mhurhangee/patent-ind-claim-en huggingface dataset:
An Aβ fragment-binding molecule characterized in that said molecule is an antibody or fragment thereof that specifically binds to a neo-C-terminal fragment of Aβ peptide obtained by cleavage of said Aβ peptide between two consecutive amino acids located between positions 20 and 26 on the amino acid sequence of said Aβ peptide, but does not bind to Aβ peptides of 40, 42 and/or 43 amino acids (Aβ1-40, Aβ1-42, Aβ1-43).
A compound of Formula (I) wherein R 1 -R 3 each independently are alkyl
A composition for assessing gut function in a subject in need thereof, comprising a fluorescent challenge molecule, wherein the first fluorescent challenge molecule is not substantially absorbed by a healthy gut, and wherein the composition comprises a second fluorescent challenge molecule, wherein the second fluorescent challenge molecule is substantially absorbed by a healthy gut, wherein the first fluorescent challenge molecule is selected from the group consisting of 3,6-diamino-2,5-bis {N-[ -1-carboxy-2-hydroxyethyl]carbamoyl}pyrazine, and 3,6-N,N'-bis(2,3-dihydroxypropyl)-2,5-pyrazinedicarboxamide, or pharmaceutically acceptable salts thereof, and wherein the second fluorescent challenge molecule is 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a pharmaceutically acceptable salt thereof.
A multi-cylinder piston engine having a driving end and a free end, the engine comprising - an engine block , where cylinders are arranged in a first bank (A) and a second bank (B), - a first high-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the cylinders of the first bank (A) and a compressor for supplying pressurized intake air to the cylinders of the engine , - a second high-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the cylinders of the second bank (B) and a compressor for supplying pressurized intake air to the cylinders of the engine , - a first low-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the turbine of the first high-pressure turbocharger and a compressor for supplying pressurized intake air to the compressor of the first high-pressure turbocharger , - a second low-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the turbine of the second high-pressure turbocharger and a compressor for supplying pressurized intake air to the compressor of the second high-pressure turbocharger , and - a first turbocharger bracket having a support surface supporting the high-pressure turbochargers , characterized in that the engine comprises a second turbocharger bracket that is arranged at the free end of the engine and comprises a support surface supporting the low-pressure turbochargers , the support surface of the second turbocharger bracket being at a lower level than the support surface of the first turbocharger bracket , wherein the engine is arranged on a base frame , and the second turbocharger bracket is supported by the base frame . - an engine block , where cylinders are arranged in a first bank (A) and a second bank (B), - a first high-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the cylinders of the first bank (A) and a compressor for supplying pressurized intake air to the cylinders of the engine , - a second high-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the cylinders of the second bank (B) and a compressor for supplying pressurized intake air to the cylinders of the engine , - a first low-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the turbine of the first high-pressure turbocharger and a compressor for supplying pressurized intake air to the compressor of the first high-pressure turbocharger , - a second low-pressure turbocharger comprising a turbine that is arranged to receive exhaust gas from the turbine of the second high-pressure turbocharger and a compressor for supplying pressurized intake air to the compressor of the second high-pressure turbocharger , and - a first turbocharger bracket having a support surface supporting the high-pressure turbochargers ,
A soluble ecto-nucleotide pyrophosphate/phosphodiesterase-1 (NPP1) polypeptide of the formula: PROTEIN-Z-DOMAIN, wherein PROTEIN comprises the NPP1 enzymatic domain of a human NPP1 protein, wherein the human NPP1 protein comprises the amino acid sequence set forth in SEQ ID NO:1 absent the cytosolic and transmembrane domains; wherein DOMAIN comprises the Fc domain of human IgG1; wherein Z is the amino acid sequence L I N; and the polypeptide lacks a negatively-charged bone-targeting domain. PROTEIN comprises the NPP1 enzymatic domain of a human NPP1 protein, wherein the human NPP1 protein comprises the amino acid sequence set forth in SEQ ID NO:1 absent the cytosolic and transmembrane domains; wherein DOMAIN comprises the Fc domain of human IgG1; wherein Z is the amino acid sequence L I N; and the polypeptide lacks a negatively-charged bone-targeting domain.
A half-bridge switching circuit system comprising: a first plurality of switches connected between a first rail voltage and an output on which an output voltage is provided; a second plurality of switches connected between a second rail voltage and the output , the first and second pluralities of switches being controlled via a plurality of switching signals; a plurality of flying capacitors connecting the first and second pluralities of switches; and a plurality of snubber circuits , each of the plurality of flying capacitors being connected in parallel with a respective one of the plurality of snubber circuits , each of the first plurality of switches being connected in parallel with a respective one of the plurality of snubber circuits , and each of the second plurality of switches being connected in parallel with a respective one of the plurality of snubber circuits , each of the plurality of snubber circuits comprising a capacitor and a resistor connected in series with respect to each other. a first plurality of switches connected between a first rail voltage and an output on which an output voltage is provided; a second plurality of switches connected between a second rail voltage and the output , the first and second pluralities of switches being controlled via a plurality of switching signals; a plurality of flying capacitors connecting the first and second pluralities of switches; and a plurality of snubber circuits , each of the plurality of flying capacitors being connected in parallel with a respective one of the plurality of snubber circuits , each of the first plurality of switches being connected in parallel with a respective one of the plurality of snubber circuits , and each of the second plurality of switches being connected in parallel with a respective one of the plurality of snubber circuits , each of the plurality of snubber circuits comprising a capacitor and a resistor connected in series with respect to each other.
A conjugate comprising at least one charged highly branched polymeric dendrimer having conjugated thereto at least one T helper peptide that specifically binds to a professional antigen presenting cell and at least one nucleic acid molecule comprising a sequence encoding at least one antigen, wherein the nucleic acid molecule is an expression vector and the at least one T helper peptide is a Pan-DR epitope (PADRE).
In a differentiated identification system, a method for providing dynamically configured access to a requester, the method comprising: receiving an access request including at least one differentiable voucher from a requester, wherein the differentiable voucher is a voucher that is unique to an access role; assessing the type of the received access request by considering the access request, the differentiable voucher and more than one user signal, wherein each user signal is weighted such that a given user signal has a greater assessment than another user signal; and wherein the user signal comprises information useful in affecting, qualifying, augmenting or modulating the assessment of the user's corresponding access request as well as any inference of the identity and/or intent of the user requesting the access; dynamically configuring an access to at least one service or data based on the assessment of the access request type; and providing the requester at least one dynamically configured access to the at least one service or data. receiving an access request including at least one differentiable voucher from a requester, wherein the differentiable voucher is a voucher that is unique to an access role; assessing the type of the received access request by considering the access request, the differentiable voucher and more than one user signal, wherein each user signal is weighted such that a given user signal has a greater assessment than another user signal; and wherein the user signal comprises information useful in affecting, qualifying, augmenting or modulating the assessment of the user's corresponding access request as well as any inference of the identity and/or intent of the user requesting the access; dynamically configuring an access to at least one service or data based on the assessment of the access request type; and providing the requester at least one dynamically configured access to the at least one service or data.
Process for purifying and/or degerming liquid and/or aqueous suspensions, comprising the following process steps: cavitation treatment of the medium, especially by means of jet cavitation, at a negative pressure of < 1 bar, preferably 0.03 to 0.07 bar, by treatment of the suspension in a ferromagnetic stator having a rotating magnetic field and magnetic and/or magnetizable elements, especially having ferromagnetic needles, wherein upstream or downstream of the cavitation treatment of the suspension in the ferromagnetic stator is solids comminution in a residual solids comminutor (8.1) having at least one residual solids comminution device having a rotating cutting mechanism with rotating cutting blades at a pressure of < 1 bar, preferably 0.01 to 0.7 bar, characterized in that downstream of the cavitation treatment of the suspension by the treatment of the suspension in a ferromagnetic stator is a sedimentation process at a pressure > 1 bar in a sedimentation unit having at least one sedimentation stage, in that the thus processed suspension is supplied to the sedimentation unit at a pressure > 1 bar either directly after the cavitation treatment or from the residual solids comminutor (8.1) downstream of the cavitation treatment and having the at least one residual solids comminution device , wherein a precipitant, lime or milk of lime is supplied to the suspension before entry into the ferromagnetic stator .
A method for performing driving route optimization in field cultivation having at least one cultivation step in which a predefined cultivation area is driven through by an agricultural machine in accordance with a driving route (F 1 -F 5 ) containing a plurality of parallel lanes (S 1 -S 5 ), wherein the driving route (F 1 -F 5 ) is able to be characterized by an orientation (A 1 , A 2 ) of the lanes (S 1 -S 5 ), a positioning (P 1 -P 4 ) that defines positions of all of the lanes (S 1 -S 5 ), and an order (R 1 -R 5 ) in which the lanes (S 1 -S 5 ) are driven through, wherein, the method comprising the steps of: performing, as a cultivation step, an automatic optimization of the order (R 1 -R 5 ) for each of a plurality of combinations of in each case an orientation (A 1 , A 2 ) and a positioning (P 1 -P 4 ) by ascertaining, from a plurality of orders (R 1 -R 5 ), an order (R opt ) that is optimum for this combination in accordance with a defined optimization criterion for performing driving route optimization; performing, as a cultivation step, an automatic optimization of the driving route (F 1 -F 5 ) by ascertaining, from the plurality of combinations, incorporating the optimum order (R opt ) ascertained for the respective combination, a combination that is optimum in accordance with the optimization criterion and that corresponds to an optimum driving route (F opt ) for this cultivation step; and generating control data (D), for controlling at least one agricultural machine during a cultivation step, automatically, wherein the control data represent the optimum driving route (F opt ), wherein the plurality of combinations contains different combinations of a single orientation (A 1 , A 2 ) with different positionings (P 1 -P 4 ). performing, as a cultivation step, an automatic optimization of the order (R 1 -R 5 ) for each of a plurality of combinations of in each case an orientation (A 1 , A 2 ) and a positioning (P 1 -P 4 ) by ascertaining, from a plurality of orders (R 1 -R 5 ), an order (R opt ) that is optimum for this combination in accordance with a defined optimization criterion for performing driving route optimization; performing, as a cultivation step, an automatic optimization of the driving route (F 1 -F 5 ) by ascertaining, from the plurality of combinations, incorporating the optimum order (R opt ) ascertained for the respective combination, a combination that is optimum in accordance with the optimization criterion and that corresponds to an optimum driving route (F opt ) for this cultivation step; and generating control data (D), for controlling at least one agricultural machine during a cultivation step, automatically, wherein the control data represent the optimum driving route (F opt ), wherein the plurality of combinations contains different combinations of a single orientation (A 1 , A 2 ) with different positionings (P 1 -P 4 ).
A steering control device that controls, as a control target, at least a turning section of a steering device , the steering device including a steering section that enables steering of a steering wheel of a vehicle and the turning section that has a structure with a power transmission path cut off between the turning section and the steering section and operates to turn a turning wheel of the vehicle, the steering control device comprising a control unit configured to perform a calculation based on angle information and to control operation of the turning section based on a turning control amount, the angle information being obtained by relating the turning control amount for operating the turning section to a steering angle that is an angle by which the steering wheel is steered, characterized in that the control unit includes a speed increase ratio calculation unit configured to calculate a speed increase ratio based on state variables, and an angle information calculation unit configured to calculate the angle information by converting the steering angle using the speed increase ratio obtained by the speed increase ratio calculation unit; the speed increase ratio represents a ratio of a change amount of a turning angle that is an angle of the turning wheel to a change amount of the steering angle; and the state variables change according to an operation state of at least either the steering device or the vehicle equipped with the steering device . the steering control device comprising a control unit configured to perform a calculation based on angle information and to control operation of the turning section based on a turning control amount, the angle information being obtained by relating the turning control amount for operating the turning section to a steering angle that is an angle by which the steering wheel is steered, characterized in that the control unit includes a speed increase ratio calculation unit configured to calculate a speed increase ratio based on state variables, and an angle information calculation unit configured to calculate the angle information by converting the steering angle using the speed increase ratio obtained by the speed increase ratio calculation unit; the speed increase ratio represents a ratio of a change amount of a turning angle that is an angle of the turning wheel to a change amount of the steering angle; and the state variables change according to an operation state of at least either the steering device or the vehicle equipped with the steering device .
A method for operating an electrically operable parking brake system of a vehicle , wherein a transfer of the electrically operable parking brake system from a released operating state into an applied operating state is initiated and a predeterminable waiting time period is started when the presence of a trigger event is detected which is independent of an operating device provided for manually operating the electrically operable parking brake system and/or used to release the parking brake system when an operating device is faulty, characterised in that the electrically operable parking brake system is transferred into the applied operating state after the expiration of the predeterminable waiting time when the vehicle is standing and the engine is not started during the predeterminable waiting time, and in that the predeterminable waiting time is reset and/or interrupted when the engine is started or the vehicle is rolling.
Device for utilizing waste heat and/or for purifying a flue gas, comprising a chamber with a flue gas inlet , wherein flue gas can be introduced into the chamber via the flue gas inlet , and a flue gas outlet , wherein flue gas is led out of the chamber via the flue gas outlet after flowing through the chamber , wherein the chamber comprises a heat exchanger device , wherein during the flow through the chamber the flue gas is cooled and/or purified, wherein a medium to be heated, for example a fluid, is passed through the heat exchanger device , wherein heat is extracted from the flue gas by the heat exchange between the flue gas and the medium, wherein on an underside of the chamber there is arranged a tub element which is at least partially open towards the top and is filled with liquid , wherein the flue gas is conducted over the liquid surface in such a way that heat is additionally extracted from the flue gas and/or the liquid absorbs particles extracted from the flue gas, wherein the temperature of the flue gas can be brought below its dew point by the heat exchange, wherein at least one substantially vertically extending flue gas guide element is arranged in the chamber , through which the flue gas is guided vertically from top to bottom through the chamber , characterized in that the heat exchange device comprises at least one heat exchanger which is arranged in the at least one flue gas guide element .
An isolated double stranded ribonucleic acid (dsRNA) comprising first and second nucleic acid strands and a duplex region of at least 25 base pairs, wherein said second strand of said dsRNA comprises 1-5 single-stranded nucleotides at its 3' terminus, wherein said second oligonucleotide strand is sufficiently complementary to SEQ. ID NO: 164 or 4938 along at least 19 nucleotides and at most 35 nucleotides of said second oligonucleotide strand length to reduce KRAS target gene expression when said double stranded nucleic acid is introduced into a mammalian cell.
A method for processing a control channel at a user agent to identify at least one of an uplink and a downlink resource allocated by a resource grant within a multi-carrier communication system wherein resource grants are specified by control channel element subsets, wherein each control channel element subset is a control channel candidate, the method comprising the steps of: associating a first subset of control channel candidates on a first carrier with the first carrier (f1), wherein the first subset associated with the first carrier includes first carrier candidates; associating a second subset of control channel candidates on a first carrier with a second carrier (f2), wherein the second subset associated with the second carrier includes second carrier candidates; receiving a control channel candidate on the first carrier (f1); and attempting to decode the received control channel candidate to identify a resource grant for the second carrier (f2), wherein there are first, second, fourth and eighth aggregation levels of control channel candidates, and wherein control channel elements of a second control channel candidate corresponding to the second carrier at each aggregation level are shifted from control channel elements of a first control channel candidate corresponding to the first carrier at each aggregation level by a number of control channel elements. associating a first subset of control channel candidates on a first carrier with the first carrier (f1), wherein the first subset associated with the first carrier includes first carrier candidates; associating a second subset of control channel candidates on a first carrier with a second carrier (f2), wherein the second subset associated with the second carrier includes second carrier candidates; receiving a control channel candidate on the first carrier (f1); and attempting to decode the received control channel candidate to identify a resource grant for the second carrier (f2), wherein there are first, second, fourth and eighth aggregation levels of control channel candidates, and wherein control channel elements of a second control channel candidate corresponding to the second carrier at each aggregation level are shifted from control channel elements of a first control channel candidate corresponding to the first carrier at each aggregation level by a number of control channel elements.
A turbine blisk comprising: an inner rim ; a plurality of adjacent rotor blades extending radially outward from said inner rim ; a shroud segment integrally coupled to each of said plurality of adjacent rotor blades , thereby forming a plurality of adjacent shroud segments; and a gap defined between each of said adjacent shroud segments , wherein said gap has a geometry that facilitates interlocking said plurality of adjacent shroud segments when a torsional force is applied to said plurality of adjacent rotor blades ; wherein said gap defines a plurality of complementary side wall pairs between each of said adjacent shroud segments , each of said plurality of complementary side wall pairs extending at oblique angles relative to each other; characterized in that at least one of said plurality of complementary side wall pairs comprises side walls that extend substantially perpendicularly relative to a centerline of each of said plurality of adjacent rotor blades . an inner rim ; a plurality of adjacent rotor blades extending radially outward from said inner rim ; a shroud segment integrally coupled to each of said plurality of adjacent rotor blades , thereby forming a plurality of adjacent shroud segments; and a gap defined between each of said adjacent shroud segments , wherein said gap has a geometry that facilitates interlocking said plurality of adjacent shroud segments when a torsional force is applied to said plurality of adjacent rotor blades ; wherein said gap defines a plurality of complementary side wall pairs between each of said adjacent shroud segments , each of said plurality of complementary side wall pairs extending at oblique angles relative to each other; characterized in that at least one of said plurality of complementary side wall pairs comprises side walls that extend substantially perpendicularly relative to a centerline of each of said plurality of adjacent rotor blades .