mhurhangee/patent-ind-claim-en huggingface dataset:
A method of delivering a protein component of an RNA-guided endonuclease (RGEN) into a microbial cell, said method comprising: contacting the microbial cell with a composition comprising the protein component of the RNA-guided endonuclease (RGEN) and at least one cell-penetrating peptide (CPP), wherein said protein component and CPP are covalently, or non-covalently, linked to each other in an RGEN protein-CPP complex, and wherein the composition further comprises at least one RNA component that is associated with the protein component of the RGEN, wherein the RNA component comprises a sequence complementary to a target site sequence on a chromosome or episome in the cell, wherein the RGEN can bind to the target site sequence, and optionally cleave one or both DNA strands at the target site sequence, wherein said RGEN protein-CPP complex traverses (i) a cell membrane, or (ii) a cell wall and cell membrane, of the cell, thereby entering the microbial cell. contacting the microbial cell with a composition comprising the protein component of the RNA-guided endonuclease (RGEN) and at least one cell-penetrating peptide (CPP), wherein said protein component and CPP are covalently, or non-covalently, linked to each other in an RGEN protein-CPP complex, and wherein the composition further comprises at least one RNA component that is associated with the protein component of the RGEN, wherein the RNA component comprises a sequence complementary to a target site sequence on a chromosome or episome in the cell, wherein the RGEN can bind to the target site sequence, and optionally cleave one or both DNA strands at the target site sequence, wherein said RGEN protein-CPP complex traverses (i) a cell membrane, or (ii) a cell wall and cell membrane, of the cell, thereby entering the microbial cell.
A control arrangement (20; 20a-20d) for controlling movements of an access member relative to a frame , the control arrangement (20; 20a-20d) comprising: - a base structure ; - a drive member rotatable relative to the base structure about a rotation axis ; - an input member (38; 38a, 38b) arranged to be driven relative to the base structure along an actuation axis by rotation of the drive member about the rotation axis , and arranged to move in a lateral direction with respect to the actuation axis relative to the base structure ; - an output member arranged to be driven by the input member (38; 38a, 38b) relative to the base structure along the actuation axis ; and - an electromagnetic generator arranged to be driven by movement of the output member along the actuation axis to generate electric energy; characterized in that the control arrangement (20; 20a-20d) further comprises: - a force transmitting arrangement (42, 52; 42a, 42b, 52a, 52b; 116) arranged to transmit a relative movement between the input member (38; 38a, 38b) and the output member along the actuation axis to a movement of the input member (38; 38a, 38b) in the lateral direction towards the base structure for frictional braking between the input member (38; 38a, 38b) and the base structure . - a base structure ; - a drive member rotatable relative to the base structure about a rotation axis ; - an input member (38; 38a, 38b) arranged to be driven relative to the base structure along an actuation axis by rotation of the drive member about the rotation axis , and arranged to move in a lateral direction with respect to the actuation axis relative to the base structure ; - an output member arranged to be driven by the input member (38; 38a, 38b) relative to the base structure along the actuation axis ; and - an electromagnetic generator arranged to be driven by movement of the output member along the actuation axis to generate electric energy; - a force transmitting arrangement (42, 52; 42a, 42b, 52a, 52b; 116) arranged to transmit a relative movement between the input member (38; 38a, 38b) and the output member along the actuation axis to a movement of the input member (38; 38a, 38b) in the lateral direction towards the base structure for frictional braking between the input member (38; 38a, 38b) and the base structure .
Method for preparing an application process on an agricultural area (N), comprising the steps of: - determining the quantity of application material required for an application process on an agricultural area (N); and - filling an agricultural application machine with the determined quantity of application material required for the application process; wherein the quantity of application material required for the application process is determined by a method for determining the quantity of application material required for an application process on an agricultural area (N), comprising the steps of: - detecting boundaries of an agricultural area (N); and - determining a quantity of application material required for an application process on the agricultural area (N), wherein, when determining the quantity of application material required for the application process on the agricultural area (N), the boundary application within boundary-proximal regions of the agricultural area (N), which application deviates from the substantially uniform material application within boundary-distal inner regions of the agricultural area (N), is taken into account. - determining the quantity of application material required for an application process on an agricultural area (N); and - filling an agricultural application machine with the determined quantity of application material required for the application process; wherein the quantity of application material required for the application process is determined by a method for determining the quantity of application material required for an application process on an agricultural area (N), comprising the steps of: - detecting boundaries of an agricultural area (N); and - determining a quantity of application material required for an application process on the agricultural area (N), - detecting boundaries of an agricultural area (N); and - determining a quantity of application material required for an application process on the agricultural area (N), wherein, when determining the quantity of application material required for the application process on the agricultural area (N), the boundary application within boundary-proximal regions of the agricultural area (N), which application deviates from the substantially uniform material application within boundary-distal inner regions of the agricultural area (N), is taken into account.
A system for defect detection and photoluminescence measurement of a wafer sample , comprising: a radiation source configured to target radiation to the sample ; an optics assembly positioned above the sample to receive a sample radiation, the sample radiation being radiation which is reflected or scattered by the sample and radiation which is radiated from the sample , the optics assembly configured to collect the sample radiation; a filter module configured to receive the sample radiation collected by the optics assembly , the filter module separating the sample radiation collected by the optics assembly into a first radiation portion and a second radiation portion; a defect detection module configured to receive the first radiation portion from the filter module , the defect detection module configured to detect at least one scatter defect of the sample utilizing the first radiation portion; and a photoluminescence measurement module configured to receive the second radiation portion from the filter module , the photoluminescence measurement module including a photodiode configured to detect an integrated photoluminescence of the sample utilizing the second radiation portion, the photoluminescence measurements module configured to provide a high resolution luminosity map based upon the detected integrated photoluminescence, the defect detection module and the photoluminescence measurement module configured to receive the respective first radiation portion and the second radiation portion substantially simultaneously. a radiation source configured to target radiation to the sample ; an optics assembly positioned above the sample to receive a sample radiation, the sample radiation being radiation which is reflected or scattered by the sample and radiation which is radiated from the sample , the optics assembly configured to collect the sample radiation; a filter module configured to receive the sample radiation collected by the optics assembly , the filter module separating the sample radiation collected by the optics assembly into a first radiation portion and a second radiation portion; a defect detection module configured to receive the first radiation portion from the filter module , the defect detection module configured to detect at least one scatter defect of the sample utilizing the first radiation portion; and a photoluminescence measurement module configured to receive the second radiation portion from the filter module , the photoluminescence measurement module including a photodiode configured to detect an integrated photoluminescence of the sample utilizing the second radiation portion, the photoluminescence measurements module configured to provide a high resolution luminosity map based upon the detected integrated photoluminescence, the defect detection module and the photoluminescence measurement module configured to receive the respective first radiation portion and the second radiation portion substantially simultaneously.
A protein comprising an amino acid sequence selected from the group consisting of: SEQ ID NO:12, and fragments of SEQ ID NO:12 comprising 450 or more amino acids of SEQ ID NO:12.
Electrically conductive laserable varnish comprising - 3-8 wt.% of cellulose ester solution, the content of cellulose ester in the solution being 2-10 wt.%; - 2-10 wt.% of a conductive pigment; - 5-20% wt.% polyester resin; - 5-20 wt.% acrylate resin; - 0.5-10 wt.% magnesium silicate hydrate in powder form; - at least one wetting agent; - at least one solvent. - 3-8 wt.% of cellulose ester solution, the content of cellulose ester in the solution being 2-10 wt.%; - 2-10 wt.% of a conductive pigment; - 5-20% wt.% polyester resin; - 5-20 wt.% acrylate resin; - 0.5-10 wt.% magnesium silicate hydrate in powder form; - at least one wetting agent; - at least one solvent.
A bending action recognition device, comprising a first electrode, a second electrode surrounded by the first electrode, a current detecting unit connected to the first or the second electrode and a plurality of electrical conductors, wherein the first electrode, the second electrode and the electrical conductors are all arranged on the back of a flexible substrate, the first electrode is connected to a source providing a first voltage, the second electrode is connected to a source providing a second voltage, first ends of all the electrical conductors are connected to the first electrode, second ends of the electrical conductors are located in the vicinity of the second electrode, different electrical conductors are located at different positions on the flexible substrate, and different electrical conductors have different resistance values; when a portion of the flexible substrate is bent backward, at least one electrical conductor corresponding to that portion of the flexible substrate gets electrically in contact with the second electrode, and a first current is generated on the first electrode and the second electrode, when different electrical conductors get electrically in contact with the second electrode, the first current has different current values; and the current detecting unit is used for detecting the first current on the first electrode or the second electrode, and the bending action recognition device recognizes bent portion of the flexible substrate according to the current value of the first current detected by the current detecting unit.
Composition attractive to an insect pest of faba bean of the genus Bruchus, in particular Bruchus rufimanus, comprising (a) 15.0% to 25.0% by weight of linalool, (b) 1.0% to 10.0% by weight of estragol, (c) 15.0% to 25.0% by weight of caryophyllene, (d) 5.0% to 20.0% by weight of limonene, (e) 20.0% to 30.0% by weight of cis-3-hexenyl acetate, (f) 5.0% to 20.0% by weight of ocimene, (g) 1.0% to 10.0% by weight of benzaldehyde, and (h) 1.0% to 10.0% by weight of benzyl alcohol, based on the total weight of the mixture made up of (a), (b), (c), (d), (e), (f), (g) and (h). (a) 15.0% to 25.0% by weight of linalool, (b) 1.0% to 10.0% by weight of estragol, (c) 15.0% to 25.0% by weight of caryophyllene, (d) 5.0% to 20.0% by weight of limonene, (e) 20.0% to 30.0% by weight of cis-3-hexenyl acetate, (f) 5.0% to 20.0% by weight of ocimene, (g) 1.0% to 10.0% by weight of benzaldehyde, and (h) 1.0% to 10.0% by weight of benzyl alcohol,
A lubricating composition comprising (i) an oil of lubricating viscosity and (ii) a polyisobutylene-substituted phenol having the formula: where q is from 3 to 10 and comprises the reaction product of a phenol with a polyisobutylene having a number average molecular weight of 300 to 500. (i) an oil of lubricating viscosity and (ii) a polyisobutylene-substituted phenol having the formula: where q is from 3 to 10 and comprises the reaction product of a phenol with a polyisobutylene having a number average molecular weight of 300 to 500.
An industrial process of fabricating a readily dissolvable cartridge complex comprises: (a) preparing an effervescent material readily dissolvable in an aqueous solution; (b) forming at least one segment of a segmental scaffolding from said effervescent material comprising: (I) forming at least on radial partition of said at least one segment of said segmental scaffolding, extending about said longitudinal centerline of said dissolvable cartridge complex; (II) forming a plurality of axial partitions within said at least one segment of said segmental scaffolding, extending transversally to and along said longitudinal centerline of said dissolvable cartridge complex; (III) forming a plurality of compartments formed in-between said axial partitions, in each one of said plurality of said segments of said segmental scaffolding; (c) preparing a payload substance; (d) forming a plurality of structured payload substance pellets; (e) accommodating said structured payload substance pellets in said compartments of said segmental scaffolding; (f) compressing at least one segment of said segmental scaffolding of said readily dissolvable cartridge complex; (g) iteratively forming a plurality of segments of said readily dissolvable cartridge complex separated by said radial partitions. (a) preparing an effervescent material readily dissolvable in an aqueous solution; (b) forming at least one segment of a segmental scaffolding from said effervescent material comprising: (I) forming at least on radial partition of said at least one segment of said segmental scaffolding, extending about said longitudinal centerline of said dissolvable cartridge complex; (II) forming a plurality of axial partitions within said at least one segment of said segmental scaffolding, extending transversally to and along said longitudinal centerline of said dissolvable cartridge complex; (III) forming a plurality of compartments formed in-between said axial partitions, in each one of said plurality of said segments of said segmental scaffolding; (I) forming at least on radial partition of said at least one segment of said segmental scaffolding, extending about said longitudinal centerline of said dissolvable cartridge complex; (II) forming a plurality of axial partitions within said at least one segment of said segmental scaffolding, extending transversally to and along said longitudinal centerline of said dissolvable cartridge complex; (III) forming a plurality of compartments formed in-between said axial partitions, in each one of said plurality of said segments of said segmental scaffolding; (c) preparing a payload substance; (d) forming a plurality of structured payload substance pellets; (e) accommodating said structured payload substance pellets in said compartments of said segmental scaffolding; (f) compressing at least one segment of said segmental scaffolding of said readily dissolvable cartridge complex; (g) iteratively forming a plurality of segments of said readily dissolvable cartridge complex separated by said radial partitions.
A compound of formula (II) for use for treating sickle cell anemia comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula II or a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable composition comprising a compound of formula II or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier wherein: R 11 is selected from the group consisting of H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, C 6 -C 10 aryl, OR 17 , SR 17 ,SOR 17 , SO 2 R 17 , NR 17 R 18 , NCOR 17 , SCOR 17 , COR 17 , OCOR 17 , B(OH) 2 , NO 2 , NHCOR 17 , CN, CHO, hydroxyl C 1 -C 10 alkyl, and halogen, R 12 is selected from the group consisting of H, C 1 -C 2 alkyl, C 3 -C 10 cycloalkyl, NCOR 14 , and SO 2 R 14 , R 13 to R 16 are each independently selected from the group consisting of H, C 1 -C 10 alkyl, halo C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, C 6 -C 10 aryl, heteroaryl, OR 17 , SR 17 , NR 17 R 18 , NCOR 17 , OCOR 17 ,SCOR 17 ,SOR 17 , SO 2 R 17 , SO 2 NR 17 R 18 , CF 3 , and halogen, and R 17 and R 18 are each independently selected from the group consisting of H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, and C 6 -C 10 aryl. R 11 is selected from the group consisting of H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, C 6 -C 10 aryl, OR 17 , SR 17 ,SOR 17 , SO 2 R 17 , NR 17 R 18 , NCOR 17 , SCOR 17 , COR 17 , OCOR 17 , B(OH) 2 , NO 2 , NHCOR 17 , CN, CHO, hydroxyl C 1 -C 10 alkyl, and halogen, R 12 is selected from the group consisting of H, C 1 -C 2 alkyl, C 3 -C 10 cycloalkyl, NCOR 14 , and SO 2 R 14 , R 13 to R 16 are each independently selected from the group consisting of H, C 1 -C 10 alkyl, halo C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, C 6 -C 10 aryl, heteroaryl, OR 17 , SR 17 , NR 17 R 18 , NCOR 17 , OCOR 17 ,SCOR 17 ,SOR 17 , SO 2 R 17 , SO 2 NR 17 R 18 , CF 3 , and halogen, and R 17 and R 18 are each independently selected from the group consisting of H, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 3 -C 10 cycloalkyl, C 3 -C 10 cycloalkenyl, and C 6 -C 10 aryl.
A power headroom information transmitting method in a terminal, the method comprising: receiving a radio resource control, RRC, message indicating to operate in a bundle transmission mode; determining whether to transmit power headroom information associated with a switch of a transmission mode from the bundle transmission mode to a non-bundle transmission mode, if an uplink grant for new transmission is received; and transmitting the power headroom information according to a result of the determining. receiving a radio resource control, RRC, message indicating to operate in a bundle transmission mode; determining whether to transmit power headroom information associated with a switch of a transmission mode from the bundle transmission mode to a non-bundle transmission mode, if an uplink grant for new transmission is received; and transmitting the power headroom information according to a result of the determining.
An apparatus, comprising: an inner catheter defining an inner catheter lumen configured to receive a guide wire ; an outer catheter defining a first lumen terminating at an infusion aperture in a side wall of the outer catheter, the infusion aperture being in fluid communication with the first lumen , the first lumen configured to communicate a therapeutic biologic to the infusion aperture and into one or more target pancreatic vessels, and a second lumen configured to slidably receive at least a portion of the inner catheter ; a first occlusion element coupled to the inner catheter ; and a second occlusion element coupled to the outer catheter , the second occlusion element disposed proximal to the first occlusion element , a distance between the first occlusion element and the second occlusion element being adjustable; characterized in that the apparatus further comprises: a sealing element coupled to the outer catheter and configured to prevent the therapeutic biologic from entering the second lumen of the outer catheter , the infusion aperture being disposed between the second occlusion element and the sealing element . an inner catheter defining an inner catheter lumen configured to receive a guide wire ; an outer catheter defining a first lumen terminating at an infusion aperture in a side wall of the outer catheter, the infusion aperture being in fluid communication with the first lumen , the first lumen configured to communicate a therapeutic biologic to the infusion aperture and into one or more target pancreatic vessels, and a second lumen configured to slidably receive at least a portion of the inner catheter ; a first occlusion element coupled to the inner catheter ; and a second occlusion element coupled to the outer catheter , the second occlusion element disposed proximal to the first occlusion element , a distance between the first occlusion element and the second occlusion element being adjustable; characterized in that the apparatus further comprises: a sealing element coupled to the outer catheter and configured to prevent the therapeutic biologic from entering the second lumen of the outer catheter , the infusion aperture being disposed between the second occlusion element and the sealing element .
A plastering strip arrangement for sealing placement in a joint between two opposite end faces of first and second building components arranged beside one another, in particular aligned with one another, in particular masonry areas or insulating boards, comprising a first plastering strip with an abutment leg for abutment on the end face of the first building component ; and a second plastering strip with an abutment leg for abutment on the end face of the second building component which is opposite to the end face of the first building component ; wherein an expansion strip is attached to one of the two abutment legs , in particular glued to the same; characterized in that a holding means is provided which fixes the two abutment legs to one another, in particular is attached to the rear portions of the abutment legs; the expansion strip is held in a compressed state by a trapping means , and that the expansion strip is designed such that, upon release of the trapping means , it expands and sealingly abuts on the opposite abutment leg . a first plastering strip with an abutment leg for abutment on the end face of the first building component ; and a second plastering strip with an abutment leg for abutment on the end face of the second building component which is opposite to the end face of the first building component ; wherein an expansion strip is attached to one of the two abutment legs , in particular glued to the same; characterized in that a holding means is provided which fixes the two abutment legs to one another, in particular is attached to the rear portions of the abutment legs; the expansion strip is held in a compressed state by a trapping means , and that the expansion strip is designed such that, upon release of the trapping means , it expands and sealingly abuts on the opposite abutment leg .