mhurhangee/patent-ind-claim-en huggingface dataset:
A method of predicting de novo resistance to androgen receptor (AR) targeted therapy in a tumor of a prostate cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to generate circulating tumor cell (CTC) data, wherein the analysis comprises determining a measurable feature of a panel of traditional and non-traditional CTC biomarkers for de novo resistance to androgen receptor (AR) targeted therapy, wherein the biomarkers comprise CTC heterogeneity, frequency of cytokeratin positive (CK+), AR N-terminal positive CTCs with prominent nucleoli morphology, and frequency of AR C-terminal truncated CTCs, and wherein the CTC heterogeneity comprises biomarkers selected from the group consisting of traditional CTCs, CTC clusters, CK- CTCs, small CTCs, nucleoli+ CTCs, CK speckled CTCs and (b) evaluating the CTC data to determine the probability of de novo resistance to the AR targeted therapy in the tumor of the prostate cancer patient, wherein greater CTC heterogeneity, increased frequency of CK+, AR N-terminal positive CTCs with prominent nucleoli morphology, or increased frequency of AR C-terminal truncated CTCs, compared to patients responsive to AR therapy, predicts de novo resistance to AR therapy (a) performing a direct analysis comprising immunofluorescent staining and morphological characteristization of nucleated cells in a blood sample obtained from the patient to generate circulating tumor cell (CTC) data, wherein the analysis comprises determining a measurable feature of a panel of traditional and non-traditional CTC biomarkers for de novo resistance to androgen receptor (AR) targeted therapy, wherein the biomarkers comprise CTC heterogeneity, frequency of cytokeratin positive (CK+), AR N-terminal positive CTCs with prominent nucleoli morphology, and frequency of AR C-terminal truncated CTCs, and wherein the CTC heterogeneity comprises biomarkers selected from the group consisting of traditional CTCs, CTC clusters, CK- CTCs, small CTCs, nucleoli+ CTCs, CK speckled CTCs and (b) evaluating the CTC data to determine the probability of de novo resistance to the AR targeted therapy in the tumor of the prostate cancer patient,
A solid oxide fuel cell comprising an electrode-electrolyte assembly and an interconnect in communication with the electrode-electrolyte assembly, wherein the interconnect comprises a carbon matrix composite, wherein the interconnect includes an inner core and an outer surface and has a porosity that increases from the inner core to the outer surface.
A process for the preparation of brivaracetam, a compound of formula I, or a salt thereof, the process comprising: i) reacting a compound of formula VI with L-menthol to obtain a compound of formula IV, wherein X= Cl, Br, I, OMs or OTs; ii) reacting the compound of formula IV with -2-aminobutanamide, a compound of formula III, to obtain a diastereomeric mixture, a compound of formula II; iii) separating the desired diastereomer, a compound of formula IIA and the undesired diastereomer, a compound of formula IIB, from the diastereomeric mixture, the compound of formula II; and iv) cyclizing the compound of formula IIA, to obtain brivaracetam the compound of formula I. i) reacting a compound of formula VI with L-menthol to obtain a compound of formula IV, wherein X= Cl, Br, I, OMs or OTs; ii) reacting the compound of formula IV with -2-aminobutanamide, a compound of formula III, to obtain a diastereomeric mixture, a compound of formula II; iii) separating the desired diastereomer, a compound of formula IIA and the undesired diastereomer, a compound of formula IIB, from the diastereomeric mixture, the compound of formula II; and iv) cyclizing the compound of formula IIA, to obtain brivaracetam the compound of formula I.
A device for the pre-degassing of a fuel tank, comprising an air pump , an insufflation pipe connected to the pump , and a collector pipe connected to a filter , wherein the device is designed to drive, by means of the pump , an air stream through the insufflation pipe towards a fuel tank , and an air stream mixed with inner gases of the tank , through the collector pipe , towards the filter equipment , wherein the device is further designed to expel, through an exhaust route of the filter equipment , a filtered clean air flow, wherein the filter equipment comprises at least one filter designed to carry out an adsorption of flammable volatile particles of the inner gases of the tank , wherein the device is designed to connect the insufflation pipe to a first nozzle for filling the tank and to connect the collector pipe to a second nozzle for emptying the tank ; and characterized in that the device comprises a cooling pipe connected to the pump and to an inlet nozzle of the filter equipment , and wherein the device is designed to drive, by means of the pump and through the cooling pipe , a cooling air stream towards the filter equipment .
A forming tool for shaping a workpiece , especially a flat sheet, the forming tool comprising: - a female part , a holding-down device , and a male part , which are each arranged so as to be movable relative to one another, the female part , the holding-down device and/or the male part being temperature-controllable at least in some sections, characterised in that at least one indentation, especially a blind hole, is provided for the temperature control and can be flushed with a medium, and in that a baffle is introduced in an indentation in order to guide the medium. - a female part , a holding-down device , and a male part , which are each arranged so as to be movable relative to one another,
A method of wireless communication in a wireless communication system according to an 802.11 protocol comprising wireless devices including an access point , and a first station and at least one other station (106B-106D) acting as clients to the access point , the method comprising: generating , at the first wireless station , a first packet comprising a first preamble decodable by a plurality of devices and a second preamble decodable by only a subset of the plurality of devices, the first preamble comprising a first signal field, wherein the first signal field is an L-SIG field using binary phase shift keying, BPSK modulation, and the second preamble comprising a first training field; transmitting , by the first wireless station , the first packet concurrently with transmission of at least one second packet by at least one other station (106B-106D), a length of the first packet being shorter than a length of at least one second packet, and the at least one other station (106B-106D) being assigned to a common zone of physical layer data unit, PPDU bandwidth with the first wireless station ; and setting, by the first wireless station , the first signal field to indicate a length of the first packet equal to a maximum of packet lengths in the common zone. generating , at the first wireless station , a first packet comprising a first preamble decodable by a plurality of devices and a second preamble decodable by only a subset of the plurality of devices, the first preamble comprising a first signal field, wherein the first signal field is an L-SIG field using binary phase shift keying, BPSK modulation, and the second preamble comprising a first training field; transmitting , by the first wireless station , the first packet concurrently with transmission of at least one second packet by at least one other station (106B-106D), a length of the first packet being shorter than a length of at least one second packet, and the at least one other station (106B-106D) being assigned to a common zone of physical layer data unit, PPDU bandwidth with the first wireless station ; and setting, by the first wireless station , the first signal field to indicate a length of the first packet equal to a maximum of packet lengths in the common zone.
A method of purifying a target analyte with an apatite solid surface, the method comprising: (a) contacting the apatite solid surface with the target analyte, thereby separating the target analyte from one or more contaminants; (b) collecting the target analyte; and (c) regenerating the apatite solid surface, the regenerating comprising: (i) contacting the apatite solid surface with a buffered calcium solution comprising a calcium ion at a concentration of at least 10 mM and a non-zwitterionic buffer having a primary, secondary or tertiary amine, wherein the ratio of the buffer concentration to the calcium ion concentration is at least 0.2, and wherein the pH of the buffered calcium solution is between 7 and 9; followed by (ii) contacting the apatite solid surface with a phosphate buffered solution at a pH of at least 6.5; followed by (iii) contacting the apatite solid surface with a solution comprising an alkaline hydroxide. (a) contacting the apatite solid surface with the target analyte, thereby separating the target analyte from one or more contaminants; (b) collecting the target analyte; and (c) regenerating the apatite solid surface, the regenerating comprising: (i) contacting the apatite solid surface with a buffered calcium solution comprising a calcium ion at a concentration of at least 10 mM and a non-zwitterionic buffer having a primary, secondary or tertiary amine, wherein the ratio of the buffer concentration to the calcium ion concentration is at least 0.2, and wherein the pH of the buffered calcium solution is between 7 and 9; followed by (ii) contacting the apatite solid surface with a phosphate buffered solution at a pH of at least 6.5; followed by (iii) contacting the apatite solid surface with a solution comprising an alkaline hydroxide. (i) contacting the apatite solid surface with a buffered calcium solution comprising a calcium ion at a concentration of at least 10 mM and a non-zwitterionic buffer having a primary, secondary or tertiary amine, wherein the ratio of the buffer concentration to the calcium ion concentration is at least 0.2, and wherein the pH of the buffered calcium solution is between 7 and 9; followed by (ii) contacting the apatite solid surface with a phosphate buffered solution at a pH of at least 6.5; followed by (iii) contacting the apatite solid surface with a solution comprising an alkaline hydroxide.
An ammonia-process desulfurization absorption tower, comprising a tower body, a tower chamber being formed inside the tower body, and the tower body being provided with a lower flue gas inlet and an upper flue gas outlet for guiding a flue gas, an upper circulating liquid inlet and a lower circulating liquid outlet for guiding a desulfurization absorption liquid, and a process water inlet for supplementing a process water, characterized in that , the tower body comprises an internal anti-corrosion layer that is designed for contacting the flue gas and the desulfurization absorption liquid, defines the tower chamber, and is made of a stainless steel plate whose thickness is 1.0 mm to 6.0 mm, and an external supporting layer that is designed for supporting the anti-corrosion layer and is made of carbon steel, especially carbon steel whose material type is Q235 or Q345, wherein the supporting layer and the anti-corrosion layer are designed to jointly bear a load, wherein the supporting layer is designed to bear a large part of the load, and the anti-corrosion layer is designed to bear a small part of the load, wherein the anti-corrosion layer comprises a bottom plate , a cylinder , and a top plate , wherein the cylinder comprises two or more sections along a height direction and stainless steel materials of the sections are selected in dependence on an expected chloride ion concentration of the desulfurization absorption liquid during operation of the desulfurization absorption tower.
A method of obfuscating a computer program by representing the control flow of the computer program as data that is not source code, the method comprising: receiving source code of a computer program , the source code including a plurality of computing functions of the program and control flow of the program which defines the order in which the computing functions are executed; parsing the source code ; extracting at least a part of the control flow of the source code ; representing at least a portion of the control flow as a control flow model using a mathematical modeling language , the modeling language including constructs for event elements representing events that occur during execution of the computer program, condition elements which represent conditions that occur during the execution of the computer program and execution elements which are linked to portions of the source code for executing functions, wherein arcs are used to link event elements with condition elements and execution elements and wherein tokens are associated with condition elements and execution elements to represent the state of execution of the computer program; storing the control flow model as control flow data that represents the control flow of the program, wherein the control flow data is not executable code ; and removing the at least a portion of the control flow from the source code, to thereby obfuscate the control flow of the source code and render the source code more resistant to tampering . receiving source code of a computer program , the source code including a plurality of computing functions of the program and control flow of the program which defines the order in which the computing functions are executed; parsing the source code ; extracting at least a part of the control flow of the source code ; representing at least a portion of the control flow as a control flow model using a mathematical modeling language , the modeling language including constructs for event elements representing events that occur during execution of the computer program, condition elements which represent conditions that occur during the execution of the computer program and execution elements which are linked to portions of the source code for executing functions, wherein arcs are used to link event elements with condition elements and execution elements and wherein tokens are associated with condition elements and execution elements to represent the state of execution of the computer program; storing the control flow model as control flow data that represents the control flow of the program, wherein the control flow data is not executable code ; and removing the at least a portion of the control flow from the source code, to thereby obfuscate the control flow of the source code and render the source code more resistant to tampering .
Teat for use with a container for containing a fluid, comprising: - a deformable mouthpiece for an infant to suck on during a fluid intake action, the mouthpiece having at least one aperture therein for allowing a fluid to flow out of the teat ; and - an inner core disposed within the mouthpiece , wherein an exterior surface of the inner core is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face of the exterior surface of the inner core extending along a length of the inner core so that a fluid duct between the mouthpiece and the inner core is defined which allows the infant to perform a peristaltic fluid intake action during which the mouthpiece is deformed and a fluid is forced along the fluid duct in a direction towards the at least one aperture of the mouthpiece , characterised in that at least one of the interior surface of the mouthpiece and the exterior surface of the inner core has at least one protrusion that is configured and arranged to form a fluid barrier between the mouthpiece and the inner core at a position for delimiting the fluid duct at the sides thereof. - a deformable mouthpiece for an infant to suck on during a fluid intake action, the mouthpiece having at least one aperture therein for allowing a fluid to flow out of the teat ; and - an inner core disposed within the mouthpiece , wherein an exterior surface of the inner core is spaced from an interior surface of the mouthpiece at the position of a fluid pocket guiding face of the exterior surface of the inner core extending along a length of the inner core so that a fluid duct between the mouthpiece and the inner core is defined which allows the infant to perform a peristaltic fluid intake action during which the mouthpiece is deformed and a fluid is forced along the fluid duct in a direction towards the at least one aperture of the mouthpiece , characterised in that at least one of the interior surface of the mouthpiece and the exterior surface of the inner core has at least one protrusion that is configured and arranged to form a fluid barrier between the mouthpiece and the inner core at a position for delimiting the fluid duct at the sides thereof.
Method for the closed loop longitudinal control of a vehicle as a function of a target trajectory (T soll ) which specifies a series of target positions (P k-n to P k+m ) to be assumed by the vehicle over the time (t), wherein - based on an actual state (Z) of the vehicle , a closed loop controller actuating acceleration (a ctrl ) for closed loop trajectory control is determined, by means of which the vehicle is to be accelerated in accordance with specifications of the target trajectory (T soll ), - during following of the target trajectory (T soll ) by the vehicle , a curvature (K) of the target trajectory (T soll ) is determined from a local course of the target trajectory (T soll ) at a current position of the vehicle , - an acceleration offset (a offset ) which decreases with increasing curvature (K) is determined based on the curvature (K), - during the following of the target trajectory (T soll ), a longitudinal acceleration resulting from the target trajectory (T soll ) is determined at the current position of the vehicle as the current trajectory acceleration (a refPtOrth ), - the closed loop controller actuating acceleration (a ctrl ) is limited to a value which corresponds at most to a sum of the current trajectory acceleration (a refPtOrth ) and the acceleration offset (a offset ), and - the vehicle is accelerated in accordance with the limited closed loop controller actuating acceleration (a ctrl_lim ). - based on an actual state (Z) of the vehicle , a closed loop controller actuating acceleration (a ctrl ) for closed loop trajectory control is determined, by means of which the vehicle is to be accelerated in accordance with specifications of the target trajectory (T soll ), - during following of the target trajectory (T soll ) by the vehicle , a curvature (K) of the target trajectory (T soll ) is determined from a local course of the target trajectory (T soll ) at a current position of the vehicle , - an acceleration offset (a offset ) which decreases with increasing curvature (K) is determined based on the curvature (K), - during the following of the target trajectory (T soll ), a longitudinal acceleration resulting from the target trajectory (T soll ) is determined at the current position of the vehicle as the current trajectory acceleration (a refPtOrth ), - the closed loop controller actuating acceleration (a ctrl ) is limited to a value which corresponds at most to a sum of the current trajectory acceleration (a refPtOrth ) and the acceleration offset (a offset ), and - the vehicle is accelerated in accordance with the limited closed loop controller actuating acceleration (a ctrl_lim ).
A pulse cycle detection device comprising: a sensor for sensing a pulse wave signal of a subject; and a processor for processing a digital pulse wave signal which is analog-to-digital converted from the pulse wave signal sensed by the sensor, to detect the pulse cycle of the subject, wherein the processor is configured to perform operations of: calculating a differential value of the digital pulse wave signal over time; determining that the pulse wave signal reaches a maximum point and recording a time value corresponding to the maximum point, whenever a transition from positive to negative occurs to the differential value; recognizing a last recorded maximum point as a peak point of the pulse wave signal, once the differential value is less than a dynamic threshold; and calculating a difference between time values corresponding to two successive peak points for deriving the pulse cycle. a sensor for sensing a pulse wave signal of a subject; and a processor for processing a digital pulse wave signal which is analog-to-digital converted from the pulse wave signal sensed by the sensor, to detect the pulse cycle of the subject, wherein the processor is configured to perform operations of: calculating a differential value of the digital pulse wave signal over time; determining that the pulse wave signal reaches a maximum point and recording a time value corresponding to the maximum point, whenever a transition from positive to negative occurs to the differential value; recognizing a last recorded maximum point as a peak point of the pulse wave signal, once the differential value is less than a dynamic threshold; and calculating a difference between time values corresponding to two successive peak points for deriving the pulse cycle. calculating a differential value of the digital pulse wave signal over time; determining that the pulse wave signal reaches a maximum point and recording a time value corresponding to the maximum point, whenever a transition from positive to negative occurs to the differential value; recognizing a last recorded maximum point as a peak point of the pulse wave signal, once the differential value is less than a dynamic threshold; and calculating a difference between time values corresponding to two successive peak points for deriving the pulse cycle.
A method for full duplex communication including simultaneous transmission of upstream and downstream signals in a same frequency band by a device at a position in a network following a full duplex, FDX, Data Over Cable Service Interface Specification, DOCSIS, in a downstream direction, the method comprising: receiving , by the device, a downstream signal as a downstream analog signal from the FDX DOCSIS node and an upstream signal as an upstream analog signal in the same frequency band; separating , by one or more directional couplers of the device, the downstream analog signal and the upstream analog signal into a first path and a second path of the device, respectively; amplifying , by the device, the separated downstream analog signal using the first path and the separated upstream analog signal using the second path; isolating, by the device, the amplified downstream analog signal and the amplified upstream analog signal from one another, wherein isolating the amplified downstream analog signal and the amplified upstream analog signal comprises canceling crosstalk from the amplified downstream analog signal and/or the amplified upstream analog signal; sending , by the device, the amplified downstream analog signal downstream towards a subscriber device ; and sending , by device, the amplified upstream analog signal towards the FDX DOCSIS node. receiving , by the device, a downstream signal as a downstream analog signal from the FDX DOCSIS node and an upstream signal as an upstream analog signal in the same frequency band; separating , by one or more directional couplers of the device, the downstream analog signal and the upstream analog signal into a first path and a second path of the device, respectively; amplifying , by the device, the separated downstream analog signal using the first path and the separated upstream analog signal using the second path; isolating, by the device, the amplified downstream analog signal and the amplified upstream analog signal from one another, wherein isolating the amplified downstream analog signal and the amplified upstream analog signal comprises canceling crosstalk from the amplified downstream analog signal and/or the amplified upstream analog signal; sending , by the device, the amplified downstream analog signal downstream towards a subscriber device ; and sending , by device, the amplified upstream analog signal towards the FDX DOCSIS node.