mhurhangee/patent-ind-claim-en huggingface dataset:
A method for identifying tumors with aberrant activity of druggable oncoproteins having a lack of mutations, the method comprising: (a) obtaining a gene expression signature by comparing a patient's test sample to a plurality of samples representing a control phenotype; (b) calculating a regulon enrichment score of each regulon in the gene expression signature by combining a first regulon enrichment score calculated using a one-tail approach and a second regulon enrichment score calculated using a two-tail approach; and (c) calculating a significance value by comparing each regulon enrichment score to a null model, and determining a differential protein activity for each druggable protein of a plurality of druggable proteins; (d) assigning a statistical significance value to the differential activity by comparing a specific sample against a distribution of all available control samples; and (e) prioritizing each druggable protein, including druggable oncoproteins having a lack of mutations, of the plurality of druggable proteins with a statistically significant aberrant activity on an individual patient basis using a predefined significance threshold as potentially relevant pharmacological targets for that specific patient. (a) obtaining a gene expression signature by comparing a patient's test sample to a plurality of samples representing a control phenotype; (b) calculating a regulon enrichment score of each regulon in the gene expression signature by combining a first regulon enrichment score calculated using a one-tail approach and a second regulon enrichment score calculated using a two-tail approach; and (c) calculating a significance value by comparing each regulon enrichment score to a null model, and determining a differential protein activity for each druggable protein of a plurality of druggable proteins; (d) assigning a statistical significance value to the differential activity by comparing a specific sample against a distribution of all available control samples; and (e) prioritizing each druggable protein, including druggable oncoproteins having a lack of mutations, of the plurality of druggable proteins with a statistically significant aberrant activity on an individual patient basis using a predefined significance threshold as potentially relevant pharmacological targets for that specific patient.
A soil detection system for detecting presence of soil on an article , the soil detection system comprising: a scanning unit for scanning the article with a luminescent agent bound to soil present on the article, the luminescent agent emitting luminescent light at a wavelength of visible light, wherein said luminescent agent is a fluorescent agent and emits a fluorescent light as said luminescent light, wherein the scanning unit is moveable over a surface of the article, said scanning unit including: a laser light source for producing a light that is continuously pulsed ON and OFF at a modulation frequency to be incident on the article , wherein the modulation frequency of the light produced by the light source is lower than an emission frequency of an ambient light source incident on the article, a light filter that allows passage of only green light, a detector for detecting electromagnetic radiation emanating from said article that is filtered by the light filter and generating light data corresponding thereto, said detector operating at a frame rate higher than the modulation frequency of the light produced by the light source and a control unit for receiving the light data generated by the detector to determine the presence of soil on the article , said control unit including a display unit for displaying (i) green blinking features that blink on the display unit at the modulation frequency indicative of the soil and (ii) non-blinking features or blinking features that blink on the display unit at frequencies other than the modulation frequency indicative of the ambient light reflected by the article. a laser light source for producing a light that is continuously pulsed ON and OFF at a modulation frequency to be incident on the article , wherein the modulation frequency of the light produced by the light source is lower than an emission frequency of an ambient light source incident on the article, a light filter that allows passage of only green light, a detector for detecting electromagnetic radiation emanating from said article that is filtered by the light filter and generating light data corresponding thereto, said detector operating at a frame rate higher than the modulation frequency of the light produced by the light source and a control unit for receiving the light data generated by the detector to determine the presence of soil on the article , said control unit including a display unit for displaying (i) green blinking features that blink on the display unit at the modulation frequency indicative of the soil and (ii) non-blinking features or blinking features that blink on the display unit at frequencies other than the modulation frequency indicative of the ambient light reflected by the article.
An electric candle comprising: a housing ; a head ; a light source disposed within the head ; a pendulum supporting the light source and the head , the pendulum pivotally coupled to the housing and configured to move the head and the light source relative to the housing ; and a driving device configured to produce pivotal movement of the pendulum to thereby move the head and the light source relative to the housing ; characterised in that the head is a flame-shaped head; and a colour element is positioned over at least part of the light source and disposed within the flame-shaped head , for creating a colour effect in the flame-shaped head when the light source transmits light through the colour element and the flame-shaped head , wherein the colour element is a translucent, tube-shaped sleeve. a housing ; a head ; a light source disposed within the head ; a pendulum supporting the light source and the head , the pendulum pivotally coupled to the housing and configured to move the head and the light source relative to the housing ; and a driving device configured to produce pivotal movement of the pendulum to thereby move the head and the light source relative to the housing ; characterised in that the head is a flame-shaped head; and a colour element is positioned over at least part of the light source and disposed within the flame-shaped head , for creating a colour effect in the flame-shaped head when the light source transmits light through the colour element and the flame-shaped head , wherein the colour element is a translucent, tube-shaped sleeve.
A distance measuring device , comprising at least one detector for optically detecting at least one object , wherein the detector is designed to determine at least one item of geometrical information of the at least one object , the detector comprising an optical sensor having a sensor region , the sensor region comprising a sensor area , wherein the optical sensor is an element which is designed to convert at least one optical signal into at least one electrical signal, wherein the optical sensor comprises a semiconductor detector , wherein the optical sensor is designed to generate at least one sensor signal in a manner dependent on an illumination of the sensor region , wherein the sensor signal, given the same total power of the illumination is dependent on a beam cross section of the illumination on the sensor area , wherein the detector furthermore has at least one evaluation device , wherein the evaluation device is designed to generate at least one item of geometrical information from the sensor signal, in particular at least one item of geometrical information about the illumination and/or the object , wherein the geometrical information comprises at least one item of location information of the object , wherein the evaluation device is designed to determine the geometrical information from at least one predefined relationship between the geometry of the illumination and a relative positioning of the object with respect to the detector , characterized in that the sensor region is exactly one continuous sensor region , wherein the sensor signal is a uniform sensor signal for the entire sensor region .
A testing device for testing a luminescence imaging apparatus , wherein the testing device comprises: a resting surface for resting the testing device on a supporting surface , one or more seats , one or more containers each filled with a liquid comprising at least one luminescence substance, each of the containers being accommodated in a corresponding one of the seats , one or more windows corresponding to the seats being opened in an imaging surface of the testing device opposite the resting surface , each of the windows exposing a part of the corresponding seat for imaging the luminescence substance of a corresponding part of the container accommodated therein being transparent to an excitation light of the luminescence substance and to a luminescence light emitted by the luminescence substance when illuminated by the excitation light, wherein the seats extend along corresponding longitudinal axes from corresponding first ends to corresponding second ends, each of the seats being slanted with respect to the resting surface with the second end closer to the resting surface than the first end and the longitudinal axes of the seats forming an angle of 5-30° with the resting surface , and in that the corresponding windows are spaced apart from the first ends of the seats . a resting surface for resting the testing device on a supporting surface , one or more seats , one or more containers each filled with a liquid comprising at least one luminescence substance, each of the containers being accommodated in a corresponding one of the seats , one or more windows corresponding to the seats being opened in an imaging surface of the testing device opposite the resting surface , each of the windows exposing a part of the corresponding seat for imaging the luminescence substance of a corresponding part of the container accommodated therein being transparent to an excitation light of the luminescence substance and to a luminescence light emitted by the luminescence substance when illuminated by the excitation light, wherein the seats extend along corresponding longitudinal axes from corresponding first ends to corresponding second ends, each of the seats being slanted with respect to the resting surface with the second end closer to the resting surface than the first end and the longitudinal axes of the seats forming an angle of 5-30° with the resting surface , and in that the corresponding windows are spaced apart from the first ends of the seats .
A medical device or medical implement with high lubricity to flesh or biological fluid and/or inhibited nucleation on its surface, the device or implement comprising: a surface comprising an impregnating liquid, and a plurality of micro-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween, wherein said impregnating liquid fills spaces between said solid features, wherein said surface stably contains said impregnating liquid between said solid features, wherein said impregnating liquid is held in place between said plurality of solid features regardless of orientation of said surface, wherein the solid features comprise particles having an average dimension in a range of 1 micron to 50 microns; and optionally wherein the particles are arranged with average spacing of 1 micron to 30 microns between adjacent particles or clusters of particles. a surface comprising an impregnating liquid, and a plurality of micro-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween, wherein said impregnating liquid fills spaces between said solid features, wherein said surface stably contains said impregnating liquid between said solid features, wherein said impregnating liquid is held in place between said plurality of solid features regardless of orientation of said surface, wherein the solid features comprise particles having an average dimension in a range of 1 micron to 50 microns; and optionally wherein the particles are arranged with average spacing of 1 micron to 30 microns between adjacent particles or clusters of particles.
A process for producing a polymer composition comprising at least the steps of a) providing a masterbatch (MB) which comprises at least one water tree retardant (WTR) additive and a carrier polymer, and b) blending the masterbatch obtained from step a) with at least one LDPE polymer (A) to obtain said polymer composition of the invention wherein the total amount of the one or more WTR additive(s) in the MB is more than 0.5 to less than 50 wt%, based on the total amount (wt%) of the MB and a carrier polymer is present in an amount of at least 50 wt% based on the total amount of the MB. a) providing a masterbatch (MB) which comprises at least one water tree retardant (WTR) additive and a carrier polymer, and b) blending the masterbatch obtained from step a) with at least one LDPE polymer (A) to obtain said polymer composition of the invention
A method comprising: forming a substrate scaffold structure for use in the fabrication of a reversibly deformable circuit board , the substrate scaffold structure comprising a predefined waveform topography , the waveform topography of the substrate scaffold structure predefined to facilitate operational reversible deformation of the circuit board ; depositing one or more scaffold-conforming thin film layers on top of the substrate scaffold structure , the one or more scaffold-conforming thin film layers being adapted for use in forming electronic circuit elements of the reversibly deformable circuit board ; wherein the waveform topography comprises a main waveform and a sub-waveform formed on top of the main waveform, and wherein the sub-waveform has a smaller period and amplitude than the main waveform. forming a substrate scaffold structure for use in the fabrication of a reversibly deformable circuit board , the substrate scaffold structure comprising a predefined waveform topography , the waveform topography of the substrate scaffold structure predefined to facilitate operational reversible deformation of the circuit board ; depositing one or more scaffold-conforming thin film layers on top of the substrate scaffold structure , the one or more scaffold-conforming thin film layers being adapted for use in forming electronic circuit elements of the reversibly deformable circuit board ; wherein the waveform topography comprises a main waveform and a sub-waveform formed on top of the main waveform, and wherein the sub-waveform has a smaller period and amplitude than the main waveform.
A composition for use as a bulking agent which is configured to be injected inside a wall of the urethra of a mammal or inside a wall of the rectum of a mammal, in the treatment of urinary or faecal incontinence respectively, the composition comprising a nanostructured cellulosic material, wherein the nanostructured cellulosic material comprises never-dried nanostructured cellulosic material which has been manufactured by a pulping process.
A method for preparing catalysts used for preparing chlorine by oxidizing hydrogen chloride, comprising the steps of: mixing a slurry A with a slurry B under the condition of a mixing temperature being >X°C and ≤100°C, and a residence time being ≤ 120 minutes to obtain a mixed slurry; treating the mixed slurry with spray drying to obtain catalyst precursor particles; and calcining the catalyst precursor particles to obtain the catalysts, wherein, X°C is the highest value among the solidifying points of slurry A, slurry B and the mixed slurry; slurry A is acidic and contains boron and chromium; slurry B contains copper, boron, alkali-metal elements, rare-earth elements, alumina sol, silica sol, carrier and optionally at least one of other metal elements selected from the group consisting of magnesium, calcium, barium, manganese, ruthenium and titanium, wherein, when the mixing temperature is between 50∼100°C, the residence time is ≤10 minutes, preferably 3∼10 minutes; when the mixing temperature is between 30∼50°C, the residence time is ≤30 minutes, preferably 10∼25 minutes; when the mixing temperature is >X°C and ≤30°C, the residence time is ≤120 minutes, preferably 20∼100 minutes, more preferably 40∼70 minutes; wherein the total content of iron and nickel in the mixed slurry after the mixing of slurry A and slurry B is ≤0.05wt%, preferably ≤0.02wt%, based on the total weight of the mixed slurry; and wherein the content of elemental sulphur in the mixed slurry after the mixing of slurry A and slurry B is ≤0.05wt%, preferably ≤0.02wt%. mixing a slurry A with a slurry B under the condition of a mixing temperature being >X°C and ≤100°C, and a residence time being ≤ 120 minutes to obtain a mixed slurry; treating the mixed slurry with spray drying to obtain catalyst precursor particles; and calcining the catalyst precursor particles to obtain the catalysts, wherein, X°C is the highest value among the solidifying points of slurry A, slurry B and the mixed slurry; slurry A is acidic and contains boron and chromium; slurry B contains copper, boron, alkali-metal elements, rare-earth elements, alumina sol, silica sol, carrier and optionally at least one of other metal elements selected from the group consisting of magnesium, calcium, barium, manganese, ruthenium and titanium, wherein, when the mixing temperature is between 50∼100°C, the residence time is ≤10 minutes, preferably 3∼10 minutes; when the mixing temperature is between 30∼50°C, the residence time is ≤30 minutes, preferably 10∼25 minutes; when the mixing temperature is >X°C and ≤30°C, the residence time is ≤120 minutes, preferably 20∼100 minutes, more preferably 40∼70 minutes; wherein the total content of iron and nickel in the mixed slurry after the mixing of slurry A and slurry B is ≤0.05wt%, preferably ≤0.02wt%, based on the total weight of the mixed slurry; and wherein the content of elemental sulphur in the mixed slurry after the mixing of slurry A and slurry B is ≤0.05wt%, preferably ≤0.02wt%.
A method for reducing a noise influence in a sensor measurement system, comprising: performing digital conversion measurements of a signal provided by a capacitive touch sensor wherein the signal represents a capacitance of the capacitive touch sensor , detecting that the signal provided by the capacitive sensor is affected by noise, wherein detecting that the signal provided by the capacitive sensor is affected by noise comprises performing noise scans on the signal, wherein a noise scan comprises subsequent sets of a plurality of capacitance measurements, each set of capacitance measurements providing a mean capacitive value and for each set calculating a difference between its mean capacitive value and a mean capacitive value of a preceding set of capacitive measurements, and summing the differences to form a summed mean difference, identifying whether noise affects the signal based on the summed mean difference, wherein a distinction between destructive and non-destructive noise is made based on a value of the summed mean difference; dynamically modifying sampling times between subsequent capacitance measurements based on the determination whether destructive noise affects the signal. performing digital conversion measurements of a signal provided by a capacitive touch sensor wherein the signal represents a capacitance of the capacitive touch sensor , detecting that the signal provided by the capacitive sensor is affected by noise, wherein detecting that the signal provided by the capacitive sensor is affected by noise comprises performing noise scans on the signal, wherein a noise scan comprises subsequent sets of a plurality of capacitance measurements, each set of capacitance measurements providing a mean capacitive value and for each set calculating a difference between its mean capacitive value and a mean capacitive value of a preceding set of capacitive measurements, and summing the differences to form a summed mean difference, identifying whether noise affects the signal based on the summed mean difference, wherein a distinction between destructive and non-destructive noise is made based on a value of the summed mean difference; dynamically modifying sampling times between subsequent capacitance measurements based on the determination whether destructive noise affects the signal.
Method for detecting cells in a liquid sample, having the following steps: a) filtering the liquid sample through a porous membrane by generation of a pressure difference, in which case a higher pressure is present upstream of the filter than downstream, the porous membrane being suitable for retaining cells to be detected, such that cells to be detected come to rest on at least part of the surface of the membrane and at least some of the sample liquid passes through the membrane, b) applying a first process liquid containing a first agent for marking the cells to be detected with a first marker, c) incubating the process liquid on the membrane for a predetermined time period, wherein the cells to be detected are marked, d) detecting the marked cells to be detected on the surface of the membrane, where during step c) a superatmospheric pressure is present on the side of the membrane which faces away from the side on which the cells to be detected have come to rest in step a), the superatmospheric pressure being selected such that flow of process liquid through the membrane is prevented. a) filtering the liquid sample through a porous membrane by generation of a pressure difference, in which case a higher pressure is present upstream of the filter than downstream, the porous membrane being suitable for retaining cells to be detected, such that cells to be detected come to rest on at least part of the surface of the membrane and at least some of the sample liquid passes through the membrane, b) applying a first process liquid containing a first agent for marking the cells to be detected with a first marker, c) incubating the process liquid on the membrane for a predetermined time period, wherein the cells to be detected are marked, d) detecting the marked cells to be detected on the surface of the membrane,
A hearing device for positioning at or partially or fully in an ear canal, the hearing device comprising: - a housing including a cavity extending through the housing ; - an optical transducer being mounted in the cavity , the optical transducer being mounted on a circuit board layer such that a spacing exists between a side of the optical transducer and a sidewall of the cavity ; - the circuit board layer extending underneath the housing and touching the housing such that the optical transducer is held within the cavity and - a protective substance forming a shield over the optical transducer and the cavity , the protective substance configured to affect a field of view of the optical transducer . characterized in that the protective substance includes one or more sealing glues, the one or more sealing glues filling the cavity and forming the shield as an outwardly curved shield. - a housing including a cavity extending through the housing ; - an optical transducer being mounted in the cavity , the optical transducer being mounted on a circuit board layer such that a spacing exists between a side of the optical transducer and a sidewall of the cavity ; - the circuit board layer extending underneath the housing and touching the housing such that the optical transducer is held within the cavity and - a protective substance forming a shield over the optical transducer and the cavity , the protective substance configured to affect a field of view of the optical transducer .