mhurhangee/ep-ind-claims huggingface dataset:
A method for determining the likelihood of effectiveness of an EGFR tyrosine kinase inhibitor to treat cancer in a patient affected with cancer, comprising determining whether the erbB1 gene of said patient comprises at least one nucleic acid variance, wherein the variance is selected from: a. a mutation in exon 18 that results in a substitution of cysteine for glycine at codon 719 of SEQ. ID. NO: 511 (G719C) or in a substitution of serine for glycine at codon 719 of SEQ. ID. NO: 511 (G719S); or b. an in-frame deletion in exon 19 that results in a deletion of at least amino acids leucine, arginine, glutamic acid and alanine at codons 747, 748, 749, and 750 of SEQ. ID. NO: 511; or c. a mutation in exon 21 that results in an amino acid substitution of arginine for leucine at codon 858 of SEQ. ID. NO: 511 (L858R) or of glutamine for leucine at position 861 of SEQ. ID. NO: 511 (L861Q). a. a mutation in exon 18 that results in a substitution of cysteine for glycine at codon 719 of SEQ. ID. NO: 511 (G719C) or in a substitution of serine for glycine at codon 719 of SEQ. ID. NO: 511 (G719S); or b. an in-frame deletion in exon 19 that results in a deletion of at least amino acids leucine, arginine, glutamic acid and alanine at codons 747, 748, 749, and 750 of SEQ. ID. NO: 511; or c. a mutation in exon 21 that results in an amino acid substitution of arginine for leucine at codon 858 of SEQ. ID. NO: 511 (L858R) or of glutamine for leucine at position 861 of SEQ. ID. NO: 511 (L861Q).
A positioning device that encourages animals to stand in a desired position comprising a base plate with at least one pair of raised portions upstanding from the base plate and one or more valley regions located between the raised portions of each pair of raised portions; wherein the profile of each of the raised portions, is convex, and characterised in that the profile of the one or more of valley regions, is convex.
A base member (108; 1008; 1208) for a stemless humeral shoulder assembly, comprising: - a proximal end (124; 1024) comprising a peripheral member (140; 1040) and a central portion (130; 1030) configured to form at least partly a recess into which a mounting member of an anatomical or reverse shoulder joint interface is received when the mounting member is advanced within the base member (108; 1008; 1208); - a distal end (120; 1020) configured to be embedded in bone; and - a plurality of arms (128; 1028) projecting from the proximal end to the distal end, wherein each of the arms (128; 1028) of the plurality of arms is coupled with the peripheral member (140; 1040) at the proximal end (124; 1024), and the arms of the plurality of arms (128; 1028) are also joined to each other and the central portion (130; 1030) at the distal end (120; 1020), the arms of the plurality of arms being spaced apart in a circumferential direction, and wherein each of the arms of the plurality of arms (128; 1028) comprises a plurality of slots which are disposed between the proximal end (124; 1024) and the distal end (120; 1020) and which project laterally. - a proximal end (124; 1024) comprising a peripheral member (140; 1040) and a central portion (130; 1030) configured to form at least partly a recess into which a mounting member of an anatomical or reverse shoulder joint interface is received when the mounting member is advanced within the base member (108; 1008; 1208); - a distal end (120; 1020) configured to be embedded in bone; and - a plurality of arms (128; 1028) projecting from the proximal end to the distal end, wherein each of the arms (128; 1028) of the plurality of arms is coupled with the peripheral member (140; 1040) at the proximal end (124; 1024), and the arms of the plurality of arms (128; 1028) are also joined to each other and the central portion (130; 1030) at the distal end (120; 1020), the arms of the plurality of arms being spaced apart in a circumferential direction, and wherein each of the arms of the plurality of arms (128; 1028) comprises a plurality of slots which are disposed between the proximal end (124; 1024) and the distal end (120; 1020) and which project laterally.
A system for monitoring a plurality of marine vessels using a satellite network, the system comprising: a plurality of satellite payloads to be carried by respective satellites, each satellite payload comprising a communications interface configured to communicate via the satellite network, a radio frequency transceiver configured to communicate with the plurality of marine vessels, and a controller cooperating with the communications interface and the RF transceiver to obtain automatic identification system data including vessel position and call sign information via the RF transceiver, and communicate the AIS system data via the communications interface; and a terrestrial station configured to receive the AIS system data and determine therefrom a rendezvous between marine vessels which pass within a threshold distance for greater than a threshold time characterized in that the system further comprising at least one source for aerial marine imagery; and the terrestrial station is configured to receive the aerial marine imagery and combine aerial marine imagery and AIS data, wherein the terrestrial station employs a computational operations distributed among a plurality of computing devices which are at different geographical locations and connected by a communications network. a plurality of satellite payloads to be carried by respective satellites, each satellite payload comprising a communications interface configured to communicate via the satellite network, a radio frequency transceiver configured to communicate with the plurality of marine vessels, and a controller cooperating with the communications interface and the RF transceiver to obtain automatic identification system data including vessel position and call sign information via the RF transceiver, and communicate the AIS system data via the communications interface; and a communications interface configured to communicate via the satellite network, a radio frequency transceiver configured to communicate with the plurality of marine vessels, and a controller cooperating with the communications interface and the RF transceiver to obtain automatic identification system data including vessel position and call sign information via the RF transceiver, and communicate the AIS system data via the communications interface; and obtain automatic identification system data including vessel position and call sign information via the RF transceiver, and communicate the AIS system data via the communications interface; and a terrestrial station configured to receive the AIS system data and determine therefrom a rendezvous between marine vessels which pass within a threshold distance for greater than a threshold time characterized in that the system further comprising at least one source for aerial marine imagery; and the terrestrial station is configured to receive the aerial marine imagery and combine aerial marine imagery and AIS data, wherein the terrestrial station employs a computational operations distributed among a plurality of computing devices which are at different geographical locations and connected by a communications network.
An injector having a built-in ignition device comprising: an ignition device comprising: a booster having a resonation structure including an input part center electrode connected to an EM oscillator and a coupling part electrode having a bottom portion into which the input part center electrode is inserted, the input part center electrode being configured to be capacitively-coupled to the coupling part electrode; a ground electrode; and a discharge electrode, the discharge electrode being formed at a distal end of a shaft extending from the bottom center of the coupling part electrode, which are integrally provided to constitute a plasma generator, a potential difference between the ground electrode and the discharge electrode being enhanced by the booster, thereby generating a discharge; a fuel injecting device comprising a valve seat and a nozzle needle having a valve body and configured to move the valve body of the nozzle needle toward or away from the valve seat to control a fuel injection, and wherein the ignition device has a cylindrical member that constitutes an outer circumferential part of the ignition device, and the nozzle needle has a hollow cylindrical shape which is slidably fitted with an outer surface of the cylindrical member of the ignition device. an ignition device comprising: a booster having a resonation structure including an input part center electrode connected to an EM oscillator and a coupling part electrode having a bottom portion into which the input part center electrode is inserted, the input part center electrode being configured to be capacitively-coupled to the coupling part electrode; a ground electrode; and a discharge electrode, the discharge electrode being formed at a distal end of a shaft extending from the bottom center of the coupling part electrode, a booster having a resonation structure including an input part center electrode connected to an EM oscillator and a coupling part electrode having a bottom portion into which the input part center electrode is inserted, the input part center electrode being configured to be capacitively-coupled to the coupling part electrode; a ground electrode; and a discharge electrode, the discharge electrode being formed at a distal end of a shaft extending from the bottom center of the coupling part electrode, which are integrally provided to constitute a plasma generator, a potential difference between the ground electrode and the discharge electrode being enhanced by the booster, thereby generating a discharge; a fuel injecting device comprising a valve seat and a nozzle needle having a valve body and configured to move the valve body of the nozzle needle toward or away from the valve seat to control a fuel injection, and wherein the ignition device has a cylindrical member that constitutes an outer circumferential part of the ignition device, and the nozzle needle has a hollow cylindrical shape which is slidably fitted with an outer surface of the cylindrical member of the ignition device.
Mobile apparatus for programming a sports timing RFID transponder on-site at a sports event, comprising: a supply unit for holding a supply of transponders; a programmer unit including a programming antenna for programming the transponder with an identification information; a conveyor unit for conveying the transponder from the supply unit to a programming position, in which a transponder antenna of the transponder is aligned with the programming antenna, and from the programming position to a dispensing position, in which the transponder can be removed after programming; a processing unit for controlling the programmer unit and the conveyor unit; a robust housing for protecting the programmer unit, the conveyor unit and the processing unit from external force effects; characterized by a reader unit including a reader antenna for reading a transponder in a reading position, wherein said reading position is outside the robust housing in an immediate vicinity of the reader antenna. a supply unit for holding a supply of transponders; a programmer unit including a programming antenna for programming the transponder with an identification information; a conveyor unit for conveying the transponder from the supply unit to a programming position, in which a transponder antenna of the transponder is aligned with the programming antenna, and from the programming position to a dispensing position, in which the transponder can be removed after programming; a processing unit for controlling the programmer unit and the conveyor unit; a robust housing for protecting the programmer unit, the conveyor unit and the processing unit from external force effects; characterized by a reader unit including a reader antenna for reading a transponder in a reading position, wherein said reading position is outside the robust housing in an immediate vicinity of the reader antenna.
Fork tine for preferably automated logistics vehicles, comprising at least a shank, a heel and a blade, wherein fastening elements are arranged on the shank for attachment to a logistics vehicle, whereby the blade and the shank are formed from a top layer and a rear layer to form a cavity, wherein the heel can be inserted over a partial region of the cavity of the shank and the blade, characterized in that the blade and the heel are connected to each other, in particular screwed together, via fastening means, in particular screws, wherein the heel is designed to correspond to the cavity.
A device for sampling discrete physiological events comprising: an optical assembly comprising a catheter including a body having a proximal end and a distal end; an electrode (352; 402; 452) including a tip portion, a base portion (354; 454), and a generally central axis extending from the base portion to the tip portion, a portion of the electrode (352; 402; 452) being connected to the distal end of the catheter; and at least one optical sensor configured to emit or receive an optical signal, at least a part of the optical signal being transverse to the central axis, the optical sensor being operatively connected to one of the electrode (352; 402; 452) and the catheter body; wherein the optical assembly is adapted to sample physiological signals of a subject during a discrete temporal duration by sensing changes in intensity of the optical signal based on displacement associated with the tip portion of the electrode on the contact force exerted by the electrode (352; 402; 452) on the tissue. an optical assembly comprising a catheter including a body having a proximal end and a distal end; an electrode (352; 402; 452) including a tip portion, a base portion (354; 454), and a generally central axis extending from the base portion to the tip portion, a portion of the electrode (352; 402; 452) being connected to the distal end of the catheter; and at least one optical sensor configured to emit or receive an optical signal, at least a part of the optical signal being transverse to the central axis, the optical sensor being operatively connected to one of the electrode (352; 402; 452) and the catheter body; wherein the optical assembly is adapted to sample physiological signals of a subject during a discrete temporal duration by sensing changes in intensity of the optical signal based on displacement associated with the tip portion of the electrode on the contact force exerted by the electrode (352; 402; 452) on the tissue.
A composite pre-bonding treatment method performed when bonding a composite material to a member, the composite pre-bonding treatment method comprising: attaching an absorber adapted to absorb a contaminant to a surface of a prepreg laminate that is a precursor of the composite material; covering the prepreg laminate with a packaging material from above the absorber; vacuuming the packaging material and heating the prepreg laminate at a temperature lower than a curing temperature of a prepreg (1, 25); then removing the packaging material; and peeling off the absorber; characterized in that the composite pre-bonding treatment method further comprises: attaching, to a surface of the prepreg laminate with the absorber peeled off, a release member that does not transfer silicone or fluorine to a resin, and then curing the prepreg laminate to mold the composite material; and peeling off the release member from the composite material before bonding the member. attaching an absorber adapted to absorb a contaminant to a surface of a prepreg laminate that is a precursor of the composite material; covering the prepreg laminate with a packaging material from above the absorber; vacuuming the packaging material and heating the prepreg laminate at a temperature lower than a curing temperature of a prepreg (1, 25); then removing the packaging material; and peeling off the absorber; characterized in that the composite pre-bonding treatment method further comprises: attaching, to a surface of the prepreg laminate with the absorber peeled off, a release member that does not transfer silicone or fluorine to a resin, and then curing the prepreg laminate to mold the composite material; and peeling off the release member from the composite material before bonding the member. attaching, to a surface of the prepreg laminate with the absorber peeled off, a release member that does not transfer silicone or fluorine to a resin, and then curing the prepreg laminate to mold the composite material; and peeling off the release member from the composite material before bonding the member.
A single crystal iron metal-organic framework, the metal organic framework comprising at least one metal-ligand cluster comprising a metal cluster and and one or more ligands having two or more carboxylate groups; wherein the metal cluster has the formula Fe 2 XO, where X is a metal ion selected from the group consisting of Fe, Co, Mn, Zn, Ni, Mg, Cu, or Ca; wherein the single crystal has a size greater than or equal to 10 μm; the metal organic framework comprises cavities having a free diameter of 4 to 40Å; and the metal organic framework comprises pores having a pore volume of from 0.1 cm 3 /g to 4 cm 3 /g.
A component measuring device (10A, 10B) that measures a predetermined component in a body fluid taken into a measuring chip (12, 90), the component measuring device comprising: a chip attachment unit including an insertion hole into which the measuring chip (12, 90) is insertable; a light emitter that applies light to the measuring chip (12, 90) through an introduction port open on a wall surface constituting the insertion hole; a light receiver that receives light from the measuring chip (12, 90) guided through a lead-out port open on the wall surface constituting the insertion hole; a calibration member (36, 100) disposed in the insertion hole slidably along an insertion direction of the measuring chip (12, 90); and biasingmeans for biasing the calibration member (36, 100) toward the insertion port of the insertion hole, wherein the calibration member (36, 100) is held by the biasing means at a position where the calibration member (36, 100) blocks the introduction port and the lead-out port and where light from the light emitter is applied to the calibration member (36, 100) when the measuring chip (12, 90) is not inserted in the insertion hole, and slides to a side opposite to the insertion port along with insertion of the measuring chip (12, 90) into the insertion hole so that light from the light emitter is applied to the measuring chip (12, 90). a chip attachment unit including an insertion hole into which the measuring chip (12, 90) is insertable; a light emitter that applies light to the measuring chip (12, 90) through an introduction port open on a wall surface constituting the insertion hole; a light receiver that receives light from the measuring chip (12, 90) guided through a lead-out port open on the wall surface constituting the insertion hole; a calibration member (36, 100) disposed in the insertion hole slidably along an insertion direction of the measuring chip (12, 90); and biasingmeans for biasing the calibration member (36, 100) toward the insertion port of the insertion hole, wherein the calibration member (36, 100) is held by the biasing means at a position where the calibration member (36, 100) blocks the introduction port and the lead-out port and where light from the light emitter is applied to the calibration member (36, 100) when the measuring chip (12, 90) is not inserted in the insertion hole, and slides to a side opposite to the insertion port along with insertion of the measuring chip (12, 90) into the insertion hole so that light from the light emitter is applied to the measuring chip (12, 90).
A character input device, comprising: an operation unit configured to accept an input operation of a handwritten character and display the handwritten character; a stamp creation unit configured to perform image conversion on the handwritten character to create a stamp; a character recognition unit configured to recognize a reading of the handwritten character; a saving unit configured to save the stamp and the reading of the handwritten character; and an input character management unit, wherein the operation unit includes a candidate display unit, characterized in that: the operation unit further comprises a software keyboard, and the input character management unit is configured to output the stamp as a conversion candidate to the candidate display unit when a character string input with the operation unit using the software keyboard matches the reading of the corresponding handwritten character. an operation unit configured to accept an input operation of a handwritten character and display the handwritten character; a stamp creation unit configured to perform image conversion on the handwritten character to create a stamp; a character recognition unit configured to recognize a reading of the handwritten character; a saving unit configured to save the stamp and the reading of the handwritten character; and an input character management unit, wherein the operation unit includes a candidate display unit, characterized in that: the operation unit further comprises a software keyboard, and the input character management unit is configured to output the stamp as a conversion candidate to the candidate display unit when a character string input with the operation unit using the software keyboard matches the reading of the corresponding handwritten character. the operation unit further comprises a software keyboard, and the input character management unit is configured to output the stamp as a conversion candidate to the candidate display unit when a character string input with the operation unit using the software keyboard matches the reading of the corresponding handwritten character.
A heat pump air conditioning system, comprising a four-way valve, an indoor unit heat exchanger, an indoor throttle device, an outdoor throttle device and an outdoor unit heat exchanger which are connected in series to form a loop, whereby said heat pump air conditioning system further comprises a compressor steam jet system, and said compressor steam jet system comprises a compressor which comprises a first gas inlet, a second gas inlet and a gas outlet, wherein said first gas inlet is connected with said four-way valve through a gas-liquid separator, and said second gas inlet is connected to between said indoor throttle device and said outdoor throttle device by means of the bypass pipe on which an electronic expansion valve is disposed, and said gas outlet is connected with said four-way valve; said compressor steam jet system further comprises a first sensor disposed at the first gas inlet, a second sensor disposed at the second gas inlet, and a third sensor disposed at the gas outlet (113; wherein said indoor throttle device is serially connected to said outdoor throttle device via a liquid reservoir, and said bypass pipe is connected between said indoor throttle device and said liquid reservoir; wherein on said bypass pipe is disposed a coil pipe which is disposed inside said liquid reservoir; when the heat pump air conditioning system is in heating operation under low temperature, the refrigerant flowing out of the indoor unit heat exchanger is divided into two branches; one flow of refrigerant passes the electronic expansion valve which is disposed on said bypass pipe and the coil pipe which is disposed inside the liquid reservoir, and then is absorbed into the second gas inlet of the compressor; the other flow of refrigerant goes directly into the liquid reservoir and passes a cooling coil pipe of the outdoor unit and the auxiliary throttle device then into the outdoor unit heat exchanger.