mhurhangee/patent-ind-claim-en huggingface dataset:
A compound of formula I, I-1 or 1-2 wherein R 1 is hydrogen, C 1-7 -alkyl, C 1-7 -alkyl substituted by halogen, halogen, C 1-7 -alkoxy, or C 1-7 -alkoxy substituted by halogen; R 1 may be different if n = 2 or 3 n is 1, 2 or 3 Ar is a six membered heteroaryl group, selected from wherein R 2 is hydrogen, C 1-7 -alkyl, C 1-7 -alkyl substituted by halogen, halogen or C 1-7 -alkoxy; R 3 is hydrogen or halogen; or a pharmaceutically active acid addition salt thereof. R 1 is hydrogen, C 1-7 -alkyl, C 1-7 -alkyl substituted by halogen, halogen, C 1-7 -alkoxy, or C 1-7 -alkoxy substituted by halogen; R 1 may be different if n = 2 or 3 n is 1, 2 or 3 Ar is a six membered heteroaryl group, selected from R 2 is hydrogen, C 1-7 -alkyl, C 1-7 -alkyl substituted by halogen, halogen or C 1-7 -alkoxy; R 3 is hydrogen or halogen; or a pharmaceutically active acid addition salt thereof.
1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 -one or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof for use in a method for treating or preventing glioblastoma multiforme, wherein the method comprises administering an effective amount of said compound to a patient in need thereof.
A metering valve for dispensing fluid, the metering valve comprising: a valve body containing a metering chamber ; and a valve member that slides axially in said valve body between a rest position and a dispensing position, for selectively dispensing the contents of said metering chamber , said valve member including a collar and being urged towards its rest position by a spring that co-operates firstly with said valve body and secondly with said collar , said valve body including a valve-body cylindrical portion in which said collar of said valve member slides between its rest and dispensing positions, the metering valve being characterized in that said valve-body cylindrical portion includes a plurality of longitudinal splines that extend over at least a fraction of the height of said valve-body cylindrical portion , said longitudinal splines projecting radially inwards and acting on said collar of said valve member for substantially centering said collar in said valve-body cylindrical portion .
A valve for a urostomy appliance including: a housing for connection to the urostomy appliance , the housing having an inlet and an outlet , wherein the housing includes a housing passage extending between the inlet and outlet , and a body which is received in the housing passage and which is rotatable about an axis between an open position, in which liquid is permitted to flow to the outlet , and a closed position, in which liquid is substantially prevented from flowing to the outlet , wherein the body is received in the opening in the housing and has a body passage extending from a body inlet to a body outlet , wherein when the body is in its open position the body outlet at least partially aligns with the housing outlet and permits liquid to pass through the body passage and flow through the housing outlet , and wherein the valve includes a sealing device which extends around a periphery of the body between the body and the housing passage and which extends around the body outlet , such that the sealing device prevents ingress of liquid between the body and the housing passage when the body is in its closed position. a housing for connection to the urostomy appliance , the housing having an inlet and an outlet , wherein the housing includes a housing passage extending between the inlet and outlet , and a body which is received in the housing passage and which is rotatable about an axis between an open position, in which liquid is permitted to flow to the outlet , and a closed position, in which liquid is substantially prevented from flowing to the outlet , wherein the body is received in the opening in the housing and has a body passage extending from a body inlet to a body outlet , wherein when the body is in its open position the body outlet at least partially aligns with the housing outlet and permits liquid to pass through the body passage and flow through the housing outlet , and wherein the valve includes a sealing device which extends around a periphery of the body between the body and the housing passage and which extends around the body outlet , such that the sealing device prevents ingress of liquid between the body and the housing passage when the body is in its closed position.
A process for preparing a tin-containing zeolitic material having an MWW-type framework structure comprising (i) providing a zeolitic material having an MWW-type framework structure comprising X 2 O 3 and YO 2 , wherein Y is a tetravalent element selected from the group consisting of Si, Ti, Zr, Ge, and combinations of two or more thereof, wherein Y is preferably Si, and X is a trivalent element selected from the group consisting of Al, B, In, Ga, Fe, and combinations of two or more thereof, wherein X is preferably B, said MWW-type framework structure having vacant tetrahedral framework sites; (ii) providing a tin-ion source in solid form, wherein the tin-ion source is selected from the group consisting of tin(II) alkoxides, tin(IV) alkoxides, tin(II) salts of organic acids, tin(IV) salts of organic acids, and a mixture a two or more thereof; (iii) incorporating tin into the zeolitic material provided in (i) by bringing the zeolitic material provided in (i) in contact with the tin-ion source provided in (ii) under solid-state ion exchange conditions, obtaining a tin-containing zeolitic material having an MWW-type framework structure. (i) providing a zeolitic material having an MWW-type framework structure comprising X 2 O 3 and YO 2 , wherein Y is a tetravalent element selected from the group consisting of Si, Ti, Zr, Ge, and combinations of two or more thereof, wherein Y is preferably Si, and X is a trivalent element selected from the group consisting of Al, B, In, Ga, Fe, and combinations of two or more thereof, wherein X is preferably B, said MWW-type framework structure having vacant tetrahedral framework sites; (ii) providing a tin-ion source in solid form, wherein the tin-ion source is selected from the group consisting of tin(II) alkoxides, tin(IV) alkoxides, tin(II) salts of organic acids, tin(IV) salts of organic acids, and a mixture a two or more thereof; (iii) incorporating tin into the zeolitic material provided in (i) by bringing the zeolitic material provided in (i) in contact with the tin-ion source provided in (ii) under solid-state ion exchange conditions, obtaining a tin-containing zeolitic material having an MWW-type framework structure.
An adsorption pump comprising: a housing having an inlet port and an outlet port for a sample; a movable part at least partly located inside the housing ; and an adsorption part located inside the housing , wherein the movable part includes an impeller including a blade , anc characterized in that the adsorption part is located on a blade surface of the impeller . a housing having an inlet port and an outlet port for a sample; a movable part at least partly located inside the housing ; and an adsorption part located inside the housing , wherein the movable part includes an impeller including a blade , anc characterized in that the adsorption part is located on a blade surface of the impeller .
A silylated polyurethane obtainable by reacting: a) at least one polyol having a number average molecular weight of from 1000 to 50,000 g/mol; b) at least one polyisocyanate, preferably diisocyanate; and c) at least one silicon-containing heterocycle of the general formula (I) wherein R 1 is hydrogen; R 2 and R 3 are same or different and are, independently from one another, selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl residue which may be interrupted by at least one heteroatom; R 4 is selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkylene residue which may be interrupted by at least one heteroatom; R 5 and R 6 are same or different and are, independently from one another, selected from the group consisting of hydrogen, a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl which may be interrupted by at least one heteroatom, and a C 4 -C 8 cycloalkyl, or R 5 and R 6 may form a ring, preferably a 4- to 8-membered alkyl ring; and n is 0, 1 or 2, preferably 2. a) at least one polyol having a number average molecular weight of from 1000 to 50,000 g/mol; b) at least one polyisocyanate, preferably diisocyanate; and c) at least one silicon-containing heterocycle of the general formula (I) wherein R 1 is hydrogen; R 2 and R 3 are same or different and are, independently from one another, selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl residue which may be interrupted by at least one heteroatom; R 4 is selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkylene residue which may be interrupted by at least one heteroatom; R 5 and R 6 are same or different and are, independently from one another, selected from the group consisting of hydrogen, a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl which may be interrupted by at least one heteroatom, and a C 4 -C 8 cycloalkyl, or R 5 and R 6 may form a ring, preferably a 4- to 8-membered alkyl ring; and n is 0, 1 or 2, preferably 2. wherein R 1 is hydrogen; R 2 and R 3 are same or different and are, independently from one another, selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl residue which may be interrupted by at least one heteroatom; R 4 is selected from a linear or branched, substituted or unsubstituted C 1 -C 20 alkylene residue which may be interrupted by at least one heteroatom; R 5 and R 6 are same or different and are, independently from one another, selected from the group consisting of hydrogen, a linear or branched, substituted or unsubstituted C 1 -C 20 alkyl or C 6 -C 18 aryl which may be interrupted by at least one heteroatom, and a C 4 -C 8 cycloalkyl, or R 5 and R 6 may form a ring, preferably a 4- to 8-membered alkyl ring; and n is 0, 1 or 2, preferably 2.
Computer program for self-calibrating a computer brain interface, CBI, device of an individual , comprising instructions for carrying out the following steps, when being executed by the CBI device: choosing a set of test signal parameters; generating, based on the chosen set of test signal parameters, at least one neurostimulation test signal configured to elicit a bioelectric response in one or more afferent sensory nerve fibers ; applying the generated neurostimulation test signal to the afferent sensory nerve fibers via a neurostimulation interface operably connected to or integrated with the CBI device; sensing via the neurostimulation interface, one or more bioelectric responses of the one or more stimulated afferent sensory nerve fibers; determining, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed; if the excitation behavior has changed, determining, based on the sensed bioelectric responses, a set of recalibrated neurostimulation signal parameters; and operating the CBI device, using the recalibrated neurostimulation signal parameters, to communicate information to the individual, via neurostimulation of the one or more afferent sensory nerve fibers. choosing a set of test signal parameters; generating, based on the chosen set of test signal parameters, at least one neurostimulation test signal configured to elicit a bioelectric response in one or more afferent sensory nerve fibers ; applying the generated neurostimulation test signal to the afferent sensory nerve fibers via a neurostimulation interface operably connected to or integrated with the CBI device; sensing via the neurostimulation interface, one or more bioelectric responses of the one or more stimulated afferent sensory nerve fibers; determining, based on the sensed bioelectric responses, whether an excitation behavior of the stimulated afferent sensory nerve fibers with respect to the neurostimulation interface has changed; if the excitation behavior has changed, determining, based on the sensed bioelectric responses, a set of recalibrated neurostimulation signal parameters; and operating the CBI device, using the recalibrated neurostimulation signal parameters, to communicate information to the individual, via neurostimulation of the one or more afferent sensory nerve fibers.
An internal combustion engine (10;20) for power generation, comprising: an engine body having at least one cylinder ; an air-supply pipe connected to the at least one cylinder via an air-supply manifold , comprising an adjustment pipe having a predetermined length and extending from the air-supply manifold , wherein the predetermined length is set so that a first pressure wave propagating from the air-supply manifold toward a farthest end portion of the adjustment pipe and a second pressure wave made by that the first pressure wave having arrived at the farthest end portion is reflected by an inner wall of the adjustment pipe and propagating from the adjustment pipe toward the air-supply manifold have opposite phases from each other, in at least a part of the at least one cylinder, wherein the adjustment pipe is disposed on a bend portion of the air-supply manifold ; and wherein the inlet of the adjustment pipe is disposed so as to face the air-supply pipe or the cylinder ; characterized in that the the predetermined length is set on the basis of an air-supply temperature or an air-fuel mixture composition at the time of a rated output of the engine body, and in that the adjustment pipe includes an airflow resistor for generating airflow resistance against supply air which flows through the adjustment pipe ; said airflow resistor comprising a porous material. an engine body having at least one cylinder ; an air-supply pipe connected to the at least one cylinder via an air-supply manifold , comprising an adjustment pipe having a predetermined length and extending from the air-supply manifold , wherein the predetermined length is set so that a first pressure wave propagating from the air-supply manifold toward a farthest end portion of the adjustment pipe and a second pressure wave made by that the first pressure wave having arrived at the farthest end portion is reflected by an inner wall of the adjustment pipe and propagating from the adjustment pipe toward the air-supply manifold have opposite phases from each other, in at least a part of the at least one cylinder, wherein the adjustment pipe is disposed on a bend portion of the air-supply manifold ; and wherein the inlet of the adjustment pipe is disposed so as to face the air-supply pipe or the cylinder ; characterized in that the the predetermined length is set on the basis of an air-supply temperature or an air-fuel mixture composition at the time of a rated output of the engine body, and in that the adjustment pipe includes an airflow resistor for generating airflow resistance against supply air which flows through the adjustment pipe ; said airflow resistor comprising a porous material.
A two-component nozzle comprising a nozzle body that bounds a flow space which leads to a nozzle opening forming a nozzle outlet; a gas channel for supplying a gas, the gas channel terminating in the flow space , a liquid channel for supplying a liquid, the liquid channel having at least one outlet opening through which the liquid exits into the flow space in order to be charged with the gas in order to form a liquid film in the flow space , wherein the outlet opening defines an outlet direction (A) out of the liquid channel for the liquid, the direction being opposite to a flow direction (S) of the liquid film in the flow space , wherein the liquid channel is formed through a guide body that is configured and arranged so as to divide a liquid flow in the flow space and to guide the liquid flowing to the nozzle opening , wherein the guide body has the form, at least in some section, of an airfoil shape or an elongated drop shape or symmetrical wedge shape in cross-section, wherein a front side of the guide body facing the nozzle opening forms a tearing edge for the liquid film , which is arranged near the nozzle opening .
A method for transmitting data of an exchangeable lens having a plurality of drive target members , drive conditions of which change as a drive force is applied thereto, the method comprising: executing initialization processing of at least one drive target member; receiving an instruction for initialization status request from a camera body to which the exchangeable lens is attached via a first transmission path ; transmitting first data to the camera body via the first transmission path , the first data indicating that the initialization processing of at least one of the drive target members is complete, receiving, after transmitting the first data to the camera body, a drive instruction for the at least one drive target member, the initialization processing of which is complete, via the first transmission path , regardless of whether or not initialization processing of at least one other drive target member of the plurality of drive target members is complete, and transmitting, after transmitting the first data to the camera body, second data indicating drive conditions of the at least one drive target member, the initialization processing of which is complete, via a second transmission path different from the first transmission path. executing initialization processing of at least one drive target member; receiving an instruction for initialization status request from a camera body to which the exchangeable lens is attached via a first transmission path ; transmitting first data to the camera body via the first transmission path , the first data indicating that the initialization processing of at least one of the drive target members is complete, receiving, after transmitting the first data to the camera body, a drive instruction for the at least one drive target member, the initialization processing of which is complete, via the first transmission path , regardless of whether or not initialization processing of at least one other drive target member of the plurality of drive target members is complete, and transmitting, after transmitting the first data to the camera body, second data indicating drive conditions of the at least one drive target member, the initialization processing of which is complete, via a second transmission path different from the first transmission path.
An actuator for a pump, the actuator comprising: a wedge shaped member arranged to move in substantially linear reciprocating motion, a drive member operatively coupled to the wedge shaped member , the wedge shaped member being arranged to deflect the drive member as the wedge shaped member moves, a shape memory material having a first end and a second end, the first end is electrically connected to a first electrical connection terminal and is fixed with respect to the first electrical connection terminal , characterised in that the wedge shaped member is electrically conductive, the second end is electrically connected to the wedge shaped member and is fixed with respect to the wedge shaped member , and the wedge shaped member is electrically connected to a second electrical connection terminal .
A method for retail item management, the method comprising: filtering sensor data obtained by a wireless sensor node, WSN, tag , which is associable or associated with an item in a retail store, the method further comprising applying, at the WSN tag , at least one event filter to sensor data, the sensor data being based at least in part on motion of the WSN tag ; and the at least one event filter including at least one filter parameter, the at least one filter parameter including a minimum amount of movements of the WSN tag within a predetermined time threshold; determining, at the WSN tag , and based on the application of the at least one event filter to the sensor data, whether the at least one event filter is met; and in response to determining that the at least one event filter is met, causing event data associated with the event to be reported to a WSN access point ; wherein the event data at least includes date/time of an event and type of event as determined by the at least one event filter capturing the salient characteristics of item handlings. filtering sensor data obtained by a wireless sensor node, WSN, tag , which is associable or associated with an item in a retail store, the method further comprising applying, at the WSN tag , at least one event filter to sensor data, the sensor data being based at least in part on motion of the WSN tag ; and the at least one event filter including at least one filter parameter, the at least one filter parameter including a minimum amount of movements of the WSN tag within a predetermined time threshold; determining, at the WSN tag , and based on the application of the at least one event filter to the sensor data, whether the at least one event filter is met; and in response to determining that the at least one event filter is met, causing event data associated with the event to be reported to a WSN access point ; wherein the event data at least includes date/time of an event and type of event as determined by the at least one event filter capturing the salient characteristics of item handlings.
A method for producing particles of an active ingredient comprising: (a) forming a first solution by dissolving the active ingredient in a first solvent; and (b) forming the particles of the active ingredient by mixing a second solvent with the first solution to produce an emulsified solution; wherein, the second solvent is miscible with the first solvent, but is immiscible with the first solution; wherein either the active ingredient is paliperidone palmitate, the first solvent is toluene and the second solvent is hexane or heptane; or the active ingredient is ascorbic acid, the first solvent is methanol and the second solvent is water; or the first solvent is tetrahydrofuran and the second solvent is heptane. (a) forming a first solution by dissolving the active ingredient in a first solvent; and (b) forming the particles of the active ingredient by mixing a second solvent with the first solution to produce an emulsified solution; wherein, the second solvent is miscible with the first solvent, but is immiscible with the first solution; wherein either the active ingredient is paliperidone palmitate, the first solvent is toluene and the second solvent is hexane or heptane; or the active ingredient is ascorbic acid, the first solvent is methanol and the second solvent is water; or the first solvent is tetrahydrofuran and the second solvent is heptane.