A method implemented in a computer infrastructure having computer executable code tangibly embodied on one or more non-transitory storage devices having programming instructions operable to: perform one or more quality control tests using a predetermined number and type of control fluids, a predetermined number of sample testing cartridges of a set of sample testing cartridges, wherein each sample testing cartridge from the set of sample testing cartridges has a same lot number assigned from a manufacturer, and at least one of a plurality of instruments to generate quality control test data; transmit the quality control test data from the at least one of the plurality of instruments to a data manager; determine a compliance status of the set of sample testing cartridges at the data manager based on whether the quality control test data is within range of predetermined cartridge test target values; store the determined compliance status for the set of sample testing cartridges in a data table; transmit the data table from the data manager to each of the plurality of instruments; enable use of the set of sample testing cartridges on each of the plurality of instruments for performing one or more analytical tests on biological samples when the compliance status stored in the data table indicates the set of sample testing cartridges are in compliance; and at least partially disable use of the set of sample testing cartridges on each of the plurality of instruments when the compliance status stored in the data table indicates the set of sample testing cartridges are not in compliance; wherein the predetermined number of testing cartridges of the set of sample testing cartridges is one to five, which comprises a subset of the set of sample testing cartridges. perform one or more quality control tests using a predetermined number and type of control fluids, a predetermined number of sample testing cartridges of a set of sample testing cartridges, wherein each sample testing cartridge from the set of sample testing cartridges has a same lot number assigned from a manufacturer, and at least one of a plurality of instruments to generate quality control test data; transmit the quality control test data from the at least one of the plurality of instruments to a data manager; determine a compliance status of the set of sample testing cartridges at the data manager based on whether the quality control test data is within range of predetermined cartridge test target values; store the determined compliance status for the set of sample testing cartridges in a data table; transmit the data table from the data manager to each of the plurality of instruments; enable use of the set of sample testing cartridges on each of the plurality of instruments for performing one or more analytical tests on biological samples when the compliance status stored in the data table indicates the set of sample testing cartridges are in compliance; and at least partially disable use of the set of sample testing cartridges on each of the plurality of instruments when the compliance status stored in the data table indicates the set of sample testing cartridges are not in compliance; <EOS>