mhurhangee/patent-ind-claim-en huggingface dataset:
A method for determining binding constants for a molecular interaction between a first binding partner A and a second binding partner B, wherein said first binding partner and said second binding partner form complex AB, wherein said method comprises the following steps: the step of providing at least a first solution comprising molecule B and at least a second solution comprising molecule B; the step of adding a known amount of molecule A to said first solution and adding a known amount of molecule A to said second solution and incubating said first solutions and said second solution after adding said molecule A; the step of measuring the signal of free molecule B in said first solution and said second solution after allowing said first solutions and said second solutions to incubate; and the step of calculating the binding constants for the molecular interaction between said molecule A and said molecule B using the equation K d =[A][B]/[AB] to obtain the binding constants of best fit in said calculation; the method being characterized in that it further comprises: the step of providing a first NSB (non specific binding) solution, wherein said first NSB solution is free of molecule B; the step of measuring the signal of free molecule B in said first NSB solution; wherein the step of calculating the binding constants for the molecular interaction between said molecule A and said molecule B further comprises utilizing the signal measured for free or bound molecule B in said first NSB solution to define the signal from solutions 1 and 2 in the presence of saturating quantity of molecule A. the step of providing at least a first solution comprising molecule B and at least a second solution comprising molecule B; the step of adding a known amount of molecule A to said first solution and adding a known amount of molecule A to said second solution and incubating said first solutions and said second solution after adding said molecule A; the step of measuring the signal of free molecule B in said first solution and said second solution after allowing said first solutions and said second solutions to incubate; and the step of calculating the binding constants for the molecular interaction between said molecule A and said molecule B using the equation K d =[A][B]/[AB] to obtain the binding constants of best fit in said calculation; the method being characterized in that it further comprises: the step of providing a first NSB (non specific binding) solution, wherein said first NSB solution is free of molecule B; the step of measuring the signal of free molecule B in said first NSB solution; wherein the step of calculating the binding constants for the molecular interaction between said molecule A and said molecule B further comprises utilizing the signal measured for free or bound molecule B in said first NSB solution to define the signal from solutions 1 and 2 in the presence of saturating quantity of molecule A.
An implantable medical device , having: - a device housing , comprising a first device housing shell and a second device housing shell , wherein the device housing surrounds an interior , - an electrical component arranged in the interior , the electrical component being a battery or a capacitor, - a mounting frame , which is arranged in the interior and surrounds the electrical component , - wherein the mounting frame comprises at least one clamping structure , and wherein the at least one clamping structure is designed to exert a force onto the electrical component in order to fix the electrical component in the interior of the device housing , and wherein the electrical component is a battery or a capacitor, characterized in that the at least one clamping structure is designed as a rocker, wherein the rocker comprises at least a first arm and a second arm , wherein the first arm and the second arm protrude in different directions from a web formed by the mounting frame . - a device housing , comprising a first device housing shell and a second device housing shell , wherein the device housing surrounds an interior , - an electrical component arranged in the interior , the electrical component being a battery or a capacitor, - a mounting frame , which is arranged in the interior and surrounds the electrical component , - wherein the mounting frame comprises at least one clamping structure , and wherein the at least one clamping structure is designed to exert a force onto the electrical component in order to fix the electrical component in the interior of the device housing , and
Device for lighting in an aquatic medium, comprising: - a printed circuit board comprising a surface, called front surface , - light-emitting means mounted on the front surface of the printed circuit board , - a protective cover arranged to protect the printed circuit board and the light-emitting means , - heat transfer means arranged to perform transfer of the heat produced by the light-emitting means to the aquatic medium, the heat transfer means comprising at least one heat-conducting resin layer presenting a heat exchange surface in direct contact with the aquatic medium, the resin layer being arranged relatively to the printed circuit board to perform transfer of the heat produced by the light-emitting means to the heat exchange surface , the resin layer being shaped with respect to the protective cover to ensure the tightness of the protective cover with the heat exchange surface , the resin layer presenting a direct contact surface with the front surface of the printed circuit board , the device comprising collimators arranged on the front surface of the printed circuit board for collimating the light emitted by the light-emitting means , and the resin layer presents a thickness smaller than the height of the collimators , characterized in that it comprises through holes arranged in the printed circuit board facing the collimators so as to remove the air (A) trapped between the collimators and the printed circuit board . - a printed circuit board comprising a surface, called front surface , - light-emitting means mounted on the front surface of the printed circuit board , - a protective cover arranged to protect the printed circuit board and the light-emitting means , - heat transfer means arranged to perform transfer of the heat produced by the light-emitting means to the aquatic medium, the heat transfer means comprising at least one heat-conducting resin layer presenting a heat exchange surface in direct contact with the aquatic medium, the resin layer being arranged relatively to the printed circuit board to perform transfer of the heat produced by the light-emitting means to the heat exchange surface , the resin layer being shaped with respect to the protective cover to ensure the tightness of the protective cover with the heat exchange surface , the resin layer presenting a direct contact surface with the front surface of the printed circuit board , the device comprising collimators arranged on the front surface of the printed circuit board for collimating the light emitted by the light-emitting means , and the resin layer presents a thickness smaller than the height of the collimators , characterized in that it comprises through holes arranged in the printed circuit board facing the collimators so as to remove the air (A) trapped between the collimators and the printed circuit board .
An apparatus comprising: (a) a housing defining a gap configured to receive a portion of an end effector , having upper and lower jaw portions, of a surgical stapler ; (b) a platform , wherein a portion of the platform is exposed in the gap defined by the housing; (c) a buttress assembly positioned on the platform, wherein the buttress assembly is exposed in the gap defined by the housing; (d) at least one retainer member configured, in a first position, to selectively retain the buttress assembly against the platform, wherein the at least one retainer member is movable to a second position to release the buttress assembly from the platform in response to a clamping action of an end effector positioned in the gap defined by the housing; and (e) an indicator , wherein the indicator is configured to provide indication of a state of the buttress assembly, wherein the indicator is further configured to change state in response to transitioning the upper and lower jaw portions to a closed configuration, wherein the indicator state changes to indicate capture of the buttress assembly by the end effector. (a) a housing defining a gap configured to receive a portion of an end effector , having upper and lower jaw portions, of a surgical stapler ; (b) a platform , wherein a portion of the platform is exposed in the gap defined by the housing; (c) a buttress assembly positioned on the platform, wherein the buttress assembly is exposed in the gap defined by the housing; (d) at least one retainer member configured, in a first position, to selectively retain the buttress assembly against the platform, wherein the at least one retainer member is movable to a second position to release the buttress assembly from the platform in response to a clamping action of an end effector positioned in the gap defined by the housing; and (e) an indicator , wherein the indicator is configured to provide indication of a state of the buttress assembly, wherein the indicator is further configured to change state in response to transitioning the upper and lower jaw portions to a closed configuration, wherein the indicator state changes to indicate capture of the buttress assembly by the end effector.
A method involving a serial interconnection system having a first node (X), a second node (Y), a plurality of calibration nodes (A, B) that are electrically connected in series by the serial interconnection system, and a plurality of connection nodes (A, B) corresponding to the plurality of serially connected calibration nodes, said plurality of connection nodes electrically connected in series by the serial interconnection system, said method characterized in that for each calibration node of the plurality of calibration nodes performing a measurement procedure involving: injecting a corresponding reference signal into that calibration node of the plurality of calibration nodes; and while the corresponding reference signal is being injected into that calibration node of the plurality of calibration nodes, determining a phase summation for that calibration node of the plurality of calibration nodes, said phase summation for that calibration node of the plurality of calibration nodes being a sum of the phases of signals appearing at the first and second nodes; from the determined phase summations for the plurality of calibration nodes, computing phase corrections for each calibration node of the plurality of calibration nodes ; and applying the phase corrections computed for each calibration node of the plurality of calibration nodes to the corresponding plurality of connection nodes . injecting a corresponding reference signal into that calibration node of the plurality of calibration nodes; and while the corresponding reference signal is being injected into that calibration node of the plurality of calibration nodes, determining a phase summation for that calibration node of the plurality of calibration nodes, said phase summation for that calibration node of the plurality of calibration nodes being a sum of the phases of signals appearing at the first and second nodes;
An ultrasonic wireless probe comprising a communication unit configured to exchange various data with the wireless ultrasonic probe over a wireless communication network; a determiner configured to obtain distance information and directional information between the wireless probe and an ultrasonic imaging apparatus calculated using triangulation or radiation pattern information of the wireless communication network, and to determine whether to switch the wireless probe into a low-power mode based on the distance information and the directional information between the wireless probe and the ultrasonic imaging apparatus ; and a probe controller for controlling switching into the low-power mode based on the determined distance information and the determined directional information when the wireless probe is located opposite to the frontal direction of a display of the ultrasonic imaging apparatus. a communication unit configured to exchange various data with the wireless ultrasonic probe over a wireless communication network; a determiner configured to obtain distance information and directional information between the wireless probe and an ultrasonic imaging apparatus calculated using triangulation or radiation pattern information of the wireless communication network, and to determine whether to switch the wireless probe into a low-power mode based on the distance information and the directional information between the wireless probe and the ultrasonic imaging apparatus ; and a probe controller for controlling switching into the low-power mode based on the determined distance information and the determined directional information when the wireless probe is located opposite to the frontal direction of a display of the ultrasonic imaging apparatus.
An antibody, or an antigen-binding fragment thereof, that binds to human complement C5 for use in a method of treating paroxysmal nocturnal hemoglobinuria (PNH) or atypical haemolytic-uremic syndrome (aHUS) in a human, the method comprising: (i) administering to the human an siRNA specific for mRNA encoding human C5 to thereby reduce the C5 concentration in the serum of the human, followed by; (ii) administering to the human the C5 antibody or fragment thereof, wherein a reduced C5 concentration in the serum of the human increases the serum half-life of the C5 antibody or fragment thereof administered to the human. (i) administering to the human an siRNA specific for mRNA encoding human C5 to thereby reduce the C5 concentration in the serum of the human, followed by; (ii) administering to the human the C5 antibody or fragment thereof, wherein a reduced C5 concentration in the serum of the human increases the serum half-life of the C5 antibody or fragment thereof administered to the human.
Storage means for outdoor areas, in particular a garden house or garden shed, comprising: at least two holding compartments being arranged adjacent to each other, each of which has at least one closable opening section , wherein the at least one opening section or the plurality of opening sections jointly belonging to the same holding compartment have a surface that essentially corresponds to a surface of an outer side of this holding compartment , wherein at least one door, flap, slide-in front or roller shutter is assigned to the at least one opening section , to close the at least one opening section , wherein the floor areas of the holding compartments jointly in a horizontal section plane correspond substantially the floor area of the storage means, characterized in that the storage means comprises a rectangular or square floor area having four vertical outer sides, wherein the opening sections are arranged on at least two adjacent vertical outer sides of the storage means. at least two holding compartments being arranged adjacent to each other, each of which has at least one closable opening section , wherein the at least one opening section or the plurality of opening sections jointly belonging to the same holding compartment have a surface that essentially corresponds to a surface of an outer side of this holding compartment , wherein at least one door, flap, slide-in front or roller shutter is assigned to the at least one opening section , to close the at least one opening section , wherein the floor areas of the holding compartments jointly in a horizontal section plane correspond substantially the floor area of the storage means, characterized in that the storage means comprises a rectangular or square floor area having four vertical outer sides, wherein the opening sections are arranged on at least two adjacent vertical outer sides of the storage means.
A method implemented within a system comprising circuitry and program code to perform the operations of: obtaining a first plurality of N streams of information from a first network , transforming the first plurality of N streams of information into a second plurality of M streams of bits, each of the second plurality of M streams of bits being a combination of some or all of the first plurality of N streams of information, sending the second plurality of M streams of bits to M distributed transceiver stations over a second network, the transceiver stations simultaneously sending the second plurality of M streams of bits over wireless links to at least one client device in a way that at least one client device receives at least one of the original first plurality of N streams of information, employing transmit power balancing to enhance channel spatial diversity, wherein a maximum auto-correlation coefficient of a spatial covariance matrix is used as an indication of transmit power imbalance and, wherein thresholds of auto-correlation are defined to select between power balanced and imbalanced systems and those thresholds are obtained based on certain performance criterion and, wherein the auto-correlation is mapped into a transmit gain value and the system uses that value to adaptively adjust the radio frequency (RF) power of the transceiver stations . obtaining a first plurality of N streams of information from a first network , transforming the first plurality of N streams of information into a second plurality of M streams of bits, each of the second plurality of M streams of bits being a combination of some or all of the first plurality of N streams of information, sending the second plurality of M streams of bits to M distributed transceiver stations over a second network, the transceiver stations simultaneously sending the second plurality of M streams of bits over wireless links to at least one client device in a way that at least one client device receives at least one of the original first plurality of N streams of information, employing transmit power balancing to enhance channel spatial diversity, wherein a maximum auto-correlation coefficient of a spatial covariance matrix is used as an indication of transmit power imbalance and, wherein thresholds of auto-correlation are defined to select between power balanced and imbalanced systems and those thresholds are obtained based on certain performance criterion and, wherein the auto-correlation is mapped into a transmit gain value and the system uses that value to adaptively adjust the radio frequency (RF) power of the transceiver stations .
A needle guard for protecting a human or animal from accidental contact with a needle connected to said needle guard , comprising: a mounting base for the needle; a hinge structure connecting the mounting base to a needle shield , the hinge structure being adapted to pivot the needle shield relative to the mounting base from an open position in which the needle shield is separated from the needle, to a closed position in which the needle shield encloses the needle; and a needle shield hinge adjacent to the hinge structure and needle shield , the needle shield hinge being adapted to pivot the needle shield relative to the hinge structure , characterized in that the hinge structure comprises: a spring member connected to the mounting base ; and a spring plate connected to the spring member for cooperating with the needle shield during use with the needle. a mounting base for the needle; a hinge structure connecting the mounting base to a needle shield , the hinge structure being adapted to pivot the needle shield relative to the mounting base from an open position in which the needle shield is separated from the needle, to a closed position in which the needle shield encloses the needle; and a needle shield hinge adjacent to the hinge structure and needle shield , the needle shield hinge being adapted to pivot the needle shield relative to the hinge structure , characterized in that the hinge structure comprises: a spring member connected to the mounting base ; and a spring plate connected to the spring member for cooperating with the needle shield during use with the needle.
A shelf electrical supply , comprising: a bottom cover , a top cover disposed on the bottom cover, positive and negative wires sandwiched between the bottom cover and the top cover and insulated from each other, and positive and negative power contactors sandwiched between the bottom cover and the top cover, the bottom cover comprising a body , protruding holes of the positive and negative contactors alternately disposed at ends of the body, a wire accommodating groove arranged on the body; the positive and negative wires being held in the wire accommodating groove ; the positive and negative power contactors respectively comprising a positive and a negative sleeves , and two superposed positive and negative magnets respectively arranged in the positive and the negative sleeves; the positive and the negative sleeves respectively comprising a positive and a negative protruding portion , a positive and a negative clamping portion respectively electrically connected with the positive and negative wires; the positive and negative clamping portions being located between the bottom cover and the top cover ; two magnets held in the positive and the negative sleeves being mutually exclusive and being located between the positive and negative protruding portions and the top cover ; the positive and negative protruding portions respectively protruding the protruding holes of the positive and negative contactors under the repulsive force of the two positive and negative magnets held in the positive and negative sleeves. the bottom cover comprising a body , protruding holes of the positive and negative contactors alternately disposed at ends of the body, a wire accommodating groove arranged on the body; the positive and negative wires being held in the wire accommodating groove ; the positive and negative power contactors respectively comprising a positive and a negative sleeves , and two superposed positive and negative magnets respectively arranged in the positive and the negative sleeves; the positive and the negative sleeves respectively comprising a positive and a negative protruding portion , a positive and a negative clamping portion respectively electrically connected with the positive and negative wires; the positive and negative clamping portions being located between the bottom cover and the top cover ; two magnets held in the positive and the negative sleeves being mutually exclusive and being located between the positive and negative protruding portions and the top cover ; the positive and negative protruding portions respectively protruding the protruding holes of the positive and negative contactors under the repulsive force of the two positive and negative magnets held in the positive and negative sleeves.
Use of a photocatalytic system comprising at least one poly(heptazine imide) and at least one sulfur source in photocatalytic thiolations or in the oxidative conversion of N-carboxylated hydrazones to oxadiazoles.
Tractor having a loading area and/or a trailer device for at least one trailer, wherein the tractor has a control device for limiting a velocity of the tractor and a ground profile-determining device (10, 11; 24), wherein the ground profile-determining device is configured to determine a current ground profile and to pass on this information to the control device, and the control device is configured to limit the velocity of the tractor to a maximum permissible velocity in accordance with a ground profile determined by the ground profile-determining device (10, 11; 24), characterized in that the ground profile-determining device has an angle sensor (10, 11; 24) for determining the position of the tractor relative to the vertical.