A compound having structural Formula I: and pharmaceutically acceptable salts thereof wherein: -X-R- n2- is and where R is a is -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH 2 OCH 2 - or absent; wherein the -CH 2 - is optionally substituted with 1-2 of -F, and wherein the -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, or -CH 2 OCH 2 - is optionally substituted with 1-3 of -F; and wherein a forms a bridge between two non-adjacent carbons; R5 is-H, -F with the proviso that -F is not attached to a carbon also bonded to nitrogen, -CH 3, - CF 3, -CHF 2, -CH 2 F, or -CH 2 OH, or R 5 represents di-substitution on a single carbon with two of -F with the proviso that the two -F are not attached to a carbon also bonded to nitrogen, or two of -CH 3; R6 and R 7 are individually either -H, -C 1-3 alkyl optionally substituted with 1-3 of -F, or together they form C 1-3 cycloalkyl optionally substituted with 1-3 of -F; R 8 is -H, -F, -CH 3, -CF 3, -CHF 2, -CH 2 F, or -CH 2 OH, or phenyl optionally substituted with 1-3 of -F or -C 1-3 alkyl; n1 and n2 can be individually either 0 or 1; Z 1 is: and Z 2 is or Z 2 is: and Z 1 or Z 1 and Z 2 is one of W 1 and W 2 is N and the other is CH; R 1 and R 2 are each independently -H, -F, -Cl, -Br, cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; one of R 3a and R 3b is -CN, tetrazolyl, or -S 2 C alkyl and the other is -H, -F, -Cl, -Br, -S-CH3, -NH-CH 3, -O-cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; one of R 4a and R 4b is -CN, tetrazolyl, or -S 2 C alkyl and the other is -H, -F, -Cl, -Br, -S-CH3, -NH-CH 3, -O-cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; R a, R aa, R b and R bb are each independently -H, -F, -Cl, -C 1-3 alkyl optionally substituted with 1 to 3 of -F, or -OC 1-3 alkyl optionally substituted with 1 to 3 of -F; R c and R d are each independently -H, -F, -Cl, -C 1-3 alkyl optionally substituted with 1 to 3 of - F, or -OC 1-3 alkyl optionally substituted with 1 to 3 of -F; X is absent or C 1 alkyl having 2 substituents independently -H, or -C 1-3 alkyl optionally substituted with 1 to 3 of -F, wherein two -C 1-3 alkyl substituents together may form a -C 3-6 cycloalkyl on the C 1 alkyl; and one of Y 1 or Y 2 is -CH -; and the other is -CH -; -S 2 -; -S 2 CH 2 -; -CH 2 - wherein - CH 2 - is optionally substituted with -C 1-3 alkyl optionally substituted with -OH, -OC 1-3 alkyl, or - 1-3 of -F, or absent; provided that where Y 1 or Y 2 is -S 2 - or -S 2 CH 2 -, then the adjacent n1 or n2, respectively, is 0; and provided further that where Y 1 or Y 2 is -CH -, then the adjacent n1 or n2, respectively, is 1. -X-R- n2- is and where R is a is -CH 2 -, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, -CH 2 OCH 2 - or absent; wherein the -CH 2 - is optionally substituted with 1-2 of -F, and wherein the -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, or -CH 2 OCH 2 - is optionally substituted with 1-3 of -F; and wherein a forms a bridge between two non-adjacent carbons; R5 is-H, -F with the proviso that -F is not attached to a carbon also bonded to nitrogen, -CH 3, - CF 3, -CHF 2, -CH 2 F, or -CH 2 OH, or R 5 represents di-substitution on a single carbon with two of -F with the proviso that the two -F are not attached to a carbon also bonded to nitrogen, or two of -CH 3; R6 and R 7 are individually either -H, -C 1-3 alkyl optionally substituted with 1-3 of -F, or together they form C 1-3 cycloalkyl optionally substituted with 1-3 of -F; R 8 is -H, -F, -CH 3, -CF 3, -CHF 2, -CH 2 F, or -CH 2 OH, or phenyl optionally substituted with 1-3 of -F or -C 1-3 alkyl; n1 and n2 can be individually either 0 or 1; Z 1 is: and Z 2 is or Z 2 is: and Z 1 or Z 1 and Z 2 is one of W 1 and W 2 is N and the other is CH; R 1 and R 2 are each independently -H, -F, -Cl, -Br, cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; one of R 3a and R 3b is -CN, tetrazolyl, or -S 2 C alkyl and the other is -H, -F, -Cl, -Br, -S-CH3, -NH-CH 3, -O-cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; one of R 4a and R 4b is -CN, tetrazolyl, or -S 2 C alkyl and the other is -H, -F, -Cl, -Br, -S-CH3, -NH-CH 3, -O-cyclopropyl, -C 1-3 alkyl optionally substituted with 1-3 of -F, or -OC 1-3 alkyl optionally substituted with 1-3 of -F; R a, R aa, R b and R bb are each independently -H, -F, -Cl, -C 1-3 alkyl optionally substituted with 1 to 3 of -F, or -OC 1-3 alkyl optionally substituted with 1 to 3 of -F; R c and R d are each independently -H, -F, -Cl, -C 1-3 alkyl optionally substituted with 1 to 3 of - F, or -OC 1-3 alkyl optionally substituted with 1 to 3 of -F; X is absent or C 1 alkyl having 2 substituents independently -H, or -C 1-3 alkyl optionally substituted with 1 to 3 of -F, wherein two -C 1-3 alkyl substituents together may form a -C 3-6 cycloalkyl on the C 1 alkyl; and one of Y 1 or Y 2 is -CH -; and the other is -CH -; -S 2 -; -S 2 CH 2 -; -CH 2 - wherein - CH 2 - is optionally substituted with -C 1-3 alkyl optionally substituted with -OH, -OC 1-3 alkyl, or - 1-3 of -F, or absent; provided that where Y 1 or Y 2 is -S 2 - or -S 2 CH 2 -, then the adjacent n1 or n2, respectively, is 0; and provided further that where Y 1 or Y 2 is -CH -, then the adjacent n1 or n2, respectively, is 1.