A cryotherapeutic system , comprising: a high-pressure line configured to be removably connected to a supply lumen of a cryo-catheter ; a low-pressure line configured to be removably connected to an exhaust lumen of the cryo-catheter ; and a recompression unit operably connected to the high-pressure line and the low-pressure line , the recompression unit configured to increase the pressure of and at least partially condense refrigerant moving from the low-pressure line to the high-pressure line , wherein the high-pressure line , the low-pressure line , and the recompression unit are configured to define a portion of a closed loop when the high-pressure line is operably connected to the supply lumen and the low-pressure line is operably connected to the exhaust lumen , and wherein: the high-pressure line , the low-pressure line , and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line , disconnecting the exhaust lumen from the low-pressure line , or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant. a high-pressure line configured to be removably connected to a supply lumen of a cryo-catheter ; a low-pressure line configured to be removably connected to an exhaust lumen of the cryo-catheter ; and a recompression unit operably connected to the high-pressure line and the low-pressure line , the recompression unit configured to increase the pressure of and at least partially condense refrigerant moving from the low-pressure line to the high-pressure line , wherein the high-pressure line , the low-pressure line , and the recompression unit are configured to define a portion of a closed loop when the high-pressure line is operably connected to the supply lumen and the low-pressure line is operably connected to the exhaust lumen , and wherein: the high-pressure line , the low-pressure line , and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line , disconnecting the exhaust lumen from the low-pressure line , or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant. the high-pressure line , the low-pressure line , and the recompression unit are configured to contain a first volume of refrigerant; and wherein the system further comprises a make-up reservoir configured to contain a second volume of refrigerant sufficient to replace refrigerant loss from the first volume of refrigerant caused by disconnecting the supply lumen from the high-pressure line , disconnecting the exhaust lumen from the low-pressure line , or both, wherein the high-pressure line includes a supply vessel configured to contain liquid refrigerant; and the low-pressure line includes an exhaust vessel configured to contain gaseous refrigerant, and characterized in that the exhaust vessel comprises an inflatable bladder configured to temporarily store refrigerant. <EOS>