A reloadable system for treating tissue, comprising: a clip assembly including a pair of clip arms , each of the clip arms extending from a proximal end to a distal end , the proximal end of each of the clip arms being slidably received within a channel of a capsule to be moved between a tissue receiving configuration, in which distal ends of the clip arms are biased so as to be separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another and constrained by the capsule ; a cartridge including a groove therein, the groove sized and shaped for housing the clip assembly , the cartridge including a proximal opening open to an exterior of the cartridge in communication with the groove ; and an applicator having a distal portion insertable through the opening of the cartridge to be releasably coupled to the clip assembly to move the clip assembly between the tissue receiving configuration and the tissue clipping configuration, the applicator including a control member connectable to the proximal end of each of the clip arms and a locking sleeve coupleable to a proximal end of the capsule via a deflectable tab defined along a length of the locking sleeve from a free distal end to a proximal end connected to the remaining portion of the locking sleeve so that the deflectable tab is deflectable relative to the remaining portion, the deflectable tab including an engaging structure configured to engage a corresponding engaging structure at the proximal end of the capsule ; characterized in that the deflectable tab (184, 284; 324) includes a releasing structure proximal of the engaging structure , the releasing structure being engageable with a portion of the control member to deflect the deflectable tab and disengage the engaging structure of the locking sleeve from the corresponding engaging structure of the capsule . a clip assembly including a pair of clip arms , each of the clip arms extending from a proximal end to a distal end , the proximal end of each of the clip arms being slidably received within a channel of a capsule to be moved between a tissue receiving configuration, in which distal ends of the clip arms are biased so as to be separated from one another, and a tissue clipping configuration, in which distal ends of the clip arms are moved toward one another and constrained by the capsule ; a cartridge including a groove therein, the groove sized and shaped for housing the clip assembly , the cartridge including a proximal opening open to an exterior of the cartridge in communication with the groove ; and an applicator having a distal portion insertable through the opening of the cartridge to be releasably coupled to the clip assembly to move the clip assembly between the tissue receiving configuration and the tissue clipping configuration, the applicator including a control member connectable to the proximal end of each of the clip arms and a locking sleeve coupleable to a proximal end of the capsule via a deflectable tab defined along a length of the locking sleeve from a free distal end to a proximal end connected to the remaining portion of the locking sleeve so that the deflectable tab is deflectable relative to the remaining portion, the deflectable tab including an engaging structure configured to engage a corresponding engaging structure at the proximal end of the capsule ; characterized in that the deflectable tab (184, 284; 324) includes a releasing structure proximal of the engaging structure , the releasing structure being engageable with a portion of the control member to deflect the deflectable tab and disengage the engaging structure of the locking sleeve from the corresponding engaging structure of the capsule . <EOS>