mhurhangee/patent-ind-claim-en huggingface dataset:
A fusion antibody comprising: (a) an immunoglobulin that crosses a blood brain barrier (BBB) by binding to an extracellular domain of a human insulin receptor, wherein the immunoglobulin comprises an immunoglobulin heavy chain and an immunoglobulin light chain; and (b) an iduronate-2-sulfatase, wherein the amino terminus of the iduronate-2-sulfatase is covalently linked to the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain, thereby forming a fusion protein; (c) a linker between the amino terminus of the iduronate-2-sulfatase and the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain; wherein the fusion antibody crosses the blood brain barrier (BBB) and catalyzes hydrolysis of 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate or heparin, wherein the fusion antibody comprises a post-translational cysteine to formylglycine modification at the position corresponding to Cys-59 of the iduronate-2-sulfatase enzyme, wherein the immunoglobulin heavy chain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:1, a CDR2 comprising the amino acid sequence of SEQ ID NO:2, and a CDR3 comprising the amino acid sequence of SEQ ID NO:3, and wherein the immunoglobulin light chain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:4, a CDR2 comprising the amino acid sequence of SEQ ID NO:5, and a CDR3 comprising the amino acid sequence of SEQ ID NO:6. (a) an immunoglobulin that crosses a blood brain barrier (BBB) by binding to an extracellular domain of a human insulin receptor, wherein the immunoglobulin comprises an immunoglobulin heavy chain and an immunoglobulin light chain; and (b) an iduronate-2-sulfatase, wherein the amino terminus of the iduronate-2-sulfatase is covalently linked to the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain, thereby forming a fusion protein; (c) a linker between the amino terminus of the iduronate-2-sulfatase and the carboxy terminus of the amino acid sequence of the immunoglobulin heavy chain; wherein the fusion antibody comprises a post-translational cysteine to formylglycine modification at the position corresponding to Cys-59 of the iduronate-2-sulfatase enzyme, wherein the immunoglobulin heavy chain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:1, a CDR2 comprising the amino acid sequence of SEQ ID NO:2, and a CDR3 comprising the amino acid sequence of SEQ ID NO:3, and wherein the immunoglobulin light chain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:4, a CDR2 comprising the amino acid sequence of SEQ ID NO:5, and a CDR3 comprising the amino acid sequence of SEQ ID NO:6.
A method for manufacturing carbonized particles or agglomerates, wherein said method is continuous or semi-continuous, and wherein said carbonized particles or agglomerates preferably are in the form of a carbon powder, most preferred also electrically conductive, comprising the following steps: a) providing a dried raw material in powder form emanating from a ligno-cellulosic material, preferably lignin, and suspending and/or diluting said raw material in a fluidic medium, wherein the fluidic medium is an inert gas or an inert gas mixture, and b) carbonization of the raw material in said fluidic medium, wherein the carbonization comprises conveying the raw material in the fluidic medium into and through a hot chamber, preferably a furnace system, and continuously thermally treating said raw material in the fluidic medium, at a temperature range of from 900 to 1800 °C, during a time period of from one millisecond up to a quarter of an hour thus providing one or more carbonized particles or agglomerates, preferably in the form of a carbon powder. a) providing a dried raw material in powder form emanating from a ligno-cellulosic material, preferably lignin, and suspending and/or diluting said raw material in a fluidic medium, wherein the fluidic medium is an inert gas or an inert gas mixture, and b) carbonization of the raw material in said fluidic medium, wherein the carbonization comprises conveying the raw material in the fluidic medium into and through a hot chamber, preferably a furnace system, and continuously thermally treating said raw material in the fluidic medium, at a temperature range of from 900 to 1800 °C, during a time period of from one millisecond up to a quarter of an hour thus providing one or more carbonized particles or agglomerates, preferably in the form of a carbon powder.
A method comprising: receiving, by a wireless device , one or more radio resource control messages indicating configuration parameters for multi-stage downlink control information, DCI; receiving first-stage DCI, of the multi-stage DCI, comprising: an indication of allocated resources; and information associated with second-stage DCI of the multi-stage DCI; receiving, via the allocated resources, data; and determining to skip a scheduled transmission associated with the multi-stage DCI, wherein the determining to skip is based on at least one of: the information associated with the second-stage DCI indicating an absence of the second-stage DCI; or an unsuccessful decoding of the second-stage DCI. receiving, by a wireless device , one or more radio resource control messages indicating configuration parameters for multi-stage downlink control information, DCI; receiving first-stage DCI, of the multi-stage DCI, comprising: an indication of allocated resources; and information associated with second-stage DCI of the multi-stage DCI; an indication of allocated resources; and information associated with second-stage DCI of the multi-stage DCI; receiving, via the allocated resources, data; and determining to skip a scheduled transmission associated with the multi-stage DCI, wherein the determining to skip is based on at least one of: the information associated with the second-stage DCI indicating an absence of the second-stage DCI; or an unsuccessful decoding of the second-stage DCI. the information associated with the second-stage DCI indicating an absence of the second-stage DCI; or an unsuccessful decoding of the second-stage DCI.
Electric switch of the normally closed type comprising: - a housing comprising an upper part made of insulating material and a complementary lower part that supports a fixed internal contact track; - an internal contact blade that is supported by the upper part and that is resiliently deformable in order to assume: * a bottom rest position (NC), in which it is in downwards resilient abutment on the lower fixed contact track in order to establish an electric switching way; * a first high non-stable position (NOi), in which the electric switching way is interrupted; and * a second high stable position (NOs), in which the electric switching way is interrupted and in which the internal contact blade is locked by retractable locking means ; - a actuator to control the deformation of the internal contact blade , which actuator, from a rest position in which the internal contact blade is in its bottom rest position and towards which it is resiliently returned, is pivotably mounted, about a horizontal axis (A), between: * a first angular actuating position, in which the internal contact blade is in its first high non-stable position; and * a second angular actuating position, in which the internal contact blade is in its second high stable position. - a housing comprising an upper part made of insulating material and a complementary lower part that supports a fixed internal contact track; - an internal contact blade that is supported by the upper part and that is resiliently deformable in order to assume: * a bottom rest position (NC), in which it is in downwards resilient abutment on the lower fixed contact track in order to establish an electric switching way; * a first high non-stable position (NOi), in which the electric switching way is interrupted; and * a second high stable position (NOs), in which the electric switching way is interrupted and in which the internal contact blade is locked by retractable locking means ; * a bottom rest position (NC), in which it is in downwards resilient abutment on the lower fixed contact track in order to establish an electric switching way; * a first high non-stable position (NOi), in which the electric switching way is interrupted; and * a second high stable position (NOs), in which the electric switching way is interrupted and in which the internal contact blade is locked by retractable locking means ; - a actuator to control the deformation of the internal contact blade , which actuator, from a rest position in which the internal contact blade is in its bottom rest position and towards which it is resiliently returned, is pivotably mounted, about a horizontal axis (A), between: * a first angular actuating position, in which the internal contact blade is in its first high non-stable position; and * a second angular actuating position, in which the internal contact blade is in its second high stable position. * a first angular actuating position, in which the internal contact blade is in its first high non-stable position; and * a second angular actuating position, in which the internal contact blade is in its second high stable position.
A method for providing access to a location secured by an electronically activated locking mechanism , the method comprising the steps of: detecting a geographical position of a mobile device ; determining that the detected geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism ; receiving a command from a user of the mobile device to unlock the locking mechanism and transmitting a signal causing the electronically activated locking mechanism to unlock when it is determined that the geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism ; initiating a recording from a camera of the mobile device in response to determining that the detected geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism; transmitting a further signal causing the electronically activated locking mechanism to lock; and automatically stopping the recording from the camera of the mobile device in response to the further signal causing the electronically activated locking mechanism to lock. detecting a geographical position of a mobile device ; determining that the detected geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism ; receiving a command from a user of the mobile device to unlock the locking mechanism and transmitting a signal causing the electronically activated locking mechanism to unlock when it is determined that the geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism ; initiating a recording from a camera of the mobile device in response to determining that the detected geographical position of the mobile device is proximate to the location secured by the electronically activated locking mechanism; transmitting a further signal causing the electronically activated locking mechanism to lock; and automatically stopping the recording from the camera of the mobile device in response to the further signal causing the electronically activated locking mechanism to lock.
A method of joining a client device to an existing call, comprising: detecting , using a sensing component (110; 1604), a physical gesture between a first client device a second client device , wherein the first client device is participating in a call at the time of detection of the physical gesture and the second client device is not participating in the call at the time of the detection of the physical gesture; responsive to the detection of the physical gesture, initiating participation of the second client device in the call; the method is characterized by : identifying a gesture type of the physical gesture from a set of possible gesture types, wherein the possible gesture types in the set correspond to differing respective actions pertaining to the call; and causing a particular action pertaining to the call corresponding to the gesture type responsive to the detection of the physical gesture and identification of the gesture type, wherein a first possible gesture type corresponds to a transfer action where the call is transferred from the client device to the second client device , and wherein a second possible gesture type corresponds to a conference action where the second client device is joined to the call while the client device continues to participate in the call. detecting , using a sensing component (110; 1604), a physical gesture between a first client device a second client device , wherein the first client device is participating in a call at the time of detection of the physical gesture and the second client device is not participating in the call at the time of the detection of the physical gesture; responsive to the detection of the physical gesture, initiating participation of the second client device in the call; the method is characterized by : identifying a gesture type of the physical gesture from a set of possible gesture types, wherein the possible gesture types in the set correspond to differing respective actions pertaining to the call; and causing a particular action pertaining to the call corresponding to the gesture type responsive to the detection of the physical gesture and identification of the gesture type, identifying a gesture type of the physical gesture from a set of possible gesture types, wherein the possible gesture types in the set correspond to differing respective actions pertaining to the call; and causing a particular action pertaining to the call corresponding to the gesture type responsive to the detection of the physical gesture and identification of the gesture type, wherein a first possible gesture type corresponds to a transfer action where the call is transferred from the client device to the second client device , and wherein a second possible gesture type corresponds to a conference action where the second client device is joined to the call while the client device continues to participate in the call.
A photodynamic therapy device, comprising: a light emitting unit including a plurality of light sources each belonging to any one of a plurality of groups; a photodetector configured to output an electrical signal corresponding to an amount of light received from one or more of the plurality of light sources; a light emission control unit configured to sequentially cause the plurality of light sources to emit light for each group; the photodynamic therapy device being characterised by further comprising: a computing unit configured to calculate, based on a distance coefficient related to a distance between the photodetector and one or more of the plurality of light sources belonging to the each group, and on a value of the electrical signal output by the photodetector in accordance with light emitted from the one or more of the plurality of light sources belonging to the each group, a group light amount value related to a light amount of the one or more of the plurality of light sources belonging to the each group. a light emitting unit including a plurality of light sources each belonging to any one of a plurality of groups; a photodetector configured to output an electrical signal corresponding to an amount of light received from one or more of the plurality of light sources; a light emission control unit configured to sequentially cause the plurality of light sources to emit light for each group; the photodynamic therapy device being characterised by further comprising: a computing unit configured to calculate, based on a distance coefficient related to a distance between the photodetector and one or more of the plurality of light sources belonging to the each group, and on a value of the electrical signal output by the photodetector in accordance with light emitted from the one or more of the plurality of light sources belonging to the each group, a group light amount value related to a light amount of the one or more of the plurality of light sources belonging to the each group.
An optical touch screen apparatus , comprising: an array including a plurality of light sensing pixels configured to sense light, the plurality of light sensing pixels being arranged in a plurality of columns and a plurality of rows; a gate driver configured to supply each of the light sensing pixels with a gate voltage using a plurality of gate lines (GATE1, GATE2, GATEn) and a reset signal using a reset line (RESET), the plurality of gate lines (GATE1, GATE2, GATEn) and the reset line (RESET) extending in a row direction; and a signal output unit configured to receive a light sensing signal from each of the plurality of light sensing pixels and to output a data signal, wherein the plurality of gate lines (GATE1, GATE2, GATEn) are arranged row by row such that each of the plurality of gate lines (GATE1, GATE2, GATEn) and the reset line (RESET) is connected to the gate driver , and characterized in that the reset line (RESET) is connected to all of the plurality of light sensing pixels arranged in the plurality of rows in the optical touch screen apparatus such that all of the plurality of light sensing pixels in the optical touch screen apparatus is reset simultaneously. an array including a plurality of light sensing pixels configured to sense light, the plurality of light sensing pixels being arranged in a plurality of columns and a plurality of rows; a gate driver configured to supply each of the light sensing pixels with a gate voltage using a plurality of gate lines (GATE1, GATE2, GATEn) and a reset signal using a reset line (RESET), the plurality of gate lines (GATE1, GATE2, GATEn) and the reset line (RESET) extending in a row direction; and a signal output unit configured to receive a light sensing signal from each of the plurality of light sensing pixels and to output a data signal, wherein the plurality of gate lines (GATE1, GATE2, GATEn) are arranged row by row such that each of the plurality of gate lines (GATE1, GATE2, GATEn) and the reset line (RESET) is connected to the gate driver , and characterized in that the reset line (RESET) is connected to all of the plurality of light sensing pixels arranged in the plurality of rows in the optical touch screen apparatus such that all of the plurality of light sensing pixels in the optical touch screen apparatus is reset simultaneously.
A mirabegron-containing pharmaceutical preparation characterized by containing a spray-dried granulated product consisting of mirabegron, hypromellose, and polyvinylpyrrolidone, wherein the spray-dried granulated product contains 100% or more by mass of the hypromellose and the polyvinylpyrrolidone in total with respect to a content of the mirabegron.
System for determining a prescription for an eye of a person, the system being configured to communicate with a mobile device , comprising: - at least one first light source adapted to illuminate the eye with first light having a first optical wavelength; - at least one second light source adapted to illuminate the eye with second light having a second optical wavelength different from the first wavelength; and - a calculation module comprising a memory and a processor arranged to execute a program instructions stored in the memory to: o measure the photorefraction of the eye at the first wavelength based on at least one picture of the eye recorded when illuminating the eye with first light ; o measure the photorefraction of the eye at the second wavelength based on at least one picture of the eye recorded when illuminating the eye with second light ; o determine the prescription for the eye based on the measured photorefraction at the first wavelength and the measured photorefraction at the second wavelength. - at least one first light source adapted to illuminate the eye with first light having a first optical wavelength; - at least one second light source adapted to illuminate the eye with second light having a second optical wavelength different from the first wavelength; and - a calculation module comprising a memory and a processor arranged to execute a program instructions stored in the memory to: o measure the photorefraction of the eye at the first wavelength based on at least one picture of the eye recorded when illuminating the eye with first light ; o measure the photorefraction of the eye at the second wavelength based on at least one picture of the eye recorded when illuminating the eye with second light ; o determine the prescription for the eye based on the measured photorefraction at the first wavelength and the measured photorefraction at the second wavelength. o measure the photorefraction of the eye at the first wavelength based on at least one picture of the eye recorded when illuminating the eye with first light ; o measure the photorefraction of the eye at the second wavelength based on at least one picture of the eye recorded when illuminating the eye with second light ; o determine the prescription for the eye based on the measured photorefraction at the first wavelength and the measured photorefraction at the second wavelength.
A method for producing a shaped article comprising a step of 3D printing a composition, wherein the composition comprises: a pre-polymer comprising a polymeric unit of the general formula (-A-B-) n , wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1; wherein the content of grafted anhydride in the composition is less than 0.05mol/mol of polyacid, as measured by nuclear magnetic resonance (NMR).
Method for the activation of defence mechanisms in plants comprising the steps of: mixing vegetable oil and ozone to provide ozonized oil, wherei the obtained oil comprises ozone in a quantity ranging from 1% to 10% of the total weight; mixing said ozonized oil with water to provide ozonized oil in water in a quantity ranging from 1% to 15% of the total weight, and an emulsifier in a quantity ranging from 5% to 10% of the total weight to provide a compound; spraying said compound to said plants. mixing vegetable oil and ozone to provide ozonized oil, wherei the obtained oil comprises ozone in a quantity ranging from 1% to 10% of the total weight; mixing said ozonized oil with water to provide ozonized oil in water in a quantity ranging from 1% to 15% of the total weight, and an emulsifier in a quantity ranging from 5% to 10% of the total weight to provide a compound; spraying said compound to said plants.