A compound of Formula I: wherein: W is selected from the group a) H, b) C 1-6 -alkyl that optionally includes 1-3 deuterium atoms, c) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5 and OR 5 Y is C 1-6 -alkyl that optionally may be substituted with OR 5; Z is N; R 1 is selected from the group a) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5, b) C 3-7 -cycloalkyl, c) heterocyclic, and d) aryl; R 2 is C 1-6 -alkyl that optionally may be substituted with NHC R 6, NHSO 2 R 5, NHCOOR 6 and NHR 6; R 3 and R 4 may be the same or different and each is independently selected from the group a) H, and b) C 1-6 -alkyl; R 5 is selected from the group a) H, b) C 1-6 -alkyl, c) NR 7 R 8, and d) aryl; R 6 is selected from the group a) H b) aryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, C OR 5, C NR 7 R 8, aryl, heterocyclyl, C R 9, SO 2 R 5, cyano and CF 3, c) C 1-6 -alkyl that optionally may be substituted with CF 3, SO 2 R 5 and aryl that optionally may be substituted with C 1-6 -alkyl and halogen, d) OR 5, e) NR 7 R 8, f) heteroaryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, aryl and oxo, and g) heterocyclyl; R 7 and R 8 may be the same or different and each is independently selected from the group a) H, b) C 1-6 -alkyl, and c) aryl; and R 9 is selected from the group a) C 1-6 -alkyl, and b) aryl; or a pharmaceutically acceptable salt thereof. W is selected from the group a) H, b) C 1-6 -alkyl that optionally includes 1-3 deuterium atoms, c) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5 and OR 5 a) H, b) C 1-6 -alkyl that optionally includes 1-3 deuterium atoms, c) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5 and OR 5 Y is C 1-6 -alkyl that optionally may be substituted with OR 5; Z is N; R 1 is selected from the group a) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5, b) C 3-7 -cycloalkyl, c) heterocyclic, and d) aryl; a) C 1-6 -alkyl that optionally may be substituted with SO 2 R 5, b) C 3-7 -cycloalkyl, c) heterocyclic, and d) aryl; R 2 is C 1-6 -alkyl that optionally may be substituted with NHC R 6, NHSO 2 R 5, NHCOOR 6 and NHR 6; R 3 and R 4 may be the same or different and each is independently selected from the group a) H, and b) C 1-6 -alkyl; a) H, and b) C 1-6 -alkyl; R 5 is selected from the group a) H, b) C 1-6 -alkyl, c) NR 7 R 8, and d) aryl; a) H, b) C 1-6 -alkyl, c) NR 7 R 8, and d) aryl; R 6 is selected from the group a) H b) aryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, C OR 5, C NR 7 R 8, aryl, heterocyclyl, C R 9, SO 2 R 5, cyano and CF 3, c) C 1-6 -alkyl that optionally may be substituted with CF 3, SO 2 R 5 and aryl that optionally may be substituted with C 1-6 -alkyl and halogen, d) OR 5, e) NR 7 R 8, f) heteroaryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, aryl and oxo, and g) heterocyclyl; a) H b) aryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, C OR 5, C NR 7 R 8, aryl, heterocyclyl, C R 9, SO 2 R 5, cyano and CF 3, c) C 1-6 -alkyl that optionally may be substituted with CF 3, SO 2 R 5 and aryl that optionally may be substituted with C 1-6 -alkyl and halogen, d) OR 5, e) NR 7 R 8, f) heteroaryl that optionally may be substituted with C 1-6 -alkyl, OR 5, halogen, aryl and oxo, and g) heterocyclyl; R 7 and R 8 may be the same or different and each is independently selected from the group a) H, b) C 1-6 -alkyl, and c) aryl; and a) H, b) C 1-6 -alkyl, and c) aryl; and R 9 is selected from the group a) C 1-6 -alkyl, and b) aryl; a) C 1-6 -alkyl, and b) aryl;