mhurhangee/patent-ind-claim-en huggingface dataset:
A stable liquid pharmaceutical multi-dose formulation, the formulation comprising a glucagon-like peptide 2 (GLP-2) analogue, wherein the GLP-2 analogue is represented by the formula: R 1 -Z 1 -His-Gly-Glu-Gly-X5-Phe-Ser-Ser-Glu-Leu-X11-Thr-Ile-Leu-Asp-Ala-Leu- Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Z 2 -R 2 wherein: R 1 is hydrogen, C 1-4 alkyl (e.g. methyl), acetyl, formyl, benzoyl or trifluoroacetyl; X5 is Ser or Thr; X11 is Ala or Ser; R 2 is NH 2 or OH; and Z 1 and Z 2 are independently absent or a peptide sequence of 1-6 amino acid units of Lys; or a pharmaceutically acceptable salt or derivative thereof; wherein the formulation comprises: (a) the GLP-2 analogue at a concentration of about 1 mg/mL to about 30 mg/mL; (b) meta-cresol or phenol as a preservative at a concentration of 1.0 to 5.0 mg/mL; (c) a buffer selected from the group consisting of a histidine buffer, mesylate buffer, acetate buffer, glycine buffer, lysine buffer, TRIS buffer, Bis-Tris buffer and MOPS buffer, the buffer being present at a concentration of about 5 mM to about 50 mM; (d) a non-ionic tonicity modifier selected from the group consisting of mannitol, sucrose, glycerol, sorbitol and trehalose at a concentration of about 20 mM to about 360 mM; (e) a pH of about 5.0 to about 6.8. R 1 is hydrogen, C 1-4 alkyl (e.g. methyl), acetyl, formyl, benzoyl or trifluoroacetyl; X5 is Ser or Thr; X11 is Ala or Ser; R 2 is NH 2 or OH; and Z 1 and Z 2 are independently absent or a peptide sequence of 1-6 amino acid units of Lys; or a pharmaceutically acceptable salt or derivative thereof; wherein the formulation comprises: (a) the GLP-2 analogue at a concentration of about 1 mg/mL to about 30 mg/mL; (b) meta-cresol or phenol as a preservative at a concentration of 1.0 to 5.0 mg/mL; (c) a buffer selected from the group consisting of a histidine buffer, mesylate buffer, acetate buffer, glycine buffer, lysine buffer, TRIS buffer, Bis-Tris buffer and MOPS buffer, the buffer being present at a concentration of about 5 mM to about 50 mM; (d) a non-ionic tonicity modifier selected from the group consisting of mannitol, sucrose, glycerol, sorbitol and trehalose at a concentration of about 20 mM to about 360 mM; (e) a pH of about 5.0 to about 6.8. (a) the GLP-2 analogue at a concentration of about 1 mg/mL to about 30 mg/mL; (b) meta-cresol or phenol as a preservative at a concentration of 1.0 to 5.0 mg/mL; (c) a buffer selected from the group consisting of a histidine buffer, mesylate buffer, acetate buffer, glycine buffer, lysine buffer, TRIS buffer, Bis-Tris buffer and MOPS buffer, the buffer being present at a concentration of about 5 mM to about 50 mM; (d) a non-ionic tonicity modifier selected from the group consisting of mannitol, sucrose, glycerol, sorbitol and trehalose at a concentration of about 20 mM to about 360 mM; (e) a pH of about 5.0 to about 6.8.
A method for monitoring combustion of a natural gas burner at a combustion controller , the method comprising: acquiring a measurement result for natural gas in a gas supply line of the natural gas burner , wherein the measurement result comprises a gas component in the natural gas and a corresponding content; inputting the measurement result into a preset control model, to determine control information corresponding to the measurement result, wherein the control model is related to the gas component in the natural gas and the corresponding content; adjusting a flow rate of natural gas in the gas supply line of the natural gas burner according to the control information; and characterized in that the method further comprises: acquiring a dynamic signal of a dynamic sensor of the natural gas burner , an emission signal of an emission sensor and a temperature signal of a temperature sensor , to serve as a feedback signal; and in that the step of determining control information comprises: inputting the measurement result and the feedback signal into the preset control model, to acquire control information corresponding to the measurement result and the feedback signal, wherein the control model is related to the gas component in the natural gas and the corresponding content, and the feedback signal. acquiring a measurement result for natural gas in a gas supply line of the natural gas burner , wherein the measurement result comprises a gas component in the natural gas and a corresponding content; inputting the measurement result into a preset control model, to determine control information corresponding to the measurement result, wherein the control model is related to the gas component in the natural gas and the corresponding content; adjusting a flow rate of natural gas in the gas supply line of the natural gas burner according to the control information; and acquiring a dynamic signal of a dynamic sensor of the natural gas burner , an emission signal of an emission sensor and a temperature signal of a temperature sensor , to serve as a feedback signal; and in that the step of determining control information comprises: inputting the measurement result and the feedback signal into the preset control model, to acquire control information corresponding to the measurement result and the feedback signal, wherein the control model is related to the gas component in the natural gas and the corresponding content, and the feedback signal.
A combustor for use in a gas turbine engine , the combustor comprising: a heat shield panel having a first surface , a second surface opposite the first surface , and a plurality of effusion apertures extending from the second surface to the first surface ; and a combustor shell having an inner surface and an outer surface opposite the inner surface , the inner surface of the combustor shell and the second surface of the heat shield panel being in a facing spaced relationship defining an impingement cavity therebetween, wherein the combustor shell comprises a plurality of impingement apertures that have a nonaxisymmetric shape, each of the impingement apertures extending from the outer surface to the inner surface through the combustor shell , and each of the plurality of impingement apertures are configured to disperse particulate on the second surface of the heat shield panel , characterised in that : each of the plurality of impingement apertures is comma-shaped, wherein the comma shape is defined by one curved wall and one linear wall , the linear wall extending from a first end of the curved wall to a second end of the curved wall and the curved wall and linear wall extend from the outer surface to the inner surface through the combustor shell . a heat shield panel having a first surface , a second surface opposite the first surface , and a plurality of effusion apertures extending from the second surface to the first surface ; and a combustor shell having an inner surface and an outer surface opposite the inner surface , the inner surface of the combustor shell and the second surface of the heat shield panel being in a facing spaced relationship defining an impingement cavity therebetween, wherein the combustor shell comprises a plurality of impingement apertures that have a nonaxisymmetric shape, each of the impingement apertures extending from the outer surface to the inner surface through the combustor shell , and each of the plurality of impingement apertures are configured to disperse particulate on the second surface of the heat shield panel , characterised in that : each of the plurality of impingement apertures is comma-shaped,
A pool cleaning robot , comprising: a filtering unit for filtering fluid that passes through the filtering unit; and a controller that is configured to at least assist in determining, based on the cleanliness related parameter of the filtering unit, a cleanliness of the filtering unit, wherein the pool cleaning robot is characterized by further comprising: a calorimetric sensor for sensing a cleanliness related parameter of the filtering unit while the pool cleaning robot is submerged in the fluid, and wherein at least one of the following is true: (i) the pool cleaning robot comprises a turbulence generator that is arranged to introduce turbulences that contact the calorimetric sensor; (ii) the pool cleaning robot comprises flow limiters that are arranged to limit a flow of side flows over the calorimetric sensor; (iii) the calorimetric sensor consists essentially of a single thermal resistor . a filtering unit for filtering fluid that passes through the filtering unit; and a controller that is configured to at least assist in determining, based on the cleanliness related parameter of the filtering unit, a cleanliness of the filtering unit, wherein the pool cleaning robot is characterized by further comprising: a calorimetric sensor for sensing a cleanliness related parameter of the filtering unit while the pool cleaning robot is submerged in the fluid, and wherein at least one of the following is true: (i) the pool cleaning robot comprises a turbulence generator that is arranged to introduce turbulences that contact the calorimetric sensor; (ii) the pool cleaning robot comprises flow limiters that are arranged to limit a flow of side flows over the calorimetric sensor; (iii) the calorimetric sensor consists essentially of a single thermal resistor . a calorimetric sensor for sensing a cleanliness related parameter of the filtering unit while the pool cleaning robot is submerged in the fluid, and wherein at least one of the following is true: (i) the pool cleaning robot comprises a turbulence generator that is arranged to introduce turbulences that contact the calorimetric sensor; (ii) the pool cleaning robot comprises flow limiters that are arranged to limit a flow of side flows over the calorimetric sensor; (iii) the calorimetric sensor consists essentially of a single thermal resistor . (i) the pool cleaning robot comprises a turbulence generator that is arranged to introduce turbulences that contact the calorimetric sensor; (ii) the pool cleaning robot comprises flow limiters that are arranged to limit a flow of side flows over the calorimetric sensor; (iii) the calorimetric sensor consists essentially of a single thermal resistor .
Power trainer device , having - a device frame , - a first actuating element and a second actuating element , - a force transmitter connecting the first and the second actuating element and having a flexible section which is displaceably guided over a deflection roller and whose limbs are each operatively connected to one of the actuating elements with respect to force flow, - a spring element , connected in a force-transmitting manner between the shaft of the deflection roller and the device frame , characterized in that - a lever mechanism and a pointer element are provided, wherein the lever mechanism converts a displacement of the shaft of the deflection roller into a deflection of the pointer element . - a device frame , - a first actuating element and a second actuating element , - a force transmitter connecting the first and the second actuating element and having a flexible section which is displaceably guided over a deflection roller and whose limbs are each operatively connected to one of the actuating elements with respect to force flow, - a spring element , connected in a force-transmitting manner between the shaft of the deflection roller and the device frame , characterized in that - a lever mechanism and a pointer element are provided, wherein the lever mechanism converts a displacement of the shaft of the deflection roller into a deflection of the pointer element .
A compound, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is selected from:
An actinic ray-sensitive or radiation-sensitive resin composition comprising: (A) a resin having a polarity that increases by an action of an acid; (B) a photoacid generator; and an anion (P) which is one or more anions selected from the group consisting of NO 3 - , SO 4 2- , Cl - , and Br - , and wherein the content of the anion (P) is from 0.01 ppb to 1 ppm with respect to the total mass of the actinic ray-sensitive or radiation-sensitive resin composition. (A) a resin having a polarity that increases by an action of an acid; (B) a photoacid generator; and an anion (P) which is one or more anions selected from the group consisting of NO 3 - , SO 4 2- , Cl - , and Br - , and wherein the content of the anion (P) is from 0.01 ppb to 1 ppm with respect to the total mass of the actinic ray-sensitive or radiation-sensitive resin composition.
Medicament delivery device comprising - a housing , which housing is arranged to accommodate a medicament container , - a drive unit operably arranged to act on a medicament container accommodated in said housing for expelling a dose of medicament, wherein the drive unit comprises a plunger rod , - a force element operably connected to said plunger rod to drive said plunger rod for expelling a dose of medicament, - a connector provided with a number of generally radially movable holding elements arranged to releasibly hold said plunger rod, - an actuator element operably arranged to said connector , and , arranged axially movable from a locking position to a release position of said holding elements and - a manually operable actuator arranged to act on said actuator element for releasing said connector when operated, - a safety device arranged to releasibly hold said actuator element in the locking position with said connector , preventing unintended release of said plunger rod , characterised in that said safety device comprises safety elements designed as a number of flexible arms protruding distally in a generally longitudinal direction towards said actuator element and arranged to prevent movement of said actuator element from said locking position to said release position until activated, and wherein the medicament delivery device further comprises an activator operably arranged to, upon manual operation, activate said safety device to allow movement of said actuator element . - a housing , which housing is arranged to accommodate a medicament container , - a drive unit operably arranged to act on a medicament container accommodated in said housing for expelling a dose of medicament, wherein the drive unit comprises a plunger rod , - a force element operably connected to said plunger rod to drive said plunger rod for expelling a dose of medicament, - a connector provided with a number of generally radially movable holding elements arranged to releasibly hold said plunger rod, - an actuator element operably arranged to said connector , and , arranged axially movable from a locking position to a release position of said holding elements and - a manually operable actuator arranged to act on said actuator element for releasing said connector when operated, - a safety device arranged to releasibly hold said actuator element in the locking position with said connector , preventing unintended release of said plunger rod ,
A drive device for a sliding door of a motor vehicle, comprising an output element rotatable about an axis of rotation by a drive motor , and an electromagnetic locking mechanism for locking the output element , wherein the locking mechanism comprises a friction element which has a magnetic material and which is supported at the output element in a rotationally fixed manner, but in a movable manner in the direction of the axis of rotation ; a fixed-position friction surface ; and an electromagnet which has a magnetic coil and a magnet body and by which the friction element can be brought into engagement with the friction surface to lock the output element , characterized in that the material of the friction element is magnetically soft, the magnet body comprises a ferromagnetic, magnetically hard material, and the deactivation of the electromagnet takes place by a pulsed alternating energization of the magnetic coil , wherein the holding force exerted by the electromagnet on the output element when the locking mechanism is activated is selected such that the sliding door is reliably held in an open position even on a downward incline, but it is still possible for a vehicle user to manually overcome the holding force and to manually move the sliding door. an output element rotatable about an axis of rotation by a drive motor , and an electromagnetic locking mechanism for locking the output element , wherein the locking mechanism comprises a friction element which has a magnetic material and which is supported at the output element in a rotationally fixed manner, but in a movable manner in the direction of the axis of rotation ; a fixed-position friction surface ; and an electromagnet which has a magnetic coil and a magnet body and by which the friction element can be brought into engagement with the friction surface to lock the output element , characterized in that the material of the friction element is magnetically soft, the magnet body comprises a ferromagnetic, magnetically hard material, and the deactivation of the electromagnet takes place by a pulsed alternating energization of the magnetic coil , wherein the holding force exerted by the electromagnet on the output element when the locking mechanism is activated is selected such that the sliding door is reliably held in an open position even on a downward incline, but it is still possible for a vehicle user to manually overcome the holding force and to manually move the sliding door.
Pallet container for storing and for transporting in particular flammable or combustible liquid contents, having a thin-walled rigid inner container made of thermoplastic material, having a tubular lattice frame which, in the form of a supporting casing, tightly encloses the inner plastic container and is made up of horizontal and vertical tubular bars which are welded to one another, wherein the inner plastic container is possibly enclosed by a fire-protection insulating mat , and having a floor pallet , on which the plastic container rests and to which the tubular lattice frame is solidly connected, wherein the floor pallet is of composite design with an upper carrying panel made of sheet steel, with upper steel tubes running parallel and diagonally directly beneath the carrying panel , with corner feet and midfeet , and with a floor-tube linkage which is made of steel tubing and runs all the way round beneath the corner feet and midfeet , characterized in that at least one midfoot comprises two separate sheet-steel parts, namely an outer midfoot part and an inner midfoot part , which are specifically formed by punching and bending such that, in the definitively installed state, they are fixed between the upper steel tubes and the all-round floor-tube linkage , wherein the two midfoot parts , plugged together with a plug-in fit, interengage in a form-fitting manner.
An air duct system , comprising: an air duct having a pliable sidewall having a tubular shape when installed, the pliable sidewall having a total weight; a framework disposed within the air duct , the framework comprising: a material of less flexibility than that of the pliable sidewall , a shaft , a length of the shaft being adjustable to enable the air duct to be placed in longitudinal tension while the shaft is in longitudinal compression; and a plurality of ribs coupled to the shaft , the ribs to engage an inner surface of the air duct ; and a plurality of hangers with one or more of the hangers comprising an elongate member having an upper section and a lower section , the upper section to be positioned above the air duct , the lower section to be coupled to the framework , and most of the total weight of the pliable sidewall carried by the framework when in an assembled state. an air duct having a pliable sidewall having a tubular shape when installed, the pliable sidewall having a total weight; a framework disposed within the air duct , the framework comprising: a material of less flexibility than that of the pliable sidewall , a shaft , a length of the shaft being adjustable to enable the air duct to be placed in longitudinal tension while the shaft is in longitudinal compression; and a plurality of ribs coupled to the shaft , the ribs to engage an inner surface of the air duct ; and a material of less flexibility than that of the pliable sidewall , a shaft , a length of the shaft being adjustable to enable the air duct to be placed in longitudinal tension while the shaft is in longitudinal compression; and a plurality of ribs coupled to the shaft , the ribs to engage an inner surface of the air duct ; and a plurality of hangers with one or more of the hangers comprising an elongate member having an upper section and a lower section , the upper section to be positioned above the air duct , the lower section to be coupled to the framework , and most of the total weight of the pliable sidewall carried by the framework when in an assembled state.
A method of sidelink positioning determination and communication, the method comprising: obtaining , at a first sidelink-enabled device , data from one or more data sources indicative of one or more criteria for using either Round-Trip Time, RTT,-based positioning of a target node or Single-Sided, SS,-based positioning of the target node; selecting , with the first sidelink-enabled device , a positioning type from the group consisting of RTT-based positioning and SS-based positioning, based on the data; and sending a message from the first sidelink-enabled device to a second sidelink-enabled device , wherein the message includes information indicative of the selected positioning type. obtaining , at a first sidelink-enabled device , data from one or more data sources indicative of one or more criteria for using either Round-Trip Time, RTT,-based positioning of a target node or Single-Sided, SS,-based positioning of the target node; selecting , with the first sidelink-enabled device , a positioning type from the group consisting of RTT-based positioning and SS-based positioning, based on the data; and sending a message from the first sidelink-enabled device to a second sidelink-enabled device , wherein the message includes information indicative of the selected positioning type.
Rail vehicle having a drive assembly , wherein the drive assembly has an internal combustion engine which by way of an intervening transmission acts on at least one drive axle of the rail vehicle, and having an electric motor which is able to be selectively switched on so as to act on a drive axle of the rail vehicle; wherein the electric motor is assigned an electric energy storage device in such a manner that the electric motor is able to be operated when the internal combustion engine is switched off; wherein the rail vehicle is designed as a rail-bound working machine, and has hydraulically-driven working equipment and a motor-driven hydraulic pump , characterized in that the electric motor in terms of force transmission is connectable to the hydraulic pump in such a manner that the working equipment in the case of a switched-off internal combustion engine is able to be operated by means of the electric motor , and in that the electric motor , in an operating mode referred to as "boost mode", is able to be switched on in addition to the internal combustion engine as a propulsion drive with an increased drive output.