A device for treating a patient with obesity and/or type II diabetes comprising: - a gastric anchor movable between a first configuration sized and shaped for advancement through an esophagus into a selected region of a stomach of the patient and a second configuration sized and shaped for inhibiting distal movement of the gastric anchor through a pyloric sphincter of the patient; - a duodenal anchor (104, 230) coupled to the gastric anchor and movable between a first configuration sized and shaped for advancement through the esophagus, the stomach and the pyloric sphincter into a proximal region of a duodenum of the patient and a second configuration sized and shaped to inhibit proximal movement of the duodenal anchor through the pyloric sphincter; - a substantially hollow sleeve coupled to the duodenal anchor and sized and shaped to extend through at least a proximal portion of the duodenum of the patient; and - at least one flexible column coupling the gastric anchor to the duodenal anchor and configured for positioning across the pyloric sphincter of the patient, characterized by: - the gastric anchor being configured for inflation by a fluid from a collapsed configuration to an inflated configuration; - the duodenal anchor being configured for inflation by a fluid from a collapsed configuration to an inflated configuration, the gastric anchor comprising a ring, the ring comprising sufficiently rigid material to withstand natural peristaltic forces of the patient and remain in the second configuration, the ring being coupled to an inflatable flexible membrane, wherein a wire is incorporated into a seal of the membrane to the ring and wherein a ball is coupled to the wire and located external to the ring and the membrane, the ball being configured, upon being grasped by an endoscopic device and being pulled, to cause the wire to tear through the membrane and the seal, thus rupturing the membrane and deflating the gastric anchor; and - the flexible columns allowing both anchors to move back and forth within the stomach and the duodenum, respectively, with the natural peristalsis motion of the patient. - a gastric anchor movable between a first configuration sized and shaped for advancement through an esophagus into a selected region of a stomach of the patient and a second configuration sized and shaped for inhibiting distal movement of the gastric anchor through a pyloric sphincter of the patient; - a duodenal anchor (104, 230) coupled to the gastric anchor and movable between a first configuration sized and shaped for advancement through the esophagus, the stomach and the pyloric sphincter into a proximal region of a duodenum of the patient and a second configuration sized and shaped to inhibit proximal movement of the duodenal anchor through the pyloric sphincter; - a substantially hollow sleeve coupled to the duodenal anchor and sized and shaped to extend through at least a proximal portion of the duodenum of the patient; and - at least one flexible column coupling the gastric anchor to the duodenal anchor and configured for positioning across the pyloric sphincter of the patient, - the gastric anchor being configured for inflation by a fluid from a collapsed configuration to an inflated configuration; - the duodenal anchor being configured for inflation by a fluid from a collapsed configuration to an inflated configuration, the gastric anchor comprising a ring, the ring comprising sufficiently rigid material to withstand natural peristaltic forces of the patient and remain in the second configuration, the ring being coupled to an inflatable flexible membrane, wherein a wire is incorporated into a seal of the membrane to the ring and wherein a ball is coupled to the wire and located external to the ring and the membrane, the ball being configured, upon being grasped by an endoscopic device and being pulled, to cause the wire to tear through the membrane and the seal, thus rupturing the membrane and deflating the gastric anchor; and - the flexible columns allowing both anchors to move back and forth within the stomach and the duodenum, respectively, with the natural peristalsis motion of the patient.