mhurhangee/patent-ind-claim-en huggingface dataset:
A computer-implemented method for selecting a final target sequence set for use in the preparation of one or more gRNA of a CRISPR-Cas system wherein each of the one or more gRNA has a guide sequence which is complimentary to a target sequence from a final target sequence set, the method comprising: selecting a set of target sequences for one or more loci in a target human population based on genetic disease etiology, wherein the target sequences do not contain variants occurring above a threshold allele frequency in the target human population, wherein the threshold allele frequency is 1%; removing any target sequences having off-target candidates in haplotypes that occur in at least 0.1% of the target population to define the final target sequence set, wherein off-target candidates have 1 to 3 mismatches between an off target site and the target sequences. selecting a set of target sequences for one or more loci in a target human population based on genetic disease etiology, wherein the target sequences do not contain variants occurring above a threshold allele frequency in the target human population, wherein the threshold allele frequency is 1%; removing any target sequences having off-target candidates in haplotypes that occur in at least 0.1% of the target population to define the final target sequence set, wherein off-target candidates have 1 to 3 mismatches between an off target site and the target sequences.
A strut system for coupling a ram-air turbine , RAT, to an aircraft , comprising: a strut that includes a strut body , the strut having a strut first end that is configured to connect to the aircraft and rotate about a first axis , the strut having a strut second end that is spaced apart from the strut first end by the strut body and is configured to connect to a RAT turbine generator unit , and a damper rod that includes a rod body ; characterised in that the strut has a strut conduit extending from the strut first end toward the strut second end; and further characterised in that the damper rod is disposed within the strut conduit, the damper rod having a rod first end that is fixed within the strut conduit at the strut first end, and a rod second end that is spaced apart from the rod first end by the rod body and is located intermediate the strut first end and the strut second end, wherein the rod second end is configured to move along a second axis that is parallel to the first axis. a strut that includes a strut body , the strut having a strut first end that is configured to connect to the aircraft and rotate about a first axis , the strut having a strut second end that is spaced apart from the strut first end by the strut body and is configured to connect to a RAT turbine generator unit , and a damper rod that includes a rod body ; characterised in that the strut has a strut conduit extending from the strut first end toward the strut second end; and further characterised in that the damper rod is disposed within the strut conduit, the damper rod having a rod first end that is fixed within the strut conduit at the strut first end, and a rod second end that is spaced apart from the rod first end by the rod body and is located intermediate the strut first end and the strut second end, wherein the rod second end is configured to move along a second axis that is parallel to the first axis.
An electronic smoking article comprising: a vapor generating arrangement; and a mouth-end insert , characterized in that said mouth-end insert comprises at least two diverging outlet passages operable to distribute vapor throughout a mouth of a smoker during a puff; and wherein the electronic smoking article further comprises a gasket including a central orifice that is sized and spaced from the mouth-end insert and operable to substantially reduce a velocity of the vapor approaching the mouth-end insert . a vapor generating arrangement; and a mouth-end insert , characterized in that said mouth-end insert comprises at least two diverging outlet passages operable to distribute vapor throughout a mouth of a smoker during a puff; and wherein the electronic smoking article further comprises a gasket including a central orifice that is sized and spaced from the mouth-end insert and operable to substantially reduce a velocity of the vapor approaching the mouth-end insert .
An EUV transmissive membrane comprising: a main layer composed of metallic beryllium that has a first surface and a second surface ; and a pair of surface layers provided on the first surface and the second surface of the main layer , characterized in that each surface layer comprises at least one fluoride selected from beryllium fluoride, beryllium fluoride nitride, beryllium fluoride oxide, and beryllium fluoride nitride oxide. a main layer composed of metallic beryllium that has a first surface and a second surface ; and a pair of surface layers provided on the first surface and the second surface of the main layer , characterized in that each surface layer comprises at least one fluoride selected from beryllium fluoride, beryllium fluoride nitride, beryllium fluoride oxide, and beryllium fluoride nitride oxide.
A method for communication in a wireless network, comprising: receiving information on a first downlink channel from a first sector , and information on a second downlink channel from a second sector , wherein the first downlink channel and the second downlink channel are each carried on a first carrier frequency; transmitting feedback information corresponding to the downlink channel state for the first downlink channel to the first sector; and transmitting feedback information corresponding to the downlink channel state for the second downlink channel to the second sector, wherein the feedback information corresponding to the downlink channel state for the first downlink channel and the feedback information corresponding to the downlink channel state for the second downlink channel are each provided on a first uplink carrier frequency and are jointly encoded on an uplink channel on the first uplink carrier frequency. receiving information on a first downlink channel from a first sector , and information on a second downlink channel from a second sector , wherein the first downlink channel and the second downlink channel are each carried on a first carrier frequency; transmitting feedback information corresponding to the downlink channel state for the first downlink channel to the first sector; and transmitting feedback information corresponding to the downlink channel state for the second downlink channel to the second sector, wherein the feedback information corresponding to the downlink channel state for the first downlink channel and the feedback information corresponding to the downlink channel state for the second downlink channel are each provided on a first uplink carrier frequency and are jointly encoded on an uplink channel on the first uplink carrier frequency.
Attenuated strain of the Porcine Reproductive and Respiratory Syndrome (PRRS) virus deposited under the Budapest Treaty at the Collection Nationale de Cultures de Micro-organismes (CNCM), with n. CNCM 1-4859 on June 5, 2014.
An anti-inflammatory liquid composition for use in the treatment of inflammatory conditions of oral mucosa comprising: a rosin; a shellac; a solvent; and optionally a copal, wherein a content of the rosin is 1 wt% or more and 15 wt% or less relative to a total amount of the composition, and a content of the shellac is 35 wt% or more and 45 wt% or less relative to the total amount of the composition, and a total content of the rosin, the shellac, and the copal, when contained in the composition, is 45 wt% or more and 55 wt% or less relative to the total amount of the composition, wherein the anti-inflammatory liquid composition is in the oral dosage form of a film applied to an inflamed area on the mucous membrane in the oral cavity. a rosin; a shellac; a solvent; and optionally a copal, wherein a content of the rosin is 1 wt% or more and 15 wt% or less relative to a total amount of the composition, and a content of the shellac is 35 wt% or more and 45 wt% or less relative to the total amount of the composition, and a total content of the rosin, the shellac, and the copal, when contained in the composition, is 45 wt% or more and 55 wt% or less relative to the total amount of the composition, wherein the anti-inflammatory liquid composition is in the oral dosage form of a film applied to an inflamed area on the mucous membrane in the oral cavity.
A method for operating a first access node in a dual connectivity, DuCo, handover, the method comprising: receiving , by the first access node, an event trigger for a combined event from a user equipment, UE , wherein the event trigger reflects a combination of a first quality indicator associated with the first access node falling below a first threshold and a second quality indicator associated with a second access node rising above a second threshold relative to a third quality indicator associated with the first access node; sending , by the first access node, to the second access node, a combined instruction for primary secondary cell, PSCell, addition and a role change with the second access node in accordance with the event trigger; adding , by the first access node, the second access node as a PSCell; indicating , by the first access node, to the UE, a role change between the first access node and the second access node; and releasing , by the first access node, a UE context associated with the UE. receiving , by the first access node, an event trigger for a combined event from a user equipment, UE , wherein the event trigger reflects a combination of a first quality indicator associated with the first access node falling below a first threshold and a second quality indicator associated with a second access node rising above a second threshold relative to a third quality indicator associated with the first access node; sending , by the first access node, to the second access node, a combined instruction for primary secondary cell, PSCell, addition and a role change with the second access node in accordance with the event trigger; adding , by the first access node, the second access node as a PSCell; indicating , by the first access node, to the UE, a role change between the first access node and the second access node; and releasing , by the first access node, a UE context associated with the UE.
A pneumatic detector assembly (10;100) comprising: a housing; a sensor tube (40;140); and an alarm switch (20;120) coupled to the sensor tube (40;140), the alarm switch (20;120) having a first contact pin (24;124) and a first bellows (22;122) that includes a first contact face (26;126), the first contact face (26;126) of the first bellows (22;122) configured to be out of contact with the first contact pin (24;124) in a normal operating condition and to be in contact with the first contact pin (24;124) in an alarm condition based on a pressure in the sensor tube (40;140); characterized by : an integrity switch (30;130) coupled to the sensor tube (40;140), the integrity switch (30;130) having a second bellows (32;132) that includes a second contact face (36;136) and a second contact pin (34;134), the second contact face (36;136) of the second bellows (32;132) configured to be in contact with the second contact pin (34;134) in a normal operating condition and to be out of contact with the second contact pin (34;134) in a fault condition. a housing; a sensor tube (40;140); and an alarm switch (20;120) coupled to the sensor tube (40;140), the alarm switch (20;120) having a first contact pin (24;124) and a first bellows (22;122) that includes a first contact face (26;126), the first contact face (26;126) of the first bellows (22;122) configured to be out of contact with the first contact pin (24;124) in a normal operating condition and to be in contact with the first contact pin (24;124) in an alarm condition based on a pressure in the sensor tube (40;140); characterized by : an integrity switch (30;130) coupled to the sensor tube (40;140), the integrity switch (30;130) having a second bellows (32;132) that includes a second contact face (36;136) and a second contact pin (34;134), the second contact face (36;136) of the second bellows (32;132) configured to be in contact with the second contact pin (34;134) in a normal operating condition and to be out of contact with the second contact pin (34;134) in a fault condition.
A measurement system comprising: a shaft extended in a longitudinal direction ; a target wheel configured to rotate with the shaft, wherein the target wheel comprises a plurality of sensor targets (120, 122, 124, 130a-h, 404, 406, 408) circumferentially distributed around the target wheel, and wherein the plurality of sensor targets includes a first plurality of targets that are slanted in the longitudinal direction and a second plurality of targets that are parallel to the longitudinal direction ; a sensor array comprising at least three sensors (114a-f) mounted radially around the shaft and configured to detect the plurality of sensor targets as the target wheel rotates with the shaft; and a controller configured to receive sensor signals from the at least three sensors and determine, based on the sensor signals, at least an axial displacement measurement of the shaft in the longitudinal direction and a radial displacement measurement of the shaft; characterized in that the first plurality of targets includes at least a first slanted target slanted in an opposite orientation, in the longitudinal direction, to at least a second slanted target . a shaft extended in a longitudinal direction ; a target wheel configured to rotate with the shaft, wherein the target wheel comprises a plurality of sensor targets (120, 122, 124, 130a-h, 404, 406, 408) circumferentially distributed around the target wheel, and wherein the plurality of sensor targets includes a first plurality of targets that are slanted in the longitudinal direction and a second plurality of targets that are parallel to the longitudinal direction ; a sensor array comprising at least three sensors (114a-f) mounted radially around the shaft and configured to detect the plurality of sensor targets as the target wheel rotates with the shaft; and a controller configured to receive sensor signals from the at least three sensors and determine, based on the sensor signals, at least an axial displacement measurement of the shaft in the longitudinal direction and a radial displacement measurement of the shaft; characterized in that the first plurality of targets includes at least a first slanted target slanted in an opposite orientation, in the longitudinal direction, to at least a second slanted target .
A flush activation assembly for use in a flush toilet comprising a flush activation bar comprising a first portion and a second portion , the first portion configured to be connected to a first valve assembly and the second portion configured to be connected to a second valve assembly ; a pivot rod (P); and a connector positioned so as to operably connect the pivot rod (P) and the flush activation bar , characterized in that the connector is an adjustable flush connector , the adjustable flush connector comprising a first section , a second section , and an adjustable connector , wherein the flush activation bar is longitudinally movable along the second section of the adjustable flush connector , wherein the adjustable connector comprises a second rotatable connector and the adjustable connector is longitudinally movable along the second section of the adjustable flush connector and rotationally positionable; and wherein the adjustable flush connector is connected to the pivot rod (P) using a first rotatable connector located on the first section of the adjustable flush connector , and the adjustable flush connector is connected to the flush activation bar using the second rotatable connector of the adjustable connector . a flush activation bar comprising a first portion and a second portion , the first portion configured to be connected to a first valve assembly and the second portion configured to be connected to a second valve assembly ; a pivot rod (P); and a connector positioned so as to operably connect the pivot rod (P) and the flush activation bar , characterized in that the connector is an adjustable flush connector , the adjustable flush connector comprising a first section , a second section , and an adjustable connector , wherein the flush activation bar is longitudinally movable along the second section of the adjustable flush connector , wherein the adjustable connector comprises a second rotatable connector and the adjustable connector is longitudinally movable along the second section of the adjustable flush connector and rotationally positionable; and wherein the adjustable flush connector is connected to the pivot rod (P) using a first rotatable connector located on the first section of the adjustable flush connector , and the adjustable flush connector is connected to the flush activation bar using the second rotatable connector of the adjustable connector .
A cleaner sheet comprising: a cleaning surface that is configured to be brought into sliding contact with a surface of an object to be cleaned, wherein the cleaning surface has unevenness, and comprises projections respectively having distal ends configured to be in sliding contact with the object to be cleaned when in use, and the projections are constituted by a member formed to have the projections arranged at intervals (A) from each other in a plane direction of the cleaning surface , characterized in that the member has a hardness of 0.4 MPa or more measured by a nano-indentation method, and the cleaning surface further comprises adhesive recesses that have higher adhesive force than that of the member and are exposed on the cleaning surface . a cleaning surface that is configured to be brought into sliding contact with a surface of an object to be cleaned, wherein the cleaning surface has unevenness, and comprises projections respectively having distal ends configured to be in sliding contact with the object to be cleaned when in use, and the projections are constituted by a member formed to have the projections arranged at intervals (A) from each other in a plane direction of the cleaning surface , characterized in that the member has a hardness of 0.4 MPa or more measured by a nano-indentation method, and the cleaning surface further comprises adhesive recesses that have higher adhesive force than that of the member and are exposed on the cleaning surface .
Headphones , comprising: a left earpiece ; a right earpiece ; and a headband assembly extending between the left and right earpieces, the headband assembly comprising: a frame defining a central opening and having first and second segments spaced apart from each other in an opposing relationship between left and right frame sides and a central frame region between the first and second segments and the left and right frame sides and elevated relative to the left and right frame sides; a signal cable electrically coupling the left and right earpieces and extending through an interior volume defined by the frame, and a mesh extending across the central opening between the opposing first and second segments of the central frame region and also between the left and right frame sides, the mesh having a curved profile between the left and right frame sides, characterized in that the mesh has a U-shaped cross-section between the first and second segments such that a central region of the mesh is positioned below the first and second segments in the central frame region and above the left and right frame sides. a left earpiece ; a right earpiece ; and a headband assembly extending between the left and right earpieces, the headband assembly comprising: a frame defining a central opening and having first and second segments spaced apart from each other in an opposing relationship between left and right frame sides and a central frame region between the first and second segments and the left and right frame sides and elevated relative to the left and right frame sides; a signal cable electrically coupling the left and right earpieces and extending through an interior volume defined by the frame, and a mesh extending across the central opening between the opposing first and second segments of the central frame region and also between the left and right frame sides, the mesh having a curved profile between the left and right frame sides, characterized in that the mesh has a U-shaped cross-section between the first and second segments such that a central region of the mesh is positioned below the first and second segments in the central frame region and above the left and right frame sides. a frame defining a central opening and having first and second segments spaced apart from each other in an opposing relationship between left and right frame sides and a central frame region between the first and second segments and the left and right frame sides and elevated relative to the left and right frame sides; a signal cable electrically coupling the left and right earpieces and extending through an interior volume defined by the frame, and a mesh extending across the central opening between the opposing first and second segments of the central frame region and also between the left and right frame sides, the mesh having a curved profile between the left and right frame sides, characterized in that the mesh has a U-shaped cross-section between the first and second segments such that a central region of the mesh is positioned below the first and second segments in the central frame region and above the left and right frame sides.
A semiconductor device, comprising: a first case and a second case , the first case and second case defining an inner space; a substrate in the inner space; at least one electronic component on the substrate ; and a heat dissipation chamber assembly between the substrate and at least a portion of the first case , the heat dissipation chamber assembly including a heat diffusion chamber in thermal contact with and overlapping the at least one electronic component , a chamber plate ,and a sidewall structure extending vertically toward the substrate and surrounding the at least one electronic component , characterized in that the first case includes a base plate , the chamber plate is hermetically connected to the base plate of the first case , and the heat diffusion chamber is defined by the chamber plate and the base plate of the first case . a first case and a second case , the first case and second case defining an inner space; a substrate in the inner space; at least one electronic component on the substrate ; and a heat dissipation chamber assembly between the substrate and at least a portion of the first case , the heat dissipation chamber assembly including a heat diffusion chamber in thermal contact with and overlapping the at least one electronic component , a chamber plate ,and a sidewall structure extending vertically toward the substrate and surrounding the at least one electronic component , a heat diffusion chamber in thermal contact with and overlapping the at least one electronic component , a chamber plate ,and a sidewall structure extending vertically toward the substrate and surrounding the at least one electronic component , characterized in that the first case includes a base plate , the chamber plate is hermetically connected to the base plate of the first case , and the heat diffusion chamber is defined by the chamber plate and the base plate of the first case . the first case includes a base plate , the chamber plate is hermetically connected to the base plate of the first case , and the heat diffusion chamber is defined by the chamber plate and the base plate of the first case .