Method for the realization of a system (S) of distribution of radio frequency signals, wherein said system (S) comprises: - a combiner device (C) of radio frequency signals having a plurality of signal connectors (CON1-CON8), at least a first antenna connector (ANT1) operatively connected to at least a first group of said signal connectors (CON1-CON3) and at least a second antenna connector (ANT2) operatively connected to at least a second group of said signal connectors (CON4-CON8); - at least a distribution device (RU) of radio frequency signals provided with a plurality of transmission and reception branches related to different frequency bands; wherein said method comprises the step of connecting said signal connectors (CON1-CON8) to said transmission and reception branches of said distribution device (RU), and wherein said method is characterized in that said step of connecting comprises the following steps: - calculating inter-modulation products of third order (IMD3) generated by at least two downlink signals belonging to a same frequency band; - if said calculated inter-modulation products of third order (IMD3) generated by the at least two downlink signals belonging to the same frequency band are such as to fall within at least a frequency band of uplink signals, then assigning at least a signal connector belonging to said first group (CON1-CON3) to said downlink signals, and assigning at least a signal connector belonging to said second group (CON4-CON8) to said uplink signals; - calculating inter-modulation products of third order (IMD3) generated by at least two downlink signals belonging to different frequency bands; - if said calculated inter-modulation products of third order (IMD3) generated by the at least two downlink signals belonging to the different frequency bands are such as to fall within at least an uplink frequency band, then assigning at least two signal connectors belonging, respectively, to said first group (CON1-CON3) and to said second group (CON4-CON8) to said downlink signals belonging to said different frequency bands. - a combiner device (C) of radio frequency signals having a plurality of signal connectors (CON1-CON8), at least a first antenna connector (ANT1) operatively connected to at least a first group of said signal connectors (CON1-CON3) and at least a second antenna connector (ANT2) operatively connected to at least a second group of said signal connectors (CON4-CON8); - at least a distribution device (RU) of radio frequency signals provided with a plurality of transmission and reception branches related to different frequency bands; - calculating inter-modulation products of third order (IMD3) generated by at least two downlink signals belonging to a same frequency band; - if said calculated inter-modulation products of third order (IMD3) generated by the at least two downlink signals belonging to the same frequency band are such as to fall within at least a frequency band of uplink signals, then assigning at least a signal connector belonging to said first group (CON1-CON3) to said downlink signals, and assigning at least a signal connector belonging to said second group (CON4-CON8) to said uplink signals; - calculating inter-modulation products of third order (IMD3) generated by at least two downlink signals belonging to different frequency bands; - if said calculated inter-modulation products of third order (IMD3) generated by the at least two downlink signals belonging to the different frequency bands are such as to fall within at least an uplink frequency band, then assigning at least two signal connectors belonging, respectively, to said first group (CON1-CON3) and to said second group (CON4-CON8) to said downlink signals belonging to said different frequency bands. <EOS>