mhurhangee/patent-ind-claim-en huggingface dataset:
A bispecific binding protein capable of binding CD40 and capable of binding mesothelin, comprising two polypeptides of formula (II): scFv X -H-Fc-L-scFv Y (II), wherein L is a polypeptide linker, H is a hinge region, Fc comprises CH2 and CH3 regions of an immunoglobulin, scFv X and scFv Y are each independently a single chain variable fragment, scFv X specifically binds a first antigen, scFv Y specifically binds a second antigen, and one of the two antigens is CD40 and the other is mesothelin; wherein the scFv that binds CD40 comprises a V H having a CDR-H1 according to SEQ ID NO:25, a CDR-H2 according to SEQ ID NO:26, and a CDR-H3 according to SEQ ID NO:27, and a V L having a CDR-L1 according to SEQ ID NO:55, a CDR-L2 according to SEQ ID NO:56, and a CDR-L3 according to SEQ ID NO:57; and wherein the scFv that binds mesothelin comprises a VH having a CDR-H1 according to SEQ ID NO:241, a CDR-H2 according to SEQ ID NO:242, and a CDR-H3 according to SEQ ID NO:243, and a VL having a CDR-L1 according to SEQ ID NO:244, a CDR-L2 according to SEQ ID NO:245, and a CDR-L3 according to SEQ ID NO:246. L is a polypeptide linker, H is a hinge region, Fc comprises CH2 and CH3 regions of an immunoglobulin, scFv X and scFv Y are each independently a single chain variable fragment, scFv X specifically binds a first antigen, scFv Y specifically binds a second antigen, and one of the two antigens is CD40 and the other is mesothelin; wherein the scFv that binds CD40 comprises a V H having a CDR-H1 according to SEQ ID NO:25, a CDR-H2 according to SEQ ID NO:26, and a CDR-H3 according to SEQ ID NO:27, and a V L having a CDR-L1 according to SEQ ID NO:55, a CDR-L2 according to SEQ ID NO:56, and a CDR-L3 according to SEQ ID NO:57; and wherein the scFv that binds mesothelin comprises a VH having a CDR-H1 according to SEQ ID NO:241, a CDR-H2 according to SEQ ID NO:242, and a CDR-H3 according to SEQ ID NO:243, and a VL having a CDR-L1 according to SEQ ID NO:244, a CDR-L2 according to SEQ ID NO:245, and a CDR-L3 according to SEQ ID NO:246.
An optical system arranged to maintain focus of an optical imaging system for ophthalmic imaging with respect to a target, the optical system comprising: an optical element responsive to an applied signal to vary a focal length of the optical element , the variation of the focal length with the applied signal exhibiting hysteresis in a first range of values of the signal, and no hysteresis in a second range of values of the signal; a memory storing data representative of a hysteresis curve which indicates the variation of the focal length with increasing values of the signal and decreasing values of the signal; and a controller configured to continuously control the focal length of the optical element by: generating, based on the stored data, a cyclic signal having one or more discontinuities in each cycle of the cyclic signal, and setting the size of at least one of the one or more discontinuities in each cycle based on the stored data such that a part of the variation of the focal length with the cyclic signal coincides with a part of the variation represented by the stored data; and applying the cyclic signal to the optical element . an optical element responsive to an applied signal to vary a focal length of the optical element , the variation of the focal length with the applied signal exhibiting hysteresis in a first range of values of the signal, and no hysteresis in a second range of values of the signal; a memory storing data representative of a hysteresis curve which indicates the variation of the focal length with increasing values of the signal and decreasing values of the signal; and a controller configured to continuously control the focal length of the optical element by: generating, based on the stored data, a cyclic signal having one or more discontinuities in each cycle of the cyclic signal, and setting the size of at least one of the one or more discontinuities in each cycle based on the stored data such that a part of the variation of the focal length with the cyclic signal coincides with a part of the variation represented by the stored data; and applying the cyclic signal to the optical element . generating, based on the stored data, a cyclic signal having one or more discontinuities in each cycle of the cyclic signal, and setting the size of at least one of the one or more discontinuities in each cycle based on the stored data such that a part of the variation of the focal length with the cyclic signal coincides with a part of the variation represented by the stored data; and applying the cyclic signal to the optical element .
Compounds of formula Ib wherein R 1 is H, acetyl, SF 5 , halo, alkyl, haloalkyl, haloalkoxy or nitrile; R 5 is H; or R 1 and R 5 , and the atoms to which they are bonded, form either an 4-6 membered heterocycle ring comprising a single O heteroatom optionally substituted with one or two substituents independently selected from halo or alkyl, or R 1 and R 5 , and the atoms to which they are bonded, form a 3-6 membered cycloalkyl ring optionally substituted with 1 to 2 substituents independently selected from halo or alkyl; R 2 is H, halo, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl, wherein cycloalkyl or cycloalkylalkyl is optionally substituted with halo; R 3 is H, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl, wherein cycloalkyl or cycloalkylalkyl is optionally substituted with halo; Z is -O-, or -NH-; R 4 is a heterocycle ring optionally substituted with 1 to 3 substituents independently selected from halo, alkyl, haloalkyl, hydroxyalkyl, -OH, oxo, -CO 2 H, cycloalkylalkyl or cycloalkyl optionally substituted with halo; or R 4 is a cycloalkyl optionally substituted with 1 to 3 substituents independently selected from alkyl, halo, haloalkyl and -OH; or R 4 is arylalkyl or heteroarylalkyl wherein arylalkyl or heteroarylalkyl has 1 to 3 substituents independently selected from alkyl, halo, haloalkyl and -OH; and pharmaceutically acceptable salts. R 1 is H, acetyl, SF 5 , halo, alkyl, haloalkyl, haloalkoxy or nitrile; R 5 is H; or R 1 and R 5 , and the atoms to which they are bonded, form either an 4-6 membered heterocycle ring comprising a single O heteroatom optionally substituted with one or two substituents independently selected from halo or alkyl, or R 1 and R 5 , and the atoms to which they are bonded, form a 3-6 membered cycloalkyl ring optionally substituted with 1 to 2 substituents independently selected from halo or alkyl; R 2 is H, halo, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl, wherein cycloalkyl or cycloalkylalkyl is optionally substituted with halo; R 3 is H, alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl, wherein cycloalkyl or cycloalkylalkyl is optionally substituted with halo; Z is -O-, or -NH-; R 4 is a heterocycle ring optionally substituted with 1 to 3 substituents independently selected from halo, alkyl, haloalkyl, hydroxyalkyl, -OH, oxo, -CO 2 H, cycloalkylalkyl or cycloalkyl optionally substituted with halo; or R 4 is a cycloalkyl optionally substituted with 1 to 3 substituents independently selected from alkyl, halo, haloalkyl and -OH; or R 4 is arylalkyl or heteroarylalkyl wherein arylalkyl or heteroarylalkyl has 1 to 3 substituents independently selected from alkyl, halo, haloalkyl and -OH;
An automatic ice maker comprising: a frame; a motor ; and an ice tray comprising: a first end operably and rotationally engaged with the motor ; a second end engaged to the frame such that action of the motor may twist the ice tray ; and a plurality of ice wells defined by a plurality of weirs including a first set of weirs positioned proximate the first end and a second set of weirs positioned proximate the second end and interior weirs positioned therebetween, and wherein each of the first and second sets of weirs and the interior weirs comprise a passage at least partially bifurcating each weir into a first weir portion and a second weir portion, characterised in that each of the passages defined by the first and second sets of weirs have a cross-sectional area that is greater than a cross-sectional area of any one of the passages defined by the interior weirs . a frame; a motor ; and an ice tray comprising: a first end operably and rotationally engaged with the motor ; a second end engaged to the frame such that action of the motor may twist the ice tray ; and a plurality of ice wells defined by a plurality of weirs including a first set of weirs positioned proximate the first end and a second set of weirs positioned proximate the second end and interior weirs positioned therebetween, and wherein each of the first and second sets of weirs and the interior weirs comprise a passage at least partially bifurcating each weir into a first weir portion and a second weir portion, characterised in that each of the passages defined by the first and second sets of weirs have a cross-sectional area that is greater than a cross-sectional area of any one of the passages defined by the interior weirs . a first end operably and rotationally engaged with the motor ; a second end engaged to the frame such that action of the motor may twist the ice tray ; and a plurality of ice wells defined by a plurality of weirs including a first set of weirs positioned proximate the first end and a second set of weirs positioned proximate the second end and interior weirs positioned therebetween, and wherein each of the first and second sets of weirs and the interior weirs comprise a passage at least partially bifurcating each weir into a first weir portion and a second weir portion, characterised in that each of the passages defined by the first and second sets of weirs have a cross-sectional area that is greater than a cross-sectional area of any one of the passages defined by the interior weirs .
A gummy composition, comprising, a gelling component in a sufficient amount to provide a cohesive gelled product, and a low glycemic index sugar component having a glycemic index of not more than 35, wherein the gummy composition comprises not less than 50% weight of the low glycemic index sugar component, and wherein the gummy composition is substantially free of D-glucose, D-fructose, D-sucrose, and sugar alcohols, wherein the low glycemic index sugar component comprises trehalose, isomaltulose and psicose. a gelling component in a sufficient amount to provide a cohesive gelled product, and a low glycemic index sugar component having a glycemic index of not more than 35, wherein the gummy composition comprises not less than 50% weight of the low glycemic index sugar component, and wherein the gummy composition is substantially free of D-glucose, D-fructose, D-sucrose, and sugar alcohols, wherein the low glycemic index sugar component comprises trehalose, isomaltulose and psicose.
A near-field communications device , comprising: a near-field antenna; a conformal material having a first surface and a second surface ; wherein the first surface is dielectrically coupled to the antenna; wherein the second surface is configured to be galvanically coupled to a host-structure ; characterized in that the conformal material has a non-homogeneous pattern of low and higher conductivity regions, and in that the higher conductivity regions are located where the conformal material is most likely to contact the host-structure. a near-field antenna; a conformal material having a first surface and a second surface ; wherein the first surface is dielectrically coupled to the antenna; wherein the second surface is configured to be galvanically coupled to a host-structure ; characterized in that the conformal material has a non-homogeneous pattern of low and higher conductivity regions, and in that the higher conductivity regions are located where the conformal material is most likely to contact the host-structure.
A method for determining whether a human subject is afflicted with Alzheimer's disease ("AD") or non-Alzheimer's dementia ("non-ADD") when the subject is suspected of being afflicted with AD or non-ADD, comprising the steps of (a) synchronizing a population of suitable cells derived from the subject; and (b) in the resulting synchronized cell population, measuring the expression level of a gene known to be differentially expressed between corresponding synchronized cells derived from AD patients and those derived from non-ADD patients, wherein the gene is PHBP8, whereby (i) the subject is afflicted with AD if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from AD patients, and (ii) the subject is afflicted with non-ADD if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from non-ADD patients. (a) synchronizing a population of suitable cells derived from the subject; and (b) in the resulting synchronized cell population, measuring the expression level of a gene known to be differentially expressed between corresponding synchronized cells derived from AD patients and those derived from non-ADD patients, wherein the gene is PHBP8,
Method for producing an electrical component , comprising: - providing a ceramic semiconducting base body having a surface (O10) and a first side area (S10a) lying opposite the surface (O10), wherein a metallic layer is contained within the base body, - arranging at least two further metallic layers separately from one another on the side area (S10a) of the base body, - sintering the arrangement composed of the base body and the further metallic layers , - arranging an electrically insulating layer on the first side area (S10a) between the at least two further metallic layers , - arranging a respective contact layer on the at least two further metallic layers by means of a chemical process, characterized in that , during the arrangement of the contact layers , the material of the base body is removed by the chemical process proceeding from the surface (O10) of the base body , specifically at most as far as the metallic layer arranged within the base body. - providing a ceramic semiconducting base body having a surface (O10) and a first side area (S10a) lying opposite the surface (O10), wherein a metallic layer is contained within the base body, - arranging at least two further metallic layers separately from one another on the side area (S10a) of the base body, - sintering the arrangement composed of the base body and the further metallic layers , - arranging an electrically insulating layer on the first side area (S10a) between the at least two further metallic layers , - arranging a respective contact layer on the at least two further metallic layers by means of a chemical process, characterized in that , during the arrangement of the contact layers , the material of the base body is removed by the chemical process proceeding from the surface (O10) of the base body , specifically at most as far as the metallic layer arranged within the base body.
A microfluidic device , comprising: a gel chamber with a gel matrix disposed therein, the gel chamber including an open top surface region; a fluidic chamber wherein a first interface region is formed between the gel chamber and the fluidic chamber ; and a membrane disposed at the first interface region , the membrane including a first side facing the gel chamber and a second side facing the fluidic chamber ; and a removable cover comprising a chamber and optionally one or more fluidic channels , wherein said chamber substantially aligns with the gel chamber . a gel chamber with a gel matrix disposed therein, the gel chamber including an open top surface region; a fluidic chamber wherein a first interface region is formed between the gel chamber and the fluidic chamber ; and a membrane disposed at the first interface region , the membrane including a first side facing the gel chamber and a second side facing the fluidic chamber ; and a removable cover comprising a chamber and optionally one or more fluidic channels , wherein said chamber substantially aligns with the gel chamber .
Delivery unit having a drive shaft and having a rotor which is driven by the drive shaft and which is arranged rotatably in a pump stator , wherein the drive shaft has an oblique slide plane which interacts with the rotor and which causes the rotor with its rotor axis to tumble about a drive axis of the drive shaft , wherein the rotor has on its end side facing away from the drive shaft a toothing which meshes with a toothing formed on the pump stator , wherein working spaces are formed between the toothing of the rotor and the toothing of the pump stator , characterized in that the drive shaft is arranged in a bearing sleeve which has a shoulder which projects in a radial direction with respect to the drive axis , on which shoulder the pump stator is retained by means of at least one retaining means .
A method of allocating resources in a Digital Subscriber Line network, the network comprising at least one lower-tier digital subscriber line carrying signals according to a first protocol between a transceiver device at a lower-tier network node and a subscriber transceiver device and further comprising at least one higher-tier digital subscriber line carrying signals according to a second protocol between a transceiver device at a higher-tier network node and a subscriber transceiver device, the at least one lower-tier digital subscriber line and the at least one higher-tier digital subscriber line being routed in close proximity to one another for at least a portion of a path between the lower-tier network node and the respective subscriber transceiver device, the first protocol permitting signals to be carried at frequencies in a range having a higher upper limit than the second protocol, the method comprising: obtaining, at a management unit associated with the lower-tier network node, a metric indicating one or more frequencies that are being used for carrying signals on the at least one higher-tier digital subscriber line, and estimating therefrom an upper limit of a frequency range that is being used for carrying signals on the at least one higher-tier digital subscriber line; determining, in dependence on the obtained metric, an updated power spectral density to be applied in respect of the at least one lower-tier digital subscriber line for signals to be carried between the transceiver device at the lower-tier network node and the subscriber transceiver device, the updated power spectral density having a minimum frequency that is above the upper limit of the frequency range that has been estimated as being used for carrying signals on the at least one higher-tier digital subscriber line; and then applying the updated power spectral density in respect of signals carried by the at least one lower-tier digital subscriber line. obtaining, at a management unit associated with the lower-tier network node, a metric indicating one or more frequencies that are being used for carrying signals on the at least one higher-tier digital subscriber line, and estimating therefrom an upper limit of a frequency range that is being used for carrying signals on the at least one higher-tier digital subscriber line; determining, in dependence on the obtained metric, an updated power spectral density to be applied in respect of the at least one lower-tier digital subscriber line for signals to be carried between the transceiver device at the lower-tier network node and the subscriber transceiver device, the updated power spectral density having a minimum frequency that is above the upper limit of the frequency range that has been estimated as being used for carrying signals on the at least one higher-tier digital subscriber line; and then applying the updated power spectral density in respect of signals carried by the at least one lower-tier digital subscriber line.
V-type 4-stroke internal combustion engine having 20 cylinders, having a counter-clockwise or clockwise direction of rotation, comprising a crankshaft, characterized in that the engine further comprises a torsional vibration damper and a flywheel arranged on the crankshaft, wherein the crankshaft has 10 crank throws forming a crank star, wherein in each case the piston rods of the two cylinders of a V-segment are connected to the same crank throw, wherein the crank throws C1 to C10 have one of the following angular sequences in the direction of rotation of the engine when seen from the side of the flywheel, with the crank throws numbered as C1 to C10 when starting from the side of the flywheel: i) C1, C9, C4, C6, C3, C10, C2, C7, C5, C8 ii) C1, C8, C5, C7, C2, C10, C3, C6, C4, C9 iii) C1, C9, C5, C7, C3, C10, C2, C6, C4, C8 iv) C1, C9, C7, C3, C6, C10, C2, C4, C8, C5 v) C1, C7, C5, C8, C2, C10, C4, C6, C3, C9 vi) C1, C9, C7, C3, C5, C10, C2, C4, C8, C6 vii) C1, C6, C8, C4, C2, C10, C5, C3, C7, C9 viii) C1, C5, C8, C4, C2, C10, C6, C3, C7, C9 ix) C1, C8, C4, C6, C2, C10, C3, C7, C5, C9. i) C1, C9, C4, C6, C3, C10, C2, C7, C5, C8 ii) C1, C8, C5, C7, C2, C10, C3, C6, C4, C9 iii) C1, C9, C5, C7, C3, C10, C2, C6, C4, C8 iv) C1, C9, C7, C3, C6, C10, C2, C4, C8, C5 v) C1, C7, C5, C8, C2, C10, C4, C6, C3, C9 vi) C1, C9, C7, C3, C5, C10, C2, C4, C8, C6 vii) C1, C6, C8, C4, C2, C10, C5, C3, C7, C9 viii) C1, C5, C8, C4, C2, C10, C6, C3, C7, C9 ix) C1, C8, C4, C6, C2, C10, C3, C7, C5, C9.
A system, comprising a receptacle and a control system, wherein the receptacle comprises: a basin for receiving a viscous element; at least one sensor physically associated with the basin; at least one actuator responsive to the at least one sensor, wherein actuation of the actuator outputs the viscous element to the basin; a local controller at least partially physically proximate to the basin and capable of controlling the actuation of the at least one actuator ; and and wherein the control system communicative with the local controller over at least open data path , wherein the control system includes a plurality of rules and imposes the plurality of rules on the local controller to dynamically configure at least one of flush volumes and the number of flushes based on a time-based usage model. a basin for receiving a viscous element; at least one sensor physically associated with the basin; at least one actuator responsive to the at least one sensor, wherein actuation of the actuator outputs the viscous element to the basin; a local controller at least partially physically proximate to the basin and capable of controlling the actuation of the at least one actuator ; and and wherein the control system communicative with the local controller over at least open data path , wherein the control system includes a plurality of rules and imposes the plurality of rules on the local controller to dynamically configure at least one of flush volumes and the number of flushes based on a time-based usage model.
A method for preparing cytotoxic dendritic cells from monocytes comprising subjecting monocytes which were isolated from the peripheral blood to non-adhesive culture in the presence of GM-CSF and pegylated interferon α and further conducting non-adhesive culture with the addition of prostaglandin E2 and OK432.