A compound for use in the increase of insulin sensitivity, treatment of reduced insulin sensitivity and/or for use in the prevention of insulin resistance, wherein said compound is a compound according to Formula I, or pharmaceutically acceptable salt thereof,: wherein: R 1 is selected from the group consisting of hydrogen, -(C 1 -C 8 )alkyl, -(C 1 -C 8 )alkenyl, -(C 1 -C 8 )alkynyl, unsubstituted or substituted -ara(C 1 -C 6 )alkyl, unsubstituted or substituted -heteroara(C 1 -C 6 )alkyl, where the substituents on said substituted ara(C 1 -C 6 )alkyl and substituted heteroara(C 1 -C 6 )alkyl are selected from the group consisting of halogen, -CN, - NO 2 ,- NH 2 , -NH(C 1 -C 6 )alkyl, -N[(C 1 -C 6 )alkyl)] 2 , -OH, halo(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, -SH, thio(C 1 -C 6 )alkyl, -SONH 2 , -SO 2 NH 2 , -SO-(C 1 -C 6 )alkyl, -SO 2 -(C 1 -C 6 )alkyl, -NHSO 2 (C 1 -C 6 )alkyl, and -NHSO 2 NH 2 ; R 2 is selected from the group consisting of hydrogen, -(C 1 -C 8 )alkyl, -(C 1 -C 8 )alkenyl, -(C 1 -C 8 )alkynyl, unsubstituted or substituted -ara(C 1 -C 6 )alkyl, unsubstituted or substituted -heteroara(C 1 -C 6 )alkyl, where the substituents on said substituted ara(C 1 -C 6 )alkyl and substituted heteroara(C 1 -C 6 )alkyl are selected from the group consisting of halogen, -CN, - NO 2 ,- NH 2 , -OH, halo(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, -SH, thio(C 1 -C 6 )alkyl, -SONH 2 , -SO 2 NH 2 , -SO-(C 1 -C 6 )alkyl, -SO 2 -(C 1 -C 6 )alkyl, -NHSO 2 (C 1 -C 6 )alkyl, and -NHSO 2 NH 2 ; R 3 , R 4 , R 7 , R 8 , R 9 , R 10 , R 13 and R 14 are independently selected from the group consisting of hydrogen and -(C 1 -C 6 )alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, -(C 1 -C 6 )alkyl and -OH, provided that both R 5 and R 6 cannot be -OH; R 11 and R 12 are independently selected from the group consisting of hydrogen, -(C 1 -C 6 )alkyl and -OH, provided that both R 11 and R 12 cannot be -OH; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; o is 0, 1, 2, 3 or 4; p is 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; and r is 0, 1, 2, 3 or 4. R 1 is selected from the group consisting of hydrogen, -(C 1 -C 8 )alkyl, -(C 1 -C 8 )alkenyl, -(C 1 -C 8 )alkynyl, unsubstituted or substituted -ara(C 1 -C 6 )alkyl, unsubstituted or substituted -heteroara(C 1 -C 6 )alkyl, where the substituents on said substituted ara(C 1 -C 6 )alkyl and substituted heteroara(C 1 -C 6 )alkyl are selected from the group consisting of halogen, -CN, - NO 2 ,- NH 2 , -NH(C 1 -C 6 )alkyl, -N[(C 1 -C 6 )alkyl)] 2 , -OH, halo(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, -SH, thio(C 1 -C 6 )alkyl, -SONH 2 , -SO 2 NH 2 , -SO-(C 1 -C 6 )alkyl, -SO 2 -(C 1 -C 6 )alkyl, -NHSO 2 (C 1 -C 6 )alkyl, and -NHSO 2 NH 2 ; R 2 is selected from the group consisting of hydrogen, -(C 1 -C 8 )alkyl, -(C 1 -C 8 )alkenyl, -(C 1 -C 8 )alkynyl, unsubstituted or substituted -ara(C 1 -C 6 )alkyl, unsubstituted or substituted -heteroara(C 1 -C 6 )alkyl, where the substituents on said substituted ara(C 1 -C 6 )alkyl and substituted heteroara(C 1 -C 6 )alkyl are selected from the group consisting of halogen, -CN, - NO 2 ,- NH 2 , -OH, halo(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkoxy, -SH, thio(C 1 -C 6 )alkyl, -SONH 2 , -SO 2 NH 2 , -SO-(C 1 -C 6 )alkyl, -SO 2 -(C 1 -C 6 )alkyl, -NHSO 2 (C 1 -C 6 )alkyl, and -NHSO 2 NH 2 ; R 3 , R 4 , R 7 , R 8 , R 9 , R 10 , R 13 and R 14 are independently selected from the group consisting of hydrogen and -(C 1 -C 6 )alkyl; R 5 and R 6 are independently selected from the group consisting of hydrogen, -(C 1 -C 6 )alkyl and -OH, provided that both R 5 and R 6 cannot be -OH; R 11 and R 12 are independently selected from the group consisting of hydrogen, -(C 1 -C 6 )alkyl and -OH, provided that both R 11 and R 12 cannot be -OH; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; o is 0, 1, 2, 3 or 4; p is 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4; and r is 0, 1, 2, 3 or 4. <EOS>