A process for the manufacture of a supramolecular biomedical polymer having an ultimate tensile strength of at least 35 MPa, as determined by test method ASTM D 1708-96 with a crosshead speed of 20 mm/min, said process comprising reacting a compound F' according to Formula: with: a diisocyanate compound C' according to the Formula O=C=N-R 3 -N=C=O, wherein diisocyanate compound C' is preferably selected from the group consisting of 1,4-diisocyanatobutane, 1,6-diisocyanatohexane and 1,12-diisocyanatododecane, wherein diisocyanate compound C' more preferably is 1,6-diisocyanatohexane; a functionalized polymer A' according to the Formula P- w; and a compound B' according to the Formula FG2-R 4 -FG3, wherein compound B' is preferably selected from the group consisting of 1,4-butanediol, 1,12-dodecyldiol and 1,6-hexanediol, wherein compound B' more preferably is 1,6-hexanediol; wherein: X is O or S; k is an integer of 1 to 20; n is an integer of 0 to 8; R 1 is a C 1 - C 13 alkyl group; R 2 is a functional group selected from OH, SH and NH 2; FG1, FG2 and FG3 are functional groups independently selected from OH and NH 2; w is in the range of about 1.8 to about 2; functionalized polymer A' has a number average molecular weight M n, as determined from its hydroxyl value, of about 1000 to about 2000 Da; P is a polymer, with the proviso that it is neither poly(ethyleneglycol) nor polycaprolactone; functionalized polymer A' is selected from FG1-functionalized polycarbonate, poly(tetramethylene glycol), and FG1-functionalized hydrogenated polybutadiene; R 3 is a linear C 4 - C 20 alkylene group; R 4 is a linear C 2 - C 20 alkylene group; and wherein the molar ratio of compounds A', B', C' and F' expressed as A':B':C':F' is between 1:1.5:3.5:1 and 1:2:4:1. a diisocyanate compound C' according to the Formula O=C=N-R 3 -N=C=O, wherein diisocyanate compound C' is preferably selected from the group consisting of 1,4-diisocyanatobutane, 1,6-diisocyanatohexane and 1,12-diisocyanatododecane, wherein diisocyanate compound C' more preferably is 1,6-diisocyanatohexane; a functionalized polymer A' according to the Formula P- w; and a compound B' according to the Formula FG2-R 4 -FG3, wherein compound B' is preferably selected from the group consisting of 1,4-butanediol, 1,12-dodecyldiol and 1,6-hexanediol, wherein compound B' more preferably is 1,6-hexanediol; wherein: X is O or S; k is an integer of 1 to 20; n is an integer of 0 to 8; R 1 is a C 1 - C 13 alkyl group; R 2 is a functional group selected from OH, SH and NH 2; FG1, FG2 and FG3 are functional groups independently selected from OH and NH 2; w is in the range of about 1.8 to about 2; functionalized polymer A' has a number average molecular weight M n, as determined from its hydroxyl value, of about 1000 to about 2000 Da; P is a polymer, with the proviso that it is neither poly(ethyleneglycol) nor polycaprolactone; functionalized polymer A' is selected from FG1-functionalized polycarbonate, poly(tetramethylene glycol), and FG1-functionalized hydrogenated polybutadiene; R 3 is a linear C 4 - C 20 alkylene group; R 4 is a linear C 2 - C 20 alkylene group; and wherein the molar ratio of compounds A', B', C' and F' expressed as A':B':C':F' is between 1:1.5:3.5:1 and 1:2:4:1. X is O or S; k is an integer of 1 to 20; n is an integer of 0 to 8; R 1 is a C 1 - C 13 alkyl group; R 2 is a functional group selected from OH, SH and NH 2; FG1, FG2 and FG3 are functional groups independently selected from OH and NH 2; w is in the range of about 1.8 to about 2; functionalized polymer A' has a number average molecular weight M n, as determined from its hydroxyl value, of about 1000 to about 2000 Da; P is a polymer, with the proviso that it is neither poly(ethyleneglycol) nor polycaprolactone; functionalized polymer A' is selected from FG1-functionalized polycarbonate, poly(tetramethylene glycol), and FG1-functionalized hydrogenated polybutadiene; R 3 is a linear C 4 - C 20 alkylene group; R 4 is a linear C 2 - C 20 alkylene group; and wherein the molar ratio of compounds A', B', C' and F' expressed as A':B':C':F' is between 1:1.5:3.5:1 and 1:2:4:1.