A computer-implemented method of manipulating medical image annotations, the method comprising: receiving an image of at least a portion of an individual's anatomy; using a computer processor for automatically determining a first annotation of an anatomical feature identified in the image; presenting to the user an electronic display of the first annotation; prompting the user to input into the computer processor one or more responses to presented validation requests for verifying the first annotation; determining an order for presentation of annotations to the user; identifying a second annotation for an anatomical feature identified in the image, the second annotation following the first annotation according to the determined order; presenting to the user an electronic display of the second annotation for the anatomical feature identified in the image upon verification of or modification to the first annotation via the one or more validation requests, the presentation of the second annotation being subsequent to the presentation of the first annotation according to the determined order; prompting the user to input into the computer processor one or more responses to presented validation requests for verifying the second annotation; and generating, using a processor, a validated model of the individual's anatomy based on one or more user interactions with the one or more validation requests; characterized in that the method further comprises: determining one or more modifications to the first annotation or the second annotation; and determining a re-computation of one or more subsequent annotations based on the one or more modifications. receiving an image of at least a portion of an individual's anatomy; using a computer processor for automatically determining a first annotation of an anatomical feature identified in the image; presenting to the user an electronic display of the first annotation; prompting the user to input into the computer processor one or more responses to presented validation requests for verifying the first annotation; determining an order for presentation of annotations to the user; identifying a second annotation for an anatomical feature identified in the image, the second annotation following the first annotation according to the determined order; presenting to the user an electronic display of the second annotation for the anatomical feature identified in the image upon verification of or modification to the first annotation via the one or more validation requests, the presentation of the second annotation being subsequent to the presentation of the first annotation according to the determined order; prompting the user to input into the computer processor one or more responses to presented validation requests for verifying the second annotation; and generating, using a processor, a validated model of the individual's anatomy based on one or more user interactions with the one or more validation requests; characterized in that the method further comprises: determining one or more modifications to the first annotation or the second annotation; and determining a re-computation of one or more subsequent annotations based on the one or more modifications. determining one or more modifications to the first annotation or the second annotation; and determining a re-computation of one or more subsequent annotations based on the one or more modifications. <EOS>