A mechanical thrombectomy apparatus , comprising: a thrombus removal head , connected to a sheath connector through a sheath ; a thrombus fragmentation system, comprising a rotation actuator , a transmission tube , and a thrombus fragmentation cutter , wherein a proximal end of the transmission tube is connected to the rotation actuator , a distal end of the transmission tube is connected to the thrombus fragmentation cutter , and the transmission tube extends into the thrombus removal head along lumens of the sheath connector and the sheath ; when driven by the rotation actuator , the transmission tube is able to rotate and drive the thrombus fragmentation cutter to rotate, so as to fragment a thrombus aspirated into the thrombus removal head ; a thrombus aspiration system, comprising an aspiration device and a thrombus aspiration tube, wherein a proximal end of the thrombus aspiration tube is connected to the aspiration device, and a distal end of the thrombus aspiration tube is connected to the sheath connector ; a cavity formed between the transmission tube and the sheath is communicated with the thrombus aspiration tube to form a thrombus aspiration lumen; and a drug perfusion system, comprising an injector and an infusion tube , a proximal end of the infusion tube is connected to the injector , a distal end of the infusion tube is communicated with the transmission tube to allow a drug to pass through the transmission tube and the thrombus removal head to reach a site of a thrombus; wherein the aspiration device is a peristaltic pump , and the thrombus aspiration tube is a flexible tube ; and wherein the thrombus removal head has a distal end that has a tapered structure and has at least one inclined hole and a top hole , and the inclined hole and the top hole are configured so that the drug is allowed be perfused therethrough; and wherein the top hole is formed at a tip of the tapered structure. a thrombus removal head , connected to a sheath connector through a sheath ; a thrombus fragmentation system, comprising a rotation actuator , a transmission tube , and a thrombus fragmentation cutter , wherein a proximal end of the transmission tube is connected to the rotation actuator , a distal end of the transmission tube is connected to the thrombus fragmentation cutter , and the transmission tube extends into the thrombus removal head along lumens of the sheath connector and the sheath ; when driven by the rotation actuator , the transmission tube is able to rotate and drive the thrombus fragmentation cutter to rotate, so as to fragment a thrombus aspirated into the thrombus removal head ; a thrombus aspiration system, comprising an aspiration device and a thrombus aspiration tube, wherein a proximal end of the thrombus aspiration tube is connected to the aspiration device, and a distal end of the thrombus aspiration tube is connected to the sheath connector ; a cavity formed between the transmission tube and the sheath is communicated with the thrombus aspiration tube to form a thrombus aspiration lumen; and a drug perfusion system, comprising an injector and an infusion tube , a proximal end of the infusion tube is connected to the injector , a distal end of the infusion tube is communicated with the transmission tube to allow a drug to pass through the transmission tube and the thrombus removal head to reach a site of a thrombus; wherein the aspiration device is a peristaltic pump , and the thrombus aspiration tube is a flexible tube ; and wherein the thrombus removal head has a distal end that has a tapered structure and has at least one inclined hole and a top hole , and the inclined hole and the top hole are configured so that the drug is allowed be perfused therethrough; and wherein the top hole is formed at a tip of the tapered structure. <EOS>