mhurhangee/ep-ind-claims huggingface dataset:
A recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a nucleic acid sequence encoding a mutant polypeptide having malate dehydrogenase activity, wherein the mutant polypeptide comprises an amino acid sequence which, when aligned with the malate dehydrogenase comprising the sequence set out in SEQ ID NO: 39, comprises a mutation of an amino acid residue corresponding to amino acid 34 in SEQ ID NO: 39, wherein the recombinant host cell is a fungal cell, wherein the nucleic sequence encoding the mutant polypeptide having malate dehydrogenase activity is expressed in the cytosol and the mutant polypeptide having malate dehydrogenase activity is active in the cytosol, and wherein the mutant polypeptide having malate dehydrogenase activity has at least 70% sequence identity with SEQ ID NO: 39 or SEQ ID NO: 53, and wherein the recombinant host cell produces an increased amount of a dicarboxylic acid in comparison to a recombinant host cell expressing the malate dehydrogenase polypeptide of SEQ ID NO: 39. wherein the recombinant host cell is a fungal cell, wherein the nucleic sequence encoding the mutant polypeptide having malate dehydrogenase activity is expressed in the cytosol and the mutant polypeptide having malate dehydrogenase activity is active in the cytosol, and wherein the mutant polypeptide having malate dehydrogenase activity has at least 70% sequence identity with SEQ ID NO: 39 or SEQ ID NO: 53, and wherein the recombinant host cell produces an increased amount of a dicarboxylic acid in comparison to a recombinant host cell expressing the malate dehydrogenase polypeptide of SEQ ID NO: 39.
A graft polymer of polysaccharides and polypeptides or its respective derivatives, whereas the derivatives of the polysaccharides are oxidatively, hydrolytically or enzymatically degraded polysaccharides, oxidized hydrolytically degraded or oxidized enzymatically degraded polysaccharides, or such chemically modified degraded products or chemically modified mono-, oligo-or polysaccharides and whereas the derivatives of the polypeptides are hydrolytically or enzymatically degraded and optionally chemically modified polypeptides, obtainable by free radical polymerization of A) a monomer selected from or a monomer mixture of (a) from 20 to 100% by weight of acrylic acid or methacrylic acid or of a mixture thereof or of the alkali metal, alkaline earth metal or ammonium salts thereof, (b) from 0 to 80 % by weight of other monoethylenically unsaturated monomers which are copolymerizable with the monomer (a) and (c) from 0 to 5% by weight of monomers having at least 2 ethylenically unsaturated, nonconjugated double bonds in the molecule, in the presence of B1) polysaccharides, oxidatively, hydrolytically or enzymatically degraded polysaccharides, oxidized hydrolytically degraded or oxidized enzymatically degraded polysaccharides, or such chemically modified degraded products, chemically modified mono-, oligo-or polysaccharides or mixtures of the stated compounds and B2) polypeptides, hydrolytically or enzymatically degraded and optionally chemically modified polypeptides or mixtures of the stated compounds in a weight ratio A:(B1 + B2) of from 60:40 to 1:99 and B1: B2 of from 97:3 to 3:97. A) a monomer selected from or a monomer mixture of (a) from 20 to 100% by weight of acrylic acid or methacrylic acid or of a mixture thereof or of the alkali metal, alkaline earth metal or ammonium salts thereof, (b) from 0 to 80 % by weight of other monoethylenically unsaturated monomers which are copolymerizable with the monomer (a) and (c) from 0 to 5% by weight of monomers having at least 2 ethylenically unsaturated, nonconjugated double bonds in the molecule, (a) from 20 to 100% by weight of acrylic acid or methacrylic acid or of a mixture thereof or of the alkali metal, alkaline earth metal or ammonium salts thereof, (b) from 0 to 80 % by weight of other monoethylenically unsaturated monomers which are copolymerizable with the monomer (a) and (c) from 0 to 5% by weight of monomers having at least 2 ethylenically unsaturated, nonconjugated double bonds in the molecule, B1) polysaccharides, oxidatively, hydrolytically or enzymatically degraded polysaccharides, oxidized hydrolytically degraded or oxidized enzymatically degraded polysaccharides, or such chemically modified degraded products, chemically modified mono-, oligo-or polysaccharides or mixtures of the stated compounds and B2) polypeptides, hydrolytically or enzymatically degraded and optionally chemically modified polypeptides or mixtures of the stated compounds
A heat alarm apparatus comprising a heat sensing module, the heat sensing module comprising: a housing defining a body; a sensor mounting panel (22, 222) having a concave reflective surface, the sensor mounting panel being recessed within the housing; a heat sensor extending from the sensor mounting panel (22, 222); protection means protecting the heat sensor from damage and located around the heat sensor in a manner that allows free flow of air past the sensor; and a control circuit configured to detect a temperature rise at the heat sensor and output an alarm signal in response thereto; wherein a sensing part of the heat sensor is located in a space formed between the concave surface of the sensor mounting panel (22, 222) and the protection means, and, the heat sensor is located substantially central with respect to the sensor mounting panel (22, 222) in order that heat reflected by the concave reflective surface of the sensor mounting panel (22, 222) is reflected in the direction of the heat sensor. a housing defining a body; a sensor mounting panel (22, 222) having a concave reflective surface, the sensor mounting panel being recessed within the housing; a heat sensor extending from the sensor mounting panel (22, 222); protection means protecting the heat sensor from damage and located around the heat sensor in a manner that allows free flow of air past the sensor; and a control circuit configured to detect a temperature rise at the heat sensor and output an alarm signal in response thereto; wherein a sensing part of the heat sensor is located in a space formed between the concave surface of the sensor mounting panel (22, 222) and the protection means, and, the heat sensor is located substantially central with respect to the sensor mounting panel (22, 222) in order that heat reflected by the concave reflective surface of the sensor mounting panel (22, 222) is reflected in the direction of the heat sensor.
A compound having the formula: wherein: W is a bond,-C -O- or -S 2 -; X is phenyl, which can be optionally substituted with up to 2 groups, which can be the same or different, and are selected from halo, -CN and -S 2 -alkyl; Y is: Z is a bond, -CH 2 -, -O- or -S 2 -; R 3 is alkyl, cycloalkyl or heteroaryl, wherein a cycloalkyl or heteroaryl group can be unsubstituted or optionally substituted with an alkyl or halo group; R 17 is H or alkyl; p is 0 or 1; q is 0 or 1; r is 0 or 1; s is 0 or 1; and u is 0 or 1 or a pharmaceutically acceptable salt or solvate thereof. W is a bond,-C -O- or -S 2 -; X is phenyl, which can be optionally substituted with up to 2 groups, which can be the same or different, and are selected from halo, -CN and -S 2 -alkyl; Y is: Z is a bond, -CH 2 -, -O- or -S 2 -; R 3 is alkyl, cycloalkyl or heteroaryl, wherein a cycloalkyl or heteroaryl group can be unsubstituted or optionally substituted with an alkyl or halo group; R 17 is H or alkyl; p is 0 or 1; q is 0 or 1; r is 0 or 1; s is 0 or 1; and u is 0 or 1 or a pharmaceutically acceptable salt or solvate thereof.
Navigation device with an operating unit, by means of which at least alphanumerical characters and/or symbols can be selected and combined to form a character or function group, and with a display device by means of which using a display unit, selectable characters and/or symbols can be displayed in at least one selection field and selected characters, symbols, character or function groups can be displayed in at least one input field, with a storage device with data stored therein, and with a data processing unit for selecting data from data stored in the storage device, on the basis of predeterminable criteria and taking into consideration the characters and/or symbols selected so far by a user, characterised in that the device is set up to display on the display unit a completion designation in the form of a cursor, a horizontal line, a marking and/or frame in the area of the selection field in the immediate vicinity of a character or symbol selected most recently by a user and displayed in the selection field, provided that a possible completion of the character(s) and/or symbol(s) selected so far is determined by the data processing unit on the basis of the data in the storage device and taking into consideration the character(s) and/or symbol(s) selected by a user so far, the completion designation can be selected by a user using the operating unit or a selection designation can be positioned automatically on the completion designation, a displayed completion suggestion can be selected by a user using the operating unit, and in the case where the completion designation is selected by a user using the operating unit or a selection designation is automatically positioned on the completion designation, in addition to the completion designation at least one completion suggestion is displayed automatically in the area of the input field, wherein an additional graphic element is displayed, which extends from the area of the displayed completion designation to the area of the at least one completion suggestion.
A method for operating a hydraulically operated handheld device, for example a pressing device and/or a hole-punching or punching device, wherein the handheld device comprises a hydraulic pump, a moving part, a fixed part and a return valve with an associated valve seat, wherein the moving part is moved into a working position due to the buildup of a hydraulic pressure, which is realized by filling a hydraulic chamber with hydraulic medium from a reservoir with the aid of the hydraulic pump, and wherein the moving part can be automatically moved back from the working position into an end position upon reaching a predefined working pressure by opening the return valve, characterized in that the hydraulic pressure acting upon the return valve for triggering a movement of the moving part into the end position is increased by means of a separately triggerable pressure increase, which results in opening of the return valve, in a hydraulic medium volume located upstream of the return valve in a flow direction of the hydraulic medium during the movement into the end position.
Method of producing multi-leaf, folded printed products, in particular periodicals and brochures, based on a material web which is printed in a digital printing station and has at least three printed material-web portions (2, 3, 4) arranged one beside the other in its longitudinal direction, characterized in that, while the material web is moved in an advancement direction, a first material-web strand, which is formed by at least one printed material-web portion, is combined with a second material-web strand, which is formed by two printed material-web portions (2, 3), and is connected to the second material-web strand by means of an adhesive along a connecting line running in the longitudinal direction of the material web, in that subproducts are severed from the interconnected first and second material-web strands (10, 11) by cutting transversely to the advancement direction of the material web, these subproducts consisting of a first printed sheet, severed from the first material-web strand, and a second printed sheet, connected to the first printed sheet and severed from the second material-web strand, and then being stacked to form a stack, in that the subproducts are connected to one another during stacking or following stacking, and in that the subproducts are folded as a stack about a folding line which runs between the adjacent printed portions of the second printed sheet.
A peptide, comprising an amino acid sequence which is at least 60% identical to the amino acid sequence SEQ ID NO: 1, and further comprising at least one macrocycle-forming linker connecting a first amino acid to a second amino acid of said sequence wherein the sequence consists of: LKX 1 QAX 2 X 3 YK X 4 RFX 5 X 6 X 7 R X 8 ARX 9 K (SEQ ID NO: 2), in which: X 1 is A or a cross-linked amino acid; X 2 is D, a cross-linked amino acid or a neutral amino acid; X 3 is I or a cross-linked amino acid; X 4 is A or a cross-linked amino acid; X 5 is Q or a cross-linked amino acid; X 6 is A or a cross-linked amino acid; X 7 is E or a neutral or basic amino acid; X 8 is H or Q; and X 9 is E or a neutral or basic amino acid; providing that one pair of amino acids chosen from X 1 and X 3, X 1 and X 4, X 2 and X 4, X 2 and X 5, and X 4 and X 6 is cross-linked by the macrocycle-forming linker. X 1 is A or a cross-linked amino acid; X 2 is D, a cross-linked amino acid or a neutral amino acid; X 3 is I or a cross-linked amino acid; X 4 is A or a cross-linked amino acid; X 5 is Q or a cross-linked amino acid; X 6 is A or a cross-linked amino acid; X 7 is E or a neutral or basic amino acid; X 8 is H or Q; and X 9 is E or a neutral or basic amino acid;
A method for managing control information for a wireless transmit/receive unit, WTRU,'the method comprising: reporting, by the WTRU to a network entity, a plurality of codebook values representing a plurality of precoding matrices, as feedback; receiving a message including a single bit indicator contained in a first field and a single codebook value contained in a second field, the single codebook value contained in the second field representing one of the plurality of precoding matrices or another precoding matrix; processing at least the single bit indicator, the single bit indicator indicating which of the single codebook value or the plurality of codebook values is to be used by the WTRU; and applying, to information received or to be transmitted by the WTRU, preceding in accordance with the indicated single codebook value or the indicated plurality of codebook values. reporting, by the WTRU to a network entity, a plurality of codebook values representing a plurality of precoding matrices, as feedback; receiving a message including a single bit indicator contained in a first field and a single codebook value contained in a second field, the single codebook value contained in the second field representing one of the plurality of precoding matrices or another precoding matrix; processing at least the single bit indicator, the single bit indicator indicating which of the single codebook value or the plurality of codebook values is to be used by the WTRU; and applying, to information received or to be transmitted by the WTRU, preceding in accordance with the indicated single codebook value or the indicated plurality of codebook values.
A method for decoding a codeword, comprising: transmitting, via a transmitter device, at least a portion of a composite code mask projected onto the surface of a target object, the composite code mask defined by a code layer of uniquely identifiable spatially-coded codewords defined by a plurality of symbols, and a carrier layer independently ascertainable and distinct from the code layer and including a plurality of reference objects that are robust to distortion upon projection; obtaining, via a receiver sensor, at least a portion of the composite code mask reflected from the surface of the target object; and adjusting, at a processing circuit, the code layer for distortion based on the reference objects within the portion of the composite code mask; characterized in that at least one of the code layer and carrier layer has been pre-shaped by a synthetic point spread function prior to projection. transmitting, via a transmitter device, at least a portion of a composite code mask projected onto the surface of a target object, the composite code mask defined by a code layer of uniquely identifiable spatially-coded codewords defined by a plurality of symbols, and a carrier layer independently ascertainable and distinct from the code layer and including a plurality of reference objects that are robust to distortion upon projection; a code layer of uniquely identifiable spatially-coded codewords defined by a plurality of symbols, and a carrier layer independently ascertainable and distinct from the code layer and including a plurality of reference objects that are robust to distortion upon projection; obtaining, via a receiver sensor, at least a portion of the composite code mask reflected from the surface of the target object; and adjusting, at a processing circuit, the code layer for distortion based on the reference objects within the portion of the composite code mask; characterized in that at least one of the code layer and carrier layer has been pre-shaped by a synthetic point spread function prior to projection.
Transverse segment for a drive belt with an endless carrier and with a number of such transverse segments, slidably arranged on the endless carrier, which transverse segment is provided with two main body surfaces (38, 39), where between the transverse segment extends in thickness direction and whereof a first main body surface is provided with a convexly curved tilting edge, which tilting edge provides a transition in height direction between an upper part of the transverse segment with an essentially constant thickness (Tts) and a lower part of the transverse segment, whereof the thickness reduces in a direction away from the tilting edge, and which tilting edge serves to allow two adjacent transverse segments in the drive belt to mutually tilt or rotate while remaining in pushing contact with one another in the drive belt by a flat section of a second main body surface of the two main body surfaces (38, 39) of one of the two adjacent transverse segment rolling-off on the convex curvature of the tilting edge of the said first main body surface of the other one of the two adjacent transverse segments, which transverse segment is further provided with at least one cut-out that extends in-between the two main body surfaces (38, 39) and that in downward direction is bounded by a bearing surface supporting the inside of the endless carrier, characterized in that an upper extend of the tilting edge is located above the bearing surface and in that a lower extend of the tilting edge is located below the bearing surface.
An aerodynamic structure for an aircraft, the aerodynamic structure comprising a first region having a first magnetic sealing surface, movably connected to a second region having a second magnetic sealing surface, the first and second magnetic sealing surfaces (111, 121) being configured such that an attractive magnetic force exists between the first and second magnetic sealing surfaces (111, 121) when the aerodynamic structure is in a first configuration in which the first sealing surface contacts the second sealing surface such that the first region and the second region form a continuous aerodynamic surface; characterized in that the aerodynamic structure is moveable between the first configuration and a second configuration in which a gap exists between the first sealing surface and the second sealing surface; and wherein the aerodynamic structure is configured such that during movement between the first configuration and the second configuration, relative movement of the first and second regions (11, 12) occurs along a direction at an angle in the range 1-90° to the normal of the first sealing surface and/or the normal of the second sealing surface. characterized in that the aerodynamic structure is moveable between the first configuration and a second configuration in which a gap exists between the first sealing surface and the second sealing surface; and wherein the aerodynamic structure is configured such that during movement between the first configuration and the second configuration, relative movement of the first and second regions (11, 12) occurs along a direction at an angle in the range 1-90° to the normal of the first sealing surface and/or the normal of the second sealing surface.
Fastening system for fastening a driven profile portion of a tool to a drive profile portion of a hand-held power tool, which drive profile portion can be brought into an oscillating rotational movement about an axis of rotation by a motor, wherein the drive profile portion has entraining projections which are arranged so as to have a uniform angular distribution on a circular-arc line about the axis of rotation and protrude axially from a support region, wherein the driven profile portion has a window having an edge and having recesses which are arranged in a region adjoining the edge and are intended for the entry of the entraining projections, and is in the form of a flat piece, with a first broad side which rests on the support region and a second broad side opposite thereto, which second broad side is acted upon in the axial direction by a clamping flank of a clamping head arranged eccentrically to the axis of rotation, wherein an outer edge of an adapter element rests against the second broad side, wherein the inner edge is acted upon by the clamping flank over only a maximum of half its circumferential length, and the clamping head can be pushed through an opening surrounded by the inner edge.
A method of predicting whether a male subject has an increased risk of developing cancer, comprising: determining a fraction of cells from a biological sample obtained from said male subject that have lost chromosome Y; comparing said fraction to a predefined threshold; and predicting whether said male subject has an increased risk of developing cancer based on said comparison between said fraction and said predefined threshold; wherein: said male subject has an increased risk of developing cancer if said fraction is equal to or higher than said predefined threshold; or said male subject does not have any increased risk of developing cancer if said fraction is lower than said predefined threshold. determining a fraction of cells from a biological sample obtained from said male subject that have lost chromosome Y; comparing said fraction to a predefined threshold; and predicting whether said male subject has an increased risk of developing cancer based on said comparison between said fraction and said predefined threshold; wherein: said male subject has an increased risk of developing cancer if said fraction is equal to or higher than said predefined threshold; or said male subject does not have any increased risk of developing cancer if said fraction is lower than said predefined threshold. said male subject has an increased risk of developing cancer if said fraction is equal to or higher than said predefined threshold; or said male subject does not have any increased risk of developing cancer if said fraction is lower than said predefined threshold.
A composition for fixing wound items comprising A) 5 to 80 wt% of at least one polyolefin-containing unsaturated polyester resin, B) 0 to 60 wt% of at least one unsaturated polyester resin different from A), C) 5 to 70 wt% of at least one reactive diluent, D) 0.01 to 15 wt% of additives, and E) 0.1 to 20 wt% of at least one free radical initiator, the wt% being based on the total weight of the composition, wherein the at least one polyolefin-containing unsaturated polyester resin A) is obtained by reaction of at least one functional polyolefin with at least one polybasic carboxylic acid, acid anhydride and/or ester therefrom, and polyhydric alcohols and further reaction of the resulted product with at least one carbon-carbon unsaturated functional compound. A) 5 to 80 wt% of at least one polyolefin-containing unsaturated polyester resin, B) 0 to 60 wt% of at least one unsaturated polyester resin different from A), C) 5 to 70 wt% of at least one reactive diluent, D) 0.01 to 15 wt% of additives, and E) 0.1 to 20 wt% of at least one free radical initiator,