A medical device for delivering therapeutic material to a patient, the device comprising: an access sheath having a proximal section extending to a distal section and a working lumen formed in the proximal and distal sections, the distal section having a plurality of side ports formed therethrough in fluid communication with the working lumen, the plurality of the side ports being arranged at 90 degrees, 120 degrees, 180 degrees or other radial intervals, the distal section having a deflection section actuatable to bend at an angle for positioning the side ports in the patient; and a needle assembly configured to move within the working lumen between a retracted position and an extended position, the needle assembly including: a main cannula having a proximal portion extending to a distal portion ; and a plurality of needles arranged such that the needles are disposed within the access sheath in the retracted position and the needles extend through the side ports outwardly from the access sheath in the extended position to deliver the therapeutic material to the patient; characterised in that the main cannula comprises a central lumen formed in the proximal and distal portions, the central lumen being configured to advance the therapeutic material, the plurality of needles being in fluid communication with the central lumen, the needles being attached to the distal portion of the main cannula and extending distally therefrom. an access sheath having a proximal section extending to a distal section and a working lumen formed in the proximal and distal sections, the distal section having a plurality of side ports formed therethrough in fluid communication with the working lumen, the plurality of the side ports being arranged at 90 degrees, 120 degrees, 180 degrees or other radial intervals, the distal section having a deflection section actuatable to bend at an angle for positioning the side ports in the patient; and a needle assembly configured to move within the working lumen between a retracted position and an extended position, the needle assembly including: a main cannula having a proximal portion extending to a distal portion ; and a plurality of needles arranged such that the needles are disposed within the access sheath in the retracted position and the needles extend through the side ports outwardly from the access sheath in the extended position to deliver the therapeutic material to the patient; characterised in that the main cannula comprises a central lumen formed in the proximal and distal portions, the central lumen being configured to advance the therapeutic material, the plurality of needles being in fluid communication with the central lumen, the needles being attached to the distal portion of the main cannula and extending distally therefrom. a main cannula having a proximal portion extending to a distal portion ; and a plurality of needles arranged such that the needles are disposed within the access sheath in the retracted position and the needles extend through the side ports outwardly from the access sheath in the extended position to deliver the therapeutic material to the patient; characterised in that the main cannula comprises a central lumen formed in the proximal and distal portions, the central lumen being configured to advance the therapeutic material, the plurality of needles being in fluid communication with the central lumen, the needles being attached to the distal portion of the main cannula and extending distally therefrom. <EOS>