Quinolinecarboxamide compounds of general formula I wherein R 1 and R 2 are independently selected from the group consisting of H, D, and F, R 3 is selected from the group consisting of H, D, and C1-C5 alkyl, R 4 and R 5 are independently selected from the group consisting of H, D, -OH, C1-C3 alkoxy and a structure -X-Y-Z, wherein X is oxygen or -NH-, Y is or or wherein k is an integer from 5 to 15 and m is an integer from 1 to 3, and Z is or or R 6 is selected from the group consisting of H, D, C1-C10 alkyl, C3-C10 cycloalkyl, adamantyl, and substituted or unsubstituted aryl or C7-C20 alkylaryl, wherein the aryl is wherein R 7 and R 11 are independently selected from the group consisting of H, D, halogen, C1-C3 alkyl, C1-C3 alkoxy, -CF 3, and -C(=O)-OR 12, wherein R 12 is selected from the group consisting of H, D, halogen, and C1-C4 alkyl or C1-C2 alkyl, R 8, R 9 and R 10 are independently selected from the group consisting of H, D, halogen, -OMe, C1-C3 alkyl, C1-C3 alkoxy or C1-C2 alkoxy, -CF 3, and -C(=O)-OR 12, or R 6 is or wherein R 13 is selected from the group consisting of -OR 12, -NHR 12, -N(-CH 3)R 12, pyrrolidine, and morpholine, R 14 and R 15 are independently selected from the group consisting of H, D, C1-C5 alkyl, phenyl, 3,4-dimethoxyphenyl, benzyl, 3,4-dimethoxybenzyl, and unsubstituted C3-C8 heteroalkylaryl, R 16 and R 17 are independently selected from the group consisting of H, D, C1-C6 alkyl, phenyl, benzyl, 4-hydroxybenzyl, unsubstituted C3-C8 heteroalkylaryl, -(CH 2) n C(=O)-OR 18, -(CH 2) n -C(=O)-NR 19 R 20, and -(CH 2) n NR 21 R 22, wherein n is an integer from 1 to 4, R 18 is selected from the group consisting of H, D, C1-C3 alkyl, and benzyl, R 19 and R 20 are independently selected from the group consisting of H, D, C1-C3 alkyl, benzyl, and 3,4-dimethoxybenzyl, and R 21 and R 22 are independently selected from the group consisting of H, D, and (benzyloxy)carbonyl. wherein R 1 and R 2 are independently selected from the group consisting of H, D, and F, R 3 is selected from the group consisting of H, D, and C1-C5 alkyl, R 4 and R 5 are independently selected from the group consisting of H, D, -OH, C1-C3 alkoxy and a structure -X-Y-Z, wherein X is oxygen or -NH-, Y is or or wherein k is an integer from 5 to 15 and m is an integer from 1 to 3, and Z is or or R 6 is selected from the group consisting of H, D, C1-C10 alkyl, C3-C10 cycloalkyl, adamantyl, and substituted or unsubstituted aryl or C7-C20 alkylaryl, wherein the aryl is wherein R 7 and R 11 are independently selected from the group consisting of H, D, halogen, C1-C3 alkyl, C1-C3 alkoxy, -CF 3, and -C(=O)-OR 12, wherein R 12 is selected from the group consisting of H, D, halogen, and C1-C4 alkyl or C1-C2 alkyl, R 8, R 9 and R 10 are independently selected from the group consisting of H, D, halogen, -OMe, C1-C3 alkyl, C1-C3 alkoxy or C1-C2 alkoxy, -CF 3, and -C(=O)-OR 12, wherein R 7 and R 11 are independently selected from the group consisting of H, D, halogen, C1-C3 alkyl, C1-C3 alkoxy, -CF 3, and -C(=O)-OR 12, wherein R 12 is selected from the group consisting of H, D, halogen, and C1-C4 alkyl or C1-C2 alkyl, R 8, R 9 and R 10 are independently selected from the group consisting of H, D, halogen, -OMe, C1-C3 alkyl, C1-C3 alkoxy or C1-C2 alkoxy, -CF 3, and -C(=O)-OR 12, or R 6 is or wherein R 13 is selected from the group consisting of -OR 12, -NHR 12, -N(-CH 3)R 12, pyrrolidine, and morpholine, R 14 and R 15 are independently selected from the group consisting of H, D, C1-C5 alkyl, phenyl, 3,4-dimethoxyphenyl, benzyl, 3,4-dimethoxybenzyl, and unsubstituted C3-C8 heteroalkylaryl, R 16 and R 17 are independently selected from the group consisting of H, D, C1-C6 alkyl, phenyl, benzyl, 4-hydroxybenzyl, unsubstituted C3-C8 heteroalkylaryl, -(CH 2) n C(=O)-OR 18, -(CH 2) n -C(=O)-NR 19 R 20, and -(CH 2) n NR 21 R 22, wherein n is an integer from 1 to 4, R 18 is selected from the group consisting of H, D, C1-C3 alkyl, and benzyl, R 19 and R 20 are independently selected from the group consisting of H, D, C1-C3 alkyl, benzyl, and 3,4-dimethoxybenzyl, and R 21 and R 22 are independently selected from the group consisting of H, D, and (benzyloxy)carbonyl. wherein R 13 is selected from the group consisting of -OR 12, -NHR 12, -N(-CH 3)R 12, pyrrolidine, and morpholine, R 14 and R 15 are independently selected from the group consisting of H, D, C1-C5 alkyl, phenyl, 3,4-dimethoxyphenyl, benzyl, 3,4-dimethoxybenzyl, and unsubstituted C3-C8 heteroalkylaryl, R 16 and R 17 are independently selected from the group consisting of H, D, C1-C6 alkyl, phenyl, benzyl, 4-hydroxybenzyl, unsubstituted C3-C8 heteroalkylaryl, -(CH 2) n C(=O)-OR 18, -(CH 2) n -C(=O)-NR 19 R 20, and -(CH 2) n NR 21 R 22, wherein n is an integer from 1 to 4, R 18 is selected from the group consisting of H, D, C1-C3 alkyl, and benzyl, R 19 and R 20 are independently selected from the group consisting of H, D, C1-C3 alkyl, benzyl, and 3,4-dimethoxybenzyl, and R 21 and R 22 are independently selected from the group consisting of H, D, and (benzyloxy)carbonyl.