A high-resolution optical sensor device, having - multiple radiation sources (LED1-LED6) or a source with multiple wavelength ranges and - multiple radiation detectors (PD1-PD4) or a radiation detector having multiple separately readable sub-units to determine the amounts of target substances in highly scattering measurement objects, - a radiation barrier which is designed to absorb and/or reflect radiation of at least one wavelength range, wherein the radiation sources are arranged at different predetermined distances from the radiation detectors and are arranged separated from the radiation detectors by the radiation barrier in such a way that the radiations generated by the radiation sources first travel a path length through the measurement before impinging on the radiation detectors, and - an amplifier unit which is designed to amplify signals from the radiation detectors at the various predetermined distances in such a way that similar signal amplitudes are generated for all radiation detectors or with an area of the radiation detectors, wherein the area of the radiation detectors is respectively selected for a predetermined distance so that the signal amplitudes are similar for all predetermined distances, wherein one of the irradiated wavelengths or a wavelength range is suitable for having an effect on the sensor signals of the target substance to be determined, namely the amounts of radiation detected by the detector(s), and wherein at least one of the irradiated wavelengths or one of the irradiated wavelength ranges is suitable for having no effect on the sensor signals of the target substance to be determined, namely the amounts of radiation detected by the detector(s), wherein the target substance is one or more substances from the group of antioxidants, water, hemoglobin, oxidized hemoglobin, hematocrit, fat, protein, melanin, sunscreen and bilirubin, wherein at least one pair of effect-showing and no-effect-showing wavelengths of radiation can always be irradiated at the same distance d. - multiple radiation sources (LED1-LED6) or a source with multiple wavelength ranges and - multiple radiation detectors (PD1-PD4) or a radiation detector having multiple separately readable sub-units to determine the amounts of target substances in highly scattering measurement objects, - a radiation barrier which is designed to absorb and/or reflect radiation of at least one wavelength range, wherein the radiation sources are arranged at different predetermined distances from the radiation detectors and are arranged separated from the radiation detectors by the radiation barrier in such a way that the radiations generated by the radiation sources first travel a path length through the measurement before impinging on the radiation detectors, and - an amplifier unit which is designed to amplify signals from the radiation detectors at the various predetermined distances in such a way that similar signal amplitudes are generated for all radiation detectors or with an area of the radiation detectors, wherein the area of the radiation detectors is respectively selected for a predetermined distance so that the signal amplitudes are similar for all predetermined distances, wherein one of the irradiated wavelengths or a wavelength range is suitable for having an effect on the sensor signals of the target substance to be determined, namely the amounts of radiation detected by the detector(s), and <EOS>