mhurhangee/patent-ind-claim-en huggingface dataset:
A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein Ring A is Ring B is wherein Ring B is optionally substituted with up to 4 fluorine atoms, up to two OH or up to two C 1-4 alkyl which is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two OC 1-2 alkyl groups; Ring C is a cyclohexane ring; X is -NH-, -O-, or -OC 1-4 alkyl-; each of R 1 and R 2 is, independently, hydrogen, -C(O)NHR 4 , -C(O)OR 4 , -NHC(O)R 4 , -NHC(O)OR 4 , -NHC(O)NHR 4 , -NHS(O) 2 R 4 , -C 0-4 alkyl-NHR 4 , or -OR 4 , wherein R 1 and R 2 cannot simultaneously be hydrogen, and wherein R 1 and R 2 and the intervening carbon atom can form a dioxane or dioxolane ring; R 3 is hydrogen, -C 1-4 alkyl, fluoro, chloro, -OC 1-2 alkyl, -C(O)H, -C(O)OH, -C(O)OC 1-2 alkyl, - CN, -C(o)NHC 1-2 alkyl, or -C(O)NH 2 , wherein each of said R 3 alkyl is optionally substituted with up to 3 fluorine atoms, up to two OH, or up to two OC 1-2 alkyl groups; R 4 is hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-5 cycloalkyl, phenyl, pyrrole, imidazole, pyrazole, triazole, thiazole, isothiazole, oxazole, pyridine, pyrimidine, pyrimidinone, pyrazine, pyridazine, quinoline, oxetane, tetrahydrofuran, tetrahydropyran, dihydroisoxazole, pyrimidine-2,4 -dione, dihydrofuropyrimidine, dihydropyranopyrimidine, dihydropyrrolopyrimidine, tetrahydropteridine, or tetrahydropyridopyrimidine, wherein each of said R 4 groups is optionally substituted with up to four Br, Cl, F, or C 1-4 alkyl, up to three CN, NO 2 , C 2-4 alkenyl, C 2-4 alkynyl, C 3- 6 cycloalkyl, C 0-4 alkyl-C 3-5 cycloalkyl, C 0-4 alkyl-O-C 1-4 alkyl, C 0-4 alkyl-O-C 0-4 alkyl-C 3-5 cycloalkyl, C(O)OC 1-4 alkyl, C(O)OC 0-4 alkyl-C 3-5 cycloalkyl, C 0-4 alkyl-C(O)NH 2 , C(O)NHC 1-4 alkyl, C(O)N(C 1-4 alkyl) 2 , C(O)NH(C 0-4 alkyl-C 3-5 cycloalkyl), CH 2 OR 5 , C 0-4 alkyl-C(O)R 5 , C 0-4 alkyl-C(O)N(R 5 ) 2 , C 0-4 alkyl-C(O)OR 5 , C 0-4 alkyl-NHC(O)R 5 , C 0-4 alkyl-N(R 5 ) 2 , oxetane, azetidine, tetrahydrofuran, dihydropyran, tetrahydropyran, morpholine, piperidine, pyrrolidine, piperazine, furan, oxazole, oxadiazole, pyrrole, pyrazole, triazole, oxadiazole, tetrazole, or up to two OR 5 , wherein each of said optional R 4 substituents is optionally substituted with up to four fluorine atoms, up to two C 1-4 alkyl groups, up to two OH groups, up to two OC 1-4 alkyl groups, up to two SC 1-4 alkyl groups, a C(O)C 1-4 alkyl, a C(O)OC 1-4 alkyl, or a C(O)OC 0-4 alkyl-C 3-5 cycloalkyl; and each R 5 is, independently, hydrogen, C 1-4 alkyl, imidazole, triazole, thiazole, pyridine, pyrimidine, oxetane, tetrahydrofuran, or tetrahydropyran, and each R 5 group is optionally substituted with chloro, up to three fluorine atoms, up to two C 1-2 alkyl, CH 2 OR, CN, up to two OH, up to two OC 1-2 alkyl, a spirooxetane, pyrrolidine, or triazole, or two R 5 groups together with the intervening nitrogen atom form a morpholine ring, azetidine ring, pyrrolidine ring, piperidine ring, or piperazine ring.
A method of manufacturing a universal joint, the method characterized by comprising: temporarily assembling a bearing , which supports a shaft portion of a joint spider such that the shaft portion is rotatable, with respect to a through-hole and the shaft portion by press-fitting the bearing to a first position (P1) in the through-hole of a yoke (110; 210); and clinching, after the bearing is temporarily assembled, a portion of the yoke (110; 210) around the through-hole , and pressing the bearing deeper into the through-hole with a clinched portion formed by the clinching to press-fit the bearing to a second position (P2) located deeper than the first position (P1) in the through-hole . temporarily assembling a bearing , which supports a shaft portion of a joint spider such that the shaft portion is rotatable, with respect to a through-hole and the shaft portion by press-fitting the bearing to a first position (P1) in the through-hole of a yoke (110; 210); and clinching, after the bearing is temporarily assembled, a portion of the yoke (110; 210) around the through-hole , and pressing the bearing deeper into the through-hole with a clinched portion formed by the clinching to press-fit the bearing to a second position (P2) located deeper than the first position (P1) in the through-hole .
A system comprising a multifunctional tool and a tool clip , wherein the multifunctional tool comprises: I) a tool tip , said tool tip comprising a) a tool tip stator , and b) a tool tip rotor rotatable about a first axis (A) relative to said tool tip stator ; and II) a tool holder capable of removably engaging said tool tip , said tool holder comprising a collet , a tool tip locker, a motive source comprising a single motor ; said multifunctional tool characterized in that it further comprises a selector mechanism, and wherein when said tool holder engages said tool tip , i) said tool tip locker restricts rotational and axial movement about said first axis ( A ) of said tool tip stator relative to said collet , ii) said selector mechanism can be engaged to allow said motor to rotate the entire tool tip about said first axis ( A ) relative to said tool tip stator or to actuate the tool tip ; and and wherein the tool clip is configured for storing said tool tips when they are not engaged to the tool holder . I) a tool tip , said tool tip comprising a) a tool tip stator , and b) a tool tip rotor rotatable about a first axis (A) relative to said tool tip stator ; and a) a tool tip stator , and b) a tool tip rotor rotatable about a first axis (A) relative to said tool tip stator ; and II) a tool holder capable of removably engaging said tool tip , said tool holder comprising a collet , a tool tip locker, a motive source comprising a single motor ; said multifunctional tool characterized in that it further comprises a selector mechanism, and wherein when said tool holder engages said tool tip , i) said tool tip locker restricts rotational and axial movement about said first axis ( A ) of said tool tip stator relative to said collet , ii) said selector mechanism can be engaged to allow said motor to rotate the entire tool tip about said first axis ( A ) relative to said tool tip stator or to actuate the tool tip ; and and wherein the tool clip is configured for storing said tool tips when they are not engaged to the tool holder . a collet , a tool tip locker, a motive source comprising a single motor ; said multifunctional tool characterized in that it further comprises a selector mechanism, and wherein when said tool holder engages said tool tip , i) said tool tip locker restricts rotational and axial movement about said first axis ( A ) of said tool tip stator relative to said collet , ii) said selector mechanism can be engaged to allow said motor to rotate the entire tool tip about said first axis ( A ) relative to said tool tip stator or to actuate the tool tip ; and and wherein the tool clip is configured for storing said tool tips when they are not engaged to the tool holder . i) said tool tip locker restricts rotational and axial movement about said first axis ( A ) of said tool tip stator relative to said collet , ii) said selector mechanism can be engaged to allow said motor to rotate the entire tool tip about said first axis ( A ) relative to said tool tip stator or to actuate the tool tip ; and and wherein the tool clip is configured for storing said tool tips when they are not engaged to the tool holder .
An adhesive device for constructing segmented rotor blades comprising at least three prefabricated rotor blade parts, namely nose shell , middle part segment , and rear edge segment , exhibiting: a first accommodating region for receiving the prefabricated nose shell , a second accommodating region for receiving the prefabricated middle part segment and a third accommodating region for receiving the prefabricated rear edge segment , wherein the first accommodating region , the second accommodating region and the third accommodating region can be moved relative to each other such that, after the three prefabricated rotor blade parts have been accommodated in the intended accommodating regions in an open position of the adhesive device , these rotor blade parts can be brought into direct or indirect contact with each other via predetermined adhesion regions and thus transferred to an adhesion position, wherein a second retaining structure for the second accommodating region is provided between a first retaining structure for the first accommodating region and a third retaining structure for the third accommodating region , characterized in that the first retaining structure with the first accommodating region and the nose shell as well as the third retaining structure with the third accommodating region and the rear edge segment can be moved toward the middle part segment received in the second accommodating region , while the second accommodating region with the middle part segment remains spatially fixed in place.
An underwater hydrocarbon processing facility, the facility (1; 32; 42) comprising at least one cluster (3a, 3b; 3c; 33; 43) for process fluids including liquids and/or gases deriving from hydrocarbon extraction process, the cluster (3a, 3b; 3c; 33; 43) comprising: - at least two modules (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47), each comprising one fluid processing device and a plurality of first connection members for defining the inlet and the outlet of the process fluids; and - an interconnection unit (8; 16; 38; 48) configured to be set on the bed of the body of water and including a plurality of second connection members defining inlet and outlet for the process fluids and configured to be operatively coupled to a corresponding first connection members for operatively interconnecting said modules (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47); wherein the interconnection unit (8; 16; 38; 48) comprises at least one subsea control module for controlling the modules (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47) and each module (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47) comprises a further subsea control module for controlling parameters correlated to the respective process; the subsea control module having the function of master and being connected to an umbilical and to all further subsea control modules having the function of slave. - at least two modules (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47), each comprising one fluid processing device and a plurality of first connection members for defining the inlet and the outlet of the process fluids; and - an interconnection unit (8; 16; 38; 48) configured to be set on the bed of the body of water and including a plurality of second connection members defining inlet and outlet for the process fluids and configured to be operatively coupled to a corresponding first connection members for operatively interconnecting said modules (4, 5, 6, 7; 15, 16, 17, 18; 34, 35, 36, 37; 44, 45, 46, 47);
Assembly of - a swimming pool floor adjustable in a height direction relative to a pool bottom of a swimming pool , the adjustable pool floor having a top side and a bottom side facing away from each other, and wherein the adjustable pool floor is provided with at least one passage for letting water through, the passage opening out to at least the top side; and - a water distribution system comprising a water distribution conduit and at least one water inlet and at least one water outlet in fluid connection with the conduit, wherein in use the water outlet is fluidly connected to the passage of the adjustable pool floor, characterized in that in use the water inlet is in fluid connection with a water treatment system such that in use, the water flow goes from the water inlet to the water outlet of the water distribution system and through the passage in the adjustable pool floor into a volume of the swimming pool above the adjustable pool floor. - a swimming pool floor adjustable in a height direction relative to a pool bottom of a swimming pool , the adjustable pool floor having a top side and a bottom side facing away from each other, and wherein the adjustable pool floor is provided with at least one passage for letting water through, the passage opening out to at least the top side; and - a water distribution system comprising a water distribution conduit and at least one water inlet and at least one water outlet in fluid connection with the conduit, wherein in use the water outlet is fluidly connected to the passage of the adjustable pool floor, characterized in that in use the water inlet is in fluid connection with a water treatment system such that in use, the water flow goes from the water inlet to the water outlet of the water distribution system and through the passage in the adjustable pool floor into a volume of the swimming pool above the adjustable pool floor.
A curable silicone composition comprising: (A) 100 parts by weight of a linear organopolysiloxane having at least two silicon atom-bonded alkenyl groups per molecule, wherein at least 5 mole% of all silicon atom-bonded organic groups are aryl groups; (B) 1 to 100 parts by weight of an organopolysiloxane containing siloxane units represented by the formula: R 1 3 SiO 1/2 (wherein R 1 represents the same or different monovalent hydrocarbon group) and siloxane units represented by the formula: SiO 4/2 , wherein the amount of alkenyl groups is at least 6 % by weight; (C) an organopolysiloxane having at least two silicon tom-bonded hydrogen atoms per molecule, in an amount that the silicon atom-bonded hydrogen atoms in the component is 0.1 to 10 moles with regard to 1 mole of the total alkenyl groups included in components (A) and (B); and (D) a hydrosilylation reaction catalyst, in an amount that promotes curing of the composition. (A) 100 parts by weight of a linear organopolysiloxane having at least two silicon atom-bonded alkenyl groups per molecule, wherein at least 5 mole% of all silicon atom-bonded organic groups are aryl groups; (B) 1 to 100 parts by weight of an organopolysiloxane containing siloxane units represented by the formula: R 1 3 SiO 1/2 (wherein R 1 represents the same or different monovalent hydrocarbon group) and siloxane units represented by the formula: SiO 4/2 , wherein the amount of alkenyl groups is at least 6 % by weight; (C) an organopolysiloxane having at least two silicon tom-bonded hydrogen atoms per molecule, in an amount that the silicon atom-bonded hydrogen atoms in the component is 0.1 to 10 moles with regard to 1 mole of the total alkenyl groups included in components (A) and (B); and (D) a hydrosilylation reaction catalyst, in an amount that promotes curing of the composition.
A photovoltaic system comprising an inverter , photovoltaic modules , a photovoltaic generator , and a controller wherein the inverter is adapted to convert a DC power supplied by photovoltaic modules of the photovoltaic generator via power cables to said inverter into an AC current for an AC power supply grid , wherein the inverter has a base station connected by means of the power cables to module level devices which are provided to monitor and/or to control associated photovoltaic modules of the photovoltaic generator , wherein if the inverter does not receive sufficient energy from the photovoltaic generator and the AC power supply grid , the controller is adapted to activate a deadlock prevention mode of an energy supply unit connected to the inverter where the inverter receives energy from the energy supply unit such that the base station of the inverter is able to continue to transmit permission to operate, PTO, signals via the power cables to the module level devices of the photovoltaic generator , wherein the energy supply unit of the photovoltaic system can be switched by the controller into different operation modes, characterized in that the energy supply unit is configured to uses state of charge, SoC, levels for controlling the operation modes of the energy supply unit , and the SoC levels are stored in configuration registers of the controller . an inverter , photovoltaic modules , a photovoltaic generator , and a controller wherein the inverter is adapted to convert a DC power supplied by photovoltaic modules of the photovoltaic generator via power cables to said inverter into an AC current for an AC power supply grid , wherein the inverter has a base station connected by means of the power cables to module level devices which are provided to monitor and/or to control associated photovoltaic modules of the photovoltaic generator , wherein if the inverter does not receive sufficient energy from the photovoltaic generator and the AC power supply grid , the controller is adapted to activate a deadlock prevention mode of an energy supply unit connected to the inverter where the inverter receives energy from the energy supply unit such that the base station of the inverter is able to continue to transmit permission to operate, PTO, signals via the power cables to the module level devices of the photovoltaic generator , wherein the energy supply unit of the photovoltaic system can be switched by the controller into different operation modes, characterized in that the energy supply unit is configured to uses state of charge, SoC, levels for controlling the operation modes of the energy supply unit , and the SoC levels are stored in configuration registers of the controller .
A compound of formula (I) or pharmaceutically acceptable salt thereof: wherein, X is nitrogen, Y and Z are carbon; R 1 is phenyl, pyridine, or pyrimidine substituted or unsubstituted with one or more substituents selected from the group consisting of hydroxy, amino and halogen; R 2 is hydrogen; and R 3 is pyrimidine substituted or unsubstituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 10 heterocycloalkyl, amino, C 1 -C 6 alkylamino and halogen. X is nitrogen, Y and Z are carbon; R 1 is phenyl, pyridine, or pyrimidine substituted or unsubstituted with one or more substituents selected from the group consisting of hydroxy, amino and halogen; R 2 is hydrogen; and R 3 is pyrimidine substituted or unsubstituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 10 heterocycloalkyl, amino, C 1 -C 6 alkylamino and halogen.
A method for determining a roadway condition by means of steering actuators, wherein the at least two steering actuators are each arranged on a vehicle wheel associated with the same vehicle axle, comprising the following steps: - detecting a measurement variable of the first steering actuator; - detecting a measurement variable of the second steering actuator; - comparing the detected measurement variables of the two steering actuators; characterised by - determining an inhomogeneity signal from the deviation between the detected measurement variables of the two steering actuators, wherein a inhomogeneity signal lying within a tolerance range represents a homogeneous roadway condition and a inhomogeneity signal lying outside the tolerance range represents an inhomogeneous roadway condition. - detecting a measurement variable of the first steering actuator; - detecting a measurement variable of the second steering actuator; - comparing the detected measurement variables of the two steering actuators; characterised by - determining an inhomogeneity signal from the deviation between the detected measurement variables of the two steering actuators, wherein a inhomogeneity signal lying within a tolerance range represents a homogeneous roadway condition and a inhomogeneity signal lying outside the tolerance range represents an inhomogeneous roadway condition.
A composition comprising a soluble TLR2 moiety for use for treating or preventing one or more viral or bacterial infections in the respiratory tract of a subj ect, wherein the TLR2 moiety comprises a TLR2 agonist conjugated to a solubilising agent, wherein the agent is PEG, wherein the TLR2 agonist comprises a lipid moiety selected from the group consisting of palmitolyl, myristroyl, steareoyl, lauroyl, decanoyl and combinations thereof, wherein the composition does not induce a specific humoral or cellular immune response directed against an agent that causes the infection mentioned above, and does not comprise an antigen that can elicit an immune response against an agent that causes the infection mentioned above, and wherein the composition is administered intranasally or orally to the respiratory tract. wherein the TLR2 moiety comprises a TLR2 agonist conjugated to a solubilising agent, wherein the agent is PEG, wherein the TLR2 agonist comprises a lipid moiety selected from the group consisting of palmitolyl, myristroyl, steareoyl, lauroyl, decanoyl and combinations thereof, wherein the composition does not induce a specific humoral or cellular immune response directed against an agent that causes the infection mentioned above, and does not comprise an antigen that can elicit an immune response against an agent that causes the infection mentioned above, and wherein the composition is administered intranasally or orally to the respiratory tract.
A method of making a magnesium aluminate spinel including an alumina compound and a magnesium compound, the method including the steps of: a) dispersing the alumina compound in an aqueous solution, to form an alumina dispersion, the aqueous solution having a pH of between 2 and 5; b) flocculating the alumina dispersion by adding a base to increase the pH of the alumina dispersion to a pH of between 8 and 10; c) adding the alumina dispersion to an aqueous dispersion of the magnesium compound to form a slurry; d) drying the slurry to produce a dried spinel precursor; and e) calcining the dried spinel precursor to produce the magnesium aluminate spinel. a) dispersing the alumina compound in an aqueous solution, to form an alumina dispersion, the aqueous solution having a pH of between 2 and 5; b) flocculating the alumina dispersion by adding a base to increase the pH of the alumina dispersion to a pH of between 8 and 10; c) adding the alumina dispersion to an aqueous dispersion of the magnesium compound to form a slurry; d) drying the slurry to produce a dried spinel precursor; and e) calcining the dried spinel precursor to produce the magnesium aluminate spinel.