A method of operating a wireless data network to serve wireless User Equipment,UE, that executes a downlink-centric client application and that executes an uplink-centric server application, the method comprising: Distributed Unit,DU, circuitry wirelessly receiving Uplink,UL, client data transferred from the downlink-centric client application and executing a DU UL Physical Module,PHY, DU UL Media Access Control Module,MAC, DU UL Radio Link Control Module,RLC, DU UL Packet Data Convergence Protocol Module,PDCP, and DU UL Radio Resource Control Module,RRC, and responsively transferring the UL client data for delivery to Central Unit,CU, circuitry; the CU circuitry receiving the UL client data for the downlink-centric client application and transferring the UL client data for delivery to a network core; the CU circuitry receiving Downlink, DL, client data transferred from the network core for delivery to the downlink-centric client application and executing a CU DL RRC, CU DL PDCP, CU DL RLC, and CU DL MAC and responsively transferring the DL client data for delivery to the DU circuitry; the DU circuitry receiving the DL client data for the downlink-centric client application and executing a DU DL Hybrid Automatic Repeat Request Module,HARQ, of a DU DL MAC and a DU DL PHY and responsively wirelessly transferring the DL client data to the wireless UE for delivery to the downlink-centric client application; the DU circuitry wirelessly receiving UL server data transferred from the uplink-centric server application and executing the DU UL PHY and a DU UL HARQ portion of the DU UL MAC and responsively transferring the UL server data for delivery to the CU circuitry; the CU circuitry receiving the UL server data for the uplink-centric server application and executing a CU UL MAC, CU UL RLC, CU UL PDCP, and CU UL RRC and responsively transferring the UL server data for delivery to the network core; the CU circuitry receiving DL server data transferred from the network core for delivery to the uplink-centric server application and transferring the DL server data for delivery to the DU circuitry; and the DU circuitry receiving the DL server data for the uplink-centric server application and executing a DU DL RRC, DU DL PDCP, DU DL RLC, the DU DL MAC, and the DU DL PHY and responsively wirelessly transferring the DL server data to the wireless UE for delivery to the uplink-centric server application. Distributed Unit,DU, circuitry wirelessly receiving Uplink,UL, client data transferred from the downlink-centric client application and executing a DU UL Physical Module,PHY, DU UL Media Access Control Module,MAC, DU UL Radio Link Control Module,RLC, DU UL Packet Data Convergence Protocol Module,PDCP, and DU UL Radio Resource Control Module,RRC, and responsively transferring the UL client data for delivery to Central Unit,CU, circuitry; the CU circuitry receiving the UL client data for the downlink-centric client application and transferring the UL client data for delivery to a network core; the CU circuitry receiving Downlink, DL, client data transferred from the network core for delivery to the downlink-centric client application and executing a CU DL RRC, CU DL PDCP, CU DL RLC, and CU DL MAC and responsively transferring the DL client data for delivery to the DU circuitry; the DU circuitry receiving the DL client data for the downlink-centric client application and executing a DU DL Hybrid Automatic Repeat Request Module,HARQ, of a DU DL MAC and a DU DL PHY and responsively wirelessly transferring the DL client data to the wireless UE for delivery to the downlink-centric client application; the DU circuitry wirelessly receiving UL server data transferred from the uplink-centric server application and executing the DU UL PHY and a DU UL HARQ portion of the DU UL MAC and responsively transferring the UL server data for delivery to the CU circuitry; the CU circuitry receiving the UL server data for the uplink-centric server application and executing a CU UL MAC, CU UL RLC, CU UL PDCP, and CU UL RRC and responsively transferring the UL server data for delivery to the network core; the CU circuitry receiving DL server data transferred from the network core for delivery to the uplink-centric server application and transferring the DL server data for delivery to the DU circuitry; and the DU circuitry receiving the DL server data for the uplink-centric server application and executing a DU DL RRC, DU DL PDCP, DU DL RLC, the DU DL MAC, and the DU DL PHY and responsively wirelessly transferring the DL server data to the wireless UE for delivery to the uplink-centric server application.