mhurhangee/patent-ind-claim-en huggingface dataset:
A method for predicting response of a patient with a malignant disease to immunotherapy, wherein said malignant disease is a cancer disease, wherein a DNA methylation analysis of at least one immunoregulatory gene of cells of the malignant disease and/or of T lymphocytes interacting with said cells of the malignant disease is performed, wherein said immunoregulatory gene encodes an immune checkpoint selected from B7 proteins and their receptors and selected from the group consisting of the B7 proteins and their receptor encoding genes CD274, PDCD1LG2 and PDCD1, the B7 protein and its receptor encoding genes CD80 and CTLA4, the gene ICOS encoding the receptor of a B7 protein and the B7 proteins encoding genes CD276, C10orf54 and HHLA2, and any combinations thereof, wherein said immunotherapy comprises at least one pharmaceutical compound which is an immune checkpoint inhibitor intended to alter the immunoregulatory effect of said immune checkpoint, and the result of the DNA methylation analysis is compared to a reference value to determine the patient's response to the immunotherapy. wherein said malignant disease is a cancer disease, wherein a DNA methylation analysis of at least one immunoregulatory gene of cells of the malignant disease and/or of T lymphocytes interacting with said cells of the malignant disease is performed, wherein said immunoregulatory gene encodes an immune checkpoint selected from B7 proteins and their receptors and selected from the group consisting of the B7 proteins and their receptor encoding genes CD274, PDCD1LG2 and PDCD1, the B7 protein and its receptor encoding genes CD80 and CTLA4, the gene ICOS encoding the receptor of a B7 protein and the B7 proteins encoding genes CD276, C10orf54 and HHLA2, and any combinations thereof, wherein said immunotherapy comprises at least one pharmaceutical compound which is an immune checkpoint inhibitor intended to alter the immunoregulatory effect of said immune checkpoint, and the result of the DNA methylation analysis is compared to a reference value to determine the patient's response to the immunotherapy.
A photovoltaic (PV) cell comprising: an emitter layer ; a base layer adjacent to said emitter layer ; and a back surface field (BSF) layer adjacent to said base layer , said BSF layer comprising: a first layer comprising a first material, the first layer adjacent to the base layer , wherein the first material of said first layer of said BSF layer comprises AlGaAs material; and a second layer adjacent to said first layer and comprising a second material different than the first material, wherein the second material of said second layer of said BSF layer comprises AlGaInAs material, said second layer of said BSF layer is lattice-matched to said base layer , and said first layer of said BSF layer is lattice-mismatched to said base layer . an emitter layer ; a base layer adjacent to said emitter layer ; and a back surface field (BSF) layer adjacent to said base layer , said BSF layer comprising: a first layer comprising a first material, the first layer adjacent to the base layer , wherein the first material of said first layer of said BSF layer comprises AlGaAs material; and a second layer adjacent to said first layer and comprising a second material different than the first material, wherein the second material of said second layer of said BSF layer comprises AlGaInAs material, said second layer of said BSF layer is lattice-matched to said base layer , and said first layer of said BSF layer is lattice-mismatched to said base layer . a first layer comprising a first material, the first layer adjacent to the base layer , wherein the first material of said first layer of said BSF layer comprises AlGaAs material; and a second layer adjacent to said first layer and comprising a second material different than the first material, wherein the second material of said second layer of said BSF layer comprises AlGaInAs material, said second layer of said BSF layer is lattice-matched to said base layer , and said first layer of said BSF layer is lattice-mismatched to said base layer .
An autonomous cleaning system comprising: an autonomous floor cleaner ; an artificial barrier generator comprising a plurality of infrared transmitters , wherein a first one of the plurality of infrared transmitters is configured to emit a first signal and a second one of the plurality of infrared transmitters is configured to emit a second signal ; characterized in that the cleaning system comprises: a first keep out setting in which the autonomous floor cleaner alters course upon detection of the first signal and does not alter course upon detection of the second signal ; a second keep out setting in which the autonomous floor cleaner alters course upon detection of the second signal and does not alter course upon detection of the first signal ; and a third keep out setting in which the autonomous floor cleaner alters course upon detection of either one of the first signal and the second signal . an autonomous floor cleaner ; an artificial barrier generator comprising a plurality of infrared transmitters , wherein a first one of the plurality of infrared transmitters is configured to emit a first signal and a second one of the plurality of infrared transmitters is configured to emit a second signal ; characterized in that the cleaning system comprises: a first keep out setting in which the autonomous floor cleaner alters course upon detection of the first signal and does not alter course upon detection of the second signal ; a second keep out setting in which the autonomous floor cleaner alters course upon detection of the second signal and does not alter course upon detection of the first signal ; and a third keep out setting in which the autonomous floor cleaner alters course upon detection of either one of the first signal and the second signal . a first keep out setting in which the autonomous floor cleaner alters course upon detection of the first signal and does not alter course upon detection of the second signal ; a second keep out setting in which the autonomous floor cleaner alters course upon detection of the second signal and does not alter course upon detection of the first signal ; and a third keep out setting in which the autonomous floor cleaner alters course upon detection of either one of the first signal and the second signal .
Method for manufacturing a coil for a generator of a wind turbine, which is formed from various conductor strands arranged parallel to one another and beside one another, at least in sections , which are individually deformed and wound into multiple windings to form partial coils , wherein the wound partial coils are deformed individually and separately from one another in such a way that relatively long rectilinear sections provided to rest on one another are formed, and are subsequently assembled to form the coil , wherein the conductor strands are respectively wound in a plane to form the partial coils , in sections of the conductor strands between winding head regions , which connect the aforementioned rectilinear sections of the conductor strands to one another, the partial coils are spread apart in opposite directions at right angles to the plane in which the respective conductor strands have been wound to form the partial coils , and bends formed at ends of the rectilinear sections of the various conductor strands as they are spread apart are shaped so as to be offset relative to one another, in such a way that the respective outer rectilinear sections of the partial coils in the coil are longer than the respective inner rectilinear sections , so that the outer bends and sections enclose the inner bends and sections , wherein the conductor strands , after they have been wound to form the partial coils , are deformed in such a way that, at least in the aforementioned rectilinear sections , they can be arranged to rest directly on one another.
Stream multiplexer , comprising: a reception interface for receiving encoded data for each of at least two different spatial segments or different groups of subsequent spatial segments of a video picture of a video stream encoded thereinto; and a data stream former configured to packetize the encoded data for each of the at least two different spatial segments or different groups of subsequent spatial segments into separate substreams , and to provide the separate substreams at an output; wherein the at least two different spatial segments or different groups of subsequent spatial segments of the video picture of the video stream are encoded such that the encoded data comprises, for each spatial segment or group of spatial segments , at least one slice; wherein the data stream former is configured to packetize slice data of each of the at least one slice of at least one of the spatial segments or groups of subsequent spatial segments into one separate substream ; wherein the data stream former is configured to provide a further separate substream comprising suitable slice headers that, when combined with the slice data, results in a conformant HEVC bitstream, wherein the suitable slice headers contain a parameter set referencing with a new picture size. a reception interface for receiving encoded data for each of at least two different spatial segments or different groups of subsequent spatial segments of a video picture of a video stream encoded thereinto; and a data stream former configured to packetize the encoded data for each of the at least two different spatial segments or different groups of subsequent spatial segments into separate substreams , and to provide the separate substreams at an output; wherein the at least two different spatial segments or different groups of subsequent spatial segments of the video picture of the video stream are encoded such that the encoded data comprises, for each spatial segment or group of spatial segments , at least one slice; wherein the data stream former is configured to packetize slice data of each of the at least one slice of at least one of the spatial segments or groups of subsequent spatial segments into one separate substream ; wherein the data stream former is configured to provide a further separate substream comprising suitable slice headers that, when combined with the slice data, results in a conformant HEVC bitstream, wherein the suitable slice headers contain a parameter set referencing with a new picture size.
A linear actuator assembly comprising: an armature , a first coil , and a second coil ; the armature cooperating with the first coil and with the second coil such that a first electric current through the first coil causes a first magnetic flux urging the armature in a first direction and such that a second electric current through the second coil causes a second magnetic flux urging the armature in a second direction, the second direction being opposite the first direction, the armature , the first coil , and the second coil thereby forming a linear actuator; a current source electrically connected to the first coil for applying the first electric current through the first coil and electrically connected to the second coil for applying the second electric current through the second coil ; the current source comprising a first active component (13a; 14a; 16a), the first active component (13a; 14a; 16a) being electrically connected in series with the first coil ; and the current source comprising a second active component (13b; 14b; 16b), the second active component (13b; 14b; 16b) being different from the first active component (13a; 14a; 16a) and being electrically connected in series with the second coil ; characterised in that the first coil and the second coil are arranged inside the armature . an armature , a first coil , and a second coil ; the armature cooperating with the first coil and with the second coil such that a first electric current through the first coil causes a first magnetic flux urging the armature in a first direction and such that a second electric current through the second coil causes a second magnetic flux urging the armature in a second direction, the second direction being opposite the first direction, the armature , the first coil , and the second coil thereby forming a linear actuator; a current source electrically connected to the first coil for applying the first electric current through the first coil and electrically connected to the second coil for applying the second electric current through the second coil ; the current source comprising a first active component (13a; 14a; 16a), the first active component (13a; 14a; 16a) being electrically connected in series with the first coil ; and the current source comprising a second active component (13b; 14b; 16b), the second active component (13b; 14b; 16b) being different from the first active component (13a; 14a; 16a) and being electrically connected in series with the second coil ; characterised in that the first coil and the second coil are arranged inside the armature .
An organic electroluminescent display panel, comprising a base substrate and a pixel definition layer located on the base substrate , wherein: the pixel definition layer has opening regions corresponding to pixel areas of the organic electroluminescent display panel, and each of the opening regions has an opening larger than a bottom surface of the opening region ; an upper surface (a) of the pixel definition layer is formed from a hydrophobic material, and an inclination surface (b) of the pixel definition layer corresponding to each of the opening regions is formed from a hydrophilic material, characterized in that each of the opening regions has a cross-section perpendicular to the base substrate with a width firstly increased and then decreased in a continuous manner from the opening to the bottom surface. the pixel definition layer has opening regions corresponding to pixel areas of the organic electroluminescent display panel, and each of the opening regions has an opening larger than a bottom surface of the opening region ; an upper surface (a) of the pixel definition layer is formed from a hydrophobic material, and an inclination surface (b) of the pixel definition layer corresponding to each of the opening regions is formed from a hydrophilic material, characterized in that each of the opening regions has a cross-section perpendicular to the base substrate with a width firstly increased and then decreased in a continuous manner from the opening to the bottom surface.
A tokamak comprising: a toroidal containment vessel configured to contain a plasma ; a plasma initiation system comprising upper and lower poloidal field, PF, coil sets, each PF coil set comprising: at least one inner PF (403;502,503) coil located outside the containment vessel; an outer PF coil (401;501) located inside the containment vessel; wherein the inner PF coil is located radially inward of the outer PF coil; and shielding located between the outer PF coil and a location of the plasma during operation of the tokamak and configured to protect the outer PF coil from heat emitted by the plasma; characterised in that the inner and outer PF coils are configured so as to form a PF null within the containment vessel between the inner and outer PF coils, such that the upper and lower PF coil pairs are operable to initiate a plasma in the containment vessel via double null merging. a toroidal containment vessel configured to contain a plasma ; a plasma initiation system comprising upper and lower poloidal field, PF, coil sets, each PF coil set comprising: at least one inner PF (403;502,503) coil located outside the containment vessel; an outer PF coil (401;501) located inside the containment vessel; wherein the inner PF coil is located radially inward of the outer PF coil; and shielding located between the outer PF coil and a location of the plasma during operation of the tokamak and configured to protect the outer PF coil from heat emitted by the plasma; characterised in that the inner and outer PF coils are configured so as to form a PF null within the containment vessel between the inner and outer PF coils, such that the upper and lower PF coil pairs are operable to initiate a plasma in the containment vessel via double null merging. at least one inner PF (403;502,503) coil located outside the containment vessel; an outer PF coil (401;501) located inside the containment vessel; wherein the inner PF coil is located radially inward of the outer PF coil; and shielding located between the outer PF coil and a location of the plasma during operation of the tokamak and configured to protect the outer PF coil from heat emitted by the plasma; characterised in that the inner and outer PF coils are configured so as to form a PF null within the containment vessel between the inner and outer PF coils, such that the upper and lower PF coil pairs are operable to initiate a plasma in the containment vessel via double null merging.
A thermal management system for an aircraft including a propeller arrangement and a battery powering the propeller arrangement, the thermal management system comprising: a refrigeration circuit including a compressor , a condenser arrangement , an expansion valve , and a chiller , the compressor being configured to route a refrigerant past the condenser arrangement and past the expansion valve to the chiller, the condenser arrangement including an air-cooled condenser exposed to ambient temperature air outside the aircraft and a liquid-cooled condenser ; a battery cooling circuit configured to route first coolant past the battery of the aircraft, the battery cooling circuit including a first tank , a first pump , and the chiller, the first pump being configured to direct the first coolant from the first tank, past the battery at which heat is absorbed by the first coolant, to the chiller at which heat is rejected from the first coolant to the refrigerant; and a propeller arrangement cooling circuit configured to cool the propeller arrangement of the aircraft using second coolant drawn from a second tank by a second pump , the propeller arrangement cooling circuit including a radiator arrangement exposed to the ambient temperature air, wherein the propeller arrangement cooling circuit is configured to direct the second coolant drawn from the second tank to the propeller arrangement and/or along a condenser routing path to the liquid-cooled condenser, and the radiator arrangement is disposed downstream of the liquid-cooled condenser. a refrigeration circuit including a compressor , a condenser arrangement , an expansion valve , and a chiller , the compressor being configured to route a refrigerant past the condenser arrangement and past the expansion valve to the chiller, the condenser arrangement including an air-cooled condenser exposed to ambient temperature air outside the aircraft and a liquid-cooled condenser ; a battery cooling circuit configured to route first coolant past the battery of the aircraft, the battery cooling circuit including a first tank , a first pump , and the chiller, the first pump being configured to direct the first coolant from the first tank, past the battery at which heat is absorbed by the first coolant, to the chiller at which heat is rejected from the first coolant to the refrigerant; and a propeller arrangement cooling circuit configured to cool the propeller arrangement of the aircraft using second coolant drawn from a second tank by a second pump , the propeller arrangement cooling circuit including a radiator arrangement exposed to the ambient temperature air, wherein the propeller arrangement cooling circuit is configured to direct the second coolant drawn from the second tank to the propeller arrangement and/or along a condenser routing path to the liquid-cooled condenser, and the radiator arrangement is disposed downstream of the liquid-cooled condenser.
A conjugate comprising an entry inhibitor covalently attached to a water soluble polymer by a degradable linkage, wherein the conjugate corresponds to one of the following structures or wherein: POLY is poly(ethylene glycol) that in formulae II and III is terminally capped with methoxy; L is either -O- or -NH-C(O); P is a spacer; Ar is an ortho, meta, or para -substituted phenyl; Z is -O-, -NH-, or -CH 2 -; -NH- in structure II is an amino residue of EI; -O- in structure III is a hydroxyl residue of EI; k is 1, 2 or 3; y is 3, 4, 5, 6, 7, or 8; EI is an HIV-entry inhibitor that is either T-20 or T-1249; R is a core molecule. POLY is poly(ethylene glycol) that in formulae II and III is terminally capped with methoxy; L is either -O- or -NH-C(O); P is a spacer; Ar is an ortho, meta, or para -substituted phenyl; Z is -O-, -NH-, or -CH 2 -; -NH- in structure II is an amino residue of EI; -O- in structure III is a hydroxyl residue of EI; k is 1, 2 or 3; y is 3, 4, 5, 6, 7, or 8; EI is an HIV-entry inhibitor that is either T-20 or T-1249; R is a core molecule.
A composition comprising a pharmaceutically effective amount of a pharmaceutically acceptable benzoate salt of 5-methoxy-N,N-dimethyltryptamine wherein the SMeODMT benzoate is characterised by peaks in an XRPD diffractogram at 17.5, 17.7 and 21.0°2θ±0.1°2θ as measured using an x-ray wavelength of 1.5406 Å.
A fan coil comprising: - an inlet and an outlet for heat-transfer fluid; - a heat exchanger positioned essentially vertically in use, connected to the heat-transfer fluid inlet and outlet, the largest surface width x height of which corresponds to the front part of the fan coil , said heat exchanger comprising a hot-fluid collector, a cold-fluid collector and a plurality of micro-channels that are located between said collectors and allow the circulation from the hot-fluid collector to the cold-fluid collector, said micro-channels being arranged in rows connected to one another by a set of fins ; - an air duct or plenum supplying ambient air located behind the heat exchanger, forming a cavity arranged so as to ensure an air flow from bottom to top which is as uniform as possible at the outlet of the heat exchanger; - at least one fan located at the base of the fan coil under the plenum supplying ambient air; characterized in that the fan coil comprises a plurality of axial fans distributed at the same height over the entire width of the fan coil, so as to allow the circulation of ambient air in the plenum and next through the heat exchanger toward the outside, through the front part of the fan coil , and in that the plenum supplying ambient air has a cross-section which linearly narrows from its part that is proximal to the fans toward its part that is distal to the fans , as well as a constant width. - an inlet and an outlet for heat-transfer fluid; - a heat exchanger positioned essentially vertically in use, connected to the heat-transfer fluid inlet and outlet, the largest surface width x height of which corresponds to the front part of the fan coil , said heat exchanger comprising a hot-fluid collector, a cold-fluid collector and a plurality of micro-channels that are located between said collectors and allow the circulation from the hot-fluid collector to the cold-fluid collector, said micro-channels being arranged in rows connected to one another by a set of fins ; - an air duct or plenum supplying ambient air located behind the heat exchanger, forming a cavity arranged so as to ensure an air flow from bottom to top which is as uniform as possible at the outlet of the heat exchanger; - at least one fan located at the base of the fan coil under the plenum supplying ambient air;