mhurhangee/patent-ind-claim-en huggingface dataset:
An embolic protection delivery device comprising: a balloon catheter having an inflatable balloon and first and second ends; an embolic protection device comprising first and second ends, the embolic protection device comprising a frame and a filter sheet attached to the frame, the frame being expandable from a compact state to an expanded state in which the second end has a diameter larger than the first end to form a conical shape, the frame comprising a plurality of U-shaped members disposed at the second end of the embolic protection device and a plurality of leg members each coupled to a respective U-shaped member; a first sheath comprising a first inner lumen configured to receive at least a portion of the embolic protection device when the embolic protection device is in the compact state, the first sheath being distally movable relative to the embolic protection device to permit the second end of the embolic protection device to expand to the expanded state; a second sheath comprising a second inner lumen configured to receive at least a portion of the embolic protection device when the balloon is in an uninflated state, the second sheath being proximally movable relative to the balloon to permit the balloon to be inflated, wherein in the expanded state, the embolic protection device is manipulable independent of the balloon catheter such that the U-shaped members seat against native valve leaflet sinuses of a native valve annulus, the second sheath being thereafter proximally movable to permit the balloon to be inflated against a native valve leaflet. a balloon catheter having an inflatable balloon and first and second ends; an embolic protection device comprising first and second ends, the embolic protection device comprising a frame and a filter sheet attached to the frame, the frame being expandable from a compact state to an expanded state in which the second end has a diameter larger than the first end to form a conical shape, the frame comprising a plurality of U-shaped members disposed at the second end of the embolic protection device and a plurality of leg members each coupled to a respective U-shaped member; a first sheath comprising a first inner lumen configured to receive at least a portion of the embolic protection device when the embolic protection device is in the compact state, the first sheath being distally movable relative to the embolic protection device to permit the second end of the embolic protection device to expand to the expanded state; a second sheath comprising a second inner lumen configured to receive at least a portion of the embolic protection device when the balloon is in an uninflated state, the second sheath being proximally movable relative to the balloon to permit the balloon to be inflated, wherein in the expanded state, the embolic protection device is manipulable independent of the balloon catheter such that the U-shaped members seat against native valve leaflet sinuses of a native valve annulus, the second sheath being thereafter proximally movable to permit the balloon to be inflated against a native valve leaflet.
An intraocular lens injector for injecting an intraocular lens into an eye, comprising: a hollow body ; a lens setting portion provided inside the hollow body ; a slider for advancing an intraocular lens that has been set on the lens setting portion ; and a rod for further advancing the intraocular lens that has been advanced using the slider , wherein, when a side in the optical axis direction (Z-direction) of the intraocular lens that comes into contact with the lens setting portion when the intraocular lens is set on the lens setting portion is defined as a bottom side (direction Z2), a side opposite to the bottom side is defined as a top side (direction Z1), a side toward which the intraocular lens is advanced is defined as a front side (direction X1), a side opposite to the front side is defined as a rear side (direction X2), and a direction orthogonal to the Z-direction and X-direction is defined as a width direction (Y-direction), and wherein the hollow body defines an inner-circumference lower portion and an inner-circumference upper portion, characterized by a space that extends downwardly from the inner-circumference lower portion and into which a part of a rear side of the intraocular lens is capable of moving downward is provided at a position α on the inner-circumference lower portion of the hollow body , and a front limit (L) of a range of motion of a portion of the slider that abuts against an outer circumference of an optical portion of the intraocular lens is located above the position α. a hollow body ; a lens setting portion provided inside the hollow body ; a slider for advancing an intraocular lens that has been set on the lens setting portion ; and a rod for further advancing the intraocular lens that has been advanced using the slider , wherein, when a side in the optical axis direction (Z-direction) of the intraocular lens that comes into contact with the lens setting portion when the intraocular lens is set on the lens setting portion is defined as a bottom side (direction Z2), a side opposite to the bottom side is defined as a top side (direction Z1), a side toward which the intraocular lens is advanced is defined as a front side (direction X1), a side opposite to the front side is defined as a rear side (direction X2), and a direction orthogonal to the Z-direction and X-direction is defined as a width direction (Y-direction), and wherein the hollow body defines an inner-circumference lower portion and an inner-circumference upper portion, characterized by a space that extends downwardly from the inner-circumference lower portion and into which a part of a rear side of the intraocular lens is capable of moving downward is provided at a position α on the inner-circumference lower portion of the hollow body , and a front limit (L) of a range of motion of a portion of the slider that abuts against an outer circumference of an optical portion of the intraocular lens is located above the position α.
A computing device , comprising: a processor ; a touch-screen ; and a memory in operable communication with the processor and the touch-screen , the memory including instructions that upon execution by the processor cause the processor to: display a first notification at a first position on the touch-screen and a second notification at a second position on the touch-screen; change a position of the first notification to overlap at least a portion of the second notification based on touch input sensed by the touch-screen; select the first notification and the second notification based on a sensed position of a first touch input, namely, in response to determining that a threshold amount of the first notification was overlaid upon the second notification; and dismiss both the first notification and the second notification in response to detecting a dismissal gesture. a processor ; a touch-screen ; and a memory in operable communication with the processor and the touch-screen , the memory including instructions that upon execution by the processor cause the processor to: display a first notification at a first position on the touch-screen and a second notification at a second position on the touch-screen; change a position of the first notification to overlap at least a portion of the second notification based on touch input sensed by the touch-screen; select the first notification and the second notification based on a sensed position of a first touch input, namely, in response to determining that a threshold amount of the first notification was overlaid upon the second notification; and dismiss both the first notification and the second notification in response to detecting a dismissal gesture. display a first notification at a first position on the touch-screen and a second notification at a second position on the touch-screen; change a position of the first notification to overlap at least a portion of the second notification based on touch input sensed by the touch-screen; select the first notification and the second notification based on a sensed position of a first touch input, namely, in response to determining that a threshold amount of the first notification was overlaid upon the second notification; and dismiss both the first notification and the second notification in response to detecting a dismissal gesture.
A die-casting method in which a melt is forwarded under the influence of a pressure difference from a hermetically sealed lower chamber and/or a lower pressure compartment and/or a furnace interior of a furnace through a riser tube, filling the cavity of a casting mold, where the cast piece solidifies and after which it is removed from the casting mold, characterized in that the pressure supply of the lower chamber and/or of the lower pressure compartment and/or furnace interior takes place via two valves that are switched in a parallel manner, namely via a first valve for a main charge of the pressure compartment and via a second valve for the precise pressure adjustment inside the pressure compartment, wherein the first valve is larger than the second valve.
A repositionable linerless thermal label comprising: a paper substrate having a first surface and a second surface , wherein said substrate is either i) a thermochromic paper or ii) includes a print layer on its second surface , wherein said print layer includes a thermal transfer receptive coating suitable for thermal transfer printing and/or includes one or more thermally sensitive coatings which are adapted to change color upon application of heat thereto by direct thermal printing; at least one heat-activated adhesive patch applied to the first surface of the substrate , wherein said adhesive patch includes microspheres; and a silicone-free water-based release coating comprising 5% or less of silicone applied to the second surface of the substrate or, if the print layer is present, to the outer surface of the print layer . a paper substrate having a first surface and a second surface , wherein said substrate is either i) a thermochromic paper or ii) includes a print layer on its second surface , wherein said print layer includes a thermal transfer receptive coating suitable for thermal transfer printing and/or includes one or more thermally sensitive coatings which are adapted to change color upon application of heat thereto by direct thermal printing; at least one heat-activated adhesive patch applied to the first surface of the substrate , wherein said adhesive patch includes microspheres; and a silicone-free water-based release coating comprising 5% or less of silicone applied to the second surface of the substrate or, if the print layer is present, to the outer surface of the print layer .
An implantable device for intraocular drug delivery comprising at least two hollow solids inscribed one into the other, and at least one closing element, where the walls of said at least two hollow solids are made of biodegradable material based on magnesium, and where said at least two hollow solids inscribed one into the other delimit a volume, called core, inside the innermost of said hollow solids and one or more volumes, called crown (s), comprised between said innermost hollow solid and the hollow solid at the exterior thereof, wherein said walls are impermeable continuous walls which become permeable as a function of the post-implantation time of said device, said hollow solids inscribed one into the other are arranged so as to have an upper base and/or a lower base in common, said core and said crowns (s) having at least one opening toward an outside, said at least one opening being said upper base and/or lower base; said core and said crown (s) being closed to the outside by said at least one closing element.
An apparatus comprising means for: determining whether a user distraction criterion has been met, the user distraction criterion relating to use of a user device , by a first user , exceeding a threshold level; determining whether a presence criterion has been met, the presence criterion relating to: a proximity of at least a second user to the user device being below a threshold level, and/or a proximity of the at least second user to the first user being below a threshold level; determining use, by a third user , of another user device ; determining whether at least a second user distraction criterion has been met, the at least second user distraction criterion relating to use, by the third user , of the another user device ; determining a proximity of: the another user device to the at least second user , and/or the third user to the at least second user ; determining whether a second presence criterion has been met, the second presence criterion relating to a proximity of the third user to the at least second user ; and responsive to determining that the first and at least second user distraction criteria and the first and second presence criteria have been met, causing the triggering of a function on the user device and/or the another user device . determining whether a user distraction criterion has been met, the user distraction criterion relating to use of a user device , by a first user , exceeding a threshold level; determining whether a presence criterion has been met, the presence criterion relating to: a proximity of at least a second user to the user device being below a threshold level, and/or a proximity of the at least second user to the first user being below a threshold level; a proximity of at least a second user to the user device being below a threshold level, and/or a proximity of the at least second user to the first user being below a threshold level; determining use, by a third user , of another user device ; determining whether at least a second user distraction criterion has been met, the at least second user distraction criterion relating to use, by the third user , of the another user device ; determining a proximity of: the another user device to the at least second user , and/or the third user to the at least second user ; the another user device to the at least second user , and/or the third user to the at least second user ; determining whether a second presence criterion has been met, the second presence criterion relating to a proximity of the third user to the at least second user ; and responsive to determining that the first and at least second user distraction criteria and the first and second presence criteria have been met, causing the triggering of a function on the user device and/or the another user device .
A device for leakage testing of a connection between a rubber stopper and a corresponding drug container , wherein the device comprises - a displacement device and - a drug container receptacle , wherein - the drug container receptacle is a receptacle for receiving at least part of the drug container , which has a dispensing opening and a communication opening for enabling fluid communication of the exterior of the drug container with an interior of the drug container apart from its dispensing opening , when the rubber stopper is inserted into the dispensing opening , characterized in that - the displacement device is a device for providing a displacement of the rubber stopper , which is inserted into the dispensing opening of the drug container , relative to the drug container in an opening direction , and - the displacement device comprises a support member for supporting the displacement device against the drug container and a movement member for supporting the displacement device against the rubber stopper , wherein the movement member is movable relative to the support member in the opening direction . - a displacement device and - a drug container receptacle , wherein - the drug container receptacle is a receptacle for receiving at least part of the drug container , which has a dispensing opening and a communication opening for enabling fluid communication of the exterior of the drug container with an interior of the drug container apart from its dispensing opening , when the rubber stopper is inserted into the dispensing opening , characterized in that - the displacement device is a device for providing a displacement of the rubber stopper , which is inserted into the dispensing opening of the drug container , relative to the drug container in an opening direction , and - the displacement device comprises a support member for supporting the displacement device against the drug container and a movement member for supporting the displacement device against the rubber stopper , wherein the movement member is movable relative to the support member in the opening direction .
A method of increasing transcription of a target gene sequence in a human cell, the method comprising: contacting the human cell with a fusion protein, wherein the fusion protein comprises: a DNA-binding domain comprising a transcription activator-like effector (TALE) repeat array that binds specifically to a subsequence of the target gene sequence, and a transactivation domain that increases transcription of the target gene sequence, wherein: the subsequence is within a DNase I hypersensitive region of a regulatory region of the target gene sequence; the subsequence is 18-24 nucleotides long; the first nucleotide of the subsequence is a thymine; and the second nucleotide in the subsequence is an adenosine, the last nucleotide in the subsequence is a thymine, and/or the base composition percentage of the subsequence is other than 0-63% adenine, other than 11-63% cytosine, other than 0-25% guanine, or other than 2-42% thymine; thereby increasing transcription of the target gene sequence in the human cell. contacting the human cell with a fusion protein, wherein the fusion protein comprises: a DNA-binding domain comprising a transcription activator-like effector (TALE) repeat array that binds specifically to a subsequence of the target gene sequence, and a transactivation domain that increases transcription of the target gene sequence, wherein: the subsequence is within a DNase I hypersensitive region of a regulatory region of the target gene sequence; the subsequence is 18-24 nucleotides long; the first nucleotide of the subsequence is a thymine; and a DNA-binding domain comprising a transcription activator-like effector (TALE) repeat array that binds specifically to a subsequence of the target gene sequence, and a transactivation domain that increases transcription of the target gene sequence, wherein: the subsequence is within a DNase I hypersensitive region of a regulatory region of the target gene sequence; the subsequence is 18-24 nucleotides long; the first nucleotide of the subsequence is a thymine; and the subsequence is within a DNase I hypersensitive region of a regulatory region of the target gene sequence; the subsequence is 18-24 nucleotides long; the first nucleotide of the subsequence is a thymine; and the second nucleotide in the subsequence is an adenosine, the last nucleotide in the subsequence is a thymine, and/or the base composition percentage of the subsequence is other than 0-63% adenine, other than 11-63% cytosine, other than 0-25% guanine, or other than 2-42% thymine; thereby increasing transcription of the target gene sequence in the human cell.
A temporary inhibitor of p53 for use for preventing or reducing cancer relapse in cancer patients, wherein the temporary inhibitor of p53 is used in combination with an anti-cancer treatment, said anti-cancer treatment being a radiation or an anti-cancer agent, and wherein the temporary inhibitor of p53 is chosen from pifithrin-alpha, pifithrin -μ, and cyclic pifithrin-alpha hydrobromide. wherein the temporary inhibitor of p53 is used in combination with an anti-cancer treatment, said anti-cancer treatment being a radiation or an anti-cancer agent, and wherein the temporary inhibitor of p53 is chosen from pifithrin-alpha, pifithrin -μ, and cyclic pifithrin-alpha hydrobromide.
Hopper dredger comprising an overflow system for draining away head water standing above settled fractions in a dredge loading space, the overflow system comprising: - an inlet for taking in head water; - a filtering device with at least one filtering layer , fluidly coupled with the inlet so that the head water entering the inlet flows through the at least one filtering layer and the at least one filtering layer filters at least some suspended fractions from the head water by allowing head water through the filtering layer but preventing the at least some suspended fractions from flowing through with the head water; - a fractions outlet coupled with the filtering device for transport of the at least some suspended fractions away from the overflow system and back into a hopper; and - a fluid outlet downstream from the filtering device and the fractions outlet for draining water which has been filtered by the filtering device from the overflow system. - an inlet for taking in head water; - a filtering device with at least one filtering layer , fluidly coupled with the inlet so that the head water entering the inlet flows through the at least one filtering layer and the at least one filtering layer filters at least some suspended fractions from the head water by allowing head water through the filtering layer but preventing the at least some suspended fractions from flowing through with the head water; - a fractions outlet coupled with the filtering device for transport of the at least some suspended fractions away from the overflow system and back into a hopper; and - a fluid outlet downstream from the filtering device and the fractions outlet for draining water which has been filtered by the filtering device from the overflow system.
A nacelle for a turbojet engine including a cascade thrust reverser comprising a movable circular frame surrounding a cold air flow path, guided axially by longitudinal rails fastened on an intermediate casing surrounding the cold air flow path, and supporting thrust reverser cascades and movable rear cowls , this nacelle having, in a 6 o'clock position, a passage of ancillaries opening radially outwardly of the movable frame, in an area including no support structure passing radially through the cold air flow path, characterized in that the movable frame is cut in an axial plane at the passage of the ancillaries , and in that each edge of this section of the movable frame is connected to the intermediate casing by a slide rail adjusted on a longitudinal rail each disposed on one side of this passage of ancillaries .
Implement , in particular a wheel loader, having a hydraulic circuit and a lifting frame with Z-kinematics, wherein the lifting frame comprises a lifting arm pivotable about a horizontal pivot axis (A), a deflection lever pivotably coupled to the lifting arm about a horizontal pivot axis (B), which deflection lever is coupled in an articulated manner to a connecting part , and an attachment frame , on which an attachment can be reversibly mounted and that is pivotably articulated about two parallel pivot axes (C, D) to the front end of the lifting arm spaced apart from the pivot axis (A) and to the connecting part , wherein the attachment frame has a hydraulic coupling part , which can be automatically and reversibly coupled to a hydraulic coupling part on the attachment side by attaching an attachment to the attachment frame , thereby producing a hydraulic supply to the attachment , and wherein the hydraulic coupling part is connected to the hydraulic circuit via at least two hydraulic lines that are flexible at least in sections, characterised in that the hydraulic lines are attached to the deflection lever via a first suspension fastened to the deflection lever so as to be rotatable about a horizontal axis of rotation (E).