A method of prenatal diagnostics comprising the steps of: a) contacting cells comprised in a blood sample obtained from a woman carrying a fetus with at least one magnetic labelling agent directed against a fetal trophoblast marker, b) enriching said sample for fetal trophoblasts with magnetic activated cell sorting (MACS), c) following the enrichment step, the single cell sorting by FACS is performed by contacting the enriched cells with at least one fluorescent labelling agent selected from each of the groups: i. fluorescent labelling agent directed against the nucleus, ii. fluorescent labelling agent directed against a maternal cell marker, and iii. fluorescent labelling agent directed against a fetal trophoblast marker d) single cell sorting the fluorescently labelled cells on a fluorescence activated cell sorter (FACS) from said enriched sample based on: i. positive selection of said fluorescent labelling agent directed against a fetal trophoblast marker, ii. positive selection of said fluorescent labelling agent directed against the nucleus, and iii. negative selection of said fluorescent labelling agent directed against a maternal cell marker e) identifying fetal trophoblasts among said sorted cells, comprising a step of assigning a fetal origin classifier to individually sorted cells by obtaining a genotype from the single sorted cells, and f) diagnosing the phenotype of the fetus. a) contacting cells comprised in a blood sample obtained from a woman carrying a fetus with at least one magnetic labelling agent directed against a fetal trophoblast marker, b) enriching said sample for fetal trophoblasts with magnetic activated cell sorting (MACS), c) following the enrichment step, the single cell sorting by FACS is performed by contacting the enriched cells with at least one fluorescent labelling agent selected from each of the groups: i. fluorescent labelling agent directed against the nucleus, ii. fluorescent labelling agent directed against a maternal cell marker, and iii. fluorescent labelling agent directed against a fetal trophoblast marker i. fluorescent labelling agent directed against the nucleus, ii. fluorescent labelling agent directed against a maternal cell marker, and iii. fluorescent labelling agent directed against a fetal trophoblast marker d) single cell sorting the fluorescently labelled cells on a fluorescence activated cell sorter (FACS) from said enriched sample based on: i. positive selection of said fluorescent labelling agent directed against a fetal trophoblast marker, ii. positive selection of said fluorescent labelling agent directed against the nucleus, and iii. negative selection of said fluorescent labelling agent directed against a maternal cell marker i. positive selection of said fluorescent labelling agent directed against a fetal trophoblast marker, ii. positive selection of said fluorescent labelling agent directed against the nucleus, and iii. negative selection of said fluorescent labelling agent directed against a maternal cell marker e) identifying fetal trophoblasts among said sorted cells, comprising a step of assigning a fetal origin classifier to individually sorted cells by obtaining a genotype from the single sorted cells, and f) diagnosing the phenotype of the fetus. <EOS>