mhurhangee/patent-ind-claim-en huggingface dataset:
A method for preparing a nucleic acid library from a low quality nucleic acid sample comprising: (a) providing a plurality of nucleic acids obtained from the low quality nucleic acid sample; and (b) selectively shearing the plurality of nucleic acids comprising: (i) obtaining a first fraction comprising longer nucleic acids of the plurality of nucleic acids, and a second fraction comprising shorter nucleic acids of the plurality of nucleic acids, (ii) shearing the nucleic acids of the first fraction, and (iii) combining the sheared first fraction and the second fraction, thereby preparing the nucleic acid library. (a) providing a plurality of nucleic acids obtained from the low quality nucleic acid sample; and (b) selectively shearing the plurality of nucleic acids comprising: (i) obtaining a first fraction comprising longer nucleic acids of the plurality of nucleic acids, and a second fraction comprising shorter nucleic acids of the plurality of nucleic acids, (ii) shearing the nucleic acids of the first fraction, and (iii) combining the sheared first fraction and the second fraction, thereby preparing the nucleic acid library. (i) obtaining a first fraction comprising longer nucleic acids of the plurality of nucleic acids, and a second fraction comprising shorter nucleic acids of the plurality of nucleic acids, (ii) shearing the nucleic acids of the first fraction, and (iii) combining the sheared first fraction and the second fraction, thereby preparing the nucleic acid library.
A therapeutic combination of at least one fatty acid-bile acid conjugate (FABAC) or a pharmaceutically acceptable salt thereof, and at least one thyroid hormone receptor agonist or thyroid hormone mimetic or a pharmaceutically acceptable salt thereof, and a carrier, wherein said at least one fatty acid-bile acid conjugate comprises 3-beta-arachidylamido-7-alpha,1-2alpha-dihydroxy-5-beta-cholan-24-oic acid (Aramchol TM ) and wherein said at least one thyroid hormone receptor agonist or thyroid hormone mimetic comprises 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1 ,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo- 2,3,4,5-tetrahydro triazine-6-carbonitrile (MGL-3196).
A modular storage system , comprising a plurality of box-shaped structural units (2-14), one or more of which are storage units used for storage, and each structural unit (2-14) having front and back faces and left, right, top and bottom sides, wherein: the box-shaped structural units (2-14) are laterally attachable to each other side-by-side through corresponding attachment points on the left and right sides, thereby to construct a joined structure of at least two of the box-shaped structural units; one or more of the box-shaped structural units (2-14) are reversible structural units (2-14), in which the corresponding attachment points are positioned and shaped so that the reversible structural unit is attachable in the lateral side-by-side attachment so that the corresponding front faces of adjacent joined structural units are oriented either in one direction or in opposite directions; and one or more of the reversible structural units (2-14) comprise spacing elements on the left and right sides which result in a vertical gap in the joined structure between adjacent left or right sides of the joined structural units, the spacing elements being provided at least in part by raised vertical front and back edges on the left and right sides that serve to provide the vertical gap between the raised vertical front and back edges and also hide the vertical gap from a front or rear perspective of the joined structure ; C HARACTERISED IN THAT the modular storage system is used to create a joined structure from the box-shaped structural units (2-14) with electrical cabling, communications cabling or other services passed through gaps between the box-shaped structural units (2-14); the one or more reversible structural units which comprise the spacing elements on the left and right sides (2-14) are service accessible structural units where the spacing elements provide part of a service access path between the box-shaped structural units through which the electrical cabling, communications cabling or other services are passed in use to service the service accessible structural units; and the box-shaped structural units are stackable vertically and have heights, some of which differ, that are integer multiples of a fundamental height; and the box-shaped structural units are attachable through one or more fasteners suitably sized and shaped to engage and hold together the corresponding attachment points on the left or right sides of adjacent structural units, the corresponding attachment points and fasteners being spaced vertically and symmetrically with respect to the fundamental height thereby to allow free stacking of the box-shaped structural units having different heights and still allowing full side-by-side attachment through all the attachment points of all the box-shaped structural units.
Method for producing a tubular filter membrane element for microfiltration, wherein a membrane tube portion composed of plastic is closed at its one axial end and is provided at the opposite axial end with an adapter part composed of plastic, wherein the membrane tube portion is composed of a permeable plastics material, wherein the permeability is formed either by a fundamental porosity of the material and/or by a subsequently introduced perforation, wherein the membrane tube portion is arranged in a cavity of an injection-moulding device on a positioning mandrel and is held by said mandrel during the injection-moulding process, characterized in that the adapter part is injection-moulded onto the membrane tube portion , wherein the adapter part is configured in the form of a connection socket for a fluid line, wherein the adapter part is welded to the membrane tube portion , wherein the membrane tube portion is closed at its one axial end by virtue of this end of said portion being brought into abutment with a hot die and being shaped into a desired shape, wherein a form which tapers conically in an axial direction is formed at the closed end of the membrane tube portion , wherein the membrane tube portion is positioned on a mandrel during the closing of its one axial end, and wherein the membrane tube portion is rotated about its longitudinal axis during the closing of the axial end, and/or in that the hot die is rotated during the closing of the axial end of the membrane tube portion . wherein the membrane tube portion is composed of a permeable plastics material, wherein the permeability is formed either by a fundamental porosity of the material and/or by a subsequently introduced perforation, wherein the membrane tube portion is arranged in a cavity of an injection-moulding device on a positioning mandrel and is held by said mandrel during the injection-moulding process, the adapter part is injection-moulded onto the membrane tube portion , wherein the adapter part is configured in the form of a connection socket for a fluid line, wherein the adapter part is welded to the membrane tube portion , wherein the membrane tube portion is closed at its one axial end by virtue of this end of said portion being brought into abutment with a hot die and being shaped into a desired shape, wherein a form which tapers conically in an axial direction is formed at the closed end of the membrane tube portion , wherein the membrane tube portion is positioned on a mandrel during the closing of its one axial end, and wherein the membrane tube portion is rotated about its longitudinal axis during the closing of the axial end,
A base station comprising: a transmitting section configured to transmit downlink control information that is used for scheduling of a downlink shared channel; and a control section configured to control a generation of downlink control information, wherein the downlink control information allows determining an assignment symbol location of the downlink shared channel and a reception timing of a delivery acknowledgement signal for the downlink shared channel. a transmitting section configured to transmit downlink control information that is used for scheduling of a downlink shared channel; and a control section configured to control a generation of downlink control information, wherein the downlink control information allows determining an assignment symbol location of the downlink shared channel and a reception timing of a delivery acknowledgement signal for the downlink shared channel.
A multilayer film comprising: Layer A which is a sealant layer having a top facial surface and a bottom facial surface and comprising: (a) a copolymer comprising ethylene and alkylacrylate, wherein the copolymer has a melt index (I 2 ) of 2 to 30 g/10 minutes and wherein the total amount of alkylacrylate in the copolymer is 5 to 30 weight percent based on the weight of the copolymer, wherein Layer A comprises 40 to 90 weight percent of the copolymer based on the weight of Layer A; and (b) a polyolefin elastomer having a crystallinity of 30% or less and a melt index (I 2 ) of 1.0 g/10 minutes or more, wherein Layer A comprises 10 to 60 weight percent of the polyolefin elastomer based on the weight of Layer A; and Layer B having a top facial surface and a bottom facial surface; wherein the top facial surface of Layer B is in adhering contact with a bottom facial surface of Layer A. Layer A which is a sealant layer having a top facial surface and a bottom facial surface and comprising: (a) a copolymer comprising ethylene and alkylacrylate, wherein the copolymer has a melt index (I 2 ) of 2 to 30 g/10 minutes and wherein the total amount of alkylacrylate in the copolymer is 5 to 30 weight percent based on the weight of the copolymer, wherein Layer A comprises 40 to 90 weight percent of the copolymer based on the weight of Layer A; and (b) a polyolefin elastomer having a crystallinity of 30% or less and a melt index (I 2 ) of 1.0 g/10 minutes or more, wherein Layer A comprises 10 to 60 weight percent of the polyolefin elastomer based on the weight of Layer A; and (a) a copolymer comprising ethylene and alkylacrylate, wherein the copolymer has a melt index (I 2 ) of 2 to 30 g/10 minutes and wherein the total amount of alkylacrylate in the copolymer is 5 to 30 weight percent based on the weight of the copolymer, wherein Layer A comprises 40 to 90 weight percent of the copolymer based on the weight of Layer A; and (b) a polyolefin elastomer having a crystallinity of 30% or less and a melt index (I 2 ) of 1.0 g/10 minutes or more, wherein Layer A comprises 10 to 60 weight percent of the polyolefin elastomer based on the weight of Layer A; and Layer B having a top facial surface and a bottom facial surface;
A method of obtaining a cell population enriched for tumor-reactive T-cells, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample; (b) specifically selecting CD8 + T cells that are 4-1BB+ (CD137)/PD-1+ (CD279) from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells. (a) obtaining a bulk population of T cells from a tumor sample; (b) specifically selecting CD8 + T cells that are 4-1BB+ (CD137)/PD-1+ (CD279) from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells.
Releasable plug connection having a tubular plug-in part and having a sleeve-shaped receiving part which has an insertion opening through which the plug-in part is able to be introduced into a sleeve interior space of the receiving part , wherein, on the inner circumference of the receiving part , at least one annular groove is provided, in which annular groove there is arranged an annular seal which provides sealing in the annular gap between the inner circumference of the receiving part and the outer circumference of the plug-in part , wherein the insertion opening of the receiving part opens out into a first interior-space section of the sleeve interior space, which first interior-space section , in relation to an adjacent interior-space section , is in the form of a cross-sectional extension and is delimited by an annular shoulder , and wherein, in the first interior-space section of the sleeve interior space, it is possible for there to be inserted an insertion sleeve whose face circumferential edge facing towards the annular shoulder is spaced apart from the annular shoulder in such a way that the annular groove is formed between the face circumferential edge of the insertion sleeve and the annular shoulder , and wherein the insertion sleeve is able to be inserted into the first interior-space section until an annular shoulder or annular flange provided on the sleeve outer circumference of the insertion sleeve bears against a face edge of the receiving part that borders the insertion opening , wherein the plug-in part bears at least one holding projection on its outer circumference, wherein a connecting element is connected to the receiving part , characterized in that at least one inwardly directed edge is held on the connecting element such that it is able to be bent or pivoted up and engages behind the holding projection after the plug-in part has been pushed in, wherein there is provided a sleeve-shaped securing element which engages around the connecting element in a displaceable manner in such a way that the securing element is displaceable between a release position, in which release position the axial pushing movement of the securing element is convertible into an opening movement, oriented transversely thereto, of the holding edge , and a securing position, in which securing position the securing element engages around the connecting element in such a way that bending-up of the connecting element in the region of the holding edges is prevented, and wherein, in an intermediate or coupling position of the securing element , the connecting element projects at least regionally over the securing element in such a way that the holding edges are able to be bent up when the holding projection provided on the plug-in part is pushed in.
Method for producing a moulding element intended to be assembled in a mould for moulding a tyre, said moulding element comprising a moulding surface designed for moulding part of the tyre, and an external surface opposite to the moulding surface, venting means suited to discharging a flow of air from the moulding surface towards the external surface , said venting means comprising a first part of width L1 comprised between 0.03 mm and 0.07 mm and of depth P1 less than or equal to 3 mm, said first part opening onto the moulding surface , and a second part in communication with the first part and opening onto the external surface , the width L2 of the second part being comprised between 1 mm and 5 mm and more preferably between 2 mm and 3 mm, the first part forming a path that is closed on itself, said method comprising the following steps: i) a step of creating the first part in the moulding element using a laser, said first part having a longitudinal axis A1; ii) a step of creating the second part in the moulding element, said second part being in communication with said first part , said second part having a longitudinal axis A2; in said method: iii) the step of creating the second part is performed before the step of creating the first part ; iv) steps i and ii being performed in such a way that the axis A2 of the second part and the axis A1 of the first part are spaced apart by an offset D of at least 0.5 mm. i) a step of creating the first part in the moulding element using a laser, said first part having a longitudinal axis A1; ii) a step of creating the second part in the moulding element, said second part being in communication with said first part , said second part having a longitudinal axis A2; in said method: iii) the step of creating the second part is performed before the step of creating the first part ; iv) steps i and ii being performed in such a way that the axis A2 of the second part and the axis A1 of the first part are spaced apart by an offset D of at least 0.5 mm.
Medical capsule including an electrical circuit and an internal power source for selectively supplying the electrical circuit with electrical energy, a switching element ; a switch driver connected to the electrical circuit ; at least one photosensitive element configured to output a driver control signal to the switch driver to initiate the supply of electrical energy to the electrical circuit , characterised by: a feedback control signal configured to be output by the electrical circuit to the switch driver , wherein the switch driver is configured to maintain the supply of electrical energy to the electrical circuit when the feedback control signal is present, even if the photosensitive element is not exposed to light and does not output the driver control signal. a switching element ; a switch driver connected to the electrical circuit ; at least one photosensitive element configured to output a driver control signal to the switch driver to initiate the supply of electrical energy to the electrical circuit , characterised by: a feedback control signal configured to be output by the electrical circuit to the switch driver , wherein the switch driver is configured to maintain the supply of electrical energy to the electrical circuit when the feedback control signal is present, even if the photosensitive element is not exposed to light and does not output the driver control signal.
Rubber compound for the preparation of a tread portion of a pneumatic tyre; said rubber compound comprising at least one cross-linkable unsaturated chain polymer base capable of assuming all of the chemical-physical and mechanical characteristics of an elastomer after cross-linking, a filler comprising silica, a plasticizing agent and a curing system; said rubber compound being characterized in that said cross-linkable unsaturated chain polymer base has a peak Tan δ value between -15°C and 5°C and in that said plasticizing agent consists of an aliphatic chain comprising at least one polar group and has a melting temperature of between 5°C and 40°C.
A lighting system comprising: a grid input configured for connection to an external grid power supply ; an LED luminaire system comprising a set of multiple luminaires (L1-L32), each luminaire comprising an LED lighting unit (30a-30d) and a driver (24; 24a-24d) connected to the grid input configured to inject current into the LED lighting unit from the external grid power supply ; and a solar input configured for connection to a solar panel ; a solar converter connected to the solar input configured to convert the output from the solar panel into a first power; a connection unit configured to connect the LED lighting units of the set of the multiple luminaires together and to the solar converter and thereby the LED lighting units of the set of multiple luminaires are adapted to share the first power, characterized in that the respective driver of each luminaire and the solar converter are in parallel connection with the respective LED lighting unit of the luminaire, and the solar converter and the respective driver of each luminaire are adapted to drive the respective LED lighting unit of the luminaire simultaneously. a grid input configured for connection to an external grid power supply ; an LED luminaire system comprising a set of multiple luminaires (L1-L32), each luminaire comprising an LED lighting unit (30a-30d) and a driver (24; 24a-24d) connected to the grid input configured to inject current into the LED lighting unit from the external grid power supply ; and a solar input configured for connection to a solar panel ; a solar converter connected to the solar input configured to convert the output from the solar panel into a first power; a connection unit configured to connect the LED lighting units of the set of the multiple luminaires together and to the solar converter and thereby the LED lighting units of the set of multiple luminaires are adapted to share the first power, characterized in that the respective driver of each luminaire and the solar converter are in parallel connection with the respective LED lighting unit of the luminaire, and the solar converter and the respective driver of each luminaire are adapted to drive the respective LED lighting unit of the luminaire simultaneously.
An ink fountain device for forming an ink fountain when facing an ink fountain roller of a printing press, comprising: a base ; a plate ; an advancing and retracting mechanism for advancing and retracting the plate along an advancing and retracting direction towards and from the roller ; being characterized in that a thin sheet is arranged on the base , wherein the thin sheet has plural holes rotatably accommodating balls , and is thinner in thickness than a diameter of said balls , and wherein said plate is arranged over the thin sheet and supported by said balls . a base ; a plate ; an advancing and retracting mechanism for advancing and retracting the plate along an advancing and retracting direction towards and from the roller ; being characterized in that a thin sheet is arranged on the base , wherein the thin sheet has plural holes rotatably accommodating balls , and is thinner in thickness than a diameter of said balls , and wherein said plate is arranged over the thin sheet and supported by said balls .
An abrasive article comprising: a nonwoven substrate material having a top surface and a bottom surface; a thermoplastic fastener ; and a plurality of abrasive particles, characterized in that the abrasive article further comprises a woven cloth , wherein the cloth is adhered to the top surface of the nonwoven substrate material , wherein the thermoplastic fastener is disposed on the cloth , wherein the plurality of abrasive particles are disposed on at least the bottom surface of the nonwoven substrate material , wherein the thermoplastic fastener is friction welded to the cloth , and wherein the cloth has an open area of less than 5%. a nonwoven substrate material having a top surface and a bottom surface; a thermoplastic fastener ; and a plurality of abrasive particles, characterized in that the abrasive article further comprises a woven cloth , wherein the cloth is adhered to the top surface of the nonwoven substrate material , wherein the thermoplastic fastener is disposed on the cloth , wherein the plurality of abrasive particles are disposed on at least the bottom surface of the nonwoven substrate material , wherein the thermoplastic fastener is friction welded to the cloth , and wherein the cloth has an open area of less than 5%.