A controlled-release multilayer microparticle containing a pharmaceutically active compound, said microparticle being intended for oral administration or direct administration in the stomach in the form of a liquid pharmaceutical composition and said microparticle comprising: - a core comprising the pharmaceutically active compound; - a controlled-release intermediate coating layer; - an outmost external protection coating layer surrounding the controlled-release intermediate coating layer and containing a mixture of a) a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5, advantageously at a pH> 5 and b) a hydrophobic and/or insoluble component wherein the hydrophobic and/or insoluble component is chosen in the group consisting of glycerides, wax, magnesium stearate, fatty alcohol, ethyl cellulose, copolymer based on ethyl acrylate and methyl methacrylate, silicone and stearic acid wherein the outmost external protection coating layer is soluble in the gastric fluid and protects the controlled-release layer from a liquid medium having a pH>6 in which the microparticles are dispersed and wherein the microparticle is not an immediate release microparticle. - a core comprising the pharmaceutically active compound; - a controlled-release intermediate coating layer; - an outmost external protection coating layer surrounding the controlled-release intermediate coating layer and containing a mixture of a) a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5, advantageously at a pH> 5 and b) a hydrophobic and/or insoluble component wherein the hydrophobic and/or insoluble component is chosen in the group consisting of glycerides, wax, magnesium stearate, fatty alcohol, ethyl cellulose, copolymer based on ethyl acrylate and methyl methacrylate, silicone and stearic acid wherein the outmost external protection coating layer is soluble in the gastric fluid and protects the controlled-release layer from a liquid medium having a pH>6 in which the microparticles are dispersed and wherein the microparticle is not an immediate release microparticle. a) a hydrophilic gastro-soluble component which is insoluble in aqueous media at a pH of between 6.5 and 7.5, advantageously at a pH> 5 and b) a hydrophobic and/or insoluble component wherein the hydrophobic and/or insoluble component is chosen in the group consisting of glycerides, wax, magnesium stearate, fatty alcohol, ethyl cellulose, copolymer based on ethyl acrylate and methyl methacrylate, silicone and stearic acid wherein the outmost external protection coating layer is soluble in the gastric fluid and protects the controlled-release layer from a liquid medium having a pH>6 in which the microparticles are dispersed and wherein the microparticle is not an immediate release microparticle. wherein the hydrophobic and/or insoluble component is chosen in the group consisting of glycerides, wax, magnesium stearate, fatty alcohol, ethyl cellulose, copolymer based on ethyl acrylate and methyl methacrylate, silicone and stearic acid wherein the outmost external protection coating layer is soluble in the gastric fluid and protects the controlled-release layer from a liquid medium having a pH>6 in which the microparticles are dispersed and wherein the microparticle is not an immediate release microparticle. <EOS>