A method for handling microparticles, where the microparticles are used as a solid phase to bind a desired component from a sample, wherein the desired component is various biomolecules, nucleic acid, protein, peptide, cell organelles, bacteria, cells or viruses, wherein - at least two treatment steps of the microparticles are performed in the same vessel without moving the microparticles to another vessel, - the microparticles are magnetic particles that are ferromagnetic, paramagnetic or superparamagnetic, - the treatment steps are at least one change of solutions and at least one mixing, - the microparticles are treated by a magnetic tool equipped with a protective shield, - in the vessel the microparticles are collected and bound on the protective shield of the magnetic tool prior to the change of solutions, - the microparticles are mixed by means of the magnetic tool, so that the protective shield of the tool is moved in the solution, and comprising (a) - using an external magnet and a ferromagnetic sleeve or plate to remove or create a magnetic field in the vessel; - removing a solution from the vessel by either aspirating the solution through a filter or membrane on the bottom of the vessel or by means of a pipette or washing device from the top of the vessel, wherein the microparticles are collected before removing the solution on the inner surface of the vessel to form a layer; or (b) - using an external magnet and a ferromagnetic sleeve or plate; wherein the magnet and the ferromagnetic sleeve are transversely magnetized; additionally there is a spring suspension under the magnet; by pressing the vessel plate downwards, the vessel simultaneously presses the magnet inside the ferromagnetic sleeve and the spring under the magnet tightens; when the magnet is inside the ferromagnetic sleeve, there is no magnetic field outside and the microparticles stay homogenized in the solution. - at least two treatment steps of the microparticles are performed in the same vessel without moving the microparticles to another vessel, - the microparticles are magnetic particles that are ferromagnetic, paramagnetic or superparamagnetic, - the treatment steps are at least one change of solutions and at least one mixing, - the microparticles are treated by a magnetic tool equipped with a protective shield, - in the vessel the microparticles are collected and bound on the protective shield of the magnetic tool prior to the change of solutions, - the microparticles are mixed by means of the magnetic tool, so that the protective shield of the tool is moved in the solution, and comprising (a) - using an external magnet and a ferromagnetic sleeve or plate to remove or create a magnetic field in the vessel; - removing a solution from the vessel by either aspirating the solution through a filter or membrane on the bottom of the vessel or by means of a pipette or washing device from the top of the vessel, wherein the microparticles are collected before removing the solution on the inner surface of the vessel to form a layer; or (b) - using an external magnet and a ferromagnetic sleeve or plate; wherein the magnet and the ferromagnetic sleeve are transversely magnetized; additionally there is a spring suspension under the magnet; by pressing the vessel plate downwards, the vessel simultaneously presses the magnet inside the ferromagnetic sleeve and the spring under the magnet tightens; when the magnet is inside the ferromagnetic sleeve, there is no magnetic field outside and the microparticles stay homogenized in the solution. (a) - using an external magnet and a ferromagnetic sleeve or plate to remove or create a magnetic field in the vessel; - removing a solution from the vessel by either aspirating the solution through a filter or membrane on the bottom of the vessel or by means of a pipette or washing device from the top of the vessel, wherein the microparticles are collected before removing the solution on the inner surface of the vessel to form a layer; or - using an external magnet and a ferromagnetic sleeve or plate to remove or create a magnetic field in the vessel; - removing a solution from the vessel by either aspirating the solution through a filter or membrane on the bottom of the vessel or by means of a pipette or washing device from the top of the vessel, wherein the microparticles are collected before removing the solution on the inner surface of the vessel to form a layer; or (b) - using an external magnet and a ferromagnetic sleeve or plate; wherein the magnet and the ferromagnetic sleeve are transversely magnetized; additionally there is a spring suspension under the magnet; by pressing the vessel plate downwards, the vessel simultaneously presses the magnet inside the ferromagnetic sleeve and the spring under the magnet tightens; when the magnet is inside the ferromagnetic sleeve, there is no magnetic field outside and the microparticles stay homogenized in the solution. - using an external magnet and a ferromagnetic sleeve or plate; wherein the magnet and the ferromagnetic sleeve are transversely magnetized; additionally there is a spring suspension under the magnet; by pressing the vessel plate downwards, the vessel simultaneously presses the magnet inside the ferromagnetic sleeve and the spring under the magnet tightens; when the magnet is inside the ferromagnetic sleeve, there is no magnetic field outside and the microparticles stay homogenized in the solution.