A computer-implemented method for estimating a Reserve Strength Ratio, RSR, in a segment of a blood vessel or a lymphatic vessel, wherein RSR refers to a local measure that computes a propensity for rupture of a vessel, the method comprising: (a) providing a multiphase Digital Imaging and Communications in Medicine, DICOM, stack of computed tomography, CT, or magnetic resonance, MR, images of a blood vessel or a lymphatic vessel to software, wherein the stack of DICOM images is organized by phases corresponding to different times in the cardiac cycle; (b) providing an output from the software to a Model Segmentation procedure in which a first phase of the DICOM stack is segmented to create: a Geometric Model and mesh of the first phase and a map of Local Thickness Measure of the first phase; (c) uploading the mesh created for the first phase onto the DICOM image volume; (d) mapping each voxel position of the mesh for the first phase to all the subsequent meshes using an optical flow, OF, algorithm to obtain maps of displaced nodes; (e) creating deformed meshes at all phases from the maps of displaced nodes; (f) estimating local curvature at each node location for all the phases using a finite difference method; (g) evaluating a local deformation at each phase from the meshes corresponding to all the phases using an element approach; (h) calculating a local thickness at each node for all the phases using the local deformation calculation at each phase and the map of local thickness measure at the first phase by using an assumption of incompressibility for an aortic wall; and (i) calculating local principal stresses for each element from an extension of Laplace's equation applied to local principal directions of curvatures based on the local deformation at each phase, the local thickness at each node for all the phases and the local curvatures at each node for all the phases; whereby the RSR in a segment of a blood vessel or a lymphatic vessel is estimated based on the local principal stresses. (a) providing a multiphase Digital Imaging and Communications in Medicine, DICOM, stack of computed tomography, CT, or magnetic resonance, MR, images of a blood vessel or a lymphatic vessel to software, wherein the stack of DICOM images is organized by phases corresponding to different times in the cardiac cycle; (b) providing an output from the software to a Model Segmentation procedure in which a first phase of the DICOM stack is segmented to create: a Geometric Model and mesh of the first phase and a map of Local Thickness Measure of the first phase; (c) uploading the mesh created for the first phase onto the DICOM image volume; (d) mapping each voxel position of the mesh for the first phase to all the subsequent meshes using an optical flow, OF, algorithm to obtain maps of displaced nodes; (e) creating deformed meshes at all phases from the maps of displaced nodes; (f) estimating local curvature at each node location for all the phases using a finite difference method; (g) evaluating a local deformation at each phase from the meshes corresponding to all the phases using an element approach; (h) calculating a local thickness at each node for all the phases using the local deformation calculation at each phase and the map of local thickness measure at the first phase by using an assumption of incompressibility for an aortic wall; and (i) calculating local principal stresses for each element from an extension of Laplace's equation applied to local principal directions of curvatures based on the local deformation at each phase, the local thickness at each node for all the phases and the local curvatures at each node for all the phases; <EOS>