A method of determining whether a subject is at risk of developing type 1 diabetes by determining the genetic risk score of a subject by (a) multiplying the score weight of 41 SNPs, if determined in a sample from said subject with the number of risk alleles for each SNP, if determined, wherein the 41 SNPs and their corresponding score weight are selected from the following ones SNP score weight per allele rs1264813 0.43 rs2395029 0.92 rs2476601 0.76 rs2816316 0.16 rs3024505 0.22 rs1990760 0.16 rs3087243 0.16 rs10517086 0.19 rs2069763 0.11 rs6897932 0.19 rs3757247 0.19 rs9388489 0.14 rs6920220 0.15 rs1738074 0.05 rs7804356 0.15 rs4948088 0.17 rs7020673 0.23 rs12722495 0.47 rs947474 0.15 rs10509540 0.25 rs689 or rs 1 004446 0.65 rs4763879 0.06 rs2292239 0.36 rs3184504 0.24 rs1465788 0.13 rs17574546 0.13 rs3825932 0.15 rs12708716 0.15 rs4788084 0.20 rs7202877 0.19 rs2290400 0.25 rs7221109 0.15 rs45450798 0.09 rs763361 0.12 rs425105 0.21 rs2281808 0.07 rs3788013 0.16 rs5753037 0.15 rs229541 0.18 rs5979785 0.09 rs2664170 0.14 and wherein a risk allele is determined by assigning the number 0, if the determined SNP is a non-risk allele, and by assigning the number 1, if the determined SNP is present heterozygously, and by assigning the number 2, if the determined SNP is present homozygously, thereby obtaining multiplication products; (b) assigning the score number 3.15 if SNP rs17426593, SNP rs2187668, and SNP rs7454108 are determined in a subject having a HLA DR4-DQ8/DR4-DQ8 genotype and the score number 3.98 if SNP rs17426593, SNP rs2187668, and SNP rs7454108 are determined in a subject having a HLA DR3/DR4-DQ8 genotype; (c) summing up multiplication products of step a) and the score number of step b), thereby obtaining a genetic risk score; wherein the genetic risk score is indicative that a subject is at risk of developing type 1 diabetes. (a) multiplying the score weight of 41 SNPs, if determined in a sample from said subject with the number of risk alleles for each SNP, if determined, wherein the 41 SNPs and their corresponding score weight are selected from the following ones SNP score weight per allele rs1264813 0.43 rs2395029 0.92 rs2476601 0.76 rs2816316 0.16 rs3024505 0.22 rs1990760 0.16 rs3087243 0.16 rs10517086 0.19 rs2069763 0.11 rs6897932 0.19 rs3757247 0.19 rs9388489 0.14 rs6920220 0.15 rs1738074 0.05 rs7804356 0.15 rs4948088 0.17 rs7020673 0.23 rs12722495 0.47 rs947474 0.15 rs10509540 0.25 rs689 or rs 1 004446 0.65 rs4763879 0.06 rs2292239 0.36 rs3184504 0.24 rs1465788 0.13 rs17574546 0.13 rs3825932 0.15 rs12708716 0.15 rs4788084 0.20 rs7202877 0.19 rs2290400 0.25 rs7221109 0.15 rs45450798 0.09 rs763361 0.12 rs425105 0.21 rs2281808 0.07 rs3788013 0.16 rs5753037 0.15 rs229541 0.18 rs5979785 0.09 rs2664170 0.14 and wherein a risk allele is determined by assigning the number 0, if the determined SNP is a non-risk allele, and by assigning the number 1, if the determined SNP is present heterozygously, and by assigning the number 2, if the determined SNP is present homozygously, thereby obtaining multiplication products; (b) assigning the score number 3.15 if SNP rs17426593, SNP rs2187668, and SNP rs7454108 are determined in a subject having a HLA DR4-DQ8/DR4-DQ8 genotype and the score number 3.98 if SNP rs17426593, SNP rs2187668, and SNP rs7454108 are determined in a subject having a HLA DR3/DR4-DQ8 genotype; (c) summing up multiplication products of step a) and the score number of step b), thereby obtaining a genetic risk score; wherein the genetic risk score is indicative that a subject is at risk of developing type 1 diabetes.