A vacuum sponge system, comprising: a sponge (no) having an open-pore structure, an outer surface, a proximal end and a distal end , spaced from the proximal end in an axial direction of the sponge (no); a drainage tube disposed at least partially in the sponge (no), wherein the drainage tube is in fluid communication with the sponge (no); wherein the drainage tube is connectable with a vacuum pump such that a pressure generated by the vacuum pump is applicable to the outer surface of the sponge (no) via the drainage tube ; and a delivery member having an outer surface and extending in an axial direction of the sponge (no) and adapted to establish a fluid communication between a region distal from the distal end of the sponge and region proximal from the proximal end of the sponge in a condition where the pressure provided by the vacuum pump via the drainage tube is applied to a vicinity of the outer surface of the delivery member and the outer surface of the sponge , wherein the vacuum sponge system is to be used in gastro-intestinal lumens of human bodies that are a deeper than 10 cm as seen from a body orifice inside a human body, wherein the delivery member is disposed at least partially radially outside of the sponge, such that in use the delivery member is positioned between the outer surface of the sponge and the inner wall of the body lumen, characterized in that in response to a reduced pressure applied to the outer surface of the sponge via the drainage tube , the sponge is configured to adopt the shape of the delivery member to thereby arrive at a sealed transition between the sponge and the inner wall of the body lumen. a sponge (no) having an open-pore structure, an outer surface, a proximal end and a distal end , spaced from the proximal end in an axial direction of the sponge (no); a drainage tube disposed at least partially in the sponge (no), wherein the drainage tube is in fluid communication with the sponge (no); wherein the drainage tube is connectable with a vacuum pump such that a pressure generated by the vacuum pump is applicable to the outer surface of the sponge (no) via the drainage tube ; and a delivery member having an outer surface and extending in an axial direction of the sponge (no) and adapted to establish a fluid communication between a region distal from the distal end of the sponge and region proximal from the proximal end of the sponge in a condition where the pressure provided by the vacuum pump via the drainage tube is applied to a vicinity of the outer surface of the delivery member and the outer surface of the sponge , wherein the vacuum sponge system is to be used in gastro-intestinal lumens of human bodies that are a deeper than 10 cm as seen from a body orifice inside a human body, wherein the delivery member is disposed at least partially radially outside of the sponge, such that in use the delivery member is positioned between the outer surface of the sponge and the inner wall of the body lumen, characterized in that in response to a reduced pressure applied to the outer surface of the sponge via the drainage tube , the sponge is configured to adopt the shape of the delivery member to thereby arrive at a sealed transition between the sponge and the inner wall of the body lumen. <EOS>