mhurhangee/patent-ind-claim-en huggingface dataset:
A medicament for use in treating a fibrotic disease associated with myofibroblast differentiation or a secondary disease state or condition thereof in a subject, wherein the fibrotic disease or secondary disease state or condition thereof is selected from the group consisting of liver fibrosis, renal fibrosis, lung fibrosis, hypersensitivity pneumonitis, ischemic-reperfusion injury, interstitial fibrosis, systemic scleroderma, chronic allograft vasculopathy and/or chronic rejection in transplanted organs, ischemic-reperfusion injury associated fibrosis, macular degeneration, pancreatic fibrosis, fibrosis of organ transplant recipients, fibrosis of the spleen, cardiac fibrosis, mediastinal fibrosis, myelofibrosis, endomyocardial fibrosis, retroperitoneal fibrosis, progressive massive fibrosis, nephrogenic systemic fibrosis, fibrotic complications of surgery, injection fibrosis, cirrhosis, diffuse parenchymal lung disease, post-vasectomy pain syndrome, stiff skin syndrome, rheumatoid arthritis and cancer of epithelial origin, and wherein the subject is one severely afflicted with a fibrotic disease and has been diagnosed as having a pathological level and/or activity of CAPN9, said medicament comprising at least one agent that decreases the level and/or activity of CAPN9, wherein the at least one agent is a compound selected from Molecule Name Calpeptin Calpain Inhibitor IV SJA-6017 MDL-28170 Z-Leu-Leu-CHO NapSul-Ile-Trp-CHO Boc-Gly-Val-Val-CHO Calpain Inhibitor II (ALLM) E-64 E-64-C Z-VAD-FMK Z-FA-FMK E-64-d Aloxistatin 5-Nitroisatin Leupeptin Hemisulfate
A crosslinkable polyester prepared by free radical polymerization of the double bonds of an unsaturated polyester prepolymer, wherein the number average functionality of the unsaturation in the prepolymer is 0.05 to 25, and wherein the polyester does not comprise (meth)acrylate or residues thereof.
A system , comprising: a transmitter to generate a power beam ; a receiver to receive at least a portion of the power beam; a plurality of sensors arranged to independently detect when an object is impinging on the power beam, at least a first set of one or more sensors of the plurality of sensors arranged to detect the object at or within a first detection volume between the transmitter and the receiver, at least a second set of one or more sensors of the plurality of sensors arranged to detect the object at or within a second detection volume between the transmitter and the receiver, the first detection volume including a first distance range from the transmitter and the second detection volume including a second distance range from the transmitter, the first distance range being different from the second distance range; and a controller to interrupt transmission of the power beam to the receiver when, based on information from one or more of the plurality of sensors, the object is determined to be impinging on the power beam. a transmitter to generate a power beam ; a receiver to receive at least a portion of the power beam; a plurality of sensors arranged to independently detect when an object is impinging on the power beam, at least a first set of one or more sensors of the plurality of sensors arranged to detect the object at or within a first detection volume between the transmitter and the receiver, at least a second set of one or more sensors of the plurality of sensors arranged to detect the object at or within a second detection volume between the transmitter and the receiver, the first detection volume including a first distance range from the transmitter and the second detection volume including a second distance range from the transmitter, the first distance range being different from the second distance range; and a controller to interrupt transmission of the power beam to the receiver when, based on information from one or more of the plurality of sensors, the object is determined to be impinging on the power beam.
A DNA construct for use in a viral vector production system, wherein the viral vector production system comprises a set of nucleic acid sequences encoding the components required for the production of the viral vector, wherein the vector genome comprises a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell, wherein the DNA construct comprises a nucleic acid sequence with a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell, wherein the RNA-binding protein is tryptophan RNA-binding attenuation protein (TRAP), wherein the nucleotide of interest gives rise to a therapeutic effect. wherein the viral vector production system comprises a set of nucleic acid sequences encoding the components required for the production of the viral vector, wherein the vector genome comprises a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell, wherein the DNA construct comprises a nucleic acid sequence with a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell, wherein the RNA-binding protein is tryptophan RNA-binding attenuation protein (TRAP), wherein the nucleotide of interest gives rise to a therapeutic effect.
A reduction gear for driving a stirred mill, of the type comprising: - a reduction gear housing , - an input shaft suitable for being connected to a drive motor, - a reduction stage arranged in the reduction gear housing, and - an output shaft , which extends along an output axis (Y-Y), characterized in that this output shaft is suitable for being connected to a stirred mill element and which is suitable for being driven by the reduction stage, - the output shaft comprises a proximal axial side, associated with the reduction stage , and a distal axial side, opposite the proximal axial side and intended to be fastened to the stirred mill element, and in that - the reduction gear comprises an axial stop , which is suitable for axially guiding the output shaft and which is suitable for limiting an axial movement of the output shaft in a direction oriented from the proximal axial side toward the distal axial side. - a reduction gear housing , - an input shaft suitable for being connected to a drive motor, - a reduction stage arranged in the reduction gear housing, and - an output shaft , which extends along an output axis (Y-Y), characterized in that this output shaft is suitable for being connected to a stirred mill element and which is suitable for being driven by the reduction stage, - the output shaft comprises a proximal axial side, associated with the reduction stage , and a distal axial side, opposite the proximal axial side and intended to be fastened to the stirred mill element, and in that - the reduction gear comprises an axial stop , which is suitable for axially guiding the output shaft and which is suitable for limiting an axial movement of the output shaft in a direction oriented from the proximal axial side toward the distal axial side.
An external rotor electric machine comprising: an internal stator ; and an external rotor coaxial to the internal stator; the external rotor including an inner surface facing the internal stator; the external rotor including permanent magnets arranged in a circumferential direction on the internal surface of the rotor, and magnetically susceptible protrusions respectively arranged between adjacent permanent magnets; the magnetically susceptible protrusions being so configured and sized as to position the magnets with a non equal angular spacing between consecutive adjacent magnets so as to reduce cogging torque and torque ripple, wherein the protrusions consist of individual ring segments including a central protrusion , two lateral protrusions and two permanent magnet receiving portions , one lateral protrusion and one permanent magnet receiving portion located on each side of the central protrusion, wherein each permanent magnet receiving portion is located between the central protrusion and one of the lateral protrusions , and rounded notches between the central and lateral protrusions and the respective permanent magnet receiving portions . an internal stator ; and an external rotor coaxial to the internal stator; the external rotor including an inner surface facing the internal stator; the external rotor including permanent magnets arranged in a circumferential direction on the internal surface of the rotor, and magnetically susceptible protrusions respectively arranged between adjacent permanent magnets; the magnetically susceptible protrusions being so configured and sized as to position the magnets with a non equal angular spacing between consecutive adjacent magnets so as to reduce cogging torque and torque ripple, wherein the protrusions consist of individual ring segments including a central protrusion , two lateral protrusions and two permanent magnet receiving portions , one lateral protrusion and one permanent magnet receiving portion located on each side of the central protrusion, wherein each permanent magnet receiving portion is located between the central protrusion and one of the lateral protrusions , and rounded notches between the central and lateral protrusions and the respective permanent magnet receiving portions .
A method of tuning an electric charge extraction circuit of a vibrational energy harvester having a mechanical resonator , the method comprising: - varying, during a first phase (PHASE 1), first and second parameters (ψ 1 ,ψ 2 ) of the electric charge extraction circuit based on detected harvested power (P HARVEST ), each of the first and second parameters (ψ 1 ,ψ 2 ) influencing the amount of damping (ξ e ) of the mechanical resonator and at least the first parameter (Ψ 1 ) influencing the resonance frequency (f res ) of the mechanical resonator , wherein the first and second parameters (ψ 1 ,ψ 2 ) are varied during the first phase (PHASE 1) such that the amount of damping (ξ e ) remains constant or varies by less than a first significant amount and the resonance frequency reaches a final level (f res '). - varying, during a first phase (PHASE 1), first and second parameters (ψ 1 ,ψ 2 ) of the electric charge extraction circuit based on detected harvested power (P HARVEST ), each of the first and second parameters (ψ 1 ,ψ 2 ) influencing the amount of damping (ξ e ) of the mechanical resonator and at least the first parameter (Ψ 1 ) influencing the resonance frequency (f res ) of the mechanical resonator , wherein the first and second parameters (ψ 1 ,ψ 2 ) are varied during the first phase (PHASE 1) such that the amount of damping (ξ e ) remains constant or varies by less than a first significant amount and the resonance frequency reaches a final level (f res ').
An injectable formulation for magnetic field induced hyperthermia treatment of selected cells comprising: a liquid carrier; and two or more populations of nanoparticles, wherein each population of nanoparticles has a mean Curie temperature in the range 37 to 47 °C and wherein the mean Curie temperature of each population of the two or more populations of nanoparticles differs from the mean Curie temperature of each of the remaining populations of nanoparticles by at least 2 °C. a liquid carrier; and two or more populations of nanoparticles, wherein each population of nanoparticles has a mean Curie temperature in the range 37 to 47 °C and wherein the mean Curie temperature of each population of the two or more populations of nanoparticles differs from the mean Curie temperature of each of the remaining populations of nanoparticles by at least 2 °C.
Method for manufacturing a two-dimensional colour bar code comprising an arrangement of coloured basic structural elements encoding at least one element of information, said manufacturing method comprising the following steps: - determining (E304), by means of data processing means, a set of coloured basic structural elements corresponding to said at least one element of information, at least one structural element in the set comprising a pattern, and - forming (E308) said at least one structural element in the set on a base , in order to create the arrangement of coloured basic structural elements , in which: - the base comprises a printed matrix comprising a plurality of pixels , each pixel comprising at least two sub-pixels of different colours, and - forming said at least one coloured basic structural element comprises modifying the base at the level of at least one portion of at least one sub-pixel of at least one pixel in the matrix , said modification making it possible to obtain the colour and the pattern of said at least one basic structural element . - determining (E304), by means of data processing means, a set of coloured basic structural elements corresponding to said at least one element of information, at least one structural element in the set comprising a pattern, and - forming (E308) said at least one structural element in the set on a base , in order to create the arrangement of coloured basic structural elements , - the base comprises a printed matrix comprising a plurality of pixels , each pixel comprising at least two sub-pixels of different colours, and - forming said at least one coloured basic structural element comprises modifying the base at the level of at least one portion of at least one sub-pixel of at least one pixel in the matrix , said modification making it possible to obtain the colour and the pattern of said at least one basic structural element .
A Laves phase intermetallic compound having a composition represented by general formula ARu 2 , wherein A is Y, Sc, or at least one element selected from lanthanoid elements excluding Ce; a crystallite size of the Laves phase intermetallic compound is 1 nm to 100 nm, and a specific surface area of the Laves phase intermetallic compound is 0.5 m 2 /g or more. wherein A is Y, Sc, or at least one element selected from lanthanoid elements excluding Ce; a crystallite size of the Laves phase intermetallic compound is 1 nm to 100 nm, and a specific surface area of the Laves phase intermetallic compound is 0.5 m 2 /g or more.
Carding machine having a cylinder rotatably mounted between two side panels, wherein in each case at least one flexible bend is directly or indirectly arranged on a side panel so as to be adjustable by means of a plurality of setting points, and at least one slide rail for guiding a plurality of revolving flat bars of a revolving flat system is arranged at or on each flexible bend , wherein each slide rail consists of two slide rails oriented in a wedge shape relative to one another, wherein an upper slide rail is displaceably arranged on a lower slide rail , characterised in that the flexible bend is directly or indirectly arranged on the side panel so as to be adjustable concentrically with respect to the cylinder at at least eight adjustment points (19a-19f, 24), wherein the distance of the adjustment points (19a-19f, 24) from one another decreases from the middle of the flexible bend to its ends.
Cooling apparatus for a hydraulic assembly, the cooling apparatus having a container for hydraulic oil, which container has an inlet and an outlet , at least two heat pipes being arranged in the flow path of the hydraulic oil between the inlet and the outlet , each heat pipe having a coolant, and each heat pipe being immersed with one pipe section into the container , in order to dissipate heat from the hydraulic oil as heat of evaporation, by the coolant evaporating at a location to be cooled, the heat pipes not being arranged in series as viewed in the direction of the flow path .
A tensioner comprising: a base having a base aperture , the base aperture having an axis A-A and capable of receiving a driven component (P); a rotary arm rotatably engaged with the base and encircling the base aperture ; a swing arm pivotally engaged with the rotary arm , a first torsion spring biasing the swing arm , a first pulley journalled to the swing arm ; and characterised by : a rotary ring rotatably encircling the base aperture and disposed between the rotary arm and the base , a second pulley journalled to the rotary ring ; a second torsion spring engaged between the rotary ring and the rotary arm for biasing the rotary ring ; and a wave spring in pressing engagement between the base and the rotary ring . a base having a base aperture , the base aperture having an axis A-A and capable of receiving a driven component (P); a rotary arm rotatably engaged with the base and encircling the base aperture ; a swing arm pivotally engaged with the rotary arm , a first torsion spring biasing the swing arm , a first pulley journalled to the swing arm ; and characterised by : a rotary ring rotatably encircling the base aperture and disposed between the rotary arm and the base , a second pulley journalled to the rotary ring ; a second torsion spring engaged between the rotary ring and the rotary arm for biasing the rotary ring ; and a wave spring in pressing engagement between the base and the rotary ring . a rotary ring rotatably encircling the base aperture and disposed between the rotary arm and the base , a second pulley journalled to the rotary ring ; a second torsion spring engaged between the rotary ring and the rotary arm for biasing the rotary ring ; and a wave spring in pressing engagement between the base and the rotary ring .
Anti-climbing device for a rail vehicle, comprising a full plate , a plurality of projecting first shaped-out formations with a straight course which are parallel to one another being arranged on the baffle plate , and a plurality of projecting second shaped-out formations with a straight course which are parallel to one another and are oriented perpendicularly with respect to the first shaped-out formations being arranged on the baffle plate , and the extent of the second shaped-out formations over the surface area of the baffle plate being smaller than the extent of the first shaped-out formations over the surface area of the baffle plate , characterized in that , at crossing points of the shaped-out formations , the first shaped-out formations have in each case one recess , in which the extent of the first shaped-out formation is reduced.
A single compartment gas permeable cell culture device for culturing cells that settle out of medium by gravity, the device comprising a static cell culture container including a bottom connected to a top by a sidewall, and a medium access port to said container, wherein said bottom is comprised of gas permeable material in contact with a gas permeable material support that allows ambient gas to make contact with the gas permeable material by passive diffusion without ancillary pumping mechanisms to pump gas and the gas permeable material support holds the gas permeable material in a horizontal state such that cells do not pile up in any low points, and said device is capable of holding a volume in contact with the gas permeable material whereby the uppermost surface of the volume of medium is at a height of 5.09cm above the gas permeable material.
A game controller comprising: a housing ; and a vibrator placed in the housing and capable of vibrating in a first direction and a second direction different from the first direction, wherein the vibrator is configured to come into contact with the housing at least on a first surface of the vibrator corresponding to the first direction, wherein the first surface is substantially orthogonal to the first direction, wherein the vibrator is accommodated in a holder which is fixed to the housing , and the holder is formed of an elastic material and is press-fitted to a vibration fixing portion of the housing , and wherein the first surface of the vibrator corresponding to the first direction comes into contact with a planar surface portion of an inner surface of the housing. a housing ; and a vibrator placed in the housing and capable of vibrating in a first direction and a second direction different from the first direction, wherein the vibrator is configured to come into contact with the housing at least on a first surface of the vibrator corresponding to the first direction, wherein the first surface is substantially orthogonal to the first direction, wherein the vibrator is accommodated in a holder which is fixed to the housing , and the holder is formed of an elastic material and is press-fitted to a vibration fixing portion of the housing , and
A computer-implemented method for generating three-dimensional images of a target region of a patient, the method comprising: receiving a plurality of non-parallel projection images of the target region of the patient, each image of the plurality of non-parallel projection images being generated using a projection beam having a plurality of diverging rays ; converting the plurality of non-parallel projection images into a non-spatial domain using a plurality of vectors , each vector being a unique label for each ray of the plurality of rays, wherein the vectors are perpendicular to respective rays of the plurality of rays, and connect an isocenter of the projection beam with the closest point to the isocenter along each ray; reconstructing a three-dimensional image from the plurality of non-parallel projection images in the non-spatial domain; and converting the reconstructed three-dimensional image from the non-spatial domain to the spatial domain. receiving a plurality of non-parallel projection images of the target region of the patient, each image of the plurality of non-parallel projection images being generated using a projection beam having a plurality of diverging rays ; converting the plurality of non-parallel projection images into a non-spatial domain using a plurality of vectors , each vector being a unique label for each ray of the plurality of rays, wherein the vectors are perpendicular to respective rays of the plurality of rays, and connect an isocenter of the projection beam with the closest point to the isocenter along each ray; reconstructing a three-dimensional image from the plurality of non-parallel projection images in the non-spatial domain; and converting the reconstructed three-dimensional image from the non-spatial domain to the spatial domain.
A method comprising: combining an interlayer and a carbon fiber fabric, wherein the interlayer comprises a highly oriented milled carbon fiber ply comprising a plurality of out-of-plane carbon fibers; winding the interlayer and the carbon fiber fabric around a core to form a composite fiber preform comprising a plurality of layers defining an annulus extending along a central axis; and densifying the composite fiber preform. combining an interlayer and a carbon fiber fabric, wherein the interlayer comprises a highly oriented milled carbon fiber ply comprising a plurality of out-of-plane carbon fibers; winding the interlayer and the carbon fiber fabric around a core to form a composite fiber preform comprising a plurality of layers defining an annulus extending along a central axis; and densifying the composite fiber preform.