A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl; R 2, R 3, R 4, and R 5 are each independently hydrogen, halo, cyano, optionally substituted alkoxy, or optionally substituted alkyl; R 6, R 7, R 8 and R 10 are each independently hydrogen, cyano, or halo; R 9 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; R 11 is -COR 12, -CO 2 R 12 or -CONR 12 R 13; R 12 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R 13 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 12, R 13, and the nitrogen to which they are attached form an optionally substituted heterocycloalkyl ring; wherein each optionally substituted group is unsubstituted or independently substituted with one or more substituents independently selected from the group consisting of C 1 -C 4 alkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl, -OC 1 -C 4 alkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -CO 2 H, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 alkylphenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); provided that when R 10 is fluoro, then R 7 is not hydrogen, or R 8 is not hydrogen, or R 6 is not hydrogen, C 1 -C 6 alkyl or halo. R 1 is hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl; R 2, R 3, R 4, and R 5 are each independently hydrogen, halo, cyano, optionally substituted alkoxy, or optionally substituted alkyl; R 6, R 7, R 8 and R 10 are each independently hydrogen, cyano, or halo; R 9 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; R 11 is -COR 12, -CO 2 R 12 or -CONR 12 R 13; R 12 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R 13 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R 12, R 13, and the nitrogen to which they are attached form an optionally substituted heterocycloalkyl ring; wherein each optionally substituted group is unsubstituted or independently substituted with one or more substituents independently selected from the group consisting of C 1 -C 4 alkyl, aryl, heteroaryl, aryl-C 1 -C 4 alkyl-, heteroaryl-C 1 -C 4 alkyl-, C 1 -C 4 haloalkyl, -OC 1 -C 4 alkyl, -OC 1 -C 4 alkylphenyl, -C 1 -C 4 alkyl-OH, -OC 1 -C 4 haloalkyl, halo, -OH, -NH 2, -C 1 -C 4 alkyl-NH 2, -N(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -NH(C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)(C 1 -C 4 alkylphenyl), -NH(C 1 -C 4 alkylphenyl), cyano, nitro, oxo, -CO 2 H, -C OC 1 -C 4 alkyl, -CON(C 1 -C 4 alkyl)(C 1 -C 4 alkyl), -CONH(C 1 -C 4 alkyl), -CONH 2, -NHC (C 1 -C 4 alkyl), -NHC (phenyl), -N(C 1 -C 4 alkyl)C (C 1 -C 4 alkyl), -N(C 1 -C 4 alkyl)C (phenyl), -C C 1 -C 4 alkyl, -C C 1 -C 4 alkylphenyl, -C C 1 -C 4 haloalkyl, -OC C 1 -C 4 alkyl, -SO 2 (C 1 -C 4 alkyl), -SO 2 (phenyl), -SO 2 (C 1 -C 4 haloalkyl), -SO 2 NH 2, -SO 2 NH(C 1 -C 4 alkyl), -SO 2 NH(phenyl), -NHSO 2 (C 1 -C 4 alkyl), -NHSO 2 (phenyl), and -NHSO 2 (C 1 -C 4 haloalkyl); provided that when R 10 is fluoro, then R 7 is not hydrogen, or R 8 is not hydrogen, or R 6 is not hydrogen, C 1 -C 6 alkyl or halo.