A closed system transfer device (CSTD) arrangement for storing a beneficial agent and transferring the beneficial agent to a destination port , the CSTD arrangement comprising: a primary container comprising a package for storing the beneficial agent comprising at least one flexible wall such that pressure in the primary container is substantially equalized to ambient pressure; a metering pump ; a delivery port for communicating the beneficial agent with the destination port ; and a valve in selective fluid communication with the primary container , the metering pump , and the delivery port , the valve comprising a valve housing , wherein: the primary container extends from the valve housing , the metering pump is joined to the valve housing , the delivery port is an opening in the valve housing configured to accommodate the destination port , the valve is moveable from a first configuration where it is not engaged with the destination port , to a second configuration where it is engaged with the destination port , in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port , in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container , and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump . a primary container comprising a package for storing the beneficial agent comprising at least one flexible wall such that pressure in the primary container is substantially equalized to ambient pressure; a metering pump ; a delivery port for communicating the beneficial agent with the destination port ; and a valve in selective fluid communication with the primary container , the metering pump , and the delivery port , the valve comprising a valve housing , wherein: the primary container extends from the valve housing , the metering pump is joined to the valve housing , the delivery port is an opening in the valve housing configured to accommodate the destination port , the valve is moveable from a first configuration where it is not engaged with the destination port , to a second configuration where it is engaged with the destination port , in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port , in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container , and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump . the primary container extends from the valve housing , the metering pump is joined to the valve housing , the delivery port is an opening in the valve housing configured to accommodate the destination port , the valve is moveable from a first configuration where it is not engaged with the destination port , to a second configuration where it is engaged with the destination port , in the first configuration the primary container and the metering pump are in fluid communication and neither is in fluid communication with the delivery port , in the second configuration the metering pump is in fluid communication with the delivery port and neither is in fluid communication with the primary container , and the flexible wall collapses when the beneficial agent is transferred from the primary container to the metering pump . <EOS>