mhurhangee/patent-ind-claim-en huggingface dataset:
Radioimmunoconjugate (RIC) for use as a medicament in bone-marrow conditioning, particularly preceding stem cell transplantation, wherein the RIC comprises a CD66-binding component and a therapeutically effective radionuclide, wherein the CD66-binding component is an antibody, wherein the radionuclide is linked to the CD66-binding component via a chelating agent, which is covalently linked to the CD66-binding component and wherein the therapeutic RIC is for administration to a patient who is ineligible to treatment with high dose-melphalan preceding HSCT and/or to a patient who was treated with induction therapy but had disease progression. wherein the CD66-binding component is an antibody, wherein the radionuclide is linked to the CD66-binding component via a chelating agent, which is covalently linked to the CD66-binding component and wherein the therapeutic RIC is for administration to a patient who is ineligible to treatment with high dose-melphalan preceding HSCT and/or to a patient who was treated with induction therapy but had disease progression.
A compound selected from the group consisting of Formula I3 and Formula I4
Fusion protein comprising two IL-17A binding polypeptides with an albumin binding moiety between them; wherein the amino acid sequence of said first and second IL-17A binding polypeptide may be the same or different; wherein each of said first and second IL-17A binding polypeptide comprises an IL-17A binding motif BM, which motif consists of an amino acid sequence selected from i) the sequence from position 8 to position 36 in a sequence selected from the group consisting of SEQ ID NO:1, 11, 1206, and 1218-1222; and ii) an amino acid sequence which has at least 96% identity to an amino acid sequence defined in i); wherein said albumin binding moiety increases the in vivo half-life of the fusion protein; and wherein said albumin binding moiety comprises an albumin binding domain of SEQ ID NO:1224. wherein the amino acid sequence of said first and second IL-17A binding polypeptide may be the same or different; wherein each of said first and second IL-17A binding polypeptide comprises an IL-17A binding motif BM, which motif consists of an amino acid sequence selected from i) the sequence from position 8 to position 36 in a sequence selected from the group consisting of SEQ ID NO:1, 11, 1206, and 1218-1222; and ii) an amino acid sequence which has at least 96% identity to an amino acid sequence defined in i); i) the sequence from position 8 to position 36 in a sequence selected from the group consisting of SEQ ID NO:1, 11, 1206, and 1218-1222; and ii) an amino acid sequence which has at least 96% identity to an amino acid sequence defined in i); wherein said albumin binding moiety increases the in vivo half-life of the fusion protein; and wherein said albumin binding moiety comprises an albumin binding domain of SEQ ID NO:1224.
A method of increasing the heat-resistance or cold-resistance of bacteria of the Lactobacillales order comprising: (a) in vitro co-culturing the bacteria of the Lactobacillales order with biofilm-producing bacteria of the Bacillus genus in a growth substrate under conditions that generate a biofilm which comprises said bacteria of the Lactobacillales order and said biofilm-producing bacteria of the Bacillus genus; and (b) isolating said biofilm from said growth substrate, thereby increasing the heat-resistance or cold-resistance of bacteria of the Lactobacillales order. (a) in vitro co-culturing the bacteria of the Lactobacillales order with biofilm-producing bacteria of the Bacillus genus in a growth substrate under conditions that generate a biofilm which comprises said bacteria of the Lactobacillales order and said biofilm-producing bacteria of the Bacillus genus; and (b) isolating said biofilm from said growth substrate, thereby increasing the heat-resistance or cold-resistance of bacteria of the Lactobacillales order.
A resin that is the reaction product of: one or more polythiols having between two and ten thiol moieties; one or more polyepoxides having between two and ten epoxy moieties; one or more solid particulate fillers; and one or more amine catalysts of the formula NR 1 R 2 R 3 , or a salt thereof, wherein each of R 1 , R 2 , and R 3 is independently linear or branched C1-20 alkyl or two or more of R 1 , R 2 , and R 3 combine, with the N to which they are bonded, to form a cyclic moiety, and wherein the resin preferably has a compressive strength of at least 97 Mpa (14 ksi) at 2% offset at 21°C (70°F) and at least 55 Mpa (8 ksi) at 2% offset at 88°C (190°F), said compressive strength being measured in accordance with ASTM 695. one or more polythiols having between two and ten thiol moieties; one or more polyepoxides having between two and ten epoxy moieties; one or more solid particulate fillers; and one or more amine catalysts of the formula NR 1 R 2 R 3 , or a salt thereof, wherein each of R 1 , R 2 , and R 3 is independently linear or branched C1-20 alkyl or two or more of R 1 , R 2 , and R 3 combine, with the N to which they are bonded, to form a cyclic moiety, and wherein the resin preferably has a compressive strength of at least 97 Mpa (14 ksi) at 2% offset at 21°C (70°F) and at least 55 Mpa (8 ksi) at 2% offset at 88°C (190°F), said compressive strength being measured in accordance with ASTM 695.
A first optical device for use in endoscope procedures and operable to image in a first mode with white light and a second mode with fluoresced light outside the visible band and comprising: an image sensor assembly including one or more image sensors operable for capturing white light images and fluoresced light images; and a focus adjustment mechanism , wherein the mechanism is positioned in the first optical device and configured to automatically adjust the focus of the first optical device in switching between a first mode for white light and a second mode for fluoresced light, and wherein the automatic focus adjustment compensates for a chromatic focal difference between the white light image and the fluoresced light image caused by the dispersive or diffractive properties of optical materials or optical design employed in an assembly construction of the first optical device or an optional second optical device connected to the first optical device , or both, wherein the first optical device is a camera head that attaches to and detaches from the second optical device, and the second optical device is an endoscope , wherein the camera head is configured to automatically recognize the second optical device and, in response, automatically apply a known, prescribed adjustment based on known characteristics of the second optical device. an image sensor assembly including one or more image sensors operable for capturing white light images and fluoresced light images; and a focus adjustment mechanism , wherein the mechanism is positioned in the first optical device and configured to automatically adjust the focus of the first optical device in switching between a first mode for white light and a second mode for fluoresced light, and wherein the automatic focus adjustment compensates for a chromatic focal difference between the white light image and the fluoresced light image caused by the dispersive or diffractive properties of optical materials or optical design employed in an assembly construction of the first optical device or an optional second optical device connected to the first optical device , or both, wherein the first optical device is a camera head that attaches to and detaches from the second optical device, and the second optical device is an endoscope , wherein the camera head is configured to automatically recognize the second optical device and, in response, automatically apply a known, prescribed adjustment based on known characteristics of the second optical device.
A method of forming reinforced packages , the method comprising: forming an attached web (W') by adhering a construct to a web of material ; moving the attached web (W') in a downstream direction (M) through at least a web edge forming assembly and a construct forming assembly , the moving the attached web (W') comprising moving the construct with the web of material ; at least partially forming a folded web by folding at least a portion of the web of material as the attached web (W') moves through the web edge forming assembly ; forming a folded construct by folding at least a portion of the construct to extend at least partially over the folded web as the attached web (W') moves through the construct forming assembly ; and forming a reinforced package comprising a liner and the folded construct by separating the liner from a remainder of the folded web , the folded construct being adhered to the liner . forming an attached web (W') by adhering a construct to a web of material ; moving the attached web (W') in a downstream direction (M) through at least a web edge forming assembly and a construct forming assembly , the moving the attached web (W') comprising moving the construct with the web of material ; at least partially forming a folded web by folding at least a portion of the web of material as the attached web (W') moves through the web edge forming assembly ; forming a folded construct by folding at least a portion of the construct to extend at least partially over the folded web as the attached web (W') moves through the construct forming assembly ; and forming a reinforced package comprising a liner and the folded construct by separating the liner from a remainder of the folded web , the folded construct being adhered to the liner .
Feeding apparatus for feeding bulk material into a screw machine, having - a feed pipe for conducting a bulk material flowing in a delivery direction , - an induction coil for detecting a metal particle in the bulk material , - a removal device for removing the detected metal particle from the bulk material , and - a control device for activating the removal device , characterized in that the removal device has a displaceable screen element by means of an actuating drive of the feeding apparatus having a multiplicity of through-openings for the bulk material . - a feed pipe for conducting a bulk material flowing in a delivery direction , - an induction coil for detecting a metal particle in the bulk material , - a removal device for removing the detected metal particle from the bulk material , and - a control device for activating the removal device ,
Cannula for injecting a fluid (F1) into a cavity of the human or animal body, comprising: - a main lumen (LP) defining a first space of the cannula for the fluid (F1) to flow in a first direction; and - an accessory reperfusion lumen (LA) defining a second space of the cannula and comprising: o an inlet for collecting a portion of the fluid (F1) flowing in the first direction; o an angled portion for changing the direction of flow of the fluid (F1) collected by the accessory reperfusion lumen (LA); and o an outlet for discharging the collected fluid (F1) in a second direction into the cavity , characterized in that the cannula comprises a device for positioning the cannula in the cavity , the positioning device comprising a stop and movement means configured to move said stop along an auxiliary lumen (LX), the auxiliary lumen (LX) defining a third space of the cannula and comprising an outlet opening into the cavity , the movement means making it possible to deploy the stop in the cavity , via the outlet of the auxiliary lumen (LX), in order to ensure that the cannula is locked in position in the cavity , the outlet of the auxiliary lumen (LX) being arranged at a predetermined distance (d) from the outlet of the accessory reperfusion lumen (LA) such that when the stop locks the cannula in position in the cavity , the outlet of the accessory reperfusion lumen (LA) is oriented in the cavity such that the collected fluid (F1) is discharged in the second direction. - a main lumen (LP) defining a first space of the cannula for the fluid (F1) to flow in a first direction; and - an accessory reperfusion lumen (LA) defining a second space of the cannula and comprising: o an inlet for collecting a portion of the fluid (F1) flowing in the first direction; o an angled portion for changing the direction of flow of the fluid (F1) collected by the accessory reperfusion lumen (LA); and o an outlet for discharging the collected fluid (F1) in a second direction into the cavity , characterized in that the cannula comprises a device for positioning the cannula in the cavity , the positioning device comprising a stop and movement means configured to move said stop along an auxiliary lumen (LX), the auxiliary lumen (LX) defining a third space of the cannula and comprising an outlet opening into the cavity , o an inlet for collecting a portion of the fluid (F1) flowing in the first direction; o an angled portion for changing the direction of flow of the fluid (F1) collected by the accessory reperfusion lumen (LA); and o an outlet for discharging the collected fluid (F1) in a second direction into the cavity , the movement means making it possible to deploy the stop in the cavity , via the outlet of the auxiliary lumen (LX), in order to ensure that the cannula is locked in position in the cavity , the outlet of the auxiliary lumen (LX) being arranged at a predetermined distance (d) from the outlet of the accessory reperfusion lumen (LA) such that when the stop locks the cannula in position in the cavity , the outlet of the accessory reperfusion lumen (LA) is oriented in the cavity such that the collected fluid (F1) is discharged in the second direction.
A pressure vessel system, comprising: a pressure element configured to store compressed gas; a shell configured to enclose the pressure element and capture the compressed gas that permeates from the pressure element ; an end fitting extending into a cavity of the pressure element and from the pressure element through the shell , the end fitting comprising: a stem that extends out from the shell in one direction and into the cavity of the pressure element in an opposite direction; and a cap that surrounds the pressure element and the stem at a location external to the pressure element ; and a retention component configured to sustain engagement of the end fitting with at least one of the pressure element or the shell below a predetermined pressure threshold; wherein the retention component comprises: a tether with a first end coupled to the stem at a location external to the shell and a second end coupled to a curved portion of another pressure element interior to the shell . a pressure element configured to store compressed gas; a shell configured to enclose the pressure element and capture the compressed gas that permeates from the pressure element ; an end fitting extending into a cavity of the pressure element and from the pressure element through the shell , the end fitting comprising: a stem that extends out from the shell in one direction and into the cavity of the pressure element in an opposite direction; and a cap that surrounds the pressure element and the stem at a location external to the pressure element ; and a stem that extends out from the shell in one direction and into the cavity of the pressure element in an opposite direction; and a cap that surrounds the pressure element and the stem at a location external to the pressure element ; and a retention component configured to sustain engagement of the end fitting with at least one of the pressure element or the shell below a predetermined pressure threshold; wherein the retention component comprises: a tether with a first end coupled to the stem at a location external to the shell and a second end coupled to a curved portion of another pressure element interior to the shell .
A method for controlling an inverter to prevent an unnecessary fan trip, the method comprising: receiving a fan current (S51); when the fan current is above a high trip level or is below a low trip level (S52), incrementing an error count (S53); when the error count reaches an error count maximum value (S54), initializing the error count (S55); characterized in that when the error count reaches the error count maximum value, incrementing a trip count; when the fan current is between the low trip level and the high trip level, incrementing a none error count (S58); when the none error count reaches a none error count maximum value (S59), initializing the trip count (S60); and when the trip count reaches a trip count maximum value (S56), generating a fan trip signal (S57) and stopping an operation of the inverter. receiving a fan current (S51); when the fan current is above a high trip level or is below a low trip level (S52), incrementing an error count (S53); when the error count reaches an error count maximum value (S54), initializing the error count (S55); characterized in that when the error count reaches the error count maximum value, incrementing a trip count; when the fan current is between the low trip level and the high trip level, incrementing a none error count (S58); when the none error count reaches a none error count maximum value (S59), initializing the trip count (S60); and when the trip count reaches a trip count maximum value (S56), generating a fan trip signal (S57) and stopping an operation of the inverter.
An optical device for an illuminator device, configured to modify the distribution of light produced by a light source, the optical device comprising: - a first surface for acting as a light-ingress surface for receiving light from the light source, and - a second surface for acting as a light-egress surface for the light received at the first surface, wherein the first surface comprises a plurality of convex areas and the second surface comprises a plurality of elevations so that the convex areas are configured to direct the light received at the first surface to at least some of the elevations, and each of the at least some of the elevations is configured to turn at least a part of the light directed to the elevation under consideration sideward with respect to a height direction of the elevation under consideration, characterized in that each of the at least some of the elevations is tapering towards a tip of the elevation under consideration, and the tip has a shape of a spherical calotte and another part of the elevation under consideration has a conical shape. - a first surface for acting as a light-ingress surface for receiving light from the light source, and - a second surface for acting as a light-egress surface for the light received at the first surface,
A monitoring well installation comprising metallic casing running down from the surface into a borehole and a sealing material plug provided downhole in the borehole for blocking the interior of the casing and sealing the borehole against the egress of fluid from a zone below the plug , wherein there is an axial spacing between adjacent casing portions in the region of the plug such that there is an uncased length of borehole in which the material of the plug seals against the formation (F) in which the borehole is drilled, and wherein there is provided a sensing tool located below the plug for sensing at least one parameter below the plug and a communication arrangement for use in transmitting data from the sensing tool towards the surface, characterized in that the communication arrangement comprises: across plug communication apparatus for facilitating transmission of signals carrying data across the plug towards the surface, wherein a break is provided in the metallic casing on at least one side of the axial spacing so forming a casing section which is not galvanically connected to the remainder of the casing on the respective side of the axial spacing and the across plug communication apparatus comprises said casing section as an electrode for applying electrical signals to the formation (F) and/or for picking up electrical signals from the formation (F). across plug communication apparatus for facilitating transmission of signals carrying data across the plug towards the surface, wherein a break is provided in the metallic casing on at least one side of the axial spacing so forming a casing section which is not galvanically connected to the remainder of the casing on the respective side of the axial spacing and the across plug communication apparatus comprises said casing section as an electrode for applying electrical signals to the formation (F) and/or for picking up electrical signals from the formation (F).
The compound varenicline, or a pharmaceutically acceptable salt thereof, for use in the treatment of ocular discomfort, the treatment comprising the local administration of a therapeutically effective amount of varenicline, or a pharmaceutically acceptable salt thereof, in alternating nostrils of an individual in need thereof; wherein the ocular discomfort is a symptom of dry eye disease, or is associated with blepharitis, meibomian gland dysfunction, allergic conjunctivitis, ocular surface toxicity, ocular surface irritation, or eyelid disorders.
A grease composition for constant velocity joints, comprising; (a) a base oil, (b) a diurea thickener, (c) a benzotriazole derivative represented by formula : wherein R 1 represents an alkyl group having 1 to 18 carbon atoms and R 3 represents CH 2 NR 5 R 6 in which R 5 and R 6 are each independently an alkyl group having 1 to 18 carbon atoms, and (d) an amine salt of an acid phosphate, wherein the benzotriazole derivative (c) is contained in an amount of 0.2 to 20 mass% based on the total mass of the composition, wherein the amine salt of acid phosphate (d) is contained in an amount of 0.05 to 10 mass% based on the total mass of the composition. (a) a base oil, (b) a diurea thickener, (c) a benzotriazole derivative represented by formula : wherein R 1 represents an alkyl group having 1 to 18 carbon atoms and R 3 represents CH 2 NR 5 R 6 in which R 5 and R 6 are each independently an alkyl group having 1 to 18 carbon atoms, and (d) an amine salt of an acid phosphate,