mhurhangee/patent-ind-claim-en huggingface dataset:
An immune cell, comprising: a. a first receptor, comprising an extracellular ligand binding domain specific to Epidermal Growth Factor Receptor (EGFR); and b. a second receptor, comprising an extracellular ligand binding domain specific to a non-target antigen lost in EGFR+ cancer due to loss of heterozygosity, wherein the first receptor is an activator receptor responsive to EGFR; and wherein the second receptor is an inhibitory receptor responsive to the non-target antigen, wherein the extracellular ligand binding domain of the second receptor specifically binds HLA-A*02, and wherein the extracellular ligand binding domain of the first receptor comprises complementarity determining regions (CDRs) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, and CDR-H3 of SEQ ID NOs: 154, 155, 156, 151, 152, and 153, and wherein the extracellular ligand binding domain of the second receptor comprises complementarity determining regions CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, CDR-H3 of the humanized scFv binding domain sequence of C-002162 PA2.1.14 as depicted in Table 4, wherein the CDR-L1 sequence is RSSQSIVHSNGNTYLE (SEQ ID NO: 101), the CDR-L2 sequence is KVSNRFSGVPAR, the CDR-L3 sequence is FQGSHVPRT (SEQ ID NO: 103), the CDR-H1 sequence is ASGYTFTSYHIH (SEQ ID NO: 104), the CDR-H2 sequence is WIYPGNVNTEYNEKFKGK (SEQ ID NO: 105), and the CDR-H3 sequence is EEITYAMDY (SEQ ID NO: 106), wherein the immune cell is a CD8+ CD4- T cell or a CD8- CD4+ T cell. a. a first receptor, comprising an extracellular ligand binding domain specific to Epidermal Growth Factor Receptor (EGFR); and b. a second receptor, comprising an extracellular ligand binding domain specific to a non-target antigen lost in EGFR+ cancer due to loss of heterozygosity, wherein the first receptor is an activator receptor responsive to EGFR; and wherein the second receptor is an inhibitory receptor responsive to the non-target antigen, wherein the extracellular ligand binding domain of the second receptor specifically binds HLA-A*02, and wherein the extracellular ligand binding domain of the first receptor comprises complementarity determining regions (CDRs) CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, and CDR-H3 of SEQ ID NOs: 154, 155, 156, 151, 152, and 153, and wherein the extracellular ligand binding domain of the second receptor comprises complementarity determining regions CDR-L1, CDR-L2, CDR-L3, CDR-H1, CDR-H2, CDR-H3 of the humanized scFv binding domain sequence of C-002162 PA2.1.14 as depicted in Table 4, wherein the CDR-L1 sequence is RSSQSIVHSNGNTYLE (SEQ ID NO: 101), the CDR-L2 sequence is KVSNRFSGVPAR, the CDR-L3 sequence is FQGSHVPRT (SEQ ID NO: 103), the CDR-H1 sequence is ASGYTFTSYHIH (SEQ ID NO: 104), the CDR-H2 sequence is WIYPGNVNTEYNEKFKGK (SEQ ID NO: 105), and the CDR-H3 sequence is EEITYAMDY (SEQ ID NO: 106), wherein the immune cell is a CD8+ CD4- T cell or a CD8- CD4+ T cell.
Method of mounting a first cladding panel and a second cladding panel between a first stabilizing element and a second stabilizing element of an escalator , comprising the steps of: forming a butt joint by placing the first cladding panel and the second cladding panel between the first stabilizing element and the second stabilizing element , wherein the first cladding panel and the second cladding panel abut the first stabilizing element ; and arranging at least one first spring in the region of the butt joint , wherein the at least one first spring presses the first cladding panel and the second cladding panel against the first stabilizing element with a first end in order to fix the first cladding panel and the second cladding panel , and is supported with a second end at the second stabilizing element , characterized in that at least one stiffening profile extending along said butt joint is provided, and said at least first spring is disposed between said stiffening profile and the second stabilizing element . forming a butt joint by placing the first cladding panel and the second cladding panel between the first stabilizing element and the second stabilizing element , wherein the first cladding panel and the second cladding panel abut the first stabilizing element ; and arranging at least one first spring in the region of the butt joint , wherein the at least one first spring presses the first cladding panel and the second cladding panel against the first stabilizing element with a first end in order to fix the first cladding panel and the second cladding panel , and is supported with a second end at the second stabilizing element , characterized in that at least one stiffening profile extending along said butt joint is provided, and said at least first spring is disposed between said stiffening profile and the second stabilizing element .
Securing apparatus for a steering column for a motor vehicle, which securing apparatus can be used between a casing unit and a steering shaft which is mounted rotatably in the said casing unit , for temporarily blocking a rotational movement of the steering shaft relative to the casing unit , comprising an elongate bar element which extends in the longitudinal direction (E), and to one end of which a handle element is attached and the other end of which is configured as a free end which is configured from plastic material, a reinforcing element extending at least over a part region of the longitudinal direction (E) of the bar element , characterized in that the reinforcing element is configured as a tensile reinforcing element which is enclosed at least partially or completely by the material of the bar element , and which is connected to the plastic material of the bar element in a tension-resistant manner in the longitudinal direction (E), the bar element being configured as a plastic injection moulded part, and the tensile reinforcing element being overmoulded by the plastic material.
A method of injecting flammable gas into a diesel fuel engine for combustion with diesel fuel therein, the method including the steps of: - injecting flammable gas into an air-stream of an engine air intake or manifold; and - measuring directly or by a secondary LPG concentration sensor, the percentage of flammable gas injected into the airstream; the method characterised by - varying the rate of injection of flammable gas into the airstream in response to the measured percentage of flammable gas therein and injecting the flammable gas at a pre-determined rate so as to always maintain a flammable gas concentration in the air intake stream in the range of 0.2% to 0.6% by volume of flammable gas. - injecting flammable gas into an air-stream of an engine air intake or manifold; and - measuring directly or by a secondary LPG concentration sensor, the percentage of flammable gas injected into the airstream; the method characterised by - varying the rate of injection of flammable gas into the airstream in response to the measured percentage of flammable gas therein and injecting the flammable gas at a pre-determined rate so as to always maintain a flammable gas concentration in the air intake stream in the range of 0.2% to 0.6% by volume of flammable gas.
A biopsy incision device comprising a proximal side , to be arranged on a skin surface, and a distal side , said distal side comprising a blade actuator associated with at least one cutting blade , said blade actuator and said at least one cutting blade being suspended at a pivoting point on said distal side , such that said blade actuator and said at least one cutting blade may pivot around a pivoting axis (A), such that said at least one cutting blade may cut said skin surface, wherein the at least one cutting blade is formed with two cutting blades, arranged such that their proximal edges substantially meet, wherein the blades are configured with a curvature, characterized in that the two cutting blades are configured to pivot around the common pivoting axis (A) which is formed at the pivoting point .
An electrostatic coalescing device comprising: - a vessel or a pipe through which a fluid to be treated may flow, - at least one metal electrode plate and transformer arranged inside said pipe/vessel , wherein the metal electrode plate and the transformer are fully enclosed by insulation to form a module, and wherein said transformer comprises a low voltage connection so that it can be electrically connected to an external alternating low voltage source/power supply located outside the vessel/pipe , said transformer having a first end of a high voltage winding connected electrically to the metal plate within the insulation , wherein the module is configured to be fully submerged in the flow to be treated. - a vessel or a pipe through which a fluid to be treated may flow, - at least one metal electrode plate and transformer arranged inside said pipe/vessel , wherein the metal electrode plate and the transformer are fully enclosed by insulation to form a module, and wherein said transformer comprises a low voltage connection so that it can be electrically connected to an external alternating low voltage source/power supply located outside the vessel/pipe , said transformer having a first end of a high voltage winding connected electrically to the metal plate within the insulation ,
An information processing system comprising: an acquisition means for acquiring information used to generate a virtual viewpoint content; and a generation means for generating the virtual viewpoint content based on the information acquired by the acquisition means, the acquisition means includes: a first acquisition means for acquiring a plurality of images based on synchronous image capturing performed by a plurality of imaging devices (101a to 101n); characterized in that the acquisition means further includes: a second acquisition means for obtaining viewpoint information for specifying a position of a virtual viewpoint and a line-of-sight direction from the virtual viewpoint, image format information indicating an image format for providing the virtual viewpoint content, and time code information indicating a time code that indicates an image capturing timing of synchronous image capturing performed by the plurality of imaging devices (101a to 101n); wherein the generation means is configured to generate a virtual viewpoint content corresponding to an image format indicated by the image format information acquired by the second acquisition means based on the plurality of images which are acquired by the first acquisition means and which correspond to a time code indicated by the time code information acquired by the second acquisition means and based on the viewpoint information acquired by the second acquisition means . an acquisition means for acquiring information used to generate a virtual viewpoint content; and a generation means for generating the virtual viewpoint content based on the information acquired by the acquisition means, the acquisition means includes: a first acquisition means for acquiring a plurality of images based on synchronous image capturing performed by a plurality of imaging devices (101a to 101n); characterized in that the acquisition means further includes: a second acquisition means for obtaining viewpoint information for specifying a position of a virtual viewpoint and a line-of-sight direction from the virtual viewpoint, image format information indicating an image format for providing the virtual viewpoint content, and time code information indicating a time code that indicates an image capturing timing of synchronous image capturing performed by the plurality of imaging devices (101a to 101n); wherein the generation means is configured to generate a virtual viewpoint content corresponding to an image format indicated by the image format information acquired by the second acquisition means based on the plurality of images which are acquired by the first acquisition means and which correspond to a time code indicated by the time code information acquired by the second acquisition means and based on the viewpoint information acquired by the second acquisition means .
Composite granules comprising: a binder; and a metal-containing polymeric material comprising: a) a polymer comprising: i) 15 to 65 wt-% of a first monomeric unit that is of Formula (I), Formula (II), or a mixture thereof: ii) 30 to 85 wt-% of a second monomeric unit that is of Formula (III): and iii) 0 to 40 wt-% of a third monomeric unit that is of Formula (IV): wherein each R 1 is independently hydrogen or an alkyl group; and each asterisk (*) in Formulas (I) to (IV) indicates the attachment sight to another monomeric unit or to a terminal group in the polymeric material; and b) a divalent metal incorporated into the polymeric material, wherein the divalent metal is present in an amount equal to or at least 1.5 mmol per gram of the polymeric material wherein the divalent material is incorporated into the polymeric material by treating the polymeric material with a solution of a divalent metal salt dissolved in water. a binder; and a metal-containing polymeric material comprising: a) a polymer comprising: i) 15 to 65 wt-% of a first monomeric unit that is of Formula (I), Formula (II), or a mixture thereof: ii) 30 to 85 wt-% of a second monomeric unit that is of Formula (III): and iii) 0 to 40 wt-% of a third monomeric unit that is of Formula (IV): wherein each R 1 is independently hydrogen or an alkyl group; and each asterisk (*) in Formulas (I) to (IV) indicates the attachment sight to another monomeric unit or to a terminal group in the polymeric material; and b) a divalent metal incorporated into the polymeric material, wherein the divalent metal is present in an amount equal to or at least 1.5 mmol per gram of the polymeric material wherein the divalent material is incorporated into the polymeric material by treating the polymeric material with a solution of a divalent metal salt dissolved in water. a) a polymer comprising: i) 15 to 65 wt-% of a first monomeric unit that is of Formula (I), Formula (II), or a mixture thereof: ii) 30 to 85 wt-% of a second monomeric unit that is of Formula (III): and iii) 0 to 40 wt-% of a third monomeric unit that is of Formula (IV): wherein each R 1 is independently hydrogen or an alkyl group; and each asterisk (*) in Formulas (I) to (IV) indicates the attachment sight to another monomeric unit or to a terminal group in the polymeric material; and i) 15 to 65 wt-% of a first monomeric unit that is of Formula (I), Formula (II), or a mixture thereof: ii) 30 to 85 wt-% of a second monomeric unit that is of Formula (III): and iii) 0 to 40 wt-% of a third monomeric unit that is of Formula (IV): wherein each R 1 is independently hydrogen or an alkyl group; and each asterisk (*) in Formulas (I) to (IV) indicates the attachment sight to another monomeric unit or to a terminal group in the polymeric material; and b) a divalent metal incorporated into the polymeric material, wherein the divalent metal is present in an amount equal to or at least 1.5 mmol per gram of the polymeric material wherein the divalent material is incorporated into the polymeric material by treating the polymeric material with a solution of a divalent metal salt dissolved in water.
A drywall construction system comprising a plurality of metal profiles , which are panelled at least on one side with dry construction boards , wherein spring rails are arranged at least on this one side between the metal profiles and the dry construction boards , characterised in that the spring rails are top-hat rails , in that the metal profiles have a sheet thickness between 1 mm and max. 3 mm, in that the metal profiles comprise flanges, and in that the spring rails are fastened by means of screws to the flanges of the metal profiles .
Use of a device for adjusting an object , comprising: a rotatably mounted pressure spindle ; a torque motor with a stator and a rotor for rotating the pressure spindle , wherein the stator is constructed in the form of at least one electromagnetic coil and is mounted in stationary location; a pressure nut , which is arranged in stationary location and which is disposed in rotationally coupled engagement with the pressure spindle by way of a thread in order to generate an axial movement of the pressure spindle in the case of rotation thereof and to generate and transmit an axial adjusting force to the object ; wherein the torque motor is constructed as an internal runner, wherein the rotor rotates in the stator ; the rotor of the torque motor is constructed in the form of a rotatably mounted splined hub and the motor-side end of the pressure spindle is constructed in the form of a splined shaft which is pushed into the splined hub and for rotation of the pressure spindle is disposed in rotationally coupled engagement with the splined hub ; characterised in that the device is used for adjusting a roll as the object in a roll stand for the rolling of metallic rolling material. a rotatably mounted pressure spindle ; a torque motor with a stator and a rotor for rotating the pressure spindle , wherein the stator is constructed in the form of at least one electromagnetic coil and is mounted in stationary location; a pressure nut , which is arranged in stationary location and which is disposed in rotationally coupled engagement with the pressure spindle by way of a thread in order to generate an axial movement of the pressure spindle in the case of rotation thereof and to generate and transmit an axial adjusting force to the object ; wherein the torque motor is constructed as an internal runner, wherein the rotor rotates in the stator ; the rotor of the torque motor is constructed in the form of a rotatably mounted splined hub and the motor-side end of the pressure spindle is constructed in the form of a splined shaft which is pushed into the splined hub and for rotation of the pressure spindle is disposed in rotationally coupled engagement with the splined hub ; characterised in that the device is used for adjusting a roll as the object in a roll stand for the rolling of metallic rolling material.
A method performed by a user equipment, UE , connected to a first network, the method comprising: generating first control information for a data packet for selecting a network among the first network and a second network, wherein the first control information includes at least one of first priority information and first criteria for network selection, and the first priority information is determined based on the first criteria; transmitting, to a packet data network gateway, PGW , a request message for requesting a connection to the second network, the request message including the first control information; receiving, from the PGW , a response message as a response to the request message; in case that second control information including at least one of second priority information and second criteria for network selection is in the response message, selecting the network satisfying the second criteria based on the second priority information, the second control information being identified based on the first control information; in case that the second control information is not in the response message, selecting the network satisfying the first criteria based on the first priority information; and transmitting the data packet based on the selected network, wherein the second priority information is determined based on the second criteria. generating first control information for a data packet for selecting a network among the first network and a second network, wherein the first control information includes at least one of first priority information and first criteria for network selection, and the first priority information is determined based on the first criteria; transmitting, to a packet data network gateway, PGW , a request message for requesting a connection to the second network, the request message including the first control information; receiving, from the PGW , a response message as a response to the request message; in case that second control information including at least one of second priority information and second criteria for network selection is in the response message, selecting the network satisfying the second criteria based on the second priority information, the second control information being identified based on the first control information; in case that the second control information is not in the response message, selecting the network satisfying the first criteria based on the first priority information; and transmitting the data packet based on the selected network, wherein the second priority information is determined based on the second criteria.
A method for the synthesis of a compound comprising an indane moiety having a chiral carbon in the five-membered ring of the indane moiety where the compound is enantiomerically enriched with respect to the chiral carbon, the method comprising the steps of: (i) providing an indane moiety where the ring carbon of the five-membered ring of the indane moiety where chiral substitution is desired is oxo substituted at such carbon, the compound having the following structure: (ii) reacting the compound of step (i) with a chiral reagent, wherein the chiral agent is t-Bu-S(=O)NH2, thereby forming a compound of one of the following structures: (iii) forming a chiral center at the indane moiety carbon previously bound to the oxo group by reacting the compound of step (ii) with a reducing agent, thereby forming a compound of one of the following structures: (iv) converting the compound of step (iii) to a chiral amine, thereby forming a compound of one of the following structures: (v) converting the compound of step (iv) to a protected chiral amine, thereby forming a compound of one of the following structures: (vi) reacting the compound of step (v) with R"-halide wherein R" is -CH 2 CH 2 OTBS, thereby forming a compound of one of the following structures: and (vii) treating the compound of step (vi) with a hydroxylamine or a hydroxylamine hydrochloride to convert the cyano substituent to a hydroxyamidine at the 4-position of the indane moiety, thereby forming a compound of one of the following structures: (i) providing an indane moiety where the ring carbon of the five-membered ring of the indane moiety where chiral substitution is desired is oxo substituted at such carbon, the compound having the following structure: (ii) reacting the compound of step (i) with a chiral reagent, wherein the chiral agent is t-Bu-S(=O)NH2, thereby forming a compound of one of the following structures: (iii) forming a chiral center at the indane moiety carbon previously bound to the oxo group by reacting the compound of step (ii) with a reducing agent, thereby forming a compound of one of the following structures: (iv) converting the compound of step (iii) to a chiral amine, thereby forming a compound of one of the following structures: (v) converting the compound of step (iv) to a protected chiral amine, thereby forming a compound of one of the following structures: (vi) reacting the compound of step (v) with R"-halide wherein R" is -CH 2 CH 2 OTBS, thereby forming a compound of one of the following structures: and (vii) treating the compound of step (vi) with a hydroxylamine or a hydroxylamine hydrochloride to convert the cyano substituent to a hydroxyamidine at the 4-position of the indane moiety, thereby forming a compound of one of the following structures: