mhurhangee/patent-ind-claim-en huggingface dataset:
An epidermal growth factor receptor (EGFR) antibody that binds preferentially to disease cells having an EGFR density greater than a normal EGFR density, wherein the disease cells present with more than 10,000 EGFR molecules per cell and the normal cells present with not more than 10,000 EGFR molecules per cell, the EGFR antibody comprising a heavy chain and a light chain, each chain having a constant region and a variable region, each variable region comprising framework region sequences of cetuximab and complementarity determining regions (CDRs), wherein the CDRs have an amino acid sequence set forth below: For the heavy chain: CDR1 NYGVH (SEQ ID No. 1) CDR2 VIWSGGNTD 58 YNTPFTS (SEQ ID No. 2) CDR3 ALTY 101 Y 102 D 103 YE 105 FAY (SEQ ID No. 3) For the light chain: CDR1 RASQSIGTNIH (SEQ ID No. 4) CDR2 ASE 53 SIS (SEQ ID No. 5) CDR3 QQNNNW 94 PTT (SEQ ID No. 6) wherein at least one of E 53 is substituted by K 53 ; D 58 is substituted by N 58 ; W 94 is substituted by A 94 ; Y 101 is substituted by A 101 ; Y 102 is substituted by A 102 ; D 103 is substituted by N 103 ; E 105 is substituted by Q 105 , wherein the substituted amino acid confers on said antibody a reduced EGFR binding affinity (Kd) that is 1.0 nM or weaker, wherein when D 58 is substituted by N 58 this is in combination with D 103 is substituted by N 103 and when E 105 is substituted by Q 105 this is in combination with D 58 being substituted by N 58 and D 103 being substituted by N 103 . For the heavy chain: CDR1 NYGVH (SEQ ID No. 1) CDR2 VIWSGGNTD 58 YNTPFTS (SEQ ID No. 2) CDR3 ALTY 101 Y 102 D 103 YE 105 FAY (SEQ ID No. 3) For the light chain: CDR1 RASQSIGTNIH (SEQ ID No. 4) CDR2 ASE 53 SIS (SEQ ID No. 5) CDR3 QQNNNW 94 PTT (SEQ ID No. 6) wherein at least one of E 53 is substituted by K 53 ; D 58 is substituted by N 58 ; W 94 is substituted by A 94 ; Y 101 is substituted by A 101 ; Y 102 is substituted by A 102 ; D 103 is substituted by N 103 ; E 105 is substituted by Q 105 , wherein the substituted amino acid confers on said antibody a reduced EGFR binding affinity (Kd) that is 1.0 nM or weaker, wherein when D 58 is substituted by N 58 this is in combination with D 103 is substituted by N 103 and when E 105 is substituted by Q 105 this is in combination with D 58 being substituted by N 58 and D 103 being substituted by N 103 .
Borosilicate glass comprising: 75 ∼ 85 wt% of SiO 2 ; 5 ∼ 15 wt% of B 2 O 3 ; 0 ∼ 5 wt% of Al 2 O 3 ; 1 ∼ 7 wt% of R 2 O where R is at least one of Li, Na and K; and < 0.005 wt% of Fe 2 O 3 , wherein the borosilicate glass has a redox ratio of 0.5 ∼ 0.8; and the borosilicate glass further comprises: 0.001 ∼ 0.05 wt% of sulfur. 75 ∼ 85 wt% of SiO 2 ; 5 ∼ 15 wt% of B 2 O 3 ; 0 ∼ 5 wt% of Al 2 O 3 ; 1 ∼ 7 wt% of R 2 O where R is at least one of Li, Na and K; and < 0.005 wt% of Fe 2 O 3 ,
Child car seat, comprising active protection means and means for triggering said active protection means, in case of need, characterised in that said triggering means are carried by said child seat and deliver a command for triggering said active protection means according to a combination of at least two signals: - at least one first signal delivered by a at least one sensor of the locking of said car seat to said vehicle, said sensor of the locking being carried by said seat, and - at least one second signal delivered by detection means, indicating the detection of an accident situation, and in that said active protection means include at least two of the means belonging to the group comprising: - at least one airbag ; - means for blocking or increasing the tension of a "top tether" strap, or anti-tipping strap, intended to fasten an upper portion of said seat and an anchoring point in said vehicle; - means for blocking or increasing the tension of the harness straps of said car seat, intended to maintain a child in said seat; - means for blocking or increasing the tension of a connection strap between a base and a mobile armchair in rotation with respect to said base; - means for uprighting the seatback of said car seat; - means for compressing the child seat on an armchair or a seat of the vehicle, on lower Isofix® anchorings; - means for modifying the inclination of the seat by the intermediary of a support leg. - at least one first signal delivered by a at least one sensor of the locking of said car seat to said vehicle, said sensor of the locking being carried by said seat, and - at least one second signal delivered by detection means, indicating the detection of an accident situation, - at least one airbag ; - means for blocking or increasing the tension of a "top tether" strap, or anti-tipping strap, intended to fasten an upper portion of said seat and an anchoring point in said vehicle; - means for blocking or increasing the tension of the harness straps of said car seat, intended to maintain a child in said seat; - means for blocking or increasing the tension of a connection strap between a base and a mobile armchair in rotation with respect to said base; - means for uprighting the seatback of said car seat; - means for compressing the child seat on an armchair or a seat of the vehicle, on lower Isofix® anchorings; - means for modifying the inclination of the seat by the intermediary of a support leg.
A method of analyzing an incoming telephonic event during an active operative state of a vehicle , the method comprising: activating , by the mobile device and responsive to receiving information indicating an active operative state of the vehicle, an incoming telephonic event analysis application operating on the mobile device; receiving , by the mobile device, an incoming telephonic event at a mobile device associated with a driver of a vehicle; responsive to receiving the incoming telephonic event and based on the active operative state of the vehicle, applying , by the incoming telephonic event analysis application, a soft block to the incoming telephonic event; determining , by the incoming telephonic event analysis application, whether a velocity of the vehicle at a time of receipt of the incoming telephonic event is less than a predetermined velocity threshold; determining , by the incoming telephonic event analysis application, whether the incoming telephonic event is associated with an allowable individual or entity; determining , by the incoming telephonic event analysis application, whether the incoming telephonic event is a first, second, or third incoming telephonic event; and removing , by the incoming telephonic event analysis application and based on at least one of the velocity of the vehicle at the time of receipt of the incoming telephonic event being less than the predetermined velocity threshold, the incoming telephonic event being associated with the allowable individual or entity, and the incoming telephonic event being the third incoming telephonic event, the soft block on the incoming telephonic event. activating , by the mobile device and responsive to receiving information indicating an active operative state of the vehicle, an incoming telephonic event analysis application operating on the mobile device; receiving , by the mobile device, an incoming telephonic event at a mobile device associated with a driver of a vehicle; responsive to receiving the incoming telephonic event and based on the active operative state of the vehicle, applying , by the incoming telephonic event analysis application, a soft block to the incoming telephonic event; determining , by the incoming telephonic event analysis application, whether a velocity of the vehicle at a time of receipt of the incoming telephonic event is less than a predetermined velocity threshold; determining , by the incoming telephonic event analysis application, whether the incoming telephonic event is associated with an allowable individual or entity; determining , by the incoming telephonic event analysis application, whether the incoming telephonic event is a first, second, or third incoming telephonic event; and removing , by the incoming telephonic event analysis application and based on at least one of the velocity of the vehicle at the time of receipt of the incoming telephonic event being less than the predetermined velocity threshold, the incoming telephonic event being associated with the allowable individual or entity, and the incoming telephonic event being the third incoming telephonic event, the soft block on the incoming telephonic event.
A method of preparing a hydrophobic silica aerogel, the method comprising steps of: adding a water glass solution and an acid catalyst to a reactor and performing a reaction to prepare a silica wet gel; adding an inorganic acid and a surface modifier solution to the silica wet gel and performing a surface modification reaction to prepare a hydrophobic silica wet gel; and drying the hydrophobic silica wet gel, wherein the method further comprises adding ammonium hydroxide during the surface modification reaction of step 2; the surface modifier comprises at least one selected from the group consisting of trimethylchlorosilane, hexamethyldisilazane, methyltrimethoxysilane, and trimethylethoxysilane, and wherein, after the entire amount of the surface modifier solution is added, the ammonium hydroxide is added when a pH in the reactor reaches 5 to 10. adding a water glass solution and an acid catalyst to a reactor and performing a reaction to prepare a silica wet gel; adding an inorganic acid and a surface modifier solution to the silica wet gel and performing a surface modification reaction to prepare a hydrophobic silica wet gel; and drying the hydrophobic silica wet gel, wherein the method further comprises adding ammonium hydroxide during the surface modification reaction of step 2; the surface modifier comprises at least one selected from the group consisting of trimethylchlorosilane, hexamethyldisilazane, methyltrimethoxysilane, and trimethylethoxysilane, and wherein, after the entire amount of the surface modifier solution is added, the ammonium hydroxide is added when a pH in the reactor reaches 5 to 10. wherein the method further comprises adding ammonium hydroxide during the surface modification reaction of step 2; the surface modifier comprises at least one selected from the group consisting of trimethylchlorosilane, hexamethyldisilazane, methyltrimethoxysilane, and trimethylethoxysilane, and wherein, after the entire amount of the surface modifier solution is added, the ammonium hydroxide is added when a pH in the reactor reaches 5 to 10.
Tool case having a main element and a lid , wherein the main element and the lid form a case interior space for accommodating at least one hand-held power tool , and having a locking flap for locking the lid to the main element , characterized in that the locking flap has an insert-tool-holding device for holding at least one insert tool .
A method of registering at least one external device on an electronic device , the method comprising: based on a user input for registering at least one external device being received, capturing an image including a plurality of devices through a camera of the electronic device ; obtaining an information on a type of the at least one external device from among the plurality of devices, from the captured image; receiving an information on the at least one external device from the at least one external device; identifying at least one registrable device from among the plurality of devices included in the image , based on the received information from the at least one external device and the obtained information from the captured image; displaying at least one graphic object on the identified at least one registrable device in the image , wherein the at least one graphic object indicates that the at least one registrable device is registrable on the electronic device ; and based on the user input for selecting the at least one graphic object , registering at least one registrable device corresponding to the selected at least one graphic object on the electronic device . based on a user input for registering at least one external device being received, capturing an image including a plurality of devices through a camera of the electronic device ; obtaining an information on a type of the at least one external device from among the plurality of devices, from the captured image; receiving an information on the at least one external device from the at least one external device; identifying at least one registrable device from among the plurality of devices included in the image , based on the received information from the at least one external device and the obtained information from the captured image; displaying at least one graphic object on the identified at least one registrable device in the image , wherein the at least one graphic object indicates that the at least one registrable device is registrable on the electronic device ; and based on the user input for selecting the at least one graphic object , registering at least one registrable device corresponding to the selected at least one graphic object on the electronic device .
Height-adjustable surface box having an upper portion which serves to receive a cover and a lower portion which carries the upper portion , wherein, in order to adjust the height, the upper portion is inserted with a preferably cylindrical pipe portion into the lower portion and can be displaced therein in a telescope-like manner, wherein there are associated with the upper edge of the lower portion inwardly protruding clamping means which for free positioning of the upper portion with respect to the lower portion produce an at least small clamping action between the upper portion and the lower portion , characterised in that the clamping means extend inwards in a flush manner from the upper edge of the lower portion and are constructed as a slotted or segmented circular ring in such a manner that the clamping means as a result of the slotting or segmentation comprise individual radial clamping elements.
A latch assembly for capturing a plug relative to a receptacle, the latch assembly comprising, a housing having a latch compartment and a latch lever compartment and a portal between an exterior of the housing and the latch lever compartment ; a plurality of latches positioned within the latch compartment of the housing and rotatable between a plug capture position and a plug release position; a latch lever pivotably positioned at least partially within the latch lever compartment , the latch lever having a plurality of latch lever arms wherein one latch lever arm corresponds to one of the plurality of latches; and wherein the plurality of latch lever arms extend into the latch compartment and are operatively coupled to the corresponding latch such that pivotable movement of the latch lever is translated to rotational movement of the latches between the plug capture position blocking the portal and the plug release position unblocking the portal. a housing having a latch compartment and a latch lever compartment and a portal between an exterior of the housing and the latch lever compartment ; a plurality of latches positioned within the latch compartment of the housing and rotatable between a plug capture position and a plug release position; a latch lever pivotably positioned at least partially within the latch lever compartment , the latch lever having a plurality of latch lever arms wherein one latch lever arm corresponds to one of the plurality of latches; and wherein the plurality of latch lever arms extend into the latch compartment and are operatively coupled to the corresponding latch such that pivotable movement of the latch lever is translated to rotational movement of the latches between the plug capture position blocking the portal and the plug release position unblocking the portal.
A system for training a neural network for geographical information the neural network ; and a processor operable to generate an environment from actual geographical information, and to simulate a robot moving in the environment to obtain first data from the simulation of the robot, characterised in that : the processor is operable to produce corrupted geographical information from the actual geographical information to obtain second data from the corrupted geographical information, and the neural network is operable to receive the first and the second data, construct predicted geographical information based on the first and second data, and compare the actual geographical information and the predicted geographical information to train the neural network, wherein the neural network is operable to predict at least one region in the actual geographical information that needs to be updated and to construct the predicted geographical information based on information relevant to the at least one region that needs to be updated. the processor is operable to produce corrupted geographical information from the actual geographical information to obtain second data from the corrupted geographical information, and the neural network is operable to receive the first and the second data, construct predicted geographical information based on the first and second data, and compare the actual geographical information and the predicted geographical information to train the neural network, wherein the neural network is operable to predict at least one region in the actual geographical information that needs to be updated and to construct the predicted geographical information based on information relevant to the at least one region that needs to be updated.
A method of performing hopping, which is performed by a first user equipment, UE, in a vehicle-to-something, V2X, communication, the method comprising: transmitting a first message using a first transmission resource; determining a second transmission resource for transmitting a second message by hopping a first hopping unit resource of the first transmission resource according to a predetermined hopping rule; said method being characterized by : dropping at least a part of transmission of the second transmission resource, when the second transmission resource is collided with a k th hopping unit resource of a transmission resource of a second UE, wherein the second transmission resource contains the hopped first hopping unit resource and at least one hopping unit resource contiguous to the hopped first hopping unit resource on a time axis and wherein the variable k corresponds to an integer equal to or greater than 1. transmitting a first message using a first transmission resource; determining a second transmission resource for transmitting a second message by hopping a first hopping unit resource of the first transmission resource according to a predetermined hopping rule; dropping at least a part of transmission of the second transmission resource, when the second transmission resource is collided with a k th hopping unit resource of a transmission resource of a second UE, wherein the second transmission resource contains the hopped first hopping unit resource and at least one hopping unit resource contiguous to the hopped first hopping unit resource on a time axis and wherein the variable k corresponds to an integer equal to or greater than 1.
A recombinant clostridial neurotoxin comprising (i) at least two protein segments consisting of alanine, serine and proline residues, wherein each of said protein segments consists of at least 50 amino acid residues, or (ii) at least two domains having a polyproline II helix conformation, wherein each of said domains comprises an amino acid sequence consisting of at least 50 amino acid residues forming said polyproline II helix conformation.
A headrest comprising: - a headrest frame ; - a speaker unit supported by the headrest frame and including a speaker box , a speaker (52L,R) attached to the speaker box , and a megaphone-shaped tube (54L,R) attached to the speaker box ; - a cushion material ; - a skin material having an opening , sewed into a pouch shape, and covering the headrest frame , the speaker unit , and the cushion material ; and - a ring-shaped member (55L,R) securing the entire opening-side end portion of the skin material sandwiched between the ring-shaped member (55L,R) and the megaphone-shaped tube (54L,R), wherein the megaphone-shaped tube (54L,R) has a flange portion at an end portion on the side opposite the speaker (52L,R), and wherein the ring-shaped member (55R,L) has a tubular portion inserted into and abutted against the megaphone-shaped tube (54L,R) and a flange portion abutted against the flange portion of the megaphone-shaped tube (54L,R), characterized in that : the end portion of the skin material is sandwiched and secured between the flange portion of the megaphone-shaped tube (54L,R) and the flange portion of the ring-shaped member (55L,R). - a headrest frame ; - a speaker unit supported by the headrest frame and including a speaker box , a speaker (52L,R) attached to the speaker box , and a megaphone-shaped tube (54L,R) attached to the speaker box ; - a cushion material ; - a skin material having an opening , sewed into a pouch shape, and covering the headrest frame , the speaker unit , and the cushion material ; and - a ring-shaped member (55L,R) securing the entire opening-side end portion of the skin material sandwiched between the ring-shaped member (55L,R) and the megaphone-shaped tube (54L,R), wherein the megaphone-shaped tube (54L,R) has a flange portion at an end portion on the side opposite the speaker (52L,R), and wherein the ring-shaped member (55R,L) has a tubular portion inserted into and abutted against the megaphone-shaped tube (54L,R) and a flange portion abutted against the flange portion of the megaphone-shaped tube (54L,R), characterized in that : the end portion of the skin material is sandwiched and secured between the flange portion of the megaphone-shaped tube (54L,R) and the flange portion of the ring-shaped member (55L,R).
Device for producing an aerosol for inhalation by a person, comprising a fluid reservoir for a fluid, a nebulizing element provided in order to convert the fluid from the fluid reservoir into an aerosol, and a dispensing tube with a discharge opening along which the aerosol produced is dispensable so that it can be inhaled by a person, wherein the device further comprises a laser provided in order to generate a light beam suitable for irradiating the aerosol during its trajectory through the dispensing tube , wherein the dispensing tube has a length of between 100 mm and 200 mm. and said dispensing tube comprises a tapered part , wherein the discharge opening is provided in the tapered part, in order to create a turbulent flow of the aerosol inside the tube at the level of the transition to the tapered part of the tube, allowing the aerosol to be held in place for a longer period and thus to be irradiated for a longer period.