mhurhangee/patent-ind-claim-en huggingface dataset:
A system comprising: a port configured to receive an indication of dosing of medication to treat a pulmonary condition of a heart failure, HF, subject, the medication being a corticosteroid; at least one sensing circuit configured to sense at least one physiological signal, wherein the physiological signal includes physiological information of the HF subject; at least one processor including: a parameter module configured to extract values of at least one physiological parameter indicative of health status of the HF subject; and a trending module configured to detect a side effect of the dosing of the corticosteroid by detecting an amplitude of S3 heart sound exceeding a predefined threshold, or by detecting an increase, within a specified time period, of one or more of heart rate, arrhythmias as determined by monitoring arrhythmia burden and/or ventricular rate during arrhythmia, heart contractility as determined by monitoring S1, and the amplitude of S1 or S2 exceeding a predefined threshold; and the system further including a therapy circuit configured to control delivery of drug therapy to the HF subject, and wherein the at least one processor is configured to initiate at least one of delivery of drug therapy or a change in a parameter of the drug therapy in response to detection of the side effect of the dosing of the medication on the HF subject. a port configured to receive an indication of dosing of medication to treat a pulmonary condition of a heart failure, HF, subject, the medication being a corticosteroid; at least one sensing circuit configured to sense at least one physiological signal, wherein the physiological signal includes physiological information of the HF subject; at least one processor including: a parameter module configured to extract values of at least one physiological parameter indicative of health status of the HF subject; and a trending module configured to detect a side effect of the dosing of the corticosteroid by detecting an amplitude of S3 heart sound exceeding a predefined threshold, or by detecting an increase, within a specified time period, of one or more of heart rate, arrhythmias as determined by monitoring arrhythmia burden and/or ventricular rate during arrhythmia, heart contractility as determined by monitoring S1, and the amplitude of S1 or S2 exceeding a predefined threshold; and the system further including a therapy circuit configured to control delivery of drug therapy to the HF subject, and wherein the at least one processor is configured to initiate at least one of delivery of drug therapy or a change in a parameter of the drug therapy in response to detection of the side effect of the dosing of the medication on the HF subject.
An amino-modified chip, comprising: a substrate modified with an epoxy group; a polymer attached to the substrate via the epoxy group, wherein at least one structural unit of the polymer comprises an amino group, and the amino group is a primary amino group and/or a secondary amino group; and a probe attached to the polymer, wherein the probe is attached to the polymer via a linker compound, and the linker compound has a molecular structure comprising a first linker compound and a second linker compound; the first linker compound is bonded to the probe, and the second linker compound is attached to the polymer through the amino group, wherein the second linker compound is selected from at least one of an -NHS group, an epoxy group and an isocyanate group, wherein the second linker compound is made of NHS-PEG n -DBCO or NHS-PEG n -N 3 , wherein n is 3 to 2000, and group -NHS in NHS-PEG n -DBCO or NHS-PEG n -N 3 is attached to the amino group via reaction. a substrate modified with an epoxy group; a polymer attached to the substrate via the epoxy group, wherein at least one structural unit of the polymer comprises an amino group, and the amino group is a primary amino group and/or a secondary amino group; and a probe attached to the polymer, wherein the probe is attached to the polymer via a linker compound, and the linker compound has a molecular structure comprising a first linker compound and a second linker compound; the first linker compound is bonded to the probe, and the second linker compound is attached to the polymer through the amino group, wherein the second linker compound is selected from at least one of an -NHS group, an epoxy group and an isocyanate group, wherein the second linker compound is made of NHS-PEG n -DBCO or NHS-PEG n -N 3 , wherein n is 3 to 2000, and group -NHS in NHS-PEG n -DBCO or NHS-PEG n -N 3 is attached to the amino group via reaction.
A process for preparing 2-methoxymethyl-p-phenylenediamine (I), a cosmetically acceptable salt thereof, or mixture thereof, the process comprising the steps of (a) providing 2-methoxymethyl-1,4-benzoquinone (IV); (b) condensing 2-methoxymethyl-1,4-benzoquinone (IV) with an amine source NH2R1 to form 2-(methoxymethyl)-N1(Rl),N4(R1)-cyclohexa-2,5-diene-1,4-diimine (Va); and (c) reacting 2-(methoxymethyl)-N1(Rl),N4(R1)-cyclohexa-2,5-diene-1,4-diimine (Va) in the presence of a hydrogen source to form 2-methoxymethyl-p-phenylenediamine ( I ). (a) providing 2-methoxymethyl-1,4-benzoquinone (IV); (b) condensing 2-methoxymethyl-1,4-benzoquinone (IV) with an amine source NH2R1 to form 2-(methoxymethyl)-N1(Rl),N4(R1)-cyclohexa-2,5-diene-1,4-diimine (Va); and (c) reacting 2-(methoxymethyl)-N1(Rl),N4(R1)-cyclohexa-2,5-diene-1,4-diimine (Va) in the presence of a hydrogen source to form 2-methoxymethyl-p-phenylenediamine ( I ).
A protein conjugate, in which a physiologically active polypeptide is covalently linked to an immunoglobulin Fc variant via a polyethylene glycol, wherein the immunoglobulin Fc variant has an amino acid sequence represented by SEQ ID NO: 80; wherein the physiologically active polypeptide is selected from the group consisting of insulin, glucagon, glucagon like peptide-1 and exendin-4; wherein the immunoglobulin Fc variant shows low FcRn-binding affinity at pH 7.4, but high FcRn-binding affinity at pH 6.0, as compared to the wild-type immunoglobulin Fc fragment; and wherein the wild-type immunoglobulin Fc fragment is a human aglycosylated IgG4 Fc fragment. wherein the immunoglobulin Fc variant has an amino acid sequence represented by SEQ ID NO: 80; wherein the physiologically active polypeptide is selected from the group consisting of insulin, glucagon, glucagon like peptide-1 and exendin-4; wherein the immunoglobulin Fc variant shows low FcRn-binding affinity at pH 7.4, but high FcRn-binding affinity at pH 6.0, as compared to the wild-type immunoglobulin Fc fragment; and
A service path establishment method, wherein the method comprises: receiving (S1101), by a network controller, a service path request message of a first label switched path, LSP, wherein the first LSP has a service association attribute, the service association attribute of the first LSP indicates that the first LSP comprises at least two second LSPs, and the first LSP and the at least two second LSPs have a same first node and last node; computing (S1102), by the network controller, routing information of the second LSPs; and sending (S1103), by the network controller, the routing information of the second LSPs to a first node, so that the first node establishes the first LSP according to the routing information of the second LSPs. receiving (S1101), by a network controller, a service path request message of a first label switched path, LSP, wherein the first LSP has a service association attribute, the service association attribute of the first LSP indicates that the first LSP comprises at least two second LSPs, and the first LSP and the at least two second LSPs have a same first node and last node; computing (S1102), by the network controller, routing information of the second LSPs; and sending (S1103), by the network controller, the routing information of the second LSPs to a first node, so that the first node establishes the first LSP according to the routing information of the second LSPs.
A method for enabling a terminal access to a cell, comprising: when performing a Circuit Switched Domain Fallback, CSFB, service, sending (S101), by a terminal, a location update request to a base station of a first cell; when the terminal receives (S102), a location update reject message, which is returned by the base station of the first cell in response to the location update request, and the terminal determines that a reason for reject is Location Area Not Allowed according to the location update reject message, putting (S103) a Location Area Identification, LAI, of the first cell into a forbidden location areas, LAs, for roaming list; and in response to putting the LAI of the first cell into the forbidden LAs for roaming list, searching (S104), by the terminal, one or more second cells except the first cell, and performing an access operation. when performing a Circuit Switched Domain Fallback, CSFB, service, sending (S101), by a terminal, a location update request to a base station of a first cell; when the terminal receives (S102), a location update reject message, which is returned by the base station of the first cell in response to the location update request, and the terminal determines that a reason for reject is Location Area Not Allowed according to the location update reject message, putting (S103) a Location Area Identification, LAI, of the first cell into a forbidden location areas, LAs, for roaming list; and in response to putting the LAI of the first cell into the forbidden LAs for roaming list, searching (S104), by the terminal, one or more second cells except the first cell, and performing an access operation.
An apparatus for the coating of workpieces, in particularly of turbine blades, with at least one loading chamber and at least one process zone, wherein the apparatus comprises at least one manipulator with a holder on which one or several workpieces can be mounted, wherein the holder can at least partially be moved, wherein the manipulator is slidable in the direction of its longitudinal axis, and wherein the holder is movable in the direction of the longitudinal axis of the manipulator from the loading chamber into the process zone, wherein the manipulator comprises a shaft which can be inserted into the loading chamber and is suitable to set the holder and/or workpieces being placed on the holder in motion, characterized in that the loading chamber comprises a feed-through which is arranged on the side of the loading chamber being the far side with respect to the process zone, and wherein the feed-through comprises at least two telescopic segments which are slidable into each other and the shaft passes through the telescopic segments, wherein a first telescopic segment has a smaller diameter than a second telescopic segment , wherein in an intermediate zone between a section of the outer circumference of the first telescopic segment and a section of the inner circumference of the second telescopic segment at least one sealing in the form of one or several sealing rings is arranged.
A system for controlling an instrument having an elongate body comprising an articulating segment , the system comprising: a user input device configured to provide a control signal to change a shape of the articulating segment in response to input received at the user input device; an optical shape sensor extending in a spiral configuration along a length of and around the articulating segment of the elongate body , the optical shape sensor extending in an integral number of spiral turns, a proximal end and a distal end of the optical shape sensor being aligned along an axial direction of the elongate body ; and a controller in communication with the user input device and the optical shape sensor , wherein the controller is configured to direct movement of the articulating segment in response to the control signal and a signal from the optical shape sensor . a user input device configured to provide a control signal to change a shape of the articulating segment in response to input received at the user input device; an optical shape sensor extending in a spiral configuration along a length of and around the articulating segment of the elongate body , the optical shape sensor extending in an integral number of spiral turns, a proximal end and a distal end of the optical shape sensor being aligned along an axial direction of the elongate body ; and a controller in communication with the user input device and the optical shape sensor , wherein the controller is configured to direct movement of the articulating segment in response to the control signal and a signal from the optical shape sensor .
A method for producing a heterologous protein comprising: culturing a coryneform bacterium having a genetic construct for secretory expression of the heterologous protein; and collecting the heterologous protein produced by secretory production, wherein the coryneform bacterium has been modified so as to harbor a phoS gene encoding a mutant PhoS protein, wherein the mutant PhoS protein is a PhoS protein having a mutation of replacing an amino acid residue corresponding to the tryptophan residue at position 302 in SEQ ID NO: 4 with a lysine residue, alanine residue, valine residue, serine residue, cysteine residue, methionine residue, aspartic acid residue, or asparagine residue in a wild-type PhoS protein, wherein the genetic construct comprises, in the direction from 5' to 3', a promoter sequence that functions in the coryneform bacterium, a nucleic acid sequence encoding a signal peptide that functions in the coryneform bacterium, and a nucleic acid sequence encoding the heterologous protein, and wherein the heterologous protein is expressed as a fusion protein with the signal peptide. culturing a coryneform bacterium having a genetic construct for secretory expression of the heterologous protein; and collecting the heterologous protein produced by secretory production, wherein the coryneform bacterium has been modified so as to harbor a phoS gene encoding a mutant PhoS protein, wherein the mutant PhoS protein is a PhoS protein having a mutation of replacing an amino acid residue corresponding to the tryptophan residue at position 302 in SEQ ID NO: 4 with a lysine residue, alanine residue, valine residue, serine residue, cysteine residue, methionine residue, aspartic acid residue, or asparagine residue in a wild-type PhoS protein, wherein the genetic construct comprises, in the direction from 5' to 3', a promoter sequence that functions in the coryneform bacterium, a nucleic acid sequence encoding a signal peptide that functions in the coryneform bacterium, and a nucleic acid sequence encoding the heterologous protein, and wherein the heterologous protein is expressed as a fusion protein with the signal peptide.
Method for the mechanochemical activation of a clay mixture, characterized by grinding the clay mixture in a mill at a temperature which is in a temperature range of at least 300 degrees Celsius and up to 1000 degrees Celsius.
Light unit for use in an illumination apparatus (2; 2a, 2b) for a motor vehicle (K), having at least one light module having a two-dimensional light body embodied in the form of a light guide and at least one light-emitting means , whose light beams (L) are able to be coupled or are coupled into a side face of the light body , wherein the light beams (L) can exit or do exit to the outside via a light exit face that is surrounded by side faces (31-34) of the light body and wherein at least a part of the side faces (31-34) and a rear-side face located opposite the light exit face are covered by a reflective or diffusely back-scattering covering , wherein the covering of the one light body is formed by a frame-type component having a rear wall and an opening opposite the rear wall , wherein the dimensions of the light body are such that it substantially fills the frame-type component in its mounted position, characterized in that a side wall of the frame-type component has an opening through which the light body is brought laterally into the frame-type component , wherein the at least one light-emitting means is arranged at the side wall of the frame-type component exhibiting the opening , wherein the light body has a transmittance in a range from approximately 85% to approximately 95% and wherein the light unit is formed from a plurality of light modules in which the frame-type components and also the two-dimensional light bodies are in each case connected to one another to form one piece and wherein the frame-type components are attached to a common printed circuit board carrying the light-emitting means that are assigned to the two-dimensional light bodies .
A defect gauge instrument for evaluating a surgical site, comprising: a housing extending along a longitudinal axis (A) between proximal and distal end portions , the housing defining a first channel extending at least partially between the proximal and distal end portions; an angle indicator (AI) aligned with an angular ruler; and an angle leg at least partially received in the first channel such that relative movement between the angle leg and the housing causes relative movement between the angle indicator (AI) and the angular ruler, characterized in that the housing defines a passageway extending along the longitudinal axis (A) between the proximal and distal end portions, and the passageway is dimensioned to slidably receive a guide pin (GP). a housing extending along a longitudinal axis (A) between proximal and distal end portions , the housing defining a first channel extending at least partially between the proximal and distal end portions; an angle indicator (AI) aligned with an angular ruler; and an angle leg at least partially received in the first channel such that relative movement between the angle leg and the housing causes relative movement between the angle indicator (AI) and the angular ruler, characterized in that the housing defines a passageway extending along the longitudinal axis (A) between the proximal and distal end portions, and the passageway is dimensioned to slidably receive a guide pin (GP).
Electrical traction drive for a vehicle, having at least two individual wheel drives which can be controlled independently of each other, characterised by two individually driven wheels on an axle and a common energy source for the two individually driven wheels on the axle , wherein in order to produce an emergency operation function the drives can be operated redundantly, wherein the two individual wheel drives each have an individual control and/or power networking in the manner of a subsystem and wherein each subsystem comprises a separate data bus interface on a central axle drive control device for controlling the individual wheel drives .
Pump arrangement at least comprising a pump having a pressure side and an intake side and a drive unit for the pump which are arranged in a common housing , wherein the drive unit is an axial flow electric drive which comprises a stator which is connected to the housing in a rotationally secure manner and a rotor which is arranged so as to be able to be rotated with respect to the housing , wherein the rotor is arranged with a first end face opposite the stator in an axial direction and forms an outer conveying means of the pump and has on an inner circumferential face a first conveying profile , wherein in a radial direction inside the rotor there is arranged an inner conveying means of the pump which has on an outer circumferential face a second conveying profile which cooperates with the first conveying profile in order to convey a fluid ; characterized in that the inner conveying means is supported on a centering element which is connected to the housing in a rotationally secure manner; wherein at least the rotor and the outer conveying means are configured to be supported exclusively via the fluid conveyed by the pump ; wherein at least between the first end face and the stator a first fluid guiding structure is arranged and connected to the pressure side so that during operation of the electric drive a gap between the first end face and the stator can be produced by the fluid .
A valve unit such as a line blind valve in particular for use in a grease lubrication installation which valve unit may be mounted between a grease container and a pump and where the valve unit comprises: - an inlet section comprising a through-going passage and mounting means for the grease container ; and - an outlet section comprising mounting means to be connected or mounted to the pump, - the valve unit comprises a slide comprising an opening which slide and thereby opening can be displaced relative to the passage of the inlet section and the outlet section thereby closing or opening for passage of the grease, respectively, characterized in that magnets are embedded in the inlet section and in the outlet section which magnets abut the inlet side and outlet side of the slide . - an inlet section comprising a through-going passage and mounting means for the grease container ; and - an outlet section comprising mounting means to be connected or mounted to the pump, - the valve unit comprises a slide comprising an opening which slide and thereby opening can be displaced relative to the passage of the inlet section and the outlet section thereby closing or opening for passage of the grease, respectively, characterized in that magnets are embedded in the inlet section and in the outlet section which magnets abut the inlet side and outlet side of the slide .
Transport system for a nacelle of a wind turbine, wherein the nacelle comprises a generator frame (GT) and a machine frame (MT) and/or a nacelle cover , and the transport system comprises at least two transport units , which are not connected to one another but in each case form a unit in their own right, wherein a rear transport unit is connectable to the generator frame (GT), and a front transport unit is connectable to the machine frame (MT), characterized in that the rear transport unit comprises a rear hollow profile with two identical but laterally inverted rear supporting units which are arranged in a fixed but detachable manner on the hollow profile and which are connectable to the generator frame (GT), and the front transport unit comprises a front hollow profile with two identical but laterally inverted front supporting units which are arranged in a fixed but detachable manner on the hollow profile and which are connectable to the machine frame (MT).
Transdermal therapeutic system for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent-containing layer structure comprising: A) a backing layer; B) an active agent-containing layer comprising at least one silicone-containing polymer; and C) a skin contact layer; wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive, which is directly attached to the active agent-containing layer, wherein the active agent is rivastigmine or buprenorphine. A) a backing layer; B) an active agent-containing layer comprising at least one silicone-containing polymer; and C) a skin contact layer; wherein the skin contact layer is an adhesive layer comprising a silicone gel adhesive, which is directly attached to the active agent-containing layer, wherein the active agent is rivastigmine or buprenorphine.
Method for an automatic selection of a quality of service queuing mechanism for upstream traffic on a high bandwidth access line, comprising: measuring an upstream rate and depending on the upstream rate , keeping a software queuing mechanism enabled in case of the upstream rate below a threshold and using a hardware queuing mechanism in case of the upstream rate above the threshold.