mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody or a fragment thereof, having a variable region which binds a target molecule, and a constant region, wherein the constant region comprises one or more mutations introducing a site specific conjugation site selected so as to permit conjugation of the antibody or fragment to a payload, wherein the one or more mutations include a mutation at light chain position 208, wherein the mutated residue at light chain position 208 is cysteine, wherein the antibody is selected from the group comprising IgG1, IgG2, IgG3, and IgG4.
Terlipressin or salt thereof for use in the treatment of ascites due to liver cirrhosis in an ascites patient, wherein the terlipressin or salt thereof is administered as a continuous infusion dose in the range from 1.0 mg to 12.0 mg per day for one day to 12 months, and wherein the condition of the patient has not progressed to hepatorenal syndrome.
A guide compound targeted to a genomic DNA, comprising a target guide chain of 14-24 contiguous monomers attached to a CRISPR RNA (crRNA), wherein the guide compound directs allele-selective CRISPR gene editing of the genomic DNA, wherein the monomers comprise UNA monomers and nucleic acid monomers, wherein each UNA monomer independently has a structure of where R 1 and R 2 are each independently H or a phosphodiester linkage, Base is a nucleobase, and R 3 is -OR 4 , -SR 4 , -NR 4 2 , -NH(C=O)R 4 , morpholino, morpholin-l-yl, piperazin-l-yl, or 4-alkanoyl-piperazin-l-yl, where each R 4 is independently selected from H, alkyl, a cholesterol, a lipid molecule, a polyamine, an amino acid, and a polypeptide, and wherein the guide compound comprises a sequence of bases targeted to direct CRISPR gene editing of the genomic DNA.
A urethane adhesive composition comprising: a urethane prepolymer having an isocyanate group; an isocyanurate compound of pentamethylene diisocyanate and/or hexamethylene diisocyanate; and a secondary aminosilane compound, a terpene compound, wherein the terpene compound comprises a phenolic derivative of the terpene; and an isocyanate silane compound. a urethane prepolymer having an isocyanate group; an isocyanurate compound of pentamethylene diisocyanate and/or hexamethylene diisocyanate; and a secondary aminosilane compound, a terpene compound, wherein the terpene compound comprises a phenolic derivative of the terpene; and an isocyanate silane compound.
A worm gear for an electromechanical power steering system of a motor vehicle, comprising a worm shaft which meshes with a worm wheel via a worm drive , wherein the worm wheel and the worm shaft are arranged together in a gear housing , characterized in that an eccentric lever and a bimetallic spring that is operatively connected with the eccentric lever compensate for a temperature-related play in the engagement between the worm wheel and the worm shaft , wherein a wedge element is provided between the gear housing and the bimetallic spring , which wedge element is braced against a stop pin on the gear housing , and that the wedge element is arranged between the gear housing and the eccentric lever , such that the eccentric lever can be moved toward the worm wheel or moved away from the worm wheel by moving the wedge element .
An apparatus comprising: a power-factor correction, PFC, circuit coupleable to a primary load that exhibits a change in resistance with a change in applied voltage, the respective voltage being a primary-load voltage, and current through the primary load being a primary-load current; and characterised in that the PFC circuit is configured to provide an auxiliary load and control current therethrough, the respective current being an auxiliary-load current, the PFC circuit being configured to control the auxiliary-load current such that the sum of the primary-load current and auxiliary-load current is a constant proportion of the primary-load voltage, the respective sum being a sum current. a power-factor correction, PFC, circuit coupleable to a primary load that exhibits a change in resistance with a change in applied voltage, the respective voltage being a primary-load voltage, and current through the primary load being a primary-load current; and characterised in that the PFC circuit is configured to provide an auxiliary load and control current therethrough, the respective current being an auxiliary-load current, the PFC circuit being configured to control the auxiliary-load current such that the sum of the primary-load current and auxiliary-load current is a constant proportion of the primary-load voltage, the respective sum being a sum current.
A riding grass mower comprising: a traveling vehicle body with a hydraulic oil supply source ; a mower device provided at a lower portion of the traveling vehicle body ; a grass collecting container configured to be detachably supported to the traveling vehicle body ; a plurality of hydraulic cylinders configured to raise and lower the grass collecting container and to change an orientation of the grass collecting container ; a hydraulic oil supply/discharge passage extending from the hydraulic oil supply source provided in the traveling vehicle body to the plurality of hydraulic cylinders ; a valve provided in said hydraulic oil supply/discharge passage and configured to control supply and discharge of hydraulic oil to and from the hydraulic cylinders; and a coupler that is configured to be capable of connecting and disconnecting the hydraulic oil supply/discharge passage , wherein a rollover protection structure (ROPS) is provided upright at a rear end portion of the traveling vehicle body , wherein the grass collecting container is detachably supported to the ROPS ; the riding grass mower being characterized in that the valve is an electromagnetic valve , in that the coupler is provided between the hydraulic oil supply source and the electromagnetic valve , in that the electromagnetic valve is supported to the traveling vehicle body via a holder device , and the holder device is configured to enable attachment and detachment of the electromagnetic valve to and from the traveling vehicle body , and in that the holder device is provided in the ROPS . a traveling vehicle body with a hydraulic oil supply source ; a mower device provided at a lower portion of the traveling vehicle body ; a grass collecting container configured to be detachably supported to the traveling vehicle body ; a plurality of hydraulic cylinders configured to raise and lower the grass collecting container and to change an orientation of the grass collecting container ; a hydraulic oil supply/discharge passage extending from the hydraulic oil supply source provided in the traveling vehicle body to the plurality of hydraulic cylinders ; a valve provided in said hydraulic oil supply/discharge passage and configured to control supply and discharge of hydraulic oil to and from the hydraulic cylinders; and a coupler that is configured to be capable of connecting and disconnecting the hydraulic oil supply/discharge passage , wherein a rollover protection structure (ROPS) is provided upright at a rear end portion of the traveling vehicle body , wherein the grass collecting container is detachably supported to the ROPS ; the riding grass mower being characterized in that the valve is an electromagnetic valve , in that the coupler is provided between the hydraulic oil supply source and the electromagnetic valve , in that the electromagnetic valve is supported to the traveling vehicle body via a holder device , and the holder device is configured to enable attachment and detachment of the electromagnetic valve to and from the traveling vehicle body , and in that the holder device is provided in the ROPS .
A curable film-forming composition comprising: (a) an acrylic polyol prepared from a monomer mixture comprising a hydroxyl functional monomer, wherein the hydroxyl functional monomer comprises a hydroxyalkyl group with an alkyl chain of at least four carbon atoms; (b) a rheology modifier comprising: a non-aqueous dispersion of an internally crosslinked organic polymer; and a reaction product of an amine and an isocyanate; and (c) a curing agent comprising functional groups that are reactive with hydroxyl functional groups. (a) an acrylic polyol prepared from a monomer mixture comprising a hydroxyl functional monomer, wherein the hydroxyl functional monomer comprises a hydroxyalkyl group with an alkyl chain of at least four carbon atoms; (b) a rheology modifier comprising: a non-aqueous dispersion of an internally crosslinked organic polymer; and a reaction product of an amine and an isocyanate; and a non-aqueous dispersion of an internally crosslinked organic polymer; and a reaction product of an amine and an isocyanate; and (c) a curing agent comprising functional groups that are reactive with hydroxyl functional groups.
A medical device for electrical stimulation, the medical device comprising: an electric circuitry configured to perform active charge compensation, said electric circuitry being connectable to at least one electrode arrangement for electrical stimulation, wherein the electric circuitry includes: monitoring means configured to monitor at least one voltage associated with a stimulation network ; at least one variable resistive element configured to provide a voltage drop used in the active charge compensation; and adjustment means configured to dynamically adjust a resistance value of the at least one variable resistive element during the active charge compensation based on the at least monitored voltage, wherein the adjustment means is a finite state machine for neurostimulation. an electric circuitry configured to perform active charge compensation, said electric circuitry being connectable to at least one electrode arrangement for electrical stimulation, wherein the electric circuitry includes: monitoring means configured to monitor at least one voltage associated with a stimulation network ; at least one variable resistive element configured to provide a voltage drop used in the active charge compensation; and adjustment means configured to dynamically adjust a resistance value of the at least one variable resistive element during the active charge compensation based on the at least monitored voltage, wherein the adjustment means is a finite state machine for neurostimulation. monitoring means configured to monitor at least one voltage associated with a stimulation network ; at least one variable resistive element configured to provide a voltage drop used in the active charge compensation; and adjustment means configured to dynamically adjust a resistance value of the at least one variable resistive element during the active charge compensation based on the at least monitored voltage, wherein the adjustment means is a finite state machine for neurostimulation.
A control method for an HVAC system in a relatively large spatial place, wherein the HVAC system comprises an air handling unit , and the air handling unit is provided with a valve through which a fluid medium passes and a fan ; and the method comprises: monitoring a return air temperature of air circulated back to the air handling unit; providing a return air temperature setpoint of the HVAC system; performing decoupling adjustment on one of the fan and the valve, and then adjusting the other of the fan and the valve so that the return air temperature is close to the return air temperature setpoint; wherein an opening degree adjustment of the valve is determined based on a supply air temperature of air leaving the air handling unit and a supply air temperature setpoint of the HVAC system; characterized in that : adjustment on the fan and the valve comprises decreasing the opening degree of the valve after decreasing a speed of the fan to a minimum value. monitoring a return air temperature of air circulated back to the air handling unit; providing a return air temperature setpoint of the HVAC system; performing decoupling adjustment on one of the fan and the valve, and then adjusting the other of the fan and the valve so that the return air temperature is close to the return air temperature setpoint; wherein an opening degree adjustment of the valve is determined based on a supply air temperature of air leaving the air handling unit and a supply air temperature setpoint of the HVAC system; characterized in that : adjustment on the fan and the valve comprises decreasing the opening degree of the valve after decreasing a speed of the fan to a minimum value.
A photo- or redox-cleavable amphiphilic copolymer compound of formula (I): Where: R 1 , R 2 , R 3 R 4 and R 5 substitution groups on the pyridinium ring are chosen from H, OH, OMethyl, CN, NR 2 , NO 2 , halogen, or two adjacent R 1 , R 2 , R 3 R 4 and R 5 are linked together to form one or more aromatic rings fused with the pyridinium ring to which they are attached so as to form an optionally substituted bi-cyclic quinolinium or optionally substituted fused tri-cyclic N-containing heteroaryl (e.g. acridinium), R 6 is H or an alkyl group; R 7 is O, or alkylene; R 8 and R 9 identical or different are independently chosen from H, alkyl, aryl or benzyl, preferably methyl or benzyl; Where the optional substituents are chosen from OH, OMethyl, CN, NO 2 , NR 2 , halogen; R represents H, phenyl or a methyl group; n 1 and n 3 are identical or different integers comprised between 0 and 5 defining the length of the spacer; n 2 is an integer comprised between 34 and 80 denoting the polymerization degree of ethylene oxide in the hydrophilic block of the amphiphilic copolymer; n 4 is an integer chosen between 18 and 40 denoting the polymerization degree of γ-benzyl- L -glutamate in the hydrophobic block of the amphiphilic copolymer; X - is a halide or a trifluoromethanesulfonate (OTf), phosphate, sulfate, perchlorate or nitrate counterion. R 1 , R 2 , R 3 R 4 and R 5 substitution groups on the pyridinium ring are chosen from H, OH, OMethyl, CN, NR 2 , NO 2 , halogen, or two adjacent R 1 , R 2 , R 3 R 4 and R 5 are linked together to form one or more aromatic rings fused with the pyridinium ring to which they are attached so as to form an optionally substituted bi-cyclic quinolinium or optionally substituted fused tri-cyclic N-containing heteroaryl (e.g. acridinium), R 6 is H or an alkyl group; R 7 is O, or alkylene; R 8 and R 9 identical or different are independently chosen from H, alkyl, aryl or benzyl, preferably methyl or benzyl; Where the optional substituents are chosen from OH, OMethyl, CN, NO 2 , NR 2 , halogen; R represents H, phenyl or a methyl group; n 1 and n 3 are identical or different integers comprised between 0 and 5 defining the length of the spacer; n 2 is an integer comprised between 34 and 80 denoting the polymerization degree of ethylene oxide in the hydrophilic block of the amphiphilic copolymer; n 4 is an integer chosen between 18 and 40 denoting the polymerization degree of γ-benzyl- L -glutamate in the hydrophobic block of the amphiphilic copolymer; X - is a halide or a trifluoromethanesulfonate (OTf), phosphate, sulfate, perchlorate or nitrate counterion.
A communication method, comprising: receiving (S201), by a session management function, SMF, entity, a packet data unit, PDU, session establishment request from user equipment, UE ; wherein the PDU session establishment request comprises an SM security service capability of the UE , and the SM security service capability of the UE is used to indicate an SM security service procedure supported by the UE ; sending (S202), by the SMF entity , a second request message to a storage function entity based on the PDU session establishment request, wherein the second request message is used to request a session management, SM, security service identifier for the UE , and the SM security service identifier is used to indicate an SM security service procedure; receiving (S203), by the SMF entity, a response message from the storage function entity, wherein the response message comprises the SM security service identifier; wherein the SMF SM security service identifier is used to indicate a further SM security service procedure to be initiated by the SMF entity ; obtaining (S204), by the SMF entity , an SMF SM security service identifier based on the SM security service identifier and the SM security service capability of the UE ; and initiating (S205), by the SMF entity , the further SM security service procedure indicated by the SMF SM security service identifier. receiving (S201), by a session management function, SMF, entity, a packet data unit, PDU, session establishment request from user equipment, UE ; wherein the PDU session establishment request comprises an SM security service capability of the UE , and the SM security service capability of the UE is used to indicate an SM security service procedure supported by the UE ; sending (S202), by the SMF entity , a second request message to a storage function entity based on the PDU session establishment request, wherein the second request message is used to request a session management, SM, security service identifier for the UE , and the SM security service identifier is used to indicate an SM security service procedure; receiving (S203), by the SMF entity, a response message from the storage function entity, wherein the response message comprises the SM security service identifier; wherein the SMF SM security service identifier is used to indicate a further SM security service procedure to be initiated by the SMF entity ; obtaining (S204), by the SMF entity , an SMF SM security service identifier based on the SM security service identifier and the SM security service capability of the UE ; and initiating (S205), by the SMF entity , the further SM security service procedure indicated by the SMF SM security service identifier.
An accommodative multifocal intraocular lens, comprising an optical body , two haptics and two silicone connecting members , the silicone connecting members being located between the optical body and the haptics , and connecting the optical body and the haptics in an inserted manner through recesses and projections; wherein two ends along a width of each silicone connecting member are each provided with projections ; wherein two ends of the optical body are each provided with a recess ; wherein an end, joined to the optical body , of each haptic is provided with a recess ; wherein the projections of each silicone connecting member are inserted into the corresponding recesses of the optical body and the haptic ; wherein the silicone connecting members are connected to the optical body and the haptics by means of glue; and wherein the optical zone of the optical body is an optical zone having two focal points, three focal points, an infinite zoom region or regional multifocal points.
An isocyanate-modified polyester-epoxide polymer (i-PEEP) composition which comprises a reaction product of: (a) a polyepoxide compound having an equivalent weight within the range of 125 to 250 g/eq.; (b) a polyol composition comprising a polyester polyol, wherein the polyester polyol has a hydroxyl value within the range of 50 to 400 mg KOH/g, an average hydroxyl functionality within the range of 1.5 to 4.0, and an acid number less than 5 mg KOH/g; and (c) a polyisocyanate having an average NCO functionality within the range of 2.0 to 3.0; wherein the polyepoxide compound is an aromatic polyepoxide; and wherein the ratio of epoxy equivalents of the polyepoxide compound to hydroxyl equivalents of the polyol composition is within the range of 0.2 to 2, the i-PEEP index as defined herein is within the range of 100 to 200; and the i-PEEP composition has a glass-transition temperature as measured by differential scanning calorimetry within the range of -30°C to 35°C. (a) a polyepoxide compound having an equivalent weight within the range of 125 to 250 g/eq.; (b) a polyol composition comprising a polyester polyol, wherein the polyester polyol has a hydroxyl value within the range of 50 to 400 mg KOH/g, an average hydroxyl functionality within the range of 1.5 to 4.0, and an acid number less than 5 mg KOH/g; and (c) a polyisocyanate having an average NCO functionality within the range of 2.0 to 3.0; wherein the polyepoxide compound is an aromatic polyepoxide; and wherein the ratio of epoxy equivalents of the polyepoxide compound to hydroxyl equivalents of the polyol composition is within the range of 0.2 to 2, the i-PEEP index as defined herein is within the range of 100 to 200; and the i-PEEP composition has a glass-transition temperature as measured by differential scanning calorimetry within the range of -30°C to 35°C.
Power take-off, PTO, assembly for a work vehicle, said PTO assembly comprising: - at least one output shaft ; - at least one clutch, which is configured to selectively couple said output shaft to a mechanical power source of said work vehicle; and - at least one brake, which is configured to impart a braking torque to said output shaft ; and - a hydraulic arrangement comprising: - a brake line configured to fluidly connect a source of pressurized fluid of said work vehicle to said at least one brake; and - a clutch line configured to fluidly connect said source to said at least one clutch; said hydraulic arrangement further comprising valve means , which are configured to control the flow of fluid between said source , said brake line and said clutch line ; wherein said valve means comprises a spool , said spool has at least a first configuration wherein it allows the passage of fluid from said source to said brake line and a second configuration wherein it allows the passage of fluid from said source to said clutch line , said PTO assembly is characterized in that in both said first and second configurations said valve means define a conduit for the leakage flow configured to be directed to operational elements of said PTO assembly for lubrication thereof. - at least one output shaft ; - at least one clutch, which is configured to selectively couple said output shaft to a mechanical power source of said work vehicle; and - at least one brake, which is configured to impart a braking torque to said output shaft ; and - a hydraulic arrangement comprising: - a brake line configured to fluidly connect a source of pressurized fluid of said work vehicle to said at least one brake; and - a clutch line configured to fluidly connect said source to said at least one clutch; said hydraulic arrangement further comprising valve means , which are configured to control the flow of fluid between said source , said brake line and said clutch line ; wherein said valve means comprises a spool , said spool has at least a first configuration wherein it allows the passage of fluid from said source to said brake line and a second configuration wherein it allows the passage of fluid from said source to said clutch line ,
A process for manufacturing a vaccine comprising steps of: (i) isolating an influenza virus from a patient sample, comprising a step in which the patient sample is incubated with a MDCK cell, wherein the MDCK cell is growing in a serum-free suspension culture, and (ii) manufacturing a vaccine from the influenza virus isolated in step (i), wherein the influenza virus is not grown in eggs before being exposed to MDCK cells, and wherein after isolation, the virus is not subsequently grown in eggs. (i) isolating an influenza virus from a patient sample, comprising a step in which the patient sample is incubated with a MDCK cell, wherein the MDCK cell is growing in a serum-free suspension culture, and (ii) manufacturing a vaccine from the influenza virus isolated in step (i),