full-duplex communications with the first STA; transmitting a generalized-trigger to the plurality of connected STAs to assign the plurality of RUs; transmitting downlink, DL, communications on DL RUs of the plurality RUs and the second RU; and receiving uplink, UL, communications on UL RUs of the plurality of RUs and the second RU.
A method comprising: receiving information associated with operational states of a plurality of apparatuses, wherein each of the apparatuses comprises: a controller ; memory accessible to the controller ; a bus operatively coupled to the controller ; and sensor circuitry operatively coupled to the bus , wherein the sensor circuitry generates measurement information representative of an environmental condition; generating a predictive model based at least in part on the information ; and deriving codes based at least in part on the predictive model, wherein each of the codes corresponds to an apparatus-detectable individual operational state, wherein the predictive model is or comprises a virtual machine of the apparatus, the method further comprising: using the virtual machine with accelerated time so that the virtual machine performs actions that may establish states as possible states of the apparatus; and upon detecting a possible state of the apparatus that may be problematic, taking one or more corrective actions. receiving information associated with operational states of a plurality of apparatuses, wherein each of the apparatuses comprises: a controller ; memory accessible to the controller ; a bus operatively coupled to the controller ; and sensor circuitry operatively coupled to the bus , wherein the sensor circuitry generates measurement information representative of an environmental condition; a controller ; memory accessible to the controller ; a bus operatively coupled to the controller ; and sensor circuitry operatively coupled to the bus , wherein the sensor circuitry generates measurement information representative of an environmental condition; generating a predictive model based at least in part on the information ; and deriving codes based at least in part on the predictive model, wherein each of the codes corresponds to an apparatus-detectable individual operational state, wherein the predictive model is or comprises a virtual machine of the apparatus, the method further comprising: using the virtual machine with accelerated time so that the virtual machine performs actions that may establish states as possible states of the apparatus; and upon detecting a possible state of the apparatus that may be problematic, taking one or more corrective actions. using the virtual machine with accelerated time so that the virtual machine performs actions that may establish states as possible states of the apparatus; and upon detecting a possible state of the apparatus that may be problematic, taking one or more corrective actions.
A stoker type incinerator for combusting objects (T) to be incinerated, comprising: a drying stage , a combustion stage and a post-combustion stage , each of the stages having a plurality of fixed fire grates and a plurality of movable fire grates , and in which the objects (T) to be incinerated supplied from a feeder are subjected to drying, combustion and post-combustion while sequentially conveying the objects (T) to be incinerated through the drying stage , the combustion stage and the post-combustion stage , wherein the drying stage is disposed to be inclined so that a downstream side in a conveying direction is directed downward, the combustion stage is connected to the drying stage and disposed to be inclined so that the downstream side end thereof in the conveying direction is directed upward, and the post-combustion stage is connected to the combustion stage and disposed to be inclined so that the downstream side end thereof in the conveying direction is directed upward. a drying stage , a combustion stage and a post-combustion stage , each of the stages having a plurality of fixed fire grates and a plurality of movable fire grates , and in which the objects (T) to be incinerated supplied from a feeder are subjected to drying, combustion and post-combustion while sequentially conveying the objects (T) to be incinerated through the drying stage , the combustion stage and the post-combustion stage , wherein the drying stage is disposed to be inclined so that a downstream side in a conveying direction is directed downward, the combustion stage is connected to the drying stage and disposed to be inclined so that the downstream side end thereof in the conveying direction is directed upward, and the post-combustion stage is connected to the combustion stage and disposed to be inclined so that the downstream side end thereof in the conveying direction is directed upward.
Support structure for a non-driven commercial vehicle, in particular a trailer that can be or is coupled to a tractor unit, comprising: - a number of main side member elements , - a number of crossmember elements , - a number of auxiliary side member elements that are arranged on the main side member elements , in particular so as to extend in parallel with the main side member elements , wherein - at least one auxiliary side member element is formed having at least one receiving region for receiving at least one crossmember element in portions, or comprises at least one receiving region of this kind, - at least one receiving region of at least one auxiliary side member element is designed so as to be open on one side, - the receiving region is formed by a U-shaped recess , open on one side, in the auxiliary side member element , - the recess is oriented towards a substrate when the support structure is in the assembled state, - at least the auxiliary side member elements are formed as profile-like structural elements, characterised in that the dimensions of the recess are adjusted to the dimensions of the crossmember element , such that the crossmember element passes through the recess in the transverse direction. - a number of main side member elements , - a number of crossmember elements , - a number of auxiliary side member elements that are arranged on the main side member elements , in particular so as to extend in parallel with the main side member elements , wherein - at least one auxiliary side member element is formed having at least one receiving region for receiving at least one crossmember element in portions, or comprises at least one receiving region of this kind, - at least one receiving region of at least one auxiliary side member element is designed so as to be open on one side, - the receiving region is formed by a U-shaped recess , open on one side, in the auxiliary side member element , - the recess is oriented towards a substrate when the support structure is in the assembled state, - at least the auxiliary side member elements are formed as profile-like structural elements,
Spacecraft comprising a body having at least one face , at least one radiator carried by said face , and at least one thermal insulation device capable of thermally insulating the body from the space environment; said thermal insulation device comprising at least one flexible insulating sheet that is movable between an unfolded position in which the flexible sheet covers a coverable area of the radiator, and a position folded on itself in which said coverable area of the radiator is exposed to the space environment, characterized in that the flexible sheet comprises multiple pleats which extend perpendicularly to the direction of movement of the flexible sheet , said pleats being folded against one another when the flexible sheet is in the folded position, said pleats being spaced apart from one another when the flexible sheet is in an unfolded position.
A heterodimeric antibody comprising: a) a first heavy chain comprising: i) a first Fc domain variant; ii) a single chain Fv region (scFv) that binds CD3; and b) a second heavy chain comprising: i) a second Fc domain variant; and ii) a first variable heavy domain; and c) a first light chain comprising a first variable light domain and a first constant light domain; wherein said first variable heavy domain and said first variable light domain bind to CD38, and wherein said second heavy chain and said first light chain are selected from the pairs consisting of a) a first heavy chain comprising: i) a first Fc domain variant; ii) a single chain Fv region (scFv) that binds CD3; and i) a first Fc domain variant; ii) a single chain Fv region (scFv) that binds CD3; and b) a second heavy chain comprising: i) a second Fc domain variant; and ii) a first variable heavy domain; and i) a second Fc domain variant; and ii) a first variable heavy domain; and c) a first light chain comprising a first variable light domain and a first constant light domain;
Plug-in connector part , comprising - a plug-in section for plug-connection to an associated mating plug-in connector part and - at least one contact element which is arranged on the plug-in section and has at least one electrically conductive contact section for plug-connection to an associated mating contact element of the mating plug-in connector part and one shaft section , which adjoins the contact section , for fastening an electrical line to the contact element , characterized by a sleeve element which can be attached to the shaft section of the at least one contact element and has a body , a plug-in opening , which is formed in the body , for receiving the shaft section , and a cooling duct , which is formed in or on the body and extends around the plug-in opening , for conducting a coolant. - a plug-in section for plug-connection to an associated mating plug-in connector part and - at least one contact element which is arranged on the plug-in section and has at least one electrically conductive contact section for plug-connection to an associated mating contact element of the mating plug-in connector part and one shaft section , which adjoins the contact section , for fastening an electrical line to the contact element ,