A process for upgrading residuum hydrocarbons and decreasing tendency of the resulting products toward asphaltenic sediment formation in downstream processes, the process comprising: a) contacting a residuum hydrocarbon fraction (2; 52) and hydrogen with a hydroconversion catalyst in a hydrocracking reaction zone (6; 56) comprising one or more ebullated bed reactors to convert at least a portion of the residuum hydrocarbon fraction (2; 52) to lighter hydrocarbons; b) recovering an effluent from the hydrocracking reaction zone (6; 56); c) contacting hydrogen and at least a portion of the effluent (14; 42; 64) with a resid hydrotreating catalyst; and d) separating the effluent (14; 42; 64) to recover two or more hydrocarbon fractions (18, 20; 88, 90), wherein the contacting (c) and separating (d) comprise: contacting hydrogen and the effluent with a first resid hydrotreating catalyst in an upflow reactor ; recovering an effluent from the upflow reactor ; and feeding the effluent from the upflow reactor to a reactor / stripper to concurrently: separate the effluent to recover two or more hydrocarbon fractions comprising at least a heavy hydrocarbon fraction and a light hydrocarbon fraction ; contact hydrogen and the heavy hydrocarbon fraction with a second resid hydrotreating catalyst contained in a lower portion (B) of the reactor / stripper ; and contact hydrogen and the light hydrocarbon fraction with a distillate hydrotreating catalyst contained in an upper portion (A) of the reactor / stripper . a) contacting a residuum hydrocarbon fraction (2; 52) and hydrogen with a hydroconversion catalyst in a hydrocracking reaction zone (6; 56) comprising one or more ebullated bed reactors to convert at least a portion of the residuum hydrocarbon fraction (2; 52) to lighter hydrocarbons; b) recovering an effluent from the hydrocracking reaction zone (6; 56); c) contacting hydrogen and at least a portion of the effluent (14; 42; 64) with a resid hydrotreating catalyst; and d) separating the effluent (14; 42; 64) to recover two or more hydrocarbon fractions (18, 20; 88, 90), contacting hydrogen and the effluent with a first resid hydrotreating catalyst in an upflow reactor ; recovering an effluent from the upflow reactor ; and feeding the effluent from the upflow reactor to a reactor / stripper to concurrently: separate the effluent to recover two or more hydrocarbon fractions comprising at least a heavy hydrocarbon fraction and a light hydrocarbon fraction ; contact hydrogen and the heavy hydrocarbon fraction with a second resid hydrotreating catalyst contained in a lower portion (B) of the reactor / stripper ; and contact hydrogen and the light hydrocarbon fraction with a distillate hydrotreating catalyst contained in an upper portion (A) of the reactor / stripper . separate the effluent to recover two or more hydrocarbon fractions comprising at least a heavy hydrocarbon fraction and a light hydrocarbon fraction ; contact hydrogen and the heavy hydrocarbon fraction with a second resid hydrotreating catalyst contained in a lower portion (B) of the reactor / stripper ; and contact hydrogen and the light hydrocarbon fraction with a distillate hydrotreating catalyst contained in an upper portion (A) of the reactor / stripper . <EOS>