A method for providing a clotting factor VIII dosing regimen comprising: calculating an empirical estimate λ ζ of a patient's clotting factor VIII elimination rate constant based on two blood samples having been collected from the patient after an infusion of clotting factor VIII and wherein the empirical estimate λ ζ of the patient's clotting factor VIII elimination rate constant is calculated by obtaining an absolute value of a slope of a log-linear regression; calculating a population estimated clotting factor VIII elimination rate constant β; determining a ratio of λ ζ /β; determining, via a processor, an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients, the estimated pharmacokinetic profile based upon at least one of a body weight or an age of the patient such that: a first weighting factor is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is less than or equal to 1, and a second weighting factor, less than the first weighting factor, is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is greater than 1, such that patient-specific clearance data is weighted more heavily than population data; determining, via the processor, the clotting factor VIII dosing regimen for a specified dosing interval including (i) a dosage of a clotting factor VIII therapeutic and (ii) an estimated clotting factor VIII clearance for the patient over a time period based at least upon the estimated pharmacokinetic profile; and displaying the dosing regimen on a client device. calculating an empirical estimate λ ζ of a patient's clotting factor VIII elimination rate constant based on two blood samples having been collected from the patient after an infusion of clotting factor VIII and wherein the empirical estimate λ ζ of the patient's clotting factor VIII elimination rate constant is calculated by obtaining an absolute value of a slope of a log-linear regression; calculating a population estimated clotting factor VIII elimination rate constant β; determining a ratio of λ ζ /β; determining, via a processor, an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients, the estimated pharmacokinetic profile based upon at least one of a body weight or an age of the patient such that: a first weighting factor is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is less than or equal to 1, and a second weighting factor, less than the first weighting factor, is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is greater than 1, such that patient-specific clearance data is weighted more heavily than population data; a first weighting factor is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is less than or equal to 1, and a second weighting factor, less than the first weighting factor, is applied to the Bayesian model of pharmacokinetic profiles of sampled patients if the ratio of λ ζ /β is greater than 1, such that patient-specific clearance data is weighted more heavily than population data; determining, via the processor, the clotting factor VIII dosing regimen for a specified dosing interval including (i) a dosage of a clotting factor VIII therapeutic and (ii) an estimated clotting factor VIII clearance for the patient over a time period based at least upon the estimated pharmacokinetic profile; and displaying the dosing regimen on a client device. <EOS>