A dry powder inhalation device comprising: a chamber ; a patient port in communication with said chamber ; a storage device comprising a cassette , an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, said powder being releasably retained on a surface of the carrier, and a moisture barrier sealing system ; an advancement mechanism for advancing a portion of the carrier within the chamber so that the powder associated with an advanced area of the carrier can be released from the carrier for inhalation by a patient through the patient port ; and a hammer configured to strike the portion of the carrier within the chamber to release at least some of the powder from the carrier , characterized in that , the moisture barrier sealing system comprises a first clamping system and in that the storage device further comprises a second clamping system , wherein said storage device is configured and arranged such that during use in a dry powder inhaler a portion of the carrier is advanced out of the cassette so that the powder associated with an advanced area can be released from the carrier for inhalation by a patient, and the first and second clamping systems are configured to be moved into a clamping configuration at least prior to release of the powder associated with said area of the carrier , so that said area of the carrier will be clamped between the first and the second clamping systems during release of the powder associated with said area of the carrier ; further characterized in that at least one of the first and second clamping systems comprises a grip. a chamber ; a patient port in communication with said chamber ; a storage device comprising a cassette , an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, said powder being releasably retained on a surface of the carrier, and a moisture barrier sealing system ; an advancement mechanism for advancing a portion of the carrier within the chamber so that the powder associated with an advanced area of the carrier can be released from the carrier for inhalation by a patient through the patient port ; and a hammer configured to strike the portion of the carrier within the chamber to release at least some of the powder from the carrier , characterized in that , the moisture barrier sealing system comprises a first clamping system and in that the storage device further comprises a second clamping system , wherein said storage device is configured and arranged such that during use in a dry powder inhaler a portion of the carrier is advanced out of the cassette so that the powder associated with an advanced area can be released from the carrier for inhalation by a patient, and the first and second clamping systems are configured to be moved into a clamping configuration at least prior to release of the powder associated with said area of the carrier , so that said area of the carrier will be clamped between the first and the second clamping systems during release of the powder associated with said area of the carrier ; further characterized in that at least one of the first and second clamping systems comprises a grip. <EOS>