mhurhangee/patent-ind-claim-en huggingface dataset:
An inhibitor of miR-181 for use in the treatment and/or prevention of a mitochondrial disorder selected from the group consisting of: Leigh syndrome, Leber Hereditary optic Neuropathy (LHON), Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis and Stroke Syndrome (MELAS), Myoclonic Epilepsy associated with Ragged-Red fibers (MERRF), Progressive External Ophthalmoplegia (PEO), Pearson's syndrome, Maternally inherited Myopathy and cardiomyopathy (MIMyCA), Kjer's optic neuropathy, Neuropathy ataxia and retinitis pigmentosa (NARP), Autosomal dominant optic atrophy, Kearns-Sayre syndrome, Friedreich's ataxia, Hereditary Spastic paraplegia, Charcot-Marie-Tooth disease, sporadic age-related neurodegenerative disease, Parkinson's Disease (PD), Alzheimer's Disease (AD), Age-related Macular degeneration (AMD), Diabetic Retinopathy, Glaucoma, familiar neurodegenerative disease, familiar PD, familiar AD, Huntington's disease, Retinitis Pigmentosa (RP), and Stargardt's disease, said inhibitor being an inhibitory nucleic acid agent comprising at least one sequence complementary to miR-181 wherein said inhibitor comprises a sequence complementary to ACAUUCA (SEQ ID NO. 5).
A power supply and demand prediction system that is configured to predict supply and demand of power of a utility customer group (G) that includes multiple utility customers , the power supply and demand prediction system comprises: an individual stored power acquisition unit configured to acquire an amount of stored power of each of multiple batteries belonging to the utility customer group (G); an individual demand prediction unit configured to predict an amount of demand for power for each utility customer ; an individual power generation prediction unit configured to predict an amount of generated power of each of multiple power generation devices belonging to the utility customer group (G); and an individual stored power prediction unit configured to predict an amount of stored power of each battery on the basis of the amount of stored power acquired for each battery, the amount of demand predicted for each utility customer , and the amount of generated power predicted for each power generation device; characertized by a request target selection unit configured to select the utility customer for whom an amount of suppliable power predicted on the basis of the amount of stored power predicted for each battery and/or the amount of generated power predicted for each power generation device is not less than a predetermined threshold, as a target of a demand response request. an individual stored power acquisition unit configured to acquire an amount of stored power of each of multiple batteries belonging to the utility customer group (G); an individual demand prediction unit configured to predict an amount of demand for power for each utility customer ; an individual power generation prediction unit configured to predict an amount of generated power of each of multiple power generation devices belonging to the utility customer group (G); and an individual stored power prediction unit configured to predict an amount of stored power of each battery on the basis of the amount of stored power acquired for each battery, the amount of demand predicted for each utility customer , and the amount of generated power predicted for each power generation device; characertized by a request target selection unit configured to select the utility customer for whom an amount of suppliable power predicted on the basis of the amount of stored power predicted for each battery and/or the amount of generated power predicted for each power generation device is not less than a predetermined threshold, as a target of a demand response request.
A compressor , comprising: a cylinder ; a piston configured to be reciprocable in the cylinder; a suction space (Si) capable of communicating with a working chamber (Sc) formed by the cylinder and the piston; a compressor casing for housing the cylinder and the piston , a discharge space (Sv) capable of communicating with the working chamber; a suction valve for switching a state of communication between the suction space (Si) and the working chamber (Sc); a discharge valve for switching a state of communication between the discharge space and the working chamber; a partition wall portion disposed so as to surround the working chamber, and separating the suction space and the discharge space, a valve plate holding the suction valve and the discharge valve, the valve plate serving as the partition wall portion ; and a head cover provided above the partition wall portion , wherein the compressor casing is configured to include the suction space (Si), and the head cover is configured to form the discharge space (Sv) together with the valve plate , the compressor being characterized in that the compressor comprises a cooling medium path formed in the valve plate as the partition wall portion which separates the suction space of the compressor casing and the discharge space formed by the head cover and the valve plate. a cylinder ; a piston configured to be reciprocable in the cylinder; a suction space (Si) capable of communicating with a working chamber (Sc) formed by the cylinder and the piston; a compressor casing for housing the cylinder and the piston , a discharge space (Sv) capable of communicating with the working chamber; a suction valve for switching a state of communication between the suction space (Si) and the working chamber (Sc); a discharge valve for switching a state of communication between the discharge space and the working chamber; a partition wall portion disposed so as to surround the working chamber, and separating the suction space and the discharge space, a valve plate holding the suction valve and the discharge valve, the valve plate serving as the partition wall portion ; and a head cover provided above the partition wall portion , wherein the compressor casing is configured to include the suction space (Si), and the head cover is configured to form the discharge space (Sv) together with the valve plate , the compressor being characterized in that the compressor comprises a cooling medium path formed in the valve plate as the partition wall portion which separates the suction space of the compressor casing and the discharge space formed by the head cover and the valve plate.
A method of over-the-air beamforming calibration for a multi-antenna transceiver having a first plurality of antenna elements connected to respective transceiver chains, wherein beamforming calibration comprises determining respective beamforming calibration factors for the transceiver chains of the antenna elements of the first plurality, the method comprising: determining a second plurality of measurement resources for calibration sounding, wherein the second plurality is smaller than the first plurality; for each measurement resource of the second plurality, selecting one or more antenna elements of the first plurality for sounding signal transmission, wherein each antenna element of the first plurality is selected for one or more of the measurement resources of the second plurality; and using each measurement resource of the second plurality, overlappingly transmitting respective sounding signals by the selected one or more antenna elements, characterized in that - when two or more antenna elements are selected for overlapping sounding signal transmission using a measurement resource - the selection comprises selecting antenna elements having a mutual coupling that exceeds a mutual coupling threshold. determining a second plurality of measurement resources for calibration sounding, wherein the second plurality is smaller than the first plurality; for each measurement resource of the second plurality, selecting one or more antenna elements of the first plurality for sounding signal transmission, wherein each antenna element of the first plurality is selected for one or more of the measurement resources of the second plurality; and using each measurement resource of the second plurality, overlappingly transmitting respective sounding signals by the selected one or more antenna elements, characterized in that - when two or more antenna elements are selected for overlapping sounding signal transmission using a measurement resource - the selection comprises selecting antenna elements having a mutual coupling that exceeds a mutual coupling threshold.
A system for coupling a suspended boom frame to a fixed frame , the system comprising: a fixed frame operably, fixedly engaged to a sprayer vehicle, the fixed frame comprising one or more controllable springs , the fixed frame comprising a fixed coupling providing a pivot point; a suspended frame operably coupled with a pair of boom wings to form a suspended portion, the suspended frame comprising: a suspended coupling disposed above a center of gravity of the suspended portion, the suspended coupling providing for pivoting about the fixed coupling in roll, yaw, and pitch axes; and one or more dampers operably, pivotably coupled with the fixed frame to dampen movement of the suspended frame in the roll axis; wherein the one or more controllable springs engage with the suspended frame to control a position of the suspended frame with respect to the fixed frame , characterized in that the suspended coupling is disposed greater than or equal to halfway from the center of gravity of the suspended portion to a top of the suspended frame . a fixed frame operably, fixedly engaged to a sprayer vehicle, the fixed frame comprising one or more controllable springs , the fixed frame comprising a fixed coupling providing a pivot point; a suspended frame operably coupled with a pair of boom wings to form a suspended portion, the suspended frame comprising: a suspended coupling disposed above a center of gravity of the suspended portion, the suspended coupling providing for pivoting about the fixed coupling in roll, yaw, and pitch axes; and one or more dampers operably, pivotably coupled with the fixed frame to dampen movement of the suspended frame in the roll axis; a suspended coupling disposed above a center of gravity of the suspended portion, the suspended coupling providing for pivoting about the fixed coupling in roll, yaw, and pitch axes; and one or more dampers operably, pivotably coupled with the fixed frame to dampen movement of the suspended frame in the roll axis; wherein the one or more controllable springs engage with the suspended frame to control a position of the suspended frame with respect to the fixed frame , characterized in that the suspended coupling is disposed greater than or equal to halfway from the center of gravity of the suspended portion to a top of the suspended frame .
A software-defined radio chip comprising: a digital front end arranged to convert digital intermediate frequency samples to digital baseband samples; and a digital back end arranged to process the digital baseband samples to provide a consumable content; the software-defined radio chip further comprising a reconfigurable hardware programmable logic circuit configured at least to function as the digital front end; characterised in that the reconfigurable hardware programmable logic circuit comprises a secure cryptographic device arranged to provide a root of trust having a particular key as part of a key ladder scheme. a digital front end arranged to convert digital intermediate frequency samples to digital baseband samples; and a digital back end arranged to process the digital baseband samples to provide a consumable content; the software-defined radio chip further comprising a reconfigurable hardware programmable logic circuit configured at least to function as the digital front end; characterised in that the reconfigurable hardware programmable logic circuit comprises a secure cryptographic device arranged to provide a root of trust having a particular key as part of a key ladder scheme.
A composition for inactivating a retrovirus in a mammalian cell comprising an expression vector encoding a) a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease; and b) two or more guide RNAs, wherein (i) a first guide RNA (gRNA) targets a first cleavage site and is complementary to a first target nucleic acid sequence within a 5' long terminal repeat (LTR) of a retrovirus, and (ii) a second guide RNA (gRNA) targets a second cleavage site and is complementary to a second target nucleic acid sequence within a 3' long terminal repeat (LTR) of the retrovirus, and wherein at least two encoded guide RNAs are different, thereby resulting, when administered to a mammalian cell comprising the retrovirus, in excision of the retroviral sequence between the cleavage sites recognized by the CRISPR associated endonuclease, and thereby inactivating the retrovirus in the mammalian cell, wherein the gRNAs target sequences that minimize off-target effects in the mammalian cell, wherein the retrovirus is HIV, wherein the gRNAs comprise crRNA and tracrRNA, and wherein the first target nucleic acid sequence or the second target nucleic acid sequence comprises a sequence having 95% identity to a sequence selected from the group consisting of SEQ ID NO: 96 (LTR A), SEQ ID NO: 121 (LTR B), SEQ ID NO: 87 (LTR C), and SEQ ID NO: 110 (LTR D) or a combination thereof. a) a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease; and b) two or more guide RNAs, wherein (i) a first guide RNA (gRNA) targets a first cleavage site and is complementary to a first target nucleic acid sequence within a 5' long terminal repeat (LTR) of a retrovirus, and (ii) a second guide RNA (gRNA) targets a second cleavage site and is complementary to a second target nucleic acid sequence within a 3' long terminal repeat (LTR) of the retrovirus, and wherein at least two encoded guide RNAs are different, thereby resulting, when administered to a mammalian cell comprising the retrovirus, in excision of the retroviral sequence between the cleavage sites recognized by the CRISPR associated endonuclease, and thereby inactivating the retrovirus in the mammalian cell,
A wheel assembly of a mobile robot , comprising: a wheel gear box assembly which includes a main wheel to move a mobile robot , a driving motor and a gear which rotate the main wheel and generates a hinge torque to a first hinge axis equipped at one side by the rotation of the main wheel to be rotatable within a predetermined range; characterized in that , a hinge shaft which has one side end coupled to the first hinge axis of the wheel gear box assembly and rotates the wheel gear box assembly by means of a second hinge axis equipped at the other side end; and a wheel upper cover which is coupled to the wheel gear box assembly to protect an upper portion and includes a second hinge axis mounting unit formed at the other side end to be coupled to the second hinge axis . a wheel gear box assembly which includes a main wheel to move a mobile robot , a driving motor and a gear which rotate the main wheel and generates a hinge torque to a first hinge axis equipped at one side by the rotation of the main wheel to be rotatable within a predetermined range; characterized in that , a hinge shaft which has one side end coupled to the first hinge axis of the wheel gear box assembly and rotates the wheel gear box assembly by means of a second hinge axis equipped at the other side end; and a wheel upper cover which is coupled to the wheel gear box assembly to protect an upper portion and includes a second hinge axis mounting unit formed at the other side end to be coupled to the second hinge axis .
Transdermal therapeutic system for the transdermal administration of asenapine comprising a self-adhesive layer structure containing a therapeutically effective amount of asenapine, said self-adhesive layer structure comprising: A) a backing layer; B) an asenapine-containing matrix layer consisting of a matrix layer composition comprising: 1. asenapine; and 2. a polymer selected from acrylic polymers; wherein the transdermal therapeutic system has an area of release of from 5 to 100 cm 2 and contains at least 0.70 mg/cm 2 asenapine. A) a backing layer; B) an asenapine-containing matrix layer consisting of a matrix layer composition comprising: 1. asenapine; and 2. a polymer selected from acrylic polymers; 1. asenapine; and 2. a polymer selected from acrylic polymers;
Painting installation for painting workpieces , comprising: - a painting booth , in which the workpieces are paintable with paint; - a conveying device , by means of which the workpieces to be painted are conveyable in a conveying direction through the painting booth ; - a separation and/or filter system for cleaning a raw gas flow, which is leaving the painting booth and has absorbed paint overspray in the painting booth , wherein the separation and/or filter system comprises at least two filter devices for separating the paint overspray from the raw gas flow and at least two clean gas lines for clean gas flows, which are obtainable by cleaning the raw gas flow by means of the at least two filter devices , wherein the separation and/or filer system comprises at least one raw gas shaft , which is arranged substantially centrally below the painting booth with respect to a horizontal direction running perpendicular to the conveying direction , wherein the separation and/or filter system comprises at least one clean gas collecting channel , into which the at least two clean gas lines of the separation and/or filter system open, wherein the at least one clean gas collecting channel , on the one hand, and the at least two filter devices , on the other hand, are arranged on mutually opposing sides of the separation and/or filter system with respect to a vertical longitudinal centre plane of the painting booth , wherein one of the at least two clean gas lines , which open into the clean gas collecting channel , crosses and/or traverses the raw gas shaft , wherein raw gas preferably flows around the clean gas line during an operation of the painting installation . - a painting booth , in which the workpieces are paintable with paint; - a conveying device , by means of which the workpieces to be painted are conveyable in a conveying direction through the painting booth ; - a separation and/or filter system for cleaning a raw gas flow, which is leaving the painting booth and has absorbed paint overspray in the painting booth , wherein the separation and/or filter system comprises at least two filter devices for separating the paint overspray from the raw gas flow and at least two clean gas lines for clean gas flows, which are obtainable by cleaning the raw gas flow by means of the at least two filter devices ,
An ultrasonic transducer multilayer structure , comprising : - a semiconductor layer stack defining a diode , - a micro-machined ultrasonic transducer, MUT, layer stack being electrically in series with said diode and disposed at least partly on said semiconductor layer stack, characterized in said MUT layer stack comprising an electrically conductive layer sandwiched between said semiconductor layer stack and the MUT layer stack to provide electrical contact with said diode and the MUT layer stack, - a cavity (C1,C2,C3,107) extending over a region (R1,R2,R3,R4) comprising at least a portion of said semiconductor layer stack and said electrically conductive layer, wherein said MUT layer stack comprises a membrane extending at least partly over said region. - a semiconductor layer stack defining a diode , - a micro-machined ultrasonic transducer, MUT, layer stack being electrically in series with said diode and disposed at least partly on said semiconductor layer stack, characterized in said MUT layer stack comprising an electrically conductive layer sandwiched between said semiconductor layer stack and the MUT layer stack to provide electrical contact with said diode and the MUT layer stack, - a cavity (C1,C2,C3,107) extending over a region (R1,R2,R3,R4) comprising at least a portion of said semiconductor layer stack and said electrically conductive layer,
A level comprising: a frame comprising: a first planar base surface ; a top surface opposing the base surface ; a longitudinal axis ; a fixed end at a first end of the longitudinal axis ; an open end opposing the fixed end; and an orientation measuring component ; a slidable body member coupled to the frame that extends and retracts along the longitudinal axis of the frame , the slidable body member comprising: a second planar base surface generally coplanar with the first planar base surface ; an enclosed end ; and an adjustable end opposing the enclosed end , the adjustable end extending past the open end of the frame when the slidable body member is fully extended; characterized in : a first bushing that couples the slidable body member and the frame , the first bushing fixedly coupled to one of the frame or the slidable body member ; and a second bushing that couples the slidable body member and the frame , the second bushing fixedly coupled to one of the frame or the slidable body member . a frame comprising: a first planar base surface ; a top surface opposing the base surface ; a longitudinal axis ; a fixed end at a first end of the longitudinal axis ; an open end opposing the fixed end; and an orientation measuring component ; a first planar base surface ; a top surface opposing the base surface ; a longitudinal axis ; a fixed end at a first end of the longitudinal axis ; an open end opposing the fixed end; and an orientation measuring component ; a slidable body member coupled to the frame that extends and retracts along the longitudinal axis of the frame , the slidable body member comprising: a second planar base surface generally coplanar with the first planar base surface ; an enclosed end ; and an adjustable end opposing the enclosed end , the adjustable end extending past the open end of the frame when the slidable body member is fully extended; a second planar base surface generally coplanar with the first planar base surface ; an enclosed end ; and an adjustable end opposing the enclosed end , the adjustable end extending past the open end of the frame when the slidable body member is fully extended; a first bushing that couples the slidable body member and the frame , the first bushing fixedly coupled to one of the frame or the slidable body member ; and a second bushing that couples the slidable body member and the frame , the second bushing fixedly coupled to one of the frame or the slidable body member .