A biopsy device , comprising: a housing body defining a longitudinal axis ; a cannula assembly having an actuator body and an elongate cannula affixed to the actuator body , the elongate cannula having a side wall (58-3) defining a lumen (58-4), and having a vacuum side port (58-5) that extends through the side wall (58-3) and in fluid communication with the lumen (58-4); the actuator body having a drive tab (54-1) and a proximal latch mechanism (54-2), the proximal latch mechanism (54-2) configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; a cannula drive spring coupled between the housing body and the actuator body , the cannula drive spring configured to be compressed when the proximal latch mechanism (54-2) is moved to the retracted position and configured to decompress to propel the elongate cannula in a distal direction (D1) when the proximal latch mechanism (54-2) is released from the retracted position; a vacuum source coupled to the housing body and configured to store a vacuum, the vacuum source including a vacuum chamber housing having a chamber open end , a chamber end wall , a chamber side wall extending between the chamber open end and the chamber end wall , and a chamber vacuum port (76-3); and a trigger slide assembly having a slider body operatively coupled to the drive tab (54-1) of the cannula assembly and to the vacuum source characterized in that the chamber side wall of the vacuum chamber housing has a perimeter defining a U-shaped area in cross-section that extends longitudinally between the chamber open end and the chamber end wall to define a U-shaped volume (76-2). a housing body defining a longitudinal axis ; a cannula assembly having an actuator body and an elongate cannula affixed to the actuator body , the elongate cannula having a side wall (58-3) defining a lumen (58-4), and having a vacuum side port (58-5) that extends through the side wall (58-3) and in fluid communication with the lumen (58-4); the actuator body having a drive tab (54-1) and a proximal latch mechanism (54-2), the proximal latch mechanism (54-2) configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; the elongate cannula having a side wall (58-3) defining a lumen (58-4), and having a vacuum side port (58-5) that extends through the side wall (58-3) and in fluid communication with the lumen (58-4); the actuator body having a drive tab (54-1) and a proximal latch mechanism (54-2), the proximal latch mechanism (54-2) configured to selectively engage the housing body to releasably latch the cannula assembly in a retracted position; a cannula drive spring coupled between the housing body and the actuator body , the cannula drive spring configured to be compressed when the proximal latch mechanism (54-2) is moved to the retracted position and configured to decompress to propel the elongate cannula in a distal direction (D1) when the proximal latch mechanism (54-2) is released from the retracted position; a vacuum source coupled to the housing body and configured to store a vacuum, the vacuum source including a vacuum chamber housing having a chamber open end , a chamber end wall , a chamber side wall extending between the chamber open end and the chamber end wall , and a chamber vacuum port (76-3); and a trigger slide assembly having a slider body operatively coupled to the drive tab (54-1) of the cannula assembly and to the vacuum source characterized in that the chamber side wall of the vacuum chamber housing has a perimeter defining a U-shaped area in cross-section that extends longitudinally between the chamber open end and the chamber end wall to define a U-shaped volume (76-2). <EOS>