mhurhangee/patent-ind-claim-en huggingface dataset:
A method of covalently functionalizing carbon nanotubes CNTs grown on a metal film surface according to formula I SURFACE- CNT-A-L-(FG)n, comprising a cycloaddition step; an amide coupling step; and a copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) step, wherein A is the attachment to the CNTs, L is a linker between the attachment on the CNTs and the one or more functional groups (FG)n, further wherein A is a pyrrolidine ring substituted with L on either the nitrogen atom or on C2 or C5 of the pyrrolidine ring system; wherein L is a linker between the attachment A on the CNTs and the FG, selected from the group consisting of: (C 1 -C 30 )alkyl, (C 3 -C 8 )cycloalkyl, aryl, heterocyclyl, and any of these groups (except hydrogen) optionally interrupted by one or more O, N, S, P, Si, or B atoms, and/or one or more carbonyls, and/or substituted by one or more halogen atoms and/or one or more of the following groups, (C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxyC(O), halogen substituted (C 1 -C 12 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, hetrocyclyl, optionally interrupted by one or more, O, N, S, P, Si or B atoms, and wherein L contains one or more carbon atoms; and wherein the FG is selected from the group consisting of: amine, azide, alkyne, carboxylic acid, an activated ester of a carboxylic acid, thiol, acid chloride, acid fluoride, sulfonyl chloride, isocyanate, isothiocyanate, aryl halide, alkyl halide, maleimide, ketone, aldehyde, alcohol, alkene, triflate, nitro, nitrile, boronic acid, boronic ester and a trifluoroborate salt. SURFACE- CNT-A-L-(FG)n, comprising a cycloaddition step; an amide coupling step; and a copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) step, wherein A is the attachment to the CNTs, L is a linker between the attachment on the CNTs and the one or more functional groups (FG)n, further wherein A is a pyrrolidine ring substituted with L on either the nitrogen atom or on C2 or C5 of the pyrrolidine ring system; wherein L is a linker between the attachment A on the CNTs and the FG, selected from the group consisting of: (C 1 -C 30 )alkyl, (C 3 -C 8 )cycloalkyl, aryl, heterocyclyl, and any of these groups (except hydrogen) optionally interrupted by one or more O, N, S, P, Si, or B atoms, and/or one or more carbonyls, and/or substituted by one or more halogen atoms and/or one or more of the following groups, (C 1 -C 12 )alkyl, (C 1 -C 12 )alkoxyC(O), halogen substituted (C 1 -C 12 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, hetrocyclyl, optionally interrupted by one or more, O, N, S, P, Si or B atoms, and wherein L contains one or more carbon atoms; and wherein the FG is selected from the group consisting of: amine, azide, alkyne, carboxylic acid, an activated ester of a carboxylic acid, thiol, acid chloride, acid fluoride, sulfonyl chloride, isocyanate, isothiocyanate, aryl halide, alkyl halide, maleimide, ketone, aldehyde, alcohol, alkene, triflate, nitro, nitrile, boronic acid, boronic ester and a trifluoroborate salt.
An aerosol-forming article comprising: an aerosol-forming substrate ; a terminal hollow bore filter element at a downstream/mouth end of the article ; and an upstream hollow bore filter element upstream of the terminal filter element ; wherein the terminal hollow bore filter element has an axial bore having a smaller diameter than an axial bore in the upstream hollow bore filter element ; characterised in that the axial length of the terminal hollow bore filter element is greater than the axial length of the upstream hollow bore filter element . an aerosol-forming substrate ; a terminal hollow bore filter element at a downstream/mouth end of the article ; and an upstream hollow bore filter element upstream of the terminal filter element ; wherein the terminal hollow bore filter element has an axial bore having a smaller diameter than an axial bore in the upstream hollow bore filter element ; characterised in that the axial length of the terminal hollow bore filter element is greater than the axial length of the upstream hollow bore filter element .
A method of determining the activity of a CD80 extracellular domain (ECD) fusion molecule in a subject comprising determining the frequency of central memory T cells and/or detecting the proliferation of central memory T cells in a sample obtained from the subject after administration of the CD80 ECD fusion molecule to the subject, wherein the CD80 ECD fusion molecule comprises a human CD80 ECD polypeptide and a human IgG1 Fc domain.
A gas turbine engine comprising: a low speed input shaft connected to a low speed tower shaft , in turn connected to a lower speed spool and a high speed input shaft connected to a high speed tower shaft , in turn connected to a higher speed spool , said low speed input shaft being connected to drive a first plurality of accessories, and said high speed input shaft connected to drive a second plurality of accessories; and said high speed tower shaft and said low speed tower shaft being coaxial and rotating about a common axis (I), and providing an angle drive into said low speed input shaft and said high speed input shaft , respectively. a low speed input shaft connected to a low speed tower shaft , in turn connected to a lower speed spool and a high speed input shaft connected to a high speed tower shaft , in turn connected to a higher speed spool , said low speed input shaft being connected to drive a first plurality of accessories, and said high speed input shaft connected to drive a second plurality of accessories; and said high speed tower shaft and said low speed tower shaft being coaxial and rotating about a common axis (I), and providing an angle drive into said low speed input shaft and said high speed input shaft , respectively.
A cysteine-optimized multimerizing stradomer unit comprising from amino to carboxy terminus, an IgG1 Fc domain comprising an IgG1 hinge, IgG1 CH2 and IgG1 CH3 domain and an IgG2 hinge multimerization domain, wherein the stradomer unit comprises at least two stradomer unit monomers and wherein the at least two stradomer unit monomers each comprises the amino acid sequence of SEQ ID NO: 10 with at least one point mutation replacing with another amino acid a cysteine residue in the IgG Fc domain monomer or the IgG2 multimerization domain monomer of SEQ ID NO: 10 at any of positions 5, 11, 14, 152, 210, 237, 240 and 243 of SEQ ID NO: 10.
A chimeric antigen receptor (CAR) comprising an antigen recognition domain, a transmembrane (TM) domain, and a T cell activation domain, wherein the CAR has antigen specificity for B-cell maturation antigen (BCMA), wherein the antigen recognition domain comprises the amino acid sequences of: (a) SEQ ID NOs: 1-3; (b) SEQ ID NOs: 4-6; (c) SEQ ID NOs: 7-9; or (d) SEQ ID NOs: 10-12. (a) SEQ ID NOs: 1-3; (b) SEQ ID NOs: 4-6; (c) SEQ ID NOs: 7-9; or (d) SEQ ID NOs: 10-12.
A fuel system for a gas turbine engine comprising: a primary fuel pump providing fuel flow during engine operation; a primary electric motor coupled to the primary fuel pump for driving the primary fuel pump during engine operation; and a secondary system providing fuel flow in the absence of fuel flow from the primary fuel pump ; and characterized in that the secondary system comprises a secondary pump powered by a hydraulically powered turbine. a primary fuel pump providing fuel flow during engine operation; a primary electric motor coupled to the primary fuel pump for driving the primary fuel pump during engine operation; and a secondary system providing fuel flow in the absence of fuel flow from the primary fuel pump ; and characterized in that the secondary system comprises a secondary pump powered by a hydraulically powered turbine.
A detector unit for use in an aspirating detection system within a building, comprising: an aspirator for drawing air from an interior of the building along at least one sampling pipe and into the detector unit; a sensor chamber for analysing a sample of the air drawn into the detector unit; a Venturi conduit through which the air is moved by the aspirator, the Venturi conduit comprising a first portion of the Venturi conduit and a second portion of the Venturi conduit, a cross-sectional area of the first portion being smaller than a cross-sectional area of the second portion; a pressure sensor configured to detect a differential pressure between the air in the first portion and the air in the second portion of the Venturi conduit; and a controller configured to determine a leak and/or blockage within the aspirating detection system based on the detected differential pressure. an aspirator for drawing air from an interior of the building along at least one sampling pipe and into the detector unit; a sensor chamber for analysing a sample of the air drawn into the detector unit; a Venturi conduit through which the air is moved by the aspirator, the Venturi conduit comprising a first portion of the Venturi conduit and a second portion of the Venturi conduit, a cross-sectional area of the first portion being smaller than a cross-sectional area of the second portion; a pressure sensor configured to detect a differential pressure between the air in the first portion and the air in the second portion of the Venturi conduit; and a controller configured to determine a leak and/or blockage within the aspirating detection system based on the detected differential pressure.
Cell therapy product comprising mammalian therapeutic cells for use in the treatment of a solid tumor disease, a disease associated with inflammation or a disorder of the central nervous system (CNS) or neurological or neurodegenerative disorder, wherein the use of said cell therapy product comprises administration of a vascular endothelial damaging agent prior to or in combination with administration of said cell therapy product.
A method performed at a first device coupled with a second device via a first transmission line (335-b) and a second transmission line (335-a, 335-c), comprising: identifying (615; 905), by the first device , a first multi-level signal at the first transmission line (335-b), the first multi-level signal modulated according to a modulation scheme that includes three or more voltage levels : and identifying (620; 910), by the first device , a second multi-level signal at the second transmission line (335-a, 335-c), the second multi-level signal modulated according to the modulation scheme; determining (715; 1015), by the first device , a difference in voltage level (430; 515) of the second multi-level signal for a second symbol and a first symbol that is immediately before the second symbol; estimating (625; 915), by the first device , a crosstalk contribution ( C exp ) of the second multi-level signal to the first multi-level signal based at least in part on the difference in voltage level (430; 515); generating (630; 920), by the first device based at least in part on determining that the difference in voltage level (430; 515) satisfies a threshold, a modified first multi-level signal that comprises the first multi-level signal and a cancelation signal ( C sig ) that is based at least in part on the estimated crosstalk contribution; and transmitting (635; 925), by the first device , the modified first multi-level signal over the first transmission line (335-b). identifying (615; 905), by the first device , a first multi-level signal at the first transmission line (335-b), the first multi-level signal modulated according to a modulation scheme that includes three or more voltage levels : and identifying (620; 910), by the first device , a second multi-level signal at the second transmission line (335-a, 335-c), the second multi-level signal modulated according to the modulation scheme; determining (715; 1015), by the first device , a difference in voltage level (430; 515) of the second multi-level signal for a second symbol and a first symbol that is immediately before the second symbol; estimating (625; 915), by the first device , a crosstalk contribution ( C exp ) of the second multi-level signal to the first multi-level signal based at least in part on the difference in voltage level (430; 515); generating (630; 920), by the first device based at least in part on determining that the difference in voltage level (430; 515) satisfies a threshold, a modified first multi-level signal that comprises the first multi-level signal and a cancelation signal ( C sig ) that is based at least in part on the estimated crosstalk contribution; and transmitting (635; 925), by the first device , the modified first multi-level signal over the first transmission line (335-b).
A flexible pipe for subsea transportation of production fluids, comprising: a fluid retaining layer ; an outer sheath ; and at least one tensile armour layer comprising a plurality of helically wound monofilament armour wires of a first material, each having a non-circular cross section with an aspect ratio of greater than 1:2 disposed between the fluid retaining layer and the outer sheath ; and characterised in that : the tensile armour layer further comprises at least one helically wound elongate anode element substantially having a cross-section aspect ratio of 1:1 and comprising a further material, interposed between armour wires , the anode element cross section having an area that is 50% or less of a corresponding area of said non-circular cross section. a fluid retaining layer ; an outer sheath ; and at least one tensile armour layer comprising a plurality of helically wound monofilament armour wires of a first material, each having a non-circular cross section with an aspect ratio of greater than 1:2 disposed between the fluid retaining layer and the outer sheath ; and characterised in that : the tensile armour layer further comprises at least one helically wound elongate anode element substantially having a cross-section aspect ratio of 1:1 and comprising a further material, interposed between armour wires , the anode element cross section having an area that is 50% or less of a corresponding area of said non-circular cross section.
An air gap eductor for mixing a diluent with a chemical, comprising: an eductor body , comprising: a nozzle section having an inlet portion and an air gap portion , the inlet portion configured to couple to a diluent source and the air gap portion open to the atmosphere; and a venturi section coupled to the nozzle section , the venturi section including a venturi configured to couple to a chemical source for drawing chemical into the venturi with the flow of diluent through the venturi ; and a nozzle assembly positioned in the nozzle section of the eductor body , characterized in that the venturi section is coupled to the nozzle section by a swivel joint. an eductor body , comprising: a nozzle section having an inlet portion and an air gap portion , the inlet portion configured to couple to a diluent source and the air gap portion open to the atmosphere; and a venturi section coupled to the nozzle section , the venturi section including a venturi configured to couple to a chemical source for drawing chemical into the venturi with the flow of diluent through the venturi ; and a nozzle section having an inlet portion and an air gap portion , the inlet portion configured to couple to a diluent source and the air gap portion open to the atmosphere; and a venturi section coupled to the nozzle section , the venturi section including a venturi configured to couple to a chemical source for drawing chemical into the venturi with the flow of diluent through the venturi ; and a nozzle assembly positioned in the nozzle section of the eductor body , characterized in that the venturi section is coupled to the nozzle section by a swivel joint.
An interlock comprising - a locking element that can move in parallel with a locking direction, - and a drive comprising a transfer element for moving the locking element , which transfer element is coupled to a motor via a transmission for shifting in the longitudinal direction, wherein the transfer element is coupled to the locking element via a coupling such that the transfer element can move with the locking element in a first direction of movement (L) and a second, opposite direction of movement, - wherein the coupling is spring-buffered under preload in both directions of movement such that, when the locking element is blocked, a movement of the transfer element in both directions of movement by a spring travel (A) against a spring force is possible when the preload is overcome. - a locking element that can move in parallel with a locking direction, - and a drive comprising a transfer element for moving the locking element , which transfer element is coupled to a motor via a transmission for shifting in the longitudinal direction, wherein the transfer element is coupled to the locking element via a coupling such that the transfer element can move with the locking element in a first direction of movement (L) and a second, opposite direction of movement, - wherein the coupling is spring-buffered under preload in both directions of movement such that, when the locking element is blocked, a movement of the transfer element in both directions of movement by a spring travel (A) against a spring force is possible when the preload is overcome.
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A is selected from: or wherein A is substituted with 0, 1, 2, or 3 R 4 , each independently selected from C 1 -C 10 alkyl, C 1 - 10 haloalkyl, C 3 - 12 heterocycloalkylC 0 - 6 alkyl, C 3 - 12 cycloalkyl(C 0 - 6 alkyl), amino, C 3 - 12 cycloalkyl(C 0 - 6 alkyl)aminocarbonyl, C 1 - 6 alkylamino(C 0 - 6 alkyl), C 3 - 12 heterocycloalkylcarbonyl(C 0 - 6 alkyl), C 1 - 10 alkylcarbonyl(C 0 - 6 alkyl), C 3 - 12 cycloalkylcarbonyl(C 0 - 6 alkyl), C 1 - 10 alkylcarboxy, or C 1 - 10 alkyloxy(C 0 - 6 alkyl), wherein each R 4 is independently substituted by 0, 1, 2, or 3 R 5 independently selected from halogen, hydroxy, C 1 - 6 alkyl, C 1 - 4 alkoxy, or C 1 - 6 haloalkyl; each R 1 and R 2 is independently selected from: hydrogen, or cyano provided that only one of R 1 or R 2 is cyano and the other is hydrogen; and R 3 is hydrogen, C 1 - 6 haloalkyl, or C 1 - 6 alkyl. A is selected from: or wherein A is substituted with 0, 1, 2, or 3 R 4 , each independently selected from C 1 -C 10 alkyl, C 1 - 10 haloalkyl, C 3 - 12 heterocycloalkylC 0 - 6 alkyl, C 3 - 12 cycloalkyl(C 0 - 6 alkyl), amino, C 3 - 12 cycloalkyl(C 0 - 6 alkyl)aminocarbonyl, C 1 - 6 alkylamino(C 0 - 6 alkyl), C 3 - 12 heterocycloalkylcarbonyl(C 0 - 6 alkyl), C 1 - 10 alkylcarbonyl(C 0 - 6 alkyl), C 3 - 12 cycloalkylcarbonyl(C 0 - 6 alkyl), C 1 - 10 alkylcarboxy, or C 1 - 10 alkyloxy(C 0 - 6 alkyl), wherein each R 4 is independently substituted by 0, 1, 2, or 3 R 5 independently selected from halogen, hydroxy, C 1 - 6 alkyl, C 1 - 4 alkoxy, or C 1 - 6 haloalkyl; each R 1 and R 2 is independently selected from: hydrogen, or cyano provided that only one of R 1 or R 2 is cyano and the other is hydrogen; and R 3 is hydrogen, C 1 - 6 haloalkyl, or C 1 - 6 alkyl.
A storage unit for storing a material, the storage unit comprising: at least one wall, the at least one wall defining a chamber; an opening; a storage unit valve arranged at the opening to selectively seal the chamber, the storage unit valve being able to be selectively opened and closed to allow fluid to flow through the storage unit valve ; and a storage unit keying mechanism configured to allow the storage unit to only connect to a complementary docking station keying mechanism disposed on a docking station for receiving the storage unit; characterized in that the storage unit valve is configured to only be able to be selectively opened and closed when the storage unit keying mechanism is engaged with said complementary docking station keying mechanism, preferably wherein the storage unit is an ink cartridge and the material is a fluid such as ink. at least one wall, the at least one wall defining a chamber; an opening; a storage unit valve arranged at the opening to selectively seal the chamber, the storage unit valve being able to be selectively opened and closed to allow fluid to flow through the storage unit valve ; and a storage unit keying mechanism configured to allow the storage unit to only connect to a complementary docking station keying mechanism disposed on a docking station for receiving the storage unit; characterized in that the storage unit valve is configured to only be able to be selectively opened and closed when the storage unit keying mechanism is engaged with said complementary docking station keying mechanism, preferably wherein the storage unit is an ink cartridge and the material is a fluid such as ink.
A lipase comprising an amino acid sequence which has at least 70% sequence identity with the amino acid sequence given in SEQ ID NO:1 over the entire length thereof and which has at least one amino acid substitution at at least one of the positions corresponding to positions 83, 86, 87, 89, 90, 92, 93, 95, 113, 174, 202, 203, 205, 206, 207, 208, 209, 211, 227, 252, 253, 256, 258, 259, 260, 264, or 267, in each case based on the numbering according to SEQ ID NO:1, wherein the at least one amino acid substitution is selected from the group consisting of 208N and 253N, in each case based on the numbering according to SEQ ID NO:1.
A liquid laundry detergent comprising at least one surfactant in an aqueous medium, characterised in that it further comprises at least one water-soluble metasilicate, at least one water-soluble bicarbonate, at least one water-soluble glutamate and at least one polymeric rheology modifier.
A method, comprising: performing, by one or more computing devices including a virtual machine compute instance implemented on an instance host: determining that a software stack running on the instance host and/or at the virtual machine compute instance meets one or more security criteria associated with execution of the virtual machine compute instance; transmitting, to the instance host, an encrypted representation of one or more credentials to be used at the compute instance to implement one or more operations on behalf of a client; receiving , at the instance host, the encrypted representation of the one or more credentials ; extracting the one or more credentials from the encrypted representation into a non-persistent memory location at the instance host using a private key available at the instance host, wherein said one or more credentials are only extracted following re-verification that the software stack meets the one or more security criteria at the time that extraction is attempted after the encrypted credentials are received at the instance host; implementing the one or more operations at the virtual machine compute instance using the one or more credentials; and discarding the one or more credentials from the instance host, without saving the one or more credentials to a persistent store. determining that a software stack running on the instance host and/or at the virtual machine compute instance meets one or more security criteria associated with execution of the virtual machine compute instance; transmitting, to the instance host, an encrypted representation of one or more credentials to be used at the compute instance to implement one or more operations on behalf of a client; receiving , at the instance host, the encrypted representation of the one or more credentials ; extracting the one or more credentials from the encrypted representation into a non-persistent memory location at the instance host using a private key available at the instance host, wherein said one or more credentials are only extracted following re-verification that the software stack meets the one or more security criteria at the time that extraction is attempted after the encrypted credentials are received at the instance host; implementing the one or more operations at the virtual machine compute instance using the one or more credentials; and discarding the one or more credentials from the instance host, without saving the one or more credentials to a persistent store.