mhurhangee/patent-ind-claim-en huggingface dataset:
A highly wear-resistant tile , comprising a tile body ; in an upper portion of the tile body , there are two or more first holes (2, 6-1) extending downward, central axes of which are in a same plane; in the middle of a lower portion of the tile body , there is one reference hole (3, 6-2) extending upward, and one or more groups of second holes (4, 6-3) are formed around the reference hole (3, 6-2), with a centerline of each group of second holes (4, 6-3) being in a same plane as a centerline of the reference hole (3, 6-2); in a horizontal direction of the tile body , by one or more transverse cavities , all the first holes (2, 6-1), the reference hole (3, 6-2) and the second holes (4, 6-3) are integrally connected to form a hollow chamber, so that rubber may flow from the first holes (2, 6-1) toward the reference hole (3, 6-2) and the second holes (4, 6-3) through the hollow chamber and may finally fill the whole hollow chamber; characterized in that : the transverse cavity arranged on the tile body runs through the horizontal direction of the whole tile body ; upper ends of the first holes (2, 6-1) being of a chamfered structure; both a lower end of the reference hole (3, 6-2) and a lower end of the second holes (4, 6-3) being of a chamfered structure; and on the tile body , an edge formed when a face meets with another face is of a chamfered structure having a chamfer of greater than 0.02 mm.
Method in a user equipment for requesting a status report from a node , the user equipment and the node both being comprised within a wireless communication network , the status report comprising positive and/or negative acknowledgement of data sent from the user equipment to be received by the node , wherein the method comprises the steps of: initializing a protocol data unit, PDU, counter and a byte counter; counting, by the PDU counter, PDUs being transmitted from the user equipment to the node; counting, by the byte counter, bytes being transmitted from the user equipment to the node; and triggering a poll to request an RLC protocol status report from the node and resetting both the PDU counter and the byte counter when: i) the PDU counter becomes equal to or greater than a predetermined PDU threshold, or ii) the byte counter becomes equal to or greater than a predetermined byte threshold, wherein the PDU threshold and the byte threshold are configured by Radio Resource Control. initializing a protocol data unit, PDU, counter and a byte counter; counting, by the PDU counter, PDUs being transmitted from the user equipment to the node; counting, by the byte counter, bytes being transmitted from the user equipment to the node; and triggering a poll to request an RLC protocol status report from the node and resetting both the PDU counter and the byte counter when: i) the PDU counter becomes equal to or greater than a predetermined PDU threshold, or ii) the byte counter becomes equal to or greater than a predetermined byte threshold, i) the PDU counter becomes equal to or greater than a predetermined PDU threshold, or ii) the byte counter becomes equal to or greater than a predetermined byte threshold, wherein the PDU threshold and the byte threshold are configured by Radio Resource Control.
Therapeutic agent for use in the treatment of neurodegenerative diseases associated with abnormalities of MAPT gene encoded protein tau, wherein said therapeutic agent comprises one or more siRNAs targeting MAPT gene exon 10, wherein the one or more siRNAs are selected from a double strand RNA composed of a sense strand comprising a base sequence set forth in SEQ ID No.: 2, 4, or 6, and an antisense strand comprising a sequence complementary thereto, which optionally has an overhang at the terminal of the sense strand and/or antisense strand.
A thermal cycling apparatus comprising: a mounting wall partially defining a chamber for thermally cycling biological samples, the mounting wall having a first mounting surface opposing a second mounting surface ; a sample interfacing wall transversely extending from the second mounting surface , the sample interfacing wall supporting a planar interface accessible from the first mounting surface , the sample interfacing wall having a first heating element and a second heating element on opposing sides of the planar interface ; a first air source (216a,302a,) having an exit arranged to direct air at the first heating element; a second air source having an exit arranged to direct air away from the first heating element; a fourth air source having an exit arranged to direct air at the second heating element; and a third air source having an exit arranged to direct air away from at the second heating element. a mounting wall partially defining a chamber for thermally cycling biological samples, the mounting wall having a first mounting surface opposing a second mounting surface ; a sample interfacing wall transversely extending from the second mounting surface , the sample interfacing wall supporting a planar interface accessible from the first mounting surface , the sample interfacing wall having a first heating element and a second heating element on opposing sides of the planar interface ; a first air source (216a,302a,) having an exit arranged to direct air at the first heating element; a second air source having an exit arranged to direct air away from the first heating element; a fourth air source having an exit arranged to direct air at the second heating element; and a third air source having an exit arranged to direct air away from at the second heating element.
A cassette for an IV pump comprising: an interface element having a first position and a second position, a first and a second pumping chamber each having a volume and each coupled to the interface element such that the volume of the first pumping chamber is increasing while the volume of the second pumping chamber is decreasing as the interface element moves from the first position to the second position and the volume of the first pumping chamber is decreasing while the volume of the second pumping chamber is increasing as the interface element moves from the second position to the first position, the cassette being characterized in that the interface element comprises a slot having a length oriented perpendicular to the direction of linear motion of the interface element between the first and second positions; the interface element configured to be driven from the first position to the second position and back to the first position by unidirectional rotary motion of a driving element from an IV pump configured to use the cassette , the driving element having an axis of rotation and comprising a drive pin that is parallel to and offset from the axis of rotation ; the interface element being configured such that the drive pin fits into the slot and slides along a portion of the length of the slot as the driving element rotates . an interface element having a first position and a second position, a first and a second pumping chamber each having a volume and each coupled to the interface element such that the volume of the first pumping chamber is increasing while the volume of the second pumping chamber is decreasing as the interface element moves from the first position to the second position and the volume of the first pumping chamber is decreasing while the volume of the second pumping chamber is increasing as the interface element moves from the second position to the first position, the cassette being characterized in that the interface element comprises a slot having a length oriented perpendicular to the direction of linear motion of the interface element between the first and second positions; the interface element configured to be driven from the first position to the second position and back to the first position by unidirectional rotary motion of a driving element from an IV pump configured to use the cassette , the driving element having an axis of rotation and comprising a drive pin that is parallel to and offset from the axis of rotation ; the interface element being configured such that the drive pin fits into the slot and slides along a portion of the length of the slot as the driving element rotates .
A storage container including: a container body defining an accommodating space that has a top opening ; a lid removably disposed on said container body , and having two covering sections that cooperatively cover said opening , each one of said covering sections being independently operable to uncover a part of said opening ; and a dividing member removably disposed in said accommodating space for dividing said accommodating space into two compartments ; wherein said dividing member is configured as a plate, characterized in that said dividing member has two plate sections that are connected to each other such that said dividing member is foldable in a manner that said plate sections overlap each other, said dividing member being displaceable between a first position, where said dividing member extends horizontally in said accommodating space such that said compartments are respectively formed on top and bottom sides of said dividing member , and a second position, where said dividing member is folded and is vertically disposed in said accommodating space such that said compartments are respectively formed on two lateral sides of said dividing member . a container body defining an accommodating space that has a top opening ; a lid removably disposed on said container body , and having two covering sections that cooperatively cover said opening , each one of said covering sections being independently operable to uncover a part of said opening ; and a dividing member removably disposed in said accommodating space for dividing said accommodating space into two compartments ; wherein said dividing member is configured as a plate, characterized in that said dividing member has two plate sections that are connected to each other such that said dividing member is foldable in a manner that said plate sections overlap each other, said dividing member being displaceable between a first position, where said dividing member extends horizontally in said accommodating space such that said compartments are respectively formed on top and bottom sides of said dividing member , and a second position, where said dividing member is folded and is vertically disposed in said accommodating space such that said compartments are respectively formed on two lateral sides of said dividing member .
A non-woven sheet extending in a longitudinal direction (X1) and a lateral direction (Y1) orthogonal to the longitudinal direction (X1), said sheet comprising: - at least one zone of reinforcement in which fibers and/or filaments constituting the sheet are bonded together in a reinforcing pattern comprising a plurality of geometric shapes , the zone of reinforcement extending over the entire length (L) of the sheet measured in the longitudinal direction (X1), and over a width (l1, l2) strictly less than the width (l) of the sheet measured in the lateral direction (Y1); and - at least one non-reinforced zone ; the elongation of the reinforced zone under the effect of a given force exerted in the longitudinal direction (X1) being less than the elongation of the non-reinforced zone under the effect of the same force, the geometric shapes of the reinforcing pattern being discrete elements, and the geometric shapes of the reinforcing pattern in each zone of reinforcement being arranged in such a manner that any straight line (D1) extending in the lateral direction (Y1) of the sheet intersects at least one of said shapes . - at least one zone of reinforcement in which fibers and/or filaments constituting the sheet are bonded together in a reinforcing pattern comprising a plurality of geometric shapes , the zone of reinforcement extending over the entire length (L) of the sheet measured in the longitudinal direction (X1), and over a width (l1, l2) strictly less than the width (l) of the sheet measured in the lateral direction (Y1); and - at least one non-reinforced zone ; the elongation of the reinforced zone under the effect of a given force exerted in the longitudinal direction (X1) being less than the elongation of the non-reinforced zone under the effect of the same force,
A system for inducible expression of an adapter in immune cells comprising a) an inducible gene expression system comprising I) a first nucleic acid comprising an inducible promoter operably linked to a second nucleic acid II) said second nucleic acid encoding an adapter comprising i) a first (poly)peptide, wherein said first (poly)peptide comprises an antigen binding domain that binds specifically to an antigen, ii) a second (poly)peptide, wherein said second (poly)peptide binds to an antigen binding domain of a chimeric antigen receptor (CAR), b) a third nucleic acid encoding said CAR specific for said second polypeptide of said adapter, wherein said CAR comprises i) said antigen binding domain specific for said second (poly)peptide of said adapter ii) a transmembrane domain iii) an intracellular signaling domain. a) an inducible gene expression system comprising I) a first nucleic acid comprising an inducible promoter operably linked to a second nucleic acid II) said second nucleic acid encoding an adapter comprising i) a first (poly)peptide, wherein said first (poly)peptide comprises an antigen binding domain that binds specifically to an antigen, ii) a second (poly)peptide, wherein said second (poly)peptide binds to an antigen binding domain of a chimeric antigen receptor (CAR), I) a first nucleic acid comprising an inducible promoter operably linked to a second nucleic acid II) said second nucleic acid encoding an adapter comprising i) a first (poly)peptide, wherein said first (poly)peptide comprises an antigen binding domain that binds specifically to an antigen, ii) a second (poly)peptide, wherein said second (poly)peptide binds to an antigen binding domain of a chimeric antigen receptor (CAR), i) a first (poly)peptide, wherein said first (poly)peptide comprises an antigen binding domain that binds specifically to an antigen, ii) a second (poly)peptide, wherein said second (poly)peptide binds to an antigen binding domain of a chimeric antigen receptor (CAR), b) a third nucleic acid encoding said CAR specific for said second polypeptide of said adapter, wherein said CAR comprises i) said antigen binding domain specific for said second (poly)peptide of said adapter ii) a transmembrane domain iii) an intracellular signaling domain. i) said antigen binding domain specific for said second (poly)peptide of said adapter ii) a transmembrane domain iii) an intracellular signaling domain.
Anti-collision system intended to equip a construction machine including a front (Av), a rear (Ar), a work tool and an operator cab in which there is a seat for the operator and which provides the latter with a field of vision in front of the operator cab which, in top view, is delimited by two straight lines meeting at the seat so as to form a first angle, so-called operator's field of view angle, the work tool being present in the operator's field of view and the construction machine being movable in the front-rear axis, so-called axis of travel, the anti-collision system including: - obstacle detection means configured to detect the presence of an obstacle in an obstacle detection area and its distance from the obstacle detection means ; - audible warning means configured to emit an audible warning in the operator cab ; and - processing means in operative communication with the obstacle detection means and the audible warning means and configured to cause the audible warning means to emit an audible warning in the event of detection, by the obstacle detection means , of an obstacle in the obstacle detection area, the anti-collision system being characterised in that it further includes acquisition means configured to acquire the direction of travel, along the axis of travel, and the speed of the construction machine and connection means configured to removably mount the obstacle detection means on the construction machine such that once mounted on the construction machine , the obstacle detection means are capable of detecting the presence of an obstacle in an obstacle detection area formed by a first detection region, so-called rear region, which is located rearward of the operator cab , and two second detection regions, so-called side regions, which are located on both lateral sides of the operator cab , the processing means also being in operative communication with the acquisition means and configured to cause the audible warning means to emit an audible warning only in the event that the processing means determines that a detected obstacle presents a risk of collision meeting a warning condition defined as a function of the direction of travel and the speed of the construction machine that have been acquired by the acquisition means . - obstacle detection means configured to detect the presence of an obstacle in an obstacle detection area and its distance from the obstacle detection means ; - audible warning means configured to emit an audible warning in the operator cab ; and - processing means in operative communication with the obstacle detection means and the audible warning means and configured to cause the audible warning means to emit an audible warning in the event of detection, by the obstacle detection means , of an obstacle in the obstacle detection area,
A shaving razor comprising: a handle; a power source residing within the handle; a shaving head containing at least two razor blades each having a cutting edge disposed within a single cutting plane, at least two of the blades moveably coupled within the shaving head so that each movable blade can be driven to translate laterally within a respective zone of motion; and an actuator coupled to the power source, the actuator to apply a force that drives the movable blades to reciprocate within the zone of motion, characterized in that at least two adjacent blades translate in opposite directions within their respective zones of motion. a handle; a power source residing within the handle; a shaving head containing at least two razor blades each having a cutting edge disposed within a single cutting plane, at least two of the blades moveably coupled within the shaving head so that each movable blade can be driven to translate laterally within a respective zone of motion; and an actuator coupled to the power source, the actuator to apply a force that drives the movable blades to reciprocate within the zone of motion, characterized in that at least two adjacent blades translate in opposite directions within their respective zones of motion.
An apparatus comprising: a multi-master serial Inter Integrated Circuit I 2 C computer bus having a bus arbitration protocol for arbitrating use of the bus; a first master coupled to the bus; a second master coupled to the bus; a slave device coupled to the bus; a first I/O line from the first master going to the second master and the slave device, wherein the first I/O line is external to the bus; and a second I/O line from the second master going to the first master and the slave device, wherein the second I/O line is external to the bus, wherein the bus arbitration protocol for arbitrating use of the bus restricts the masters to a single transaction, comprising a single read command, a single write command, or a single combined format command between a START marker and a STOP marker, each time either master becomes a bus master, and wherein the first master is adapted to use the I/O lines to signal to the second master to not become a bus master by pulling the first or second I/O line from an idle state to a logic state that indicates that the first master is accessing a slave and the second master is adapted to back off for a delay period and then to check if a maximum retry limit has been exceeded thereby providing the ability for the first master to perform multiple transactions without being interrupted by the second master. a multi-master serial Inter Integrated Circuit I 2 C computer bus having a bus arbitration protocol for arbitrating use of the bus; a first master coupled to the bus; a second master coupled to the bus; a slave device coupled to the bus; a first I/O line from the first master going to the second master and the slave device, wherein the first I/O line is external to the bus; and a second I/O line from the second master going to the first master and the slave device, wherein the second I/O line is external to the bus, wherein the bus arbitration protocol for arbitrating use of the bus restricts the masters to a single transaction, comprising a single read command, a single write command, or a single combined format command between a START marker and a STOP marker, each time either master becomes a bus master, and wherein the first master is adapted to use the I/O lines to signal to the second master to not become a bus master by pulling the first or second I/O line from an idle state to a logic state that indicates that the first master is accessing a slave and the second master is adapted to back off for a delay period and then to check if a maximum retry limit has been exceeded thereby providing the ability for the first master to perform multiple transactions without being interrupted by the second master.
A compound of formula (I) wherein -- A is a 5-7 membered nitrogen-containing heterocyclyl optionally substituted with one oxo group; -- each R is C 1-6 alkyl, optionally substituted by one or more, identical or different R b1 and/or R c1 ; each R b1 is independently selected from among -OR c1 and -C(O)OR c1 ; each R c1 independently of one another is selected from among hydrogen, C 1-6 alkyl, 3-10 membered heterocyclyl and C 1-6 alkyl substituted with a 3-10 membered heterocyclyl; -- q denotes the number 0, 1 or 2; or a salt thereof. -- A is a 5-7 membered nitrogen-containing heterocyclyl optionally substituted with one oxo group; -- each R is C 1-6 alkyl, optionally substituted by one or more, identical or different R b1 and/or R c1 ; each R b1 is independently selected from among -OR c1 and -C(O)OR c1 ; each R c1 independently of one another is selected from among hydrogen, C 1-6 alkyl, 3-10 membered heterocyclyl and C 1-6 alkyl substituted with a 3-10 membered heterocyclyl; each R b1 is independently selected from among -OR c1 and -C(O)OR c1 ; each R c1 independently of one another is selected from among hydrogen, C 1-6 alkyl, 3-10 membered heterocyclyl and C 1-6 alkyl substituted with a 3-10 membered heterocyclyl; -- q denotes the number 0, 1 or 2;