mhurhangee/patent-ind-claim-en huggingface dataset:
A method for inhibiting proliferation and/or inducing apoptosis in a leukemia cell in vitro, comprising contacting the leukemia cell with an inhibitor of interaction between MLL1 and menin, wherein the leukemia cell exhibits an NPM1 mutation, and wherein the leukemia cell does not exhibit a genetic mutation, alteration, and/or abnormality that is an MLL-translocation (MLL-t), an MLL-rearrangement (MLL-r), or an MLL-partial tandem duplication (MLL-PTD).
A drive belt for a continuously variable transmission with at least one annular carrier and with a number of transverse segments (40; 40a, 40b) arranged slidably on the carrier in a row along the circumference thereof, which transverse segments (40; 40a, 40b) are all provided with two main body surfaces, where between the transverse segment (40; 40a, 40b) extends in thickness direction, and with a circumference surface located between and connecting the main body surfaces, whereof parts, named contact surfaces (43; 43a, 43b), are mutually oriented at an acute angle (φ) and are destined to arrive in friction contact with pulleys of the transmission, and which transverse segments are all provided with a widthwise extending, convexly curved transition surface part of one of the main body surfaces thereof, named rocking edge , that is located between a top part of the transverse segment and a tapered bottom part thereof and that serves as a fulcrum for the mutual rotation of adjoining transverse segments (40; 40a, 40b) in the said row of transverse segments (40; 40a, 40b) of the drive belt , wherein two types of the transverse segments (40; 40a, 40b) are included in the drive belt , characterized in that the contact surfaces (43; 43a, 43b) are provided with a height dimension (H1; H2) in the radial direction of the drive belt that is different between the said two transverse segment types , which height dimension (H1) of the contact surfaces of the transverse segments (40; 40a, 40b) of a first type is larger than a mathematical product of a largest width dimension (W1) between these contact surfaces and half the sine value of the angle (φ) between these contact surfaces and which height dimension (H2) of the contact surfaces of the transverse segments (40; 40a, 40b) of a second type is smaller than a mathematical product of a largest width dimension (W2) between these contact surfaces and half the sine value of the angle (φ) between these contact surfaces .
A fire suppression agent composition comprising 40 to 70 wt.% of CF 3 I and greater than or equal to 30 wt% of an additional fire suppression agent which is HFC-23, wherein the fire suppression agent composition passes the FAA aerosol can test, wherein in the FAA aerosol can test, a heated container at about 16 bar releases its contents (270 grams ethanol, 90 grams propane, and 90 grams water) as a two-phase impulsive spray via a fast-acting valve, and a continuous direct current arc across electrodes (with a 6.4 mm gap shielded from the high-velocity spray) located about 1 meter downstream of the valve ignites the mixture in a chamber atmosphere of premixed ambient air, water vapor and suppressant.
A method for recovering lost clusters on a mounted volume defined according to a file system comprising a directory table and one or more logical allocation structures, wherein the directory table comprises entries describing a tree structure which indicates a relationship between files and directories and identifies a first cluster of a file system data object, wherein the logical allocation structures comprise a file allocation table, wherein the file allocation table describes a sequence of clusters that are allocated to a file system data object, , the method comprising the following steps executed by a file system driver : receiving the mounted volume; reading the entries included within the directory table; generating an allocation bitmap based on the read entries; prior to reading all of the entries included within the directory table, determining any and all cluster allocation changes that occurs in the mounted volume while the entries are being read; modifying the allocation bitmap based on the cluster allocation changes; comparing the modified allocation bitmap to the logical allocation structures; and determining, if the modified allocation bitmap indicates that one or more clusters of the mounted volume are free and the logical allocation structures indicate that the one or more clusters of the mounted volume are in use, that the one or more clusters are lost clusters, and recovering the lost clusters. receiving the mounted volume; reading the entries included within the directory table; generating an allocation bitmap based on the read entries; prior to reading all of the entries included within the directory table, determining any and all cluster allocation changes that occurs in the mounted volume while the entries are being read; modifying the allocation bitmap based on the cluster allocation changes; comparing the modified allocation bitmap to the logical allocation structures; and determining, if the modified allocation bitmap indicates that one or more clusters of the mounted volume are free and the logical allocation structures indicate that the one or more clusters of the mounted volume are in use, that the one or more clusters are lost clusters, and recovering the lost clusters.
A method of operating an inductive power transfer system for transferring power, wherein the inductive power transfer system comprises a primary winding structure for generating an alternating electromagnetic field and a secondary winding structure for receiving the alternating electromagnetic field and generating an alternating current output voltage, wherein the alternating current output voltage is rectified and supplied to at least one energy storage element , wherein the rectified output voltage (U C ) is adjusted by varying a gap size of a gap between the primary winding structure and the secondary winding structure, wherein the gap size is adjusted to prepare an energy transfer process and/or to initiate an energy transfer process and/or to control an energy transfer process depending on charging characteristics of the at least one energy storage element , characterized in that the gap size is adjusted such that a desired rectified output voltage (U C,des ) is provided, wherein the gap size is held constant as long as a desired rectified output voltage (U C,des ) is providable by adjusting the input voltage (U WPC ) of the wayside power converter , wherein the input voltage (U WPC ) of the wayside power converter is adjustable between given voltage limits wherein the gap size is adjusted to prepare an energy transfer process and/or to initiate an energy transfer process and/or to control an energy transfer process depending on charging characteristics of the at least one energy storage element , characterized in that the gap size is adjusted such that a desired rectified output voltage (U C,des ) is provided, wherein the gap size is held constant as long as a desired rectified output voltage (U C,des ) is providable by adjusting the input voltage (U WPC ) of the wayside power converter , wherein the input voltage (U WPC ) of the wayside power converter is adjustable between given voltage limits
A compound having the Formula I or II: or or a pharma eaclceutically acceptable salt thereof, wherein: X is Ba is independently selected from adenine (A), guanine (G), cytosine (C), and thymine (T); q is O or S; s is 9 ; an integer from 1 to 10; y is an integer from 1 to 10; z is an integer from 1 to 10; each X 1 is independently selected from Leu, Val, and Ala; each X 2 is independently selected from Thr and Ser; each X 3 is Phe; each X 4 is independently selected from Aib, Ala, and Glu; each X 5 is independently selected from Glu, Asp, and His; each X 6 is independently selected from Tyr, Phe, and Ser; each X 7 is Trp; each X 8 is independently selected from Aib, Ala, and Val; each X 9 is independently selected from Gln and Asn; each X 10 is Leu; each X 11 is independently selected from Aib, Thr, and Ala; each X 12 is independently selected from Ser and Thr; each X 13 is independently selected from Ala and Gly; and each X 14 is independently selected from Ala and Gly. X is Ba is independently selected from adenine (A), guanine (G), cytosine (C), and thymine (T); q is O or S; s is 9 ; an integer from 1 to 10; y is an integer from 1 to 10; z is an integer from 1 to 10; each X 1 is independently selected from Leu, Val, and Ala; each X 2 is independently selected from Thr and Ser; each X 3 is Phe; each X 4 is independently selected from Aib, Ala, and Glu; each X 5 is independently selected from Glu, Asp, and His; each X 6 is independently selected from Tyr, Phe, and Ser; each X 7 is Trp; each X 8 is independently selected from Aib, Ala, and Val; each X 9 is independently selected from Gln and Asn; each X 10 is Leu; each X 11 is independently selected from Aib, Thr, and Ala; each X 12 is independently selected from Ser and Thr; each X 13 is independently selected from Ala and Gly; and each X 14 is independently selected from Ala and Gly.
A replacement heart valve configured for implantation within an annulus of a native heart valve, comprising: an expandable anchor member including an upstream portion forming an upstream chamber , a downstream portion forming a downstream chamber , and a tubular middle portion disposed between the upstream portion and the downstream portion; wherein the tubular middle portion forms a longitudinally-oriented lumen extending between the upstream portion and the downstream portion, wherein the downstream chamber extends radially outward from the tubular middle portion ; and a disc-shaped diaphragm disposed within the downstream chamber of the anchor member , wherein the tubular middle portion is positionable within the annulus of the native heart valve with the upstream chamber disposed upstream of the annulus and the downstream chamber disposed downstream of the annulus characterized in that the disc-shaped diaphragm is free to move axially within the downstream chamber of the anchor member in response to fluid flow through the tubular middle portion , wherein the disc-shaped diaphragm moves away from the tubular middle portion , thereby permitting fluid flow through the tubular middle portion , in response to a positive fluid pressure differential between the tubular middle portion and the downstream portion, wherein the disc-shaped diaphragm moves against the tubular middle portion , thereby preventing fluid flow through the tubular middle portion , in response to a negative fluid pressure differential between the tubular middle portion and the downstream portion. an expandable anchor member including an upstream portion forming an upstream chamber , a downstream portion forming a downstream chamber , and a tubular middle portion disposed between the upstream portion and the downstream portion; wherein the tubular middle portion forms a longitudinally-oriented lumen extending between the upstream portion and the downstream portion, wherein the downstream chamber extends radially outward from the tubular middle portion ; and a disc-shaped diaphragm disposed within the downstream chamber of the anchor member , wherein the tubular middle portion is positionable within the annulus of the native heart valve with the upstream chamber disposed upstream of the annulus and the downstream chamber disposed downstream of the annulus characterized in that the disc-shaped diaphragm is free to move axially within the downstream chamber of the anchor member in response to fluid flow through the tubular middle portion , wherein the disc-shaped diaphragm moves away from the tubular middle portion , thereby permitting fluid flow through the tubular middle portion , in response to a positive fluid pressure differential between the tubular middle portion and the downstream portion, wherein the disc-shaped diaphragm moves against the tubular middle portion , thereby preventing fluid flow through the tubular middle portion , in response to a negative fluid pressure differential between the tubular middle portion and the downstream portion.
An optical backplane system , wherein the optical backplane system comprises: a first upper-level optical interconnection module , wherein the first upper-level optical interconnection module comprises M1 first interfaces and N1 second interfaces, and there are connection relationships between the M1 first interfaces and the N1 second interfaces; and characterized in that the optical backplane system further comprises a first lower-level optical interconnection module , and a second lower-level optical interconnection module , wherein the first lower-level optical interconnection module comprises L1 third interfaces and K1 fourth interfaces, and there are connection relationships between the L1 third interfaces and the K1 fourth interfaces; the second lower-level optical interconnection module comprises L2 third interfaces and K2 fourth interfaces, and there are connection relationships between the L2 third interfaces and the K2 fourth interfaces; the first upper-level optical interconnection module is connected to one of the L1 third interfaces of the first lower-level optical interconnection module by using one of the N1 second interfaces; the first upper-level optical interconnection module is connected to one of the L2 third interfaces of the second lower-level optical interconnection module by using another one of the N1 second interfaces; and all the M1 first interfaces, the K1 fourth interfaces, and the K2 fourth interfaces are configured to connect to processing modules, wherein all M1, N1, K1, K2, L1, and L2 are integers greater than 1. a first upper-level optical interconnection module , wherein the first upper-level optical interconnection module comprises M1 first interfaces and N1 second interfaces, and there are connection relationships between the M1 first interfaces and the N1 second interfaces; and characterized in that the optical backplane system further comprises a first lower-level optical interconnection module , and a second lower-level optical interconnection module , wherein the first lower-level optical interconnection module comprises L1 third interfaces and K1 fourth interfaces, and there are connection relationships between the L1 third interfaces and the K1 fourth interfaces; the second lower-level optical interconnection module comprises L2 third interfaces and K2 fourth interfaces, and there are connection relationships between the L2 third interfaces and the K2 fourth interfaces; the first upper-level optical interconnection module is connected to one of the L1 third interfaces of the first lower-level optical interconnection module by using one of the N1 second interfaces; the first upper-level optical interconnection module is connected to one of the L2 third interfaces of the second lower-level optical interconnection module by using another one of the N1 second interfaces; and all the M1 first interfaces, the K1 fourth interfaces, and the K2 fourth interfaces are configured to connect to processing modules, wherein all M1, N1, K1, K2, L1, and L2 are integers greater than 1.
An isolated, therapeutic human antibody or antigen-binding portion thereof, comprising a heavy chain variable region (V H ) according to SEQ ID NO: 12 and a light chain variable region (V L ) according to SEQ ID NO: 43, and wherein said antibody or antigen-binding portion thereof specifically binds to homodimeric IL-17A and heterodimeric IL-17AF, but does not specifically bind to homodimeric IL-17F.
A self-retracting lifeline assembly comprising: a housing ; a housing cover piece a shaft comprising first and second ends, the shaft being fixed at the first end to the housing against rotation relative to the housing about a central axis of the shaft ; a drum mounted for rotation on the shaft and including a compartment within the drum , wherein the drum is a two-piece construction with a first piece defining the compartment and a second piece forming a cover for closing the compartment ; a lifeline wound on the drum for selective deployment and retraction from and to the housing ; a spring mechanism connected between the first end of the shaft and the drum and configured to apply a rotational retracting force to the drum ; a brake module carried on the shaft and mounted within the compartment of the drum ; a pawl mechanism mounted on the drum for rotation therewith, the pawl mechanism mounted within the compartment and configured to selectively engage the brake module in response to a pre-determined rotational speed of the drum relative to the shaft ; and wherein the housing cover piece and the second piece of the drum are removable to allow for removal of the brake module as a self-contained sub-assembly from the self-retracting lifeline assembly at the second end of the shaft . a housing ; a housing cover piece a shaft comprising first and second ends, the shaft being fixed at the first end to the housing against rotation relative to the housing about a central axis of the shaft ; a drum mounted for rotation on the shaft and including a compartment within the drum , wherein the drum is a two-piece construction with a first piece defining the compartment and a second piece forming a cover for closing the compartment ; a lifeline wound on the drum for selective deployment and retraction from and to the housing ; a spring mechanism connected between the first end of the shaft and the drum and configured to apply a rotational retracting force to the drum ; a brake module carried on the shaft and mounted within the compartment of the drum ; a pawl mechanism mounted on the drum for rotation therewith, the pawl mechanism mounted within the compartment and configured to selectively engage the brake module in response to a pre-determined rotational speed of the drum relative to the shaft ; and wherein the housing cover piece and the second piece of the drum are removable to allow for removal of the brake module as a self-contained sub-assembly from the self-retracting lifeline assembly at the second end of the shaft .
A glazing comprising: a first glass substrate ; a second glass substrate ; and a viewing area of an information acquisition system , wherein the viewing area is formed to provide an optical power pattern in which the optical power varies across the viewing area, based on distance from which information is to be collected, and wherein the optical power is transmitted optical power, wherein the optical power pattern is determined by a difference in refractive index of at least one of the first and second glass substrates . a first glass substrate ; a second glass substrate ; and a viewing area of an information acquisition system , wherein the viewing area is formed to provide an optical power pattern in which the optical power varies across the viewing area, based on distance from which information is to be collected, and wherein the optical power is transmitted optical power, wherein the optical power pattern is determined by a difference in refractive index of at least one of the first and second glass substrates .
A method for tracking a status of a call in a wireless communication system including an eNodeB and a Mobile Management Entity, MME, , the method comprising steps of: receiving, by a processor , a plurality of data packets from the wireless communication system ; analyzing, by the processor , S1 - Application Protocol, S1-AP, signaling messages exchanged between the eNodeB and the MME over a first interface for a specified time period and analyzing bearer related events and one or more error codes associated with the bearer related events, the S1-AP signaling messages associated with live calls being made or attempted in the wireless communication system to identify one or more dropped calls; tracking S1-AP session information corresponding to the analyzed S1-AP messages, wherein each tracked S1-AP session maintains one or more E-Radio Access Bearer, E-RAB, QoS class identifiers, QCI, values for each E-RAB associated with the S1-AP session; analyzing, by the processor , S1-AP signaling cause codes associated with the one or more identified dropped calls to identify one or more call drop reasons; and generating, by the processor , an Adaptive Session Intelligence, ASI, data set based on the combined analysis of the S1-AP signaling messages, one or more QCI values and of the S1-AP signaling cause codes, wherein the ASI data set includes one or more metrics indicative of E-RAB status at different stages of a corresponding live call. receiving, by a processor , a plurality of data packets from the wireless communication system ; analyzing, by the processor , S1 - Application Protocol, S1-AP, signaling messages exchanged between the eNodeB and the MME over a first interface for a specified time period and analyzing bearer related events and one or more error codes associated with the bearer related events, the S1-AP signaling messages associated with live calls being made or attempted in the wireless communication system to identify one or more dropped calls; tracking S1-AP session information corresponding to the analyzed S1-AP messages, wherein each tracked S1-AP session maintains one or more E-Radio Access Bearer, E-RAB, QoS class identifiers, QCI, values for each E-RAB associated with the S1-AP session; analyzing, by the processor , S1-AP signaling cause codes associated with the one or more identified dropped calls to identify one or more call drop reasons; and generating, by the processor , an Adaptive Session Intelligence, ASI, data set based on the combined analysis of the S1-AP signaling messages, one or more QCI values and of the S1-AP signaling cause codes, wherein the ASI data set includes one or more metrics indicative of E-RAB status at different stages of a corresponding live call.
A filtering device for separating off particles, in particular particles of a coating material, from a stream of untreated gas that contains particles, wherein the filtering device is a regenerable filtering device that includes an enclosure and at least one filter element that, in a filter operation, is provided with a blocking layer and/or a protective layer including auxiliary filter material, wherein the enclosure delimits an interior space of the filtering device , wherein the at least one filter element is arranged in the interior space of the filtering device , and wherein the stream of untreated gas is configured to be fed to the interior space of the filtering device in an intake direction , through an inlet portion of the filtering device , characterised in that the filtering device includes a screening device that includes at least one screening element , wherein, by means of the at least one screening element , the inlet portion of the filtering device is configured to be covered in certain regions, such that at least one inlet opening and at least one covered screening portion are formed, wherein the screening element forms a web that extends from an upper side of the inlet portion , relative to the direction of gravity (g), to a lower side of the inlet portion , relative to the direction of gravity (g), wherein the at least one screening element is configured such that when the stream of untreated gas flows into the interior space of the filtering device the stream of untreated gas flows around the at least one screening element on two sides, wherein, by means of the at least one screening element , a backflow region and/or a cross-flow region of the stream of untreated gas is configured to be generated on a side of the at least one screening element facing the interior space , and in this backflow region and/or cross-flow region a transport of untreated gas and auxiliary material out of a receiving vessel of the filtering device upwards, in opposition to the direction of gravity (g), to the at least one filter element is not hindered by the stream of untreated gas flowing into the interior space .