mhurhangee/patent-ind-claim-en huggingface dataset:
A compound-coupled antibody, comprising an antibody that binds a transferrin receptor (TfR), which is coupled to a compound that is a neurological disorder drug, for use in a method of treating a neurological disorder in a mammal while decreasing or eliminating reduction of reticulocytes associated with administration of the compound-coupled anti-TfR antibody, wherein the compound-coupled antibody has an affinity for the TfR from 50 nM to 1 μM measured as a K D by BIACORE, and wherein the antibody: a) is a Fab fragment; b) has an IgG4 isotype; or c) has a mutation at position 297 of the Fc region of the antibody such that the wild-type asparagine residue at that position is replaced with another amino acid that interferes with glycosylation at that position, wherein amino acid numbering is according to the EU numbering system. comprising an antibody that binds a transferrin receptor (TfR), which is coupled to a compound that is a neurological disorder drug, for use in a method of treating a neurological disorder in a mammal while decreasing or eliminating reduction of reticulocytes associated with administration of the compound-coupled anti-TfR antibody, wherein the compound-coupled antibody has an affinity for the TfR from 50 nM to 1 μM measured as a K D by BIACORE, and wherein the antibody: a) is a Fab fragment; b) has an IgG4 isotype; or c) has a mutation at position 297 of the Fc region of the antibody such that the wild-type asparagine residue at that position is replaced with another amino acid that interferes with glycosylation at that position, wherein amino acid numbering is according to the EU numbering system. a) is a Fab fragment; b) has an IgG4 isotype; or c) has a mutation at position 297 of the Fc region of the antibody such that the wild-type asparagine residue at that position is replaced with another amino acid that interferes with glycosylation at that position, wherein amino acid numbering is according to the EU numbering system.
Method for processing transaction data, the method being implemented by means of a communications terminal (TC) having a touchscreen (Tac), method of the type comprising an entry, during a transaction, on said touchscreen (Tac) of said communications terminal (TC), of a piece of personal data of a user, the method comprising, in the communications terminal (TC), a step for detecting a necessity of entering a piece of personal identification data (DIP), said method being characterized in that it further comprises: - a step of transmission , to a card reader (LecC) connected to the communications terminal (TC), of a request (RqP) for supporting the display of a virtual keypad (VK), said request (RqP) comprising a piece of data representing a passage of said communications terminal from a mode of operation called a "master" mode to a mode of operation called a "slave" mode, said second mode of operation leading to the implementation of said method for processing transaction data under the exclusive control of the card reader; - a step of entry , by said user on said virtual keypad (VK), of the piece of personal identification data (DIP); - a step of reception , from the card reader (LecC), of said piece of personal identification data (DIP). - a step of transmission , to a card reader (LecC) connected to the communications terminal (TC), of a request (RqP) for supporting the display of a virtual keypad (VK), said request (RqP) comprising a piece of data representing a passage of said communications terminal from a mode of operation called a "master" mode to a mode of operation called a "slave" mode, said second mode of operation leading to the implementation of said method for processing transaction data under the exclusive control of the card reader; - a step of entry , by said user on said virtual keypad (VK), of the piece of personal identification data (DIP); - a step of reception , from the card reader (LecC), of said piece of personal identification data (DIP).
A method of determining the extent of degradation of RNA in a sample, expressed as an RNA quality value, the method comprising: a) combining a sample suspected of containing RNA with a first nucleic acid binding dye that selectively binds small RNA comprising 200 nucleotides or less and a second nucleic acid binding dye that selectively binds intact RNA with secondary and/or tertiary structure, wherein the first nucleic acid binding dye and the second nucleic acid binding dye are detectably distinct; b) incubating the sample for a time period sufficient to allow the first nucleic acid binding dye and the second nucleic acid binding dye to combine with the RNA in the sample to form a first nucleic acid binding dye-RNA complex and a second nucleic acid binding dye-RNA complex; c) illuminating the first nucleic acid binding dye-RNA complex and the second nucleic acid binding dye-RNA complex with an appropriate wavelength of light to form an illuminated sample mixture, wherein the first nucleic acid binding dye-RNA complex emits a first fluorescent signal and the second nucleic acid binding dye-RNA complex emits a second fluorescent signal; d) detecting the first fluorescent signal and the second fluorescent signal; and e) calculating a ratio of the first fluorescent signal to the second fluorescent signal, thereby obtaining the RNA quality value, wherein the RNA quality value represents the extent of degradation of RNA in the sample, wherein the first nucleic acid binding dye is selected from and , wherein Ψ is a biologically compatible counterion and wherein the second nucleic acid binding dye is selected from: and a) combining a sample suspected of containing RNA with a first nucleic acid binding dye that selectively binds small RNA comprising 200 nucleotides or less and a second nucleic acid binding dye that selectively binds intact RNA with secondary and/or tertiary structure, wherein the first nucleic acid binding dye and the second nucleic acid binding dye are detectably distinct; b) incubating the sample for a time period sufficient to allow the first nucleic acid binding dye and the second nucleic acid binding dye to combine with the RNA in the sample to form a first nucleic acid binding dye-RNA complex and a second nucleic acid binding dye-RNA complex; c) illuminating the first nucleic acid binding dye-RNA complex and the second nucleic acid binding dye-RNA complex with an appropriate wavelength of light to form an illuminated sample mixture, wherein the first nucleic acid binding dye-RNA complex emits a first fluorescent signal and the second nucleic acid binding dye-RNA complex emits a second fluorescent signal; d) detecting the first fluorescent signal and the second fluorescent signal; and e) calculating a ratio of the first fluorescent signal to the second fluorescent signal, thereby obtaining the RNA quality value, wherein the RNA quality value represents the extent of degradation of RNA in the sample, wherein the first nucleic acid binding dye is selected from and , wherein Ψ is a biologically compatible counterion and wherein the second nucleic acid binding dye is selected from: and
A method for analyzing a sample containing at least one analyte, the method comprising: a) subjecting the sample to a first liquid chromatographic separation mode at a first pH with a first mobile phase; b) collecting at least one fraction from the first chromatographic separation; c) concentrating or diluting the at least one fraction; d) subjecting the diluted or concentrated at least one fraction to a second liquid chromatographic separation mode at a second pH with a second mobile phase; e) detecting the presence or absence of the at least one analyte in the sample; wherein the first pH and the second pH differ by at least 3 pH units and the first and second chromatographic separation modes are high performance liquid chromatography (HPLC). a) subjecting the sample to a first liquid chromatographic separation mode at a first pH with a first mobile phase; b) collecting at least one fraction from the first chromatographic separation; c) concentrating or diluting the at least one fraction; d) subjecting the diluted or concentrated at least one fraction to a second liquid chromatographic separation mode at a second pH with a second mobile phase; e) detecting the presence or absence of the at least one analyte in the sample;
A method, performed by a wireless communication network , for managing a problem with a first radio link between a wireless device and a serving network node comprised in the wireless communication network , wherein the method comprises: - sending (201a; 301, 401a; 501; 601), from a serving network node in connection with that the serving network node becomes serving network node for the wireless device and prior to the problem with the first radio link being detected, first information to the wireless device , said first information comprising a first identifier identifying the serving network node , and implicitly informing the wireless device that the first identifier, if received from a candidate network node (110; 111a; 111b), means that the serving network node has authorized setting up a working radio link (121; 122a; 122b), without said problem, between the wireless device and said candidate node (110; 111a; 111b), and wherein the first information further informs the wireless device that the first identifier, if received from said candidate network node (110; 111a; 111b), means that, a context of the first radio link is still valid and thus can be continued to be used for said working radio link (121; 122a; 122b) in the absence of any further signal from the serving network node to the wireless device . - sending (201a; 301, 401a; 501; 601), from a serving network node in connection with that the serving network node becomes serving network node for the wireless device and prior to the problem with the first radio link being detected, first information to the wireless device , said first information comprising a first identifier identifying the serving network node , and implicitly informing the wireless device that the first identifier, if received from a candidate network node (110; 111a; 111b), means that the serving network node has authorized setting up a working radio link (121; 122a; 122b), without said problem, between the wireless device and said candidate node (110; 111a; 111b), and wherein the first information further informs the wireless device that the first identifier, if received from said candidate network node (110; 111a; 111b), means that, a context of the first radio link is still valid and thus can be continued to be used for said working radio link (121; 122a; 122b) in the absence of any further signal from the serving network node to the wireless device .
A container comprising a lid part and a container part , wherein said container part comprises a bottom and connected to said bottom a circumferential container wall ending in a rim for receiving said lid part , said lid part being substantially made from a thermoplastic material and comprising a connection portion for connection to a rim of a container part and a lid which is pivotably connected to said connection portion , said connection portion comprising an upper wall provided with an access opening , which can be sealed with said lid and a circumferential first flange upstanding from the upper wall and surrounding said access opening , said lid comprising a circumferential lid flange extending towards said connection portion , perimeters of said lid flange and of said first flange mutually adapted to allow said lid flange to close in a sealing manner around an exterior of said first flange of said connection portion , wherein an area of said access opening is at least about 50 cm2 and said connection portion is provided with stacking provisions arranged around said access opening and which are complementary with stacking provisions at the bottom of said container part , whereby a first container may be stacked on the upper wall of a second container without loading the lid , said container further comprising a sealing foil attached to an inner surface of the container part and a space provided between the lid and the sealing foil for storing a measuring scoop.
An electrode assembly for electrically stimulating a user, the electrode assembly comprising: • a set of electrodes each comprising: o a hydrophilic material ; o a support structure retaining the hydrophilic material; o a conductive polymer substrate in electrical communication with the hydrophilic material ; and o an electrical coupler; • a compliant base configured to conform to a curvature of a forehead-region of the user during use, the compliant base retaining each of the set of electrodes in position and separating each of the set of electrodes from each other; and • an electronic coupling assembly coupled to the electrical coupler of each of the set of electrodes through the compliant base and configured to couple the set of electrodes to an electronics subsystem ; o wherein the electronic coupling assembly further comprises a first set of conductive polymer contacts , the first set of conductive polymer contacts electrically connected to a second set of conductive polymer contacts on the electronics subsystem ; and o wherein the first and second sets of conductive polymer contacts are vertically aligned along an inferior-superior axis. • a set of electrodes each comprising: o a hydrophilic material ; o a support structure retaining the hydrophilic material; o a conductive polymer substrate in electrical communication with the hydrophilic material ; and o an electrical coupler; o a hydrophilic material ; o a support structure retaining the hydrophilic material; o a conductive polymer substrate in electrical communication with the hydrophilic material ; and o an electrical coupler; • a compliant base configured to conform to a curvature of a forehead-region of the user during use, the compliant base retaining each of the set of electrodes in position and separating each of the set of electrodes from each other; and • an electronic coupling assembly coupled to the electrical coupler of each of the set of electrodes through the compliant base and configured to couple the set of electrodes to an electronics subsystem ; o wherein the electronic coupling assembly further comprises a first set of conductive polymer contacts , the first set of conductive polymer contacts electrically connected to a second set of conductive polymer contacts on the electronics subsystem ; and o wherein the first and second sets of conductive polymer contacts are vertically aligned along an inferior-superior axis. o wherein the electronic coupling assembly further comprises a first set of conductive polymer contacts , the first set of conductive polymer contacts electrically connected to a second set of conductive polymer contacts on the electronics subsystem ; and o wherein the first and second sets of conductive polymer contacts are vertically aligned along an inferior-superior axis.
An aerial photograph image pickup method comprising a step of making to fly meanderingly a flying object , which comprises a GPS device , a navigating means , an image pickup device for taking an image downward, an image processing unit and a main arithmetic control unit , characterised in that said method further comprises a step of taking an image with said image pickup device at each vertex where a direction is changed in the meandering flight, a step of extracting feature points from a common overlap portion of the images taken at three vertexes adjacent to each other, a step of determining two sets of two images adjacent to each other from the images taken at said three vertexes and acquiring positional information of said two vertexes by said GPS device for each set, a step of performing photogrammetry of measuring points corresponding to said feature points based on the positional information and based on said feature points of said two images on each set, a step of setting said feature points when surveying results of said measuring points coincide with each other in said two sets as tie points for image combination, and a step of carrying out, based on said tie points and three-dimensional coordinates of said three vertexes measured by said GPS device, a local processing of a calculation of photographing positions of the images taken at said three vertexes and an orientation calculation of tilting.
A gas sensor comprising: a base member including, a semiconductor substrate formed with an opening portion extending in a thickness direction, an insulating layer which is formed on the semiconductor substrate and which includes a separating wall portion formed at a position confronting the opening portion, a heat generating resistor formed on the partition wall portion, and a protection layer formed on the insulating layer to cover the heat generating resistor; a gas sensing layer which is formed on the protection layer of the base member and which includes, as a main component, a metal oxide semiconductor having an electric characteristic varied in accordance with variation of a concentration of a specific gas in a measurement gas; a pair of sensing electrodes formed on the protection layer of the base member and arranged to sense variation of the electric characteristic of the gas sensing layer ; and an adhesion layer which is formed on the protection layer of the base member and which contacts with the gas sensing layer ; characterized in that the sensing electrodes are in contact with the gas sensing layer but not in contact with the adhesion layer , and the adhesion layer is formed continuously between the sensing electrodes and around the sensing electrodes . a base member including, a semiconductor substrate formed with an opening portion extending in a thickness direction, an insulating layer which is formed on the semiconductor substrate and which includes a separating wall portion formed at a position confronting the opening portion, a heat generating resistor formed on the partition wall portion, and a protection layer formed on the insulating layer to cover the heat generating resistor; a gas sensing layer which is formed on the protection layer of the base member and which includes, as a main component, a metal oxide semiconductor having an electric characteristic varied in accordance with variation of a concentration of a specific gas in a measurement gas; a pair of sensing electrodes formed on the protection layer of the base member and arranged to sense variation of the electric characteristic of the gas sensing layer ; and an adhesion layer which is formed on the protection layer of the base member and which contacts with the gas sensing layer ;
A wing locking system for a harvesting header comprising: an accumulator ; a fluid cylinder configured to be operably attached to a wing of the harvesting header ; a hose fluidly connecting the accumulator and the fluid cylinder ; and a valve operably disposed between the accumulator and the fluid cylinder , the valve having a first selectable position configured to permit a first fluid flow rate between the accumulator and the fluid cylinder and a second selectable position, characterized in that the valve is in the second position configured to permit a second fluid flow rate from the accumulator to the fluid cylinder ; the first fluid flow rate being greater than the second fluid flow rate; that the second selectable position of the valve permits fluid flow from the accumulator to the fluid cylinder through an orificed check valve , that when the valve is in the second selectable position, the flow of fluid into the fluid cylinder is configured to constrain an upward pivot angle of the wing and that the valve is configured to be in the second selectable position when the harvesting header encounters a negative loading condition. an accumulator ; a fluid cylinder configured to be operably attached to a wing of the harvesting header ; a hose fluidly connecting the accumulator and the fluid cylinder ; and a valve operably disposed between the accumulator and the fluid cylinder , the valve having a first selectable position configured to permit a first fluid flow rate between the accumulator and the fluid cylinder and a second selectable position, characterized in that the valve is in the second position configured to permit a second fluid flow rate from the accumulator to the fluid cylinder ; the first fluid flow rate being greater than the second fluid flow rate; that the second selectable position of the valve permits fluid flow from the accumulator to the fluid cylinder through an orificed check valve , that when the valve is in the second selectable position, the flow of fluid into the fluid cylinder is configured to constrain an upward pivot angle of the wing and that the valve is configured to be in the second selectable position when the harvesting header encounters a negative loading condition.
A method for producing purified water comprising a step of passing water through a mixed bed ion exchanger consisting of a mixture of anion exchange particles and cation exchange particles, wherein the mean particle diameter of the beads of the mixed bed ion exchanger is less than 0.5 mm, and the anion exchange beads and the cation exchange beads are monodisperse, respectively, characterized in that the water is further passed through an ultrafiltration means with a cut-off at 5 kDa or larger, wherein the ultrafiltration means is located upstream of said mixed bed ion exchanger, and characterized in that the method comprises a further step of passing water through an activated carbon bed located downstream of the ultrafiltration means and optionally downstream of the mixed bed ion exchanger.
An isolated cell comprising an exogenous nucleic acid sequence integrated within a locus of the genome of the cell, wherein the locus comprises a nucleotide sequence that is: (a) at least 90% identical to SEQ ID NO:1 or SEQ ID NO: 4, and (b) capable of enhancing expression of a protein encoded by an exogenous nucleic acid sequence by at least 1.5-fold compared to expression typically observed by random integration into the genome. (a) at least 90% identical to SEQ ID NO:1 or SEQ ID NO: 4, and (b) capable of enhancing expression of a protein encoded by an exogenous nucleic acid sequence by at least 1.5-fold compared to expression typically observed by random integration into the genome.