mhurhangee/patent-ind-claim-en huggingface dataset:
An in vitro method for expressing a nucleic acid of interest in a B cell comprising, (a) contacting memory B cells with a composition comprising CD40L in combination with a B cell activating factor comprising one or more of the factors selected from the group consisting of IL-2, IL-10, IL-15, and p-ODN; (b) contacting the B cells of (a) with a B cell activating factor comprising one or more of the factors selected from the group consisting of IL-2, IL-10, IL-6 and IL-15; under conditions such that the B cells in (b) express CD38; (c) transducing the B cells in (b) with a retroviral vector pseudotyped with VSV-G, wherein said retroviral vector comprises the nucleic acid of interest operably linked to a promoter; and (d) contacting the transduced B cells of (c) with a B cell activating factor comprising one or more of the factors selected from the group consisting of IFN-α; IFN-δ, IL-6 and IL-15; thereby expressing the nucleic acid of interest in the B cell. (a) contacting memory B cells with a composition comprising CD40L in combination with a B cell activating factor comprising one or more of the factors selected from the group consisting of IL-2, IL-10, IL-15, and p-ODN; (b) contacting the B cells of (a) with a B cell activating factor comprising one or more of the factors selected from the group consisting of IL-2, IL-10, IL-6 and IL-15; under conditions such that the B cells in (b) express CD38; (c) transducing the B cells in (b) with a retroviral vector pseudotyped with VSV-G, wherein said retroviral vector comprises the nucleic acid of interest operably linked to a promoter; and (d) contacting the transduced B cells of (c) with a B cell activating factor comprising one or more of the factors selected from the group consisting of IFN-α; IFN-δ, IL-6 and IL-15; thereby expressing the nucleic acid of interest in the B cell.
A connecting structure between a cowl louver and a windshield such that the cowl louver has a rear end portion connected to a lower edge portion of the windshield , comprising: a windshield including: a laminated glass having a first glass plate disposed on an exterior side, a second glass plate disposed on an interior side and an interlayer bonding the first glass plate and the second glass plate ; the laminated glass having a cutout portion formed by removing a part of the second glass plate and the interlayer at a certain area of a lower edge portion of the laminated glass ; the first glass plate having a power feed portion disposed on an interior side surface thereof in the cutout portion ; a spacer disposed in the cutout portion on a lower edge side of the windshield closer than the power feed portion; a cowl louver ; characterized in that the cowl louver includes a clamping portion formed in a U-character shape in section at a rear end portion thereof, the clamping portion having an upper member disposed along the first glass plate and a lower member disposed so as to be close to the second glass plate ; and the clamping portion clamps the first glass plate and the spacer , wherein the shape on an interior side of a front end portion of the spacer is the same shape as the shape on an interior side of a front end portion of the second glass plate except for the cutout portion , wherein the front end portion of the spacer has an interior side surface formed in a curved shape, and wherein a front end portion of the first glass plate and the front end portion of the second glass plate are formed in a chamfered shape. a laminated glass having a first glass plate disposed on an exterior side, a second glass plate disposed on an interior side and an interlayer bonding the first glass plate and the second glass plate ; the laminated glass having a cutout portion formed by removing a part of the second glass plate and the interlayer at a certain area of a lower edge portion of the laminated glass ; the first glass plate having a power feed portion disposed on an interior side surface thereof in the cutout portion ; a spacer disposed in the cutout portion on a lower edge side of the windshield closer than the power feed portion; a cowl louver ; characterized in that the cowl louver includes a clamping portion formed in a U-character shape in section at a rear end portion thereof, the clamping portion having an upper member disposed along the first glass plate and a lower member disposed so as to be close to the second glass plate ; and the clamping portion clamps the first glass plate and the spacer , wherein the shape on an interior side of a front end portion of the spacer is the same shape as the shape on an interior side of a front end portion of the second glass plate except for the cutout portion , wherein the front end portion of the spacer has an interior side surface formed in a curved shape, and wherein a front end portion of the first glass plate and the front end portion of the second glass plate are formed in a chamfered shape.
A method of selecting a subject for treatment with a receptor tyrosine kinase (RTK) inhibitor, the method comprising the steps of: (i) providing a test sample obtained from the subject wherein the sample contains cells expressing the RTK; (ii) imaging RTK molecules at the cell surface; (iii) determining the nanometre (nm) spatial separation between RTK molecules assembled in any RTK oligomer(s) located at the cell surface; (iv) comparing the nanometre (nm) spatial separation determined in (iii) with the nanometre (nm) spatial separation determined for equivalent RTK molecules assembled in any RTK oligomer(s) located at the cell surface in a control sample, wherein the comparison between control and test sample is used to determine the presence of one or more mutations in the RTK in the test sample, wherein the one or more mutations is substitution of one or more amino acids; and wherein the subject is selected for treatment if one or more mutations in the RTK are present. (i) providing a test sample obtained from the subject wherein the sample contains cells expressing the RTK; (ii) imaging RTK molecules at the cell surface; (iii) determining the nanometre (nm) spatial separation between RTK molecules assembled in any RTK oligomer(s) located at the cell surface; (iv) comparing the nanometre (nm) spatial separation determined in (iii) with the nanometre (nm) spatial separation determined for equivalent RTK molecules assembled in any RTK oligomer(s) located at the cell surface in a control sample, wherein the comparison between control and test sample is used to determine the presence of one or more mutations in the RTK in the test sample, wherein the one or more mutations is substitution of one or more amino acids; and wherein the subject is selected for treatment if one or more mutations in the RTK are present.
A flame-retardant coating composition comprising: a liquid carrier; a flame-retardant blend comprising a phosphate compound and a metal complexing agent; and characterized in that the phosphate compound and the metal complexing agent are present in a weight ratio ranging from about 50:1 to about 200:1 and in that the liquid carrier is water, and wherein the metal complexing agent comprises a metal ion and one or more phosphate, arsenate, or organic ligands. a liquid carrier; a flame-retardant blend comprising a phosphate compound and a metal complexing agent; and characterized in that the phosphate compound and the metal complexing agent are present in a weight ratio ranging from about 50:1 to about 200:1 and in that the liquid carrier is water, and wherein the metal complexing agent comprises a metal ion and one or more phosphate, arsenate, or organic ligands.
An apparatus, comprising: a housing ; a medicament container at least partially disposed within the housing, the medicament container containing a dose of a medicament; a carrier having an end portion coupled to a needle , and including a side wall defining a coupling volume within which an end portion of the medicament container is movably coupled, the medicament container fluidically isolated from a tip of the needle when the end portion of the medicament container is in a first container position within the coupling volume , the medicament container fluidically coupled to the tip of the needle when the end portion of the medicament container is in a second container position within the coupling volume , the side wall including an annular protrusion; and an energy storage member within the housing, the energy storage member configured to produce a force to move the medicament container from the first container position to the second container position, a portion of the force exerted to move a plunger within the medicament container to expel the dose of the medicament when the medicament container is in the second container position; characterized in that the annular protrusion defines a bleed passageway placing the coupling volume in fluid communication with a volume outside of the coupling volume . a housing ; a medicament container at least partially disposed within the housing, the medicament container containing a dose of a medicament; a carrier having an end portion coupled to a needle , and including a side wall defining a coupling volume within which an end portion of the medicament container is movably coupled, the medicament container fluidically isolated from a tip of the needle when the end portion of the medicament container is in a first container position within the coupling volume , the medicament container fluidically coupled to the tip of the needle when the end portion of the medicament container is in a second container position within the coupling volume , the side wall including an annular protrusion; and an energy storage member within the housing, the energy storage member configured to produce a force to move the medicament container from the first container position to the second container position, a portion of the force exerted to move a plunger within the medicament container to expel the dose of the medicament when the medicament container is in the second container position; characterized in that the annular protrusion defines a bleed passageway placing the coupling volume in fluid communication with a volume outside of the coupling volume .
A stirrer head having a bearing boss , a bearing bushing , at least one stirrer vane and a coupling section , wherein the bearing boss has an external surface and an internal surface and the bearing bushing is form-fit into the bearing boss , resting on the internal surface , wherein the stirrer vane is connected to the coupling section and the external surface of the bearing boss , characterized in that the stirrer head has an identification device and the bearing boss has a through-opening between the external surface and the internal surface , the identification device is positioned in the through-opening and the stirrer vane closes the through-opening at the external surface .
A method of operating a tire pressure monitoring system comprising: sensing tire pressure information; storing the sensed tire pressure information in a transmission buffer ; executing a control program to transmit the tire pressure information from the transmission buffer to an external receiver device according to each of a plurality of communications protocols incorporated into the control program and not according to a manufacturers' code that identifies a protocol or format, wherein each of the protocols is transmitted in a predetermined block having a pre-defined format, characterized in that the each of the blocks are transmitted sequentially in a burst , wherein a null space separates each of the blocks in the burst . sensing tire pressure information; storing the sensed tire pressure information in a transmission buffer ; executing a control program to transmit the tire pressure information from the transmission buffer to an external receiver device according to each of a plurality of communications protocols incorporated into the control program and not according to a manufacturers' code that identifies a protocol or format, wherein each of the protocols is transmitted in a predetermined block having a pre-defined format, characterized in that the each of the blocks are transmitted sequentially in a burst , wherein a null space separates each of the blocks in the burst .
Device for converting solar radiation comprising: an inorganic luminescent material comprising a doped host material, wherein the doped host material is doped with Mn 5+ ions for converting radiation of the UV, visible and/or part of the near infrared band of the solar spectrum into radiation of a predetermined near-infrared band, preferably the near-infrared band between 1150 nm and 1250 nm, more preferably between 1180 nm and 1200 nm, which is the band around the emission peak of Mn 5+ ; or, wherein the doped host material includes elements Al, Si, O and N (SiAlON) and wherein the doped host material is doped with Sm 2+ and/or Tm 2+ ions for converting radiation of the UV, visible and/or part of the near infrared band of the solar spectrum into radiation of a predetermined visible red band, preferably the visible red band between 650 nm and 800 nm, which is the band around the emission peak of Mn 2+ ; and/or into radiation of a predetermined near-infrared band, preferably the near-infrared band between 1100 and 1200 nm, more preferably between 1130 nm and 1150 nm, which is th band around the emission peak of Tm 2+ ; and, at least one photovoltaic device for converting at least part of the converted radiation into electrical power. an inorganic luminescent material comprising a doped host material, wherein the doped host material is doped with Mn 5+ ions for converting radiation of the UV, visible and/or part of the near infrared band of the solar spectrum into radiation of a predetermined near-infrared band, preferably the near-infrared band between 1150 nm and 1250 nm, more preferably between 1180 nm and 1200 nm, which is the band around the emission peak of Mn 5+ ; or, wherein the doped host material includes elements Al, Si, O and N (SiAlON) and wherein the doped host material is doped with Sm 2+ and/or Tm 2+ ions for converting radiation of the UV, visible and/or part of the near infrared band of the solar spectrum into radiation of a predetermined visible red band, preferably the visible red band between 650 nm and 800 nm, which is the band around the emission peak of Mn 2+ ; and/or into radiation of a predetermined near-infrared band, preferably the near-infrared band between 1100 and 1200 nm, more preferably between 1130 nm and 1150 nm, which is th band around the emission peak of Tm 2+ ; and, at least one photovoltaic device for converting at least part of the converted radiation into electrical power.
A method for optical macro-twist determination on cylindrical workpieces using scattered light measurements, wherein the workpiece is illuminated in a skimming manner with a light beam in a predeterminable surface region perpendicularly to the rotation axis and the reflected diffraction images, assigned to a specific predeterminable rotational angle step (Δα) of the workpiece, are captured by a 2-dimensional CCD array and are stored, characterised in that all the individual adjacent scattered light images obtained in this way are compiled in sequence to form a 360° total scattered light distribution, wherein, should a twist be present, a diffraction image comprising the shaft is created which contains all the initial information for period length, twist direction and pitch, twist angle and twist depth and which is evaluated and processed to determine these in a way that the intensity maxima are determined from the intensities resulting from the summation of all line elements of the individual images and the period length (DP) of the twist structure is determined from their interval using the diffraction equation DP = mλ sin Θ i tan φ m where λ is the wavelength of the incident light, Θ i is the angle of incidence, m is the diffraction order and φ m is the azimuth angle of the diffraction maxima, which can be assigned to defined image lines of the panoramic total scattered light distribution, and subsequently the periodicity of the intensity distribution in the 1 st diffraction order is determined, which is a direct measure of the twist direction and pitch (G) of the twisted structure, and using this number and the determined period length (DP) DW = a tan DP * G D * π , the twist angle (DW) is calculated, D being the diameter of the cylindrical workpiece .
A reconfigurable satellite access point comprising: a transport-mounting structure; and at least one antenna integrated with the transport-mounting structure ; wherein the transport-mounting structure allows the satellite access point to be easily reconfigured between a shipping configuration and a deployed configuration, the satellite access point in the shipping configuration having a form factor of a shipping container which allows the satellite access point to be shipped to a remote satellite access site on earth and the satellite access point in the deployed configuration revealing the at least one antenna to the sky at the satellite access site; wherein the transport-mounting structure comprises a receptacle sub-structure , the receptacle sub-structure including a base and at least one wall, the base for mounting the satellite access point on the ground at the satellite access site and the at least one wall and the base enclosing the at least one antenna during shipping, the at least one wall comprising an end wall and a side wall , the end wall and the side wall each separately pivotally movable relative to the base, or the end wall and the side wall each separately detachable from the base, or the end wall and the side wall each separately pivotally movable relative to and detachable from the base, to reveal the at least one antenna to the sky at the satellite access site. a transport-mounting structure; and at least one antenna integrated with the transport-mounting structure ; wherein the transport-mounting structure allows the satellite access point to be easily reconfigured between a shipping configuration and a deployed configuration, the satellite access point in the shipping configuration having a form factor of a shipping container which allows the satellite access point to be shipped to a remote satellite access site on earth and the satellite access point in the deployed configuration revealing the at least one antenna to the sky at the satellite access site; wherein the transport-mounting structure comprises a receptacle sub-structure , the receptacle sub-structure including a base and at least one wall, the base for mounting the satellite access point on the ground at the satellite access site and the at least one wall and the base enclosing the at least one antenna during shipping, the at least one wall comprising an end wall and a side wall , the end wall and the side wall each separately pivotally movable relative to the base, or the end wall and the side wall each separately detachable from the base, or the end wall and the side wall each separately pivotally movable relative to and detachable from the base, to reveal the at least one antenna to the sky at the satellite access site.
A lubricant composition comprising a lubricant base oil (A) having a kinematic viscosity at 100°C, as determined according to JIS K2283, of 1 to 10 mm 2 /s, and an ethylene/α-olefin copolymer (B) having characteristics (B1) to (B4) described below in a weight ratio ((A)/(B)) of 99/1 to 50/50, the lubricant composition having a kinematic viscosity at 100°C, as determined according to JIS K2283, of not more than 20 mm 2 /s, the lubricant composition having a peak top of molecular weight in the range of 3,000 to 10,000 as measured by gel permeation chromatography (GPC) with reference to polystyrene standards, with the peak top molecular weight being the molecular weight that gives the highest maximum value of dw/dLog (M), wherein M is the molecular weight and w is the weight fraction of the component having the corresponding molecular weight, in a molecular weight distribution curve, wherein the molecular weight that is largest is taken as the peak top molecular weight in a case where the molecular weight distribution curve includes a plurality of peak tops of molecular weight in the range of 3,000 to 10,000, the lubricant composition having a weight fraction of components having a molecular weight not less than 20,000, measured with reference to polystyrene standards, of 1 to 10% relative to all components of the lubricant composition having a molecular weight not less than the molecular weight that gives the above peak top, (B1) the peak top molecular weight measured by gel permeation chromatography (GPC) with reference to polystyrene standards is 3,000 to 10,000, (B2) the copolymer shows no melting peak as measured on a differential scanning calorimeter (DSC), (B3) the value B represented by the equation below is not less than 1.1 B = P OE 2 P O ⋅ P E wherein P E is the molar fraction of ethylene components, P O is the molar fraction of α-olefin components, and P OE is the molar fraction of ethylene-α-olefin sequences relative to all dyad sequences, and P E , P O and P OE are determined via 13 C-NMR, (B4) the kinematic viscosity at 100°C is 140 to 500 mm 2 /s. (B1) the peak top molecular weight measured by gel permeation chromatography (GPC) with reference to polystyrene standards is 3,000 to 10,000, (B2) the copolymer shows no melting peak as measured on a differential scanning calorimeter (DSC), (B3) the value B represented by the equation below is not less than 1.1 B = P OE 2 P O ⋅ P E wherein P E is the molar fraction of ethylene components, P O is the molar fraction of α-olefin components, and P OE is the molar fraction of ethylene-α-olefin sequences relative to all dyad sequences, and P E , P O and P OE are determined via 13 C-NMR, (B4) the kinematic viscosity at 100°C is 140 to 500 mm 2 /s.
A negative pressure pump system comprising: a pump assembly comprising: an actuator ; and a diaphragm ; and a controller configured to control operation of the pump system, the controller further configured to: calculate at least one of an amplitude and an offset for a drive signal based at least in part on previously calculated parameters and a negative pressure setting wherein the previously calculated parameters comprise a plurality of calibrated amplitudes at a plurality of negative pressure settings; generate the drive signal with the at least one calculated amplitude and offset; and apply the drive signal to the pump system, thereby causing delivery of negative pressure wound therapy characterized in that the previously calculated parameters comprise a plurality of calibrated offsets at a plurality of negative pressure settings. a pump assembly comprising: an actuator ; and a diaphragm ; and an actuator ; and a diaphragm ; and a controller configured to control operation of the pump system, the controller further configured to: calculate at least one of an amplitude and an offset for a drive signal based at least in part on previously calculated parameters and a negative pressure setting wherein the previously calculated parameters comprise a plurality of calibrated amplitudes at a plurality of negative pressure settings; generate the drive signal with the at least one calculated amplitude and offset; and apply the drive signal to the pump system, thereby causing delivery of negative pressure wound therapy calculate at least one of an amplitude and an offset for a drive signal based at least in part on previously calculated parameters and a negative pressure setting wherein the previously calculated parameters comprise a plurality of calibrated amplitudes at a plurality of negative pressure settings; generate the drive signal with the at least one calculated amplitude and offset; and apply the drive signal to the pump system, thereby causing delivery of negative pressure wound therapy characterized in that the previously calculated parameters comprise a plurality of calibrated offsets at a plurality of negative pressure settings.