Compound of the formula II or pharmaceutically usable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios, wherein: X is H or CH 3 or NH 2 , Y is absent, B is N or CH, E is NH 2 or H, W is NR, or O, Z is, independently, CH 2 , CH 2 -CH 2 , NH or is absent, "linker" is a group selected from an aryl ring, heteroaryl ring, a 4-7 membered saturated or partially unsaturated heterocycle having 1-3 heteroatoms independently selected from nitrogen, or oxygen, or a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, or oxygen, or a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms attached to a hetero saturated ring, cycloalkanes optionally substituted with OH, A is a monocyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, and/or O atoms and 5, 6, 7, 8, 9, or 10 skeleton C atoms, Hal is F, Cl, Br or I, R is independently hydrogen, oxygen or a group selected from C 1-6 linear aliphatic, a 4-7 membered heterocylic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or a mono- or bicyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, O atoms and 5, 6, 7, or 8 C skeleton atoms, which may be unsubstituted or, independently of one another, mono-, di- or trisubstituted by Hal, A, OH, NH 2 , nitrile, and/or C(Hal) 3 or is an unbranched or branched linear alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or by an -NH-, -CO-, -NHCOO-, -NHCONH-, -CONH-, -NHCO- or-CH=CH- group, and in which 1-3 H atoms may be replaced by Hal, R q is selected from --R, --A, halogen, --OR, --O(CH 2 ) r OR, -R(NH),-NO 2 , --C(O)R, --CO 2 R, --C(O)N(R) 2 , --NRC(O)R, --NRC(O)NR 2 ,-NRSO 2 R, or --N(R) 2 , r is 1-4, n is 0-4, and Q is X is H or CH 3 or NH 2 , Y is absent, B is N or CH, E is NH 2 or H, W is NR, or O, Z is, independently, CH 2 , CH 2 -CH 2 , NH or is absent, "linker" is a group selected from an aryl ring, heteroaryl ring, a 4-7 membered saturated or partially unsaturated heterocycle having 1-3 heteroatoms independently selected from nitrogen, or oxygen, or a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, or oxygen, or a 7-10 membered bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms attached to a hetero saturated ring, cycloalkanes optionally substituted with OH, A is a monocyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, and/or O atoms and 5, 6, 7, 8, 9, or 10 skeleton C atoms, Hal is F, Cl, Br or I, R is independently hydrogen, oxygen or a group selected from C 1-6 linear aliphatic, a 4-7 membered heterocylic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or a mono- or bicyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N, O atoms and 5, 6, 7, or 8 C skeleton atoms, which may be unsubstituted or, independently of one another, mono-, di- or trisubstituted by Hal, A, OH, NH 2 , nitrile, and/or C(Hal) 3 or is an unbranched or branched linear alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or by an -NH-, -CO-, -NHCOO-, -NHCONH-, -CONH-, -NHCO- or-CH=CH- group, and in which 1-3 H atoms may be replaced by Hal, R q is selected from --R, --A, halogen, --OR, --O(CH 2 ) r OR, -R(NH),-NO 2 , --C(O)R, --CO 2 R, --C(O)N(R) 2 , --NRC(O)R, --NRC(O)NR 2 ,-NRSO 2 R, or --N(R) 2 , r is 1-4, n is 0-4, and Q is <EOS>