mhurhangee/patent-ind-claim-en huggingface dataset:
An instrument configured to perform an operation, comprising: a distal end section , a proximal end section , a tube connecting the distal end section and the proximal end section and a fluid port , which comprises an inlet for the entry of flushing fluid into the interior of the instrument and at least two outlets configured to guide the flow of flushing fluid in the instrument, wherein the first outlet is configured to allow the flushing fluid to flow towards the distal end section of the instrument and the second outlet is configured to allow the flushing fluid to flow towards the proximal end of the instrument tube , characterised in that the first outlet is larger than the second outlet , wherein a push rod is provided which runs from the proximal end section to the distal end section of the instrument and flushing fluid flows in the instrument tube around the push rod and flushes around the exterior of the push rod , wherein a spring is provided in the proximal part of the push rod to actuate the push rod during an operation and the flushing fluid also flushes around this spring . a distal end section , a proximal end section , a tube connecting the distal end section and the proximal end section and a fluid port , which comprises an inlet for the entry of flushing fluid into the interior of the instrument and at least two outlets configured to guide the flow of flushing fluid in the instrument, wherein the first outlet is configured to allow the flushing fluid to flow towards the distal end section of the instrument and the second outlet is configured to allow the flushing fluid to flow towards the proximal end of the instrument tube , characterised in that the first outlet is larger than the second outlet , wherein a push rod is provided which runs from the proximal end section to the distal end section of the instrument and flushing fluid flows in the instrument tube around the push rod and flushes around the exterior of the push rod , wherein a spring is provided in the proximal part of the push rod to actuate the push rod during an operation and the flushing fluid also flushes around this spring .
A system of monitoring bay occupancy in a shelf having at least one control and evaluation unit and having at least one sensor comprising a sensor housing for monitoring bay occupancy in the shelf , wherein the sensor housing has a display device , and wherein a first light sensor having a first detection direction for detecting containers placed in a shelf bay is arranged in the sensor housing , wherein a second light sensor having a second detection device for detecting a filling status of the shelf is arranged in the sensor housing ; and wherein the sensor housing is installed in an entrance area of the shelf, the first light sensor faces into the entrance area of the shelf bay and the second light sensor faces into the shelf bay for checking the filling status, the first detection direction and the second detection direction are different, wherein the optical axes of the detection directions are arranged at an acute angle toward one another, wherein the display device is arranged at a first end of the sensor housing , wherein the first light sensor is arranged at the oppositely disposed second end of the sensor housing and the second light sensor is arranged at the second end of the sensor housing and wherein the second light sensor is a distance sensor on the basis of a time of flight measurement.
Composition comprising chlorhexidine or a salt thereof, ascorbyl glucoside and hydroxyacetophenone, wherein hydroxyacetophenone is selected among the isomeric forms para-hydroxyacetophenone, meta-hydroxyacetophenone, ortho-hydroxyacetophenone or mixtures thereof, and said composition is for topical-oral use.
A vehicle suspension, comprising an assembly of a hub carrier and a support arm , the support arm being attached to the hub carrier at two points spaced from each other in the direction of travel and extending inwardly therefrom to a support arm attachment point for fixing to a chassis, a trailing link extending from the assembly in a direction transverse to that of the support arm , toward a trailing link attachment point for fixing to the chassis, and a toe control link attached to the hub carrier at a single location which is spaced vertically from the two points and located outward of the two points , and the toe control link extending inwardly from there to a single attachment point for fixing to the chassis.
A drain valve comprising: a housing having a housing wall surrounding an axis defining a drain conduit for the passage of fluids to be drained, said drain conduit having a first rim defining an inlet to the drain conduit opposite a second rim defining an outlet; a raised strut extending radially inwardly from its radially outermost end at the first rim of the housing wall towards the axis , wherein the raised strut is angled relative to the axis such that the raised strut extends above the first rim; a post coupled to the raised strut and held within the drain conduit; a first skirt valve provided on the post and extending radially outwardly from the post toward the second rim; and a first valve seat extending from an inner surface of said housing wherein a radially distal portion of said first skirt valve sits against said first valve seat . a housing having a housing wall surrounding an axis defining a drain conduit for the passage of fluids to be drained, said drain conduit having a first rim defining an inlet to the drain conduit opposite a second rim defining an outlet; a raised strut extending radially inwardly from its radially outermost end at the first rim of the housing wall towards the axis , wherein the raised strut is angled relative to the axis such that the raised strut extends above the first rim; a post coupled to the raised strut and held within the drain conduit; a first skirt valve provided on the post and extending radially outwardly from the post toward the second rim; and a first valve seat extending from an inner surface of said housing wherein a radially distal portion of said first skirt valve sits against said first valve seat .
A dialysis system comprising: a source of water purified ; a source of concentrate for mixing with water from the water source; a disposable set including a pumping portion , a water line in fluid communication with the source of water and the pumping portion, the water line including a filter for filtering the water, a concentrate line in fluid communication with the concentrate source and the pumping portion; and a medical fluid delivery machine including a pump actuator operable with the pumping portion of the disposable set, a pressure sensor , and a control unit , characterized in that the control unit is configured to cause (i) a membrane of the filter to be wetted, (ii) the pump actuator to remove at least some of the water from the filter, (iii) a portion of the water line leading from the pumping portion to the filter to be pressurized, (iv) the pressure sensor to sense pressure in the pressurized portion of the water line, and (v) an analysis of the sensed pressure to be performed to evaluate the integrity of the filter. a source of water purified ; a source of concentrate for mixing with water from the water source; a disposable set including a pumping portion , a water line in fluid communication with the source of water and the pumping portion, the water line including a filter for filtering the water, a concentrate line in fluid communication with the concentrate source and the pumping portion; and a pumping portion , a water line in fluid communication with the source of water and the pumping portion, the water line including a filter for filtering the water, a concentrate line in fluid communication with the concentrate source and the pumping portion; and a medical fluid delivery machine including a pump actuator operable with the pumping portion of the disposable set, a pressure sensor , and a control unit , characterized in that the control unit is configured to cause (i) a membrane of the filter to be wetted, (ii) the pump actuator to remove at least some of the water from the filter, (iii) a portion of the water line leading from the pumping portion to the filter to be pressurized, (iv) the pressure sensor to sense pressure in the pressurized portion of the water line, and (v) an analysis of the sensed pressure to be performed to evaluate the integrity of the filter. a pump actuator operable with the pumping portion of the disposable set, a pressure sensor , and a control unit , characterized in that the control unit is configured to cause (i) a membrane of the filter to be wetted, (ii) the pump actuator to remove at least some of the water from the filter, (iii) a portion of the water line leading from the pumping portion to the filter to be pressurized, (iv) the pressure sensor to sense pressure in the pressurized portion of the water line, and (v) an analysis of the sensed pressure to be performed to evaluate the integrity of the filter.
A method for presenting dynamic-images to a user, the method comprising processor implemented steps of: displaying, at a given time-step (n=k ) , one or more dynamic-images to the user, wherein a dynamic-image is an image initially displayed at a specific location and moving to another location and/or an image that changes its orientation, during the given time-step (n=k ); receiving, at the given time-step ( n=k ) , the user's single response to the displayed dynamic-image/s; analyzing, the user's response/s, received at the given time-step ( n=k ), or at a given time-step (n=k) and at former time-step/s ( n<k ) , to determine a change in the user's visual acuity; and adjusting, for at least one of the following time-steps ( n>k ), one or more parameters of at least one of the dynamic-images, responsively to a predetermined threshold for- or a state of- the change. displaying, at a given time-step (n=k ) , one or more dynamic-images to the user, wherein a dynamic-image is an image initially displayed at a specific location and moving to another location and/or an image that changes its orientation, during the given time-step (n=k ); receiving, at the given time-step ( n=k ) , the user's single response to the displayed dynamic-image/s; analyzing, the user's response/s, received at the given time-step ( n=k ), or at a given time-step (n=k) and at former time-step/s ( n<k ) , to determine a change in the user's visual acuity; and adjusting, for at least one of the following time-steps ( n>k ), one or more parameters of at least one of the dynamic-images, responsively to a predetermined threshold for- or a state of- the change.
A chain element which is formed from a base material , wherein the chain element bears at least in part an outer vanadium layer which is covered by a vanadium oxide layer which forms a surface of the chain element , and characterised in that the vanadium layer on the surface of the base material has a thickness of more than 5 μm and in that the vanadium oxide layer on the surface of the vanadium layer has a thickness of less than 2 μm.
Process for expression, purification and refolding of recombinant Plasmodium vivax Duffy binding protein region II (rPvRII) having multiple cysteines useful for the prophylaxis of malarial infection in mammals, the process comprising the following steps: a) culturing the host E. coli cells containing a desired recombinant gene construct comprising a codon optimized gene sequence of rPvRII, wherein rPvRII has the structure: to produce cells in high density b) inducing expression of rPvRII in E. coli as inclusion bodies, c) harvesting the cells and isolating the said inclusion bodies, d) separating rPvRII from inclusion bodies by repeated sequential washing with washing with a buffer, the buffer used being a low salt buffer consisting of 5-50 mM Tris, 2-25 mM EDTA, 50-100 mM sodium chloride, 1-6 M urea, 0.1-1% Triton X-100, pH 6.5-7.5; followed by washing with a high salt buffer containing 5-50 mM Tris, pH 6.5-7.5 and 0.5-1 M sodium chloride; and solubilizing with chaotropic agents comprising guanidine hydrochloride at 6-8 M concentration, e) purifying the protein by subjecting to metal-chelate affinity chromatography, f) re-folding of the purified rPvRII obtained in step e) by employing a buffer containing a detergent - dextrin mixture, a co-solvent and a redox pair, wherein the detergent used is Triton X-100 at a concentration of 0.1-1.0 mM, a dextrin at a concentration of 5-20 mM, L-Arginine as a co-solvent being added in a concentration of 0.4-0.8 M and a redox pair comprising L-cysteine - cystamine dihydrochloride; followed by g) further purifying the desired protein by removing impurities by subjecting to chromatography. a) culturing the host E. coli cells containing a desired recombinant gene construct comprising a codon optimized gene sequence of rPvRII, wherein rPvRII has the structure: to produce cells in high density b) inducing expression of rPvRII in E. coli as inclusion bodies, c) harvesting the cells and isolating the said inclusion bodies, d) separating rPvRII from inclusion bodies by repeated sequential washing with washing with a buffer, the buffer used being a low salt buffer consisting of 5-50 mM Tris, 2-25 mM EDTA, 50-100 mM sodium chloride, 1-6 M urea, 0.1-1% Triton X-100, pH 6.5-7.5; followed by washing with a high salt buffer containing 5-50 mM Tris, pH 6.5-7.5 and 0.5-1 M sodium chloride; and solubilizing with chaotropic agents comprising guanidine hydrochloride at 6-8 M concentration, e) purifying the protein by subjecting to metal-chelate affinity chromatography, f) re-folding of the purified rPvRII obtained in step e) by employing a buffer containing a detergent - dextrin mixture, a co-solvent and a redox pair, wherein the detergent used is Triton X-100 at a concentration of 0.1-1.0 mM, a dextrin at a concentration of 5-20 mM, L-Arginine as a co-solvent being added in a concentration of 0.4-0.8 M and a redox pair comprising L-cysteine - cystamine dihydrochloride; followed by g) further purifying the desired protein by removing impurities by subjecting to chromatography.
An agricultural harvesting machine comprising: a binding mechanism configured to secure binding material around crop material formed into a crop package; and a delivery device configured to wrap binding material around a portion of the crop package and provide binding material to the binding mechanism ; wherein the delivery device includes a needle connected to a needle frame , the needle frame includes a yoke and a first arm ; the yoke includes a central section ; and the first arm includes a main body and a yoke receiving portion ; characterized in that the yoke further includes an upper bar extending from the central section , and a lower bar extending from the central section ; 1 and the yoke receiving portion of the first arm includes a front flange connected to the yoke and a rear flange separately coupled to the yoke . a binding mechanism configured to secure binding material around crop material formed into a crop package; and a delivery device configured to wrap binding material around a portion of the crop package and provide binding material to the binding mechanism ; wherein the delivery device includes a needle connected to a needle frame , the needle frame includes a yoke and a first arm ; the yoke includes a central section ; and the first arm includes a main body and a yoke receiving portion ; characterized in that the yoke further includes an upper bar extending from the central section , and a lower bar extending from the central section ; 1 and the yoke receiving portion of the first arm includes a front flange connected to the yoke and a rear flange separately coupled to the yoke .
A motorcycle control device configured to control a damping force of a damping device , which damps a force generated between a vehicle body of a two-wheeled vehicle and at least one of a front wheel and a rear wheel , characterized in that the motorcycle control device is configured to control the damping force based upon an angular velocity (ωd) of rotational movement in a front-rear direction of an unsprung part of the two-wheeled vehicle , which is calculated from a difference between a velocity (Vdf) in an up-down direction of the front wheel and a velocity (Vdr) in the up-down direction of the rear wheel .
An ex vivo method for the diagnosis of a disease or a risk for the development of a disease in a living being, comprising the following steps: Examination of a biological sample provided from a living being for the presence of at least one isoform of the complement factor D (isoCFD), which in comparison with CFD is extended at its N terminus by 1 to 4 amino acids, and/or in comparison with proCFD is shortened at its N terminus by 1 to 4 amino acids (isoCFD), Making a positive diagnosis in case of a positive detection of at least one isoCFD in the biological sample, or making a negative diagnosis in case of a negative detection of at least one isoCFD in the biological sample. Examination of a biological sample provided from a living being for the presence of at least one isoform of the complement factor D (isoCFD), which in comparison with CFD is extended at its N terminus by 1 to 4 amino acids, and/or in comparison with proCFD is shortened at its N terminus by 1 to 4 amino acids (isoCFD), Making a positive diagnosis in case of a positive detection of at least one isoCFD in the biological sample, or making a negative diagnosis in case of a negative detection of at least one isoCFD in the biological sample.
An apparatus for the single-track or multi-track conveying of objects along a conveying path (F) extending in a conveying direction (R), wherein the conveying path (F) for at least one track (S) comprises at least one conveying device which takes over the objects at an input side from a functional unit connected upstream and which transfers the objects at an output side to a functional unit connected downstream; and wherein the conveying device as a whole and/or in an output-side end region is adjustable transversely to the conveying direction (R) by means of an adjustment device such that the transverse position of objects to be transferred is changed within the respective track (S), characterized in that the adjustment device comprises a servomotor for adjusting the conveying device that is coupled to the conveying device , wherein the servomotor is movable together with the conveying device in the transverse direction (Q). wherein the conveying path (F) for at least one track (S) comprises at least one conveying device which takes over the objects at an input side from a functional unit connected upstream and which transfers the objects at an output side to a functional unit connected downstream; and wherein the conveying device as a whole and/or in an output-side end region is adjustable transversely to the conveying direction (R) by means of an adjustment device such that the transverse position of objects to be transferred is changed within the respective track (S), characterized in that the adjustment device comprises a servomotor for adjusting the conveying device that is coupled to the conveying device , wherein the servomotor is movable together with the conveying device in the transverse direction (Q).
A method for making a genetically modified rabbit, comprising inserting an anchor DNA sequence into an endogenous locus of a secretory milk protein gene in a rabbit embryo by introducing to the rabbit embryo a CRISPR/Cas and a sgRNA, wherein the anchor DNA sequence comprises a first site-specific recombinase recognition site; transferring the rabbit embryo to a female rabbit; and allowing said rabbit embryo to develop into an animal, wherein the sgRNA has a target sequence of: GGATATCATGTTAGAGTGCCTGG (SEQ ID NO:1). wherein the secretory milk protein gene is β-Casein, and wherein the anchor DNA sequence is inserted in intron 1 of the endogenous locus of β-Casein. inserting an anchor DNA sequence into an endogenous locus of a secretory milk protein gene in a rabbit embryo by introducing to the rabbit embryo a CRISPR/Cas and a sgRNA, wherein the anchor DNA sequence comprises a first site-specific recombinase recognition site; transferring the rabbit embryo to a female rabbit; and allowing said rabbit embryo to develop into an animal, wherein the sgRNA has a target sequence of: GGATATCATGTTAGAGTGCCTGG (SEQ ID NO:1). wherein the secretory milk protein gene is β-Casein, and wherein the anchor DNA sequence is inserted in intron 1 of the endogenous locus of β-Casein.
A monomer of formula Ia R 2 -A-R 3 Ia wherein A is a unit of formula I wherein X 1 and X 3 denote S, and X 2 and X 4 denote CH, R on each occurrence identically or differently denotes straight-chain, branched or cyclic alkyl with 1 to 35 C atoms, in which one or more non-adjacent C atoms are optionally replaced by -O-, -S-, -CO-, -CO-O-, -O-CO-,-O-CO-O-, -CR 0 =CR 00 - or -C≡C- and in which one or more H atoms are optionally replaced by F, Cl, Br, I or CN, R 0 and R 00 are independently of each other H or optionally substituted carbyl or hydrocarbyl optionally comprising one or more hetero atoms, and R 2 and R 3 are independently of each other selected from the group consisting of Cl, Br, I, O-tosylate, O-triflate, O-mesylate, O-nonaflate, -SiMe 2 F, -SiMeF 2 , -O-SO 2 Z 1 ,-B(OZ 2 ) 2 , -CZ 3 =C(Z 3 ) 2 , -C≡CH and -Sn(Z 4 ) 3 , wherein Z 1-4 are selected from the group consisting of alkyl and aryl, each being optionally substituted, and two groups Z 2 may also form a cyclic group. X 1 and X 3 denote S, and X 2 and X 4 denote CH, R on each occurrence identically or differently denotes straight-chain, branched or cyclic alkyl with 1 to 35 C atoms, in which one or more non-adjacent C atoms are optionally replaced by -O-, -S-, -CO-, -CO-O-, -O-CO-,-O-CO-O-, -CR 0 =CR 00 - or -C≡C- and in which one or more H atoms are optionally replaced by F, Cl, Br, I or CN, R 0 and R 00 are independently of each other H or optionally substituted carbyl or hydrocarbyl optionally comprising one or more hetero atoms, and R 2 and R 3 are independently of each other selected from the group consisting of Cl, Br, I, O-tosylate, O-triflate, O-mesylate, O-nonaflate, -SiMe 2 F, -SiMeF 2 , -O-SO 2 Z 1 ,-B(OZ 2 ) 2 , -CZ 3 =C(Z 3 ) 2 , -C≡CH and -Sn(Z 4 ) 3 , wherein Z 1-4 are selected from the group consisting of alkyl and aryl, each being optionally substituted, and two groups Z 2 may also form a cyclic group.
A composition comprising; a polyolefin; particles of inorganic mineral having a surface treatment including a coating of a surface treatment component, and thermal stabilizers, wherein the inorganic mineral is selected from the group consisting of talc, calcium carbonate, precipitated calcium carbonate, clay, and silica, wherein the surface treatment component is polysorbate 20 (PO-20), wherein the surface treatment component inhibits adsorption of the thermal stabilizers on the particles which allows the thermal stabilizers to remain distributed in the polyolefin and reduce degradation of the composition due to exposure to a high temperature environment. a polyolefin; particles of inorganic mineral having a surface treatment including a coating of a surface treatment component, and thermal stabilizers, wherein the inorganic mineral is selected from the group consisting of talc, calcium carbonate, precipitated calcium carbonate, clay, and silica, wherein the surface treatment component is polysorbate 20 (PO-20), wherein the surface treatment component inhibits adsorption of the thermal stabilizers on the particles which allows the thermal stabilizers to remain distributed in the polyolefin and reduce degradation of the composition due to exposure to a high temperature environment.