A control device for controlling the administration of propofol to a patient comprising - a human machine interface , - an infusion pump which comprises a controller for computing a recommended infusion rate for administering propofol to the patient , and - a depth-of-anesthesia monitor , - a target setting unit for setting a BIS target, - wherein the controller comprises a model unit for computing the recommended infusion rate to achieve the BIS target, by using the model unit for determining the propofol sensitivity of a patient by means of a mathematical model taking into account the bispectral index BIS, wherein the mathematical model comprises a PK/PD model and wherein the estimation of the sensitivity of a patient to an anesthetic is based on a PK/PD model, which comprises a 3+1 PK/PD model with compartments, a remote compartment X and a BIS sensor compartment S, wherein the remote compartment X models the delay between the propofol concentration in an effect-site compartment and its actual impact on the BIS value, characterised in that the compartment S is calculated according to the following equation: S = s p X α _ M + X − k b 0 S + OF wherein s p represents the propofol sensitivity of the patient; α M represents the saturation parameters of the velocity of effect of an anesthetic; k b0 represents the decay rate of the BIS index; OF represents the offset that can remain when no more anesthetic is present in the patient body; X represents a remote compartment; and S represents a BIS sensor - a human machine interface , - an infusion pump which comprises a controller for computing a recommended infusion rate for administering propofol to the patient , and - a depth-of-anesthesia monitor , - a target setting unit for setting a BIS target, - wherein the controller comprises a model unit for computing the recommended infusion rate to achieve the BIS target, by using the model unit for determining the propofol sensitivity of a patient by means of a mathematical model taking into account the bispectral index BIS, wherein the mathematical model comprises a PK/PD model and wherein the estimation of the sensitivity of a patient to an anesthetic is based on a PK/PD model, which comprises a 3+1 PK/PD model with compartments, a remote compartment X and a BIS sensor compartment S, wherein the remote compartment X models the delay between the propofol concentration in an effect-site compartment and its actual impact on the BIS value, characterised in that the compartment S is calculated according to the following equation: S = s p X α _ M + X − k b 0 S + OF wherein s p represents the propofol sensitivity of the patient; α M represents the saturation parameters of the velocity of effect of an anesthetic; k b0 represents the decay rate of the BIS index; OF represents the offset that can remain when no more anesthetic is present in the patient body; X represents a remote compartment; and S represents a BIS sensor s p represents the propofol sensitivity of the patient; α M represents the saturation parameters of the velocity of effect of an anesthetic; k b0 represents the decay rate of the BIS index; OF represents the offset that can remain when no more anesthetic is present in the patient body; X represents a remote compartment; and S represents a BIS sensor <EOS>