A method for detecting an analyte in a sample, comprising: contacting an analyte and optionally a tag-linked analyte, a first recognition component , and a second recognition component linked with an amplification element to generate a complex comprising the first recognition component and the second recognition component linked with the amplification element , wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component , wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component ; and wherein the second recognition component is conjugated to a first binding partner , the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner , and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); contacting the amplification element linked with an amplification precursor under conditions to convert the amplification precursor into a molecule that adds mass at a surface of the TFBAR ; and measuring mass added at the surface of the TFBAR . contacting an analyte and optionally a tag-linked analyte, a first recognition component , and a second recognition component linked with an amplification element to generate a complex comprising the first recognition component and the second recognition component linked with the amplification element , wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component , wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component ; and wherein the second recognition component is conjugated to a first binding partner , the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner , and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); wherein the first recognition component is immobilized on a surface of a thin film bulk acoustic resonator (TFBAR) having a resonance frequency of 1.8 GHz or greater and is configured to selectively bind one or more of the analyte and optionally a tag-linked analyte bound to the second recognition component , wherein the second recognition component linked with the amplification element is configured to selectively bind the analyte and optionally the tag-linked analyte bound to the first recognition component ; and wherein the second recognition component is conjugated to a first binding partner , the amplification element is conjugated to a second binding partner configured to selectively bind to the first binding partner , and wherein the amplification element is linked to the second recognition component via binding between the first and second binding partners (123 and 135); contacting the amplification element linked with an amplification precursor under conditions to convert the amplification precursor into a molecule that adds mass at a surface of the TFBAR ; and measuring mass added at the surface of the TFBAR . <EOS>