mhurhangee/ep-ind-claims huggingface dataset:
A process for producing a high purity degree 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamide compound selected from -2-[4-(3-fluorobenzyloxy)benzylamino]propanamide (safinamide) of formula ( Ia), -2-[4-(2-fluorobenzyloxy)benzylamino]propanamide (ralfinamide) of formula ( Ib) the respective R-enantiomers ( I'a) and ( I'b), the respective racemic mixtures ( Ia, I'a) and ( Ib, I'b) and the salts thereof with pharmaceutically acceptable acids wherein safinamide ( Ia), ralfinamide ( Ib), the respective R-enantiomer ( I'a) or ( I'b), or the respective racemic mixture ( Ia, I'a) and ( Ib, I'b) or a salt thereof with a pharmaceutically acceptable acid has a content of the respective impurity, -2-[3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)-benzylamino]propanamide ( IIa), -2-[3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)-benzylamino]propanamide ( IIb), the respective R-enantiomer ( II'a) or ( II'b), or the respective racemic mixture ( IIa, II'a) or ( IIb, II'b) or a salt thereof with a pharmaceutically acceptable acid, which is lower than 0.03%, (by weight), characterized in that a Schiff base intermediate of formula ( IIIa), ( IIIb) the respective R-enantiomer ( III'a) or ( III'b) or the respective racemic mixture ( IIIa, III'a) or ( IIIb, III'b) (i) is obtained by an iminoalkylation reaction of 4-(3- or 2-fluorobenzyloxy)benzaldehyde with L-alaminamide or D-alaninamide or their racemic mixture, without any addition of molecular sieves, in a solvent selected from (C 1 -C 5) lower alkanols at a temperature between 20°C and 30°C in an amount of such solvent with respect to the aldehyde which allows formation of a suspension of the Schiff base in a saturated solution of the Schiff base in the same solvent, and (ii), after completion of the iminoalkylation reaction is submitted to a reduction reaction with a reducing agent selected from sodium borohydride and potassium borohydride in a selected amount of an organic solvent chosen from (C 1 -C 5) lower alkanols or a mixture thereof, optionally with a small amount water, wherein the ratio of the organic solvent to the Schiff base allows the formation and the presence during a substantial portion of the reduction reaction course of a suspension of the Schiff base into the saturated solution of the Schiff base in the same organic solvent and ranges from 0.5L to 3.0Lper each mole of Schiff base, the process being further characterized in that the 4-(3- or 2-fluorobenzyloxy)benzaldehyde starting material ( IVa) or ( IVb) employed for the preparation of the Schiff base intermediate ( IIIa), ( IIIb), ( III'a), ( III'b) or the respective racemic mixture ( IIIa, III'a) or ( IIIb, III'b) has a content of 3-(3- or 2-fluorobenzyl)-4-(3- or 2-fluorobenzyloxy)benzaldehyde impurity ( VIa) or ( VIb) lower than 0.03%, whereby safinamide ( Ia), ralfinamide ( Ib), the respective R-enantiomer ( I'a) or ( I'b) or the respective racemic mixture ( Ia, I'a) or ( Ib, I'b) is obtained in a free base form and, optionally said free base form is converted in a salt thereof with a pharmaceutically acceptable acid.
A bispecific antibody, comprising: a first antigen-binding portion which specifically binds to WT1/HLA, comprising: a heavy chain variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46; or a VH and VL comprising first and second amino acid sequences, respectively, from SEQ ID NOS: 50 and 52; or SEQ ID NO: 54; and a second antigen-binding portion which specifically binds to CD3. a first antigen-binding portion which specifically binds to WT1/HLA, comprising: a heavy chain variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46; or a VH and VL comprising first and second amino acid sequences, respectively, from SEQ ID NOS: 50 and 52; or SEQ ID NO: 54; and a heavy chain variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46; or a VH and VL comprising first and second amino acid sequences, respectively, from SEQ ID NOS: 50 and 52; or SEQ ID NO: 54; and a second antigen-binding portion which specifically binds to CD3.
A lipid particle comprising: (i) at least one cationic and/or pH responsive lipid, (ii) at least one water-soluble therapeutically effective compound which is useful in immunotherapy, and (iii) RNA encoding at least one antigen, wherein the antigen is preferably a disease-associated antigen or elicits an immune response against a disease-associated antigen or cells expressing a disease-associated antigen, wherein the particle comprises a lamellar organization comprising 2 to 40 lamellae per row, and wherein the water-soluble therapeutically effective compound which is useful in immunotherapy is a bisphosphonate that stimulates γδ T cells. (i) at least one cationic and/or pH responsive lipid, (ii) at least one water-soluble therapeutically effective compound which is useful in immunotherapy, and (iii) RNA encoding at least one antigen, wherein the antigen is preferably a disease-associated antigen or elicits an immune response against a disease-associated antigen or cells expressing a disease-associated antigen, wherein the particle comprises a lamellar organization comprising 2 to 40 lamellae per row, and wherein the water-soluble therapeutically effective compound which is useful in immunotherapy is a bisphosphonate that stimulates γδ T cells.
An epoxy-containing, isocyanurate-modified silicone resin comprising recurring units having the formulae to: wherein R 1 to R 7 are each independently hydrogen or a monovalent organic group, at least one of R 5 to R 7 being an epoxy-containing organic group, a1, a2, b1, b2, c1 and c2 are numbers in the range: 0 ≤ a1 ≤ 0.6, 0 ≤ a2 ≤ 0.8, 0 ≤ b1 ≤ 0.6, 0 ≤ b2 ≤ 0.8, 0 ≤ c1 ≤ 0.6, 0.2 ≤ c2 ≤ 0.8, 0.2 ≤ a2+b2 ≤ 0.8, 0.4 ≤ a2+b2+c2 ≤ 1, and a1+a2+b1+b2+c1+c2 = 1, d is an integer of 0 to 300, e and f are integers in the range: 0 ≤ e ≤ 300, 0 ≤ f ≤ 300, and 0 ≤ e+f ≤ 300, X 1 is a divalent group having the formula: wherein R 8 is each independently hydrogen or methyl, j and k are each independently an integer of 0 to 7, p is an integer of 0 to 300, X 2 is a divalent group having the formula: wherein R 9 is each independently hydrogen or methyl, R 10 is a C 1 -C 8 alkyl, allyl, glycidyl or C 6 -C 10 aryl group, q and r are each independently an integer of 0 to 7. a1, a2, b1, b2, c1 and c2 are numbers in the range: 0 ≤ a1 ≤ 0.6, 0 ≤ a2 ≤ 0.8, 0 ≤ b1 ≤ 0.6, 0 ≤ b2 ≤ 0.8, 0 ≤ c1 ≤ 0.6, 0.2 ≤ c2 ≤ 0.8, 0.2 ≤ a2+b2 ≤ 0.8, 0.4 ≤ a2+b2+c2 ≤ 1, and a1+a2+b1+b2+c1+c2 = 1, d is an integer of 0 to 300, e and f are integers in the range: 0 ≤ e ≤ 300, 0 ≤ f ≤ 300, and 0 ≤ e+f ≤ 300, X 1 is a divalent group having the formula: wherein R 8 is each independently hydrogen or methyl, j and k are each independently an integer of 0 to 7, p is an integer of 0 to 300, X 2 is a divalent group having the formula: wherein R 9 is each independently hydrogen or methyl, R 10 is a C 1 -C 8 alkyl, allyl, glycidyl or C 6 -C 10 aryl group, q and r are each independently an integer of 0 to 7.
A blood processing system comprising a durable, reusable assembly comprises a controller, and a disposable, sealed and sterile fluid flow circuit, wherein the fluid flow circuit comprises a replacement fluid flow conduit, characterized in that the durable assembly comprises a citrate detector and a flow detector, wherein the citrate detector comprises: a light source configured to emit a light toward and into the replacement fluid flow conduit, the light having a wavelength absorbed by citrate, but at least partially transmitted by the replacement fluid flow conduit; and a light detector configured to receive at least a portion of the light from the light source exiting the replacement fluid flow conduit and generate a signal indicative of the presence or absence of citrate in the replacement fluid flow conduit based, at least in part, on the amount of light received by the light detector, wherein the controller is configured to receive the signal from the light detector and determine whether citrate is present in the replacement fluid flow conduit based, at least in part, on the signal from the light detector, preferably by comparison of the signal to a baseline value, wherein the flow detector is configured to determine the presence of fluid in the replacement fluid conduit. a light source configured to emit a light toward and into the replacement fluid flow conduit, the light having a wavelength absorbed by citrate, but at least partially transmitted by the replacement fluid flow conduit; and a light detector configured to receive at least a portion of the light from the light source exiting the replacement fluid flow conduit and generate a signal indicative of the presence or absence of citrate in the replacement fluid flow conduit based, at least in part, on the amount of light received by the light detector, wherein the controller is configured to receive the signal from the light detector and determine whether citrate is present in the replacement fluid flow conduit based, at least in part, on the signal from the light detector, preferably by comparison of the signal to a baseline value,
Electrical equipment comprising: a main body portion; a battery disposed in the main body portion; an operating unit which operates by electric power supply from the battery; a handle that is a human body contacting portion which a user contacts in gripping the handle when the electrical equipment is used; a conductive member at least a part of which is disposed in the handle and is exposed outside the handle, and a circuit board having a predetermined pattern, characterized in that the conductive member or a pattern connected to the conductive member electrically and the predetermined pattern of the circuit board are disposed so as to face each other. a main body portion; a battery disposed in the main body portion; an operating unit which operates by electric power supply from the battery; a handle that is a human body contacting portion which a user contacts in gripping the handle when the electrical equipment is used; a conductive member at least a part of which is disposed in the handle and is exposed outside the handle, and a circuit board having a predetermined pattern, characterized in that the conductive member or a pattern connected to the conductive member electrically and the predetermined pattern of the circuit board are disposed so as to face each other.
Storage device having a flat, in particular rectangular, shelf having side edges, a flap fastening device (11, 12, 31) for pivotably mounting a flap on the flat, in particular rectangular, shelf having side edges, wherein the flap fastening device (11, 12, 31) is made in one piece and has a fastening device (14, 32), with which the flap fastening device (11, 12, 31) is snapped onto the side edge of the shelf, and a mounting device, by means of which the flap is pivotably mounted relative to the shelf, and a flap pivotably mounted relative to the shelf by means of the flap fastening device (11, 12, 31), wherein the flap fastening device (11, 12, 31) is an attachment mounted on the shelf, characterised in that the fastening device (14, 32) is designed to be U-shaped and has an upper wall, a lower wall (14b, 32b) and a rear wall (14c, 32c) which form a groove, the width of which is adapted to the thickness of the shelf, such that the flap fastening device (11, 12, 31) snapped onto the side edges is fitted onto the side edge by force-fit.
Method for controlling the brake force in an electrohydraulic brake system of a motor vehicle, comprising the steps: a) initiating a brake operation, b) detecting a current state of the electrohydraulic brake system, c) increasing the brake pressure in a manner which is dependent on the current state of the electrohydraulic brake system, characterized in that a targeted brake pressure supply, taking place at different times from one another, of individual parts of the brake system takes place, wherein the targeted brake pressure supply, taking place at different times from one another, of individual parts of the brake system takes place in an alternating manner. a) initiating a brake operation, b) detecting a current state of the electrohydraulic brake system, c) increasing the brake pressure in a manner which is dependent on the current state of the electrohydraulic brake system, in that a targeted brake pressure supply, taking place at different times from one another, of individual parts of the brake system takes place, wherein the targeted brake pressure supply, taking place at different times from one another, of individual parts of the brake system takes place in an alternating manner.
A platform configured for reducing vibrations, comprising: - a table plate configured with a top surface to hold equipment; - an inner base frame comprising at least two opposing first side elements; - an outer base frame comprising at least two opposing second side elements; - at least two first vibration reducing elements connecting the table plate to the inner base frame; and - at least two second vibration reducing elements connecting the inner base frame to the outer base frame, wherein each of said second vibration reducing elements is connected in-between each of said opposing first side elements and each of said opposing second side elements, and wherein each of said second vibration reducing elements is made of two elastic materials: - the first elastic material having a first elastic property, and characterized in that - the second elastic material having a second elastic property that differs from the first elastic property, wherein the two elastic materials are displaced laterally from each other, such that the two elastic materials are placed in two layers in-between each of said opposing first side elements and each of said opposing second side elements, and wherein each of the first vibration reducing elements is a suspension element configured to suspend the table plate from the inner base frame. - a table plate configured with a top surface to hold equipment; - an inner base frame comprising at least two opposing first side elements; - an outer base frame comprising at least two opposing second side elements; - at least two first vibration reducing elements connecting the table plate to the inner base frame; and - at least two second vibration reducing elements connecting the inner base frame to the outer base frame, wherein each of said second vibration reducing elements is connected in-between each of said opposing first side elements and each of said opposing second side elements, and wherein each of said second vibration reducing elements is made of two elastic materials: - the first elastic material having a first elastic property, and characterized in that - the second elastic material having a second elastic property that differs from the first elastic property, - the first elastic material having a first elastic property, and characterized in that - the second elastic material having a second elastic property that differs from the first elastic property, wherein the two elastic materials are displaced laterally from each other, such that the two elastic materials are placed in two layers in-between each of said opposing first side elements and each of said opposing second side elements, and wherein each of the first vibration reducing elements is a suspension element configured to suspend the table plate from the inner base frame.
An adhesion promoter system comprising an aqueous dispersion comprising the melt kneading product of: at least 60 percent by weight of a first functionalized polyolefin, based on the total weight of the solid content, wherein the first functionalized polyolefin is an amine and/or hydroxyl functionalized polyolefin prepared via an in-situ melt reaction; optionally from 0.5 to less than 40 percent by weight of a second functionalized polyolefin, based on the total weight of the solid content, wherein said second functionalized polyolefin comprises homopolymers of propylene or copolymers of propylene with hexene, octene and/or other like alpha-olefins, the homopolymers or copolymers having a single unsaturation, a terminal succinic anhydride moiety, and additional succinic anhydride substitutions on the polypropylene backbone, where the succinic anhydride substitution ranges from about 5 to about 45 weight percent of functionalized polymer composition; from 0.1 to less than 20 percent by weight of a stabilizing agent, based on the total weight of the solid content; and in the presence of water and optionally one or more neutralizing agents; and wherein said dispersion has an average particle size diameter in the range of from 0.05 to 5 μm, and a pH in the range of from 8 to 11. at least 60 percent by weight of a first functionalized polyolefin, based on the total weight of the solid content, wherein the first functionalized polyolefin is an amine and/or hydroxyl functionalized polyolefin prepared via an in-situ melt reaction; optionally from 0.5 to less than 40 percent by weight of a second functionalized polyolefin, based on the total weight of the solid content, wherein said second functionalized polyolefin comprises homopolymers of propylene or copolymers of propylene with hexene, octene and/or other like alpha-olefins, the homopolymers or copolymers having a single unsaturation, a terminal succinic anhydride moiety, and additional succinic anhydride substitutions on the polypropylene backbone, where the succinic anhydride substitution ranges from about 5 to about 45 weight percent of functionalized polymer composition; from 0.1 to less than 20 percent by weight of a stabilizing agent, based on the total weight of the solid content; and in the presence of water and optionally one or more neutralizing agents; and wherein said dispersion has an average particle size diameter in the range of from 0.05 to 5 μm, and a pH in the range of from 8 to 11.
A method comprising: Interfacing a hardware token with a computer host, the hardware token comprising security software and communication software stored thereon, the security software being stored in a memory of the hardware token, the computer host comprising a memory distinct from the hardware token memory; on the hardware token, determining an authenticity of the security software; upon successful validation of the authenticity of the security software on the hardware token, determining an authenticity of the communication software by loading the security software from the hardware token memory into the computer host memory and executing the loaded security software from the computer host memory; and after successful validation of the authenticity of the communication software, facilitating communication, via the computer host, between the hardware token and a remote computer remote from the computer host, by executing the communication software from the computer host memory. Interfacing a hardware token with a computer host, the hardware token comprising security software and communication software stored thereon, the security software being stored in a memory of the hardware token, the computer host comprising a memory distinct from the hardware token memory; on the hardware token, determining an authenticity of the security software; upon successful validation of the authenticity of the security software on the hardware token, determining an authenticity of the communication software by loading the security software from the hardware token memory into the computer host memory and executing the loaded security software from the computer host memory; and after successful validation of the authenticity of the communication software, facilitating communication, via the computer host, between the hardware token and a remote computer remote from the computer host, by executing the communication software from the computer host memory.
A laminating adhesive comprising: a polyisocyanate component that does not contain a derivative of isophorone diisocyanate, and a polyol component, wherein the polyisocyanate component contains a polyisocyanate that does not contain an aromatic ring, and the polyol component contains a macropolyol that does not contain an aromatic ring but contains a cyclohexane ring, which macropolyol is a polyurethane polyol (B1-1') obtained by reaction of a crystalline polyol (B1-1a') that does not contain an aromatic ring and is crystalline at normal temperature with a polyisocyanate (B1-1b) that does not contain an aromatic ring but contains a cyclohexane ring; and wherein the crystalline polyol (B1-1a') contains a crystalline polycarbonate diol that is crystalline at normal temperature. a polyisocyanate component that does not contain a derivative of isophorone diisocyanate, and a polyol component, wherein the polyisocyanate component contains a polyisocyanate that does not contain an aromatic ring, and the polyol component contains a macropolyol that does not contain an aromatic ring but contains a cyclohexane ring, which macropolyol is a polyurethane polyol (B1-1') obtained by reaction of a crystalline polyol (B1-1a') that does not contain an aromatic ring and is crystalline at normal temperature with a polyisocyanate (B1-1b) that does not contain an aromatic ring but contains a cyclohexane ring; and wherein the crystalline polyol (B1-1a') contains a crystalline polycarbonate diol that is crystalline at normal temperature.
A handheld abrading machine comprising a holding device for holding the abrading machine, a drive motor and a tool head, wherein the holding device comprises a substantially tubular bar which has a proximal end and a distal end, wherein the drive motor is arranged at the proximal end, wherein the tool head is arranged at the distal end, wherein the abrading machine comprises a transmission shaft which connects the drive motor to a tool holder of the tool head for transmitting torque thereto and which runs at least in sections thereof within the tubular bar, wherein the abrading machine comprises a suction device which comprises a suction channel which has a substantially ring-shaped or ring-section-shaped suction channel section, wherein the tool holder and an end of the transmission shaft towards the tool holder are connected to one another by means of a planetary gear, characterized in that the substantially ring-shaped or ring-section-shaped suction channel section surrounds a coupling device for coupling the transmission shaft to the tool holder at least in sections thereof, the substantially ring-shaped or ring-section-shaped suction channel section surrounds a gear unit for coupling the transmission shaft to the tool holder at least in sections thereof and at least approximately concentrically, and an interior space of the tubular bar is formed in two parts, wherein an interior space part of the interior space forms a suction channel section of the suction channel of the suction device and a further interior space part of the interior space of the tubular bar serves for accommodating and/or guiding the transmission shaft.