A method for single event latch-up - SEL - mitigation, comprising: a) monitoring a plurality of signature vectors for a protected device; b) deriving from the plurality of signature vectors a detected signature which is comprised of a plurality of detected signature vector components; c) comparing the plurality of detected signature vector components to a plurality of previously determined signature vector components; d) based on the comparing step, selectively differentiating between the occurrence of standard current surges associated with normal operation of the protected device and a non-standard current surge which requires cycling power to the protected device for continued proper functioning of the protected device; and e) selectively cycling at least one power bus supplying power to the protected device, based on the results of the comparing step; f) characterized in that the plurality of detected signature vector components include at least two of: i) an operating condition of the protected device from among a plurality of different operating conditions; ii) an operating mode of a host system in which the protected device is installed; iii) a rate of change in a power bus electric current supplied to the protected device; and iv) a current profile of a power bus electric current supplied to the protected device; and g) each signature vector comprised of at least one of iii) and iv) and at least one of i) and ii) signature vector components. a) monitoring a plurality of signature vectors for a protected device; b) deriving from the plurality of signature vectors a detected signature which is comprised of a plurality of detected signature vector components; c) comparing the plurality of detected signature vector components to a plurality of previously determined signature vector components; d) based on the comparing step, selectively differentiating between the occurrence of standard current surges associated with normal operation of the protected device and a non-standard current surge which requires cycling power to the protected device for continued proper functioning of the protected device; and e) selectively cycling at least one power bus supplying power to the protected device, based on the results of the comparing step; f) characterized in that the plurality of detected signature vector components include at least two of: i) an operating condition of the protected device from among a plurality of different operating conditions; ii) an operating mode of a host system in which the protected device is installed; iii) a rate of change in a power bus electric current supplied to the protected device; and iv) a current profile of a power bus electric current supplied to the protected device; and i) an operating condition of the protected device from among a plurality of different operating conditions; ii) an operating mode of a host system in which the protected device is installed; iii) a rate of change in a power bus electric current supplied to the protected device; and iv) a current profile of a power bus electric current supplied to the protected device; and g) each signature vector comprised of at least one of iii) and iv) and at least one of i) and ii) signature vector components.