A method for dropwise topical administration of a liquid composition , comprising the steps of: a) providing a drop dispenser , comprising - a container part with an interior volume partially filled with the liquid composition and a gaseous phase filling the remainder of the interior volume at ambient pressure, the container part having a displaceable section and optionally a substantially stationary section, and - a dropper part in physical connection and in fluid communication with the interior volume of the container part , comprising an outflow channel , connecting the interior volume of the container part to the environment; b) exerting a first force to the displaceable section of the container part of the drop dispenser while holding the drop dispenser in an upright position in which the outflow channel is not in contact with the liquid composition , thereby reducing the interior volume of the container part and forcing the gaseous phase of the interior volume at least partially out of the drop dispenser into the environment; c) inverting the drop dispenser to an inverted position in which the liquid composition is in contact with the outflow channel ; d) releasing said first force from the displaceable section of the container part at least partly, thereby reducing the pressure inside the container part below ambient pressure; and e) exerting a second force to the displaceable section of the container part , while still holding the drop dispenser in the inverted position in which the liquid composition is in contact with the outflow channel , thereby raising the pressure inside the interior volume of the container part above ambient pressure and releasing the liquid composition dropwise from the dropper part of the drop dispenser . a) providing a drop dispenser , comprising - a container part with an interior volume partially filled with the liquid composition and a gaseous phase filling the remainder of the interior volume at ambient pressure, the container part having a displaceable section and optionally a substantially stationary section, and - a dropper part in physical connection and in fluid communication with the interior volume of the container part , comprising an outflow channel , connecting the interior volume of the container part to the environment; - a container part with an interior volume partially filled with the liquid composition and a gaseous phase filling the remainder of the interior volume at ambient pressure, the container part having a displaceable section and optionally a substantially stationary section, and - a dropper part in physical connection and in fluid communication with the interior volume of the container part , comprising an outflow channel , connecting the interior volume of the container part to the environment; b) exerting a first force to the displaceable section of the container part of the drop dispenser while holding the drop dispenser in an upright position in which the outflow channel is not in contact with the liquid composition , thereby reducing the interior volume of the container part and forcing the gaseous phase of the interior volume at least partially out of the drop dispenser into the environment; c) inverting the drop dispenser to an inverted position in which the liquid composition is in contact with the outflow channel ; d) releasing said first force from the displaceable section of the container part at least partly, thereby reducing the pressure inside the container part below ambient pressure; and e) exerting a second force to the displaceable section of the container part , while still holding the drop dispenser in the inverted position in which the liquid composition is in contact with the outflow channel , thereby raising the pressure inside the interior volume of the container part above ambient pressure and releasing the liquid composition dropwise from the dropper part of the drop dispenser . <EOS>