A compound of formula I: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein: W 1 , W 2 , W 3 , and W 4 are each independently selected from hydrogen and fluorine, provided that at least one of W 1 , W 2 , W 3 , and W 4 is not hydrogen; X 1 and X 5 are each independently selected from hydrogen, halogen and C 1 -C 3 alkyl; X 3 is selected from halogen and NR 1 C(O)R 2 ; X 2 and X 4 are each independently hydrogen or halogen, provided that one or two of X 2 , and X 4 is hydrogen; R 1 is selected from hydrogen and C 1 -C 8 alkyl; R 2 is selected from hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring are unsubstituted or substituted with one or more R b ; R b is selected from halogen, C 1 -C 8 alkyl, CF 3 , CHF 2 , CH 2 F, NH 2 , NHCH 3 , N(CH 3 ) 2 , C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring are unsubstituted or substituted with one or more R b1 ; R b1 is selected from halogen, C 1 -C 3 alkyl, CF 3 , CHF 2 , CH 2 F, OH, OCH 3 , SOCH 3 , S(O) 2 CH 3 , NH 2 , NHCH 3 , and N(CH 3 ) 2 ; and each aromatic ring is independently a carbocyclic aromatic system containing one, two or three rings; provided that said compound is not of the formula: W 1 , W 2 , W 3 , and W 4 are each independently selected from hydrogen and fluorine, provided that at least one of W 1 , W 2 , W 3 , and W 4 is not hydrogen; X 1 and X 5 are each independently selected from hydrogen, halogen and C 1 -C 3 alkyl; X 3 is selected from halogen and NR 1 C(O)R 2 ; X 2 and X 4 are each independently hydrogen or halogen, provided that one or two of X 2 , and X 4 is hydrogen; R 1 is selected from hydrogen and C 1 -C 8 alkyl; R 2 is selected from hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 3 -C 8 alkynyl, C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring are unsubstituted or substituted with one or more R b ; R b is selected from halogen, C 1 -C 8 alkyl, CF 3 , CHF 2 , CH 2 F, NH 2 , NHCH 3 , N(CH 3 ) 2 , C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring are unsubstituted or substituted with one or more R b1 ; R b1 is selected from halogen, C 1 -C 3 alkyl, CF 3 , CHF 2 , CH 2 F, OH, OCH 3 , SOCH 3 , S(O) 2 CH 3 , NH 2 , NHCH 3 , and N(CH 3 ) 2 ; and each aromatic ring is independently a carbocyclic aromatic system containing one, two or three rings; <EOS>