mhurhangee/ep-ind-claims huggingface dataset:
A method for screening a candidate compound for its ability to interact with at least one transmembrane protein comprising: contacting a cell with a candidate compound, wherein the cell is transfected with at least one nucleotide sequence encoding a protein comprising a transmembrane protein containing at least one nuclear localisation sequence and a detectable moiety and the encoded protein is expressed in the cell, and wherein the transmembrane protein exhibits ligand-independent transfer away from the cell membrane and into the cell nucleus; and determining the distribution of the expressed protein in the cell by detecting the distribution of the detectable moiety in the cell; wherein retention of the detectable moiety at the cell membrane in cells contacted with the candidate compound, relative to control cells not contacted with the candidate compound, indicates interaction of the candidate compound with the transmembrane protein, and wherein the wild type transmembrane protein contains an NLS. contacting a cell with a candidate compound, wherein the cell is transfected with at least one nucleotide sequence encoding a protein comprising a transmembrane protein containing at least one nuclear localisation sequence and a detectable moiety and the encoded protein is expressed in the cell, and wherein the transmembrane protein exhibits ligand-independent transfer away from the cell membrane and into the cell nucleus; and determining the distribution of the expressed protein in the cell by detecting the distribution of the detectable moiety in the cell; wherein retention of the detectable moiety at the cell membrane in cells contacted with the candidate compound, relative to control cells not contacted with the candidate compound, indicates interaction of the candidate compound with the transmembrane protein, and
Wiper device for an optical device of a motor vehicle, having at least one wiper element which is movable when transferred from a first end position into a second end position via a surface of a disc- and/or dome-shaped optical element of the optical device and having at least one drive unit, which comprises at least one holding means for fixing the wiper element to the drive unit as well as at least one first drive means and at least one second drive means of which at least one drive means (12, 14) has at least one shape memory element at least in sections, characterised in that the first drive means and/or the second drive means comprises at least one kinematics by way of which the wiper element can be transferred from the first end position into the second end position by a translational movement, in particular a linear movement.
Method for connecting an end device to a linkable computer infrastructure, wherein a device certificate is created and supplied to a user of the end device, wherein the device certificate is input into the end device, which device certificate is created as a uniform device certificate once for a large number of end devices, wherein a data link from the end device to an access zone connected upstream of the functions of the linkable computer infrastructure is produced, which zone can be selectively separated from the functions of the linkable computer infrastructure by this link, wherein the end device is registered in the access zone using the device certificate, wherein by access of a function from the linkable computer infrastructure to the end device registered in the access zone, this end device is identified for the linkable computer infrastructure, and wherein with successful identification of the end device, use of the linkable computer infrastructure is enabled for this end device, by a use token being allocated to the end device by means of an access zone management, which use token can be identified by a corresponding user space of the linkable computer infrastructure. wherein a device certificate is created and supplied to a user of the end device, wherein the device certificate is input into the end device, which device certificate is created as a uniform device certificate once for a large number of end devices, wherein a data link from the end device to an access zone connected upstream of the functions of the linkable computer infrastructure is produced, which zone can be selectively separated from the functions of the linkable computer infrastructure by this link, wherein the end device is registered in the access zone using the device certificate, wherein by access of a function from the linkable computer infrastructure to the end device registered in the access zone, this end device is identified for the linkable computer infrastructure, and wherein with successful identification of the end device, use of the linkable computer infrastructure is enabled for this end device, by a use token being allocated to the end device by means of an access zone management, which use token can be identified by a corresponding user space of the linkable computer infrastructure.
An adjustment mechanism comprising a cover forming a protective surface for a pressure plate and the other parts, at least one diaphragm spring, at least one return spring, an adjustment member positioned on the pressure plate, a setup ramp and a stopping ramp; characterized in that: - the set-up ramp is connected to a bedding slot (101.1) of the mentioned pressure plate and on which the stopping ramp is positioned, - the stopping ramp is connected both to a stopper and to a set-up element, - the stopper is connected to the stopping ramp and to the pressure plate mentioned, - the set-up element ensures that the stopping ramp remains stationary when wear occurs, - a support spring for performing the pulling action until mentioned set-up ramp bears on the stopping ramp when wear occur, - a cover hole (103.1) drilled on the cover to ensure that the mentioned set-up element can be operated, - a gap (104.1) drilled on the diaphragm spring to enable the proper operation of the mentioned set-up element and the stopping ramp, - a stopping channel (106.1) on the adjustment member, which allows the stopper to remain in a constant contact with the adjustment member. - the set-up ramp is connected to a bedding slot (101.1) of the mentioned pressure plate and on which the stopping ramp is positioned, - the stopping ramp is connected both to a stopper and to a set-up element, - the stopper is connected to the stopping ramp and to the pressure plate mentioned, - the set-up element ensures that the stopping ramp remains stationary when wear occurs, - a support spring for performing the pulling action until mentioned set-up ramp bears on the stopping ramp when wear occur, - a cover hole (103.1) drilled on the cover to ensure that the mentioned set-up element can be operated, - a gap (104.1) drilled on the diaphragm spring to enable the proper operation of the mentioned set-up element and the stopping ramp, - a stopping channel (106.1) on the adjustment member, which allows the stopper to remain in a constant contact with the adjustment member.
A process for the manufacture of a compound of formula II by reduction of a compound of formula I with hydrogen in the presence of a catalyst comprising nickel, wherein an additive is present, and wherein n is either 1 or 2, preferably wherein n is 1; wherein R 1 is linear C 1-4 alkyl or branched C 3-4 alkyl, preferably wherein R 1 is methyl or ethyl, and wherein R 2 is hydrogen or linear C 1-4 alkyl or branched C 3-4 alkyl, preferably wherein R 2 is hydrogen or methyl, and more preferably wherein either R 1 is methyl or R 2 is hydrogen wherein the additive is selected from the group of additives containing a nitrogen or a sulfur atom, wherein the additive containing a sulfur atom is selected from the group of aromatic disulfides, aliphatic disulfides, aromatic sulfides, heteroaromatic sulfides, aliphatic sulfides, aromatic thiols, heteroaromatic thiols, aliphatic thiols, each containing a total number of 2-15 carbon atoms and a total number of 1 or 2 sulfur atoms, respectively, and wherein the additive containing a nitrogen atom is selected from the group of aliphatic primary amines containing a total number of 3-10 carbon atoms and 1-3 nitrogen atoms and C6-C10 bicyclic aliphatic amidines; and wherein the reduction with hydrogen is carried out at an absolute hydrogen pressure in the range of 1 to 20 bar.
A gas turbine engine defining a radial direction and an axial direction, the gas turbine engine comprising: a compressor section and a turbine section arranged in serial flow order, the compressor section and turbine section together defining a core air flowpath; a rotary component rotatable with at least a portion of the compressor section and with at least a portion of the turbine section; a static frame member; a rotor connection member; a stator connection member; and an electric machine comprising a rotor and a stator, the rotor being disposed outside the stator in the radial direction and rotatable with the rotary component, the electric machine positioned at least partially inward of the core air flowpath along the radial direction, the electric machine flexibly mounted to the static frame member, or flexibly coupled to the rotary component, or both; wherein the rotor connection member supports the rotor of the electric machine, and the rotor connection member flexibly couples the rotor to the rotary component of the gas turbine engine; the stator connection member supports the stator of the electric machine, and the stator connection member flexibly mounts the stator to the static frame member at a location forward of the stator along the axial direction of the gas turbine engine; and the electric machine is positioned at least partially within or aft of the turbine section along the axial direction. a compressor section and a turbine section arranged in serial flow order, the compressor section and turbine section together defining a core air flowpath; a rotary component rotatable with at least a portion of the compressor section and with at least a portion of the turbine section; a static frame member; a rotor connection member; a stator connection member; and an electric machine comprising a rotor and a stator, the rotor being disposed outside the stator in the radial direction and rotatable with the rotary component, the electric machine positioned at least partially inward of the core air flowpath along the radial direction, the electric machine flexibly mounted to the static frame member, or flexibly coupled to the rotary component, or both; wherein the rotor connection member supports the rotor of the electric machine, and the rotor connection member flexibly couples the rotor to the rotary component of the gas turbine engine; the stator connection member supports the stator of the electric machine, and the stator connection member flexibly mounts the stator to the static frame member at a location forward of the stator along the axial direction of the gas turbine engine; and the electric machine is positioned at least partially within or aft of the turbine section along the axial direction.
An acoustic logging tool for determining a parameter quantifying anisotropy of a formation penetrated by a borehole, said tool comprising: a unipole acoustic source; and a receiver section comprising a plurality of receiver stations at differing axial spacings from said acoustic source; wherein said source and said receiver section are configured to be synchronously rotatable within said borehole; and a processor configured to: measure responses of said receiver stations in azimuthal angular segments; process said responses to determine shear velocity of said formation as a function of azimuthal angle; and characterized in that the processor is further configure to: determine said parameter quantifying anisotropy of said formation using said shear velocities as a function of said azimuthal angle by detecting an abrupt change in shear velocity, wherein said parameter includes an angular direction of minimum/maximum stress of said formation. a unipole acoustic source; and a receiver section comprising a plurality of receiver stations at differing axial spacings from said acoustic source; wherein said source and said receiver section are configured to be synchronously rotatable within said borehole; and a processor configured to: measure responses of said receiver stations in azimuthal angular segments; process said responses to determine shear velocity of said formation as a function of azimuthal angle; and characterized in that the processor is further configure to: determine said parameter quantifying anisotropy of said formation using said shear velocities as a function of said azimuthal angle by detecting an abrupt change in shear velocity, wherein said parameter includes an angular direction of minimum/maximum stress of said formation. measure responses of said receiver stations in azimuthal angular segments; process said responses to determine shear velocity of said formation as a function of azimuthal angle; and characterized in that the processor is further configure to: determine said parameter quantifying anisotropy of said formation using said shear velocities as a function of said azimuthal angle by detecting an abrupt change in shear velocity, wherein said parameter includes an angular direction of minimum/maximum stress of said formation. determine said parameter quantifying anisotropy of said formation using said shear velocities as a function of said azimuthal angle by detecting an abrupt change in shear velocity, wherein said parameter includes an angular direction of minimum/maximum stress of said formation.
A method for wireless communication, comprising: receiving, at a relay device, a pre-wakeup, PWU, signal from a user equipment, UE, during a PWU period that is prior to a discovery period, wherein the discovery period is based at least in part on a periodic wakeup configuration; and transmitting, from the relay device, a discovery broadcast during the discovery period based at least in part on receiving the PWU signal. receiving, at a relay device, a pre-wakeup, PWU, signal from a user equipment, UE, during a PWU period that is prior to a discovery period, wherein the discovery period is based at least in part on a periodic wakeup configuration; and transmitting, from the relay device, a discovery broadcast during the discovery period based at least in part on receiving the PWU signal.
A grinding machine for sharpening an edge tool, the grinding machine comprising: a circular grindstone having a rotation axis; and a motor adapted to drive the circular grindstone such that the circular grindstone is capable of rotating around its rotation axis; a support bar arranged in parallel to said rotation axis, wherein the support bar is for supporting the edge tool and wherein the support bar further comprises first and second cylindrical ends extending parallel to each other outwardly from the support bar; and a grinding machine casing comprising a first bracket and a second bracket (40"), the first bracket comprising a first hole adapted to receive the first cylindrical end of the support bar, and the second bracket (40") comprising a second hole (50") adapted to receive the second cylindrical end of the support bar simultaneously, wherein the first and second cylindrical ends are removable from the first and second holes (50'; 50"), respectively, and wherein one of the first hole or the second hole comprises a circular cross-section, characterized in that the other of the first hole or the second hole (50") comprises a non-circular cross-section. a circular grindstone having a rotation axis; and a motor adapted to drive the circular grindstone such that the circular grindstone is capable of rotating around its rotation axis; a support bar arranged in parallel to said rotation axis, wherein the support bar is for supporting the edge tool and wherein the support bar further comprises first and second cylindrical ends extending parallel to each other outwardly from the support bar; and a grinding machine casing comprising a first bracket and a second bracket (40"), the first bracket comprising a first hole adapted to receive the first cylindrical end of the support bar, and the second bracket (40") comprising a second hole (50") adapted to receive the second cylindrical end of the support bar simultaneously, wherein the first and second cylindrical ends are removable from the first and second holes (50'; 50"), respectively, and wherein one of the first hole or the second hole comprises a circular cross-section, characterized in that the other of the first hole or the second hole (50") comprises a non-circular cross-section.
A synergistic combination of (i) a pharmaceutical composition comprising glatiramer acetate, the pharmaceutical composition being in a sustained release depot form, and (ii) human adipose-derived stem cells (hADSCs), for use in the treatment of inflammatory bowel disease.
A compound of formula: wherein R a represents a C 1-3 alkyl group, such as methyl or ethyl, in particular methyl, and P 1 represents an amine protecting group selected from: tert -butyloxycarbonyl; 9-fluorenylmethyloxycarbonyl (FMOC); acetyl (Ac); benzoyl (Bz); carbamate; p-methoxyphenyl; tosyl (Ts); a sulfonamide selected from Nosyl and Nps and trifluoroacetyl, preferably wherein P 1 represents tert -butyloxycarbonyl.
A film, which is a bimorph-type piezoelectric film comprising - a first pyroelectric film having piezoelectric anisotropy in an in-plane direction, and - a second pyroelectric film having piezoelectric anisotropy in an in-plane direction, the first pyroelectric film and the second pyroelectric film being disposed in such a manner that their surfaces on which electric charges of the same polarity are generated by a temperature increase are each outward-facing; characterised in that the 31 directions of the first and the second pyroelectric film have a deviation in a rotational direction, the 31 direction being defined as a direction in which drawing the pyroelectric film generates the maximum charge per unit area when the film is drawn in various directions with a constant force not higher than the yield stress, or in such a manner that the strain generated by a force not higher than the yield stress is constant. - a first pyroelectric film having piezoelectric anisotropy in an in-plane direction, and - a second pyroelectric film having piezoelectric anisotropy in an in-plane direction, the first pyroelectric film and the second pyroelectric film being disposed in such a manner that their surfaces on which electric charges of the same polarity are generated by a temperature increase are each outward-facing; the 31 directions of the first and the second pyroelectric film have a deviation in a rotational direction, the 31 direction being defined as a direction in which drawing the pyroelectric film generates the maximum charge per unit area when the film is drawn in various directions with a constant force not higher than the yield stress, or in such a manner that the strain generated by a force not higher than the yield stress is constant.
Camshaft arrangement comprising a camshaft, a vane-type camshaft phaser attached to a first end of the camshaft, a valve actuating arrangement and an oil control valve, wherein the oil control valve comprises an elongated valve member arranged centrally inside the camshaft, where the elongated valve member can be adjusted in a longitudinal direction of the camshaft so as to control the oil flow to the vane-type camshaft phaser, wherein the valve actuating arrangement comprises a first valve actuating configuration attached to the camshaft and a second valve actuating configuration comprising an actuation arm connected to an actuator, the first valve actuating configuration being arranged to be actuated by the actuation arm of the second valve actuating configuration, thereby adjusting the elongated valve member.
A method for non-destructively detecting deviating additive manufacturing process behaviour of a 3D printed solid piece, comprising the steps of: - providing a mechanical impact to the solid piece; - obtaining a vibrational response of the solid piece to the impact in the frequency domain; - extracting a set of eigenfrequencies, and a set of attenuations, from the vibrational response, each of said eigenfrequencies corresponding to a vibrational mode of said solid piece, and each of said attenuations corresponding to an eigenfrequency of said set of eigenfrequencies; - obtaining for at least one vibrational mode: • an eigenfrequency shift by comparing one of the set of extracted eigenfrequencies corresponding to said vibrational mode to a reference eigenfrequency value of said vibrational mode and obtaining a porosity value of the solid piece from said eigenfrequency shift, and • for said at least one eigenfrequency, computing at least one damping parameter an attenuation corresponding to said eigenfrequency, thereby obtaining a microcrack quantity value of the solid piece, thereby detecting the deviating AM process behaviour. - providing a mechanical impact to the solid piece; - obtaining a vibrational response of the solid piece to the impact in the frequency domain; - extracting a set of eigenfrequencies, and a set of attenuations, from the vibrational response, each of said eigenfrequencies corresponding to a vibrational mode of said solid piece, and each of said attenuations corresponding to an eigenfrequency of said set of eigenfrequencies; - obtaining for at least one vibrational mode: • an eigenfrequency shift by comparing one of the set of extracted eigenfrequencies corresponding to said vibrational mode to a reference eigenfrequency value of said vibrational mode and obtaining a porosity value of the solid piece from said eigenfrequency shift, and • for said at least one eigenfrequency, computing at least one damping parameter an attenuation corresponding to said eigenfrequency, thereby obtaining a microcrack quantity value of the solid piece, thereby detecting the deviating AM process behaviour. • an eigenfrequency shift by comparing one of the set of extracted eigenfrequencies corresponding to said vibrational mode to a reference eigenfrequency value of said vibrational mode and obtaining a porosity value of the solid piece from said eigenfrequency shift, and • for said at least one eigenfrequency, computing at least one damping parameter an attenuation corresponding to said eigenfrequency, thereby obtaining a microcrack quantity value of the solid piece,
A condenser comprising: a refrigerant pipe having at least a portion thereof disposed along a first direction, and configured so that a refrigerant flows therethrough; a plate fin coupled to one side portion of the refrigerant pipe, wherein the refrigerant pipe comprises: an inlet part and an outlet part through which the refrigerant is introduced and discharged; and a main refrigerant pipe comprising heat radiating pipes formed along the first direction and a bent pipe connecting end portions of the heat radiating pipes, the main refrigerant pipe having both end portions thereof connected to the inlet part and the outlet part, respectively, and coupled to the plate fin, characterized in that the condenser further comprises a wave fin provided to make contact with a rear surface portion of the plate fin, and formed along the first direction in a bent manner. a refrigerant pipe having at least a portion thereof disposed along a first direction, and configured so that a refrigerant flows therethrough; a plate fin coupled to one side portion of the refrigerant pipe, an inlet part and an outlet part through which the refrigerant is introduced and discharged; and a main refrigerant pipe comprising heat radiating pipes formed along the first direction and a bent pipe connecting end portions of the heat radiating pipes, the main refrigerant pipe having both end portions thereof connected to the inlet part and the outlet part, respectively, and coupled to the plate fin,