A fluid channel coupling system, comprising: containers of fluid and two coupling devices (30A, 30B, 31A, 31B, 50, 51, 89A, 89B, 101, 103; 202, 203; 302, 308; 304, 310; 306, 312; 350, 351; 352, 353; 354, 355; 800A, 800B; 902, 904; 970, 972), each (30A; 101) having two connectors (15A, 16A; 110, 112) that sealingly engage corresponding connectors (15B, 16B; 132, 134) on the other of the coupling devices (30B; 103) and each having a respective body with an internal passage that connects the connectors to a respective common port of the coupling device; each of the coupling device connectors (15A, 16A, 15A, 16B; 110, 112, 132, 134) being in fluid communication with the respective common port such that when the connectors of two coupling devices (30A, 30B; 101, 103) are mutually engaged, the respective ports are in fluid communication with each other and such that when less than all of the connectors (15A, 16A, 15B, 16B; 110, 112, 132, 134) of the two coupling devices (30A, 30B; 101, 103) are mutually engaged, fluid is permitted to flow out from either of the respective ports thereby causing a leak, wherein a first of the coupling devices (30A; 101) has at least one interfering element that interferes with at least one interfering element (32B, 34B; 106A, 106B) of a second of the coupling devices such that both the first coupling device connectors (15A, 16A; 110, 112) cannot be sealingly engaged with both the second coupling device connectors (15B, 16B; 132, 134), and wherein the first or the first and the second coupling device are attached to the containers of fluid via the respective common ports to form access ports for removing fluid from the containers and the contents of the containers of fluid are different, characterized in that the system further comprises a fluid circuit having a coupling device that is compatible with the first and incompatible with the second coupling device attached to the containers of fluid and the containers of fluid include containers of medicament. two coupling devices (30A, 30B, 31A, 31B, 50, 51, 89A, 89B, 101, 103; 202, 203; 302, 308; 304, 310; 306, 312; 350, 351; 352, 353; 354, 355; 800A, 800B; 902, 904; 970, 972), each (30A; 101) having two connectors (15A, 16A; 110, 112) that sealingly engage corresponding connectors (15B, 16B; 132, 134) on the other of the coupling devices (30B; 103) and each having a respective body with an internal passage that connects the connectors to a respective common port of the coupling device; each of the coupling device connectors (15A, 16A, 15A, 16B; 110, 112, 132, 134) being in fluid communication with the respective common port such that when the connectors of two coupling devices (30A, 30B; 101, 103) are mutually engaged, the respective ports are in fluid communication with each other and such that when less than all of the connectors (15A, 16A, 15B, 16B; 110, 112, 132, 134) of the two coupling devices (30A, 30B; 101, 103) are mutually engaged, fluid is permitted to flow out from either of the respective ports thereby causing a leak, wherein a first of the coupling devices (30A; 101) has at least one interfering element that interferes with at least one interfering element (32B, 34B; 106A, 106B) of a second of the coupling devices such that both the first coupling device connectors (15A, 16A; 110, 112) cannot be sealingly engaged with both the second coupling device connectors (15B, 16B; 132, 134), and wherein the first or the first and the second coupling device are attached to the containers of fluid via the respective common ports to form access ports for removing fluid from the containers and the contents of the containers of fluid are different, characterized in that the system further comprises a fluid circuit having a coupling device that is compatible with the first and incompatible with the second coupling device attached to the containers of fluid and the containers of fluid include containers of medicament. <EOS>