mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: A 1 represents N or CR 2A , A 2 represents N or CR 2B and A 3 represents N or CR 2C , where no more than one of A 1 , A 2 and A 3 represent N; R 1 represents C 4-6 cycloalkyl or a 4 to 6 membered heterocycloalkyl containing one heteroatom selected from O, S and N, wherein the C 4-6 cycloalkyl or 4 to 6 membered heterocycloalkyl is optionally substituted with one or more groups selected from fluoro, C 1-3 alkyl (optionally substituted with a group selected from hydroxyl and C 1-2 alkoxy), cyclopropyl, hydroxyl, NH 2 , dioxo, C(O)C 1-2 alkyl, azetidinyl and oxetanyl; R 2A , R 2B and R 2C each independently represent hydrogen, methyl or methoxy. A 1 represents N or CR 2A , A 2 represents N or CR 2B and A 3 represents N or CR 2C , where no more than one of A 1 , A 2 and A 3 represent N; R 1 represents C 4-6 cycloalkyl or a 4 to 6 membered heterocycloalkyl containing one heteroatom selected from O, S and N, wherein the C 4-6 cycloalkyl or 4 to 6 membered heterocycloalkyl is optionally substituted with one or more groups selected from fluoro, C 1-3 alkyl (optionally substituted with a group selected from hydroxyl and C 1-2 alkoxy), cyclopropyl, hydroxyl, NH 2 , dioxo, C(O)C 1-2 alkyl, azetidinyl and oxetanyl; R 2A , R 2B and R 2C each independently represent hydrogen, methyl or methoxy.
Nivolumab for use in a method of treating newly diagnosed classical Hodgkin lymphoma in a subject in need thereof, wherein the subject is previously untreated except with corticosteroid; and wherein the subject is to be administered nivolumab alone at a flat dose of 240 mg every 2 weeks for 4 doses and then at a flat dose of 240 mg in combination with doxorubicin, vinblastine, and dacarbazine about every 2 weeks for 6 combo-cycles, wherein the doxorubicin is to be administered at a dose of 25 mg/m 2 , the vinblastine is to be administered at a dose of 6 mg/m 2 , and the dacarbazine is to be administered at a dose of 375 mg/m 2
A powder core comprising: a compact including a soft magnetic powder (MM) and a binding component; and an outer coating of the compact , wherein the binding component is composed of a pyrolysis residue (TDM) of a binder component (BM) containing a resin-based material; wherein the compact comprises voids (PR), wherein a material (CRM) constituting the outer coating contains polyethersulfone and is located so as to fill at least part of the voids (PR), and wherein the outer coating is obtained by drying a liquid composition containing polyethersulfone and a solvent, a concentration of polyehtersulfone being 1 mass% or more and 40 mass% or less. a compact including a soft magnetic powder (MM) and a binding component; and an outer coating of the compact , wherein the binding component is composed of a pyrolysis residue (TDM) of a binder component (BM) containing a resin-based material; wherein the compact comprises voids (PR), wherein a material (CRM) constituting the outer coating contains polyethersulfone and is located so as to fill at least part of the voids (PR), and wherein the outer coating is obtained by drying a liquid composition containing polyethersulfone and a solvent, a concentration of polyehtersulfone being 1 mass% or more and 40 mass% or less.
A communication method, comprising: receiving (S302), by a first terminal, a first electronic business card by a first electronic business card push message sent by a second terminal, wherein the first electronic business card is an electronic business card of a user corresponding to a client of a third terminal or a client of the second terminal; and displaying, by the first terminal, a first identifier based on the first electronic business card, but skipping displaying a first user account meaning that the first terminal can display only the first identifier based on the first electronic business card and cannot display the first user account indicated by the first identifier, wherein the first user account is an account of the user corresponding to the first electronic business card, and the first identifier is used to identify the first user account, wherein the first identifier is obtained from a server that allocates, to each user account, an identifier that uniquely identifies the respective user account, wherein the first terminal cannot directly communicate, based on the first identifier, with a terminal of the user corresponding to the first user account, and instead, obtains the first user account based on the first identifier, to communicate with the terminal of the user corresponding to the first user account. receiving (S302), by a first terminal, a first electronic business card by a first electronic business card push message sent by a second terminal, wherein the first electronic business card is an electronic business card of a user corresponding to a client of a third terminal or a client of the second terminal; and displaying, by the first terminal, a first identifier based on the first electronic business card, but skipping displaying a first user account meaning that the first terminal can display only the first identifier based on the first electronic business card and cannot display the first user account indicated by the first identifier, wherein the first user account is an account of the user corresponding to the first electronic business card, and the first identifier is used to identify the first user account, wherein the first identifier is obtained from a server that allocates, to each user account, an identifier that uniquely identifies the respective user account, wherein the first terminal cannot directly communicate, based on the first identifier, with a terminal of the user corresponding to the first user account, and instead, obtains the first user account based on the first identifier, to communicate with the terminal of the user corresponding to the first user account.
A refrigerant for a cooling device having a cooling circuit comprising at least one heat exchanger in which the refrigerant undergoes a phase transition, the refrigerant being a refrigerant mixture composed of one part carbon dioxide (CO 2 ), one part difluoromethane (CH 2 F 2 ), and one part 1,1,1,2-tetrafluoroethane (C 2 H 2 F 4 ), the part 1,1,1,2-tetrafluoroethane being (1 to 29) mole percent characterized in that the part carbon dioxide in the refrigerant mixture is (54 to 81) mole percent, the part difluoromethane being (10 to 20) mole percent.
The use of a combination of: a. at least one hydrocarbyl-substituted aromatic compound; and b. at least one polyalkylene amine, for improving the valve deposit formation control performance of a fuel composition in a direct injection spark-ignition internal combustion engine; wherein the valve is an air intake valve, an exhaust valve or an exhaust gas recirculation valve, wherein the at least one hydrocarbyl-substituted aromatic compound is a Mannich Base detergent. a. at least one hydrocarbyl-substituted aromatic compound; and b. at least one polyalkylene amine,
A method, comprising: imaging a region of interest with an x-ray source and a segmented photon-counting detector array ; detecting a position of an object of interest in the region of interest; selectively scanning, via the x-ray source and the segmented photon-counting detector array, the object of interest; detecting a coherent scatter signal from the object of interest with the segmented photon-counting detector array; and determining a material comprising the object of interest based on the detected coherent scatter signal, wherein selectively scanning the object of interest comprises collimating the x-ray source and adjusting a position of the x-ray source, the segmented photon-counting detector array, and the object of interest to illuminate a single slice of a volume in the region of interest containing the object of interest, and wherein adjusting the position of the x-ray source, the segmented photon-counting detector array, and the object of interest maximizes separation of the coherent scatter signal from a primary x-ray beam on the segmented photon-counting detector array. imaging a region of interest with an x-ray source and a segmented photon-counting detector array ; detecting a position of an object of interest in the region of interest; selectively scanning, via the x-ray source and the segmented photon-counting detector array, the object of interest; detecting a coherent scatter signal from the object of interest with the segmented photon-counting detector array; and determining a material comprising the object of interest based on the detected coherent scatter signal, wherein selectively scanning the object of interest comprises collimating the x-ray source and adjusting a position of the x-ray source, the segmented photon-counting detector array, and the object of interest to illuminate a single slice of a volume in the region of interest containing the object of interest, and wherein adjusting the position of the x-ray source, the segmented photon-counting detector array, and the object of interest maximizes separation of the coherent scatter signal from a primary x-ray beam on the segmented photon-counting detector array.
A trolley case comprises an upper cover and a lower cover which is openable and connectable to the upper cover , an inner side of the upper cover is provided continuously or intermittently with an upper reinforcing strip , an inner part of the upper reinforcing strip is a first hollow structure, the upper reinforcing strip is defined at an inner periphery of a side of the upper cover adjacent to the lower cover ; an inner side of the lower cover is provided continuously or intermittently with a lower reinforcing strip , an inner part of the lower reinforcing strip is a second hollow structure, the lower reinforcing strip is defined at an inner periphery of a side of the lower cover adjacent to the upper cover ; the upper reinforcing strip and the lower reinforcing strip form a support region (S) for preventing deformation of the upper cover and the lower cover and co-supporting the trolley case when the upper cover and the lower cover are closed; wherein the upper cover comprises an upper cover side surface and an upper cover surface (S1), the lower cover comprises a lower cover side surface and a lower cover surface (S2), an edge of the upper cover adjacent to the lower cover protrudes outwardly to form a first buffer step , the first buffer step comprises a first buffer surface and a first reinforcement surface , one end of the first buffer surface is defined at the edge of the upper cover close to the lower cover , the other end of the first buffer surface extends in a direction opposite to the lower cover and is connected to the first reinforcing surface , a part of the first reinforcing surface is recessed along the upper cover side surface to form a first inner groove, the upper reinforcing strip is defined in the first inner groove; an edge of the lower cover adjacent to the upper cover protrudes outwardly to form a second buffer step , the second buffer step comprises a second buffer surface and a second reinforcement surface , one end of the second buffer surface is defined at the edge of the lower cover close to the upper cover , the other end of the second buffer surface extends in a direction opposite to the upper cover and is connected to the second reinforcing surface , a part of the second reinforcing surface is recessed along the lower cover side surface to form a second inner groove , the lower reinforcing strip is defined in the second inner groove ; a height of the first inner groove is smaller than or equal to a height of the first buffer surface , a thickness of the first buffer surface is larger than a thickness of the upper cover side surface ; a recessed height of the second inner groove is smaller than or equal to a height (H2) of the second buffer surface , a thickness (D) of the second buffer surface is larger than a thickness (d) of the lower cover side surface ; when the upper cover and the lower cover are closed, the first buffer surface is abutted against the second buffer surface to form the support region (S).
A mobile microwave system for controlling weed growth in a target location, such as an agricultural field, the system comprising - a microwave unit comprising a microwave generator for generating microwaves within a frequency range suitable for controlling weed growth; - wherein the mobile microwave system is mountable to a vehicle or comprises a drive means for moving said mobile microwave system ; characterised in that the mobile microwave system further comprises: - a phased array antenna system comprising - a plurality of antenna elements for emitting a focused microwave beam within a target area; - at least one controllable phase shifter coupled between the microwave unit and the plurality of antenna elements ; - wherein the phase shifter is configured for shifting a microwave phase of at least a part of the generated microwaves in order to adjust a direction of the focused microwave beam; - and a processing unit operatively connected to the phase shifter and configured to steer the focused microwave beam direction to align the target area with a position of a target weed plant in the target location. - a microwave unit comprising a microwave generator for generating microwaves within a frequency range suitable for controlling weed growth; - wherein the mobile microwave system is mountable to a vehicle or comprises a drive means for moving said mobile microwave system ; - a phased array antenna system comprising - a plurality of antenna elements for emitting a focused microwave beam within a target area; - at least one controllable phase shifter coupled between the microwave unit and the plurality of antenna elements ; - wherein the phase shifter is configured for shifting a microwave phase of at least a part of the generated microwaves in order to adjust a direction of the focused microwave beam; - a plurality of antenna elements for emitting a focused microwave beam within a target area; - at least one controllable phase shifter coupled between the microwave unit and the plurality of antenna elements ; - wherein the phase shifter is configured for shifting a microwave phase of at least a part of the generated microwaves in order to adjust a direction of the focused microwave beam; - and a processing unit operatively connected to the phase shifter and configured to steer the focused microwave beam direction to align the target area with a position of a target weed plant in the target location.
A method for acquiring information of a target polypeptide, comprising: acquiring a diffusion time of a fluorescently labelled target polypeptide and a diffusion time of each of a plurality of fluorescently labelled reference polypeptides by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy, and acquiring information on size of the fluorescently labelled target polypeptide from the diffusion time of the fluorescently labelled target polypeptide with reference to the diffusion times of the plurality of fluorescently labelled reference polypeptides, wherein information on size of each of the plurality of fluorescently labelled reference polypeptides is known, and the sizes of the plurality of reference polypeptides are different from each other. acquiring a diffusion time of a fluorescently labelled target polypeptide and a diffusion time of each of a plurality of fluorescently labelled reference polypeptides by fluorescence correlation spectroscopy or fluorescence cross-correlation spectroscopy, and acquiring information on size of the fluorescently labelled target polypeptide from the diffusion time of the fluorescently labelled target polypeptide with reference to the diffusion times of the plurality of fluorescently labelled reference polypeptides, wherein information on size of each of the plurality of fluorescently labelled reference polypeptides is known, and the sizes of the plurality of reference polypeptides are different from each other.
A method for the in-situ production of a molecular complex microarray comprising the following steps: a) Providing a first surface comprising a plurality of separate active regions, b) Introduction of first molecules into a plurality of active regions, c) Fixing the presented molecules onto the surface, d) Adding a second molecule to each active region with the first molecule present, e) Closing the active regions with a second surface, f) Complexation between the molecules, g) Immobilization of the formed complex on a capture surface. a) Providing a first surface comprising a plurality of separate active regions, b) Introduction of first molecules into a plurality of active regions, c) Fixing the presented molecules onto the surface, d) Adding a second molecule to each active region with the first molecule present, e) Closing the active regions with a second surface, f) Complexation between the molecules, g) Immobilization of the formed complex on a capture surface.
An apparatus for carrying out a selected fluid management and/or renal replacement patient therapy comprising: a control unit having a blood pump and a plurality of fluid pumps mounted thereon, and comprising a controller configured for operating said blood pump and said fluid pumps , and an interactive operator control system including an operator interface screen operatively connected to said controller, said controller including software configured to operate said apparatus in response to operator input selections; and wherein said apparatus is characterized by a replaceable panel kit having three separate panels configured to be manually mounted on and manually removed from said control unit comprising a blood panel having blood supply tubing mounted and secured thereon, a fluid panel having fluid supply tubing mounted and secured thereon, and a filter cartridge panel secured to said blood panel and said fluid panel , said filter cartridge panel having a replaceable filter cartridge mounted thereon; and wherein said interactive operator control system is characterized by operator inputs for selectively changing the replaceable panel kit, replacing the filter cartridge without changing the panel kit, and changing to a different patient therapy from a currently running patient therapy, and providing operator instructions for carrying out the aforesaid. a control unit having a blood pump and a plurality of fluid pumps mounted thereon, and comprising a controller configured for operating said blood pump and said fluid pumps , and an interactive operator control system including an operator interface screen operatively connected to said controller, said controller including software configured to operate said apparatus in response to operator input selections; and wherein said apparatus is characterized by a replaceable panel kit having three separate panels configured to be manually mounted on and manually removed from said control unit comprising a blood panel having blood supply tubing mounted and secured thereon, a fluid panel having fluid supply tubing mounted and secured thereon, and a filter cartridge panel secured to said blood panel and said fluid panel , said filter cartridge panel having a replaceable filter cartridge mounted thereon; and wherein said interactive operator control system is characterized by operator inputs for selectively changing the replaceable panel kit, replacing the filter cartridge without changing the panel kit, and changing to a different patient therapy from a currently running patient therapy, and providing operator instructions for carrying out the aforesaid.
Acoustic wave device comprising: - a substrate surmounted with an acoustic mirror, - an acoustic mirror constituted by a stack of a given pair of materials in alternate layers with high and low acoustic impedance, - a piezoelectric layer arranged above the acoustic mirror, and - excitation and/or receiving means constituted by interdigitated conductor combs on a surface of said piezoelectric layer, characterised in that the acoustic wave device additionally comprises the acoustic mirror having a pitch, corresponding to the sum of the thicknesses of a layer of each material of the given pair of materials, which is configured to render the acoustic mirror omnidirectional, reflecting in a frequency range the waves of all incidences, the excitation and/or receiving means being capable of exciting waves in said frequency range corresponding to a band gap of the acoustic mirror where no propagation mode is possible whatever the wavelength, the piezoelectric layer having a layer thickness determined as a function of said frequency range in which said piezoelectric layer is capable of vibrating while guiding the acoustic waves excited by the excitation and/or receiving means . - a substrate surmounted with an acoustic mirror, - an acoustic mirror constituted by a stack of a given pair of materials in alternate layers with high and low acoustic impedance, - a piezoelectric layer arranged above the acoustic mirror, and - excitation and/or receiving means constituted by interdigitated conductor combs on a surface of said piezoelectric layer,
An intracardiac ventricular pacemaker, comprising: a pulse generator configured to generate and deliver pacing pulses to a ventricle of a patient's heart via electrodes coupled to the pacemaker; a motion sensor configured to produce a motion signal comprising a ventricular diastolic event and an atrial systolic event; and characterised by a control circuit coupled to the motion sensor and the pulse generator and configured to: detect the ventricular diastolic event from the motion signal; start an atrial refractory period having an expiration time set based on a time of the detection of the ventricular diastolic event; detect a first atrial systolic event from the motion signal after expiration of the atrial refractory period; and control the pulse generator to deliver a first pacing pulse to the ventricle at a first atrioventricular pacing time interval after the first atrial systolic event detection. a pulse generator configured to generate and deliver pacing pulses to a ventricle of a patient's heart via electrodes coupled to the pacemaker; a motion sensor configured to produce a motion signal comprising a ventricular diastolic event and an atrial systolic event; and characterised by a control circuit coupled to the motion sensor and the pulse generator and configured to: detect the ventricular diastolic event from the motion signal; start an atrial refractory period having an expiration time set based on a time of the detection of the ventricular diastolic event; detect a first atrial systolic event from the motion signal after expiration of the atrial refractory period; and control the pulse generator to deliver a first pacing pulse to the ventricle at a first atrioventricular pacing time interval after the first atrial systolic event detection. detect the ventricular diastolic event from the motion signal; start an atrial refractory period having an expiration time set based on a time of the detection of the ventricular diastolic event; detect a first atrial systolic event from the motion signal after expiration of the atrial refractory period; and control the pulse generator to deliver a first pacing pulse to the ventricle at a first atrioventricular pacing time interval after the first atrial systolic event detection.