mhurhangee/patent-ind-claim-en huggingface dataset:
A fluid dispenser for administering a fluid, comprising: a dispenser case ; a reservoir suitable for holding a plurality of doses of the fluid; a tube enclosed in the dispenser case , the tube having a first fold point , a second fold point , an inlet end and an outlet end , the inlet end being disposed in the reservoir, the outlet end being connected to an outlet orifice , wherein the tube is made from compliant materials, the tube is foldable along its length at each of the first and second fold points , the first fold point being a first articulating point, the second fold point being a second articulating point, the angle of the folds being operable to constrict the tube bore and thereby prevent fluid flow, and a segment of the tube between the first fold point and the second fold point is a squeezing section housing a dosing chamber ; and an actuating assembly, which when actuated presses against the squeezing section , causing a dose of a fluid housed in the dosing chamber to be dispensed. a dispenser case ; a reservoir suitable for holding a plurality of doses of the fluid; a tube enclosed in the dispenser case , the tube having a first fold point , a second fold point , an inlet end and an outlet end , the inlet end being disposed in the reservoir, the outlet end being connected to an outlet orifice , wherein the tube is made from compliant materials, the tube is foldable along its length at each of the first and second fold points , the first fold point being a first articulating point, the second fold point being a second articulating point, the angle of the folds being operable to constrict the tube bore and thereby prevent fluid flow, and a segment of the tube between the first fold point and the second fold point is a squeezing section housing a dosing chamber ; and wherein the tube is made from compliant materials, the tube is foldable along its length at each of the first and second fold points , the first fold point being a first articulating point, the second fold point being a second articulating point, the angle of the folds being operable to constrict the tube bore and thereby prevent fluid flow, and a segment of the tube between the first fold point and the second fold point is a squeezing section housing a dosing chamber ; and an actuating assembly, which when actuated presses against the squeezing section , causing a dose of a fluid housed in the dosing chamber to be dispensed.
An aerosol delivery device comprising: a mouthpiece end ; a primary air channel extending from an air inlet of the aerosol delivery device to an opening in the mouthpiece end ; an aerosol generation chamber in fluid communication with the mouthpiece end via a portion of the primary air channel , wherein the aerosol generation chamber comprises an aerosol source for generating an aerosol from a source material for inhalation by a user through the mouthpiece end during use; and a sensor for detecting when a user inhales on the mouthpiece end , wherein the sensor is in fluid communication with the mouthpiece end via a secondary air channel , and wherein the sensor is located further from the mouthpiece end than the aerosol source , and characterised in that the secondary air channel bypasses the aerosol generation chamber such that the secondary air channel is completely separate from the primary air channel , or is separate from the primary air channel up to a location in the primary air channel which is downstream of the aerosol generation chamber . a mouthpiece end ; a primary air channel extending from an air inlet of the aerosol delivery device to an opening in the mouthpiece end ; an aerosol generation chamber in fluid communication with the mouthpiece end via a portion of the primary air channel , wherein the aerosol generation chamber comprises an aerosol source for generating an aerosol from a source material for inhalation by a user through the mouthpiece end during use; and a sensor for detecting when a user inhales on the mouthpiece end , wherein the sensor is in fluid communication with the mouthpiece end via a secondary air channel , and wherein the sensor is located further from the mouthpiece end than the aerosol source , and characterised in that the secondary air channel bypasses the aerosol generation chamber such that the secondary air channel is completely separate from the primary air channel , or is separate from the primary air channel up to a location in the primary air channel which is downstream of the aerosol generation chamber .
A method for preparing a glycoprotein-toxic payload molecule conjugate represented by formula I [D-L-G] n -Gp Formula I wherein Gp is a glycoprotein comprising an N-glycan, wherein the N-glycan comprises a GlcNAc residue bound by a β-N linkage to an asparagine; n is an integer from 1 to 20; D is a toxic payload molecule; L is a linker group covalently joining G to D; and G is a saccharide structure represented by formula II wherein R is a glycosidic bond to the GlcNAc residue bound by a β-N linkage to an asparagine; X 1 is H; X 2 is a bond to L and X 3 and X 4 are each OH; X 5 is CH 2 OH; wherein the method comprises the steps of: providing a glycoprotein comprising an N-glycan comprising an acceptor site, wherein the glycoprotein comprising the N-glycan comprising the acceptor site is prepared by contacting a glycoprotein comprising an N-glycan with an endoglycosidase, wherein the N-glycan is a hybrid-type N-glycan and the endoglycosidase is EndoS2; and reacting a donor molecule with the glycoprotein comprising the N-glycan comprising the acceptor site in the presence of a glycosyltransferase, wherein the glycosyltransferase is human β1,4-GalT1(Y285L) or bovine β1,4-GalT1(Y289L); wherein the donor molecule is UDP-2-(2-azidoacetamido)-2-deoxy-Gal (UDP-GalNAz). Gp is a glycoprotein comprising an N-glycan, wherein the N-glycan comprises a GlcNAc residue bound by a β-N linkage to an asparagine; n is an integer from 1 to 20; D is a toxic payload molecule; L is a linker group covalently joining G to D; and G is a saccharide structure represented by formula II R is a glycosidic bond to the GlcNAc residue bound by a β-N linkage to an asparagine; X 1 is H; X 2 is a bond to L and X 3 and X 4 are each OH; X 5 is CH 2 OH; wherein the method comprises the steps of: providing a glycoprotein comprising an N-glycan comprising an acceptor site, wherein the glycoprotein comprising the N-glycan comprising the acceptor site is prepared by contacting a glycoprotein comprising an N-glycan with an endoglycosidase, wherein the N-glycan is a hybrid-type N-glycan and the endoglycosidase is EndoS2; and reacting a donor molecule with the glycoprotein comprising the N-glycan comprising the acceptor site in the presence of a glycosyltransferase, wherein the glycosyltransferase is human β1,4-GalT1(Y285L) or bovine β1,4-GalT1(Y289L); wherein the donor molecule is UDP-2-(2-azidoacetamido)-2-deoxy-Gal (UDP-GalNAz). providing a glycoprotein comprising an N-glycan comprising an acceptor site, wherein the glycoprotein comprising the N-glycan comprising the acceptor site is prepared by contacting a glycoprotein comprising an N-glycan with an endoglycosidase, wherein the N-glycan is a hybrid-type N-glycan and the endoglycosidase is EndoS2; and reacting a donor molecule with the glycoprotein comprising the N-glycan comprising the acceptor site in the presence of a glycosyltransferase, wherein the glycosyltransferase is human β1,4-GalT1(Y285L) or bovine β1,4-GalT1(Y289L); wherein the donor molecule is UDP-2-(2-azidoacetamido)-2-deoxy-Gal (UDP-GalNAz).
A pharmaceutical composition comprising naltrexone for use in the treatment of a subject having a tumour/cancer selected from: breast cancer, cervical squamous cell carcinoma, gastric carcinoma, glioma, hepatocellular carcinoma, lung cancer, melanoma, recurrent glioblastoma and colorectal cancer, wherein the naltrexone, as part of said composition, is to be administered to the subject by oral administration at a dose between 0.01 mg/kg and 0.08 mg/kg, wherein the subject is tested for TLR9 overexpression and/or overactivity of TLR9-mediated signalling and the tumour/cancer is characterised as having TLR9 overexpression and/or overactivity of TLR9-mediated signalling and wherein the subject is to be administered at least one chemotherapeutic agent.
An inhibitory designer receptor exclusively activated by a designer drug (DREADD) and an excitatory DREADD for use in the treatment of a neuronal hypo-kinetic disease or disorder, wherein said inhibitory DREADD is expressed in the internal globus pallidus (GPi); and said excitatory DREADD is expressed in: the anterior motor thalamus, the external globus pallidum (GPe), the subthalamic nucleus (STN), or any combination thereof, and wherein said expressed inhibitory DREADD and said excitatory DREADD are activated by a single ligand.
Process for production of an organized network of nanowires on metallic substrate, said process comprising the following steps: a) providing a metallic substrate; b) anodizing said metallic substrate so as to form an oxide layer on said metallic substrate; c) etching the oxide layer which has been formed in step (b) so as to form a template; d) depositing a component in the template formed in step (c), said component forming said nanowires; e) etching the residual amount of component; and f) etching partially the oxide layer so as to remove partially said template; wherein said nanowires are embedded in said oxide layer. a) providing a metallic substrate; b) anodizing said metallic substrate so as to form an oxide layer on said metallic substrate; c) etching the oxide layer which has been formed in step (b) so as to form a template; d) depositing a component in the template formed in step (c), said component forming said nanowires; e) etching the residual amount of component; and f) etching partially the oxide layer so as to remove partially said template;
A power and/or telecommunications cable comprising at least one elongate conductive element and at least one electrically insulating layer surrounding said elongate conductive element, characterized in that : - the electrically insulating layer comprises an organic polymer matrix in which there is dispersed a flame-retardant filler comprising a silicon oxide macromolecular network functionalized by phosphonate functions; and - the electrically insulating layer is obtained from a composition comprising at least one thermoplastic organic polymer and at least one precursor of said flame-retardant filler comprising silicon and phosphorus. - the electrically insulating layer comprises an organic polymer matrix in which there is dispersed a flame-retardant filler comprising a silicon oxide macromolecular network functionalized by phosphonate functions; and - the electrically insulating layer is obtained from a composition comprising at least one thermoplastic organic polymer and at least one precursor of said flame-retardant filler comprising silicon and phosphorus.
A modular decorative element (1; 2; 3; 6) obtained by cutting a sheet and comprising at least one flat portion (14; 27) having a substantially rhomboidal shape, said flat portion (14; 27) having a folding line (15; 28) and a first (16; 29) and a second (17; 30) hole, each hole (16, 17; 29, 30) being arranged at a respective end of said folding line (15; 28), said modular decorative element (1; 2; 3; 6) being configured in such a way that, during use, said at least one flat portion (14; 27) is folded along the respective folding line (15; 28) and coupled at said holes (16, 17; 29, 30) to one or more further decorative elements (1; 2; 3; 6; 7) in order to form an assembly (10; 31; 32) of decorative elements (1; 2; 3; 6; 7), said decorative element (1; 2; 3; 6)being characterised in that it comprises two or more of said flat portions (14; 27) having a substantially rhomboidal shape, integral with each other, wherein the folding line of each of said two or more of said flat portions (14; 27) is arranged along the major diagonal line, wherein one or each of said two or more flat portions (14; 27) has in common with one or more of the other flat portions (14; 27) the respective first hole (16; 29) or the respective second hole or its first hole with the second hole of the other flat portion .
A screen printer comprising: a board positioning device configured to convey and hold a board to a work position in the screen printer ; a mask holding device configured to hold a mask above the work position; a squeegee device configured to spread a cream solder through the mask on the board ; a correction device configured to correct a relative position between the board held by the board positioning device and the mask held by the mask holding device ; a control device configured to acquire inspection data of a print pattern of the board from a print inspection device provided inside or outside the screen printer and perform correction control on the correction device by a correction value corrected according to a deviation amount of printing based on the inspection data; and an input device configured to include an instruction input section that senses an inspection instruction operation of an operator and transmit, to the control device , an inspection data acquisition signal for acquiring the inspection data of the print pattern from the print inspection device based on an instruction operation of the operator to the instruction input section . a board positioning device configured to convey and hold a board to a work position in the screen printer ; a mask holding device configured to hold a mask above the work position; a squeegee device configured to spread a cream solder through the mask on the board ; a correction device configured to correct a relative position between the board held by the board positioning device and the mask held by the mask holding device ; a control device configured to acquire inspection data of a print pattern of the board from a print inspection device provided inside or outside the screen printer and perform correction control on the correction device by a correction value corrected according to a deviation amount of printing based on the inspection data; and an input device configured to include an instruction input section that senses an inspection instruction operation of an operator and transmit, to the control device , an inspection data acquisition signal for acquiring the inspection data of the print pattern from the print inspection device based on an instruction operation of the operator to the instruction input section .
A press fabric for a pulp machine having a multilayer structure obtained by weaving warps, each of which is selected from a group consisting of a monofilament, a monofilament twisted yarn, and a twisted yarn having a monofilament as a core, with, as wefts, firstly monofilaments and secondly yarns obtained by bundling raw yarns of a small diameter and forming a fine water-sucking space therebetween, wherein at least upper surface side wefts and lower surface side wefts are arranged vertically as the wefts, characterized in that two adjacent weft monofilaments are alternately arranged with either one of: a weft yarn forming a fine water-sucking space; and two adjacent weft yarns forming a fine water-sucking space, as the lower surface side wefts.
A device for removal /installation of main rotor blades from/to a rotor hub of a rotorcraft, comprising a clamp body having a clamp opening , in which a rotor blade may be disposed, an extension opening and a traverse block having an internally threaded portion ; a reaction plate having a recess in a first face at a first side of the reaction plate and one or more pins disposed in the recess extending away from the first face , and further having an extension extending along a long axis of the reaction plate through the extension opening ; and bearing blocks disposed on a second side of the reaction plate opposite the first side, wherein the traverse block is disposed between the bearing blocks ; an actuator aligned parallel to the long axis of the reaction plate and extending through each of the bearing blocks and through the traverse block , wherein the actuator has an externally threaded portion engaged with the internally threaded portion of the traverse block .
A patient interface system to treat sleep disordered breathing of a patient with pressurized gas, comprising: a patient interface including: a plenum chamber configured to be pressurised above atmospheric pressure in use by the pressurized gas; and a seal-forming structure connected to the plenum chamber and structured to seal against the patient's face around the nose and/or mouth to direct the pressurized gas into the patient's airways during use; and a positioning and stabilising structure configured to hold the seal-forming structure in a sealing position against the patient's face, the positioning and stabilising structure including: at least one strap ; at least one cushion formed from a soft, flexible composite material and structured to at least partially conform to the patient's head; and at least one retractor fixedly attached to said at least one cushion, said at least one retractor connected to the at least one strap and configured to retract the at least one strap without patient actuation to urge the patient interface into the sealing position against the patient's face during use, wherein the at least one strap joins the at least one retractor to the patient interface. a patient interface including: a plenum chamber configured to be pressurised above atmospheric pressure in use by the pressurized gas; and a seal-forming structure connected to the plenum chamber and structured to seal against the patient's face around the nose and/or mouth to direct the pressurized gas into the patient's airways during use; and a plenum chamber configured to be pressurised above atmospheric pressure in use by the pressurized gas; and a seal-forming structure connected to the plenum chamber and structured to seal against the patient's face around the nose and/or mouth to direct the pressurized gas into the patient's airways during use; and a positioning and stabilising structure configured to hold the seal-forming structure in a sealing position against the patient's face, the positioning and stabilising structure including: at least one strap ; at least one cushion formed from a soft, flexible composite material and structured to at least partially conform to the patient's head; and at least one retractor fixedly attached to said at least one cushion, said at least one retractor connected to the at least one strap and configured to retract the at least one strap without patient actuation to urge the patient interface into the sealing position against the patient's face during use, at least one strap ; at least one cushion formed from a soft, flexible composite material and structured to at least partially conform to the patient's head; and at least one retractor fixedly attached to said at least one cushion, said at least one retractor connected to the at least one strap and configured to retract the at least one strap without patient actuation to urge the patient interface into the sealing position against the patient's face during use, wherein the at least one strap joins the at least one retractor to the patient interface.
A method for determining an amount of paper product dispensed from a dispenser or remaining in the dispenser , wherein the paper product is initially loaded in the dispenser as a paper product formation (14; 80), the method comprising: at defined intervals, taking a digital image of an aspect of the paper product formation (14; 80) in the dispenser , and transmitting the digital image to a digital image processor ; with the digital image processor , analyzing a feature of the digital image that changes as the paper product formation (14; 80) decreases in size as the paper product is dispensed; comparing the analyzed feature with a predetermined value of the feature at a predefined size of the paper product formation (14; 80) to determine an amount of the paper product dispensed or remaining in the dispenser ; and characterised in that the analyzed feature is a dimension or pixel count of a mark on the side of the paper product formation (14; 80) and the digital image is taken of the side of the paper product formation (14; 80), the mark having a color that contrasts with the paper product and a pattern or design that decreases in size as the paper product is dispensed, wherein a decreasing pixel count or dimension is a measure of the amount of product dispensed, and the digital image processor compares the dimension or pixel count of the mark with a known dimension or total count of the pixels corresponding to the mark at a predefined size of the paper product formation (14; 80). at defined intervals, taking a digital image of an aspect of the paper product formation (14; 80) in the dispenser , and transmitting the digital image to a digital image processor ; with the digital image processor , analyzing a feature of the digital image that changes as the paper product formation (14; 80) decreases in size as the paper product is dispensed; comparing the analyzed feature with a predetermined value of the feature at a predefined size of the paper product formation (14; 80) to determine an amount of the paper product dispensed or remaining in the dispenser ; and characterised in that the analyzed feature is a dimension or pixel count of a mark on the side of the paper product formation (14; 80) and the digital image is taken of the side of the paper product formation (14; 80), the mark having a color that contrasts with the paper product and a pattern or design that decreases in size as the paper product is dispensed, wherein a decreasing pixel count or dimension is a measure of the amount of product dispensed, and the digital image processor compares the dimension or pixel count of the mark with a known dimension or total count of the pixels corresponding to the mark at a predefined size of the paper product formation (14; 80).
A battery tray , comprising a tray body, wherein the tray body comprises a base plate , a side beam , and several partition plates , the side beam is disposed around the base plate and defines, together with the base plate , an accommodating space for battery cells , the partition plates are disposed on the base plate and divide the base plate into several regions for placing the battery cells ; and the partition plates and the side beam are each formed therein with an air passage and are in communication with each other, the partition plates are provided with several inlet vents , the side beam is provided with at least one exhaust vent, the inlet vent is configured to introduce a flame, smoke or gas discharged from the battery cell into the air passage, and the exhaust vent is configured to discharge the flame, smoke or gas inside the air passage.