Hello how may I help you? I want to know how to open up a childproof medicine bottle. Have you read the instructions on the label and/or packaging? No. There might be some instructions there, if not I can offer some advice that may work. I'd like to hear your advice. You could try pushing down on the cap as you twist it. Good advice. Thanks. If that doesn't work, try squeezing the cap while turning. Thanks for all the help. No problem.