A system for integrating diagnosis and treatment for internal tissues, comprising: a scanner configured to image at least a portion of an internal organ of a subject ; an interventional instrument for targeting and accessing biopsy sites in accordance with images from the scanner and to locate focal therapy sites corresponding therewith a tracking system configured to track the interventional instrument ; a processing unit having associated memory storage for storing a program, the program configured to - fuse images taken in real-time by the scanner with images taken with a technology capable of differentiating tissue types, the program configured to guide the interventional instrument using the images from the scanner and - track positions on the images taken with the technology capable of differentiating tissue types and to transform positions of the biopsy sites to corresponding positions in said images , and employ the images taken with the technology capable of differentiating tissue types, the positions of the biopsy sites in these images and pathology results of the biopsies to plan for focal therapy on or near the internal organ, wherein the scanner includes an ultrasonic imaging scanner and the technology capable of differentiating tissue types includes magnetic resonance imaging (MRI). a scanner configured to image at least a portion of an internal organ of a subject ; an interventional instrument for targeting and accessing biopsy sites in accordance with images from the scanner and to locate focal therapy sites corresponding therewith a tracking system configured to track the interventional instrument ; a processing unit having associated memory storage for storing a program, the program configured to - fuse images taken in real-time by the scanner with images taken with a technology capable of differentiating tissue types, the program configured to guide the interventional instrument using the images from the scanner and - track positions on the images taken with the technology capable of differentiating tissue types and to transform positions of the biopsy sites to corresponding positions in said images , and employ the images taken with the technology capable of differentiating tissue types, the positions of the biopsy sites in these images and pathology results of the biopsies to plan for focal therapy on or near the internal organ, - fuse images taken in real-time by the scanner with images taken with a technology capable of differentiating tissue types, the program configured to guide the interventional instrument using the images from the scanner and - track positions on the images taken with the technology capable of differentiating tissue types and to transform positions of the biopsy sites to corresponding positions in said images , and employ the images taken with the technology capable of differentiating tissue types, the positions of the biopsy sites in these images and pathology results of the biopsies to plan for focal therapy on or near the internal organ, wherein the scanner includes an ultrasonic imaging scanner and the technology capable of differentiating tissue types includes magnetic resonance imaging (MRI). <EOS>