A transseptal puncture system which is suitable for facilitating precise and safe transseptal puncture of a cardiac interatrial septum of a patient, comprising: a handle comprising: two twister thread half shells having internal threads; a twister bolt inner placed inside and locked into the two twister thread half shells; a nut inner placed inside the two twister thread half shells, wherein the nut inner engages with the twister bolt inner; a nut outer placed inside the two twister thread half shells, wherein the internal threads of the twister thread half shells engage with the nut outer, and wherein the nut inner and nut outer rotate in opposite directions to each other when the two twister thread half shells are turned in a direction; a first pull wire coupled to the nut inner and a second pull wire coupled to the nut outer; and a grip overmold over-molded onto the two twister thread half shells; and a transseptal insertion shaft comprising: a sheath (12, 514) that defines one or more lumens therein and has a distal end that is positioned toward the patient when the transseptal insertion shaft is in use; and at least one positioning balloon (14, 510) connected to the distal end of the sheath, wherein the at least one positioning balloon, when inflated and the transseptal insertion shaft is in use, overhangs and extends past the distal end of the sheath (12, 514), and wherein the sheath includes one or more hypotubes (516a,b) connected to the at least one positioning balloon to inflate the positioning balloon, wherein a proximal end of the transseptal insertion shaft is coupled to the handle, and a distal end of the first pull wire is attached to a first side of the transseptal insertion shaft and a distal end of the second pull wire is attached to a second side of the transseptal insertion shaft. a handle comprising: two twister thread half shells having internal threads; a twister bolt inner placed inside and locked into the two twister thread half shells; a nut inner placed inside the two twister thread half shells, wherein the nut inner engages with the twister bolt inner; a nut outer placed inside the two twister thread half shells, wherein the internal threads of the twister thread half shells engage with the nut outer, and wherein the nut inner and nut outer rotate in opposite directions to each other when the two twister thread half shells are turned in a direction; a first pull wire coupled to the nut inner and a second pull wire coupled to the nut outer; and a grip overmold over-molded onto the two twister thread half shells; a nut inner placed inside the two twister thread half shells, wherein the nut inner engages with the twister bolt inner; a nut outer placed inside the two twister thread half shells, wherein the internal threads of the twister thread half shells engage with the nut outer, and wherein the nut inner and nut outer rotate in opposite directions to each other when the two twister thread half shells are turned in a direction; a first pull wire coupled to the nut inner and a second pull wire coupled to the nut outer; and a grip overmold over-molded onto the two twister thread half shells; and a transseptal insertion shaft comprising: a sheath (12, 514) that defines one or more lumens therein and has a distal end that is positioned toward the patient when the transseptal insertion shaft is in use; and at least one positioning balloon (14, 510) connected to the distal end of the sheath, wherein the at least one positioning balloon, when inflated and the transseptal insertion shaft is in use, overhangs and extends past the distal end of the sheath (12, 514), and wherein the sheath includes one or more hypotubes (516a,b) connected to the at least one positioning balloon to inflate the positioning balloon, wherein a proximal end of the transseptal insertion shaft is coupled to the handle, and a distal end of the first pull wire is attached to a first side of the transseptal insertion shaft and a distal end of the second pull wire is attached to a second side of the transseptal insertion shaft. a sheath (12, 514) that defines one or more lumens therein and has a distal end that is positioned toward the patient when the transseptal insertion shaft is in use; and at least one positioning balloon (14, 510) connected to the distal end of the sheath, wherein the at least one positioning balloon, when inflated and the transseptal insertion shaft is in use, overhangs and extends past the distal end of the sheath (12, 514), and wherein the sheath includes one or more hypotubes (516a,b) connected to the at least one positioning balloon to inflate the positioning balloon, wherein a proximal end of the transseptal insertion shaft is coupled to the handle, and a distal end of the first pull wire is attached to a first side of the transseptal insertion shaft and a distal end of the second pull wire is attached to a second side of the transseptal insertion shaft.