mhurhangee/patent-ind-claim-en huggingface dataset:
A method of synthesizing the N3' → P5' thiophosphoramidate oligonucleotide imetelstat of formula the method comprising a) providing a first 3'-amino protected nucleotide attached to a solid-phase support of formula (A) wherein PG is an acid-labile protecting group; b) deprotecting the protected 3'-amino group to form a free 3'-amino group; c) reacting the free 3'-amino group with a protected 3'-aminonucleoside-5'-O-cyanoethyl-N,N-diisopropylaminophosphoramidite monomer of formula (B' n ), wherein B' n with n = 2 is protected A, to form an internucleoside N3'→P5'-phosphoramidite linkage; d) sulfurization of the internucleoside phosphoramidite group using an acyl disulfide to form a N3'→P5' thiophosphoramidate; e) repeating 11 times in successive order the deprotection step b), the coupling step c) with a protected 3'-aminonucleoside-5'-O-cyanoethyl-N,N-diisopropylamino-phosphoramidite monomer of formula (B' n ) wherein the nucleoside base B' of monomer (B' n ) is protected B except when B is thymine, and wherein B n is successively nucleobase B 3 to B 13 in the respective 11 coupling steps, and the sulfurization step d); f) removing the acid-labile protecting group PG; and g) deprotecting and cleaving imetelstat from the solid-phase support; characterized in that no additional capping step is performed in any of the reaction steps a) to e). a) providing a first 3'-amino protected nucleotide attached to a solid-phase support of formula (A) wherein PG is an acid-labile protecting group; b) deprotecting the protected 3'-amino group to form a free 3'-amino group; c) reacting the free 3'-amino group with a protected 3'-aminonucleoside-5'-O-cyanoethyl-N,N-diisopropylaminophosphoramidite monomer of formula (B' n ), wherein B' n with n = 2 is protected A, to form an internucleoside N3'→P5'-phosphoramidite linkage; d) sulfurization of the internucleoside phosphoramidite group using an acyl disulfide to form a N3'→P5' thiophosphoramidate; e) repeating 11 times in successive order the deprotection step b), the coupling step c) with a protected 3'-aminonucleoside-5'-O-cyanoethyl-N,N-diisopropylamino-phosphoramidite monomer of formula (B' n ) wherein the nucleoside base B' of monomer (B' n ) is protected B except when B is thymine, and wherein B n is successively nucleobase B 3 to B 13 in the respective 11 coupling steps, and the sulfurization step d); f) removing the acid-labile protecting group PG; and g) deprotecting and cleaving imetelstat from the solid-phase support;
Commercial vehicle , comprising: a light source arranged on at least one vehicle side of the commercial vehicle , which is designed to project a controllable pattern onto a ground surface adjacent to the respective vehicle side next to the commercial vehicle ; and a control unit in signal connection with the light source , which is designed to detect an operating state of the commercial vehicle and to control the light source for signalling the detected operating state by means of the projected pattern , characterized in that the control unit is further configured to detect a road user on the ground surface of the projection and to control a change in the colour of the projected pattern upon detection of a road user on the ground surface of the projection. a light source arranged on at least one vehicle side of the commercial vehicle , which is designed to project a controllable pattern onto a ground surface adjacent to the respective vehicle side next to the commercial vehicle ; and a control unit in signal connection with the light source , which is designed to detect an operating state of the commercial vehicle and to control the light source for signalling the detected operating state by means of the projected pattern , characterized in that the control unit is further configured to detect a road user on the ground surface of the projection and to control a change in the colour of the projected pattern upon detection of a road user on the ground surface of the projection.
A double-structure bush made of a polymeric composite, comprising: a slide layer configured to receive a pin unit , in which the inner circumferential surface of the slide layer is in contact with the pin unit to support rotation of the pin unit ; and a load support layer integrally stacked on the outer circumferential surface of the slide layer , configured to be received in a boss , in which the load support layer is in contact with the inner circumferential surface of the boss to support radial load of the pin unit , characterized in that the ratio T 2 /T 1 of the thermal expansion coefficient T 2 of the load support layer to the thermal expansion coefficient T 1 of the boss in a temperature range of - 40 to 50°C is 1.5 to 3.1, and the ratio T 4 /T 3 of the thermal expansion coefficient T 4 of the slide layer to the thermal expansion coefficient T 3 of the load support layer in a temperature range of 50 to 130°C is 3.5 to 5. a slide layer configured to receive a pin unit , in which the inner circumferential surface of the slide layer is in contact with the pin unit to support rotation of the pin unit ; and a load support layer integrally stacked on the outer circumferential surface of the slide layer , configured to be received in a boss , in which the load support layer is in contact with the inner circumferential surface of the boss to support radial load of the pin unit , characterized in that the ratio T 2 /T 1 of the thermal expansion coefficient T 2 of the load support layer to the thermal expansion coefficient T 1 of the boss in a temperature range of - 40 to 50°C is 1.5 to 3.1, and the ratio T 4 /T 3 of the thermal expansion coefficient T 4 of the slide layer to the thermal expansion coefficient T 3 of the load support layer in a temperature range of 50 to 130°C is 3.5 to 5.
A method for amplifying a target nucleic acid in a biological sample obtained from a subject, wherein the biological sample comprises subject-derived cells or cell debris, the method comprising: (a) lysing the cells in the biological sample to form a lysate; (b) adding to the lysate a buffer solution comprising a buffering agent to form a reaction mixture, wherein the buffer solution has a moderately alkaline pH at ambient temperature; (c) following step (b), heating the reaction mixture to form a denatured reaction mixture; (d) adding a thermostable nucleic acid polymerase to the denatured reaction mixture; and (e) amplifying the target nucleic acid to form an amplified solution comprising an amplicon, wherein the amplifying is performed by polymerase chain reaction (PCR). (a) lysing the cells in the biological sample to form a lysate; (b) adding to the lysate a buffer solution comprising a buffering agent to form a reaction mixture, wherein the buffer solution has a moderately alkaline pH at ambient temperature; (c) following step (b), heating the reaction mixture to form a denatured reaction mixture; (d) adding a thermostable nucleic acid polymerase to the denatured reaction mixture; and (e) amplifying the target nucleic acid to form an amplified solution comprising an amplicon, wherein the amplifying is performed by polymerase chain reaction (PCR).
System for the order-dependent collection of containers at a collection location, comprising containers for products, a number of mutually parallel racks , each having, at a number of levels arranged above one another, juxtaposed storage positions for the containers, a guide system comprising horizontal longitudinal guides which extend in aisles between neighbouring racks at a number of levels parallel to the racks and horizontal transverse guides which extend transversely to the racks and adjoin the longitudinal guides , trolleys which can be displaced at different levels along the longitudinal guides and the transverse guides , each of which trolleys is provided with exchange means at least for transferring a container to a storage position and accepting a container from a storage position , a transport system for transporting containers from a trolley which is situated at an exchange location which forms part of the guide system to the collection location, in which the exchange location forms part of a row of exchange locations which are provided straight above one another at least over part of the levels , the transport system comprising a number of transfer members which are arranged straight above one another and are provided at the same levels as the exchange locations , as well as a lift for containers , in which each of the transfer members extends between an exchange location and the lift for transferring containers from an exchange location to the lift , the transport system further comprising a supply conveyor which extends between the lift and the collection location for further transporting a container from the lift to the collection location , in which the lift is provided with a carrying member which is configured to accept a container from a transfer member and to transfer the container to the supply conveyor , characterized in that each of the transfer members is configured for temporarily accommodating at least two successive containers at at least two respective transfer positions of each transfer member , and in that at least some of the exchange locations are of multiple design with a number of exchange positions, in which each exchange position extends next to a transfer position so as to be able to transfer a product container from a trolley at a transfer position to the transfer position situated next to the exchange position.
A method for updating a webpage, comprising: upon detection of an update instruction, acquiring (S10) a feature value of an update process that generates the update instruction, the feature value comprising a process name and process identification of the update process; comparing (S20) the acquired feature value with each set of feature values in a preset process whitelist; and if there is an item in the preset process whitelist which is identical to the acquired feature value, adjusting (S30) a stored webpage document according to the update instruction, wherein prior to the step of, upon detection of an update instruction, acquiring (S10) a feature value of an update process that generates the update instruction, the method further comprises: upon receipt of a security policy sent by a policy server, generating the preset process whitelist according to the security policy and a feature value of a preset process; and wherein after each time the webpage server restarts or an update process restarts, the preset process whitelist is re-generated. upon detection of an update instruction, acquiring (S10) a feature value of an update process that generates the update instruction, the feature value comprising a process name and process identification of the update process; comparing (S20) the acquired feature value with each set of feature values in a preset process whitelist; and if there is an item in the preset process whitelist which is identical to the acquired feature value, adjusting (S30) a stored webpage document according to the update instruction, wherein prior to the step of, upon detection of an update instruction, acquiring (S10) a feature value of an update process that generates the update instruction, the method further comprises: upon receipt of a security policy sent by a policy server, generating the preset process whitelist according to the security policy and a feature value of a preset process; and wherein after each time the webpage server restarts or an update process restarts, the preset process whitelist is re-generated.
Cable reel , in particular for a pipe inspection system, the cable reel having a frame and a cable receptacle , the cable receptacle being rotatably arranged on the frame, it being possible to wind a cable (K) onto the cable receptacle and unwind it from the cable receptacle, and - the cable receptacle having an inner cage and an outer cage , the diameter (d1) of the inner cage being smaller than the diameter (d2) of the outer cage, - the inner cage being arranged coaxially with respect to the outer cage and being inside the outer cage, - it being possible to rotate the inner cage and the outer cage independently of one another, - the inner cage being provided for receiving a first cable portion (K1) of the cable (K) and the outer cable being provided for receiving a second cable portion (K2) of the cable (K), and - a guide means , through which the first cable portion (K1) can be guided to the inner cage (K2) or vice versa, being provided on the outer cage , characterized in that the guide means has two rollers that are spaced apart from each other and extend parallel to the axis of rotation (DA), the first cable portion (K1) extending between the two rollers. - the cable receptacle having an inner cage and an outer cage , the diameter (d1) of the inner cage being smaller than the diameter (d2) of the outer cage, - the inner cage being arranged coaxially with respect to the outer cage and being inside the outer cage, - it being possible to rotate the inner cage and the outer cage independently of one another, - the inner cage being provided for receiving a first cable portion (K1) of the cable (K) and the outer cable being provided for receiving a second cable portion (K2) of the cable (K), and - a guide means , through which the first cable portion (K1) can be guided to the inner cage (K2) or vice versa, being provided on the outer cage ,
A torque vectoring device for a vehicle, comprising an electrical motor being connected to a differential mechanism via a transmission comprising a first planetary gear set and a second planetary gear set , wherein the torque vectoring device further comprises at least one control means for changing the torque path of the transmission between a first mode, in which the electrical motor connects only to the input shaft of the differential mechanism for hybrid drive mode, and a second mode, in which the electrical motor connects to the input shaft and to the output shaft of the differential mechanism for torque vectoring mode, wherein the electrical motor is driving the sun gear of the first planetary gear set , and wherein the input shaft of the differential mechanism is connected to the planet carrier of the first planetary gear set , wherein the first planetary gear set and the second planetary gear set are arranged coaxially with the differential mechanism , wherein the sun gear of the second planetary gear set is fixed.
A method at a user equipment, UE, for receiving multicast data in a wireless network, comprising: establishing a connection with an access point using a cellular radio access technology; configuring, with the access point, a unicast discontinuous receive cycle for receiving unicast communications from the access point; transmitting , to the access point over the connection, an internet protocol request for multicast communications; receiving control data during the unicast discontinuous receive cycle to determine a multicast discontinuous receive cycle; and receiving , from the access point and based on the internet protocol request, multicast data over resources corresponding to over-the-air multicast communications; wherein receiving the multicast data over the resources comprises receiving the multicast data in at least a portion of an ON duration of the multicast discontinuous receive cycle, wherein the multicast discontinuous receive cycle is configured by the access point to at least partially overlap the unicast discontinuous receive cycle. establishing a connection with an access point using a cellular radio access technology; configuring, with the access point, a unicast discontinuous receive cycle for receiving unicast communications from the access point; transmitting , to the access point over the connection, an internet protocol request for multicast communications; receiving control data during the unicast discontinuous receive cycle to determine a multicast discontinuous receive cycle; and receiving , from the access point and based on the internet protocol request, multicast data over resources corresponding to over-the-air multicast communications; wherein receiving the multicast data over the resources comprises receiving the multicast data in at least a portion of an ON duration of the multicast discontinuous receive cycle, wherein the multicast discontinuous receive cycle is configured by the access point to at least partially overlap the unicast discontinuous receive cycle.
Single- or multilayer, at least monoaxially oriented polyester film, characterized in that - the film comprises from 10 to 45 % by weight of crystalline silicate particles, based on the total weight of the film, - the d 50 value of the crystalline silicate particles is from 0.1 to 15 μm, determined as described above under measurement of particle diameter, - the crystalline silicate particles are cyanite and/or cristobalite and where the polymeric constituent of the film makes up at least 50 % by weight and at least 75 mol% of said constituent consists of a thermoplastic polyester. - the film comprises from 10 to 45 % by weight of crystalline silicate particles, based on the total weight of the film, - the d 50 value of the crystalline silicate particles is from 0.1 to 15 μm, determined as described above under measurement of particle diameter, - the crystalline silicate particles are cyanite and/or cristobalite
A method of controlling wireless transmissions in a wireless communication system, the method comprising: a wireless communication device (10, 11; 800; 900) configuring a wireless channel defining multiple resource units by orthogonal frequency division multiplexing, OFDM, on a plurality of subcarriers; the wireless communication device (10, 11; 800; 900) sending a first wireless transmission on a first subset of the multiple resource units; and while sending the first wireless transmission, the wireless communication device (10, 11; 800; 900) receiving a second wireless transmission on a second subset of the multiple resource units, the second wireless transmission starting before the first wireless transmission, wherein the first subset of the multiple resource units and the second subset of the multiple resource units are at least in part non-overlapping, wherein OFDM symbols of the second wireless transmission are time-aligned with OFDM symbols of the first wireless transmission, wherein the first wireless transmission and the second wireless transmission each comprise a preamble part and a data part, and wherein the preamble part of the first wireless transmission is punctured based on the second subset of the multiple resource units. a wireless communication device (10, 11; 800; 900) configuring a wireless channel defining multiple resource units by orthogonal frequency division multiplexing, OFDM, on a plurality of subcarriers; the wireless communication device (10, 11; 800; 900) sending a first wireless transmission on a first subset of the multiple resource units; and while sending the first wireless transmission, the wireless communication device (10, 11; 800; 900) receiving a second wireless transmission on a second subset of the multiple resource units, the second wireless transmission starting before the first wireless transmission, wherein the first subset of the multiple resource units and the second subset of the multiple resource units are at least in part non-overlapping, wherein OFDM symbols of the second wireless transmission are time-aligned with OFDM symbols of the first wireless transmission, wherein the first wireless transmission and the second wireless transmission each comprise a preamble part and a data part, and wherein the preamble part of the first wireless transmission is punctured based on the second subset of the multiple resource units.
An optical module comprising: a plurality of laser diodes arranged on the same plane; and a plurality of mirrors that reflect each light emitted from each of the laser diodes , a condenser lens into which the light reflected by the plurality of mirrors is entered, wherein the plurality of mirrors reflects each light emitted from each of the laser diodes in a direction inclined with respect to the plane and aligns the light in a fast axis direction, wherein the fast axis direction is defined as the direction orthogonal to the plane on which the plurality of laser diodes is arranged, characterized in that each light emitted from each of the laser diodes is reflected by the plurality of mirrors in such a manner as to be away from one another in the fast axis direction such that the entrance angle of the light entered at positions separated from the outer peripheral side of the condenser lens , that is, separated from the optical axis of the condenser lens is increased when compared to lights reflected by the plurality of mirrors propagating in directions parallel to one another, and is condensed at one point by the condenser lens . a plurality of laser diodes arranged on the same plane; and a plurality of mirrors that reflect each light emitted from each of the laser diodes , a condenser lens into which the light reflected by the plurality of mirrors is entered, wherein the plurality of mirrors reflects each light emitted from each of the laser diodes in a direction inclined with respect to the plane and aligns the light in a fast axis direction, wherein the fast axis direction is defined as the direction orthogonal to the plane on which the plurality of laser diodes is arranged, characterized in that each light emitted from each of the laser diodes is reflected by the plurality of mirrors in such a manner as to be away from one another in the fast axis direction such that the entrance angle of the light entered at positions separated from the outer peripheral side of the condenser lens , that is, separated from the optical axis of the condenser lens is increased when compared to lights reflected by the plurality of mirrors propagating in directions parallel to one another, and is condensed at one point by the condenser lens .
A measuring device for being mounted in a mobile object, for example, a vehicle, comprising: an irradiator that irradiates an electromagnetic wave; a movable reflection unit that reflects the electromagnetic wave; a control unit that moves the electromagnetic wave along a first direction (H) by controlling the irradiator and the movable reflection unit; and a sensor that is able to receive the electromagnetic wave, wherein the sensor is disposed at a position through which the electromagnetic wave passes when the electromagnetic wave is moved in the first direction, and wherein the control unit sets a movement range of the movable reflection unit using a first detection value that is a detection value of the sensor when the electromagnetic wave is irradiated at a first position (Sa) ahead of the sensor in the first direction and a second detection value that is a detection value of the sensor when the electromagnetic wave is irradiated at a second position (Sb) behind the sensor in the first direction. an irradiator that irradiates an electromagnetic wave; a movable reflection unit that reflects the electromagnetic wave; a control unit that moves the electromagnetic wave along a first direction (H) by controlling the irradiator and the movable reflection unit; and a sensor that is able to receive the electromagnetic wave, wherein the sensor is disposed at a position through which the electromagnetic wave passes when the electromagnetic wave is moved in the first direction, and wherein the control unit sets a movement range of the movable reflection unit using a first detection value that is a detection value of the sensor when the electromagnetic wave is irradiated at a first position (Sa) ahead of the sensor in the first direction and a second detection value that is a detection value of the sensor when the electromagnetic wave is irradiated at a second position (Sb) behind the sensor in the first direction.