An Electrostatic Discharge protection circuit, comprising: a clamp circuit, coupled between an Electrostatic Discharge bus and a ground node (NVSS); a switch element, coupled between a supply node (NVDD) and the Electrostatic Discharge bus; and a detection circuit, detecting whether an Electrostatic Discharge event occurs on the Electrostatic Discharge bus; wherein when the Electrostatic Discharge event does not occur, the detection circuit closes the switch element such that the Electrostatic Discharge bus is coupled to the supply node (NVDD), and when the Electrostatic Discharge event occurs, the detection circuit opens the switch element such that the Electrostatic Discharge bus is decoupled from the supply node (NVDD); wherein the detection circuit comprises: a first resistor, coupled between the Electrostatic Discharge bus and a median node; a second resistor, coupled between the median node and the ground node (NVSS); a third transistor, wherein the third transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the median node, and a second terminal coupled to a first node; and a fourth transistor, wherein the fourth transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the Electrostatic Discharge bus, and a second terminal coupled to the first node; and wherein the first node is connected to the control terminal of the switch element. a clamp circuit, coupled between an Electrostatic Discharge bus and a ground node (NVSS); a switch element, coupled between a supply node (NVDD) and the Electrostatic Discharge bus; and a detection circuit, detecting whether an Electrostatic Discharge event occurs on the Electrostatic Discharge bus; wherein when the Electrostatic Discharge event does not occur, the detection circuit closes the switch element such that the Electrostatic Discharge bus is coupled to the supply node (NVDD), and when the Electrostatic Discharge event occurs, the detection circuit opens the switch element such that the Electrostatic Discharge bus is decoupled from the supply node (NVDD); wherein the detection circuit comprises: a first resistor, coupled between the Electrostatic Discharge bus and a median node; a second resistor, coupled between the median node and the ground node (NVSS); a third transistor, wherein the third transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the median node, and a second terminal coupled to a first node; and a fourth transistor, wherein the fourth transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the Electrostatic Discharge bus, and a second terminal coupled to the first node; and wherein the first node is connected to the control terminal of the switch element. a first resistor, coupled between the Electrostatic Discharge bus and a median node; a second resistor, coupled between the median node and the ground node (NVSS); a third transistor, wherein the third transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the median node, and a second terminal coupled to a first node; and a fourth transistor, wherein the fourth transistor has a control terminal coupled to the supply node (NVDD), a first terminal coupled to the Electrostatic Discharge bus, and a second terminal coupled to the first node; and wherein the first node is connected to the control terminal of the switch element.