A compound of Formula I: wherein: WisN; X is CR 14 ; R 1 is H or trifluoromethyl; R 2 is NR 7 R 8 , OR 11 , SR 12 , or alkyl; R 3 is H or OR 13 ; R 4 is H or methoxy; R 5 is H, Cl, or trifluoromethyl; R 6 is H or trifluoromethyl; R 7 is H, C 1-5 alkyl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, heterocyclo, aryl, heteroaryl, ureido, thioureido, alkenyl, alkynyl, amido, amino, alkoxy, alkylamino, alkylphosphonate, alkylnitrile, or alkylhalo optionally substituted with C 1-5 alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heteroaryl, alkenyl, alkynyl, amido, alkoxy, alkylamino, alkylhydroxy, halo, hydroxyl, carboxylate, alkylcarboxylate, acylazido, sulfonamide or alkyl halo; R 8 is H, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ureido, thioureido, alkenyl, alkynyl, amido, amino, alkoxy, alkylamino, alkylphosphonate, alkylnitrile, or alkylhalo optionally substituted with C 1-5 alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heteroaryl, alkenyl, alkynyl, amido, alkoxy, alkylhydroxy, halo, hydroxyl, carboxylate, alkylcarboxylate, acylazido, sulfonamide or alkylhalo; R 9 is H, O, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylamino, alkylnitrile or alkylphosphonate optionally substituted with C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or alkylamino; R 10 is H, O, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylamino, alkylnitrile or alkylphosphonate optionally substituted with C 1-5 alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, or alkylamino; R 11 is alkyl, aryl or heteroaryl optionally substituted with alkyl, haloalkyl, aryl or heteroaryl; R 12 is alkyl, aryl or heteroaryl optionally substituted with alkyl, haloalkyl, aryl or heteroaryl; R 13 is alkyl or aryl optionally substituted with alkyl or haloalkyl; and R 14 is H or aryl; or a pharmaceutically acceptable salt thereof, for use in treating acute neural injury, vascular dementia, or central nervous system (CNS) lupus in a subject in need thereof. WisN; X is CR 14 ; R 1 is H or trifluoromethyl; R 2 is NR 7 R 8 , OR 11 , SR 12 , or alkyl; R 3 is H or OR 13 ; R 4 is H or methoxy; R 5 is H, Cl, or trifluoromethyl; R 6 is H or trifluoromethyl; R 7 is H, C 1-5 alkyl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, heterocyclo, aryl, heteroaryl, ureido, thioureido, alkenyl, alkynyl, amido, amino, alkoxy, alkylamino, alkylphosphonate, alkylnitrile, or alkylhalo optionally substituted with C 1-5 alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heteroaryl, alkenyl, alkynyl, amido, alkoxy, alkylamino, alkylhydroxy, halo, hydroxyl, carboxylate, alkylcarboxylate, acylazido, sulfonamide or alkyl halo; R 8 is H, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ureido, thioureido, alkenyl, alkynyl, amido, amino, alkoxy, alkylamino, alkylphosphonate, alkylnitrile, or alkylhalo optionally substituted with C 1-5 alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heteroaryl, alkenyl, alkynyl, amido, alkoxy, alkylhydroxy, halo, hydroxyl, carboxylate, alkylcarboxylate, acylazido, sulfonamide or alkylhalo; R 9 is H, O, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylamino, alkylnitrile or alkylphosphonate optionally substituted with C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl or alkylamino; R 10 is H, O, C 1-5 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkylamino, alkylnitrile or alkylphosphonate optionally substituted with C 1-5 alkyl, cycloalkyl, heterocycloalkyl, heteroaryl, or alkylamino; R 11 is alkyl, aryl or heteroaryl optionally substituted with alkyl, haloalkyl, aryl or heteroaryl; R 12 is alkyl, aryl or heteroaryl optionally substituted with alkyl, haloalkyl, aryl or heteroaryl; R 13 is alkyl or aryl optionally substituted with alkyl or haloalkyl; and R 14 is H or aryl; or a pharmaceutically acceptable salt thereof, for use in treating acute neural injury, vascular dementia, or central nervous system (CNS) lupus in a subject in need thereof. <EOS>