mhurhangee/patent-ind-claim-en huggingface dataset:
A surgical kit comprising a surgical instrument including a handle portion , and an instrument shaft (10, 10', 10", 10′′′) having a first end , a second end , a longitudinal axis (L) extending from the first end to the second end and a channel extending completely through the instrument shaft from the first end to the second end; wherein the instrument shaft (10, 10', 10", 10′′′) is configured to be releasably connectable to the handle portion ; and a secondary instrument configured to be inserted into the channel and configured to extend out of the channel with a portion thereof in the inserted state; and wherein the surgical kit further comprises at least two different instrument shafts (10, 10', 10", 10′′′) having two different functional sections that differ in their function or that have the same function but different geometrical and/or mechanical or other characteristics, wherein the at least two instrument shafts can be connected interchangeably to the handle portion. a handle portion , and an instrument shaft (10, 10', 10", 10′′′) having a first end , a second end , a longitudinal axis (L) extending from the first end to the second end and a channel extending completely through the instrument shaft from the first end to the second end; wherein the instrument shaft (10, 10', 10", 10′′′) is configured to be releasably connectable to the handle portion ; and a secondary instrument configured to be inserted into the channel and configured to extend out of the channel with a portion thereof in the inserted state; and wherein the surgical kit further comprises at least two different instrument shafts (10, 10', 10", 10′′′) having two different functional sections that differ in their function or that have the same function but different geometrical and/or mechanical or other characteristics, wherein the at least two instrument shafts can be connected interchangeably to the handle portion.
An apparatus to recover an aircraft , the apparatus comprising a kite ; a tether line to be supported by the kite at a distal end thereof; and a parafoil , the tether line carrying the parafoil; a release device configured to deploy the parafoil from the tether line in response to the aircraft contacting the tether line , wherein the kite is configured to change its shape to a trailing edge drag device in response to the parafoil being deployed. a tether line to be supported by the kite at a distal end thereof; and a parafoil , the tether line carrying the parafoil; a release device configured to deploy the parafoil from the tether line in response to the aircraft contacting the tether line , wherein the kite is configured to change its shape to a trailing edge drag device in response to the parafoil being deployed.
A nucleic acid probe comprising: an oligonucleotide having the structure 5'-Y 1 -L 1 -L Q1 -L 2 -Y 2 -3', wherein Y 1 comprises a sequence of two or more DNA or RNA nucleotides; Y 2 comprises a sequence of two or more DNA or RNA nucleotides; wherein one of Y 1 and Y 2 has a fluorophore covalently attached (directly or through a linker) to its nucleotide sequence, and the other of Y 1 and Y 2 has a second quencher covalently attached (directly or through a linker) to its nucleotide sequence; L 1 and L 2 are independently selected from a bond, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted heterocycloalkyl; and L Q1 is wherein Q 1 is a first quencher having a structure: wherein: R b2 and R c2 are independently methyl or ethyl or n-propyl or isopropyl or n-butyl or isobutyl or sec -butyl or tert -butyl; R c4 is H; and L 3 is a bond. Y 1 comprises a sequence of two or more DNA or RNA nucleotides; Y 2 comprises a sequence of two or more DNA or RNA nucleotides; wherein one of Y 1 and Y 2 has a fluorophore covalently attached (directly or through a linker) to its nucleotide sequence, and the other of Y 1 and Y 2 has a second quencher covalently attached (directly or through a linker) to its nucleotide sequence; L 1 and L 2 are independently selected from a bond, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted heterocycloalkyl; and L Q1 is wherein Q 1 is a first quencher having a structure: wherein: R b2 and R c2 are independently methyl or ethyl or n-propyl or isopropyl or n-butyl or isobutyl or sec -butyl or tert -butyl; R c4 is H; and L 3 is a bond. wherein Q 1 is a first quencher having a structure: wherein: R b2 and R c2 are independently methyl or ethyl or n-propyl or isopropyl or n-butyl or isobutyl or sec -butyl or tert -butyl; R c4 is H; and L 3 is a bond. R b2 and R c2 are independently methyl or ethyl or n-propyl or isopropyl or n-butyl or isobutyl or sec -butyl or tert -butyl; R c4 is H; and L 3 is a bond.
A method for generating a cryptographic key for an electronic, cable-based communication between a first user and a second user, wherein the method comprises the following steps: - measuring a transmission function, respectively, or determining a variable, derived from the measured transmission function, between the first and the second user, respectively, by the first and the second user, - quantizing the respective transmission function or the variable derived therefrom, so that respectively quantized values of the transmission function or the derived variable are present, and - respective assigning of a bit pattern to the quantized values of the respective transmission function or the derived variable, wherein the bit pattern forms at least a part of the respective cryptographic key and the transmission function is actively changed randomly, so that a cryptographic key is generated at the two communicating users, without the key itself having to be transmitted and without a third party being able to acquire the key. - measuring a transmission function, respectively, or determining a variable, derived from the measured transmission function, between the first and the second user, respectively, by the first and the second user, - quantizing the respective transmission function or the variable derived therefrom, so that respectively quantized values of the transmission function or the derived variable are present, and - respective assigning of a bit pattern to the quantized values of the respective transmission function or the derived variable, wherein the bit pattern forms at least a part of the respective cryptographic key and the transmission function is actively changed randomly, so that a cryptographic key is generated at the two communicating users, without the key itself having to be transmitted and without a third party being able to acquire the key.
A process for producing carbon fibers comprising: spinning a polyacrylonitrile polymer solution having a concentration of 19% to 24% polymer in a coagulation bath at a coagulation bath concentration of 70% to 85% by weight of dimethyl sulfoxide and 15% to 30% by weight of water, and at a coagulation bath temperature of between 0°C and 10°C, thereby forming carbon fiber precursor fibers; drawing the carbon fiber precursor fibers exiting from coagulation bath through one or more draw and wash baths in order to stretch and remove solvent from the fibers, wherein the carbon fiber precursor fibers have about 500 ppm or less of solvent after the step of drawing the carbon fiber precursor fibers; and stabilizing and carbonizing the carbon fiber precursor fibers; wherein the carbon fiber precursor fibers from the coagulation bath have a degree of swelling of from 80% to 120%, and an average pore diameter of 0.01 μm to 0.03 μm with a porosity of 30% to 70%, and wherein the carbon fiber precursor fibers are carbonized at a temperature of from 1100°C to 1500°C; wherein the degree of swelling is measured as described in the description and the average pore diameter as well as the porosity are measured as described in the description. spinning a polyacrylonitrile polymer solution having a concentration of 19% to 24% polymer in a coagulation bath at a coagulation bath concentration of 70% to 85% by weight of dimethyl sulfoxide and 15% to 30% by weight of water, and at a coagulation bath temperature of between 0°C and 10°C, thereby forming carbon fiber precursor fibers; drawing the carbon fiber precursor fibers exiting from coagulation bath through one or more draw and wash baths in order to stretch and remove solvent from the fibers, wherein the carbon fiber precursor fibers have about 500 ppm or less of solvent after the step of drawing the carbon fiber precursor fibers; and stabilizing and carbonizing the carbon fiber precursor fibers; wherein the carbon fiber precursor fibers from the coagulation bath have a degree of swelling of from 80% to 120%, and an average pore diameter of 0.01 μm to 0.03 μm with a porosity of 30% to 70%, and wherein the carbon fiber precursor fibers are carbonized at a temperature of from 1100°C to 1500°C; wherein the degree of swelling is measured as described in the description and the average pore diameter as well as the porosity are measured as described in the description.
A kit for providing a sterile injectable botulinum toxin for administration by injection to achieve a therapeutic or cosmetic effect in a subject in need thereof, the kit comprising: a botulinum toxin component present in an amount suitable for injection, the botulinum toxin component selected from the group consisting of a botulinum toxin complex, reduced botulinum toxin complex, and botulinum toxin; a positively charged carrier comprising the amino acid sequence RKKRRQRRRG-(K) 15 -GRKKRRQRRR, wherein the positively charged carrier non-covalently associates with the botulinum toxin component; and a pharmaceutically acceptable diluent suitable for injection; wherein the botulinum toxin component and the positively charged carrier are provided separately from said pharmaceutically acceptable diluent in said kit. a botulinum toxin component present in an amount suitable for injection, the botulinum toxin component selected from the group consisting of a botulinum toxin complex, reduced botulinum toxin complex, and botulinum toxin; a positively charged carrier comprising the amino acid sequence RKKRRQRRRG-(K) 15 -GRKKRRQRRR, wherein the positively charged carrier non-covalently associates with the botulinum toxin component; and a pharmaceutically acceptable diluent suitable for injection; wherein the botulinum toxin component and the positively charged carrier are provided separately from said pharmaceutically acceptable diluent in said kit.
A B cell maturation agent (BCMA) binding trispecific protein comprising an amino acid sequence of SEQ ID NO: 520.
An ostomy pouch, comprising: an outer wall; a bodyside wall, wherein the outer wall and the bodyside wall are sealed along their peripheral edges to define a cavity; and wherein the bodyside wall is formed of a multilayer film including at least one foam layer, wherein the at least one foam layer includes an outer foam layer, wherein at least one of the foam layers comprises a vinyl-bond rich triblock copolymer, and wherein the outer foam layer is in contact with user's skin when the ostomy pouch is attached to the user. an outer wall; a bodyside wall, wherein the outer wall and the bodyside wall are sealed along their peripheral edges to define a cavity; and wherein the bodyside wall is formed of a multilayer film including at least one foam layer, wherein the at least one foam layer includes an outer foam layer, wherein at least one of the foam layers comprises a vinyl-bond rich triblock copolymer, and wherein the outer foam layer is in contact with user's skin when the ostomy pouch is attached to the user.
A part made of composite material comprising at least: - fiber reinforcement comprising silicon carbide fibers presenting an oxygen content less than or equal to 1% in atomic percentage; and - a matrix present in the pores of the fiber reinforcement and constituted for at least 50% by weight by a mixture of mullite with at least one rare earth silicate, the matrix occupying more than 50% of the volume of the accessible porosity of the fiber reinforcement, the matrix comprising at least a first sintered silicate phase comprising mullite and a second sintered silicate phase, different from the first phase, comprising at least one rare earth silicate. - fiber reinforcement comprising silicon carbide fibers presenting an oxygen content less than or equal to 1% in atomic percentage; and - a matrix present in the pores of the fiber reinforcement and constituted for at least 50% by weight by a mixture of mullite with at least one rare earth silicate, the matrix occupying more than 50% of the volume of the accessible porosity of the fiber reinforcement, the matrix comprising at least a first sintered silicate phase comprising mullite and a second sintered silicate phase, different from the first phase, comprising at least one rare earth silicate.
A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of: N-[cis-3-({[3-(difluoromethyl)azetidin-1-yl]sulfonyl}methyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-[cis-3-({[3-(2,2-difluoroethyl)-azetidin-1-yl]sulfonyl}methyl)-cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-( -3-(((3-(difluoromethoxy)azetidin-1-yl)sulfonyl)methyl)cyclobutyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-methyl-N-( -3-(((3-(trifluoromethyl)azetidin-1-yl)sulfonyl)methyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-( -3-(((3,3-difluoroazetidin-1-yl)sulfonyl)methyl)cyclobutyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; and, N-methyl-N-( -3-(((3,3,3-trifluoropropyl)sulfonyl)methyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. N-[cis-3-({[3-(difluoromethyl)azetidin-1-yl]sulfonyl}methyl)cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-[cis-3-({[3-(2,2-difluoroethyl)-azetidin-1-yl]sulfonyl}methyl)-cyclobutyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-( -3-(((3-(difluoromethoxy)azetidin-1-yl)sulfonyl)methyl)cyclobutyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-methyl-N-( -3-(((3-(trifluoromethyl)azetidin-1-yl)sulfonyl)methyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; N-( -3-(((3,3-difluoroazetidin-1-yl)sulfonyl)methyl)cyclobutyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; and, N-methyl-N-( -3-(((3,3,3-trifluoropropyl)sulfonyl)methyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.
An agent capable of stimulating directly the 5-hydroxytryptamine 1B receptor (5-HT1 BR), for use in a method for enhancing the in vivo engraftment potential of a biological material, comprising at least the step of in vitro and / or ex vivo contacting an isolated biological material with at least one said active agent capable of stimulating directly the 5-hydroxytryptamine 1B receptor (5-HT1 BR).
A method for dielectrically insulating an electrical active part wherein the electrical active part is arranged in a gas-tight housing comprising an insulating medium consisting of, consisting essentially of, or comprising a compound of general formula (I): NC-C n H m F -m -O-C n' H m' F (2n'+1)-m' (I) wherein n is 1, 2, 3, 4, or 5 and m is integer between 0 and 2n and wherein n' is 1, 2, 3, 4, or 5 and m' is integer between 0 and 2n' .
Timepiece mechanism comprising a rotating wheel set , a support element, a member (15a, 15b; 115a, 115b) mounted to pivot on the support element and return means for returning a portion of the pivoting member towards a surface of the rotating wheel set, said return means being formed by a first magnet (21; 121) carried by the pivoting member and a second magnet (25; 125) carried by the support element separately from the pivoting member, the first magnet and the second magnet being arranged such that, when the timepiece mechanism is in operation, these first and second magnets are in a first relative configuration, referred to as an operating configuration of the timepiece mechanism, wherein the interaction of the respective magnetic fields thereof generates a first magnetic force acting on the pivoting member which is oriented so as to exert thereon a return torque and thus return said portion of the pivoting member towards said surface of the rotating wheel set, characterized in that at least one of said first and second magnets is arranged to allow a clock to change the direction of its polarity independently of the angular position of the pivoting member, such that the first magnet and the second magnet are thus in a second relative configuration, referred to as an assembly or disassembly configuration of the timepiece mechanism, wherein a second magnetic force, generated between these first and second magnets, acts on the pivoting member so as to exert thereon a torque in the opposite direction to that of said return torque and thus keep said portion of the pivoting member distant from said surface of the rotating wheel set.
A roof system comprising: i. a roof substrate; ii. a first membrane including first and second opposed planar surfaces, where the first planar surface includes a roof-substrate contacting portion and a lap portion, said first membrane having disposed on said roof-substrate contacting portion and said lap portion a UV-cured adhesive, where said first membrane is adhered to said roof substrate through said adhesive disposed on said roof-substrate contacting portion where the UV-cured adhesive disposed on said first membrane has a substantially consistent degree of cure; and iii. a second membrane including opposed first and second planar surfaces, where the first planar surface includes a roof-substrate contacting portion and a lap portion, said second membrane having disposed on said roof-substrate contacting portion and said lap portion a UV-cured adhesive, where said second membrane is adhered to said roof substrate through said adhesive disposed on said roof-substrate contacting portion, and where said second membrane is adhered to said first membrane through said adhesive disposed on said lap portion of said second membrane where the UV-cured adhesive disposed on said second membrane has a substantially consistent degree of cure. i. a roof substrate; ii. a first membrane including first and second opposed planar surfaces, where the first planar surface includes a roof-substrate contacting portion and a lap portion, said first membrane having disposed on said roof-substrate contacting portion and said lap portion a UV-cured adhesive, where said first membrane is adhered to said roof substrate through said adhesive disposed on said roof-substrate contacting portion where the UV-cured adhesive disposed on said first membrane has a substantially consistent degree of cure; and iii. a second membrane including opposed first and second planar surfaces, where the first planar surface includes a roof-substrate contacting portion and a lap portion, said second membrane having disposed on said roof-substrate contacting portion and said lap portion a UV-cured adhesive, where said second membrane is adhered to said roof substrate through said adhesive disposed on said roof-substrate contacting portion, and where said second membrane is adhered to said first membrane through said adhesive disposed on said lap portion of said second membrane where the UV-cured adhesive disposed on said second membrane has a substantially consistent degree of cure.
A method for moving an aqueous droplet , comprising: providing an electrokinetic device, including: a first substrate having a matrix of electrodes , wherein each of the matrix electrodes is coupled to a thin film transistor, and wherein the matrix electrodes are overcoated with a functional coating comprising: a dielectric layer comprising multiple layers of materials selected from silicon nitride, hafnium oxide or aluminum oxide in contact with the matrix electrodes, a conformal layer comprising parylene in contact with the dielectric layer, and a hydrophobic layer in contact with the conformal layer, wherein the parylene acts as a protective coating between the dielectric layer and the hydrophobic layer; a second substrate comprising a top electrode , wherein the second substrate further comprises a second hydrophobic layer disposed on the second electrode; a spacer disposed between the first substrate and the second substrate and defining an electrokinetic workspace between the hydrophobic layers; and a voltage source operatively coupled to the matrix electrodes; providing an aqueous droplet on a first matrix electrode; and providing a differential electrical potential between the first matrix electrode and a second matrix electrode with the voltage source, thereby moving the aqueous droplet between the first matrix electrode and the second matrix electrode. a dielectric layer comprising multiple layers of materials selected from silicon nitride, hafnium oxide or aluminum oxide in contact with the matrix electrodes, a conformal layer comprising parylene in contact with the dielectric layer, and a hydrophobic layer in contact with the conformal layer, wherein the parylene acts as a protective coating between the dielectric layer and the hydrophobic layer; a second substrate comprising a top electrode , wherein the second substrate further comprises a second hydrophobic layer disposed on the second electrode; a spacer disposed between the first substrate and the second substrate and defining an electrokinetic workspace between the hydrophobic layers; and a voltage source operatively coupled to the matrix electrodes; providing an aqueous droplet on a first matrix electrode; and providing a differential electrical potential between the first matrix electrode and a second matrix electrode with the voltage source, thereby moving the aqueous droplet between the first matrix electrode and the second matrix electrode.
An anti-millerian hormone neutralizing antibody which comprises a heavy chain comprising the H-CDR1, H-CDR2 and H-CDR3 of the heavy chain of the antibody obtainable from the hybridoma available under CNCM deposit number I-4965 and a light chain comprising the L-CDR1, L-CDR2 and L-CDR3 of the light chain of the antibody obtainable from the hybridoma available under CNCM deposit number I-4965, wherein the CDRs are identified using the Kabat numbering system.