mhurhangee/patent-ind-claim-en huggingface dataset:
An oral, immediate release, abuse deterrent dosage form comprising: (i) an active substance susceptible to abuse; (ii) a matrix agent, wherein the matrix agent is polyethylene oxide, has an average molecular weight between 50K Daltons and 150K Daltons, and is 45 wt% to 55 wt% of the dosage form; and (iii) a plasticizer, wherein the plasticizer comprises polyalkalene glycol and has an average molecular weight between 1K Daltons and 15K Daltons, wherein the active substance susceptible to abuse has an immediate release profile such that the amount of said active substance released from the dosage form upon exposure to a de-aerated water within 45 minutes, as measured according to USP Monograph performed on a dissolution apparatus utilizing USP <711> Apparatus II (Paddles) with 500 mL de-aerated water as media and a paddle speed of 50 rpm, is greater than or equal to 75%, and wherein the composition includes a physical barrier to reduce abuse, wherein the physical barrier in the dosage form has at least 50 wt% of particles with a particle size greater than 0.5 mm following physical or mechanical manipulation of the dosage form; and wherein the dosage form is a formed, uniform extrudate having a uniform blend of active, matrix agent and plasticizer, and is directly formed from an extrusion process. (i) an active substance susceptible to abuse; (ii) a matrix agent, wherein the matrix agent is polyethylene oxide, has an average molecular weight between 50K Daltons and 150K Daltons, and is 45 wt% to 55 wt% of the dosage form; and (iii) a plasticizer, wherein the plasticizer comprises polyalkalene glycol and has an average molecular weight between 1K Daltons and 15K Daltons,
Object detection system for a motor vehicle, comprising: - one or more arrays of electroluminescent light sources ; - one or more arrays of light sensors ; - a calculating unit ; wherein at least one of the electroluminescent light sources is able to emit a signal, at least one of the sensors is able to receive the emitted signal that has been reflected by an object , the calculating unit is able to calculate, by triangulation, the position of the object on the basis of the position, in one of the arrays of electroluminescent light sources , of said at least one of the electroluminescent light sources able to emit a signal and of the position, in one of the arrays of light sensors, of said at least one of the sensors able to receive the signal reflected by the object . characterized in that one or more arrays of electroluminescent light sources are monolithic arrays of monolithic light-emitting diode arrays and in that said one or more one or more light sensor arrays are monolithic light-emitting diode arrays light-emitting diode arrays used as light sensors . - one or more arrays of electroluminescent light sources ; - one or more arrays of light sensors ; - a calculating unit ; wherein at least one of the electroluminescent light sources is able to emit a signal, at least one of the sensors is able to receive the emitted signal that has been reflected by an object , the calculating unit is able to calculate, by triangulation, the position of the object on the basis of the position, in one of the arrays of electroluminescent light sources , of said at least one of the electroluminescent light sources able to emit a signal and of the position, in one of the arrays of light sensors, of said at least one of the sensors able to receive the signal reflected by the object . characterized in that one or more arrays of electroluminescent light sources are monolithic arrays of monolithic light-emitting diode arrays and in that said one or more one or more light sensor arrays are monolithic light-emitting diode arrays light-emitting diode arrays used as light sensors .
A lens driving device, characterized by : a base ; a housing disposed on the base ; a bobbin disposed in the housing ; a first coil disposed on the bobbin ; a second coil disposed on the base ; a magnet disposed on the housing ; and an upper elastic member coupled with the housing and the bobbin , wherein the magnet comprises an upper surface facing the upper elastic member , wherein the upper surface of the magnet comprises a first portion overlapped with the upper elastic member and not overlapped with the housing in an optical axis direction, and a second portion overlapped with the housing and not overlapped with the upper elastic member in the optical axis direction. a base ; a housing disposed on the base ; a bobbin disposed in the housing ; a first coil disposed on the bobbin ; a second coil disposed on the base ; a magnet disposed on the housing ; and an upper elastic member coupled with the housing and the bobbin , wherein the magnet comprises an upper surface facing the upper elastic member , wherein the upper surface of the magnet comprises a first portion overlapped with the upper elastic member and not overlapped with the housing in an optical axis direction, and a second portion overlapped with the housing and not overlapped with the upper elastic member in the optical axis direction.
Syringe with a bonded needle , comprising: - a body of a syringe, - a needle guard , comprising a flexible tip , - an outer sleeve , which is movable along a longitudinal axis (X1) between an advanced position where it covers the needle, and a retracted position where it does not cover the needle, and - a collar , which is mounted with a radial clearance (J1) around an end portion of the syringe body , and which comprises at least one pin engaged in a guide opening of the sleeve, characterized in that a part of the flexible tip fills the radial clearance (J1) between the end part of the syringe body and the collar when the tip is mounted on the syringe, so that the collar is immobilized in rotation about the end part of the syringe body as long as the tip is mounted on the syringe. - a body of a syringe, - a needle guard , comprising a flexible tip , - an outer sleeve , which is movable along a longitudinal axis (X1) between an advanced position where it covers the needle, and a retracted position where it does not cover the needle, and - a collar , which is mounted with a radial clearance (J1) around an end portion of the syringe body , and which comprises at least one pin engaged in a guide opening of the sleeve,
A power stage for a DC-to-DC voltage converter, the power stage comprising: a voltage input configured to be coupled to a supply voltage ; a high-side n-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the drain terminal being coupled to the voltage input and the source terminal being coupled to a first node (N1) that is configured to be coupled to an output stage of the DC-to-DC converter; a high-side p-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the source terminal being coupled to the voltage input and the drain terminal being coupled to the first node; and a low-side n-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the drain terminal being coupled to the first node and the source terminal being coupled to a ground; control circuitry configured to receive information regarding the supply voltage and configured to cause the high-side n-channel transistor to serve as the active high-side transistor of the DC-to-DC converter, while deactivating the high-side p-channel transistor , if the supply voltage is below a predetermined threshold value (Vth), and configured to cause the high-side p-channel transistor to serve as the active high-side transistor of the DC-to-DC converter, while deactivating the high-side n-channel transistor , if the supply voltage is above the predetermined threshold value. a voltage input configured to be coupled to a supply voltage ; a high-side n-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the drain terminal being coupled to the voltage input and the source terminal being coupled to a first node (N1) that is configured to be coupled to an output stage of the DC-to-DC converter; a high-side p-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the source terminal being coupled to the voltage input and the drain terminal being coupled to the first node; and a low-side n-channel transistor comprising a source terminal, a drain terminal and a gate terminal, the drain terminal being coupled to the first node and the source terminal being coupled to a ground; control circuitry configured to receive information regarding the supply voltage and configured to cause the high-side n-channel transistor to serve as the active high-side transistor of the DC-to-DC converter, while deactivating the high-side p-channel transistor , if the supply voltage is below a predetermined threshold value (Vth), and configured to cause the high-side p-channel transistor to serve as the active high-side transistor of the DC-to-DC converter, while deactivating the high-side n-channel transistor , if the supply voltage is above the predetermined threshold value.
An aqueous composition comprising in the aqueous phase - microcapsules which comprise a shell and a core, where the core contains a pesticide; - and a codispersant of the formula (I) R-X (I) in which R has 6 to 10 carbon atoms and is alkyl, arylalkyl, or alkylaryl; X is -O-PO 3 H 2 , -CO 2 H, -O-SO 3 H, -SO 3 H, or salts thereof. - microcapsules which comprise a shell and a core, where the core contains a pesticide; - and a codispersant of the formula (I) R-X (I) in which R has 6 to 10 carbon atoms and is alkyl, arylalkyl, or alkylaryl; X is -O-PO 3 H 2 , -CO 2 H, -O-SO 3 H, -SO 3 H, or salts thereof. R has 6 to 10 carbon atoms and is alkyl, arylalkyl, or alkylaryl; X is -O-PO 3 H 2 , -CO 2 H, -O-SO 3 H, -SO 3 H, or salts thereof.
Cosmetic or dermatological composition in the form of an oil-in-water nanoemulsion, characterized in that it comprises: - a lipophilic phase (a) which comprises at least one hydrocarbon-based oil comprising at least one isoparaffin, and at least one cycloalkane, - an emulsifying system (b) comprising at least 95% by weight of emulsifiers chosen from adducts of ethylene oxide with cetearyl or cetylstearyl alcohol comprising from 10 to 20 oxyethylene groups, glyceryl stearate and cetearyl alcohol, relative to the total weight of the emulsifying system, - an aqueous phase (c), - the lipophilic phase (a)/emulsifying system (b) weight ratio being greater than or equal to 0.5. - a lipophilic phase (a) which comprises at least one hydrocarbon-based oil comprising at least one isoparaffin, and at least one cycloalkane, - an emulsifying system (b) comprising at least 95% by weight of emulsifiers chosen from adducts of ethylene oxide with cetearyl or cetylstearyl alcohol comprising from 10 to 20 oxyethylene groups, glyceryl stearate and cetearyl alcohol, relative to the total weight of the emulsifying system, - an aqueous phase (c), - the lipophilic phase (a)/emulsifying system (b) weight ratio being greater than or equal to 0.5.
A method for diagnosing an injection device for a combustion engine , wherein the injection device has a volume with at least one inlet , via which the volume can be fluidically connected to a pressure line , and a plurality of outlets , via which the volume can be connected to a plurality of combustion chambers of the combustion engine ; wherein the injection device further comprises a first pressure sensor for measuring a pressure in the volume ; wherein the combustion engine comprises the plurality of combustion chambers , the injection device , and a device for the lambda control of the combustion engine, wherein a fuel can be supplied to the combustion chambers via the injection device ; wherein the method comprises at least the following steps: a) determining a first state of the injection device in which the at least one inlet and the outlets are closed and the volume has a constant volume ; wherein the volume is completely filled by a liquid provided for injection; b) measuring a first pressure at a first point in time ; c) measuring a second pressure at a later second point in time ; d) evaluating a pressure change from the first pressure to the second pressure ; wherein, by the evaluation according to step d), a total leakage of the injection device is ascertained; wherein starting from the total leakage, a leakage via the outlets is ascertained via an evaluation of the lambda control of the combustion engine ; wherein, via the lambda control, that is, by measuring the content of air in the exhaust gas, it is determined whether the liquid has arrived in the combustion chambers via the outlets ; wherein the lambda control is performed for each combustion chamber so that the outlet through which leakage occurs is determined by the method. a) determining a first state of the injection device in which the at least one inlet and the outlets are closed and the volume has a constant volume ; wherein the volume is completely filled by a liquid provided for injection; b) measuring a first pressure at a first point in time ; c) measuring a second pressure at a later second point in time ; d) evaluating a pressure change from the first pressure to the second pressure ;
A four-wheel drive vehicle (10; 10; 200; 210; 220; 230; 240) comprising: a dog clutch selectively disconnecting or connecting a power transmission path between an input rotating member to which a portion of a drive power from a drive power source toward main drive wheels is input and an output rotating member coupled to sub-drive wheels in a power transmittable manner; an electronically controlled coupling disposed on a power transmission path between the drive power source and the sub-drive wheels and adjusting the drive power transmitted from the drive power source to the sub-drive wheels; and a control device providing a switching control between a four-wheel drive state in which the dog clutch is brought into an engaged state while the electronically controlled coupling is brought into an engaged state and a two-wheel drive state in which the dog clutch is brought into a released state, the control device switching a drive state to the four-wheel drive state when the control device determines that a running road surface is a low friction road and switching the drive state to the two-wheel drive state when the control device determines that the running road surface is a high friction road, wherein in the case of switching the drive state from the four-wheel drive state to the two-wheel drive state, the control device temporarily releases the electronically controlled coupling to redetermine whether the running road surface is the low friction road or the high friction road before releasing the dog clutch and prohibits switching from the four-wheel drive state to the two-wheel drive state when it is redetermined that the running road surface is the low friction road.
Rotating electric machine comprising: - a stator having a winding head at each axial end and - a rotor which is rotatably mounted in an opening in the stator and which has a rotor shaft and a laminated rotor core , - a bearing unit for the rotatable mounting of the rotor shaft with respect to the laminated rotor core , - a transmission unit , - a coupling unit , which is designed to provide at least two coupling states for coupling the rotor shaft rotationally to the laminated rotor core and, in at least one of the coupling states, to couple the rotor shaft to the laminated rotor core by means of the transmission unit , characterized in that in one of the coupling states, the coupling unit is designed to rotationally couple the rotor shaft directly to the laminated rotor core , wherein the coupling unit provides a frictional coupling element which, for example, at one of the front ends of the laminated rotor core , couples this frictionally, so that the rotational coupling between the rotor shaft and the laminated rotor core is produced. - a stator having a winding head at each axial end and - a rotor which is rotatably mounted in an opening in the stator and which has a rotor shaft and a laminated rotor core , - a bearing unit for the rotatable mounting of the rotor shaft with respect to the laminated rotor core , - a transmission unit , - a coupling unit , which is designed to provide at least two coupling states for coupling the rotor shaft rotationally to the laminated rotor core and, in at least one of the coupling states, to couple the rotor shaft to the laminated rotor core by means of the transmission unit ,
A Nectin-4-binding protein conjugated to a camptothecin analogue for use in the treatment of a cancer in an individual, wherein the Nectin-4-binding protein conjugated to a camptothecin analogue is an immunoconjugate represented by Formula (I): Ab-(X-(Z)) Formula (I) wherein, Ab is an antibody that specifically binds to a human Nectin-4 polypeptide; X is a linker molecule which connects Ab and Z, wherein X comprises a moiety that is cleavable under physiological conditions, optionally under intracellular conditions, optionally a protease-cleavable di-, tri-, tetra- or penta-peptide, optionally wherein X further comprises a self-eliminating spacer positioned between the protease-cleavable peptide and Z; and Z is an exatecan molecule, and wherein the cancer has relapsed and/or has progressed following treatment with a Nectin-4-binding agent conjugated to an auristatin. Ab is an antibody that specifically binds to a human Nectin-4 polypeptide; X is a linker molecule which connects Ab and Z, wherein X comprises a moiety that is cleavable under physiological conditions, optionally under intracellular conditions, optionally a protease-cleavable di-, tri-, tetra- or penta-peptide, optionally wherein X further comprises a self-eliminating spacer positioned between the protease-cleavable peptide and Z; and Z is an exatecan molecule, and wherein the cancer has relapsed and/or has progressed following treatment with a Nectin-4-binding agent conjugated to an auristatin.
A method comprising: obtaining an aluminum sheet comprising a 3xxx or a 5xxx alloy; wherein the aluminum sheet has a tensile yield strength as measured in the longitudinal direction of 186-228 MPa (27-33 ksi) and an ultimate tensile strength; wherein the ultimate tensile strength minus the tensile yield strength is less than 22.8 MPa (3.30 ksi) (UTS-TYS < 22.8 MPa (3.30 ksi)); and wherein the aluminum sheet has a thickness of 0.015 cm to 0.076 cm (0.006 inch to 0.030 inch); drawing and ironing the aluminum sheet to form an aluminum container having a dome; necking the aluminum container to reduce a diameter of a portion of the aluminum container to form a bottle; and finishing the bottle so as to result in the bottle configured to accept a closure. obtaining an aluminum sheet comprising a 3xxx or a 5xxx alloy; wherein the aluminum sheet has a tensile yield strength as measured in the longitudinal direction of 186-228 MPa (27-33 ksi) and an ultimate tensile strength; wherein the ultimate tensile strength minus the tensile yield strength is less than 22.8 MPa (3.30 ksi) (UTS-TYS < 22.8 MPa (3.30 ksi)); and wherein the aluminum sheet has a thickness of 0.015 cm to 0.076 cm (0.006 inch to 0.030 inch); drawing and ironing the aluminum sheet to form an aluminum container having a dome; necking the aluminum container to reduce a diameter of a portion of the aluminum container to form a bottle; and finishing the bottle so as to result in the bottle configured to accept a closure.
A mounting system for mounting an electronic component in a housing , the mounting system comprising a damping element configured for damping the transmission of vibration from the housing to the component in use, and a support for supporting the component in the housing ; wherein the support is configured for supporting the component in the housing independently of the damping element such that the weight of the component is substantially or completely removed from the damping element , the support further being configured to be selectively releasable from the component such that the component is then supported only by the damping element ; characterised in that the support is configured to be collapsible or permanently deformable upon a predetermined movement of the component relative to the housing so as to release the component .
An assembly for use in an internal combustion engine comprising: a cylinder having a bore diameter; a piston disposed within the cylinder , the piston having a top land having a top land height and a top ring groove ; the top land and the cylinder having a tight top land clearance; and wherein the ratio of the top land height to the bore diameter is less than or equal to 0.025 characterised in that : the tight top land clearance is between 0 microns and 35 microns when the internal combustion engine operates at rated temperatures, wherein the piston is either made of steel and the tight top land clearance is less than 0.29% of the bore diameter at room temperature for a lean burn engine, and less than 0.33% of the bore diameter at room temperature for a stoichiometric burn engine or wherein the piston is made of aluminum and the tight top land clearance is less than 0.46% of the bore diameter at room temperature for a lean burn engine and less than 0.53% of the bore diameter for a stoichiometric burn engine. a cylinder having a bore diameter; a piston disposed within the cylinder , the piston having a top land having a top land height and a top ring groove ; the top land and the cylinder having a tight top land clearance; and wherein the ratio of the top land height to the bore diameter is less than or equal to 0.025 characterised in that : the tight top land clearance is between 0 microns and 35 microns when the internal combustion engine operates at rated temperatures, wherein the piston is either made of steel and the tight top land clearance is less than 0.29% of the bore diameter at room temperature for a lean burn engine, and less than 0.33% of the bore diameter at room temperature for a stoichiometric burn engine or wherein the piston is made of aluminum and the tight top land clearance is less than 0.46% of the bore diameter at room temperature for a lean burn engine and less than 0.53% of the bore diameter for a stoichiometric burn engine. the tight top land clearance is between 0 microns and 35 microns when the internal combustion engine operates at rated temperatures, wherein the piston is either made of steel and the tight top land clearance is less than 0.29% of the bore diameter at room temperature for a lean burn engine, and less than 0.33% of the bore diameter at room temperature for a stoichiometric burn engine or wherein the piston is made of aluminum and the tight top land clearance is less than 0.46% of the bore diameter at room temperature for a lean burn engine and less than 0.53% of the bore diameter for a stoichiometric burn engine.