A braking system for motorcycles comprising - a first manual actuator device , operable by means of a lever and / or a pedal, selectively connectable to at least a first braking device placed on a front axle of the vehicle, and/or at least a second braking device placed on said front axle or on a rear axle of the motorcycle, each braking device acting on a relative brake disc or drum , - the first manual actuator device being provided with a hydraulic supply circuit that can be selectively connected to a hydraulic input circuit of at least one of said braking devices by means of a control valve , said control valve being positioned in an operating position, in which it hydraulically disconnects the first manual actuator device from the braking devices , and in an electrical fault position, in which it hydraulically connects the first manual actuator device with at least one of said braking devices , - at least one electro-hydraulic automatic actuator device fluidly connectable to the hydraulic input circuit of at least one of said braking devices for the respective hydraulic actuation thereof, - at least one electromechanical automatic actuator device associated with at least one of said braking devices not provided with a hydraulic input circuit , - the electro-hydraulic automatic actuator devices being associated with the front axle and the electromechanical automatic actuator devices being associated with the rear axle of the motorcycle or vice versa, characterized by - a single control unit operatively connected to the control valve , to the at least one electro-hydraulic automatic actuator device , to the at least one electromechanical automatic actuator device and to the first manual actuator device so as to operate said electro-hydraulic and electromechanical automatic actuator devices and said control valve according to the position or configuration of the first manual actuator device and/or according to the dynamics of the motorcycle. - a first manual actuator device , operable by means of a lever and / or a pedal, selectively connectable to at least a first braking device placed on a front axle of the vehicle, and/or at least a second braking device placed on said front axle or on a rear axle of the motorcycle, each braking device acting on a relative brake disc or drum , - the first manual actuator device being provided with a hydraulic supply circuit that can be selectively connected to a hydraulic input circuit of at least one of said braking devices by means of a control valve , said control valve being positioned in an operating position, in which it hydraulically disconnects the first manual actuator device from the braking devices , and in an electrical fault position, in which it hydraulically connects the first manual actuator device with at least one of said braking devices , - at least one electro-hydraulic automatic actuator device fluidly connectable to the hydraulic input circuit of at least one of said braking devices for the respective hydraulic actuation thereof, - at least one electromechanical automatic actuator device associated with at least one of said braking devices not provided with a hydraulic input circuit , - the electro-hydraulic automatic actuator devices being associated with the front axle and the electromechanical automatic actuator devices being associated with the rear axle of the motorcycle or vice versa, characterized by - a single control unit operatively connected to the control valve , to the at least one electro-hydraulic automatic actuator device , to the at least one electromechanical automatic actuator device and to the first manual actuator device so as to operate said electro-hydraulic and electromechanical automatic actuator devices and said control valve according to the position or configuration of the first manual actuator device and/or according to the dynamics of the motorcycle. <EOS>