mhurhangee/patent-ind-claim-en huggingface dataset:
A method of preparing a CTL for treating cancer in a subject comprising: (a) identifying tumor mutations in expressed genes of the subject by a method comprising whole genome or whole exome nucleic acid sequencing of tumor and normal tissue samples from the subject, wherein the mutations are present in the genome of the cancer cells of the subject but not in normal tissue from the subject, wherein when said mutation identified is a: A. point mutation further identifying a mutant peptide having the point mutation; and/or B. splice-site, frame shift, read-through or gene-fusion mutation further identifying a neoepitope generated by the mutation; (b) selecting a mutant peptide or neoepitope identified in step (a) that binds to a HLA protein; and (c) using a mutant peptide or neoepitope selected in (b) to elicit CTL ex vivo. (a) identifying tumor mutations in expressed genes of the subject by a method comprising whole genome or whole exome nucleic acid sequencing of tumor and normal tissue samples from the subject, wherein the mutations are present in the genome of the cancer cells of the subject but not in normal tissue from the subject, wherein when said mutation identified is a: A. point mutation further identifying a mutant peptide having the point mutation; and/or B. splice-site, frame shift, read-through or gene-fusion mutation further identifying a neoepitope generated by the mutation; A. point mutation further identifying a mutant peptide having the point mutation; and/or B. splice-site, frame shift, read-through or gene-fusion mutation further identifying a neoepitope generated by the mutation; (b) selecting a mutant peptide or neoepitope identified in step (a) that binds to a HLA protein; and (c) using a mutant peptide or neoepitope selected in (b) to elicit CTL ex vivo.
A method of assessing a characteristic of a plant, comprising: obtaining (S20) a training dataset, wherein the training dataset comprises first data characterising a first electrical signal obtained from a first plant during a first time period when a stressor is present in the first plant or in a growth environment of the first plant, the first electrical signal indicative of bioelectrical activity within the first plant, second data characterising a second electrical signal obtained from the first plant during a second time period when a stressor is not present in the first plant or in the growth environment of the first plant the second electrical signal indicative of bioelectrical activity within the first plant, and third data indicative of a characteristic of the first plant during the first time period and a characteristic of the first plant during the second time period; training (S21) a machine learning model based upon the training dataset; obtaining (S22) a third electrical signal from a second plant, the third electrical signal indicative of bioelectrical activity within the second plant; and assessing (S23), using the trained machine learning model, a characteristic of the second plant based upon the third electrical signal. obtaining (S20) a training dataset, wherein the training dataset comprises first data characterising a first electrical signal obtained from a first plant during a first time period when a stressor is present in the first plant or in a growth environment of the first plant, the first electrical signal indicative of bioelectrical activity within the first plant, second data characterising a second electrical signal obtained from the first plant during a second time period when a stressor is not present in the first plant or in the growth environment of the first plant the second electrical signal indicative of bioelectrical activity within the first plant, and third data indicative of a characteristic of the first plant during the first time period and a characteristic of the first plant during the second time period; training (S21) a machine learning model based upon the training dataset; obtaining (S22) a third electrical signal from a second plant, the third electrical signal indicative of bioelectrical activity within the second plant; and assessing (S23), using the trained machine learning model, a characteristic of the second plant based upon the third electrical signal.
A pad (1; 11) for disc brakes for railway vehicles comprising a base plate , a plurality of friction elements , which are fixed to the base plate, and a plurality of spacers (8; 12), each mounted between said base plate and a respective friction element ; in each one of said spacers (8; 12) there being obtained at least one fixing hole (8a; 12a), which is engaged by a respective rivet suited to lock the friction element to the base plate ; said pad being characterized in that each one of said spacers (8; 12) consists of a plurality of metal plaques (9; 15), each having a fixing hole (8a; 12a) obtained in it; said metal plaques (9; 15) being stacked on top of one another so that the respective fixing holes (8a; 12a) coincide; each of the metal plaques (9; 15) being between 0.1 and 1 mm thick.
A magnetic field measurement apparatus, comprising: an optically detected magnetic resonance member arranged in a measurement target AC magnetic field; a coil that is configured to apply a magnetic field of a microwave to the optically detected magnetic resonance member ; a high frequency power supply that is configured to cause the coil to conduct a current of the microwave; an irradiating device that is configured to irradiate the optically detected magnetic resonance member with light; a light receiving device that is configured to detect light that the optically detected magnetic resonance member emits; a measurement control unit that is configured to perform a predetermined DC magnetic field measurement Ramsey pulse sequence at a predetermined phase of the measurement target AC magnetic field, and in the DC magnetic field measurement sequence, to control the high frequency power supply and the irradiating device and thereby to determine a detection light intensity of the light detected by the light receiving device ; and a magnetic field calculation unit that is configured to calculate an intensity of the measurement target AC magnetic field on the basis of the predetermined phase and the detection light intensity. an optically detected magnetic resonance member arranged in a measurement target AC magnetic field; a coil that is configured to apply a magnetic field of a microwave to the optically detected magnetic resonance member ; a high frequency power supply that is configured to cause the coil to conduct a current of the microwave; an irradiating device that is configured to irradiate the optically detected magnetic resonance member with light; a light receiving device that is configured to detect light that the optically detected magnetic resonance member emits; a measurement control unit that is configured to perform a predetermined DC magnetic field measurement Ramsey pulse sequence at a predetermined phase of the measurement target AC magnetic field, and in the DC magnetic field measurement sequence, to control the high frequency power supply and the irradiating device and thereby to determine a detection light intensity of the light detected by the light receiving device ; and a magnetic field calculation unit that is configured to calculate an intensity of the measurement target AC magnetic field on the basis of the predetermined phase and the detection light intensity.
A trocar assembly for releasable engagement with an adapter assembly of a surgical stapling instrument , the trocar assembly comprising: a housing including a tubular body and defining a longitudinal axis, the tubular body defining at least one arcuate slot extending circumferentially about a distal portion of the tubular body; an end cap rotatably supported on the distal portion of the tubular body, the end cap including at least one post configured to be received within the arcuate slot of the tubular body to limit rotation of the end cap; and a trocar mechanism supported with the housing and movable between a retracted position and an advanced position, the trocar mechanism including a tubular member and a trocar member pivotally secured to the tubular member, the trocar mechanism and the end cap being rotationally fixed relative to one another such that rotation of the end cap along the longitudinal axis causes rotation of the trocar mechanism along the longitudinal axis. a housing including a tubular body and defining a longitudinal axis, the tubular body defining at least one arcuate slot extending circumferentially about a distal portion of the tubular body; an end cap rotatably supported on the distal portion of the tubular body, the end cap including at least one post configured to be received within the arcuate slot of the tubular body to limit rotation of the end cap; and a trocar mechanism supported with the housing and movable between a retracted position and an advanced position, the trocar mechanism including a tubular member and a trocar member pivotally secured to the tubular member, the trocar mechanism and the end cap being rotationally fixed relative to one another such that rotation of the end cap along the longitudinal axis causes rotation of the trocar mechanism along the longitudinal axis.
A process for producing a particulate cellulose derivative by grinding and drying a moist cellulose derivative or for increasing the flowability and/or the onset dissolution temperature of a particulate cellulose derivative, comprising the steps of A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative, B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill by feeding a lower amount of gas per unit of cellulose derivative to be ground and dried into the gas-swept impact mill than the amount of gas that would be required to dry and grind the cellulose derivative to an essentially dry product in the gas-swept impact mill; and C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill reducing the moisture content to 1 to 5 percent based on the total weight of the moist cellulose derivative, wherein the gas stream used for drying the cellulose derivative is split into two streams via a slide valve wherein the first gas stream is fed into the gas-swept impact mill and the second stream is contacted with the ground and partially dried cellulose derivative that leaves the impact mill such that the cellulose derivative is suspended in the entire amount or in at least a portion of the gas stream exiting the gas swept impact mill when it is contacted with the second gas stream. A) providing a cellulose derivative having a moisture content of from 60 to 95 percent, based on the total weight of the moist cellulose derivative, B) grinding and partially drying the moist cellulose derivative in a gas-swept impact mill by feeding a lower amount of gas per unit of cellulose derivative to be ground and dried into the gas-swept impact mill than the amount of gas that would be required to dry and grind the cellulose derivative to an essentially dry product in the gas-swept impact mill; and C) contacting the ground and partially dried cellulose derivative with an additional amount of a drying gas outside the gas-swept impact mill reducing the moisture content to 1 to 5 percent based on the total weight of the moist cellulose derivative,
A computer-implemented group chat method, performed at a terminal, the method comprising: outputting a selection interface to a user through a group chat interface of the terminal, wherein the selection interface is used for prompting the user to select, in the group chat interface, a group chat message of a to-be-followed group member; acquiring a group member ID of the group chat message selected by the user through the selection interface, wherein the group member ID of the group chat message is a group member ID of a sender of the group chat message; and displaying, in a preset manner different from a default display manner in the group chat interface, group chat messages corresponding to the group member ID in the subsequent group chat. outputting a selection interface to a user through a group chat interface of the terminal, wherein the selection interface is used for prompting the user to select, in the group chat interface, a group chat message of a to-be-followed group member; acquiring a group member ID of the group chat message selected by the user through the selection interface, wherein the group member ID of the group chat message is a group member ID of a sender of the group chat message; and displaying, in a preset manner different from a default display manner in the group chat interface, group chat messages corresponding to the group member ID in the subsequent group chat.
An ACC inhibitor for use in combination with an FXR agonist for treating and/or preventing a liver disease, wherein the ACC inhibitor is a compound of Formula (I): , or a pharmaceutically acceptable salt thereof; and the FXR agonist is a compound of Formula (III): or a pharmaceutically acceptable salt thereof.
An oriented electrical steel sheet comprising Si at 1.0 wt% to 7.0 wt%, C at 0.0050 wt% or less (excluding 0 wt%), Al at 0.005 wt% or less (excluding 0 wt%), N at 0.0055 wt% or less (excluding 0 wt%), S at 0.0055 wt% or less (excluding 0 wt%), and Mn at 0.01 wt% to 0.5 wt%, Ba alone at 0.005 wt% to 0.5 wt%, Y alone at 0.005 wt% to 0.5 wt%, or a composite of Ba and Y at 0.005 wt% to 0.5 wt%, the remainder including Fe and impurities, based on 100 wt% of a total composition of a base steel sheet thereof.
A non-transitory, computer-readable medium comprising instructions that, when executed by processing circuitry , cause the processing circuitry to perform a method, the method comprising: determining evoked compound action potential (ECAP) data indicative of a plurality of ECAPs based on signals sensed from a patient; controlling a user interface to display the ECAP data over a time window; identifying an ECAP amplitude in the ECAP data at a specific time in the time window, wherein the ECAP amplitude exceeds a threshold amplitude; controlling the user interface to display a slidable marker that identifies the ECAP amplitude at the specific time over the displayed ECAP data, wherein the slidable marker is configured to be user-movable to different times within the time window; and controlling the user interface to display an ECAP waveform corresponding to the ECAP amplitude identified by the slidable marker. determining evoked compound action potential (ECAP) data indicative of a plurality of ECAPs based on signals sensed from a patient; controlling a user interface to display the ECAP data over a time window; identifying an ECAP amplitude in the ECAP data at a specific time in the time window, wherein the ECAP amplitude exceeds a threshold amplitude; controlling the user interface to display a slidable marker that identifies the ECAP amplitude at the specific time over the displayed ECAP data, wherein the slidable marker is configured to be user-movable to different times within the time window; and controlling the user interface to display an ECAP waveform corresponding to the ECAP amplitude identified by the slidable marker.
A display device or portable terminal , comprising: a window member comprising a flat portion (FA) and a bent portion (BA1, BA2) connected to the flat portion (FA); a display panel disposed on a rear surface of the window member and comprising a central portion (CP) and a corner portion (CNP) protruding from the central portion (CP) and overlapping with the flat portion (FA) and the bent portion (BA1, BA2); a first sealing member (SM1, SM11) disposed on a rear surface of the display panel and overlapping with the corner portion (CNP); a second sealing member (SM2, SM12) disposed on the rear surface of the window member and spaced apart from the central portion (CP) and the corner portion (CNP); a first adhesive (AD1, AD11) contacting the first sealing member (SM1, SM11) and the second sealing member (SM2, SM12) and sealing a space which is defined between the first sealing member (SM1, SM11) and the second sealing member (SM2, SM12) in the flat portion (FA). a window member comprising a flat portion (FA) and a bent portion (BA1, BA2) connected to the flat portion (FA); a display panel disposed on a rear surface of the window member and comprising a central portion (CP) and a corner portion (CNP) protruding from the central portion (CP) and overlapping with the flat portion (FA) and the bent portion (BA1, BA2); a first sealing member (SM1, SM11) disposed on a rear surface of the display panel and overlapping with the corner portion (CNP); a second sealing member (SM2, SM12) disposed on the rear surface of the window member and spaced apart from the central portion (CP) and the corner portion (CNP); a first adhesive (AD1, AD11) contacting the first sealing member (SM1, SM11) and the second sealing member (SM2, SM12) and sealing a space which is defined between the first sealing member (SM1, SM11) and the second sealing member (SM2, SM12) in the flat portion (FA).
An articulated arm CMM comprising: an articulated arm comprising a plurality of articulated arm members, a measuring probe at a distal end, and a base at a proximal end; and a docking portion on the base, the docking portion configured to form a connection with a modular feature pack, the modular feature pack being arranged to provide additional functionality to the CMM; wherein the docking portion comprises an electronic connector configured to form an electronic connection with the feature pack. an articulated arm comprising a plurality of articulated arm members, a measuring probe at a distal end, and a base at a proximal end; and a docking portion on the base, the docking portion configured to form a connection with a modular feature pack, the modular feature pack being arranged to provide additional functionality to the CMM; wherein the docking portion comprises an electronic connector configured to form an electronic connection with the feature pack.
An apparatus comprising: a processor ; a memory in electronic communication with the processor ; and instructions stored in the memory , the instructions being executable by the processor to: receive a diagnostic response; identify a diagnostic request corresponding to the diagnostic response, based at least in part on a comparison of a first protocol data unit ,PDU, identifier associated with the diagnostic request and a second PDU identifier associated with the diagnostic response; route the diagnostic response to a diagnostic client associated with the diagnostic request, and identify a routing path between a diagnostic target and the diagnostic client based at least in part on the first PDU identifier and the second PDU identifier, wherein the routing path is associated with the diagnostic request, wherein routing the diagnostic response to the diagnostic client comprises transmitting the diagnostic response to the diagnostic client based at least in part on the routing path. a processor ; a memory in electronic communication with the processor ; and instructions stored in the memory , the instructions being executable by the processor to: receive a diagnostic response; identify a diagnostic request corresponding to the diagnostic response, based at least in part on a comparison of a first protocol data unit ,PDU, identifier associated with the diagnostic request and a second PDU identifier associated with the diagnostic response; route the diagnostic response to a diagnostic client associated with the diagnostic request, and identify a routing path between a diagnostic target and the diagnostic client based at least in part on the first PDU identifier and the second PDU identifier, wherein the routing path is associated with the diagnostic request, wherein routing the diagnostic response to the diagnostic client comprises transmitting the diagnostic response to the diagnostic client based at least in part on the routing path. receive a diagnostic response; identify a diagnostic request corresponding to the diagnostic response, based at least in part on a comparison of a first protocol data unit ,PDU, identifier associated with the diagnostic request and a second PDU identifier associated with the diagnostic response; route the diagnostic response to a diagnostic client associated with the diagnostic request, and identify a routing path between a diagnostic target and the diagnostic client based at least in part on the first PDU identifier and the second PDU identifier, wherein the routing path is associated with the diagnostic request, wherein routing the diagnostic response to the diagnostic client comprises transmitting the diagnostic response to the diagnostic client based at least in part on the routing path.
Solenoid consisting of a coil that generates a magnetic field when electric current flows through said coil, a connection region for a current source, at least one current-carrying pin , a pin provided for earthing an electrically conducting casing of the solenoid and a guiding piece , wherein the at least one current-carrying pin and the pin provided for earthing the casing are arranged at the connection region , and the current-carrying pin is in connection with a substantially rigid coil connector through a welding joint , and the coil connector is connected with the coil , and the current-carrying pin is positioned on its end facing away from the connection region by the guiding piece that is slid onto the current-carrying pin, wherein the connection region is arranged in the casing of the solenoid and the guiding piece is supported on the casing , wherein the slid-on guiding piece pushes the pin provided for earthing the casing onto the electrically conducting casing .
A method of fixing an offshore structure to a pre-piled foundation pile , wherein the foundation pile comprises a tube piled into the sea floor and the offshore structure comprises a leg inserted into the foundation pile , wherein the method comprises applying grout to a first region (A) between an end portion of the leg and the sea floor within the foundation pile , allowing the grout to at least partially cure, and then applying grout to a second region (B), wherein the second region (B) is an annular region between the leg and the foundation pile .
Micromechanical sound transducer (1, 1', 1") for emitting sound, being set up in a substrate, comprising: a first bending transducer that extends along a plane of the substrate and comprises a free end or a free side and is configured to be excited to vibrate vertically in order to emit a sound; and a diaphragm element extending vertically to the first bending transducer , the diaphragm element being separated from the free end or the free side of the first bending transducer via a slit ; wherein the slit is smaller than 5% or smaller than 1% or smaller than 0.1% or smaller than 0.01% of the surface area of the first bending transducer and wherein, upon a deflection, the slit is smaller than 10%, 5%, 1%, 0.1% or 0.01% of the surface area of the first bending transducer . a first bending transducer that extends along a plane of the substrate and comprises a free end or a free side and is configured to be excited to vibrate vertically in order to emit a sound; and a diaphragm element extending vertically to the first bending transducer , the diaphragm element being separated from the free end or the free side of the first bending transducer via a slit ; wherein the slit is smaller than 5% or smaller than 1% or smaller than 0.1% or smaller than 0.01% of the surface area of the first bending transducer and wherein, upon a deflection, the slit is smaller than 10%, 5%, 1%, 0.1% or 0.01% of the surface area of the first bending transducer .