A dosage form comprising a first portion, a second portion and an active ingredient, said first portion of said dosage form including a first pH-adjusting substance, said second portion of said dosage form comprising a second pH-adjusting substance, said second portion (a) being dispersed in a controlled release matrix material, and said first portion of said dosage form includes said active ingredient; or (b) comprising said second pH-adjusting substance surrounded by a coating, said first pH-adjusting substance being peripheral to said coating in said dosage form, and said active ingredient is peripheral to said coating in said dosage form; or (c) comprising said second pH-adjusting substance surrounded by a membrane, said first pH-adjusting substance being peripheral to said membrane in said dosage form, and said active ingredient is peripheral to said membrane in said dosage form; for use in a method of administering said active ingredient to a mammal through a transmucosal route, said method comprising: a. delivering said active ingredient to a desired site in a body of said mammal; and, sequentially, at said desired site; i. adjusting a localized environment of said active ingredient to promote dissolution of said active ingredient, said step of adjusting said localized environment to promote said dissolution comprising releasing said first portion of said dosage form, whereby said active ingredient attains a first state of dissociation that promotes dissolution; ii. adjusting said localized environment to promote absorption of said active ingredient, said step of adjusting said localized environment to promote said absorption comprising releasing said second portion of said dosage form, whereby said active ingredient attains a second state of dissociation that promotes absorption. (a) being dispersed in a controlled release matrix material, and said first portion of said dosage form includes said active ingredient; or (b) comprising said second pH-adjusting substance surrounded by a coating, said first pH-adjusting substance being peripheral to said coating in said dosage form, and said active ingredient is peripheral to said coating in said dosage form; or (c) comprising said second pH-adjusting substance surrounded by a membrane, said first pH-adjusting substance being peripheral to said membrane in said dosage form, and said active ingredient is peripheral to said membrane in said dosage form; a. delivering said active ingredient to a desired site in a body of said mammal; and, sequentially, at said desired site; i. adjusting a localized environment of said active ingredient to promote dissolution of said active ingredient, said step of adjusting said localized environment to promote said dissolution comprising releasing said first portion of said dosage form, whereby said active ingredient attains a first state of dissociation that promotes dissolution; ii. adjusting said localized environment to promote absorption of said active ingredient, said step of adjusting said localized environment to promote said absorption comprising releasing said second portion of said dosage form, whereby said active ingredient attains a second state of dissociation that promotes absorption. i. adjusting a localized environment of said active ingredient to promote dissolution of said active ingredient, said step of adjusting said localized environment to promote said dissolution comprising releasing said first portion of said dosage form, whereby said active ingredient attains a first state of dissociation that promotes dissolution; ii. adjusting said localized environment to promote absorption of said active ingredient, said step of adjusting said localized environment to promote said absorption comprising releasing said second portion of said dosage form, whereby said active ingredient attains a second state of dissociation that promotes absorption.