mhurhangee/patent-ind-claim-en huggingface dataset:
A method for optimizing dosing amounts and/or schedules of a compound in a transgenic mouse whose genome comprises a nucleic acid encoding human cereblon (CRBN) or a functional fragment thereof, wherein the functional fragment exhibits the ability of native human CRBN to form an E3 ubiquitin-ligase complex and mediates the ubiquitination and subsequent proteosomal degradation of target proteins, wherein the mouse expresses the human CRBN or functional fragment thereof and does not express endogenous mouse CRBN, the method comprising the steps of: (a) administering the compound to the transgenic mouse; (b) obtaining a sample from the transgenic mouse; (c) measuring the level of a biomarker in the sample; and (d) adjusting the dosing amount and/or schedule of the compound based on the level of the biomarker; wherein the biomarker is a CRBN-associated protein (CAP). wherein the functional fragment exhibits the ability of native human CRBN to form an E3 ubiquitin-ligase complex and mediates the ubiquitination and subsequent proteosomal degradation of target proteins, wherein the mouse expresses the human CRBN or functional fragment thereof and does not express endogenous mouse CRBN, the method comprising the steps of: (a) administering the compound to the transgenic mouse; (b) obtaining a sample from the transgenic mouse; (c) measuring the level of a biomarker in the sample; and (d) adjusting the dosing amount and/or schedule of the compound based on the level of the biomarker; (a) administering the compound to the transgenic mouse; (b) obtaining a sample from the transgenic mouse; (c) measuring the level of a biomarker in the sample; and (d) adjusting the dosing amount and/or schedule of the compound based on the level of the biomarker; wherein the biomarker is a CRBN-associated protein (CAP).
A cathode sputtering target formed, on the one hand, from an oxide of at least one element chosen from the group of titanium, silicon and zirconium and, on the other hand, of particles of a metal included in the group formed by silver, gold, platinum, copper and nickel or particles of an alloy formed from at least two of these metals, the M/Me atomic ratio in said target being less than 0.9, M representing all of the atoms of the elements of the group of titanium, silicon and zirconium and Me representing all of the atoms of the metals of the group formed by silver, gold, platinum, copper and nickel.
A touch sensor with a board carrier for surface mounting, a printed circuit board arranged on the board carrier , on which at least two switching elements are arranged, and with at least one rocker switch for actuating the switching elements , the touch sensor having at least one reset element which is arranged between the board carrier and the rocker switch and by means of which the rocker switch is biased out of an actuating position, in which the rocker switch actuates at least one of the switching elements , into a rest position, in which the rocker switch does not actuate any of the switching elements , the rocker switch being mounted such that it can be pivoted about a swivel axis (x) with respect to which the at least two switching elements are arranged opposite one another, characterized in that the rocker switch has a form-fit adapter on its side facing the board , in which the reset element is received in a form-fitting manner, and the form-fit adapter having a first and a second boundary wall which extend at a distance from one another and at least in sections perpendicularly to the swivel axis (x) and parallel to the printed circuit board and from an underside of the rocker switch .
A method of tracking a moving object , the method being performed by a processor, and the method comprising: determining a heading angle of a velocity vector of a centroid of the object from a tracking device ; determining a raw difference value corresponding to a difference between a pointing angle of a selected feature on the object and the heading angle , wherein the raw difference value is based on a trajectory curvature of the centroid from the tracking device and a distance between the centroid and the selected feature ; determining a filtered difference between the pointing angle and the heading angle using a low pass filter by: determining a plurality of the raw difference values; and filtering the plurality of raw difference values to remove noise from the raw difference values; and determining the pointing angle by subtracting the filtered difference from the heading angle . determining a heading angle of a velocity vector of a centroid of the object from a tracking device ; determining a raw difference value corresponding to a difference between a pointing angle of a selected feature on the object and the heading angle , wherein the raw difference value is based on a trajectory curvature of the centroid from the tracking device and a distance between the centroid and the selected feature ; determining a filtered difference between the pointing angle and the heading angle using a low pass filter by: determining a plurality of the raw difference values; and filtering the plurality of raw difference values to remove noise from the raw difference values; and determining a plurality of the raw difference values; and filtering the plurality of raw difference values to remove noise from the raw difference values; and determining the pointing angle by subtracting the filtered difference from the heading angle .
An apparatus for determining pin placement in a femur head, the apparatus comprising a mold including a contoured contact surface for contacting the femur head and defining a first aperture configured to guide a drill bit at the desired location and angle; characterised in that the mold is formed from data indicative of a shape of the femur head so that the contoured contact surface is adapted to fit on an exposed portion of the femur head in a unique position.
A deposit for a toilet for purifying toilet water from one or more environmentally hazardous organic substances, such as drug molecules, comprising one or more enzymes having the ability to eliminate said environmentally hazardous substances, wherein the deposit is designed to be attached to the toilet in such a way that it will release the one or more enzymes upon exposure to toilet flushing water, thereby allowing the one or more enzymes to enter the water in the toilet bowl and eliminate environmentally hazardous substances that are present in said toilet bowl, characterized in that the one or more enzymes are chosen from the group comprising of Epoxide hydrolase, Melamine Deaminase, Acetoacetate decarboxylase and Dehalogenase LinB.
Filter unit , including: at least one knitted spacer fabric , comprising a first and a second cover layer (4; 5) each having a plurality of openings delimited by edge regions , threads extending from the edge regions of the first cover layer to edge regions of the second cover layer , and the at least one knitted spacer fabric being rolled and being compressed at least in a portion in a direction transverse to the cover layers thereof, the filter unit including the at least one knitted spacer fabric as a filter body , the filter unit including a recess for receiving the knitted spacer fabric as a filter body , wherein the recess includes a fluid inlet at one end for guiding fluid to be filtered to the at least one knitted spacer fabric and for flowing through the at least one knitted spacer fabric in a longitudinal direction along the cover layers thereof and the threads extending between them, and wherein the recess includes a fluid outlet at an opposite end for subsequently discharging the fluid filtered through the at least one knitted spacer fabric , wherein the recess is configured in such a way that the at least one rolled knitted spacer fabric received in the recess is compressed in at least one portion in the direction transverse to the cover layers thereof. at least one knitted spacer fabric , comprising a first and a second cover layer (4; 5) each having a plurality of openings delimited by edge regions , threads extending from the edge regions of the first cover layer to edge regions of the second cover layer , and the at least one knitted spacer fabric being rolled and being compressed at least in a portion in a direction transverse to the cover layers thereof, the filter unit including the at least one knitted spacer fabric as a filter body , the filter unit including a recess for receiving the knitted spacer fabric as a filter body , wherein the recess includes a fluid inlet at one end for guiding fluid to be filtered to the at least one knitted spacer fabric and for flowing through the at least one knitted spacer fabric in a longitudinal direction along the cover layers thereof and the threads extending between them, and wherein the recess includes a fluid outlet at an opposite end for subsequently discharging the fluid filtered through the at least one knitted spacer fabric , wherein the recess is configured in such a way that the at least one rolled knitted spacer fabric received in the recess is compressed in at least one portion in the direction transverse to the cover layers thereof.
A communication method in a communication network comprising a plurality of nodes, at least one node comprising a plurality of access categories, ACs, for serving data traffic at different priorities the method comprising, at the node: computing, for each AC, an associated queue backoff value from contention parameters, using each backoff value associated with each AC to contend for access to a communication channel in order to transmit data stored in the respective AC in an enhanced distributed channel access, EDCA, transmission opportunity, TXOP; the method further comprising, at the node: using a plurality of timers, each one associated with one of the ACs, each timer counting down a predetermined duration, during which the contention parameters remain set to MU-EDCA parameters for the corresponding AC, and at an expiry of which the contention parameters are set back to EDCA parameters different from the MU-EDCA parameters, wherein the contention parameters for an AC are set to the MU-EDCA parameters for the corresponding predetermined duration upon transmitting data stored in the AC over one or more accessed resource units provided by another node within one or more transmission opportunities granted to the other node on the communication channel. computing, for each AC, an associated queue backoff value from contention parameters, using each backoff value associated with each AC to contend for access to a communication channel in order to transmit data stored in the respective AC in an enhanced distributed channel access, EDCA, transmission opportunity, TXOP; the method further comprising, at the node: using a plurality of timers, each one associated with one of the ACs, each timer counting down a predetermined duration, during which the contention parameters remain set to MU-EDCA parameters for the corresponding AC, and at an expiry of which the contention parameters are set back to EDCA parameters different from the MU-EDCA parameters, wherein the contention parameters for an AC are set to the MU-EDCA parameters for the corresponding predetermined duration upon transmitting data stored in the AC over one or more accessed resource units provided by another node within one or more transmission opportunities granted to the other node on the communication channel. using a plurality of timers, each one associated with one of the ACs, each timer counting down a predetermined duration, during which the contention parameters remain set to MU-EDCA parameters for the corresponding AC, and at an expiry of which the contention parameters are set back to EDCA parameters different from the MU-EDCA parameters, wherein the contention parameters for an AC are set to the MU-EDCA parameters for the corresponding predetermined duration upon transmitting data stored in the AC over one or more accessed resource units provided by another node within one or more transmission opportunities granted to the other node on the communication channel.
A golf bag , comprising a front panel and a back panel having therebetween a bundle of shaft receptacles for therein receiving a golf club by the shaft thereof, wherein front and back panel are pivotably connected with each other at a bottom of the golf bag , and are adjustable relative to each other between a collapsed, substantially flat position (I) in which front and back panel run substantially along each other, and a folded-out, substantially wedge-shaped position (II) in which front and back panel diverge and in which between their free ends a presentation surface is located in which the shaft receptacles terminate and with mutual spacing are grouped in rows which run along each other with an intermediate distance, so that golf clubs whose shaft is received in a shaft receptacle have their heads positioned on the presentation surface in rows spaced apart with an intermediate distance, wherein the shaft receptacles are manufactured from flexible material.
A sex toy for insertion into the body of a wearer and a partner at the same time, comprising: (a) a first elongated, resilient, and generally cylindrical rear end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions ; (b) a second elongated, resilient, and generally cylindrical front end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions ; and (c) a centre region , wherein said first and said second end regions connect with opposing ends of said centre region , characterised by a means for attaching attached to a point of attachment on said centre region , wherein said means for attaching is capable of going around the wearer's penis or a strap on dildo worn by the wearer with said rear end region received in the wearer's anus and the front end region inserted in the partner's anus or vagina to enable simultaneous anal penetration of the wearer while performing anal or vaginal intercourse with the partner and said means for attaching and said point of attachment create a fulcrum or pivot point for transferring kinetic energy from one of said end regions to the other of said end regions . (a) a first elongated, resilient, and generally cylindrical rear end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions ; (b) a second elongated, resilient, and generally cylindrical front end region sized for receipt in an anal or vaginal cavity and having proximate and distal end portions ; and (c) a centre region , wherein said first and said second end regions connect with opposing ends of said centre region , characterised by a means for attaching attached to a point of attachment on said centre region , wherein said means for attaching is capable of going around the wearer's penis or a strap on dildo worn by the wearer with said rear end region received in the wearer's anus and the front end region inserted in the partner's anus or vagina to enable simultaneous anal penetration of the wearer while performing anal or vaginal intercourse with the partner and said means for attaching and said point of attachment create a fulcrum or pivot point for transferring kinetic energy from one of said end regions to the other of said end regions .
A superconducting magnet comprising: a liquid helium reservoir ; superconducting magnet windings disposed in the liquid helium reservoir ; a vacuum jacket surrounding the liquid helium reservoir ; a cold head passing through the vacuum jacket , the cold head having a warm end welded to an outer wall of the vacuum jacket and a cold station disposed in the liquid helium reservoir ; and a heat exchanger disposed inside the vacuum jacket and secured to or integral with the cold head , characterized in that the heat exchanger includes a fluid passage having an inlet in fluid communication with the liquid helium reservoir and has an outlet in fluid communication with ambient air. a liquid helium reservoir ; superconducting magnet windings disposed in the liquid helium reservoir ; a vacuum jacket surrounding the liquid helium reservoir ; a cold head passing through the vacuum jacket , the cold head having a warm end welded to an outer wall of the vacuum jacket and a cold station disposed in the liquid helium reservoir ; and a heat exchanger disposed inside the vacuum jacket and secured to or integral with the cold head , characterized in that the heat exchanger includes a fluid passage having an inlet in fluid communication with the liquid helium reservoir and has an outlet in fluid communication with ambient air.
A method, performed by a wireless device , for managing radio link failures, "RLF", of the wireless device when the wireless device is served by a wireless communication network , a first, default, RLF procedure being associated with at least a first type of wireless devices supported by the wireless communication network , wherein the method comprises: - obtaining (305; 501) information indicative of a second RLF procedure based on that the wireless device is of a second type having an improved radio coverage capability compared to the first type, wherein the obtained information comprises one or more configuration parameters that configures the wireless device to apply the second RLF procedure and to generate, for coverage hole detection, a measurement report according to the first RLF procedure while applying the second RLF procedure; - applying (306; 502), based on the obtained information, said second RLF procedure, wherein the first and second RLF procedures apply first and second time periods, respectively, from when the wireless device is considered to be out-of-sync until the wireless device is considered to be in a state of RLF, which second time period is longer than the first time period, and - generating (307; 503) the measurement report based on the obtained information and the first RLF procedure for coverage hole detection when criteria based on the values associated with the first RLF procedure are fulfilled. - obtaining (305; 501) information indicative of a second RLF procedure based on that the wireless device is of a second type having an improved radio coverage capability compared to the first type, wherein the obtained information comprises one or more configuration parameters that configures the wireless device to apply the second RLF procedure and to generate, for coverage hole detection, a measurement report according to the first RLF procedure while applying the second RLF procedure; - applying (306; 502), based on the obtained information, said second RLF procedure, wherein the first and second RLF procedures apply first and second time periods, respectively, from when the wireless device is considered to be out-of-sync until the wireless device is considered to be in a state of RLF, which second time period is longer than the first time period, and - generating (307; 503) the measurement report based on the obtained information and the first RLF procedure for coverage hole detection when criteria based on the values associated with the first RLF procedure are fulfilled.
A method for measuring a mechanical property of an object using an ultrasound system having a transducer, the steps of the method comprising: (a) providing a continuous vibration to the ultrasound transducer via a mechanical actuator, whereby vibration of the ultrasound transducer induces at least one shear wave in the object; (b) acquiring motion data from the object using the ultrasound transducer, wherein the motion data are indicative of the at least one shear wave propagating within the object; (c) estimating a compression profile indicative of a deformation of the object caused by the continuous vibration of the ultrasound transducer; (d) producing corrected data by separating the compression profile from the acquired motion data; (e) processing the corrected data to calculate a mechanical property of the object; characterised in that the compression profile is estimated by fitting the acquired motion data to a function that approximates the deformation of the object caused by the continuous vibration of the ultrasound transducer. (a) providing a continuous vibration to the ultrasound transducer via a mechanical actuator, whereby vibration of the ultrasound transducer induces at least one shear wave in the object; (b) acquiring motion data from the object using the ultrasound transducer, wherein the motion data are indicative of the at least one shear wave propagating within the object; (c) estimating a compression profile indicative of a deformation of the object caused by the continuous vibration of the ultrasound transducer; (d) producing corrected data by separating the compression profile from the acquired motion data; (e) processing the corrected data to calculate a mechanical property of the object; characterised in that the compression profile is estimated by fitting the acquired motion data to a function that approximates the deformation of the object caused by the continuous vibration of the ultrasound transducer.
Acoustic emitter for treating oil and gas wells, taking the form of a cylindrical housing , consisting of two sealed chambers (4;10) and one chamber that communicates with the environment via apertures , one first sealed chamber being filled with air and having sealed electrical lead-ins , while the second sealed chamber is filled with an electrically insulating liquid, characterized in that a magnetostrictive transducer , with a cylindrical core with an electrical winding and end pieces made of resilient material between the cylindrical core and the electrical winding, is placed in the second sealed chamber filled with electrically insulating liquid, wherein the first sealed chamber , that is filled with air, is co-axially surrounded by the second sealed chamber filled with the electrically insulating liquid.
A percussion primer composition obtainable by using a water processing technique, the composition comprising: an explosive consisting essentially of at least one relatively insensitive explosive in the amount of about 5 wt-% to about 40 wt-% of the primer composition; a sensitizer in an amount of about 0 wt-% to about 20 wt-% of the primer composition; fuel particles having an average particle size of about 100 nanometers to about 1500 nanometers and in an amount of about 1 wt-% to about 20 wt-% of the primer composition; an oxidizer; and at least one buffer. an explosive consisting essentially of at least one relatively insensitive explosive in the amount of about 5 wt-% to about 40 wt-% of the primer composition; a sensitizer in an amount of about 0 wt-% to about 20 wt-% of the primer composition; fuel particles having an average particle size of about 100 nanometers to about 1500 nanometers and in an amount of about 1 wt-% to about 20 wt-% of the primer composition; an oxidizer; and at least one buffer.