mhurhangee/patent-ind-claim-en huggingface dataset:
A computer implemented method for determining a copy number variation of a nucleic acid sequence of interest in a test sample comprising cell-free nucleic acid fragments originating from genomes from cancer and somatic cells, the method comprising: (a) receiving sequence reads obtained by sequencing the cell-free nucleic acid fragments in the test sample; (b) aligning the sequence reads of the cell-free nucleic acid fragments to a reference genome comprising the sequence of interest, thereby providing test sequence tags, wherein the reference genome is divided into a plurality of bins; (c) determining sizes of at least some of the cell-free nucleic acid fragments in the test sample; (d) weighting the test sequence tags based on the sizes of cell-free nucleic acid fragments from which the tags are obtained; (e) calculating coverages for the bins based on the weighted test sequence tags; and (f) identifying a copy number variation in the sequence of interest from the calculated coverages by comparison to a qualified sample; and (g) using a copy number variation in the cancer genome to diagnose cancer, monitor the progress of cancer, and/or determine a treatment for cancer. (a) receiving sequence reads obtained by sequencing the cell-free nucleic acid fragments in the test sample; (b) aligning the sequence reads of the cell-free nucleic acid fragments to a reference genome comprising the sequence of interest, thereby providing test sequence tags, wherein the reference genome is divided into a plurality of bins; (c) determining sizes of at least some of the cell-free nucleic acid fragments in the test sample; (d) weighting the test sequence tags based on the sizes of cell-free nucleic acid fragments from which the tags are obtained; (e) calculating coverages for the bins based on the weighted test sequence tags; and (f) identifying a copy number variation in the sequence of interest from the calculated coverages by comparison to a qualified sample; and (g) using a copy number variation in the cancer genome to diagnose cancer, monitor the progress of cancer, and/or determine a treatment for cancer.
A holographic optical element, comprising: a volume hologram recorded layer containing a photopolymer; and at least one adjacent layer which is in contact with the volume hologram recorded layer and contains a resin, wherein a diffraction grating is formed so as to extend from the volume hologram recorded layer into the adjacent layer , characterized in that the adjacent layer contains cellulose acylate and the cellulose acylate has a benzoyl group. a volume hologram recorded layer containing a photopolymer; and at least one adjacent layer which is in contact with the volume hologram recorded layer and contains a resin, wherein a diffraction grating is formed so as to extend from the volume hologram recorded layer into the adjacent layer , characterized in that the adjacent layer contains cellulose acylate and the cellulose acylate has a benzoyl group.
Method for motion correction of a three-dimensional image dataset reconstructed from a plurality of two-dimensional projection images acquired by an X-ray device , which motion correction relates to a movement in a region under examination of a patient that is covered by the image dataset, wherein - a biplane X-ray device having two acquisition assemblies that measure at an angular offset, in particular of 90°, is used; - in order to acquire the projection images, each of the acquisition assemblies covers an angular range of projection angles, and pairs of projection images of the region under examination are acquired at least substantially simultaneously at each acquisition time instant; - for each pair of projection images, at least one marker object lying in the region under examination and imaged in the projection images is automatically localised in order to determine two-dimensional location information; - three-dimensional position information about the marker object is determined using the acquisition geometries of the particular pair of projection images, which acquisition geometries are defined by the projection angles; - motion information describing a motion profile of the marker object over the acquisition period is ascertained from the position information at different acquisition time instants; and - the motion information is used for motion correction of the image dataset, characterised in that for the marker object, at least one orientation of the marker object is determined as part of the position information on the basis of its shape, and is included in the motion profile. - a biplane X-ray device having two acquisition assemblies that measure at an angular offset, in particular of 90°, is used; - in order to acquire the projection images, each of the acquisition assemblies covers an angular range of projection angles, and pairs of projection images of the region under examination are acquired at least substantially simultaneously at each acquisition time instant; - for each pair of projection images, at least one marker object lying in the region under examination and imaged in the projection images is automatically localised in order to determine two-dimensional location information; - three-dimensional position information about the marker object is determined using the acquisition geometries of the particular pair of projection images, which acquisition geometries are defined by the projection angles; - motion information describing a motion profile of the marker object over the acquisition period is ascertained from the position information at different acquisition time instants; and - the motion information is used for motion correction of the image dataset, characterised in that for the marker object, at least one orientation of the marker object is determined as part of the position information on the basis of its shape, and is included in the motion profile.
A cross-linkable elastomeric thermoplastic polyurethane possessing an elastomeric property such that it exhibits at least 100% elongation without breaking when stretched at room temperature and will at least partially relax when released, that is urea free, isocyanurate free, oxazolinyl free, functional radically-polymerizable pendant group free and having terminal functional radically-polymerizable groups at both ends and having a molecular weight, expressed as number average Mn, of from 12000 to 500000, preferably from 20000 to 200000, obtainable by reacting a polyfunctional isocyanate, a polyfunctional polyol and a monol or monoamine comprising radically-polymerizable unsaturation(s), and a diol chain extender.
A pharmaceutical composition, comprising: furosemide, or a pharmaceutically acceptable salt, hydrate or ester thereof; and tris(hydroxymethyl)aminomethane, wherein the furosemide is present in the pharmaceutical composition at a concentration from about 10 mg/mL to about 30 mg/mL; the tris(hydroxymethyl)aminomethane is present in the pharmaceutical composition at a concentration of less than or equal to 40 mM; and the pharmaceutical composition has a pH value from about 8.0 to about 8.5; the term "about" referring to a +/-10% variation from the nominal value and wherein the pharmaceutical composition has a molar ratio of the tris(hydroxymethyl)aminomethane to the furosemide of less than or equal to 0.8. furosemide, or a pharmaceutically acceptable salt, hydrate or ester thereof; and tris(hydroxymethyl)aminomethane, wherein the furosemide is present in the pharmaceutical composition at a concentration from about 10 mg/mL to about 30 mg/mL; the tris(hydroxymethyl)aminomethane is present in the pharmaceutical composition at a concentration of less than or equal to 40 mM; and the pharmaceutical composition has a pH value from about 8.0 to about 8.5; the term "about" referring to a +/-10% variation from the nominal value and wherein the pharmaceutical composition has a molar ratio of the tris(hydroxymethyl)aminomethane to the furosemide of less than or equal to 0.8.
Container for accommodating pharmaceutical compositions (P), the container being installable in a medical device and comprising a hollow cylindrical body having an open end and a dead end opposite to the open end , the open end being configured for receiving a plunger that is slidable relative to the hollow cylindrical body from the open end towards the dead end , the dead end being closed by a bottom portion , and characterized in that the hollow cylindrical body has a length (L) between 35 mm and 120 mm, an outer diameter (D o ) between 8.65 mm and 30 mm and/or an inner diameter (D l ) between 4.65 mm and 27 mm, with a length to outer diameter ratio between 3:1 and 15:1, wherein the hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material, and wherein the inner surface of the container has an average Zn-leachability of 0.00085 μg/cm 2 or less. the open end being configured for receiving a plunger that is slidable relative to the hollow cylindrical body from the open end towards the dead end , the dead end being closed by a bottom portion , and characterized in that the hollow cylindrical body has a length (L) between 35 mm and 120 mm, an outer diameter (D o ) between 8.65 mm and 30 mm and/or an inner diameter (D l ) between 4.65 mm and 27 mm, with a length to outer diameter ratio between 3:1 and 15:1, wherein the hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material, and wherein the inner surface of the container has an average Zn-leachability of 0.00085 μg/cm 2 or less.
A power tool arranged to operate in at least a first operating mode and a second operating mode, whereby the power tool is operative to: provide a first type of light signal from a light emitting device arranged to light up an object to be processed in case the power tool is set in the first operating mode and a second type of light signal in case the power tool is set in the second operating mode, wherein the power tool further comprising a detachable tool piece holder , characterised in that the tool piece holder comprises at least a first type of marking or second type of marking associated with the first type of light signal or second type of light signal . provide a first type of light signal from a light emitting device arranged to light up an object to be processed in case the power tool is set in the first operating mode and a second type of light signal in case the power tool is set in the second operating mode, wherein the power tool further comprising a detachable tool piece holder , characterised in that the tool piece holder comprises at least a first type of marking or second type of marking associated with the first type of light signal or second type of light signal .
A packet processing method, comprising: determining (S601), by a node in a first network, where the node in the first network is a head node of a segment routing, SR, tunnel established in the first network, a transmission path for a packet, wherein the transmission path comprises a path in the first network and a path traversing a second network; adding (S602), by the node in the first network, path information to the packet based on the determined transmission path, wherein the path information comprises traversal indication information, and the traversal indication information indicates an ingress node and an egress node of the packet in the second network; and sending (S603), by the node in the first network based on the path information, the packet to an ingress node in the second network through the first network, to indicate the ingress node in the second network to transmit the packet by using the egress node specified in the traversal indication information, wherein after receiving the packet, the ingress node in the second network encapsulates (S702) the packet based on the traversal indication information in the packet to change a format of the packet to a format supported by the second network; wherein the first network is an IPv6 network, the second network is an IPv4 network, and the packet is an IPv6 packet. determining (S601), by a node in a first network, where the node in the first network is a head node of a segment routing, SR, tunnel established in the first network, a transmission path for a packet, wherein the transmission path comprises a path in the first network and a path traversing a second network; adding (S602), by the node in the first network, path information to the packet based on the determined transmission path, wherein the path information comprises traversal indication information, and the traversal indication information indicates an ingress node and an egress node of the packet in the second network; and sending (S603), by the node in the first network based on the path information, the packet to an ingress node in the second network through the first network, to indicate the ingress node in the second network to transmit the packet by using the egress node specified in the traversal indication information, wherein after receiving the packet, the ingress node in the second network encapsulates (S702) the packet based on the traversal indication information in the packet to change a format of the packet to a format supported by the second network; wherein the first network is an IPv6 network, the second network is an IPv4 network, and the packet is an IPv6 packet.
Rail element (1; 1'; 1") adapted to co-act with a current collector (2") of an electrically propellable road vehicle for supplying electric power to said vehicle, said rail element being adapted to extend along a road section on which the vehicle is travelling, wherein said rail element is adapted to be located on, or to be partly recessed in, a road surface of said road section, wherein at least two grooves (5a, 5b; 5a', 5b'; 5a", 5b") are formed at least partly by said rail element, wherein two grooves are formed at opposite lateral sides thereof with respective openings of the grooves facing in opposite lateral directions (L 1 , L 2 ) relative a lengthwise direction (LD) of the rail element, wherein at least one electric conductor (8a, 8b; 8a', 8b'; 8a", 8b") is arranged in each of said two grooves, said electric conductors extending along the lengthwise direction of said rail element and being adapted to be put under voltage for supplying said electric power, wherein said two grooves are disposed in a common horizontal plane.
A valve apparatus for supplying pumped fluid by switching between a first flow channel and a second flow channel , the valve apparatus comprising: a housing provided with a first valve chamber connected to the first flow channel and a second valve chamber connected to the second flow channel; a partition wall disposed between the first flow channel and the second flow channel in the housing to separate the first valve chamber from the second valve chamber; and a support portion provided to the housing to support the partition wall, characterized in that the partition wall has: a film-like valve body which is elastically deformed by pressure of the first valve chamber and the second valve chamber so as to open one of the first flow channel and the second flow channel and close the other of the first flow channel and the second flow channel, the valve body having: a membrane portion ; and a hook-shaped engaging portion continuously extending from an outer circumference of the membrane portion; and a frame provided inside the engaging portion and supported by the support portion, wherein the frame is integrally formed of resin or metal, and is higher in stiffness than the valve body. a housing provided with a first valve chamber connected to the first flow channel and a second valve chamber connected to the second flow channel; a partition wall disposed between the first flow channel and the second flow channel in the housing to separate the first valve chamber from the second valve chamber; and a support portion provided to the housing to support the partition wall, characterized in that the partition wall has: a film-like valve body which is elastically deformed by pressure of the first valve chamber and the second valve chamber so as to open one of the first flow channel and the second flow channel and close the other of the first flow channel and the second flow channel, the valve body having: a membrane portion ; and a hook-shaped engaging portion continuously extending from an outer circumference of the membrane portion; and a frame provided inside the engaging portion and supported by the support portion, wherein the frame is integrally formed of resin or metal, and is higher in stiffness than the valve body. a film-like valve body which is elastically deformed by pressure of the first valve chamber and the second valve chamber so as to open one of the first flow channel and the second flow channel and close the other of the first flow channel and the second flow channel, the valve body having: a membrane portion ; and a hook-shaped engaging portion continuously extending from an outer circumference of the membrane portion; and a frame provided inside the engaging portion and supported by the support portion, wherein the frame is integrally formed of resin or metal, and is higher in stiffness than the valve body.
A training appliance for practising combat, contact or grappling sports, comprising a punching bag formed of a shock absorbing filling material disposed in the internal volume of a substantially cylindrical envelope comprising at the lower end a closing wall constituting a bottom wall and at the upper end a second closing wall , a horizontal base for supporting the bag on the ground, adapted to be immobilized on the ground (S), on which the bottom wall of the envelope of the punching bag rests, a mechanical connection allowing pivoting movement of the bag in at least one vertical plane and around the point of contact between the bottom wall and the base , being established between the supporting base and the punching bag , said punching bag further including a first return means to the vertical position, said return means being able to occupy a stable initial state in which the bag is vertical and an unstable final state in which the bag is horizontal and laid on the ground, and a second return means mechanically connected to the framework of the bag , said second return means being fixed to a first attachment member fastened to the bag and more particularly to the framework of said bag and being adapted to be mechanically connected to a second attachment member fastened to a ceiling or a boom or any other structure extending above the bag , said appliance being characterized in that the second return means is formed of a flexible elongate element in the form of a cable housed at least in part on the tube of the punching bag , fixed by one of its ends to an attachment point fastened to the central tube of the punching bag , its other end, external to the bag, being mechanically connected to the second attachment member, said cable being subjected to forces tending to shorten the distance between the second attachment member and said bag and to urge it toward its initial state.
Starting-valve throttle device for delivery a melt from a screw extruder, having - a housing and a housing recess configured therein, - an entry duct for feeding the melt , said entry duct being configured in the housing and opening into the housing recess , - a delivery duct for delivering the melt , said delivery duct being configured in the housing and opening into the housing recess , - an evacuation opening for delivering the melt during a starting procedure of the screw extruder , and - a switching member , -- which is disposed in the housing recess and is repositionable between an evacuation position and a delivery position, -- which in the evacuation position at least in portions configures an evacuation duct for connecting the entry duct to the evacuation opening , -- which in the delivery position configures a passage duct for connecting the entry duct to the delivery duct , - a throttle member arranged in the passage duct , characterized in that the throttle member is repositionable relative to the switching member by means of a throttle member drive and can be actuated independently of the switching member . - a housing and a housing recess configured therein, - an entry duct for feeding the melt , said entry duct being configured in the housing and opening into the housing recess , - a delivery duct for delivering the melt , said delivery duct being configured in the housing and opening into the housing recess , - an evacuation opening for delivering the melt during a starting procedure of the screw extruder , and - a switching member , -- which is disposed in the housing recess and is repositionable between an evacuation position and a delivery position, -- which in the evacuation position at least in portions configures an evacuation duct for connecting the entry duct to the evacuation opening , -- which in the delivery position configures a passage duct for connecting the entry duct to the delivery duct , -- which is disposed in the housing recess and is repositionable between an evacuation position and a delivery position, -- which in the evacuation position at least in portions configures an evacuation duct for connecting the entry duct to the evacuation opening , -- which in the delivery position configures a passage duct for connecting the entry duct to the delivery duct , - a throttle member arranged in the passage duct ,
A method of manufacturing a polymer layer composite, wherein said polymer layer composite has a plurality of polymer layers and wherein at least one polymer layer includes a laser-sensitive component, said method comprising the following steps: A) a first item of personalised information is applied on two or more different polymer layers in the form of a colour ink-jet printed layer realised by means of an ink jet printing process, said colour ink-jet printed layers present on the different polymer layers representing each a partial piece of information of said first item of personalised information, B) the polymer layers having the colour ink-jet printed layers applied thereon are then assembled with the other polymer layers and joined together, with the polymer layers having the colour ink-jet printed layer applied thereon being arranged between two other polymer layers , respectively, C) a second item of personalised information is introduced into the polymer layer composite obtained in step B) by means of laser engraving. A) a first item of personalised information is applied on two or more different polymer layers in the form of a colour ink-jet printed layer realised by means of an ink jet printing process, said colour ink-jet printed layers present on the different polymer layers representing each a partial piece of information of said first item of personalised information, B) the polymer layers having the colour ink-jet printed layers applied thereon are then assembled with the other polymer layers and joined together, with the polymer layers having the colour ink-jet printed layer applied thereon being arranged between two other polymer layers , respectively, C) a second item of personalised information is introduced into the polymer layer composite obtained in step B) by means of laser engraving.