A compound of Formula (I): wherein: A is H; E is SO 2 ; X is Cl, Br, I, or OSO 2 R; Y is Cl, Br, I, or OSO 2 R; each R is independently H or C1-C6 alkyl; G is a radical selected from the group comprising Formulae (B)-(AA): wherein: R 1 is H, C1-C6 alkyl, CH 2 (CH 2 ) n OH, CH 2 CH(OH)CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 4 is N(R 6 )(R 7 ), OH, OCH 2 (CH 2 ) n N(R 6 )(R 7 ), or CH 2 (CH 2 ) n N(R 6 )(R 7 ); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2 , O, S, SO, or SO 2 ; n is 0 to 6; * represents a point of attachment to Formula (I); or a pharmaceutically acceptable salt thereof. A is H; E is SO 2 ; X is Cl, Br, I, or OSO 2 R; Y is Cl, Br, I, or OSO 2 R; each R is independently H or C1-C6 alkyl; G is a radical selected from the group comprising Formulae (B)-(AA): wherein: R 1 is H, C1-C6 alkyl, CH 2 (CH 2 ) n OH, CH 2 CH(OH)CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 4 is N(R 6 )(R 7 ), OH, OCH 2 (CH 2 ) n N(R 6 )(R 7 ), or CH 2 (CH 2 ) n N(R 6 )(R 7 ); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2 , O, S, SO, or SO 2 ; n is 0 to 6; * represents a point of attachment to Formula (I); R 1 is H, C1-C6 alkyl, CH 2 (CH 2 ) n OH, CH 2 CH(OH)CH 2 OH, phenyl, pyridinyl, benzyl, or pyridinylmethyl, provided that when R 1 is phenyl, pyridinyl, benzyl or pyridinylmethyl, R 1 is optionally substituted in any available position with C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 2 and R 3 are each independently H, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, OR 6 , N(R 6 )(R 7 ), CFH 2 , CF 2 H, CF 3 , F, Cl, Br, I, OCF 3 , COR 6 , CON(R 6 )(R 7 ), SOR 6 , SON(R 6 )(R 7 ), SO 2 R 6 , SO 2 N(R 6 )(R 7 ), CN, or NO 2 ; R 4 is N(R 6 )(R 7 ), OH, OCH 2 (CH 2 ) n N(R 6 )(R 7 ), or CH 2 (CH 2 ) n N(R 6 )(R 7 ); R 5 is H, or C1-C6 alkyl group; R 6 and R 7 are each independently H, or C1-6 alkyl, or R 6 and R 7 taken together form a substituted or unsubstituted 5- or 6-membered heterocyclic ring; Z is CH or N; W is CH 2 , O, S, SO, or SO 2 ; n is 0 to 6; * represents a point of attachment to Formula (I); <EOS>