mhurhangee/patent-ind-claim-en huggingface dataset:
An antibody molecule capable of binding dengue virus, comprising: (a) a heavy chain immunoglobulin variable region comprising the amino acid sequence of SEQ ID NO: 1 and (b) a light chain immunoglobulin variable region comprising the amino acid sequence of SEQ ID NO: 2. (a) a heavy chain immunoglobulin variable region comprising the amino acid sequence of SEQ ID NO: 1 and (b) a light chain immunoglobulin variable region comprising the amino acid sequence of SEQ ID NO: 2.
A method for producing acrylic acid, the method comprising: a step of preparing a reaction product including acrylic acid by supplying lactic acid to a reactor and going through a dehydration reaction; a step of supplying a reactor discharge stream including the reaction product to a cooling tower and condensing the result to transfer a lower discharge stream including a condensate to an acrylic acid purification unit and supply a non-condensate discharged as an upper discharge stream to a distillation tower; and in the distillation tower, circulating a lower discharge stream including acrylic acid to the cooling tower, and removing acetaldehyde from an upper discharge stream, wherein an operation pressure of the distillation tower is lower than an operation pressure of the cooling tower. a step of preparing a reaction product including acrylic acid by supplying lactic acid to a reactor and going through a dehydration reaction; a step of supplying a reactor discharge stream including the reaction product to a cooling tower and condensing the result to transfer a lower discharge stream including a condensate to an acrylic acid purification unit and supply a non-condensate discharged as an upper discharge stream to a distillation tower; and in the distillation tower, circulating a lower discharge stream including acrylic acid to the cooling tower, and removing acetaldehyde from an upper discharge stream, wherein an operation pressure of the distillation tower is lower than an operation pressure of the cooling tower.
A method for a user equipment, UE, transmitting uplink signals in a wireless communication system, the method comprising: receiving a physical downlink control channel, PDCCH, including uplink grant; based on the PDCCH including a logical channel priority indication, constructing a protocol data unit, PDU, including data from a radio bearer, RB, with a logical channel priority corresponding to the logical channel priority indication; based on the PDCCH not including a logical channel priority indication, constructing the PDU including data from a RB with a lowest value-te which can be allocated as the logical channel priority indication; and transmitting the PDU to a network based on the uplink grant. receiving a physical downlink control channel, PDCCH, including uplink grant; based on the PDCCH including a logical channel priority indication, constructing a protocol data unit, PDU, including data from a radio bearer, RB, with a logical channel priority corresponding to the logical channel priority indication; based on the PDCCH not including a logical channel priority indication, constructing the PDU including data from a RB with a lowest value-te which can be allocated as the logical channel priority indication; and transmitting the PDU to a network based on the uplink grant.
A trimming device for an electrode film of a secondary battery comprising: a frame for providing a supporting force; a plurality of vertical columns which are supported by the frame, are extended vertically, and can be raised and lowered; a pair of main shafts which are supported horizontally, can rotate axially, and has a plurality of first eccentric axis portions and second eccentric axis portions having mutually different rotational center axes; a driving unit which axially rotates the respective main shafts, simultaneously; an elevation force transfer unit which is installed or a lower portion of the main shaft and coupled with a bottom portion of the vertical column; an upper elevated body which is horizontally installed with an upper portion of the main shaft, is coupled with a top portion of the vertical column, and includes an upper ; a lower elevated body which is arranged under the upper elevated body to be spaced apart therefrom, is supported by the vertical column, is capable of a sliding motion with respect to the vertical column, and includes a lower mold corresponding with the upper mold; a fine adjusting unit which is provided under the elevation force transfer unit and, when necessary, adjusts a gap between the upper mold and the lower mold; a plurality of first connecting arms which are coupled with the first eccentric axis portion of the main shaft, extend downwards to be linked with the elevation force transfer unit , and are driven by the axial rotation of the main shaft so as to provide an up-down motion for the elevation force transfer unit , the fine adjusting , the vertical columns, and the upper elevated body; and a plurality of second connecting arms which are coupled with the second eccentric axis portion of the main shaft , extended upwards to be coupled with the lower elevated body , and driven by the axial rotation of the main shaft so as to raise or lower the lower elevated body.
Combined preparation or composition comprising: - an antibody directed against the HERV-W Envelope protein (HERV-W Env) or fragment thereof; and - a retroviral reverse-transcriptase inhibitory drug; for use as an antiretroviral drug targeting a virus belonging to human endogenous retroviruses type W (HERV-W), wherein said antibody or fragment comprises each of the 6 CDRs as depicted in SEQ ID No: 1 for CDR-L1, SEQ ID No: 2 for CDR-L2 and SEQ ID No: 3 for CDR-L3, SEQ ID No: 4 for CDR-H1, SEQ ID No: 5 for CDR-H2 and SEQ ID No: 6 for CDR-H3. - an antibody directed against the HERV-W Envelope protein (HERV-W Env) or fragment thereof; and - a retroviral reverse-transcriptase inhibitory drug;
Compounds of formulae wherein X is O or NR 13 , wherein R 13 is H, R 1 , R 2 , R 7 and R 8 are independently from each other C 1-20 -alkyl or C 6-14 -aryl, and R 3 and R 4 , R 5 and R 6 , R 9 and R 10 , and R 11 and R 12 together with the C-atoms, to which they are attached, form a C 5-14 -membered ring system selected from the group consisting of wherein the C-atoms marked with a star are the C-atoms to which R 3 and R 4 , R 5 and R 6 , R 9 and R 10 , and R 11 and R 12 are attached, wherein C 6-14 -aryl and the C 5-14 -membered ring system may be substituted with one or more substituents selected from the group consisting of C 1-10 -alkyl, which may be substituted with one or more halogen, and halogen. X is O or NR 13 , wherein R 13 is H, R 1 , R 2 , R 7 and R 8 are independently from each other C 1-20 -alkyl or C 6-14 -aryl, and R 3 and R 4 , R 5 and R 6 , R 9 and R 10 , and R 11 and R 12
A microfluidic collection system for drawing blood from a subject comprising: a. a collector comprising: i. a housing including a lumen ; ii. an actuator configured to be inserted into the lumen at the proximal end of the housing to be movable relative to the housing ; iii. a skin puncture device operably coupled to the actuator, wherein movement of the actuator toward skin of the subject is configured to move the skin puncture device toward the skin; iv. at least one collection site in fluid communication with the lumen, wherein the skin puncture device is configured to extend through the at least one collection site; v. a microfluidic network disposed within the housing and further comprising at least one microfluidic channel; and vi. at least one outflow channel configured to be in fluid communication with the microfluidic network, and characterized in that : the at least one microfluidic channel is an open channel having (a) a wettable surface and (b) a free perimeter portion along a length of the wettable surface ; and b. at least one reservoir configured to be in fluid communication with the at least one outflow channel . a. a collector comprising: i. a housing including a lumen ; ii. an actuator configured to be inserted into the lumen at the proximal end of the housing to be movable relative to the housing ; iii. a skin puncture device operably coupled to the actuator, wherein movement of the actuator toward skin of the subject is configured to move the skin puncture device toward the skin; iv. at least one collection site in fluid communication with the lumen, wherein the skin puncture device is configured to extend through the at least one collection site; v. a microfluidic network disposed within the housing and further comprising at least one microfluidic channel; and vi. at least one outflow channel configured to be in fluid communication with the microfluidic network, and characterized in that : the at least one microfluidic channel is an open channel having (a) a wettable surface and (b) a free perimeter portion along a length of the wettable surface ; and i. a housing including a lumen ; ii. an actuator configured to be inserted into the lumen at the proximal end of the housing to be movable relative to the housing ; iii. a skin puncture device operably coupled to the actuator, wherein movement of the actuator toward skin of the subject is configured to move the skin puncture device toward the skin; iv. at least one collection site in fluid communication with the lumen, wherein the skin puncture device is configured to extend through the at least one collection site; v. a microfluidic network disposed within the housing and further comprising at least one microfluidic channel; and vi. at least one outflow channel configured to be in fluid communication with the microfluidic network, and characterized in that : the at least one microfluidic channel is an open channel having (a) a wettable surface and (b) a free perimeter portion along a length of the wettable surface ; and b. at least one reservoir configured to be in fluid communication with the at least one outflow channel .
An effective amount of 3-[(5-(2,3-dimethoxy-6-methyl 1,4-benzoquinoyl)]-2-nonyl-2-propenoic acid, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, which selectively inhibits the redox function of Ape1/Ref-1, for use in a method for inhibiting malignant peripheral nerve sheath tumors (MPNST) in a subject in need thereof.
An apparatus, comprising: a flexible insertion tube comprising a distal end for insertion into a body cavity; a first internal sensor mounted in the distal end and configured to acquire a first signal from the body cavity during a medical procedure; a second internal sensor mounted in the distal end and configured to acquire a second signal from the body cavity during the medical procedure; a display ; a processor configured to present, on the display, first and second values of generated measurements corresponding to the first and second signals, and to accept an input selecting one of the presented measurements so as to generate a selected measurement; a handle coupled to a proximal end of the flexible insertion tube ; and a haptic feedback device fixedly attached to the handle and configured to provide, under direction of the processor , a tactile feedback in response to the value of the selected measurement while a presentation on the display of the first and the second generated measurements corresponding to the first and second signals deemphasizes the selected measurement. a flexible insertion tube comprising a distal end for insertion into a body cavity; a first internal sensor mounted in the distal end and configured to acquire a first signal from the body cavity during a medical procedure; a second internal sensor mounted in the distal end and configured to acquire a second signal from the body cavity during the medical procedure; a display ; a processor configured to present, on the display, first and second values of generated measurements corresponding to the first and second signals, and to accept an input selecting one of the presented measurements so as to generate a selected measurement; a handle coupled to a proximal end of the flexible insertion tube ; and a haptic feedback device fixedly attached to the handle and configured to provide, under direction of the processor , a tactile feedback in response to the value of the selected measurement while a presentation on the display of the first and the second generated measurements corresponding to the first and second signals deemphasizes the selected measurement.
An electronic apparatus for wireless communications, comprising: processing circuitry , configured to: acquire, from a base station, a pattern index indicating a pattern of a demodulation reference signal, wherein the pattern index comprises RRC layer information and DCI information, the DCI information indicates one particular DMRS pattern of a plurality DMRS patterns configured by the RRC layer information; determine, based on the RRC layer information and the DCI information, a time domain location of the front-loaded demodulation reference signal and a time domain location of an additional demodulation reference signal. acquire, from a base station, a pattern index indicating a pattern of a demodulation reference signal, wherein the pattern index comprises RRC layer information and DCI information, the DCI information indicates one particular DMRS pattern of a plurality DMRS patterns configured by the RRC layer information; determine, based on the RRC layer information and the DCI information, a time domain location of the front-loaded demodulation reference signal and a time domain location of an additional demodulation reference signal.
A multilayer tablet for controlled release of a magnesium salt, oxide or hydroxide, for use in the treatment of states, disorders or conditions caused by magnesium deficiency, comprising: (a) an immediate gastric release layer containing a magnesium oxide or hydroxide, or a magnesium salt selected from magnesium acetate, ascorbate, aspartate, carbonate, chloride, citrate, potassium citrate, dicitrate, fumarate, gluconate, glycerophosphate, lactate, phosphate 5 hydrate, pidolate, propionate and phosphate; a disintegrating agent and a binding polymer; (b) a sustained-release layer containing (i) a polymer able to form a hydrogel matrix when it comes into contact with the fluids of the gastrointestinal tract, (ii) an organic acid able to dissociate in the gastrointestinal fluids, selected from citric acid, tartaric acid, ascorbic acid and lactic acid, and (iii) a magnesium oxide or hydroxide or a magnesium salt as defined above; and optionally, (c) an inert layer inserted between layers (a) and (b), containing a disintegrating agent and a water-insoluble diluent, wherein said layers (a), (b) and (c) are exposed to the gastrointestinal fluids after the tablet is swallowed. (a) an immediate gastric release layer containing a magnesium oxide or hydroxide, or a magnesium salt selected from magnesium acetate, ascorbate, aspartate, carbonate, chloride, citrate, potassium citrate, dicitrate, fumarate, gluconate, glycerophosphate, lactate, phosphate 5 hydrate, pidolate, propionate and phosphate; a disintegrating agent and a binding polymer; (b) a sustained-release layer containing (i) a polymer able to form a hydrogel matrix when it comes into contact with the fluids of the gastrointestinal tract, (ii) an organic acid able to dissociate in the gastrointestinal fluids, selected from citric acid, tartaric acid, ascorbic acid and lactic acid, and (iii) a magnesium oxide or hydroxide or a magnesium salt as defined above; and optionally, (c) an inert layer inserted between layers (a) and (b), containing a disintegrating agent and a water-insoluble diluent,
A medical dressing for use in conjunction with a trocar , wherein said dressing has a distal side provided with a backing layer and an opposing proximal side provided with an adhesive skin contact layer ; said dressing comprising a centrally disposed aperture for receiving a trocar during use, wherein said aperture extends through said backing layer and said adhesive skin contact layer ; said dressing further comprising at least a first flange and a second flange configured to project upwardly from said distal side of said dressing; wherein each one of said at least first and second flanges comprises a respective proximal end portion (105a-c) being attached to said dressing and a respective distal end portion (106a-d) configured to be adhesively attached to a trocar during use.
A method of printing a copy evident document , comprising: creating a void pantograph including a first set of halftone elements and a second set of halftone elements different in modulation from said first set of halftone elements ; converting the first set of halftone elements and the second set of halftone elements into a plurality of halftone holes in a solid white overlay ; merging said overlay with a background image , such that portions of said background image are visible at said halftone hole locations of said overlay when printed, and the overlay reduces the density of the background image ; printing said merged image on print media, wherein said portions of the background image that are printed are printed at locations where said halftone holes locations are present in said overlay creating a copy-evident feature . creating a void pantograph including a first set of halftone elements and a second set of halftone elements different in modulation from said first set of halftone elements ; converting the first set of halftone elements and the second set of halftone elements into a plurality of halftone holes in a solid white overlay ; merging said overlay with a background image , such that portions of said background image are visible at said halftone hole locations of said overlay when printed, and the overlay reduces the density of the background image ; printing said merged image on print media, wherein said portions of the background image that are printed are printed at locations where said halftone holes locations are present in said overlay creating a copy-evident feature .
Nose ring for preventing the sucking of milk from the udders of milk-providing animals by milk-sucking animals, comprising a ring body and a gap interrupting the ring body for receiving a nasal septum of the animal, the ring body having, in the region of the gap , an inner nose portion which comes to rest in an inner nose space of the nose of an animal when the nose ring is fitted to the nose of the animal, characterised in that the ring body has, in the inner nose portion , at least one swivel-blocking projection which projects from the ring body and defines a swivel-blocking position of the nose ring located on the nose of the animal, the nose ring , in its hanging position, hanging down due to gravity and the swivel-blocking projection being freely located in the inner nose space without touching a nose wall delimiting the inner nose space , and wherein dependent on an upward swivelling movement into the swivel-blocking position, the swivel-blocking projection presses against the nose wall of the inner nose space of the nose of the animal.
Windscreen washer system comprising at least one rainwater collection element connected to at least one suction pump for collecting rainwater and conveying the same to a collection tank connected in turn to a pump for delivering windscreen washer fluid characterised in that said rainwater collection element is integrated in at least one wiper blade .
A compound of formula (I-g) or a pharmaceutically acceptable salt thereof wherein R 4 is hydrogen or alkyl; L is -[C(R a R b )] p -; A 1 is Cyc 2 -Q-Cyc 3 ; R a and R b are each independently hydrogen or alkyl; p is 0 or 1; Cyc 2 is aryl or heteroaryl; Q is a bond; Cyc 3 is heteroaryl; M is a bond or -[C(R c R d )] t -[C(R e R f )] k -; A 2 is heterocycle or cycloalkyl; R c , R d , R e , and R f are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently unsubstituted or substituted with substituents independently selected from halogen, =O (oxo), =S (thioxo), cyano, nitro, alkoxyfluoroalkyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, alkylamino, acylamino, aminoalkyl, alkylsulfonyl, aminosulfonyl, -COOH, and acyl. R 4 is hydrogen or alkyl; L is -[C(R a R b )] p -; A 1 is Cyc 2 -Q-Cyc 3 ; R a and R b are each independently hydrogen or alkyl; p is 0 or 1; Cyc 2 is aryl or heteroaryl; Q is a bond; Cyc 3 is heteroaryl; M is a bond or -[C(R c R d )] t -[C(R e R f )] k -; A 2 is heterocycle or cycloalkyl; R c , R d , R e , and R f are each independently hydrogen, alkyl, hydroxyalkyl, or hydroxy; t is 0 or 1; and k is 0 or 1; wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently unsubstituted or substituted with substituents independently selected from halogen, =O (oxo), =S (thioxo), cyano, nitro, alkoxyfluoroalkyl, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, amino, alkylamino, acylamino, aminoalkyl, alkylsulfonyl, aminosulfonyl, -COOH, and acyl.
A laminate comprising: a recording layer ; a translucent front covering layer ; and a security foil having a thickness (T20) of 1/5 or less of a thickness (T11) of the recording layer laminated between the recording layer and the front covering layer , for sealing in the laminate , wherein the security foil includes a relief layer having a relief surface and a protective layer covering the relief surface , the protective layer adhering to the recording layer and the relief layer adhering to the front covering layer in a thickness direction of the laminate ; and an adhesion strength between the security foil and the recording layer is higher than an adhesion strength between the security foil and the front covering layer . a recording layer ; a translucent front covering layer ; and a security foil having a thickness (T20) of 1/5 or less of a thickness (T11) of the recording layer laminated between the recording layer and the front covering layer , for sealing in the laminate , wherein the security foil includes a relief layer having a relief surface and a protective layer covering the relief surface , the protective layer adhering to the recording layer and the relief layer adhering to the front covering layer in a thickness direction of the laminate ; and an adhesion strength between the security foil and the recording layer is higher than an adhesion strength between the security foil and the front covering layer .