mhurhangee/patent-ind-claim-en huggingface dataset:
A method of choosing an optimal clamp torque for fastening a flexible workpiece to be cut, for example by a face milling process, featured by that in a first step, the workpiece is fastened to a machine tool's table with the use of fastening screws under a first steady screws' tightening torque, then the workpiece is excited with the use of a favourably modal hammer, and frequency is measured and vibration amplitude spectrum is registered, and next the cost function corresponding to the work of cutting forces in the direction of cutting layer width, is determined using following formula L = ∑ α = 1 i α b D f α 2 πn 30 n 60 2 − f α 2 sin 2 πn 60 f α where: α - amplitude spectrum peak number, i α - number of the identified amplitude spectrum peaks, b D - nominal cutting layer width, in mm f α - frequency of amplitude spectrum peak no. α , in Hz n - spindle speed in rev/min after that, in a second step, the second screw tightening torque is set down and in such defined conditions of clamping it is done as in the first step, and next the respective steps are repeated for a finite number of screws tightening torques, whereas the required clamp torque is selected for which a value of the work of cutting forces in the direction of cutting layer width, in the other words the cost function L, is minimal. α - amplitude spectrum peak number, i α - number of the identified amplitude spectrum peaks, b D - nominal cutting layer width, in mm f α - frequency of amplitude spectrum peak no. α , in Hz n - spindle speed in rev/min after that, in a second step, the second screw tightening torque is set down and in such defined conditions of clamping it is done as in the first step, and next the respective steps are repeated for a finite number of screws tightening torques, whereas the required clamp torque is selected for which a value of the work of cutting forces in the direction of cutting layer width, in the other words the cost function L, is minimal.
A method for the specific separation of target cells from a biological sample, comprising the steps of: (a) providing a phase-change hydrogel composition, the hydrogel being labeled with biological moieties that are capable of specifically interacting with one or more marker(s) on the target cells; (b) incubating the biological sample with said hydrogel composition under conditions allowing polymerization of the hydrogel and binding of the target cells to the hydrogel via said biological moieties, thus forming cell-hydrogel complexes; (c) separating said cell-hydrogel complexes from unbound cells and other components of the biological sample in a centrifugation vessel via their sedimentation velocity in a counter-current centrifuge; (d) depolymerizing the hydrogel once the cell-hydrogel complexes are separated by applying suitable conditions within the centrifugation vessel in the counter-current centrifuge; (e) removing the depolymerized hydrogel composition from the centrifugation vessel in the counter-current centrifuge; and (f) transferring the separated target cells into a collection vessel, wherein the target cells are immune cells, selected from the group consisting of T cells, NK cells, tumor infiltrating cells (TILs), and immune cells having cell-killing activity. (a) providing a phase-change hydrogel composition, the hydrogel being labeled with biological moieties that are capable of specifically interacting with one or more marker(s) on the target cells; (b) incubating the biological sample with said hydrogel composition under conditions allowing polymerization of the hydrogel and binding of the target cells to the hydrogel via said biological moieties, thus forming cell-hydrogel complexes; (c) separating said cell-hydrogel complexes from unbound cells and other components of the biological sample in a centrifugation vessel via their sedimentation velocity in a counter-current centrifuge; (d) depolymerizing the hydrogel once the cell-hydrogel complexes are separated by applying suitable conditions within the centrifugation vessel in the counter-current centrifuge; (e) removing the depolymerized hydrogel composition from the centrifugation vessel in the counter-current centrifuge; and (f) transferring the separated target cells into a collection vessel,
Pre-chamber spark plug having a housing which has at the front end thereof a pre-chamber having an ignition electrode which is arranged therein, wherein the ignition electrode comprises a base and electrode pins which protrude from the base, wherein the ignition electrode is formed from a metal sheet which comprises an iridium alloy and the pins in order to form a basket shape are bent from the plane of the base , wherein the ignition electrode, in particular the electrode pins, is/are separated from the metal sheet by means of laser-cutting, characterised in that the electrode pins have a thickness in the range from 0.2 mm to 0.5 mm and a width in the range from 0.3 mm to 0.6 mm, from which a ratio of thickness/width in the range from 0.33 to 1.67 with a preferred range from 0.4 (slightly rectangular) to 1.0 (square) is produced.
A device-to-device, D2D, service transmission method, comprising: obtaining , by user equipment, UE, signal quality of a first cell of a base station operating on a first transmission carrier frequency; receiving , by the UE, first indication information related to the first cell, wherein the first indication information is used to indicate that the base station can control the UE to transmit device-to-device, D2D, service data on a second transmission carrier frequency in the first cell, and the first transmission carrier frequency and the second transmission carrier frequency are located at different frequencies; when the UE determines that the signal quality of the first cell is higher than a preset threshold, and the first indication information related to the first cell is received, selecting, by the UE, the first cell as a serving cell; and transmitting , by the UE, the D2D service data on the second transmission carrier frequency. obtaining , by user equipment, UE, signal quality of a first cell of a base station operating on a first transmission carrier frequency; receiving , by the UE, first indication information related to the first cell, wherein the first indication information is used to indicate that the base station can control the UE to transmit device-to-device, D2D, service data on a second transmission carrier frequency in the first cell, and the first transmission carrier frequency and the second transmission carrier frequency are located at different frequencies; when the UE determines that the signal quality of the first cell is higher than a preset threshold, and the first indication information related to the first cell is received, selecting, by the UE, the first cell as a serving cell; and transmitting , by the UE, the D2D service data on the second transmission carrier frequency.
Apparatus for the treatment of air, comprising a housing which has an air inlet and an air outlet , is connected to a fan and comprises at least one nozzle connected to a pressure line for water and a deflector body lying opposite the nozzle at a spaced interval and forming a deflector plate , characterised in that the deflector plate has a structured deflector surface and in that the nozzle is designed as a swirl nozzle which is arranged in a positionally fixed manner with respect to the deflector plate in order to generate a water jet cone rotating about the nozzle axis.
A method of sealing a well penetrating a formation and in fluid communication therewith through perforations in a tubular with a sealant at a desired location in the well, comprising: selecting a preexisting fluid pathway extending between a production platform and a desired sealing location in the well to be sealed with the sealant; determining, for the well to be sealed, a desired quantity of sealant having known flow qualities, to be delivered in fluid form to the sealing location of the well; determining, based on the flow qualities of the sealant in fluid form and the flow qualities of the preexisting fluid pathway, a time needed to deliver the desired quantity of the sealant in fluid form to the sealing location in the well; determining, based on the time required to deliver the desired quantity of the sealant in fluid form to the sealing location in the well, whether the sealant will maintain the fluid form until it reaches the sealing location using the preexisting fluid pathway; if necessary, changing one or more qualities of the sealant to a modified desired sealant composition so that the desired quantity of the modified sealant will reach the sealing location in the well while in the fluid form; and transporting one of the desired quantity of sealant or the modified sealant, in fluid form, through the preexisting fluid pathway between the production platform and the desired sealing location in the well to be sealed. selecting a preexisting fluid pathway extending between a production platform and a desired sealing location in the well to be sealed with the sealant; determining, for the well to be sealed, a desired quantity of sealant having known flow qualities, to be delivered in fluid form to the sealing location of the well; determining, based on the flow qualities of the sealant in fluid form and the flow qualities of the preexisting fluid pathway, a time needed to deliver the desired quantity of the sealant in fluid form to the sealing location in the well; determining, based on the time required to deliver the desired quantity of the sealant in fluid form to the sealing location in the well, whether the sealant will maintain the fluid form until it reaches the sealing location using the preexisting fluid pathway; if necessary, changing one or more qualities of the sealant to a modified desired sealant composition so that the desired quantity of the modified sealant will reach the sealing location in the well while in the fluid form; and transporting one of the desired quantity of sealant or the modified sealant, in fluid form, through the preexisting fluid pathway between the production platform and the desired sealing location in the well to be sealed.
A composition for preserving food products, comprising: (i) from 85% to 97% by weight on the total weight of the composition of one or more aliphatic diols or esters thereof selected from the group consisting of: 1,3 diols and a mixture of 1,3 diols and 1,2 diols; and (ii) from 3% to 15% by weight on the total weight of the composition of one or more compounds selected from the group consisting of: monohydric aromatic alcohols, terpenes, terpenoids, guaiacols, phenols, diphenols, coumarins, anthraquinones, flavones, flavonoids, phenolic acids and derivatives thereof, hydroxycinnamic acids and derivatives thereof, and mixtures thereof. (i) from 85% to 97% by weight on the total weight of the composition of one or more aliphatic diols or esters thereof selected from the group consisting of: 1,3 diols and a mixture of 1,3 diols and 1,2 diols; and (ii) from 3% to 15% by weight on the total weight of the composition of one or more compounds selected from the group consisting of: monohydric aromatic alcohols, terpenes, terpenoids, guaiacols, phenols, diphenols, coumarins, anthraquinones, flavones, flavonoids, phenolic acids and derivatives thereof, hydroxycinnamic acids and derivatives thereof, and mixtures thereof.
Refrigerator and/or freezer with a cooling air circuit for cooling the interior of the appliance or at least one compartment of the appliance, and with an ice maker, wherein the appliance comprises at least one fan associated to the ice maker which is arranged in such a way that cold air is supplied to the ice maker by means of the fan, wherein the fan associated to the ice maker is formed separately from a fan associated to the cooling air circuit and is associated directly to the ice maker, characterized in that the fan associated to the ice maker is configured such that its operating condition is independent of the operating condition of the refrigerator and/or freezer, and the appliance has no separate air duct associated to the ice maker, and means are provided, by means of which the filling level in the ice maker or in an ice container can be detected, and the rotational speed and/or the relative switch-on period of the fan associated to the ice maker depends on the filling level measured.
Method for controlling a tail lift which has a loading platform , wherein the loading platform can be both pivoted and also lowered or raised by means of at least one drive, and the tail lift is controlled in a manner dependent on an electrical voltage of the at least one drive, which electrical voltage is measured during the operation of the tail lift , characterized in that the tail lift is operated in a manner dependent on a specifiable relative deviation between an actual gradient of the voltage profile with respect to time and a setpoint gradient of the voltage profile with respect to time.
A conjugate comprising an isolated antigen-binding protein which binds claudin-6 or antigen-binding fragment thereof, a cytotoxic agent or a chemotherapeutic agent and a linker, wherein the antigen-binding protein is selected from: (a) an antigen-binding protein comprising: (i) an HC CDR1 comprising the amino acid sequence of FTFSXYX (SEQ ID NO: 455), wherein X at position 5 is N and X at position 7 is W; (ii) an HC CDR2 comprising the amino acid sequence of IRLKXDXYAT (SEQ ID NO: 456), wherein X at position 5 is S and X at position 7 is N; (iii) an HC CDR3 comprising the amino acid sequence of XDGPPSGX (SEQ ID NO: 457), wherein X at position 1 is N and X at position 8 is S; (iv) an LC CDR1 comprising the amino acid sequence of EXIYSY (SEQ ID NO: 476), wherein X is N; (v) an LC CDR2 comprising the amino acid sequence of XAK (SEQ ID NO: 477), wherein X at position 1 is N; and (vi) an LC CDR3 comprising the amino acid sequence of QXHYXVPWT (SEQ ID NO: 454), wherein X at position 2 is H and X at position 5 is T; and (b) an antigen-binding protein comprising the heavy chain (HC) CDR1-3 amino acid sequences of SEQ ID NOs: 23, 24, and 25, and the light chain (LC) CDR1-3 amino acid sequences of SEQ ID NOs: 20, 21, and 22, wherein the linker is between the antibody and the cytotoxic agent or chemotherapeutic agent and the linker is selected from the group consisting of VC-PAB, GGFG and CL2A. (a) an antigen-binding protein comprising: (i) an HC CDR1 comprising the amino acid sequence of FTFSXYX (SEQ ID NO: 455), wherein X at position 5 is N and X at position 7 is W; (ii) an HC CDR2 comprising the amino acid sequence of IRLKXDXYAT (SEQ ID NO: 456), wherein X at position 5 is S and X at position 7 is N; (iii) an HC CDR3 comprising the amino acid sequence of XDGPPSGX (SEQ ID NO: 457), wherein X at position 1 is N and X at position 8 is S; (iv) an LC CDR1 comprising the amino acid sequence of EXIYSY (SEQ ID NO: 476), wherein X is N; (v) an LC CDR2 comprising the amino acid sequence of XAK (SEQ ID NO: 477), wherein X at position 1 is N; and (vi) an LC CDR3 comprising the amino acid sequence of QXHYXVPWT (SEQ ID NO: 454), wherein X at position 2 is H and X at position 5 is T; and (i) an HC CDR1 comprising the amino acid sequence of FTFSXYX (SEQ ID NO: 455), wherein X at position 5 is N and X at position 7 is W; (ii) an HC CDR2 comprising the amino acid sequence of IRLKXDXYAT (SEQ ID NO: 456), wherein X at position 5 is S and X at position 7 is N; (iii) an HC CDR3 comprising the amino acid sequence of XDGPPSGX (SEQ ID NO: 457), wherein X at position 1 is N and X at position 8 is S; (iv) an LC CDR1 comprising the amino acid sequence of EXIYSY (SEQ ID NO: 476), wherein X is N; (v) an LC CDR2 comprising the amino acid sequence of XAK (SEQ ID NO: 477), wherein X at position 1 is N; and (vi) an LC CDR3 comprising the amino acid sequence of QXHYXVPWT (SEQ ID NO: 454), wherein X at position 2 is H and X at position 5 is T; and (b) an antigen-binding protein comprising the heavy chain (HC) CDR1-3 amino acid sequences of SEQ ID NOs: 23, 24, and 25, and the light chain (LC) CDR1-3 amino acid sequences of SEQ ID NOs: 20, 21, and 22,
Device for arrangement on current busbars , comprising a switching device and an electronics module , wherein the switching device has a front side , which is to be averted from the current busbars, a housing and fuse receptacles , which are arranged in a longitudinal direction (X) of the switching device , for receiving fuses, wherein a contact pair is assigned to the respective fuse receptacle , wherein one contact of the contact pair is connected to an input current conductor and the other contact of the contact pair is connected to an outgoing current conductor , and wherein the electronics module has a housing and a sensor component for voltage and/or current and/or energy measurement, a further-processing component for detecting and further processing an output signal of the sensor component or a pre-processed output signal of the sensor component and a transfer component for forwarding the output signal of the sensor component to the further-processing component or for preprocessing the output signal of the sensor component and forwarding the pre-processed output signal of the sensor component to the further-processing component , wherein the housing of the electronics module has a first housing section , a second housing section and a third housing section , wherein the sensor component is mounted in the first housing section , the transfer component is mounted in the second housing section and the further-processing component is mounted in the third housing section , characterized in that the switching device and the electronics module are detachably connected to each other, wherein the first housing section of the electronics module is arranged on a rear side of the switching device facing away from the front side and the second housing section and the third housing section of the electronics module protrude in the longitudinal direction (X) of the switching device in relation to the switching device .
Measuring arrangement , for monitoring a cable extending in a longitudinal direction, the cable having: - a cable core with at least one electrical line element for transmitting electrical data or electrical power, - a signal unit for feeding a measuring signal (S M ) into the cable core and for detecting a response signal (S A ), wherein the signal unit for feeding the measuring signal (S M ) is electrically connected to the at least one line element , wherein - a sensor unit is provided with a longitudinally extending sensor line , which is arranged inside the cable core , characterized by - a monitoring unit , which is designed to detect transmission pauses in the transmission of the electrical data or the electrical power, wherein - the signal unit is designed in such a way that, during operation, the measuring signal (S M ) is fed into the at least one line element as a function of the detected transmission pauses and the response signal (S A ) is detected and transmitted to an evaluation unit for evaluation. - a cable core with at least one electrical line element for transmitting electrical data or electrical power, - a signal unit for feeding a measuring signal (S M ) into the cable core and for detecting a response signal (S A ), wherein the signal unit for feeding the measuring signal (S M ) is electrically connected to the at least one line element , wherein - a sensor unit is provided with a longitudinally extending sensor line , which is arranged inside the cable core , characterized by - a monitoring unit , which is designed to detect transmission pauses in the transmission of the electrical data or the electrical power, wherein - the signal unit is designed in such a way that, during operation, the measuring signal (S M ) is fed into the at least one line element as a function of the detected transmission pauses and the response signal (S A ) is detected and transmitted to an evaluation unit for evaluation.
An antibody having an antigen-binding domain and an FcRn-binding region, wherein said antibody has a KD(pH5.8)/KD(pH7.4) value, defined as the ratio of KD for the antigen at pH5.8 and KD for the antigen at pH7.4, of 40 or higher; wherein at least one amino acid of a CDR of said antibody has been substituted with histidine; and wherein the KD(pH5.8)/KD(pH7.4) value is higher than the KD(pH5.8)/KD(pH7.4) value of the antibody before said histidine substitution.
Activation device for a battery for an electronic ignition mechanism, comprising an ampoule filled with an electrolyte and a device for breaking the ampoule , characterized in that the breaking device comprises two leaf spring elements , which are fixed with a prestress on a common component in the housing interior and between which the ampoule is clamped, at least the leaf spring element which supports the ampoule on the bottom side snapping from a first shape into a second shape when a force due to acceleration is applied.
A blood treatment apparatus , comprising a control or regulating apparatus , programmed to automatically execute a method for controlling and/or regulating the blood treatment apparatus in cooperation with the blood treatment apparatus when connected with the blood treatment apparatus , wherein the blood treatment apparatus comprises a blood pump for conveying the blood within an extracorporeal blood tubing set and is connected to the blood tubing set , wherein the blood tubing set respectively comprises and/or is respectively connected with an arterial section having an arterial needle and an arterial patient tubing clamp , a venous section having a venous needle and a venous patient tubing clamp , as well as a blood filter arranged between the sections having a membrane which separates a blood chamber from a dialysis fluid chamber , the method comprising the step of: - conveying fluid from the blood tubing set through the membrane into the dialysis fluid chamber by means of a pump when the venous patient tubing clamp is closed and - opening the venous patient tubing clamp . wherein the blood treatment apparatus comprises a blood pump for conveying the blood within an extracorporeal blood tubing set and is connected to the blood tubing set , wherein the blood tubing set respectively comprises and/or is respectively connected with an arterial section having an arterial needle and an arterial patient tubing clamp , a venous section having a venous needle and a venous patient tubing clamp , as well as a blood filter arranged between the sections having a membrane which separates a blood chamber from a dialysis fluid chamber , the method comprising the step of: - conveying fluid from the blood tubing set through the membrane into the dialysis fluid chamber by means of a pump when the venous patient tubing clamp is closed and - opening the venous patient tubing clamp . - conveying fluid from the blood tubing set through the membrane into the dialysis fluid chamber by means of a pump when the venous patient tubing clamp is closed and - opening the venous patient tubing clamp .