A method of single cell analysis, comprising: a) contacting a cell with a reporter agent comprising a reporter nucleic acid molecule to provide a labelled cell, wherein the reporter nucleic acid molecule comprises a reporter sequence corresponding to the reporter agent, wherein the labelled cell comprises a complex coupled to a surface of the cell, and wherein the complex comprises (i) a capture agent, (ii) a secreted analyte, and (iii) the reporter agent, wherein the capture agent is configured to couple to both a cell surface molecule and the secreted analyte, and wherein the reporter agent is configured to couple to the secreted analyte; b) partitioning the labelled cell into a partition, wherein the partition is from a plurality of partitions and is a droplet or a microwell, wherein the partition comprises a plurality of barcode nucleic acid molecules which comprise a plurality of partition barcode sequences, wherein said reporter nucleic acid molecule further comprises a sequence configured to couple to the barcode nucleic acid molecule; c) in bulk or in the partition, generating a barcoded nucleic acid molecule from a barcode nucleic acid molecule of the plurality of barcode nucleic acid molecules and the reporter nucleic acid molecule, wherein the barcoded nucleic acid molecule comprises the reporter sequence or a complement thereof and a partition barcode sequence or a complement thereof; and d) sequencing the barcoded nucleic acid molecules to obtain a nucleic acid sequence of the barcoded nucleic acid molecule, optionally wherein the barcoded nucleic acid molecules are amplified prior to sequencing. a) contacting a cell with a reporter agent comprising a reporter nucleic acid molecule to provide a labelled cell, wherein the reporter nucleic acid molecule comprises a reporter sequence corresponding to the reporter agent, wherein the labelled cell comprises a complex coupled to a surface of the cell, and wherein the complex comprises (i) a capture agent, (ii) a secreted analyte, and (iii) the reporter agent, wherein the capture agent is configured to couple to both a cell surface molecule and the secreted analyte, and wherein the reporter agent is configured to couple to the secreted analyte; b) partitioning the labelled cell into a partition, wherein the partition is from a plurality of partitions and is a droplet or a microwell, wherein the partition comprises a plurality of barcode nucleic acid molecules which comprise a plurality of partition barcode sequences, wherein said reporter nucleic acid molecule further comprises a sequence configured to couple to the barcode nucleic acid molecule; c) in bulk or in the partition, generating a barcoded nucleic acid molecule from a barcode nucleic acid molecule of the plurality of barcode nucleic acid molecules and the reporter nucleic acid molecule, wherein the barcoded nucleic acid molecule comprises the reporter sequence or a complement thereof and a partition barcode sequence or a complement thereof; and d) sequencing the barcoded nucleic acid molecules to obtain a nucleic acid sequence of the barcoded nucleic acid molecule, optionally wherein the barcoded nucleic acid molecules are amplified prior to sequencing. <EOS>