An indwelling, wearable biosensor device for the continuous detection and monitoring of at least one analyte in a patient's fluid sample, the device comprising: a microneedle array , the microneedle array comprising a plurality of microneedles (14A - 14L) constructed of at least one polymeric material, wherein the plurality of microneedles (14A - 14L) is configured to be imbedded in an epidermal tissue of a patient such that the plurality of microneedles is in continuous contact with a fluid sample of a patient; a plurality of analyte sensors (20A - 20E) operatively associated with the polymeric material of each microneedle of the plurality of microneedles (14A - 14L), wherein fluorophore sensor(s) are contained within and/or coated on each of the microneedles (14A - 14L) of the microneedle array , the plurality of analyte sensors (20A - 20E) generating signals indicative of a concentration of at least one analyte present in the fluid sample of the patient; a substrate having a top portion and a bottom portion , wherein the microneedle array is permanently attached to the bottom portion of the substrate ; and a detector , wherein the detector comprises circuitry for receiving the signals generated by the plurality of analyte sensors (20A - 20E), calculating the concentration of the at least one analyte present in the fluid sample of the patient, and transmitting the concentration to an external device for diagnosis and evaluation of proposed treatments, characterized in that at least one surface of each microneedle of the plurality of microneedles (14A-14L) comprises at least one anti-wound healing compound (35A - 35D) which inhibits a wound healing process when the microneedle array is embedded in the epidermal tissue of the patient. a microneedle array , the microneedle array comprising a plurality of microneedles (14A - 14L) constructed of at least one polymeric material, wherein the plurality of microneedles (14A - 14L) is configured to be imbedded in an epidermal tissue of a patient such that the plurality of microneedles is in continuous contact with a fluid sample of a patient; a plurality of analyte sensors (20A - 20E) operatively associated with the polymeric material of each microneedle of the plurality of microneedles (14A - 14L), wherein fluorophore sensor(s) are contained within and/or coated on each of the microneedles (14A - 14L) of the microneedle array , the plurality of analyte sensors (20A - 20E) generating signals indicative of a concentration of at least one analyte present in the fluid sample of the patient; a substrate having a top portion and a bottom portion , wherein the microneedle array is permanently attached to the bottom portion of the substrate ; and a detector , wherein the detector comprises circuitry for receiving the signals generated by the plurality of analyte sensors (20A - 20E), calculating the concentration of the at least one analyte present in the fluid sample of the patient, and transmitting the concentration to an external device for diagnosis and evaluation of proposed treatments, characterized in that at least one surface of each microneedle of the plurality of microneedles (14A-14L) comprises at least one anti-wound healing compound (35A - 35D) which inhibits a wound healing process when the microneedle array is embedded in the epidermal tissue of the patient. <EOS>