mhurhangee/patent-ind-claim-en huggingface dataset:
A modified Bacillus licheniformis cell obtainable from a parental B. licheniformis cell comprising a rghR2 gene encoding a RghR2 protein having 90% sequence identity to SEQ ID NO: 4, wherein the modified cell comprises; a targeting vector configured to delete an 18-nucleotide duplication in the rghR2 gene ( rghR2 dup ) which encodes a repeat of amino acids AAAISR at amino acid positions 38-43 of the RghR2 protein of SEQ ID NO: 4; wherein the deletion of the 18-nt duplication results in a modified rghR2 gene encoding a RghR2 protein having 90% sequence identity to SEQ ID NO: 2; and wherein the modified cell produces an increased amount of a protein of interest relative to the unmodified cell.
An electric submersible pump (ESP) assembly comprising: an electric submersible motor between a thrust chamber and a motor expansion chamber , the motor expansion chamber comprising: a bellows coupled to a releasable bellows anti-movement system , the releasable bellows anti-movement system comprising a heat-activated release and alterable between: an immobilizing position, wherein the releasable anti-movement system prevents concertinaed movement of the bellows in the immobilizing position, and a released position, wherein the bellows is concertinaedly moveable in the released position, and wherein the releasable bellows anti-movement system is in the immobilizing position below a release temperature and in the released position above the release temperature. an immobilizing position, wherein the releasable anti-movement system prevents concertinaed movement of the bellows in the immobilizing position, and a released position, wherein the bellows is concertinaedly moveable in the released position, and wherein the releasable bellows anti-movement system is in the immobilizing position below a release temperature and in the released position above the release temperature.
Photoresistor comprising two electrodes connected by a photosensitive layer of the photoresistor , the photosensitive layer being in physical contact with the electrodes , the photosensitive layer comprising a first face and a second face opposite the first face and intended to be oriented towards the luminous flux, characterized in that the photoresistor comprises two additional layers in contact with the photosensitive layer so as to have an action on the behaviour of the photoresistor with respect to collection of the carriers between the two electrodes in order to improve the sensitivity of the photoresistor , one of these additional layers being formed on one of the faces of the photosensitive layer and being configured so as to increase the resistivity of the photosensitive layer at its interface with said additional layer, and the other of these additional layers being formed on the other face of the photosensitive layer and being configured so as to increase at least locally the conductivity of the photosensitive layer .
A wave generator for a strain wave gearing in which the wave generator is configured to make a flexible externally toothed gear of the strain wave gearing to flex into an ellipsoidal shape and mesh with a rigid internally toothed gear of the strain wave gearing , and to move meshing positions between the both gears in a circumferential direction, the wave generator comprising: a cylindrical rigid plug having a non-circular outer circumferential surface ; a wave-generator bearing fitted on the outer circumferential surface ; and a plug support ring fixed coaxially on an inner circumferential surface of the rigid plug , the rigid plug being formed from an iron-based material; characterized in that the plug support ring is formed from a high-rigidity material that is more rigid than the iron-based material; and in that the high-rigidity material is cemented carbide, ceramics, or composite materials. a cylindrical rigid plug having a non-circular outer circumferential surface ; a wave-generator bearing fitted on the outer circumferential surface ; and a plug support ring fixed coaxially on an inner circumferential surface of the rigid plug , the rigid plug being formed from an iron-based material; characterized in that the plug support ring is formed from a high-rigidity material that is more rigid than the iron-based material; and in that the high-rigidity material is cemented carbide, ceramics, or composite materials.
A clock signal polarity controlling circuit comprising: a first latch comprising a clock input (clk), a data input (D) and an output (Q), wherein the data input (D) is coupled to an output of a clock signal generator , the clock input (clk) is coupled to a reference clock signal (Ref-clk); a second latch comprising a clock input (clk), a data input (D) and an output (Q), wherein the data input (D) is coupled to the output of the first latch , the clock input (clk) is coupled to an inverted of the reference clock signal (Ref-clk); an XOR circuit comprising a first and second inputs and an output (Out), wherein the first and second inputs are coupled to the output of the second latch and the output of the clock signal generator respectively, and wherein a clock signal having a polarity that is controlled by the reference clock signal (Ref-clk) is generated at the output of the XOR circuit , and wherein a frequency of the reference clock signal (Ref-clk) is half of or lower than the frequency of the clock signal. a first latch comprising a clock input (clk), a data input (D) and an output (Q), wherein the data input (D) is coupled to an output of a clock signal generator , the clock input (clk) is coupled to a reference clock signal (Ref-clk); a second latch comprising a clock input (clk), a data input (D) and an output (Q), wherein the data input (D) is coupled to the output of the first latch , the clock input (clk) is coupled to an inverted of the reference clock signal (Ref-clk); an XOR circuit comprising a first and second inputs and an output (Out), wherein the first and second inputs are coupled to the output of the second latch and the output of the clock signal generator respectively, and wherein a clock signal having a polarity that is controlled by the reference clock signal (Ref-clk) is generated at the output of the XOR circuit , and wherein a frequency of the reference clock signal (Ref-clk) is half of or lower than the frequency of the clock signal.
A connecting device for an outlet fitting comprising an installation unit having a housing , at least one feed line interface which can be connected on its input side to a water line, and at least one discharge line interface which can be connected on its output side to a water line leading to the outlet fitting, and a functional unit which is designed separately from the installation unit , which can be connected to the installation unit , and which comprises a line piece which comprises a line piece inlet and a line piece outlet , wherein the line piece inlet is fluidly connectable to the output side of the feed line interface and the line piece outlet is fluidly connectable to the input side of the discharge line interface , and wherein at least one valve is present in the line piece between the line piece inlet and the line piece outlet , with which the flow through the line piece can be controlled, wherein a shut-off member is arranged between the input side of the feed line interface and the output side of the feed line interface , the shut-off member , wherein the shut-off member can assume an open position, in which water can flow through the feed line interface , and a closed position, in which water cannot flow through; characterized in that the shut-off member comprises a securing element , which, in the open position of the shut-off member , engages in the functional unit and which, in the closed position of the shut-off member , does not engage in the functional unit , wherein the engagement of the securing element is such that, in the open position of the shut-off member , the functional unit cannot be separated from the installation unit; in that a filter is provided in the line piece of the functional unit , which filter is secured in the line piece by a filter securing element which can be connected to the functional unit ; and in that , in the open position of the shut-off member , the securing element of the shut-off member engages in the filter securing element and, in the closed position of the shut-off member , does not engage in the filter securing element , wherein the engagement of the securing element is such that, in the open position of the shut-off member , the filter cannot be separated from the functional unit .
A tire comprising a tread portion , wherein the tread portion includes a first shoulder land portion including a first tread edge (Te1), the first shoulder land portion includes a buttress surface outward of the first tread edge (Te1) in a tire axial direction, the first shoulder land portion has a shoulder composite groove crossing the first tread edge (Te1) and open at the buttress surface , and a recess formed on the buttress surface , the recess includes an opening edge on the buttress surface , a bottom surface along the buttress surface , and an inner wall surface connecting the opening edge to the bottom surface , the shoulder composite groove includes, in a transverse cross section thereof, a sipe element having a width not greater than 1.5 mm and extending in a tire radial direction, and a groove element connected to an inner side in the tire radial direction of the sipe element and having a width greater than 1.5 mm, and the groove element is open at the bottom surface of the recess , characterized in that a length in a tire circumferential direction of the recess gradually increases toward an inner side in the tire radial direction, and a minimum length (L4) in the tire circumferential direction of the recess is 0.50 to 0.70 times a maximum length (L3) in the tire circumferential direction of the recess . the tread portion includes a first shoulder land portion including a first tread edge (Te1), the first shoulder land portion includes a buttress surface outward of the first tread edge (Te1) in a tire axial direction, the first shoulder land portion has a shoulder composite groove crossing the first tread edge (Te1) and open at the buttress surface , and a recess formed on the buttress surface , the recess includes an opening edge on the buttress surface , a bottom surface along the buttress surface , and an inner wall surface connecting the opening edge to the bottom surface , the shoulder composite groove includes, in a transverse cross section thereof, a sipe element having a width not greater than 1.5 mm and extending in a tire radial direction, and a groove element connected to an inner side in the tire radial direction of the sipe element and having a width greater than 1.5 mm, and the groove element is open at the bottom surface of the recess , a length in a tire circumferential direction of the recess gradually increases toward an inner side in the tire radial direction, and a minimum length (L4) in the tire circumferential direction of the recess is 0.50 to 0.70 times a maximum length (L3) in the tire circumferential direction of the recess .
A white-box system for authenticating a user-supplied password , comprising: - a password database including a salt value and an authentication value for each user; - a white-box implementation of a symmetric cipher configured to produce an encrypted value by encrypting the user-supplied password using the salt value associated with the user as an encoded secret key; and - a comparator configured to compare the encrypted value with the authentication value associated with the user to verify the user-supplied password. - a password database including a salt value and an authentication value for each user; - a white-box implementation of a symmetric cipher configured to produce an encrypted value by encrypting the user-supplied password using the salt value associated with the user as an encoded secret key; and - a comparator configured to compare the encrypted value with the authentication value associated with the user to verify the user-supplied password.
Light-emitting diode (1; 100) comprising: - a lower layer , at least partially made of a doped semiconductor, - an upper layer , at least partially made of a doped semiconductor, the lower and upper layers having dopings of opposite types, - an emissive structure , that extends between the lower layer and the upper layer and that is suitable to emit a light radiation when an electric current passes through it, - the upper layer being delimited by an upper surface , through which a portion at least of said light radiation exits, - the lower layer being delimited by a lower surface for injecting electric charges, - the upper surface of the upper layer forming a non-planar three-dimensional structure having hollow patterns , said surface being covered by a contact structure made of one or more electrically-conductive materials, the contact structure (10; 110) extending against said surface , conforming to this non-planar surface , - characterised in that , for each of said patterns, an aspect ratio, equal to the extension (h) of said pattern in a direction (Z) perpendicular to said layers , divided by a transverse dimension (D) of said pattern in a plane parallel to said layers , said dimension being representative of the size of the pattern, is greater than or equal to 2. - a lower layer , at least partially made of a doped semiconductor, - an upper layer , at least partially made of a doped semiconductor, the lower and upper layers having dopings of opposite types, - an emissive structure , that extends between the lower layer and the upper layer and that is suitable to emit a light radiation when an electric current passes through it, - the upper layer being delimited by an upper surface , through which a portion at least of said light radiation exits, - the lower layer being delimited by a lower surface for injecting electric charges, - the upper surface of the upper layer forming a non-planar three-dimensional structure having hollow patterns , said surface being covered by a contact structure made of one or more electrically-conductive materials, the contact structure (10; 110) extending against said surface , conforming to this non-planar surface , - characterised in that , for each of said patterns, an aspect ratio, equal to the extension (h) of said pattern in a direction (Z) perpendicular to said layers , divided by a transverse dimension (D) of said pattern in a plane parallel to said layers , said dimension being representative of the size of the pattern, is greater than or equal to 2.
Device for compacting, i.e. in particular for harmonic compacting, of mineral mixtures, in particular concrete mixtures in the production of concrete products of all kinds, or for deep drawing, in particular of sheet metal or plastic blanks, comprising: - a machine frame with a machine head , a machine table and at least two side elements connecting the machine head and the machine table , - a first piston-cylinder arrangement connected to the machine table , whereby the first piston-cylinder arrangement is designed to exert lifting and lowering forces on a mould element which can be filled with mineral mixture, i.e. in particular concrete mixture, or on a mould element onto which a sheet metal or plastic blank can be placed, in order to lift the mould element and cause it to vibrate, - a second piston-cylinder arrangement connected to the machine head , which is characterised in that the second piston-cylinder arrangement is designed to hold a punch which can enter the mould element with a retention force which is equal to or greater than the maximum lifting force of the first piston-cylinder arrangement. - a machine frame with a machine head , a machine table and at least two side elements connecting the machine head and the machine table , - a first piston-cylinder arrangement connected to the machine table , whereby the first piston-cylinder arrangement is designed to exert lifting and lowering forces on a mould element which can be filled with mineral mixture, i.e. in particular concrete mixture, or on a mould element onto which a sheet metal or plastic blank can be placed, in order to lift the mould element and cause it to vibrate, - a second piston-cylinder arrangement connected to the machine head , which is characterised in that the second piston-cylinder arrangement is designed to hold a punch which can enter the mould element with a retention force which is equal to or greater than the maximum lifting force of the first piston-cylinder arrangement.
Closure system for a switchgear cabinet door , including at least one closing rod which is predeterminably movable between a closing position and a release position, wherein a first end of the closing rod is provided, in the closing position for closing the switchgear cabinet door , to engage in an opening of a switchgear cabinet housing , characterised in that the closure system has at least one stiffening profile extending substantially parallel to the closing rod , that the stiffening profile is provided for a fixed-position fastening to a base body of the switchgear cabinet door , that the at least one stiffening profile has at least one closing receptacle , and that the closing rod has at least one closing extension , wherein the at least one closing extension in the closing position forms a form-fitting connection with the at least one closing receptacle and in the release position releases the at least one closing receptacle .
An ophthalmic composition comprising: Chlorhexidine digluconate as a therapeutic active agent in an amount of from 0.05 % w/v - 0.5 % w/v, prednisolone acetate, and a pharmaceutically acceptable carrier. Chlorhexidine digluconate as a therapeutic active agent in an amount of from 0.05 % w/v - 0.5 % w/v, prednisolone acetate, and a pharmaceutically acceptable carrier.
In vitro method for detecting renal disease which comprises: a. Determining at least TRAF3 protein level in peripheral blood mononuclear cells (PBMCs) isolated from blood samples obtained from the patient, b. Wherein if the level determined in step (a) is statistically lower than the level determined in healthy control subjects, this is an indication that the patient is suffering from renal disease. a. Determining at least TRAF3 protein level in peripheral blood mononuclear cells (PBMCs) isolated from blood samples obtained from the patient, b. Wherein if the level determined in step (a) is statistically lower than the level determined in healthy control subjects, this is an indication that the patient is suffering from renal disease.
An in vitro or ex vivo method of introducing double-stranded breaks into a target DNA in a mammalian cell, the method comprising contacting the target DNA with a Type II Clustered Regularly interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system comprising: a. a Cas9 protein with one nuclear localization signal (NLS) added to the C-terminus of the Cas9 protein; and b. a single-chain guide RNA comprising a CRISPR RNA (crRNA) portion fused to a trans-activating crRNA (tracrRNA) portion, wherein the method comprises transfecting the mammalian cell with a nucleic acid encoding the Cas9 protein followed by transfecting the mammalian cell with the single-chain guide RNA. a. a Cas9 protein with one nuclear localization signal (NLS) added to the C-terminus of the Cas9 protein; and b. a single-chain guide RNA comprising a CRISPR RNA (crRNA) portion fused to a trans-activating crRNA (tracrRNA) portion,
A therapeutic hand exercise device comprising: one or more pliant sleeves for receiving one or more digits of a human hand, a chamber provided in at least a dorsal region of the or each pliant sleeve , a liquid inlet to the chamber , a closed reservoir connected to a pump by a conduit for supplying pressurised liquid from the closed reservoir to the or each chamber when the pump is switched on, the or each pliant sleeve being movable between a relaxed state and a stiffened state in which the pliant sleeve forms a substantially rigid elongate member for holding a finger disposed within the sleeve in an extended position, characterised in that a means is provided to disable the liquid pressure by switching off the pump and opening a valve to allow free return of liquid into the reservoir , for allowing passive motion exercise of the hand to occur. one or more pliant sleeves for receiving one or more digits of a human hand, a chamber provided in at least a dorsal region of the or each pliant sleeve , a liquid inlet to the chamber , a closed reservoir connected to a pump by a conduit for supplying pressurised liquid from the closed reservoir to the or each chamber when the pump is switched on, the or each pliant sleeve being movable between a relaxed state and a stiffened state in which the pliant sleeve forms a substantially rigid elongate member for holding a finger disposed within the sleeve in an extended position, characterised in that a means is provided to disable the liquid pressure by switching off the pump and opening a valve to allow free return of liquid into the reservoir , for allowing passive motion exercise of the hand to occur.
A cross-sectional profile for a flat key or the keyway of a cylinder lock, comprising a back surface , a first lateral surface and a second lateral surface , wherein a. the lateral surfaces extend in the vertical direction to the back surface , b. the lateral surfaces are arranged offset to one another by a distance , which optionally varies along their extension, c. the outline of the cross-sectional profile defines a preferably substantially rectangular base profile , d. the lateral surfaces each extend at least in sections along sinusoidal profiling lines , and wherein e. the centerlines of the profiling lines lie within the base profile , characterized in that the centerlines of the profiling lines f. extend at an angle α to the center plane of the base profile , which is preferably approximately 5°, and g. linearly approach one another along their extension from the back surface . a. the lateral surfaces extend in the vertical direction to the back surface , b. the lateral surfaces are arranged offset to one another by a distance , which optionally varies along their extension, c. the outline of the cross-sectional profile defines a preferably substantially rectangular base profile , d. the lateral surfaces each extend at least in sections along sinusoidal profiling lines , and wherein e. the centerlines of the profiling lines lie within the base profile , characterized in that the centerlines of the profiling lines f. extend at an angle α to the center plane of the base profile , which is preferably approximately 5°, and g. linearly approach one another along their extension from the back surface .
A compound of formula (I): wherein R1 is; wherein AA is a peptide bond-linked natural amino acid, or a pharmaceutically acceptable salt thereof, for use in a method of treating depression. wherein R1 is; wherein AA is a peptide bond-linked natural amino acid, or a pharmaceutically acceptable salt thereof, for use in a method of treating depression.
A device for transport of a material across a biological barrier of a subject, comprising a plurality of microneedles each having a base end and a tip, a substrate to which the base ends of the microneedles are attached or integrated and nanoparticles, characterised in that the nanoparticles are acid-degradable nanoparticles, wherein the acid-degradable nanoparticles encapsulate an immunotherapeutic agent and a pH altering agent.