Device for closing or ligating a target tissue at the inner wall of a hollow organ, such as the digestive tract or other body lumens and hollow organs, characterized in that it comprises: • a proximal part provided with a first protrusion and a first slot , • a first arm and a second arm fixed to each other at said proximal part , said first arm being provided with a first distal end and a second slot , said second arm being provided with a second distal end , • a flexible tightening thread connecting said first and second arms at their respective first and second distal ends , said flexible tightening thread forming a first loop passing from an outer side of the first arm into the second slot , • a flexible control thread comprising a second loop , wherein said device is designed to move: • from an open configuration, wherein: • said first and second distal ends are spaced apart from each other, • the control thread extends through said first slot toward the first loop , passes through it, and then returns to said proximal part to be fixed to said first protrusion with the second loop , • to a closed configuration, after a pulling force has been exerted on the control thread , wherein: • the control thread pulls along said first loop up to said first protrusion , so that the latter retains said first loop , • the control thread releases from said first protrusion , • said first and second distal ends are drawn toward each other by the tightening thread , for closing or ligating the target tissue. • a proximal part provided with a first protrusion and a first slot , • a first arm and a second arm fixed to each other at said proximal part , said first arm being provided with a first distal end and a second slot , said second arm being provided with a second distal end , • a flexible tightening thread connecting said first and second arms at their respective first and second distal ends , said flexible tightening thread forming a first loop passing from an outer side of the first arm into the second slot , • a flexible control thread comprising a second loop , wherein said device is designed to move: • from an open configuration, wherein: • said first and second distal ends are spaced apart from each other, • the control thread extends through said first slot toward the first loop , passes through it, and then returns to said proximal part to be fixed to said first protrusion with the second loop , • said first and second distal ends are spaced apart from each other, • the control thread extends through said first slot toward the first loop , passes through it, and then returns to said proximal part to be fixed to said first protrusion with the second loop , • to a closed configuration, after a pulling force has been exerted on the control thread , wherein: • the control thread pulls along said first loop up to said first protrusion , so that the latter retains said first loop , • the control thread releases from said first protrusion , • said first and second distal ends are drawn toward each other by the tightening thread , for closing or ligating the target tissue. • the control thread pulls along said first loop up to said first protrusion , so that the latter retains said first loop , • the control thread releases from said first protrusion , • said first and second distal ends are drawn toward each other by the tightening thread , for closing or ligating the target tissue. <EOS>