A chromatography medium, comprising a porous matrix; and non-porous microglobules, wherein the non-porous microglobules are covalently bonded on the inner and outer surfaces of the porous matrix, wherein the average radius of the microbglobules is not more than 30% of the average pore diameter of the porous matrix, wherein the pore diameter of the porous matrix and the radius of the microglobules is determined via scanning electron microscopy; wherein the grafting degree P of the chromatography medium is from 25% to 40%, wherein: P = m m − m 0 m 0 ∗ 100 % wherein m m is the mass of the chromatography medium and m 0 is the mass of the porous matrix without microglobules, and wherein the relative grafting degree P rel of the chromatography medium is not more than 0.25 g/cm 3 , wherein: P rel = P ∗ ρ Por wherein P is the grafting degree of the chromatography medium in %, ρ is the density of the porous matrix without microglobules in g/cm 3 , and Por is the porosity of the porous matrix without microglobules in %, wherein the non-porous microglobules are substantially spherical oligomers and/or polymers, which are constructed of at least one monomer, selected from the group consisting of glycidyl(meth)acrylate, substitued or unsubstituted alkyl(meth)acrylates and their derivatives, styrene and its derivatives, 2-vinyl-4,4-dimethylazlacton, substituted or unsubstituted N-alkyl(meth)acrylamides and their derivatives and substituted or unsubstituted N,N'-dialkyl(meth)acrylamides and their derivatives, and wherein the oligomers and/or polymers are crosslinked with one another and with the inner and outer surfaces of the porous matrix via one or more crosslinker, selected from the group consisting of ethylene glycol dimethacrylate, trimethylpropane trimethacrylate, divinylbenzene and N,N'-methylenebisacrylamide. a porous matrix; and non-porous microglobules, wherein the non-porous microglobules are covalently bonded on the inner and outer surfaces of the porous matrix, wherein the average radius of the microbglobules is not more than 30% of the average pore diameter of the porous matrix, wherein the pore diameter of the porous matrix and the radius of the microglobules is determined via scanning electron microscopy; wherein the grafting degree P of the chromatography medium is from 25% to 40%, wherein: P = m m − m 0 m 0 ∗ 100 % wherein m m is the mass of the chromatography medium and m 0 is the mass of the porous matrix without microglobules, and wherein the relative grafting degree P rel of the chromatography medium is not more than 0.25 g/cm 3 , wherein: P rel = P ∗ ρ Por wherein P is the grafting degree of the chromatography medium in %, ρ is the density of the porous matrix without microglobules in g/cm 3 , and Por is the porosity of the porous matrix without microglobules in %, wherein the non-porous microglobules are substantially spherical oligomers and/or polymers, which are constructed of at least one monomer, selected from the group consisting of glycidyl(meth)acrylate, substitued or unsubstituted alkyl(meth)acrylates and their derivatives, styrene and its derivatives, 2-vinyl-4,4-dimethylazlacton, substituted or unsubstituted N-alkyl(meth)acrylamides and their derivatives and substituted or unsubstituted N,N'-dialkyl(meth)acrylamides and their derivatives, and wherein the oligomers and/or polymers are crosslinked with one another and with the inner and outer surfaces of the porous matrix via one or more crosslinker, selected from the group consisting of ethylene glycol dimethacrylate, trimethylpropane trimethacrylate, divinylbenzene and N,N'-methylenebisacrylamide. <EOS>