A compound of formula: wherein A is an amide linker having the following structure: -C(=O)NH- or -NHC(=O)-; Xis N or CH; Yis N or CR 2; Z is N or CR 3; with the proviso that when at least one of X or Z is N, Y cannot be N; R 1 is C 1-5 alkyl, CF 3, C 0-2 alkyleneC 3-5 cycloalkyl or C 0-2 alkyleneC 3-5 cycloalkyl which cycloalkyl is substituted by CH 3; R 2 is H, halo, C 1-2 alkyl, OC 1-2 alkyl, C 1-2 haloalkyl or OC 1-2 haloalkyl; R 3 is H, halo, CH 3, OCH 3, CF 3 or OCF 3; wherein at least one of R 2 and R 3 is H; R 4 and R 5 are each independently H, C 1-6 alkyl, C 1-6 alkylOH, C 1-6 haloalkyl, C 0-2 alkyleneC 3-6 cycloalkyl, C 0-2 alkyleneC 3-6 heterocycloalkyl, C 1-3 alkyleneOC 1-3 alkyl, or R 4 and R 5 together with the carbon atom to which they are attached form a C 3-6 cycloalkyl or C 3-6 heterocycloalkyl; and when A is -NHC(=O)-: R 4 and R 5 may additionally be selected from halo, OC 1-6 haloalkyl, OC 0-2 alkyleneC 3-6 cycloalkyl, OC 0-2 alkyleneC 3-6 heterocycloalkyl, OC 1-6 alkyl and NR 21 R 22; Ar1 is a 6-membered aryl or heteroaryl; Ar2 is a 6-membered aryl or heteroaryl and is attached to Ar1 in the para position relative to the amide; R 10 is H, halo, C 1-3 alkyl, C 1-2 haloalkyl, OC 1-2 alkyl, OC 1-2 haloalkyl or CN; R 11 is H, F, Cl, C 1-2 alkyl, CF 3, OCH 3 or CN; R 12 is attached to Ar2 in the ortho or meta position relative to Ar1 and R 12 is H, halo, C 1-4 alkyl, C 2-4 alkenyl, C 0-2 alkyleneC 3-5 cycloalkyl, OC 1-4 alkyl, OC 0-2 alkyleneC 3-5 cycloalkyl, C 1-4 haloalkyl, OC 1-4 haloalkyl, hydroxy, C 1-4 alkylOH, SO 2 C 1-2 alkyl, C N(C 1-2 alkyl) 2, NHC C 1-3 alkyl or NR 23 R 24; and when A is -NHC(=O)-: R 12 may additionally be selected from CN, OCH 2 CH 2 N(CH 3) 2 and a C 3-6 heterocycloalkyl comprising one nitrogen located at the point of attachment to Ar2, or R 12 together with a nitrogen atom to which it is attached forms an N-oxide (N + -O -); R 13 is H or halo; R 21 is H, C 1-5 alkyl, C C 1-5 alkyl, C OC 1-5 alkyl; R 22 is H or CH 3; R 23 is H or C 1-2 alkyl; and R 24 is H or C 1-2 alkyl; or a salt and/or solvate thereof. A is an amide linker having the following structure: -C(=O)NH- or -NHC(=O)-; Xis N or CH; Yis N or CR 2; Z is N or CR 3; with the proviso that when at least one of X or Z is N, Y cannot be N; R 1 is C 1-5 alkyl, CF 3, C 0-2 alkyleneC 3-5 cycloalkyl or C 0-2 alkyleneC 3-5 cycloalkyl which cycloalkyl is substituted by CH 3; R 2 is H, halo, C 1-2 alkyl, OC 1-2 alkyl, C 1-2 haloalkyl or OC 1-2 haloalkyl; R 3 is H, halo, CH 3, OCH 3, CF 3 or OCF 3; wherein at least one of R 2 and R 3 is H; R 4 and R 5 are each independently H, C 1-6 alkyl, C 1-6 alkylOH, C 1-6 haloalkyl, C 0-2 alkyleneC 3-6 cycloalkyl, C 0-2 alkyleneC 3-6 heterocycloalkyl, C 1-3 alkyleneOC 1-3 alkyl, or R 4 and R 5 together with the carbon atom to which they are attached form a C 3-6 cycloalkyl or C 3-6 heterocycloalkyl; and when A is -NHC(=O)-: R 4 and R 5 may additionally be selected from halo, OC 1-6 haloalkyl, OC 0-2 alkyleneC 3-6 cycloalkyl, OC 0-2 alkyleneC 3-6 heterocycloalkyl, OC 1-6 alkyl and NR 21 R 22; Ar1 is a 6-membered aryl or heteroaryl; Ar2 is a 6-membered aryl or heteroaryl and is attached to Ar1 in the para position relative to the amide; R 10 is H, halo, C 1-3 alkyl, C 1-2 haloalkyl, OC 1-2 alkyl, OC 1-2 haloalkyl or CN; R 11 is H, F, Cl, C 1-2 alkyl, CF 3, OCH 3 or CN; R 12 is attached to Ar2 in the ortho or meta position relative to Ar1 and R 12 is H, halo, C 1-4 alkyl, C 2-4 alkenyl, C 0-2 alkyleneC 3-5 cycloalkyl, OC 1-4 alkyl, OC 0-2 alkyleneC 3-5 cycloalkyl, C 1-4 haloalkyl, OC 1-4 haloalkyl, hydroxy, C 1-4 alkylOH, SO 2 C 1-2 alkyl, C N(C 1-2 alkyl) 2, NHC C 1-3 alkyl or NR 23 R 24; and when A is -NHC(=O)-: R 12 may additionally be selected from CN, OCH 2 CH 2 N(CH 3) 2 and a C 3-6 heterocycloalkyl comprising one nitrogen located at the point of attachment to Ar2, or R 12 together with a nitrogen atom to which it is attached forms an N-oxide (N + -O -); R 13 is H or halo; R 21 is H, C 1-5 alkyl, C C 1-5 alkyl, C OC 1-5 alkyl; R 22 is H or CH 3; R 23 is H or C 1-2 alkyl; and R 24 is H or C 1-2 alkyl;