A system for transcatheter aortic valve treatment, comprising: an arterial access sheath adapted to be introduced into an access site at the left or right common carotid artery, or left or right subclavian artery; a valve delivery system (200, 300) configured to deliver a prosthetic valve (205, 305) into a heart or aorta through the arterial access sheath; wherein the arterial access sheath has a first lumen sized and shaped to receive the valve delivery system, the first lumen having a first opening at a proximal end of the arterial access sheath and a distal opening at a distal most end of the arterial access sheath, wherein the proximal end of the first lumen has a proximal connector with a hemostasis valve and a Y-arm, wherein the hemostasis valve is sized to fit through a valve delivery system; wherein the arterial access sheath further also has a perfusion lumen with a proximal end and a distal opening and wherein the perfusion lumen has a length such that the distal opening of the perfusion lumen can be positioned in and perfuse a distal carotid artery when in use, and wherein the proximal end of the perfusion lumen has a proximal connector; and a shunt that defines a shunt lumen arranged to fluidly connect to a source of perfusion fluid to the perfusion lumen; characterised in that: the shunt is not fluidly connected to the first lumen of the arterial access sheath; and the valve delivery system fits within the first lumen of the arterial access sheath and includes: an inner shaft; an outer sleeve co-axially aligned with the inner shaft and slidably positioned over the inner shaft; and an actuator coupled to the outer shaft, wherein the actuator can be actuated to retract the outer shaft from a first position to a second position that exposes a prosthetic aortic valve mounted on the inner shaft; wherein the valve delivery system has an entire length between 45 cm and 60 cm. an arterial access sheath adapted to be introduced into an access site at the left or right common carotid artery, or left or right subclavian artery; a valve delivery system (200, 300) configured to deliver a prosthetic valve (205, 305) into a heart or aorta through the arterial access sheath; wherein the arterial access sheath has a first lumen sized and shaped to receive the valve delivery system, the first lumen having a first opening at a proximal end of the arterial access sheath and a distal opening at a distal most end of the arterial access sheath, wherein the proximal end of the first lumen has a proximal connector with a hemostasis valve and a Y-arm, wherein the hemostasis valve is sized to fit through a valve delivery system; wherein the arterial access sheath further also has a perfusion lumen with a proximal end and a distal opening and wherein the perfusion lumen has a length such that the distal opening of the perfusion lumen can be positioned in and perfuse a distal carotid artery when in use, and wherein the proximal end of the perfusion lumen has a proximal connector; and wherein the arterial access sheath has a first lumen sized and shaped to receive the valve delivery system, the first lumen having a first opening at a proximal end of the arterial access sheath and a distal opening at a distal most end of the arterial access sheath, wherein the proximal end of the first lumen has a proximal connector with a hemostasis valve and a Y-arm, wherein the hemostasis valve is sized to fit through a valve delivery system; wherein the arterial access sheath further also has a perfusion lumen with a proximal end and a distal opening and wherein the perfusion lumen has a length such that the distal opening of the perfusion lumen can be positioned in and perfuse a distal carotid artery when in use, and wherein the proximal end of the perfusion lumen has a proximal connector; and a shunt that defines a shunt lumen arranged to fluidly connect to a source of perfusion fluid to the perfusion lumen; characterised in that: the shunt is not fluidly connected to the first lumen of the arterial access sheath; and the valve delivery system fits within the first lumen of the arterial access sheath and includes: an inner shaft; an outer sleeve co-axially aligned with the inner shaft and slidably positioned over the inner shaft; and an actuator coupled to the outer shaft, wherein the actuator can be actuated to retract the outer shaft from a first position to a second position that exposes a prosthetic aortic valve mounted on the inner shaft; wherein the valve delivery system has an entire length between 45 cm and 60 cm. the shunt is not fluidly connected to the first lumen of the arterial access sheath; and the valve delivery system fits within the first lumen of the arterial access sheath and includes: an inner shaft; an outer sleeve co-axially aligned with the inner shaft and slidably positioned over the inner shaft; and an actuator coupled to the outer shaft, wherein the actuator can be actuated to retract the outer shaft from a first position to a second position that exposes a prosthetic aortic valve mounted on the inner shaft; wherein the valve delivery system has an entire length between 45 cm and 60 cm. an inner shaft; an outer sleeve co-axially aligned with the inner shaft and slidably positioned over the inner shaft; and an actuator coupled to the outer shaft, wherein the actuator can be actuated to retract the outer shaft from a first position to a second position that exposes a prosthetic aortic valve mounted on the inner shaft; wherein the valve delivery system has an entire length between 45 cm and 60 cm.