mhurhangee/patent-ind-claim-en huggingface dataset:
A device for continuous monitoring of subsurface macrovascular and microvascular blood flow rate and blood flow direction by interfacing with a skin surface in an in vivo biological environment, the device comprising: a flexible and stretchable substrate providing a conformable interface and mechanically matched to a skin surface and having a Young's modulus less than or equal to 100 MPa and a bending stiffness less than or equal to 1 mN m; and a thermal actuator and a plurality of thermal sensors supported by said flexible and stretchable substrate, wherein the thermal actuator is a central actuator that provides a constant source of thermal power to create a mild, well-controlled increase in temperature at the skin surface of less than 10°C, and external electronics in wired communication with the device, and the sensors by means of the external electronics determine a spatio-temporal distribution of temperature for characterizing a thermal transport property of said skin; wherein said flexible and stretchable substrate, said thermal actuator and said plurality of thermal sensors provide a net bending stiffness such that the device is capable of establishing conformal contact with the skin surface; wherein the central thermal actuator provides a power input of between 0.1 to 50 mW/mm 2 to the skin surface; wherein said thermal sensors are symmetrically arranged with respect to said central thermal actuator and two of said thermal sensors form a matched pair on opposing sides of said central thermal actuator for obtaining comparative data as an indication of an anisotropic thermal transport property, wherein said anisotropic thermal transport property indicates a direction of blood flow within the vasculature below the surface of the skin; wherein the thermal actuator has a radius (B) and a distance (L) from the actuator edge to the thermal sensor center, with B/L between 1/3 to 1; wherein said actuator and/or said plurality of sensors are connected by an electronic circuit, wherein the electronic circuit is flexible or stretchable and comprises one or more electronic devices or device components having a curved, serpentine, bent, wavy or buckled geometry; wherein said sensors and the actuator are at least partially encapsulated by a barrier layer. a flexible and stretchable substrate providing a conformable interface and mechanically matched to a skin surface and having a Young's modulus less than or equal to 100 MPa and a bending stiffness less than or equal to 1 mN m; and a thermal actuator and a plurality of thermal sensors supported by said flexible and stretchable substrate, wherein the thermal actuator is a central actuator that provides a constant source of thermal power to create a mild, well-controlled increase in temperature at the skin surface of less than 10°C, and external electronics in wired communication with the device, and the sensors by means of the external electronics determine a spatio-temporal distribution of temperature for characterizing a thermal transport property of said skin;
A stent apparatus with self-folded skirt , comprising a stent which has a first configuration before being released and a second configuration after being released that is different from the first configuration, the stent apparatus having a flexible skirt , characterized by the flexible skirt having: an unfolded configuration, in which the skirt is axially unfolded and surrounding an outer periphery of the stent before being released; a stacked configuration, in which the skirt is folded and stacked in an axial direction of the stent after being released and forms an annular peripheral leakage occluder; at least a portion of the skirt is fixed on the stent , and the stent apparatus is further provided with a pulling string that only threads through the skirt , wherein, the pulling string undulates in the axial direction of the stent while extending in a circumferential direction of the stent and thus form a wave-like configuration, and a wave shape of the pulling string is changed when the pulling string is driven by a deformation of the stent during release so as to pull the skirt into the stacked configuration. an unfolded configuration, in which the skirt is axially unfolded and surrounding an outer periphery of the stent before being released; a stacked configuration, in which the skirt is folded and stacked in an axial direction of the stent after being released and forms an annular peripheral leakage occluder; at least a portion of the skirt is fixed on the stent , and the stent apparatus is further provided with a pulling string that only threads through the skirt , wherein, the pulling string undulates in the axial direction of the stent while extending in a circumferential direction of the stent and thus form a wave-like configuration, and a wave shape of the pulling string is changed when the pulling string is driven by a deformation of the stent during release so as to pull the skirt into the stacked configuration.
A method for communicating non-Internet Protocol, IP, data over a packet data network, PDN, of PDN type IPv4, IPv6, or IPv4IPv6, the method being performed by a core network gateway node , the method comprising: allocating (S304) an Internet Protocol, IP, address for a portable wireless device without providing the IP address to the portable wireless device; communicating (S102, S311) IP packets over a packet data network of PDN type IPv 4 , IPv6, or IPv4IPv6 with an application server , said IP packets comprising an IP header that comprises the IP address of the portable wireless device, and a User Datagram Protocol, UDP, header ; and communicating (S110, S311) header-less payload packets over a PDN connection with said portable wireless device by mapping the IP address to a Tunnel endpoint identifier, TEID, and removing said IP and UDP headers from said IP packets, wherein said header-less payload packets represent said non-IP data. allocating (S304) an Internet Protocol, IP, address for a portable wireless device without providing the IP address to the portable wireless device; communicating (S102, S311) IP packets over a packet data network of PDN type IPv 4 , IPv6, or IPv4IPv6 with an application server , said IP packets comprising an IP header that comprises the IP address of the portable wireless device, and a User Datagram Protocol, UDP, header ; and communicating (S110, S311) header-less payload packets over a PDN connection with said portable wireless device by mapping the IP address to a Tunnel endpoint identifier, TEID, and removing said IP and UDP headers from said IP packets, wherein said header-less payload packets represent said non-IP data.
A method of identifying a cross-species mutant antibody from a template antibody of a species, wherein the template antibody shows an activity on a first target from the species and the template antibody has six complementarity determining regions together comprising n amino acid residues, the method comprising the steps of: i. generating a library of n separate sets mutant antibodies from the template antibody, each set comprising mutant antibodies having X number of different predetermined amino acid residues at a single predetermined position of one of the six complementarity determining regions; wherein each set of mutant antibodies differs in the single predetermined position; and the number of different mutant antibodies generated is equivalent to n x X; ii. selecting mutant antibodies that show the activity on an ortholog of the first target in another species; and iii. screening the selected mutant antibodies for a cross-species mutant antibody that shows the activity on the first target. i. generating a library of n separate sets mutant antibodies from the template antibody, each set comprising mutant antibodies having X number of different predetermined amino acid residues at a single predetermined position of one of the six complementarity determining regions; wherein each set of mutant antibodies differs in the single predetermined position; and the number of different mutant antibodies generated is equivalent to n x X; ii. selecting mutant antibodies that show the activity on an ortholog of the first target in another species; and iii. screening the selected mutant antibodies for a cross-species mutant antibody that shows the activity on the first target.
A method of determining at least one point of entry of smoke into a smoke detection system , the system having a sampling pipe network including at least one sampling pipe and a plurality of sampling inlets through which an air sample can enter the at least one sampling pipe of the smoke detection system for analysis by a particle detector , said method including: determining through which sampling inlet of the plurality of sampling inlets the smoke entered the smoke detection system, characterised by determining a volume of sample air that has passed through at least part of the smoke detection system since a predetermined event, wherein said determining through which sampling inlet of the plurality of sampling inlets the smoke entered the smoke detection system is based on the determined volume. determining through which sampling inlet of the plurality of sampling inlets the smoke entered the smoke detection system, characterised by determining a volume of sample air that has passed through at least part of the smoke detection system since a predetermined event, wherein said determining through which sampling inlet of the plurality of sampling inlets the smoke entered the smoke detection system is based on the determined volume.
A method for determining cancer stage in a subject, comprising characterizing selected characteristics of circulating Cancer Associated Macrophage-Like cells (CAMLs) in a biological sample from a subject having a cancer, wherein said characterizing indicates cancer stage in the subject, wherein the selected characteristics are (i) number of CAMLs and (ii) average size of CAMLs, and wherein when measured in a sample of peripheral blood in a volume of 7.5ml, then 5 or more CAMLs and about 70% CAMLs larger than 40 microns in diameter is indicative of stage III cancer; and 5 or more CAMLs and about 80% CAMLs larger than 40 microns in diameter is indicative of stage IV cancer.
A method for providing a Virtual Network Function, VNF, for deployment in a Network Function Virtualization Infrastructure, NFVI, comprising: obtaining an input including a description of available software components, configuration requirements specifying service types to be provided by the VNF, and infrastructure information specifying resources provided by the NFVI, wherein the infrastructure information includes characteristics of virtual machines, VMs; generating , for each service type, a VNF component, VNFC, configuration that optimizes usage of the resources and satisfies a requested service availability; forming a VNF configuration including a collection of VNFC configurations generated for the service types; and delivering the VNF configuration to a Network Function Virtualization, NFV, system for the deployment of VNFC instances on the VMs thereby providing the VNF, wherein generating the VNFC configuration that optimizes the usage of the resources further comprises: generating candidate configurations for each service type; and selecting, from the candidate configurations generated for each service type, the VNFC configuration that uses a minimum number of physical hosts, wherein the method further comprises determining a maximum number of service instances, SIs, collocated per VM that satisfies the requested service availability. obtaining an input including a description of available software components, configuration requirements specifying service types to be provided by the VNF, and infrastructure information specifying resources provided by the NFVI, wherein the infrastructure information includes characteristics of virtual machines, VMs; generating , for each service type, a VNF component, VNFC, configuration that optimizes usage of the resources and satisfies a requested service availability; forming a VNF configuration including a collection of VNFC configurations generated for the service types; and delivering the VNF configuration to a Network Function Virtualization, NFV, system for the deployment of VNFC instances on the VMs thereby providing the VNF, wherein generating the VNFC configuration that optimizes the usage of the resources further comprises: generating candidate configurations for each service type; and selecting, from the candidate configurations generated for each service type, the VNFC configuration that uses a minimum number of physical hosts, wherein the method further comprises determining a maximum number of service instances, SIs, collocated per VM that satisfies the requested service availability. generating candidate configurations for each service type; and selecting, from the candidate configurations generated for each service type, the VNFC configuration that uses a minimum number of physical hosts, wherein the method further comprises determining a maximum number of service instances, SIs, collocated per VM that satisfies the requested service availability.
A method to generate an output signal from a chemical detection circuit, comprising: selecting a chemical detection pixel (3302.1) from a column of chemical detection pixels for readout, wherein the chemical detection pixel (3302.1) comprises a chemically-sensitive transistor (3304.1) that is an ion-sensitive field effect transistor (ISFET) and the column of chemical detection pixels comprises a current source , a plurality of chemical detection pixels, an amplifier , and a capacitor , wherein the chemically-sensitive transistor (3304.1) has a first terminal connected to a first side of a row-select switch (3306.1) and a second terminal connected to ground, the row-select switch (3306.1) having a second side that is connected to the current source and is coupled to an input of the amplifier , and wherein the capacitor and the amplifier form an integrator that is shared by the column of chemical detection pixels; providing a direct current bias current from the current source to the chemical detection pixel (3302.1); integrating a readout current from the chemical detection pixel (3302.1) to the integrator, wherein the readout current is read out from the chemical detection pixel (3302.1) through the same line of the chemical detection pixel (3302.1) through which the direct current bias current is provided to the chemical detection pixel (3302.1); and reading out an output voltage of the integrator. selecting a chemical detection pixel (3302.1) from a column of chemical detection pixels for readout, wherein the chemical detection pixel (3302.1) comprises a chemically-sensitive transistor (3304.1) that is an ion-sensitive field effect transistor (ISFET) and the column of chemical detection pixels comprises a current source , a plurality of chemical detection pixels, an amplifier , and a capacitor , wherein the chemically-sensitive transistor (3304.1) has a first terminal connected to a first side of a row-select switch (3306.1) and a second terminal connected to ground, the row-select switch (3306.1) having a second side that is connected to the current source and is coupled to an input of the amplifier , and wherein the capacitor and the amplifier form an integrator that is shared by the column of chemical detection pixels; providing a direct current bias current from the current source to the chemical detection pixel (3302.1); integrating a readout current from the chemical detection pixel (3302.1) to the integrator, wherein the readout current is read out from the chemical detection pixel (3302.1) through the same line of the chemical detection pixel (3302.1) through which the direct current bias current is provided to the chemical detection pixel (3302.1); and reading out an output voltage of the integrator.
Use of a composite material comprising: (a) a nonwoven as carrier material and (b) a textile layer of reinforcing fibres, wherein the reinforcing fibres consist of mono- or multifilaments or tapes and the carrier material is adhesively bonded to the layer of reinforcing fibres, as a transfer system for application to surfaces for increasing the roughness and/or grip. (a) a nonwoven as carrier material and (b) a textile layer of reinforcing fibres,
Endoscopic instrument for introduction into a body of a patient, wherein the instrument comprises a tubular shaft and at least two electrical, mechanical and/or optical lines extending through the shaft , wherein the lines comprise at least two tension wires which extend in a diametrically opposed manner though the shaft on an inner surface of the shaft, wherein the shaft in a bendable shaft section has a plurality of slits at an axial distance with regard to each other, wherein in the circumferential direction, the slits only extend over a part of the shaft circumference and wherein the slits are axially arranged in relation to each other so that alternately they lie on a first lateral side of the shaft and on a second lateral side of the shaft which is diametrically opposite the first lateral side, wherein the bendable shaft section has at least two sub-sections (Y, Z), wherein the distances between the slits in a first sub-section (Y) of the at least two sub-sections (Y, Z) is smaller than in a second sub-section (Z) of the at least two sub-sections (Y, Z), wherein the first sub-section (Y) is arranged distally of the second sub-section (Z), characterised in that that slits are wedge-shaped so that the clear width of the slits centrally, where the tension wires run is largest and narrow towards the ends in the circumferential direction, wherein the ends of the slits have round recesses, wherein the clear width of the slits in the first sub-section (Y) is greater than in the second sub-section (Z). wherein the shaft in a bendable shaft section has a plurality of slits at an axial distance with regard to each other, wherein in the circumferential direction, the slits only extend over a part of the shaft circumference and wherein the slits are axially arranged in relation to each other so that alternately they lie on a first lateral side of the shaft and on a second lateral side of the shaft which is diametrically opposite the first lateral side, wherein the bendable shaft section has at least two sub-sections (Y, Z), wherein the distances between the slits in a first sub-section (Y) of the at least two sub-sections (Y, Z) is smaller than in a second sub-section (Z) of the at least two sub-sections (Y, Z), wherein the first sub-section (Y) is arranged distally of the second sub-section (Z), characterised in that that slits are wedge-shaped so that the clear width of the slits centrally, where the tension wires run is largest and narrow towards the ends in the circumferential direction, wherein the ends of the slits have round recesses, wherein the clear width of the slits in the first sub-section (Y) is greater than in the second sub-section (Z).
An optical element , comprising: a transparent optical substrate ; a semiconductor coating deposited on a surface of the optical substrate and comprising a plurality of channels formed in the coating; and characterized by : an electrically conductive, doped semiconductor material deposited in the plurality of channels , wherein the plurality of channels form a grid pattern on the optical substrate ; and wherein a ratio of the indices of refraction of the doped semiconductor material and the semiconductor coating is between 0.82 and 1.22. a transparent optical substrate ; a semiconductor coating deposited on a surface of the optical substrate and comprising a plurality of channels formed in the coating; and characterized by : an electrically conductive, doped semiconductor material deposited in the plurality of channels , wherein the plurality of channels form a grid pattern on the optical substrate ; and wherein a ratio of the indices of refraction of the doped semiconductor material and the semiconductor coating is between 0.82 and 1.22. an electrically conductive, doped semiconductor material deposited in the plurality of channels , wherein the plurality of channels form a grid pattern on the optical substrate ; and wherein a ratio of the indices of refraction of the doped semiconductor material and the semiconductor coating is between 0.82 and 1.22.
A method of manufacturing a charged material transportation chamber comprising: depositing resistive ink to form a patterned resistive trace on an interior surface of a tube of unitary construction formed of at least one of substantially non-conductive material or semi-conductive material, the patterned resistive trace configured to connect to a source of electrical energy; and connecting the patterned resistive trace to a connector of the chamber, the connector configured to connect the patterned resistive trace to the source of electrical energy. configured to connect to a source of electrical energy; and connecting the patterned resistive trace to a connector of the chamber, the connector configured to connect the patterned resistive trace to the source of electrical energy.
A peptide having up to 50 amino acids in length and comprising SEQUENCE ID NO. 245, or a cellular growth promoting variant of SEQUENCE ID NO. 245, the variant having 1 to 3 amino acid alterations compared SEQUENCE ID NO. 245, in which the or each amino acid alteration is selected from insertion, addition, deletion and substitution of an amino acid.
An outer rotor electric machine (I), said electric machine (I) comprising a rotatably arranged rotor (10; 110; 210) and a stator comprising windings comprising opposite coil ends at axially opposing sides of the stator , said rotor comprising an outer rotor portion surrounding said stator or part of said stator and a flywheel portion (14; 114; 214), wherein one of said coil ends of said stator is arranged to face said flywheel portion (14; 114; 214), wherein said electric machine (I) is associated with a combustion engine for driving said rotor, said flywheel portion of said rotor constituting a flywheel for said combustion engine , said internal combustion engine comprising a crankshaft directly connected to said flywheel portion of the rotor, said flywheel portion (14; 114; 214) being of electro-magnetically conductive material, wherein, during operation of said outer rotor electric machine, the magnetic field generated by the winding coils changes when excited by a variable frequency current, wherein said nonrotating stator windings causes eddy currents in the rotating flywheel portion, said eddy currents causing thermal losses in the electric machine (I), said electric machine comprising an arrangement (O1, S1; O2, S2; O3, S3) configured to reduce such eddy current caused thermal losses of the outer rotor electric machine (I), said arrangement comprising a plurality of openings (O1; O2; O3) distributed on said flywheel portion (14; 114; 214) so that said coil end facing said flywheel portion faces said openings (O1; O2; O3) so as to reduce appearance of said eddy currents associated with said flywheel portion (14; 114; 214) during operation of said electric machine (I).