mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of Formula 1 or its pharmaceutically acceptable salt: wherein, W is N, R 1 is hydrogen; a C 1-6 alkyl group; a C 1-6 alkoxy group; an amino group; a C 1-6 alkylamino group; a C 1-6 alkylthio group; or a halogen group, R 2 is a C 3-8 cycloalkyl group or a phenyl group, R 3 is a C 1-6 alkyl group or a C 3-8 cycloalkyl group, and Cy is a group of the following Formula A or B, where * in Formulas A and B represents the position attached to the compound of Formula 1 W is N, R 1 is hydrogen; a C 1-6 alkyl group; a C 1-6 alkoxy group; an amino group; a C 1-6 alkylamino group; a C 1-6 alkylthio group; or a halogen group, R 2 is a C 3-8 cycloalkyl group or a phenyl group, R 3 is a C 1-6 alkyl group or a C 3-8 cycloalkyl group, and Cy is a group of the following Formula A or B, where * in Formulas A and B represents the position attached to the compound of Formula 1
A humanized antibody, or a binding fragment thereof, wherein the humanized antibody or a binding fragment thereof binds human ENO1, wherein the antibody or a binding fragment thereof comprises a light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence LCDR1 of RASENIYSYLT (SEQ ID NO:6) and a CDR2 having the amino acid sequence LCDR2 of NAKTLPE (SEQ ID NO:7) and a CDR3 having the amino acid sequence LCDR3 of QHHYGTPYT (SEQ ID NO:8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence HCDR1 of GYTFTSCVMN (SEQ ID NO:3), a CDR2 having the amino acid sequence HCDR2 of YINPYNDGTKYNEKFKG (SEQ ID NO:4) and a CDR3 having the amino acid sequence HCDR3 of EGFYYGNFDN (SEQ ID NO:5), wherein framework regions in the light chain variable region (VL) domain and the heavy chain variable region (VH) domain comprise amino acid sequences from a human immunoglobulin, wherein the framework regions in the light chain variable region (VL) domain are from a kappa chain.
Method for sealing an exhaust gas space of a heater relative to a surrounding installation space , wherein in the exhaust gas space a condensate is guided from a heat exchanger to a drain with a siphon having a float and a closing function, wherein the condensate , on its way to the siphon , is first collected in a liquid reservoir in a pressure damping basin , wherein furthermore a partition is immersed in the liquid reservoir , such that condensate can flow only under a lower edge of the partition through to the siphon , and wherein furthermore an opening which has a smaller opening cross-section than a free cross-section in the liquid reservoir in the pressure damping basin below the partition is made in the partition wall above a surface of the liquid reservoir as the only connection above the surface of the liquid reservoir in the pressure damping basin between a burner-side exhaust gas region and a siphon-side exhaust gas region .
A system for cooling a liquid cryogenic fluid user with an inert and non-pressurized liquid cryogen in 120K to 200K temperature range comprising: • a primary cooling loop composed at least of a main cryogenic tank , one sub-cooler and a recirculation pump , and designed for operation with a first liquid cryogenic fluid under pressure, wherein • the primary cooling loop is connected to a secondary cooling loop composed of a liquid phase separator connected to the liquid cryogenic fluid user, the liquid phase separator housing a heat exchanger and designed to be operated at very low pressure with a second liquid cryogenic fluid, • the secondary cooling loop is connected to a gaseous buffer tank thereby allowing the addition or removal of the second liquid cryogenic fluid from Secondary cooling loop during a cool-down and/or a warm-up phase, and • the system is configured to condense the second liquid cryogenic fluid using the pressurized first liquid cryogenic fluid. • a primary cooling loop composed at least of a main cryogenic tank , one sub-cooler and a recirculation pump , and designed for operation with a first liquid cryogenic fluid under pressure, wherein • the primary cooling loop is connected to a secondary cooling loop composed of a liquid phase separator connected to the liquid cryogenic fluid user, the liquid phase separator housing a heat exchanger and designed to be operated at very low pressure with a second liquid cryogenic fluid, • the secondary cooling loop is connected to a gaseous buffer tank thereby allowing the addition or removal of the second liquid cryogenic fluid from Secondary cooling loop during a cool-down and/or a warm-up phase, and • the system is configured to condense the second liquid cryogenic fluid using the pressurized first liquid cryogenic fluid.
A cannula for perfusion of a donor organ, the cannula comprising: a first clamping surface ; a second clamping surface opposed to the first clamping surface , the first and second clamping surfaces being configured to cooperate to secure an end of the vasculature therebetween; a tissue supporting surface outside of the second clamping surface and configured to retain tissue outside of the first clamping surface and the second clamping surface ; a longitudinal stiffening rib opposite the tissue supporting surface that stiffens the tissue supporting surface ; and a strap to restrain the cannula in a closed position, characterized by : the cannula comprising a first circumferential portion and a second circumferential portion that mutually cooperate to support a circumference of the vasculature and to form the second clamping surface ; and the stiffening rib comprising a recess that is opposite the tissue supporting surface and is configured to limit lateral movement of the strap . a first clamping surface ; a second clamping surface opposed to the first clamping surface , the first and second clamping surfaces being configured to cooperate to secure an end of the vasculature therebetween; a tissue supporting surface outside of the second clamping surface and configured to retain tissue outside of the first clamping surface and the second clamping surface ; a longitudinal stiffening rib opposite the tissue supporting surface that stiffens the tissue supporting surface ; and a strap to restrain the cannula in a closed position, characterized by : the cannula comprising a first circumferential portion and a second circumferential portion that mutually cooperate to support a circumference of the vasculature and to form the second clamping surface ; and the stiffening rib comprising a recess that is opposite the tissue supporting surface and is configured to limit lateral movement of the strap . the cannula comprising a first circumferential portion and a second circumferential portion that mutually cooperate to support a circumference of the vasculature and to form the second clamping surface ; and the stiffening rib comprising a recess that is opposite the tissue supporting surface and is configured to limit lateral movement of the strap .
An eluting matrix, said matrix comprising at least one cell, wherein said cell is encapsulated in a CXCL12 polypeptide-eluting biocompatible polymer-matrix, and further wherein the concentration of CXCL12 in the matrix is at least 100 ng/mL so as to repel effector T-cells surrounding said matrix upon implantation.
Fastening device for fastening an attachment part to a profile of a railing, comprising a first gripping means , a second gripping means , a fastening means and a spreading means , wherein the first gripping means comprises a first gripping element and the second gripping means comprises a second gripping element , wherein the first gripping means is pivotably mounted on the second gripping means , wherein the spreading means is designed to trigger a pivoting of the first gripping means relative to the second gripping means , wherein a distance between the first gripping element and the second gripping element is changed during the pivoting, wherein the second gripping means comprises a receiving region for the fastening means , wherein the fastening means can be introduced into the receiving region , and wherein the fastening means is designed to be fastened to the attachment part , characterized in that the gripping elements can be introduced into undercuts of a groove of a profile and are held there by a clamping force exerted by the spreading means.
A spread-spectrum-signal reception apparatus to receive a signal having a spectrum spread with a spread code, the spread-spectrum-signal reception apparatus comprising a signal processing unit and a control unit , the signal processing unit comprising a spreading-code generating unit adapted to generate a spread code and to output a phase state of the spread code; a demodulating unit adapted to demodulate the received signal in accordance with the spread code; a frame synchronizing unit adapted to perform a frame synchronizing process on the demodulated signal to detect and output a frame timing corresponding to a top of a frame of the received signal, and a phase setting unit adapted to perform an initialization of the spread-code generating unit in response to input of an initialization instruction, the frame timing and of the phase state of the spread code; the control unit comprising an initialization determining unit adapted to obtain a phase comparison value that is a value indicating the phase of the spread code at the top of a frame before a timing at which initialization of the phase of the spread code is performed; the initialization determining unit is further adapted to output the initialization instruction including the phase comparison value when having determined that a current time is within a range of a time window defined with respect to the time at which the initialization is performed; wherein the phase setting unit initializes the spread-code generating unit at a timing determined in accordance with the result of a comparison between the phase comparison value included in the initialization instruction and the phase state of the spread code at the frame timing.
A metal gasket bellows seal comprising: a first ply having a first ply first end and a first ply second end separated by a first distance ; a second ply having a second ply first end and a second ply second end separated by a second distance ; and a slip joint forming an area of intentional slip, the slip joint formed by an overlap of the first ply first end and the second ply second end , characterised in that : the second ply is coupled to the first ply at a first location via spot joining to form a weld , wherein the first location is positioned between 150 degrees and 210 degrees from the slip joint such that relative growth on either side of the weld is approximately the same because each side will have a similar amount of material allowed to expand. a first ply having a first ply first end and a first ply second end separated by a first distance ; a second ply having a second ply first end and a second ply second end separated by a second distance ; and a slip joint forming an area of intentional slip, the slip joint formed by an overlap of the first ply first end and the second ply second end , characterised in that : the second ply is coupled to the first ply at a first location via spot joining to form a weld , wherein the first location is positioned between 150 degrees and 210 degrees from the slip joint such that relative growth on either side of the weld is approximately the same because each side will have a similar amount of material allowed to expand.
A method for operating a user equipment, UE, in a UE group including at least two UEs, the method comprising: receiving , from a communications controller, network resources information about an allocation of a first set of network resources to the UE group and a transmission indication, wherein the transmission indication indicates that the UE is selected to transmit in a second set of network resources that is a subset of the first set of network resources; and transmitting , to other UEs in the UE group using a direct mobile communications, DMC, link managed by the communications controller, a first message including a control indicator in a first subset of the second set of network resources, the control indicator indicating scheduling information for a second subset of the second set of network resources, wherein the first subset of the second set of network resources and the second subset of the second set of network resources are non-overlapping, and wherein the second subset of the second set of network resources is for DMC data transmission; wherein the transmitting , to other UEs in the UE group using a DMC link managed by the communications controller, a first message including a control indicator in a first subset of the second set of network resources, characterized by transmitting a difference in the control indicator, wherein the difference in the control indicator comprises a difference between parameters of the control indicator used in a previous transmission and parameters of the control indicator to be used in a current transmission. receiving , from a communications controller, network resources information about an allocation of a first set of network resources to the UE group and a transmission indication, wherein the transmission indication indicates that the UE is selected to transmit in a second set of network resources that is a subset of the first set of network resources; and transmitting , to other UEs in the UE group using a direct mobile communications, DMC, link managed by the communications controller, a first message including a control indicator in a first subset of the second set of network resources, the control indicator indicating scheduling information for a second subset of the second set of network resources, wherein the first subset of the second set of network resources and the second subset of the second set of network resources are non-overlapping, and wherein the second subset of the second set of network resources is for DMC data transmission; wherein the transmitting , to other UEs in the UE group using a DMC link managed by the communications controller, a first message including a control indicator in a first subset of the second set of network resources, characterized by transmitting a difference in the control indicator, wherein the difference in the control indicator comprises a difference between parameters of the control indicator used in a previous transmission and parameters of the control indicator to be used in a current transmission.
A method comprising: when a servo gauge detects less than a threshold amount of change in the material level for a threshold amount of time, responsive to detecting the change that is less than the threshold amount and based on whether a measured level of material in the tank has remained constant or substantially constant for a specified period of time, automatically initiating a test of the servo gauge by causing the servo gauge to attempt to move a displacer of the servo gauge, the servo gauge using a drum to move the displacer in the tank; measuring a torque on the drum by measuring the torque on a shaft that imparts rotation to the drum during or after the attempt to move the displacer; and identifying a mechanical problem with the servo gauge based on the measured torque on the shaft, the mechanical problem including a mechanical failure of one or more components of the servo gauge. when a servo gauge detects less than a threshold amount of change in the material level for a threshold amount of time, responsive to detecting the change that is less than the threshold amount and based on whether a measured level of material in the tank has remained constant or substantially constant for a specified period of time, automatically initiating a test of the servo gauge by causing the servo gauge to attempt to move a displacer of the servo gauge, the servo gauge using a drum to move the displacer in the tank; measuring a torque on the drum by measuring the torque on a shaft that imparts rotation to the drum during or after the attempt to move the displacer; and identifying a mechanical problem with the servo gauge based on the measured torque on the shaft, the mechanical problem including a mechanical failure of one or more components of the servo gauge.
Electric radiant element for energy-efficient heating systems in the low voltage and low voltage range with radiant element , characterized in that the radiant element element comprises a defined number of tubular radiant elements , each of which is electrically and thermally connected to a defined number of heating resistor segments of any material, any shape, power and dimension via connecting means , one segment of an electrical heating resistor arranged between two radiators and the tubular radiators at the ends of the electrical radiator element are electrically connected to electrical connection lines via connecting means .
A signal processing apparatus comprising: an acquisition unit configured to acquire a pulse code modulation, PCM, signal and a direct stream digital, DSD, signal; a PCM upsampling unit configured to upsample the PCM signal to a sampling frequency of the DSD signal; a DSD filter configured to remove a high-frequency component of the DSD signal; a delay amount detection unit configured to analyze a correlation between the DSD signal from which a high-frequency component has been removed and the PCM signal after upsampling, and detect a delay amount; and a crossfade unit configured to adjust timing of the DSD signal and the PCM signal after upsampling by using the detected delay amount and crossfade the DSD signal and the PCM signal after upsampling. an acquisition unit configured to acquire a pulse code modulation, PCM, signal and a direct stream digital, DSD, signal; a PCM upsampling unit configured to upsample the PCM signal to a sampling frequency of the DSD signal; a DSD filter configured to remove a high-frequency component of the DSD signal; a delay amount detection unit configured to analyze a correlation between the DSD signal from which a high-frequency component has been removed and the PCM signal after upsampling, and detect a delay amount; and a crossfade unit configured to adjust timing of the DSD signal and the PCM signal after upsampling by using the detected delay amount and crossfade the DSD signal and the PCM signal after upsampling.
A method for assembling a hemostasis valve, the method comprising: positioning a plunger along a threaded proximal end region of a main body and disposing a first seal member within the threaded proximal end region of the main body; wherein the threaded proximal end region of the main body includes one or more threads and an axial slot extending through the one or more threads; advancing the plunger along the threaded proximal end region of the main body to a position where a proximal end of the plunger is disposed distally of at least a portion of the one or more threads; after advancing the plunger, disposing a nut adjacent to the threaded proximal end region of the main body, the nut having an alignment tab formed thereon; aligning the alignment tab with the axial slot; engaging the nut with the one or more threads while the alignment tab is aligned with the axial slot; and rotating the nut 45-270° relative to the threaded proximal end region of the main body. positioning a plunger along a threaded proximal end region of a main body and disposing a first seal member within the threaded proximal end region of the main body; wherein the threaded proximal end region of the main body includes one or more threads and an axial slot extending through the one or more threads; advancing the plunger along the threaded proximal end region of the main body to a position where a proximal end of the plunger is disposed distally of at least a portion of the one or more threads; after advancing the plunger, disposing a nut adjacent to the threaded proximal end region of the main body, the nut having an alignment tab formed thereon; aligning the alignment tab with the axial slot; engaging the nut with the one or more threads while the alignment tab is aligned with the axial slot; and rotating the nut 45-270° relative to the threaded proximal end region of the main body.
A capacity control valve (V) for controlling a capacity of a fluid, comprising: a valve housing provided with a Pc port , a Pd port and a Ps port; a main valve formed by a main valve seat and a main valve element having a main valve portion , the main valve being capable of closing and opening a communication between the Pc port and the Pd port when the main valve portion of the main valve element driven by a drive force of a solenoid comes into contact with and separates from the main valve seat ; a pressure-sensitive valve which is opened by an ambient pressure; a hollow tube member which forms a part of the pressure-sensitive valve and allows the Pc port to communicate with the Ps port through a hollow communication path formed therein when the pressure-sensitive valve is opened; and an auxiliary communication path which allows the Pc port to communicate with the Ps port independently of the pressure-sensitive valve , wherein the auxiliary communication path is a communication hole which is formed in the hollow tube member and communicates with the hollow communication path , characterized in that the auxiliary communication path is configured to be able to increase a flow path cross-sectional area thereof after the main valve is closed, whereby the main valve element is externally fitted to the hollow tube member with a spring so as to be axially movable, and the main valve element relatively moves with respect to the hollow tube member so as to be capable of closing at least a part of an opening of the communication hole . a valve housing provided with a Pc port , a Pd port and a Ps port; a main valve formed by a main valve seat and a main valve element having a main valve portion , the main valve being capable of closing and opening a communication between the Pc port and the Pd port when the main valve portion of the main valve element driven by a drive force of a solenoid comes into contact with and separates from the main valve seat ; a pressure-sensitive valve which is opened by an ambient pressure; a hollow tube member which forms a part of the pressure-sensitive valve and allows the Pc port to communicate with the Ps port through a hollow communication path formed therein when the pressure-sensitive valve is opened; and an auxiliary communication path which allows the Pc port to communicate with the Ps port independently of the pressure-sensitive valve , wherein the auxiliary communication path is a communication hole which is formed in the hollow tube member and communicates with the hollow communication path , characterized in that the auxiliary communication path is configured to be able to increase a flow path cross-sectional area thereof after the main valve is closed, whereby the main valve element is externally fitted to the hollow tube member with a spring so as to be axially movable, and the main valve element relatively moves with respect to the hollow tube member so as to be capable of closing at least a part of an opening of the communication hole .
A therapeutic nanoparticle comprising: about 5 to about 25 weight percent of an excipient which is a polyanionic polymer; about 0.2 to about 35 weight percent of a therapeutic agent which is docetaxel; and about 35 to about 99.75 weight percent of a biocompatible polymer. about 5 to about 25 weight percent of an excipient which is a polyanionic polymer; about 0.2 to about 35 weight percent of a therapeutic agent which is docetaxel; and about 35 to about 99.75 weight percent of a biocompatible polymer.