A microplate comprising: a frame comprising a substantially planar top surface, a bottom surface, and including a plurality of cells formed therein, each cell comprising: a first well; a second well; wherein said first well and said second well are separated by a separation wall extending in a first direction from the bottom surface to the top surface of said frame, and extending in a second direction along a longitudinal axis; and wherein said first well and said second well are connected via at least one vapor communication channel having a dimension, shape, and location to allow vapor communication between said first well and said second well, and to facilitate the inhibition of liquid transfer between said first well and said second well when at least one cell contains a liquid and when said frame is tilted from a horizontal position or when said frame is subjected to impulsive accelerations, wherein said at least one vapor communication channel is carved into the top surface of said frame, wherein a top surface of said separation wall comprises a center point and two end points, and wherein at least one of the following a) wherein said at least one vapor communication channel is jogged or redirected around barriers; b) wherein said at least one vapor communication channel is positioned at a position between the center point and one of the two end points of the top surface of said separation wall; c) wherein said at least one vapor communication channel is positioned at an angle to the longitudinal axis. a first well; a second well; wherein said first well and said second well are separated by a separation wall extending in a first direction from the bottom surface to the top surface of said frame, and extending in a second direction along a longitudinal axis; and wherein said first well and said second well are connected via at least one vapor communication channel having a dimension, shape, and location to allow vapor communication between said first well and said second well, and to facilitate the inhibition of liquid transfer between said first well and said second well when at least one cell contains a liquid and when said frame is tilted from a horizontal position or when said frame is subjected to impulsive accelerations, wherein said at least one vapor communication channel is carved into the top surface of said frame, wherein a top surface of said separation wall comprises a center point and two end points, and wherein at least one of the following a) wherein said at least one vapor communication channel is jogged or redirected around barriers; b) wherein said at least one vapor communication channel is positioned at a position between the center point and one of the two end points of the top surface of said separation wall; c) wherein said at least one vapor communication channel is positioned at an angle to the longitudinal axis. a) wherein said at least one vapor communication channel is jogged or redirected around barriers; b) wherein said at least one vapor communication channel is positioned at a position between the center point and one of the two end points of the top surface of said separation wall; c) wherein said at least one vapor communication channel is positioned at an angle to the longitudinal axis. <EOS>