A device for transferring liquid comprising: a first pipette tip ; a second pipette tip having a different volume than the first pipette tip ; a piston including a stepped profile, a drive rod portion and a free end portion extending from the drive rod portion , the free end portion having a different diameter than the drive rod portion ; a barrel including a barrel body , and a tip , wherein the tip is configured to engage the first pipette tip through a friction fit, and wherein the tip is further configured to engage the second pipette tip through a friction fit, wherein the barrel includes a stepped bore defined by the barrel body , the stepped bore having an axial hole and a coaxial counterbore , the axial hole passing through the tip ; a first seal element between and engaging the barrel and the free end portion ; and a second seal element between and engaging the barrel and the drive rod portion , wherein the piston is disposed within the barrel such that at most one of the first seal element and the second seal element engages between the barrel and the piston , wherein, in a first high volume pipetting mode using the first pipette tip , the device is configured to aspirate a liquid by withdrawing the piston from the barrel such that the free end portion is above and moves away from the axial hole , and to dispense the liquid by inserting the piston into the barrel such that the free end portion moves toward the axial hole , wherein, in a second low volume pipetting mode using the second pipette tip , the device is configured to aspirate a liquid by withdrawing the piston from the barrel such that the free end portion remains in the axial hole , and to dispense the liquid by inserting the piston into the barrel such that the free end portion remains in the axial hole . a first pipette tip ; a second pipette tip having a different volume than the first pipette tip ; a piston including a stepped profile, a drive rod portion and a free end portion extending from the drive rod portion , the free end portion having a different diameter than the drive rod portion ; a barrel including a barrel body , and a tip , wherein the tip is configured to engage the first pipette tip through a friction fit, and wherein the tip is further configured to engage the second pipette tip through a friction fit, wherein the barrel includes a stepped bore defined by the barrel body , the stepped bore having an axial hole and a coaxial counterbore , the axial hole passing through the tip ; a first seal element between and engaging the barrel and the free end portion ; and a second seal element between and engaging the barrel and the drive rod portion , wherein the piston is disposed within the barrel such that at most one of the first seal element and the second seal element engages between the barrel and the piston , wherein, in a first high volume pipetting mode using the first pipette tip , the device is configured to aspirate a liquid by withdrawing the piston from the barrel such that the free end portion is above and moves away from the axial hole , and to dispense the liquid by inserting the piston into the barrel such that the free end portion moves toward the axial hole , wherein, in a second low volume pipetting mode using the second pipette tip , the device is configured to aspirate a liquid by withdrawing the piston from the barrel such that the free end portion remains in the axial hole , and to dispense the liquid by inserting the piston into the barrel such that the free end portion remains in the axial hole . <EOS>