mhurhangee/patent-ind-claim-en huggingface dataset:
A method of selecting a human subject, diagnosed with cancer whose cancer cells have non-overexpressed, non-amplified ErbB2 receptor, for treatment with a targeted therapeutic agent that affects an ErbB signaling pathway the method comprising: - preparing a sample of viable primary cancer cells obtained from the subject and culturing the sample in base media; - contacting a first portion of the sample of viable primary cancer cells obtained from the subject with a perturbing agent, and a second portion of the sample with a perturbing agent and a confirming agent, wherein the perturbing agent selectively affects the ErbB signaling pathway and the confirming agent selectively inhibits the effect of the perturbing agent on the same ErbB signaling pathway; - continuously measuring cell adhesion or attachment of the viable primary cancer cells in each portion of the sample; - determining by mathematical analysis of the continuous measurements of cell adhesion or attachment the reduction in cell adhesion or attachment between the first portion of the sample and the second portion of the sample; and - selecting the subject for treatment with the targeted therapeutic agent when the reduction is greater than 50%. - preparing a sample of viable primary cancer cells obtained from the subject and culturing the sample in base media; - contacting a first portion of the sample of viable primary cancer cells obtained from the subject with a perturbing agent, and a second portion of the sample with a perturbing agent and a confirming agent, wherein the perturbing agent selectively affects the ErbB signaling pathway and the confirming agent selectively inhibits the effect of the perturbing agent on the same ErbB signaling pathway; - continuously measuring cell adhesion or attachment of the viable primary cancer cells in each portion of the sample; - determining by mathematical analysis of the continuous measurements of cell adhesion or attachment the reduction in cell adhesion or attachment between the first portion of the sample and the second portion of the sample; and - selecting the subject for treatment with the targeted therapeutic agent when the reduction is greater than 50%.
A method for supporting a sorting process of workpieces , which are arranged on a sorting table and which have been produced with a processing plan using a flatbed machine tool, in particular a laser cutting or punching flatbed machine tool , comprising the steps: providing (step 51) a processing image data set of the processing plan underlying the arrangement of at least one workpiece ; imaging-based detecting (step 53) of the sorting table with a plurality of workpieces arranged spatially next to one another, and based thereon generating a first sorting image data set ; repeated imaging-based detecting (step 55) of the sorting table , and based thereon generating a second sorting image data set after at least one workpiece of the plurality of workpieces arranged spatially next to one another has been removed from the sorting table ; and comparing (step 57) of the first sorting image data set and the second sorting image data set including the processing image data set , wherein a sorting signal is generated containing an information including the type, the location, and/or the shape of the at least one removed workpiece . providing (step 51) a processing image data set of the processing plan underlying the arrangement of at least one workpiece ; imaging-based detecting (step 53) of the sorting table with a plurality of workpieces arranged spatially next to one another, and based thereon generating a first sorting image data set ; repeated imaging-based detecting (step 55) of the sorting table , and based thereon generating a second sorting image data set after at least one workpiece of the plurality of workpieces arranged spatially next to one another has been removed from the sorting table ; and comparing (step 57) of the first sorting image data set and the second sorting image data set including the processing image data set , wherein a sorting signal is generated containing an information including the type, the location, and/or the shape of the at least one removed workpiece .
A system for decoding received data sent from a transmitter to a receiver over an optical communications channel, comprising: a carrier phase estimator (CPE) to estimate a carrier phase of received symbols; a slip process analyzer to provide feedforward soft-decision information in a form of a slip state-transition matrix using a hidden Markov model (HMM) based on the carrier phase; a demodulator to calculate log-likelihood ratios (LLR) according to the feedforward soft-decision information; and a forward-error-correction (FEC) decoder to produce hard decision on symbols corresponding to the data, and to correct errors, characterised in that : the carrier phase estimator (CPE) comprising an amplitude normalizer adapted to suppress modulation-dependent amplitude deviation and scale the amplitude of IRI by a nonlinear function F(IRI) to provide F(IRI)RM, the nonlinear function being based on a conditional mean according to a following equation for Q-ary constellations as {S1,..., SQ} to minimize phase estimation errors, where R is received data, σ2 is a noise variance, and F R = 1 Q ∑ m = 1 Q e − j 4 ∠ S m R 8 S m 4 1 − e − 4 R S m / σ 2 R 2 S m 2 + 2 σ 4 − 2 R S m σ 2 R 2 S m 2 + 6 σ 4 − 6 R S m σ 2 − R 2 S m 2 + 2 σ 4 + 2 R S m σ 2 R 2 S m 2 + 6 σ 4 + 6 R S m σ 2 e − 4 R S m / σ 2 a carrier phase estimator (CPE) to estimate a carrier phase of received symbols; a slip process analyzer to provide feedforward soft-decision information in a form of a slip state-transition matrix using a hidden Markov model (HMM) based on the carrier phase; a demodulator to calculate log-likelihood ratios (LLR) according to the feedforward soft-decision information; and a forward-error-correction (FEC) decoder to produce hard decision on symbols corresponding to the data, and to correct errors, characterised in that : the carrier phase estimator (CPE) comprising an amplitude normalizer adapted to suppress modulation-dependent amplitude deviation and scale the amplitude of IRI by a nonlinear function F(IRI) to provide F(IRI)RM, the nonlinear function being based on a conditional mean according to a following equation for Q-ary constellations as {S1,..., SQ} to minimize phase estimation errors, where R is received data, σ2 is a noise variance, and F R = 1 Q ∑ m = 1 Q e − j 4 ∠ S m R 8 S m 4 1 − e − 4 R S m / σ 2 R 2 S m 2 + 2 σ 4 − 2 R S m σ 2 R 2 S m 2 + 6 σ 4 − 6 R S m σ 2 − R 2 S m 2 + 2 σ 4 + 2 R S m σ 2 R 2 S m 2 + 6 σ 4 + 6 R S m σ 2 e − 4 R S m / σ 2
A device for visually indicating a speed of a motor vehicle, the device comprising: an external surface of the motor vehicle; one or more thermochromic paint coating layers disposed on said external surface of the motor vehicle, wherein each of the one or more thermochromic paint coating layers is indicative of a color based on a variation in a temperature; one or more thermoelectric couple strips disposed underneath the corresponding one or more thermochromic paint coating layers and adapted to regulate the temperature of the corresponding one or more thermochromic paint coating layers; one or more temperature sensors for sensing an instantaneous temperature on the external surface of the motor vehicle; and a control unit configured to: receive an instantaneous speed of the motor vehicle from one or more odometry devices of the motor vehicle and the instantaneous temperature from the one or more temperature sensors; and configure the one or more thermoelectric couple strips to regulate temperatures of the one or more corresponding thermochromic paint coating layers, based on the instantaneous speed and the instantaneous temperature, to dynamically control indication of a color pattern associated with a range of instantaneous speed of the motor vehicle. an external surface of the motor vehicle; one or more thermochromic paint coating layers disposed on said external surface of the motor vehicle, wherein each of the one or more thermochromic paint coating layers is indicative of a color based on a variation in a temperature; one or more thermoelectric couple strips disposed underneath the corresponding one or more thermochromic paint coating layers and adapted to regulate the temperature of the corresponding one or more thermochromic paint coating layers; one or more temperature sensors for sensing an instantaneous temperature on the external surface of the motor vehicle; and a control unit configured to: receive an instantaneous speed of the motor vehicle from one or more odometry devices of the motor vehicle and the instantaneous temperature from the one or more temperature sensors; and configure the one or more thermoelectric couple strips to regulate temperatures of the one or more corresponding thermochromic paint coating layers, based on the instantaneous speed and the instantaneous temperature, to dynamically control indication of a color pattern associated with a range of instantaneous speed of the motor vehicle. receive an instantaneous speed of the motor vehicle from one or more odometry devices of the motor vehicle and the instantaneous temperature from the one or more temperature sensors; and configure the one or more thermoelectric couple strips to regulate temperatures of the one or more corresponding thermochromic paint coating layers, based on the instantaneous speed and the instantaneous temperature, to dynamically control indication of a color pattern associated with a range of instantaneous speed of the motor vehicle.
A print control device comprising print control means configured to control, when laying out and performing printing of a plurality of images on a single piece of printing paper, printing of cutting marks serving as an aid for cutting off the plurality of images from the printing paper, wherein the print control means is configured to switch, in accordance with a layout of the plurality of images, whether the cutting marks are to be printed using color inks, or to be printed by a changing pattern of overcoat using transparent ink, control such that in a case of a layout with margin areas for printing the cutting marks on the printing paper, the cutting marks are formed by the color inks, in a case of a layout with no margin areas for printing the cutting marks, the cutting marks are formed by the overcoat, and change the pattern of overcoat to be formed on the images, for each of areas on the printing paper, to form the cutting marks, in a case of a layout with no margin areas for printing the cutting marks on the printing paper. print control means configured to control, when laying out and performing printing of a plurality of images on a single piece of printing paper, printing of cutting marks serving as an aid for cutting off the plurality of images from the printing paper, wherein the print control means is configured to switch, in accordance with a layout of the plurality of images, whether the cutting marks are to be printed using color inks, or to be printed by a changing pattern of overcoat using transparent ink, control such that in a case of a layout with margin areas for printing the cutting marks on the printing paper, the cutting marks are formed by the color inks, in a case of a layout with no margin areas for printing the cutting marks, the cutting marks are formed by the overcoat, and in a case of a layout with margin areas for printing the cutting marks on the printing paper, the cutting marks are formed by the color inks, in a case of a layout with no margin areas for printing the cutting marks, the cutting marks are formed by the overcoat, and change the pattern of overcoat to be formed on the images, for each of areas on the printing paper, to form the cutting marks, in a case of a layout with no margin areas for printing the cutting marks on the printing paper.
High-current contact device for a motor vehicle or a charging station, - wherein the high-current contact device has at least one first contact element designed for transmission of electrical energy, a circuit carrier , at least one first data contact for transmission of a data signal and at least one data interface , - wherein the first contact element reaches through the circuit carrier along a mating axis at a feedthrough , - wherein a conductor track of the circuit carrier electrically connects the first data contact to the data interface , - wherein a carrier of the circuit carrier mechanically supports the first data contact , the conductor track and the data interface , - wherein the carrier has a first portion and a second portion connected to the first portion , - wherein the feedthrough is arranged in the first portion , - wherein the carrier is made in one piece and from the same electrically insulating material, characterized in that, - the high-current contact device comprises a second contact element , which is designed for transmission of electrical energy, - wherein the carrier of the circuit carrier is injection-moulded, - wherein the second portion is arranged offset to the first portion in relation to the mating axis , - wherein the second contact element is of a different design to the first contact element , and - wherein the data contact and the second contact element are arranged on the second portion . - wherein the high-current contact device has at least one first contact element designed for transmission of electrical energy, a circuit carrier , at least one first data contact for transmission of a data signal and at least one data interface , - wherein the first contact element reaches through the circuit carrier along a mating axis at a feedthrough , - wherein a conductor track of the circuit carrier electrically connects the first data contact to the data interface , - wherein a carrier of the circuit carrier mechanically supports the first data contact , the conductor track and the data interface , - wherein the carrier has a first portion and a second portion connected to the first portion , - wherein the feedthrough is arranged in the first portion , - wherein the carrier is made in one piece and from the same electrically insulating material, - the high-current contact device comprises a second contact element , which is designed for transmission of electrical energy, - wherein the carrier of the circuit carrier is injection-moulded, - wherein the second portion is arranged offset to the first portion in relation to the mating axis , - wherein the second contact element is of a different design to the first contact element , and - wherein the data contact and the second contact element are arranged on the second portion .
A service packet transmission method, wherein the method is applied to an Ethernet Ring Protection Switching, ERPS, network, wherein at least one ring protection instance is configured for each ERPS ring on the ERPS network, each ring protection instance comprises at least two ring protection sub-instances, each ring protection sub-instance respectively corresponds to one ring protection link, RPL, port, a status of the RPL port is a blocked state, and the method comprises: when receiving a service packet by an ordinary node device, determining, by the ordinary node device according to a preset rule and based on packet header information of the service packet, a ring protection sub-instance corresponding to the service packet, wherein the ordinary node device is a device that does not comprise the RPL port ; determining, by the ordinary node device based on a preset correspondence between the ring protection sub-instance and a forwarding path, the forwarding path used for forwarding the service packet (step 202); and forwarding, by the ordinary node device, the service packet based on the forwarding path . when receiving a service packet by an ordinary node device, determining, by the ordinary node device according to a preset rule and based on packet header information of the service packet, a ring protection sub-instance corresponding to the service packet, wherein the ordinary node device is a device that does not comprise the RPL port ; determining, by the ordinary node device based on a preset correspondence between the ring protection sub-instance and a forwarding path, the forwarding path used for forwarding the service packet (step 202); and forwarding, by the ordinary node device, the service packet based on the forwarding path .
A Compound of Formula I wherein (i) R 1 and R 2 together with the nitrogen atom form an azetidin-1-yl; (ii) R 3 is H or C 1-4 alkyl (e.g., methyl); (iii) R 4 is heteroaryl, halo (e.g. chloro), cyano or aryl (e.g., phenyl) optionally substituted with one or more groups selected from C 1-4 alkyl (e.g., methyl, ethyl, or propyl, e.g., isopropyl), C 3-7 cycloalkyl (e.g., cyclopropyl), C 1-4 alkoxy (e.g., methoxy) and haloC 1-4 alkyl (e.g., trifluoromethyl); (iv) R 5 is H or C 1-4 alkyl (e.g., methyl); (v) R 6 is H or C 1-4 alkyl (e.g., methyl). in free or salt form. (i) R 1 and R 2 together with the nitrogen atom form an azetidin-1-yl; (ii) R 3 is H or C 1-4 alkyl (e.g., methyl); (iii) R 4 is heteroaryl, halo (e.g. chloro), cyano or aryl (e.g., phenyl) optionally substituted with one or more groups selected from C 1-4 alkyl (e.g., methyl, ethyl, or propyl, e.g., isopropyl), C 3-7 cycloalkyl (e.g., cyclopropyl), C 1-4 alkoxy (e.g., methoxy) and haloC 1-4 alkyl (e.g., trifluoromethyl); (iv) R 5 is H or C 1-4 alkyl (e.g., methyl); (v) R 6 is H or C 1-4 alkyl (e.g., methyl).
A method for writing to a set of serial peripheral interface, SPI, slaves coupled to an SPI bus , the method comprising: sequentially writing to each SPI slave of a set of SPI slaves using a MOSI line of the SPI bus to disable master in slave out, MISO, drivers of the set of SPI slaves; after disabling the MISO drivers, setting respective slave selection terminals of the set of SPI slaves to an active state; and after setting the respective slave selection terminals of the set of SPI slaves to the active state, simultaneously writing data to the set of SPI slaves using a master out slave in, MOSI, line. sequentially writing to each SPI slave of a set of SPI slaves using a MOSI line of the SPI bus to disable master in slave out, MISO, drivers of the set of SPI slaves; after disabling the MISO drivers, setting respective slave selection terminals of the set of SPI slaves to an active state; and after setting the respective slave selection terminals of the set of SPI slaves to the active state, simultaneously writing data to the set of SPI slaves using a master out slave in, MOSI, line.
A system for perforating a formation intersected by a wellbore, comprising: a carrier ; and a plurality of shaped charges positioned along charge holder in the carrier; and the system characterised by : a plurality of pellets at least partially of a reactant composite material positioned in the charge holder and interleaved with plurality of shaped charges , the reactant composite material being oxygen overbalanced sufficient to react with a carbon released upon detonation of the plurality of shaped charges , the plurality of pellets being configured to disintegrate upon detonation of the shaped charges and release the oxygen; respective axial spaces separating adjacent shaped charges of the plurality of shaped charges from one another, each axial space including at least one pellet of the plurality of pellets ; and a detonator cord configured to detonate the plurality of shaped charges . a carrier ; and a plurality of shaped charges positioned along charge holder in the carrier; and the system characterised by : a plurality of pellets at least partially of a reactant composite material positioned in the charge holder and interleaved with plurality of shaped charges , the reactant composite material being oxygen overbalanced sufficient to react with a carbon released upon detonation of the plurality of shaped charges , the plurality of pellets being configured to disintegrate upon detonation of the shaped charges and release the oxygen; respective axial spaces separating adjacent shaped charges of the plurality of shaped charges from one another, each axial space including at least one pellet of the plurality of pellets ; and a detonator cord configured to detonate the plurality of shaped charges .
An ApoCIII specific inhibitor for use in a method of i) treating, preventing, delaying or ameliorating Lipoprotein lipase deficiency (LPLD) or Familial Chylomicronemia Syndrome (FCS) in an animal; or ii) preventing, delaying or ameliorating pancreatitis, or symptom thereof in an animal with LPLD or FCS, wherein the ApoCIII specific inhibitor comprises an antisense compound targeting ApoCIII, wherein the antisense compound is an interfering RNA compound.
An agent for removing stains or deposits from hard or soft surfaces, which agent comprises surfactants, an adhesion promoter and at least one active substance, where the surfactant fraction is between 10% by weight and 60% by weight, where the adhesion promoter is selected from the group of the alkylene styrene copolymers, where the alkylene styrene copolymers are selected from the group consisting of diblock or triblock copolymers and in particular from the group of the styrene-butadiene-styrene copolymers (SBS), the styrene-isoprene-styrene copolymer (SIS), the styrene-ethylene/butylene-styrene copolymers (S-EB-S), the styrene-ethylene/propylene copolymers (S-EP), the styrene-ethylene/butylene copolymers (S-EB), the styrene-butadiene copolymers (SB) and styrene-isoprene copolymers (SI), where the alkylene styrene copolymers may also be hydrogenated or partially hydrogenated and the active substance is an acid, an alkali, a bleach and/or hydrophobic organic solvent not bonded in a gel, and the agent comprises either at least 10% by weight of at least one acid or at least 10% by weight of at least one alkali and/or at least 5% by weight of a bleach, or comprises at least 10% by weight of hydrophobic organic solvent not bonded in a gel, whereby the viscosity of the agent with the hydrophobic organic solvent not bonded in a gel is at least 30 Pa*s measured using a Haake viscometer, plate/plate system, plate diameter 10 mm, with a shear gradient of 2.62 s-1 and 20°C or whereby the agent comprises at least 10% by weight of hydrophobic organic solvent not bonded in a gel and at least 2 % Alkali. where the surfactant fraction is between 10% by weight and 60% by weight, where the adhesion promoter is selected from the group of the alkylene styrene copolymers, where the alkylene styrene copolymers are selected from the group consisting of diblock or triblock copolymers and in particular from the group of the styrene-butadiene-styrene copolymers (SBS), the styrene-isoprene-styrene copolymer (SIS), the styrene-ethylene/butylene-styrene copolymers (S-EB-S), the styrene-ethylene/propylene copolymers (S-EP), the styrene-ethylene/butylene copolymers (S-EB), the styrene-butadiene copolymers (SB) and styrene-isoprene copolymers (SI), where the alkylene styrene copolymers may also be hydrogenated or partially hydrogenated and the active substance is an acid, an alkali, a bleach and/or hydrophobic organic solvent not bonded in a gel, and the agent comprises either at least 10% by weight of at least one acid or at least 10% by weight of at least one alkali and/or at least 5% by weight of a bleach, or comprises at least 10% by weight of hydrophobic organic solvent not bonded in a gel, whereby the viscosity of the agent with the hydrophobic organic solvent not bonded in a gel is at least 30 Pa*s measured using a Haake viscometer, plate/plate system, plate diameter 10 mm, with a shear gradient of 2.62 s-1 and 20°C or whereby the agent comprises at least 10% by weight of hydrophobic organic solvent not bonded in a gel and at least 2 % Alkali.