mhurhangee/ep-ind-claims huggingface dataset:
A method of preparing buprenorphine, or a salt thereof, from Compound HO-I-H, or a salt thereof: comprising: (i) in a first solvent system S1 comprising a polar protic solvent, reacting Compound HO-I-H with benzyl halide, benzyl sulfonate, or activated benzyl alcohol to provide Compound BnO-I-Bn: (ii) in a second solvent system S2 comprising a polar protic solvent, reacting Compound BnO-I-Bn with methyl vinyl ketone to provide Compound BnO-II-Bn: (iii) in a third solvent system S3 comprising a nonpolar solvent, reacting Compound BnO-II-Bn with a tert-butylmagnesium compound to provide Compound BnO-IIIA-Bn: (iv) reacting Compound BnO-IIIA-Bn with H 2 in the presence of a hydrogenation catalyst to provide a compound of Compound HO-IV-H: (v) reacting Compound HO-IV-H with cyclopropane carboxaldehyde followed by a hydride source; or (v) reacting Compound HO-IV-H with cyclopropanecarboxylic acid halide followed by a reducing agent; or (v) reacting Compound HO-IV-H with cyclopropylmethyl halide or activated cyclopropane methanol; to provide buprenorphine. (i) in a first solvent system S1 comprising a polar protic solvent, reacting Compound HO-I-H with benzyl halide, benzyl sulfonate, or activated benzyl alcohol to provide Compound BnO-I-Bn: (ii) in a second solvent system S2 comprising a polar protic solvent, reacting Compound BnO-I-Bn with methyl vinyl ketone to provide Compound BnO-II-Bn: (iii) in a third solvent system S3 comprising a nonpolar solvent, reacting Compound BnO-II-Bn with a tert-butylmagnesium compound to provide Compound BnO-IIIA-Bn: (iv) reacting Compound BnO-IIIA-Bn with H 2 in the presence of a hydrogenation catalyst to provide a compound of Compound HO-IV-H: (v) reacting Compound HO-IV-H with cyclopropane carboxaldehyde followed by a hydride source; or (v) reacting Compound HO-IV-H with cyclopropanecarboxylic acid halide followed by a reducing agent; or (v) reacting Compound HO-IV-H with cyclopropylmethyl halide or activated cyclopropane methanol;
Fluid circulation valve, having a body delimiting an internal duct and comprising a flap mounted pivotably on a spindle separating said flap into a first part and a second part, said flap being able to pivot between an open position allowing the fluid to pass into the duct, and a closed position which prevents said passage and for which the first part and the second part of said flap come to rest against a seal which extends facing this first and second part, said seal further sealing the body of the valve, characterized in that said seal has pressure-lowering means (11, 12) downstream of the second part of the flap so as to increase the force for clamping said second part against said seal, in that the seal comprises two openings, a first opening facing the first part of the flap and allowing the fluid to pass into the duct when the flap is in an open position, and a second opening facing the second part of the flap and allowing a pressure drop downstream of the second part of the flap when the flap is in a closed position, and in that the pressure-lowering means comprise the second opening created in the seal, only facing the second part of the flap when the flap is in a closed position.
A door seal, comprising a fastening element for fastening to a door, a seal receiving element, a lowering mechanism unit which mechanically couples the fastening element to the seal receiving element and which is designed in order to lower the seal receiving element relative to the fastening element from a raised position into a lowered position and conversely to raise same from the lowered position to the raised position, and a sealing element which is fastened to the seal receiving element and extends in a longitudinal direction, wherein the sealing element provides a first sealing line by means of a first sealing element portion, which is lowerable and raisable by means of the lowering mechanism unit, wherein the first sealing element portion is a sealing lip and/or a sealing arc, wherein the sealing arc extends from a first arc end to a second arc end, and wherein the two arc ends are lowerable and raisable together with the seal receiving element, characterized in that the sealing element comprises a second sealing element portion, which is divided from the first sealing element portion by a groove, wherein the sealing element provides a second sealing line, which runs parallel to the first sealing line, by means of the second sealing element portion, in that the second sealing element portion has a first side and a second side (52, 56), wherein the first side is lowerable and raisable by means of the lowering mechanism unit, and the second side is fixed in the position in relation to the fastening element, and in that, in the lowered state, the first and the second sealing line (54a, 55a) seal against a surface located outside the door seal.
A method for forming a multilayer coating film by sequentially performing the following steps to: applying a colored paint to a substrate, followed by heating, to form a colored coating film, wherein the substrate is a base material on which a cationic or an anionic electrodeposition paint is applied, applying a base paint to the colored coating film formed in step to form a base coating film, applying an effect pigment dispersion to the base coating film formed in step to form an effect coating film, applying a clear paint to the effect coating film formed in step to form a clear coating film, and heating the uncured base coating film, the uncured effect coating film, and the uncured clear coating film formed in steps to to thereby simultaneously cure these three coating films; wherein the effect pigment dispersion contains water, a surface adjusting agent, a flake-effect pigment, and a rheology control agent, and has a solids content of 0.5 to 10 mass%; wherein the surface adjusting agent has a contact angle with respect to a previously degreased tin plate, as determined in accordance with the method described in the description, of 8 to 20°; wherein the rheology control agent is at least one selected from the group consisting of a mineral-based rheology control agent, a polyacrylic acid-based rheology control agent, and a cellulose-based rheology control agent. applying a colored paint to a substrate, followed by heating, to form a colored coating film, wherein the substrate is a base material on which a cationic or an anionic electrodeposition paint is applied, applying a base paint to the colored coating film formed in step to form a base coating film, applying an effect pigment dispersion to the base coating film formed in step to form an effect coating film, applying a clear paint to the effect coating film formed in step to form a clear coating film, and heating the uncured base coating film, the uncured effect coating film, and the uncured clear coating film formed in steps to to thereby simultaneously cure these three coating films; wherein the effect pigment dispersion contains water, a surface adjusting agent, a flake-effect pigment, and a rheology control agent, and has a solids content of 0.5 to 10 mass%; wherein the surface adjusting agent has a contact angle with respect to a previously degreased tin plate, as determined in accordance with the method described in the description, of 8 to 20°; wherein the rheology control agent is at least one selected from the group consisting of a mineral-based rheology control agent, a polyacrylic acid-based rheology control agent, and a cellulose-based rheology control agent.
Sanding pad (1, 20) for an in particular rotating surface finish, comprising a drive connector provided for connection to a rotating drive machine, which connector is on the top face of a support plate made from plastics material, which plate sits on an elastically deformable cushion, the bottom face of which is covered with a working medium or provided with an adhesive cover for detachably attaching a working medium disc, the support plate being provided with a cover that is axially spaced therefrom and made from plastics material, and connection pieces being arranged so as to extend predominantly radially between the support plate and the cover, the cover being designed as a mechanically loadable structural element and formed in the shape of a ring having an inner circumference and an outer circumference, and the connection pieces being rigidly connected to the support plate at least at certain points, characterised in that the connection pieces are also rigidly connected to the cover at least at certain points, the cover being welded or adhesively bonded to the support plate at the inner circumference and at the outer circumference, the cover being flush-mounted at the outer circumference thereof into the support pad and an outer edge of said cover abutting radially against an inner edge of the support pad in a tight fit, and said cover abutting radially at the inner circumference against an outwardly facing edge of the support pad.
A trip assembly for an electrical switching apparatus comprising a housing, a signaling mechanism, separable contacts, and an operating mechanism structured to open and close said separable contacts, said trip assembly comprising: a mounting assembly structured to be disposed on said housing; and a drive assembly coupled to said mounting assembly, said drive assembly comprising: an actuator structured to be cooperable with said signaling mechanism, a plunger structured to be cooperable with said operating mechanism, and a lever member structured to engage each of said actuator and said plunger 160); wherein said drive assembly is structured to move between a loaded position corresponding to said actuator being reset and an unloaded position corresponding to said actuator being extended; characterised in that as said drive assembly moves from said loaded position to said unloaded position, said actuator drives said lever member into said plunger to cause said plunger to rotate; wherein said mounting assembly comprises a first frame member, a barrier post disposed on said first frame member, and a spring extending from said barrier post; wherein said actuator comprises an elongated member; wherein said lever member comprises a recessed portion; and wherein in each of said loaded position and said unloaded position, said spring engages said recessed portion. a mounting assembly structured to be disposed on said housing; and a drive assembly coupled to said mounting assembly, said drive assembly comprising: an actuator structured to be cooperable with said signaling mechanism, a plunger structured to be cooperable with said operating mechanism, and a lever member structured to engage each of said actuator and said plunger 160); an actuator structured to be cooperable with said signaling mechanism, a plunger structured to be cooperable with said operating mechanism, and a lever member structured to engage each of said actuator and said plunger 160); wherein said drive assembly is structured to move between a loaded position corresponding to said actuator being reset and an unloaded position corresponding to said actuator being extended; characterised in that as said drive assembly moves from said loaded position to said unloaded position, said actuator drives said lever member into said plunger to cause said plunger to rotate; wherein said mounting assembly comprises a first frame member, a barrier post disposed on said first frame member, and a spring extending from said barrier post; wherein said actuator comprises an elongated member; wherein said lever member comprises a recessed portion; and wherein in each of said loaded position and said unloaded position, said spring engages said recessed portion.
A method of increasing or promoting microbial activity in soil comprising selecting soil in need of treatment and applying an effective amount of a composition comprising one or more surfactants and one or more high terpene based oils, selected from the group consisting of citrus peel oils, preferably orange oil, grapefruit oil, lemon oil, lime oil, tangerine oil or pine oil and naturally occurring oils of plants that contain 50% terpene or more terpenes, and propylene glycol to the soil in need of treatment to thereby increase or promote microbial activity in the soil selected for treatment compared to untreated soil.
Mounting device for mounting a clamp-on flowmeter on a measuring tube through which fluid can flow, wherein the mounting device has two holding straps (4, 17) provided with catches on a free end and on a second end, on which a catch means (5, 15) is attached, wherein the holding strap (4, 17) and the catch means (5, 15) are each such designed that the holding strap (4, 17) can be attached to the measuring tube, in that the holding strap (4, 17) is guided into and through the catch means (5, 15) and pulled tight after the holding strap (4, 7) has been routed around the measuring tube, in that a catch element provided in the catch means (5, 15) interacts with the catch of the holding strap (4, 7) and ensures that the holding strap (4, 7) cannot become unfastened, in that a threaded rod attached to the catch means (5, 15) is provided, onto which the clamp-on flowmeter can be attached, the clamp-on flowmeter being attachable to the measuring tube by means of a screw means that is screwable onto the threaded rod and the holding strap (4, 7) can be completely tensioned in that the the screw means is screwed onto the threaded rod and thereby acts on the clamp-on flowmeter, the measuring tube being provided as an abutment for it, so that the catch means (5, 15) is lifted off the measuring tube, whereby the clamp-on flowmeter is held and fixed to the measuring tube, wherein by raising a lever (8, 10) of the catch means (5, 15), the respective holding strap (4, 17) can be pulled out of the catch means (5, 15) again.
An apparatus for measuring at least the speed of sound through a fluid or a mixture of fluids in a pipe, comprising: a spatial array of at least two pressure sensors (14, 16, 18), disposed at different axial locations along the pipe, and each arranged to measure an acoustic pressure comprising background acoustic noise within the pipe at a corresponding axial location, each of said sensors arranged to provide an acoustic pressure signal representative of the background acoustic noise within the pipe at said axial location of a corresponding one of said sensors; and a signal processor, responsive to said pressure signals, arranged to provide a signal representative of the speed of sound through the fluid or the mixture of fluids in the pipe. a spatial array of at least two pressure sensors (14, 16, 18), disposed at different axial locations along the pipe, and each arranged to measure an acoustic pressure comprising background acoustic noise within the pipe at a corresponding axial location, each of said sensors arranged to provide an acoustic pressure signal representative of the background acoustic noise within the pipe at said axial location of a corresponding one of said sensors; and a signal processor, responsive to said pressure signals, arranged to provide a signal representative of the speed of sound through the fluid or the mixture of fluids in the pipe.
A pharmaceutical composition for use in a method of treating lung cancer or pancreatic cancer, the composition comprising nanoparticles encapsulating RNAi molecules, wherein the RNAi molecules are targeted to Hsp47.
A user equipment (140, 400) comprising: means adapted for broadcasting a pilot signal to a plurality of network nodes in a network to advertise the user equipment (140, 400) to the plurality of network nodes; means adapted for receiving a pilot response from a first network node in response to the first network node receiving the broadcast pilot signal, the pilot response reporting to the user equipment selection of the first network node as a serving node for the user equipment (140, 400); and means adapted for communicating with the network through the serving node; wherein the pilot signal includes a reference sequence followed by a payload including information about an identity of the user equipment (140, 400), the reference sequence comprising a signaling pattern to support recognition of the pilot signal as a pilot signal by the plurality of network nodes and tracking of the pilot signal by the plurality of network nodes. means adapted for broadcasting a pilot signal to a plurality of network nodes in a network to advertise the user equipment (140, 400) to the plurality of network nodes; means adapted for receiving a pilot response from a first network node in response to the first network node receiving the broadcast pilot signal, the pilot response reporting to the user equipment selection of the first network node as a serving node for the user equipment (140, 400); and means adapted for communicating with the network through the serving node; wherein the pilot signal includes a reference sequence followed by a payload including information about an identity of the user equipment (140, 400), the reference sequence comprising a signaling pattern to support recognition of the pilot signal as a pilot signal by the plurality of network nodes and tracking of the pilot signal by the plurality of network nodes.
A roller drafting device for spinnery machines, the coating for the pressure roller at the discharge of a drafting zone consisting of an outer layer and an inner layer that is attached to the pressure roller core, the outer layer being thinner and harder than the inner layer and implemented as an endless apron loosely enclosing the inner layer so that the apron can be displaced relative to the inner layer and slides over a deflecting rail (2, 20, 21, 22, 25, 200), characterized in that the deflecting rail (2, 20, 21, 22, 25, 200) comprises a cross-sectional circumference that is greater than the average staple length of the fiber material to be drafted on the roller drafting device.
Sports field, comprising a base structure and a cover, wherein the cover is at least partly permeable to fluid, especially water, wherein the cover comprises a top layer and a shock absorbing layer provided between the top layer and the base structure, wherein the shock absorbing layer has upper and lower surfaces (38T, 38L) and comprises man made vitreous fibres (MMVF) bonded by a cured binder and/or cell foam, wherein the shock absorbing layer has a thickness (D 38) between the upper surface and lower surface of between 12 and 40 mm and has a density of between 175 kg/m 3 and 300 kg/m 3, wherein the shock absorbing layer is hydrophilic, such that it can absorb a volume of water of between at least 20 to 95% of the volume of the shock absorbing layer.
A mobile device (200,1100), comprising: a location information acquiring unit (210, 1196) configured to acquire a location of the mobile device (200, 1100); an image pickup unit configured to capture an image comprising a building; a first sensor configured to detect a direction of the building and a second sensor configured to detect a distance to the building; a display; a communication unit (220, 1195) configured to communicate with a server; and a control unit (260, 1140) configured to: control the communication unit to transmit the location, the direction and the distance to the server for calculation of a location on a map; receive, from the server, building information corresponding to the location on a map; control the display to display the received building information on the captured image comprising the building; and the control unit (260, 1140) is further configured to, in response to a category being selected by a user among a plurality of categories, control the display to display building information corresponding to the selected category among the received building information distinctively from building information corresponding to remaining categories. a location information acquiring unit (210, 1196) configured to acquire a location of the mobile device (200, 1100); an image pickup unit configured to capture an image comprising a building; a first sensor configured to detect a direction of the building and a second sensor configured to detect a distance to the building; a display; a communication unit (220, 1195) configured to communicate with a server; and a control unit (260, 1140) configured to: control the communication unit to transmit the location, the direction and the distance to the server for calculation of a location on a map; receive, from the server, building information corresponding to the location on a map; control the display to display the received building information on the captured image comprising the building; and the control unit (260, 1140) is further configured to, in response to a category being selected by a user among a plurality of categories, control the display to display building information corresponding to the selected category among the received building information distinctively from building information corresponding to remaining categories. control the communication unit to transmit the location, the direction and the distance to the server for calculation of a location on a map; receive, from the server, building information corresponding to the location on a map; control the display to display the received building information on the captured image comprising the building; and the control unit (260, 1140) is further configured to, in response to a category being selected by a user among a plurality of categories, control the display to display building information corresponding to the selected category among the received building information distinctively from building information corresponding to remaining categories.
A device for inserting a balancing weight into a rotor of a turbine, comprising - an external component, - an internal component which is connected in a helical manner to the external component, characterized in that the internal component delimits a chamber which has a first and a second opening and comprises a lower surface which is provided with a sealing joint, and a cap in order to close in a tight manner the first opening of the chamber. - an external component, - an internal component which is connected in a helical manner to the external component, characterized in that the internal component delimits a chamber which has a first and a second opening and comprises a lower surface which is provided with a sealing joint, and a cap in order to close in a tight manner the first opening of the chamber.
Cooktop device having at least one heater arrangement, which has at least two heating elements, which are arranged adjacent to one another and are provided at least to heat positioned cookware, and having at least one control unit, characterised in that the control unit is provided to define, at least in one operating mode, a number of virtual heating zones with different heat output densities depending on a size of at least one positioned piece of cookware, wherein the virtual heating zones are formed by adjacently arranged heating elements, which are suitable by the number and/or size thereof for operating the cookware.