mhurhangee/patent-ind-claim-en huggingface dataset:
A method of predicting the sensitivity of tumor cell growth to inhibition by a Wnt inhibitor, comprising: (a) detecting in a sample of tumor cells from a patient a level of a biomarker, where the biomarker is selected from the group consisting of: (i) sequenced genomic DNA, cDNA or RNA from cancer tissues to detect an inactivation mutation in the RNF43 gene; (ii) RNF43 mRNA expression; (iii) RNF43 protein expression; or (iv) a combination of biomarkers (i) - (iii); (b) comparing the level of the biomarker in the tumor cell sample to a control level of the biomarker selected from the group consisting of: (i) a control level of the biomarker that has been correlated with sensitivity to the Wnt inhibitor; and (ii) a control level of the biomarker that has been correlated with resistance to the Wnt inhibitor; and (c) selecting the patient as being predicted to benefit from therapeutic administration of the Wnt inhibitor, if the patient's tumor has an inactivating RNF43 mutation or the patient tumor has a decrease of expression of RNF43 protein, or has at least a 50% decrease of expression of RNF43 mRNA, indicating that the patient's tumor is likely to be sensitive to a Wnt inhibitor. (a) detecting in a sample of tumor cells from a patient a level of a biomarker, where the biomarker is selected from the group consisting of: (i) sequenced genomic DNA, cDNA or RNA from cancer tissues to detect an inactivation mutation in the RNF43 gene; (ii) RNF43 mRNA expression; (iii) RNF43 protein expression; or (iv) a combination of biomarkers (i) - (iii); (i) sequenced genomic DNA, cDNA or RNA from cancer tissues to detect an inactivation mutation in the RNF43 gene; (ii) RNF43 mRNA expression; (iii) RNF43 protein expression; or (iv) a combination of biomarkers (i) - (iii); (b) comparing the level of the biomarker in the tumor cell sample to a control level of the biomarker selected from the group consisting of: (i) a control level of the biomarker that has been correlated with sensitivity to the Wnt inhibitor; and (ii) a control level of the biomarker that has been correlated with resistance to the Wnt inhibitor; and (i) a control level of the biomarker that has been correlated with sensitivity to the Wnt inhibitor; and (ii) a control level of the biomarker that has been correlated with resistance to the Wnt inhibitor; and (c) selecting the patient as being predicted to benefit from therapeutic administration of the Wnt inhibitor, if the patient's tumor has an inactivating RNF43 mutation or the patient tumor has a decrease of expression of RNF43 protein, or has at least a 50% decrease of expression of RNF43 mRNA, indicating that the patient's tumor is likely to be sensitive to a Wnt inhibitor.
A method of modeling a set of dispersion curves comprising: by a computer system obtaining an acoustic dataset along a well that accesses a hydrocarbon reservoir ; and determining a set of depth windows (120a-f) along the well ; determining a first subset of dispersion curves for a first subset of depth windows (120a,d,f) using a dispersion model; the method being characterized in further comprising initializing a second subset of dispersion curves for a second subset of depth windows (120b,c,e) using a nearest neighbor search of the first subset of dispersion curves; determining slowness-frequency pairs for the second subset of depth windows (120b,c,e) using the acoustic dataset; updating the second subset of dispersion curves using a recursive scanning method, wherein the recursive scanning method comprises: determining a slowness window for a second frequency based, at least in part, on a slowness intercept and a first slowness at a first frequency, and determining a second slowness at the second frequency using a minimum slowness-frequency pair at the second frequency within the slowness window ; and characterizing rock properties near the well based, at least in part, on the first subset of dispersion curves and the second subset of dispersion curves. by a computer system obtaining an acoustic dataset along a well that accesses a hydrocarbon reservoir ; and determining a set of depth windows (120a-f) along the well ; determining a first subset of dispersion curves for a first subset of depth windows (120a,d,f) using a dispersion model; the method being characterized in further comprising initializing a second subset of dispersion curves for a second subset of depth windows (120b,c,e) using a nearest neighbor search of the first subset of dispersion curves; determining slowness-frequency pairs for the second subset of depth windows (120b,c,e) using the acoustic dataset; updating the second subset of dispersion curves using a recursive scanning method, wherein the recursive scanning method comprises: determining a slowness window for a second frequency based, at least in part, on a slowness intercept and a first slowness at a first frequency, and determining a second slowness at the second frequency using a minimum slowness-frequency pair at the second frequency within the slowness window ; and determining a slowness window for a second frequency based, at least in part, on a slowness intercept and a first slowness at a first frequency, and determining a second slowness at the second frequency using a minimum slowness-frequency pair at the second frequency within the slowness window ; and characterizing rock properties near the well based, at least in part, on the first subset of dispersion curves and the second subset of dispersion curves.
Photovoltaic module comprising a plurality of photovoltaic cells and a conductive back side connection layer for connecting positive and negative back side contacts on a back side of the plurality of photovoltaic (PV) cells , characterised in that the back side connection layer comprises a by-pass diode connection path having a predetermined minimal width (w), along an edge direction of two adjacent cells , the two adjacent cells being positioned at an inter-cell distance (s) from each other, the back side connection layer further comprising two isolation scribe lanes adjacent to the by-pass diode connection path , the by-pass diode connection path being positioned in between two contact layer parts of the back side connection layer and separated by the two isolation scribe lanes , wherein edge contacts , which are a subset of the positive and negative back side contacts , on each of the adjacent cells are arranged at a distance (d) from an edge of the respective adjacent cell, wherein the distance d is larger than 0, such that the total distance (2d+s) between a row of edge contacts is larger than or equal to the sum of the predetermined minimal width (w) and a width of the two isolation scribe lanes adjacent to the by-pass diode connection path .
A testing method for an automated driving system, comprising: acquiring (S201) record data of a sensor device, the record data comprising a plurality of frames of data collected by the sensor device of a vehicle, each frame of data comprising a timestamp, and a first frame and a last frame of the record data corresponding to a same vehicle position; and writing (S202) the record data repeatedly to generate test data for testing the automated driving system; playing a same record data repeatedly for a plurality of times and updating the timestamp of each frame of data in the record data in the process of repeated writing, according to a number of times of a current repeated writing and a time duration corresponding to the record data, to make the timestamps of each frame in the repeatedly written record data continuous and position hopping not occur to the generated test data at a repeatedly written connection position. acquiring (S201) record data of a sensor device, the record data comprising a plurality of frames of data collected by the sensor device of a vehicle, each frame of data comprising a timestamp, and a first frame and a last frame of the record data corresponding to a same vehicle position; and writing (S202) the record data repeatedly to generate test data for testing the automated driving system; playing a same record data repeatedly for a plurality of times and updating the timestamp of each frame of data in the record data in the process of repeated writing, according to a number of times of a current repeated writing and a time duration corresponding to the record data, to make the timestamps of each frame in the repeatedly written record data continuous and position hopping not occur to the generated test data at a repeatedly written connection position.
A double stranded ribonucleic acid (RNAi) agent for inhibiting expression of programmed cell death 1 ligand 1 (PD-L1), wherein said RNAi agent comprises a sense strand and an antisense strand, wherein said sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of nucleotides 3221-3243 of the nucleotide sequence of SEQ ID NO:1 and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the complementary portion of the nucleotide sequence of SEQ ID NO:2, wherein all of the nucleotides of said sense strand and all of the nucleotides of said antisense strand comprise nucleotide modifications, and wherein said sense strand is conjugated to an N-acetylgalactosamine (GalNAc) derivative attached at the 3'-terminus. wherein all of the nucleotides of said sense strand and all of the nucleotides of said antisense strand comprise nucleotide modifications, and wherein said sense strand is conjugated to an N-acetylgalactosamine (GalNAc) derivative attached at the 3'-terminus.
A method for stunning animals for slaughter, the method comprising the following steps: a. breaking through the skull of an animal for slaughter with a bolt so that the bolt penetrates the brain of the animal, b. emitting electromagnetic radiation through a radiation channel within the bolt so that the electromagnetic radiation damages the medulla oblongata and/or an area of the brain surrounding it in such a way that signal conduction from the brain through a spinal cord of the animal for slaughter is prevented. a. breaking through the skull of an animal for slaughter with a bolt so that the bolt penetrates the brain of the animal, b. emitting electromagnetic radiation through a radiation channel within the bolt so that the electromagnetic radiation damages the medulla oblongata and/or an area of the brain surrounding it in such a way that signal conduction from the brain through a spinal cord of the animal for slaughter is prevented.
An assembly for a gas turbine engine having an axial centerline , the assembly comprising: a combustor of the gas turbine engine, the combustor comprising a multi-walled structure , the multi-walled structure including a cold wall , a hot wall and a cooling cavity radially relative to the axial centerline between the cold wall and the hot wall ; the cold wall comprising a plurality of cold wall apertures fluidly coupled with the cooling cavity , each of the plurality of cold wall apertures extending radially relative to the axial centerline through the cold wall from a cold wall exterior surface to a cold wall interior surface , and the plurality of cold wall apertures configured to subject the cold wall to a cold wall pressure drop radially relative to the axial centerline across the cold wall ; and the hot wall comprising a plurality of hot wall apertures fluidly coupled with the cooling cavity , each of the plurality of hot wall apertures extending radially relative to the axial centerline through the hot wall from a hot wall interior surface to a hot wall exterior surface , wherein the cooling cavity extends radially relative to the axial centerline between and to the cold wall interior surface and the hot wall interior surface , and a combustion chamber of the combustor is partially formed by the hot wall exterior surface , characterized in that the plurality of hot wall apertures are configured to subject the hot wall to a hot wall pressure drop radially to the axial centerline across the hot wall that is greater than or equal to the cold wall pressure drop. a combustor of the gas turbine engine, the combustor comprising a multi-walled structure , the multi-walled structure including a cold wall , a hot wall and a cooling cavity radially relative to the axial centerline between the cold wall and the hot wall ; the cold wall comprising a plurality of cold wall apertures fluidly coupled with the cooling cavity , each of the plurality of cold wall apertures extending radially relative to the axial centerline through the cold wall from a cold wall exterior surface to a cold wall interior surface , and the plurality of cold wall apertures configured to subject the cold wall to a cold wall pressure drop radially relative to the axial centerline across the cold wall ; and the hot wall comprising a plurality of hot wall apertures fluidly coupled with the cooling cavity , each of the plurality of hot wall apertures extending radially relative to the axial centerline through the hot wall from a hot wall interior surface to a hot wall exterior surface , wherein the cooling cavity extends radially relative to the axial centerline between and to the cold wall interior surface and the hot wall interior surface , and a combustion chamber of the combustor is partially formed by the hot wall exterior surface , characterized in that the plurality of hot wall apertures are configured to subject the hot wall to a hot wall pressure drop radially to the axial centerline across the hot wall that is greater than or equal to the cold wall pressure drop.
A media gateway comprising: a plurality of virtual instantiations of a media session manager function ; a plurality of virtual instantiations of a media processor function ; and a plurality of virtual instantiations of a media session state datastore function , wherein instantiations of the media session manager function, instantiations of the media processor function, and instantiations of the media session state datastore function are instantiated on different virtual machines. a plurality of virtual instantiations of a media session manager function ; a plurality of virtual instantiations of a media processor function ; and a plurality of virtual instantiations of a media session state datastore function , wherein instantiations of the media session manager function, instantiations of the media processor function, and instantiations of the media session state datastore function are instantiated on different virtual machines.
A pressure-limiting device adapted to be installed in a system comprising a first supply line and a second supply line which may comprise pressurized oil and comprising an evacuation and/or a booster line , the limiting device comprising means forming two valves associated respectively with one of the two supply lines and adapted to open in the event of an overpressure above a predetermined threshold on the associated supply line in order to discharge the corresponding overpressure towards the evacuation and/or booster line or towards the other supply line , characterized in that the two valves comprise a common support rod which operates in traction under the stress of at least one spring defining a calibration that corresponds to said predetermined threshold.
A blade outer air seal (BOAS) , comprising: an inner surface configured to contact a core airflow (C) of a gas turbine engine having an axis (X-X'); an outer surface ; at least one rib extending in an axial direction along the outer surface ; and a plurality of warts extending outward from the outer surface ; wherein the at least one rib includes two ribs spaced apart in a circumferential direction; the plurality of warts includes a first plurality of warts located circumferentially between a first rib of the two ribs and a second rib of the two ribs, and a second plurality of warts and a third plurality of warts each located circumferentially outward from the two ribs; and characterised in that each of the plurality of warts has a conical portion and a spherical portion located radially outward from the conical portion . an inner surface configured to contact a core airflow (C) of a gas turbine engine having an axis (X-X'); an outer surface ; at least one rib extending in an axial direction along the outer surface ; and a plurality of warts extending outward from the outer surface ; wherein the at least one rib includes two ribs spaced apart in a circumferential direction; the plurality of warts includes a first plurality of warts located circumferentially between a first rib of the two ribs and a second rib of the two ribs, and a second plurality of warts and a third plurality of warts each located circumferentially outward from the two ribs; and characterised in that each of the plurality of warts has a conical portion and a spherical portion located radially outward from the conical portion .
A method for controlling loads of a wind turbine connected to a power grid, the wind turbine having a nacelle mounted atop the tower , the tower defining an overall length extending from a bottom end to a top end, the method comprising: receiving, via a controller , sensor signals from one or more sensors being indicative of a movement of the tower and/or the nacelle from a reference point, the movement comprising, at least, a tilt and/or a displacement of the tower and/or the nacelle ; generating, via the controller , a deflection profile of the tower along its overall length from the bottom end to the top end based on the sensor signals; determining, via the controller , at least one of a thrust or a tower load of the wind turbine from the deflection profile ; and, implementing, via the controller , a control action for the wind turbine based on the thrust and/or the tower load; and wherein determining at least one of the thrust or the tower load of the wind turbine from the deflection profile further comprises evaluating the deflection profile in a time domain and a frequency domain, wherein evaluating the deflection profile in the time domain allows for determination of translation and rotation of the tilt of the tower and/or the nacelle and evaluating the deflection profile in the frequency domain allows for determination of sources of energy by structural resonant components. receiving, via a controller , sensor signals from one or more sensors being indicative of a movement of the tower and/or the nacelle from a reference point, the movement comprising, at least, a tilt and/or a displacement of the tower and/or the nacelle ; generating, via the controller , a deflection profile of the tower along its overall length from the bottom end to the top end based on the sensor signals; determining, via the controller , at least one of a thrust or a tower load of the wind turbine from the deflection profile ; and, implementing, via the controller , a control action for the wind turbine based on the thrust and/or the tower load;
A composite particle comprising an electrochemically active metal phase, an insulating phase, and a conducting phase, wherein the electrochemically active metal phase comprises silicon; wherein the conducting phase is a silicide conducting phase selected from FeSi, FeSi 2 , CrSi 2 , NiSi 2 , CoSi 2 , TiSi 2 , Cu 3 Si, ZrSi 2 and an iron titanium silicide; wherein the composite particle comprises grains that are less than 50 nanometers in average longest dimension; and wherein the phases are distributed substantially homogeneously throughout the composite particle.
A method for video coding, comprising: determining, by processing circuitry , a process unit size for a decoder-side motion vector refinement, DMVR; enabling, by the processing circuitry , an application of the DMVR on a current block when a size of the current block is smaller than or equal to the process unit size; and disabling, by the processing circuitry , the application of the DMVR on the current block when the size of the current block is larger than the process unit size, wherein disabling the application of the DMVR on the current block when the size of the current block is larger than the process unit size further comprises: partitioning the current block into a plurality of sub-current blocks having a size equal to or smaller than the process unit size; and applying the DMVR on each of the sub-current blocks independently. determining, by processing circuitry , a process unit size for a decoder-side motion vector refinement, DMVR; enabling, by the processing circuitry , an application of the DMVR on a current block when a size of the current block is smaller than or equal to the process unit size; and disabling, by the processing circuitry , the application of the DMVR on the current block when the size of the current block is larger than the process unit size, wherein disabling the application of the DMVR on the current block when the size of the current block is larger than the process unit size further comprises: partitioning the current block into a plurality of sub-current blocks having a size equal to or smaller than the process unit size; and applying the DMVR on each of the sub-current blocks independently. partitioning the current block into a plurality of sub-current blocks having a size equal to or smaller than the process unit size; and applying the DMVR on each of the sub-current blocks independently.
A method of manufacturing an article of footwear , comprising: forming an upper of the article of footwear , comprising forming the upper by depositing thermoplastic elastomer materials using a solid deposition modeling technique; and engaging the upper with a sole structure . forming an upper of the article of footwear , comprising forming the upper by depositing thermoplastic elastomer materials using a solid deposition modeling technique; and engaging the upper with a sole structure .