mhurhangee/patent-ind-claim-en huggingface dataset:
A method for removing large protein aggregate impurities from a biological product of interest, the method comprising steps of: pretreating a hydrophobic membrane filter with a surfactant solution having a mass concentration in the range of 0.01 to 10 %w/v surfactant so as to provide a pretreated membrane filter; and, filtering a fluid comprising a biological product through the pretreated membrane filter so as to obtain a filtrate comprising the biological product; wherein the membrane filter has a pore size sufficient to retain large protein aggregate impurities present in the fluid; and, wherein a higher yield of recovery of the biological product in the filtrate is achieved as compared to a non-pretreated control; wherein the biological product is or comprises a protein, a virus-like particle, a viral particle, a virion, or any combination thereof. pretreating a hydrophobic membrane filter with a surfactant solution having a mass concentration in the range of 0.01 to 10 %w/v surfactant so as to provide a pretreated membrane filter; and, filtering a fluid comprising a biological product through the pretreated membrane filter so as to obtain a filtrate comprising the biological product; wherein the membrane filter has a pore size sufficient to retain large protein aggregate impurities present in the fluid; and, wherein a higher yield of recovery of the biological product in the filtrate is achieved as compared to a non-pretreated control; wherein the biological product is or comprises a protein, a virus-like particle, a viral particle, a virion, or any combination thereof. wherein the membrane filter has a pore size sufficient to retain large protein aggregate impurities present in the fluid; and, wherein a higher yield of recovery of the biological product in the filtrate is achieved as compared to a non-pretreated control; wherein the biological product is or comprises a protein, a virus-like particle, a viral particle, a virion, or any combination thereof.
Electrical interconnection having a channel portion which comprises at least one channel layer made of a weak topological insulator material or any other three-dimensional topological insulator material which exhibits topologically protected one-dimensional electron channels and having a top surface characterized in that a plurality of grooves extend from a first terminal to a second terminal of the electrical interconnection , wherein the top surface and a bottom surface (12.2) of each groove are insulating, whereas each side surface (12.1) of each groove comprises a conducting zone with a pair of topologically protected one-dimensional electron channels .
Control device , in particular a transmission control device , which is designed to be fastened on an outer side or an inner side of a housing , in particular a transmission housing , so as to lie on the housing surface , wherein the control device comprises a printed circuit board and at least one plug (13; 14) which is arranged on the printed circuit board and is connected by its pins to corresponding conductor tracks of the printed circuit board, which plug is designed to project through an opening in the housing and, via conductor tracks arranged on the printed circuit board , to produce an electrical and/or signal connection between the outer side and the inner side of the housing , wherein an injection-moulded encapsulation surrounds at least the printed circuit board and the plug(s) (13; 14).
A set of essentially identical floor panels provided with a locking system comprising a separate flexible tongue integrated with an edge of a floor panel for connecting the edge vertically to an adjacent edge of a similar panel, wherein the flexible tongue has a length direction along the edge , wherein the flexible tongue comprises a reinforced, injection-moulded plastic material, wherein the floor panels are provided with first and second connectors , wherein the connectors are integrated with the floor panels and configured to connect adjacent edges, wherein the first connector comprises a locking strip with an upwardly directed locking element at an edge of a floor panel and a downwardly open locking groove at an adjacent edge of another floor panel for connecting the adjacent edges in a horizontal direction (D2) perpendicular to the adjacent edges, wherein the second connector comprises the flexible tongue at an edge of a floor panel, and a horizontally open tongue groove in an adjacent edge of another floor panel for connecting the adjacent edges in vertical direction (D1), wherein the connectors are configured to be locked with angling or a vertical motion, characterised in that at least a part of the flexible tongue is configured to be displaced essentially horizontally and essentially in one direction only from an initial position to a final outer locked position, wherein the flexible tongue is configured to be twisted along the joint during locking, and in that the locking part of the flexible tongue is arranged in an inner initial position in a displacement groove at an edge of a panel, and wherein the locking part is configured to be displaced essentially horizontally and essentially in one direction only from the initial position to a final outer position in the tongue groove of another adjacent panel.
A method of imparting hydrophilic properties to a sheet of polymeric material, characterized in the method comprises: - applying a 0.4-1.2% or 1.2-10% aqueous solution of a thermally-denatured water-soluble protein to a sheet of polymeric material, wherein the aqueous solution has a surface tension greater than 50 mN/m, and wherein the aqueous solution is substantially free of synthetic surfactants; and - drying the sheet such that at least a portion of the protein is retained on a surface of the sheet. - applying a 0.4-1.2% or 1.2-10% aqueous solution of a thermally-denatured water-soluble protein to a sheet of polymeric material, wherein the aqueous solution has a surface tension greater than 50 mN/m, and wherein the aqueous solution is substantially free of synthetic surfactants; and - drying the sheet such that at least a portion of the protein is retained on a surface of the sheet.
A computer implemented method for determining a shape of a path, comprising: receiving and collecting at a computer , trajectory data for a plurality of crowdsourced paths, wherein the trajectory data for each of the plurality of crowdsourced paths has associated therewith at least one uniquely identifiable ambient signal; at the computer , processing the collected trajectory data by: identifying a set of anchor points in the trajectory data for each of the plurality of crowdsourced paths, wherein an anchor point corresponds to a transition in a characteristic of trajectory data of an individual crowdsourced path; generating different potential matches between the sets of anchor points of each of the individual crowdsourced paths using geometrical mapping operations; evaluating the potential matches based on both geometric aspects of the trajectories that are being matched and similarity of the ambient signal of each of the crowdsourced paths, and selecting a best match among the evaluated potential matches; and generating a shape of a path by merging the trajectories of the crowdsourced paths based on the best match. receiving and collecting at a computer , trajectory data for a plurality of crowdsourced paths, wherein the trajectory data for each of the plurality of crowdsourced paths has associated therewith at least one uniquely identifiable ambient signal; at the computer , processing the collected trajectory data by: identifying a set of anchor points in the trajectory data for each of the plurality of crowdsourced paths, wherein an anchor point corresponds to a transition in a characteristic of trajectory data of an individual crowdsourced path; generating different potential matches between the sets of anchor points of each of the individual crowdsourced paths using geometrical mapping operations; evaluating the potential matches based on both geometric aspects of the trajectories that are being matched and similarity of the ambient signal of each of the crowdsourced paths, and selecting a best match among the evaluated potential matches; and generating a shape of a path by merging the trajectories of the crowdsourced paths based on the best match. identifying a set of anchor points in the trajectory data for each of the plurality of crowdsourced paths, wherein an anchor point corresponds to a transition in a characteristic of trajectory data of an individual crowdsourced path; generating different potential matches between the sets of anchor points of each of the individual crowdsourced paths using geometrical mapping operations; evaluating the potential matches based on both geometric aspects of the trajectories that are being matched and similarity of the ambient signal of each of the crowdsourced paths, and selecting a best match among the evaluated potential matches; and generating a shape of a path by merging the trajectories of the crowdsourced paths based on the best match.
Composition for use in inhibiting growth of a cancer tumor in a host and/or preventing cancer cells from metastasis in a host, wherein the composition is implanted into and around the tumor and/or the cancer cells such that the amount of host serum is reduced upon the implantation and the host serum reduction terminates myoblast proliferation and induces TNF-alpha release and myoblast fusion, wherein the composition comprises a quantum of genetically normal non-host myoblasts and host serum and is adapted to induce myoblast proliferation before being implanted and to induce myoblast fusion upon implantation in that a host serum level in the composition is above a content of 15 % by weight in the composition, and wherein the composition is implanted in at least one dosage containing 75 million to 250 million myoblasts per millilitre of the composition, and wherein the cancer belongs to the group consisting of melanoma cancer, prostate cancer, one or more breast cancers, gastrointestinal cancer, lung cancer, Ehrlich ascites cancer and liver cancer.
Fluid filter comprising a housing , a fluid inlet opening into a raw side of the fluid filter and a fluid outlet discharging from a pure side of the fluid filter , with a replaceable hollow-cylindrical filter insert separating the raw side from the pure side , and with a valve unit with a valve plate arranged concentrically in the housing and having the basic shape of an annular disc, with valve openings and a flexible, annular-disc-shaped valve membrane arranged on the valve plate , wherein on its end that faces the valve unit when in the mounted state the filter insert has an axially protruding pressure ring in the form of a circumferential annular collar, wherein the filter insert when installed in the housing presses the valve membrane axially against the valve plate with an end face of the pressure ring , whereby the area of the valve membrane that is pressed against the valve plate by the pressure ring forms a seal separating the raw side from the pure side of the fluid filter , wherein the valve unit is a check valve and wherein the filter insert when installed in the housing presses the valve membrane with the pressure ring against the valve plate in a radially inner membrane area (53.2), characterised in that a spring disc with radially outwardly oriented spring tabs is arranged on the side of the valve membrane facing away from the valve plate , and that the filter insert when installed in the housing pre-stresses and/or presses the spring disc with the pressure ring in a direction to the valve membrane .
A method of fabricating a ceramic matrix composite component comprising the steps of: forming a ceramic matrix composite component into a desired shape including a fibre reinforced layer, wherein the ceramic matrix composite includes a first side configured for exposure to a first temperature and a second side configured for exposure to a second temperature less than the first temperature; applying a layer of silicon material directly to a surface on the second side of the component, wherein the silicon material is bondable to the ceramic matrix composite, and wherein the layer of applied silicon material comprises an interface surface with a metal support member for mounting the ceramic matrix component; and machining the layer of silicon material to provide a desired dimension of the ceramic matrix composite component at the interface with the metal support member. forming a ceramic matrix composite component into a desired shape including a fibre reinforced layer, wherein the ceramic matrix composite includes a first side configured for exposure to a first temperature and a second side configured for exposure to a second temperature less than the first temperature; applying a layer of silicon material directly to a surface on the second side of the component, wherein the silicon material is bondable to the ceramic matrix composite, and wherein the layer of applied silicon material comprises an interface surface with a metal support member for mounting the ceramic matrix component; and machining the layer of silicon material to provide a desired dimension of the ceramic matrix composite component at the interface with the metal support member.
A functional derivative of N-acetyl cysteine (NAC) for use in a method for treatment of hereditary cystatin C amyloid angiopathy (HCCAA) in a human subject in need thereof, said method comprising administration of an effective amount of said functional derivative in a pharmaceutically acceptable carrier, said administration being effective to reduce amyloid-cystatin protein aggregates, thereby alleviating symptoms of HCCAA, wherein said NAC derivative is selected from NAC-amide, NAC-ethyl ester and zinc mercaptide N-acetyl cysteine carboxylate salt.
An electric heater for heating fluid streams, comprising a heating element and a control device in the form of a pulse width modulation (PWM) circuit for controlling a heat output generated by the heating element , wherein the heating element has an inductance (L_RHK) which changes depending on the temperature so that an edge steepness of current pulses of a current (I Heiz ) flowing through the heating element changes, characterized in that an overheating detection device is provided, which determines a peak value of a derivative of the current (I Heiz ) flowing through the heating element , compares this peak value with a previously defined threshold value and, if the threshold value is exceeded, detects overheating of the electric heater .
An isolated antibody, or an antigen-binding fragment thereof, that binds specifically to G protein-coupled receptor class C group 5 member D (GPRC5D), wherein the antibody or antigen binding fragment thereof comprises a variable heavy (VH) chain region of SEQ ID NO: 55 and a variable light (VL) chain region of SEQ ID NO: 58.
A tape curving attachment comprising: a tape curving section configured to curve component storage tape wound around a reel (Ra, Rb), the component storage tape being carrier tape with cavities in which components (P) are stored and top tape attached to an upper surface of the carrier tape , wherein the tape curving section is configured to curve the component storage tape such that the radius of curvature (r3) of the top tape side of the component storage tape is smaller or larger than the radius of curvature (r2) of the carrier tape side of the component storage tape , the tape curving attachment being configured to be attached to a feeder that pitch feeds the component storage tape from the reel (Ra, Rb), wherein the tape curving attachment further comprises a frame , the frame being provided with a catch on a rear end of the frame , the catch being configured to catch on a reel holding section of the feeder , and the tape curving section includes a first roller , a second roller and a third roller , wherein the first roller is provided at the reel holding section and the second roller and the third roller are supported on the frame , or wherein the first roller , the second roller and the third roller are supported on the frame , and the component storage tape being fed on an upper side, a lower side, and an upper side of the first roller , the second roller and the third roller respectively. a tape curving section configured to curve component storage tape wound around a reel (Ra, Rb), the component storage tape being carrier tape with cavities in which components (P) are stored and top tape attached to an upper surface of the carrier tape , wherein the tape curving section is configured to curve the component storage tape such that the radius of curvature (r3) of the top tape side of the component storage tape is smaller or larger than the radius of curvature (r2) of the carrier tape side of the component storage tape , the tape curving attachment being configured to be attached to a feeder that pitch feeds the component storage tape from the reel (Ra, Rb), wherein the tape curving attachment further comprises a frame , the frame being provided with a catch on a rear end of the frame , the catch being configured to catch on a reel holding section of the feeder , and the tape curving section includes a first roller , a second roller and a third roller , wherein the first roller is provided at the reel holding section and the second roller and the third roller are supported on the frame , or wherein the first roller , the second roller and the third roller are supported on the frame , wherein the first roller is provided at the reel holding section and the second roller and the third roller are supported on the frame , or wherein the first roller , the second roller and the third roller are supported on the frame , and the component storage tape being fed on an upper side, a lower side, and an upper side of the first roller , the second roller and the third roller respectively.
An organic light emitting device (OLED) comprising: an anode ; a cathode ; and an emissive region disposed between the anode and the cathode, the emissive region comprising a sensitizer and an acceptor, wherein the sensitizer has a lowest excitation energy state E T 1 , and is capable of harvesting triplet excitons; wherein the acceptor is capable of receiving energy from the sensitizer and functioning as a fluorescent emitter at room temperature; characterised in that the acceptor has a first moiety and a second moiety, the first moiety having a lowest singlet excitation energy state E S 1 A and a lowest triplet excitation energy state E T 1 A , and the second moiety having a lowest singlet excitation energy state E S 1 B and a lowest triplet excitation energy state E T 1 B ; and wherein E S 1 A < E S 1 B , E T 1 A > E T 1 B , and E T 1 > E S 1 A , wherein the lowest singlet excitation energy states and the lowest triplet excitation energy states are obtained according to the method disclosed in the description. an anode ; a cathode ; and an emissive region disposed between the anode and the cathode, the emissive region comprising a sensitizer and an acceptor, wherein the sensitizer has a lowest excitation energy state E T 1 , and is capable of harvesting triplet excitons; wherein the acceptor is capable of receiving energy from the sensitizer and functioning as a fluorescent emitter at room temperature; characterised in that the acceptor has a first moiety and a second moiety, the first moiety having a lowest singlet excitation energy state E S 1 A and a lowest triplet excitation energy state E T 1 A , and the second moiety having a lowest singlet excitation energy state E S 1 B and a lowest triplet excitation energy state E T 1 B ; and wherein E S 1 A < E S 1 B , E T 1 A > E T 1 B , and E T 1 > E S 1 A , wherein the lowest singlet excitation energy states and the lowest triplet excitation energy states are obtained according to the method disclosed in the description.
A method of controlling an axle assembly that includes a housing assembly , a drive pinion that is selectively connectable to a torque source , and a differential assembly that is received in the housing assembly and has a ring gear that meshes with the drive pinion , wherein the differential assembly is selectively connectable to a wheel hub that supports a wheel , the method comprising: operatively connecting the wheel hub to the differential assembly when the ring gear does not receive torque from the torque source such that torque from the wheel hub rotates the ring gear and the ring gear splashes lubricant in the housing assembly .
A method for updating a private key of a host entity, which belongs to a group of host entities , the private key being based on parameters negotiated between the host entity and a key issuer , the host entity further having a group public key, which is valid for the group of host entities and which is generated by the key issuer and associated with the private key, the method being performed by the host entity , the method comprising: obtaining (S108) a need to acquire a new private key; and in response thereto performing (S110) a private key update procedure with the key issuer using the group public key and the current private key, wherein parameters for the new private key are negotiated with the key issuer ; and generating (S112) the new private key using the negotiated parameters. obtaining (S108) a need to acquire a new private key; and in response thereto performing (S110) a private key update procedure with the key issuer using the group public key and the current private key, wherein parameters for the new private key are negotiated with the key issuer ; and generating (S112) the new private key using the negotiated parameters.
Device for coating containers by means of a coating process, with a main supporting frame, wherein the following units are present inside the main supporting frame: - a treatment station for coating the containers , - a transfer device , which moves the containers between at least one conveying device and treatment station, wherein the units also comprise the at least one conveying device or can be connected to the at least one conveying device , wherein the transfer device has a gripper unit , which is mounted pivotably along a pivot axis aligned parallel to the conveying device on a gripper frame , which is arranged fixed in place in relation to the main supporting frame during the operation of the device and/or is part of the main supporting frame, wherein the gripper unit can be moved between a first position, in which it can grip the containers in the region of the conveying device , and a second position, in which it can insert the containers into the treatment station and fetch them from it. - a treatment station for coating the containers , - a transfer device , which moves the containers between at least one conveying device and treatment station,
A composition for a keratin substance, such as skin, comprising: (a) at least one plate type filler having a particle size of 5 μm or less, and preferably 3 μm or less; (b) at least one pearlescent pigment having a particle size of 15 μm or less, preferably 12 μm or less, and more preferably 10 μm or less; and (c) at least one hollow or porous particle, wherein the (a) plate type filler consists essentially of boron nitride, and has a refractive index of 2.0 or less, preferably 1.9 or less, and more preferably 1.8 or less, and the (b) pearlescent pigment comprises mica and metal oxide, and has a colored reflection. (a) at least one plate type filler having a particle size of 5 μm or less, and preferably 3 μm or less; (b) at least one pearlescent pigment having a particle size of 15 μm or less, preferably 12 μm or less, and more preferably 10 μm or less; and (c) at least one hollow or porous particle, the (a) plate type filler consists essentially of boron nitride, and has a refractive index of 2.0 or less, preferably 1.9 or less, and more preferably 1.8 or less, and the (b) pearlescent pigment comprises mica and metal oxide, and has a colored reflection.