mhurhangee/patent-ind-claim-en huggingface dataset:
A genetically modified mouse, comprising: a null mutation in the mouse SIRPα gene at the mouse SIRPα gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human SIRPα protein and is operably linked to an endogenous mouse SIRPα gene promoter at the mouse SIRPα gene locus; and a null mutation in the mouse IL-15 gene at the mouse IL-15 gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human IL-15 protein and is operably linked to an endogenous mouse IL-15 gene promoter at the mouse IL-15 gene locus, wherein the genetically modified mouse expresses the human SIRPα protein and the human IL-15 protein, wherein the genetically modified mouse is immunodeficient and comprises a Rag2 gene knock-out and an IL2rg gene knock-out, a Rag2 gene knock-out, or an IL2rg gene knock-out, and wherein when the genetically modified mouse comprises an engraftment of human hematopoietic cells, the genetically modified mouse comprises human intraepithelial lymphocytes (IELs) in the lung, or small intestine and Peyer's patches, of the genetically modified mouse. a null mutation in the mouse SIRPα gene at the mouse SIRPα gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human SIRPα protein and is operably linked to an endogenous mouse SIRPα gene promoter at the mouse SIRPα gene locus; and a null mutation in the mouse IL-15 gene at the mouse IL-15 gene locus and a nucleic acid sequence incorporated into the genome of the genetically modified mouse, which sequence encodes a human IL-15 protein and is operably linked to an endogenous mouse IL-15 gene promoter at the mouse IL-15 gene locus, wherein the genetically modified mouse expresses the human SIRPα protein and the human IL-15 protein, wherein the genetically modified mouse is immunodeficient and comprises a Rag2 gene knock-out and an IL2rg gene knock-out, a Rag2 gene knock-out, or an IL2rg gene knock-out, and wherein when the genetically modified mouse comprises an engraftment of human hematopoietic cells, the genetically modified mouse comprises human intraepithelial lymphocytes (IELs) in the lung, or small intestine and Peyer's patches, of the genetically modified mouse.
Composition containing - a silicone-free wax (W) - a binder (B) - one or more pigment(s) and/or filler(s) (PF1) having an average particle size from 0.1 to 1.0 μm in a total amount of 8.0 to 55 wt%; - one or more pigment(s) and/or filler(s) (PF2) having an average particle size greater than 1.0 to 10 μm in a total amount of 5.0 to 40 wt%; - one or more pigment(s) and/or filler(s) (PF3) having an average particle size greater than 10 to 40 μm in a total amount of 3.0 to 30 wt%; relative in each case to the solids content of the composition, wherein - the composition is free from silicone-containing oils and waxes, and contains - a pigment volume concentration according to EN ISO 4618-1 from 15% to 60%, wherein the additives contained in the formulation and the solvents, water and wax are not taken into account for the calculation. - a silicone-free wax (W) - a binder (B) - one or more pigment(s) and/or filler(s) (PF1) having an average particle size from 0.1 to 1.0 μm in a total amount of 8.0 to 55 wt%; - one or more pigment(s) and/or filler(s) (PF2) having an average particle size greater than 1.0 to 10 μm in a total amount of 5.0 to 40 wt%; - one or more pigment(s) and/or filler(s) (PF3) having an average particle size greater than 10 to 40 μm in a total amount of 3.0 to 30 wt%; relative in each case to the solids content of the composition, wherein - the composition is free from silicone-containing oils and waxes, and contains - a pigment volume concentration according to EN ISO 4618-1 from 15% to 60%, wherein the additives contained in the formulation and the solvents, water and wax are not taken into account for the calculation.
Method for manufacturing components of an outer skin of a vehicle with a film , which is back-moulded at least from one side - front side (V) or rear side (R) - with clear plastics material, wherein the film is subjected to a thermoforming process in order to generate the desired three-dimensional form, and the film is subjected to further steps for preparation of the back-moulding, - wherein the film is at least partially provided with a colour layer , - and the film comprises regions through which other colours are intended to show or electromagnetic waves are intended to pass and which consist of specially embossed geometries, such as indentations, elevations, wherein the regions are prepared by punched-out portions from the film , - wherein the prepared coloured film with its punched-out portions is first overmoulded with a glass-clear plastics layer , in which the specially embossed geometries are then present, - and components which have a coloured or luminous visual appearance towards the outside are inserted into the punched-out portions , wherein the components show through punched-out portions of the film and of the glass-clear injection-moulded encapsulation of the film and can be seen from the outside, that is to say from the front side (V). - wherein the film is at least partially provided with a colour layer , - and the film comprises regions through which other colours are intended to show or electromagnetic waves are intended to pass and which consist of specially embossed geometries, such as indentations, elevations, wherein the regions are prepared by punched-out portions from the film , - wherein the prepared coloured film with its punched-out portions is first overmoulded with a glass-clear plastics layer , in which the specially embossed geometries are then present, - and components which have a coloured or luminous visual appearance towards the outside are inserted into the punched-out portions , wherein the components show through punched-out portions of the film and of the glass-clear injection-moulded encapsulation of the film and can be seen from the outside, that is to say from the front side (V).
A delivery device configured for delivering an interventional device to a targeted treatment area within a body, the delivery device comprising: an outer guide catheter having a proximal end and a distal end; an inner sleeve positioned radially within the outer guide catheter and configured to be translatable within the outer guide catheter ; a delivery catheter positioned radially within the inner sleeve and configured to be translatable within the inner sleeve , the delivery catheter being configured to enable delivery of an interventional device through the inner sleeve and outer guide catheter to a targeted treatment area within a body; and at least one sensor coupled to one or more of the outer guide catheter , inner sleeve , or delivery catheter , the at least one sensor being configured to enable monitoring of one or more hemodynamic properties of the targeted treatment area during deployment of an interventional device using the delivery device , wherein: the at least one sensor includes one or more sensor wires routed in a routing channel formed in and extending longitudinally along a wall of the outer guide catheter , inner sleeve , or delivery catheter ; and the one or more sensor wires are routed through the delivery catheter , the inner sleeve , or the outer guide catheter so as to be distally extendable beyond the delivery catheter , the inner sleeve , or the outer guide catheter respectively. an outer guide catheter having a proximal end and a distal end; an inner sleeve positioned radially within the outer guide catheter and configured to be translatable within the outer guide catheter ; a delivery catheter positioned radially within the inner sleeve and configured to be translatable within the inner sleeve , the delivery catheter being configured to enable delivery of an interventional device through the inner sleeve and outer guide catheter to a targeted treatment area within a body; and at least one sensor coupled to one or more of the outer guide catheter , inner sleeve , or delivery catheter , the at least one sensor being configured to enable monitoring of one or more hemodynamic properties of the targeted treatment area during deployment of an interventional device using the delivery device , wherein: the at least one sensor includes one or more sensor wires routed in a routing channel formed in and extending longitudinally along a wall of the outer guide catheter , inner sleeve , or delivery catheter ; and the one or more sensor wires are routed through the delivery catheter , the inner sleeve , or the outer guide catheter so as to be distally extendable beyond the delivery catheter , the inner sleeve , or the outer guide catheter respectively. the at least one sensor includes one or more sensor wires routed in a routing channel formed in and extending longitudinally along a wall of the outer guide catheter , inner sleeve , or delivery catheter ; and the one or more sensor wires are routed through the delivery catheter , the inner sleeve , or the outer guide catheter so as to be distally extendable beyond the delivery catheter , the inner sleeve , or the outer guide catheter respectively.
A spectral property acquisition apparatus comprising: a first conveying device configured to convey an object in predetermined conveying direction; a color data acquisition device including a plurality of spectroscopic sensors in the conveying direction, the plurality of spectroscopic sensors being configured to receive light emitted and reflected by the object to acquire color data on the object; a second conveying device configured to convey the color data acquisition device in a direction orthogonal to the conveying direction; and a controller configured to estimate a spectral property of the object based on the color data, wherein the controller is configured to control the first conveying device so as to generate predetermined tension for the object in a color data acquisition area in which the color data on the object is acquired; characterized in that the first conveying device includes a first nip roller and a second nip roller, the first nip roller and the second nip roller each having a different driving force, the first nip roller is located upstream of the conveying direction in the color data acquisition area, the second nip roller is located downstream of the color data acquisition area in the conveying direction, and the second nip roller includes a torque limiter. a first conveying device configured to convey an object in predetermined conveying direction; a color data acquisition device including a plurality of spectroscopic sensors in the conveying direction, the plurality of spectroscopic sensors being configured to receive light emitted and reflected by the object to acquire color data on the object; a second conveying device configured to convey the color data acquisition device in a direction orthogonal to the conveying direction; and a controller configured to estimate a spectral property of the object based on the color data, wherein the controller is configured to control the first conveying device so as to generate predetermined tension for the object in a color data acquisition area in which the color data on the object is acquired; characterized in that the first conveying device includes a first nip roller and a second nip roller, the first nip roller and the second nip roller each having a different driving force, the first nip roller is located upstream of the conveying direction in the color data acquisition area, the second nip roller is located downstream of the color data acquisition area in the conveying direction, and the second nip roller includes a torque limiter.
Gas turbine exhaust-gas cone having an outer wall which is provided with a multiplicity of cutouts, having a honeycomb structure layer which is arranged on the inner side of the outer wall and extends along the inner side of the outer wall , having an inner wall which extends substantially parallel to the outer wall and is connected to the honeycomb structure , having at least one ring chamber which is adjacent to the inner wall and is centred with respect to a central axis , wherein the ring chamber is subdivided into multiple chambers by means of at least one separating wall , wherein the separating wall is manufactured from a sheet-like material, characterized in that the inner wall is provided with passage cutouts which connect the region of the honeycomb structure to the ring chamber , wherein the ring chamber is subdivided by means of the separating wall in a circumferential direction, and the separating wall comprises a multiplicity of elevated regions and/or set back regions with an elliptic paraboloidal structure, which are formed in a uniform arrangement by deformation of the sheet-like material.
Method for the production of contact elements for electrical contacts from an endless contact strip, which contact elements have a nominal cross-section, a nominal shape and/or a nominal welding nipple geometry, having the following method steps: - providing an endless strip with a basic shape deviating from the nominal cross-section, nominal shape and/or nominal welding nipple geometry, - cutting a strip piece forming the contact element from the endless strip and forming the strip piece into the contact element having the nominal cross-section, the nominal shape and/or the nominal welding nipple geometry, and - applying the contact element to a carrier strip , wherein the cutting of the strip piece from the endless strip takes place in a first working step and the forming of the strip piece into the contact element with the nominal cross-section, the nominal shape and/or the nominal welding geometry takes place in a subsequent, second working step, characterized in that a joining foil , in particular a weldable or solderable foil, is applied to the strip piece during forming. - providing an endless strip with a basic shape deviating from the nominal cross-section, nominal shape and/or nominal welding nipple geometry, - cutting a strip piece forming the contact element from the endless strip and forming the strip piece into the contact element having the nominal cross-section, the nominal shape and/or the nominal welding nipple geometry, and - applying the contact element to a carrier strip , wherein the cutting of the strip piece from the endless strip takes place in a first working step and the forming of the strip piece into the contact element with the nominal cross-section, the nominal shape and/or the nominal welding geometry takes place in a subsequent, second working step,
A radiation therapy treatment system , comprising: a therapy generator ; and a therapy output ; a therapy controller system coupled to the radiation therapy generator and the radiation therapy output , the radiation therapy controller system comprising an imaging input , the imaging input configured to receive reference imaging information, the therapy controller system configured to: generate a two-dimensional projection image, the two-dimensional projection image corresponding to a specified projection direction, the two-dimensional projection image being generated based on imaging information acquired according to the specified projection direction via nuclear magnetic resonance projection imaging, the specified projection direction including a path traversing at least a portion of an imaging subject; determine a change between the generated two-dimensional projection image and the reference imaging information; and control delivery of the radiation therapy at the radiation therapy output at least in part using the determined change between the obtained two-dimensional projection image and the reference imaging information. a therapy generator ; and a therapy output ; a therapy controller system coupled to the radiation therapy generator and the radiation therapy output , the radiation therapy controller system comprising an imaging input , the imaging input configured to receive reference imaging information, the therapy controller system configured to: generate a two-dimensional projection image, the two-dimensional projection image corresponding to a specified projection direction, the two-dimensional projection image being generated based on imaging information acquired according to the specified projection direction via nuclear magnetic resonance projection imaging, the specified projection direction including a path traversing at least a portion of an imaging subject; determine a change between the generated two-dimensional projection image and the reference imaging information; and control delivery of the radiation therapy at the radiation therapy output at least in part using the determined change between the obtained two-dimensional projection image and the reference imaging information. generate a two-dimensional projection image, the two-dimensional projection image corresponding to a specified projection direction, the two-dimensional projection image being generated based on imaging information acquired according to the specified projection direction via nuclear magnetic resonance projection imaging, the specified projection direction including a path traversing at least a portion of an imaging subject; determine a change between the generated two-dimensional projection image and the reference imaging information; and control delivery of the radiation therapy at the radiation therapy output at least in part using the determined change between the obtained two-dimensional projection image and the reference imaging information.
An aqueous suspension formulation for use in the treatment or prevention of an inflammatory disease or an infectious disease, wherein the aqueous suspension formulation comprises nanoparticles of a macrolide antibiotic and a dispersion stabilizer comprising (a) polyoxyethylene hydrogenated castor oil 60 as a surfactant and (b) methyl cellulose and/or hydroxypropyl methyl cellulose as viscosity modifier; the nanoparticles have an average particle diameter of 300 nm or less and a 90% diameter of 1500 nm or less, the average particle diameter is an arithmetic mean diameter in a particle diameter distribution measured by dynamic light scattering photon correlation spectroscopy, and the aqueous suspension formulation is an ocular topical formulation.
An airfoil for a gas turbine engine comprising: an airfoil section extending from a root section , the airfoil section extending between a leading edge (LE) and a trailing edge (TE) in a chordwise direction (C) and extending between a tip portion and the root section in a radial direction (R), and the airfoil section defining a pressure side (P) and a suction side (S) separated in a thickness direction (T); wherein the airfoil section includes a metallic sheath that receives a composite core , and the core includes first and second ligaments received in respective internal channels defined by the sheath such that the first and second ligaments are spaced apart along the root section with respect to the chordwise direction (C); wherein each one of the first and second ligaments includes at least one interface portion in the root section , and the at least one interface portion of the first ligament and the at least one interface portion of the second ligament define respective sets of bores that receive a retention pin ; wherein the core includes a ligament bridge that interconnects an adjacent pair of the ligaments at a position along the airfoil section ; and characterized in that the ligament bridge is dimensioned to abut against opposing ribs of a first skin of the sheath to limit radial movement of the core relative to the sheath , the opposing ribs bounding the internal channels . an airfoil section extending from a root section , the airfoil section extending between a leading edge (LE) and a trailing edge (TE) in a chordwise direction (C) and extending between a tip portion and the root section in a radial direction (R), and the airfoil section defining a pressure side (P) and a suction side (S) separated in a thickness direction (T); wherein the airfoil section includes a metallic sheath that receives a composite core , and the core includes first and second ligaments received in respective internal channels defined by the sheath such that the first and second ligaments are spaced apart along the root section with respect to the chordwise direction (C); wherein each one of the first and second ligaments includes at least one interface portion in the root section , and the at least one interface portion of the first ligament and the at least one interface portion of the second ligament define respective sets of bores that receive a retention pin ; wherein the core includes a ligament bridge that interconnects an adjacent pair of the ligaments at a position along the airfoil section ; and characterized in that the ligament bridge is dimensioned to abut against opposing ribs of a first skin of the sheath to limit radial movement of the core relative to the sheath , the opposing ribs bounding the internal channels .
A method of preparing a magnetic particle comprising a polymer matrix (P) and at least one magnetic core (M), preferably at least two magnetic cores (M), wherein the polymer matrix (P) comprises at least one hypercrosslinked polymer, wherein the method comprises: (i) providing at least one magnetic core (M), preferably at least two magnetic cores (M), (ii) providing polymer precursor molecules, (iii) polymerizing the polymer precursor molecules according to (ii) in the presence of the at least one magnetic core (M), thereby forming a particle comprising the at least one magnetic core (M), preferably the at least two magnetic cores (M), embedded in a polymer matrix (P1), and (iv) hypercrosslinking the polymer matrix (P1) of the polymer particle obtained in (iii) via a Friedel-Crafts reaction, wherein the reaction is carried out at a temperature equal to or less than 80°C, to give the magnetic particle, wherein the magnetic particle has a particle size in the range of from 5 to 40 micrometers, wherein the reaction in (iv) is not carried out in a solvent comprising dichloroethane or other organic halides; wherein the reaction in (iv) is carried out for a reaction time of 2 h or less; wherein the reaction in (iv) is carried out in a solvent comprising at least THF, acetonitrile, DMF, dioxane or toluol; wherein the hypercrosslinking in (iv) is carried out in the presence of a catalyst selected from the group consisting of a Lewis acid. (i) providing at least one magnetic core (M), preferably at least two magnetic cores (M), (ii) providing polymer precursor molecules, (iii) polymerizing the polymer precursor molecules according to (ii) in the presence of the at least one magnetic core (M), thereby forming a particle comprising the at least one magnetic core (M), preferably the at least two magnetic cores (M), embedded in a polymer matrix (P1), and (iv) hypercrosslinking the polymer matrix (P1) of the polymer particle obtained in (iii) via a Friedel-Crafts reaction, wherein the reaction is carried out at a temperature equal to or less than 80°C,