mhurhangee/patent-ind-claim-en huggingface dataset:
A method of characterizing DNA in a biological sample, the method comprising: (a) isolating fragments of DNA from a biological sample; (b) constructing a library comprising said fragments; (c) sequencing the library, wherein the sequencing comprises whole genome sequencing; and (d) detecting alterations in the fragmentation pattern in cell free DNA (cfDNA) and fragmented genomic DNA (gDNA) from the biological sample, wherein the fragmentation pattern in each DNA fragment identifies the DNA methylation pattern with single base pair resolution; wherein detecting alterations in the fragmentation pattern comprises detecting alterations in fragment length, fragment coverage, and distance to fragment end in the cfDNA and the fragmented gDNA, wherein the fragmentation pattern in each DNA fragment identifies the DNA methylation pattern, thereby indicating that at least a fragment of the DNA in the sample was derived from a diseased cell or was derived from a healthy cell. (a) isolating fragments of DNA from a biological sample; (b) constructing a library comprising said fragments; (c) sequencing the library, wherein the sequencing comprises whole genome sequencing; and (d) detecting alterations in the fragmentation pattern in cell free DNA (cfDNA) and fragmented genomic DNA (gDNA) from the biological sample, wherein the fragmentation pattern in each DNA fragment identifies the DNA methylation pattern with single base pair resolution;
A method for synthetic representation of elements of interest in a display system for an aircraft, said display system comprising at least location sensors of said aircraft, a first cartographic database , a second elements of interest database , an image sensor , a unit for processing images originating from said image sensor, a unit for generating three-dimensional digital images representing the terrain that is flown over by the aircraft as a function of data originating from the location sensors, the two cartographic and elements of interest databases and the image processing unit and a display device , characterised in that , when the terrain that is flown over comprises at least one element of interest that is present in the elements of interest database, said element being displayed in the three-dimensional digital images representing the terrain that is flown over, said synthetic representation method comprises at least: - a first step of searching and detecting said element of interest in each image of a sequence of images originating from the image sensor, the detection being performed by the processing unit; and - a second step of generating three-dimensional digital images representing the terrain that is flown over, the element of interest being represented according to a first representation if it has not been detected in any of the images of the sequence of images originating from the image sensor and according to a second representation if it is detected in at least one image of the sequence of images. - a first step of searching and detecting said element of interest in each image of a sequence of images originating from the image sensor, the detection being performed by the processing unit; and - a second step of generating three-dimensional digital images representing the terrain that is flown over, the element of interest being represented according to a first representation if it has not been detected in any of the images of the sequence of images originating from the image sensor and according to a second representation if it is detected in at least one image of the sequence of images.
Device for treating the hair comprising two arms that are movable with respect to one another between a moved-together configuration for treating the hair and a spaced-apart configuration for introducing hair to be treated between said arms, one of the arms comprising a housing designed to receive a removable refill for treating the hair, the hair treatment refill comprising a refill body and an application member fixed to the refill body , the connection between the refill and the arm being locked by means of a locking device of the push-release type, comprising: - a female element belonging to one of either the refill or the arm that receives the refill, and - a male element belonging to the other of either the refill or the arm that receives the refill, the male element being locked with respect to a female element by a simple relative movement in translation of the male element with respect to the female element in one direction and one sense, and unlocked with respect to the female element by a relative movement in translation of the male element with respect to the female element in the same direction and the same sense. - a female element belonging to one of either the refill or the arm that receives the refill, and - a male element belonging to the other of either the refill or the arm that receives the refill, the male element being locked with respect to a female element by a simple relative movement in translation of the male element with respect to the female element in one direction and one sense, and unlocked with respect to the female element by a relative movement in translation of the male element with respect to the female element in the same direction and the same sense.
A safety device for preventing overcurrent, comprising: a first heat dissipation portion made of an electrically conductive material; a second heat dissipation portion made of an electrically conductive material; and a connecting part made of an electrically conductive material arranged between the first heat dissipation portion and the second heat dissipation portion , and provided with at least one heat locking hole , wherein the connecting part has a first heat locking portion , a fusing portion , and a second heat locking portion , and wherein the at least one heat locking hole is located in the first heat locking portion and/or the second heat locking portion , characterized in that each of the first heat dissipation portion and the second heat dissipation portion is provided with a mounting pin and at least an auxiliary pin , both mounting pins and the auxiliary pins being suitable for mounting the safety device on a printed circuit board . a first heat dissipation portion made of an electrically conductive material; a second heat dissipation portion made of an electrically conductive material; and a connecting part made of an electrically conductive material arranged between the first heat dissipation portion and the second heat dissipation portion , and provided with at least one heat locking hole , wherein the connecting part has a first heat locking portion , a fusing portion , and a second heat locking portion , and wherein the at least one heat locking hole is located in the first heat locking portion and/or the second heat locking portion , characterized in that each of the first heat dissipation portion and the second heat dissipation portion is provided with a mounting pin and at least an auxiliary pin , both mounting pins and the auxiliary pins being suitable for mounting the safety device on a printed circuit board .
Method for heating plastic preforms , wherein the plastic preforms are transported along a predetermined transport path (P) and are heated during this transport, wherein at least one first heating section with at least one first heating element as well as at least one second heating section with at least one second heating element is arranged along the transport path, wherein by means of a first temperature measuring device an actual temperature (T l ) of the plastic preforms is measured in or before a start region of the transport path (P), and as a function of this actual temperature (T l ) of the plastic preforms the at least one first heating element is controlled in such a way that the plastic preforms reach a predetermined target temperature (Ts) after heating by this at least one first heating element , characterised in that a material constant of the plastic preforms is determined, wherein in this determination of the material constant at least a mass of the plastic preforms, an absorption coefficient of the plastic preforms and a specific thermal capacity of the plastic preforms is taken into consideration, wherein the determined material constant is taken into consideration during the heating of the plastic preforms. wherein by means of a first temperature measuring device an actual temperature (T l ) of the plastic preforms is measured in or before a start region of the transport path (P), and as a function of this actual temperature (T l ) of the plastic preforms the at least one first heating element is controlled in such a way that the plastic preforms reach a predetermined target temperature (Ts) after heating by this at least one first heating element , characterised in that a material constant of the plastic preforms is determined, wherein in this determination of the material constant at least a mass of the plastic preforms, an absorption coefficient of the plastic preforms and a specific thermal capacity of the plastic preforms is taken into consideration, wherein the determined material constant is taken into consideration during the heating of the plastic preforms.
A rubber tube characterized by having an inner surface roughened so that a ratio R/D of an inner surface roughness R (as specified in JIS B0601) of the tube to an inner diameter D of the tube is not less than a predetermined level, where in the inner surface roughness R is a maximum height Rz, and a ratio Rz/D is not less than 0.038; or the inner surface roughness R is a maximum peak height Rp, and a ratio Rp/D is not less than 0.019; or the inner surface roughness R is a maximum valley depth Rv, and a ratio Rv/D is not less than 0.019; or the inner surface roughness R is an arithmetic average roughness Ra, and a ratio Ra/D is not less than 0.0036; or the inner surface roughness R is a root mean square height Rq, and a ratio Rq/D is not less than 0.0046.
A positioning method, comprising: sending (S401, S504), by a positioning management network element, a positioning measurement request to a positioning measurement network element, wherein the positioning measurement request is used to request the positioning measurement network element to feed back channel state information of a terminal device; receiving (S402, S507), by the positioning management network element, a positioning measurement response from the positioning measurement network element, wherein the positioning measurement response comprises the channel state information of the terminal device; and determining (S403, S508), by the positioning management network element, a location of the terminal device based on the channel state information of the terminal device; the method being characterized in that the positioning management network element determines the location of the terminal device based on a correspondence between the channel state information of the terminal device and location information, wherein the correspondence is a pre-established one-to-one correspondence between a plurality of preset locations and a plurality of pieces of preset channel state information, and wherein the location of the terminal device is determined based on a result of matching between the channel state information of the terminal device and the plurality of pieces of preset channel state information. sending (S401, S504), by a positioning management network element, a positioning measurement request to a positioning measurement network element, wherein the positioning measurement request is used to request the positioning measurement network element to feed back channel state information of a terminal device; receiving (S402, S507), by the positioning management network element, a positioning measurement response from the positioning measurement network element, wherein the positioning measurement response comprises the channel state information of the terminal device; and determining (S403, S508), by the positioning management network element, a location of the terminal device based on the channel state information of the terminal device; the method being characterized in that the positioning management network element determines the location of the terminal device based on a correspondence between the channel state information of the terminal device and location information, wherein the correspondence is a pre-established one-to-one correspondence between a plurality of preset locations and a plurality of pieces of preset channel state information, and wherein the location of the terminal device is determined based on a result of matching between the channel state information of the terminal device and the plurality of pieces of preset channel state information.
A diagnostic probe designed to be introduced into a bodily, vaginal or rectal endocavity of the human body and to allow, in response to an increase in intra-abdominal pressure, at least the measurement of the displacement of the walls of said endocavity and of the organs which surround it as well as the measurement of the displacement and of the passive and active resistance of at least one muscle of the perineum, the diagnostic probe comprising an ex-vivo base configured to be arranged at the opening of the endocavity, and connected to an intracavitary body equipped with at least two pressure sensors arranged in the same plane, and acting either in the same direction, or in two opposite directions, the intracavitary body being designed to be deformable without opposing resistance and to conform to the walls of said endocavity, the diagnostic probe comprising: - at least one means for measuring the displacement of the intracavitary wall in the three axes X, Y and Z, said at least one means for measuring the displacement of the intracavitary wall being arranged on the intracavitary body ; and - a means for measuring the displacement of the perineum muscles along three axes X, Y, Z, said means for measuring the displacement of the perineum muscles being arranged on the base ; said at least one means for measuring the displacement of the intracavitary wall being connected to at least one spatial reference element X, Y, Z, and said means for measuring the displacement of the perineum muscles being connected to a spatial reference element X, Y, Z. - at least one means for measuring the displacement of the intracavitary wall in the three axes X, Y and Z, said at least one means for measuring the displacement of the intracavitary wall being arranged on the intracavitary body ; and - a means for measuring the displacement of the perineum muscles along three axes X, Y, Z, said means for measuring the displacement of the perineum muscles being arranged on the base ;
A compound represented by the following structural formula or a pharmaceutically acceptable salt thereof, for use in a method of treating a subject with Fabry disease, the method comprising: testing the subject to determine whether the subject is a poor, intermediate or extensive/ultra rapid P450 metabolizer, wherein the subject is assessed as being a poor, intermediate or extensive/ultra rapid P450 metabolizer through genotyping, wherein a poor P450 metabolizer carries two mutant alleles of the CYP2D6 gene which result in complete loss of enzyme activity, an intermediate P450 metabolizer possesses one reduced activity allele and one null allele of the CYP2D6 gene, an extensive P450 metabolizer possesses at least one and no more than two normal functional alleles of the CYP2D6 gene, and an ultra rapid P450 metabolizer carries multiple copies of functional alleles of the CYP2D6 gene and produces excess enzymatic activity; and administering to the subject an adjusted effective amount of the compound if the subject is an intermediate or extensive/ultra rapid P450 metabolizer and administering to the subject an effective amount of the compound if the subject is a poor P450 metabolizer, wherein said effective amount is a daily dose of from 25 milligrams to 300 milligrams, and wherein said adjusted effective amount is greater than said effective amount. testing the subject to determine whether the subject is a poor, intermediate or extensive/ultra rapid P450 metabolizer, wherein the subject is assessed as being a poor, intermediate or extensive/ultra rapid P450 metabolizer through genotyping, wherein a poor P450 metabolizer carries two mutant alleles of the CYP2D6 gene which result in complete loss of enzyme activity, an intermediate P450 metabolizer possesses one reduced activity allele and one null allele of the CYP2D6 gene, an extensive P450 metabolizer possesses at least one and no more than two normal functional alleles of the CYP2D6 gene, and an ultra rapid P450 metabolizer carries multiple copies of functional alleles of the CYP2D6 gene and produces excess enzymatic activity; and administering to the subject an adjusted effective amount of the compound if the subject is an intermediate or extensive/ultra rapid P450 metabolizer and administering to the subject an effective amount of the compound if the subject is a poor P450 metabolizer, wherein said effective amount is a daily dose of from 25 milligrams to 300 milligrams, and wherein said adjusted effective amount is greater than said effective amount.
A seal ring for a variable valve timing system comprising a camshaft for driving an intake valve of an internal combustion engine and an exhaust valve thereof; an inner rotational body fixed to said camshaft ; an outer rotational body making a rotational motion relative to said inner rotational body by supply of hydraulic oil at a time of altering opening and closing timings of said intake valve and said exhaust valve; and a shaft body mounted on an inner circumference of said inner rotational body concentrically with said inner rotational body and said outer rotational body, wherein the seal ring is for sealing annular passages formed between said inner rotational body and said shaft body , which serve as an oil passage of said hydraulic oil, by mounting on a sectionally rectangular annular groove formed on said shaft body , and characterised in that said seal ring is an annular body approximately rectangular in a sectional view and comprises a molding of a polyphenylene sulfide resin composition containing polyphenylene sulfide resin as a main component thereof and an elastomer.
An elevator system, comprising: an elevator car , a hoisting machine moving the elevator car in a hoistway , the hoisting machine comprises a brake unit with several separate brakes operated together to reduce speed of the elevator car , an acceleration sensor connected to the hoisting machine , and a computing unit which is responsive to a signal provided by the acceleration sensor and which sends condition data based on a predetermined processing of the signal, characterized in that the elevator system comprises a brake control circuit separately controlling the brakes into a brake position and into a release position, and the brake control circuit is configured to control the brakes to move their brake armatures in turns to provide condition data where information originating from the separate brakes can be identified. an elevator car , a hoisting machine moving the elevator car in a hoistway , the hoisting machine comprises a brake unit with several separate brakes operated together to reduce speed of the elevator car , an acceleration sensor connected to the hoisting machine , and a computing unit which is responsive to a signal provided by the acceleration sensor and which sends condition data based on a predetermined processing of the signal, characterized in that the elevator system comprises a brake control circuit separately controlling the brakes into a brake position and into a release position, and the brake control circuit is configured to control the brakes to move their brake armatures in turns to provide condition data where information originating from the separate brakes can be identified.
A pharmaceutical composition comprising, a) (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone and pharmaceutically acceptable salts thereof, b) basic pre-treated low molecular weight polyethylene glycol comprising one or more of PEG 200, PEG 300, PEG 400, PEG 600 and/or PEG 800; c) undiluted pH of about 11.0 to about 14.0; and d) less than 5% water or aqueous solution for example less than or equal to 2% water or aqueous solution. a) (E)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4-methoxybenzylsulphone and pharmaceutically acceptable salts thereof, b) basic pre-treated low molecular weight polyethylene glycol comprising one or more of PEG 200, PEG 300, PEG 400, PEG 600 and/or PEG 800; c) undiluted pH of about 11.0 to about 14.0; and d) less than 5% water or aqueous solution for example less than or equal to 2% water or aqueous solution.
Plug-in connector part for plug-connection to an associated mating plug-in connector part for a charging system for charging an electric vehicle, comprising a housing part , a plug-in face which is formed on the housing part and by means of which the plug-in connector part can be plug-connected to the mating plug-in connector part and on which a plurality of contact elements for electrical connection to the mating plug-in connector part are arranged, comprising a printed circuit board on which at least one electrical or electronic functional component is arranged, and comprising a load contact carrier which is connected to the housing part and on which a first contact element of the plurality of contact elements is arranged, wherein the printed circuit board has a first opening through which the first contact element is extended, wherein the printed circuit board has at least one first contact spring for making thermal and/or electrical contact with the first contact element and at least one second contact spring for making thermal and/or electrical contact with a second contact element of the plurality of contact elements , characterized by a signal contact carrier which passes through the printed circuit board at a first passage opening for fixing the second contact element to the housing part , wherein, for the purpose of assembling the plug-in connector part , the printed circuit board , together with the signal contact carrier and the load contact carrier , is inserted into a receiving space of the housing part in such a way that the printed circuit board , by way of the at least one second contact spring , comes in contact with an end of the at least one second contact element .