mhurhangee/patent-ind-claim-en huggingface dataset:
An apparatus comprising: a firmware memory configured to store firmware; a cache memory configured to load from the firmware memory at least part of the firmware for execution by a processor ; and a firmware checking engine configured to access the cache memory and the firmware memory, the firmware checking engine having a defined syndrome storage location storing a known initial value, the firmware checking engine being further configured to perform the following operations iteratively on a plurality of cache line entries associated with said at least part of the firmware stored in the cache memory: A) choose a cache line entry from said plurality of cache line entries; B) verify that an address mapped in the cache line entry maps to an address in the firmware memory, and producing a firmware mapping result; and C) when said cache line entry is locked and said firmware mapping result indicates that an address mapped in the cache line entry maps to an address in the firmware memory, compare a content of said cache line entry to a content of a corresponding address in the firmware stored in the firmware memory, and produce an integrity result indicating whether integrity of the apparatus has been compromised. a firmware memory configured to store firmware; a cache memory configured to load from the firmware memory at least part of the firmware for execution by a processor ; and a firmware checking engine configured to access the cache memory and the firmware memory, the firmware checking engine having a defined syndrome storage location storing a known initial value, the firmware checking engine being further configured to perform the following operations iteratively on a plurality of cache line entries associated with said at least part of the firmware stored in the cache memory: A) choose a cache line entry from said plurality of cache line entries; B) verify that an address mapped in the cache line entry maps to an address in the firmware memory, and producing a firmware mapping result; and C) when said cache line entry is locked and said firmware mapping result indicates that an address mapped in the cache line entry maps to an address in the firmware memory, compare a content of said cache line entry to a content of a corresponding address in the firmware stored in the firmware memory, and produce an integrity result indicating whether integrity of the apparatus has been compromised. A) choose a cache line entry from said plurality of cache line entries; B) verify that an address mapped in the cache line entry maps to an address in the firmware memory, and producing a firmware mapping result; and C) when said cache line entry is locked and said firmware mapping result indicates that an address mapped in the cache line entry maps to an address in the firmware memory, compare a content of said cache line entry to a content of a corresponding address in the firmware stored in the firmware memory, and produce an integrity result indicating whether integrity of the apparatus has been compromised.
A bioconjugation method comprising the step of conjugating an antibody molecule containing a first unsaturated functional group with a drug comprising a second unsaturated functional group, wherein the first and second unsaturated functional groups are complementary to each other such that conjugation is a reaction of said functional groups via a Diels-Alder reaction which forms a cyclohexene ring, wherein the first functional group is a diene and the second functional group is a maleimide.
A humanized anti-CCR7 antibody comprising the hypervariable regions HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 and HVR-L3, wherein: HVR-H1 comprises SEQ ID NO: 6; HVR-H2 H1 comprises SEQ ID NO: 13; HVR-H3 H1 comprises SEQ ID NO: 19; HVR-L1 H1 comprises SEQ ID NO: 27; HVR-L2 H1 comprises SEQ ID NO: 31; and HVR-L3 H1 comprises SEQ ID NO: 36, and wherein antibody has at least one of: a) a minimal affinity for a synthetic antigen with the amino acid sequence of SEQ ID NO: 76, defined by a K d that is not more than a factor 10 higher than the K d of a mouse anti-CCR7 antibody of which the amino acid sequence of the heavy chain variable domain is SEQ ID NO: 1 and of which the amino acid sequence of the light chain variable domain is SEQ ID NO: 2; and, b) an IC 50 of no more than 100 nM for inhibiting at least one of CCR7-dependent intracellular signalling and CCR7 receptor internalization, by at least one CCR7-ligand selected from CCL19 and CCL21. HVR-H1 comprises SEQ ID NO: 6; HVR-H2 H1 comprises SEQ ID NO: 13; HVR-H3 H1 comprises SEQ ID NO: 19; HVR-L1 H1 comprises SEQ ID NO: 27; HVR-L2 H1 comprises SEQ ID NO: 31; and HVR-L3 H1 comprises SEQ ID NO: 36, a) a minimal affinity for a synthetic antigen with the amino acid sequence of SEQ ID NO: 76, defined by a K d that is not more than a factor 10 higher than the K d of a mouse anti-CCR7 antibody of which the amino acid sequence of the heavy chain variable domain is SEQ ID NO: 1 and of which the amino acid sequence of the light chain variable domain is SEQ ID NO: 2; and, b) an IC 50 of no more than 100 nM for inhibiting at least one of CCR7-dependent intracellular signalling and CCR7 receptor internalization, by at least one CCR7-ligand selected from CCL19 and CCL21.
Watch including at least one horological structure equipped with at least one fastening means , at least one component including at least one through-hole , and at least one device for fastening said component to said structure , said device including at least one fastening element sized such that it can be inserted in said hole with non-zero radial clearance, said fastening element including complementary fastening means arranged to co-operate, in a complementary manner, with a said fastening means of said structure , said device including at least one spacer arranged to be inserted between said component and said fastening element and to keep them at an axial and radial distance from each other, and to withstand an axial force resulting from the cooperation between said fastening means and said complementary fastening means when said fastening element is in its position closest to said structure , said component being a sapphire or mother-of-pearl watch dial.
A surface extraction method performed by a processor comprising: a first step of investigating, in a three-dimensional space that is divided into voxels having a lattice shape, in units of voxel rows of the voxels, whether or not constituting voxels that constitute a three-dimensional image of a finger or blood vessels in a finger which is shown in the three-dimensional space exist; a second step of extracting, as surfaces of the three-dimensional image of a finger or blood vessels in a finger, the constituting regions that exist at ends of voxel rows, such that the finger constituting voxels or the blood vessel constituting voxels that exist in the middle of the voxel rows are ignored and only the voxels at the ends of the voxel rows are extracted. a first step of investigating, in a three-dimensional space that is divided into voxels having a lattice shape, in units of voxel rows of the voxels, whether or not constituting voxels that constitute a three-dimensional image of a finger or blood vessels in a finger which is shown in the three-dimensional space exist; a second step of extracting, as surfaces of the three-dimensional image of a finger or blood vessels in a finger, the constituting regions that exist at ends of voxel rows, such that the finger constituting voxels or the blood vessel constituting voxels that exist in the middle of the voxel rows are ignored and only the voxels at the ends of the voxel rows are extracted.
Method for producing a dental prosthesis based on lithium silicate glass or lithium silicate glass-ceramic, comprising the method steps: - melting a powder with the composition in wt-% SiO 2 50 - 70 % Li 2 O 5 - 25 % Al 2 O 3 0.1 - 20 % K 2 O 0.1 - 15 % CeO 2 0.1 - 15 % B 2 O 3 0 - 5 % P 2 O 5 0 - 15 % Tb 2 O 3 0 - 2 % ZrO 2 0 - 15 % ZnO 2 0 - 4 % as well as at least an additive between 0.1 and 5 wt-% of an oxide from the group BaO, CaO, MgO, MnO, Er 2 O 3 , Gd 2 O 3 , Na 2 O, Pr 2 O 3 , Pr 6 O 11 , Sm 2 O 3 , TiO 2 , V 2 O 5 , Y 2 O 3 , - producing spherical, lens-shaped or rod-shaped glass particles solidified from the melt; - portioning the glass particles and filling them into a crucible; - melting the glass particles in the crucible and setting a viscosity ν, wherein 4 dPa·s ≤ ν ≤ 80 dPa·s; - casting the thus produced melt into a negative mold which is enclosed by an investment material and corresponds to the dental prosthesis; - solidifying the melt in the negative mold, - crystallizing lithium metasilicate as main crystalline phase from the solidified melt by employing a first heat treatment at a temperature between 600 °C and 760 °C over a time between 20 min and 120 min, - crystallizing lithium disilicate as main crystalline phase during a second heat treatment at a temperature between 760 °C and 860 °C over a time between 5 min and 60 min, - wherein the first and second heat treatment takes place within the investment material or after removal of the solidified melt from the investment material. - melting a powder with the composition in wt-% SiO 2 50 - 70 % Li 2 O 5 - 25 % Al 2 O 3 0.1 - 20 % K 2 O 0.1 - 15 % CeO 2 0.1 - 15 % B 2 O 3 0 - 5 % P 2 O 5 0 - 15 % Tb 2 O 3 0 - 2 % ZrO 2 0 - 15 % ZnO 2 0 - 4 % as well as at least an additive between 0.1 and 5 wt-% of an oxide from the group BaO, CaO, MgO, MnO, Er 2 O 3 , Gd 2 O 3 , Na 2 O, Pr 2 O 3 , Pr 6 O 11 , Sm 2 O 3 , TiO 2 , V 2 O 5 , Y 2 O 3 , - producing spherical, lens-shaped or rod-shaped glass particles solidified from the melt; - portioning the glass particles and filling them into a crucible; - melting the glass particles in the crucible and setting a viscosity ν, wherein 4 dPa·s ≤ ν ≤ 80 dPa·s; - casting the thus produced melt into a negative mold which is enclosed by an investment material and corresponds to the dental prosthesis; - solidifying the melt in the negative mold, - crystallizing lithium metasilicate as main crystalline phase from the solidified melt by employing a first heat treatment at a temperature between 600 °C and 760 °C over a time between 20 min and 120 min, - crystallizing lithium disilicate as main crystalline phase during a second heat treatment at a temperature between 760 °C and 860 °C over a time between 5 min and 60 min, - wherein the first and second heat treatment takes place within the investment material or after removal of the solidified melt from the investment material.
A buffered antibody formulation, comprising: an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO: 1 and a light chain comprising the amino acid sequence of SEQ ID NO: 2, wherein the formulation comprises from 30 mg to 50 mg of the antibody, a buffer comprising from 0.7 mM to 1.3 mM of an acetate salt, from 200 mM to 206 mM of mannitol, from 16 mM to 22 mM of glacial acetic acid, and from 24 mM to 28 mM of sodium chloride, and 0.07% (v/v) to 0.15% (v/v) of polysorbate 80, wherein the antibody formulation has a pH of from 5.1 to 5.3. an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO: 1 and a light chain comprising the amino acid sequence of SEQ ID NO: 2, wherein the formulation comprises from 30 mg to 50 mg of the antibody, a buffer comprising from 0.7 mM to 1.3 mM of an acetate salt, from 200 mM to 206 mM of mannitol, from 16 mM to 22 mM of glacial acetic acid, and from 24 mM to 28 mM of sodium chloride, and 0.07% (v/v) to 0.15% (v/v) of polysorbate 80, wherein the antibody formulation has a pH of from 5.1 to 5.3.
Locking device for a door or a window, comprising a main lock serving for actuation and at least one secondary lock coupled to the main lock by means of a drive rod , the secondary lock having a latch bolt and a pivot bolt , the pivot bolt having, as a pivot bolt drive, a spring acting on the pivot bolt , by means of which spring the pivot bolt is preloaded in a position in which it is pivoted into the secondary lock , the pivot bolt being coupled to the latch bolt in such a way that when the latch bolt reaches a partially extended limit position when extending out of the secondary lock , the pivot bolt , released and driven by the spring , is pivoted into a position in which it is pivoted out of the secondary lock , the pivot bolt being decoupled from the drive rod when it is pivoted out, characterized in that the pivot bolt is coupled to the latch bolt by means of a two-armed release lever , a first arm of the release lever being able to be actuated by the latch bolt and a second arm of the release lever blocking or releasing the pivot bolt .
A method of determining an encoding mode, the method comprising: determining an initial encoding mode of a current frame as a spectrum domain encoding mode from among a plurality of encoding modes when an audio signal is classified as a music signal by using characteristics of the audio signal; correcting the spectrum domain encoding mode to a Generic Signal Coding, GSC, mode for excitation encoding based on correction parameters; and determining a final encoding mode of the current frame from among the spectrum domain encoding mode and the GSC mode based on encoding modes of frames corresponding to a hangover length so as to prevent a frequent switching of the encoding mode. determining an initial encoding mode of a current frame as a spectrum domain encoding mode from among a plurality of encoding modes when an audio signal is classified as a music signal by using characteristics of the audio signal; correcting the spectrum domain encoding mode to a Generic Signal Coding, GSC, mode for excitation encoding based on correction parameters; and determining a final encoding mode of the current frame from among the spectrum domain encoding mode and the GSC mode based on encoding modes of frames corresponding to a hangover length so as to prevent a frequent switching of the encoding mode.
A sheet-fed offset printing press comprising: at least one printing unit each comprising: a sheet conveyance cylinder configured to hold and convey a sheet ; and a printing device configured to print the sheet held by the sheet conveyance cylinder , and a sheet conveyance apparatus comprising: a transfer cylinder configured to hand over the sheet to the sheet conveyance cylinder ; and a pressing cylinder contacting the transfer cylinder and configured to press the sheet held by the transfer cylinder against an outer surface of the transfer cylinder , wherein the pressing cylinder is configured to bring the sheet in tight contact with the outer surface of the transfer cylinder and to stretch the sheet , characterized in that the transfer cylinder is contacting the sheet conveyance cylinder of a printing unit of the at least one printing unit located on the most upstream side in a sheet conveyance direction, and the transfer cylinder has a same diameter as a diameter of the sheet conveyance cylinder . at least one printing unit each comprising: a sheet conveyance cylinder configured to hold and convey a sheet ; and a printing device configured to print the sheet held by the sheet conveyance cylinder , and a sheet conveyance cylinder configured to hold and convey a sheet ; and a printing device configured to print the sheet held by the sheet conveyance cylinder , and a sheet conveyance apparatus comprising: a transfer cylinder configured to hand over the sheet to the sheet conveyance cylinder ; and a pressing cylinder contacting the transfer cylinder and configured to press the sheet held by the transfer cylinder against an outer surface of the transfer cylinder , a transfer cylinder configured to hand over the sheet to the sheet conveyance cylinder ; and a pressing cylinder contacting the transfer cylinder and configured to press the sheet held by the transfer cylinder against an outer surface of the transfer cylinder , wherein the pressing cylinder is configured to bring the sheet in tight contact with the outer surface of the transfer cylinder and to stretch the sheet , characterized in that the transfer cylinder is contacting the sheet conveyance cylinder of a printing unit of the at least one printing unit located on the most upstream side in a sheet conveyance direction, and the transfer cylinder has a same diameter as a diameter of the sheet conveyance cylinder .
A traction control system for a motor vehicle , the traction control system comprising an electronic controller configured to identify a wheelslip condition and initiate a traction control intervention at one or more vehicle wheels in dependence on the wheelslip condition, wherein the electronic controller is configured to modify the traction control intervention in dependence on a reduced wheel load condition in said one or more wheels, the reduced wheel load condition being identified based on at least one of: a signal indicative of vehicle pitch; and a signal indicative of vehicle heave, wherein the controller is configured to modify the traction control intervention by inhibiting the traction control intervention; wherein the signal indicative of vehicle pitch comprises vehicle pitch data and/or the signal indicative of vehicle heave comprises vehicle heave data; and wherein the vehicle pitch data comprise a pitch profile over time associated with the reduced wheel load condition, and/or wherein the heave data comprise a heave profile over time associated with the reduced wheel load condition.
A battery module comprising: an end plate; and side plates ; characterized in that the end plate comprises: a body ; and connecting plates connected to edges of the body , wherein the connecting plates extend along a height direction of the battery module, and the body is fixedly connected to the side plates of the battery module through the connecting plates by laser welding, wherein the body is made of aluminum, the connecting plates are made of steel, and the side plates are made of steel. an end plate; and side plates ; characterized in that the end plate comprises: a body ; and connecting plates connected to edges of the body , wherein the connecting plates extend along a height direction of the battery module, and the body is fixedly connected to the side plates of the battery module through the connecting plates by laser welding, wherein the body is made of aluminum, the connecting plates are made of steel, and the side plates are made of steel. a body ; and connecting plates connected to edges of the body , wherein the connecting plates extend along a height direction of the battery module, and the body is fixedly connected to the side plates of the battery module through the connecting plates by laser welding, wherein the body is made of aluminum, the connecting plates are made of steel, and the side plates are made of steel.
An implantable leadless pacemaker (LP) configured to be implanted in or on a first cardiac chamber of a patient and configured to pace the first cardiac chamber and adjust a pacing rate at which the first cardiac chamber is paced based on a pacing rate indicator included in an implant-to-implant (i2i) message received from an implantable medical device (IMD) remotely located relative to the LP , the LP comprising: at least one receiver configured to receive i2i messages; and a controller configured to: determine whether a received i2i message includes a pacing rate indicator that informs the LP of a new pacing rate at which the LP should pace the first cardiac chamber, characterized in that the controller is further configured to: determine whether adjusting the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause an adjustment to the pacing rate to exceed a rate adjustment threshold; and limit the adjustment to the pacing rate to a specified amount, in response to determining that the adjustment to the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause the adjustment to the pacing rate to exceed the rate adjustment threshold. at least one receiver configured to receive i2i messages; and a controller configured to: determine whether a received i2i message includes a pacing rate indicator that informs the LP of a new pacing rate at which the LP should pace the first cardiac chamber, characterized in that the controller is further configured to: determine whether adjusting the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause an adjustment to the pacing rate to exceed a rate adjustment threshold; and limit the adjustment to the pacing rate to a specified amount, in response to determining that the adjustment to the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause the adjustment to the pacing rate to exceed the rate adjustment threshold. determine whether adjusting the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause an adjustment to the pacing rate to exceed a rate adjustment threshold; and limit the adjustment to the pacing rate to a specified amount, in response to determining that the adjustment to the pacing rate of the first cardiac chamber to match the new pacing rate specified by the pacing rate indicator would cause the adjustment to the pacing rate to exceed the rate adjustment threshold.
A system for treating a respiratory disorder in a patient , the system comprising a patient interface , a pressure generator configured to generate, for treating the respiratory disorder, a downstream air flow having a flow rate and a pressure, and an air path in fluid communication with an air outlet of the pressure generator and an air inlet of the patient interface , the system comprising a flow rate sensor for measuring the gas flow rate of the flow of breathable gas being directed to the patient interface , said flow rate sensor comprising: first and second acoustic generators , the first and second acoustic generators separated by a distance along the air path to the patient interface , the first and second acoustic generators configured to sample the flow of breathable gas within the air path ; wherein the first and second acoustic generators are configured to generate acoustic signals that produce a detectable beat frequency representative of the flow rate or the pressure of the air path . first and second acoustic generators , the first and second acoustic generators separated by a distance along the air path to the patient interface , the first and second acoustic generators configured to sample the flow of breathable gas within the air path ; wherein the first and second acoustic generators are configured to generate acoustic signals that produce a detectable beat frequency representative of the flow rate or the pressure of the air path .