mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of formula (I-A) or (I-B): or including any tautomeric or stereochemically isomeric form thereof, wherein for (I-A) X 1 is N, X 2 is N and X 3 is CH; or X 1 is CR 3d , X 2 is N and X 3 is CH; or X 1 is CR 3d , X 2 is CR 3d and X 3 is N; for (I-B) X 1 is N or CR 3d ; each R 2 is independently selected from hydroxyl and C 1-4 alkoxy; D represents a 5 or 6 ring membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O or S, wherein said heterocyclyl may be optionally substituted by one or more (e.g. 1, 2 or 3) R 1 groups; R 1 represents hydrogen, or C 1-6 alkyl; R 3a represents hydroxyl, hydroxyC 1-6 alkoxy, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyl substituted with -C(=O)-O-C 1-6 alkyl, or C 1-6 alkyl substituted with R 9 ; R 3b represents hydrogen or hydroxyl; or for a compound of formula (I-A), R 3a and R 3b may also be taken together to form =O, or to form =CH-C 0-4 alkyl substituted with R 3c ; R 3c represents hydroxyl, -C(=O)-NR 14 R 15 , or cyano; R 3d represents hydrogen; R 9 represents a 5 membered aromatic heterocycle optionally substituted with -S(=O) 2 -NR 14 R 15 ; R 14 and R 15 each independently represent hydrogen or C 1-4 alkyl; n independently represents an integer equal to 1 or 2; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. for (I-A) X 1 is N, X 2 is N and X 3 is CH; or X 1 is CR 3d , X 2 is N and X 3 is CH; or X 1 is CR 3d , X 2 is CR 3d and X 3 is N; for (I-B) X 1 is N or CR 3d ; each R 2 is independently selected from hydroxyl and C 1-4 alkoxy; D represents a 5 or 6 ring membered monocyclic heterocyclyl containing at least one heteroatom selected from N, O or S, wherein said heterocyclyl may be optionally substituted by one or more (e.g. 1, 2 or 3) R 1 groups; R 1 represents hydrogen, or C 1-6 alkyl; R 3a represents hydroxyl, hydroxyC 1-6 alkoxy, C 1-6 alkyl, hydroxyC 1-6 alkyl, C 1-6 alkyl substituted with -C(=O)-O-C 1-6 alkyl, or C 1-6 alkyl substituted with R 9 ; R 3b represents hydrogen or hydroxyl; or for a compound of formula (I-A), R 3a and R 3b may also be taken together to form =O, or to form =CH-C 0-4 alkyl substituted with R 3c ; R 3c represents hydroxyl, -C(=O)-NR 14 R 15 , or cyano; R 3d represents hydrogen; R 9 represents a 5 membered aromatic heterocycle optionally substituted with -S(=O) 2 -NR 14 R 15 ; R 14 and R 15 each independently represent hydrogen or C 1-4 alkyl; n independently represents an integer equal to 1 or 2;
A cyclic peptide comprising an amino acid sequence represented Formula : in Formula , X a and X b , and X c and X d each independently represent amino acid residues crosslinked through a thioether bond; X 1 to X 5 each independently represent an amino acid residue; R represents an arginine residue; G represents a glycine residue; D represents an aspartic acid residue; and m1 to m5 each independently represent an integer of 0 or more, provided that a total number of amino acid residues represented by X a , X b , X c , and X d , amino acid residues represented by X 1 , X 3 , and X 4 , and amino acid residues of RGD is 7 to 16. in Formula , X a and X b , and X c and X d each independently represent amino acid residues crosslinked through a thioether bond; X 1 to X 5 each independently represent an amino acid residue; R represents an arginine residue; G represents a glycine residue; D represents an aspartic acid residue; and m1 to m5 each independently represent an integer of 0 or more, provided that a total number of amino acid residues represented by X a , X b , X c , and X d , amino acid residues represented by X 1 , X 3 , and X 4 , and amino acid residues of RGD is 7 to 16.
Method for automatically monitoring a glue valve during its operation, preferably during the process of producing and/or packaging cigarettes or other smokable items, in particular in order to detect soiling of the outlet nozzle of the glue valve , in which an electrical capacitor field which is oriented in particular transversely or substantially transversely to the direction of movement of the portion of glue is created below the outlet nozzle of the glue valve with the aid of a capacitor , in particular a stationary capacitor, with the result that portions of glue emerging from the glue valve must pass through the capacitor field, and in which metrology is used to monitor whether a disturbance in the capacitor field that changes the capacitance of the capacitor occurs, wherein it is determined, during the metrological monitoring, whether the function of the glue valve , in particular its discharge of glue, is disturbed, wherein at least one parameter characterizing the respective portion of glue or the respective discharge of the portion of glue, in particular the length of the portion of glue , the speed of the portion of glue , the direction of movement of the portion of glue or the quality of the portion of glue , is determined during the metrological monitoring, characterized in that an inhomogeneous capacitor field generated by an annular capacitor is created below the glue valve outlet nozzle , with the result that portions of glue emerging from the glue valve must pass through this capacitor field, or in that at least two inhomogeneous capacitor fields which follow one another in the direction of movement of the portions of glue emerging from the glue valve outlet nozzle and are generated by pairs of capacitor plates are created in each case below the glue valve outlet nozzle, with the result that portions of glue emerging from the glue valve must pass through these two capacitor fields, wherein the two capacitor fields are at an angle to one another, in particular at an angle of 90°.
An electrode device for delivering electrical pulse stimuli to a patient's cochlear region, the electrode device comprising: a lead comprising a single elongate insulated electrical conductor; a single electrode disposed at a distal end of the lead and in electrical communication with the insulated electrical conductor, wherein the electrode is configured to be intraosseously placed within a hole created in target tissue to deliver the electrical pulse stimuli to the patient's cochlear region; and an anchor element disposed adjacent to the electrode, characterised in that the electrode is an electrode screw including an electrode core, the anchor element including a fenestration, wherein the electrode screw is configured to be passed through the fenestration in the anchor element into the hole created in the target tissue and to anchor the electrode device intraosseously to the target tissue, and wherein the electrode core is configured to deliver the electrical pulse stimuli intraosseously to the target tissue with which it makes contact. a lead comprising a single elongate insulated electrical conductor; a single electrode disposed at a distal end of the lead and in electrical communication with the insulated electrical conductor, wherein the electrode is configured to be intraosseously placed within a hole created in target tissue to deliver the electrical pulse stimuli to the patient's cochlear region; and an anchor element disposed adjacent to the electrode, characterised in that the electrode is an electrode screw including an electrode core, the anchor element including a fenestration, wherein the electrode screw is configured to be passed through the fenestration in the anchor element into the hole created in the target tissue and to anchor the electrode device intraosseously to the target tissue, and wherein the electrode core is configured to deliver the electrical pulse stimuli intraosseously to the target tissue with which it makes contact. wherein the electrode screw is configured to be passed through the fenestration in the anchor element into the hole created in the target tissue and to anchor the electrode device intraosseously to the target tissue, and wherein the electrode core is configured to deliver the electrical pulse stimuli intraosseously to the target tissue with which it makes contact.
A method of installing a fixture , such as a bracket, in or on a structure (F) of an aircraft or spacecraft, for mounting or attaching one or more items or systems with respect to the structure (F), comprising the steps of: arranging a head of an additive manufacturing apparatus in, on or adjacent the structure (F); and forming the fixture in situ on the structure (F) with the head of the apparatus based on a digital model (M) of the fixture , wherein the fixture is installed in or on the structure (F) by connecting the fixture to the structure (F) as the fixture is formed, and wherein the step of forming the fixture in situ comprises: forming an anchored portion of the fixture which is non-movably fixed to the structure (F); and forming an operable portion of the fixture which is movable relative to the anchored portion ; wherein the operable portion is formed locally attached to the structure (F) and is separable by peeling or breaking the local attachment, for movement relative to the anchored portion . arranging a head of an additive manufacturing apparatus in, on or adjacent the structure (F); and forming the fixture in situ on the structure (F) with the head of the apparatus based on a digital model (M) of the fixture , wherein the fixture is installed in or on the structure (F) by connecting the fixture to the structure (F) as the fixture is formed, and wherein the step of forming the fixture in situ comprises: forming an anchored portion of the fixture which is non-movably fixed to the structure (F); and forming an operable portion of the fixture which is movable relative to the anchored portion ; wherein the operable portion is formed locally attached to the structure (F) and is separable by peeling or breaking the local attachment, for movement relative to the anchored portion . forming an anchored portion of the fixture which is non-movably fixed to the structure (F); and forming an operable portion of the fixture which is movable relative to the anchored portion ; wherein the operable portion is formed locally attached to the structure (F) and is separable by peeling or breaking the local attachment, for movement relative to the anchored portion .
A method for bonding a first substrate with a second substrate at mutually facing contact faces of the substrates with the following steps, in particular the following sequence: - holding of the first substrate to a first holding surface (1s, 1s', 1s", 1s''') of a first holding device (1, 1' 1", 1''', 1 IV , 1 V , 1 VI , 1 VII ) and holding of the second substrate to a second holding surface (1s, 1s', 1s", 1s''') of a second holding (1, 1' 1", 1''', 1 IV , 1 V , 1 VI , 1 VII ) - fixing of the substrates to the holding surfaces (1s, 1s', 1s", 1s''') by means of fixing elements (2, 2', 2", 2'''), - curvature of at least one of the contact faces before contacting of the contact faces , characterised in that , after the contacting, only those fixing elements (2, 2', 2", 2''') are first switched off which are arranged uniaxially along a single contacting axis (X), and the remaining fixing elements (2, 2', 2", 2''') remain switched on, so that the substrates are first joined together only uniaxially along the contacting axis (X), wherein the remaining fixing elements (2, 2', 2", 2''') are thereafter switched off, so that the substrates are joined together over the whole area. - holding of the first substrate to a first holding surface (1s, 1s', 1s", 1s''') of a first holding device (1, 1' 1", 1''', 1 IV , 1 V , 1 VI , 1 VII ) and holding of the second substrate to a second holding surface (1s, 1s', 1s", 1s''') of a second holding (1, 1' 1", 1''', 1 IV , 1 V , 1 VI , 1 VII ) - fixing of the substrates to the holding surfaces (1s, 1s', 1s", 1s''') by means of fixing elements (2, 2', 2", 2'''), - curvature of at least one of the contact faces before contacting of the contact faces ,
An interactive exercise apparatus for guiding a user to perform exercises, comprising: a frame ; a mirror movably mounted on the frame , the mirror configured to reflect an image of the user in front of the mirror ; a display device disposed on a backside of the mirror and being visible through the mirror , the display device provided to show workout information and video content for the user to view, the video content including a guiding image for guiding the user to perform an exercise; a driving mechanism mounted between the frame and the mirror , and electrically driving the mirror to move with respect to the frame ; a determination unit configured to determine location and posture of the user who is performing the exercise; and a control unit electrically connected to the driving mechanism and the determination unit , the control unit being operable to control the driving mechanism according to the location or posture of the user identified by the determination unit so as to control the mirror to move to a suitable position where the user can see their reflected image . a frame ; a mirror movably mounted on the frame , the mirror configured to reflect an image of the user in front of the mirror ; a display device disposed on a backside of the mirror and being visible through the mirror , the display device provided to show workout information and video content for the user to view, the video content including a guiding image for guiding the user to perform an exercise; a driving mechanism mounted between the frame and the mirror , and electrically driving the mirror to move with respect to the frame ; a determination unit configured to determine location and posture of the user who is performing the exercise; and a control unit electrically connected to the driving mechanism and the determination unit , the control unit being operable to control the driving mechanism according to the location or posture of the user identified by the determination unit so as to control the mirror to move to a suitable position where the user can see their reflected image .
An assembly comprising: - an elongate structural member ; - a pre-cast casting disposed around the structural member , the casting comprising: - an elongate heat insulating tube, the heat insulating tube made of a heat insulating material comprising an intumescent material providing passive fire protection; and - a support tube made of a non-intumescent material; and - a stabilising element arranged to maintain a gap between the inner circumferential surface of the heat insulating tube and an outer surface of the structural member , characterised in that the heat insulating tube is in the form of a complete tube having a continuous inner circumferential surface and a continuous outer circumferential surface and the support tube is encapsulated within the heat insulating tube between the inner circumferential surface and the outer circumferential surface . - an elongate structural member ; - a pre-cast casting disposed around the structural member , the casting comprising: - an elongate heat insulating tube, the heat insulating tube made of a heat insulating material comprising an intumescent material providing passive fire protection; and - a support tube made of a non-intumescent material; and - an elongate heat insulating tube, the heat insulating tube made of a heat insulating material comprising an intumescent material providing passive fire protection; and - a support tube made of a non-intumescent material; and - a stabilising element arranged to maintain a gap between the inner circumferential surface of the heat insulating tube and an outer surface of the structural member ,
Sports in-ear headphone adapted to be worn during sports, comprising a housing for accommodating an electro-acoustic transducer and an extension adapter unit which is coupled to the housing of the in-ear headphone, wherein the extension adapter unit comprises an extension unit with an upper portion with a curvature for fitting into an ear of a user and at least one flexible coupling element (22-25) for coupling the upper portion to the housing of the in-ear headphone, characterized in that the upper portion has a first end and a second end that enclose the region of the curvature , and that the upper portion with the curvature is selected such, that the upper portion fits into the crus inferior anthelicis, the antihelix and the concha of the ear of a user, and that the second end can rest on the crus inferior anthelicis and the first end can rest in the concha of the user's ear, whereby a secure and tight fit in the user's ear is enabled, namely on the crus inferior anthelicis, the antihelix and the concha. a housing for accommodating an electro-acoustic transducer and an extension adapter unit which is coupled to the housing of the in-ear headphone, wherein the extension adapter unit comprises an extension unit with an upper portion with a curvature for fitting into an ear of a user and at least one flexible coupling element (22-25) for coupling the upper portion to the housing of the in-ear headphone, characterized in that the upper portion has a first end and a second end that enclose the region of the curvature , and that the upper portion with the curvature is selected such, that the upper portion fits into the crus inferior anthelicis, the antihelix and the concha of the ear of a user, and that the second end can rest on the crus inferior anthelicis and the first end can rest in the concha of the user's ear, whereby a secure and tight fit in the user's ear is enabled, namely on the crus inferior anthelicis, the antihelix and the concha.
An electronic device (40; 75) comprising; - a secure element (ES) comprising a plurality of contacts , said secure element being able to cooperate with a first reader (RD1) external to said electronic device according to a contact mode by using at least one of said contacts; - a processing unit external to the secure element, said processing unit being able to send a command (CMD2) to the secure element (ES) via at least one of said contacts ; - a first detection unit (UD1) able to detect whether a contact communication is in progress in contact mode between the secure element (ES) and the first external reader (RD1); and - a monitoring unit (UC1) configured to block the sending, via at least one predefined contact among said plurality of contacts, of each command (CMD2) from the processing unit to the secure element (ES) as long as a said contact communication is in progress, characterized in that the first detection unit (UD1) is able to convert a first voltage detected on one of said external contacts, called power contact (54-1), into a second voltage different from the first voltage, and wherein the processing unit is configured to determine that a said contact communication is in progress between the secure element (ES) and the first external reader (RD1) only if the second voltage is at least equal to a first predetermined threshold value. - a secure element (ES) comprising a plurality of contacts , said secure element being able to cooperate with a first reader (RD1) external to said electronic device according to a contact mode by using at least one of said contacts; - a processing unit external to the secure element, said processing unit being able to send a command (CMD2) to the secure element (ES) via at least one of said contacts ; - a first detection unit (UD1) able to detect whether a contact communication is in progress in contact mode between the secure element (ES) and the first external reader (RD1); and - a monitoring unit (UC1) configured to block the sending, via at least one predefined contact among said plurality of contacts, of each command (CMD2) from the processing unit to the secure element (ES) as long as a said contact communication is in progress,
Method for closing a convertible soft top on a cabriolet vehicle , wherein the convertible soft top is opened and closed in an electric or hydraulic manner and the vehicle comprises an interior space monitoring system and a surroundings monitoring system, wherein image data of the interior space monitoring system and the surroundings monitoring system is transmitted by way of an air interface to a mobile device , wherein the process of opening and/or closing the convertible soft top can be switched by way of the air interface , and wherein the mobile device , is a mobile network device having a display characterized in that the image data of the current vehicle situation are displayed on the display and a control signal of the mobile device effects the actuation of the convertible soft top after a preset time period has elapsed, and in that the mobile device provides a cancel option by means of which the user can cancel the actuation of the convertible soft top at any time.
A lithium transition metal oxide powder for a positive electrode material in a solid-state lithium ion battery, the powder consisting of particles having a core and a surface layer consisting of an inner and an outer layer, wherein the powder has a D50 between 35 and 60μm, wherein the core has the general formula Li x CoO 2 with 0.99<x<1.04 and wherein the inner surface layer comprises Li y Ni 1-a-b Mn a Co b O 2 , with 0<y<1, 0.3<a<0.8 and 0<b<0.3; and wherein the outer surface layer consists of discrete monolithic sub-micron sized particles having the general formula Li 1+z (Ni 1-m-n Mn m Co n ) 1-z O 2 , with 0≤z≤0.05, 0<m≤0.50 and 0<n≤0.70.
An apparatus for generating droplets, the apparatus comprising: a liquid dispenser comprising a liquid outlet adapted to generate a collimated droplet stream; a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprises an outlet arranged to allow the droplet stream to exit therefrom, and further comprising a first conduit wherein the liquid outlet is arranged so as to dispense the droplets within the first conduit of the first fluid device , a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, the second flow device comprising a second conduit and the first fluid flow device is arranged within the second fluid flow device so that the droplet stream exits in the second conduit of the second fluid flow device a liquid dispenser comprising a liquid outlet adapted to generate a collimated droplet stream; a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprises an outlet arranged to allow the droplet stream to exit therefrom, and further comprising a first conduit wherein the liquid outlet is arranged so as to dispense the droplets within the first conduit of the first fluid device , a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, the second flow device comprising a second conduit and the first fluid flow device is arranged within the second fluid flow device so that the droplet stream exits in the second conduit of the second fluid flow device