A compound of formula, wherein X is CH or N; R 1 is H or NHR 3, wherein R 3 is H, an optionally substituted group selected from straight or branched C 1 -C 3 alkyl, heterocyclyl and COR', wherein R' is an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, a C 3 -C 6 carbocyclyl, aryl and heteroaryl; L 1 is C ≡ C; Q is an optionally substituted aryl or heteroaryl selected from: wherein Rc is selected from methyl and halogen, preferably fluorine; L 2 is CONRa, C(RaRb)CONRa, C(RaRb)C(RaRb)CONRa, CONRaC(RaRb), OC(RaRb)CONRa, wherein Ra and Rb are both hydrogen; T is a substituted aryl of formula J: wherein Rd is halogen, optionally substituted straight or branched C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl or trifluoromethyl; L 3 is direct linkage, O, NH, NCH 3, CH 2, CH 2 NH, CH 2 NCH 3 or C=O; Re is NRfRg, whereinRf and Rg are each independently an optionally substituted straight or branched C 1 -C 6 alkyl chain, wherein from 1 to 3 carbon atoms of said alkyl may be substituted independently by N or O, or Rf and Rg joined together with the nitrogen atom, represent a heterocyclic ring; R 2 is H or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 carbocyclyl, heterocyclyl, aryl and heteroaryl; or pharmaceutically acceptable salts thereof. X is CH or N; R 1 is H or NHR 3, wherein R 3 is H, an optionally substituted group selected from straight or branched C 1 -C 3 alkyl, heterocyclyl and COR', wherein R' is an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, a C 3 -C 6 carbocyclyl, aryl and heteroaryl; L 1 is C ≡ C; Q is an optionally substituted aryl or heteroaryl selected from: wherein Rc is selected from methyl and halogen, preferably fluorine; L 2 is CONRa, C(RaRb)CONRa, C(RaRb)C(RaRb)CONRa, CONRaC(RaRb), OC(RaRb)CONRa, wherein Ra and Rb are both hydrogen; T is a substituted aryl of formula J: wherein Rd is halogen, optionally substituted straight or branched C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl or trifluoromethyl; L 3 is direct linkage, O, NH, NCH 3, CH 2, CH 2 NH, CH 2 NCH 3 or C=O; Re is NRfRg, whereinRf and Rg are each independently an optionally substituted straight or branched C 1 -C 6 alkyl chain, wherein from 1 to 3 carbon atoms of said alkyl may be substituted independently by N or O, or Rf and Rg joined together with the nitrogen atom, represent a heterocyclic ring; R 2 is H or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 carbocyclyl, heterocyclyl, aryl and heteroaryl; or pharmaceutically acceptable salts thereof. wherein Rc is selected from methyl and halogen, preferably fluorine; L 2 is CONRa, C(RaRb)CONRa, C(RaRb)C(RaRb)CONRa, CONRaC(RaRb), OC(RaRb)CONRa, wherein Ra and Rb are both hydrogen; T is a substituted aryl of formula J: wherein Rd is halogen, optionally substituted straight or branched C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl or trifluoromethyl; L 3 is direct linkage, O, NH, NCH 3, CH 2, CH 2 NH, CH 2 NCH 3 or C=O; Re is NRfRg, whereinRf and Rg are each independently an optionally substituted straight or branched C 1 -C 6 alkyl chain, wherein from 1 to 3 carbon atoms of said alkyl may be substituted independently by N or O, or Rf and Rg joined together with the nitrogen atom, represent a heterocyclic ring; R 2 is H or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 carbocyclyl, heterocyclyl, aryl and heteroaryl; or pharmaceutically acceptable salts thereof. Rd is halogen, optionally substituted straight or branched C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl or trifluoromethyl; L 3 is direct linkage, O, NH, NCH 3, CH 2, CH 2 NH, CH 2 NCH 3 or C=O; Re is NRfRg, whereinRf and Rg are each independently an optionally substituted straight or branched C 1 -C 6 alkyl chain, wherein from 1 to 3 carbon atoms of said alkyl may be substituted independently by N or O, or Rf and Rg joined together with the nitrogen atom, represent a heterocyclic ring; R 2 is H or an optionally substituted group selected from straight or branched C 1 -C 6 alkyl, C 3 -C 6 carbocyclyl, heterocyclyl, aryl and heteroaryl;