mhurhangee/patent-ind-claim-en huggingface dataset:
A process for preparing concentrated recombinant humanized anti-IgE antibody compositions, comprising: (a) a first ultrafiltering of a first antibody preparation to provide a second antibody preparation; (b) a diafiltering of the second antibody preparation to provide a diafiltered intermediate antibody preparation; and (c) a second ultrafiltering of the diafiltered intermediate antibody preparation to provide a third antibody preparation, wherein steps (a), (b), and (c) are carried out at a temperature of 30°C to 50°C; and wherein the antibody is rhuMAb E25. (a) a first ultrafiltering of a first antibody preparation to provide a second antibody preparation; (b) a diafiltering of the second antibody preparation to provide a diafiltered intermediate antibody preparation; and (c) a second ultrafiltering of the diafiltered intermediate antibody preparation to provide a third antibody preparation, wherein steps (a), (b), and (c) are carried out at a temperature of 30°C to 50°C; and wherein the antibody is rhuMAb E25.
A closure for a container , the closure comprising tamper evident means for indicating if the closure has been removed from the container , in which the tamper evident means is provided within the interior of the closure , wherein: the closure comprises a body , at least part of the body is non-opaque, the tamper-evident means is visible through the body , and a part of the tamper-evident means is retained within the interior of the closure upon first opening and a part of the tamper-evident means is retained on the container after first opening, characterised in that the closure includes one or more markings to indicate fill levels and at least part of the tamper-evident means is aligned with a marking after opening. the closure comprises a body , at least part of the body is non-opaque, the tamper-evident means is visible through the body , and a part of the tamper-evident means is retained within the interior of the closure upon first opening and a part of the tamper-evident means is retained on the container after first opening, characterised in that the closure includes one or more markings to indicate fill levels and at least part of the tamper-evident means is aligned with a marking after opening.
A robot system comprising a sticking mechanism configured to clamp and stick at least one adhesive member on an object and a supply mechanism capable of supplying the adhesive member , wherein: the sticking mechanism comprises a robot hand configured to clamp and release the adhesive member and a robot arm configured to move the robot hand , the robot hand comprising at least one clamping unit configured to clamp and release the adhesive member ; the supply mechanism is separate from the sticking mechanism , characterized in that the supply mechanism supplies the adhesive member in a state that the adhesive member is stuck to a cover material , and separates the cover material from the adhesive member by bending the cover material in a direction away from the adhesive member in order to enable the robot hand to clamp the adhesive member in a state that the cover material is separated from the adhesive member , the robot hand comprises a first cylinder mechanism ; the first cylinder mechanism comprises a first cylinder base and a first rod , a projection length of the first rod from the first cylinder base is variable; and the clamping unit is provided on the first rod . the sticking mechanism comprises a robot hand configured to clamp and release the adhesive member and a robot arm configured to move the robot hand , the robot hand comprising at least one clamping unit configured to clamp and release the adhesive member ; the supply mechanism is separate from the sticking mechanism , characterized in that the supply mechanism supplies the adhesive member in a state that the adhesive member is stuck to a cover material , and separates the cover material from the adhesive member by bending the cover material in a direction away from the adhesive member in order to enable the robot hand to clamp the adhesive member in a state that the cover material is separated from the adhesive member , the robot hand comprises a first cylinder mechanism ; the first cylinder mechanism comprises a first cylinder base and a first rod , a projection length of the first rod from the first cylinder base is variable; and the clamping unit is provided on the first rod .
An electric high-precision 2D stage, comprising: a bottom layer stage module , a middle layer stage module , and an upper layer stage module , wherein the bottom layer stage module is connected to the middle layer stage module through an X-axis cross guide rail , the middle layer stage module is connected to the upper layer stage module through a Y-axis cross guide rail , the bottom layer stage module is connected to the middle layer stage module through an X-axis feeding mechanism, the X-axis feeding mechanism comprises an X-axis driving unit and an X-axis flexible lead screw mechanism, the X-axis driving unit is connected to the X-axis flexible lead screw mechanism, the X-axis flexible lead screw mechanism comprises an X-direction lead screw , an X-axis nut block , an X-direction push block , an X-dome mounting connecting block , a ball push rod , and a ball head plunger , the X-direction lead screw is connected to the X-axis driving unit, the X-axis nut block is mounted on the X-direction lead screw, the X-axis nut block is connected to the X-direction push block, an X-direction slot is provided on the X-dome mounting connecting block, the ball push rod and the ball head plunger are mounted on two sides of the X-direction slot, the X-direction push block is inserted in the X-direction slot, two sides of the X-direction push block are in point contact with the ball push rod and the ball head plunger, respectively, the middle layer stage module is connected to the upper layer stage module through a Y-axis feeding mechanism, and the Y-axis feeding mechanism and the X-axis feeding mechanism have a same structure but opposite mounting directions.
A connecting branch for inserting into an elastomer insert for forming a connection device for secondary piping in combination with a transverse opening in main piping, in a shaft or in a wall, wherein the outside of the elastomer insert is adapted to the transverse opening and the inside of the elastomer insert has a conical screwing region, and wherein the connecting branch has an engagement end , a conical middle part with an external thread , a receiving portion and a drive end with extensions and an end edge , characterised in that at least one spring extension is formed on the drive end , with at least one spring element being formed on the spring extension , which elements are formed as a bow-type spring element or as an arcuate spring element , with either two opposing bow-type spring elements flanking a central portion of the spring extension on the edge, or that two arcuate spring elements are formed on a spring extension such that the spring extension has a middle portion which in each case has, located opposite each other on the edge, a free space in the form of an aperture, the central portion protruding upwards approximately perpendicularly from the end edge of the connecting branch .
An electroporation ablation device comprising: a shaft having an elongated body defining a longitudinal axis , the elongated body having a distal end and a proximal end; an electrode assembly disposed on the shaft comprising: a first pair of electrodes comprising a first electrode disposed proximate to the distal end of the elongated body and a second electrode ; a second pair of electrodes disposed adjacent to the first pair of electrodes and comprising a third electrode and a fourth electrode ; wherein the first electrode comprises a first edge portion generally perpendicular to the longitudinal axis ; wherein the second electrode comprises a second edge portion generally perpendicular to the longitudinal axis and a third edge portion generally perpendicular to the longitudinal axis ; wherein the first edge portion is closer to the second edge portion than the third edge portion; wherein a first side view of the first edge portion along the longitudinal axis is rounded at a first corner with a first edge radius; and wherein a second side view of the second edge portion is rounded at a second corner with a second edge radius. a shaft having an elongated body defining a longitudinal axis , the elongated body having a distal end and a proximal end; an electrode assembly disposed on the shaft comprising: a first pair of electrodes comprising a first electrode disposed proximate to the distal end of the elongated body and a second electrode ; a second pair of electrodes disposed adjacent to the first pair of electrodes and comprising a third electrode and a fourth electrode ; a first pair of electrodes comprising a first electrode disposed proximate to the distal end of the elongated body and a second electrode ; a second pair of electrodes disposed adjacent to the first pair of electrodes and comprising a third electrode and a fourth electrode ; wherein the first electrode comprises a first edge portion generally perpendicular to the longitudinal axis ; wherein the second electrode comprises a second edge portion generally perpendicular to the longitudinal axis and a third edge portion generally perpendicular to the longitudinal axis ; wherein the first edge portion is closer to the second edge portion than the third edge portion; wherein a first side view of the first edge portion along the longitudinal axis is rounded at a first corner with a first edge radius; and wherein a second side view of the second edge portion is rounded at a second corner with a second edge radius.
A measurement apparatus (D) configured to measure a position of a mark formed between a first surface and a second surface on a side opposite to the first surface of a substrate , comprising: a stage configured to hold and move the substrate; a first detector configured to detect an image of the mark; a second detector configured to detect a height position of the first surface; and a processor (P) configured to determine an offset amount from the height position of the first surface detected by the second detector, used to set the focus of the first detector to the mark, wherein the processor includes a first mode in which the offset amount is determined based on a first distance set as a distance from the first surface to the mark, characterized in that the processor further includes a second mode in which the offset amount is determined based on a second distance set as a distance from the second surface to the mark and based on the height position of the first surface detected by the second detector. a stage configured to hold and move the substrate; a first detector configured to detect an image of the mark; a second detector configured to detect a height position of the first surface; and a processor (P) configured to determine an offset amount from the height position of the first surface detected by the second detector, used to set the focus of the first detector to the mark, wherein the processor includes a first mode in which the offset amount is determined based on a first distance set as a distance from the first surface to the mark, characterized in that the processor further includes a second mode in which the offset amount is determined based on a second distance set as a distance from the second surface to the mark and based on the height position of the first surface detected by the second detector.
A filter device comprising a filter candle for fastening and sealing fitter fabrics and membrane tubes on a fitter candle, consisting of a central tube, around which a number of perforated support tubes is situated, caracterized in that fastenings between the filter fabric on the membrane tube and the support tube are provided by means of clamping rings , , in the upper part of the filter candle and clamping rings , , in the lower part of the filter candle, and so there are no protruding parts which impede the filter cake as it drops after the end of filtration.
A flap system for driving a leading-edge flap between a retracted position and an extended position, the system comprising: - a leading-edge flap , - an actuator, - a first fixed link , - a second fixed link , - a third fixed link , - a first connecting link , - a second connecting link and - an auxiliary link , wherein the first fixed link comprises a first support joint for rotatably supporting the first fixed link on a first structurally fixed point , wherein the second fixed link comprises a second support joint for rotatably supporting the second fixed link on a second structurally fixed point , wherein the third fixed link comprises a third support joint for rotatably supporting the third fixed link on a third structurally fixed point, wherein the first fixed link comprises a first connecting joint coupled with an end of the first connecting link , which is coupled with a first flap joint at another end, wherein the second fixed link comprises a second connecting joint rotatably coupled with a central region of the first connecting link , wherein the third fixed link comprises a third connecting joint rotatably coupled with an end of the second connecting link , which is coupled with a second flap joint at another end, wherein the second connecting link is coupled with the first fixed link through the auxiliary link , each at positions inside of the respective ends, and wherein the fixed links , the connecting links and the auxiliary link are arranged to actively place the leading-edge flap from a retracted position into an extended position. - a leading-edge flap , - an actuator, - a first fixed link , - a second fixed link , - a third fixed link , - a first connecting link , - a second connecting link and - an auxiliary link ,
A method of bonding a connector to a first object , the method comprising the steps of: - providing the first object and the connector , the connector being separate from the first object , the connector extending between a proximal end and a distal end and comprising a connector body , - Placing the connector relative to the first object so that the distal end is in physical contact with the first object ; - Driving the connector into material of the first object and coupling mechanical vibration into the connector and/or the first object, until the connector extends through a portion of the first object from a proximal side to a distal side thereof, and until at least a flow portion of thermoplastic material becomes flowable and flows relative to the connector and the first object while the connector body remains solid, and - Causing the flow portion of the thermoplastic material to re-solidify, characterized in that - the connector body forms a distally facing punching edge , in that at least the connector comprises a thermoplastic material in a solid state, in that in the step of driving the connector into material of the first object, the flow portion is a portion of the thermoplastic material of the connector , and in that in the step of driving the connector into material of the first object, material of the first object is punched out by the connector body . - providing the first object and the connector , the connector being separate from the first object , the connector extending between a proximal end and a distal end and comprising a connector body , - Placing the connector relative to the first object so that the distal end is in physical contact with the first object ; - Driving the connector into material of the first object and coupling mechanical vibration into the connector and/or the first object, until the connector extends through a portion of the first object from a proximal side to a distal side thereof, and until at least a flow portion of thermoplastic material becomes flowable and flows relative to the connector and the first object while the connector body remains solid, and - Causing the flow portion of the thermoplastic material to re-solidify, characterized in that - the connector body forms a distally facing punching edge , in that at least the connector comprises a thermoplastic material in a solid state, in that in the step of driving the connector into material of the first object, the flow portion is a portion of the thermoplastic material of the connector , and in that in the step of driving the connector into material of the first object, material of the first object is punched out by the connector body .
A method of operating a chromatography column in methods of manufacture for producing anti-IL-12/IL-23p40 antibodies, specific pharmaceutical compositions of the antibodies, and antigen binding fragments thereof, wherein the anti-IL-12/IL-23p40 antibodies comprise amino acid sequences selected from the group consisting of: (i) a heavy chain (HC) comprising the amino acid sequence of SEQ ID NO:10 and a light chain (LC) comprising the amino acid sequence of SEQ ID NO:11; (ii) a heavy chain variable domain amino acid sequence of SEQ ID NO:7 and a light chain variable domain amino acid sequence of SEQ ID NO:8; and (iii) heavy chain CDR amino acid sequences of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3, and light chain CDR amino acid sequences of SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, said method comprising: collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during a first operation of the chromatography column comprising column packing; determining a model gamma cumulative distribution curve based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front using Formula Ia for a rising transition front or Formula Ib for a falling transition front, C = 1 − 1 Γ k γ k V − V i θ or C = 1 Γ k γ k V − V i θ wherein C is column outlet signal for a given V, V is the accumulated flow divided by the column volume, and k, θ, and V i are the shape, scale and offset parameters used to define the curve; calculating a height equivalent theoretical plate (HETP) value for the at least one mobile phase transition front using Formula II and the model gamma cumulative distribution curve parameters of k, θ, and V i , HETP = σ 2 μ 2 L wherein μ = kθ + V i σ = kθ 2 L = column length; and assessing quality of the chromatography column packing based on said calculated HETP value. collecting column outlet signal and accumulated flow parameters at two or more intervals of at least one mobile phase transition front during a first operation of the chromatography column comprising column packing; determining a model gamma cumulative distribution curve based on the collected column outlet signal and accumulated flow parameters for the at least one mobile phase transition front using Formula Ia for a rising transition front or Formula Ib for a falling transition front, C = 1 − 1 Γ k γ k V − V i θ or C = 1 Γ k γ k V − V i θ wherein C is column outlet signal for a given V, V is the accumulated flow divided by the column volume, and k, θ, and V i are the shape, scale and offset parameters used to define the curve; calculating a height equivalent theoretical plate (HETP) value for the at least one mobile phase transition front using Formula II and the model gamma cumulative distribution curve parameters of k, θ, and V i , HETP = σ 2 μ 2 L wherein μ = kθ + V i σ = kθ 2 L = column length; and assessing quality of the chromatography column packing based on said calculated HETP value.
Door for a household appliance , with a first door panel (10 to 13) and at least one second door panel (10 to 13) arranged at a distance therefrom, and with at least one retaining element , which is connected to the two door panels (10 to 13) and retains the position of the door panels (10 to 13) relative to one another, wherein at least one cover element is embodied, which extends into an intermediate space (14 to 16) between the door panels (10 to 13) and parallel to edge sides of the door panels (10 to 13) and covers the intermediate space (14 to 16) between these edge sides at least in sections in the direction of the edge sides , wherein the at least one retaining element on the one hand and the at least one cover element on the other hand are provided as separate components, wherein the at least one cover element is embodied to be elastically deformable in a direction at right angles to the planes of the door panels (10 to 13), wherein the at least one retaining element has encompassing areas encompassing edge sides of the door panels (10 to 13), characterised in that the at least one retaining element has at least one spacer which extends in a freely projecting manner from an encompassing area which encompasses a door panel (10 to 13) on the edge side in the direction of the other encompassing area and in the assembled state rests against the door panel (10 to 13) encompassed by the other encompassing area , and wherein the spacer is an inclined and/or angled bracket, which rests with a curved end region on an interior of the opposing door panel (10 to 13).
A train gateway network node of a wireless telecommunications network, comprising: determining logic operable to determine whether a train carrying a mobile base station providing an associated mobile cell (A, B) is transiting to a destination comprising a station platform encompassed by a destination cell (Z) provided by an associated base station, by detecting proximity of said train to a cell (X) designated as a boundary cell prior to said destination, said boundary cell comprising a macro cell that is located at a point which it is known that the train will pass prior to arriving at the station platform; and neighbour logic operable, in response to said determining logic determining that said train is transiting to said destination, to instruct that a neighbour cell list of at least one of said mobile cell and said destination cell (Z) is updated to indicate that said mobile cell and said destination cell are neighbours. determining logic operable to determine whether a train carrying a mobile base station providing an associated mobile cell (A, B) is transiting to a destination comprising a station platform encompassed by a destination cell (Z) provided by an associated base station, by detecting proximity of said train to a cell (X) designated as a boundary cell prior to said destination, said boundary cell comprising a macro cell that is located at a point which it is known that the train will pass prior to arriving at the station platform; and neighbour logic operable, in response to said determining logic determining that said train is transiting to said destination, to instruct that a neighbour cell list of at least one of said mobile cell and said destination cell (Z) is updated to indicate that said mobile cell and said destination cell are neighbours.