A method of manufacturing the calcium nanohydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 structurally modified with Li + ions (nHAP:Li + ) Li 0,1 Ca 9,9 (PO 4 ) 6 (OH) 2 optionally doped with 1-2% mol of Eu 3+ cations in the form of nanocrystalline powder, characterized in that it consists of seven steps, where: in step one the water soluble lithium nitrate is obtained by digestion of the stoichiometric amount of Li 2 CO 3 in an excess of HNO 3 ; in step two depending on the final product which is obtained the solution of water soluble calcium nitrate is obtained by suspension of 73,35 g of Ca(OH) 2 in 200 ml of deionized water and subsequent digestion of calcium dioxide in an excess of 65% HNO 3 and 170 g of polyvinylpyrrolidone is added or the pure europium (III) nitrate is obtained by suspending stoichiometric amounts 0,0352 g of Eu 2 O 3 in distilled water and subsequent digestion of europium oxide in an excess of 65% HNO 3 and subsequent three times re-crystallization and solution of 2.2434 g of Ca(NO 3 ) 2 ·4H 2 O dissolved in MQ-water is added; in step three the ammonium phosphate solution is obtained by dissolution of (NH 4 ) 2 HPO 4 in water in step four solutions prepared in the steps 1-2 are added to the ammonium phosphate solution obtained in step 3, leading to fast precipitation of the by-product; in step five the pH is adjusted to 8-10 by addition of ammonium hydroxide NH 4 OH and the mixture is filtrated under reduced pressure; in step six the precipitate resulted in step 5 is washed 5 times and dried at 90°C for 20-24 h; in step seven the precipitate resulted in step 6 is subjected to a thermal treatment by gradually heating at 400-500°C in air atmosphere for 3-4 hours, at a heating rate of 5°C per minute to obtain final product. in step one the water soluble lithium nitrate is obtained by digestion of the stoichiometric amount of Li 2 CO 3 in an excess of HNO 3 ; in step two depending on the final product which is obtained the solution of water soluble calcium nitrate is obtained by suspension of 73,35 g of Ca(OH) 2 in 200 ml of deionized water and subsequent digestion of calcium dioxide in an excess of 65% HNO 3 and 170 g of polyvinylpyrrolidone is added or the pure europium (III) nitrate is obtained by suspending stoichiometric amounts 0,0352 g of Eu 2 O 3 in distilled water and subsequent digestion of europium oxide in an excess of 65% HNO 3 and subsequent three times re-crystallization and solution of 2.2434 g of Ca(NO 3 ) 2 ·4H 2 O dissolved in MQ-water is added; in step three the ammonium phosphate solution is obtained by dissolution of (NH 4 ) 2 HPO 4 in water in step four solutions prepared in the steps 1-2 are added to the ammonium phosphate solution obtained in step 3, leading to fast precipitation of the by-product; in step five the pH is adjusted to 8-10 by addition of ammonium hydroxide NH 4 OH and the mixture is filtrated under reduced pressure; in step six the precipitate resulted in step 5 is washed 5 times and dried at 90°C for 20-24 h; in step seven the precipitate resulted in step 6 is subjected to a thermal treatment by gradually heating at 400-500°C in air atmosphere for 3-4 hours, at a heating rate of 5°C per minute to obtain final product. <EOS>