A system , comprising: a computer readable storage medium with computer executable instructions , including: a biophysical simulator component configured to determine a fractional flow reserve value via simulation and a traffic light engine configured to track a user-interaction with the biophysical simulator component at one or more points of the simulation to determine the fractional flow reserve value; a processor configured to execute the biophysical simulator component to determine the fractional flow reserve value and configured to execute the traffic light engine to track the user-interaction with respect to determining the fractional flow reserve value and provide a warning in response to determining there is a potential incorrect interaction, wherein the biophysical simulator component includes a coronary tree modeling component , which receives volumetric image data and generates a 3-D anatomical model of coronary arteries therefrom, and wherein the biophysical simulator component further includes a personalized feature extraction component , which receives the 3-D anatomical model of coronary arteries and extracts personalized features therefrom, wherein the user-interaction further includes at least one of changing a centerline of a coronary vessel and changing a contour line of a coronary vessel, and the traffic light engine extracts at least one of a set of features about the changed centerline or a set of features about the changed contour line, the set of features describing the changed centerline or the changed contour line, and determines a quality score based on the set of extracted features, wherein the warning is based on the quality score; and a display configured to display the warning requesting verification to proceed with the simulation from the point, wherein the simulation is resumed only in response to the processor receiving the requested verification. a computer readable storage medium with computer executable instructions , including: a biophysical simulator component configured to determine a fractional flow reserve value via simulation and a traffic light engine configured to track a user-interaction with the biophysical simulator component at one or more points of the simulation to determine the fractional flow reserve value; a processor configured to execute the biophysical simulator component to determine the fractional flow reserve value and configured to execute the traffic light engine to track the user-interaction with respect to determining the fractional flow reserve value and provide a warning in response to determining there is a potential incorrect interaction, wherein the biophysical simulator component includes a coronary tree modeling component , which receives volumetric image data and generates a 3-D anatomical model of coronary arteries therefrom, and wherein the biophysical simulator component further includes a personalized feature extraction component , which receives the 3-D anatomical model of coronary arteries and extracts personalized features therefrom, wherein the user-interaction further includes at least one of changing a centerline of a coronary vessel and changing a contour line of a coronary vessel, and the traffic light engine extracts at least one of a set of features about the changed centerline or a set of features about the changed contour line, the set of features describing the changed centerline or the changed contour line, and determines a quality score based on the set of extracted features, wherein the warning is based on the quality score; and a display configured to display the warning requesting verification to proceed with the simulation from the point, wherein the simulation is resumed only in response to the processor receiving the requested verification. <EOS>