title: Palmitoyl pentapeptide-4
Intensive Care Medicine (journal)
Freederm
Active ingredient
Delsym
Aveeno
Excipient
Pediatric Critical Care Medicine
Driclor
Nicotinamide
sentences: Palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006) is a matrikine used in anti-wrinkle cosmetics.
 It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS.
Intensive Care Medicine is a monthly peer reviewed medical journal covering intensive care or critical care and emergency medicine.
 It was established in 1975 as the European Journal of Intensive Care Medicine and obtained its current name in 1977.
 It is the official journal of the European Society of Intensive Care Medicine and the European Society of Paediatric and Neonatal Intensive Care.
 The editor-in-chief is Elie Azoulay (Paris Diderot University).
 It is published by Springer Science+Business Media.
Freederm is a UK brand of acne and skin care medication manufactured by Diomed Developments Limited.
 The products include Nicotinamide as an active ingredient, which is claimed by the company to be "clinically proven to help get rid of inflamed red spots".
An active ingredient (AI) is the ingredient in a pharmaceutical drug that is biologically active.
 The similar terms active pharmaceutical ingredient (API) and bulk active are also used in medicine, and the term active substance may be used for natural products.
 Some medication products may contain more than one active ingredient.
 The traditional word for the API is pharmacon or pharmakon (from Greek: φάρμακον , adapted from pharmacos) which originally denoted a magical substance or drug.
Delsym is a brand of cough medicine owned by Reckitt Benckiser, and manufactured at Unither Manufacturing in Rochester, NY.
 It is different from most brands of cough medicine in that the active ingredient is "time released".
 The time release feature allows the drug to suppress the cough reflex for a longer period of time.
 The active ingredient per teaspoon (5 mL) is dextromethorphan polistirex, equivalent to dextromethorphan HBr 30 mg.
Aveeno is a brand of skin care and hair care products in the United States owned by American consumer goods and pharmaceutical company Johnson & Johnson.
 Aveeno was founded in 1945, and its first product was their Soothing Bath Treatment.
 The active ingredient in all Aveeno products are colloidal oats and/or oat extracts - Avenanthramides, which have been branded as "active naturals".
 Aveeno offers products to treat skin conditions such as eczema, psoriasis, urushiol-induced contact dermatitis, pruritus ani, chickenpox, hives, and sunburn.
An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred to as "bulking agents", "fillers", or "diluents"), or to confer a therapeutic enhancement on the active ingredient in the final dosage form, such as facilitating drug absorption, reducing viscosity, or enhancing solubility.
 Excipients can also be useful in the manufacturing process, to aid in the handling of the active substance concerned such as by facilitating powder flowability or non-stick properties, in addition to aiding "in vitro" stability such as prevention of denaturation or aggregation over the expected shelf life.
 The selection of appropriate excipients also depends upon the route of administration and the dosage form, as well as the active ingredient and other factors.
Pediatric Critical Care Medicine is a peer-reviewed medical journal that covers intensive care treatment of children and newborns.
 It is the official journal of the Society of Critical Care Medicine, the World Federation of Pediatric Intensive and Critical Care Societies, the Pediatric Intensive Care Society, the Latin American Society of Pediatric Intensive Care, and the Japanese Society of Pediatric Intensive and Critical Care.
 It was established in 2000 and is published 9 times a year by Lippincott Williams & Wilkins.
 The editor-in-chief is Patrick M. Kochanek (University of Pittsburgh School of Medicine).
 The journal is published in English with selected abstracts translated into Chinese, French, Italian, Japanese, Portuguese, and Spanish.
Driclor is a strong anti-perspirant manufactured by Stiefel Laboratories (UK) and produced in Sligo, Ireland.
 Driclor is similar to other strong anti-perspirants using 20% aluminium chloride hexahydrate as the active ingredient, however, the water content and roll-on dispenser may cause skin irritancy as water / perspiration can break down the active ingredient to produce hydrochloric acid.
Nicotinamide (NAA), also known as niacinamide, is a vitamin found in food, used as a dietary supplement, and used as a medication.
 As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency).
 While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing.
 As a cream, it is used to treat acne.

Question: Question: Who is the manufacturer of the skin care medicine in UK in which niacinamide vitamin is an active ingredient which is found in food?  

 Your answer will be verified with exact match score. To ensure correct verification, only provide the answer within the <answer> </answer> tags. Do not put any sentences or reasoning process within the <answer> </answer> tags. 

Supporting Information: Paragraph 0 

 Palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006) is a matrikine used in anti-wrinkle cosmetics.
 It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS. 

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Paragraph 1 

 Freederm is a UK brand of acne and skin care medication manufactured by Diomed Developments Limited.
 The products include Nicotinamide as an active ingredient, which is claimed by the company to be "clinically proven to help get rid of inflamed red spots". 

--------------------------------

Paragraph 2 

 An active ingredient (AI) is the ingredient in a pharmaceutical drug that is biologically active.
 The similar terms active pharmaceutical ingredient (API) and bulk active are also used in medicine, and the term active substance may be used for natural products.
 Some medication products may contain more than one active ingredient.
 The traditional word for the API is pharmacon or pharmakon (from Greek: φάρμακον , adapted from pharmacos) which originally denoted a magical substance or drug. 

--------------------------------

Paragraph 3 

 Delsym is a brand of cough medicine owned by Reckitt Benckiser, and manufactured at Unither Manufacturing in Rochester, NY.
 It is different from most brands of cough medicine in that the active ingredient is "time released".
 The time release feature allows the drug to suppress the cough reflex for a longer period of time.
 The active ingredient per teaspoon (5 mL) is dextromethorphan polistirex, equivalent to dextromethorphan HBr 30 mg. 

--------------------------------

Paragraph 4 

 Aveeno is a brand of skin care and hair care products in the United States owned by American consumer goods and pharmaceutical company Johnson & Johnson.
 Aveeno was founded in 1945, and its first product was their Soothing Bath Treatment.
 The active ingredient in all Aveeno products are colloidal oats and/or oat extracts - Avenanthramides, which have been branded as "active naturals".
 Aveeno offers products to treat skin conditions such as eczema, psoriasis, urushiol-induced contact dermatitis, pruritus ani, chickenpox, hives, and sunburn. 

--------------------------------

Paragraph 5 

 Pediatric Critical Care Medicine is a peer-reviewed medical journal that covers intensive care treatment of children and newborns.
 It is the official journal of the Society of Critical Care Medicine, the World Federation of Pediatric Intensive and Critical Care Societies, the Pediatric Intensive Care Society, the Latin American Society of Pediatric Intensive Care, and the Japanese Society of Pediatric Intensive and Critical Care.
 It was established in 2000 and is published 9 times a year by Lippincott Williams & Wilkins.
 The editor-in-chief is Patrick M. Kochanek (University of Pittsburgh School of Medicine).
 The journal is published in English with selected abstracts translated into Chinese, French, Italian, Japanese, Portuguese, and Spanish. 

--------------------------------

Paragraph 6 

 Driclor is a strong anti-perspirant manufactured by Stiefel Laboratories (UK) and produced in Sligo, Ireland.
 Driclor is similar to other strong anti-perspirants using 20% aluminium chloride hexahydrate as the active ingredient, however, the water content and roll-on dispenser may cause skin irritancy as water / perspiration can break down the active ingredient to produce hydrochloric acid. 

--------------------------------

Paragraph 7 

 Nicotinamide (NAA), also known as niacinamide, is a vitamin found in food, used as a dietary supplement, and used as a medication.
 As a supplement, it is used by mouth to prevent and treat pellagra (niacin deficiency).
 While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing.
 As a cream, it is used to treat acne. 

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Answer: Diomed Developments Limited