mhurhangee/patent-ind-claim-en huggingface dataset:
An apparatus for administering a single dose of an ophthalmic solution, the apparatus comprising: a vial that includes: a housing , multiple fluid containers disposed within the housing, wherein each fluid container of the multiple fluid containers contains a different ophthalmic solution, and wherein the multiple fluid containers are comprised of materials having different tensile strengths, which enables the different ophthalmic solutions contained in the multiple fluid containers to be sequentially administered in response to multiple applications of varying pressures; and a microfluidic flow channel through which ophthalmic solution is guided when a pressure is applied to the housing that causes deformation of at least one fluid container ; and an applicator tip from which ophthalmic solution is ejected in the form of one or more droplets. a vial that includes: a housing , multiple fluid containers disposed within the housing, wherein each fluid container of the multiple fluid containers contains a different ophthalmic solution, and wherein the multiple fluid containers are comprised of materials having different tensile strengths, which enables the different ophthalmic solutions contained in the multiple fluid containers to be sequentially administered in response to multiple applications of varying pressures; and a microfluidic flow channel through which ophthalmic solution is guided when a pressure is applied to the housing that causes deformation of at least one fluid container ; and a housing , multiple fluid containers disposed within the housing, wherein each fluid container of the multiple fluid containers contains a different ophthalmic solution, and wherein the multiple fluid containers are comprised of materials having different tensile strengths, which enables the different ophthalmic solutions contained in the multiple fluid containers to be sequentially administered in response to multiple applications of varying pressures; and wherein each fluid container of the multiple fluid containers contains a different ophthalmic solution, and wherein the multiple fluid containers are comprised of materials having different tensile strengths, which enables the different ophthalmic solutions contained in the multiple fluid containers to be sequentially administered in response to multiple applications of varying pressures; and a microfluidic flow channel through which ophthalmic solution is guided when a pressure is applied to the housing that causes deformation of at least one fluid container ; and an applicator tip from which ophthalmic solution is ejected in the form of one or more droplets.
A journal foil bearing system comprising: a journal bearing member with a bore and an internal groove within the bore; a shaft received within the bore and supported for rotation relative to the journal bearing member about an axis , the internal groove extending substantially along the axis; at least one biasing foil that is received radially between the journal bearing member and the shaft and that extends circumferentially about the axis; a top foil member with at least one arch-bound top foil received radially between the at least one biasing foil and the shaft, the top foil member including a top foil first end and a top foil second end , wherein the top foil first end and the top foil second end project radially; and characterised in that the top foil first end and the top foil second end are received within the groove of the journal bearing member ; and a foil support insert member is received within the groove, the foil support insert member including a spacer member that extends radially and is disposed between the top foil first end and the top foil second end, the spacer member maintaining the top foil first end and the top foil second end separated, at least, at a distance. a journal bearing member with a bore and an internal groove within the bore; a shaft received within the bore and supported for rotation relative to the journal bearing member about an axis , the internal groove extending substantially along the axis; at least one biasing foil that is received radially between the journal bearing member and the shaft and that extends circumferentially about the axis; a top foil member with at least one arch-bound top foil received radially between the at least one biasing foil and the shaft, the top foil member including a top foil first end and a top foil second end , wherein the top foil first end and the top foil second end project radially; and characterised in that the top foil first end and the top foil second end are received within the groove of the journal bearing member ; and a foil support insert member is received within the groove, the foil support insert member including a spacer member that extends radially and is disposed between the top foil first end and the top foil second end, the spacer member maintaining the top foil first end and the top foil second end separated, at least, at a distance.
A centrifugal pendulum device for application in a drive train of a vehicle powered by an internal combustion engine, consisting of at least one support flange rotating about a rotational axis , with which pendulum masses are associated via a bifilar pendulum suspension in the circumferential direction, which, in the event of a rotational irregularity occurring in the drive train under the influence of centrifugal force in conjunction with cylindrical rollers which are guided in mutually opposing roller tracks of the support flange and of the pendulum masses , execute a movement relative to the support flange and thereby dampen vibrations, wherein the support flange encloses open roller tracks in the direction of the rotational axis and all cylindrical rollers are subjected to a force radially in the direction of the roller tracks by a pre-stressing element , characterised in that a closed or slotted, one-piece or multi-piece, radially pre-stressed spring ring is provided as the pre-stressing element , which is in direct contact with the cylindrical rollers .
A propulsion system for an aquatic vessel , wherein the propulsion system includes at least one Magnus-type rotor including a cylindrical body , which Magnus-type rotor is operable to rotate about a corresponding substantially upright axis, a drive arrangement for rotating the at least one Magnus-type rotor, and a control arrangement for controlling the drive arrangement for varying rates of rotation and/or direction of the at least one Magnus-type rotor, characterized in that the at least one Magnus-type rotor includes a hollow region therein, and is rotationally supported onto a support arrangement which extends into the hollow region, and at least one motor of the drive arrangement for rotating the at least one Magnus-type rotor is included in the hollow region and lies outside the support arrangement, and the at least one motor is accessible for maintenance, and the at least one Magnus-type rotor includes a ventilation aperture arrangement in the upper region of the rotor for enabling an upward movement of air into and out of the cylindrical body to occur in operation within the at least one Magnus-type rotor for ventilating and cooling the drive arrangement and/or other internal components.
A passive intermodulation, i.e. PIM, test system comprising: a PIM antenna configured to be tuned by loop size to receive radio frequency signals comprising the PIM frequency of interest generated by one or more broadcast frequencies of a site antenna, wherein the PIM antenna is a loop antenna; a wand configured to support the PIM antenna on one end and configured for positioning the PIM antenna by hand; a coaxial cable configured to be electrically connected to and extending from the PIM antenna ; a filter configured to be connectable to the coaxial cable and to suppress the broadcast frequencies and pass the PIM frequencies of interest; and a signal analyzer configured to be connectable to the coaxial cable and to display a representation of the PIM received by the PIM antenna; wherein the PIM antenna comprises a near field magnetic field antenna operative to detect a signal from a source of PIM interference broadcast by the site antenna, the source of PIM interference being characterized by a wavelength, by placing the PIM antenna within one wavelength of the source of the PIM interference, and wherein the signal analyzer is configured to locate the source of PIM interference based on the strength of the detected signal. a PIM antenna configured to be tuned by loop size to receive radio frequency signals comprising the PIM frequency of interest generated by one or more broadcast frequencies of a site antenna, wherein the PIM antenna is a loop antenna; a wand configured to support the PIM antenna on one end and configured for positioning the PIM antenna by hand; a coaxial cable configured to be electrically connected to and extending from the PIM antenna ; a filter configured to be connectable to the coaxial cable and to suppress the broadcast frequencies and pass the PIM frequencies of interest; and a signal analyzer configured to be connectable to the coaxial cable and to display a representation of the PIM received by the PIM antenna; wherein the PIM antenna comprises a near field magnetic field antenna operative to detect a signal from a source of PIM interference broadcast by the site antenna, the source of PIM interference being characterized by a wavelength, by placing the PIM antenna within one wavelength of the source of the PIM interference, and wherein the signal analyzer is configured to locate the source of PIM interference based on the strength of the detected signal.
Counter-die cylinder blanket of die cutting machine comprising: - a band of soft plastic material designed to completely surround the counter-die cylinder , provided with a key housed, and - an insert of stiffening material housed in the key , comprising a body of essentially prismatic configuration, provided with a front end , a rear end , a top face , a bottom face and side faces , characterized in that the insert additionally comprises separating protuberances which extend from the bottom face and/or the top face of the body of the insert . - a band of soft plastic material designed to completely surround the counter-die cylinder , provided with a key housed, and - an insert of stiffening material housed in the key , comprising a body of essentially prismatic configuration, provided with a front end , a rear end , a top face , a bottom face and side faces ,
A compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof: wherein, independently for each occurrence: X is -N(R 2 )-; R 2 is hydrogen or a substituted or unsubstituted group selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, (heterocyclyl)alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, amino, amido, aminoalkyl, and alkoxyl; R 5 is selected from the group consisting of hydrogen, alkyl, and haloalkyl; and R 1 is a substituted or unsubstituted group selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, (heterocyclyl)alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, amino, amido, aminoalkyl, and alkoxyl; or R 1 and R 2 , together with the nitrogen to which they are attached, may form a substituted or unsubstituted 3- to 10-membered heterocyclic ring, wherein said ring is monocyclic, bicyclic, tricyclic, or spirocyclic. X is -N(R 2 )-; R 2 is hydrogen or a substituted or unsubstituted group selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, (heterocyclyl)alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, amino, amido, aminoalkyl, and alkoxyl; R 5 is selected from the group consisting of hydrogen, alkyl, and haloalkyl; and R 1 is a substituted or unsubstituted group selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, (heterocyclyl)alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, amino, amido, aminoalkyl, and alkoxyl; or R 1 and R 2 , together with the nitrogen to which they are attached, may form a substituted or unsubstituted 3- to 10-membered heterocyclic ring, wherein said ring is monocyclic, bicyclic, tricyclic, or spirocyclic.
A method for preparing genomic DNA (gDNA) samples for the detection of a single nucleotide polymorphism, the method comprising: (A) providing a sample of buccal epithelial cells from a subject, the buccal epithelial cells adhered to a substrate; (B) agitating, for no more than about 45 seconds, the substrate with the adhered epithelial cells in a first lysis solution capable of lysing buccal cells adhered to the substrate; (C) removing the substrate from the first lysis solution upon completion of the agitating (B) the substrate in the first lysis solution; (D) extracting gDNA from the first lysis solution after removing (C) the substrate from the first lysis solution to prepare a first gDNA sample; (E) agitating the substrate, after removing (C) the substrate from the first lysis solution, in a second lysis solution capable of lysing buccal cells adhered to the substrate; (F) removing the substrate from the second lysis solution; and (G) extracting second gDNA from the second lysis solution after removing (F) the substrate from the second lysis solution to prepare a second gDNA sample. (A) providing a sample of buccal epithelial cells from a subject, the buccal epithelial cells adhered to a substrate; (B) agitating, for no more than about 45 seconds, the substrate with the adhered epithelial cells in a first lysis solution capable of lysing buccal cells adhered to the substrate; (C) removing the substrate from the first lysis solution upon completion of the agitating (B) the substrate in the first lysis solution; (D) extracting gDNA from the first lysis solution after removing (C) the substrate from the first lysis solution to prepare a first gDNA sample; (E) agitating the substrate, after removing (C) the substrate from the first lysis solution, in a second lysis solution capable of lysing buccal cells adhered to the substrate; (F) removing the substrate from the second lysis solution; and (G) extracting second gDNA from the second lysis solution after removing (F) the substrate from the second lysis solution to prepare a second gDNA sample.
A biocompatible nanoparticle composition comprising a plurality of long circulating nanoparticles, each comprising: poly(lactic)acid-poly(ethylene)glycol block copolymer, wherein the poly(lactic)acid has a number average weight of about 16 kDa and the poly(ethylene)glycol has a number average molecular weight of about 5 kDa; a therapeutic agent selected from the group consisting of vincristine, vinblastine, methotrexate, paclitaxel and sirolimus; and a biocompatible polymer coupled to a targeting moiety; wherein the long circulating nanoparticles comparise about 80 to about 90 weight percent poly(lactic)acid-poly(ethylene)glycol block copolymer and about 1 to about 4% by weight of the biocompatible polymer coupled to a targeting moiety; said composition providing an elevated plasma concentration of the therapeutic agent for at least 12 hours when the composition is administered to a patient. poly(lactic)acid-poly(ethylene)glycol block copolymer, wherein the poly(lactic)acid has a number average weight of about 16 kDa and the poly(ethylene)glycol has a number average molecular weight of about 5 kDa; a therapeutic agent selected from the group consisting of vincristine, vinblastine, methotrexate, paclitaxel and sirolimus; and a biocompatible polymer coupled to a targeting moiety; wherein the long circulating nanoparticles comparise about 80 to about 90 weight percent poly(lactic)acid-poly(ethylene)glycol block copolymer and about 1 to about 4% by weight of the biocompatible polymer coupled to a targeting moiety; said composition providing an elevated plasma concentration of the therapeutic agent for at least 12 hours when the composition is administered to a patient.
Method for manufacturing microfluidic chips having at least one capillary for through-flow of a fluid, characterized by the steps of: (a) providing a starting material; (b) forming at least one shared capillary in the starting material, said shared capillary comprising an fluidic inlet and an fluidic outlet ; (c) functionalizing the chips by supplying a functionalization fluid to the shared capillary; and (d) dividing the starting material into separate chips . (a) providing a starting material; (b) forming at least one shared capillary in the starting material, said shared capillary comprising an fluidic inlet and an fluidic outlet ; (c) functionalizing the chips by supplying a functionalization fluid to the shared capillary; and (d) dividing the starting material into separate chips .
A clamp spring for spreading the load from a clamp (1;101;201;301;401;501) mounted around a tubular member, the spring comprising a resilient body (6;106;206;306;406;506) having first and second ends (8;108,208;308;408;508), an internal surface (7;107;207;307;407;507) adapted to seat within a clamp member and an outer surface (9;109;209;309;409;509) adapted to contact the outer surface of the tubular member, the internal and outer surfaces of the resilient body of the spring extending between the first and second ends of the resilient body of the spring and wherein a stiffness of the resilient body of the spring varies over a length of the resilient body of the spring between the first and second ends of the resilient body of the spring, the stiffness being higher towards the first and second ends of the resilient body of the spring than in a centre of the resilient body of the spring.
A method of generating a radiation treatment plan for radiation treatment, the method comprising: dividing at least one dose characteristic related to a dose distribution for a Region Of Interest, ROI, of a subject into a plurality of subintervals, wherein each subinterval has values of the at least one dose characteristic that differ from values of the at least one dose characteristic of other subintervals and wherein said ROI of the subject is divided into a plurality of voxels; partitioning the plurality of voxels into a plurality of different partitions based on the plurality of subintervals of the at least one dose characteristics, wherein all voxels with values of the at least one dose characteristic that fall within the same subinterval are partitioned into the same partition; for each of the plurality of different partitions, establishing a weight, wherein the weight reflects the relative importance of a dose criterion of the partition of the ROI of the subject; for each of the plurality of different partitions, specifying an optimization function for an obtainable dose distribution based on the respective subinterval of dose characteristics, wherein respective optimization function determines how the obtainable dose distribution is obtained in each partition; and generating the radiation treatment plan based on said established weights and said specified optimization functions for dose distribution for the respective partitions. dividing at least one dose characteristic related to a dose distribution for a Region Of Interest, ROI, of a subject into a plurality of subintervals, wherein each subinterval has values of the at least one dose characteristic that differ from values of the at least one dose characteristic of other subintervals and wherein said ROI of the subject is divided into a plurality of voxels; partitioning the plurality of voxels into a plurality of different partitions based on the plurality of subintervals of the at least one dose characteristics, wherein all voxels with values of the at least one dose characteristic that fall within the same subinterval are partitioned into the same partition; for each of the plurality of different partitions, establishing a weight, wherein the weight reflects the relative importance of a dose criterion of the partition of the ROI of the subject; for each of the plurality of different partitions, specifying an optimization function for an obtainable dose distribution based on the respective subinterval of dose characteristics, wherein respective optimization function determines how the obtainable dose distribution is obtained in each partition; and generating the radiation treatment plan based on said established weights and said specified optimization functions for dose distribution for the respective partitions.
A method for identity verification, the method comprising: detecting, by a control program, a target service program that runs a target process, wherein the target process is used to process a service interface, wherein detecting comprises detecting a call interface of a target function to learn that the target service program is running the target process; suspending the target service program when it is detected that the target service program is running the target process; and calling an identity verification program to perform identity verification, to obtain an identity verification result, wherein the identity verification program and the target service program are independent of each other. detecting, by a control program, a target service program that runs a target process, wherein the target process is used to process a service interface, wherein detecting comprises detecting a call interface of a target function to learn that the target service program is running the target process; suspending the target service program when it is detected that the target service program is running the target process; and calling an identity verification program to perform identity verification, to obtain an identity verification result, wherein the identity verification program and the target service program are independent of each other.
Drive device for an impeller of a fluid flow machine , having an electric motor and a frequency converter connected to an alternating current mains network , wherein the electric motor is controllable via the frequency converter , characterized in that the drive device comprises a reduction gear , in that the electric motor is formed as a brushless, permanently excited synchronous motor with permanent magnets arranged inside the rotor, and in that the frequency converter is configured to control the synchronous motor with a frequency exceeding the mains frequency, and in that the reduction gear is connected between the synchronous motor and the impeller so that the synchronous motor drives the impeller with the interposition of the reduction gear .