mhurhangee/patent-ind-claim-en huggingface dataset:
A long-acting compstatin analog (LACA) for use in treating a complement-mediated eye disorder in a subject in need thereof; wherein (a) said LACA consists of a clearance-reducing moiety attached to two compstatin analog moieties, wherein each compstatin analog moiety consists of a cyclic peptide having the amino acid sequence as set forth in SEQ ID NO: 28 extended by a lysine residue at the C-terminus, wherein the lysine residue is separated from the cyclic portion of the peptide by an 8-amino-3,6-dioxaoctanoic acid (AEEAc) spacer; the clearance reducing moiety comprises a polymer, wherein each end of the polymer is linked to the amino group of the side chain of the lysine residue of one of the compstatin analog moieties by way of a carbamate, wherein the polymer is PEG having an average molecular weight of 40 kD; and (b) said complement-mediated eye disorder is age-related macular degeneration (AMD), optionally geographic atrophy or intermediate AMD; and (c) said use comprises intravitreally administering said LACA to an eye of said subject in an amount of between 10 mg and 20 mg, optionally wherein the amount is 15 mg. (a) said LACA consists of a clearance-reducing moiety attached to two compstatin analog moieties, wherein each compstatin analog moiety consists of a cyclic peptide having the amino acid sequence as set forth in SEQ ID NO: 28 extended by a lysine residue at the C-terminus, wherein the lysine residue is separated from the cyclic portion of the peptide by an 8-amino-3,6-dioxaoctanoic acid (AEEAc) spacer; the clearance reducing moiety comprises a polymer, wherein each end of the polymer is linked to the amino group of the side chain of the lysine residue of one of the compstatin analog moieties by way of a carbamate, wherein the polymer is PEG having an average molecular weight of 40 kD; and each compstatin analog moiety consists of a cyclic peptide having the amino acid sequence as set forth in SEQ ID NO: 28 extended by a lysine residue at the C-terminus, wherein the lysine residue is separated from the cyclic portion of the peptide by an 8-amino-3,6-dioxaoctanoic acid (AEEAc) spacer; the clearance reducing moiety comprises a polymer, wherein each end of the polymer is linked to the amino group of the side chain of the lysine residue of one of the compstatin analog moieties by way of a carbamate, wherein the polymer is PEG having an average molecular weight of 40 kD; and (b) said complement-mediated eye disorder is age-related macular degeneration (AMD), optionally geographic atrophy or intermediate AMD; and (c) said use comprises intravitreally administering said LACA to an eye of said subject in an amount of between 10 mg and 20 mg, optionally wherein the amount is 15 mg.
A method comprising: sending , by a user equipment, UE, an uplink control message to a network device, the uplink control message specifying a duration of an uplink radio frequency, RF, retuning time and a downlink RF retuning time, wherein the uplink RF retuning time and the downlink RF retuning time are associated with switching from a first component carrier to a second component carrier; transmitting , by the UE, a first uplink signal over the first component carrier during a first period, the first uplink signal carrying at least a first sounding reference signal, SRS symbol; switching , by the UE, from the first component carrier to the second component carrier according to an SRS switching scheduling; and transmitting , by the UE, a second uplink signal over the second component carrier during a second period, the second uplink signal carrying at least one of a second SRS symbol and a random access preamble. sending , by a user equipment, UE, an uplink control message to a network device, the uplink control message specifying a duration of an uplink radio frequency, RF, retuning time and a downlink RF retuning time, wherein the uplink RF retuning time and the downlink RF retuning time are associated with switching from a first component carrier to a second component carrier; transmitting , by the UE, a first uplink signal over the first component carrier during a first period, the first uplink signal carrying at least a first sounding reference signal, SRS symbol; switching , by the UE, from the first component carrier to the second component carrier according to an SRS switching scheduling; and transmitting , by the UE, a second uplink signal over the second component carrier during a second period, the second uplink signal carrying at least one of a second SRS symbol and a random access preamble.
An impact protection reinforcement of a vehicle construction, which is supportively fastenable in the vehicle construction against the impact of external mechanical extraordinary load conditions and which comprises the following features: a. an elongated profile element with a longitudinal center line (M L ) and a transverse center line (M Q ) arranged transversely to the longitudinal center line (M L ), the profile element having in the longitudinal direction at each end side a fastening end (20; 30) and a central part therebetween, b. the central part consists of a circumferentially closed hollow profile with a base layer and a top layer arranged opposite to the base layer , which are connected to each other via lateral faces , and c. the fastening ends (20; 30) each have a planar shape with at least two fastening points which are spaced apart differently from the transverse center line (M Q ) and the longitudinal center line (M L ) and are provided as connection points, in particular as welding connection points, to the vehicle construction, characterized in that d. the base layer and the top layer of the hollow profile of the central part have a greater thickness than the connecting lateral faces and e. the impact protection reinforcement has at least at one fastening end (20; 30) only two fastening points for one connection means each, which are spaced apart from each other in the transverse and the longitudinal direction of the impact protection reinforcement . a. an elongated profile element with a longitudinal center line (M L ) and a transverse center line (M Q ) arranged transversely to the longitudinal center line (M L ), the profile element having in the longitudinal direction at each end side a fastening end (20; 30) and a central part therebetween, b. the central part consists of a circumferentially closed hollow profile with a base layer and a top layer arranged opposite to the base layer , which are connected to each other via lateral faces , and c. the fastening ends (20; 30) each have a planar shape with at least two fastening points which are spaced apart differently from the transverse center line (M Q ) and the longitudinal center line (M L ) and are provided as connection points, in particular as welding connection points, to the vehicle construction, characterized in that d. the base layer and the top layer of the hollow profile of the central part have a greater thickness than the connecting lateral faces and e. the impact protection reinforcement has at least at one fastening end (20; 30) only two fastening points for one connection means each, which are spaced apart from each other in the transverse and the longitudinal direction of the impact protection reinforcement .
A battery module comprising: a plurality of battery cells having two opposite ends; a first busbar assembly comprising at least a first busbar coupled with a first busbar frame , and a second busbar assembly comprising at least a second busbar coupled with a second busbar frame configured to electrically couple the battery cells ; and a main frame having side walls (112A - D) forming a housing and a middle wall inside the housing dividing an inner space of the housing in a vertical direction to a first and a second section (116A - B), wherein the middle wall comprises a plurality of holes for receiving the battery cells such that one end of each battery cell is in the first section and another end is in the second section , and wherein the middle wall is substantially in the middle of the battery cells in the vertical direction supporting the battery cells substantially from the middle, and wherein the middle wall further comprises a plurality fastening members for fastening the first busbar assembly to the main frame in the first section and the second busbar assembly to the main frame in the second section such that the battery cells are arranged between the first and the second busbar assemblies (104A - B) which couple the battery cells to the battery module . a plurality of battery cells having two opposite ends; a first busbar assembly comprising at least a first busbar coupled with a first busbar frame , and a second busbar assembly comprising at least a second busbar coupled with a second busbar frame configured to electrically couple the battery cells ; and a main frame having side walls (112A - D) forming a housing and a middle wall inside the housing dividing an inner space of the housing in a vertical direction to a first and a second section (116A - B), wherein the middle wall comprises a plurality of holes for receiving the battery cells such that one end of each battery cell is in the first section and another end is in the second section , and wherein the middle wall is substantially in the middle of the battery cells in the vertical direction supporting the battery cells substantially from the middle, and wherein the middle wall further comprises a plurality fastening members for fastening the first busbar assembly to the main frame in the first section and the second busbar assembly to the main frame in the second section such that the battery cells are arranged between the first and the second busbar assemblies (104A - B) which couple the battery cells to the battery module .
Kelly bar arrangement for a drilling apparatus , in particular an earth drilling apparatus, with a tubular outer Kelly bar , which is designed for bearing on a drill drive and for receiving a drilling torque of the drill drive , and with an inner Kelly bar , which is displaceably supported inside the outer Kelly bar and has a rope suspension , wherein the drilling torque can be transmitted between the outer Kelly bar and the inner Kelly bar , characterized in that on the inner Kelly bar at least one line is arranged, in that in a lower or upper end region of the inner Kelly bar a rotary feedthrough with a first attachment section and a second attachment section is arranged, wherein the first attachment section is connected in a torque-proof manner to the rotationally drivable inner Kelly bar and forms a line connection to the at least one line of the inner Kelly bar and the second attachment section is connected to a supply line which is stationary relative to the rotationally drivable inner Kelly bar , and in that on the rotary feedthrough a rotary means is arranged for actively rotating the two attachment sections relative to each other. with an inner Kelly bar , which is displaceably supported inside the outer Kelly bar and has a rope suspension , wherein the drilling torque can be transmitted between the outer Kelly bar and the inner Kelly bar , characterized in that on the inner Kelly bar at least one line is arranged, in that in a lower or upper end region of the inner Kelly bar a rotary feedthrough with a first attachment section and a second attachment section is arranged, wherein the first attachment section is connected in a torque-proof manner to the rotationally drivable inner Kelly bar and forms a line connection to the at least one line of the inner Kelly bar and the second attachment section is connected to a supply line which is stationary relative to the rotationally drivable inner Kelly bar , and in that on the rotary feedthrough a rotary means is arranged for actively rotating the two attachment sections relative to each other.
Trim element for a pillar of a body of a motor vehicle, in particular for an A-pillar, having a main body ; an exterior of the main body , which exterior faces a vehicle interior when the trim element is installed on the pillar, an interior of the main body , which interior faces the body when the trim element is installed on the pillar, a textile element which covers the exterior and has a plurality of edge portions folded over onto the interior , and a bending portion which extends substantially in a longitudinal direction of the trim element and is formed in the main body ; and a pivoting portion of the main body , which pivoting portion runs along the bending portion , wherein the pivoting portion is connected to the bending portion and is pivotable about the bending portion when force is applied, wherein the trim element is configured to receive an inflatable air bag in its uninflated state, characterised in that at least one edge portion of the textile element is arranged on the interior above the bending portion and is integrally connected to the interior at a plurality of joints (30-1, 30-2), wherein the joints (30-1, 30-2) are arranged along the bending portion . an exterior of the main body , which exterior faces a vehicle interior when the trim element is installed on the pillar, an interior of the main body , which interior faces the body when the trim element is installed on the pillar, a textile element which covers the exterior and has a plurality of edge portions folded over onto the interior , and a bending portion which extends substantially in a longitudinal direction of the trim element and is formed in the main body ; and a pivoting portion of the main body , which pivoting portion runs along the bending portion , wherein the pivoting portion is connected to the bending portion and is pivotable about the bending portion when force is applied, wherein the trim element is configured to receive an inflatable air bag in its uninflated state, characterised in that at least one edge portion of the textile element is arranged on the interior above the bending portion and is integrally connected to the interior at a plurality of joints (30-1, 30-2), wherein the joints (30-1, 30-2) are arranged along the bending portion .
A base station , comprising: an antenna array configured to transmit beam-steered signals in each of a plurality of sub-sectors within a sector; and a transmitter configured to cause the antenna array to transmit a sequence of primary synchronization symbols (P1, P2, P3, P4) within predetermined symbol positions in at least one slot of a subframe and to re-transmit the first transmitted primary synchronization symbol of the sequence of primary synchronization symbols within at least one symbol position followed by the said predetermined symbol positions in the at least one slot, wherein the sequence of primary synchronization symbols includes primary synchronization symbols transmitted on different sub-sectors of the plurality of sub-sectors. an antenna array configured to transmit beam-steered signals in each of a plurality of sub-sectors within a sector; and a transmitter configured to cause the antenna array to transmit a sequence of primary synchronization symbols (P1, P2, P3, P4) within predetermined symbol positions in at least one slot of a subframe and to re-transmit the first transmitted primary synchronization symbol of the sequence of primary synchronization symbols within at least one symbol position followed by the said predetermined symbol positions in the at least one slot, wherein the sequence of primary synchronization symbols includes primary synchronization symbols transmitted on different sub-sectors of the plurality of sub-sectors.
A computer-implemented method comprising: storing a three-dimensional model of a patient's teeth; receiving one or more two-dimensional digital photographs of the patient's teeth taken at a time t during the course of a dental treatment; projecting, in time, the three-dimensional model of the patient's teeth to the time t, to generate and store a time-projected three-dimensional model of the patient's teeth representing an expected configuration of the patient's teeth; determining virtual camera parameters for each input two-dimensional digital photograph with respect to the projected three-dimensional model and using the determined virtual camera parameters to generate two-dimensional digital images which correspond to the two-dimensional digital photographs from the time-projected three-dimensional model of the patient's teeth, and comparing one or more of the one or more two-dimensional digital photographs of the patient's teeth to corresponding two-dimensional digital images generated from the time-projected three-dimensional model of the patient's teeth to generate one or more comparison values, from which a determination is made as to whether or not a configuration of the patient's teeth is within a threshold level of correspondence to the expected configuration of the patient's teeth. storing a three-dimensional model of a patient's teeth; receiving one or more two-dimensional digital photographs of the patient's teeth taken at a time t during the course of a dental treatment; projecting, in time, the three-dimensional model of the patient's teeth to the time t, to generate and store a time-projected three-dimensional model of the patient's teeth representing an expected configuration of the patient's teeth; determining virtual camera parameters for each input two-dimensional digital photograph with respect to the projected three-dimensional model and using the determined virtual camera parameters to generate two-dimensional digital images which correspond to the two-dimensional digital photographs from the time-projected three-dimensional model of the patient's teeth, and comparing one or more of the one or more two-dimensional digital photographs of the patient's teeth to corresponding two-dimensional digital images generated from the time-projected three-dimensional model of the patient's teeth to generate one or more comparison values, from which a determination is made as to whether or not a configuration of the patient's teeth is within a threshold level of correspondence to the expected configuration of the patient's teeth.
A terminal apparatus comprising: a measurement unit configured to measure at least one of a latency when a wireless signal is transmitted to a base station and a jitter of the wireless signal; a data processing unit configured to generate information including a result of the measurement; and a wireless signal processing unit configured to transmit the information to the base station, characterized in that the measurement unit is configured to measure at least one of the latency and the jitter for traffic identification information added to data included in the wireless signal. a measurement unit configured to measure at least one of a latency when a wireless signal is transmitted to a base station and a jitter of the wireless signal; a data processing unit configured to generate information including a result of the measurement; and a wireless signal processing unit configured to transmit the information to the base station, characterized in that the measurement unit is configured to measure at least one of the latency and the jitter for traffic identification information added to data included in the wireless signal.
A compound of the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein: each R 1 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; R 2 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; R 3 is hydrogen, C(O)R A , C(O)OR A , or alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 4 is hydrogen or alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; each R A is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; each R B is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; each R C is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; m is 1-4; each R 5 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; and n is 1-3. each R 1 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; R 2 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; R 3 is hydrogen, C(O)R A , C(O)OR A , or alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; R 4 is hydrogen or alkyl, alkyl-aryl, alkyl-heterocycle, aryl, or heterocycle; each R A is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; each R B is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; each R C is independently hydrogen or alkyl, alkyl-aryl or alkyl-heterocycle; m is 1-4; each R 5 is independently halogen, hydrogen, C(O)R A , OR A , NR B R C , S(O 2 )R A , or alkyl, alkyl-aryl or alkyl-heterocycle; and n is 1-3.
A HIP/PAP protein, or one of its derivatives thereof, for its use in the treatment or the prevention of insulin resistance in non-insulin-dependent subjects, characterized in that the said derivative comprises an amino acid sequence having a sequence identity of at least 90% with the polypeptide constituted of the amino acid sequence selected among the sequences SEQ ID NO: 1 to 4.
Sodium DNA for use in a method for the treatment of the side effects of chlorhexidine in a patient undergoing chlorhexidine treatment, wherein such side effects entail an alteration of the cell structure of the oral mucosa of said patient, said alteration of the cell structure being selected in the group consisting of: vacuolisation, degeneration of the cell nucleus, expansion of intercellular spaces.
A method for wireless communication, comprising: receiving , over a wireless channel, a message from a base station comprising an indication of a quasi-collocation, QCL, relationship between one or more port groups of a first reference signal set and each of a plurality of port groups associated with a second reference signal set; and obtaining reference signal measurements for reference signals associated with the reference signal port groups based at least in part on the indicated QCL relationships. receiving , over a wireless channel, a message from a base station comprising an indication of a quasi-collocation, QCL, relationship between one or more port groups of a first reference signal set and each of a plurality of port groups associated with a second reference signal set; and obtaining reference signal measurements for reference signals associated with the reference signal port groups based at least in part on the indicated QCL relationships.
An endoesophageal balloon for use with a transesophageal echocardiography, TEE, probe , the TEE probe comprising a TEE probe shaft , a TEE probe head , and a probe window through which ultrasound is sent and received, the balloon comprising: an inflatable body defining an internal chamber for receiving the TEE probe head; a proximal region comprising an inner surface for contacting an exterior surface along a distal section of the TEE probe shaft; an inflow tube in fluid connection with the internal chamber and extending proximally from the inflatable body; an outflow tube in fluid connection with the internal chamber and extending proximally from the inflatable body; characterized in that the endoesophageal balloon further comprises a connector to hold and create a fluid tight seal between the proximal region and the TEE probe shaft . an inflatable body defining an internal chamber for receiving the TEE probe head; a proximal region comprising an inner surface for contacting an exterior surface along a distal section of the TEE probe shaft; an inflow tube in fluid connection with the internal chamber and extending proximally from the inflatable body; an outflow tube in fluid connection with the internal chamber and extending proximally from the inflatable body; characterized in that the endoesophageal balloon further comprises a connector to hold and create a fluid tight seal between the proximal region and the TEE probe shaft .