A compound of formula I: wherein: n is 1 or 2; p is 0 or 1; R 1a , R 1b , R 1c and R 1d are independently selected from the group consisting of H, halo, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 fluoroalkyl, C 3-4 cycloalkyl, NH-C 1-4 alkyl and cyano; R 2a and R 2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 2c and R 2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 2e is H or Me; R 3a and R 3b are independently selected from H and Me; R 4 is either H or Me; R 5 is either H or Me; R 6a and R 6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C 5-12 heteroaryl; wherein the optional substituents on A are independently selected from the group consisting of: C 1-4 alkyl, C 1-4 fluoroalkyl, C 3-6 cycloalkyl, C 5-6 heteroaryl, C 5-6 heteroaryl methyl, C 4-6 heterocyclyl, C 4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C 1-4 alkyl ester, C 1-4 alkyl ester methyl, C 1-4 alkyl carbamoyl, C 1-4 alkyl carbamoyl methyl, C 1-4 alkylacyl, C 1-4 alkylacyl methyl, phenylcarbonyl, carboxy, carboxymethyl, ether, amino, aminomethyl, sulfonamido, sulfonamino, sulfone, sulfoxide, nitrile and nitrilemethyl and when A is phenyl, the optional substituent may also be a fused C 5-6 N 1 -containing heterocyclic ring; wherein when R 2e is H, at least one of R 1a , R 1b , R 1c and R 1d is selected from C 1-4 alkoxy, C 2-4 alkyl, C 1-4 fluoroalkyl, C 3-4 cycloalkyl, NH-C 1-4 alkyl and cyano. n is 1 or 2; p is 0 or 1; R 1a , R 1b , R 1c and R 1d are independently selected from the group consisting of H, halo, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 fluoroalkyl, C 3-4 cycloalkyl, NH-C 1-4 alkyl and cyano; R 2a and R 2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 2c and R 2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; (i) F; (ii) H; (iii) Me; and (iv) CH 2 OH; R 2e is H or Me; R 3a and R 3b are independently selected from H and Me; R 4 is either H or Me; R 5 is either H or Me; R 6a and R 6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C 5-12 heteroaryl; (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C 5-12 heteroaryl; wherein the optional substituents on A are independently selected from the group consisting of: C 1-4 alkyl, C 1-4 fluoroalkyl, C 3-6 cycloalkyl, C 5-6 heteroaryl, C 5-6 heteroaryl methyl, C 4-6 heterocyclyl, C 4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C 1-4 alkyl ester, C 1-4 alkyl ester methyl, C 1-4 alkyl carbamoyl, C 1-4 alkyl carbamoyl methyl, C 1-4 alkylacyl, C 1-4 alkylacyl methyl, phenylcarbonyl, carboxy, carboxymethyl, ether, amino, aminomethyl, sulfonamido, sulfonamino, sulfone, sulfoxide, nitrile and nitrilemethyl and when A is phenyl, the optional substituent may also be a fused C 5-6 N 1 -containing heterocyclic ring; wherein when R 2e is H, at least one of R 1a , R 1b , R 1c and R 1d is selected from C 1-4 alkoxy, C 2-4 alkyl, C 1-4 fluoroalkyl, C 3-4 cycloalkyl, NH-C 1-4 alkyl and cyano. <EOS>