A targeting guide (5200; 4300) for use with a volar distal radius plate , comprising: - a body having an upper portion configured to be disposed on a head portion of the volar distal radius plate and a lower portion configured to couple the targeting guide (5200; 4300) to the volar distal radius plate ; - a plurality of cannulated openings corresponding to respective openings of the volar distal radius plate , wherein the cannulated openings are configured to facilitate drilling pilot holes and inserting fasteners at desired trajectories through the openings of the volar distal radius plate ; - a counterbored hole extending through the body ; - a retaining arm disposed adjacent the counterbored hole and extending from the lower portion of the body and into an opening in the volar distal radius plate , wherein the retaining arm includes a detent configured to receive and mate with a portion of the opening of the volar distal radius plate and a flange extending radially outward from a distal end of the retaining arm ; and - a cam screw disposed through the counterbored hole , wherein the cam screw includes a head and a shaft extending from the head , wherein the shaft includes a radially outwardly extending flange extending from a distal end of the shaft , characterized in that - the head includes a cam surface that extends radially from the head in a direction opposite to the radially outwardly extending flange , - wherein when the cam screw is moveable between an unlocked position, in which the targeting guide (5200; 4300) inserted into and removed from the volar distal radius plate , and a locked position, in which the targeting guide (5200; 4300) is locked onto the volar distal radius plate . - a body having an upper portion configured to be disposed on a head portion of the volar distal radius plate and a lower portion configured to couple the targeting guide (5200; 4300) to the volar distal radius plate ; - a plurality of cannulated openings corresponding to respective openings of the volar distal radius plate , wherein the cannulated openings are configured to facilitate drilling pilot holes and inserting fasteners at desired trajectories through the openings of the volar distal radius plate ; - a counterbored hole extending through the body ; - a retaining arm disposed adjacent the counterbored hole and extending from the lower portion of the body and into an opening in the volar distal radius plate , wherein the retaining arm includes a detent configured to receive and mate with a portion of the opening of the volar distal radius plate and a flange extending radially outward from a distal end of the retaining arm ; and - a cam screw disposed through the counterbored hole , wherein the cam screw includes a head and a shaft extending from the head , wherein the shaft includes a radially outwardly extending flange extending from a distal end of the shaft , characterized in that - the head includes a cam surface that extends radially from the head in a direction opposite to the radially outwardly extending flange , - wherein when the cam screw is moveable between an unlocked position, in which the targeting guide (5200; 4300) inserted into and removed from the volar distal radius plate , and a locked position, in which the targeting guide (5200; 4300) is locked onto the volar distal radius plate . <EOS>