mhurhangee/patent-ind-claim-en huggingface dataset:
A fluid flow throttle valve that keeps the pressure of a fluid flow pumped into a system by a high-pressure pump constant and that is particularly suitable as a reject valve for maintaining the system pressure of a reverse osmosis device at a pressure level of <20 bar, wherein the valve comprises a tubular body , where flow enters from one end thereof, and the body is provided with a central outflow channel with a circular cross-section, having a cone arranged therein with its narrower end on the inflow side and being axially supported on a stem to which a support plate movable along with the stem is supported on the inflow side, wherein the outer edge of the support plate is closely tangential to the inner surface of the body and wherein the support plate is provided with channels for flow therethrough, and wherein a loaded compression spring surrounding the stem is provided between the outflow channel and the support plate , the compression spring being supported to the support plate from its one end and to the body from its other end, characterized in that a motion restrictor is supported to the larger diameter end of the cone , the motion restrictor consisting of a restrictor member and restrictor legs supported to the restrictor member and extending from the restrictor member to a planar surface surrounding the outflow end of the outflow channel , wherein the restrictor legs are adapted to restrict the motion of the cone such that the cone is prevented from being pressed against the circumference of the outflow end of the outflow channel by the force generated by the spring , as a result of which the cone always permits an evenly surrounding bypass flow permitted to flow between the restrictor legs and further through a flow-permitting channel between the restrictor member and the body .
A pharmaceutical composition containing an antibody-drug conjugate or a salt thereof as an active component, and a pharmaceutically acceptable formulation component, wherein the antibody-drug conjugate is an antibody-drug conjugate wherein an antitumor compound represented by the following formula: is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L 1 -L 2 -L P -NH-(CH 2 )n 1 -L a -(CH 2 )n 2 -C(=O)- via a thioether bond which is formed at a disulfide bond moiety present in the hinge part of the anti-HER2 antibody, wherein the anti-HER2 antibody is connected to the terminal L 1 , the antitumor compound is connected to the carbonyl group of the -(CH 2 )n 2 -C(=O)- moiety with the nitrogen atom of the amino group at position 1 as the connecting position, wherein n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, L 1 represents - (Succinimid-3-yl-N) - (CH 2 )n 3 -C(=O)-, wherein n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents the tetrapeptide residue -GGFG-, L a represents -O- or a single bond, and -(Succinimid-3-yl-N)- has a structure represented by the following formula: which is connected to the anti-HER2 antibody at position 3 thereof and is connected to the methylene group in the linker structure containing this structure on the nitrogen atom at position 1, for use in the treatment of HER2-low expressing cancer. via a thioether bond which is formed at a disulfide bond moiety present in the hinge part of the anti-HER2 antibody, wherein the anti-HER2 antibody is connected to the terminal L 1 , the antitumor compound is connected to the carbonyl group of the -(CH 2 )n 2 -C(=O)- moiety with the nitrogen atom of the amino group at position 1 as the connecting position, wherein n 1 represents an integer of 0 to 6, n 2 represents an integer of 0 to 5, L 1 represents - (Succinimid-3-yl-N) - (CH 2 )n 3 -C(=O)-, wherein n 3 represents an integer of 2 to 8, L 2 represents -NH-(CH 2 CH 2 -O)n 4 -CH 2 CH 2 -C(=O)- or a single bond, wherein n 4 represents an integer of 1 to 6, L P represents the tetrapeptide residue -GGFG-, L a represents -O- or a single bond, and -(Succinimid-3-yl-N)- has a structure represented by the following formula: which is connected to the anti-HER2 antibody at position 3 thereof and is connected to the methylene group in the linker structure containing this structure on the nitrogen atom at position 1, for use in the treatment of HER2-low expressing cancer.
A method for secure transmissions on a broadcast channel, the method comprising: obtaining a short term key for a message for transmission; obtaining a broadcast access key for the message, the broadcast access key corresponding to an access key identifier ; encrypting the message with the short term key; forming a packet header comprising the access key identifier and a random value ; and transmitting the encrypted message with the packet header on the broadcast channel, wherein the short term key is a function of the broadcast access key and the random value. obtaining a short term key for a message for transmission; obtaining a broadcast access key for the message, the broadcast access key corresponding to an access key identifier ; encrypting the message with the short term key; forming a packet header comprising the access key identifier and a random value ; and transmitting the encrypted message with the packet header on the broadcast channel, wherein the short term key is a function of the broadcast access key and the random value.
A composition comprising synthetic nanocarriers comprising: a hydrophobic carrier material, a rapalog, and a non-ionic surfactant with a hydrophilic-lipophilic balance (HLB) value less than or equal to 10; optionally wherein the composition is initially sterile filterable through a 0.22 μm filter. a hydrophobic carrier material, a rapalog, and a non-ionic surfactant with a hydrophilic-lipophilic balance (HLB) value less than or equal to 10;
Bridging element for connecting a first component, which is designed as a building element and/or substructure , to a second component, wherein the bridging element has a static load-bearing function and comprises at least one primary element and at least one attachment element , which can be connected so as to engage in one another, as a result of which the primary element and the attachment element are designed to be adjustable in length relative to one another, wherein the bridging element comprises two fastening means (18, 18', 18", 18"'), wherein one opening for the fastening means (18, 18', 18", 18"') is formed at both the proximal end and the distal end of the bridging element relative to the first component, wherein the fastening means (18, 18', 18", 18"') each comprise at least one washer (26, 26', 26") and/or one nut (24, 24"), wherein the openings have a circular shape, the diameter of which is designed to be somewhat greater than the fastening means (18, 18', 18", 18"') and/or which is designed as a slot, and wherein the arrangement of the fastening means (18, 18', 18", 18"') is selectable within the openings by the fastening means (18, 18', 18", 18"') being able to be moved back and forth inside the openings within their limits, and this can result in limited adjustability of the position of the fastening means (18, 18', 18", 18′′′). characterised in that the primary element and the attachment element are designed to be able to slide into one another along a groove and are rotatable for fixing a length position.
A multi-purpose sealing device for a port structure in a fiber terminal, enclosure or bulkhead, the sealing device comprising: a body having an open end and a closed end , wherein the closed end includes a removable portion and a pulling device to facilitate removal of the sealing device from a port structure , the removable portion being configured to create an insertion opening in the sealing device for inserting an optical fiber connector in the sealing device after extraction of the removable portion , and a connection portion configured to secure the sealing device in the port structure . a body having an open end and a closed end , wherein the closed end includes a removable portion and a pulling device to facilitate removal of the sealing device from a port structure , the removable portion being configured to create an insertion opening in the sealing device for inserting an optical fiber connector in the sealing device after extraction of the removable portion , and a connection portion configured to secure the sealing device in the port structure .
Dental treatment unit, having - a joint part , - a swing arm , which is arranged to be pivotable relative to the joint part about a rotation axis (D), and - a brake arrangement for inhibiting the pivotability of the swing arm about the rotation axis (D), characterized in that the brake arrangement has a stack formed by discs , wherein the discs bear on each other under a contact pressure, wherein the discs comprise a plurality of first discs of a first material and a plurality of second discs of a second material, and wherein the first discs are arranged in a rotationally fixed manner relative to the swing arm and the second discs are arranged in a rotationally fixed manner relative to the joint part . - a joint part , - a swing arm , which is arranged to be pivotable relative to the joint part about a rotation axis (D), and - a brake arrangement for inhibiting the pivotability of the swing arm about the rotation axis (D), characterized in that the brake arrangement has a stack formed by discs , wherein the discs bear on each other under a contact pressure, wherein the discs comprise a plurality of first discs of a first material and a plurality of second discs of a second material, and wherein the first discs are arranged in a rotationally fixed manner relative to the swing arm and the second discs are arranged in a rotationally fixed manner relative to the joint part .
A flat waveguide-type laser device, comprising: an isotropic medium of a flat plate shape extending in an x- and z-direction and having a thickness in a y-direction, for transmitting a laser beam, having a travelling direction along the z-axis, incident from a side surface of the isotropic medium; and a cladding bonded to at least one of an upper surface and a lower surface of the isotropic medium, the cladding including a birefringent crystal having two different refractive indexes in two polarization directions perpendicular to the z-axis parallel to the traveling direction of the laser beam in the isotropic medium , and the isotropic medium including a material having a refractive index between the two different refractive indexes in the two polarization directions in the cladding , characterised in that an optical axis of the cladding is parallel to a bonded surface between the isotropic medium and the cladding, and is tilted relative to the travelling direction of the laser beam in the isotropic medium , the optical axis having a tilt angle(θ) within the xz-plane or yz-plane; wherein the optical axis of the cladding is the c-axis of the birefringent crystal. an isotropic medium of a flat plate shape extending in an x- and z-direction and having a thickness in a y-direction, for transmitting a laser beam, having a travelling direction along the z-axis, incident from a side surface of the isotropic medium; and a cladding bonded to at least one of an upper surface and a lower surface of the isotropic medium, the cladding including a birefringent crystal having two different refractive indexes in two polarization directions perpendicular to the z-axis parallel to the traveling direction of the laser beam in the isotropic medium , and the isotropic medium including a material having a refractive index between the two different refractive indexes in the two polarization directions in the cladding , characterised in that an optical axis of the cladding is parallel to a bonded surface between the isotropic medium and the cladding, and is tilted relative to the travelling direction of the laser beam in the isotropic medium , the optical axis having a tilt angle(θ) within the xz-plane or yz-plane; wherein the optical axis of the cladding is the c-axis of the birefringent crystal.
An optical system comprising a plurality of optical elements (L1 - L12) which are arranged between an object and an image plane, wherein at least one of the plurality of optical elements (L1 - L12) comprises: a base material ; and an optical thin film which is applied to at least one of optical surfaces of the base material , wherein the optical thin film comprises: MgF2 minute particles ; and an amorphous silicon oxide-based binder which exists between the MgF2 minute particles ,and wherein the optical thin film has a porous structure, wherein the at least one of the optical surfaces is formed to have one of a flat surface and a curved surface, wherein the optical system is an imaging optical system or an observation optical system, and wherein a multilayered optical thin film comprising a plurality of stacked optical thin films is applied to the at least one of optical surfaces of the base material , and the optical thin film is formed as an outermost layer of the stacked optical thin films, and has a refractive index of not more than 1.30. a base material ; and an optical thin film which is applied to at least one of optical surfaces of the base material , wherein the optical thin film comprises: MgF2 minute particles ; and an amorphous silicon oxide-based binder which exists between the MgF2 minute particles ,and wherein the optical thin film has a porous structure, wherein the at least one of the optical surfaces is formed to have one of a flat surface and a curved surface, wherein the optical system is an imaging optical system or an observation optical system, and wherein a multilayered optical thin film comprising a plurality of stacked optical thin films is applied to the at least one of optical surfaces of the base material , and the optical thin film is formed as an outermost layer of the stacked optical thin films, and has a refractive index of not more than 1.30. MgF2 minute particles ; and an amorphous silicon oxide-based binder which exists between the MgF2 minute particles ,and wherein the optical thin film has a porous structure, wherein the at least one of the optical surfaces is formed to have one of a flat surface and a curved surface, wherein the optical system is an imaging optical system or an observation optical system, and wherein a multilayered optical thin film comprising a plurality of stacked optical thin films is applied to the at least one of optical surfaces of the base material , and the optical thin film is formed as an outermost layer of the stacked optical thin films, and has a refractive index of not more than 1.30.
A method for producing a surface structure of a large-format pressing tool with at least one edge length amounting to more than one meter, in particular a press plate or an endless belt, for pressing material sheets, plastic films, separating films, PVC surfaces and LVTs (luxury vinyl tiles), check cards, passports, credit cards or plastic cards, comprising at least the steps: - providing and using digitized data of a 3D topography of a surface structure , - generating digitized data of individual 2D layers of the 3D topography, - using the digitized data of the 2D layers in order to guide a processing head and/or to position it in an x-y plane, or to track a work table in the plane spanned by an x- and a y-coordinate relative to a processing head which is held stationary, in order to connect a layer material to an existing carrier material or an already completed layer as a function of the digitized data of the 2D layers , wherein the surface structure is subdivided, independently of a repeating pattern, into subregions which are each processed sequentially or are at least partially processed in parallel by several processing heads, and/or that the boundaries of the subregions are freely selectable and/or in that the defined subregions have an edge length amounting to 10 cm to 100 cm depending on the processing head that is used. - providing and using digitized data of a 3D topography of a surface structure , - generating digitized data of individual 2D layers of the 3D topography, - using the digitized data of the 2D layers in order to guide a processing head and/or to position it in an x-y plane, or to track a work table in the plane spanned by an x- and a y-coordinate relative to a processing head which is held stationary, in order to connect a layer material to an existing carrier material or an already completed layer as a function of the digitized data of the 2D layers ,
A method for preparing a compound of Formula 7 comprising the steps of: preparing the following compound of Formula 2 from the following compound of Formula 1 under a base; reacting the compound of Formula 2 with the following compound of Formula 2-1 under a base to produce the following compound of Formula 3; preparing the following compound of Formula 4 from the compound of Formula 3 under a base; reacting the compound of Formula 4 with the following compound of Formula 5 under a base to produce the following compound of Formula 6; and debenzylating the compound of Formula 6 to produce the following compound of Formula 7: [Formula 2-1] R 1 OR 2 OCHCH 2 CH 2 OH wherein Ts is toluenesulfonyl, Ms is methanesulfonyl, Bn is benzyl, R 1 and R 2 are each independently a linear or branched C 1 ~ C 9 alkyl group, and n is an integer from 3 to 2000. preparing the following compound of Formula 2 from the following compound of Formula 1 under a base; reacting the compound of Formula 2 with the following compound of Formula 2-1 under a base to produce the following compound of Formula 3; preparing the following compound of Formula 4 from the compound of Formula 3 under a base; reacting the compound of Formula 4 with the following compound of Formula 5 under a base to produce the following compound of Formula 6; and debenzylating the compound of Formula 6 to produce the following compound of Formula 7:
A vibration-reducing component comprising a compressible elastic element and a plurality of individual compression elements , wherein each said individual compression element is connected to said compressible elastic element at first and second locations of said compressible elastic element spaced in the direction of an elastic element axis, extends continuously along said compressible elastic element between said first and second spaced locations, and applies a compressive force for placing said elastic element into compression, wherein said plurality of individual compression elements comprises two said individual compression elements each of which is on a respective opposite side of said compressible elastic element transverse to said elastic element axis, and said two individual compression elements are coplanar, characterized in that each said individual compression element comprises a cable or rope-like device that applies said compressive force in the direction of said elastic element axis.
Shredding device, comprising: two shredding shafts arranged parallel to each other with shredding elements arranged thereon, wherein the shredding shafts are preferably rotatable mechanically synchronized to each other; a shaft-side coupling element which is connected to a respective first end of the shredding shafts; a housing with a housing-side coupling element which can be coupled to the shaft-side coupling element ; and a displacement device enabling displacement of the shredding shafts for decoupling and coupling the shaft-side coupling element from or to the housing-side coupling element ; an end wall in which two bearing housings are provided for supporting a respective second end of the shredding shafts ; wherein the second ends are opposite to the first ends in the axial direction of the shredding shafts ; and wherein the end wall is detachably fastened to the housing and can be installed and removed as a dual-shaft assembly of end wall and shredding shafts ; wherein the displacement device is coupled to the end wall in order to effect decoupling and coupling of the shaft-side coupling element from or to the housing-side coupling element , characterized in that the displacement device effects displacement of the dual-shaft assembly in the axial direction of the shredding shafts and withdrawal of the shaft-side coupling element from the housing-side coupling element ; wherein the end wall is supported on the housing after withdrawal. two shredding shafts arranged parallel to each other with shredding elements arranged thereon, wherein the shredding shafts are preferably rotatable mechanically synchronized to each other; a shaft-side coupling element which is connected to a respective first end of the shredding shafts; a housing with a housing-side coupling element which can be coupled to the shaft-side coupling element ; and a displacement device enabling displacement of the shredding shafts for decoupling and coupling the shaft-side coupling element from or to the housing-side coupling element ; an end wall in which two bearing housings are provided for supporting a respective second end of the shredding shafts ; wherein the second ends are opposite to the first ends in the axial direction of the shredding shafts ; and wherein the end wall is detachably fastened to the housing and can be installed and removed as a dual-shaft assembly of end wall and shredding shafts ; wherein the displacement device is coupled to the end wall in order to effect decoupling and coupling of the shaft-side coupling element from or to the housing-side coupling element , characterized in that the displacement device effects displacement of the dual-shaft assembly in the axial direction of the shredding shafts and withdrawal of the shaft-side coupling element from the housing-side coupling element ; wherein the end wall is supported on the housing after withdrawal.
An ink composition, comprising: an aqueous liquid vehicle; from 1 wt% to 9 wt% pigment dispersed in the aqueous liquid vehicle by an ionic polymeric dispersant associated with pigment; from 0.5 wt% to 5 wt% non-ionic polymeric binder having a weight average molecular weight from 400 Mw to 20,000 Mw; and from 0.1 wt% to 1.5 wt% monovalent salt. an aqueous liquid vehicle; from 1 wt% to 9 wt% pigment dispersed in the aqueous liquid vehicle by an ionic polymeric dispersant associated with pigment; from 0.5 wt% to 5 wt% non-ionic polymeric binder having a weight average molecular weight from 400 Mw to 20,000 Mw; and from 0.1 wt% to 1.5 wt% monovalent salt.
A method to produce a wear resistant foil , comprising providing a first foil comprising a first thermoplastic material, applying a second foil comprising a second thermoplastic material on the first foil , applying wear resistant particles on the first foil and/or on the second foil prior to applying the second foil on the first foil , and adhering the first foil to the second foil with the wear resistant particles therebetween for forming a wear resistant foil , characterised in that the wear resistant particles do not protrude from an upper surface of the second foil being opposite the first foil . providing a first foil comprising a first thermoplastic material, applying a second foil comprising a second thermoplastic material on the first foil , applying wear resistant particles on the first foil and/or on the second foil prior to applying the second foil on the first foil , and adhering the first foil to the second foil with the wear resistant particles therebetween for forming a wear resistant foil , characterised in that the wear resistant particles do not protrude from an upper surface of the second foil being opposite the first foil .