A manufacturing method of a grain-oriented electrical steel sheet comprising: performing hot rolling of a slab containing, in mass%, C: 0.025% to 0.075%, Si: 2.5% to 4.0%, Mn: 0.03% to 0.30%, acid-soluble Al: 0.010% to 0.060%, N: 0.0010% to 0.0130%, Sn: 0.02% to 0.20%, S: 0.0010% to 0.020%, and P: 0.010% to 0.080%, optionally further containing at least one selected from the group consisting of, in mass%, Cr: 0.002% to 0.20%, Sb: 0.002% to 0.20%, Ni: 0.002% to 0.20%, Cu: 0.002% to 0.40%, Se: 0.0005% to 0.02%, Bi: 0.0005% to 0.02%, Pb: 0.0005% to 0.02%, B: 0.0005% to 0.02%, V: 0.002% to 0.02%, Mo: 0.002% to 0.02%, and As: 0.0005% to 0.02%, and a balance being composed of Fe and inevitable impurities to obtain a hot-rolled steel sheet; performing hot-rolled sheet annealing of the hot-rolled steel sheet to obtain an annealed steel sheet; performing cold rolling of the annealed steel sheet more than once to obtain a cold-rolled steel sheet while intermediate annealing is performed therebetween at a temperature of 750°C to 1200°C for 30 seconds to 10 minutes; performing decarburization annealing of the cold-rolled steel sheet to obtain a decarburization-annealed steel sheet in which primary recrystallization has been caused; finish annealing the decarburization-annealed steel sheet to make secondary recrystallization occur; and further performing a nitridation treatment in which an N content of the decarburization-annealed steel sheet is increased, between beginning of the decarburization annealing and occurrence of the secondary recrystallization in the finish annealing, wherein a finishing temperature in the hot rolling is 950°C or lower, the hot-rolled sheet annealing is performed at 800°C to 1200°C, a cooling rate from 750°C to 300°C in the hot-rolled sheet annealing is 10°C/second to 300°C/second, and a reduction ratio in the cold rolling is 85% or more. performing hot rolling of a slab containing, in mass%, C: 0.025% to 0.075%, Si: 2.5% to 4.0%, Mn: 0.03% to 0.30%, acid-soluble Al: 0.010% to 0.060%, N: 0.0010% to 0.0130%, Sn: 0.02% to 0.20%, S: 0.0010% to 0.020%, and P: 0.010% to 0.080%, optionally further containing at least one selected from the group consisting of, in mass%, Cr: 0.002% to 0.20%, Sb: 0.002% to 0.20%, Ni: 0.002% to 0.20%, Cu: 0.002% to 0.40%, Se: 0.0005% to 0.02%, Bi: 0.0005% to 0.02%, Pb: 0.0005% to 0.02%, B: 0.0005% to 0.02%, V: 0.002% to 0.02%, Mo: 0.002% to 0.02%, and As: 0.0005% to 0.02%, and a balance being composed of Fe and inevitable impurities to obtain a hot-rolled steel sheet; performing hot-rolled sheet annealing of the hot-rolled steel sheet to obtain an annealed steel sheet; performing cold rolling of the annealed steel sheet more than once to obtain a cold-rolled steel sheet while intermediate annealing is performed therebetween at a temperature of 750°C to 1200°C for 30 seconds to 10 minutes; performing decarburization annealing of the cold-rolled steel sheet to obtain a decarburization-annealed steel sheet in which primary recrystallization has been caused; finish annealing the decarburization-annealed steel sheet to make secondary recrystallization occur; and further performing a nitridation treatment in which an N content of the decarburization-annealed steel sheet is increased, between beginning of the decarburization annealing and occurrence of the secondary recrystallization in the finish annealing, wherein a finishing temperature in the hot rolling is 950°C or lower, the hot-rolled sheet annealing is performed at 800°C to 1200°C, a cooling rate from 750°C to 300°C in the hot-rolled sheet annealing is 10°C/second to 300°C/second, and a reduction ratio in the cold rolling is 85% or more.