Apparatus for treating a subject with a diseased mitral valve, the apparatus comprising: a mitral annulus repair device configured to be implanted within a left atrium of the subject such that no portion of the mitral annulus repair device extends through the subject's mitral valve, the mitral annulus repair device comprising: a ring ; and a frame extending upwardly from the ring , the frame being configured to anchor the mitral annulus repair device within the left atrium, prior to the tissue ingrowth to the mitral annulus repair device occuring by the frame expanding against inner walls and a roof of the left atrium, the frame comprising a plurality of struts that define a plurality of cells , a first portion of the frame, which extends from the ring until a height of at least 5 mm from the ring , being covered in a fabric skirt that is configured to encourage tissue ingrowth thereto, the mitral annulus repair device being configured to generate ingrowth of the tissue of the subject to the mitral annulus repair device , such that there is substantial tissue ingrowth with respect to the frame and/or the fabric skirt, but there is not substantial tissue ingrowth with respect to the ring , and the ring being adjustable in size and the ring being configured to reduce a diameter of the subject's native mitral annulus by a diameter of the ring being reduced, subsequent to tissue ingrowth to the frame and/or the fabric skirt having occurred. a mitral annulus repair device configured to be implanted within a left atrium of the subject such that no portion of the mitral annulus repair device extends through the subject's mitral valve, the mitral annulus repair device comprising: a ring ; and a frame extending upwardly from the ring , the frame being configured to anchor the mitral annulus repair device within the left atrium, prior to the tissue ingrowth to the mitral annulus repair device occuring by the frame expanding against inner walls and a roof of the left atrium, the frame comprising a plurality of struts that define a plurality of cells , a first portion of the frame, which extends from the ring until a height of at least 5 mm from the ring , being covered in a fabric skirt that is configured to encourage tissue ingrowth thereto, the mitral annulus repair device being configured to generate ingrowth of the tissue of the subject to the mitral annulus repair device , such that there is substantial tissue ingrowth with respect to the frame and/or the fabric skirt, but there is not substantial tissue ingrowth with respect to the ring , and the ring being adjustable in size and the ring being configured to reduce a diameter of the subject's native mitral annulus by a diameter of the ring being reduced, subsequent to tissue ingrowth to the frame and/or the fabric skirt having occurred. a ring ; and a frame extending upwardly from the ring , the frame being configured to anchor the mitral annulus repair device within the left atrium, prior to the tissue ingrowth to the mitral annulus repair device occuring by the frame expanding against inner walls and a roof of the left atrium, the frame comprising a plurality of struts that define a plurality of cells , a first portion of the frame, which extends from the ring until a height of at least 5 mm from the ring , being covered in a fabric skirt that is configured to encourage tissue ingrowth thereto, the mitral annulus repair device being configured to generate ingrowth of the tissue of the subject to the mitral annulus repair device , such that there is substantial tissue ingrowth with respect to the frame and/or the fabric skirt, but there is not substantial tissue ingrowth with respect to the ring , and the ring being adjustable in size and the ring being configured to reduce a diameter of the subject's native mitral annulus by a diameter of the ring being reduced, subsequent to tissue ingrowth to the frame and/or the fabric skirt having occurred. <EOS>