A stimulation therapy system comprising: - a stimulation device such as a pulse generator connected to one or more electrodes suitable for placement on or near a nerve of the vegetative nervous system; - an external communication device capable of communicating with the pulse generator; - at least one physiological and/or physical signal generator and signal processing units capable of providing at least one current physiological/ physical level (currentPVL); and - means for controlling the stimulation device according to a set of stimulation parameters; characterised in that it comprises: - means for controlling its stimulation by means of a state transition model comprising a transition matrix (T) and a connection matrix (C) capable of applying optimal stimulation parameters in order to reduce the current physiological/physical level to a determined target level (target PVL), wherein the states (Si) of the model are characterised by a set of stimulation parameter values (Pi) and at least one expected physiological-physical response (RSi) in the application of stimulation with said parameters (Pi), - means for self-adaptation of the state transition model, including: - means for storing the successive physiological/physical levels actually attained during delivery of the respective stimulation sets; - means for adjusting said at least one expected response (RSi) associated with said set of stimulation parameters (i) according to physiological or physical levels actually achieved during stimulation with said set of stimulation parameters (i); and - means for ordering the states according to the new values of the characteristic reponses (RSi). - a stimulation device such as a pulse generator connected to one or more electrodes suitable for placement on or near a nerve of the vegetative nervous system; - an external communication device capable of communicating with the pulse generator; - at least one physiological and/or physical signal generator and signal processing units capable of providing at least one current physiological/ physical level (currentPVL); and - means for controlling the stimulation device according to a set of stimulation parameters; - means for controlling its stimulation by means of a state transition model comprising a transition matrix (T) and a connection matrix (C) capable of applying optimal stimulation parameters in order to reduce the current physiological/physical level to a determined target level (target PVL), wherein the states (Si) of the model are characterised by a set of stimulation parameter values (Pi) and at least one expected physiological-physical response (RSi) in the application of stimulation with said parameters (Pi), - means for self-adaptation of the state transition model, including: - means for storing the successive physiological/physical levels actually attained during delivery of the respective stimulation sets; - means for adjusting said at least one expected response (RSi) associated with said set of stimulation parameters (i) according to physiological or physical levels actually achieved during stimulation with said set of stimulation parameters (i); and - means for ordering the states according to the new values of the characteristic reponses (RSi). - means for storing the successive physiological/physical levels actually attained during delivery of the respective stimulation sets; - means for adjusting said at least one expected response (RSi) associated with said set of stimulation parameters (i) according to physiological or physical levels actually achieved during stimulation with said set of stimulation parameters (i); and - means for ordering the states according to the new values of the characteristic reponses (RSi). <EOS>