Machine for inhibiting pathogenic agents during the preparation of beverages based on breast-milk substitutes and/or powdered products or the like, comprising: - a water line starting from a water tank and ending with at least one water outlet; - at least one tank for the powdered preparation, adapted to contain a powdered preparation or the like; said tank being refillable; - a compartment adapted to at least partially accommodate said at least one tank ; - at least one hopper element comprising at least one first inlet adapted to receive the water coming out of said water tank and/or the powdered preparation delivered by said at least one tank for the powdered preparation and a delivery mouth for delivering the water and preparation mixed, wherein - said at least one tank for the powdered preparation can be removably inserted in said machine for preparing a beverage; and - said hopper element can be coupled with and decoupled from the machine ; and - said hopper element comprising a closing element operated to slide between a working position, wherein it does not allow to deliver the water and preparation mixed from said hopper element , and an open position, wherein the delivery of the water and preparation mixed from said hopper element is allowed; characterized in that - said closing element being connected to a control unit configured to make said closing element switch from the working position to the opening position once the inner temperature of the liquid inside the hopper element has exceeded a first threshold value and has dropped back down below a second threshold value, said first threshold value being equal to 70°, said second threshold value being equal to 35°. - a water line starting from a water tank and ending with at least one water outlet; - at least one tank for the powdered preparation, adapted to contain a powdered preparation or the like; said tank being refillable; - a compartment adapted to at least partially accommodate said at least one tank ; - at least one hopper element comprising at least one first inlet adapted to receive the water coming out of said water tank and/or the powdered preparation delivered by said at least one tank for the powdered preparation and a delivery mouth for delivering the water and preparation mixed, wherein - said at least one tank for the powdered preparation can be removably inserted in said machine for preparing a beverage; and - said hopper element can be coupled with and decoupled from the machine ; and - said hopper element comprising a closing element operated to slide between a working position, wherein it does not allow to deliver the water and preparation mixed from said hopper element , and an open position, wherein the delivery of the water and preparation mixed from said hopper element is allowed; characterized in that - said closing element being connected to a control unit configured to make said closing element switch from the working position to the opening position once the inner temperature of the liquid inside the hopper element has exceeded a first threshold value and has dropped back down below a second threshold value, said first threshold value being equal to 70°, said second threshold value being equal to 35°. <EOS>