A computer-implemented method for determining patient-specific cardiovascular information using at least one computer system, the method comprising: inputting into the at least one computer system patient-specific data regarding a geometry of an anatomical structure of a patient including at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta; creating, using the at least one computer system, a model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the at least a portion including a coronary vessel of the anatomical structure; creating, using the at least one computer system, a physics-based model relating to a blood flow characteristic within the anatomical structure of the patient, based on the patient-specific data; identifying at least one point of interest within the coronary vessel of the anatomical structure of the patient in the model; and determining a first blood flow rate within the anatomical structure of the patient at the at least one point of interest in the model based on a solution of the physics-based model; characterized in that the method further comprises: modifying the model by removing one or more anatomic restrictions proximal to the at least one point of interest, the one or more anatomical restrictions including one or more narrowing caused by disease; determining a second blood flow rate at a point in the modified model corresponding to the at least one point of interest in the model; and determining, using the at least one computer system, a fractional flow reserve value as a ratio of the second blood flow rate in the modified model to the first blood flow rate in the model. inputting into the at least one computer system patient-specific data regarding a geometry of an anatomical structure of a patient including at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta; creating, using the at least one computer system, a model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the at least a portion including a coronary vessel of the anatomical structure; creating, using the at least one computer system, a physics-based model relating to a blood flow characteristic within the anatomical structure of the patient, based on the patient-specific data; identifying at least one point of interest within the coronary vessel of the anatomical structure of the patient in the model; and determining a first blood flow rate within the anatomical structure of the patient at the at least one point of interest in the model based on a solution of the physics-based model; characterized in that the method further comprises: modifying the model by removing one or more anatomic restrictions proximal to the at least one point of interest, the one or more anatomical restrictions including one or more narrowing caused by disease; determining a second blood flow rate at a point in the modified model corresponding to the at least one point of interest in the model; and determining, using the at least one computer system, a fractional flow reserve value as a ratio of the second blood flow rate in the modified model to the first blood flow rate in the model. modifying the model by removing one or more anatomic restrictions proximal to the at least one point of interest, the one or more anatomical restrictions including one or more narrowing caused by disease; determining a second blood flow rate at a point in the modified model corresponding to the at least one point of interest in the model; and determining, using the at least one computer system, a fractional flow reserve value as a ratio of the second blood flow rate in the modified model to the first blood flow rate in the model.