mhurhangee/patent-ind-claim-en huggingface dataset:
A pharmaceutical composition comprising a polypeptide comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO:35, and a pharmaceutically acceptable carrier; wherein (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at a pH equivalent to the pH in the human stomach; (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp; and the polypeptide comprises an amino acid change from SEQ ID NO: 67 at one or more residues selected from the group consisting of amino acid residues 73, 102, 103, 104, 130, 165, 168, 169, 172, and 179; for use in a method of: - treating celiac sprue in an individual in need thereof, - degrading gliadin in a meal ingested by an individual in need of such treatment, - treating an inflammatory reaction to gluten in an individual in need thereof, or - treating gluten intolerance in an individual in need thereof. (a) the polypeptide degrades a PQPQLP (SEQ ID NO:34) peptide at a pH equivalent to the pH in the human stomach; (b) residue 278 is Ser, residue 78 is Glu, and residue 82 is Asp; and - treating celiac sprue in an individual in need thereof, - degrading gliadin in a meal ingested by an individual in need of such treatment, - treating an inflammatory reaction to gluten in an individual in need thereof, or - treating gluten intolerance in an individual in need thereof.
Method for producing closing systems for hygiene articles, in particular nappy closing systems, wherein a fixing element is applied to the rear side of a supporting element with protruding fastening elements , which are arranged in rows at a pre-definable distance from one another, and joined to said supporting element by means of an ultrasonic bonding process along bonding points, at least some of the bonding points being applied along bonding lines between adjacent rows of fastening elements and running at least partially parallel to these rows, wherein at least one anvil part of an ultrasonic bonding device is engaged between the rows of fastening elements arranged adjacent to spaces and running parallel to these rows for the purpose of obtaining the respective bonding line , and wherein the sonotrode or sonotrode part interacting with the respective anvil part comes into contact with the side of the fixing element which faces away from the fastening elements , characterised in that the respective anvil parts are used as constituent parts of a block die , in that a plurality of anvil parts held a pre-definable distance from each other to adapt to the row spacing between the fastening elements of the supporting element form parts of the block die running parallel to one another, and in that , to obtain a guide for the supporting element , which is moved together with the fixing element along the block die for a bonding process, anvil parts acting as guide strips are used on the block die , said anvil parts engaging in the spaces between the adjacent rows of fastening elements .
An electronic device comprising: a first finite impulse response, i.e., "FIR", filter that receives an input signal and a first reference signal , wherein the first FIR filter filters the first reference signal to generate a first sinusoidal signal and mixes the first sinusoidal signal and the input signal to generate a first mixed signal; a second FIR filter that receives the input signal and a second reference signal , wherein the second FIR filter filters the second reference signal to generate a second sinusoidal signal and mixes the second sinusoidal signal and the input signal to generate a second mixed signal; and a controller coupled with the first FIR filter and the second FIR filter, the controller configured to determine a characteristic of the input signal based on the first mixed signal and the second mixed signal. a first finite impulse response, i.e., "FIR", filter that receives an input signal and a first reference signal , wherein the first FIR filter filters the first reference signal to generate a first sinusoidal signal and mixes the first sinusoidal signal and the input signal to generate a first mixed signal; a second FIR filter that receives the input signal and a second reference signal , wherein the second FIR filter filters the second reference signal to generate a second sinusoidal signal and mixes the second sinusoidal signal and the input signal to generate a second mixed signal; and a controller coupled with the first FIR filter and the second FIR filter, the controller configured to determine a characteristic of the input signal based on the first mixed signal and the second mixed signal.
A compound which is an inhibitor of the GluK2/GluK5 receptor expression for use in the treatment or the prevention of epilepsy, wherein the inhibitor is an antisense oligonucleotide, a small double stranded RNA (dsRNA) or a small inhibitory RNA (siRNA) to the GluK2/GluK5 receptor.
A humidification chamber for a respiratory therapy system, the humidification chamber being configured to hold a fluid in a fluid reservoir , and comprising: a base , a top wall and an outer side wall extending between the base and the top wall ; an inner side wall at least partially defining the fluid reservoir , and spaced at a distance from the outer side wall to form a wall cavity , between the inner side wall and the outer side wall , that surrounds the inner side wall of the humidification chamber ; a guide extending from the inner side wall to the outer side wall across the wall cavity , the guide defining an insulating channel through the wall cavity ; a chamber inlet for receiving breathing gas, the chamber inlet comprising an opening into the wall cavity ; a fluid reservoir inlet , the fluid reservoir inlet providing a path for gas to flow from the wall cavity to the fluid reservoir ; a delivery outlet for delivering breathing gas from the fluid reservoir externally of the humidification chamber ; wherein the insulating channel , fluid reservoir inlet and fluid reservoir provide a chamber gas flow path that extends between the chamber inlet and the delivery outlet . a base , a top wall and an outer side wall extending between the base and the top wall ; an inner side wall at least partially defining the fluid reservoir , and spaced at a distance from the outer side wall to form a wall cavity , between the inner side wall and the outer side wall , that surrounds the inner side wall of the humidification chamber ; a guide extending from the inner side wall to the outer side wall across the wall cavity , the guide defining an insulating channel through the wall cavity ; a chamber inlet for receiving breathing gas, the chamber inlet comprising an opening into the wall cavity ; a fluid reservoir inlet , the fluid reservoir inlet providing a path for gas to flow from the wall cavity to the fluid reservoir ; a delivery outlet for delivering breathing gas from the fluid reservoir externally of the humidification chamber ; wherein the insulating channel , fluid reservoir inlet and fluid reservoir provide a chamber gas flow path that extends between the chamber inlet and the delivery outlet .
An echelle grating, comprising: a first interface ; a second interface ; a first plurality of output waveguides , at the first interface; one or more input waveguides , at the second interface; and a free propagation region connecting the first plurality of output waveguides and the one or more input waveguides , a first waveguide, of the first plurality of output waveguides , having a first width, a second waveguide, of the of the first plurality of output waveguides , having a second width, the echelle grating being configured: when light is received at a first wavelength in one of the one or more input waveguides, to direct the light at the first wavelength to the first waveguide; and when light is received at a second wavelength in one of the one or more input waveguides, to direct the light at the second wavelength to the second waveguide, characterised by the first width being at least 5% greater than the second width, and a ratio of the first width to the second width being within 10% of a ratio of the first wavelength to the second wavelength. a first interface ; a second interface ; a first plurality of output waveguides , at the first interface; one or more input waveguides , at the second interface; and a free propagation region connecting the first plurality of output waveguides and the one or more input waveguides , a first waveguide, of the first plurality of output waveguides , having a first width, a second waveguide, of the of the first plurality of output waveguides , having a second width, the echelle grating being configured: when light is received at a first wavelength in one of the one or more input waveguides, to direct the light at the first wavelength to the first waveguide; and when light is received at a second wavelength in one of the one or more input waveguides, to direct the light at the second wavelength to the second waveguide, characterised by the first width being at least 5% greater than the second width, and a ratio of the first width to the second width being within 10% of a ratio of the first wavelength to the second wavelength. when light is received at a first wavelength in one of the one or more input waveguides, to direct the light at the first wavelength to the first waveguide; and when light is received at a second wavelength in one of the one or more input waveguides, to direct the light at the second wavelength to the second waveguide, characterised by the first width being at least 5% greater than the second width, and a ratio of the first width to the second width being within 10% of a ratio of the first wavelength to the second wavelength.
Guide system for supply lines for a handling device, particularly for a robot, having a guide base , displaying a guide rail, a deflecting element that is guided along a linear travel path by the guide base and located on a slide that is guided by the guide rail along the travel path, and a chain-like, hose-like or belt-like strand , in or on which the supply lines can be arranged, where the strand , forming a reversing bend , is guided around the deflecting element and displays two branches adjoining the ends of the reversing bend , each having a connecting point located on its free end, specifically a first connecting point that is stationary relative to the guide base and a second connecting point that moves relative to the guide base , and where the deflecting element can travel from a retracted position into an extended position, by means of a tensile force acting on the branch having the second connecting point and against a restoring force, where the restoring force can be generated by a restoring device located on or in the guide base, characterized in that the restoring device displays at least one elastic cord or elastic belt that is guided around a deflecting device located on the guide base , adjacent to the retracted position of the deflecting element , and, adjoining it, a first section that is connected to the deflecting element , and a second section that is connected to the guide base , where the end of the first section of the at least one elastic cord or belt is fastened to the slide and the deflecting device is located on the face end of the guide rail that faces in the direction of the travel path from the extended position of the deflecting element to the retracted position and displays a housing , the side of which facing towards the deflecting element displays an opening for the two sections of the at least one elastic belt or cord.
A terminal connection component, comprising: press-fit terminals ; and terminal metal-fittings , wherein said press-fit terminals have a plate shape in which a taper is disposed at one tip, and said terminal metal-fittings have a plate shape and have a fitting section at one end, wherein said fitting sections of said terminal metal-fittings have a first hole part and a second hole part from said one end in parallel, wherein said first hole part is a rectangular shape, wherein said second hole part is a rectangular shape, and a central portion of one long side near said first hole part is shifted to an interior of said second hole part so that a width (H3) at the central portion (P) of said second hole part is slightly shorter than a thickness (D1) of said press-fit terminals , and wherein said tips of said press-fit terminals are press-fitted to and are connected to said fitting sections of said terminal metal-fittings , and a portion between said first hole part and said second hole part of said fitting section , which serves as an elastic deformation section, is elastically deformed in a thickness direction of said press-fit terminals and biases said press-fit terminal so that said press-fit terminals are surely press-fitted to said fitting sections of said terminal metal-fittings ; wherein said taper, which is disposed at the tip of said press-fit terminal , has round sections having a curvature at both corner portions in an end portion of said plate, and has a portion wherein a thickness of side surface portions of said plate decreases toward said end portion. press-fit terminals ; and terminal metal-fittings , wherein said press-fit terminals have a plate shape in which a taper is disposed at one tip, and said terminal metal-fittings have a plate shape and have a fitting section at one end, wherein said fitting sections of said terminal metal-fittings have a first hole part and a second hole part from said one end in parallel, wherein said first hole part is a rectangular shape, wherein said second hole part is a rectangular shape, and a central portion of one long side near said first hole part is shifted to an interior of said second hole part so that a width (H3) at the central portion (P) of said second hole part is slightly shorter than a thickness (D1) of said press-fit terminals , and wherein said tips of said press-fit terminals are press-fitted to and are connected to said fitting sections of said terminal metal-fittings , and a portion between said first hole part and said second hole part of said fitting section , which serves as an elastic deformation section, is elastically deformed in a thickness direction of said press-fit terminals and biases said press-fit terminal so that said press-fit terminals are surely press-fitted to said fitting sections of said terminal metal-fittings ; wherein said taper, which is disposed at the tip of said press-fit terminal , has round sections having a curvature at both corner portions in an end portion of said plate, and has a portion wherein a thickness of side surface portions of said plate decreases toward said end portion.
A treatment process of a gas containing zero-valent mercury, comprising a mercury oxidation step of oxidizing the zero-valent mercury contained in the gas containing the zero-valent mercury with a first liquid phase containing an alkali metal iodide to take the zero-valent mercury into the first liquid phase, thereby obtaining a second liquid phase containing a divalent mercury ion and an iodide ion; a mercury separation step of separating the divalent mercury ion as mercury sulfide by adjusting the pH of the second liquid phase obtained in the mercury oxidation step with a pH adjustor and adding an alkali metal sulfide; and a first circulation step of circulating a third liquid phase which is obtained by separating the mercury sulfide in the mercury separation step and contains an alkali metal ion and the iodide ion to use the third liquid phase as the first liquid phase in the mercury oxidation step, wherein the alkali metal iodide is at least one selected from potassium iodide, lithium iodide and sodium iodide, and the iodine ion concentration in the first liquid phase is 0.01 to 10% by weight.
A virion comprising a nucleic acid comprising in 5' to 3' direction (i) an adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter selected from AAV promoters p5, p19 and p40, preferably p5 or p19, and even more preferably the combination of the p5 and the p19 promoter; (iii) at least one AAV rep gene coding sequence under the control of said promoter of (ii), wherein the at least one AAV rep gene coding sequence encodes the AAV Rep78 polypeptide of SEQ ID NO: 7 or a sequence being at least 80% identical thereto and/or the AAV Rep68 polypeptide of SEQ ID NO: 6 or a sequence being at least 80% identical thereto and being capable of performing replication, wherein preferably the at least one AAV rep gene coding sequence further encodes the AAV Rep52 polypeptide of SEQ ID NO: 9 or a sequence being at least 80% identical thereto and/or AAV Rep40 polypeptide of SEQ ID NO: 8 or a sequence being at least 80% identical thereto; (iv) a p40 promoter extending from position 1700 until position 2287 of the AAV2 genome according to GenBank entry NC_001401.2 or a sequence being at least 80% identical thereto while retaining the promoter activity; (v) a transgenic coding sequence under the control of said promoter of (iv); (vi) a polyadenylation site; and (vii) an adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; wherein said virion does not comprise an AAV cap gene and/or is not able to express any AAV cap gene products. (i) an adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; (ii) a promoter selected from AAV promoters p5, p19 and p40, preferably p5 or p19, and even more preferably the combination of the p5 and the p19 promoter; (iii) at least one AAV rep gene coding sequence under the control of said promoter of (ii), wherein the at least one AAV rep gene coding sequence encodes the AAV Rep78 polypeptide of SEQ ID NO: 7 or a sequence being at least 80% identical thereto and/or the AAV Rep68 polypeptide of SEQ ID NO: 6 or a sequence being at least 80% identical thereto and being capable of performing replication, wherein preferably the at least one AAV rep gene coding sequence further encodes the AAV Rep52 polypeptide of SEQ ID NO: 9 or a sequence being at least 80% identical thereto and/or AAV Rep40 polypeptide of SEQ ID NO: 8 or a sequence being at least 80% identical thereto; (iv) a p40 promoter extending from position 1700 until position 2287 of the AAV2 genome according to GenBank entry NC_001401.2 or a sequence being at least 80% identical thereto while retaining the promoter activity; (v) a transgenic coding sequence under the control of said promoter of (iv); (vi) a polyadenylation site; and (vii) an adeno-associated virus (AAV) inverted terminal repeat (ITR) sequence; wherein said virion does not comprise an AAV cap gene and/or is not able to express any AAV cap gene products.
A method of facilitating performance of a task on a surface of a material with a user device having a cutting tool comprising a cutting instrument, the method comprising: scanning, by a camera coupled with the user device, the surface of the material to obtain first scanned data of the surface of the material, wherein scanning the surface of the material comprises scanning identifying markers on the material to obtain first scanned data indicating a map of the surface of the material; scanning, by the camera, at least a portion of the surface of the material to obtain second scanned data; evaluating, by a processor, the first scanned data and the second scanned data to determine a position of the camera relative to the surface of the material, wherein evaluating the first scanned data and the second scanned data comprises comparing identifying markers of the second scanned data with the map to determine the position of the camera; determining, by the processor and based on the position of the camera relative to the surface of the material, a position of the cutting instrument of the user device relative to the surface of the material; and adjusting the position of the cutting instrument based on the determined position of the cutting instrument and a target point corresponding to a design plan. scanning, by a camera coupled with the user device, the surface of the material to obtain first scanned data of the surface of the material, wherein scanning the surface of the material comprises scanning identifying markers on the material to obtain first scanned data indicating a map of the surface of the material; scanning, by the camera, at least a portion of the surface of the material to obtain second scanned data; evaluating, by a processor, the first scanned data and the second scanned data to determine a position of the camera relative to the surface of the material, wherein evaluating the first scanned data and the second scanned data comprises comparing identifying markers of the second scanned data with the map to determine the position of the camera; determining, by the processor and based on the position of the camera relative to the surface of the material, a position of the cutting instrument of the user device relative to the surface of the material; and adjusting the position of the cutting instrument based on the determined position of the cutting instrument and a target point corresponding to a design plan.
A tube weld X-ray inspection device, comprising: an X-ray support provided in a length direction so that the X-ray support is capable of being inserted into a tube ; an X-ray source provided at a side of the X-ray support in the length direction thereof, for emitting X-rays; and at least one image plate, IP, fixing part for fixing an image plate in a direction perpendicular to an axis of the length direction of the X-ray support while being spaced a predetermined distance from the X-ray source , the image plate being configured to absorb the X-rays and store the X-rays in a form of energy, characterized in that a plurality of the IP fixing parts are provided such that the plurality of the IP fixing parts are spaced apart from each other by a predetermined distance. an X-ray support provided in a length direction so that the X-ray support is capable of being inserted into a tube ; an X-ray source provided at a side of the X-ray support in the length direction thereof, for emitting X-rays; and at least one image plate, IP, fixing part for fixing an image plate in a direction perpendicular to an axis of the length direction of the X-ray support while being spaced a predetermined distance from the X-ray source , the image plate being configured to absorb the X-rays and store the X-rays in a form of energy, characterized in that a plurality of the IP fixing parts are provided such that the plurality of the IP fixing parts are spaced apart from each other by a predetermined distance.
A blood purification apparatus comprising a holding device capable of holding container bags (B1-B3) that contain liquid for blood purification treatment, such as dialysate, substitution fluid, or anticoagulant, the blood purification apparatus being capable of performing blood purification treatment using the liquid in the container bags, wherein the holding device includes a main body portion a hanger portion that has attachment portions Z to which the container bags can be attached, and movable between a use position in which the container bags are used and a replacement position in which the container bags are replaced, measuring devices (g) capable of measuring the weight of the container bags held by the hanger portion, and a restricting device that restricts attachment and detachment of the container bags to and from the attachment portions when the hanger portion is in the use position.