mhurhangee/patent-ind-claim-en huggingface dataset:
A method for improving the replication of a covalently closed circular plasmid comprising the following steps: a. providing a covalently closed circular plasmid comprising: i. a Pol I-dependent origin of replication, and ii. an insert comprising a structured DNA sequence selected from the group consisting of inverted repeat sequence, direct repeat sequence, homopolymeric repeat sequence, or eukaryotic origin of replication, wherein the structured DNA sequence is located at a distance of less than 1000 bp from the Pol I-dependent origin of replication in the direction of replication; and b. modifying the covalently closed circular plasmid of a. such that the Pol I-dependent origin of replication is replaced with an R6K gamma replication origin whereby the resultant R6K gamma replication origin covalently closed circular plasmid has improved replication selected from the group consisting of reduced production of replication intermediates and increased plasmid copy number relative to the covalently closed circular plasmid of a, wherein the R6K gamma replication origin does not require Pol I, and wherein the structured DNA sequence is located at a distance of less than 1000 bp from the R6K gamma replication origin in the direction of replication. a. providing a covalently closed circular plasmid comprising: i. a Pol I-dependent origin of replication, and ii. an insert comprising a structured DNA sequence selected from the group consisting of inverted repeat sequence, direct repeat sequence, homopolymeric repeat sequence, or eukaryotic origin of replication, wherein the structured DNA sequence is located at a distance of less than 1000 bp from the Pol I-dependent origin of replication in the direction of replication; and i. a Pol I-dependent origin of replication, and ii. an insert comprising a structured DNA sequence selected from the group consisting of inverted repeat sequence, direct repeat sequence, homopolymeric repeat sequence, or eukaryotic origin of replication, wherein the structured DNA sequence is located at a distance of less than 1000 bp from the Pol I-dependent origin of replication in the direction of replication; and b. modifying the covalently closed circular plasmid of a. such that the Pol I-dependent origin of replication is replaced with an R6K gamma replication origin whereby the resultant R6K gamma replication origin covalently closed circular plasmid has improved replication selected from the group consisting of reduced production of replication intermediates and increased plasmid copy number relative to the covalently closed circular plasmid of a, wherein the R6K gamma replication origin does not require Pol I, and wherein the structured DNA sequence is located at a distance of less than 1000 bp from the R6K gamma replication origin in the direction of replication.
A photochromic article, wherein the photochromic article comprises (I): (a) a photochromic substrate having a fade half-life-A (T 1/2 -A); (b) a photochromic layer having a fade half-life-B (T 1/2 -B) and being positioned between a first surface of the photochromic substrate and a source of actinic radiation, wherein the T 1/2 -A is greater than the T 1/2 -B by a factor of at least 1.5, the T 1/2 -A and the T 1/2 -B each being measured at 23°C; or wherein the photochromic article comprises (II): (a) a photochromic substrate, wherein the photochromic substrate comprises a first surface defined by a first photochromic layer having a fade half-life-A (T 1/2 -A); (b) a second photochromic layer having a fade half-life-B (T 1/2 -B) and being positioned between the first photochromic layer and a source of actinic radiation, wherein the T 1/2-A is greater than the T 1/2 -B by a factor of at least 1.5, the T 1/2 -A and the T 1/2 -B each being measured at 23°C. (a) a photochromic substrate having a fade half-life-A (T 1/2 -A); (b) a photochromic layer having a fade half-life-B (T 1/2 -B) and being positioned between a first surface of the photochromic substrate and a source of actinic radiation, wherein the T 1/2 -A is greater than the T 1/2 -B by a factor of at least 1.5, the T 1/2 -A and the T 1/2 -B each being measured at 23°C; (a) a photochromic substrate, wherein the photochromic substrate comprises a first surface defined by a first photochromic layer having a fade half-life-A (T 1/2 -A); (b) a second photochromic layer having a fade half-life-B (T 1/2 -B) and being positioned between the first photochromic layer and a source of actinic radiation,
A computer program for controlling a heat treatment of tissue, said computer program comprising instructions that are configured to cause the system of claim 12, when the program is executed on the control unit, to: obtain a measured temperature value from inside or outside a boundary of a predefined treatment lesion from the thermal sensor member or MRI; control, during a warm-up period being a predefined time range, the power output of the light source connected to the heating probe until said measured temperature reaches a target temperature, when said heating probe is interstitially inserted in said predefined treatment lesion; provide a warning and/or switching off said power output if said target temperature is reached outside of said predefined time range; and control, during a subsequent treatment period, said power output for maintaining said measured temperature at said target temperature during a time period. obtain a measured temperature value from inside or outside a boundary of a predefined treatment lesion from the thermal sensor member or MRI; control, during a warm-up period being a predefined time range, the power output of the light source connected to the heating probe until said measured temperature reaches a target temperature, when said heating probe is interstitially inserted in said predefined treatment lesion; provide a warning and/or switching off said power output if said target temperature is reached outside of said predefined time range; and control, during a subsequent treatment period, said power output for maintaining said measured temperature at said target temperature during a time period.
A nasal implant delivery tool comprising: an inner handle including a loading chamber configured to receive a nasal implant ; an outer handle configured to move axially relative to the inner handle between a plurality of discrete locking positions; locking structures configured to releasably lock the outer handle from moving relative to the inner handle at the discrete locking positions, including at a locking position preventing the outer handle from moving proximally relative to the inner handle; a retraction button configured to be depressed to allow release of the locked outer handle from the inner handle such that the outer handle can move proximally relative to the inner handle to allow loading of the implant; a needle extending distally from the inner handle, the needle having a central lumen and a distal opening; and a push rod configured to move the nasal implant from the loading chamber, through the central lumen, and out the distal opening of the needle, wherein the push rod is coupled to the outer handle such that the push rod moves axially relative to the inner handle when the outer handle is moved axially relative to the inner handle. an inner handle including a loading chamber configured to receive a nasal implant ; an outer handle configured to move axially relative to the inner handle between a plurality of discrete locking positions; locking structures configured to releasably lock the outer handle from moving relative to the inner handle at the discrete locking positions, including at a locking position preventing the outer handle from moving proximally relative to the inner handle; a retraction button configured to be depressed to allow release of the locked outer handle from the inner handle such that the outer handle can move proximally relative to the inner handle to allow loading of the implant; a needle extending distally from the inner handle, the needle having a central lumen and a distal opening; and a push rod configured to move the nasal implant from the loading chamber, through the central lumen, and out the distal opening of the needle, wherein the push rod is coupled to the outer handle such that the push rod moves axially relative to the inner handle when the outer handle is moved axially relative to the inner handle.
System for feeding a stack of labels , comprising a guide (24; 50), a carriage which is guided on the guide (26; 62), and has at least one urging element for the stack of labels, said carriage being urged on the guide against a removal position of the stack of labels, wherein the carriage (26; 62) can be moved along the guide by means of a drive mechanism (22; 42: 72) driven by a drive motor , wherein the drive mechanism (22; 42; 72) receives the urging force for the urging of the carriage (26; 62) into the removal position from the torque of the drive motor , characterised in that the drive motor is a static drive , with which the torque is generated by way of its drive axle, and the drive motor is configured such that, in a removal operation, the torque is consistently generated by the constantly driven drive motor , wherein it is not of relevance for the derivation of the torque whether the drive axle of the drive motor is rotating or not.
An image processing apparatus that generates ejection data for ink ejection by using a print head , the print head having a first nozzle array (L3) in which nozzles for ejecting a predetermined color of inks are arranged in a predetermined direction and a second nozzle array (L1, L2) in which nozzles for ejecting the predetermined color of inks are arranged in the predetermined direction, the first nozzle array and the second nozzle array being arranged in an intersection direction (A) intersecting the predetermined direction, the ink ejection being performed by that the print head ejects the predetermined color of inks to a print medium in order of the second nozzle array and the first nozzle array while relatively moving the print medium with respect to the print head in the intersection direction, the image processing apparatus comprising: a generating unit configured to generate the ejection data so that, in a case where image data is input in which the pixels corresponding to the first nozzles in the first nozzle array and the pixels corresponding to the second nozzles in the second nozzle array have the same value, the image processing apparatus being characterized in that a continuous number of pixels corresponding to the first nozzles becomes larger than the continuous number of pixels corresponding to the second nozzles, the continuous number being a number of continuous pixels where non-ink ejection are set in the intersection direction.
An anti-CD47 antibody that reduces the binding of CD47 to SIRPα and azacitidine for use in a method of treating a patient for a hematologic cancer.
A poly-phase switched reluctance motor assembly comprising: a stator assembly including a plurality of coils and a stator with a central bore, and a rotor assembly having a plurality of poles (130; 230), the rotor assembly being arranged within the central bore of the stator assembly and configured to rotate therein, wherein the stator includes a plurality of projecting stator teeth (120; 220) forming a plurality of stator slots (122; 222) therebetween, wherein the plurality of coils are in a distributed winding configuration, wherein the motor assembly includes at least three motor phases and wherein in use two motor phases are energized and at least one phase is non-energized during a conduction period, and wherein the motor assembly is adapted for control such that one of the two energized phases is provided with a positive current and the other of the two energized phases is provided with a negative current, characterized in that the total number of stator slots (122; 222) is a multiple of the number of phases and the number of rotor poles (130; 230) of the rotor assembly . a stator assembly including a plurality of coils and a stator with a central bore, and a rotor assembly having a plurality of poles (130; 230), the rotor assembly being arranged within the central bore of the stator assembly and configured to rotate therein, wherein the stator includes a plurality of projecting stator teeth (120; 220) forming a plurality of stator slots (122; 222) therebetween, wherein the plurality of coils are in a distributed winding configuration, wherein the motor assembly includes at least three motor phases and wherein in use two motor phases are energized and at least one phase is non-energized during a conduction period, and wherein the motor assembly is adapted for control such that one of the two energized phases is provided with a positive current and the other of the two energized phases is provided with a negative current, characterized in that the total number of stator slots (122; 222) is a multiple of the number of phases and the number of rotor poles (130; 230) of the rotor assembly .
Frequency converter having: - at least one bridge arm , wherein a shunt resistor is arranged in the at least one bridge arm , and - an evaluation device having an input connection , wherein the evaluation device is designed to evaluate a measurement signal (UM), which is present at the input connection and is dependent on a voltage dropped across the shunt resistor , in order to determine a measurement variable, characterized in that - the frequency converter has a voltage peak suppression device which is designed to short-circuit the input connection of the evaluation device if a voltage peak occurs at the shunt resistor , - wherein the voltage peak suppression device has: - at least one switching means which is looped in between the input connection of the evaluation device and is controlled by means of a control signal (UA), wherein the switching means short-circuits the input connection of the evaluation device on the basis of a state of the control signal (UA), and - a high-pass filter which generates the control signal (UA) on the basis of the voltage dropped across the shunt resistor . - at least one bridge arm , wherein a shunt resistor is arranged in the at least one bridge arm , and - an evaluation device having an input connection , wherein the evaluation device is designed to evaluate a measurement signal (UM), which is present at the input connection and is dependent on a voltage dropped across the shunt resistor , in order to determine a measurement variable, - the frequency converter has a voltage peak suppression device which is designed to short-circuit the input connection of the evaluation device if a voltage peak occurs at the shunt resistor , - wherein the voltage peak suppression device has: - at least one switching means which is looped in between the input connection of the evaluation device and is controlled by means of a control signal (UA), wherein the switching means short-circuits the input connection of the evaluation device on the basis of a state of the control signal (UA), and - a high-pass filter which generates the control signal (UA) on the basis of the voltage dropped across the shunt resistor . - at least one switching means which is looped in between the input connection of the evaluation device and is controlled by means of a control signal (UA), wherein the switching means short-circuits the input connection of the evaluation device on the basis of a state of the control signal (UA), and - a high-pass filter which generates the control signal (UA) on the basis of the voltage dropped across the shunt resistor .
An electrical box for flush mounting in an opening formed in a hollow partition panel , said electrical box comprising: • a side wall that defines a reception housing for receiving an accessory module and that is open at the front; • a shoulder that is adapted to bear against the front face of said panel and that is carried by a front portion of the side wall ; and • an annular portion that is situated between the front portion and a rear portion of the side wall , that is made out of the same material as said shoulder , and that is axially deformable; said electrical box being characterized in that : • catch means for catching against the rear of said panel are carried by the rear portion of the side wall , and comprise at least one flap that is adapted to pivot between a retracted position in which it does not form an obstacle to the electrical box being engaged in said opening and a deployed position in which it catches against the rear of said panel ; each flap being situated in an opening formed in the rear portion of the side wall , and being connected to the edge of the opening , over at least a portion of its periphery, via a gasket that is made out of a material that is more flexible than the material of the annular portion , the gasket interrupting the annular portion and presenting a bulge that is situated in the interruption. • a side wall that defines a reception housing for receiving an accessory module and that is open at the front; • a shoulder that is adapted to bear against the front face of said panel and that is carried by a front portion of the side wall ; and • an annular portion that is situated between the front portion and a rear portion of the side wall , that is made out of the same material as said shoulder , and that is axially deformable; • catch means for catching against the rear of said panel are carried by the rear portion of the side wall , and comprise at least one flap that is adapted to pivot between a retracted position in which it does not form an obstacle to the electrical box being engaged in said opening and a deployed position in which it catches against the rear of said panel ;
A lighting- and display device, which is designed to be operated in two different modes, specifically in a display mode and in a lighting mode, having - a display with a first light emission surface , and - a lighting element with a second light emission surface , wherein a surface is designated as a light emission surface, from which light can be actively emitted, wherein the first light emission surface is smaller than the second light emission surface and is thereby arranged in a center region with respect to the outer border of the second light emission surface and wherein both the display as well as the lighting element are designed to display individual image points on the respective light emission surface , wherein the display is designed to display more image points per surface unit than the lighting element, wherein the lighting- and display device is provided in the display mode at least primarily for displaying information by means of the display on the first light emission surface and is provided in the lighting mode at least primarily for lighting an environment of the lighting- and display device, wherein in the lighting mode light for the lighting is emitted not only via the light emission surface of the lighting element, but rather in addition also via the light emission surface of the display, wherein the display is designed to emit light in the same or in a similar color and/or in the same or in a similar brightness, as the lighting element, so that in the lighting mode a lighting is achieved, in which the light emission via the two light emission surfaces appears particularly homogeneous. - a display with a first light emission surface , and - a lighting element with a second light emission surface ,
A developer supply container demountably settable in a developer supply apparatus provided with an adaptation portion , said developer supply container comprising: a container body including an inner space that accommodates a developer and a discharge opening for permitting discharging of the developer; a feeding portion that feeds the developer in said container body toward said discharge opening with rotation of said container body ; an erroneous set prevention portion configured and positioned to permit or prevent, after said developer supply container is partially inserted into the developer supply apparatus along a rotational axis direction of said developer supply container , a further inserting operation for setting said developer supply container into the developer supply apparatus depending on the correspondence of said erroneous set prevention portion to a configuration of the adaptation portion ; and a leading portion configured to rotate with said erroneous set prevention portion with the inserting operation of said developer supply container to lead said erroneous set prevention portion toward the adaptation portion irrespective of a rotational position of said erroneous set prevention portion when said developer supply container is inserted, characterized in that said erroneous set prevention portion is provided rotatably around said container body . a container body including an inner space that accommodates a developer and a discharge opening for permitting discharging of the developer; a feeding portion that feeds the developer in said container body toward said discharge opening with rotation of said container body ; an erroneous set prevention portion configured and positioned to permit or prevent, after said developer supply container is partially inserted into the developer supply apparatus along a rotational axis direction of said developer supply container , a further inserting operation for setting said developer supply container into the developer supply apparatus depending on the correspondence of said erroneous set prevention portion to a configuration of the adaptation portion ; and a leading portion configured to rotate with said erroneous set prevention portion with the inserting operation of said developer supply container to lead said erroneous set prevention portion toward the adaptation portion irrespective of a rotational position of said erroneous set prevention portion when said developer supply container is inserted, characterized in that said erroneous set prevention portion is provided rotatably around said container body .
Arrangement comprising a magnetic stirrer having a heating plate and a control unit for controlling the magnetic stirrer and a lifting table having a platform on which the magnetic stirrer can be fitted, characterized in that the lifting table has an electric motor for lifting and lowering the platform , and in that a wireless or wired interface is provided between the magnetic stirrer and the lifting table , and the control unit is designed to control the electric motor , in particular the power supply of the electric motor , via the interface . the lifting table has an electric motor for lifting and lowering the platform , and in that a wireless or wired interface is provided between the magnetic stirrer and the lifting table , and the control unit is designed to control the electric motor , in particular the power supply of the electric motor , via the interface .