mhurhangee/patent-ind-claim-en huggingface dataset:
A method of determining a nucleotide sequence of a template nucleic acid, the method comprising: providing a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; providing a mask layer disposed over the first surface of the substrate, the mask layer covering at least a first portion of the waveguide and comprising a plurality of apertures leaving exposed portions of the waveguide; providing an immobilized polymerase enzyme complex comprising a polymerase enzyme, a template nucleic acid, and a primer which is disposed sufficiently proximal to the first surface and external to the waveguide, to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide, wherein the immobilized polymerase enzyme complex is disposed within an aperture in the mask layer such that a signal from the analyte is spatially optically resolvable from any other signal from an analyte immobilized in another aperture; directing light through the first waveguide such that the evanescent field from the waveguide illuminates the polymerase enzyme complex; exposing the polymerase enzyme complex to a set of labeled nucleotides or nucleotide analogs such that they are incorporated into a nascent strand complementary to the template nucleic acid; and detecting an optical signal from the labelled nucleotides or nucleotide analogs during incorporation into the nascent strand, thereby identifying each of the nucleotides incorporated into the nascent strand. providing a substrate comprising a first surface and at least a first optical waveguide disposed upon the first surface; providing a mask layer disposed over the first surface of the substrate, the mask layer covering at least a first portion of the waveguide and comprising a plurality of apertures leaving exposed portions of the waveguide; providing an immobilized polymerase enzyme complex comprising a polymerase enzyme, a template nucleic acid, and a primer which is disposed sufficiently proximal to the first surface and external to the waveguide, to be illuminated by an evanescent field emanating from the waveguide when light is passed through the waveguide, wherein the immobilized polymerase enzyme complex is disposed within an aperture in the mask layer such that a signal from the analyte is spatially optically resolvable from any other signal from an analyte immobilized in another aperture; directing light through the first waveguide such that the evanescent field from the waveguide illuminates the polymerase enzyme complex; exposing the polymerase enzyme complex to a set of labeled nucleotides or nucleotide analogs such that they are incorporated into a nascent strand complementary to the template nucleic acid; and detecting an optical signal from the labelled nucleotides or nucleotide analogs during incorporation into the nascent strand, thereby identifying each of the nucleotides incorporated into the nascent strand.
A solid rocket propellant grain comprising frontal surfaces and a lateral surface, comprising: a first type layer which is completely filled in cross-section with a solid propellant material with an inhibited lateral surface , and a second type layer which has at least one recess in a solid propellant material with a non-inhibited lateral surface , wherein the solid propellant material is a homogenous solid propellant material, wherein the first and second type layers are cylindrical in shape, and wherein for at least one cylinder of the second type layer, both bottom and upper bases adhere to a base of a first type layer cylinder. a first type layer which is completely filled in cross-section with a solid propellant material with an inhibited lateral surface , and a second type layer which has at least one recess in a solid propellant material with a non-inhibited lateral surface , wherein the solid propellant material is a homogenous solid propellant material, wherein the first and second type layers are cylindrical in shape, and wherein for at least one cylinder of the second type layer, both bottom and upper bases adhere to a base of a first type layer cylinder.
A method of modifying an immobilized capture primer comprising: a. providing a solid support having an immobilized application-specific capture primer, the application-specific capture primer comprising: i. a 3' portion comprising an application-specific capture region, and ii. a 5' portion comprising a universal capture region; b. contacting an application-specific polynucleotide with the application-specific capture primer under conditions sufficient for hybridization to produce an immobilized application-specific polynucleotide, and c. removing the application-specific capture region of an application- specific capture primer not hybridized to an application-specific polynucleotide to convert the unhybridized application-specific capture primer to a universal capture primer. a. providing a solid support having an immobilized application-specific capture primer, the application-specific capture primer comprising: i. a 3' portion comprising an application-specific capture region, and ii. a 5' portion comprising a universal capture region; i. a 3' portion comprising an application-specific capture region, and ii. a 5' portion comprising a universal capture region; b. contacting an application-specific polynucleotide with the application-specific capture primer under conditions sufficient for hybridization to produce an immobilized application-specific polynucleotide, and c. removing the application-specific capture region of an application- specific capture primer not hybridized to an application-specific polynucleotide to convert the unhybridized application-specific capture primer to a universal capture primer.
A computer implemented method of predicting an outcome of a bladder cancer subject or a kidney cancer subject, comprising: - receiving the result of a determination of the gene expression profiles of three or more genes, wherein the three or more genes are selected from: - immune defense response genes selected from the group consisting of: AIM2, APOBEC3A, CIAO1, DDX58, DHX9, IFI16, IFIH1, IFIT1, IFIT3, LRRFIP1, MYD88, OAS1, TLR8, and ZBP1, or - T-Cell receptor signaling genes selected from the group consisting of: CD2, CD247, CD28, CD3E, CD3G, CD4, CSK, EZR, FYN, LAT, LCK, PAG1, PDE4D, PRKACA, PRKACB, PTPRC, and ZAP70, or - PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, or - wherein said three or more genes comprise at least one or more gene(s) selected from each of the immune defense response genes, T-Cell receptor signaling genes and PDE4D7 correlated genes, - wherein the gene expression profiles of the three or more genes are determined in a biological sample obtained from the subject, and - determining the prediction of the outcome based on the gene expression profiles of the three or more genes, and - optionally, providing the prediction to a medical caregiver or the subject. - receiving the result of a determination of the gene expression profiles of three or more genes, wherein the three or more genes are selected from: - immune defense response genes selected from the group consisting of: AIM2, APOBEC3A, CIAO1, DDX58, DHX9, IFI16, IFIH1, IFIT1, IFIT3, LRRFIP1, MYD88, OAS1, TLR8, and ZBP1, or - T-Cell receptor signaling genes selected from the group consisting of: CD2, CD247, CD28, CD3E, CD3G, CD4, CSK, EZR, FYN, LAT, LCK, PAG1, PDE4D, PRKACA, PRKACB, PTPRC, and ZAP70, or - PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, or - wherein said three or more genes comprise at least one or more gene(s) selected from each of the immune defense response genes, T-Cell receptor signaling genes and PDE4D7 correlated genes, - immune defense response genes selected from the group consisting of: AIM2, APOBEC3A, CIAO1, DDX58, DHX9, IFI16, IFIH1, IFIT1, IFIT3, LRRFIP1, MYD88, OAS1, TLR8, and ZBP1, or - T-Cell receptor signaling genes selected from the group consisting of: CD2, CD247, CD28, CD3E, CD3G, CD4, CSK, EZR, FYN, LAT, LCK, PAG1, PDE4D, PRKACA, PRKACB, PTPRC, and ZAP70, or - PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, or - wherein said three or more genes comprise at least one or more gene(s) selected from each of the immune defense response genes, T-Cell receptor signaling genes and PDE4D7 correlated genes, - wherein the gene expression profiles of the three or more genes are determined in a biological sample obtained from the subject, and - determining the prediction of the outcome based on the gene expression profiles of the three or more genes, and - optionally, providing the prediction to a medical caregiver or the subject.
Milling roll of a roll mill having a roll main body and an edge element which is attached to an end region of a roll end of the milling roll and extends in the radial direction beyond the surface of the roll main body , wherein the edge element comprises a base flange and a spacer element which is attached thereto, wherein a plurality of wear protection elements are attached to the spacer element , characterised in that the spacer element is attached between the wear protection element and the base flange .
An electronic device for identifying a LED driver which is a switched mode power supply, comprising: an interface adapted to be coupled to a high frequency power commutation component which is a high frequency switched power inductor of the switched mode power supply, for sensing switching noise components of the high frequency power commutation of the switched mode power supply in driving the LED, wherein said interface comprises a sensor having a sensor module coil adapted to be electromagnetically coupled to the inductor, wherein the interface is adapted to be coupled to a secondary side power inductor of the switched mode power supply which comprises a transformer with a primary side and the secondary side; a processing circuit , for extracting characteristics of the high frequency components, wherein said characteristics comprises one or more frequencies of the switching noise which follows a switching of the switched mode power supply; a database which stores a mapping between identification of LED drivers which are switched mode power supply and said characteristics of the high frequency components of the high frequency power commutations of a respective switched mode power supply in driving the LED; and a controller for looking up an identification of LED driver with a characteristic of the high frequency components of the high frequency power commutation in driving the LED corresponding to the extracted characteristics of the high frequency components of the high frequency power commutations in driving the LED, according to the stored mapping. an interface adapted to be coupled to a high frequency power commutation component which is a high frequency switched power inductor of the switched mode power supply, for sensing switching noise components of the high frequency power commutation of the switched mode power supply in driving the LED, wherein said interface comprises a sensor having a sensor module coil adapted to be electromagnetically coupled to the inductor, wherein the interface is adapted to be coupled to a secondary side power inductor of the switched mode power supply which comprises a transformer with a primary side and the secondary side; a processing circuit , for extracting characteristics of the high frequency components, wherein said characteristics comprises one or more frequencies of the switching noise which follows a switching of the switched mode power supply; a database which stores a mapping between identification of LED drivers which are switched mode power supply and said characteristics of the high frequency components of the high frequency power commutations of a respective switched mode power supply in driving the LED; and a controller for looking up an identification of LED driver with a characteristic of the high frequency components of the high frequency power commutation in driving the LED corresponding to the extracted characteristics of the high frequency components of the high frequency power commutations in driving the LED, according to the stored mapping.
Hollow-chamber profile , in particular window profile or door profile, of thermoplastic material, having an outer wall that is exposed to the weather and an outer wall that faces a room, and having at least one hollow chamber adjacent to the weather side , wherein the outer wall that is exposed to the weather comprises a first thermoplastic material A and at least one other wall (6, 6', 6") of the hollow-chamber profile comprises a second thermoplastic material B, wherein the second thermoplastic material B has a Vicat softening temperature, measured in accordance with DIN EN ISO 306 (B 50), which is at least 5 K higher than that of the first thermoplastic material A, and the second thermoplastic material B has a Vicat softening temperature, measured in accordance with DIN EN ISO 306 (B 50), of at least 85°C, characterised in that the outer wall that is exposed to the weather is formed wholly of the first thermoplastic material A, or the surface that is exposed to the weather of the outer wall that is exposed to the weather is formed by a layer of the first thermoplastic material A.
Centrifugal clutch, of the type including an outer shell for receiving rotation motion of a motor , an internal conducted part , fixed sectors mutually spaced and floating sectors arranged floating in the interspace between the fixed sectors , in which rotation of the outer shell is transmitted to said fixed sectors , in which said floating sectors are suitable for moving radially towards the external side of the clutch until they come into contact with a ring of the conducted part , in which the aforementioned floating sectors are equipped with control devices for holding said floating sectors on the corresponding fixed sectors adjacent to them, which determine the coupling connection and disconnection of the same floating sectors with respect to the fixed sectors , depending on the speed revolution of said outer shell , in which the mentioned control devices consist of springs positioned in correspondence with said floating sectors and provided at their ends with spheres that snap fit into respective locations provided on the corresponding sides of the fixed sectors , in the engagement position of said clutch the spheres being arranged in an unstable equilibrium condition on the edge of the aforementioned locations of the fixed sectors so that, when the speed revolution of said outer shell is less than a predetermined value, there is a corresponding decrease in the centrifugal force, which allows the springs to recall the spheres within their locations in the same fixed sectors .
A landing-door door lock device, comprising a primary lock and a secondary lock, wherein the primary lock comprises a bottom plate and a locking arm , a counter weight is mounted on the locking arm , a moving ball is fixed onto the counter weight , a fixed ball is mounted on the bottom plate , and the secondary lock comprises a buckle plate , wherein the locking arm is rotationally connected onto the bottom plate through a rotary shaft , a rear end of the locking arm is provided with a first kidney-shaped hole , characterized in that the counter weight is fixed with the locking arm through the first kidney-shaped hole , an arc-shaped hole is opened on the counter weight , a shaft sleeve is sheathed on a shaft of the fixed ball , the shaft sleeve penetrates into the arc-shaped hole , a second kidney-shaped hole is opened on the bottom plate , the fixed ball is fixed with the bottom plate through the second kidney-shaped hole , a front end of the buckle plate is provided with a first lock hook , the locking arm is correspondingly provided thereon with a lock column , and the first lock hook is buckled on the lock column .
A dilutable concentrate for hard surface cleaners with improved film/streak performance on high-energy surfaces selected from glass or ceramic tiles, comprising: a) 25 to 95 wt.% of a nonionic alkoxylated surfactant; b) 2 to 30 wt.% of a polyetheramine comprising at least one primary amino group and having a number-average molecular weight within the range of 300 to 5,000 g/mol and at least 50 mole% of oxypropylene units, oxybutylene units or both, based on the combined amounts of oxyalkylene units; and c) optionally, up to 50 wt.% of a cosolvent, a builder, an auxiliary surfactant, or a mixture thereof, said wt.% values based on the amount of dilutable concentrate. a) 25 to 95 wt.% of a nonionic alkoxylated surfactant; b) 2 to 30 wt.% of a polyetheramine comprising at least one primary amino group and having a number-average molecular weight within the range of 300 to 5,000 g/mol and at least 50 mole% of oxypropylene units, oxybutylene units or both, based on the combined amounts of oxyalkylene units; and c) optionally, up to 50 wt.% of a cosolvent, a builder, an auxiliary surfactant, or a mixture thereof, said wt.% values based on the amount of dilutable concentrate.
A liquid container 2 comprising a rigid planar material defining first 8 and second faces 10 interconnected by at least two connecting edges 11, 13, each face 8, 10 having an inner surface and an outer surface, wherein the container is configured to be converted, upon application of substantially opposing forces to two sides of the container 2, from a planar configuration 122, in which the inner surface of the first face 8 is substantially adjacent to the inner surface of the second face 10, to an open configuration, in which the inner surfaces of the first and second faces 8, 10 are spaced apart and which, in combination with the at least two connecting edges 11, 13, define a volume therebetween for containing liquid, the container 2 comprises locking means configured to hold the container in the open configuration 124, and wherein the locking means comprises a tab 26 disposed in the first face 8, and a first aperture 118 disposed in the second face 10, wherein the first aperture 118 is configured to receive the tab 26, thereby holding the container 2 in the open configuration 124, and characterised in that the at least two connecting edges 11, 13 comprise three connecting edges, and the three connecting edges comprise first, second and third side edges, wherein the third side edge intersects both the first and second side edges.
Communication device containing - a device, which is in the form of a movement module (31; 41), for mechanically generating a rotational movement, wherein the movement module (31; 41) is provided with a drive rod and a pushbutton for generating a linear movement of the drive rod and also with at least one gear wheel which acts on the drive rod and, in the event of a linear movement of the drive rod , is set in rotational motion, - a converter module (32; 42) which is connected to the movement module (31; 41), wherein the converter module (32; 42) converts the rotational movement which is generated in the movement module (31; 41) into electrical energy, - an energy management module (34; 47), which is connected to the converter module (32; 42), for providing electrical energy in line with prespecified boundary conditions based on the electrical energy which is provided by the converter module (32; 42), and - a transmission module (35; 48) for transmitting information, characterized in that either the drive rod , at least in sections, is in the form of a worm shaft and the gear wheel is in the form of a worm gear or the drive rod , at least in sections, is provided with a screw thread and the gear wheel has a spur toothing system. - a device, which is in the form of a movement module (31; 41), for mechanically generating a rotational movement, wherein the movement module (31; 41) is provided with a drive rod and a pushbutton for generating a linear movement of the drive rod and also with at least one gear wheel which acts on the drive rod and, in the event of a linear movement of the drive rod , is set in rotational motion, - a converter module (32; 42) which is connected to the movement module (31; 41), wherein the converter module (32; 42) converts the rotational movement which is generated in the movement module (31; 41) into electrical energy, - an energy management module (34; 47), which is connected to the converter module (32; 42), for providing electrical energy in line with prespecified boundary conditions based on the electrical energy which is provided by the converter module (32; 42), and - a transmission module (35; 48) for transmitting information, characterized in that either the drive rod , at least in sections, is in the form of a worm shaft and the gear wheel is in the form of a worm gear or the drive rod , at least in sections, is provided with a screw thread and the gear wheel has a spur toothing system.
Use of a composition comprising at least one source of oxygen free radicals and at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals, wherein said at least one source of oxygen free radicals is hydrogen peroxide and said at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals is ascorbic acid or a salt thereof, for the in vivo degradation of polysaccharide-containing fillers for cosmetic purposes..
An abraded wire detection system 'AWDS' adapted for detecting an abrasion on an insulated wire in a fuel tank , the AWDS comprising: a power source configured to apply a voltage signal on the insulated wire ; an electrode in electrical series with a fuel tank wall of the fuel tank , wherein the electrode is configured for receiving a current corresponding to the voltage signal ; and a current sensor in electrical series with the power source , the insulated wire , and the electrode , wherein the current sensor includes circuitry that is configured to detect a current from the insulated wire to the electrode . a power source configured to apply a voltage signal on the insulated wire ; an electrode in electrical series with a fuel tank wall of the fuel tank , wherein the electrode is configured for receiving a current corresponding to the voltage signal ; and a current sensor in electrical series with the power source , the insulated wire , and the electrode , wherein the current sensor includes circuitry that is configured to detect a current from the insulated wire to the electrode .