A compound represented by Formula III: or a pharmaceutically acceptable salt or solvate thereof; wherein: A is aryl, aralkyl, heteroaryl, cycloalkyl, or heterocycloalkyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -N(R 4)(R 5), -CO 2 R 6, -C R 6, -CN, -C 1-4 alkylene-C 1-4 alkoxy, and -C 1-4 alkylene-N(R 4)(R 5); Y 1 and Y 2 are each independently C(R 3) or N; R 1 is hydrogen or C 1-6 alkyl; R 2 is -C -aryl, -C -aralkyl, -C -[C(R 6) 2] m -cycloalkyl, -C -[C(R 6) 2] m -heterocyclyl, -C -C 1-8 alkyl, -C -C 1-6 alkylene-C 1-6 alkoxyl, -C -C 1-6 alkylene-cycloalkyl, or -C -C 1-6 alkylene-heterocycloalkyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkyl, C 1-6 haloalkyl, -N(R 4)(R 5), -CN, -CO 2 -C 1-6 alkyl, -C -C 1-6 alkyl, -C N(R 4)(R 5), -S p C 1-6 alkyl, -SO 2 N(R 4)(R 5), and -N(R 4)SO 2 (C 1-6 alkyl); R 3 represents independently for each occurrence hydrogen, halogen, or C 1-6 alkyl; R 4 and R 5 each represent independently for each occurrence hydrogen or C 1-6 alkyl; or R 4 and R 5 taken together with the nitrogen atom to which they are attached form a 3-7 membered heterocyclic ring; R 6 represents independently for each occurrence hydrogen or C 1-6 alkyl; R 7 is hydrogen, hydroxyl, C 1-6 hydroxyalkyl, C 1-6 alkyl, C 1-6 haloalkyl, -CO 2 R 6, C 1-6 alkylene-CO 2 R 6, C 1-4 hydroxyalkylene-CO 2 R 6, -N(R 4)(R 5), C 1-6 alkylene-N(R 4)(R 5), C 1-6 hydroxyalkylene-N(R 4)(R 5), -N(R 4)C R 9, C 1-6 alkylene-N(R 4)C R 9, C 1-6 alkylene-C N(R 4)(R 5), -N(R 4)CO 2 -C 1-6 alkyl, or C 1-6 alkylene-N(R 4)(C N(R 4)(R 5); or R 7 is heterocycloalkyl or C 1-4 alkylene-heterocycloalkyl, wherein the heterocycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of oxo, halogen, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, and C 1-6 haloalkoxy; R 9 is hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkylene-N(R 4)(R 5), or C 1-6 alkylene-N(R 4)C -C 1-6 alkyl; and m and p each represent independently for each occurrence 0, 1, or 2, wherein the term "alkyl" refers to a saturated aliphatic group, including straight-chain alkyl groups, branched-chain alkyl groups, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups, and cycloalkyl substituted alkyl groups. A is aryl, aralkyl, heteroaryl, cycloalkyl, or heterocycloalkyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, -N(R 4)(R 5), -CO 2 R 6, -C R 6, -CN, -C 1-4 alkylene-C 1-4 alkoxy, and -C 1-4 alkylene-N(R 4)(R 5); Y 1 and Y 2 are each independently C(R 3) or N; R 1 is hydrogen or C 1-6 alkyl; R 2 is -C -aryl, -C -aralkyl, -C -[C(R 6) 2] m -cycloalkyl, -C -[C(R 6) 2] m -heterocyclyl, -C -C 1-8 alkyl, -C -C 1-6 alkylene-C 1-6 alkoxyl, -C -C 1-6 alkylene-cycloalkyl, or -C -C 1-6 alkylene-heterocycloalkyl; each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 alkyl, C 1-6 haloalkyl, -N(R 4)(R 5), -CN, -CO 2 -C 1-6 alkyl, -C -C 1-6 alkyl, -C N(R 4)(R 5), -S p C 1-6 alkyl, -SO 2 N(R 4)(R 5), and -N(R 4)SO 2 (C 1-6 alkyl); R 3 represents independently for each occurrence hydrogen, halogen, or C 1-6 alkyl; R 4 and R 5 each represent independently for each occurrence hydrogen or C 1-6 alkyl; or R 4 and R 5 taken together with the nitrogen atom to which they are attached form a 3-7 membered heterocyclic ring; R 6 represents independently for each occurrence hydrogen or C 1-6 alkyl; R 7 is hydrogen, hydroxyl, C 1-6 hydroxyalkyl, C 1-6 alkyl, C 1-6 haloalkyl, -CO 2 R 6, C 1-6 alkylene-CO 2 R 6, C 1-4 hydroxyalkylene-CO 2 R 6, -N(R 4)(R 5), C 1-6 alkylene-N(R 4)(R 5), C 1-6 hydroxyalkylene-N(R 4)(R 5), -N(R 4)C R 9, C 1-6 alkylene-N(R 4)C R 9, C 1-6 alkylene-C N(R 4)(R 5), -N(R 4)CO 2 -C 1-6 alkyl, or C 1-6 alkylene-N(R 4)(C N(R 4)(R 5); or R 7 is heterocycloalkyl or C 1-4 alkylene-heterocycloalkyl, wherein the heterocycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of oxo, halogen, hydroxyl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, and C 1-6 haloalkoxy; R 9 is hydrogen, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkylene-N(R 4)(R 5), or C 1-6 alkylene-N(R 4)C -C 1-6 alkyl; and m and p each represent independently for each occurrence 0, 1, or 2, wherein the term "alkyl" refers to a saturated aliphatic group, including straight-chain alkyl groups, branched-chain alkyl groups, cycloalkyl (alicyclic) groups, alkyl substituted cycloalkyl groups, and cycloalkyl substituted alkyl groups.