A syringe assembly for dispensing medicine from a cartridge (C) having a diaphragm (D) and a piston (P) opposite the diaphragm (D), said assembly comprising: a barrel having a hollow interior , an open proximal end extending into the hollow interior , a closed distal end opposite the proximal end, and an outlet adapted for fluid communication with a delivery needle for delivering medicine to tissue of a subject; and a cartridge receiver slidably receivable in the hollow interior of the barrel , the cartridge receiver including an interior space sized and shaped for receiving the cartridge (C), an access needle extending into the interior space of the cartridge receiver for puncturing the diaphragm (D) of the cartridge (C) received in the interior space to access medicine therein, the access needle directing fluid to the barrel outlet when the diaphragm (D) is pierced by the access needle , and a plunger rod movable into the interior space of the cartridge receiver for engaging the piston of the cartridge (C) received in the receiver to selectively force medicine in the cartridge (C) through the access needle , characterised in that the cartridge receiver includes a cartridge receiver thumb ring for manipulating the assembly when dispensing medicine from the cartridge (C), and in that the plunger rod includes a plunger rod thumb ring for manipulating the assembly when dispensing medicine from the cartridge (C), said cartridge receiver thumb ring and said plunger rod thumb ring being concentrically aligned when the cartridge (C) is in the interior space of the cartridge receiver , the access needle is fully inserted in the diaphragm (D) of the cartridge (C), and the plunger rod is engaging the piston (P) of the cartridge (C). a barrel having a hollow interior , an open proximal end extending into the hollow interior , a closed distal end opposite the proximal end, and an outlet adapted for fluid communication with a delivery needle for delivering medicine to tissue of a subject; and a cartridge receiver slidably receivable in the hollow interior of the barrel , the cartridge receiver including an interior space sized and shaped for receiving the cartridge (C), an access needle extending into the interior space of the cartridge receiver for puncturing the diaphragm (D) of the cartridge (C) received in the interior space to access medicine therein, the access needle directing fluid to the barrel outlet when the diaphragm (D) is pierced by the access needle , and a plunger rod movable into the interior space of the cartridge receiver for engaging the piston of the cartridge (C) received in the receiver to selectively force medicine in the cartridge (C) through the access needle , characterised in that the cartridge receiver includes a cartridge receiver thumb ring for manipulating the assembly when dispensing medicine from the cartridge (C), and in that the plunger rod includes a plunger rod thumb ring for manipulating the assembly when dispensing medicine from the cartridge (C), said cartridge receiver thumb ring and said plunger rod thumb ring being concentrically aligned when the cartridge (C) is in the interior space of the cartridge receiver , the access needle is fully inserted in the diaphragm (D) of the cartridge (C), and the plunger rod is engaging the piston (P) of the cartridge (C). <EOS>