A compound having the structure: wherein Y 1 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -( C 3 -C 8 cycloalkyl) ; Y 2 is H, - (C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl) -O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -(C 3 -C 8 cycloalkyl) ; Y 3 is H; Y 4 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl)-( C 3 -C 8 cycloalkyl) ; Y 5 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -( C 3 -C 8 cycloalkyl) ; R 1 , R 2 , R 3 and R 4 are each independently H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), -(aryl), -(heteroaryl), -(C 1 -C 12 heteroalkyl), -(C 1 -C 12 hydroxyalkyl), -(C 1 -C 12 alkyl) -(aryl), -(C 1 -C 12 alkyl)-(heteroaryl), -(C 1 -C 12 alkyl) -OH, -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl), -OH, -NH 2 , or -C(O)-NH-(C 1 -C 12 alkyl), each without substitution; and R 5 , R 6 , R 7 , R 8 are each independently -H, halogen, -CN, -CF 3 , -OCF 3 , -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), -(aryl), - (heteroaryl), -(C 1 -C 12 heteroalkyl), -(C 1 -C 12 hydroxyalkyl), -NH 2 , - NH-(C 1 -C 12 alkyl), -NH- (C 2 -C 12 alkenyl), -NH-(C 2 -C 12 alkynyl), -NH-(aryl), -NH-(heteroaryl), -OH, -OAc, -CO 2 H, -CO 2 -(C 1 -C 12 alkyl), -O-C(O)(C 1 -C 12 alkyl), -O-(C 1 -C 12 alkyl), -O-(C 2 -C 12 alkenyl), -O-(C 2 -C 12 alkynyl), -O-(aryl), -O-(heteroaryl), C(O)-NH 2 , C(O)-NH-(C 1 -C 12 alkyl), or C(O)-NH-(aryl), each without substitution, or a pharmaceutically acceptable salt thereof. Y 1 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -( C 3 -C 8 cycloalkyl) ; Y 2 is H, - (C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl) -O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -(C 3 -C 8 cycloalkyl) ; Y 3 is H; Y 4 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl)-( C 3 -C 8 cycloalkyl) ; Y 5 is H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), - (cycloalkyl), -(haloalkyl), -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl) or -(C 1 -C 12 alkyl) -( C 3 -C 8 cycloalkyl) ; R 1 , R 2 , R 3 and R 4 are each independently H, -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), -(aryl), -(heteroaryl), -(C 1 -C 12 heteroalkyl), -(C 1 -C 12 hydroxyalkyl), -(C 1 -C 12 alkyl) -(aryl), -(C 1 -C 12 alkyl)-(heteroaryl), -(C 1 -C 12 alkyl) -OH, -(C 1 -C 12 alkyl)-O-(C 1 -C 12 alkyl), -OH, -NH 2 , or -C(O)-NH-(C 1 -C 12 alkyl), each without substitution; and R 5 , R 6 , R 7 , R 8 are each independently -H, halogen, -CN, -CF 3 , -OCF 3 , -(C 1 -C 12 alkyl), -(C 2 -C 12 alkenyl), -(C 2 -C 12 alkynyl), -(aryl), - (heteroaryl), -(C 1 -C 12 heteroalkyl), -(C 1 -C 12 hydroxyalkyl), -NH 2 , - NH-(C 1 -C 12 alkyl), -NH- (C 2 -C 12 alkenyl), -NH-(C 2 -C 12 alkynyl), -NH-(aryl), -NH-(heteroaryl), -OH, -OAc, -CO 2 H, -CO 2 -(C 1 -C 12 alkyl), -O-C(O)(C 1 -C 12 alkyl), -O-(C 1 -C 12 alkyl), -O-(C 2 -C 12 alkenyl), -O-(C 2 -C 12 alkynyl), -O-(aryl), -O-(heteroaryl), C(O)-NH 2 , C(O)-NH-(C 1 -C 12 alkyl), or C(O)-NH-(aryl), each without substitution, <EOS>