A device useful for sampling and/or injection of a radioactive solution in a vial, wherein the vial has an opening closed by a puncturable closure member, the device comprising: a container adapted to receive said vial and a vial adaptor, said vial adaptor having a longitudinal axis, provided at a first end with a hollow spike adapted to pierce said puncturable closure member when the vial adaptor is mounted on the vial and at a second end with connection means adapted for its removable connection to a syringe adaptor, the container comprising: - a container body adapted to receive said vial, the container body having an opening, and - a vial adaptor support structure configured for being mounted onto the opening of the container body, and comprising retention means (727; 7235, 44) configured for enabling releasable retention of said vial adaptor within said vial adaptor support structure, and wherein the vial adaptor support structure and the container body are made at least partially of a radioprotective material for providing protection against ionizing radiation; wherein the vial adaptor support structure further comprises transfer means for imparting to said vial adaptor a degree of freedom in longitudinal translation along its longitudinal axis L1, relative to said container and in particular with respect to attachment means configured for enabling mounting of the vial adaptor support structure onto the opening of the container body, for this purpose, a support ring and a jacket are joined together through fastening means constituted of two assembly lugs and which pass through oblong holes formed in a tubular sleeve. wherein the jacket is configured to operating the support ring according to said degree of freedom in translation, said jacket at least partially surrounding said tubular sleeve wherein the support ring is disposed within the tubular sleeve, and adapted to support the vial adaptor, the jacket is disposed outside of said tubular sleeve adapted to maneuver the support ring. wherein the attachment means are adapted to cooperate with the corresponding engagement means of the container body. wherein lowering the assembly comprising the support ring, the jacket and the vial adaptor effects piercing of the puncturable closure member by the hollow spike of the vial adaptor. and wherein said piercing is designed optimally by the translation of the assembly comprising the support ring and the jacket on the tubular sleeve, guided by the assembly lugs, that are movable in the oblong holes. a container adapted to receive said vial and a vial adaptor, said vial adaptor having a longitudinal axis, provided at a first end with a hollow spike adapted to pierce said puncturable closure member when the vial adaptor is mounted on the vial and at a second end with connection means adapted for its removable connection to a syringe adaptor, the container comprising: - a container body adapted to receive said vial, the container body having an opening, and - a vial adaptor support structure configured for being mounted onto the opening of the container body, and comprising retention means (727; 7235, 44) configured for enabling releasable retention of said vial adaptor within said vial adaptor support structure, and - a container body adapted to receive said vial, the container body having an opening, and - a vial adaptor support structure configured for being mounted onto the opening of the container body, and comprising retention means (727; 7235, 44) configured for enabling releasable retention of said vial adaptor within said vial adaptor support structure, and wherein the vial adaptor support structure and the container body are made at least partially of a radioprotective material for providing protection against ionizing radiation; wherein the vial adaptor support structure further comprises transfer means for imparting to said vial adaptor a degree of freedom in longitudinal translation along its longitudinal axis L1, relative to said container and in particular with respect to attachment means configured for enabling mounting of the vial adaptor support structure onto the opening of the container body, for this purpose, a support ring and a jacket are joined together through fastening means constituted of two assembly lugs and which pass through oblong holes formed in a tubular sleeve. wherein the jacket is configured to operating the support ring according to said degree of freedom in translation, said jacket at least partially surrounding said tubular sleeve wherein the support ring is disposed within the tubular sleeve, and adapted to support the vial adaptor, the jacket is disposed outside of said tubular sleeve adapted to maneuver the support ring. wherein the attachment means are adapted to cooperate with the corresponding engagement means of the container body. wherein lowering the assembly comprising the support ring, the jacket and the vial adaptor effects piercing of the puncturable closure member by the hollow spike of the vial adaptor. and wherein said piercing is designed optimally by the translation of the assembly comprising the support ring and the jacket on the tubular sleeve, guided by the assembly lugs, that are movable in the oblong holes.