mhurhangee/patent-ind-claim-en huggingface dataset:
A method of making a syringe comprising: • providing a needle having an outside surface, a delivery outlet at one end, a base at the other end, and an internal passage extending from the base to the delivery outlet; • providing a mold for making a barrel having an interior surface portion defining a lumen and a front passage , the mold comprising a mold core and a mold cavity , the mold core including a needle support projection located at the top of the core where the core contacts the bottom of the needle; • positioning at least a portion of the needle within the mold cavity, with its base abutting the needle support projection of the mold core • injection molding the barrel by injecting moldable material into the mold cavity, forming the portion of the barrel defining the front opening against the portion of the needle outside surface exposed within the mold cavity to join the barrel and the needle; and • shrinking the molding material to put the needle at a location that will be flush with the surface of the syringe barrel. • providing a needle having an outside surface, a delivery outlet at one end, a base at the other end, and an internal passage extending from the base to the delivery outlet; • providing a mold for making a barrel having an interior surface portion defining a lumen and a front passage , the mold comprising a mold core and a mold cavity , the mold core including a needle support projection located at the top of the core where the core contacts the bottom of the needle; • positioning at least a portion of the needle within the mold cavity, with its base abutting the needle support projection of the mold core • injection molding the barrel by injecting moldable material into the mold cavity, forming the portion of the barrel defining the front opening against the portion of the needle outside surface exposed within the mold cavity to join the barrel and the needle; and • shrinking the molding material to put the needle at a location that will be flush with the surface of the syringe barrel.
A nanosuspension comprising (a) a pharmaceutical active ingredient or nutraceutical active ingredient having a solubility of 0.1-1 mg/mL or <0.1 mg/mL in water at 20°C; (b) at least one alginate selected from the group consisting of (i) sodium alginate having a viscosity of 100 mPa·s or less in a 1 % solution in water at 20° C using Brookfield type RV with Brookfield RV spindle 2 and (ii) potassium alginate; and (c) water, wherein the alginate is present in an amount between 0.25 and 5 percent by weight, based upon the weight of said pharmaceutical active ingredient or nutraceutical active ingredient.
A supporting device for furniture shelves for the reversible connection of a shelf to the shoulders of a piece of furniture, wherein the connection is obtained by means of a pin associated with said shelf and configured so as to protrude from the edge (B) of said shelf and be inserted into a corresponding receiving hole formed on said shoulder of said piece of furniture, the device comprising a slide(15,15") with which the pin is integrally associated and a main body with which the slide is slidingly associated, said device being configured for being inserted within the thickness of said shelf and said slide (15,15") being sliding with respect to said main body along a sliding direction (Y) between a first non-operating position in which said pin is not protruding from said main body and intended not to protrude from said shelf , and a second operating position in which said pin is intended to protrude from said shelf outwardly, said supporting device comprising actuation means of said movable engagement means (15,15"), and movement-transmission means (13b,15c,15b,15c") suitable for transforming the movement of said actuation means into the translational movement along the sliding direction (Y) of said slide (15,15"), wherein - the actuation means comprise a cam which is received in an outlet comprised in the slide; - the cam comprising a substantially hollow cylindrical central body , whose central hole is shaped for receiving a maneuvering tool, and having a shaped profile configured for interacting with a shaped internal profile of said outlet of the slide so as to transform the rotational motion of said cam around an axis (X) coinciding with an axis of said shaped central hole of said hollow cylindrical body , in the translational movement of said slide (15,15") in the sliding direction (Y), characterized in that said cam comprises an elongated body having said shaped profile and retention means being provided in form of a receiving groove provided on the rear internal wall of the shaped internal profile of said slide , and suitable for receiving the end of the elongated body of the cam when the cam is completely rotated clockwise to be arranged along the direction of the axis (Y) so that when the end of the elongated body is in the receiving groove the device remains blocked in a withdrawn pin position corresponding to the first non-operating position, even without the user acting on the cam with the tool (U) and also in contrast to the action of any elastic means. - the actuation means comprise a cam which is received in an outlet comprised in the slide; - the cam comprising a substantially hollow cylindrical central body , whose central hole is shaped for receiving a maneuvering tool, and having a shaped profile configured for interacting with a shaped internal profile of said outlet of the slide so as to transform the rotational motion of said cam around an axis (X) coinciding with an axis of said shaped central hole of said hollow cylindrical body , in the translational movement of said slide (15,15") in the sliding direction (Y),
An electronic device comprising: a support; a charge-transporting layer including a charge-transporting material, or a sensitizing-dye electrode layer including a sensitizing dye, where the charge-transporting layer or the sensitizing dye electrode layer is disposed on or above the support; and a metal oxide layer disposed on or above the charge-transporting layer or the sensitizing-dye electrode layer, wherein the metal oxide layer includes p-type semiconductor metal oxide and silica or metal oxide particles, and wherein an amount of the silica or metal oxide particles included in the metal oxide layer is 0.5% by mass or greater but 1.5% by mass or less relative to the metal oxide layer. a support; a charge-transporting layer including a charge-transporting material, or a sensitizing-dye electrode layer including a sensitizing dye, where the charge-transporting layer or the sensitizing dye electrode layer is disposed on or above the support; and a metal oxide layer disposed on or above the charge-transporting layer or the sensitizing-dye electrode layer, wherein the metal oxide layer includes p-type semiconductor metal oxide and silica or metal oxide particles, and wherein an amount of the silica or metal oxide particles included in the metal oxide layer is 0.5% by mass or greater but 1.5% by mass or less relative to the metal oxide layer.
A fastener for connecting two pipe adapters within a casing, the fastener comprising a fastener body having a central bore with a first engagement portion for engagement with a first pipe adapter and a second engagement portion for engagement with a second pipe adapter , wherein the fastener further comprises an outer wall at least partly surrounding and spaced from said fastener body and having a first end connected to the fastener body , the outer wall comprising a fastener flange extending radially in a direction away from said fastener body for overlaying the casing, a portion of the outer wall being deformable in use so as to dampen axial and/or radial movement of the pipe adapters .
An aircraft wing comprising a wing structure and a spoiler movable relative to the wing structure between a stowed configuration and a deployed configuration, wherein the spoiler comprises an actuator configurable between an engaged mode and a disengaged mode, wherein in the engaged mode, the actuator is arranged to restrict movement of the spoiler and/or move the spoiler between the stowed configuration and deployed configuration, and in the disengaged mode, the actuator allows free movement of the spoiler , wherein the actuator is arranged to move the spoiler from the deployed configuration to the stowed configuration.
A computer-implemented method for identifying a song comprising: - providing a set of musical notation information or harmonic progression information for songs, - receiving a real-time audio signal of a user performing on an instrument, - detecting playing activity in successive segments of the user in successive segments from the real-time audio signal, - detecting notes and/or chords from the real-time audio signal, - storing user play history information comprising of information of songs a user has played before, and how often the user has previously played said songs, optionally additionally in relation to the timing when the user has played said songs, - based on the play history information calculating a first probability for at least one song, the method being characterised by : - based on a number of first probabilities for a number of songs and based on the detected playing activity and the detected notes and/or chords, estimating the song that the user is performing, wherein o said estimation comprises calculating a second probability for a number of different songs wherein the second probabilities are defined by the real-time audio signal corresponding with a particular song of the play history combined with first probability associated with said song, and - providing the song the user is performing or information pertaining to the song. - providing a set of musical notation information or harmonic progression information for songs, - receiving a real-time audio signal of a user performing on an instrument, - detecting playing activity in successive segments of the user in successive segments from the real-time audio signal, - detecting notes and/or chords from the real-time audio signal, - storing user play history information comprising of information of songs a user has played before, and how often the user has previously played said songs, optionally additionally in relation to the timing when the user has played said songs, - based on the play history information calculating a first probability for at least one song, - based on a number of first probabilities for a number of songs and based on the detected playing activity and the detected notes and/or chords, estimating the song that the user is performing, wherein o said estimation comprises calculating a second probability for a number of different songs wherein the second probabilities are defined by the real-time audio signal corresponding with a particular song of the play history combined with first probability associated with said song, and o said estimation comprises calculating a second probability for a number of different songs wherein the second probabilities are defined by the real-time audio signal corresponding with a particular song of the play history combined with first probability associated with said song, and - providing the song the user is performing or information pertaining to the song.
A process to synthesize a compound of formula I, comprising reacting a compound of formula II or III with a compound of formula VI
An arc containment device for diverting energy away from an arc flash occurring within an electrical power system, characterized in that the device comprises: an arc source configured to create a second arc flash ; a plasma gun configured and disposed to inject plasma in proximity of the arc source in response to an arc fault signal in an arc flash event within the electrical power system; a shock shield configured to surround the arc source and the plasma gun ; an inner enclosure configured and disposed to house the shock shield ; an outer enclosure configured and disposed to house the inner enclosure ; a first ablative layer disposed on an outer surface of the inner enclosure ; and a second ablative layer disposed on an inner surface of the outer enclosure ; wherein the shock shield comprises an aperture , and the inner enclosure comprises an opening , the aperture and the opening being disposed relative to each other to permit gas flow from a region inside the shock shield to a region outside the inner enclosure ; wherein the inner enclosure and the outer enclosure are spaced apart to form a passageway therebetween, the passageway has vents to expel gas out of the device ; wherein the passageway is disposed between the first and the second ablative layers . an arc source configured to create a second arc flash ; a plasma gun configured and disposed to inject plasma in proximity of the arc source in response to an arc fault signal in an arc flash event within the electrical power system; a shock shield configured to surround the arc source and the plasma gun ; an inner enclosure configured and disposed to house the shock shield ; an outer enclosure configured and disposed to house the inner enclosure ; a first ablative layer disposed on an outer surface of the inner enclosure ; and a second ablative layer disposed on an inner surface of the outer enclosure ; wherein the shock shield comprises an aperture , and the inner enclosure comprises an opening , the aperture and the opening being disposed relative to each other to permit gas flow from a region inside the shock shield to a region outside the inner enclosure ; wherein the inner enclosure and the outer enclosure are spaced apart to form a passageway therebetween, the passageway has vents to expel gas out of the device ; wherein the passageway is disposed between the first and the second ablative layers .
An anti-PD-L1 antibody for use in the treatment of cancer in a subject provided that the subject has been found to have medium or low level of methylation at genomic coordinate hg19 chr9:5449887-5449891 and/or at one or more CpG sites in genomic coordinate hgl9 chr9: 5450934-5451072 in a sample containing cancer cells from the subject, (i) wherein medium level of methylation is between about 20% to about 40% methylation and wherein low level of methylation is less than about 20% methylation, where the methylation level is determined by bisulfite sequencing, (ii) wherein the medium level of methylation is between about 5% to about 60% methylation and wherein low level of methylation is less than about 5% methylation, where the methylation is determined by next-generation bisulfite sequencing, or (iii) wherein medium level of methylation is a beta value between about 0.2 to 0.3 and wherein low level of methylation is a beta value of less than about 0.2, where the methylation level is determined using a methylation chip array. (i) wherein medium level of methylation is between about 20% to about 40% methylation and wherein low level of methylation is less than about 20% methylation, where the methylation level is determined by bisulfite sequencing, (ii) wherein the medium level of methylation is between about 5% to about 60% methylation and wherein low level of methylation is less than about 5% methylation, where the methylation is determined by next-generation bisulfite sequencing, or (iii) wherein medium level of methylation is a beta value between about 0.2 to 0.3 and wherein low level of methylation is a beta value of less than about 0.2, where the methylation level is determined using a methylation chip array.
A terminal-equipped electric wire comprising: an electric wire that comprises: a conductor formed of at least one element wire, and a covering that covers an outer periphery of the conductor; and a compression terminal fixed to an end of the conductor, wherein the at least one element wire is made of a first material comprising aluminum as a main component, wherein at least a part, which contacts the conductor, of the compression terminal is made of a second material comprising aluminum as a main component, wherein the second material is pure aluminum that consists of Al and inevitable impurities, wherein the first material has a tensile strength greater than a tensile strength of the second material, characterised in that the first material is an aluminum alloy that comprises: 0.2 to 1.0% by mass of Fe; 0.01 to 0.10% by mass of Zr; 0.1% by mass or less of Si; 0.01% by mass or less of Cu; 0.01% by mass or less of Mn; 0.01% by mass or less of Mg; 0.01% by mass or less of Zn; 0.01% by mass or less of Ti; 0.01% by mass or less of V; and a remainder comprising Al and inevitable impurities, and wherein the terminal is provided with multiple compressed points along a longitudinal direction of the conductor. an electric wire that comprises: a conductor formed of at least one element wire, and a covering that covers an outer periphery of the conductor; and a compression terminal fixed to an end of the conductor, wherein the at least one element wire is made of a first material comprising aluminum as a main component, a conductor formed of at least one element wire, and a covering that covers an outer periphery of the conductor; and a compression terminal fixed to an end of the conductor, wherein the at least one element wire is made of a first material comprising aluminum as a main component, wherein at least a part, which contacts the conductor, of the compression terminal is made of a second material comprising aluminum as a main component, wherein the second material is pure aluminum that consists of Al and inevitable impurities, wherein the first material has a tensile strength greater than a tensile strength of the second material, characterised in that the first material is an aluminum alloy that comprises: 0.2 to 1.0% by mass of Fe; 0.01 to 0.10% by mass of Zr; 0.1% by mass or less of Si; 0.01% by mass or less of Cu; 0.01% by mass or less of Mn; 0.01% by mass or less of Mg; 0.01% by mass or less of Zn; 0.01% by mass or less of Ti; 0.01% by mass or less of V; and 0.2 to 1.0% by mass of Fe; 0.01 to 0.10% by mass of Zr; 0.1% by mass or less of Si; 0.01% by mass or less of Cu; 0.01% by mass or less of Mn; 0.01% by mass or less of Mg; 0.01% by mass or less of Zn; 0.01% by mass or less of Ti; 0.01% by mass or less of V; and
Valve assembly for a fluid injector comprising - a valve body having a longitudinal axis (L) and comprising a wall which forms a recess that enables a streaming fluid pass the assembly during an operation, - an armature , - a valve needle having a needle tip and - a damping element wherein - the armature and the damping element comprise penetrating first openings respectively, in which the valve needle is arranged, - the armature , the valve needle and the damping element are arranged axially movable in the recess with respect to the longitudinal axis (L) and relative to the valve body , - the damping element is fixed to the valve needle and arranged between the armature and the needle tip with respect to the longitudinal axis (L) to attenuate a movement of the valve needle relative to the valve body during the operation of the assembly , - the damping element is shaped and positioned to generate fluid friction when the valve needle moves relative to the fluid with which the recess is filled during operation of the valve assembly, - the damping element has an upper surface and the armature has a lower surface which face towards each other and which are spaced apart from one another apart from a region where the upper surface of the damping element has a basically ring-shaped protrusion which is engageable with the armature so that it enters into a form-fit connection with the lower surface of the armature , characterised in that the damping element comprises multiple penetrating second openings to enable the fluid to pass through the assembly during the operation. - a valve body having a longitudinal axis (L) and comprising a wall which forms a recess that enables a streaming fluid pass the assembly during an operation, - an armature , - a valve needle having a needle tip and - a damping element - the armature and the damping element comprise penetrating first openings respectively, in which the valve needle is arranged, - the armature , the valve needle and the damping element are arranged axially movable in the recess with respect to the longitudinal axis (L) and relative to the valve body , - the damping element is fixed to the valve needle and arranged between the armature and the needle tip with respect to the longitudinal axis (L) to attenuate a movement of the valve needle relative to the valve body during the operation of the assembly , - the damping element is shaped and positioned to generate fluid friction when the valve needle moves relative to the fluid with which the recess is filled during operation of the valve assembly, - the damping element has an upper surface and the armature has a lower surface which face towards each other and which are spaced apart from one another apart from a region where the upper surface of the damping element has a basically ring-shaped protrusion which is engageable with the armature so that it enters into a form-fit connection with the lower surface of the armature ,
A machine comprising a device for controlling the machine or a process in said machine by detecting the presence or absence of at least one marker in a fluid formulation to be introduced in said machine, said device comprising: - a tube , said tube comprising an inlet and an outlet, said inlet being in fluid communication with a reservoir of said machine for holding said fluid formulation, said outlet being in fluid communication with a dosing unit of said machine for introducing said fluid formulation in said machine , said tube comprising at least one first arm , at least one second arm and at least one connection part , said connection part connecting said at least one first arm and said at least one second arm , whereby said at least one first arm is at least partially upwardly directed away from said connection part and said at least one second arm is at least partially upwardly directed away from said connection part ; - at least one sensor for detecting the presence of said marker in said fluid formulation by detecting a signal caused by said marker in said fluid formulation, said at least one sensor being positioned in said connection part connecting said first and second arm ; - a controller coupled to said at least one sensor for comparing said signal caused by said marker in said fluid formulation with a predetermined range of values; whereby if said signal caused by said marker in said fluid formulation is not within said predetermined range of values said controller gives a signal to said machine to stop the operation of the machine or said process in said machine . - a tube , said tube comprising an inlet and an outlet, said inlet being in fluid communication with a reservoir of said machine for holding said fluid formulation, said outlet being in fluid communication with a dosing unit of said machine for introducing said fluid formulation in said machine , said tube comprising at least one first arm , at least one second arm and at least one connection part , said connection part connecting said at least one first arm and said at least one second arm , whereby said at least one first arm is at least partially upwardly directed away from said connection part and said at least one second arm is at least partially upwardly directed away from said connection part ; - at least one sensor for detecting the presence of said marker in said fluid formulation by detecting a signal caused by said marker in said fluid formulation, said at least one sensor being positioned in said connection part connecting said first and second arm ; - a controller coupled to said at least one sensor for comparing said signal caused by said marker in said fluid formulation with a predetermined range of values; whereby if said signal caused by said marker in said fluid formulation is not within said predetermined range of values said controller gives a signal to said machine to stop the operation of the machine or said process in said machine .