mhurhangee/patent-ind-claim-en huggingface dataset:
A pharmaceutical composition for inducing an immune response in a human or animal subject suffering from a pathologic disease or disorder, comprising autologous activated cytotoxic CD8+ T-lymphocytes (CTL), activated by autologous primed mature dendritic cells of the human or animal subject, said autologous primed mature dendritic cells presenting an antigenic peptide, - wherein the activated CTL are derived from an autologous population of peripheral blood mononuclear cells (PBMCs) isolated from peripheral blood of the same human or animal subject; and - wherein the activated CTL are able to recognize the antigenic peptide; - wherein the CTL have been activated by autologous dendritic cells primed with an antigenic peptide, wherein the dendritic cells have been isolated from the same human or animal subject as the CTL, wherein the CTL have been activated by co-culturing CD8+ T-cells derived from the population of PBMC, with the antigen-presenting dendritic cells; - and wherein the dendritic cells prior to their use in the activation of CD8+ T cells have been cultured ex vivo and subsequently have been primed (loaded, pulsed) with the antigenic peptide, and subsequently have been matured in the presence of a cytokine cocktail prior to their use in activation of the CD8+ T cells by co-culturing, characterized in that the antigenic peptide is a MUC (79-87) TLAPATEPA peptide (Seq. ID 1); and in that the CTL have been activated by co-culturing with the loaded mature dendritic cells a population of all non-adhering immune cells derived from the same population of PBMC as the population of which the dendritic cells have been derived, wherein said population of non-adherent immune cells, besides including the CD8+ T cells to be activated, further includes all of the following group of cells: CD4+ T-lymphocytes, B lymphocytes, platelets, neutrophils, basophils and eosinophils. - wherein the activated CTL are derived from an autologous population of peripheral blood mononuclear cells (PBMCs) isolated from peripheral blood of the same human or animal subject; and - wherein the activated CTL are able to recognize the antigenic peptide; - wherein the CTL have been activated by autologous dendritic cells primed with an antigenic peptide, wherein the dendritic cells have been isolated from the same human or animal subject as the CTL, wherein the CTL have been activated by co-culturing CD8+ T-cells derived from the population of PBMC, with the antigen-presenting dendritic cells; - and wherein the dendritic cells prior to their use in the activation of CD8+ T cells have been cultured ex vivo and subsequently have been primed (loaded, pulsed) with the antigenic peptide, and subsequently have been matured in the presence of a cytokine cocktail prior to their use in activation of the CD8+ T cells by co-culturing,
A pneumatic radial tire, the tire comprising: a pair of opposing bead areas , wherein each bead area includes a bead core and a bead apex ; at least one carcass reinforcing ply , the reinforcing ply including a turn up portion at each bead core , each turn up portion including a radially outward end ; a pair of chippers disposed axially inwardly of one or each turn up portion outward end , the pair of chippers including a first chipper and a second chipper ; wherein the first chipper is disposed axially inwardly of the respective bead apex and the second chipper is disposed axially outwardly of the first chipper and axially inwardly of the respective bead apex ; wherein an inboard surface of the second chipper is bonded to an outboard surface of the first chipper ; wherein a radially inward end of the first chipper is disposed radially outwardly of the bead core and the first chipper extends past the turn up portion radially outward end ; and wherein a radially inward end of the second chipper is disposed radially outwardly of the bead core and the second chipper extends past the turn up portion radially outward end ; characterized in that the radially inward end of the second chipper is disposed radially outwardly of the radially inward end of the first chipper by a radial distance of at least 5 millimeters. a pair of opposing bead areas , wherein each bead area includes a bead core and a bead apex ; at least one carcass reinforcing ply , the reinforcing ply including a turn up portion at each bead core , each turn up portion including a radially outward end ; a pair of chippers disposed axially inwardly of one or each turn up portion outward end , the pair of chippers including a first chipper and a second chipper ; wherein the first chipper is disposed axially inwardly of the respective bead apex and the second chipper is disposed axially outwardly of the first chipper and axially inwardly of the respective bead apex ; wherein an inboard surface of the second chipper is bonded to an outboard surface of the first chipper ; wherein a radially inward end of the first chipper is disposed radially outwardly of the bead core and the first chipper extends past the turn up portion radially outward end ; and wherein a radially inward end of the second chipper is disposed radially outwardly of the bead core and the second chipper extends past the turn up portion radially outward end ; characterized in that the radially inward end of the second chipper is disposed radially outwardly of the radially inward end of the first chipper by a radial distance of at least 5 millimeters.
A dental matrix for use in repairing and restoring cavities with light-cured restorative material, the dental matrix comprising : (a) a metal substrate comprising a plurality of micro-apertures, wherein the micro- apertures are filled with a transparent or semitransparent resin, and (b) a polymer layer covering the metal substrate and the resin filled micro-apertures for contacting the tooth in use, wherein the transparent or semi-transparent resin used to fill the micro-apertures is not used to form the polymer layer covering the metal substrate, characterized in that the polymer layer is a fluorocarbon. (a) a metal substrate comprising a plurality of micro-apertures, wherein the micro- apertures are filled with a transparent or semitransparent resin, and (b) a polymer layer covering the metal substrate and the resin filled micro-apertures for contacting the tooth in use, wherein the transparent or semi-transparent resin used to fill the micro-apertures is not used to form the polymer layer covering the metal substrate,
Film for arranging and increasing the friction between two frictionally joined components , in particular of a motor vehicle, having a load-bearing matrix and a plurality of hard particles arranged in the matrix , wherein at least one side of the film has a self-adhesive layer for adhesive bonding onto one of the two components and wherein the hard particles at least partially protrude from both surfaces of the matrix, characterized in that the matrix comprises a nonwoven, paper, entangled fibers and/or a porous structure or in that the matrix consists of a nonwoven, of paper, of entangled fibers or of a porous structure.
An irradiation device comprising: a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween; and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber , characterized in that : the at least one light source comprising: a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber , and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide , the light guide having a back surface opposite the front planar surface , the back surface with a plurality of reflectors that depend into the light guide in the direction of the front surface , the plurality of reflectors configured to direct at least part of the light traveling along the light guide out of the light guide through the front surface . a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween; and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber , characterized in that : the at least one light source comprising: a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber , and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide , the light guide having a back surface opposite the front planar surface , the back surface with a plurality of reflectors that depend into the light guide in the direction of the front surface , the plurality of reflectors configured to direct at least part of the light traveling along the light guide out of the light guide through the front surface . a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber , and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide , the light guide having a back surface opposite the front planar surface , the back surface with a plurality of reflectors that depend into the light guide in the direction of the front surface , the plurality of reflectors configured to direct at least part of the light traveling along the light guide out of the light guide through the front surface .
A variable transmission electrophoretic medium comprising a plurality of electrically charged particles, a charge control agent, and a fluid, the charged particles being movable by application of an electric field, wherein the charge control agent comprises an oligoamine-terminated polyolefin and characterized in that the charge control agent further comprises a branched chain fatty acid, wherein the branched chain fatty acid is a 2-alkyl fatty acid comprising at least 12 carbon atoms.
A system comprising: a linear array of lighting nodes connected at different respective positions along a flexible, rigid or malleable continuous supporting line , each of the lighting nodes comprising one or more lighting elements for emitting illumination; the system being characterised in that it further comprises: one or more attachable dividers attached onto said line without severing the line, or at least without completely severing the line, each between a respective pair of the lighting nodes, by means of a mechanical attachment; and a controller arranged to control the illumination emitted by each of the lighting nodes; wherein each of the attachable dividers is configured so as, when attached onto the line, to enable detection of a position at which the divider is attached along the line relative to the lighting nodes, and configured to provide information related to said position to the controller, and thereby divide the lighting nodes into different segments along the line; and wherein the controller is configured to apply a different lighting effect to the illumination emitted by the lighting nodes in each of some or all of the different segments. a linear array of lighting nodes connected at different respective positions along a flexible, rigid or malleable continuous supporting line , each of the lighting nodes comprising one or more lighting elements for emitting illumination; the system being characterised in that it further comprises: one or more attachable dividers attached onto said line without severing the line, or at least without completely severing the line, each between a respective pair of the lighting nodes, by means of a mechanical attachment; and a controller arranged to control the illumination emitted by each of the lighting nodes; wherein each of the attachable dividers is configured so as, when attached onto the line, to enable detection of a position at which the divider is attached along the line relative to the lighting nodes, and configured to provide information related to said position to the controller, and thereby divide the lighting nodes into different segments along the line; and wherein the controller is configured to apply a different lighting effect to the illumination emitted by the lighting nodes in each of some or all of the different segments.
Diffusion stage of a radial or mixed gas turbine engine compressor comprising an impeller formed by two plates , between which the fluid flows in a centrifugal or inclined manner from the centre towards the periphery, blades of a cascade being distributed around said impeller between said plates so as to channel the flow of the fluid between the leading edges of said blades at the centre and the trailing edges at the periphery, at least one of said plates has an internal face comprising at least one zone (Z1, Z2) with alternating hollow and bump curvatures between two adjacent blades in the direction of flow along said blades , and wherein at least one of said plates has an internal face further comprising at least one zone (Z1, Z2) with alternating hollow and bump curvatures between two adjacent blades in an inter-blade tangential direction substantially perpendicular to the direction of flow (F) along said blades, characterized in that it has hollow and bump zones (Z1, Z2) at said leading edge of said blades , starting upstream of said leading edge .
A force sensor comprising: - a sensing system comprising a target piece and a sensing element wherein the sensing element is configured to sense changes of the magnetic field from motion of the target piece with respect to the sensing element , the sensing element being configured to provide a signal representative of the position of the target piece , - an integrated circuit (IC) comprising processing means for processing signals from the sensing element , - characterized in further comprising a semiconductor package comprising the integrated circuit (IC) wherein the package at least partially overmolds the integrated circuit, wherein an external surface of the semiconductor package with a largest area forms an outline, - a flexible piece comprising the target piece , the flexible piece being provided on the external surface of the semiconductor package and attached to the semiconductor package , wherein the flexible piece comprises an attachment area being smaller than or equal to the outline of the external surface of the semiconductor package , the flexible piece being arranged for receiving a force stimulus, so that upon exerting the force on the flexible piece , the displacement of the target piece with respect to the sensing element can be sensed by the sensing element . - a sensing system comprising a target piece and a sensing element wherein the sensing element is configured to sense changes of the magnetic field from motion of the target piece with respect to the sensing element , the sensing element being configured to provide a signal representative of the position of the target piece , - an integrated circuit (IC) comprising processing means for processing signals from the sensing element , - characterized in further comprising a semiconductor package comprising the integrated circuit (IC) wherein the package at least partially overmolds the integrated circuit, wherein an external surface of the semiconductor package with a largest area forms an outline, - a flexible piece comprising the target piece , the flexible piece being provided on the external surface of the semiconductor package and attached to the semiconductor package , wherein the flexible piece comprises an attachment area being smaller than or equal to the outline of the external surface of the semiconductor package , the flexible piece being arranged for receiving a force stimulus, so that upon exerting the force on the flexible piece , the displacement of the target piece with respect to the sensing element can be sensed by the sensing element .
A pneumatic tire, comprising a base tread formed from a rubber composition for tires, the rubber composition comprising: a rubber component including an aromatic vinyl-conjugated diene copolymer that comprises aromatic vinyl units derived from an aromatic vinyl compound and conjugated diene units derived from a conjugated diene compound; carbon black; and silica, the copolymer comprising at least 80% of isolated aromatic vinyl units based on the total aromatic vinyl units as determined according to the method described in paragraph of the description, the copolymer having a glass transition temperature width of more than 10°C but less than 20°C as determined by differential scanning calorimetry according to the method described in paragraph of the description, the rubber component including, based on 100% by mass thereof, 10% by mass or more of the copolymer, the rubber composition comprising 10 parts by mass or more of the silica per 100 parts by mass of the rubber component. a rubber component including an aromatic vinyl-conjugated diene copolymer that comprises aromatic vinyl units derived from an aromatic vinyl compound and conjugated diene units derived from a conjugated diene compound; carbon black; and silica, the copolymer comprising at least 80% of isolated aromatic vinyl units based on the total aromatic vinyl units as determined according to the method described in paragraph of the description, the copolymer having a glass transition temperature width of more than 10°C but less than 20°C as determined by differential scanning calorimetry according to the method described in paragraph of the description, the rubber component including, based on 100% by mass thereof, 10% by mass or more of the copolymer, the rubber composition comprising 10 parts by mass or more of the silica per 100 parts by mass of the rubber component.
A method for identifying mobile device locations and providing location-based services, the method comprising: transmitting a beacon including identifying information identifying a printer , from each of a plurality of printers ; detecting the beacons from each of the plurality of printers , with a mobile device ; determining, at the mobile device , a received signal strength of each beacon; determining, at the mobile device , a printer of the plurality of printers closest to the mobile device based on the received signal strength; sending the identifying information included in the detected beacon of the printer closest to the mobile device from the mobile device to a cloud service ; receiving location aware information from the cloud service into the mobile device , wherein the cloud service determines a location of the mobile device as within a beacon-detection vicinity of the printer associated with the identifying information; sending an instruction from the mobile device to the printer closest to the mobile device via wireless network coupling to print a receipt or coupon; and printing a receipt or a coupon at the printer of the plurality of printers closest to the mobile device . transmitting a beacon including identifying information identifying a printer , from each of a plurality of printers ; detecting the beacons from each of the plurality of printers , with a mobile device ; determining, at the mobile device , a received signal strength of each beacon; determining, at the mobile device , a printer of the plurality of printers closest to the mobile device based on the received signal strength; sending the identifying information included in the detected beacon of the printer closest to the mobile device from the mobile device to a cloud service ; receiving location aware information from the cloud service into the mobile device , wherein the cloud service determines a location of the mobile device as within a beacon-detection vicinity of the printer associated with the identifying information; sending an instruction from the mobile device to the printer closest to the mobile device via wireless network coupling to print a receipt or coupon; and printing a receipt or a coupon at the printer of the plurality of printers closest to the mobile device .
A drive chain system for a spiral conveyor belt , the drive chain system having inner and outer drive chains driving the spiral conveyor belt, the inner and outer drive chains each having a plurality of links defined by a plurality of first and second pitches connected by linking pins extending through holes in the pitches; characterized by at least a portion of the linking pins of at least one of the inner and outer drive chains are hardened, wherein the hardened linking pins are made from austenitic stainless steel having outer surfaces which have been hardened by carbon or nitrogen type atoms introduced into the austenitic stainless steel over a predetermined depth, or wherein the hardened linking pins are made from PH martensitic stainless steel.
A computer-implemented method comprising receiving, by one or more computing devices , a plurality of media items from a communication system, the plurality of media items including at least audio media items corresponding to respective audio transmissions by one or more users associated with a channel of the communication system and visual media items; providing, by a communication process executed by the one or more computing devices, a user interface including an audio track display comprising a time-wise sequence display of the audio media items including individual audio segments arranged based upon a time each audio segment was created, and a visual track display comprising a time-wise sequence display of the visual media items including individual visual media items arranged based upon a time each visual media item was created; a user traversing the audio track display to access, by the one or more computing devices, audio segments that occurred later in time and/or earlier in time with respect to one or more currently displayed audio segments, wherein in response the communication process sequences the display of the visual media items based on the display of the audio segments to display a visual media item having a creation time at least generally corresponding to a creation time of the accessed audio segment; and the user traversing the visual track display to access, by the one or more computing devices, visual media items that occurred later in time and/or earlier in time with respect to one or more currently displayed visual media items, wherein in response the communication process sequences the display of the visual media items independently of the display of audio segments without correspondingly sequencing the display of audio segments within the user interface.