mhurhangee/patent-ind-claim-en huggingface dataset:
A Transient Receptor Potential Melastatin 8 (TRPM8) antagonist for use in a method for treating or preventing vasomotor symptoms in a subject in need thereof, comprising: administering to the subject an effective amount of the TRPM8 antagonist; wherein the TRPM8 antagonist is represented by the following formula (I): wherein: the partial structure of formula: is a group of formula: Ring B is benzene or pyridine, and a partial structure of formula: is a group of formula: wherein R 1 is (a) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (b) C 3 -C 7 cycloalkyl; (c) C 1 -C 6 alkoxy; or (d) halogen, R 2d is (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (c) C 3 -C 7 cycloalkyl; or (d) C 1 -C 6 alkoxy, R 3a and R 3b are each independently (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl (in which the cycloalkyl may be optionally substituted by 1 to 3 groups selected from C 1 -C 6 alkyl and C 1 -C 6 halogenoalkyl), C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; (c) C 3 -C 7 cycloalkyl which may be optionally substituted by 1 to 7 groups selected from C 1 -C 6 alkyl, C 1 -C 6 halogenoalkyl, and halogen; (d) Ci-Ce alkoxy which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; or (e) halogen, R 3c and R 3d are hydrogen, R 5 and R 6 are hydrogen, n is 1; or a pharmaceutically acceptable salt thereof; wherein the subject is a human subject. the partial structure of formula: is a group of formula: Ring B is benzene or pyridine, and a partial structure of formula: is a group of formula: wherein R 1 is (a) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (b) C 3 -C 7 cycloalkyl; (c) C 1 -C 6 alkoxy; or (d) halogen, R 2d is (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 halogens; (c) C 3 -C 7 cycloalkyl; or (d) C 1 -C 6 alkoxy, R 3a and R 3b are each independently (a) hydrogen; (b) C 1 -C 6 alkyl which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl (in which the cycloalkyl may be optionally substituted by 1 to 3 groups selected from C 1 -C 6 alkyl and C 1 -C 6 halogenoalkyl), C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; (c) C 3 -C 7 cycloalkyl which may be optionally substituted by 1 to 7 groups selected from C 1 -C 6 alkyl, C 1 -C 6 halogenoalkyl, and halogen; (d) Ci-Ce alkoxy which may be optionally substituted by 1 to 7 groups selected from C 3 -C 7 cycloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 halogenoalkoxy, and halogen; or (e) halogen, R 3c and R 3d are hydrogen, R 5 and R 6 are hydrogen, n is 1; or a pharmaceutically acceptable salt thereof; wherein the subject is a human subject.
A display system configured to display, on a display unit , recommended frequencies recommended for use in a wireless device configured to carry out transmission and reception of data by switching between hopping frequencies in a predetermined frequency band, the display system comprising: a measurement unit configured to periodically measure, within a set time period set in advance, frequencies and power levels of radio waves propagating around the wireless device; and a control unit configured to determine, from among frequencies of the radio waves for which the power levels measured by the measurement unit are greater than or equal to a power threshold value set in advance, frequencies with a number of times of being used greater than or equal to a predetermined number of times, or frequencies with a percentage calculated by dividing the number of times of being used by a number of measurement by the measurement unit greater than or equal to a predetermined threshold, as being the non-recommended frequencies , to determine frequencies that are included within the frequency band and that are other than the non-recommended frequencies as being the recommended frequencies , and to cause the display unit to display the recommended frequencies. a measurement unit configured to periodically measure, within a set time period set in advance, frequencies and power levels of radio waves propagating around the wireless device; and a control unit configured to determine, from among frequencies of the radio waves for which the power levels measured by the measurement unit are greater than or equal to a power threshold value set in advance, frequencies with a number of times of being used greater than or equal to a predetermined number of times, or frequencies with a percentage calculated by dividing the number of times of being used by a number of measurement by the measurement unit greater than or equal to a predetermined threshold, as being the non-recommended frequencies , to determine frequencies that are included within the frequency band and that are other than the non-recommended frequencies as being the recommended frequencies , and to cause the display unit to display the recommended frequencies.
Cover for closing a vehicle surface opening, wherein the cover has a frame part which, on one side, is fixed to the cover bottom side at a frame part fixing portion by means of a plastic foamed-on structure which is attached to the cover and, on the other side, makes contact with the cover bottom side at a frame part free portion via at least one spacer , wherein the spacer is formed as punctiform or elongate or as a bead, characterized in that , on its frame part free portion , the frame part contains at least one filling opening for the introduction of a reactive plastic material which forms the spacer , wherein, after it has been fully reacted or cured, the plastic material, which has been introduced through the filling opening into a gap between the frame part free portion of the frame part fixed to the cover and the cover bottom side , holds the frame part free portion in a positioned and/or fixed manner on the cover bottom side as a spacer .
A lacrosse training ball comprising: a shell defining an enclosure having an interior volume, the shell including a plurality of pads connected along a plurality of seams sewn with a thread having a finishing knot; and a filler that includes a mixture of a first material and a second material that substantially occupies the interior volume, wherein the first material comprises a plurality of pellets and the second material comprises a plurality of grains of sand, wherein the shell has a substantially spherical shape having a circumference in the range of about 19.0 to about 21.0 centimeters, and wherein the lacrosse training ball has a weight of about 141.748 to about 148.835 grams (about 5 to about 5.25 ounces). a shell defining an enclosure having an interior volume, the shell including a plurality of pads connected along a plurality of seams sewn with a thread having a finishing knot; and a filler that includes a mixture of a first material and a second material that substantially occupies the interior volume, wherein the first material comprises a plurality of pellets and the second material comprises a plurality of grains of sand, wherein the shell has a substantially spherical shape having a circumference in the range of about 19.0 to about 21.0 centimeters, and wherein the lacrosse training ball has a weight of about 141.748 to about 148.835 grams (about 5 to about 5.25 ounces).
Disc for a brake disc of the ventilated type comprising a braking band defined by two flanges coaxial to an axis (Z), mutually facing and spaced apart to form an interspace , ventilation channels for the cooling of the disc being defined inside the interspace , each channel extending from at least one inlet made on an inner edge of the braking band to at least one outlet made on an outer edge (2") of the braking band , comprising closure means to reversibly close the inlets of all or at least a part of the ventilation channels , said closure means being sensitive to the temperature of the braking band so that, when the temperature of the braking band exceeds a predefined threshold value, they automatically move from a closed position of the inlets, in which the flow of air through the inlets is prevented or at least restricted, to at least one open position of the inlets, in which an air flow is allowed through the inlets, and vice versa wherein the closure means comprising a plurality of obstruction bodies of the inlets suitable to assume at least two different steric configurations depending on whether they are respectively at a temperature below or above a temperature equal to or proportional to the predefined threshold value of the braking band, in a first steric configuration, the obstruction bodies assuming the closed position and in a second steric configuration the obstruction bodies assuming the open position, characterised in that the disc is suitably shaped in one or more portions to guide the movement of the obstruction bodies between said at least two steric configurations.
A reinforcement means for prefabricated parts, comprising multiple longitudinal elements , in particular longitudinal bars, and multiple transverse elements , which connects the longitudinal elements with one another, wherein the longitudinal elements are arranged or designed so that the reinforcement means is independently erectable on ends of the longitudinal elements and that by the transverse elements at least one opening between the transverse elements is defined, wherein the longitudinal elements can be introduced into free spaces between one or multiple reinforcement elements for lateral parts of a prefabricated part, wherein the transverse elements are present as transverse bars and are reinforced with a brace following a zigzag course, characterised in that the reinforcement means in plan view of ends of the longitudinal elements is formed approximately v-shaped.
A first query engine configured to be coupled to a data lake , the data lake configured to store datasets and indexes based on the datasets on the data lake , the first query engine further configured to: receive a workload comprising a plurality of queries directed at the datasets ; generate a set of candidate indexes based on the plurality of queries; select a predetermined number of candidate indexes from the set of candidate indexes based on a determination of an estimated performance improvement provided by the set of candidate indexes to performance of the workload; and build an index of the selected candidate indexes according to an index specification and store the built index at a predetermined location on the data lake , the predetermined location and index metadata included in the built index conforming to the index specification, the index metadata describing a lineage of the built index that is usable by another query engine to determine whether a data source corresponding to the built index has been updated. receive a workload comprising a plurality of queries directed at the datasets ; generate a set of candidate indexes based on the plurality of queries; select a predetermined number of candidate indexes from the set of candidate indexes based on a determination of an estimated performance improvement provided by the set of candidate indexes to performance of the workload; and build an index of the selected candidate indexes according to an index specification and store the built index at a predetermined location on the data lake , the predetermined location and index metadata included in the built index conforming to the index specification, the index metadata describing a lineage of the built index that is usable by another query engine to determine whether a data source corresponding to the built index has been updated.
A wireless transmit receive unit, WTRU, comprising: a processor configured at least to: send a discovery request, the discovery request indicating the WTRU is configured to operate as a relay for discovery of at least one service; receive a discovery response, the discovery response comprising at least one discovery filter and at least one relay service broadcast code; receive service broadcast codes; and if the WTRU determines a received service broadcast code satisfies the at least one discovery filter, broadcast the at least one relay service broadcast code. send a discovery request, the discovery request indicating the WTRU is configured to operate as a relay for discovery of at least one service; receive a discovery response, the discovery response comprising at least one discovery filter and at least one relay service broadcast code; receive service broadcast codes; and if the WTRU determines a received service broadcast code satisfies the at least one discovery filter, broadcast the at least one relay service broadcast code.
Stretchable multilayer film comprising in the following order a. a first outer layer comprising at least 98 wt% of a linear low density polyethylene b. a first inner layer c. a second inner layer d. a third inner layer e. a second outer layer comprising 70% to 30wt% of a linear low density polyethylene and 30 to 70wt% very low density polyethylene (VLDPE), wherein linear low density polyethylene has a density from 915 to 934 kg/m 3 as determined according to ISO 1872-2 and the VLDPE has a density of from 900 to 915 kg/m 3 as determined according to ISO 1872-2; wherein the first inner layer and/or the third inner layer - comprise(s) at least 98wt% of a propylene homopolymer or 98 wt% of a propylene ethylene copolymer, wherein the other inner layer(s) comprise(s) at least 98wt% of a linear low density polyethylene; or - consist(s) essentially of a propylene homopolymer or consist(s) essentially of a propylene ethylene copolymer, wherein the other inner layer(s) consist(s) essentially of a linear low density polyethylene; wherein the first inner layer is in direct contact with the first outer layer, and the third inner layer is in direct contact with the second outer layer. a. a first outer layer comprising at least 98 wt% of a linear low density polyethylene b. a first inner layer c. a second inner layer d. a third inner layer e. a second outer layer comprising 70% to 30wt% of a linear low density polyethylene and 30 to 70wt% very low density polyethylene (VLDPE), - comprise(s) at least 98wt% of a propylene homopolymer or 98 wt% of a propylene ethylene copolymer, wherein the other inner layer(s) comprise(s) at least 98wt% of a linear low density polyethylene; or - consist(s) essentially of a propylene homopolymer or consist(s) essentially of a propylene ethylene copolymer, wherein the other inner layer(s) consist(s) essentially of a linear low density polyethylene;
A treatment catheter for placement in a bodily duct of a patient, the treatment catheter , comprising: an expandable structure , an elongate hollow shaft having a wall with one or more first through holes and one or more second through holes , the one or more first through holes being spaced axially apart from the one or more second through holes , the elongate hollow shaft having a proximal end portion and a distal end portion, the expandable structure being disposed about the distal end portion of the elongate hollow shaft such that the one or more first through holes reside beneath the expandable structure, the one or more second through holes are located proximal to the expandable structure, the treatment catheter further comprising a sleeve positioned along an outer surface of the elongate hollow shaft moveable between first and second axial positions to respectively inhibit or permit the flow of a treatment agent through the one or more second through holes into the bodily duct , and an elongate wire having a seal unit positioned within an inner lumen of the elongate hollow shaft , the seal unit positioned at least partially beneath the expandable structure and being moveable between first and second axial positions to respectively inhibit or permit the flow of an inflation medium between a cavity of the expandable structure and the inner lumen of the hollow shaft through the one or more first through holes , the second axial position being located distal to the first axial position. an expandable structure , an elongate hollow shaft having a wall with one or more first through holes and one or more second through holes , the one or more first through holes being spaced axially apart from the one or more second through holes , the elongate hollow shaft having a proximal end portion and a distal end portion, the expandable structure being disposed about the distal end portion of the elongate hollow shaft such that the one or more first through holes reside beneath the expandable structure, the one or more second through holes are located proximal to the expandable structure, the treatment catheter further comprising the one or more second through holes are located proximal to the expandable structure, the treatment catheter further comprising a sleeve positioned along an outer surface of the elongate hollow shaft moveable between first and second axial positions to respectively inhibit or permit the flow of a treatment agent through the one or more second through holes into the bodily duct , and an elongate wire having a seal unit positioned within an inner lumen of the elongate hollow shaft , the seal unit positioned at least partially beneath the expandable structure and being moveable between first and second axial positions to respectively inhibit or permit the flow of an inflation medium between a cavity of the expandable structure and the inner lumen of the hollow shaft through the one or more first through holes , the second axial position being located distal to the first axial position.
A cell observation apparatus comprising a camera imaging cells contained in a culture vessel and a lighting irradiating the cells with inspection light (L), characterized by comprising: a sterile chamber , an inside of which is maintained in a sterile condition and which contains the culture vessel ; and a transparent observation window provided in a bottom portion of the sterile chamber and having the culture vessel placed thereabove, wherein the camera and the lighting are provided below the observation window, and the cells in the culture vessel are imaged through the observation window by setting the focus of the camera to a bottom surface of the culture vessel, the lighting emits the inspection light (L) as spot light to the bottom surface of the culture vessel by emitting light in a shape of a spot where the light is not diffused, wherein an imaging range of the camera is positioned inside an irradiation range of the inspection light (L) on the bottom surface of the culture vessel, and the cell observation apparatus is provided with an angle adjustment mechanism such that an imaging direction of the camera and an irradiation direction of the lighting (L) are set so as not to be at the same angle relative to an axis orthogonal to the bottom surface of the culture vessel . a sterile chamber , an inside of which is maintained in a sterile condition and which contains the culture vessel ; and a transparent observation window provided in a bottom portion of the sterile chamber and having the culture vessel placed thereabove, wherein the camera and the lighting are provided below the observation window, and the cells in the culture vessel are imaged through the observation window by setting the focus of the camera to a bottom surface of the culture vessel, the lighting emits the inspection light (L) as spot light to the bottom surface of the culture vessel by emitting light in a shape of a spot where the light is not diffused, wherein an imaging range of the camera is positioned inside an irradiation range of the inspection light (L) on the bottom surface of the culture vessel, and the cell observation apparatus is provided with an angle adjustment mechanism such that an imaging direction of the camera and an irradiation direction of the lighting (L) are set so as not to be at the same angle relative to an axis orthogonal to the bottom surface of the culture vessel .
A gas turbine engine powerplant system comprising: an engine package (END1,ENG2) with a high spool and a low spool ; and a start system comprising: a power source which generates air; an engine case structure ; and a nozzle system in the engine case structure in fluid communication with said power source, said nozzle system including a multitude of nozzles circumferentially spaced around the high spool and directed toward a desired direction of the high spool at a rotor of the high spool to spin-up the high spool; wherein the multitude of nozzles are arranged completely around the engine case structure ; wherein said high spool includes an axial flow compressor rotor , and said nozzle system directs said air toward said axial flow compressor rotor; and wherein said high spool includes a centrifugal flow compressor rotor , and said nozzle system directs said air toward said centrifugal flow compressor rotor. an engine package (END1,ENG2) with a high spool and a low spool ; and a start system comprising: a power source which generates air; an engine case structure ; and a nozzle system in the engine case structure in fluid communication with said power source, said nozzle system including a multitude of nozzles circumferentially spaced around the high spool and directed toward a desired direction of the high spool at a rotor of the high spool to spin-up the high spool; wherein the multitude of nozzles are arranged completely around the engine case structure ; wherein said high spool includes an axial flow compressor rotor , and said nozzle system directs said air toward said axial flow compressor rotor; and wherein said high spool includes a centrifugal flow compressor rotor , and said nozzle system directs said air toward said centrifugal flow compressor rotor. a power source which generates air; an engine case structure ; and a nozzle system in the engine case structure in fluid communication with said power source, said nozzle system including a multitude of nozzles circumferentially spaced around the high spool and directed toward a desired direction of the high spool at a rotor of the high spool to spin-up the high spool; wherein the multitude of nozzles are arranged completely around the engine case structure ; wherein said high spool includes an axial flow compressor rotor , and said nozzle system directs said air toward said axial flow compressor rotor; and wherein said high spool includes a centrifugal flow compressor rotor , and said nozzle system directs said air toward said centrifugal flow compressor rotor.