A compound of Formula II: or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or stereoisomer thereof wherein: L 1 is straight or branched C 1 -C 5 alkyl optionally substituted with one or more substituents selected from the group consisting of H, OH, OR 10, NHR 10, and N(R 10)(R 10') provided that no more than one oxygen or nitrogen is attached to any carbon; or L 1 is selected from the group consisting of -C -, -C -C 1 -C 3 alkylenyl-, -S 2 -, - S 2 NH-, -CON(R 10)-, and a bond; each R 10 and R 10' is independently selected from the group consisting of C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, OPO 3 -2 M 2, OP 2, OCOalkyl, and OC Oalkyl where M is a monovalent metal cation; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl provided that no more than one oxygen is attached to any carbon; or R 10 and R 10', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is aryl or heteroaryl, both of which optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, O-R 10, OPO 3 -2 M 2, OP 2, SH, S-R 10, C 1 -C 5 alkyl, branched alkyl, NH 2, NHR 10, N(R 10)(R 10') and NHCOR 10 where M is a monovalent metal cation; or R 1 is cycloalkyl; Y and Y' are independently H, F or methyl; L 2 is a bond, (CH 2) n or (CHR 11) n; each R 11 is independently selected from the group consisting of H, -C 1 -C 5 alkylenyl-, -CO-C 1 -C 5 alkylenyl-, and -alkylenyl-CO-alkylenyl-; R 2 is phenyl, naphthyl, heteroaryl or bicyclic heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, OR 10, CN, NH 2, NHR 10, N(R 10)(R 10'), SH, SR 10, -S R 10, -S 2 R 10, -S 2 NHR 10, - S 2 N(R 10)(R 10'), -C NH 2, -C NR 10, and -C N(R 10)(R 10'); and n is 1, 2, or 3; with the exception of the following compounds: L 1 is straight or branched C 1 -C 5 alkyl optionally substituted with one or more substituents selected from the group consisting of H, OH, OR 10, NHR 10, and N(R 10)(R 10') provided that no more than one oxygen or nitrogen is attached to any carbon; or L 1 is selected from the group consisting of -C -, -C -C 1 -C 3 alkylenyl-, -S 2 -, - S 2 NH-, -CON(R 10)-, and a bond; each R 10 and R 10' is independently selected from the group consisting of C 1 -C 6 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, O-C 1 -C 5 alkyl, OPO 3 -2 M 2, OP 2, OCOalkyl, and OC Oalkyl where M is a monovalent metal cation; and cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and O-C 1 -C 5 alkyl provided that no more than one oxygen is attached to any carbon; or R 10 and R 10', together with the nitrogen to which they are attached, may form a heterocycle; R 1 is aryl or heteroaryl, both of which optionally substituted with one or more substituents selected from the group consisting of OH, CN, halogen, O-R 10, OPO 3 -2 M 2, OP 2, SH, S-R 10, C 1 -C 5 alkyl, branched alkyl, NH 2, NHR 10, N(R 10)(R 10') and NHCOR 10 where M is a monovalent metal cation; or R 1 is cycloalkyl; Y and Y' are independently H, F or methyl; L 2 is a bond, (CH 2) n or (CHR 11) n; each R 11 is independently selected from the group consisting of H, -C 1 -C 5 alkylenyl-, -CO-C 1 -C 5 alkylenyl-, and -alkylenyl-CO-alkylenyl-; R 2 is phenyl, naphthyl, heteroaryl or bicyclic heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, OH, OR 10, CN, NH 2, NHR 10, N(R 10)(R 10'), SH, SR 10, -S R 10, -S 2 R 10, -S 2 NHR 10, - S 2 N(R 10)(R 10'), -C NH 2, -C NR 10, and -C N(R 10)(R 10'); and n is 1, 2, or 3; with the exception of the following compounds: