A system for designating and capturing targets of interest on a slide having a biological sample contained thereon, the system comprising: a microscope imaging unit including a microscope having a stage for positioning the slide thereon, and an image capturing apparatus , wherein the image capturing apparatus generates a digital image representation of at least a portion of the biological sample; a visualization unit including a computer having a display screen, the computer having a selection tool installed thereon, the selection tool being adapted to enable a user to select at least one area of interest from the digital image representation; a laser capture microdissection unit adapted to dissect a portion from the biological sample, and a storage medium comprising a remote server that is networked to the microscope imaging unit , the visualization unit and the laser capture microdissection unit , characterized in that the microscope imaging unit stores the digital image representation in a database on the remote server, the visualization unit is remote and separate from the microscope imaging unit and the laser capture microdissection unit and is usable to access and view the digital image representation stored in the database, and wherein a first set of coordinates is generated and stored in the database on the remote server by the visualization unit upon selection of the at least one area of interest, and wherein the first set of coordinates is transformed to a second set of coordinates corresponding to positions on the slide and readable by the laser capture microdissection unit such that the dissected portion of the biological sample corresponds to the at least one area of interest selected from the digital image representation. a microscope imaging unit including a microscope having a stage for positioning the slide thereon, and an image capturing apparatus , wherein the image capturing apparatus generates a digital image representation of at least a portion of the biological sample; a visualization unit including a computer having a display screen, the computer having a selection tool installed thereon, the selection tool being adapted to enable a user to select at least one area of interest from the digital image representation; a laser capture microdissection unit adapted to dissect a portion from the biological sample, and a storage medium comprising a remote server that is networked to the microscope imaging unit , the visualization unit and the laser capture microdissection unit , characterized in that the microscope imaging unit stores the digital image representation in a database on the remote server, the visualization unit is remote and separate from the microscope imaging unit and the laser capture microdissection unit and is usable to access and view the digital image representation stored in the database, and wherein a first set of coordinates is generated and stored in the database on the remote server by the visualization unit upon selection of the at least one area of interest, and wherein the first set of coordinates is transformed to a second set of coordinates corresponding to positions on the slide and readable by the laser capture microdissection unit such that the dissected portion of the biological sample corresponds to the at least one area of interest selected from the digital image representation. <EOS>