mhurhangee/patent-ind-claim-en huggingface dataset:
A method for identifying a therapeutic compound effective to reduce invasiveness of fibroblasts characterized by a highly invasive phenotype obtained from a subject with idiopathic pulmonary fibrosis, comprising a. Purifying a population of the fibroblasts characterized by a highly invasive phenotype by: i. Confirming expression of cell surface markers Krtap2-3high and Patched 1 negative by the invasive fibroblasts by flow cytometry; ii. isolating and establishing single cell clones based on expression of the cell surface markers; iii. Transfecting into IPF fibroblasts one or more mammalian expression pcDNA3-XFP vectors selected from the group of Krtap23-GFP, PODXL-RFP, CD127-CFP and PTCH1-mCherry comprising a promoter of Krtap23, PODXL, CD127, or Patched 1 inserted upstream of the fluorescent protein tag; iv. Selecting positive cells of XFP (fluorescent protein) expression; and v. Determining cell marker expression, matrix production, proliferation, survival, migration and invasive capacity of the transfected cells, b. Contacting the population of fibroblasts characterized by the highly invasive phenotype with a prospective therapeutic compound; and c. Reducing invasiveness of the fibroblasts as measured in an invasiveness assay, with minimal impact on normal lung fibroblasts with a non-invasive phenotype. a. Purifying a population of the fibroblasts characterized by a highly invasive phenotype by: i. Confirming expression of cell surface markers Krtap2-3high and Patched 1 negative by the invasive fibroblasts by flow cytometry; ii. isolating and establishing single cell clones based on expression of the cell surface markers; iii. Transfecting into IPF fibroblasts one or more mammalian expression pcDNA3-XFP vectors selected from the group of Krtap23-GFP, PODXL-RFP, CD127-CFP and PTCH1-mCherry comprising a promoter of Krtap23, PODXL, CD127, or Patched 1 inserted upstream of the fluorescent protein tag; iv. Selecting positive cells of XFP (fluorescent protein) expression; and v. Determining cell marker expression, matrix production, proliferation, survival, migration and invasive capacity of the transfected cells, i. Confirming expression of cell surface markers Krtap2-3high and Patched 1 negative by the invasive fibroblasts by flow cytometry; ii. isolating and establishing single cell clones based on expression of the cell surface markers; iii. Transfecting into IPF fibroblasts one or more mammalian expression pcDNA3-XFP vectors selected from the group of Krtap23-GFP, PODXL-RFP, CD127-CFP and PTCH1-mCherry comprising a promoter of Krtap23, PODXL, CD127, or Patched 1 inserted upstream of the fluorescent protein tag; iv. Selecting positive cells of XFP (fluorescent protein) expression; and v. Determining cell marker expression, matrix production, proliferation, survival, migration and invasive capacity of the transfected cells, b. Contacting the population of fibroblasts characterized by the highly invasive phenotype with a prospective therapeutic compound; and c. Reducing invasiveness of the fibroblasts as measured in an invasiveness assay, with minimal impact on normal lung fibroblasts with a non-invasive phenotype.
Oligonucleotide consisting of CAAAGTATTTGGTCTCC (SEQ ID NO. 46), wherein nucleotides in bold letters are LNA modified oligonucleotides, complementary to the TGF-beta2 nucleic acid sequence of SEQ ID NO. 1 of Fig. 2.
A caramel comprising a solid plant fat having a solids content of from 70% to 80% at 10° C, from 50% to 60% at 20° C, from 30% to 40% at 25° C, from 15% to 25% at 30° C, from 8% to 15% at 35°C, and less than 8% at 40° C, and being present in an amount of from 8 to 20 wt % and an amount of water less than 10 wt.% and having an extrusion force of from 3500-8000 gm at 35°C through a 10mm outlet.
A compound of formula (I) wherein X is N or CH; R 1 , R 2 are alkyl, aryl optionally substituted by 1 or 2 halo or heteroaryl optionally substituted by 1 or 2 halo, wherein one of R 1 and R 2 is alkyl; R 3 is halo, alkyl, haloalkyl, hydroxyalkyl, cyano, nitro, -C(O)R 4 , -C(O)NR 5 R 6 ; R 4 is hydrogen, alkyl, aryl, hydroxy, alkoxy or aryloxy; R 5 is hydrogen, alkyl, haloalkyl, hydroxyalkyl, -(CH 2 ) n -cycloalkyl, -(CH 2 ) n -heterocycloalkyl, -(CH 2 ) n -aryl, -(CH 2 ) n -heteroaryl, -(CH 2 ) m -NR 7 R 8 ,-(CH 2 ) m -OR 9 , wherein cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted by one or more halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or oxo; n is an integer from 0 to 6; m is an integer from 2 to 6; R 6 , R 7 , R 8 , R 9 are independently hydrogen, alkyl, or aryl; or R 5 and R 6 together with the nitrogen to which they are bound to form a heterocycloalkyl, or heteroaryl, wherein heterocycloalkyl and heteroaryl are optionally substituted by one or more halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or oxo; and pharmaceutically acceptable salts thereof. X is N or CH; R 1 , R 2 are alkyl, aryl optionally substituted by 1 or 2 halo or heteroaryl optionally substituted by 1 or 2 halo, wherein one of R 1 and R 2 is alkyl; R 3 is halo, alkyl, haloalkyl, hydroxyalkyl, cyano, nitro, -C(O)R 4 , -C(O)NR 5 R 6 ; R 4 is hydrogen, alkyl, aryl, hydroxy, alkoxy or aryloxy; R 5 is hydrogen, alkyl, haloalkyl, hydroxyalkyl, -(CH 2 ) n -cycloalkyl, -(CH 2 ) n -heterocycloalkyl, -(CH 2 ) n -aryl, -(CH 2 ) n -heteroaryl, -(CH 2 ) m -NR 7 R 8 ,-(CH 2 ) m -OR 9 , wherein cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted by one or more halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or oxo; n is an integer from 0 to 6; m is an integer from 2 to 6; R 6 , R 7 , R 8 , R 9 are independently hydrogen, alkyl, or aryl; or R 5 and R 6 together with the nitrogen to which they are bound to form a heterocycloalkyl, or heteroaryl, wherein heterocycloalkyl and heteroaryl are optionally substituted by one or more halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or oxo;
Learning method particular positions of actuators for engaging the gear ratios of a double-clutch gearbox, for a hybrid motor vehicle comprising a heat engine successively driving a primary clutch , a machine electric , then two input clutches of the gearbox each driving a primary shaft , characterized in that when running in freewheel mode comprising the opening of the primary clutch , for learning the engagement of a final gear linked to a final primary shaft (12 ; 22), coming from an engaged initial gear linked to the other initial primary shaft (12 ; 22), it opens the input clutches which are closed, it controls the speed of the electric machine to adjust it to that of the initial primary shaft (12 ; 22), then it closes the clutch of the initial report (Ei), and it then engages the final report by learning the particular positions of the actuator of this final report.
Closure device for a container , in particular a glass container, comprising a container opening , the closure device having a lid element for closing the container opening , a chamber arranged on the lid element , and an inner housing , the chamber and inner housing having mutually corresponding closure means and opening means which interact with one another in such a way that a discharge opening allocated to the chamber can be released by moving the lid element relative to the inner housing , such that a medium stored in the chamber can exit into the container , and the chamber and inner housing each having corresponding first threaded means formed relative to a rotational thread axis , characterised in that the chamber is welded to the lid element , the chamber having an opening that has a collar-like, bent edge region as a connecting flange which is substantially parallel to an adjacent surface of the lid element, and in that the chamber is connected to the lid element along the resultant, annularly formed region.
A lithium secondary battery for an engine starter which can be discharged at -30 degrees centigrade and quickly charged at 25 degrees centigrade by repeatedly occluding and releasing lithium ions in a construction in which an organic electrolytic solution is permeated into a wound or stacked electrode group or said electrode group is immersed in said electrolytic solution with a separator being interposed between a positive electrode having a positive electrode material formed on a metal foil and a negative electrode having a negative electrode material formed on a metal foil, wherein said positive electrode material consists of a mixture of lithium-containing metal phosphate compound particles whose surfaces are coated with an amorphous carbon material and a conductive carbon material, in which atoms of said surface carbon materials are chemically bonded to one another; said negative electrode material contains graphite particles having a specific surface area of not less than 6m 2 /g and soft carbon particles, in which said graphite particles and said soft carbon particles are coated with an amorphous carbon material, and surface carbon atoms of said graphite particles and those of said soft carbon particles are chemically bonded to one another; said metal foil for the positive electrode has a plurality of through-holes, formed therethrough, each having a projected portion on at least one surface thereof; said organic electrolytic solution consists of an organic solvent and a mixed electrolyte dissolved therein, said organic solvent is mixed carbonic acid ester, and said mixed electrolyte contains lithium hexafluorophosphate and lithium bis fluorosulfonyl imide; and said separator consists of a fibrous nonwoven cloth having at least one of a hydrophilic group and oxide ceramics on a surface thereof.
A photovoltaic (PV) device, comprising: a base layer of a semiconducting material of a first conductivity type, the base layer having a first energy bandgap; an emitter layer of a semiconducting material of a second conductivity type opposite the first conductivity type disposed over the base layer, the emitter layer having a second energy bandgap; a base electrical contact in electrical communication with the base layer; and an emitter electrical contact in electrical communication with the emitter layer; and a metal layer disposed over the emitter layer, wherein the first energy bandgap and the second energy bandgap are no less than 3.2 eV, characterised in that the metal layer is optically transparent in the wavelength range from 10 nm to 380 nm, and the device is configured such that the semiconducting material of the emitter layer is exposed to an extreme ultra-violet (EUV) and/or deep ultra-violet (DUV) optical power source through the metal layer; a base layer of a semiconducting material of a first conductivity type, the base layer having a first energy bandgap; an emitter layer of a semiconducting material of a second conductivity type opposite the first conductivity type disposed over the base layer, the emitter layer having a second energy bandgap; a base electrical contact in electrical communication with the base layer; and an emitter electrical contact in electrical communication with the emitter layer; and a metal layer disposed over the emitter layer, wherein the first energy bandgap and the second energy bandgap are no less than 3.2 eV, characterised in that the metal layer is optically transparent in the wavelength range from 10 nm to 380 nm, and the device is configured such that the semiconducting material of the emitter layer is exposed to an extreme ultra-violet (EUV) and/or deep ultra-violet (DUV) optical power source through the metal layer;
An off-shift method for removing soluble iron from a pretreatment bath containing a pretreatment composition comprising a Group IIIB and/or Group IVB metal, comprising: (I) (a) reducing the pH of the pretreatment bath by at least 0.2; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) by at least 0.2, or (II) (a) adding an acid to the pretreatment bath to reduce the pH of the pretreatment composition to below 4.0; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) to 4 to 5.5, wherein the method is performed in the absence of an article to be coated by the pretreatment composition, and wherein the pretreatment bath comprises no more than 30 ppm phosphate ions during operation. (I) (a) reducing the pH of the pretreatment bath by at least 0.2; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) by at least 0.2, or (a) reducing the pH of the pretreatment bath by at least 0.2; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) by at least 0.2, or (II) (a) adding an acid to the pretreatment bath to reduce the pH of the pretreatment composition to below 4.0; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) to 4 to 5.5, (a) adding an acid to the pretreatment bath to reduce the pH of the pretreatment composition to below 4.0; (b) adding phosphate ions to the pretreatment bath in (a); and (c) raising the pH of the pretreatment bath in (b) to 4 to 5.5,
A system for providing an electrical signal conduction pathway in a waterproof manner, the system including: • a first housing portion including an array of openings ; • an electronics connection substrate , coupled to the first housing portion and including a set of electrical contact pads , wherein the set of electrical contact pads of the electronics connection substrate is paired with the array of openings of the first housing portion in a one-to-one manner; characterised in that it further includes: • a set of contacts , composed of an electrically conductive polymer, each contact in the set of contacts having a first region that seals, in a watertight manner, an opening of the array of openings of the first housing portion at an exterior surface of the first housing portion, an intermediate region that passes into the opening of the array of openings , and a second region coupled to an electrical contact pad of the set of electrical contact pads , o wherein each contact in the set of contacts is configured to conduct an electrical signal to at least one electrical contact pad of the electronics connection substrate for signal transmission to an electronics subsystem . • a first housing portion including an array of openings ; • an electronics connection substrate , coupled to the first housing portion and including a set of electrical contact pads , wherein the set of electrical contact pads of the electronics connection substrate is paired with the array of openings of the first housing portion in a one-to-one manner; characterised in that it further includes: • a set of contacts , composed of an electrically conductive polymer, each contact in the set of contacts having a first region that seals, in a watertight manner, an opening of the array of openings of the first housing portion at an exterior surface of the first housing portion, an intermediate region that passes into the opening of the array of openings , and a second region coupled to an electrical contact pad of the set of electrical contact pads , o wherein each contact in the set of contacts is configured to conduct an electrical signal to at least one electrical contact pad of the electronics connection substrate for signal transmission to an electronics subsystem . • a set of contacts , composed of an electrically conductive polymer, each contact in the set of contacts having a first region that seals, in a watertight manner, an opening of the array of openings of the first housing portion at an exterior surface of the first housing portion, an intermediate region that passes into the opening of the array of openings , and a second region coupled to an electrical contact pad of the set of electrical contact pads , o wherein each contact in the set of contacts is configured to conduct an electrical signal to at least one electrical contact pad of the electronics connection substrate for signal transmission to an electronics subsystem .
An in vitro method for classifying prostate cancer in a patient, the method comprising: (a) determining, in a sample from the patient, the mean expression of a panel of genes comprising at least ten cell-cycle genes selected from any one of Panels C-G; and (b) comparing the mean expression to the mean expression level of the same genes in a reference population of patients with the same cancer, wherein elevation of the mean expression relative to the reference population indicates a poor prognosis. (a) determining, in a sample from the patient, the mean expression of a panel of genes comprising at least ten cell-cycle genes selected from any one of Panels C-G; and (b) comparing the mean expression to the mean expression level of the same genes in a reference population of patients with the same cancer,
A fuel injection device comprising: a fuel injection valve for injecting fuel, which is distributed from a common rail ; a pressure sensor located in a fuel passage, which extends from the common rail to a nozzle hole of the fuel injection valve , and configured to detect pressure of the fuel, the pressure sensor being located closer to the nozzle hole than the common rail ; and a storage unit storing individual difference information, which indicates an injection characteristic of the fuel injection valve , the injection characteristic being obtained by an examination consisting in measuring the characteristics for each injector resulting from test-injection, wherein the fuel injection valve is attached with the storage unit , wherein the individual difference information is related to a fluctuation pattern (Pe) of a portion of the fluctuation in detected pressure waveform of the pressure sensor , the fluctuation being attributed to one fuel injection through the nozzle hole , characterized in that the portion of the fluctuation is subsequent to an end of the fuel injection where the injection rate reaches zero. a fuel injection valve for injecting fuel, which is distributed from a common rail ; a pressure sensor located in a fuel passage, which extends from the common rail to a nozzle hole of the fuel injection valve , and configured to detect pressure of the fuel, the pressure sensor being located closer to the nozzle hole than the common rail ; and a storage unit storing individual difference information, which indicates an injection characteristic of the fuel injection valve , the injection characteristic being obtained by an examination consisting in measuring the characteristics for each injector resulting from test-injection, wherein the fuel injection valve is attached with the storage unit , wherein the individual difference information is related to a fluctuation pattern (Pe) of a portion of the fluctuation in detected pressure waveform of the pressure sensor , the fluctuation being attributed to one fuel injection through the nozzle hole , characterized in that the portion of the fluctuation is subsequent to an end of the fuel injection where the injection rate reaches zero.
Cosmetic process for treating keratin materials, comprising the sequential application to the keratin materials of a cosmetic composition comprising a maleic anhydride acrylic polymer and of a polyamine compound or a cosmetic composition containing same, said maleic anhydride acrylic polymer being able to be obtained by polymerization of: (a) 50% to 90% by weight, relative to the total weight of monomers, of isobornyl (meth)acrylate (b) 1 % to 50% by weight of maleic anhydride (c) 0 to 49% by weight of additional (meth)acrylate monomer chosen from: (i) linear or branched, saturated or unsaturated C 1 -C 20 alkyl (meth)acrylates, optionally interrupted with one or more non-adjacent heteroatoms chosen from O and S or with a group NR, R being a C 1 -C 4 alkyl group, optionally substituted with a phenyl or furfuryl group; (ii) saturated C 4 -C 8 cycloalkyl (meth)acrylates optionally interrupted with O or NH; said polyamine compound bearing several primary amine and/or secondary amine groups, the polyamine compound not being an alkoxysilane. (a) 50% to 90% by weight, relative to the total weight of monomers, of isobornyl (meth)acrylate (b) 1 % to 50% by weight of maleic anhydride (c) 0 to 49% by weight of additional (meth)acrylate monomer chosen from: (i) linear or branched, saturated or unsaturated C 1 -C 20 alkyl (meth)acrylates, optionally interrupted with one or more non-adjacent heteroatoms chosen from O and S or with a group NR, R being a C 1 -C 4 alkyl group, optionally substituted with a phenyl or furfuryl group; (ii) saturated C 4 -C 8 cycloalkyl (meth)acrylates optionally interrupted with O or NH; (i) linear or branched, saturated or unsaturated C 1 -C 20 alkyl (meth)acrylates, optionally interrupted with one or more non-adjacent heteroatoms chosen from O and S or with a group NR, R being a C 1 -C 4 alkyl group, optionally substituted with a phenyl or furfuryl group; (ii) saturated C 4 -C 8 cycloalkyl (meth)acrylates optionally interrupted with O or NH;
A capsid assembly inhibitor and peginterferon alpha-2a, wherein the capsid assembly inhibitor is a compound of formula IVc:. or a pharmaceutically acceptable salt thereof; wherein: X is halo; G 1 is hydrogen or halo; G 2 is H, C 1 -C 4 alkyl, or halo; and G 4 is H, halo, C 1 -C 4 alkyl, or OH, for use in a method of treating an HBV infection. X is halo; G 1 is hydrogen or halo; G 2 is H, C 1 -C 4 alkyl, or halo; and G 4 is H, halo, C 1 -C 4 alkyl, or OH,
Leveller for furniture legs comprising: - a casing with a groove , - a mobile piece moving inside the casing and in contact with a support surface - an inner spring , - a spring pressed by the inner spring - anchor pieces formed in the mobile piece , wherein the inner spring and the spring are embedded in the mobile piece wherein - the anchor pieces run through the groove and - the groove is inside a top part of the casing - a casing with a groove , - a mobile piece moving inside the casing and in contact with a support surface - an inner spring , - a spring pressed by the inner spring - anchor pieces formed in the mobile piece , wherein the inner spring and the spring are embedded in the mobile piece wherein wherein the inner spring and the spring are embedded in the mobile piece wherein - the anchor pieces run through the groove and - the groove is inside a top part of the casing
A method for secure operation of a functional module, having a cryptographic algorithm as a function, in an electronic component, the cryptographic algorithm using a key K, and comprising, for each operation of said module, performing the following in random order, - m correct executions of said module, each correct execution comprising executing said algorithm using said key K, and - n dummy executions of said module, each dummy execution comprising executing said algorithm using, respectively, a false key K' 1 , ..., K' n , where m and n are non-zero positive integers, and characterised in that said m+n executions each start at a random point in time. - m correct executions of said module, each correct execution comprising executing said algorithm using said key K, and - n dummy executions of said module, each dummy execution comprising executing said algorithm using, respectively, a false key K' 1 , ..., K' n , where m and n are non-zero positive integers, and characterised in that said m+n executions each start at a random point in time.
A ball bearing cage , with two side rings interconnected by webs , with rolling body pockets being formed in a circumferential direction between the webs , each having a square basic shape with rounded corners, characterised in that the side rings , together with the webs , form a guide contour of each rolling body pocket which comprises between the corners thereof four convex side contours opposing the rounding in the corners.