A system , comprising: a handheld device having a sensing surface configured to be placed on a patient's skin, the handheld device including: an ultrasound sensor including an array of ultrasound transducers that are disposed on the sensing surface and placed on the patient's skin, forming a central portion of the sensing surface; an electrocardiogram (EKG) sensor and an auscultation sensor positioned on portions of the sensing surface that extend outwardly from the central portion; and a processor and a memory coupled to the processor , wherein the processor is configured to implement a synchronization module within the handheld device, wherein the ultrasound sensor, the EKG sensor, and the auscultation sensor are configured to simultaneously acquire respective signals of a patient, and the synchronization module is configured to synchronize the signals acquired by two or more of the ultrasound sensor, the EKG sensor, and the auscultation sensor; and a computing device including a memory and a processor , wherein the processor of the computing device is configured to receive and process signals from the ultrasound sensor , the EKG sensor , and the auscultation sensor of the handheld device . a handheld device having a sensing surface configured to be placed on a patient's skin, the handheld device including: an ultrasound sensor including an array of ultrasound transducers that are disposed on the sensing surface and placed on the patient's skin, forming a central portion of the sensing surface; an electrocardiogram (EKG) sensor and an auscultation sensor positioned on portions of the sensing surface that extend outwardly from the central portion; and a processor and a memory coupled to the processor , wherein the processor is configured to implement a synchronization module within the handheld device, wherein the ultrasound sensor, the EKG sensor, and the auscultation sensor are configured to simultaneously acquire respective signals of a patient, and the synchronization module is configured to synchronize the signals acquired by two or more of the ultrasound sensor, the EKG sensor, and the auscultation sensor; and an ultrasound sensor including an array of ultrasound transducers that are disposed on the sensing surface and placed on the patient's skin, forming a central portion of the sensing surface; an electrocardiogram (EKG) sensor and an auscultation sensor positioned on portions of the sensing surface that extend outwardly from the central portion; and a processor and a memory coupled to the processor , wherein the processor is configured to implement a synchronization module within the handheld device, wherein the ultrasound sensor, the EKG sensor, and the auscultation sensor are configured to simultaneously acquire respective signals of a patient, and the synchronization module is configured to synchronize the signals acquired by two or more of the ultrasound sensor, the EKG sensor, and the auscultation sensor; and a computing device including a memory and a processor , wherein the processor of the computing device is configured to receive and process signals from the ultrasound sensor , the EKG sensor , and the auscultation sensor of the handheld device . <EOS>