mhurhangee/patent-ind-claim-en huggingface dataset:
A dopamine stabilizing agent and an anti-depressive agent for use in the treatment of one or more symptoms of a disorder characterized by debilitating fatigue; wherein said dopamine stabilizing agent is -3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine or a pharmaceutically acceptable salt thereof; wherein said anti-depressive agent is selected from the group consisting of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRls); and wherein said disorder is selected from the group consisting of myalgic encephalomyelitis/chronic fatigue syndrome, fibromyalgia, mental fatigue, post stroke fatigue, Huntington's disease, Parkinson's disease, multiple sclerosis, narcolepsy, post cancer fatigue, fatigue associated with cancer with or without cytostatic treatment, depression, and combinations thereof; and wherein said one or more symptoms are selected from the group consisting of persistent and/or recurrent debilitating fatigue, diffuse musculoskeletal pain, sleep disturbances, neuropsychiatric symptoms, hopelessness, irritability and sadness. wherein said dopamine stabilizing agent is -3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine or a pharmaceutically acceptable salt thereof; wherein said anti-depressive agent is selected from the group consisting of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRls); and wherein said disorder is selected from the group consisting of myalgic encephalomyelitis/chronic fatigue syndrome, fibromyalgia, mental fatigue, post stroke fatigue, Huntington's disease, Parkinson's disease, multiple sclerosis, narcolepsy, post cancer fatigue, fatigue associated with cancer with or without cytostatic treatment, depression, and combinations thereof; and wherein said one or more symptoms are selected from the group consisting of persistent and/or recurrent debilitating fatigue, diffuse musculoskeletal pain, sleep disturbances, neuropsychiatric symptoms, hopelessness, irritability and sadness.
A method for limiting a communication range between transceivers for a vehicle based keyless entry system, the method comprising: transmitting, by a first transceiver , communicatively coupled to a controller , first radio frequency signals at a first transmission level corresponding to a first transmission range; attenuating, by the controller , the first radio frequency signals at a second transmission level lower than the first transmission level and that corresponds to a shorter transmission range than the first transmission range; detecting, by the controller , using the first radio frequency signals transmitted at the second transmission level, a presence of at least one second transceiver within the shorter transmission range; and responsive to the first transceiver receiving, from the at least one second transceiver, second radio frequency signals at a first reception level corresponding to a first reception range, limiting, by the controller , with respect to the first transceiver , a communication range of the at least one second transceiver to a second reception range that is shorter than the first reception range by attenuating the second radio frequency signals to a second reception level corresponding to the second reception range. transmitting, by a first transceiver , communicatively coupled to a controller , first radio frequency signals at a first transmission level corresponding to a first transmission range; attenuating, by the controller , the first radio frequency signals at a second transmission level lower than the first transmission level and that corresponds to a shorter transmission range than the first transmission range; detecting, by the controller , using the first radio frequency signals transmitted at the second transmission level, a presence of at least one second transceiver within the shorter transmission range; and responsive to the first transceiver receiving, from the at least one second transceiver, second radio frequency signals at a first reception level corresponding to a first reception range, limiting, by the controller , with respect to the first transceiver , a communication range of the at least one second transceiver to a second reception range that is shorter than the first reception range by attenuating the second radio frequency signals to a second reception level corresponding to the second reception range.
A sensor device for determining an axial position of a body along a longitudinal axis (A), the sensor device comprising: at least one excitation coil that extends around the longitudinal axis (A); at least one first detection coil arranged in the vicinity of the excitation coil essentially in a first detection plane (P1) perpendicular to the longitudinal axis (A); at least one second detection coil arranged in the vicinity of the excitation coil essentially in a second detection plane (P2) perpendicular to the longitudinal axis (A); excitation circuitry configured to supply the excitation coil with current at an excitation frequency to create an excitation magnetic field distribution; and detection circuitry configured to determine the axial position of the body based on signals from the first and second detection coils at the excitation frequency, characterized in that the second detection plane is arranged at an axial distance to the first detection plane, and that the detection circuitry is configured to base the determination of the axial position on at least one difference between the signals from the at least one first detection coil and the signals from the at least one second detection coil . at least one excitation coil that extends around the longitudinal axis (A); at least one first detection coil arranged in the vicinity of the excitation coil essentially in a first detection plane (P1) perpendicular to the longitudinal axis (A); at least one second detection coil arranged in the vicinity of the excitation coil essentially in a second detection plane (P2) perpendicular to the longitudinal axis (A); excitation circuitry configured to supply the excitation coil with current at an excitation frequency to create an excitation magnetic field distribution; and detection circuitry configured to determine the axial position of the body based on signals from the first and second detection coils at the excitation frequency, characterized in that the second detection plane is arranged at an axial distance to the first detection plane, and that the detection circuitry is configured to base the determination of the axial position on at least one difference between the signals from the at least one first detection coil and the signals from the at least one second detection coil .
A hearing aid device comprising means for being at least partly inserted into the ear canal of a hearing aid user , at least one electro-active member (4, 22, 32, 40, 46, 70, 70', 76, 76', 76") comprising a top electrode layer , a bottom electrode layer and a dielectric elastomer member sandwiched between the top electrode layer and the bottom electrode layer characterised in that the hearing aid device comprises a microphone inlet that is movably mounted by means of the at least one electro-active member (4, 22, 32, 40, 46, 70, 70', 76, 76', 76")..
A holder for receiving and fixing a cutting insert , wherein the holder comprises an insertion hole at a front end part of the holder to secure the insert; said front end part comprises a first curved surface part that becomes wider from a front end toward a back side when viewed from a side thereof; the first curved surface part comprises at least one of i) a curved line that extends from an edge of an opening of the insertion hole toward the back side; and ii) a straight line that extends from the edge of the opening of the insertion hole and connects to a curved line that extends continuously from the straight line toward the back side without an angular part , the holder being characterized in that coolant holes are formed at two or more positions on one side with respect to the opening of the insertion hole , and a ratio rd/(ri + rs) is 0.8 to 1.2, where rd is a distance between centers of two coolant holes that are the furthest apart from each other among the at least two coolant holes , ri is a diameter of the opening of the insertion hole , and rs is a diameter of the openings of the coolant holes . i) a curved line that extends from an edge of an opening of the insertion hole toward the back side; and ii) a straight line that extends from the edge of the opening of the insertion hole and connects to a curved line that extends continuously from the straight line toward the back side without an angular part , the holder being characterized in that coolant holes are formed at two or more positions on one side with respect to the opening of the insertion hole , and
A fastening system for fastening a rivet element to a workpiece, in particular to a sheet metal part , wherein the workpiece has a pre-shaped hole provided for the reception of a rivet section of the rivet element , wherein the workpiece is made planar at least in a region around the pre-shaped hole , wherein the fastening system includes a die which has at least one spacer which is fixedly connected to the die during the fastening process in order to position the workpiece at a well-defined spacing (D) from a contact surface of the die during the fastening process, so that a gap is formed between a wall of the hole and a punch of the die , which is provided for the reshaping of the rivet section , wherein the fastening system furthermore includes a setting head for introducing the rivet element into the workpiece , said rivet element being at least partly receivable in the setting head , characterized in that the spacer can be adjusted with respect to its position.
Mixing pot comprising a mixing mechanism which is arranged on a wall of the mixing pot and has a mounting body which is associated with the wall in a rotationally fixed manner for mounting a mixing shaft for rotating a mixing body , having in particular a set of blades, for forming a circulation flow of a liquid located in the mixing pot , a surface of the mounting body being provided which is in contact with the liquid and is designed as a truncated cone lateral surface, characterised in that the surface has a surface structure which disturbs the formation of a laminar boundary layer, for which purpose the surface structure has a plurality of surface structure elements on the otherwise smooth surface which are arranged so as to be spaced apart from one another in the flow direction and which are in the form of ribs or grooves , which extend in the direction of lateral surface lines of the truncated cone lateral surface, or in the form of indentations or bulges having a height of 1 mm to 3 mm, which transition into the truncated cone lateral surface without kinks, in a rounded manner or so as to form an edge.
A solar module , comprising: an encapsulating layer including a first surface and a second surface opposite to the first surface ; and a plurality of solar cells embedded in the encapsulating layer , a patterned layer is formed on the first surface of the encapsulating layer and includes at least one patterned unit having a plurality of color spots separated from one another, characterized in that a first translucent sheet is combined to the first surface of the encapsulating layer and the patterned layer , the first translucent sheet includes a light-facing surface and a backlit surface opposing the light-facing surface , and the first translucent sheet is joined with the encapsulating layer and the patterned layer through the backlit surface , the backlit surface is formed with a rough face and is joined with the encapsulating layer and the patterned layer through the rough face, and each of the color spots is between 0.03 mm and 0.10 mm in width. an encapsulating layer including a first surface and a second surface opposite to the first surface ; and a plurality of solar cells embedded in the encapsulating layer , a patterned layer is formed on the first surface of the encapsulating layer and includes at least one patterned unit having a plurality of color spots separated from one another, characterized in that a first translucent sheet is combined to the first surface of the encapsulating layer and the patterned layer , the first translucent sheet includes a light-facing surface and a backlit surface opposing the light-facing surface , and the first translucent sheet is joined with the encapsulating layer and the patterned layer through the backlit surface , the backlit surface is formed with a rough face and is joined with the encapsulating layer and the patterned layer through the rough face, and each of the color spots is between 0.03 mm and 0.10 mm in width.
Lying support with a lying surface, comprising a frame with parallel longitudinal frame parts, thereto-connected transverse frame parts and a floor element, whereby the frame comprises an inner area into which insert elements are receivable, whereby the insert elements have distinguishable hardness, as well as slots , and ventilation channels running transversely to the longitudinal direction, which are aligned with through holes formed in the parallel longitudinal frame parts, and which, by means of the slots , are connected to an outer side of the insert elements , whereby the inner area is divided into at least three zones , whereby in each zone at least two insert elements , lying over one another, are receivable, which differ with respect to their hardness, whereby the differing hardness of the insert elements lying over one another is produced through the orientation of the slots .
A soil working tool for an agricultural machine with a wear guard against over-wear in the form of at least two wear-resistant plates wherein at least one wear-resistant plate is shaped and adapted to be mounted in such a way that its profile, in the direction of movement of the soil working tool , covers, while in contact with the soil, the front edge of the next arranged wear-resistant plate , characterised in that said next arranged wear resistant plate is attached by a layer of adhesive, and the first wear-resistant plate arranged on top of the soil working tool is fastened by brazing.
A mask assembly comprising a mask seal, a mask base, and a mask seal adjustment mechanism coupled to the mask base, the mask seal adjustment mechanism configured to adjust the lateral distance between opposite walls of the mask seal by providing and controlling a lateral force to compress the mask seal primarily in a lateral direction across a width of the mask assembly, wherein the mask seal adjustment mechanism comprises a dial, and wherein the lateral force to compress the mask seal in the lateral direction is controlled by rotating the dial.
A catalyst composition comprising: catalyst component A comprising a bridged metallocene compound with two indenyl groups each indenyl being independently substituted with one or more substituents, wherein at least one of the substituent is an aryl or heteroaryl; wherein the aryl or heteroaryl substituent is on the 3-position on each indenyl; catalyst component B comprising a bridged metallocene compound with a substituted or unsubstituted cyclopentadienyl group and a substituted or unsubstituted fluorenyl group; an optional activator; an optional support; and an optional co-catalyst. catalyst component A comprising a bridged metallocene compound with two indenyl groups each indenyl being independently substituted with one or more substituents, wherein at least one of the substituent is an aryl or heteroaryl; wherein the aryl or heteroaryl substituent is on the 3-position on each indenyl; catalyst component B comprising a bridged metallocene compound with a substituted or unsubstituted cyclopentadienyl group and a substituted or unsubstituted fluorenyl group; an optional activator; an optional support; and an optional co-catalyst.
Method for the mass production of a marking applied to a first main surface of an object with a multicolored print of at least two or more paint droplets , each of which is of a different color and which at least partially flow into each other in an arbitrary manner and which are also partially blended together and distributed by an air nozzle , characterized by the following method steps: - providing the object having at least one main surface , - applying at least two paint droplets onto at least one of the main surfaces in a supersaturated manner, - distributing the at least two paint droplets by means of an air nozzle as long as they have not yet dried, - drying the distributed print, - abundantly repeating the aforementioned method steps for further objects . - providing the object having at least one main surface , - applying at least two paint droplets onto at least one of the main surfaces in a supersaturated manner, - distributing the at least two paint droplets by means of an air nozzle as long as they have not yet dried, - drying the distributed print, - abundantly repeating the aforementioned method steps for further objects .
A filter assembly for a floor cleaner for cleaning a floor surface, comprising: a filter having an intake side and an exhaust side ; a filter housing comprising a frame having an open area through which air may pass, the filter supported within the frame; a handle projecting from the filter housing; characterised by a mesh screen on the intake side of the filter, the mesh screen having a pore size configured to filter a larger particle size than the filter; a door pivotally coupled with the filter housing, the door having an open grid and the mesh screen covering the open grid; a seal on the filter housing, the seal extending around the exhaust side of the filter; and a permanent magnet disposed on the handle. a filter having an intake side and an exhaust side ; a filter housing comprising a frame having an open area through which air may pass, the filter supported within the frame; a handle projecting from the filter housing; characterised by a mesh screen on the intake side of the filter, the mesh screen having a pore size configured to filter a larger particle size than the filter; a door pivotally coupled with the filter housing, the door having an open grid and the mesh screen covering the open grid; a seal on the filter housing, the seal extending around the exhaust side of the filter; and a permanent magnet disposed on the handle.
An isolated or purified antisense oligonucleotide targeted to a nucleic acid molecule encoding vascular endothelial growth factor A (VEGF-A) pre-mRNA, wherein the antisense oligonucleotide has the nucleobase sequence SEQ ID NO: 4 which has a modified backbone structure and sequences with at least 95% sequence identity to SEQ ID NO: 4 which has a modified backbone structure, and wherein the antisense oligonucleotide inhibits the expression of human VEGF-A.
A mass spectrometry method for qualitative and quantitative analysis of peptidome in serum based on amino acid sequencing with a tandem mass spectrometry (MS) tool with signaling intensities measurement of peptides, characterized in that the method comprises the following steps: a) enrichment of peptides in the analyzed serum sample by incubation of a sample with a citrate-phosphate buffer with pH 3.1-3.6 in water with a purity ≥ 99.9%, wherein the buffer and serum volume ratio is 29:1 and the buffer and serum are mixed at a temperature of range 4 to 8°C to dissociate peptides from highly concentrated serum proteins; b) removing of proteins equal or bigger than 15 kDa from peptide enriched and simultaneously purification of peptides using hydrophilic-lipophilic balanced columns to obtain peptides smaller than 15 kDa; c) washing the hydrophilic-lipophilic balanced columns with high-grade water purity ≥ 99.9% with 0.2% formic acid (v/v) in order to remove the unbound and low-binding peptides from the columns; d) eluting of serum peptides bound to the hydrophilic-lipophilic balanced columns by using water / 80% methanol / 0.2% formic acid (v/v); e) filtrating of the sample through 3 kDa molecular weight filters to collect peptides smaller than 3 kDa; f) providing lyophilization of the obtained peptides by drying the eluted peptides through lyophilization for tandem mass spectrometry analysis, and then sequencing the isolated peptides based on amino acid sequences with a tandem mass spectrometry followed by intensities signaling measurement in studied serum sample in comparison with the matched control serum samples. a) enrichment of peptides in the analyzed serum sample by incubation of a sample with a citrate-phosphate buffer with pH 3.1-3.6 in water with a purity ≥ 99.9%, wherein the buffer and serum volume ratio is 29:1 and the buffer and serum are mixed at a temperature of range 4 to 8°C to dissociate peptides from highly concentrated serum proteins; b) removing of proteins equal or bigger than 15 kDa from peptide enriched and simultaneously purification of peptides using hydrophilic-lipophilic balanced columns to obtain peptides smaller than 15 kDa; c) washing the hydrophilic-lipophilic balanced columns with high-grade water purity ≥ 99.9% with 0.2% formic acid (v/v) in order to remove the unbound and low-binding peptides from the columns; d) eluting of serum peptides bound to the hydrophilic-lipophilic balanced columns by using water / 80% methanol / 0.2% formic acid (v/v); e) filtrating of the sample through 3 kDa molecular weight filters to collect peptides smaller than 3 kDa; f) providing lyophilization of the obtained peptides by drying the eluted peptides through lyophilization for tandem mass spectrometry analysis, and then sequencing the isolated peptides based on amino acid sequences with a tandem mass spectrometry followed by intensities signaling measurement in studied serum sample in comparison with the matched control serum samples.
A composition comprising a compound having the structure: where m and n are the same or different and are integers between 1 and 4; X is H or CH 3 ; R 1 is H amidino, a glycosylated serine or threonine residue, or one or more arginine residues, R 2 is H or methyl, R 3 is H or methyl, R 4 is H or a β or α sugar, R 5 is H or methyl, R 6 is CH 3 , OH, or O- β or α sugar, R 7 is H, a glycosylated serine or threonine residue, or one or more arginine residues.
A process for preparing alkanolamines and/or ethyleneamines in the liquid phase, by reacting ethylene glycol and/or monoethanolamine with ammonia in the presence of an amination catalyst which is obtained by reducing a catalyst precursor, wherein the preparation of the catalyst precursor comprises a step a) in which a catalyst precursor comprising one or more catalytically active components of Sn, Cu and Ni is first prepared and the catalyst precursor prepared in step a) is contacted simultaneously or successively with a soluble Ru compound and a soluble Co compound in a step b), and wherein the catalyst precursor which is prepared in step a) additionally comprises catalytically active components of Co.