A compound, comprising a structure of formula (I): wherein R1 is independently selected from the group consisting of C1-C10 alkyl, C3-C12 cycloalkyl, C1-C2 perfluoroalkyl, heterocyclyl, C1-C2 perfluoroalkoxy, C2-C5 epoxy and deuterium alkyl; R2 is independently selected from the group consisting of C1-C10 alkyl, C3-C12 cycloalkyl, C1-C2 perfluoroalkyl and deuterated alkyl; Y is independently selected from the group consisting of NH-and oxygen atom; and Z is independently selected from substituted benzene ring, substituted pyridine ring, substituted pyrrole ring, substituted imidazole ring, substituted benzofuran, and substituted indole wherein the substituents are selected from the group comprising of halogen, CN, NO 2 , OR, SR, S(O) 2 OR, NRR', C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, (NR)NRR', N(NR)NRR', N(NR)NRR', N(NR)NRR', C(O)(O)R", S 2 R", R', C R', C(O)R", N(R)(CH 2 ) n OH, (CH 2 ) n OR,(CH 2 ) n C(O)NRR', NRS(O) 2 R' wherein n is independently 0-6, including 0 and 6, each R is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl, each R' is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or substituted by C3-C5 cycloalkyl, aryl, heterocyclyl or heteroaryl substituted C-C4 alkyl, each R" is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or substituted by C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl C1-C4 alkyl, each C3-C5 cycloalkyl, aryl, heterocyclyl, heteroaryl and C1-C4 alkyl in each R, R' and R" may be optionally substituted with halogen, CN, C1-C4 alkyl, OH, C1-C4 alkoxy, NH 2 , C1-C4 alkylamino, C1-C4 dialkylamino, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy or 1,2-methylenedioxy. R1 is independently selected from the group consisting of C1-C10 alkyl, C3-C12 cycloalkyl, C1-C2 perfluoroalkyl, heterocyclyl, C1-C2 perfluoroalkoxy, C2-C5 epoxy and deuterium alkyl; R2 is independently selected from the group consisting of C1-C10 alkyl, C3-C12 cycloalkyl, C1-C2 perfluoroalkyl and deuterated alkyl; Y is independently selected from the group consisting of NH-and oxygen atom; and Z is independently selected from substituted benzene ring, substituted pyridine ring, substituted pyrrole ring, substituted imidazole ring, substituted benzofuran, and substituted indole wherein the substituents are selected from the group comprising of halogen, CN, NO 2 , OR, SR, S(O) 2 OR, NRR', C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, (NR)NRR', N(NR)NRR', N(NR)NRR', N(NR)NRR', C(O)(O)R", S 2 R", R', C R', C(O)R", N(R)(CH 2 ) n OH, (CH 2 ) n OR,(CH 2 ) n C(O)NRR', NRS(O) 2 R' wherein n is independently 0-6, including 0 and 6, each R is independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl, each R' is independently hydrogen, alkenyl, alkynyl, C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or substituted by C3-C5 cycloalkyl, aryl, heterocyclyl or heteroaryl substituted C-C4 alkyl, each R" is independently C3-C6 cycloalkyl, aryl, heterocyclyl, heteroaryl, C1-C4 alkyl or substituted by C3-C6 cycloalkyl, aryl, heterocyclyl or heteroaryl C1-C4 alkyl, each C3-C5 cycloalkyl, aryl, heterocyclyl, heteroaryl and C1-C4 alkyl in each R, R' and R" may be optionally substituted with halogen, CN, C1-C4 alkyl, OH, C1-C4 alkoxy, NH 2 , C1-C4 alkylamino, C1-C4 dialkylamino, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy or 1,2-methylenedioxy. <EOS>