A dialysis system comprising: a peritoneal dialysis cycler including: a cassette interface; a patient line; a drain line; a plurality of fluid storage bag lines; a fill bag line; and a cassette coupled to the cassette interface, the patient line, the drain line, the fluid storage bag lines and the fill bag line, the cassette including: a cassette housing; a plurality of channels fluidly coupled to a plurality of connectors (208a-g) each of which is coupled to a respective one of the patient line, the drain line, the fluid storage bag lines and the fill bag line; a plurality of valves (250a-m) disposed within the plurality of channels; and a single pump assembly disposed within the cassette housing, the pump assembly having: a pump housing, wherein the pump housing includes an inlet and an outlet coupled to the plurality of channels; and characterized in that the pump assembly comprises a flexible rotor including a plurality of flexible vanes, wherein the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels. a peritoneal dialysis cycler including: a cassette interface; a patient line; a drain line; a plurality of fluid storage bag lines; a fill bag line; and a cassette coupled to the cassette interface, the patient line, a cassette interface; a patient line; a drain line; a plurality of fluid storage bag lines; a fill bag line; and a cassette coupled to the cassette interface, the patient line, the drain line, the fluid storage bag lines and the fill bag line, the cassette including: a cassette housing; a plurality of channels fluidly coupled to a plurality of connectors (208a-g) each of which is coupled to a respective one of the patient line, the drain line, the fluid storage bag lines and the fill bag line; a plurality of valves (250a-m) disposed within the plurality of channels; and a single pump assembly disposed within the cassette housing, the pump assembly having: a pump housing, wherein the pump housing includes an inlet and an outlet coupled to the plurality of channels; and characterized in that the pump assembly comprises a flexible rotor including a plurality of flexible vanes, wherein the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels. a cassette housing; a plurality of channels fluidly coupled to a plurality of connectors (208a-g) each of which is coupled to a respective one of the patient line, the drain line, the fluid storage bag lines and the fill bag line; a plurality of valves (250a-m) disposed within the plurality of channels; and a single pump assembly disposed within the cassette housing, the pump assembly having: a pump housing, wherein the pump housing includes an inlet and an outlet coupled to the plurality of channels; and characterized in that the pump assembly comprises a flexible rotor including a plurality of flexible vanes, wherein the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels. a pump housing, wherein the pump housing includes an inlet and an outlet coupled to the plurality of channels; and characterized in that the pump assembly comprises a flexible rotor including a plurality of flexible vanes, wherein the flexible rotor is rotatable in either a clockwise direction or a counterclockwise direction to move a fluid through the plurality of channels.