mhurhangee/patent-ind-claim-en huggingface dataset:
An integrated optical device, comprising: a) a waveguide substrate layer comprising a plurality of channel waveguides and one or more biosensing regions with a plurality of nanometer-scale apertures comprising analyte regions, wherein the waveguides are configured to deliver optical energy from an optical energy source to the analyte regions, wherein each analyte region is disposed sufficiently proximal to a core of a waveguide of the plurality of waveguides to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide ; b) a sensor array layer ; and c) a a microlens array layer adapted to collect optical energy signals from the biosensing region(s) and direct the optical energy signals so collected to the sensor array layer ; wherein the sensor array layer is positioned under the microlens array layer , the microlens array layer is positioned under the waveguide substrate layer and each microlens of the microlens array layer is adapted to collect photons emitted from a single biosensing region. a) a waveguide substrate layer comprising a plurality of channel waveguides and one or more biosensing regions with a plurality of nanometer-scale apertures comprising analyte regions, wherein the waveguides are configured to deliver optical energy from an optical energy source to the analyte regions, wherein each analyte region is disposed sufficiently proximal to a core of a waveguide of the plurality of waveguides to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide ; b) a sensor array layer ; and c) a a microlens array layer adapted to collect optical energy signals from the biosensing region(s) and direct the optical energy signals so collected to the sensor array layer ;
A flow body comprising: - a curved suction skin having a first perforation, a leading edge and two skin sections extending therefrom, wherein each skin section has an outer end facing away from the leading edge , - an interior suction duct having a second perforation and extending through an inside of the curved suction skin in a distance from the leading edge , - two sidewall members , connected to the outer ends of the skin sections, wherein the sidewall members are made of a composite material, and - at least one inner spar delimiting the interior suction duct , wherein the curved suction skin comprises a profiled contour shape, which determines a pressure distribution over at least one of the two skin sections when air flows over the curved suction skin , wherein the pressure distribution comprises a stagnation point, a suction peak and a local pressure maximum downstream of the suction peak and upstream a trailing edge of the flow body, and wherein the first perforation extends from the stagnation point to the local pressure maximum. - a curved suction skin having a first perforation, a leading edge and two skin sections extending therefrom, wherein each skin section has an outer end facing away from the leading edge , - an interior suction duct having a second perforation and extending through an inside of the curved suction skin in a distance from the leading edge , - two sidewall members , connected to the outer ends of the skin sections, wherein the sidewall members are made of a composite material, and - at least one inner spar delimiting the interior suction duct ,
An isolated FcRn-antagonist which consists of a variant IgG1 Fc region, or FcRn-binding fragment thereof, wherein the Fc domains of the Fc region or FcRn-binding fragment thereof comprise the amino acids Y, T, E, K, F, and Y at EU positions 252, 254, 256, 433, 434, and 436 respectively, and wherein the Fc region binds to FcRn with increased affinity and reduced pH dependence relative to a wild-type IgG1 Fc region.
A baling apparatus comprising a bale forming chamber (Ch) in which an agricultural bale (B) is formed and subsequently released, a release apparatus to control release of the agricultural bale from the bale forming chamber (Ch) and a wrapping apparatus for introducing a wrapping material into the bale forming chamber (Ch) in order that the agricultural bale (B) once formed is wrapped on at least one surface by the wrapping material , characterised in that the baling apparatus further comprises a support extending across the baling apparatus and adjacent the bale forming chamber (Ch), the support incorporating a plurality of moisture sensors (34',34",36',36") arranged upon the support , wherein the sensors (34',34",36',36") are adapted to measure a moisture level of the at least one surface of the agricultural bale.
A method of inserting a first device into a community of at least one device having knowledge of a user's login and password verifier, the method comprising at the first device the steps of: receiving the user's login and password; searching for reachable devices; asking each reachable device if it knows the user's login; receiving at least one response indicating that a reachable device knows the user's login; performing Secure Remote Password (SRP) authentication with each device that knows the user's login , the SRP authentication proving to the device that responded that the first device knows the user's password and proving to the first device that the device that responded knows the user's password verifier; and, in case the SRP authentication is successful: calculating and storing the user's password verifier; and receiving and storing a secret community key. receiving the user's login and password; searching for reachable devices; asking each reachable device if it knows the user's login; receiving at least one response indicating that a reachable device knows the user's login; performing Secure Remote Password (SRP) authentication with each device that knows the user's login , the SRP authentication proving to the device that responded that the first device knows the user's password and proving to the first device that the device that responded knows the user's password verifier; and, in case the SRP authentication is successful: calculating and storing the user's password verifier; and receiving and storing a secret community key. calculating and storing the user's password verifier; and receiving and storing a secret community key.
A method for full duplex communications, implemented by a full duplex wireless communication device for communications using an array of antennas, wherein full duplex communications refer to sending and receiving data by the wireless communication device at the same time and frequency resource elements, characterized by : switching (s340) an operation mode of the full duplex wireless communication device between an antenna sharing mode, in which each of the antennas is used for both transmission and reception at a same frequency band, and an antenna isolation mode, in which said each of the antennas is used for either transmission or reception at the same frequency band; and performing (s350) full duplex wireless communications in the other operation mode than the one of the antenna sharing mode and the antenna isolation mode from which the switching has been made. switching (s340) an operation mode of the full duplex wireless communication device between an antenna sharing mode, in which each of the antennas is used for both transmission and reception at a same frequency band, and an antenna isolation mode, in which said each of the antennas is used for either transmission or reception at the same frequency band; and performing (s350) full duplex wireless communications in the other operation mode than the one of the antenna sharing mode and the antenna isolation mode from which the switching has been made.
A method for quantifying an antimicrobial in a biological sample within 2 hours or less, comprising: a. providing a biological sample obtained from a patient receiving the antimicrobial; b. incubating the biological sample with a reference microbial strain and a fluorophore for detecting cell lesion; c. measuring a first signal of fluorescent intensity in the incubated biological sample using flow cytometry; and d. comparing the first signal to a calibrating curve previously generated for the antimicrobial, thereby quantifying the antimicrobial present in the biological sample; further comprising incubating a separate aliquot of the biological sample with a microbial strain isolated from the patient and the fluorophore, and measuring a second signal of fluorescent intensity in the separate aliquot using flow cytometry; wherein the patient has an infection and is being treated with the antimicrobial; wherein the antimicrobial is an antibiotic or an antifungal; wherein the method is used to determine the effective antimicrobial activity. a. providing a biological sample obtained from a patient receiving the antimicrobial; b. incubating the biological sample with a reference microbial strain and a fluorophore for detecting cell lesion; c. measuring a first signal of fluorescent intensity in the incubated biological sample using flow cytometry; and d. comparing the first signal to a calibrating curve previously generated for the antimicrobial, thereby quantifying the antimicrobial present in the biological sample; further comprising incubating a separate aliquot of the biological sample with a microbial strain isolated from the patient and the fluorophore, and measuring a second signal of fluorescent intensity in the separate aliquot using flow cytometry; wherein the patient has an infection and is being treated with the antimicrobial; wherein the antimicrobial is an antibiotic or an antifungal; wherein the method is used to determine the effective antimicrobial activity. further comprising incubating a separate aliquot of the biological sample with a microbial strain isolated from the patient and the fluorophore, and measuring a second signal of fluorescent intensity in the separate aliquot using flow cytometry; wherein the patient has an infection and is being treated with the antimicrobial; wherein the antimicrobial is an antibiotic or an antifungal; wherein the method is used to determine the effective antimicrobial activity.
A bispecific antibody for use in a method of treating or ameliorating B cell cancer in a subject, comprising administering a dose-escalation protocol that reduces the effect of a cytokine cascade, wherein the dose escalation protocol comprises administering a first dose of the antibody for a first period of time and consecutively administering a second dose of said antibody for a second period of time, wherein said second dose exceeds said first dose, wherein the bispecific antibody comprises a first antigen-binding domain that binds human CD3, a second antigen-binding domain that binds human CD20, and a chimeric Fc domain tethered to each of the first and second antigen-binding domains, wherein the chimeric Fc domain comprises: (a) a human lgG2 lower hinge amino acid sequence comprising PCPAPPVA (SEQ ID NO: 52) from positions 228 to 236 EU numbering; (b) a human lgG1 or a human lgG4 upper hinge amino acid sequence from positions 216 to 227 EU numbering; (c) a human lgG4 CH2 domain amino acid sequence from positions 237 to 340 EU numbering; and (d) a human IgG1 CH1 domain and a human lgG1 CH3 domain, or a human lgG4 CH1 domain and a human lgG4 CH3 domain; wherein the bispecific antibody exhibits a higher binding affinity for human FcγRIIA relative to human FcγRIIB, and exhibits little or no detectable binding affinity to human FcγRI and human FcγRIII, as measured in a surface plasmon resonance assay. (a) a human lgG2 lower hinge amino acid sequence comprising PCPAPPVA (SEQ ID NO: 52) from positions 228 to 236 EU numbering; (b) a human lgG1 or a human lgG4 upper hinge amino acid sequence from positions 216 to 227 EU numbering; (c) a human lgG4 CH2 domain amino acid sequence from positions 237 to 340 EU numbering; and (d) a human IgG1 CH1 domain and a human lgG1 CH3 domain, or a human lgG4 CH1 domain and a human lgG4 CH3 domain;
A flash point determination apparatus , in particular also configured for a combustion point determination, the flash point determination apparatus comprising: a container for receiving a sample to be examined; a lid for closing the container ; and a stirring device for stirring the sample in the container , which can be closed by means of the lid , for a flash point determination test and/or a combustion point determination test, the stirring device comprising: a stirring unit , which can extend at least partially through the lid for stirring the sample located in the container ; a drive unit to be arranged at least partially outside the lid for driving, in particular rotationally driving, the stirring unit ; a coupling unit for coupling the stirring unit to the drive unit ; and an actuating unit , which can be actuated for adjusting the coupling unit in such a way that selectively: in a first actuating position , when the drive unit is pulled up, the lid can be removed from the container together with the stirring unit ; or in a second actuating position , when the drive unit is pulled up, the drive unit can be removed from the container and the stirring unit and the lid remain on the container . a container for receiving a sample to be examined; a lid for closing the container ; and a stirring unit , which can extend at least partially through the lid for stirring the sample located in the container ; a drive unit to be arranged at least partially outside the lid for driving, in particular rotationally driving, the stirring unit ; a coupling unit for coupling the stirring unit to the drive unit ; and an actuating unit , which can be actuated for adjusting the coupling unit in such a way that selectively: in a first actuating position , when the drive unit is pulled up, the lid can be removed from the container together with the stirring unit ; or in a second actuating position , when the drive unit is pulled up, the drive unit can be removed from the container and the stirring unit and the lid remain on the container . in a first actuating position , when the drive unit is pulled up, the lid can be removed from the container together with the stirring unit ; or in a second actuating position , when the drive unit is pulled up, the drive unit can be removed from the container and the stirring unit and the lid remain on the container .
A sports pitch comprising a base layer , an intermediate layer , an impervious layer located between the intermediate layer and the base layer , and a surface layer , wherein the intermediate layer comprises or consists essentially of a foam layer comprising expanded polypropylene and has a thickness of at least 40 mm and up to 65 mm, characterised in that the base layer comprises stones and is up to 200 mm thick and the intermediate layer has a density of at least 30 grams per litre and up to 60 grams per litre.
A system for continuous high-throughput treatment of a population of cells, comprising: a fluidic device comprising a microfluidic channel having an upstream detection zone comprising a detection electrode module configured to detect a change in electrical impedance across the microfluidic channel at the upstream detection zone corresponding to a cell passing the upstream detection zone and a cell treatment zone located downstream of the upstream detection zone and comprising a cell treatment module configured to treat the cell passing the cell treatment zone; a pump fluidically coupled to the fluidic device and configured to pump the population of cells in a carrier liquid unidirectionally along the microfluidic channel; and a processor operatively coupled to the detection electrode module and configured to calculate the velocity V of the cell passing the upstream detection zone based on the change in electrical impedance, and transiently actuate the cell treatment module when the cell reaches the cell treatment module based on the calculated velocity V of the cell and a distance D1 between the detection electrode module and the cell treatment module. a fluidic device comprising a microfluidic channel having an upstream detection zone comprising a detection electrode module configured to detect a change in electrical impedance across the microfluidic channel at the upstream detection zone corresponding to a cell passing the upstream detection zone and a cell treatment zone located downstream of the upstream detection zone and comprising a cell treatment module configured to treat the cell passing the cell treatment zone; a pump fluidically coupled to the fluidic device and configured to pump the population of cells in a carrier liquid unidirectionally along the microfluidic channel; and a processor operatively coupled to the detection electrode module and configured to calculate the velocity V of the cell passing the upstream detection zone based on the change in electrical impedance, and transiently actuate the cell treatment module when the cell reaches the cell treatment module based on the calculated velocity V of the cell and a distance D1 between the detection electrode module and the cell treatment module.
A 3D printing material blend, configured to be used in a 3D printer, comprising: a 3D printing material portion; a magnetic nanoparticle portion; wherein the magnetic nanoparticle portion is embedded in the 3D printing material portion in such a way that the 3D printing material blend is encoded with a uniquely identifiable predetermined code, characterized in that the magnetic nanoparticle portion comprises: (i) a magnetic field amplitude dependent magnetic moment or susceptibility, or (ii) a frequency-dependent magnetic susceptibility, and wherein the predetermined code is related to one or more characteristics of said nanoparticles that affect said magnetic moment or susceptibility. a 3D printing material portion; a magnetic nanoparticle portion; wherein the magnetic nanoparticle portion is embedded in the 3D printing material portion in such a way that the 3D printing material blend is encoded with a uniquely identifiable predetermined code, characterized in that the magnetic nanoparticle portion comprises: (i) a magnetic field amplitude dependent magnetic moment or susceptibility, or (ii) a frequency-dependent magnetic susceptibility, and (i) a magnetic field amplitude dependent magnetic moment or susceptibility, or (ii) a frequency-dependent magnetic susceptibility, and wherein the predetermined code is related to one or more characteristics of said nanoparticles that affect said magnetic moment or susceptibility.
An insert for a run slide for a vehicle window, this insert being intended to be overmoulded to form a connecting wedge between two strands of the run slide, the insert being formed in one piece and comprising first indexing means configured to cooperate with a portion of a door frame of the vehicle intended to be located at an inner side of the vehicle and second indexing means configured to cooperate with a portion of a cover intended to be attached to one of the said strands at the outer side of the vehicle, in which said first means comprise at least one protruding pin configured to be engaged in a notch of a rabbet of the door frame of the vehicle in order to ensure indexing of said insert along an axis X substantially parallel to an axis of elongation of the rabbet, and in which said second means are configured to cooperate by complementary shapes with said portion of the cover in order to ensure indexing of said cover along said axis X and along an axis Z perpendicular to X and substantially parallel to an axis of elongation of said cover.
A ligament prosthesis characterized in that the ligament prosthesis comprises: a plurality of elongate strips that have been cut from a collagen membrane comprising greater than 80% type I collagen and numerous collagen fibres, wherein each elongate strip comprises a plurality of collagen fibres, wherein a majority of the collagen fibres are substantially aligned parallel to each other in a common direction, wherein each collagen fibre has a length, wherein each elongate strip has a length of 2 cm to 20 cm, a thickness of 50 μm to 400 μm, and a width of 50 μm to 5 mm, wherein the lengths of a majority of the plurality of collagen fibres are substantially aligned along the length of the respective elongate strips, wherein the plurality of elongate strips is braided, plaited, woven, twisted or wound together to produce the ligament prosthesis, wherein the ligament prosthesis has a diameter of less than or equal to 10 mm, a cross-sectional area of about 75-80 mm 2 , and is able to withstand a tensile load of 650 N without breaking or suffering any permanent deformation or damage. a plurality of elongate strips that have been cut from a collagen membrane comprising greater than 80% type I collagen and numerous collagen fibres, wherein each elongate strip comprises a plurality of collagen fibres, wherein a majority of the collagen fibres are substantially aligned parallel to each other in a common direction, wherein each collagen fibre has a length, wherein each elongate strip has a length of 2 cm to 20 cm, a thickness of 50 μm to 400 μm, and a width of 50 μm to 5 mm, wherein the lengths of a majority of the plurality of collagen fibres are substantially aligned along the length of the respective elongate strips, wherein the plurality of elongate strips is braided, plaited, woven, twisted or wound together to produce the ligament prosthesis, wherein the ligament prosthesis has a diameter of less than or equal to 10 mm, a cross-sectional area of about 75-80 mm 2 , and is able to withstand a tensile load of 650 N without breaking or suffering any permanent deformation or damage.
Chitosan-nanoclay nanocomposite controlled release system comprising essential oil and nanoclay, for use in the local treatment of infection caused by Helicobacter pylori.
Sliding door fitting for at least two sliding doors that can be placed in parallel, with an upper and a lower sliding rail , each having a guide groove , and with at least two upper and two lower spring sliders for each of the sliding doors , wherein the spring sliders are each formed in one piece from plastic material and each comprise a base body with two opposite longitudinal edges , of which the one, first longitudinal edge is intended to rest on the one groove flank of the guide groove , and a spring arm which is formed on the base body , the free spring arm end of which is intended to rest on the other groove flank of the guide groove , wherein the spring arm can be deflected from a starting position, in which the free spring arm end projects outwards beyond the other, second longitudinal edge , against the action of a restoring force into a less far projecting end position and wherein the distance (b) between the two longitudinal edges of the base body is at most half the size of the groove width (B) of the guide groove such that two compressed spring sliders can be located parallel to one another in the sliding rail .