A device , comprising: a plurality of imaging pixels arranged in a spatial pattern; a formation of features disposed over the plurality of imaging pixels ; a first feature of the formation of features , the first feature disposed over a first pixel of the plurality of imaging pixels , a second feature of the formation of features , the second feature disposed over the first pixel and spatially displaced from the first feature ; a first luminophore disposed within or over the first feature ; a second luminophore disposed within or over the second feature ; and a structured illumination source to direct at least a portion of first photons in an illumination pattern to the first feature at a first time, and to direct at least a portion of second photons in the illumination pattern to the second feature at a second time, the second time being different from the first time, the first pixel to selectively receive luminescence emitted by the first luminophore responsive to the portion of the first photons at the first time, and to selectively receive luminescence emitted by the second luminophore responsive to the portion of the second photons at the second time, wherein the structured illumination source includes an interference pattern generator to propagate light defining a multi-beam interference pattern on the formation of features having an interference pattern generator actuator connected to the interference pattern generator to change a positional state or rotational state of the interference pattern generator to cause the multi-beam interference pattern to translate or rotate relative to the formation of features, characterized in that the interference pattern generator includes a two-dimensional transmission phase mask to split a laser beam into a set of interfering beams. a plurality of imaging pixels arranged in a spatial pattern; a formation of features disposed over the plurality of imaging pixels ; a first feature of the formation of features , the first feature disposed over a first pixel of the plurality of imaging pixels , a second feature of the formation of features , the second feature disposed over the first pixel and spatially displaced from the first feature ; a first luminophore disposed within or over the first feature ; a second luminophore disposed within or over the second feature ; and a structured illumination source to direct at least a portion of first photons in an illumination pattern to the first feature at a first time, and to direct at least a portion of second photons in the illumination pattern to the second feature at a second time, the second time being different from the first time, the first pixel to selectively receive luminescence emitted by the first luminophore responsive to the portion of the first photons at the first time, and to selectively receive luminescence emitted by the second luminophore responsive to the portion of the second photons at the second time, wherein the structured illumination source includes an interference pattern generator to propagate light defining a multi-beam interference pattern on the formation of features having an interference pattern generator actuator connected to the interference pattern generator to change a positional state or rotational state of the interference pattern generator to cause the multi-beam interference pattern to translate or rotate relative to the formation of features, characterized in that the interference pattern generator includes a two-dimensional transmission phase mask to split a laser beam into a set of interfering beams. <EOS>