A method for producing a filler containing a PLLA-HA double microcapsule comprising: (a) mixing PLLA (poly-L-lactic acid) with CMC (carboxymethylcellulose) and mannitol, freeze-drying a resulting mixture, pulverizing the freeze-dried mixture to a certain size, and sterilizing a result thereof using gamma radiation to prepare a PLLA mixture; (b) mixing HA (hyaluronic acid) with a BDDE (butanediol diglycidyl ether) crosslinking agent, gelling a resulting mixture, washing a resulting gel with a phosphate buffer, collecting crosslinked HA with uniform particles and passing the HA through a screen to obtain crosslinked HA with uniform particles to thereby prepare a HA mixture; (c) homogenizing a primary core material (W 1 ) containing a bioactive material, the PLLA mixture obtained in step (a), a biodegradable polymer, MCT (medium-chain triglyceride) oil and PGPR (polyglycerol polyricinoleate) to obtain a primary emulsion (W 1 /O), wherein the biodegradable polymer comprises at least one selected from the group consisting of polydioxanone, poly-(ε-caprolactone), poly(lactic-co-glycolic acid), polylactide-co-ε-caprolactone, poly-L-lactide, polylactic acid, polyglycolic acid, polyhydroxy-valeric acid, polyphosphoester, polyethylene oxide-polylactic acid, polyethylene oxide-polylactic-co-glycolic acid, polyethylene oxide-poly-ε-caprolactone, poly-4-hydroxybutyrate, and chitosan; (d) adding distilled water to the crosslinked HA to obtain a secondary wall material (W 2 ); (e) mixing the primary emulsion (W 1 /O) with the secondary wall material (W 2 ) to obtain a PLLA-HA W/O/W emulsion; and (f) spray-drying the PLLA-HA W/O/W emulsion to prepare a double microcapsule, wherein the spray-drying is performed under the condition that the fed air temperature is between 125 °C to 135 °C, the discharge air temperature is between 75 °C to 85 °C, the rotary sprayer is 10x10 kPa, the blower speed is 0.80 m 3 /min and the pump speed is 1.0 mL/min. (a) mixing PLLA (poly-L-lactic acid) with CMC (carboxymethylcellulose) and mannitol, freeze-drying a resulting mixture, pulverizing the freeze-dried mixture to a certain size, and sterilizing a result thereof using gamma radiation to prepare a PLLA mixture; (b) mixing HA (hyaluronic acid) with a BDDE (butanediol diglycidyl ether) crosslinking agent, gelling a resulting mixture, washing a resulting gel with a phosphate buffer, collecting crosslinked HA with uniform particles and passing the HA through a screen to obtain crosslinked HA with uniform particles to thereby prepare a HA mixture; (c) homogenizing a primary core material (W 1 ) containing a bioactive material, the PLLA mixture obtained in step (a), a biodegradable polymer, MCT (medium-chain triglyceride) oil and PGPR (polyglycerol polyricinoleate) to obtain a primary emulsion (W 1 /O), wherein the biodegradable polymer comprises at least one selected from the group consisting of polydioxanone, poly-(ε-caprolactone), poly(lactic-co-glycolic acid), polylactide-co-ε-caprolactone, poly-L-lactide, polylactic acid, polyglycolic acid, polyhydroxy-valeric acid, polyphosphoester, polyethylene oxide-polylactic acid, polyethylene oxide-polylactic-co-glycolic acid, polyethylene oxide-poly-ε-caprolactone, poly-4-hydroxybutyrate, and chitosan; (d) adding distilled water to the crosslinked HA to obtain a secondary wall material (W 2 ); (e) mixing the primary emulsion (W 1 /O) with the secondary wall material (W 2 ) to obtain a PLLA-HA W/O/W emulsion; and (f) spray-drying the PLLA-HA W/O/W emulsion to prepare a double microcapsule, <EOS>