A gel formulation consisting of a gel, a water soluble nano-form of curcumin, a water soluble nano-form of an ethanolic extract of Emblica officinalis and a water soluble nano-form of an ethanolic extract of Camellia sinensis, wherein said gel is Aloe vera gel or silicon, and wherein said water soluble nano-forms are obtainable as follows: - nano-form of curcumin: ∘ providing curcumin; ∘ preparing a 5-10% solution of said curcumin in 1 M NaOH with continuous mixing; ∘ neutralizing the obtained solution with 5 N HCl and adjusting the pH to 5.5; ∘ sonicating the obtained solution for 5 hours with an amplitude of 25 kHz while maintaining the temperature below 30°C; - nano-form of Emblica officinalis: ∘ adding dried and crushed plant, said plant is fruit, to an ethanol solution and keeping over magnetic stirrer for about 20 hrs at 60°C; ∘ separating the ethanolic extract by centrifugation at 8000 rpm for 15 min; ∘ allowing the supernatant to dry in rotary evaporator or in oven at 30°C-85°C; ∘ preparing the solution of the desired concentration by dissolving the dried extract in a 10%-20% ethanol solution and sonicating said solution for 15 min to 5 hours with an amplitude of at least 25 kHz at ice temperature; ∘ evaporating the excess of ethanol to form a water soluble plant extract; - nano-form of Camellia sinensis: ∘ same steps as for said nano-form of Emblica officinalis, but wherein said plant are leaves. - nano-form of curcumin: ∘ providing curcumin; ∘ preparing a 5-10% solution of said curcumin in 1 M NaOH with continuous mixing; ∘ neutralizing the obtained solution with 5 N HCl and adjusting the pH to 5.5; ∘ sonicating the obtained solution for 5 hours with an amplitude of 25 kHz while maintaining the temperature below 30°C; ∘ providing curcumin; ∘ preparing a 5-10% solution of said curcumin in 1 M NaOH with continuous mixing; ∘ neutralizing the obtained solution with 5 N HCl and adjusting the pH to 5.5; ∘ sonicating the obtained solution for 5 hours with an amplitude of 25 kHz while maintaining the temperature below 30°C; - nano-form of Emblica officinalis: ∘ adding dried and crushed plant, said plant is fruit, to an ethanol solution and keeping over magnetic stirrer for about 20 hrs at 60°C; ∘ separating the ethanolic extract by centrifugation at 8000 rpm for 15 min; ∘ allowing the supernatant to dry in rotary evaporator or in oven at 30°C-85°C; ∘ preparing the solution of the desired concentration by dissolving the dried extract in a 10%-20% ethanol solution and sonicating said solution for 15 min to 5 hours with an amplitude of at least 25 kHz at ice temperature; ∘ evaporating the excess of ethanol to form a water soluble plant extract; ∘ adding dried and crushed plant, said plant is fruit, to an ethanol solution and keeping over magnetic stirrer for about 20 hrs at 60°C; ∘ separating the ethanolic extract by centrifugation at 8000 rpm for 15 min; ∘ allowing the supernatant to dry in rotary evaporator or in oven at 30°C-85°C; ∘ preparing the solution of the desired concentration by dissolving the dried extract in a 10%-20% ethanol solution and sonicating said solution for 15 min to 5 hours with an amplitude of at least 25 kHz at ice temperature; ∘ evaporating the excess of ethanol to form a water soluble plant extract; - nano-form of Camellia sinensis: ∘ same steps as for said nano-form of Emblica officinalis, but wherein said plant are leaves. <EOS>