mhurhangee/patent-ind-claim-en huggingface dataset:
A single dose vaccine formulation for use in the prevention against typhoid fever caused by Salmonella typhi, comprising a capsular Vi-polysaccharide (ViPs) of Salmonella typhi conjugated to a carrier protein of tetanus toxoid as vaccine antigen without any linker molecule ADH , wherein a single dose of the vaccine formulation is sufficient to elicit required T-dependent immune response against S. typhi including in children below 2 years of age, wherein the vaccine comprises 5 μg to 25 μg of said Salmonella typhi Vi-polysaccharide-carrier protein conjugate vaccine antigen obtained by a method comprising : a. Fed-batch mode of cultivation to obtain purified ViPs with a feed medium, the feed medium comprising feeding a solution containing glucose at a range of 1 to 2 mg/mL concentration at a pH maintained in the range of 6.90 to 7.20 and dissolved oxygen level maintained between 40%-60%, wherein ammonia solution (50%) was supplied as a nitrogen source along with the feed medium; b. size reduction of ViPs, wherein the ViPs at a concentration of 5-7.5 mg/ml is subjected to high pressure homogenization at 1500 bar at 2-8°C and the same activity repeated for at least 45 passes or by a microwave oven so that to a corresponding molecular size of purified ViPs of approximately 250 kDa is obtained; c. treating the purified ViPs of step (b) at a concentration of 5 mg/ml to 7.5 mg/ml of purified ViPs of ~ 250 kDa in the presence of a cross linking agent EDAC to form the Vi-polysaccharide-carrier protein conjugate; d. diafiltering through continuous buffer exchange with phosphate buffered saline of the ViPs-carrier protein conjugate of step (c) with a 1000 kDa membrane to obtain the purified ViPs-carrier protein vaccine antigen; wherein the molecular size of the ViPs-carrier protein conjugate molecule ranges between 0.25 kDa to 0.35 kDa. a. Fed-batch mode of cultivation to obtain purified ViPs with a feed medium, the feed medium comprising feeding a solution containing glucose at a range of 1 to 2 mg/mL concentration at a pH maintained in the range of 6.90 to 7.20 and dissolved oxygen level maintained between 40%-60%, wherein ammonia solution (50%) was supplied as a nitrogen source along with the feed medium; b. size reduction of ViPs, wherein the ViPs at a concentration of 5-7.5 mg/ml is subjected to high pressure homogenization at 1500 bar at 2-8°C and the same activity repeated for at least 45 passes or by a microwave oven so that to a corresponding molecular size of purified ViPs of approximately 250 kDa is obtained; c. treating the purified ViPs of step (b) at a concentration of 5 mg/ml to 7.5 mg/ml of purified ViPs of ~ 250 kDa in the presence of a cross linking agent EDAC to form the Vi-polysaccharide-carrier protein conjugate; d. diafiltering through continuous buffer exchange with phosphate buffered saline of the ViPs-carrier protein conjugate of step (c) with a 1000 kDa membrane to obtain the purified ViPs-carrier protein vaccine antigen;
A method for performing a cell load balancing by a base station in a wireless communication system configured to transmit a plurality of transport blocks, TBs, using a plurality of physical resource blocks, PRBs, the method comprising: identifying a usage of the PRBs used for the transmission of the TBs; and transmitting the identified usage of the PRBs for the cell load balancing to another base station; wherein the identifying of the usage of the PRBs comprises: identifying the TBs to be transmitted (TBO, TB1, TB2), identifying the PRBs (PRBO, PRB1, PRB2, PRB3) used to transmit each TB, identifying the number of times each PRB is used in the transmission of the TBs, inverting the number of times each PRB is used in the transmission of the TBs, summing, for each TB, the inverted numbers corresponding to the PRBs used in the transmission of the respective TB, and calculating the usage of the PRBs based on adding together the sum for each TB. identifying a usage of the PRBs used for the transmission of the TBs; and transmitting the identified usage of the PRBs for the cell load balancing to another base station; wherein the identifying of the usage of the PRBs comprises: identifying the TBs to be transmitted (TBO, TB1, TB2), identifying the PRBs (PRBO, PRB1, PRB2, PRB3) used to transmit each TB, identifying the number of times each PRB is used in the transmission of the TBs, inverting the number of times each PRB is used in the transmission of the TBs, summing, for each TB, the inverted numbers corresponding to the PRBs used in the transmission of the respective TB, and calculating the usage of the PRBs based on adding together the sum for each TB. identifying the TBs to be transmitted (TBO, TB1, TB2), identifying the PRBs (PRBO, PRB1, PRB2, PRB3) used to transmit each TB, identifying the number of times each PRB is used in the transmission of the TBs, inverting the number of times each PRB is used in the transmission of the TBs, summing, for each TB, the inverted numbers corresponding to the PRBs used in the transmission of the respective TB, and calculating the usage of the PRBs based on adding together the sum for each TB.
N -ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide, or a pharmaceutically acceptable salt thereof.
A fluid management layer comprising an integrated, carded, nonwoven having a basis weight of between about 115 grams per square meter (gsm) and about 250 gsm, the fluid management layer comprising a plurality of absorbent fibers, a plurality of stiffening fibers and a plurality of resilient fibers, wherein the absorbent fibers comprise from about 20 percent to about 60 percent by weight as determined by the Material Composition Analysis Method disclosed herein, wherein the stiffening fibers have a dtex of between 4 and 10, the resilient fibers having a dtex of between 3 and 12, as measured by the Fiber Decitex method disclosed herein; wherein a first carded nonwoven , an optional second carded nonwoven , and a third carded nonwoven are integrated, each forming a stratum in the overall fluid management layer ; wherein the first carded nonwoven comprises from about 5 percent to about 35 percent by weight of absorbent fibers, wherein the third stratum comprises from about 40 percent to about 100 percent by weight of absorbent fibers. wherein a first carded nonwoven , an optional second carded nonwoven , and a third carded nonwoven are integrated, each forming a stratum in the overall fluid management layer ; wherein the first carded nonwoven comprises from about 5 percent to about 35 percent by weight of absorbent fibers, wherein the third stratum comprises from about 40 percent to about 100 percent by weight of absorbent fibers.
The use of a propylene 1-hexene copolymer for producing an injection molded container to be used in a microwave oven wherein the propylene 1-hexene copolymer has the following features: - a 1-hexene content, measured by 13 C NMR, of between 0.5 and 3.1 % by weight; - a molecular weight distribution, MWD, measured by GPC, expressed in terms of Mw/Mn, of greater than 4.0; - a melt flow rate, MFR; 230°C, 2.16 kg, ISO 1133-1 2011 , of between 5 to 75 g/10 min; and - a fraction soluble in xylene at 25°C, ISO 16152:2005, of lower than 2.5 wt%. - a 1-hexene content, measured by 13 C NMR, of between 0.5 and 3.1 % by weight; - a molecular weight distribution, MWD, measured by GPC, expressed in terms of Mw/Mn, of greater than 4.0; - a melt flow rate, MFR; 230°C, 2.16 kg, ISO 1133-1 2011 , of between 5 to 75 g/10 min; and - a fraction soluble in xylene at 25°C, ISO 16152:2005, of lower than 2.5 wt%.
A method for extending a cover time of protection on a licensed software by suppressing a transmission of information about a cracking attack on the licensed software, wherein the cracking attack is an attack whose characteristics and purpose are to remove, disable, or otherwise evade license protection for the software and thereby render the software usable in violation of one or more license terms, the licensed software being executed by a computer, - the method comprising: - a) detecting , by the computer, the cracking attack on the licensed software; being characterized in that ,upon detection, the method further comprises the following steps: • b) simulating , by the computer, a cracked program behavior of the licensed software by using the licensed software; • c) incrementing, by the computer, a counter each time the licensed software is loaded and executed; • d) comparing, by the computer, the counter to a predetermined threshold of uses of the licensed software; • e) activating , by the computer, only when the counter matches the threshold of uses of the licensed software, at least one latent protective measure; and f) repeating, by the computer, while the counter does not match the threshold of uses of the licensed software, the simulating, incrementing and comparing steps. - the method comprising: - a) detecting , by the computer, the cracking attack on the licensed software; being characterized in that ,upon detection, the method further comprises the following steps: • b) simulating , by the computer, a cracked program behavior of the licensed software by using the licensed software; • c) incrementing, by the computer, a counter each time the licensed software is loaded and executed; • d) comparing, by the computer, the counter to a predetermined threshold of uses of the licensed software; • e) activating , by the computer, only when the counter matches the threshold of uses of the licensed software, at least one latent protective measure; and f) repeating, by the computer, while the counter does not match the threshold of uses of the licensed software, the simulating, incrementing and comparing steps. - a) detecting , by the computer, the cracking attack on the licensed software; being characterized in that ,upon detection, the method further comprises the following steps: • b) simulating , by the computer, a cracked program behavior of the licensed software by using the licensed software; • c) incrementing, by the computer, a counter each time the licensed software is loaded and executed; • d) comparing, by the computer, the counter to a predetermined threshold of uses of the licensed software; • e) activating , by the computer, only when the counter matches the threshold of uses of the licensed software, at least one latent protective measure; and f) repeating, by the computer, while the counter does not match the threshold of uses of the licensed software, the simulating, incrementing and comparing steps.
Method for conditioning an acid waste by cementation, the acid waste being selected from among liquids having a pH of no more than 4, semi-liquids having a pH of no more than 4, solids of which the partial or full dissolution in water leads to a solution or suspension having a pH of no more than 4, and mixtures thereof, which comprises the steps of: a) preparing a cement paste having as components at least: a magnesium phosphate cement and the acid waste, and b) hardening the cement paste thus obtained, and which is characterized in that at step a), the cement paste is prepared without subjecting beforehand the acid waste to any treatment consisting in reducing the acidity thereof. a) preparing a cement paste having as components at least: a magnesium phosphate cement and the acid waste, and b) hardening the cement paste thus obtained,
A process for reducing a chloride content of a hydrocarbon feed stream, comprising: cracking a chloride containing thermoplastic material for obtaining a chloride containing pyrolysis oil; contacting a hydrocarbon feed stream comprising a chloride containing pyrolysis oil with a catalyst on a catalyst support, the catalyst being Cu and Zn on an alumina support, in the presence of hydrogen gas at a temperature of 60-300°C and a pressure of 25-35 bars to reduce one or more organic chloride compounds present in the hydrocarbon feed stream and form a hydrocarbon product stream and HCl; removing the HCl from the hydrocarbon product stream; wherein the chloride containing pyrolysis oil has a boiling point of less than 400°C; wherein the hydrocarbon feed stream has a chloride content of greater than 2000 ppmw and less than 5000 ppmw relative to the total weight of the hydrocarbon feed stream; and wherein the molar ratio of the hydrogen gas to the hydrocarbon feed stream is 10:1 to 1:1.5, whereby the hydrocarbon product stream has a chloride content of less than 10 ppmw relative to the total weight of the hydrocarbon product stream. cracking a chloride containing thermoplastic material for obtaining a chloride containing pyrolysis oil; contacting a hydrocarbon feed stream comprising a chloride containing pyrolysis oil with a catalyst on a catalyst support, the catalyst being Cu and Zn on an alumina support, in the presence of hydrogen gas at a temperature of 60-300°C and a pressure of 25-35 bars to reduce one or more organic chloride compounds present in the hydrocarbon feed stream and form a hydrocarbon product stream and HCl; removing the HCl from the hydrocarbon product stream; wherein the chloride containing pyrolysis oil has a boiling point of less than 400°C; wherein the hydrocarbon feed stream has a chloride content of greater than 2000 ppmw and less than 5000 ppmw relative to the total weight of the hydrocarbon feed stream; and wherein the molar ratio of the hydrogen gas to the hydrocarbon feed stream is 10:1 to 1:1.5, whereby the hydrocarbon product stream has a chloride content of less than 10 ppmw relative to the total weight of the hydrocarbon product stream.
An assembled camera module comprising: a lens barrel having at least one lens; a holder coupled to the lens barrel ; a board disposed at a lower portion of the holder so as to face the lens; an adhesive element configured to couple the holder and the board to each other; an opening connected to a first space (S1) which is defined via coupling of the board and the holder ; and an image sensor disposed on the board, wherein the opening is provided as a via-hole formed in the board through its upper side and its lower side, and wherein the via-hole is disposed between the image sensor and the adhesive element , characterized in that a housing is coupled to the holder and accommodates the board, and that the opening is a path through which an air in the first space (S1) is discharged, which communicates with a second space (S2) formed inside the housing . a lens barrel having at least one lens; a holder coupled to the lens barrel ; a board disposed at a lower portion of the holder so as to face the lens; an adhesive element configured to couple the holder and the board to each other; an opening connected to a first space (S1) which is defined via coupling of the board and the holder ; and an image sensor disposed on the board, wherein the opening is provided as a via-hole formed in the board through its upper side and its lower side, and wherein the via-hole is disposed between the image sensor and the adhesive element , characterized in that a housing is coupled to the holder and accommodates the board, and that the opening is a path through which an air in the first space (S1) is discharged, which communicates with a second space (S2) formed inside the housing .
A bispecific activatable antibody, wherein said bispecific activatable antibody comprises: (i) a first arm comprising an antigen-binding fragment of an immune effector cell engaging antibody that includes a first antibody or antigen-binding fragment thereof (AB1) that binds a first immune effector cell target; (ii) a second arm comprising an antigen-binding fragment of a target binding antibody that includes a second antibody or antigen-binding fragment thereof (AB2) that binds a second target; wherein the AB1 is attached to a first masking moiety (MM1) such that coupling of the MM1 to the AB1 reduces the ability of the AB1 to bind the first target, wherein the MM1 is coupled to the AB1 via a first cleavable moiety (CM1) sequence that includes a substrate for a protease; wherein the AB2 is attached to a second masking moiety (MM2) such that coupling of the MM2 to the AB2 reduces the ability of the AB2 to bind the second target; wherein the MM2 is coupled to the AB2 via a second cleavable moiety (CM2) sequence that includes a substrate for a protease; and wherein the first arm of the bispecific activatable antibody in an uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: MM1-CM1-AB1 and the second arm of the bispecific activatable antibody in the uncleaved state has a structural arrangement from N-terminus to C-terminus as follows: MM2-CM2-AB2. (i) a first arm comprising an antigen-binding fragment of an immune effector cell engaging antibody that includes a first antibody or antigen-binding fragment thereof (AB1) that binds a first immune effector cell target; (ii) a second arm comprising an antigen-binding fragment of a target binding antibody that includes a second antibody or antigen-binding fragment thereof (AB2) that binds a second target; wherein the AB1 is attached to a first masking moiety (MM1) such that coupling of the MM1 to the AB1 reduces the ability of the AB1 to bind the first target, wherein the MM1 is coupled to the AB1 via a first cleavable moiety (CM1) sequence that includes a substrate for a protease; wherein the AB2 is attached to a second masking moiety (MM2) such that coupling of the MM2 to the AB2 reduces the ability of the AB2 to bind the second target; wherein the MM2 is coupled to the AB2 via a second cleavable moiety (CM2) sequence that includes a substrate for a protease; and wherein the first arm of the bispecific activatable antibody in an uncleaved state has the structural arrangement from N-terminus to C-terminus as follows: MM1-CM1-AB1 and the second arm of the bispecific activatable antibody in the uncleaved state has a structural arrangement from N-terminus to C-terminus as follows: MM2-CM2-AB2.
An apparatus for packaging semiconductor devices, comprising: a first board including a first substrate (112; 212) having a front side (114; 213) and a backside (115; 215), arrays of die contacts (116; 296) located at the front side of the first substrate, arrays of first backside terminals (117; 291) electrically coupled to the die contacts, arrays of second backside terminals (118; 292), and a plurality of individual package areas that have a die attach site, an array of the first backside terminals, and an array of the second backside terminals, wherein the first board further comprises first interconnects (119; 220) electrically coupling the die contacts with corresponding first backside terminals; a second board having a first side laminated to the front side of the first substrate, a second side , openings through the second board aligned with individual package areas that define die cavities , and arrays of front contacts at the second side electrically coupled to the second backside terminals by second interconnects (140; 274) extending through the first board and the second board; a semiconductor die attached to the front side of the first substrate, wherein an array of the die contacts are positioned at the die attach site so as not to be covered by the semiconductor die; and wherein the second interconnects extending through the first board and the second board provide a package stack route that can transmit power and electrical signals to/from another packaged semiconductor component when such another packaged semiconductor component is stacked on top of the second board. a first board including a first substrate (112; 212) having a front side (114; 213) and a backside (115; 215), arrays of die contacts (116; 296) located at the front side of the first substrate, arrays of first backside terminals (117; 291) electrically coupled to the die contacts, arrays of second backside terminals (118; 292), and a plurality of individual package areas that have a die attach site, an array of the first backside terminals, and an array of the second backside terminals, wherein the first board further comprises first interconnects (119; 220) electrically coupling the die contacts with corresponding first backside terminals; a second board having a first side laminated to the front side of the first substrate, a second side , openings through the second board aligned with individual package areas that define die cavities , and arrays of front contacts at the second side electrically coupled to the second backside terminals by second interconnects (140; 274) extending through the first board and the second board; a semiconductor die attached to the front side of the first substrate, wherein an array of the die contacts are positioned at the die attach site so as not to be covered by the semiconductor die; and wherein the second interconnects extending through the first board and the second board provide a package stack route that can transmit power and electrical signals to/from another packaged semiconductor component when such another packaged semiconductor component is stacked on top of the second board.
A computer implemented method for structuring data to enable column-oriented access to data in a distributed and fault tolerant manner, comprising: providing a data store configured to store column-oriented data into which data is inserted, and from which data is retrieved, randomly or sequentially, at high rates by: decomposing a table progressively into tablets and partitions by: recursively dividing said table's key space; wherein said table contains tablets , each of which is assigned a particular range of possible keys; wherein each tablet contains partitions for key sub-ranges; wherein each partition or portion of a partition has a single actively updated bucket ; wherein each partition includes a plurality of segments; and wherein once a bucket has reached a limited size, a new bucket is allocated and the previous data storage container is spilled to segments; distributing operations on tablets to different nodes; using different threads to handle operations on individual partitions or portions of partitions ; and decomposing large-scale restructuring operations on tablets into operations on individual partitions or portions of partitions ; wherein tablets can be restructured using redirection links; and wherein redirection links are pointers between tablets to allow accesses and updates to proceed among tablets during restructuring. recursively dividing said table's key space; wherein said table contains tablets , each of which is assigned a particular range of possible keys; wherein each tablet contains partitions for key sub-ranges; wherein each partition or portion of a partition has a single actively updated bucket ; wherein each partition includes a plurality of segments; and wherein once a bucket has reached a limited size, a new bucket is allocated and the previous data storage container is spilled to segments; distributing operations on tablets to different nodes; using different threads to handle operations on individual partitions or portions of partitions ; and decomposing large-scale restructuring operations on tablets into operations on individual partitions or portions of partitions ; wherein tablets can be restructured using redirection links; and wherein redirection links are pointers between tablets to allow accesses and updates to proceed among tablets during restructuring.
A topical composition comprising: (i) an antimicrobial active which is at least one of caprylhydroxamic acid or piroctone olamine; and (ii) an atractylenolide compound; wherein weight ratio of the amount of said atractylenolide compound to that of said antimicrobial active is at least 5:1; wherein said atractylenolide compound is atractylenolide I or II. (i) an antimicrobial active which is at least one of caprylhydroxamic acid or piroctone olamine; and (ii) an atractylenolide compound; wherein weight ratio of the amount of said atractylenolide compound to that of said antimicrobial active is at least 5:1; wherein said atractylenolide compound is atractylenolide I or II.