An inhibitor of Histamine type 4 receptor (H4R) for use in the treatment of tinnitus, wherein said inhibitor of H4R is selected from: - 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, - 4-( -3-aminopyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine, - cis-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h] quinazolin-2-amine, - 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine, - 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2 -yl)-2-cyclopentylethanone, - 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate, - N 4 -(cyclopropylmethyl)-6-[ -3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine, - N 4 -(cyclopropylmethyl)-6-[ -3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine tartrate, - -4-(3-amino-pyrrolidin-1-y1)-6-isopropyl-pyrimidin-2-ylamine, - 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-isobutyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexylmethyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(4-fluorobenzyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopropyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-tert-butyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-isopropyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-(cyclopropylmethyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 6-(3-(methylamino)azetidin-1-yl)-2-(phenoxymethyl)pyrimidin-4-amine, - 2-cyclopropyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-tert-butyl-6-( -3-(methylamino)pyrrolidin-1-y1)pyrimidin-4-amine, - 2-isopropyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 6-( -3-(methylamino)pyrrolidin-1-yl)-2-(phenoxymethyl)pyrimidin-4-amine, - 6-(3-aminoazetidin-1-yl)-2-isobutylpyrimidin-4-amine, - 2-isobutyl-6-(3-methyl-3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 6-( -3-aminopyrrolidin-1-yl)-2-isobutylpyrimidin-4-amine, - 2-cyclobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclobutyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclopentyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopentyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(2,2-dimethylpropyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-(2,2-dimethylpropyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(2-cyclopentylethyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexylmethyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopropylmethyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclohexyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, and - 2-(4-fluorobenzyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine. - 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, - 4-( -3-aminopyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine, - cis-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h] quinazolin-2-amine, - 7-(furan-2-yl)-4-(piperazin-1-yl)quinazolin-2-amine, - 1-(7-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)-3,4-dihydroisoquinolin-2 -yl)-2-cyclopentylethanone, - 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate, - N 4 -(cyclopropylmethyl)-6-[ -3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine, - N 4 -(cyclopropylmethyl)-6-[ -3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine tartrate, - -4-(3-amino-pyrrolidin-1-y1)-6-isopropyl-pyrimidin-2-ylamine, - 2-isobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-isobutyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexylmethyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(4-fluorobenzyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopropyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-tert-butyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-isopropyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-(cyclopropylmethyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 6-(3-(methylamino)azetidin-1-yl)-2-(phenoxymethyl)pyrimidin-4-amine, - 2-cyclopropyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-tert-butyl-6-( -3-(methylamino)pyrrolidin-1-y1)pyrimidin-4-amine, - 2-isopropyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 6-( -3-(methylamino)pyrrolidin-1-yl)-2-(phenoxymethyl)pyrimidin-4-amine, - 6-(3-aminoazetidin-1-yl)-2-isobutylpyrimidin-4-amine, - 2-isobutyl-6-(3-methyl-3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 6-( -3-aminopyrrolidin-1-yl)-2-isobutylpyrimidin-4-amine, - 2-cyclobutyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclobutyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclopentyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopentyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(2,2-dimethylpropyl)-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-(2,2-dimethylpropyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-(2-cyclopentylethyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexylmethyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclopropylmethyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, - 2-cyclohexyl-6-(3-(methylamino)azetidin-1-yl)pyrimidin-4-amine, - 2-cyclohexyl-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine, and - 2-(4-fluorobenzyl)-6-( -3-(methylamino)pyrrolidin-1-yl)pyrimidin-4-amine.