An ultrasound stroke treatment system comprising: an array transducer configured to selectively produce insonation with ultrasound waves at mid/high acoustic pressure levels or with ultrasound waves at low acoustic pressure levels; and a transmit controller, coupled to control the transmission of ultrasound waves by the array transducer, wherein the transmit controller is configured to cause the array transducer to focus ultrasound waves at mid/high acoustic pressure levels to a site of an occlusion during a first therapy time interval so as to stimulate clot lysis at the site of the occlusion in the presence of vascular acoustic resonators (VARs) to cause inertial cavitation at the site of the occlusion in a first cavitation mode, wherein the transmit controller is further configured to focus or direct ultrasound waves at low acoustic pressure levels to a region surrounding the site of the occlusion during a second reperfusion stimulation time interval so as to stimulate microvascular reperfusion of tissue surrounding the site of the occlusion in the presence of vascular acoustic resonators (VARs) to cause stable cavitation in the region surrounding the site of the occlusion in a second cavitation mode, wherein the vascular acoustic resonators include gas-filled microvesicles injectable, preferably intravenously, in a microvesicle suspension, wherein a cavitation detector and monitor is provided and configured to monitor vascular acoustic resonators (VARs) oscillation in the target region, to non-invasively determine if the VARs are oscillating dominantly in their required mode and to adjust the ultrasound exposure correspondingly if they are not. an array transducer configured to selectively produce insonation with ultrasound waves at mid/high acoustic pressure levels or with ultrasound waves at low acoustic pressure levels; and a transmit controller, coupled to control the transmission of ultrasound waves by the array transducer, wherein the transmit controller is configured to cause the array transducer to focus ultrasound waves at mid/high acoustic pressure levels to a site of an occlusion during a first therapy time interval so as to stimulate clot lysis at the site of the occlusion in the presence of vascular acoustic resonators (VARs) to cause inertial cavitation at the site of the occlusion in a first cavitation mode, wherein the transmit controller is further configured to focus or direct ultrasound waves at low acoustic pressure levels to a region surrounding the site of the occlusion during a second reperfusion stimulation time interval so as to stimulate microvascular reperfusion of tissue surrounding the site of the occlusion in the presence of vascular acoustic resonators (VARs) to cause stable cavitation in the region surrounding the site of the occlusion in a second cavitation mode, wherein the vascular acoustic resonators include gas-filled microvesicles injectable, preferably intravenously, in a microvesicle suspension, wherein a cavitation detector and monitor is provided and configured to monitor vascular acoustic resonators (VARs) oscillation in the target region, to non-invasively determine if the VARs are oscillating dominantly in their required mode and to adjust the ultrasound exposure correspondingly if they are not.