mhurhangee/patent-ind-claim-en huggingface dataset:
A process for the preparation of one or more intermediate chemical compounds useful in the preparation of non-ionic contrast agents wherein the process is carried out continuously using one or more flow procedures, and wherein the process comprises a multi-step chemical synthesis comprising two or more sequential chemical reactions, each reaction leading to the production of an intermediate chemical compound useful in the preparation of non-ionic contrast agents, the two or more sequential reactions being carried out in one or more continuous flow reactors wherein at least two of the two or more sequential reactions are carried out consecutively without interruption, wherein the two or more sequential chemical reactions are selected from either set (i) or set (ii) of the following series of sequential chemical reactions: (i) amidation, reduction of a nitro group via hydrogenation, iodination, acylation and selective hydrolysis; wherein the non-ionic contrast agent is iohexol or iodixanol, and said intermediate chemical compounds useful in the preparation of the non-ionic contrast agents are one or more of the compounds of formula II, III, IV, V and VI: or, (ii) reduction of a nitro group via hydrogenation, iodination, nucleophilic acyl substitution and acylation, and amidation; wherein the non-ionic contrast agent is iopamidol, and said intermediate chemical compounds useful in the preparation of the non-ionic contrast agent are one or more of the compounds of formula VIII, IX, X, XI and XII: (i) amidation, reduction of a nitro group via hydrogenation, iodination, acylation and selective hydrolysis; wherein the non-ionic contrast agent is iohexol or iodixanol, and said intermediate chemical compounds useful in the preparation of the non-ionic contrast agents are one or more of the compounds of formula II, III, IV, V and VI: or, (ii) reduction of a nitro group via hydrogenation, iodination, nucleophilic acyl substitution and acylation, and amidation; wherein the non-ionic contrast agent is iopamidol, and said intermediate chemical compounds useful in the preparation of the non-ionic contrast agent are one or more of the compounds of formula VIII, IX, X, XI and XII:
A rubber composition comprising a rubber component and a short fibrous resin having a ratio A/B of 1.5 or larger, wherein A is a length of a cross section perpendicular to a long axis direction in a long diameter direction thereof and B is a length of the cross section perpendicular to the long axis direction in a short diameter direction thereof, wherein the short fibrous resin is a complex resin comprising a hydrophilic resin and a coat layer coating the hydrophilic resin, wherein the coat layer is composed of a resin having an affinity with the rubber component, wherein the resin having an affinity with the rubber component is a low-melting point resin having a melting point lower than a maximum vulcanization temperature of the rubber composition, and the low-melting point resin is a polyolefin-based resin, and wherein A and B are measured according to the method as disclosed in the present description. a rubber component and a short fibrous resin having a ratio A/B of 1.5 or larger, wherein A is a length of a cross section perpendicular to a long axis direction in a long diameter direction thereof and B is a length of the cross section perpendicular to the long axis direction in a short diameter direction thereof, wherein the short fibrous resin is a complex resin comprising a hydrophilic resin and a coat layer coating the hydrophilic resin, wherein the coat layer is composed of a resin having an affinity with the rubber component, wherein the resin having an affinity with the rubber component is a low-melting point resin having a melting point lower than a maximum vulcanization temperature of the rubber composition, and the low-melting point resin is a polyolefin-based resin, and wherein A and B are measured according to the method as disclosed in the present description.
A method implemented by a device, the method comprising: determining , by the device, a direction of a first signal received from a first signal source; determining , by the device, an intended direction of a second signal in accordance with the direction of the first signal source, with a first beamforming gain of a transmission of the second signal oriented in accordance with the direction of the first signal source being smaller than a second beamforming gain of the transmission of the second signal oriented in accordance with at least a portion of the intended direction; beamforming , by the device, the second signal in accordance with the first and second beamforming gains; and transmitting , by the device, the beamformed second signal; wherein the intended direction comprising multiple directions including a direction that is opposite to the direction of the first signal source, and wherein multiple beams are used to beamform the second signal, and the beamforming gain in the intended direction is highest in the direction that is opposite to the direction of the first signal source. determining , by the device, a direction of a first signal received from a first signal source; determining , by the device, an intended direction of a second signal in accordance with the direction of the first signal source, with a first beamforming gain of a transmission of the second signal oriented in accordance with the direction of the first signal source being smaller than a second beamforming gain of the transmission of the second signal oriented in accordance with at least a portion of the intended direction; beamforming , by the device, the second signal in accordance with the first and second beamforming gains; and transmitting , by the device, the beamformed second signal; wherein the intended direction comprising multiple directions including a direction that is opposite to the direction of the first signal source, and wherein multiple beams are used to beamform the second signal, and the beamforming gain in the intended direction is highest in the direction that is opposite to the direction of the first signal source.
A method of determining sensitivity to cancer treatment in a patient suffering from hepatocellular carcinoma, the method comprising the steps of: determining the presence of overexpression of MYC in a biological sample from the patient, wherein the presence of overexpression of MYC indicates a sensitivity to a treatment by a CDK9 inhibitor.
A transmission device comprising: a generation unit configured to perform error correction encoding and generate, for each layer of a plurality of layers that are subjected to non-orthogonal multiplexing using a codebook, a codeword of a layer of the plurality of layers from data of the layer on the basis of a codebook prepared for said layer, wherein codebooks are prepared for each layer for the purpose of layer separation; and an adjustment unit configured to exchange radio resources between at least two signal elements of one multiplexed codeword, wherein each multiplexed codeword comprises at least two signal elements, wherein the at least two signal elements included in a multiplexed codeword are each mapped to a respective radio resource, wherein the radio resources are to be used in transmission of the at least two signal elements that are included in each of the one or more multiplexed codewords, wherein each of the one or more multiplexed codewords is obtained by multiplexing of codewords of the plurality of layers, and wherein the adjustment unit is configured to dynamically perform the exchange in accordance with degradation of a channel characteristic to suppress deterioration of communication quality and to exchange radio resources, onto which signal elements of different layers are mapped and which require interference cancellation by a reception device, with radio resources, onto which a signal element of a single layer is mapped and which do not require interference cancellation by the reception device. a generation unit configured to perform error correction encoding and generate, for each layer of a plurality of layers that are subjected to non-orthogonal multiplexing using a codebook, a codeword of a layer of the plurality of layers from data of the layer on the basis of a codebook prepared for said layer, wherein codebooks are prepared for each layer for the purpose of layer separation; and an adjustment unit configured to exchange radio resources between at least two signal elements of one multiplexed codeword, wherein each multiplexed codeword comprises at least two signal elements, wherein the at least two signal elements included in a multiplexed codeword are each mapped to a respective radio resource, wherein the radio resources are to be used in transmission of the at least two signal elements that are included in each of the one or more multiplexed codewords, wherein each of the one or more multiplexed codewords is obtained by multiplexing of codewords of the plurality of layers, and wherein the adjustment unit is configured to dynamically perform the exchange in accordance with degradation of a channel characteristic to suppress deterioration of communication quality and to exchange radio resources, onto which signal elements of different layers are mapped and which require interference cancellation by a reception device, with radio resources, onto which a signal element of a single layer is mapped and which do not require interference cancellation by the reception device.
A method for predicting maintenance/replacement period for a component of a vehicle, the vehicle comprising a power-assisted steering system including a steering actuator configured to assist in steering the vehicle at least as compensation for angular deviations of the road wheels caused by road disturbances, the method characterized by : - acquiring (S1) over time steering output data indicative of a magnitude and/or frequency of assisted steering as compensation for angular deviations of the road wheels caused by road disturbances, - comparing (S2) the acquired steering output data with stored component wear data, the stored component wear data being indicative of when maintenance/replacement of the component is due based on wear caused by road disturbances, and - determining (S3), based on the comparison of the acquired steering output data and the stored component wear data, whether or not maintenance/replacement of the component is due. - acquiring (S1) over time steering output data indicative of a magnitude and/or frequency of assisted steering as compensation for angular deviations of the road wheels caused by road disturbances, - comparing (S2) the acquired steering output data with stored component wear data, the stored component wear data being indicative of when maintenance/replacement of the component is due based on wear caused by road disturbances, and - determining (S3), based on the comparison of the acquired steering output data and the stored component wear data, whether or not maintenance/replacement of the component is due.
A method of configuring a notification mode, the method comprising: determining, at a compute device, a physiological state of a person; and configuring a quiet mode of the compute device based on the physiological state of the person, characterised in that configuring the quiet mode of the compute device comprises: determining a distance from the person to the compute device; configuring an audio volume of the compute device as a function of the distance; and configuring an application executing on the compute device to selectively use an audible notification when the compute device is in the quiet mode. determining, at a compute device, a physiological state of a person; and configuring a quiet mode of the compute device based on the physiological state of the person, characterised in that configuring the quiet mode of the compute device comprises: determining a distance from the person to the compute device; configuring an audio volume of the compute device as a function of the distance; and configuring an application executing on the compute device to selectively use an audible notification when the compute device is in the quiet mode. determining a distance from the person to the compute device; configuring an audio volume of the compute device as a function of the distance; and configuring an application executing on the compute device to selectively use an audible notification when the compute device is in the quiet mode.
A composition comprising an expression vector comprising an expression cassette comprising a promoter, wherein the promoter is a fragment of the integrin αIIb gene (ITGA2B) promoter; and an exogenous gene of interest operably linked to said expression cassette, wherein said expression vector further comprises a targeting factor that targets expression of said gene of interest to a specific location with a cell, wherein said targeting factor targets expression of said gene of interest within a specific hematopoietic cell lineage producing platelets, wherein said targeting factor is a fragment of the human Von Willebrand Factor propeptide (VWFpp) operably linked to a D2 domain, and wherein said expression cassette has a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 22 and 23.
A method for determining the rate of progression of Parkinson's disease in a human patient, comprising the steps of: in a sample that has been obtained from said human patient; determining the level of expression of a miRNA according to SEQ ID NO: 1 within said sample; and correlating the level of expression of the determined miRNA to determine the rate of progression of Parkinson's disease in the patient. in a sample that has been obtained from said human patient; determining the level of expression of a miRNA according to SEQ ID NO: 1 within said sample; and correlating the level of expression of the determined miRNA to determine the rate of progression of Parkinson's disease in the patient.
Estriol for use in a method of treating multiple sclerosis in a premenopausal or perimenopausal female subject, wherein the method comprises administering orally to a female subject in need thereof, on a continuous basis for a treatment period of 84 consecutive days (12 weeks), 8 mg of estriol daily; administering orally to the subject, for 14 consecutive days (2 weeks) of the treatment period, 0.7 mg of norethindrone daily; and subcutaneously administering 20 mg of glatiramer acetate per day to the subject on a continuous basis for the treatment period. administering orally to the subject, for 14 consecutive days (2 weeks) of the treatment period, 0.7 mg of norethindrone daily; and subcutaneously administering 20 mg of glatiramer acetate per day to the subject on a continuous basis for the treatment period.
Aqueous composition comprising at least urea, characterized in that it comprises at least one C 20 -C 36 paraffin dispersed in the aqueous phase, the said paraffin representing at least 90% by weight, with respect to the total weight of paraffins in the composition, and from 50 to 10,000 ppm by weight, with respect to the weight of the urea.
Composite based on at least one reinforcing element comprising a metallic surface and on a rubber composition based on at least one diene elastomer, a reinforcing filler, a crosslinking system and fibres having a length of between 1 and 20 mm and a diameter of between 10 μm and 100 μm.
Motor vehicle door latch, comprising a latch case; at least one locking mechanism mounted in the latch case and consisting substantially of a catch and pawl; a latch housing connected to the latch case; the latch case describing a locking mechanism plane and a front panel plane which is different therefrom; the front panel plane being equipped with at least one bridge part spanning an inlet opening and with two lateral parts which border the inlet opening; the latch case being without a bridge part and being equipped with only the two lateral parts; the latch housing completely or partly defining the bridge part; characterized in that the latch case is largely L-shaped in cross section; and the latch housing is permanently connected to the two lateral parts.
Method for evaluating the ability of a chemical substance (S) or of a chemical composition (C) to prevent muscle fatigue and muscle damage induced by physical exertion in humans, said method being characterised in that it comprises: - a step a) of culturing human primary skeletal muscle cells; - a step b) of differentiating the cells obtained in step a) in order to obtain myotubes; - a step c) of bringing a chemical substance (S) or a chemical composition (C) into contact with the cell medium obtained in step b) ; - a step d) of bringing at least one calcium ionophore agent (Al) into contact with the cell medium obtained in step c); - a step e) of measuring the level of expression of a combination of biological markers comprising or consisting of: - at least one biological marker (M 1 ) of glycaemic homeostasis, chosen from the elements of the group consisting of the myokines or cytokines produced by muscles, - at least one biological marker (M 2 ) of muscle lesions, chosen from creatine kinase and lactate dehydrogenase, - at least one biological marker (M 3 ) of ATP metabolism, chosen from the elements of the group consisting of lactate, aqueous ammonia and oxypurines, in the culture medium obtained in step d); and - a step f) of comparing the levels of expression of each of said three biological markers (M 1 ), (M 2 ) and (M 3 ) measured in step e) with the reference expression level for each of these three biological markers. - a step a) of culturing human primary skeletal muscle cells; - a step b) of differentiating the cells obtained in step a) in order to obtain myotubes; - a step c) of bringing a chemical substance (S) or a chemical composition (C) into contact with the cell medium obtained in step b) ; - a step d) of bringing at least one calcium ionophore agent (Al) into contact with the cell medium obtained in step c); - a step e) of measuring the level of expression of a combination of biological markers comprising or consisting of: - at least one biological marker (M 1 ) of glycaemic homeostasis, chosen from the elements of the group consisting of the myokines or cytokines produced by muscles, - at least one biological marker (M 2 ) of muscle lesions, chosen from creatine kinase and lactate dehydrogenase, - at least one biological marker (M 3 ) of ATP metabolism, chosen from the elements of the group consisting of lactate, aqueous ammonia and oxypurines, in the culture medium obtained in step d); and - a step f) of comparing the levels of expression of each of said three biological markers (M 1 ), (M 2 ) and (M 3 ) measured in step e) with the reference expression level for each of these three biological markers.
Pump housing arrangement for a dispenser pump , comprising a chamber for receiving a fluid to be dispensed inside an inside volume of the chamber , an inlet channel for sucking in the fluid into the chamber , an outlet channel for dispensing the fluid out of the chamber and a movable piston bordering an axial side of the chamber , wherein the chamber comprises a flexible wall part adapted to be expanded outwards with respect to the inside volume of the chamber at an increasing inside pressure of the chamber , characterized in that a blocking element relative moveable with respect to the chamber between a blocking position and an operating position is provided, wherein the blocking element blocks an expansion of the wall part in the blocking position and enables the expansion of the wall part in the operating position. a chamber for receiving a fluid to be dispensed inside an inside volume of the chamber , an inlet channel for sucking in the fluid into the chamber , an outlet channel for dispensing the fluid out of the chamber and a movable piston bordering an axial side of the chamber , wherein the chamber comprises a flexible wall part adapted to be expanded outwards with respect to the inside volume of the chamber at an increasing inside pressure of the chamber , characterized in that a blocking element relative moveable with respect to the chamber between a blocking position and an operating position is provided, wherein the blocking element blocks an expansion of the wall part in the blocking position and enables the expansion of the wall part in the operating position.
An ear tip for an earpiece , comprising: a body having first and second ends, an inner wall extending between the first and second ends to define a hollow passage to conduct acoustic energy, and a deformable outer wall connected to the inner wall of the body at the first end and tapering away from the inner wall toward the second end; first and second electrically conductive elements arranged on an outer surface of the deformable outer wall, wherein the inner wall further comprises first (130;140) and second (132;142) conductive leads configured to electrically connect with the first and second electrically conductive elements when the outer wall is deformed toward the inner wall, characterised in that the first and second electrically conductive elements are made in silver/ silver-chloride and arranged in holes punched in the deformable outer wall , said first and second electrically conductive elements being configured as physiological electrodes. a body having first and second ends, an inner wall extending between the first and second ends to define a hollow passage to conduct acoustic energy, and a deformable outer wall connected to the inner wall of the body at the first end and tapering away from the inner wall toward the second end; first and second electrically conductive elements arranged on an outer surface of the deformable outer wall, wherein the inner wall further comprises first (130;140) and second (132;142) conductive leads configured to electrically connect with the first and second electrically conductive elements when the outer wall is deformed toward the inner wall, characterised in that the first and second electrically conductive elements are made in silver/ silver-chloride and arranged in holes punched in the deformable outer wall , said first and second electrically conductive elements being configured as physiological electrodes.
A data processing method, characterized by comprising: receiving , by an access and mobility management function entity, N2 interface information from a policy control function entity for vehicle-to-everything, V2X, communication, wherein the N2 interface information comprises indication information and a quality of service, QoS, parameter used for ProSe communication 5, PC5, interface communication of a terminal device, wherein the indication information is a message type of the N2 interface information; storing , by the access and mobility management function entity based on the indication information, the N2 interface information; and when a preset condition is satisfied, sending , by the access and mobility management function entity, the N2 interface information to a first access network device. receiving , by an access and mobility management function entity, N2 interface information from a policy control function entity for vehicle-to-everything, V2X, communication, wherein the N2 interface information comprises indication information and a quality of service, QoS, parameter used for ProSe communication 5, PC5, interface communication of a terminal device, wherein the indication information is a message type of the N2 interface information; storing , by the access and mobility management function entity based on the indication information, the N2 interface information; and when a preset condition is satisfied, sending , by the access and mobility management function entity, the N2 interface information to a first access network device.