A method for handling wastewater in a healthcare facility, such as a hospital, said wastewater comprising blackwater from patient toilets, blackwater from non-patient toilets, and greywater, said method comprising: handling said blackwater from the patient toilets in a first wastewater handling system for preventing medical substances, such as antibiotics, present in dissolved state in the blackwater from the patient toilets from entering a public sewage system, wherein vacuum toilets are used as said patient toilets; and handling said blackwater from the non-patient toilets and said greywater in a separate gravity-based second wastewater handling system , wherein water-flushed toilets are used as said non-patient toilets; wherein the amount of wastewater handled by the first wastewater handling system is less than the amount of wastewater handled by the gravity-based second wastewater handling system; and wherein said handling the blackwater from the vacuum toilets in the first wastewater handling system comprises: ejecting by vacuum from a plurality of vacuum patient toilets blackwater containing said medical substances present in dissolved state in bodily waste; subjecting the ejected blackwater to an initial treatment including a bacteria reduction and a fragmentation , for producing an initially treated blackwater slurry; transferring the blackwater slurry to at least one central buffer tank and temporarily storing the blackwater slurry in said at least one central buffer tank ; transferring the blackwater slurry from said at least one buffer tank to a central vaporization unit comprising one or more vaporization chambers ; in said one or more vaporization chambers , vaporizing water from the blackwater slurry for producing a water-reduced waste material containing said medical substances; transferring the water-reduced waste material into one or more replaceable waste containers ; and removing and replacing said waste containers containing said waste material. handling said blackwater from the patient toilets in a first wastewater handling system for preventing medical substances, such as antibiotics, present in dissolved state in the blackwater from the patient toilets from entering a public sewage system, wherein vacuum toilets are used as said patient toilets; and handling said blackwater from the non-patient toilets and said greywater in a separate gravity-based second wastewater handling system , wherein water-flushed toilets are used as said non-patient toilets; wherein the amount of wastewater handled by the first wastewater handling system is less than the amount of wastewater handled by the gravity-based second wastewater handling system; and wherein said handling the blackwater from the vacuum toilets in the first wastewater handling system comprises: ejecting by vacuum from a plurality of vacuum patient toilets blackwater containing said medical substances present in dissolved state in bodily waste; subjecting the ejected blackwater to an initial treatment including a bacteria reduction and a fragmentation , for producing an initially treated blackwater slurry; transferring the blackwater slurry to at least one central buffer tank and temporarily storing the blackwater slurry in said at least one central buffer tank ; transferring the blackwater slurry from said at least one buffer tank to a central vaporization unit comprising one or more vaporization chambers ; in said one or more vaporization chambers , vaporizing water from the blackwater slurry for producing a water-reduced waste material containing said medical substances; transferring the water-reduced waste material into one or more replaceable waste containers ; and removing and replacing said waste containers containing said waste material. <EOS>