Tetrahydro- β -carboline alkaloid derivatives with a structure shown in the following general formula (Ic) characterized in that the tetrahydro- β -carboline alkaloid derivatives are chosen from the group consisting of: (1 S ,3 S )- N '-benzylidene-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -1) (1 S ,3 S )- N '-(4-tert-butylbenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -2) (1 S ,3 S )- N '-(4-dimethylaminobenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -3) (1 S ,3 S )- N '-(4-nitrobenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -4) (1 S ,3 S )- N '-(4-chlorobenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -5) (1 S ,3 S )- N '-(2,4-dichlorobenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -6) (1 S ,3 S )- N '-(3,4-dichlorobenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -7) (1 S ,3 S )- N '-(4-methoxybenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -8) (1 S ,3 S )- N '-(3-methoxybenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -9) (1 S ,3 S )- N '-(2-methoxybenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -10) (1 S ,3 S )-N'-(3,4-dimethoxybenzylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -11) (1 S ,3 S )- N '-(benzo[ d ] dioxymethylene-5-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -12) (1 S ,3 S )- N '-(2,3-dihydrobenzo[ b ] dioxin-6-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4-b]indol-3-formylhydrazine (I c -13) (1 S ,3 S )- N '-(6-hydroxynaphthalene-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -14) (1 S ,3 S )- N '-(pyridine-4-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -15) (1 S ,3 S )- N '-(pyridine-3-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -16) (1 S ,3 S )- N '-(pyridine-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -17) (1 S ,3 S )- N '-(furan-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3 - formylhydrazine (I c -18) (1 S ,3 S )-N'-(pyrrole-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -19) (1 S ,3 S )- N '-(thiophene-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -20) (1 S ,3 S )- N '-(imidazole-2-methylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -21) (1 S ,3 S )- N '-(( E )-but-2-enylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -22) (1 S ,3 S )- N '-butylidene-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -23) (1 S ,3 S )- N '-(cyclohexylmethylene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -25) (1 S ,3 S )- N '-(2,2-dimethylpropylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -26) (1 S ,3 S )- N '-(1-phenylethylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -27) (1 S ,3 S )- N '-(3,3-dimethyl-2-butylidene)-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -28) (1 S ,3 S )- N '-cyclohexylidene-1-methyl-2,3,4,9-tetrahydropyridino[3,4- b ]indol-3-formylhydrazine (I c -29) <EOS>