mhurhangee/patent-ind-claim-en huggingface dataset:
A compound represented by the formula (I): wherein R 1 is a mono- or di-C 1-6 alkyl-carbamoyl group, or a 3- to 6-membered monocyclic non-aromatic heterocyclic group; R 2 is a C 1-6 alkyl-carbonyl group, a C 3-10 cycloalkyl-carbonyl group optionally substituted by 1 to 3 hydroxy groups, a 3- to 14-membered non-aromatic heterocyclylcarbonyl group, a C 1-6 alkoxy-carbonyl group, or a mono- or di-C 1-6 alkyl-carbamoyl group; L 1 is an oxygen atom; L 2 is a methylene group; Ring A is a pyrrolidine ring having no additional substituent or a piperidine ring having no additional substituent; Ring B is a cyclohexane ring having no additional substituent, or a 6-membered monocyclic saturated heterocycle having no additional substituent; and Ring C is a 6-membered monocyclic aromatic heterocycle optionally further substituted by 1 to 3 halogen atoms, or a benzene ring optionally further substituted by 1 to 3 halogen atoms; or a salt thereof. R 1 is a mono- or di-C 1-6 alkyl-carbamoyl group, or a 3- to 6-membered monocyclic non-aromatic heterocyclic group; a mono- or di-C 1-6 alkyl-carbamoyl group, or a 3- to 6-membered monocyclic non-aromatic heterocyclic group; R 2 is a C 1-6 alkyl-carbonyl group, a C 3-10 cycloalkyl-carbonyl group optionally substituted by 1 to 3 hydroxy groups, a 3- to 14-membered non-aromatic heterocyclylcarbonyl group, a C 1-6 alkoxy-carbonyl group, or a mono- or di-C 1-6 alkyl-carbamoyl group; a C 1-6 alkyl-carbonyl group, a C 3-10 cycloalkyl-carbonyl group optionally substituted by 1 to 3 hydroxy groups, a 3- to 14-membered non-aromatic heterocyclylcarbonyl group, a C 1-6 alkoxy-carbonyl group, or a mono- or di-C 1-6 alkyl-carbamoyl group; L 1 is an oxygen atom; L 2 is a methylene group; Ring A is a pyrrolidine ring having no additional substituent or a piperidine ring having no additional substituent; Ring B is a cyclohexane ring having no additional substituent, or a 6-membered monocyclic saturated heterocycle having no additional substituent; and a cyclohexane ring having no additional substituent, or a 6-membered monocyclic saturated heterocycle having no additional substituent; and Ring C is a 6-membered monocyclic aromatic heterocycle optionally further substituted by 1 to 3 halogen atoms, or a benzene ring optionally further substituted by 1 to 3 halogen atoms; a 6-membered monocyclic aromatic heterocycle optionally further substituted by 1 to 3 halogen atoms, or a benzene ring optionally further substituted by 1 to 3 halogen atoms; or a salt thereof.
A p38 kinase inhibitor for use in a method of treating facioscapulohumeral muscular dystrophy (FSHD), the method comprising administering an effective amount of the p38 kinase inhibitor to a subject in need thereof, wherein the p38 kinase inhibitor is characterized by Formula (V'): or a pharmaceutically acceptable salt thereof.
A vacuum device, in particular a turbomolecular pump, comprising a passage , namely an inlet or an outlet, and a flange for a vacuum-tight connection of the passage of the vacuum device to a further flange of a further vacuum device, wherein a carrier for a functional element is arranged in the passage and the carrier comprises at least two arms which connect the carrier to the flange at a respective connection point , wherein the connection points are axially arranged at the level of the flange , characterized in that the flange has a plurality of fastening points which are arranged distributed over a periphery of the flange , the fastening points in particular having passage openings for respective fastening elements to be associated, in that the flange can be fastened to the further flange at the fastening points , and in that all the connection points are arranged in the peripheral direction between two adjacent fastening points in each case. a flange for a vacuum-tight connection of the passage of the vacuum device to a further flange of a further vacuum device, wherein a carrier for a functional element is arranged in the passage and the carrier comprises at least two arms which connect the carrier to the flange at a respective connection point , wherein the connection points are axially arranged at the level of the flange , characterized in that the flange has a plurality of fastening points which are arranged distributed over a periphery of the flange , the fastening points in particular having passage openings for respective fastening elements to be associated, in that the flange can be fastened to the further flange at the fastening points , and in that all the connection points are arranged in the peripheral direction between two adjacent fastening points in each case.
Tip cap assembly adapted to close a fluid passageway extending through a tip of a container of a medical injection system , the tip cap assembly comprising: a rigid outer cap comprising an inner skirt extending proximally and having an outer threaded surface , and an elastomeric inner cap arranged within the outer cap , the inner cap having a protrusion extending proximally and adapted to close the fluid passageway , the tip cap assembly being characterized in that : the outer cap further comprises an outer skirt extending proximally and around the inner skirt so as to define an annular groove between the inner skirt and the outer skirt , characterised in that the outer skirt comprises a proximal member having a projection extending inwardly or a recess depressed outwardly, configured to be engaged with a collar of a barrel of a medical container. a rigid outer cap comprising an inner skirt extending proximally and having an outer threaded surface , and an elastomeric inner cap arranged within the outer cap , the inner cap having a protrusion extending proximally and adapted to close the fluid passageway , the outer cap further comprises an outer skirt extending proximally and around the inner skirt so as to define an annular groove between the inner skirt and the outer skirt , characterised in that the outer skirt comprises a proximal member having a projection extending inwardly or a recess depressed outwardly, configured to be engaged with a collar of a barrel of a medical container.
An oil-based drilling fluid comprising: a base oil continuous phase; an aqueous discontinuous phase; and at least one rheology modifier, the at least one rheology modifier comprising an alkaline-earth diamonoid compound which is a magnesium adamantane carboxylate compound, preferably wherein the magnesium adamantane carboxylate compound comprises a layered morphology. a base oil continuous phase; an aqueous discontinuous phase; and
Method of acquiring images of a terrestrial region Z using a spacecraft in non-geostationary orbit around the Earth along a direction of travel and at a speed of travel relative to the ground V sol , said spacecraft comprising an observation instrument associated with a field of view that is fixed within a spacecraft's frame of reference and forming a ground footprint of length L along the direction of travel, and associated with a spatial resolution R s along the direction of travel, said method being characterized in that it comprises: - a step of observing a portion P 1 of the terrestrial region Z, comprising a step of controlling the attitude of the spacecraft during a time interval of duration α that is greater than R s /V sol , the attitude of the spacecraft being controlled such that the ground footprint of the field of view is kept stationary for the duration α and corresponds to said portion P 1 , and a step of acquisition by the observation instrument of an image of portion P 1 during the time interval of duration α, - a step of modifying the pitch attitude of the spacecraft so as to orient the field of view such that the ground footprint corresponds to a portion P 2 of the terrestrial region Z, portions P 1 and P 2 of the terrestrial region Z being contiguous or at most partially overlapping along the direction of travel, - a step of observing portion P 2 of the terrestrial region Z, and in that the step of modifying the pitch attitude is executed during a time interval of duration β such that the quantity V sol ·(α + β)·1/L is less than 3. - a step of observing a portion P 1 of the terrestrial region Z, comprising a step of controlling the attitude of the spacecraft during a time interval of duration α that is greater than R s /V sol , the attitude of the spacecraft being controlled such that the ground footprint of the field of view is kept stationary for the duration α and corresponds to said portion P 1 , and a step of acquisition by the observation instrument of an image of portion P 1 during the time interval of duration α, - a step of modifying the pitch attitude of the spacecraft so as to orient the field of view such that the ground footprint corresponds to a portion P 2 of the terrestrial region Z, portions P 1 and P 2 of the terrestrial region Z being contiguous or at most partially overlapping along the direction of travel, - a step of observing portion P 2 of the terrestrial region Z,
A method of providing input to a computing device , the computing device comprising a processor , memory , a display having a viewing surface and at least three cameras having respective fields of view, the method comprising the steps of: capturing corresponding images with the cameras; identifying input gestures using the captured images; and interpreting the identified gestures as input to the computing device; wherein at least one of the cameras is orientated such that the respective field of view lies adjacent to the viewing surface of the display; characterized in that said three cameras capture images from the visual band of the electromagnetic spectrum so that the device is useable both indoors and outdoors in direct sunlight; identifying input gestures in the captured images comprises choosing between images captured by either a first camera or a second camera and further using the chosen image to identify input gestures, wherein identifying input gestures in the captured images is further based on images captured by a third of said cameras, wherein choosing between images captured by either the first camera or the second camera comprises comparing information between images captured by the first camera and images captured by the second camera, and wherein comparing information comprises comparing a standard deviation of information contained in an image captured by the first camera to a standard deviation of information contained in an image captured by the second camera. capturing corresponding images with the cameras; identifying input gestures using the captured images; and interpreting the identified gestures as input to the computing device; wherein at least one of the cameras is orientated such that the respective field of view lies adjacent to the viewing surface of the display; characterized in that said three cameras capture images from the visual band of the electromagnetic spectrum so that the device is useable both indoors and outdoors in direct sunlight; identifying input gestures in the captured images comprises choosing between images captured by either a first camera or a second camera and further using the chosen image to identify input gestures, wherein identifying input gestures in the captured images is further based on images captured by a third of said cameras, wherein choosing between images captured by either the first camera or the second camera comprises comparing information between images captured by the first camera and images captured by the second camera, and wherein comparing information comprises comparing a standard deviation of information contained in an image captured by the first camera to a standard deviation of information contained in an image captured by the second camera.
An oligonucleotide structure having a structure represented by the following Structural Formula or Structural Formula . Q-(A m -J) n -X-R-Y-B Structural Formula Q-(J-A m ) n -X-R-Y-B Structural Formula wherein A is a hydrophilic material monomer, B is a hydrophobic material, J is a linker for connecting between m hydrophilic material monomers, or a linker for connecting between m hydrophilic material monomers with oligonucleotides, X and Y are each independently a simple covalent bond or a linker-mediated covalent bond, R is single-stranded or double-stranded oligonucleotide, m is an integer of 1 to 15, and n is an integer of 1 to 10, Q is (L i -Z j ) or P-J 1 -J 2 , L is a ligand specifically bonded to a receptor that promotes target cell internalization through receptor-mediated endocytosis (RME), Z is a linker that mediates a simple covalent bond or a bond between the hydrophilic material monomer in a hydrophilic material block and the ligand, i represents an integer from 0 to 5, preferably, an integer of 0 to 3, and j means 0 or 1, provided that when i is 0, j is necessarily 0, P means an amine group or a polyhistidine group, and J 1 and J 2 are independently linkers that mediate a simple covalent bond, or a bond between the amine group or the polyhistidine group with the hydrophilic material. wherein A is a hydrophilic material monomer, B is a hydrophobic material, J is a linker for connecting between m hydrophilic material monomers, or a linker for connecting between m hydrophilic material monomers with oligonucleotides, X and Y are each independently a simple covalent bond or a linker-mediated covalent bond, R is single-stranded or double-stranded oligonucleotide, m is an integer of 1 to 15, and n is an integer of 1 to 10, Q is (L i -Z j ) or P-J 1 -J 2 , L is a ligand specifically bonded to a receptor that promotes target cell internalization through receptor-mediated endocytosis (RME), Z is a linker that mediates a simple covalent bond or a bond between the hydrophilic material monomer in a hydrophilic material block and the ligand, i represents an integer from 0 to 5, preferably, an integer of 0 to 3, and j means 0 or 1, provided that when i is 0, j is necessarily 0, P means an amine group or a polyhistidine group, and J 1 and J 2 are independently linkers that mediate a simple covalent bond, or a bond between the amine group or the polyhistidine group with the hydrophilic material.
A device for controlling pests in a plant cultivation room , comprising a spray means having nozzles for spraying a liquid chemical containing a pest control agent inside a plant cultivation room ; wherein piping headers configured to be installed in an upper space inside said plant cultivation room; said nozzles are attached to each of said piping headers at certain intervals; diameters of droplets sprayed from said nozzles are not more than 100μm, and an average particle diameter of said droplets is not less than 10μm nor more than 30μm; said nozzles are so disposed that sprays injected from said nozzles uniformly fill an entire region inside said plant cultivation room; a control device for spraying said liquid chemical from said nozzles so that a humidity inside said plant cultivation room becomes not less than 90% nor more than 100% is provided; and through a change-over valve , a liquid chemical-side branch pipe and a water-side branch pipe are coupled to a liquid flow pipe connected to said nozzle-attached piping headers to supply water to said nozzles as cleaning water after said liquid chemical is supplied to said nozzles and selectively use said nozzles as fine mist spraying nozzles for cooling the air inside said plant cultivation room and as nozzles for humidifying said air inside said plant cultivation room. piping headers configured to be installed in an upper space inside said plant cultivation room; said nozzles are attached to each of said piping headers at certain intervals; diameters of droplets sprayed from said nozzles are not more than 100μm, and an average particle diameter of said droplets is not less than 10μm nor more than 30μm; said nozzles are so disposed that sprays injected from said nozzles uniformly fill an entire region inside said plant cultivation room; a control device for spraying said liquid chemical from said nozzles so that a humidity inside said plant cultivation room becomes not less than 90% nor more than 100% is provided; and through a change-over valve , a liquid chemical-side branch pipe and a water-side branch pipe are coupled to a liquid flow pipe connected to said nozzle-attached piping headers to supply water to said nozzles as cleaning water after said liquid chemical is supplied to said nozzles and selectively use said nozzles as fine mist spraying nozzles for cooling the air inside said plant cultivation room and as nozzles for humidifying said air inside said plant cultivation room.
A composition comprising arsenic trioxide and Cu 2+ ions, for use in treating a disease selected from the group consisting of a neoplastic disease, an autoimmune disease, an inflammatory disease and various forms of multiple sclerosis (MS), wherein the amount of arsenic trioxide in one daily dose is between 0.01 and 0.10 mg/kg/day and wherein the amount of Cu2+ in one daily dose is between 0.05 μmol/kg and 2 μmol/kg of Cu 2+ .
Bicycle trainer which excludes a flywheel and comprises a seat, handlebars, rotatable pedals , a computer controller , a virtual variable-ratio transmission system and an electronically variable brake acting directly or indirectly on the rotatable pedals with a braking resistance, wherein the electronically variable brake is controlled by the computer controller , wherein the controller uses as one of its inputs a setting of the virtual variable-ratio transmission system , wherein the controller determines a predetermined setting of the braking resistance of the brake, wherein the predetermined setting is variable and depends on parameters which can be selected to reflect cycling conditions and comprising at least one of a road, wind conditions and a cyclist, wherein the predetermined setting of the braking resistance of the brake also depends on a change of setting of the virtual variable-ratio transmission system so as to simulate a level of inertia as experienced by an outdoor cyclist if the outdoor cyclist changes the setting of the variable-ratio transmission system , characterized in that in order to simulate the feeling of the cyclist during changing gear if the cyclist changes the setting of the virtual variable transmission system , the predetermined setting of the braking resistance is time variable with variations with a predetermined frequency during a change of setting of the virtual variable ratio transmission system corresponding to a virtual chain derailing from one sprocket wheel to another.
A method performed by a Radio Access Network, RAN, node , for managing communication on a first network slice in a communications network , wherein the communications network comprises partitioned sets of functionalities, wherein a first set of functionalities belongs to the first network slice, and which first set of functionalities is at least partly separated from another set of functionalities out of a total set of functionalities in the communications network , the method comprising: - receiving , from a Core Network, CN, node , information regarding requested resources for a first network slice identified by a network slice identifier, - determining that the received information does not correspond to a Service Level Agreement, SLA, for the first network slice, wherein the determining comprises comparing the received information for the first network slice with the SLA for the first network slice. - receiving , from a Core Network, CN, node , information regarding requested resources for a first network slice identified by a network slice identifier, - determining that the received information does not correspond to a Service Level Agreement, SLA, for the first network slice, wherein the determining comprises comparing the received information for the first network slice with the SLA for the first network slice.
A fan nacelle for an aircraft gas turbine engine , the nacelle comprising: an aft nacelle portion comprising a radially outer surface and a radially inner surface , the radially outer and inner surfaces defining an internal cavity therebetween; a plurality of aft nacelle segments translatable along a translation vector (V) having an axial component, the aft nacelle portion comprising a plurality of nacelle fingers extending generally axially between adjacent segments , wherein the aft nacelle segment is configured to translate between a forward deployed position in which the nacelle defines a first primary fan nozzle exit area (A 1 ) and a clean position in which the nacelle defines a second primary fan nozzle exit area (A 2 ) less than the first primary fan nozzle exit area (A 1 ), wherein in the forward deployed position, the aft nacelle segment is at least partly located within the internal cavity , characterised in that each segment has spaced parallel sides extending in a direction parallel to the translation vector (V) of the respective segment, wherein sides of each nacelle finger extend in a direction parallel to the adjacent segment side . an aft nacelle portion comprising a radially outer surface and a radially inner surface , the radially outer and inner surfaces defining an internal cavity therebetween; a plurality of aft nacelle segments translatable along a translation vector (V) having an axial component, the aft nacelle portion comprising a plurality of nacelle fingers extending generally axially between adjacent segments , wherein the aft nacelle segment is configured to translate between a forward deployed position in which the nacelle defines a first primary fan nozzle exit area (A 1 ) and a clean position in which the nacelle defines a second primary fan nozzle exit area (A 2 ) less than the first primary fan nozzle exit area (A 1 ), wherein in the forward deployed position, the aft nacelle segment is at least partly located within the internal cavity , characterised in that each segment has spaced parallel sides extending in a direction parallel to the translation vector (V) of the respective segment, wherein sides of each nacelle finger extend in a direction parallel to the adjacent segment side .