A hand-held test meter for use with an electro-chemical-based analytical test strip in the determination of an analyte in a bodily fluid sample, the hand-held test meter comprising: a housing; a strip port connector disposed at least partially within the housing and configured to receive an electro-chemical based analytical test strip; a micro-controller disposed in the housing and configured to generate a micro-controller command signal, the micro-controller comprising an analogue-to-digital converter input; an electrode bias drive circuit block disposed in the housing and configured to generate a bias drive signal based on the micro-controller command signal; an automatic bias drive adjustment circuit block disposed in the housing and configured to receive at least one sensed electrode voltage and to adjust a bias drive signal from the electrode bias drive circuit block based on the at least one sensed electrode voltage to create an adjusted bias drive signal, wherein the automatic bias drive adjustment circuit block comprises: a first difference amplifier configured to provide the at least one sensed electrode voltage; an error amplifier configured to compare the at least one sensed electrode voltage to the generated bias drive signal; a trans-impedance amplifier configured to use the output of the error amplifier to both drive the adjusted bias drive signal and to measure at least one sensed electrode current; a resistor (R FB) across the trans-impedance amplifier; a second difference amplifier configured to provide a measurement of the voltage across the resistor (R FB) to an output of the second difference amplifier, wherein the second difference amplifier is further configured to feed into the analogue-to-digital converter input of the micro-controller. a housing; a strip port connector disposed at least partially within the housing and configured to receive an electro-chemical based analytical test strip; a micro-controller disposed in the housing and configured to generate a micro-controller command signal, the micro-controller comprising an analogue-to-digital converter input; an electrode bias drive circuit block disposed in the housing and configured to generate a bias drive signal based on the micro-controller command signal; an automatic bias drive adjustment circuit block disposed in the housing and configured to receive at least one sensed electrode voltage and to adjust a bias drive signal from the electrode bias drive circuit block based on the at least one sensed electrode voltage to create an adjusted bias drive signal, wherein the automatic bias drive adjustment circuit block comprises: a first difference amplifier configured to provide the at least one sensed electrode voltage; an error amplifier configured to compare the at least one sensed electrode voltage to the generated bias drive signal; a trans-impedance amplifier configured to use the output of the error amplifier to both drive the adjusted bias drive signal and to measure at least one sensed electrode current; a resistor (R FB) across the trans-impedance amplifier; a second difference amplifier configured to provide a measurement of the voltage across the resistor (R FB) to an output of the second difference amplifier, wherein the second difference amplifier is further configured to feed into the analogue-to-digital converter input of the micro-controller. a first difference amplifier configured to provide the at least one sensed electrode voltage; an error amplifier configured to compare the at least one sensed electrode voltage to the generated bias drive signal; a trans-impedance amplifier configured to use the output of the error amplifier to both drive the adjusted bias drive signal and to measure at least one sensed electrode current; a resistor (R FB) across the trans-impedance amplifier; a second difference amplifier configured to provide a measurement of the voltage across the resistor (R FB) to an output of the second difference amplifier, wherein the second difference amplifier is further configured to feed into the analogue-to-digital converter input of the micro-controller.