[{"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As we have previously shown an additional effect of vibrating insoles on improving static balance [3\u20135], it is possible that the combined effect on balance and gait will have a greater impact on falls and mobility than our data would imply. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, gut microbiota analysis in mice treated with hypolipidemic drugs revealed a modification in composition in favor of probiotic-type bacteria from Lactobacillus spp. [49]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is recommended that may be helpful in establishing the direction of the association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further study will be necessary to test if postnatal intervention can effectively promote neurodevelopmental outcomes for healthy infants with below-average white matter development at birth. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, rheumatoid factor and Epstein Barr virus infections have been described to cause falsely elevated C. trachomatis IgM titers 10, 11. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, within this context, it has been proposed that environmental enrichment itself may actually be a mild stressor in mice (Moncek et al 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, a failed quit or reduction attempt is a marker of increased, not decreased, interest in changing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study replicates our prior findings (Hughes et al, 2008) that a) cannabis users trying to change make many, and often rapid, transitions among use as usual, reduction and abstinence states; b) reduction attempts are more common than abstinence attempts; c) quit and reduction attempts are short-lived and few participants achieve long-term abstinence; d) use of alcohol and illicit drugs does not significantly increase with abstinence; and e) few seek treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the use of a cross-sectional design limits ascertainment of direction of association (i.e. it is possible that mindfulness strategies may change after the symptoms of social anxiety disappear), strengthened mindfulness strategies may offer advantages that could plausibly reduce the symptoms of social anxiety. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, tumor metastasis is increased in the lungs of E-selectin\u2013overexpressing mice and reduced in E-selectin knockout mice (18). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This allowed the majority of transplants performed for these patients (189 of 247, 76%) to use a KIR typed donor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the PEEP titration intervals were small (2\u200acm H2O), which was more accurate and might help identify slight changes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since total cortisol concentrations under the intravenous cortisol clamps were comparable in the men and women, and calculated free cortisol levels were actually lower in women, a straightforward hypothesis is that E2 may mediate enhanced (free) cortisol feedback on ACTH secretion in women. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, the study conducted by Jain et. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Short-acting opioids are used for immediate management of breakthrough pain and even NP episodes (in the context of an anticonvulsant and/or TCA regimen) (Eisenberg, McNicol, & Carr, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The underlying question in most prayer studies is \u2018does prayer influence health\u2019. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The existence and phenotype of MICs was first reported in the peripheral blood of primary human luminal breast cancer using a xenograft assay 30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the B/H24 sublineage, the introduction of the fluoroquinolone resistance by mutations in gyrA and parC (B2/H24R) and the introduction of blaCTX-M-15 (B3/H24Rx) were also estimated to have occurred around 1987 concurrently with the widespread clinical introduction of extended-spectrum cephalosporins and fluoroquinolones (Fig. 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given this, further studies on reduction as a treatment goal are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several constructive recommendations for the private and public sectors can be drawn from this investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, different mechanisms of liver fibrogenesis and carcinogenesis might operate in HBV- and HCV-related chronic inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we did not distinguish between short and long daytime nap duration, which remains to be elucidated in further studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possibly, these patients had been severely restricted in their quality of life before the operation as a result of the discomfort of the spondylitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the cross-sectional design limits our study, and these limits are especially noteworthy in prayer research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Especially in the setting of sepsis it is the main reason for multiorgan failure and increased mortality 19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it is difficult to make a clear statement about possible different effects as a consequence of macronutrient restriction. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Imaging studies have shown that approximately 100% of patients have abnormal shape in their bilateral or (and) unilateral adrenal gland, but these have different anatomic abnormality (adenomas, hyperplasia, tubercle). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An alteration in the regulation of cytokines may negatively affect the mechanism of host defense and render the host vulnerable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data showed that girls aged 13 and 14 years of age had particularly higher risk of having more severe atopic dermatitis and this may be due to the changes in hormones associated with menarche. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hydration with bicarbonate for prophylaxis of CIN has been investigated in more than 20 clinical trials with heterogeneous but mostly positive effects 16,27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depending on the degree to which these elements congregate, a wide range of phenotypes arises. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this 3-year, cluster-randomized controlled, longitudinal efficacy study have implications for practice, policy, and research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings may differ from this prior study because periods of abstinence in our study were very short. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main message of these last studies was that transsexuals showed no evidence of psychopathology according to the MMPI-2 profile, and transsexualism can exist independent of other psychopathology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While amblyopia has a prevalence during childhood of approximately 2%,31\u201333 the prevalence of risk factors for amblyopia are much higher at 15 to 20%,34\u201337 leading to the likelihood of over-referral. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The impact on obesity status in adult carriers appears less pronounced, but there is nevertheless an appreciable increase in BMI (corresponding to 15\u201319 kg in weight for subjects 160\u2013180 cm in height). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From this study, the proportion of EHs involved higher difference than the PHs in Family heredity ,however, we defined any history of familial hypertension as Family heredity ascribed to the posterior awareness of primary aldosteronism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The shorter scan time has potential to improve spatial resolution and reduce image artifacts caused by increased motion instability during the long scan time [13, 15]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of the 127 international ST410 isolates in our study were collected from humans (119/127); however, eight isolates were from nonhuman sources. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Animal and human models underline that tubular epithelial cells are susceptible to apoptosis and injury may contribute to organ failure [19, 20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, people with a family history of CHD and GT/TT genotype of rs1130214 or AG/GG genotype of rs3803300 were easily attacked by CHD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, our study design was cross-sectional, the associations causality need cohort studies with follow-up data to strengthen the understanding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obviously, diet is an important factor determining the composition of the gut microbiota. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it would seem that object knowledge is an experientially acquired faculty that should be tested with items that the subject has used and encountered frequently, not with items that may predominantly elicit encyclopaedic, and therefore verbal rather than experiential, associations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This biker position was initially developed as an equivalent to the prone position adapted to the particular geometry of the D.SPECT camera, for which image recording in the prone position may not be proposed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are consistent with previous work by Lisco et al reporting increased compartmentalization of many proinflammatory cytokines in the setting of HIV-1 infection18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the past, stress exposures of various durations have been associated with a decrease in synapses and neuropil in fronto-limbic cortical areas (Andersen & Teicher, 2004; Gos et al, 2008; Huot, Plotsky, Lenox, & McNamara, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, a potential disadvantage was the relatively small sample size in the present study, an epidemiological investigation with larger sample size is needed to verify the results in the future. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential for selection bias is acknowledged. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strengths and limitations Regarding strengths, the study was a thoroughly executed, randomized controlled trial following the CONSORT statement. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar ethnic differences in rapid BMI gain trajectories have also been reported between African-American and white children in the U.S12. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparative data are needed to determine if the acute sensitivity of growth to immune function and other energetic stressors is unique to humans or is more widely characteristic of large-brained primates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have identified that a loss of Dicer contributes to tumorigenesis progression via DNA damage69,70. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observations are consistent with our prior findings that local factors such as sphingolipid-related enzymes are a key mediator of danger signaling in podocytes irrespectively of the level of circulating factors (43). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pre-study sample size projection was based upon estimates that 70% of searches would KIR genotype 5 or more donors and 30% would type 3 donors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, CMRA offers a relatively safe tool for the evaluation of the cardiac venous anatomy. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The SNP rs3742330 located in the 3\u2032-UTR of DICER1 has been reported to be the target site of two miRNAs, miR-3622a-5p and miR-5582-5p61,62. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that these exposures occur at the periods when the epigenetic signature is more plastic, they might also lead to aberrant DNA methylation changes which will be inherited during cell divisions and be detectable years later. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "People are also exposed to food environments as they go about their daily activities (e.g. during travel and at work), although we were unable to measure these exposures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most EV-D68 cases were identified from hospitals, which may have overestimated the severity of infection, with only severe cases being hospitalised, and also biased findings towards child cases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other factors that compromise neuromuscular transmission in previously recognized congenital myasthenic syndromes, e.g., decrease of evoked quantal release, diminished expression of AChE or AChR, a kinetic defect in AChR, or alteration of EP geometry, were excluded by the EP studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Instead, environmental exposures at the periods of developmental plasticity are likely to be the cause of the dramatic decrease in age at menarche. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have explored the deregulation of DICER1, which is required for miRNA processing, as part of CRC etiology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Forty genes were associated (p<0.05) with risk of breast cancer in the Mayo Clinic population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, Romero et al. [27] and Yoon et al. [11] reported that IL-6 concentration in amniotic fluid is a more sensitive measure for predicting intrauterine inflammation than gram staining, the glucose concentration, or the white blood cell count of amniotic fluid. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, while HLM analyses were used to study inter-individual and intra-individual differences, other areas of interest include the examination of higher, house-level predictors (i.e., social climate, ethnic composition of a house) on these individual-level outcomes remains unexplored. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One potential source identified was straw board in walls and ceilings disturbed by the renovation work. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, surgery is usually recommended for patients with localized lung disease who can withstand lung resection after an initial period on antimicrobials to reduce the microbial burden (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When correlating echogenicity with tissue pathology in rats, Tabel et al20 demonstrated hyperechoic tissue only within older infarcts where thick collagen fibers were present. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The inhibition of the enzyme MTHFR is responsible for the increas in homocystein level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SNPs in the 3\u2032-UTR have been reported to contribute to the regulation of transcript stabilization48. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may have resulted in a dilution of the effects of food environment on cardiovascular risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main aim of this trial was to investigate whether the effi - cacy\u2014evaluated by improvement in patient-reported outcome\u2014was better in patients who underwent THA with PA rather than THA with LA, 12 months postoperatively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We demonstrate significant associations between seminal plasma IFN-\u03b3, IL-17, and IL-5 and seminal plasma HIV-1 RNA levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ability of TNF to inhibit ABCA1 expression and function in podocytes (Figure 4) may be cell-type specific, as in macrophages TNF expression positively correlates with ABCA1 expression and ABCA1-mediated cholesterol efflux (27). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Li et al summarize multiple populations of others researchers to analyze the association of the common polymorphism C667T in methylenetetrahydrofolate reductase gene with CHD risk, the results indicate that methylenetetrahydrofolate reductase C667T polymorphism is relevant to CHD with obvious heterogeneity in a meta-analysis[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BMD and fracture risk are determined both by environmental and genetic factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of the large number of genes and SNPs assessed in this relatively small sample, we had limited statistical power to detect significant associations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Earlier, in a study conducted among 638 elderly Spanish individuals with a high risk for cardiovascular diseases, eating competence was associated with a lower risk of IFG [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The significant decrease in the symptom score and in the level of specific IgE against Par j 2 also pointed to good clinical efficacy of the vaccine. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have demonstrated that the effects of specific forms of immune activity on growth are consistent with expected energy use and transpire across a wide range of timeframes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We annotated only the most significant SNPs that met a stringent P value threshold for significance (typically 5 \u00d7 10\u22128) to adjust for multiple testing problems in a single-SNP approach. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be due to the mice experiencing a mild \u201cenrichment effect\u201d as consequence of out maternal separation protocol and subsequent changes in maternal care, or, as adults, due to behavioral testing in the Open Field Object Recognition test. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore longer sleep duration could be a subtle marker of the disease, rather than as a cause of stroke. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent experimental evidence suggests that local TNF causes inflammasome activation (51) and is associated with altered cholesterol homeostasis (52). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several previous studies have described the psychological testing of transsexuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, both of the two GWASs were performed in LC patients developed from chronic hepatitis C. Till present, no GWAS has been conducted to systematically identify genetic variants associated with HBV-related LC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contaminated straw board represents a potential source of Q fever and should be considered in future outbreak investigations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pharmacological therapies should be supplemented by multidisciplinary approaches such as physical therapy and psychological interventions. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "VitROShield is the combination of hyaluronan, gentamicin and the antioxidant lipoate in the culture system and protects from pH induced stress, free oxygen radicals, infections and cryo damage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential circulating factors in FSGS that may affect glomerular TNF expression remain to be identified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Males generally had significantly larger dental arch measurements than females. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recruited participants in this study were patients attending OHC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Chong et al, 2002; Lee., 2003) In the present sutdy, only 16% of the health care professionals were performing BSE. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To avoid the risk of comparing surgeon skills or surgeon preference rather than the surgical procedure, 3 equally experienced surgeons participated in each team. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Paracetamol (also known as acetaminophen) was the most commonly used analgesic by patients with dental pain in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taxonomic interference and the architecture of lexicosemantic mapping In the chronometric task of the NOMINA, the subjects had to match a word to one of two objects of the same or different taxonomic categories. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the number of SSc patients in our study was much higher than in original report [13], in one particular situation it may be considered as \u201csuboptimal:\u201d our study may not be powerful enough to detect possible \u201ctrue association\u201d in case that it would be much weaker than observed in initial German study [13]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, measuring the NLR has other advantages, such as that the test sample may be simply obtained and the NLR may be easily measured using conventional facilities, without the need of additional instruments or reagents. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A higher density of fruit and vegetable vendors was associated with a decrease in fasting glucose and blood pressure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, we only have finite clinical data about renal artery stenosis and renin adenoma, as we know they still account for the suggestible reason of ARR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, this study provides evidence that abnormal scores on the LOS may be more predominant than abnormalities on the SOT in chronic mild to moderate TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In some cases, as in those presented in this article, peak atrophy sites are initially located predominantly in the left anterior temporal lobe and give rise to a clinical syndrome that fulfils the core PPA criteria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This increased percentage in tooth size discrepancy in our sample led to a significant increase in the means of Bolton\u2019s ratio when compared to the normal ratio of the Bolton study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, utilizing complementary cross-sectional and longitudinal surveys reveals that this disease appears to adversely affect the condition and perhaps the survival of infected individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it is very important to study the genetic mechanism of CHD at the molecular level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Positive individuals showed a significantly greater reduction in BC between primary sessions than non-infected voles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The argument has also been advanced that object knowledge failures in this group of patients can only be detected when tested with unfamiliar items. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found no superior effi cacy of using the PA compared with LA, as evaluated from patient-reported physical function, pain, physical activity, and quality of life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The end stage manifestation of atherosclerotic disease \u2013 the presence of carotid plaque\u2013 was found in only two of our older HGPS subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, a double-blind placebo-controlled study should be performed in order to assess clearly the clinical efficacy of these accelerated schedules. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should also be stated that the incidence and distribution of bone metastases would change significantly in centres where more patients with kidney, lung and prostate cancer are treated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was assumed that the cytokines and chemokines secreted from the partial inflammatory lesion in the choriodecidua generated during the early stage of intrauterine inflammation may enter the blood of a pregnant woman and cause changes in the counts of leukocyte subtypes [17], [18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In support of our observations, Pedraza et al  found that the CLU rs11136000 T allele associated with decreased risk of AD was associated with higher scores on the Logical Memory delayed paragraph recall subtest from the Wechsler Memory Scale-Revised in white study participants, while Carasquillo et al  reported that the CLU rs11136000 C risk allele was associated with lower scores at baseline on the same test [Carrasquillo et al  2015; Pedraza et al  2014]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Social support and social interventions are factors potentially related to QoL, and confirming these associations in future research would have major public health implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of the two prophylactic regimes is superior to prophylaxis with theophylline only. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, the postoperative infection rates of laparoscopic hysterectomy in the 1\u20132-week, 4\u20136-week, and 6-week groups were 60.0%, 9.1%, and 0%, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overexpression of ABCA1 in Nfatc1nuc mice (TT) was sufficient to prevent this CKD-like phenotype. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For short sleep duration, the lack of association with stroke risk is possibly due to the modified effects of factors including daytime naps, sleep disorders, and sleep quality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RTX is now considered an effective treatment of refractory head and neck manifestations with remission rates reaching more than 80% in small cohort studies34. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An alternative conceptualization, based on the classic lesion-induced dissociations between aphasia and object agnosia, invokes two separate, but interactive, routes of processing in the temporal lobes\u2014a strongly left-dominant temporosylvian network for verbal concepts and a presumably more bilateral or right-sided inferotemporal/fusiform network for pictorially triggered object concepts (Damasio, 1985; Mesulam, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study confirms that a low oxygen concentration may signifi cantly improve the developmental potential of cleavage stage embryos, thus resulting in a positive effect on subsequent blastocyst cultivation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CLU rs11136000 C risk allele, was related to a more rapid trajectory of cognitive decline as measured by the 3MS global test of cognition in 1,831 subjects initially free of dementia in the Cardiovascular Health Study (mean age at baseline 71.7 years). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While we showed the ability of the model in accounting for several behavioral patterns in humans/animals, whether or not people use such algorithm requires further direct experiments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, this may have been a marker for patients who were generally more adherent to treatment and more willing to accept treatment intensification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, the study by Winther et al (2015) could not detect any difference in hip muscle strength at 3 months between the PA patients and the LA patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the effect sizes were in the same range for all three cohorts evaluated in the present study, indicating that such a possible overestimation of the effect sizes for MrOS Sweden is marginal. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite these limitations, this study offers new perspectives in the field of prayer and pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the assessment of word and object knowledge was not done with identically modelled tasks, the patterns of impairment and relative sparing in Figs 5\u20137 suggest that the left anterior temporal lobe is more critical for the integrity of verbal than non-verbal associations of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Staff may not wish to mention these events and their recall may not be accurate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, caution must be observed in the choice of laparoscopic surgery because pneumoperitoneum may influence the pulmonary capacity or reserve for patients with severe pulmonary disease. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, post-orthodontic stability depends greatly on the maintenance of lower inter-canine distance during treatment, without significant expansion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that HCA has been shown to be associated with increased blood levels of inflammatory markers, we hypothesized that the NLR should be affected during the inflammatory processes of HCA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the atrophy progresses, all patterns converge toward combined aphasic and agnosic impairments, collectively attributed to a core semantic deficit (Gainotti, 2012). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The photoscreener was quick, reasonably easy to operate, and fully portable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to these differences, alternative measures of deglutition are necessary for defining swallowing parameters in this animal model. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies should explore the cost-effectiveness of regular screening and treatment of HCV for this vulnerable population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To overcome this problem, we used the reported data from the largest published study conducted to date on prostate cancer progression 5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of C. trachomatis is increasing in young women despite increased screening and awareness, highlighting the importance of accurate and sensitive diagnosis 7. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is likely that as the algorithms used to prescribe amounts and types of reading instruction and technology to support teachers\u2019 implementation improve, so too will students\u2019 reading outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data show a complex pattern of layer, sex and experience specific alteration in cortical thickness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We confirm a marked increase in the risk of severe childhood obesity in carriers of the 220 kb deletion, which accounts for a total of 0.5% of the combined cases from our study and the original report. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, generalized UniFrac distances demonstrated a distinct clustering between the walnut and the control groups as well as between the different diet types, demonstrating that beta-diversity was altered by walnut consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A feral cat had given birth in an adjacent building 1\u20132 years previously. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The variance explained in BMD was similar for men and women supporting the idea that men and women share, to a large extent, genetic mechanisms that determine BMD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In ECMO-treated patients receiving unfractionated heparin, laboratory monitoring should target for 1.5- to 1.8-fold prolongation of the baseline APTT. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are broadly similar to previous Australian research,11 and compared favorably to findings from the US truck drivers,5 who eat less fruit and vegetables and more unhealthy foods than Australian drivers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The very low rate of metastases in this study could be attributed to the supposition that cancer patients, especially those with residual macroscopic disease (R2) die of causes related or unrelated to their illness before developing loco-regional or distant metastases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using Dutch Caucasian osteoarthritis cases in their discovery sample, with strong signals then genotyped in cohorts from Europe and North America, Kerkhof and colleagues identified a locus on chromosome 7q22 that was associated with knee and/ or hand osteoarthritis at SNP rs3815148 [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, while the subcutaneous fat fraction increased proportionally with increasing BMI, the skeletal muscle fraction did not change proportionally across all BMI strata (Fig 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our experience, TEE has provided valuable capabilities in the evaluation of patients with intracardiac masses. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term longitudinal analyses will clarify these findings and illuminate the lasting impact of immune-related tradeoffs on body size. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We are strongly convinced of the benefits of laparoscopy in the case of gastric cancer; therefore, it is our method of choice in all cases, so we are not able to provide open surgery cases to compare with our results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "How the psychopathology profile is assessed warrants further discussion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clearly, future studies will need to investigate corticosterone levels under various rearing conditions, but within the same animal model, in order to more clearly establish the boundaries between rearing conditions currently designated as enrichment vs. stress. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest many Australian truck drivers have poor physical activity behaviors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the vibrating insoles, 6.3% and 5.8% reductions were observed in stance time variability for the recurrent faller and non-faller groups, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, some authors have recently reported that initiating the hormonal treatment in untreated patients seemed to have a positive effect for reducing stress levels45 and more generally psychopathology46. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By definition, individuals did and did not undergo hormonal therapy were not in the same phase of the sex reassignment procedure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "\u201cMoving the needle\u201d on such challenging behaviors in underserved populations may require tailored and even individualized approaches to dietary change and weight loss to address physiological factors shaping energy balance behaviors alongside structural change to promote improved PA and f/v consumption.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Instrumentation of the fused sector of the spinal column is intended to bring about a lasting straightening of the deformed spinal segments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results were similar to a previous study by Sundell et al, [20], who assessed BMQ-General among the general population in relation to the use of Over-The-Counter medicines. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oxygen at a concentration of 20% has been shown to give rise to the epigenetics modifications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Kovacic et al. [8] reported low oxygen is recommended for poor responder patients with more optimal embryos to select (62.5%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It means that we will expand the proportion of these in future researches. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, despite controlling for a range of covariates in our analysis, there is a risk in residual and unmeasured confounding and measurement error which may bias our analyses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This survey has some limitations, namely: the intrinsic limits of the study design itself, the poor data obtained in the study population with respect to specific conditions and behaviors (i.e., obesity, alcohol consumption, or smoking habits) that are considered variables involved in the decrease of the immunogenicity of HBV vaccine over time,25 and the fact that not all the HCSs were compliant with the procedures of the study protocol and were consequently discharged. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This discrepancy must be evaluated in further trials. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gabapentin has been in use for NP at St. Jude since 1997. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, for hysterectomy within 1\u20132 weeks after conization, the postoperative infection rate associated with laparoscopic hysterectomy (60.0%) was higher than that associated with abdominal hysterectomy (33.3%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pain caused by mechanical trauma and stretching of nerves during surgery may persist for weeks to months, independently of ongoing tissue injury or inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, according to recent systemic reviews and a meta-analysis conducted by Lamont's group, maternal serum CRP may not be considered a reliable indicator of either clinical or histologic chorioamnionitis due to the presence of differences among studies [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a considerable prevalence of hypertension among Xinjiang, northwest China; with low awareness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moldy hay from this barn, cultured using cell growth medium, grew C. burnetii. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, while we did not observe a stress induced improvements in learning/memory performance in either STR or LMC mice, neither did we see a decrease in cognitive performance, as reported by many previous studies utilizing longer duration stress protocols (Anisman et al, 1998; Levine, 2002; de Kloet et al, 2005; Meaney, Diorio, Francis, Widdowson, LaPlante, Caldji, Sharma, Seckl, & Plotsky, 1996; Liu et al 2000). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mariano et al. [18] observed proapoptotic effect in tubular cells incubated with plasma from septic patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the white matter regions we identified still have important implications for respective functions and are consistent with literature studying relationships between brain structure and neurodevelopment in healthy children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LCGMM is capable of modelling non-linear growth curves, estimating individual trajectories and identifying distinctive subgroups in the population37. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, regardless of the deficiency, both the old and parkinsonian rats self-selected smaller bolus sizes compared with the young adult rats. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was surprising that the Chennai-specific model did not perform better than the full conceptual model that included some variables with inverse associations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether the genes from the TSPs belong to specific pathways or have specific biologic functions is an interesting question. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Framed in the transactional theory of stress and coping, re-appraisal of the pain situation seems to be an important factor for understanding the relationship between prayer and pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The weak performance of the conceptual and composite variable could be due to the inclusion of several variables with inverse associations with active commuting (e.g., street connectivity, land-use mix\u2014access), suggesting that a different combination of environmental variables may be optimal in some LMIC contexts. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of tooth size discrepancy was 43.6% for anterior ratio and 24.8% for overall ratio. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of low oxygen will not affect the clinical outcome in the fresh cleavage-transfer cycles, but it will result in more favorable clinical outcomes in the subsequent warming blastocyst-transfer cycles, with statistically significantly higher CPR and IR compared with atmospheric oxygen, indicating that the detrimental effect of atmospheric oxygen on human pre-compaction embryos are cumulative and would manifest at the later stages of preimplantation development. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Looking into our results, we noted that the rate of severe complications was 13.2%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent large-scale meta-analysis identified 63 autosomal SNPs associated with BMD and 16 BMD-associated SNPs were also associated with fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, our observation of an apparent high rate of false positives is likely to reflect insufficient control of the FDR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, some newer trials facilitate the administration of high-dose statin directly before the examination with positive results 36. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The dynamic measurements of pulmonary function, MVV (Figure 2; p=0.025) and VEmax (Figure 3; p=0.02), were significantly higher in oxandrolone-treated subjects compared to untreated subjects at 6 months post burn. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The method of measuring the cytokine concentration in amniotic fluid appears very promising, having achieved particularly high sensitivity and specificity. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, childhood obesity disrupts the hormonal milieu leading to an increase in adipocyte secreted leptin, or in adrenal secreted androgens, all of which impact on menarcheal onset [34]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the case of gastric surgery, it is almost 80%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One straightforward approach might be to apply a locus-specific multiple-testing correction, according to GSV complexity, to reflect the number of independent tests made at a locus, in a manner similar to that used to correct for multiple tests of SNPs in linkage disequilibrium [40]. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Grade 4 elevations of AST and ALT occurred in 1% and 2% of cycles, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whatever the bases for existing discrepancies, earlier clinical assessments suggested increased feedback sensitivity in women (10), no gender difference (8), and decreased feedback sensitivity in women (23, 40). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The product has also been exported around the world. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, numerous studies confirm the central role of abdominal obesity as the main metabolic syndrome component associated with early organ damage in the patients with metabolic syndrome [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Current study results show a shift within the composition of microbial communities in the human gut under nut consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cultural influences and theoretical viewpoints may impact treatment and gender reassignment in France and future studies should consider this parameter to clearly understand/interpret the impact that the psychological profile of transsexuals has on therapeutic strategies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More data on endogenous sex hormones need to be collected from further large prospective studies after a long follow-up period, but the evidence that endogenous oestradiol concentration is related to breast cancer risk in post-menopausal women is becoming strong.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BVAS score also improved after treatment, however, persistent ENT symptoms were scored as disease activity and it is worth considering the difficulty in clinically distinguishing between active disease and tissue damage and therefore BVAS may in fact over emphasize extent of disease activity after RTX. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "no discussion section", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In six of the PPA subjects, however, the magnitude of this effect was beyond the range seen in the control group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further supporting the role for local TNF expression, it was shown that TNF inhibitors demonstrate efficacy in a subset of patients with FSGS enrolled in the FONT Study (14, 42) in the absence of evidence of elevated serum TNF levels in these patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In case of contraindications for anticoagulation, physical measures should be used (e.g., medical compression stockings). ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are some limitations to consider when translating the current videofluorographic findings in the rat to standard videofluorography in humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduction of uncertainty is a variable that changes monotonically with the discount factor: the smaller the \u03b3, the less dependence of the value of each strategy on uncertain cached values on the leaves and therefore, the more reduction of uncertainty by deepening the tree. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The aim of this study was to focus on the under-investigated aspect of personal religious factors, especially prayer, in the pain management of West-European CP patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A genetic risk score that included 10 variants detected in GWAS of AD but excluded APOE \u03b5 4 was also marginally associated with a compound test score for memory in 5,171 non-demented persons from the population-based Rotterdam Study (mean age 66.2 years) [Verhaaren et al  2013], and a genetic risk score constructed from 22 AD-associated loci was associated with significantly faster decline in a composite memory score in 7,172 non-Hispanic white (mean age 63.0 years) but not in 1,081 non-Hispanic black participants (mean age 61.6 years) in the nationally representative Health and Retirement Study [Marden et al  2016]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other limitations include: 1) possible extra-adrenal effects of KTCZ; however, exogenous cortisol normalized ACTH concentrations otherwise stimulated by KTCZ administration; 2) possible diurnal or seasonal effects (26, 40); 3) unknown effects of CBG per se on feedback by cortisol; and 4) uncertainty regarding long-term gonadal-steroid effects on HPA axis regulation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Quality of life itself is not a pre-determined characteristic \u2013 it can be modified if public health specialists target appropriate interventions at specific groups of people. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher rates of visual impairment have been reported among persons aged 12 and above among Hispanics and Blacks compared to Caucasians 24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To date, no human feeding trials are available to discuss the effect of walnut consumption on the Firmicutes/Bacteroidetes ratio. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The temporal relationship between exposure and outcome cannot be ascertained in a cross-sectional analysis; however, undiagnosed cardiovascular risk factors are unlikely to impact on the physical food environment or eating patterns. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinically significant central nervous system or respiratory depression attributed to epidural analgesia can be avoided by slow titration, careful monitoring of sedation levels and respiratory status, and reduction of the opioid dose when sedation increases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our morphological findings, for both STR and LMC mice, most closely resemble observations by Gibb and Kolb (Gibb & Kolb, 2005) of significantly increased overall, parietal cortical thickness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With 26 weeks of randomized continuation treatment, the duration of the phase referring to the confirmatory hypothesis test is consistent with Kupfer\u2019s (1991) widely accepted model of the long-term course of depression as well as with findings from trials investigating the optimal length of continuation therapy (Prien and Kupfer, 1986; Reimherr, Amsterdam, Quitkin, Rosenbaum, Fava, Zajecka, Beasley, Michelson, Roback and Sundell, 1998), so that the efficacy of WS\u00ae 5570 in preventing relapse can be validly assessed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The resulting data strongly confirm the previously reported association between endogenous oestradiol and breast cancer risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the present study adds to other evidence from LMICs [35,37,48] that car ownership appears to negate any effect of walkable neighborhood design on active commuting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the study of AKT1 single polymorphism, rs2494732 wasn\u2019t detected the association with CHD, either genotypes or alleles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found a higher density of fruit and vegetable vendors was associated with a decrease in blood pressure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More human intervention trials investigating different servings of nuts over a longer time period might be useful to further evaluate the prebiotic properties of walnut consumption.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first report involving the impact of oxygen concentration on human pre-compaction embryos using a prospective randomized sibling-oocyte study model in a Chinese population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More marked hypovitaminosis D leads to the accumulation of osteoid and the mineralisation defect characteristic of osteomalacia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Careful deep rasping of the greater trochanter is the key to avoiding cortical-bone damage. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, we found that higher density of highly processed and take-away food vendors within 400\u202fm buffer, but not 1600\u202fm buffer or distance to nearest vendor, was associated with increased BMI and waist circumference. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings in this study were consistent with those in a previous study that reported fatalist attitudes are prevalent and fear of cancer is frequent among those who live in lower socioeconomic conditions (Byrne, 2009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have identified four distinct BMIz trajectories in the first 2 years of life in a multi-ethnic cohort of Asian children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, it would be interesting to determine whether circulating autoantibodies including anti-CD40 (46) or cytokine receptor\u2013like factor-1 (CRLF-1) (47), which are linked to proteinuria in FSGS, may cause TNF-mediated podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using data from the KYRBWS-VI, this study was cross-sectional in design; thus, it examined the interrelationship between stress and atopic dermatitis rather than issues of causality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide evidence that both duration (reflected by stable high BMIz and stable low BMIz trajectories) and age of onset (reflected by rapid BMIz gain trajectory) of excess adiposity may be important factors in predicting subsequent cardio-metabolic risk. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MtF individuals appeared more affected than FtMs on three other scales: Hypochondriasis, Depression and Hysteria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of tooth size discrepancy in this study was 20% in males and 28% in females for overall ratio and 40% in males and 46% in females for anterior ratio. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, many other postnatal factors, such as parenting style and exposure to adverse environment, which were not assessed in our study, may also confound the findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That method is simple and straightforward to implement, while LCGMM is relatively computer-intensive. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here, we employed the global dynamic compliance and regional EIT to guide intraoperative PEEP selection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a study, Hong et al. reported an association of ACE gene I/D polymorphism with primary knee osteoarthritis in a homogeneous Korean population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, angiogenin could be involved in the host response to inflammatory processes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reported inhibition studies using rabbit anti-sera have demonstrated that polymerization did not produce new antigenic determinants [16,22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The more granular neuropsychological assessment of progesterone's purported neuroprotective properties did not reveal a significant effect, and the findings were concordant with the GOSE primary outcome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, when hysterectomy is performed 4 weeks after conization, laparoscopy is preferred, with lower rates of postoperative infection and complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine drainage was also associated with no benefit in the postoperative period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither CAC nor PIC, however, are currently well defined. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The explanation might be the following: as uterine arteries and ligaments close to the cervix were mainly managed by electrosurgery in laparoscopic hysterectomy, inflammatory hyperemia around the cervix would reach its peak approximately 1\u20132 weeks after conization, resulting in more coagulation and hemostasis from hysterectomy using bipolar electrosurgery during this period, with thermal radiation burns affecting the function of surrounding tissues [22\u201325]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The negative predictive value of C. trachomatis MIF was high (98%), which correlates with another serological study that showed a high negative predictive value for C. trachomatis enzyme immunoassay 6. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the participants who were \u226540 years old had more information about breast cancer, the benefit perception of BSE, health motivation and self-efficacy perception were lower in this age group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants in Oxford House share their background, discuss drug histories, talk about personal and group goals, eat together, engage in chores, and attend 12-step meetings and go on other outings with one another (Olson et al, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, when hysterectomy was performed 4\u20136 weeks after conization, the postoperative infection rates, severity of infection, grade and days of using antibiotics, and inflammatory cell infiltration decreased significantly, with no postoperative bleeding and fewer complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Once a dose has been reduced because of toxicity, dose escalation in the subsequent cycles is not recommended. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies are needed to investigate the role of TNF- or NFAT-mediated dysregulation of cholesterol homeostasis in the context of nonglomerular diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, reduction was a common goal in our study and predicted a greater probability of a quit attempt and a decrease in problems or dependence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, we describe for the first time to our knowledge the opposing roles of free (proapoptotic) and esterified cholesterol (antiapoptotic) as key mediators of TNF-induced podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also demonstrates that it is important to test for both IgG and IgM antibodies to optimize the likelihood of detecting a serologic response.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our unacceptable 6.5% rate of fractures of the greater trochanter during operation was mainly due to the early experience of both surgeons with the technically demanding stem implantation technique. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "al targeted customers visiting pharmacies [11]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the last decades, many researchers aimed to identify causal genetic variants by means of candidate gene analyses, Genetic research is done to identify underlying causative genes and pathways, and thereby understand more about the biology of the disease with potential implications for development of novel treatments, and to be able to predict risk of disease by genotyping the identified risk alleles [23]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, patients with and without CKD both had higher BP control in the TI group vs. UC group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, we showed that CD133+CD44+CD54+ subpopulation of CTCs has a prognostic value in CRC with liver metastasis, and has a significant effect on the survival of CRC patients who did not undergo surgical treatment for metastasis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A beneficial effect of daytime napping for stroke and its subtypes was shown in our research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We were unable to establish the positive predictive value of our screening efforts because of non-compliant follow-through for a professional evaluation among those identified for referral and the design of the study was not intended to provide formal ophthalmologic examination to all participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endothelial NO synthase gene genetic variant is also detected to contribute to the risk of sporadic CHD[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We did not find an association between breastfeeding and the BMIz trajectories, consistent with earlier studies by Pryor et al14, Giles et al17 and Garden et al43. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CR1 (rs3818361) [Hollingworth et al  2011] was associated with more rapid decline on the DSST in the same study, while PICALM (rs3851179 and rs541458 [Harold et al  2009] was associated with an earlier age at midpoint of decline of the 3MS [Sweet et al  2012]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is lower than US population screening rates (12.7%).8 Given the high prevalence of HCV among people with SMI,2,9 this finding represents a significant public health concern. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A hyperinflammatory response arises in some patients, resulting in a cytokine storm and dramatic changes in coagulation tests, including elevated D-dimers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have expanded upon previous studies examining the relationship between seminal plasma HIV-1 RNA level and seminal plasma cytokines by controlling for blood plasma HIV-1 RNA level in our model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further study of TB in natural populations, in conjunction with the development of superior diagnostic methods and laboratory studies, would provide further valuable insights into this relatively under-studied, and potentially zoonotic, disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Buffering with bicarbonate lowers renal oxygen consumption and reduces the amount of free oxygen radicals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most importantly, a significant difference in SF angiogenin concentrations was found between inflammatory and noninflammatory joint diseases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These reports and our findings suggest that DICER1 rs3742330 may impact the regulation of DICER1 expression, even if it shows a tumor-specific pattern, which requires laboratory-based functional studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because all the FtMs reported an early onset and almost all of them reported a same biological sex orientation, no comparisons could be made on this basis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reason is low percentage of ethnic minority groups in general population in Georgia19 as well as among PLWHIV (6%) (Georgian AIDS Center Database). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, in clinical settings where therapeutic drug monitoring is routine, a population pharmacokinetic model constructed using morphomic measures would likely only modestly improve empirical dosing due to the significant residual variability in our population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this clinical trial, we set FiO2 as 3, which was adequate to maintain the intraoperative oxygen supply and consumption balance, with no signs of decreased SpO2, ScvO2, or rSO2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If more than two dose reductions are necessary, treatment discontinuation should be considered7. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is no rule concerning the optimal timing of surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addressing absenteeism, ensuring that patients are aware of their rights to free essential drugs and services, and extending government subsidies to the dispensation of more drugs and ancillary care will improve both the quality and the uptake of public sector facilities closer to home, and reduce costs and delays for patients [28, 41]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The widespread dispersal of spores in a building has been demonstrated both by Q fever (disseminated through a large medical school building) (23) and by anthrax (dispersed through a post office with an area of 281,387 ft2 and a volume of approximately 7 million ft3) (40). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both high and low ABI are predictors for cardiovascular mortality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also evaluated relationships between objective (SOT and LOS) and subjective (DHI) measurements. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this study has limitations that must be considered when interpreting our findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this study was conducted with a relatively large population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These alternative expressions of weight are designed to approximate fat-free mass, although only LBW was determined experimentally using bioelectrical impedance and dual-energy X-ray absorptiometry (DEXA) (10). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies have successfully validated the roles of MC1R (38), CDKN2A (39), TERT (40) and ARNT/ SETDB1 (41) in melanoma disease risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such a difference can be a result of several factors: the type of surgery (open vs. laparoscopic), demographic parameters, stage of cancer, etc. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HLA genes in association with the gut microbiome may determine the immune environment and confer susceptibility to autoimmune arthritis (18). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mutations in OCA2 are known to cause oculocutaneous albinism type 2; however, the gene is also known to play a role in normal pigmentation variation and is associated with blue irises in European populations (42). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, rs3742330 may either directly or indirectly alter Dicer-mediated miRNA levels, which can influence mRNA transcription and CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contextual skills of all four eating competence subcomponents were most strongly associated with metabolic risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In centers that routinely perform this procedure laparoscopically, the number of lymph nodes harvested and the R0 resection rate are comparable [10,19,20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, those studies used relatively low doses of remifentanil, which may have limited its influence on OIH. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over the years, practice at St. Jude has changed so that TCAs are prescribed for NP as a second-line therapy after the maximum dose of gabapentin has been tried. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, abdominal hysterectomy performed with the cold knife procedure causes relatively little damage to the surrounding tissues. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies may still be needed to explore whether injecting an antibiotic in a pregnant woman with an increased NLR may reduce various neonatal complications and various sequelae of neonates accompanying histologic chorioamnionitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Q fever is also a recognized occupational disease in the United Kingdom (45) and governed by existing legislation (46), although it is not a notifiable disease (47). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a possible mechanism for the reduced pain after robotic hysterectomy, Chiu et al[17] explain that the chance of using the abdominal wall for leverage is decreased because the robotic arms pivot at the port sites and move/rotate around a fixed remote center-of-motion, thereby decreasing mechanical injury at the abdominal wall. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only retrospective data exist in this setting, and few of these studies provide an appropriate control group for comparison. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cremation forms must be completed by medical staff to prevent the inappropriate cremation of pacemakers. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, beliefs in Specific-Concern was not significantly associated with self-medication and total QAQ score although it was considered as one of the negative beliefs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is unclear whether these changes are preserved during longer walnut supplementation and how these changes are associated with the observed changes in lipid metabolism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, CD4 cell count is one of the indicators of disease progression in HIV/AIDS and therefore can potentially influence a person\u2019s self-perception of QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, in this prospective cohort of IBS-D patients who were not selected on the basis of prior response to a GFD, carriers of HLA-DQ2/8 actually had slower colonic transit than HLA-DQ2/8-negative patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in the subsequent warming blastocyst-transfer (BT) cycles of our study, we noted that the low oxygen group resulted in more favorable clinical outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this approach has been found to be often inadequate to attain long-term benefit (Keller and Boland, 1998; Montgomery and Kasper, 1998) and drugs that can be recommended for prophylaxis should offer good long-term tolerability at the full therapeutic dose. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to the 4 myxomas in this study, 1 thrombus and 1 malignant fibrous histiocytoma had attachments to the interatrial septum. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These patients are probably at the upper end of the coeliac disease fracture risk spectrum, but bone mineral density studies in coeliac disease suggest that as many as 40% of patients may have osteoporosis, with associated increased lifetime fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Administration of bicarbonate is safe as we did not see severe hypokalemia or hypernatremia in our patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After car ownership, age and gender may be the next most influential factors as studies found that women exercise less compared to men and that people are less active as they get older [70,71]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is a hypothesis we are currently testing in our paradigm. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed a higher case fatality among patients from poorer households, and while a multitude of factors undoubtedly contributed to this excess mortality, it underlines the urgency of reducing delays wherever possible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In view of these findings, the association between self-medication and beliefs in Specific-Necessity, General-Harm and General-Overuse could be attributed to the fact that patients with high positive beliefs about analgesics (Specific-Necessity) and low negative beliefs about medicines (General-Harm and General-Overuse) tend to perceive analgesic as a potential cure to dental pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether individuals are faced with addiction, serious mental illness, HIV/AIDS, or other disabilities (Rhoades, Browning, & Thorin, 1987), there is a value to increases in tolerance toward others and an esteem boost in relation to their own and society's perceptions of their conditions (Mayville & Penn, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A further limitation is that our study considered residential food environment only. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These characteristics are properties of an international high-risk clone (1) and underline that ST410 qualifies as a lineage with new international multidrug-resistant high-risk clones, which should be monitored closely in the future.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They are also in keeping with anatomically constrained magnetoencephalography, which has revealed an anterior temporal supramodal convergence area involved in word comprehension (Marinkovic et al, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One such intervention could be financial incentives for smoking cessation (Volpp et al, 2009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, the rate of patients who had had mammography screening was 13.3%, and the rate of patients who had never had any screening tests was 68.9%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our main finding is that only 4.7% of people with SMI were screened for HCV infection over a 1-year period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "3.0T systems have higher signal-to-noise ratio (SNR) and CNR than 1.5T [16\u201319]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the aim of a screening program is to provide a decrease in morbidity and mortality due to the target disease the screening tests should be inexpensive, easy to perform and accessible to everyone (Baskan et al, 2012). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fallers and non-fallers have greater gait variability than the young, as they are older, frailer, and in turn may not have the same intact sensory and motor function. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mongolian ethnicity in Russia, Republic of Mongolia, and Inner Mongolia of China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, low oxygen cultivation had more high quality cleavage-embryos and blastocysts available for cryopreservation, providing patients with more opportunities for achieving pregnancy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, during fibrosis progression, immune cells secret a variety of growth factors and inflammatory cytokines including IL-6, IFN-\u03b3, IFN-\u03b1/\u03b2, and IL-22, which have been shown to play key roles in regulating liver fibrogenesis resulting in collagen deposition and the disruption of the normal liver architecture29,30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These organizations have jointly issued a position paper advocating instrument-based vision screening for children between the ages of 6 months and 3 years 5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was problematic to use genes from the study of Nakagawa et al5 for functional annotation because those genes were selected on the basis of published evidence of their involvement in prostate cancer progression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estrogen administration in ovariectomized rats mutes glucocorticoid negative feedback, resulting in higher ACTH levels, whether corticosterone or a synthetic glucocorticoid is administered by single bolus injection to test fast feedback via nongenomic mechanisms (25) or infused continuously to test slow feedback via nuclear glucocorticoid receptors (4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The solubility of gases in liquids changes with temperature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unexpectedly, the association detected for the sequence variant nearest to MS4A4E (rs670139) and a test of delayed word recall in whites was in the opposite direction from expectation based on the association with AD in the GWAS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The differential effect of poverty on different age strata has more than one plausible explanation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there was no major difference in prediction capability between the two risk scores for all fractures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, BMIz trajectories in the first 2 years were associated with cardio-metabolic measures later in childhood, which in turn are known predictors of cardio-metabolic outcomes in adult life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In human colorectal cancer, the intensity of angiogenin detection has been shown to correlate with microvessel density and focal macrophage infiltration [40]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuous infusion of remifentanil during general anesthesia in minor surgery may not be superior to volatile anesthesia without opioid in terms of overall complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This treatment strategy may lead to more favorable outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CRP, produced by the liver as an acute phase protein, is a nonspecific marker generated in response to inflammatory stimuli. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, food vendor density within 400\u202fm buffer had a closer relationship with cardiovascular risk factors than density within 1600\u202fm buffer and distance to the nearest food vendor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such daily separation intervals are similar to our maternal separation paradigm, since rat pups were separated from the dam for 45 min total/day, much longer then is typical for \u201chandling\u201d paradigms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, pulmonary resection surgery has been advocated for selected patients who have localized disease and are able to tolerate resection to remove gross lesions that contain large numbers of bacilli (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One major limitation associated with the TSP approach, however, is that a large number of tests can lead to a large number of false-positive results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, analyses of 158 SNPs in 11 genes involved in AD including BIN1, CLU, CR1, and PICALM showed no significant association with cognitive phenotypes such as a test of verbal fluency similar to the WFT in 505 participants from the Lothian Birth Cohort of 1921(mean age 79.1 years) and 998 participants from the Lothian Birth Cohort of 1936 (mean age 69.6 years) [Hamilton et al  2011]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measurement issues pose challenges. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the NLR is limited in providing all necessary information as a predictive marker, it can still complement other inflammatory markers in predicting HCA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Examples of such interventions could be; training school teachers to identify social anxiety among students or recruiting a psychological counselor; emphasizing on group learning activities so that fear of talking with people could be minimized. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Especially, AFM showed a similar trend regarding the profile of na\u00efve and memory B and T cells, with significantly increased transitional B cells, CD4+ TCM cells and CD8+ TCM cells and significantly decreased IgD\u2212CD27+ memory B cells, plasmablasts and CD4+ RTE compared to HC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that maternal adiposity-related factors (ppBMI, GWG) were associated with BMIz trajectories reflecting larger child size (stable high-weight and rapid weight gain). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Phenotypic changes in repopulated B cells could account for this change in clinical course. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, when NPM/ALK expression was knocked out using an inducible siRNA silencing system, no significant evidence of BIM locus reacetylation could be found (Figure 6, C and D), suggesting that NPM/ALK expression is dispensable from maintaining BIM epigenetic silencing and that other, yet unknown pathways are required to maintain this process, probably involving DNMT1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ANP pretreatment reduces serum TNF-\u03b1 levels and NF-\u03baB activation by inhibiting I\u03baB-phosphorylation in mice injected with LPS (29) and has a protective role against LPS-induced lung injury and endothelial barrier dysfunction (30). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent study comparing three photoscreening devices showed Plusoptix to have good sensitivity and specificity compared to other devices. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the efficacy of intraoperative aprotinin in reducing postoperative bleeding seems confirmed by our results, its safety is still under investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was, however, a systematic tendency towards higher numeric improvements in the PA group, ranging from 2.6 to 4.9 points on HOOS-Pain, HOOS-PS and HOOS-QOL, than in the LA group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The characteristics of this Egyptian OXA-181/NDM-5-producing ST410 isolate correlate with the first OXA-181/NDM-5-producing ST410 isolate collected in Denmark, suggesting that the Danish patient, P1, most likely acquired the isolate during travel to Egypt in 2015. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Frequently, cross\u2010reactivity between species antibodies or elevated titers to more than one species is observed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results showed that the 8-cm H2O PEEP could better improve ventilation (maximizing the recruitment of dependent lungs and minimizing the overdistension of nondependent lungs) and oxygenation (avoiding impairing PaO2/FiO2 and increasing the shunt upon the initiation of pneumoperitoneum) in patients undergoing laparoscopic surgery, without significantly interfering with other respiratory or hemodynamic parameters. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Infection status and history, via effects on acquired immunity, may also lead to individual and population-level differences in experienced tradeoffs with growth. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, we used convenience sampling: HIV-patients were recruited at a medical facility by the physicians, which may have increased the possibility of selection bias or decreased generalizability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our current study, we have shown that subjects treated with oxandrolone had a significantly higher MVV compared to untreated subjects (Figure 2), and that subjects treated with oxandrolone had a significantly higher VEMax compared to untreated subjects during maximal exercise (Figure 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The variability in aminoglycoside clearance was best explained by using a modified Cockcroft-Gault equation, omitting terms for weight and sex, with the addition of a morphomic measure of skeletal muscle mass. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that additional study is needed to test interventions to achieve BP control in this group of patients, who represented 21% of the study population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the cardboard was only used for secondary packaging and was therefore not in direct contact with any food products. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should additionally be kept in mind that only the resting SPECT was repeated here for further comparisons of patient positions and that only patients with abnormal or at least doubtful stress SPECT findings in our current biker position could be included. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of laparoscopic surgery and ERAS is not inferior to open, traditional surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The agents used in the epidural space include an opioid and/or a local anesthetic, which can provide excellent analgesia with less systemic sedation (Desparmet, Hardart, & Yaster, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although abstinence attempts continued throughout the 3-month study, the incidence of new quit attempts decreased over time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After accounting for biological sex, age group, onset age, and sexual orientation, the hormonal therapy status should affect the Masculinity/Femininity and Psychasthenia scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The vibrating sandals improved gait variability in fallers, but they did not reduce variability levels in elderly recurrent fallers to the baseline range of elderly non-fallers or young controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Advising clinicians on the respiratory presentations of EV-D68 and alerting them to known active circulation will help improve current under-ascertainment and consistency of recording. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The model here does not explicitly contain such a parameter, but the pruning effect emerges naturally based on the fact that the value of uncertainty resolution is lower for the branches of the model that start with large punishments and therefore, they are more likely to be pruned. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, the increased tooth size discrepancy of anterior ratio in our sample supports the finding of other studies, such as Crosby and Alexander,34 Freeman et al,35 Santoro et al,36 Bernab\u00e9 et al,37 O\u2019Mahony et al,30 and Araujo and Souki,38 which found that the percentage of tooth size discrepancy in anterior ratio was more than the overall ratio (17.5% to 37.9% anterior ratio, 5.4% to 13.5% overall ratio). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No matter what protocol adopt, low oxygen cultivation indeed optimize patients\u2019 treatment outcomes to some extent. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite this potential overestimation of impairment when object knowledge is assessed by verbal responses, the percentage of anomias associated with word definition (i.e. comprehension) failures was significantly higher than the percentage associated with object definition failures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such isolated emergence of anomia in patients with atrophy confined to the anterior tip of the left temporal lobe has been reported previously and found to represent a prodromal stage of semantic PPA in some, but not all, cases (Czarnecki et al, 2008; Mesulam et al, 2012). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as a prospective study, the sample size of this study was relatively small, and further studies are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our clinical observations demonstrate that increased glomerular TNF expression in patients with FSGS correlates with reduced eGFR in the NEPTUNE cohort (Figure 3D) and with reduced ABCA1 expression in the ERCB cohort (Supplemental Figure 9), suggesting a role of local TNF in the pathogenesis of glomerular diseases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, breast cancer awareness was significantly associated with higher education and income levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These correlations are consistent with a recent study on infants and young children investigating relationships between white matter myelination and early learning composite as well as verbal and nonverbal developmental quotients (8). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, while psychological distress can be inherent to being transsexual, it could also be socially induced by the society, peers and family2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Training time needed for personnel to use the instrument was reasonable and the screening was well tolerated by pre-school children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite being well-powered to confirm the majority of true associations, and identifying GSVs at similar overall frequencies to the original reports, only one reported association was confirmed using a case-control approach. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hitherto aldosterone-to-renin ratio (ARR) is insisted to be a more valuable test than aldosterone levels for primary aldosteronism, and it could be an index for inappropriate aldosterone activity and salt sensitivity. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The proportion of asymptomatic relatives with reduced total IgG, IgM and/or IgA in the Iranian (13%) and Turkish (19%) cohorts was comparable to that in our cohort (8/47, 17%) 42,43. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether a goal of reduction only (example not in preparation for abstinence) should be accepted as a primary treatment goal among cannabis users is debatable (Lozano, Stephens, & Roffman, 2006). ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, even in this initial step, MPI poor adults took longer than non-poor adults to seek help (with equivalent delays among poor and non-poor children). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Somewhat disappointingly, however, despite ongoing participating center guidance and encouragement to enroll, only a minority of searches were included in the trial. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A delay of 2 months occurred between the dates when employees were probably exposed to C. burnetii and when environmental dust samples were collected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These scales can be considered neurotic-like, raising the question of whether MtFs are more neurotic than FtMs, because of stigma39. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accordingly, genetic analysis of heritable quantitative endophenotypes such as cognitive function that are often considered as intermediates in the causal chain leading from risk allele to clinical disease may help to uncover loci that increase or reduce susceptibility to dementia in its preclinical phase [Bennett et al  2009; Carmelli et al  2002; Gottesman and Gould 2003; McClearn et al  1997; Shulman et al  2010; Swan et al  1990]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our institutional experience also reflects the concept of multimodal pharmacological and nonpharmacological therapies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the common SNPs analyzed in this study may not be the causal variant even in individuals of European descent, and differences in linkage disequilibrium and allele frequency between whites and African-Americans could also result in variation in the ability to detect associations in non-European individuals as well as in the direction of effect. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alterations in jejunal mucosal TJ signaling have been described in IBS-D, but the relationship with HLA-DQ status was not previously investigated (25). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low oxygen cultivation had more embryos available for cryopreservation, providing patients with more opportunities for achieving pregnancy in subsequent cycles, and thus optimizing the treatment outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In SF, angiogenin was found in a wide range of concentrations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it is unclear if multiple introductions occurred, or if unknown carriers or contaminated environmental sources could link the spread between patients from these two PO10s. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be useful, in future, to explore the effects of our short duration stress paradigm on more complex assessments of cognitive function then the tests employed here and in our companion paper. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first study to examine the association between stress and severity of atopic dermatitis in an Asian population using national survey data. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The plasma homocystein levels is increas in arthritis [29].", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, the current results with cannabis users trying to change are very similar to those of our prior study of daily cannabis users (Hughes et al, 2008) and our prior studies of tobacco smokers using the same methodology (Hughes JR et al, 2014c; Peters & Hughes, 2009; Hughes et al, 2013). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, Ronco et al. [16] proposed that plasma NGAL may be useful in the diagnosis and prevention of CRS if a curve of plasma values rather than a single plasma measurement is determined. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that qualified doctors were more likely to recognize the potential seriousness of AFI, and warn patients of the possible need for escalation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cases 11, 12, and 13 had no current symptoms of bone disease but there was severe reduction in bone mineral density and a potential increase in these individuals\u2019 lifetime risk of fracture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Self-reported snoring and snorting/gasping each provide an aspect of sleep apnea. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients have identified under-staffing, poor physical facilities, behavior of service providers, and inability to provide essential medicines directly as causes of this low opinion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, the data shows that humans stop expanding a branch of the model once they encounter a large punishment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early detection and prevention are the most important control strategies of cancer in the twenty-first century. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Numerous studies have attempted to identify useful biomarkers for HCA through the analyses of amniotic fluid and maternal blood [11], [23]\u2013[25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Six case-control studies showed that dietary intake or serum levels of either lutein only30\u201332 or lutein/zeaxanthin33\u201335 were not associated with CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, we showed the activation of two distinct apoptotic pathways which could be proved to be an important contribution of the development of CRS Type 5 and might play a role in the pathophysiological mechanism of this syndrome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To maintain mobility in vertebrae that have not been grafted, in our study removing the metal is only indicated with long-segment dorsal instrumentation after ventral bony regrowth in the lumbar spinal region [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Education potentially provides opportunities for employment and social support, and thus can contribute to a sense of good QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "vur is equal to zero for \u03b3-values of zero and one, and reaches a maximum for an intermediate value of \u03b3 (its exact value depends on other parameters). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, diagnosis of HCA through histologic examination of the placenta is possible only after delivery; thus, the method is not suited for rapid prenatal diagnosis of intrauterine inflammation, nor can it be used in neonatal treatment in patients diagnosed with neonatal sepsis. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Changes in infragranular cortex are consistent with the literature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have previously described that Indian children had smaller birth sizes and lower BMI in infancy compared to Chinese children28; this may potentially explain the relationship between Indian ethnicity and a low BMIz trajectory, which is the result of BMI tracking. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that patients in the PA group reported having less limping than patients in the LA group, which may be explained by the disturbance of the abductor muscles (Masonis and Bourne 2002, Edmunds and Boscainos 2011, Amlie et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most common sensory deficit was vestibular, with 36% scoring in the abnormal range (Fig. 1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In that study, the SYS and NED groups both contained 213 individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first study showing that local TNF contributes to lipid-mediated podocyte injury in FSGS and DKD by a dual mechanism that requires both reduced ABCA1 expression and reduced SOAT1 activity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LUMA assesses methylation of a specific restriction enzyme site (HpaII, CCGG), which occurs most frequently in CpG island promoters \u2013 also covered by the 450 K array \u2013 but also in repetitive elements. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In support of the hypothesis that these relationships are driven by direct competition for energetic resources, negative associations between specific measures of immunity and growth were stronger when involving more costly forms of immune function and were evident only when examined over timeframes corresponding to synchronous energy use. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The retrospective nature of our present study did not allow us to specify the form of postoperative pain control and compare opioid demand. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, preoperative use of gabapentin may have a place in the treatment of postoperative pain (Dahl, Mathiesen, & Moiniche, 2004; Ho, Gan, & Habib, 2006; Milch, 2005) and has been given as a single dose (Dirks et al., 2002; Hurley, Cohen, Williams, Rowlingson, & Wu, 2006; Rorarius et al., 2004) or as an adjunct to epidural analgesia (Turan, Kaya, Karamanlioglu, Pamukcu, & Apfel, 2006). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adolescence is accompanied by rapid and varied changes in physical growth, sexual maturity, hormone levels, and psychological issues [33], [34]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The extreme weakness or apparent absence of one acetabular wall represents the only absolute contraindication for the use of this threaded component. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was necessary to avoid the pitfall of only including data of persons who could perform the measure, which would have biased the results towards those with a better outcome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the tendency of parathyroid hormone to reduce serum phosphate will decrease the calcium:phosphate product,20 further diminishing one of the important driving forces for mineralisation of bone osteoid. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 13 cases the displayed pH value was more than 8.00, and in seven cases the display showed only -.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pathways paired in predicting for distant metastasis were the xenobiotic metabolism and integrin-linked kinase (ILK) signaling pathways. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metabolic bone disease remains a significant and common complication of coeliac disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There may also be additional confounding factors we did not consider but that still affected the FA-BSID relationships. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study is a retrospective analysis of returned questionnaires. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multimodal pain therapy is effective (Citation, 2005), and a multimodal approach that incorporates newer therapies is generally accepted in clinical practice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We hope that these findings can stimulate further research on prayer in the field of CP clarifying the possible role of personal religious activities in the pain management of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This N400 abnormality was not present in a parallel non-verbal part of the experiment where object pictures were matched to other object pictures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a study by Przkora et al of oxandrolone and exercise in pediatric burn patients, it was reported that both the subjects with exercise training and subjects with oxandrolone and exercise training had significantly increased peak oxygen consumption [16]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are a number of anatomic and behavioral differences that exist between the rat and human. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, our measures in the rat model provide important insights that may further our understanding of Parkinson disease, the process of aging, and the influence of these on the intricate act of deglutition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anatomical differences relevant to deglutition between the rat and human are found in the oral cavity, pharynx and larynx. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All of these consequences were more common for poorer households. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, loss-of-function defects consistently occur in only a subset of periodic paralysis: those with features of hypokalemic periodic paralysis (HypoPP) due to mutations in Nav1.4 (28, 29). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, it is apparent that those who benefited the most from the intervention were those who were younger, those who did not have diabetes, those who had uncontrolled DBP at baseline, those who reported low salt intake, and those on fewer antihypertensive medications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our observation may be similar to Maria\u2019s. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The discovery and description of the mechanisms by which BIM, as well as other oncosuppressors, are inactivated in specific types of cancers may be of great importance to define evidence-based cancer treatment protocols. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the success rates of these medical treatments have peaked at 70-80% (10, 20), and the relapse rate in patients with sputum conversion at the completion of medical treatment is high (21). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the data need validation in a larger multicenter confirmatory trial. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for nosology Although this study is not about semantic PPA or semantic dementia, it should be pointed out that the semantic variant of PPA, in fully developed or possibly prodromal form, was detected in 7 of 11 patients and comprised the single largest diagnostic group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These mutations are independently distributed and heterozygosity for SLC4A1\u039427 does not influence heterozygosity or homozygosity for GYPC\u0394ex3. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we focused on the possibility that ANP indirectly inhibits tumor cell metastases through effects on nontumor cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our replication of the obesity association of deletions including SH2B1 and the finding of limited evidence to support 2 further associations, together with recent successes in other disorders including attention deficit hyperactivity disorder [43], demonstrate that analysis of carefully-selected cohorts has the potential to reveal novel, rare, causal GSVs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Osteointegration of the grit-blasted titanium surface is excellent and provides rapid secondary stability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Not surprisingly, the no-hormonal therapy group functioned psychologically worse than the hormonal therapy group (the Schizophrenia and Masculinity/Femininity scales in the FtMs, and the Psychasthenia and Hypomania scales in the FtMs). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The different association between both availability and accessibility of different food vendors with cardiovascular risk factor in different countries may be due to various social, cultural, economic factors which affect food sale, purchasing and consumption patterns (Turner et al, 2019). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No more than 5% of the patients referred to our department for myocardial perfusion SPECT are unable to complete this examination in the biker position, mostly because of extreme physical exhaustion or hip problems hampering their sitting astride the camera armchair. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As in other settings, only those patients likely to suffer mortality or substantial morbidity due to their disease should be considered for aggressive treatment, which should only be offered in the setting of an institutional-review-board-approved clinical trial or prospective registry. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our survey, a high proportion (70.7%) of the HCSs, enrolled in the study at the preventive medical examination, had persistence of seroprotective levels against HBV after more than 20 y since the administration of primary vaccination course. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides the significant increase of members of Ruminococcaceae spp. and Bifidobacteriaceae spp., our findings also showed a significant decrease of two representatives from the Lachnospiraceae family under walnut consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oxford House settings should not only be thought of as developing new reference groups, but also new family units, and this involves far more extensive interactions than mere social contact. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future efforts should take into account newer guidelines, the cost-benefit aspects, and the Hawai\u2018i-specific resources. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Antioxidant activity neutralizes the ROS and negates the effect on fertilization and cleavage rates in the first two cleavage divisions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The inferably suppressive effect of E2 versus placebo on ACTH secretion was confirmed by E2 concentration-dependent inhibition of ACTH secretion both in the combined cohort (48 adults) and in the women's cohort alone (n = 24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lung seems to be the target organ for SARS-CoV-2, and patients may develop acute lung injury and ARDS upon infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multiple multivariable adjusted logistic regressions analyses supported the roles of sleep habits, including sleep duration, daytime napping, snoring, snorting/gasping as significant risk factors for all stoke, ischemic stroke and hemorrhagic stroke. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Blinding of both the patients and the principal investigator performing the analyses was maintained almost completely throughout the trial, due to the nature of the self-reported outcomes and through the discretion of the hospital personnel. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant increases in the abundance of Bifidobacterium spp. and Lactobacillus spp. could also be observed in fecal samples as a consequence of both raw almond and almond skin supplementation [47]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was reported in this study that slightly more than one-quarter of the participants (29.4%) practised self-medication with analgesics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HMGB1 and IL-6 are involved in the pathogenesis of pandemic H1N1 influenza-associated encephalopathy, and the levels of these inflammatory cytokines in serum can be used as biomarkers for inflammation severity [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is no consensus about the optimal combination regimen, and a systematic comparison of regimens is needed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, if BMD is known, the clinical utility of these genetic risk scores for fracture prediction is limited in older adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The short chain fatty acid butyric acid is generated from fermentation of indigestible polysaccharides [30] and provides energy for intestinal epithelial cells and contributes to host health by facilitating maintenance of colon epithelial integrity and controlling inflammatory processes [31,32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When planning the study, we considered it as problematic from an ethical viewpoint to withhold these potent prophylactic regimes from the study participants at increased risk of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased attention must be paid to the metabolic, inflammatory, and hormonal pathways shaping obesity that interact with structural causes of poor energy balance [17]. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, metastasis-directed therapies such as SBRT carry a low risk of toxic effects and provide excellent local control. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BMI may actually predict sedentary behavior [20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This issue is relevant because it is unknown whether cardiac vein branches not visualized were not present because of venous anatomic variation or present but not visualized. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This case series further develops the efficacy profile of RTX and supports cyclophosphamide avoidance in appropriate patients by providing a rationale for use of a reduced dosing regimen of RTX in persistent pulmonary granulomatous inflammation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study adds to the growing evidence that untreated HIV-1 infection in men is associated with genital compartment inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nearly half patients (74/146) have hypokalemia in our study, but we found there was a linear relationship between LogARR and serum potassium. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The procedure may reinforce gender affirmation with better social recognition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A history of three well-defined previous episodes of depression within the last 5 years before study inclusion is required to obtain a patient sample with sufficient predicted morbidity to provide reasonable power for a comparison of relapse (Montgomery and Kasper, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This compared to rates in the literature obtained in 31,000 children of 12.1% for children aged 6 to 11 months and 1.1% for children aged 4 years 18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Likewise, the effects of maternal separation and temperature exposure in their respective impact on endocrine, morphological and behavioral changes will have to be differentiated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In any case, our results on NGAL values and its connection with outcome were limited for the small size of the study: in fact, a minimum of 25 events are required to draw reliable conclusion in case of outcome analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, more ETC + navigation participants who had initially said that they did not have a time frame in mind for quitting reported that they now had a time frame in mind for quitting, relative to ETC-control participants (37% vs. 7%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike typically found for \u201chandled\u201d rat, the animals in the study by Gibbs and Kolb did not show behavioral improvements by adulthood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because most current chemotherapeutic agents are cytotoxic and cause many side effects, chemotherapy cannot be used during surgical resection to prevent cancer recurrence. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Commensurate with this more pronounced defect in excitability, the leftward (hyperpolarized) shift for inactivation was much greater for V1442E (-30 mV, Fig. 5A) than the -10 mV shift observed for R672 mutants in HypoPP. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, despite its relatively high surgical complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been a poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, once introduced in animals, carbapenemase genes may be coselected by the use of other classes of antibiotics, which could increase the prevalence of CPE in animals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The level of CEAs reflects the degree of cancer disease and provides a reference for the diagnosis of the distant\u2010stage disease, evaluation of the prognosis, and monitoring the recurrence during the follow\u2010up 25, 26. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of aprotinin has been linked with a higher incidence of both perioperative myocardial infarction and early vein graft closure 26. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By applying the modified TSP approach to analyze the reported data from the largest retrospective study to date that has evaluated for an association between gene expression in primary tumor and disease progression after RRP, we identified two pairs of genes whose relative expression predicts such tumor progression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding has policy and practical implications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since 1999, psychological interventions (guided imagery, distraction, self hypnosis) have been introduced by a clinical psychologist during one session 5 to 10 days before LSS; patients and family members were then encouraged to practice on their own the specific interventions as taught by the psychologist. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the P-values for the trend analysis reflected a positive association with atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend that dentists should refer to relevant guidelines on prescribing analgesics for dental pain [28,29]. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar caveats should perhaps also be attached to the growing number of studies investigating common GSVs [36], [37], [39]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, study conditions are hardly comparable due to the different walnut serving sizes and varying study durations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the distribution of peripheral B-cell patterns among AFM was similar to that among IPH and IgGSD patients and indicated that some AFM have a defect in later stages of peripheral B-cell development. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Isolates from PO10-3 had an additional carbapenemase gene, blaNDM-5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The differences could be due to the use of different simpler visual method to describe the arch form, which include: ovoid, tapered and square. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To confirm this, we conducted a sensitivity analysis excluding those with diagnosed hypertension and diabetes, and the results were largely unchanged (Table SI and Table S2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interpretation of chlamydial antibody panels must be carried out carefully within the clinical context. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Where possible we relied upon comparison with published pediatric normal control studies (such as PWVcf), which lends itself to confounding factors such as inter-rater reliability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Malignant tumours of the breast, prostate or lungs carry the highest risk of developing osseous metastases in contrast to intra-coelomic tumours, the spread of which tends to remain in the abdominal cavity [11]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, these findings provide new insights into the etiology of LC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective, well-controlled trials are necessary and should aim to report outcomes in a consistent and systematic manner.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In agreement with data from Hosaka et al. [20], angiogenin was not detected in supernatants from 24h fibroblast cultures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We randomized the patients to a specifi c approach that automatically included a specifi c team of surgeons with skills in that particular approach, thus avoiding bias due to a learning curve. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also SNPs near the DIO2 (deiodinase, iodothyronine, type II) gene and recently identified DOT1L gene was suggested to play a role in OA [7,22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, arch dimensions, forms and Bolton ratios were assessed directly on models of patients seeking orthodontic treatment and who had different types of malocclusion, which makes the sample more representative of Jeddah\u2019s population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the most recent studies, which were conducted with larger homogeneous samples of highly selected transsexuals (i.e., those who were eligible for a standardized sex reassignment procedure) and/or using the MMPI-24,7,10,25, the results were consistent with ours and support the view that transsexualism is usually an isolated diagnosis5,7,8,10,25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, any genes and polymorphisms don\u2019t play roles in the development of disease independently. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Afterward, several studies tried to detect any significant differences in Bolton\u2019s ratios between both genders, and other studies measured the differences in Bolton\u2019s ratios of various malocclusion groups 28-32. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the absence of evidence in our data to support this phenotype reopens the possibility that haploinsufficiency of one of the other genes in the region is responsible for the observed GSV-associated obesity phenotype (although SH2B1 remains a strong candidate). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, several studies have reported that laparoscopic surgery may be more painful because of the greater abdominal wall injury than robotic surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Probably, cellular apoptosis occurs in all CRSs and involves different types of cells and, therefore, different tissues. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, when emotion dysregulation and dispositional mindfulness together were regressed onto social anxiety, correlations with age and sex remained significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study indicate that lutein/zeaxanthin affects miRNA processing by regulating DICER1, which appears to result in a lower CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless several conclusions are possible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that older animals are slightly more likely than younger animals to have early stage infections (with no cutaneous lesions that have ulcerated through the skin), but are much more likely to have advanced stage TB. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, further validation in further independent data sets, with a greater sample size may increase the power sufficiently to detect possible associations between methylation of individual loci and age at menarche. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These suggest that enhancing eating competence may contribute to weight loss and subsequently, improve the metabolic profile of an individual. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In keeping with international studies, most patients followed a pattern of escalation from sources nearest the home, most accessible, and least expensive, toward greater professional expertise and more intensive management [33]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Experiments in animals have identified reproducible effects of gender and/or sex steroids on the regulation of the hypothalamo-corticotrope-adrenal axis (4, 5, 37, 41, 42). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that, in podocytes, irrespectively of the amount of esterified cholesterol that accumulates, cell injury is mainly caused by free cholesterol. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, one important limitation of our study was the lack of information on other early life exposures, therefore it was impossible to investigate whether such exposures confound the observed association between age at menarche and DNA methylation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides, atopic dermatitis' severity was also considered by including the information on the number of absent school days due to atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, longitudinal analyses may further clarify the relationship of age to the vasculopathy of HGPS in future studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, a high concentration of NO is associated with chronic inflammation and tumorigenesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data on prophylactic efficacy of different prophylactic strategies are conflicting and there is a lack of data investigating potential synergistic effects of prophylactic measures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This hypothesis was further supported by the evidence that NPM/ALK is able to activate an epigenetic STAT3-dependent pathway [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, our results uncover a novel mechanism where cholesterol-mediated podocyte injury is the result of increased endogenous TNF expression, thus possibly contributing to the development of FSGS and DKD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering expected rates around 50% in patients receiving no continuation treatment (Prien and Kupfer, 1986) on the one hand and a certain \u2018therapeutic\u2019 effect in the placebo group (Montgomery, 1999) on the other, our assumption appears to be well founded, but it will also be reassessed (and modified if required) during a blinded data review that is part of the trial\u2019s biometrical concept. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Notably, this mechanism was demonstrated in NPM/ALK-positive cell lines [19], suggesting that the impairment of the BIM pathway is an important step in lymphomagenesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, although there was no overlap with the variants identified in whites, there was nominal evidence for association of rs1476679 (ZCWPW1) with greater decline in verbal memory and of rs3865444 (CD33) with reduced decline in verbal fluency in the smaller sample of African-Americans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The optimal anamnestic response to HBV booster vaccination observed in non-seroprotected subjects further confirms the capability of the vaccine to create a strong immunological memory. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the Lasso method, the results emphasized the role of snorting/gasping in elevating stroke risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pure interface anomias, where object and word were both defined but not matched, were very rare. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physicians entitled to sign forms B and C must be aware of the legal and financial responsibilities of certification and the consequences when pacemakers are heated. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, we report the first epidemiological study to comprehensively evaluate genetic variation in genes involved in mitotic regulatory pathways and breast cancer risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, participants may have received mechanical vibrations below 90% of their sensory threshold. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current study has produced novel results among Nepalese adolescents, with results that are a first step towards finding a way to reduce the incidence of social anxiety for this population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The first is the small amplitude of longitudinal cardiac motion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study thus contributes new knowledge, and has several strengths. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates the ability of sub-sensory mechanical noise delivered to the soles of the feet through vibratory sandals to reduce stride, stance, and swing time variability in elderly fallers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DICER1 plays a role in a biogenesis pathway that is known to regulate the repression of mRNA translation and trigger mRNA degradation by binding to the 3\u2032-untranslated region (UTR) of target mRNA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Death due to severe myelosuppression, rhabdomyolysis, acute renal failure, or respiratory failure attributed to treatment occurred infrequently10. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for nursing care to provide optimal pain management for children undergoing LSS emerge from the concept of a rational multimodal approach to include pharmacological, behavioral, and rehabilitation principles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, accurate calling of smaller GSVs spanning only a few probes remains problematic, despite ongoing improvements in methods for GSV detection [19], [33], [34]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, failed quit attempts predicted an increased, not decreased, probability of later quit attempts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present prospective randomized study conducted with the D.SPECT CZT camera, attenuation artifacts were shown to be strongly reduced in patients positioned in a semireclining bikerlike position comparatively to the more conventional sitting and supine positions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this context, the investigations of the role for MCP-1 gene polymorphisms should be directed at wider range of SNPs and take into account haplotype combinations [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The onset of analgesia occurs as early as the third day for most patients (McClain & Ennevor, 2000). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rodents are considered an important potential source of C. burnetii, and in one U.K. serosurvey, 34% of wild brown rats (Rattus norvegicus) had antibodies suggesting previous exposure to C. burnetii (20). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is also often viewed as a nonclinical dimension of the MMPI7. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is consistent with the literat\u00fcre (Aydin., 2004; Canbulat., 2006) and suggests that those participants actually did not have enough information about the benefits of BSE, which is why they are less likely to seek health care. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, one could speculate, that early postnatal stress effects may increase synaptic complexity in supragranular cortex but also confer vulnerability to subsequent adult experience such as behavioral testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, there is a danger that reported associations may include a large number of false positives. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provided nominally significant or suggestive evidence for an influence of CR1 on immediate recall in African-Americans, and of CLU on paragraph delayed recall in whites using the Logical Memory subtests from the Wechsler Memory Scale-Revised [Pedraza et al  2014]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since it is against the code of practice of crematoria staff to open sealed coffins, they depend on others to provide accurate information. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, use of contrast media results in additional study cost as well as potential side effects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally perhaps, initially alcohol and drug use declines but then increases with longer duration of abstinence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caspase-3 is activated by the upstream caspase-8 and caspase-9, since it serves as a convergence point for different signalling pathways. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the study of Dinesh et al based on Indian population about the effect of NK2 homeobox 5 SNPs on CHD, NK2 homeobox 5 c.608A\u200a>\u200aG (p.E203G) and c.852G\u200a>\u200aA (p.N226D) polymorphisms were counted to be associated with CHD[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In light of this limitation, we make the following recommendations for considering an aggressive treatment approach for men with known metastatic disease. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A significant association was observed between education and QoL in our study: persons with higher education (e.g. those who finished University) were more likely to have good general QoL as well as better QoL scores in the physical, environment, and independence domains as compared to those with low education. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of our study confirm a substantial variation in the cardiac venous anatomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, aldosterone-induced renal injury was reported, we should actively observe the dysfunction of paranephros in early stage of primary kidney disease included serum aldosterone, PRA, and imaging examination was necessary also. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover serological screening, of all HCSs, and administration of booster HBV vaccine doses when needed, are preventive policies particularly meaningful in the current period when foreign students coming from countries with potential gaps in the immunization programs or coverage rates could increase the reservoir of young susceptible workers exposed to biological risks. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In some cases, the benefits reflected in embryo quality and clinical outcome [24], in others improvements were found exclusively for pregnancy or implantation outcomes, but embryo quality was not affected [19], and in others, improvements in embryo quality [18,25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the routine placement of a warning label on the front of all the clinical notes of people with pacemakers and other implantable devices would alert the physician to the presence of potentially explosive material in the body.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with this hypothesis, we have presented the preliminary results of the effects of a diet-intervention, randomized, controlled study of gluten exclusion on symptoms (bowel function), intestinal barrier functions (permeability and TJ expression), and morphology in IBS-D patients, and we have demonstrated deleterious effects of gluten, which were aggravated in HLA-DQ2/8-positive patients (33, 34).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study was limited by the small number of children screened, and by the initial need to train personnel and to establish the optimal environment/setting for such screening at different locations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The trajectory patterns observed in our study are consistent with those reported in previous studies by Magee et al13 and Ventura et al15, which also identified four BMI trajectories in childhood using LCGMM. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our approach could also be useful during drug development consideration and may be directly applicable to population pharmacokinetic modeling and dose determination for investigational aminoglycosides, such as plazomicin (11,\u201313). ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here, we showed for the first time the existence of a BIM epigenetic silencing mechanism in NPM/ALK+ ALCL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher reports of non-acceptance of emotions and lack of clarity were associated with increased social anxiety, as well as having less difficulty with emotional awareness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In some of the previous studies of this association, general QoL differed across both gender and age categories.7,9 Generally, older people are expected to have worse QoL due to the factors related to ageing (physical conditions, fears about the future); however, HIV-associated stress level did not differ by age.17 Further stratification of our sample by age showed a significant difference in ARV status: 85% of older patients and only 73% of younger individuals were receiving ARV treatment (p\u2009=\u20090.04). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pacemaker explosions can damage the cremator, breaking doors or brickwork. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar considerations may apply to rs1476679 (ZCWPW1) and to rs3865444 (CD33) where addition of the minor allele was associated with greater 6-year decline on the DWRT and decreased scores at baseline on the WFT, respectively, in African-Americans but decreased susceptibility to AD [Lambert et al  2013], and to rs4147929 (ABCA7) and rs6656401 (CR1) where addition of the minor allele was associated with higher scores in whites on the DWRT and in African-Americans on the DSST but with increased risk of AD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the plethora of immunological abnormalities and their unequal distribution among different cohorts have made it challenging to uniformly identify subgroups in the CVID population 10,46\u201348. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed that surgical treatment for liver metastasis was an independent prognostic factor for CRC patients with liver metastasis (HR = 0.212; 95% CI = 0.056\u20130.808; P = 0.023) as patients who underwent resection for primary tumor together with surgical treatment for metastasis had a better survival than other hepatic metastatic patients (3 year OS, 70.8%, 43.8%, and 4.5%; P < 0.001; Table 2; Figure 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As our short-term and long-term mouse models demonstrate efficacy of HPBCD and ABCA1 overexpression, it seems feasible to propose that HPBCD or drugs that increase ABCA1-mediated cholesterol efflux may represent a new class of drugs to treat patients affected by proteinuric glomerular disorders. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over the next twenty years it has become evident that the laparoscopic approach, although feasible, is associated with important drawbacks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These white matter regions surprisingly were not specifically in the major white matter pathways involved in these functions; for example, frontal or prefrontal white matter for cognition, superior longitudinal fasciculus for language, and cerebral peduncle and posterior limbs of internal capsule for motor functions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, while the case-control design had the superiority of being cost effective, resource and time efficient, potentially subject bias could have been introduced by patient recall, and causal associations cannot be inferred given the nature of the cross sectional design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, AFM had, on average, normal levels of cTfh cells, NK cells, and dendritic cells (total and subsets). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive relation between maternal adiposity-related factors and child size has been reported in other populations39, 40, as well as in our own cohort27, 41. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, MTHFR gene C677T mutation has never been investigated in OA in any ethnic group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The only comparable study we were able to find investigated associations between static (quiet stance) and dynamic balance tests (timed up and go, tandem gait, and the dynamic gait index) and DHI scores.37 Their findings showed even stronger associations between dynamic tests and DHI than between static tests and DHI in those with balance problems from multiple disorders including TBI.37 Our sample was restricted to TBI, and therefore provides higher generalizability to this specific disorder. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subsequent hysterectomy within 1\u20132 weeks after conization should be avoided, except under special circumstances. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A decrease of viability was observed also by Virzi et al. [17] in monocytes incubated with plasma of CRS Type 1 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study we founded high concentration of pro- and anti-inflammatory cytokines in CRS Type 5 plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, satellite and SINE repeats were found to be enriched with hypomethylated Differentially Methylated Regions (DMRs) whereas LINE was enriched with hypermethylated DMRs in malignant peripheral nerve sheath tumours compared to normal Schwann cells [30]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eysel and Peters [3] found that, even in spondylitis, a single ventral operation with ventral instrumentation is possible without increased complication rates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, an important limitation of these examination methods is that amniocentesis, an invasive procedure, is unavoidable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, inspection of the original overall P-values for each GSV (Table 1: reproduced from or calculated according to the original reports; see Text S1) shows that even a moderate correction to the threshold for significance to account for these multiple tests would have excluded the majority of the reported loci. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have suggested that only high doses of remifentanil infusion cause rapid opioid tolerance and/or hyperalgesia5,19,31. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Currently, postoperative epidural analgesia uses bupivacaine 0.1% to 0.125% and fentanyl 3 to 5 mcg/ml for 3 to 5 days. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chiribiri et al. [9] retrospectively evaluated the feasibility of contrast-enhanced SSFP CMRA at 1.5T to depict the anatomy of the cardiac venous system in 23 subjects and found the CS in 100% of subjects, the PIV in 96%, the PVLV in 78%, the LMV in 70%, and the AIV in 65%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the third week after conization was probably the patients\u2019 menstruation period, fewer hysterectomies were performed during that time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies of insurance schemes in Bangladesh have identified benefits in terms of access to basic and preventative healthcare, but found that insured households are not protected from the catastrophic expenses of severe illness, necessitating hospital admission, where the costs of interventions and supportive care are not covered, and can escalate steeply [47]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our patients, healing without complications was observed after a revision involving the removal of the dorsal instruments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre or neo-natal nutrition as well as early life exposure to endocrine disrupting chemicals (EDCs) can also lead to hormonal imbalances impacting on age at menarche [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When tested with the more sensitive IDI and continuous NRI (>0) reclassification metrics, GRS63 significantly, but modestly, improved the base non-BMD-adjusted model in all three cohorts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some studies showed that BSE provided no decrease in mortality rates (Lee et al, 2010; The Canadian Task Force on Preventive Health Care, 2011) In contrast to these studies, before the routine mammography examination, 65% of women between 40 and 45 years of age noticed breast cancer by themselves (Harvey et al, 1997). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the recommendation of the LOS test as an additional assessment in the evaluation of individuals who report chronic balance difficulties after a mild to moderate TBI.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative infection is one of the most common complications following hysterectomy, not only threatening the health and life of patients but also affecting the quality of medical care. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is unclear if and how the changes in the microbiome are linked to the observed changes in fasting lipid metabolism [9]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Each of these defects occurs because of the tendency for the excessive activity mutant channels to depolarize the cell. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because the incidence of both C. trachomatis and C. pneumoniae is high, it is also possible that simultaneously elevated titers represent previous exposure to both pathogens. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigations are required to understand whether agents facilitating podocyte cholesterol efflux maintains their beneficial effects in the setting of established CKD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "[20,21] The occurrence of CHD results in fetal abortion and newborns death, meanwhile, it puts a heavy burden on the economy and life of family. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For validation, we used data from studies that had much smaller sample sizes, but because we validated only the top 22 gene pairs, false-positive results were not a serious concern. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, inferable T effects are positive when covaried with E2 effects under the same conditions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Screening with bone densitometry is helpful in detecting patients at risk of fracture,[citation] and as shown in cases 6, 9, 14, and 15 the presence of severely reduced bone mineral density is associated with fracture at these sites. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than 70% of female population must be included in the screening programs to reach the targeted aim of \u201cdecreasing the mortality of breast cancer\u201d. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hysterectomy should be performed at least 4 weeks after conization, and treatment with iodoform gauze after conization can be beneficial.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observation that HLA-DQ2/8-positive patients had slower colonic transit at 24 and 48 h was unexpected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A previous experiment with NOMINA found greater intra-category blurring for natural kinds in patients with semantic PPA with somewhat more extensive and bilateral peak atrophy sites that spread further into the parahippocampal, inferotemporal and fusiform gyri than in Patients S1\u2013S11 (Mesulam et al, 2009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The inflammation is the probable cause for elevated D-dimer levels, and may also be a sign of acute lung injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mean BMI of participating drivers is 32.3 kg/m2 (Obese \u2013 Class I), with 59.8% of drivers being obese, compared with just 27.9% of the Australian population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that although EV-D68 has been historically seen in the UK, there has been a comparative increase since 2014. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most well-powered twin and family studies demonstrate that there is also a substantial heritability (40-50%) of BMD change (8-10). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evidence of vascular dysfunction is apparent in 100% of our cohort, in children as young as 3 years of age. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although seminal plasma HIV-1 RNA levels are greatly decreased by ART, a substantial subset of patients continue to have intermittently elevated seminal plasma HIV-1 RNA levels and remain at risk for transmitting to their sexual partners. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chronic infection with the HBV is associated with an increased risk of LC and HCC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The argument could be advanced that pictured objects are easier to recognize because the shape of the object contains clues related to its function through the phenomenon of affordance (Hodges et al, 2000). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study shows that many of those surveyed believe that such a device could be useful. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, an optimal capability of the HBV booster vaccine to elicit a strong anamnestic immune response was demonstrated, particularly in subjects receiving the primary immunization course during adolescence.19 Indeed, in our study, more than 95% of subjects receiving an HBV vaccine booster dosed demonstrated a seroprotective anti-HBs antibody titer after 2 weeks from vaccination, and all subjects vaccinated in adolescence reached a seroprotective anti-HBs antibody titer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results extend the prior analysis and demonstrate that there were some significant differences in intervention effect across demographically and clinically defined subgroups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we know of no studies of the validity of self-reports among cannabis users in non-treatment settings, studies of alcohol (Del Boca & Darkes, 2003) and tobacco (SRNT Subcommittee on Biochemical Verification, 2002) users in these settings suggest self-report is accurate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In CRS Type 5 contest, systemic disorder was often accompanied by systemic inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We confirmed our prior observations (29) and other reports in the literature (17, 25, 28) that IBS-D patients have increased SB permeability compared with healthy controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the aberrant DNA methylation pattern observed in adulthood might not be related to menarcheal age per se but to an early life environmental exposure, like diet, that impacts both on age at menarche and on DNA methylation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also conducted tests for association with BMI as a quantitative trait, for those loci at which GSVs were identified sufficiently frequently in our population cohort (for which there was no prior ascertainment on the basis of obesity). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Within a community framework, mental health and tolerance increases may be seen relevant to concerns of stigma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it is not surprising that the problems listed, in particular performing ambitious and strenuous activities, were found to be strongly related to deficits of timing and excursion in the LOS test. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants perceived financial constraints as a major cause of delays in seeking healthcare. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "People living with HIV who received ARV treatment were more likely to have good general QoL, as well as better physical and social QoL as compared to those not using ARV drugs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Demand-side financing has been introduced to promote maternal health in rural Bangladesh, by providing credit vouchers in advance of need for health services. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although our findings are only observational, the results indicate that nuts (especially walnuts) may represent an important dietary supplement not only to positively influence blood lipids but also to improve gut microbiome health. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Keeping in mind that over 45% of the students in our sample qualified for the free and reduced lunch under the U.S. National School Lunch Program, a frequently used marker of family poverty, this is encouraging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications of the Study Inhaled organic particles are an important source of a number of occupational diseases (17,42), and risks from exposure to occupational dust have been addressed by the U.K. Health and Safety Executive (43,44). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This showed a narrower arch form than normal in this specific Saudi sample, which should be considered in the selection of the preformed orthodontic arch wires in the treatment of orthodontic patients in the city of Jeddah. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, complications after opioid administration included nausea, vomiting, dizziness, urticaria, constipation, and sedation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, we excluded dependent alcohol users. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accordingly, the extract and assessed schedules should be recommended for preseason immunotherapy of pollen allergic patients or other cases in which an early reach of the maintenance dose is beneficial. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One explanation for this result may involve sex-related differences in stress-related HPA axis reactions to psychological stressors [29]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar to our prior study (Hughes et al, 2008), almost all attempts to stop or reduce cannabis lasted less than a week, and many did not last more than one day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 2015, Beamish et al. published the systematic review of fourteen trials (nine randomized and five non-randomized) comparing ERAS and non-ERAS gastric cancer surgery [39]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that there were no significant differences in age or uterine volume, length, width, and thickness among the 3 groups, and that certain other factors, such as a history of pelvic surgeries, severe pelvic adhesions, inflammation, and other combined diseases (such as diabetes and thyroid diseases) related to induction of infection that could affect the occurrence of complications after hysterectomy were excluded, these results indicate that the time interval between cervical conization and posterior hysterectomy, rather than other factors, influenced the expression levels of inflammatory factors (TNF-\u03b1, IL-6, and HMGB1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because it does not appear to significantly affect hematopoiesis, gabapentin may be the drug of choice for children with cancer and NP. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As shown by the cross-sectional study, the diagnosis of TB based on external lesions vastly underestimates TB prevalence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor healthy eating and physical activity behaviors are known risk factors for overweight and obesity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Statistical Power and False Discovery Even after enrichment by selection of an appropriate discovery cohort, and testing only for rare GSVs with dominant phenotypic effects, low statistical power remains an important issue, with increased rates of false negative and false positive associations at a given significance threshold and inflated estimates of effect size (\u201cwinner\u2019s curse\u201d) [20], [31], [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, 63% of women and 72% of men in Finland have BMI > 25 [34], and the study population represents a wide range of at-risk individuals with different backgrounds. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oxandrolone has been shown to increase net muscle protein synthesis in healthy men [18] and in burned children [19], which may explain the beneficial effects of oxandrolone on lung physiology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is rather the experience of the surgeon and the center that influences clinical outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In developed countries, HCV, alcohol misuse and nonalcoholic liver disease are the most common cause of LC; whereas the leading causes in sub-Saharan Africa and most parts of Asia is HBV4,5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reports of increased acting with awareness, not reacting to inner experience, and being able to describe inner experience were associated with lower social anxiety, as was more social support from close friends. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were no excessively high degrees of astigmatism or hyperopia recorded by the Plusoptix S12 photoscreener. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All 4 myxomas in this study were noted by TEE to be attached to the interatrial septum, at or near the fossa ovalis, which is the most common site of attachment for atrial myxomas&l() and is 1 criterion for the diagnosis of myxoma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estrada et al evaluated the ability of GRS16 to predict prevalent fractures in a cohort of only women (n=2,836; (15)), whereas the present study evaluated the ability of both GRS63 and GRS16 to predict incident fractures in more than 8000 elderly men and women. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, density of fruit and vegetable vendors was inversely related to fasting glucose only, but not insulin or other obesity related outcomes (BMI, waist circumference, and waist-hip-ratio). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, whereas we simply assume here that planning and action execution cannot be performed in parallel, it is reasonable to assume that agents deliberate over upcoming choices while performing previously chosen actions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evolution of a systemic coagulopathy is indicative of a poor prognosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gabapentin is started 1 to 3 days preoperatively to allow plasma drug level to rise before surgical trauma to the nerves, at a dose of 5 mg/kg/day divided into three doses every 8 hours; after surgery the dose is increased every 2 to 3 days as indicated for neuropathic symptom control. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is further supported by the global analysis, where the Danish outbreaks cluster in distinct clades (Fig. 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During preimplantation period, several important events occur, including 1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Healthcare providers have noted consistent problems with drug procurement and supply. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For pO2, CDI estimates were inaccurate, however with a level of precision comparable to the calibrated measurement series, corresponding to the introduction of a bias. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show that eating competence associates with a healthy diet and higher level of physical activity, which have been associated with a lower risk of type 2 diabetes [35,37]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Myocardial perfusion images from the D.SPECT camera are enhanced for patients positioned in a forward-leaning biker position rather than in the more conventional sitting or supine position. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, none of the associations observed between cognitive function and the AD GWAS loci remained significant after Bonferroni correction for multiple comparisons. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For both 6-year cognitive change and cognitive performance at baseline, there was no overlap between the significantly associated variants identified in whites and those detected in African-Americans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some evidence exists that a number of cases of Q fever were occurring around 1950 in the English county where the straw board was manufactured (17) and that the straw board was probably manufactured from 1950 to 1953. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous contrast-enhanced CMRA study at 3.0T using 12-channel coils [13] had reported reduced acquisition time compared to conventional SSFP CMRA at 1.5 T [15] (9 min vs. 13 min). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When tested with a comprehensive battery used for the quantitative characterization of PPA, all patients displayed a major impairment of object naming on the Boston Naming Test. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that the LUMA based association is being driven largely by methylation differences in repetitive elements, where age at menarche could have a greater effect. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A wide variety of subscales was also introduced over many years to help clinicians interpret the results of the original clinical scales, which had been found to contain a general factor that made interpretation of scores on the clinical scales difficult55,56. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relationship of glycophorin C or band 3 mutations to malaria susceptibility has been investigated [13,20,24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The normal segmental uptake of the same proximal and median portion of the anterior wall was found even higher with the sitting position (Fig. 2), strengthening the general consideration that the different patient positions lead to specific attenuation patterns and are thus not interchangeable for further patient monitoring. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physical therapy sessions are held daily during the inpatient postoperative period, and 3 to 5 sessions per week are required after discharge. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, based on previous studies (Keefe et al, 1990) as well as on theorizing that there are multiple forms of pain outcomes (Wachholtz & Pearce, 2009), we distinguished between pain severity and pain tolerance, with the latter indicating how pain impacts on the CP patient\u2019s ability to maintain their general activities of daily living. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although attempts were made to take account of multiple testing (e.g. exclude GSVs present in the Database of Genomic Variants, including only rare GSVs, empirical estimate of FDR), it is unclear to what extent these methods are effective \u2013 methods developed for association analysis of rare sequence variants are not consistently well-powered even for large sample sizes [42]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possibly, genetic and/or environmental elements predisposing to the development of PAD may be more prevalent in the general community than initially thought. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While there are limitations with the current EV-D68 surveillance activities in Wales, there has been consistency in the testing approach and the inclusivity of all patients tested for acute respiratory infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent studies indicate that postoperative complications, including severe inflammatory reaction and infection, after various types of cancer surgery are associated with poor cancer-specific survival (24\u201326). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Periodic paralyses stemming from mutations in SCN4A present later in life, the attacks typically spare cranial, bulbar, and respiratory muscles, the serum potassium level increases or declines during attacks in most cases, mild exercise for brief periods does not decrement the CMAP, and the resting membrane potential of the muscle fiber is decreased when action potential generation fails (27, 28). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We were unable to link patient P1 to the other patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Close attention to the anatomy of atrophy in the individual patient at the time of the neurocognitive evaluation may help to resolve apparent inconsistencies in nosology, and to further clarify the functionality of anterior temporal neocortex.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on our results, a FiO2 of 3 was appropriated for most American Society of Anesthesiologists class I to II patients while avoiding the potential deleterious effects of both hyperoxia and hypoxia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An awareness program for teachers and parents aimed at making them aware of and able to assess adolescents\u2019 relationships with their classmates, close friends, teachers, parents, neighbors, and relatives, may help adolescents strengthen their relationships and create favorable environment for adolescents to seek social support to act in adverse conditions. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The blastocysts derived from high oxygen cultivation may be accompanied by compromised development ability, which may be related to the fact that alterations derived from the maternal genome during the pre-compaction stage at different oxygen concentrations may have a far-reaching influence on the embryonic genome, resulting in differences in subsequent embryo health and developmental potential. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Examples are using \u2018cached\u2019 values of actions instead of recalculating them at each decision point [18], or using \u2018action chunking\u2019, in which actions span over multiple future states [23]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Grunnet et al. [24] showed that the extrinsic pathway may activate the intrinsic pathway to induce cell death through caspase-8-mediated cleavage of the BH3-only Bcl-2 protein Bid. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results may coincide with the findings of Rinaudo et al. [17], who showed certain beneficial effects for faster embryo development and increased cell number if cultured at a low oxygen concentration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was most likely due to the strict patient selection, which excluded patients with many comorbidities and the intraoperative protective lung ventilation strategy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tricyclic antidepressants have demonstrated analgesic efficacy for NP entities such as post-herpetic neuralgia and diabetic neuropathy, and their use is extrapolated to other NP entities (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002); they were found to be useful for phantom limb pain in children as early as 1989 (Rogers, 1989), taking effect within 1 week at doses lower than those required for depression (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, there is an urgent need to identify effective interventions for the prevention and control of hypertension in Xinjiang. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To further characterize the molecular events leading to chromatin condensation, we performed ChIP experiments using anti-HDAC1, HDAC2, HDAC3, MeCP2, MBD3, Kaiso, and NCoR antibodies, demonstrating HDAC1, HDAC2, and MeCP2, but not HDAC3, MBD3, Kaiso, and NCoR, to be involved in BIM silencing (Figure 5, D and E). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach is highly dependent on labeling techniques; therefore, our observation suggesting no differences according to HLA status may not have functional relevance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This small uncontrolled study is the first Hawai\u2018i-specific experience with early childhood vision screening using a portable hand-held photoscreener. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increases of IL-6 levels have been reported to correlate with increased fibrinogen levels, confirming the link between inflammation and procoagulant changes of the hemostatic system 27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bone fracture was seven times as common in coeliac disease patients as in controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The defect described herein is a more extreme example, with complete failure of action potential initiation by a normal EPP (Fig. 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we know of no test of this among cannabis users, most studies using IVR (Helzer et al, 2002) or Ecological Momentary Assessments (Shiffman, 2009) have failed to find reactivity with alcohol and tobacco users. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the two-route account, hubs of the language and object networks would have to interact with each other through reciprocal connections to enable object naming. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a previous one-year weight loss intervention, eating competence increased as BMI decreased among obese individuals [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Loss of function in heterozygous DICER1 germline pathogenic variants and somatic missense variants of DICER1 result in the abnormal production of miRNAs41\u201345. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Supernumerary optimal embryos, these are cryopreserved and transferred in subsequent cycles can improve the overall pregnancy rates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanisms associated with these cortical changes may have relevance for the further understanding of, and subsequent therapeutic approaches to a number of different mental health disorders. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Potential Contamination of the Straw Board Straw board could have been contaminated either before or after manufacture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accordingly, Martino et al[18] showed that patients with endometrial cancer who underwent robot-assisted hysterectomies required a fewer analgesics and had less severe initial postoperative pain than did those who underwent laparoscopic surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, not a single trial showed any difference in the readmission rate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, while allele frequencies for GYPC\u0394ex3 were higher in the Wosera than Liksul, the distribution of these alleles was in Hardy\u2013Weinberg proportions in both populations and suggests that GYPC\u0394ex3 alone does not confer a selective disadvantage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data also support a role for TNF in activating NFAT signaling leading to altered cholesterol metabolism via reduced ABCA1 expression, thus contributing to kidney injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The discussion around value-added scores can be expanded to focus not just on replacement of teachers with low value-added scores, but also on the training and development of teachers. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We suggested that this shape of form abnormal was related to renin-oriented aldosterone hypersecretion, which could not be reckoned as Independent incretion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The interactions are necessary since the attributes of the object endow the word with part of its given meaning at the same time that the word is one of the numerous secondary (e.g. acquired rather than innate) associations of the object.The current results strengthen this separation of functional realms by emphasizing the selective impact of left temporal tip atrophy on the integrity of verbal rather than non-verbal representations of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In other words, Oxford House participants showed an overall increase in tolerance compared to usual care participants, but those men and women who lived in Oxford House for a longer period seemed to have had a greater chance of benefiting from the communal-living experience. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These properties are likely to favor image quality and, potentially, diagnostic accuracy, although this latter feature remains to be further assessed in dedicated ancillary studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings might indicate that prayer can be a useful factor in pain management but only for pain patients who are religious. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, improving and standardising the recording of patient risk factors and clinical symptoms in sample test-request forms would provide useful information on the burden, risks and acquisition of EV-D68. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical response was also shown to be influenced by serum antibody half-life, with values ranging from 127 to 3708\u200ahours following this standard infusion protocol39. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, from a geneticist\u2019s point of view, the contradiction between the present study and the initial observations [13] can be explained by the presence of linkage disequilibrium (LD). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The first season was unusual compared with subsequent ones in its timing and may have had a lower age distribution, the reasons for this are unclear but could be consistent with the arrival of emerging EV-D68 within Wales. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was particularly apparent in Patient 1 where peripheral B cells repopulated but without a change in disease activity and radiological features showing stable and, to some extent resolving, inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Information processing speed is also known to decline with age [Der and Deary 2006; Salthouse 1996], and low scores on the DSST have been associated with both incident mild cognitive impairment (MCI) and dementia [Lopez et al  2003a; Twamley et al  2006]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our initial sample size estimate is based on a rate of relapse of 40% in the placebo group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The negative association between availability to fruit and vegetable vendors and fasting glucose may have been a chance finding due to variability in fasting glucose levels or multiple statistical testing in our study, and needs to be confirmed in further studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicians managing such patients should consider establishing a prostate cancer multidisciplinary clinic if not already present at their institution. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The onset is neonatal, the disorder is normokalemic, the attacks selectively involve bulbar and respiratory muscles, physiologic rates of stimulation decrement the CMAP abnormally, and the muscle fiber membrane potential is normal when action potential generation fails. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relative to other published studies, (Romano, Bloom, & Syme, 1991) levels of stress, daily hassles, and lifestyle chaos were high in the sample. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding was expected as the GRS63 includes nearly four times as many genetic risk markers for BMD compared to the GRS16. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New tools such as RDTs for malaria and other infections have the potential to give para-professional providers a limited but important role in diagnosis and treatment algorithms. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, the tributaries of the CS were evaluated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, it is possible that more resilient patients have a higher QoL and are more likely to take medications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in a previous report, the sensitivity for identifying patients with coronary stenosis was found to be rather high (88%) for stress SPECT recorded with the biker position (15), and the rate of normal stress D.SPECT images reached 97% in patients with a less than 10% likelihood of coronary artery disease (normalcy rate), strengthening the general consideration of a rather low rate of artifacts with the biker position (15). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this Saudi sample, the mean arch widths were narrower when compared to a Turkish sample,19 a North American sample, a South American sample, a Korean sample,20 and an Egyptian sample;21 on the other hand, it was close to a Malay sample.22 These ethnic groups\u2019 differences in arch dimensions explain the need for specific orthodontic arch wire for each patient, based on the initial arch form. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That study showed a statistically signifi cantly better EQ-5D outcome (by 0.03) in favor of the PA group (Lindgren et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, many researchers have attempted to develop a prenatal, noninvasive, and rapid method of diagnosing intrauterine inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We carefully designed our subgroups for analysis a priori, and had sufficient data to accurately assign study subjects to subgroups with confidence, minimizing the likelihood of bias related to misclassification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first evaluation of the Xpert GBS assay in gastric fluids. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical significance of the slower transit in HLA-DQ2/8-positive patients is unclear, given the relatively small sample size and the multiplicity of transit end points, some of which (e.g., SB transit and ascending colon emptying time) were not different according to HLA-DQ status. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We suggest that, if possible, attempts to investigate additional phenotypes that may be associated with a variant should not use individuals that have been ascertained on the basis of the phenotype of interest; instead, they should be drawn from independent cohorts and selected solely on the basis of being a carrier of the variant under study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, significant osteomalacia can be present even with normal bone mineral density, serum calcium phosphate, and parathyroid hormone, and bone biopsy may be appropriate in some patients. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The novel result of our study was the association of eating competence with decreased risk of metabolic syndrome, as defined by the Joint Interim Statement criteria [32], and particularly, improved peripheral insulin sensitivity, as indicated by higher Matsuda ISI and lower fasting insulin in ECPs than in NECPs (Table 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we assume that the antimetastasis activity of ANP does not solely depend upon the suppression of E-selectin, because extravasation of cancer cells in the metastatic process is regulated by many other steps. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Zhao et al. reported that the AA allele of DICER1 rs3742330 is related to an increased CRC risk19, while Cho et al. determined that the DICER1 rs3742330 AG genotype leads to an increased risk of colon cancer but not rectal cancer66. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such a discrepancy is apparent in our results because 47% of staff who responded reported personal experience of pacemaker explosions at some point in their career, but only 41% of staff estimated no events occurring in general. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, experimental evidence has linked the deleterious effect of partial/complete airway obstructions, and accompanying hypoxemia and hypercapnia to the cardiovascular system through several processes, including activation of the sympathetic nervous system, endothelial dysfunction, inflammation, oxidative stress, vascular smooth muscle cell activation, platelet activation and thrombosis14. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longer follow-up is necessary to confirm this early favourable outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From the Sixth KYRBWS-VI data in 2010 in Korea, smoking rate of aged 12\u201318 was 16.6% in boys and 7.1% in girls [30]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased density of ready-to-eat food outlets and decreased distance to nearest ready-to-eat food outlet were associated with higher risk of type 2 diabetes in 347,551 UK Biobank adult participants (Sarkar et al, 2018). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another interesting aspect that should be considered for further investigations is the finding that certain metabolites strongly correlate with microbial community structures which would allow gaining insights into microbiome\u2013host interactions, also in context of certain diseases and therapeutic interventions [50,51]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are, however, some limitations that must be considered. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is the first step in researching factors influencing QoL in HIV patients in Georgia, and it highlights the need for future studies to further direct evidence-based action towards improving QoL in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future follow-up of our cohort will be important to assess whether the associations we observed persist later in life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It appears, therefore, that left anterior temporal lobe atrophy leads to an excessive blurring of intra-category compared with inter-category boundaries, but predominantly in selecting verbal associations of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, most barriers endorsed by our participants emphasized internal or cognitive factors including lack of motivation, lack of energy, not wanting to change habits, and feeling better when eating unhealthy food. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such a decline in BC associated with a chronic disease such as TB is not surprising considering the extent of pathological damage observed in individuals with advanced infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the identification of MeCP2, an MBD commonly associated with the SIN3 complex, strongly suggests the involvement of the latter. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides the strongest evidence to date that sustained, carefully planned, differentiated literacy instruction supported by technology and using the best assessments and research-based strategies available is more likely to be effective than what is typically seen in classrooms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our review, oral short acting and long acting opioids were used in 60.3% and 48.3% of patients respectively, while intravenous opioids were used via PCA or non-PCA in 58.9% and 93.4% of patients respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, while the functional association between the mitotic checkpoint and histologic grade has not been well studied, a study of invasive ductal breast carcinomas has shown that disregulation of components of the APC [19] is correlated with higher histologic grade in these tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Four other prospective studies (Helzlsouer et al, 1994; Toniolo et al, 1995; Berrino et al, 1996; Dorgan et al, 1996) have also reported an association between relatively high serum concentrations of oestradiol and increased risk of breast cancer, while two others have reported results that appear negative but that may be statistically compatible with ours (Wysowski et al, 1987; Garland et al, 1992). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the design of the study being cross-sectional in nature and conducted among non-diagnosed participants, limits the implications of the present research, it does however suggest that emotion dysregulation and dispositional mindfulness and social support may play a part to aggravate symptoms of social anxiety. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the sample sizes examined \u2013376 subjects for LUMA and 332 subjects for Illumina 450 K Methylation are fairly large datasets, allowing for sufficient power to detect significant methylation changes if present. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypothermia exposures of the pups in these studies, and the subsequent equilibration period, inevitably required maternal separation of the pups for periods of 60 minutes and above, and therewith closely resemble our stress paradigm. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HLA system is the most important region in the human genome related to infection, inflammation, autoimmunity, and transplantation medicine31. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the kittens had been adopted by an employee. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower than therapeutic doses of antidepressant drugs are frequently used in long-term treatment to overcome side effects that might jeopardize patient compliance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this study represents the largest examination of HCV screening of adults with SMI served within the public mental health system 4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study provides several novel findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The importance of these end points of cortisol feedback is that ACTH secretory-burst mass and pulsatile ACTH secretion denote amplitude control (35); basal ACTH secretion largely signifies constitutive ACTH release (citation); and ApEn quantifies ACTH secretory regularity, a validated barometer of feedback adaptations (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unfortunately, no WGS data are available for the Egyptian isolate to evaluate such a link. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This attitude may have indicated a tendency to use more proactive coping strategies and thus, use prayer as a positive coping technique. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This, in combination with a relatively small number of probes, contributed to the low P values estimated by our permutation testing (Table 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, continued rigorous research on effective instructional models is vitally needed to provide the cumulative benefits demonstrated in the present study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This understanding is essential to confronting the complex relationship between poverty and illness, and prioritizing interventions that address these two inseparable problems.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Barriers related to structural issues\u2014the least reported barriers to behavior change in our study\u2014have been the focus of rural health disparities research but such barriers appear to be only one of a series of challenges to behavioral change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Case 4 demonstrates the potency of a chronic negative calcium balance in stimulating the parathyroid glands, with the apparent development of an autonomous parathyroid adenoma in this patient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a similar interventions in managed care settings, Green, et al found a greater treatment effect in patients with baseline SBP \u2265160 mm Hg and Magid, et al found greater treatment effects in patients with diabetes or CKD but did not perform a statistical interaction test[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Korovessis et al. [18] have shown that the proximal bone mineral density measured immediately after operation around Zweymu\u00c8llerAlloclassic\u00d2-SL stem remained unchanged after 4 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, only genes implicated in mitotic entry or the mitotic checkpoint were suggestive of gene-level associations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two out of the 11 participants who received the minimum intervention dose were in the pre-contemplation stage; had these participants been excluded, the intervention would have been successful in 78% of participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that the best opportunity to reduce pre-hospital delays is during the period in which patients are seeking help outside the home, before the decision to escalate to the referral hospital is made. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This indicates that as the participants beliefs in personal need and concern regarding analgesics become stronger, they take a higher total weekly dose of analgesic. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breast cancer screening programs have been actively conducted in Turkey to national standards of Cancer Early Diagnosis, Screening and Education Centers, which were established under the Directorate of Public Health. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These mixed findings may relate to the complexity of measuring crime, which is likely to be sensitive to time of occurrence, location, people\u2019s perceptions, and social context [Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is predominantly related to a higher dropout rate than expected (see Figure). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The role of vitamin D deficiency in the metabolic bone disease of coeliac disease is also debated; it is not certain whether hypovitaminosis D contributes to the intestinal calcium malabsorption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a minimum, therefore, it is essential to include appropriate geographically-matched controls (as was the case in the original reports that are the subject of our replication study). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of 841 acetabular replacements with the same CLW component, Decoulx et al. reported annual cumulative rates of 88.3%, 90.9% and 87.4% respectively using hip pain, radiographic stability and revision as end points, for the smooth component versus 96.4%, 100% and 99.8%, respectively, for the grit-blasted [7]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study show that probability of developing atopic dermatitis was positively associated with increasing stress levels (very high, high, and moderate compared with none) only in boys. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The finding that treatment with demethylating agents is able to completely revert the binding of MeCP2 to the BIM locus (Figure 5F) suggests that BIM silencing could occur through the following steps: CpG methylation\u2192binding of MeCP2 to methylated CpGs\u2192recruitment of SIN3 core-pressor complex\u2192deacetylation of histone tails\u2192chromatin condensation (Figure 7). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, rs7574865 has been shown to influence the mRNA level of STAT4 in our published HBV-related HCC GWAS13. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, DNA damage is a possible cause of tumorigenesis69. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are several possible explanations for this. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reported disproportionate hyperinsulinaemia in carriers of these deletions is reminiscent of the phenotype of SH2B1 knockout mice [30], which previously led to the suggestion that haploinsufficiency of SH2B1 is the primary cause of obesity in these individuals [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the identification of new downstream targets of NFAT activation in podocytes is crucial to the development of new therapeutic strategies. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, non-poor adults may be prioritized, and encounter the fewest delays because their households are the most willing and able to pay. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Population incidence of confirmed cases in Wales is highest for children younger than five years, as is the number of ICU cases; however the risk for ICU admission appears higher in adults aged 65 years and older. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A scientific investigation on some patients undergoing oncologic treatment for breast cancer revealed that 84.8% of the patients noticed the disease themselves. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, D-dimer levels track the severity of disease progression and inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor follow-up has been cited as a major problem in many community screening projects 7,8. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low oxygen concentration significantly improves the developmental potential of pre-compaction stage embryos, resulting in a positive effect on subsequent blastocyst cultivation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings not only reinforce the superior sensitivity of diffusion tensor MRI for detection of subtle changes in brain white matter but also highlight the significant correlations between early white matter development and later outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is evidence from longitudinal studies that integrated development interventions have already had a positive impact on health seeking as well as health outcomes elsewhere in Bangladesh [49, 50]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "B cells also appear to play an important role in GPA granuloma pathogenesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrated the induction of cellular death in RTCs incubated with CRS Type 5 plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, rs7574865, which was located in the third intron of STAT4, was significantly associated with the risk of progression to LCs in patients with CHB. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the first time, we have identified elevated PWVcf, increased intima-media and adventitia echodensity, abnormal ABI, and increased ICA mean flow velocity as pervasive disease features in HGPS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Naming errors fit this classification only if the unnamed object as well as the word denoting the object had been accurately defined and also if the two had been accurately matched to each other on two separate pointing tasks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nunez et al studied the effects of exposing newborn Hooded rat pups to 5\u00b0C and measured a significant decrease in occipital cortical thickness, predominantly with 30-60 minutes of cold exposure; these effects were more pronounced in male compared to female rats. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show that a substantial number of anomic errors for relatively common objects in patients with predominantly left temporal tip atrophy can actually arise from pure lexical retrieval impairments despite the preservation of the relevant word and object knowledge. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether we should take an aggressive approach to meta-static disease simply because it is available and whether this approach actually helps patients still needs addressing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The interval from first seeking help to the household\u2019s decision to escalate care to the referral hospital was longer for adults from poor households compared to non-poor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Noninvasive diagnostic tools used to assess the risk of HCA include measurement of maternal serum CRP levels and leukocyte counts, but these conventional infection markers, when used alone, have poor diagnostic value in distinguishing patients with HCA from those with no placental inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We show here, that a relatively short, combined psychosocial/physical stress protocol in neonatal Balb/CByJ mice, results in increased corticosterone levels during the stress hypo-responsive period (Sapolsky & Meaney 1986) and leads to significant changes in somatosensory cortical size and architecture in Balb/CByJ mice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The two gene pairs we identified for use in predicting which patients will develop distant metastases of prostate cancer after undergoing RRP were TPD52L2/SQLE and CEACAM1/BRCA1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, attention should be paid to negative re-appraisal aspects of prayer as well. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comprehensive studies are needed to advance our understanding of the relationship between the blood and genital compartments among those both on and off ART, as well as specific factors within the genital tract that drive seminal plasma HIV-1 RNA levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present phenotype differs from that of periodic paralyses associated with hitherto identified mutations of SCN4A. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that the genetic influence on BMD change is different from that on peak BMD, highlighting the need for well-powered GWAS meta-analyses on BMD change to identify genetic risk markers related to bone loss. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have investigated the population structure of ST131 with WGS data and found a sublineage, C/H30, defined by the presence of the fimH30 allele. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased spine densities, in were observed under all separation conditions in layers II/III, but were most pronounced following separation on PND 5-7 when significantly increased volume in basal dendrites also was seen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An assessment of depression, anxiety, and coping using specific and objective tools would be helpful to correlate our findings with these measures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mobile colistin resistance gene mcr-1 has been reported in ESBL-producing E. coli ST410 in Brazil (24) and Germany (25) but was not observed in our 127 isolates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An almost 10% lower tomographic count sensitivity was documented in the present study for the biker position than for the supine position. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed significantly increased in vitro levels of apoptosis and necrosis in RTCs incubated with plasma from CRS Type 5 patients compared to controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Now few laboratories have attempted to compare the difference among primary aldosteronism, chronic primary kidney disease and essential hypertension. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that, as in prior studies, (Solomon, et al, 2005) short-term process outcomes (e.g. speaking with a cessation counselor) do not translate into longer-term sustained smoking cessation outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite confounding effects by factors such as gestational age at birth, these correlations remain significant in many brain white matter regions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since BMD is sometimes known, it is crucial to also evaluate the clinical utility of GRS63 for fracture discrimination and reclassification in a BMD-adjusted base model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This technique may offer anesthesiologists prospects for establishing a better, direct assessment of the patient\u2013ventilator interaction and a more protective mechanical ventilation protocol.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "How might patient navigation be effective in linking patients to treatment? ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AKT is key target molecule in the downstream of phosphoinositide 3 kinase and activated AKT is involved in a series of biological progresses, such as cell survival, growth and proliferation[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, at first glance, increases in spine and dendritic volume in the Bock et al study appears to be in conflict with the thickness decreases we observed in layer II/III in our STR-B mice, and certainly the opposite as seen by Gibbs and Kolb. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent in vitro studies have demonstrated that gliadin interacts with the chemokine receptor CXCR3, leading to increased zonulin release and increased intestinal permeability (21), possibly through activation of the innate or adaptive immune system, leading to an inflammatory response (11). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it is difficult to achieve complete pain control, and consensus about treatment options and dose titration is lacking (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The brightness of an image is determined by the number of returning echos, which is proportional to the density of the tissue being evaluated.21 We found that the intima-media complex in HGPS is of normal thickness, but abnormal echodensity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While all other components of MPI can be ascertained based on household characteristics preceding the illness, nutrition status of the household must be measured at the time of interview, and could potentially be affected by rapid weight loss as a consequence of AFI. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ratio of cartilaginous to membranous vocal fold in the rat is 2:1 (whereas this ratio in human is 1:2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Median LOS was 5 days, and it was generally shorter than the results presented by other authors [34\u201337]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive predictive value of a positive screen also varies widely by age. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison, Patient 3 demonstrated significant PR3-ANCA antibody production without evidence of peripheral B cell repopulation, which emphasizes the need to consider granulomata in GPA as B cell containing tertiary lymphoid structures pivotal to driving the relapsing disease course. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential public health and clinical implications of our findings are worth noting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We cannot rule out the possibility of type-II error in our study, if the MCID is less than 10 points as we used. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach depends only on administered dose and CL and provides an integrated assessment of drug exposure rather than relying on a single point estimate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For now, a definition based on up to five detectable lesions is widely employed and is reasonable for use. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, this study demonstrates that a reduced margin of safety for neuromuscular transmission may occur in the setting of a normal EPP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early reports proposed the use of IBW based on desirable weight for height tables; however, the limitations of this approach in patients with obesity led to the consideration of \u201cobesity-adjusted\u201d scalars, such as adjBW, DBW, and LBW (4, 5, 9). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, future research may examine how changes in tolerance may be related to participants' own perceptions of stigma in regards to their addictions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The low incidence of serious PPCs in both groups can be associated with rapid postoperative rehabilitation and decreased perioperative morbidity and mortality in patients undergoing laparoscopic abdominal surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A negative serologic test result may therefore be helpful in excluding C. trachomatis infection, given that enough time has elapsed since the time of exposure for an antibody response to develop. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pacemaker explosions are potentially costly for the crematorium owner and may lead to legal proceedings against funeral directors, physicians and health authorities to recover losses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Plasma concentrations of clusterin have been reported to be associated with atrophy of the entorhinal cortex and more rapid global cognitive decline in AD patients [Thambisetty et al  2010], and were also negatively correlated with global cognitive function and with attention-processing speed as measured by the DSST in 664 participants in the Sydney Memory and Aging Study (mean age 78 years) [Song et al  2012]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future interventions must consider incorporating multiple levels of influences to address these deeply embedded barriers that cannot be addressed by cognitive, social, and ecological strategies alone. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with previous studies, the scales on which the highest proportions of individuals scored in the clinical range were Masculinity/Femininity and Psychopathic Deviate3,5,28,31,36,37. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were several limitations to our present study of note. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Schedule B was slightly less conservative, as the maintenance dose was reached in the first visit by 30 min, separated by administration of 0\u00b72 and 0\u00b73 ml of the maximum concentration vial. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, there is no routine collection of data on explosions in UK crematoria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive effect on blood pH and serum bicarbonate levels is evident in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over half of ETC + navigation participants did not receive the minimum intervention dose. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, we had limited information on other factors that can influence genital tract inflammation, such as CMV serostatus 14,18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Twelve months after ventro-dorsal spondylodesis, one patient developed reactivation of the infection in the same segment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Humans have longer pharyngeal \u2018dwell\u2019 times before triggering of a pharyngeal swallow and oral residue during larger bolus presentations or continuous eating and drinking [67, 70]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the present study found that regardless of educational, socioeconomic or demographic status, having a high incidence of breast cancer in the family plays the greatest role in determining whether an individual practicies BSE. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An increasing prevalence of diabetes mellitus (DM) has been reported in patients with primary aldosteronism (PA), and they suggested that diabetic dyslipidemia and modification of circulating lipoproteins should promote adrenocortical aldosterone synthesis [33]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Again this is not suitable for patients undergoing an emergency procedure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The traditional univariate analysis detected significant association with fourteen risk factors while the Lasso logistic regression produced a sparser model with eight risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epigenetic silencing can be triggered by CpG methylation through two main mechanisms: DNA methylation can repress transcription by directly impairing the binding of transcriptional activators to cognate DNA sequences [47,48] or MBP can bind to methylated DNA sequences, thus recruiting multi-protein corepressor complexes carrying HDAC activity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on previous research in a group of 10 patients with TBI, which reported condition 6 of the SOT to be significantly associated with the physical component of their DHI,17 we expected vestibular integration to be a significant predictor in our analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In previous studies, the proportion of ECPs has varied between 18% and 53% [6,7,9,10,12,14,33]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than two-thirds do not meet the Australian recommendations for moderate-intensity physical activity, and nearly 80% do not meet recommendations for vigorous-intensity activity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obviously, at this time, patients were not fully integrated into normal life, and an accurate assessment of general state of health and pain is not possible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have not seen breakage of a ceramic head or separation between the polyethylene liner and the metal backing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the epigenetic silencing of BIM may play a crucial role in protecting ALCL cells from apoptosis, other mechanisms leading to the down-regulation of BIM have previously been identified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One liability of the current study is the lack of biological validation of self-reports. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Too little, too late? ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is, however, considerable interindividual heterogeneity in the location of initial peak atrophy sites and the trajectory of progression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, enhanced surveillances and/or follow-up studies on EV-D68 cases are needed to better understand the risks, duration of illness, length of hospital stay, patient outcomes and long-term sequelae. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the results from this study should be interpreted carefully. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high intake of lutein/zeaxanthin was inversely associated with CRC risk in G allele carriers (AG\u2009+\u2009GG) compared with that in AA homozygous DICER1 rs3742330 carriers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The absence of category specificity in the current study may thus reflect the paucity of major peak atrophy sites in these basomedial parts of the temporal lobe. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although participants were satisfied with the program and had low rates of attrition, this inward focus may have unwittingly undermined its success. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the Shuar, immune-related tradeoffs appear to explain much of the \u223c1-cm/y growth rate deficit that children face relative to international standards (27) as well as the modest secular increase in stature accompanying economic development (63). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may reflect higher utilization of qualified private doctors by non-poor adults, compared to poor adults and children, who were more likely to consult unqualified practitioners. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both raw and roasted almonds showed potential prebiotic effects on intestinal bacteria and metabolic activities, showing a stimulatory effect on fecal Lactobacillus spp., and Bifidobacterium spp. [40]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the coroner's certificate now accounting for about a third of disposals16, it may be that some pacemakers remain in situ. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, high lutein/zeaxanthin intake was strongly inversely associated with reduced CRC risk in all anatomic subsites, including the proximal and distal colon and rectum. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Associative anomias and interpretation of object knowledge Naming errors were considered associative if the picture of the unnamed object or the word that represented its name could not be defined verbally, or if the two could not be matched accurately in at least one of two pointing tasks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Kr\u00f6del and others [9] have described the possible failure of ventral fixation in patients with an osteoporotic bone structure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although this study shows that gender differences exist with regard to social anxiety with girls reporting higher symptoms, further studies and integration of findings with existing theories is necessary to enhance the understanding of gender differences in social anxiety, thus facilitating gender-sensitive and specifically-tailored policy implementation for both boys and girls with social anxiety. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study revealed that HIV-infected persons with a CD4 cell count \u2265200 cells/mm3 are more likely to have better general QoL as compared to those with a CD4 cell count <200 cells/mm3, after adjusting for other predictors of QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore compared with other studies investigating CIN in ICU patients, our overall incidence is low 37. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may also be related to the small sample size or with the fact that these two subscales were obtained from questionnaires instead of direct observations by trained psychological examiners. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many changes in the management of pain can be observed over the time period that this review covers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For ethical reasons, we did not include a control group without the administration of theophylline. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taking into account the religious affiliation of the pain patient, a more detailed picture appeared. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has several limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we observed the influence of the time interval between prior cervical conization and posterior hysterectomy on postoperative infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Echobrightness on ultrasound increases as tissue density increases; each pixel represents one returning echo at a particular depth where the ultrasound encounters tissue. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "OIH and acute opioid tolerance have been well established through multiple animal studies,7,10\u201312 although their relevance to humans and the exact underlying mechanisms are still unclear6\u20138,13,15\u201319. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, cardiovascular risk factors such as hypertension and obesity generally develop and track over a long period of time (Mancia et al, 1993). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No angiogenin was released by unstimulated monocytes or by LPS- or MDP- stimulated monocytes (< 200 pg/ml), whereas the cytokines IL-1\u03b2 and TNF-\u03b1 were readily expressed by these cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also found that the level of CEAs had a significant effect on the survival of CRC patients with liver metastasis (HR = 3.056; 95% CI = 1.354\u20136.897; P = 0.007). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The only structural brain abnormality common to all 11 patients in this study was the exclusive or predominant location of peak atrophy within the left anterior temporal cortex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of our study warrant further determinations and more detailed mechanistic investigation of inflammatory mechanisms in CRS Type 5 patients that may contribute to gradual toxic injury in renal cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TPD52 reportedly regulates the migration of prostate tumor cells.20 SQLE is a gene from the 8q24 region that has been strongly associated with prostate cancer risk in several genome-wide association studies 21\u201323. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A previous experiment, based on event-related potentials elicited by our Graded Object Association Task, offered an alternative demonstration of this phenomenon with a paradigm that required no verbal responses (Hurley et al, 2012). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For this study we carefully classified patients as having CKD by repeated measures of estimated glomerular filtration rates and urine albumin levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this association may not be directly causal, instead it might be an indirect consequence of testosterone acting as a precursor to oestradiol or may be as a result of the strong correlation between the two hormones; our results suggest that oestradiol is independently associated with breast cancer risk but testosterone is not. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Classifying such individuals as being negative for TB would not only underestimate the effect of TB on survival in infected animals, but also lead to lower survival probabilities for apparently uninfected individuals that were actually infected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This apparent paradox could be explained by LUMA\u2019s characteristics, i.e. broad coverage in CpG dense regions, such as promoters, and decreased coverage in the remaining genome [27]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, increasing evidence emerges that severe COVID-19 is a multiorgan disease associated with a coagulopathic state 27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These complex processes are referred to as thrombo-inflammation or immunothrombosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, in the biker position, the anterior chest wall directly leans on the surface of the camera head. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several limitations of this study should be considered. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, there was no standardized postoperative pain management at the postanesthetic care unit or ward. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An integrated effort toward encouraging walking, cycling, and public transport use, while reducing dependency on cars, is a promising strategy to significantly increase active commuting, and therefore, physical activity in LMICs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, 30\u201350% of women in the premenstrual phase experience an exacerbation of atopic dermatitis symptoms, and the ovulatory phase aggravates the condition of atopic dermatitis [36]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While we used a pediatric ultrasound transducer with the highest available frequency, the relative lack of subcutaneous neck tissue5 precluded adequate image resolution along the carotid arterial near wall in many cases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the large majority of our participants had no phone contact with study staff during the study, thereby decreasing experimenter demand. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Five persons mentioned having seen a hay lorry in the docks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, these findings suggest a local role for angiogenin in joints exhibiting inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current study shows that eating competence is associated with a better quality of diet, a lower prevalence of new type 2 diabetes, abdominal obesity and metabolic syndrome, as well as better insulin sensitivity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We hope this work stimulates the development of portable insoles that can be tested for their effect on falls in large elderly populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We are aware that a few patients may have guessed their intervention. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, they did not believe the benefits of BSE and made excuses not to examine themselves. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the contrary, the Xpert GBS assay showed performance characteristics similar to those for culture but gave a more rapid result, with results in less than 1 h versus requiring at least 1 day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our series, amitriptyline was used in 12.6 % of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study indicates that variation in white matter microstructural integrity in healthy newborns correlates with neurodevelopmental outcomes at age 2 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, due to the single population and small sample size, the results need to be confirmed in the future with well-design and large samples.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Notably, the decreased risk of metabolic syndrome in ECPs was independent of BMI as the association was significant even after adjustment for BMI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In two reports, E2 addback in postmenopausal women, compared with no addback, blunted the cortisol response to a combined dexamethasone suppression/CRH stimulation test, implying greater ACTH suppression (14, 16). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be that working age patients have less access to clinic-based care due to work obligations and time constraints, and that the telephonic nature of pharmacist care provided more regular access to care including needed medication adjustments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although careful experimental design and the inclusion of additional phenotypic and/or experimental data can help to limit this problem, our findings illustrate the urgent need for well-defined, robust statistical methods that are readily applicable to the search for causal, rare, genomic structural variants.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A large amount of inflammatory mediators were circulating in the body. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We therefore performed hysterectomy after prior cervical conization for older patients with high-grade CIN (grade III) or early cervical cancer (IA1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although transaminase increases were common with trabectedin, they followed a predictable pattern with a peak elevation at days 5\u20137 and a return to grade \u22641 at approximately day 15 of each cycle, and with a clear trend towards reduction with subsequent cycles (Fig. 4)10,17. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Echodensity is an emerging area of study in cardiology and aging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although some studies have concluded that the MMPI profiles of the participants indicated serious psychological disturbances, depression, and interpersonal problems12,26,27,28,29, others have concluded the opposite3,5,7,8,30,31,32,33,34,35. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CDI measures blood gas parameters at the actual temperature and converts them to 37\u00b0C values to be displayed on the screen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, no difference in plasma angiogenin levels was found between patients with inflammatory joint disease and those with OA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, it is conceivable that our results cannot be generalized to patients with gluten intolerance by history or response to gluten withdrawal; these patients might be more likely to recognize gluten as an antigen that leads to increased inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our finding of a positive correlation between IL-17 and HIV-1 RNA levels in seminal plasma directs further attention to the potential role of Th17 cells and/or NK cells in driving inflammation that increases HIV-1 RNA levels 23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More surprisingly, LOS deficits were more prevalent than sensory organization problems in our cohort (Fig. 1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After stratifying the study population in subjects vaccinated in infancy or adolescence, a significant difference in the proportion of seroprotected subjects emerged: a higher prevalence of seroprotected have been registered among those vaccinated in adolescence (81.9% vs 66.9%, p < 0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike fresh food which can be grown/produced, the highly processed and take-away food can generally be purchased through vendors only, which could limit the differences in findings between countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison, the time to the most recent common ancestor for the ST131 clade was estimated as the late 1800s (22). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In any case, the results highlight the importance of enhancing ARV treatment and adherence programs. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another component of the model here is using the cached values for unexpanded parts of the model, which is in line with previous works [11, 12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the present study further indicated that compared with other time intervals, hysterectomy within 2 weeks after conization led to higher post-hysterectomy infection rates, increased severity of infection, higher grade and prolonged use of antibiotics, increased inflammatory cell infiltration, delayed postoperative recovery, and extended hospitalization time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The gene expression profile of embryos cultured in 5% oxygen more closely approximated that of embryos that developed in vivo when compared with those that developed in 20% oxygen concentration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In India, much remains to be done to measure, adapt, and design built environments to promote active commuting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We did not find a strong correlation between the occurrence of fracture and low bone mineral density in this survey, and this suggests that\u2014as in the general population\u2014other determinants of fracture risk such as the incidence of trauma and bone quality may be additional predisposing factors in coeliac disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A consensus conference sponsored in 1996 by the US National Depressive and Manic Depressive Association concluded that fewer than 10% of patients with unipolar major depression receive adequate antidepressant treatment as regards dosage and duration (Hirschfeld, Keller, Panico, Arons, Barlow, Davidoff, Endicott, Froom, Goldstein, Gorman, Marek, Maurer, Meyer, Phillips, Ross, Schwenk, Sharfstein, Thase and Wyatt, 1997). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study also included several measures of BMI in the first 2 years, providing greater granularity in estimating BMIz trajectories, as well as several measures of adiposity at age 5 years, including WHtR, skinfolds and fat mass. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, we suggest that the frequency of acute inflammation during early life serves as an honest signal of environmental pathogenicity and, thus, future immunological energy demands. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These inconsistencies are mostly due to inter-laboratory differences, but also in intra-laboratory variation, including culture media composition, stimulation regimes and laboratory protocols. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed a J-shaped relationship between sleep duration and total stroke risk, after controlling for potential confounders in the southern Chinese population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The identification of prognostic factors is the critical for improving the survival of CRC patients with synchronous liver metastasis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cellular death may be activated by proinflammatory cytokines, and apoptotic signals may be triggered by different types of receptors, amplified downstream and converged, probably, in activation of NFkB. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is consistent with empirical evidence from the \u201cStrength Model\u201d of motivation (Hagger, Wood, & Stiff, 2010) and the concept of \u201ccessation fatigue\u201d (Liu, Li, Lanza, Vasilenko, & Piper, 2013), both of which posit individuals have a finite amount of \u201cenergy\u201d for self-regulation and predict that repeated failures should result in less motivation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Theophylline and sodium bicarbonate interact with different mechanisms in the pathophysiology of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The administration of theophylline in combination with bicarbonate hydration reduces the risk of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated levels of interleukin-6 (IL-6), CRP, erythrocyte sedimentation rate, and fibrinogen indicate systemic inflammation in patients with COVID-19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is reasonable for IVF clinics to use low oxygen concentration from embryo cul ture beginning, and it will optimize the patients\u2019 treatment outcome in a long-term perspective. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In that case, the algorithm could increase the efficiency of the state-of-the-art algorithms that use a plan-until-heuristic scheme in complex games [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, RTCs apoptosis and necrosis were observed in CRS Type 1 both in human and in animal kidney during AKI [19, 20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The full mediational effect indicates that prayer is not related to pain tolerance directly, but that the psychological/cognitive process alters the impact of pain on daily life activities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent studies have shown that an inflammatory process plays a part in the pathogenesis of osteoarthritis [13,14]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, several reports have found no clinical evidence of acute opioid tolerance after intraoperative infusion of remifentanil. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For hip fracture the association and reclassification capability of the GRS63 was stronger compared to that of GRS16. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When investigated with this approach, patients with semantic PPA displayed a significant N400 potential in response to the unrelated mismatch but not in response to the related one. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, in one patient with gouty arthritis, SF angiogenin levels decreased with the resolution of acute inflammation, suggesting that this molecule may either reflect or play a role in monosodium urate crystal-induced inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A PEEP of 10\u200acm H2O proved sufficient for reversing the ventilation distribution changes resulting from general anesthesia, yet was too low to prevent the adverse effects of pneumoperitoneum 23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effort needed to learn how to operate the Plusoptix photoscreener was moderate and the photoscreener was highly portable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the majority of transplants from the trial selected the best available KIR donor for transplantation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although this requires further studies, we are convinced that ERAS perioperative care guarantees non-inferiority. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the disease develops, we spontaneously believed that it was secondary changes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous authors have noted that the Masculinity/Femininity scale refers to stereotypical male and female interests and most likely reflects gender dysphoria25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main findings of this study are as follows: EIT-guided mechanical ventilation resulted in better ventilation distribution and oxygenation in patients undergoing laparoscopic abdominal surgery; and a FiO2 of 3 was sufficient to maintain the intraoperative balance between oxygen supply and consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus in the situation when BMD is unknown, the GRS63 adds statistically significant, but minor information, to fracture discrimination and reclassification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anxiety thoughts including social anxiety do affect girls more than boys; they have more metacognitive beliefs about uncontrollability of worry and believe that worry must be avoided [25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another possibility is some residual confounding by age despite adjustment, since younger patients are more likely to have elevated DBP. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to present study, Only a small proportion of patients (between 9 and 37%) were hypokalemia [30]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is worth mentioning, that decreases in cortical thickness have previously been reported following cryo-anesthesia in newborn rats (Kolb & Cioe, 2001; Nunez, Kim, & Juraska, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Present results simultaneously inform interlinked agendas, including spatial growth management, effective land use, formulation of transport policies to ease traffic congestion, vision zero initiatives, and clean air policies, with the potential to establish and extend the field of active living research in India [82].", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, any negative effect of TB on field vole survival is likely to have been under-estimated, due to individuals dying before being caught with overt cutaneous symptoms and being recorded as negative in the survival analyses, and due to individuals only caught once with TB lesions not being included in the analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found a between-group difference in general health status (EQ-5D-3L) of \u22120.04 (95% CI: \u22120.1 to 0.03). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our analyses, short commuting distance from home to work demonstrated a strong association with active commuting in unadjusted models, which confirms previous research [58], but it did not remain significant in adjusted models. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GBS detection is a microbiological emergency and is conducted 24 hours a day in several places that rely on microscopic examination. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis of proteins and nitric oxide (NO). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A possible reason is the more invasive procedure involving two operations on the spinal column in the patients of group 1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If this were done, we would have an accurate record of the frequency and consequences of explosions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improper specimen collection for direct specimen testing, such as collection of specimens with suboptimal cellular material, is one possibility. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the period after the start of bypass is often characterized by an unsteady blood flow return, resulting in unsteady blood and gas flows for a period, which is not always foreseeable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The putative mechanisms whereby increased permeability and reduced TJ expression might mediate IBS-D symptoms are increased water flux, resulting in looser-consistency bowel movements, and visceral hypersensitivity, as demonstrated by Bertiaux-Vanda\u00eble et al. (3), who observed association of lower occluding expression with more severe abdominal pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The goal of ARR is to provide a balance between missing clinically cancer and performing unnecessary adrenal venos sampling (AVS) in primary aldosteronism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These controversial results concerning the postoperative pain intensity and opioid requirement between laparoscopic surgery and robotic surgery may partly be explained by differences in the targets of operation (urologic vs gynecologic), criteria of opioid administration, and surgeon's experiences. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, a higher percentage of intervention participants had engaged in smoking cessation treatment by three months after study entry relative to control participants when the minimum navigation intervention was achieved (70% vs. 43%) \u2013 a difference which is clinically, although not statistically, significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In other clinical studies, obese premenopausal women exhibited greater percentage inhibition of ACTH and cortisol concentrations compared with obese men during low-dose (1 mg) dexamethasone suppression (23). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect is not only shortening of the LOS but also a significant reduction of postoperative complications without an increase in readmissions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A subsequent sampling of two patients resulted in the detection of two ST410 isolates in both samples, the first patient with 11 SNP differences between the genomes of isolates collected 13 months apart and the second patient with three SNP differences between the genomes of isolates collected 5 months apart. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We previously showed that ANP prevents the incidence of postoperative complications after lung cancer surgery (10\u201312). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although MCP-1 \u22122518 A/G has been the most commonly investigated MCP-1 SNP, there are other SNPs located in the MCP-1 gene [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In accordance with current European and American guidance (Center for Drug Evaluation and Research, 1978; Committee for Proprietary Medical Products, 2002), the use of relapse and recurrence rates as primary outcome measures in continuation treatment and long-term trials is recommended, albeit without providing an operational definition of relapse and recurrence with respect to psychiatric scales or other diagnostic criteria. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Theophylline inhibits renal vasoconstriction thus increasing renal oxygen supply. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, as policymakers place more emphasis on the effectiveness of individual teachers and the longterm benefits of effective teaching (Chetty et al., 2012; Konstantopoulos & Chung, 2011), it is clear that what teachers do in the classroom, their use of evidence-based instruction, their ability to differentiate this instruction, and the training and professional development they receive all make a difference in student learning and, hence, in teachers\u2019 value-added scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, inclusion of a morphomic estimate of skeletal muscle area to the Cockcroft-Gault scaffold [(140 \u2212 age)/SCr], as a replacement covariate for weight and sex, nearly doubled the amount of variability explained by the model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since cognitive function was assessed in the ARIC study in midlife in individuals without dementia, it is possible that the relationship between the MS4A4E SNP and AD, and the polymorphism and cognitive change may actually be different. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since 2014, the ERAS protocol has been a mainstay of perioperative care in our center regardless of the type of surgery performed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, generalizing the null results of our study in an middle-aged and older Chinese population to other populations is cautioned, since subjects with middle-age and older have been shown to have more opportunities in taking daytime napping26. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the duration of the intervention was short and the navigator worked part-time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If the lost neurons had contained this type of repository, and if it the term \u2018amodal\u2019 is interpreted to designate a domain-independent integration of semantic information, non-verbal and verbal object representations would have been expected to display comparable impairments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study results show that the risk of having atopic dermatitis and severe condition increased with higher maternal educational levels in girls and with higher paternal educational levels in both boys and girls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, ancillary moderation analyses showed that the relationship between prayer and pain severity as well as between prayer and pain tolerance is depending on the religiosity of the pain patient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, several studies reported that lutein/zeaxanthin intake was not associated with CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The concept has been articulated most succinctly in the following words: \u2018\u2026 the neural network for semantic memory requires a single convergence zone or hub that supports the interactive activation of representations in all modalities, for all semantic categories \u2026 damage to the hub should produce a semantic impairment that is independent of the modality of input (objects, pictures, words, sounds, tastes and so on) and of the modality of output (for example, naming an object, drawing it or using it correctly)\u2019 (Patterson et al, 2007). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result implies that big cities may have more sources of pollution that stimulate the autoimmune system [39]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study shows how much crematoria staff rely on accurate and complete cremation forms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because the physiological immune response of circulating leukocytes to systemic inflammation is accompanied by increased neutrophils and decreased lymphocytes, the NLR has been proposed as a simple parameter of systemic inflammation and stress in various diseases [13]\u2013[15]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis neither supports nor invalidates the use of neuropsychological tests in TBI, but rather reflects the failure of progesterone to improve outcome in this cohort of subjects with moderate to severe TBI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although inflammation existed around the cervix after conization, it has been reported that radical hysterectomy could be performed at any time after conization [15], which might be due to the excision of inflammatory organization around the cervix in radical hysterectomy, indicating that greater post-hysterectomy infection was affected by the inflammatory organization around the cervix. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because most public mental health care systems are not integrated with general medical care, future research could examine HCV screening and prevalence among people with SMI within an electronically integrated health care system that includes all laboratory tests and results (e.g., Kaiser Permanente). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Osteomalacia may occur without clinical or biochemical abnormalities and in the absence of steatorrhoea. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both the aging and 6-OHDA parkinsonian rat models manifested changes to the orophargyngeal swallow and these changes were identified by videofluorography. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, the results of this study appear to support the role of sleep habits as a fundamental determinant of the elevated risk of stroke in southern China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, the assessment of prenatal predictors of BMIz trajectories may enhance our understanding of etiologic pathways of cardio-metabolic disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More work is needed to establish the optimal \u201cpass\u201d and \u201crefer\u201d criteria ideal for use in Hawai\u2018i's pre-school children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, using measures that reflect parameters that are typical of rat bolus procurement and swallowing, we discovered that both aged and parkinsonian rats display oral and pharyngeal deficits and thus present a good model for use in studies aimed at uncovering biological correlates of dysphagia in these disease/disorder groups. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Lasso logistic model has been used in variable selection in many fields as it can effectively exclude some irrelevant variables and produce sparse estimations and good asymptotic properties34, but this study was the first to apply Lasso in the identification of the most important risk factors that contribute to elevated stroke risk in a case-control design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results might be attributed to differences in the range of lutein/zeaxanthin intake, CRC status and the point that CRC examination began in the cohort study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another limitation of our study is the absence of biomarkers other than serum creatinine in order to detect CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the United States (U.S.), two studies of university students indicated that the farther the distance or the longer the commuting times between home and university, the lower the likelihood was of choosing to use an active commuting mode [63,64]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patient P9 could possibly be linked to this outbreak via hospital H. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To better understand the contribution of mitotic genes to cancer predisposition we investigated whether inherited genetic variation in mitotic genes contributes to the development of breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In cases of severe renal insufficiency, unfractionated heparin should be administered. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, non-invasive measures including PWVcf, carotid wall echodensity and ICA flow velocity offer quantitative insights into accelerated vasculopathy in HGPS, and may provide sensitive indicators of disease progression or remission with adjuvant therapies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reports of the success of preemptive gabapentin treatment have been mixed (Adam, Menigaux, Sessler, & Chauvin, 2006; Dahl, Mathiesen, & Moiniche, 2004), and further studies are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While meta-analyses have suggested that breastfeeding is associated with a reduced risk of childhood overweight and obesity, this evidence is largely based on observational studies; reverse causality and residual confounding by behavioral or socio-economic attributes may explain the results of those studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results also converge with a growing body of research on the physiological processes of inflammation that call in question previous formulations of energy balance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since CPB gas and blood flow conditions are often very unstable for an unknown length of time after the start of bypass, during which period it is not possible to calibrate the CDI with a reliable result, we recommend gas calibration of the CDI 500 prior to use. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, the GRS63 was clearly associated with cross sectional BMD, but not with BMD change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While small numbers of patients enrolled in this pilot study preclude definitive conclusions, there is evidence to suggest that patient navigation may be an effective intervention. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Albeit imperfect, an appropriate animal model can provide critical insights into putative mechanisms underlying health and disease in humans, and is in fact, one of the only ways to do so. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Levels of plasma D-dimers should be determined in symptomatic patients with confirmed SARS-CoV-2 infection. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings seem to support our hypotheses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this article, AKT1 rs1130214, rs2494732, rs3803300 polymorphisms were analyzed the association with the onset risk of CHD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant clinical improvement was delayed and took up to 2 years for complete radiological resolution of the nodules in some patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our cohort, HIV-1 RNA levels in blood plasma were approximately 30-fold higher than in seminal plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The safety of both regimens was ascertained, as no local reaction over 0\u00b75 cm nor systemic reactions were registered after 650 administered doses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be some level of stress as consequence of the nest disruption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is now substantial experience with vision screening utilizing a photoscreener nationally and internationally including large screening programs of preschool children numbering in the hundreds of thousands.7\u201311 Experiences specifically with Plusoptix have also been published 12\u201316. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At St. Jude, physical rehabilitation may require as long as 6 months, even in the absence of postoperative complications or re-interventions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These genotyping goals were not met during the study despite repeated search method education sessions and encouragement throughout the trial period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The disease-specific inclusion criteria define a population of mildly to moderately depressed patients and thus reflect the clinical group in which Hypericum extract is predominantly used and in which most of the trials investigating the drug\u2019s efficacy in acute treatment have been performed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(K. Lasser, et al, 2011) While Lubetkin et al (Lubetkin, Lu, Krebs, Yeung, & Ostroff, 2010) have shown that PCPs serving low-income, racial and ethnic minority patients are interested in providing tobacco-related patient navigation services at their practices, we are unaware of prior studies that have examined the acceptability and feasibility of patient navigation for smoking cessation in practice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This comparison showed higher scores among the non-eligible individuals for two clinical scales: Hysteria and Schizophrenia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since 1995 there have been sustained and systematic efforts to improve control of BP and other major risk factors in adults with diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since aneuploidy and chromosomal instability are commonly observed in human cancers, further investigation of the influence of inherited variation in mitotic genes on tumor grade and cancer risk in additional studies of both breast cancer and other cancer types is merited.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither of our study groups was superior in terms of complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reliability and validity of the questionnaire data were assessed by previous studies [31], [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the approach allows only suggestive conclusions of whether or not the intervention was effective or not within each subgroup (\u201cabsolute effectiveness\u201d). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As shown by Maskell and coworkers,34 dizziness, along with anxiety and depression, commonly has a profound impact on quality of life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In vivo, the response of these cells could be partially different because of the presence of multiple different cell types, cell-cell interactions, extracellular matrix interactions, and the physiological context. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limitation of our study was possible interaction with other polymorphism may affect our results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The same study also showed that, although the primary complaint of 68% of the patients was the mass in their breasts, only 29.7% of them were performing BSE regularly (Bayer., 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TLRs 2\u20135, 7, 9 and 10 are expressed in melanocytes (50). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, deleting Dicer reduces T-reg cell numbers and immune pathology, indicating Dicer\u2019s importance in immune regulation and immune cell development72,73. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The AAP, AACO, AAPOS, and AAO disagree, citing studies showing increased benefit from detection and treatment of amblyopia earlier than age 3 30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with IBS-D had accelerated colonic transit compared with healthy controls examined with the same method that has been established in our laboratory for over 20 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a subgroup analysis, we evaluated whether this also affects the gut microbiome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Researchers recommended that this inverse relationship calls for a need-based framework for understanding active commuting in LMICs, versus the more common choice-based framework [50]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast to what Geddes and colleagues (2003) have observed for most of the studies included in their review, our trial provides a clear distinction between continuation and maintenance treatment, and thus also between relapse and recurrence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the enforced expression of NPM/ALK on the LAMA-84 cells led to an increase in the methylation of BIM 5\u2032UTR (Figures 6, E and F, and W5) and to the stabilization of a specific methylation pattern (Figure 6E). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observations are also in line with the previous findings [6,7,9,10,11,12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Common measures in videofluorography of humans to capture these deficits include number of swallows per bolus, festinated tongue movement, range of tongue movement, oral residue, and premature loss of bolus to pharynx, and disordered jaw movements for mastication and bolus transport [50] [11, 16-18, 35]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both instruments thus give the blood gas results at 37\u00b0C values. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, we found no evidence for catch-up growth in the present sample (i.e., child HAZ did not predict subsequent growth in any model). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Honsawek et al. investigated MMP-3-1612 5A/6A gene polymorphism with knee osteoarthritis in Thai population and indicated that the -1612 5A/6A polymorphism genotypes of MMP-3 gene promoter do not play a role in the development of osteoarthritis in the Thai population [2]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, heavy cannabis users trying to change make multiple, unplanned and short-lived attempts to change and even short periods of cannabis abstinence precipitate withdrawal symptoms but do not appear to increase alcohol and tobacco use. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A number of clinical studies have been initiated to answer important questions such as the following: Is very early prophylactic anticoagulation beneficial with regard to prevention of VTE and other relevant endpoints, e.g., hospitalization, need for ICU admission, mortality? ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genes involved in the control of the progression of the cell cycle from G1 to S phase that have been reported to be mutated in melanoma include TP53, CDKN1A, CDKN2A and CDKN2B. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, our study identifies novel putative melanoma susceptibility genes and provides insight into the biological implications of significant gene associations in melanoma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regarding PO10-4 and PO10-5, no epidemiological link could be made between the patients within the possible outbreaks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanism of development of bone pathology in patients with untreated coeliac disease is not fully defined, but chronic negative calcium balance16 caused by loss of villous surface area,17 binding of calcium to fatty acids in the intestinal lumen,18 and impairment of active intestinal calcium transport mechanisms because of depletion of calbindin from the enterocyte19 are all potential factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is consistent with the European consensus, which emphasizes the importance of achieving R0\u2010resection, either initially or after induction treatment for both metastatic disease and primary tumor after a multidisciplinary team discussion 6, 9, 23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, carbapenemase genes are often located on mobile genetic elements (13, 14), together with other resistance genes encoding resistance to antibiotic classes commonly used in veterinary medicine (e.g., tetracycline, sulfonamides, or phenicols). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the multiple comparisons in the locus by locus analyses in the Illumina dataset, one cannot rule out the possibility that this finding is the result of chance, and given that the independent sample set did not replicate this finding using an alternative method, we conclude that it is likely to be a false positive association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study compared psychological test data obtained from individuals approved for gender reassignment procedure with test data obtained from individuals who were rejected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite an adequate methodical approach, the present study did not reveal an association between MCP-1 \u22122518 A/G single nucleotide polymorphism and systemic sclerosis in Slovak population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, our study indicated that age is a risk factor for hypertension in residents of Xinjiang, which is also in line with reports from global epidemiological research, as the risk of hypertension increases with age [25,26]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We concluded that presence of unrelated atypical serum immunofixation patterns could be a possible laboratory marker of good prognosis in MM patients after ACST. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prospective surveillance data here indicate that there have been three widespread seasons of EV-D68 in Wales since 2015, lasting from 10 to 25 weeks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two gene pairs can predict which men would experience progression to the metastatic form of the disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First of all, current analysis failed to focus on information from diet such as salt intake, which was associated factors of hypertension. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A drawback of previous studies is the utilization of BMI at a single time-point as a predictor of subsequent obesity and cardiovascular risk4, 5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of these, 20 variants in 12 genes demonstrated larger effects in high grade cancer and an additional 24 variants in 17 genes were not associated with risk of overall disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, if the number of samples in each of two groups is 10 and the number of probes is ~10 000, the expected number of perfect classifiers that can appear by chance is 47.6=C210000220. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed and expected frequencies of these genotypes were similar, indicating that SLC4A1\u039427 and GYPC\u0394ex3 are independently distributed as would be expected under Mendel\u2019s law of independent assortment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, evidence shows that humans and other animals use alternative ways that have lower computational complexities than explicit search. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strategy may enhance newborn care by reducing the time to adequate antibiotic therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this regard, German study recruited SSc patients presenting with skin involvement while affection of other internal organs was not reported here [13] by contrast to our Slovak patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present disorder, however, the stimulation-dependent decrement of the CMAP is not owing to impaired resynthesis of acetylcholine and concomitant abnormal decrease of the EPP, but stems from a defect in Nav1.4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there are few epidemiological studies on hypertension, awareness, and hypertension associated factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another study reported that local surgical therapies for metastases, including hepatic arterial infusion, radioembolization, and transcatheter arterial chemoembolization affected the survival of the metastatic CRC patients 7, 24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In healthy adults, bacterial clusters within the phyla Bacteroidetes and Firmicutes usually dominate the intestinal microbiota, whereas the proportions of Actinobacteria, Proteobacteria and Verrucomicrobia are relatively small [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, there is a scarcity of literature revealing such relationships in children born healthy and full-term. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, the straw board could have been contaminated after manufacture by the feces, urine, birth products, or a corpse of an infected rodent that gained access to the inner layer of a straw board. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A number of studies, primarily conducted in rats with experimentally induced TBI, have demonstrated beneficial effects of progesterone on measures of working memory, spatial navigation, avoidance learning, and motor performance (see Deutsch and coworkers24 for a review). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore the vibrating sandals may have achieved half of the effect required to reduce onset of mobility disability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The data available for our research limited our ability to determine whether attributes other than density and distance, for instance the quality of resources, the average price for healthy and unhealthy food, or mobility (e.g., access to a car) (Sharkey et al, 2010a), could influence cardiovascular risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A retrospective study reporting typing results for 2,770 enterovirus samples submitted to the Public Health England Virus Reference Department during 2004\u201311, indicated that EV-D68 was only detected in 14 of 1,875 typed samples [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The comparative strength and limitations of the LCGMM method over other alternative approaches (e.g., tracing growth on a growth chart) are the subject of some debate37. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future Directions Despite finding positive tolerance outcomes, it is still unclear how specifically tolerance may develop and what specific psychological mediators led to these reductions within an Oxford House. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because we focused on only E-selectin expressions in this study, further studies are necessary to elucidate the detailed mechanism and role of the ANP\u2013GC-A system in cancer metastasis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SLC4A1\u039427 is considered to be a balanced polymorphism, where the selective advantage against severe malaria for heterozygotes outweighs the disadvantage of lethality in homozygous persons at the population level [12,13]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our results may provide very valuable information for excess weight loss is a critical public health priority in prevention of hypertension in Xinjiang residents. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our long-term goal is to connect stress mediated changes in cortical morphology to specific molecular mechanisms involved in neuronal network formation and modulation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RTX has been shown to be equally effective in treatment of ANCA negative GPA, suggesting that its effects are mediated in part via immune mechanisms distinct from autoantibody production. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been used successfully in the treatment of phantom limb pain in adults (Bone, Critchley, & Buggy, 2002), children and adolescents (Bone, Critchley, & Buggy, 2002; Rusy, Troshynski, & Weisman, 2001) and for cancer-related NP in adults (Caraceni et al., 2004) and children (Jacob, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the claims for modified allergens is to retain immunogenicity, and several studies have demonstrated that extract modification does not impair the therapeutic efficacy of the allergen extracts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was shown that keeping a nasogastric tube does not help in the reduction of the number of complications, but it slows peristalsis return, increases the number of respiratory complications, and prolongs LOS [29\u201331]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A limitation of the study is that the presence of attenuation artifacts could not be confirmed by the absence of any coronary stenosis at angiography. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rinaudo and Schultz [17] compared global patterns of gene expression in preimplantation mouse embryos derived from culture in 20% oxygen with that of 5% oxygen using the Affymetrix MOE430 chip. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, due to the cost, possible side effects, and the limited saving of homologous blood, intraoperative antifibrinolytic therapy may not be indicated in routine cardiac surgery. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estrada et al reported an odds ratio of \u22451.6 for those in the group with the highest risk score (9% of the population) compared to those in the middle group (34% of the population). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that epigenetic (60) and gut microbial (61) changes triggered by early-life inflammation moderate this pathway. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Others report only severe complications, frequently ignoring those complications that did not require intervention. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fentanyl doses should not exceed 0.5 to 1 mcg/kg/hr in order to minimize the risk of pruritus (Desparmet, Hardart, & Yaster, 2003), respiratory depression, and sedation. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We characterized this single gene disorder as a disease of vascular stiffening in the setting of gradual vascular stenosis, much like that seen over a lifetime in normative aging This study\u2019s human clinical investigations help us to translate the in vitro7, 9, 27, 28, 33, mouse model9, and human pathologic4, 26 support for key roles of altered lamin A and progerin in human aging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The original article by Wayne Bolton in 1958 studied a sample of 55 females with excellent occlusion to detect the ratio of tooth size discrepancy 16,27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using ChIP experiments, we demonstrated the involvement of histone H3 tail deacetylation, a well-known marker of chromatin condensation [50], in BIM silencing (Figure 4, A and B). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, convenience sampling is a common practice in HIV research, and it would be difficult to obtain a truly representative sample because of stigma related to the disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may account for the greater treatment effect in patients without diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study showed that an increased NLR is an appropriate indicator for prenatal diagnosis of HCA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "5 Studies using viscoelastic whole blood assays have demonstrated significant hypercoagulability due to a severe inflammatory state in COVID-19 patients requiring ICU admission, 31 32 further arguing against DIC as a universal finding in advanced disease stages. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Echodensity in the HGPS cohort often saturated the upper limit of detection; technical expansion of the 256 gray scale would allow additional density capture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contaminated fomites can produce secondary aerosols of C. burnetii sporelike forms (4), and several outbreaks have demonstrated the possibility of spread on fomites such as clothing, straw, hay, contaminated shoes, and building materials (22,25\u201336). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study does not capture those febrile illnesses that did not lead to hospitalization\u2014either because adequate care was obtained elsewhere, or because barriers to hospital care were insurmountable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Paracetamol decreases acute dental pain [24] and is commonly used by patients who have dental pain [25\u201327]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most transaminase elevations improved to grade 1 or to pre-retreatment levels within 15 days, and less than 2% of cycles had recovering times longer than 25 days. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed that opioid-related complications did not significantly differ between LPN and RAPN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study has brought forth important findings that may contribute to improving the health of Nepalese adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a pooled analysis of cohort studies, dietary lutein/zeaxanthin intake was associated with a slightly reduced CRC risk24, and a similar association was found for the risk of colorectal adenomas in a cohort of male health professionals25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main finding of this study was that transsexual individuals present profiles that are relatively free of psychopathology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Liver tests abnormalities, defined as grade 3/4 transaminase elevations, are common events during treatment with trabectedin. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some authors have suggested that the MMPI scores of transsexual individuals should be interpreted using the normative data for the subject\u2019s gender identity5,28,36. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The very high (>95%) response to the booster dose is reassuring in the case of professional exposure to wild-type HBV, even in professionals with non-protective HBsAg antibody titers at the time of the accident 23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Estonian and Croatian HIV patients, ARV treatment did not appear to have an effect on QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At last followup, the incidence of thigh pain was 0.8%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a further analysis of the prognostic value of the cellular subpopulation of CTCs, we found that CRC patients with high expression of CD133+CD54+ (P < 0.001), CD133\u2212CD54+ (P = 0.004), and CD133+CD44+CD54+ (P = 0.003) subpopulations of CTCs had a worse survival than those with low expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The stress paradigm used by Bock and colleagues is closely comparable to our stress protocol. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transport industry workplaces, including truck cabs, truck depots and truck stops, are increasingly recognized as settings conducive to health promotion 3. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Curve slopes for both extracts were not significantly different, indicating that there were no changes at IgE epitopes due to the chemical modification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early surgery with standardized antibiotic therapy may be necessary for patients who are likely to fail medical therapy yet have sufficient predicted postoperative pulmonary function. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the Infinium HumanMethylation 450 BeadChip, due to its probe design, does not interrogate repetitive elements which are found to be differentially methylated in many cases of neoplasia [28], [29]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The differential condition effects maintained though the regression analyses even when controlling for socially desirable responding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, since we used a single blood sample to calculate NLR, it is uncertain whether a single sample could reflect an elevated NLR over time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If (b) is answered in the negative, the medical referee may, under Regulation 12 of the Cremation Regulations (1930), prevent cremation4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found no such overestimation in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We determined the incidence of CIN using a common definition (raise in serum creatinine of \u226525% and/or \u22650.5\u200amg/dL), that has been validated in many studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The postoperative period often coincides with an intensive physical rehabilitation program (continuous passive movement, strengthening and stretching, assisted ambulation) that requires ongoing pain interventions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Culturing embryos in low oxygen concentration improves embryo utilization rate and increases the chance of pregnancy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be considered that COVID-19 patients may be immobile for a while before hospitalization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the case of significantly elevated D-dimer levels (\u22651.5\u20132.0\u2009mg/L), pharmacological VTE prophylaxis should be initiated and hospitalization be considered, regardless of the severity of clinical symptoms. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it is apparent that the incidence and prevalence of bone metastases are difficult to determine with accuracy, and there are no studies concerning the incidence of bone metastasis as the first sign of generalised metastatic disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, there are disturbingly low rates of HCV screening among a high-risk SMI population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Solid cathode, liquid electrolyte systems such as the lithium/carbon monofluoride and lithium/manganese dioxide pacemakers have greater gravimetric energy density (watt h/mm3) and are therefore likely to be future cardiac pacemaker power sources10. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The motivation is increased stimulated surveillance in next step for the development of kidney disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A possible limitation of the present study was the sample size. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the coordinates of food vendors were obtained in 2016, which was four years after the third follow-up data collection in APCAPS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was done by using the robust Illumina technology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We were also cognizant of the importance of noting the reasons why a particular test could not be administered. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only some authors use Clavien-Dindo classification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general, microorganisms can activate monocytes, tissue macrophages, and endothelial cells, thus triggering the production of proinflammatory cytokines and activation of the coagulation protease cascade. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data indicate that TNF but not TNFR1 or TNFR2 causes podocyte apoptosis (Figure 3G). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results, furthermore, might indicate that prayer has a positive relationship with pain tolerance for CP patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has several important limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, no relationship was observed between the ratio of Bacteroidetes and Firmicutes and diets low in carbohydrates [26]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, we make the following observations and recommendations: Cohort Selection Ascertainment according to broad criteria can give only limited enrichment of rare variants. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, using high-quality data obtained in a systematic and standardized approach, hypertension was used to construct a prediction model for the multiple ethnicity population, as similar studies have not been reported. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Any model, in the best of circumstances, can only serve as an approximation to the human clinical situation it is designed to reflect. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further risk factors such as advanced age, comorbidities, and history of VTE may result in thromboembolic complications even after successful treatment of the SARS-CoV-2 infection and discharge from hospital. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First of all, given the cross-sectional design of the study, we could not demonstrate temporality of the associations observed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, in a study of oxandrolone's effects on adult tetraplegia patients, Spungen et al found a significant combined improvement in measures of spirometry [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is widely accepted that development is plastic and the sensitivity of the epigenetic system to environmental factors is heightened during periods of developmental plasticity such as childhood, adolescence and puberty [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, for example, one patient had a positive C. trachomatis IgM of 1:40, and an elevated C. pneumoniae IgG titer of 1:256 (Table \u200b(Table2).2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast to CVID patients, IPH and IgGSD patients did not have significant alterations in mean cTfh cell levels, in mean chemokine receptor expression on B and T cells, or in mean ICOS upregulation on activated T cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the possibility that other local factors contribute to TNF pathway activation in podocytes exposed to patient sera should also be considered. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such experiments could test the effect of variables like the mean and the variance of cached values on the probability of expanding a node. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the meantime, Kim et al. reported a 10% complication rate in their group [38]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Excess weight loss is a vital strategy for controlling hypertension, particularly if accompanied with other preventive measures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disadvantages related to THA surgery, such as dislocation rates and revision rates, are relevant to include in the investigation of potential differences between the 2 surgical approaches, but this would require a longer follow-up and a study design with a larger sample size (Jolles and Bogoch 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to give the complete and true picture of the pathogenicity and fitness of ST410. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As with any retrospective investigation, there exist several limitations associated with our analysis that may impact clinical translation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, establishment of an institutional biorepository for banking of serum, urine, stool, and tissue samples should be considered \u2014 only with the committed and coordinated efforts of the entire health-care team will we find answers to the many questions that remain.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings indicated that DICER1 rs3742330 AG heterozygotes were associated with an increased risk of CRC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that different BMIz trajectories in the first 2 years reflect differential changes in body composition (fat vs lean mass) and are more predictive of body composition and obesity in later childhood than a single time point assessment of BMIz at 2 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It\u2019s not a matter of skin color, it\u2019s only a matter of clean, how clean you are, how willing to be a part of this, just your willingness to be clean is all that matters.\u201d ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the study did not focus on changes in these components, particularly since the study relied on self-reported food records making it difficult to correctly estimate phytonutrient intake. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ABL 800 flex warms the blood to 37\u00b0C before analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although there is certain similarity in clinical manifestations of hepatitis induced by these viruses and creating background for subsequent development for LC and HCC, their molecular organization, replication strategy and functions of constituent proteins are different. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this method is not widely performed because it is relatively difficult in practice and the cost is high. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One potential limitation of this functional annotation study was that we had no access to the whole genome-wide set of summary statistics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relationship between age of individuals and the prevalence of macro-lesions (based on post-mortem) was stronger than that between age and prevalence for individuals that were lesion negative and culture positive. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, our sample size was moderate (201 participants) and we might have missed some true associations because of lack of statistical power. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The finding of greater effect on those with elevated DBP could relate to meticulous focus by the intervention MTM pharmacists on both SBP and DBP when considering further treatments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One retrospective study recommended that patients with localized NTM lung disease be considered for pulmonary resection as early as possible (14). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The maximum acceptable bupivacaine infusion rate is 0.4 mg/kg/hr for older children and adults and 0.2 mg/kg/hr for infants (Verghese & Hannallah, 2005; Yaster, Tobin, & Kost-Byerly, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the proposal has been made that the amodal semantic hub may actually reside in the anterior fusiform gyrus, which was not a major site of peak atrophy in most of our patients, there are also cogent reasons for questioning such a location (Snowden et al, 2004; Mion et al, 2010). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The same applied to the secondary outcomes except for limping, where patients in the PA group improved more than the patients in the LA group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of technical differences between LPN and RAPN, we expected to observe the difference in postoperative pain intensity between the 2 modes of surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, with respect to DICER1 related cancers, several studies have suggested that loss of function or mutation of DICER1 may affect stem cell proliferation, differentiation, and cell fate and induce embryonal or blastoma carcinomas17,51,52. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the former case, our algorithm represents a collaborative interaction between instrumental model-based and Pavlovian processes [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Release of separase in this process also activates CDC14 in a positive-feedback loop, in which CDC14 dephosphorylates securin for continual ubiquitination by the APC [18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We do not know of other studies of how quickly cannabis users trying to quit on their own relapse. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Korea, according to Lee et al., as monthly income and education status increase, there was more severe atopic dermatitis populations observed [42]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are various ways that information can be obtained about cancer and early diagnosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical procedures induce postoperative complications and early recurrence after surgery by releasing inflammatory cytokines, such as IL-1\u03b2 and TNF-\u03b1 (1, 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contextual skills comprise practical matters such as planning meals, considering what food is good for oneself and having regular meals [8]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the steep relapse observed in this study is similar to that of self-quitting in tobacco smokers (Hughes, Keely, & Naud, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To sum up, it may be asserted that, if in individual cases ventral spondylodesis is feasible, this method should be used.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Remarkably, when only LOS variables were included in the regression model and covariates were controlled for, all but one measure (DCL) were significant DHI predictors (Model 3, Tables 3 and \u200band4).4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In four patients fractures occurred after they had started on a gluten-free diet. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other studies by Kwon et al18 and Giles et al17 also identified four BMI trajectories with similar patterns; those studies utilized a different technique known as group-based trajectory modelling, however, which assumes no within-class variation (i.e., variance in each subgroup is fixed to zero)8. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although problematic for the identification of an association, we nevertheless note that the existence of multiple different GSVs may be of great utility in dissecting a locus whose association has been conclusively demonstrated. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients who reported lower salt intake may have been more physiologically responsive to treatment with diuretics, a mainstay of treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of course, the prayer\u2013health dynamic can be a reciprocal process whereby higher levels of pain lead to higher use of prayer which, in turn, decreases the detrimental effect of pain on daily life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Li et al. [13] showed that surgery time, blood loss, conversion to laparotomy, and preoperative morbidity after posterior radical hysterectomy performed following conization varied with the time interval, and indicated that the appropriate time interval was 6 weeks after conization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Local production of angiogenin is strongly suggested by our finding that angiogenin is released in large amounts by synovial fibroblasts from joints with active or chronic synovitis (Figs 3, \u200b,4).4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Control Measures Risk assessment and risk management was undertaken by identifying groups of persons at different levels of risk and providing relevant advice, temporarily stopping work in the area of the building considered at greatest risk, and following identified patients with Q fever. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the treatment of M. abscessus lung disease, combined intravenous antibiotic therapy including amikacin and cefoxitin for 2-4 weeks for clinical and microbiologic improvement was recommended in addition to the oral antibiotics, including clarithromycin (or azithromycin) (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, among the Danish ST410 isolates, 20/49 (41%) were from bloodstream infections, which may qualify for severe infections, and show a potential for enhanced pathogenicity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epigenetic modifications in response to environmental exposures at these critical periods are often subtle initially and even though they do not lead to phenotypic changes at the time of exposure, they may lead to increased risk of dysfunction and disease later on in life [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence found in this study is similar to the prevalence of self-medication (30%) reported in previous study by Simon et al, [10], and lower prevalence than a study by Jain et al, [11], where approximately three-quarter of the participants (72%) practised self-medication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a study of more than 2,000 older white participants (median age at first assessment 77 years) who were assessed longitudinally for progression to MCI or AD the CLU rs11136000 risk allele was associated with lower scores at baseline on a test of paragraph delayed recall from the Wechsler Memory Scale-Revised Logical Memory subtest but not with 5-year decline in verbal memory while no associations were found for the other eight loci [Carrasquillo et al  2015]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although this was not a primary end point, our study was sufficiently powered to detect a clinically meaningful difference in the inflammatory cell infiltrate in the two groups on the basis of HLA-DQ status. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An epidemiological link was found among patients P2 to P8. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, information regarding valvular function, wall motion, and other concomitant cardiac disease can be obtained. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here we show for the first time in a relatively large cohort of subjects that there is a spectrum of peripheral immunophenotypic abnormalities in PAD, ranging from those present in AFM across those found in IgGSD and IPH patients to those in CVID patients, with the differences being most notable in na\u00efve and memory T- and B-lymphocyte subsets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, there were no significant differences in opioid requirements between the 2 groups from POD 1 to POD 4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the rat model, we have also shown biting and chewing deficits in a 6-OHDA model in rats while eating pasta [71]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These constraints disproportionately affected poorer households, but were a problem for less poor households as well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These patients continued to receive additional attention to their elevated BP during the study as a result of quality improvement efforts, while patients without diabetes did not. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, we measured seminal plasma HIV-1 RNA and did not quantify cell-associated virus. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bone scanning is the most useful study in assessing patients with suspected metastatic skeletal disease because of its ability to detect asymptomatic disease approximately 4 months on average before a lesion can be identified by plain radiography [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anticoagulation for VTE should be continued for 3 to 6 months. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, mediation analyses showed that the cognitive activity of positive re-appraisal mediated the relationship between prayer and pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A potential pitfall of our study is that patient participants were not selected on the basis of a history suggestive of gluten sensitivity or a prior response to gluten withdrawal. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrates that parallels can be drawn between the phylogeny and emergence of fluoroquinolone and ESBL resistance (CTX-M-15) in ST131 and ST410. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the function of DICER1, influenced by rs3742330 plays a pivotal role in CRC tumorigenesis by altering the expression of miRNA-related oncogenic pathways underlying cellular transformation, such as proliferation, apoptosis, invasion, and metastasis67. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies will be needed in selected pathophysiologies to further generalize sex differences in cortisol feedback. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because there is no biomarker that can be used to confirm the clinical diagnosis and there is often a mixture of vascular and AD pathology found on autopsy [Fernando et al  2004; Lopez et al  2003b; Schneider et al  2007], genetic studies of AD based on case status may be complicated by substantial phenotypic heterogeneity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hysterectomy, one of the most common gynecologic surgical procedures, can be performed via vaginal, abdominal, or laparoscopic approaches [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, we analyzed the DICER1 rs3742330 genotype to determine the association between lutein/zeaxanthin intake and CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the highly complex nature of cholesterol-mediated cell injury in vivo requires further investigation, as other studies yielded conflicting results showing either protective or detrimental effects of esterified cholesterol accumulation in atherosclerotic phenotypes (56). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finding optimal or near optimal actions requires comparing the expected value of all possible plans that can be taken in the future. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this preliminary work does provide data that can be useful for conducting a more scientific assessment of the problem. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the need for rescue analgesics led us to speculate that OIH was playing a role. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results provide new base line data about arch form and dimensions as well as the Bolton ratios, which can be used clinically in diagnosis and treatment planning of patients living in the city of Jeddah. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, minimizing these artifacts and improving the uptake of attenuated segments is likely suitable for better assessing myocardial ischemia and necrosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may provide an alternative HLA-independent mechanism to explain the increased permeability in IBS-D. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests several potential mechanisms that account for the interaction between lutein/zeaxanthin and DICER1 rs3742330 regarding CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In total, at least 15 clinical trials and the most recent meta-analyses demonstrated a reduction of contrast-induced renal impairment by prophylactic administration of theophylline, an adenosine antagonist 7,16,25,26. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, we sampled only daily cannabis users who were intending to quit or reduce at some point in the next 3 months. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In their study, Wistar rat pups, with and without medial frontal cortical lesions, were exposed to what was intended to be a \u201chandling\u201d paradigm, from postnatal day four to weaning. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a first conclusion, our data indicate a correlation between walnut consumption and a shift within the gut microbiome, suggesting that a regular supplementation might offer prebiotic and probiotic benefits by improving the microbiome composition and diversity. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to Sundell et. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A study of 30 severe enterovirus infections in children from 2012\u201313, in the south of England did not find any association with EV-D68 [9]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To describe the coagulation changes in COVID-19 patients, the term CAC (COVID-19-associated coagulopathy) has been introduced 27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first study that reports CD133+CD44+CD54+ subpopulation of CTCs has a prognostic value in CRC patients with liver metastases, especially those who did not receive surgical treatment for metastases (P < 0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The speed of a muscle fiber contraction is closely related to myosin heavy chain (MHC) composition within a muscle [7]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two of these, PO10-1 and PO10-2, carried blaCTX-M-15 and blaCMY-42, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This rapid relapse rate suggests \u201cfront-loaded\u201d treatment with multiple contacts in the first week of a quit attempt (Garvey et al, 2012) should be considered. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results are comparable to previous Australian research, which found 28.0% and 89.0% of drivers consume fewer than the recommended number of serves of fruits and vegetables, respectively, per day.11 Drivers consume more unhealthy food and drink per day than Australian recommendations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, when considered together with E2 levels, T concentrations in men and women are positive correlates of both mean and pulsatile ACTH secretion, at least during pulsatile cortisol inhibition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient selection, careful preoperative planning and improvement in surgical technique have dramatically reduced our operative fracture rate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It seemed that EIT was superior to compliance in scanning the \u201cideal\u201d PEEP, even if the difference about this \u201cideal\u201d value was slight (8\u200acm H2O PEEP for the E group vs 10\u200acm H2O PEEP for the C group). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Processes within the transtheoretical model of change used in the addiction literature may provide insight into increases in tolerance (Prochaska, Norcross, & DiClemente, 1993). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The impact of health care professionals on Turkish citizens is very high. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In three patients, this was the only conspicuous abnormality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach also enabled the identification of specific genes that might be involved in the mechanistic pathways linking menarcheal age with disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The renovation of buildings has also been suggested as a source of Q fever in two previous outbreaks (26,39). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The verbal definition of object pictures, however, is dependent not only on access to object representations but also on the integrity of the language network needed to mediate the transcription of non-verbal concepts into a verbal account. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When examined individually, sex and age both were found to be significant predictors of social anxiety, with females and older adolescent reporting more symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because people with SMI utilize public mental health clinics rather than primary care,12 these clinics are their medical home 13. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, approximately 3% of the total variance in BMD was explained by the GRS63 and, considering that \u224560% of the total variance in BMD is genetically determined, this would be equal to the GRS63 explaining \u22455% of the total genetic variance, being of the same magnitude as found in the original GEFOS publication (15). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although experimental work is necessary to elucidate this further, it does suggest that external lesions only manifest themselves during the more advanced stages of the disease, primarily encountered in older individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative nausea and vomiting (PONV) was lower in group R, whereas itching and urticaria were lower in group N. Opioids and inhalant anesthetics are both known to be major risk factors for PONV,24,25 whereas propofol is known to reduce the degree of PONV26\u201329. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The difference was not statistically significant in the per-protocol analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with other international studies from both high-income countries and LMICs, the strongest correlate of active commuting and use of public transit was land-use mix [43,60,61,62]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strategy had inadequate statistical power to detect most true effects of less significant SNPs in a typical GWAS, which includes only a few thousand individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We can hypothesize that transsexual individuals without hormone therapy tend to be centred on their own difficulties, depressed, and uncomfortable with other people. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre-implantation knowledge of the venous anatomy may help determine whether transvenous left ventricular lead placement for CRT is feasible.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, the study sample was drawn from only four secondary schools of Birgunj, which could limit the generalisability of the results in different settings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While eating walnuts, subjects were instructed to either reduce fat, carbohydrates or both. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This observation can be partly explained by an upward LV displacement, as previously documented for prone comparatively to supine positions (24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bedaiwy reported that high ROS levels on day 1 in the culture media are associated with a low fertilization rate, low cleavage rate, and high embryonic fragmentation during ICSI cycles [14]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All hospitalized COVID-19 patients should receive pharmacological VTE prophylaxis in the absence of contraindications. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional investigation will be required to elucidate the extent to which observed sex differences in cortisol feedback modulate an individual's response to classical stressors (24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The goal of this investigation was to explore the spared and impaired aspects of word and object knowledge associated with this relatively focal neuronal loss at the tip of the left temporal lobe. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Yet, we hypothesized that the GRS63 might capture more of the variation in BMD and thereby more of the fracture risk than the subset of SNPs included in the GRS16, and, therefore, we compared the performance of these two genetic risk scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This would indicate that regardless of treatment, bone metastases will appear in a certain number of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a recent study by O\u2019Sullivan et al (2018) found that 38% of overdose patients treated in accident and emergency departments are caused by dental pain [25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aminoglycosides serve as a benchmark class for the principle of dosing antibiotics based on body size and renal function, though the choice of the right scalar of weight to use in these calculations has been debated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since randomization is performed only at the beginning of the study period to which it applies, the validity of the treatment comparison for a specific phase is not compromised by selection bias resulting from the outcome of the preceding period (M\u00f6ller, 1986; Montgomery, Kasper, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although NP is not uncommon in cancer patients, only a small number of clinical research trials have specifically assessed analgesic drugs for cancer patients with NP (Caraceni et al., 2004; Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Namely, a sequential decision-making task has demonstrated that humans use strategies such as \u2018fragmentation\u2019 and \u2018hoarding\u2019, in addition to pruning, for efficient planning. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To date, several molecular genetic studies have implicated a number of genetic variants in hepatitis-related LC including two GWASs, each of which revealed two independent susceptibility loci for LC20,21. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, while reduced ABCA1 expression alone is not sufficient to cause podocyte injury, simultaneous pharmacological inhibition of the conversion of free cholesterol to esterified cholesterol in ABCA1 knockdown podocytes was sufficient to cause cell injury (Figure 5). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we demonstrated that postoperative infections following hysterectomy performed within 2 weeks after conization were more common and severe than those occurring following procedures conducted 3\u20136 weeks after conization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The time during which hysterectomy could feasibly be performed after prior cervical conization has not yet been determined. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The finding that the CS ostium is ovally shaped agrees with observations in other cardiac veins [4, 5, 9]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mechanisms Accounting for Reduced Availability of Functional NaV1.4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This regime in combination with bicarbonate and theophylline could be a promising way to further reduce the incidence of CIN and should be investigated in randomized trials. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients may be more apt to believe a navigator they have come to trust, who communicates in a culturally sensitive and accessible fashion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Simple steps such as the duplication of the two statutory questions on form B to the coroner's form E, along with a question about implantable devices on the relatives' form A, might help reduce the number of explosions in crematoria. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings are consistent with other studies investigating the effect of a walnut-enriched diet on the gut microbiome (consumption of 42 g/day walnuts over a period of three weeks) indicating a significant (p < 0.05) increase in the relative abundance within the Clostridiales order. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as poverty and health disparity in perinatal determinants of health are both recognized problems facing the Native Hawaiian community,28,29 it would not be surprising to find that Native Hawaiian children may also be at risk for under-diagnosis and under-treatment of vision disorders. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The MMPI-2 is one of the best standardized methods for assessing the psychopathological profile of adult populations aged 18\u2009years and over, including transsexual individuals5,36,53,54. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence of CIN in group S (9.0%) is in line with the incidence of CIN in patients who received theophylline in the recent meta-analysis of Dai et al7 (7.9%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, given the multi-factorial nature of falls, a change in gait variability alone may not be able to overcome the effect of other pathologies or risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that, in addition to the energetic demands of developing a large and complex brain (12), immune activity considerably constrains the energy available for childhood growth (14). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite their improved performance characteristics, cardiac CZT cameras are still considered to provide suboptimal specificity for identifying significant coronary artery disease (23), and attenuation artifacts potentially play a substantial role in this setting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Environmental and epidemiologic evidence suggests that this outbreak was associated with the renovation of an office block within a cardboard manufacturing plant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are many issues that remain to be addressed when seeking to identify GSVs that are associated with complex disease, several of which are highlighted by this study; some of these issues are also relevant to the analysis of rare variants identified by sequencing approaches [31], [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the point of arrival at the referral hospital, a majority of households had already extended beyond their savings to pay for medical care, incurred debts that would require repayment, and reached the point of catastrophic expenditure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These benefits include faster gastrointestinal recovery, decreased postoperative nausea and vomiting, and improved wound healing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, to make the data of this study comparable to previous and future trials on prevention of CIN, we chose the most frequently used definition of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding replicates other single-grade studies but with a different population of students and teachers and with a control group that received the same amount of professional development, albeit in mathematics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A strength of this study is that we performed a comprehensive evaluation of variation in mitotic genes and risk of breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our findings reinforce the need to take into account measures of emotional status when investigating subjective symptoms and their relationship with objective balance measures in TBI. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for the Etiology of Growth Faltering. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This does not imply that there could be no other clinically signifi cant differences than those investigated in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients randomized to WS\u00ae 5570 receive the same dose during long-term treatment as well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using a similar comparison but for incident fractures, we found in the present study an HR of \u22451.4 and \u22451.2 for GRS63 and GRS16, respectively for those in the group with the highest risk score compared to those in the middle group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding can be explained by the potential antioxidant activity of the cumulus cell mass and normal spermatozoa present inconventional IVF cycles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Instead of applying commonly used measures of the human swallow, which don\u2019t directly translate to the rat, we focused on more specific measures of rat deglutition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the association between genetic variants in CLU (rs11136000), CR1 (rs6656401 and rs3818361), and PICALM (rs3851179) and several tests of memory was analyzed cross-sectionally in 2 groups of 268 African-Americans and 2,651 whites that included both AD cases and controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The fallers showed greater variability than the non-fallers suggesting that variability may be associated with falls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Engagement initiatives should offer education on the recognition of warning signs (such as reduced level of consciousness) that should prompt a provider to refer a patient to a qualified doctor or hospital. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that the combination of CRP level and NLR may help to improve prognostic accuracy in patients with PIR. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, mindfulness could change by training on meditation and previous exposure [9; 30], which has not been assessed in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many of the group and interactive factors establish a set of new setting norms and reinforce super-ordinate goals, such as overcoming substance abuse, even if residents share only minimal other preexisting characteristics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports the finding of Othman and Harradine,29 O\u2019Mahony et al,30 and Asiry and Hashim31 in the Saudi sample, in which they found no significant gender dimorphism on Bolton\u2019s ratio. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparable results could be observed in a trial in rats showing significantly greater species diversity after ten weeks on walnut diet by increasing the abundance of probiotic-type bacteria including Lactobacillus spp., Ruminococcus spp. and Roseburia spp. [34]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We were also unable to account for childhood dietary patterns or physical activity at 5 years, which may reflect exposure to an obesogenic environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "International collaboration is needed for a better understanding of the temporal and geographical pattern of circulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C. trachomatis IgM antibodies by MIF testing appear to be less heterologous than IgG antibodies, and are observed after primary but not repeat exposure to C. trachomatis 1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of 3 GSVs present in >0.1% of subjects, 2 showed association with changes in BMI at or near nominal significance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data indicated that Korean adolescents' smoking rate was relatively low among OECD countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports that circulating TNFR1/TNFR2 may represent a compensatory mechanism to elevated local TNF. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several mechanisms of BIM regulation have been described both at the transcriptional and posttranscriptional levels [20,39\u201344]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical benefits of immunotherapy can be achieved more rapidly, safely and with fewer injections by use of polymerized pollen allergens instead of the conventional native extracts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inaccurate verbal definitions of words provide reasonably reliable indicators of impaired word knowledge because the input and output stages of the task are both confined to the language network. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have been published in which EIT was used to assess mechanical ventilation in intubated patients 21\u201323. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The first laparoscopic total gastrectomy was successfully performed by Azagra et al. in 1993 [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, for this group of religious affiliated patients high levels of prayer were also related with more pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates that glutaraldehyde-polymerized allergen extracts of P. judaica used in accelerated schedules are safe to treat P. judaica-allergic patients, inducing blocking antibodies and reducing levels of specific IgE to a major allergen. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The measures of heightened cortisol feedback included ACTH secretory-burst mass, pulsatile, basal, and total ACTH secretion, as well as ACTH ApEn. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been stated that most metastases occur approximately 1 year after diagnosis [3] and that the most common site of bone metastases is the vertebrae [5]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent systemic review suggested that arterial hyperoxia was associated with poor hospital outcomes[Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent meta-analysis focusing on patients with renal impairment was able to show a benefit for bicarbonate 15. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Body weight was only a marginal factor in this estimate, as CrCL determined without using weight still explained 21% of the variability in this parameter. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, Bongartz and colleagues outlined the four major cardiorenal connectors: increased activity of rennin-angiotensin system, oxidative stress, high activity of the sympathetic nervous system, and, in particular, inflammation and cytokines [23]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With an expected KIR Best frequency of 11, KIR Better 20% and the remainder being KIR Neutral, selection of fewer than 4 donors per search would hamstring the likelihood of identifying a KIR Best or Better donor beyond those available in the random population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding highlights the primary function of body fat in meeting energy shortfalls among humans (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, Lee et al reported that there were no differences in postoperative opioid consumptions and pain intensities during the first 24\u200ah in patients undergoing isoflurane anesthesia with 70% nitrous oxide or with 0.17\u200a\u03bcg/kg/min remifentanil infusion for open colorectal surgery18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent systematic review pointed out that relatively few studies have analyzed outcomes by patient baseline variables[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent experimental reports demonstrated that inflammatory chemokines including chemokine ligand (CCL) 2 and CCL5 contributed to not only leukocyte recruitment but also tumor cell homing to activated endothelial cells (33, 34). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, bone metastases occurred approximately 17 months after initial diagnosis of the solid tumours, and the majority of bone metastases were in the lumbar spine (Table 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The same view can be also put forward in the present study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, during cremation, when temperatures reach 1300 \u00b0C (2400 \u00b0F) for 90 minutes, iodine forms a gas that rapidly expands, causing the pacemaker casing to burst. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A growing body of evidence has indicated that the up- and downregulation of DICER1 are related to the development of tumorigeneses such as lung, breast, ovarian, skin, prostate cancers, and CRC via the alteration of miRNA expression17,20,50. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The one patient with prominent impairments in both grammaticality and repetition, Patient S5, was also the only subject to display a small, but significant, patch of additional atrophy in the temporoparietal junction, including the posterior tip of the superior temporal gyrus. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here we demonstrate that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients, suggesting that ANP could potentially be used to prevent cancer recurrence after surgery. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether progression of initial coagulation changes to SIC or DIC is a characteristic feature of COVID-19 and not caused, e.g., by ARDS, septic shock, or ECMO therapy is currently not clear. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cluster XIVa) and are highly abundant within the human microbiome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although HCA and amniotic fluid culture tests are useful in diagnosing intrauterine inflammation and predicting the prognosis of a neonate, they have drawbacks, such as the time needed for culture and the high possibility of a false negative result due to various causes. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some limitations of this study must be mentioned. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the questions we used for self-reported stress level are standard, and similar questions have been used in other studies such as a Canadian nationwide health survey where self-perceived stress level was assessed by choosing among the five categories: (1) not at all, (2) not very stressful, (3) a bit, (4) quite a bit, and (5) extremely stressful [48]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Perspectives The HGPS vascular phenotype is associated with significant premature cardiovascular morbidity and mortality occurring in the absence the common comorbidities that are prevalent in adult populations, such as smoking, hypercholesterolemia and obesity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The choice of the correct model and number of classes in LCGMM is also not always straightforward. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trabectedin treatment has shown to be reasonably well tolerated during its phase II and III clinical development. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Type of glucocorticoid may be relevant, given protein-binding, kinetic, and brain-uptake differences between synthetic and natural glucocorticoids (7, 12, 22). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If age at menarche is related to methylation patterns in these repetitive elements, the hypomethylation would not have been evident in the 450 K chip but it would have been detected in the LUMA assay. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several case-control studies (Grattarola et al, 1974; McFadyen et al, 1976; Adami et al, 1979; Secreto et al, 1983; Hill et al, 1985; Secreto et al, 1991) have reported that a significantly increased risk of breast cancer in post-menopausal women is associated with high levels of testosterone in serum and urine. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As obese people try to reduce caloric intake\u2014oftentimes through increasing f/v consumption and PA\u2014their hormonal pathways change, causing them to face increased appetite and desire to eat [18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, elevated local TNF expression was shown to reflect disease severity better than systemic TNF levels in several inflammatory diseases (39, 40), and reduced renal TNF expression was shown to correlate with reduced albuminuria independently of serum TNF levels in mice (41). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The exact incidence of bone metastases is still unknown, although the skeleton is one of the favourite sites for the metastasis of many malignant neoplasms [3]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In all, three patients in group 1 and one patient in group 2 died in the first and fourth year after the operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment of granulomatous lesions, in addition to the vasculitic component of GPA, is critical to inducing disease remission and minimizing patient morbidity, but is often harder to achieve and frequently entails the use of cyclophosphamide. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pure retrieval anomias accounted for 25% or more of all naming failures in six of the nine patients for whom all relevant data were available. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While both SLC4A1 and GYPC play an important role in red blood cell morphology and function, the genes that encode these proteins are located on different chromosomes [7,19,20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "What is important is that in 45.8% our patients iv fluids were stopped within 24 h postoperatively and were replaced with oral intake. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Assessment scales specific for NP have been described (Bennett, 2001; Galer & Jensen, 1997), but the traditional Faces Pain Scale (FPS) and Numerical Rating Scale (NRS) meet the requirements of validity and reliability and are extensively used in pediatric pain management. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the relative error of the CDI estimated pH could be even more pronounced than the 9 \u00b1 2.6% obtained with the values from the display of the CDI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, serum creatinine shows a paradoxical inverse relationship with disease relapse; higher serum creatinine levels are associated with lower risk of relapse.4 Therefore, although localized and early systemic GPA lack organ or life-threatening manifestations, persistent granulomatous inflammation is difficult to treat and exposes patients to significant risks associated with long-term immunosuppression.23 The use of methotrexate, in combination with glucocorticoids, has been advocated following a randomized controlled trial, which demonstrated its equivalence at inducing remission in early systemic disease compared to oral cyclophosphamide. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pacemakers now in the design stage will be potentially more explosive and also more difficult to detect post mortem: both manufacturers and patients favour smaller pacemakers that have greater energy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We could not locate a prospective study of the incidence of long-term abstinence among cannabis users who try to stop on their own; however, the 8% success rate in this study is almost identical to that for tobacco self-quitters (Hughes et al, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Public health policies designed to improve the healthiness of neighborhood food environments by increasing the availability of fruit and vegetable vendors and restricting highly processed and take-away food vendors should be encouraged in south India and other rural communities in South Asia. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the data on the functional significance of MCP-1 \u22122518 A/G SNP are not consistent [13, 16], and the investigated SNP is not the only factor involved in regulation of MCP-1 gene transcriptional activity [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We detected both elevated and depressed ABI in HGPS, which likely reflects a composite picture of peripheral vascular stiffening and occlusive disease that could actually yield misleading normal ABI values in this mixed disease setting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intriguingly, the second nominally-significant association was between deletions within the FOXP2 gene and decreased BMI, an effect in the opposite direction to that previously reported for the locus. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depolarization induces outward movement of all four S4 voltage sensors, but fast inactivation is only linked to S4 movements of domains III and IV (30). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An optimal community service would prevent a majority of hospital admissions by providing diagnosis and treatment early, while fast-tracking those cases that require urgent escalation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another strength of the study is that the data about socio-demographic and disease-related factors were obtained from medical records, decreasing the possibility of information bias. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analytic approach was reasonable for assessing patient characteristic subgroup in which the treatment effect was larger or smaller than in other subgroups (\u201cdifferential effectiveness\u201d). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As outlined above, multiple studies have implicated CLU in analyses of cognitive function providing increased plausibility for the findings reported here. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No differences in the risk of other prediabetic states, such as IFG, were observed between the eating competence groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Four of the 50 mitotic entry genes (8.0%) and 8 of the 64 mitotic checkpoint genes (8.1%) tested in this study were associated with either overall or high grade breast cancer risk at the gene-level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, trabectedin dose reductions became mandatory in case of liver toxicity [increase in bilirubin >ULN; and/or alkaline phosphatase (AP) >2.5\u2009\u00d7\u2009ULN; and/or aminotransferases >2.5\u2009\u00d7\u2009ULN] between cycles that has not recovered by day 21 of the cycle4,16. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should always be interpreted with caution because sexual orientation consists of various components and can change during a person\u2019s lifetime42. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angiogenin protein became detectable in cell culture media only after at least 48 h of culturing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, the degrees to which experimental cortisol feedback-associated sex differences in unstressed humans apply to pathophysiological states (26) and/or to classical stress responses, cardiovascular diseases, diabetes, and hypertension (33) remain to be clarified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, HCV increases the risk for HCC by inducing fibrosis and, eventually, cirrhosis; while HBV can cause HCC in the absence of cirrhosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The consequences of neuronal loss in this area include severe anomia, semantic paraphasias and word comprehension impairments in the absence of equivalent perturbations in the non-verbal components of object concepts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, intraoperative remifentanil infusion during anesthesia can cause higher intensity of pain during the immediate postoperative period following thyroidectomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the performance of the model may be overly optimistic due to variable selection bias (a large number of candidate cytokines compared to the number of samples). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Importantly these relationships between objective and subjective balance problems were significantly influenced by the number of brain injuries, use of psychotropic medication, time since injury, and depression severity among participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies will be required to define the best methodology to depict the cardiac venous anatomy by CMRA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The defect is compounded by enhanced cumulative use-dependent inactivation (Fig. 7), which further reduces V1442E channel availability and may explain the abnormal CMAP decrement observed at high-frequency stimulation (Fig. 1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The opioid requirements were similar to our results, except that the opioid requirement at POD 0 was not significantly different between the 2 groups[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multiple studies found a relationship between vision problems and lower academic performance suggesting that detection of visual difficulties during childhood is of critical importance in maximizing each child's educational potential 20\u201323. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future researches including longitudinal studies should use a larger and diverse study participants utilizing a lab-based methods and using measures of emotion dysregulation and mindfulness specific for adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is no evidence for this viewpoint. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They noticed reduced LOS in all studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a study from the USA, fast food restaurant density was not associated to blood pressure among low-income housing residents in New York City; however, the study may have lacked statistical power due to its small size (N\u202f=\u202f102) (Tamura et al, 2018). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breakdown into possible outbreaks (\u226410 SNPs) revealed five possible ST410 outbreaks (PO10s) in Denmark during 2015 to mid-2017. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, it is worth mentioning that we analyzed only short-term outcomes: within 30 days after surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such an improvement has never been described around the more commonly used cemented polyethylene cups [15], metal backed cemented cups [23, 24], or cementless cups [22, 26]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, patients who underwent an RAPN had similar postoperative pain intensity to those who underwent an LPN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over the preceding decade, randomized controlled trials have standardized approaches to induction of remission and maintenance therapy.6 However, despite continuing improvement in patient outcomes with generalized disease, treatment of early systemic disease, and particularly granulomatous inflammation, confined to the respiratory and ENT tracts is not supported by the same evidence base to guide clinical practice.22 Disease relapse also remains common and PR3-ANCA antibody positivity, most often associated with GPA, and cardiac involvement are recognized as independent risk factors for relapse. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In hospitalized COVID-19 patients who develop VTE, especially in those requiring ICU admission, LMWH at therapeutic dosages may be considered the standard of care. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We validated their usefulness by using three independent datasets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, activities during a quit influenced abstinence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This methodology has been used by some investigators in other fields,19,20 but most prior HIV-1 studies have used calculated concentrations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This contrasts with a trial evaluating the effect of walnut consumption on colon carcinogenesis in mouse models which observed an increased abundance of Lachnospiraceae spp. during the walnut diet [35]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Who will benefit from prolonged pharmacological VTE prophylaxis following hospital discharge? ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding could have occurred for a number of potential reasons. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CPE is a worrisome risk in public health due to the multidrug resistance and the potential for dissemination to multiple sources, including transmission from patient to patient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This would suggest that the SLC4A1\u039427 and GYPC\u0394ex3 alleles should assort independently, if the apparent genetic load represented by SLC4A1\u039427 is not increased past a viable threshold by the addition of another significant erythrocyte membrane protein polymorphism. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we applied a bioinformatics platform, FUMA, to perform functional annotation of GWAS summary statistics reported in the largest international meta-analysis of melanoma susceptibility. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This fraction increased after adjusting for height-age, as the HGPS cohort is extremely small for age, and somatic size as well as chronologic age contribute to BP.24 These elevated BP trends would be expected in the setting of significant vascular stiffness, as prehypertensive adults display both impaired arterial functions and elevated PWV.25 The observed elevation in PWVcf without elevation of pulse pressure in this cohort may be related to overestimation of diastolic pressure by the automated cuff, altered volume status and heart rate in fasting patients, or indicate disproportionate changes in the aorta compared to the peripheral arteries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, we used the GSE6911 dataset and separately annotated four groups, as described in Results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary lutein/zeaxanthin intake and the DICER1 rs3742330 genotype were inversely associated in CRC, providing new insight into a protective effect of lutein/zeaxanthin against CRC risk in patients carrying the G allele. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The existence of such a contradiction should motivate health care professionals to inform their patients, especially women from low socioeconomic levels, about the importance of BSE. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This pharmacomorphomic approach may aid in the pharmacokinetic modeling of antimicrobials that require renal dose adjustments, and this covariate for dosing in underweight and obese patients may be superior to traditional body weight-based paradigms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, generalization of our observed single-site results to other care settings and patient populations should be done with caution. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the increasing availability of EIT to our surgical patients and its potential to improve outcomes (possibly in conjunction with intraoperative lung-protective ventilation strategies), large-sample, high-quality research is needed to evaluate the utility of real-time EIT in guiding PEEP titration after major laparoscopic abdominal surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, many crematoria staff discuss the issue of pacemakers with funeral directors, who are able to inspect the body in an attempt to prevent the cremation of pacemakers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This value is sufficiently high in order to detect the genetic association described in original study, because it exceeds 80% threshold [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study revealed associations (correlation coefficients ranging from 0.35 to 0.48; P \u2264 .05) between diffusion tensor MRI\u2013measured fractional anisotropy (FA) values at 2 weeks of age and Bayley Scales of Infant Development (BSID) scores measured at 2 years of age in healthy infants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, elevated ICA flow velocity may be due to increased flow within the brain due to collateral formation around occlusive disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With femoral plug occlusion, the use of a cement gun and stems of improved design, Harris and McGann found radiographic signs of definite femoral loosening at 6 years in 1.7% of hips [13]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The noise of an explosion may cause distress. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is similar to all participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is especially true given the high seroprevalence of C. pneumoniae infection which was corroborated in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence for considerable tradeoffs between immune function and growth among humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, this study shows that epigenetic drugs significantly upregulate BIM expression and induce cell death in ALCL cell lines and suggests that the use of epigenetic modulators may play an important role in the treatment of ALCL.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides, complications were not reported as carefully as they are now (no prospective database, no classification). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant associations between variants in or near three different genes identified in GWAS of late-onset AD and mean change in scores on tests of cognitive function over a six-year period were found for white middle-aged participants in the ARIC study (MS4A4E, CLU, and NME8), and two variants were identified in African-Americans (ZCWPW1 and CD33) in the primary analysis after adjustment for age, gender, and education. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In ST410, the introduction of blaOXA-181 on an IncX3 plasmid was predicted to have occurred around 2003 (Fig. 3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, the follow up time for BMD change in the SOF cohort was only 3.9 years on average, which might have reduced the chance to identify a significant association between BMD change and the GRS63 in this cohort. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis of rare GSVs for association with complex traits represents a complementary approach to SNP- or sequence-based methods for identifying novel loci that can account for the \u2018missing heritability\u2019 of multiple complex traits [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A questionnaire study on the awareness of early breast cancer diagnosis conducted in the Turkish city of Bursa revealed that more than half of the participants had never undergone mammography or ultrasonography examinations (Y\u0131lmaz et al, 2012). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, as this study showed, and with the exclusion of patients with prostate cancer, 1.3% of other cancer patients with known primary tumours will present with bone metastases as the first sign of metastatic disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of an ARR cutoff value with a plasma aldosterone threshold (> 416 pmol/l or > 15 ng/dl ) has been recommended by some investigations [35,36]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several GWASs have shown that some genuine susceptibility loci may not reach genome-wide significance but still demonstrate significance after results are integrated through metaanalysis from different populations with bigger sample sizes (57,58). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, many of the covariates assessed are fixed (education, gender, etc.) and therefore could not have been affected by QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our multivariable logistic regression analysis showed that the NLR may independently predict PIR, without being affected by other factors, providing evidence that it is a very useful test in predicting the prognosis of pregnancy. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In previous studies, ACE gene was found associated with rheumatic and autoimmune diseases, so that we aimed to investigate the association between ACE gene I/D polymophism and also MTHFR gene C677T mutation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The highest relative risks are in the center of the factory close to the balcony, while the lowest risks are in the areas at the sides and far end of the factory floor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with a gluten-free diet can dramatically improve bone density, especially where there is osteomalacia, but it can also lead to improvement when osteoporosis is the underlying lesion22. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Retrieval studies by Lintner et al. [20] have shown excellent biological fixation of pressfit grit-blasted titanium endoprostheses and this has been confirmed experimentally by Feighan et al. [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, further evaluation regarding whether these observed changes are preserved during longer walnut consumption is required.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Three years after dorsal instrumentation, on the other hand, two patients suffered superficial infection in the region of the scar, probably because of internal mechanical irritation of the implant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, most studies examining pharyngeal transit in aged humans used discrete, rather than self-selected, bolus sizes [9, 44]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reason for the absence of significant difference might be that the patients were generally discharged between POD 5 and POD 7 if there were no significant postoperative complications, such as postoperative bleeding[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The negative association between LUMA methylation and later age at menarche is counter-intuitive because (a) a later age at menarche is known to protect from breast cancer, and (b) lower global methylation is expected to increase genome instability and thus increase cancer risk [8], [26]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As suggested by Duckett (1992), methods of increasing tolerance should be examined systemically, on multiple levels, to more fully understand the moderators and mediators that lead to more widespread and sustainable outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the diagnosis of type 2 diabetes was assessed based on the results of one OGTT. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with the severity of the initial clinical findings, the intraoperative and postoperative complications in our patients were minor and not solely connected with the operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast with findings from high-income countries, improved safety from crime and aesthetics reduced the odds of active commuting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that for adults from multidimensionally poor households, median time to arrival at the referral hospital was approximately one day longer than for those from non-poor households. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The US Preventive Services Task Force (USPSTF) in 2011, while agreeing with the importance of vision screening in children ages 3 to 5 years of age, concluded that the current evidence was insufficient to assess the benefits and harms of vision screening in children < 3 years of age, citing costs of false-positive rates, and concluded that screening and treatment of amblyopia later in the preschool years may be as effective as screening and treatment done earlier in life 2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent studies indicate that E. coli ST410 is another successful pandemic extraintestinal pathogenic E. coli (ExPEC) lineage similar to ST131 (5, 16). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In an in vivo study, inactivating Dicer1 in a mouse model showed that it functioned as a haploinsufficient tumor suppressor in retinoblastoma and promoted hepatocarcinogenesis53,54. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Identifying the regulatory pathways through which body fat exerts a buffering effect on inflammation-related tradeoffs is an important area of future investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another possibility is that since the cognitive tests were administered to middle-aged adults whereas only 4% of those with AD are estimated to be younger than 65 years of age [Hebert et al  2003], the relationship between rs670139 and cognitive function in particular may change over the life course so that MS4A4E is beneficial in early life and has different effects at older ages. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If the CDI has not been gas calibrated, its values are inaccurate and imprecise for pH and pCO2, and thus unreliable in this situation, and the result may very well be a less than optimal blood gas management of this critical period of CPB. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, they provide evidence that individualized reading instruction is more effective in improving students\u2019 reading skills than instruction of similar quality that is not individualized; this was true at a single grade, and the findings were more consistent for first and second grade. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study found that adult patients attending Oral Health centre at International Medical University, who practised self-medication had stronger beliefs about the benefits of medicines and weaker beliefs in viewing medicines as harmful and overused. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, we will use videofluorography to test hypotheses regarding deglutition behaviors by providing treatments and examining how these treatments relate to function with the ultimate goal of translating these to human trials. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, the differential N400 elicited by the unrelated match reflects the sensitivity to the generally more robust inter-category boundaries whereas the differential N400 elicited by the related mismatch reflects the sensitivity to the more fragile intra-category boundaries where the conflict between activation and inhibition is more pronounced. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All these encouraging findings support current practices adopted within the Healthcare Surveillance Programs for HCWs and undergraduate healthcare students in several Western countries, confirming their fundamental role for the control of HBV transmission in the healthcare setting.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, we demonstrate the dissociation between systemic and local TNF pathway activation in the pathogenesis of podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Macrophages are key angiogenesis effector cells in inflammatory and tumoral angiogenesis [38], and their presence is associated with local secretion of many pro-angiogenic factors [39]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The definition of outbreaks being 10 or fewer SNP differences apart from the nearest neighbor has previously been shown plausible (9) and was thus used in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, HLA-DQ2/8 genotype was not associated with degree of inflammation in SB or rectosigmoid colon mucosa. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epidemiologic evidence suggests that erythrocyte polymorphisms have arisen in malaria endemic regions to protect an individual from severe malaria [1,2,4]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, aprotinin appears to be the most efficient drug for redLucing postoperative blood loss within 24 hours. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, the efficacy of CMRA for cardiac venous assessment specifically in patients with congestive heart failure has not yet been assessed and may prove more challenging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, the detachment of MeCP2 following treatment with deacetylating agents is also associated with histone tail reacetylation (Figure 5G), suggesting the presence of a yet unidentified acetylating complex acting in competition with MeCP2/SIN3. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In experiments conducted on animals, allergoids have accordingly induced IgG antibody titres comparable to those from native allergens [16,27]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While TNF causes NF-\u03baB activation in Caco-2 cells and macrophages, the discrepant effect of TNF on ABCA1 expression (upregulated in macrophages and downregulated in Caco-2) suggests that mechanisms other than NF-\u03baB may modulate ABCA1 expression (53). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study design and the high variability in the observed changes in the microbiome preclude any valid conclusions at this point. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In accordance with previous literature, patients of our study reported expected toxicities of treatment with trabectedin. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "E2 modulates mean, pulsatile, basal, and entropic measures of ACTH secretion under both continuous and pulsatile cortisol feedback. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of pistachios was much stronger than that of almonds and resulted in an increase in potentially beneficial butyrate-producing bacteria in the phylum Firmicutes [42]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is noteworthy that our study found the married or widowed/divorced are independent risk factors for hypertension, contributing 2 and 3 points to the risk score, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As we have reported previously, in our institutional experience, we identified a trend to improve assessment and documentation of the characteristics of pain, as well as intensity and location of pain (Oakes, Anghelescu, Windsor, & Barnhill, 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the power limitations of the insoles, some subjects could not perceive the vibration at its maximum amplitude for particular threshold configurations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, we identify NFATc1 activation as the link between TNF and ABCA1 repression, thus shedding new light on the mechanism of TNF-induced local injury in glomerular diseases as well as other chronic inflammatory conditions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although arterial intima-media density has been correlated with cardiovascular risk factors and carotid plaque echogenicity in elderly adults14, the striking degree of adventitial abnormalities observed in this study have not yet been evaluated in aging and should be the subject of future studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, there is some preliminary evidence that especially improving contextual skills and positive eating attitudes in weight management interventions are particularly helpful to losing weight [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important for nurses to be aware of rescue analgesia strategies, such as PCA analgesia to protect against breakthrough pain on ambulation, end-of-dose failure on controlled-release opioids, or spontaneous pain with no obvious pathology (Chiaretti & Langer, 2005). ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During these periods, drivers are confined to their trucks, and workplace policies often prohibit them from leaving certain pre-defined areas for their own safety.3 Not surprisingly, drivers do not consider transport industry workplaces to be conducive to physical activity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "no discussion section", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After changes in the structure of our university hospital (a new laparoscopic oncological surgery unit was created), we started performing gastric cancer surgery laparoscopically. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is also possible that age at menarche is an indirect indicator of other macroscopic changes that may impact on DNA methylation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it is not possible to exclude an unknown carrier of the clone, nor an unregistered travel link for patients P2 to P9, whereas patient P1, with the isolate from 2015 (AMA1167), had traveled to Egypt prior to isolation of AMA1167 (10). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, mutations at the arginine residues of IV/S4 that cause myotonia and slow the rate of inactivation (31) are presumably because of an effect on the rate of a conformational change rather than on inducing bias. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering that ARV treatment is associated with better QoL, the above difference between the two populations might have somehow influenced our results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast to the findings of LUMA, genome wide methylation in this second dataset did not significantly differ between subjects in different menarcheal age groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, endogenous oestrogen exposure is a strong candidate for epigenetic changes since an earlier age at menarche exposes a woman to a greater cumulative amount of endogenous oestrogens over her lifetime, and there have been reports which show that oestrogen impacts on DNA methylation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In diseased cardiovascular tissue and plaque, both animal and human studies have supported duplex ultrasound as a useful tool for detecting tissue pathology with dysregulated extracellular matrix through increased echogenicity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to note that a maximal exercise treadmill test requires the pulmonary system to perform at a peak level; thus, this test allows the assessment of pulmonary function beyond resting levels. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the reality is that we are only just beginning to answer this question. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The design features of this first confirmatory trial with Hypericum extract in long-term prophylaxis of mild to moderate major depression are in accordance with the demands of current consensus statements and guidance (Center for Drug Evaluation and Research, 1978; Kasper et al, 1997; Committee for Proprietary Medical Products, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While we recognize that the small sample size of our study means that the findings warrant confirmation in larger cohorts, we conclude that the immunophenotypic landscape in CVID and other PAD comprises a varied and overlapping spectrum in which asymptomatic relatives show an intermediate immunophenotype, supporting the notion of a complex etiological basis of PAD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, age at menarche was negatively associated with LUMA genome wide methylation in a statistically significant manner. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies showed inconsistent results for the association between ARV treatment and QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AKT participates in cellular survival and protein\\[citation\\]\\. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, previous studies provided data that daily salt intake of local population is about 12.4\u201316.1\u200ag [30,31]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, the host response and the immune mechanisms require fine balances between pro- and anti-inflammatory components and between recruitment and death of immunocompetent cells, involving lymphocytes and monocytes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the current study indicate that there are unique associations of emotion regulation, dispositional mindfulness, and social support with adolescents\u2019 social anxiety; therefore improving these constructs may be helpful for adolescents who are at risk of, or are suffering from, higher symptoms of social anxiety. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Differences between our findings and those of other research groups may have been due to technical differences in analysis methods or differences in laboratory technique. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this view, this region may harbor susceptibility loci for clinical features of AD, or its risk factors, but is protective for early change in memory. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of patients attending public sector services are required to pay for medicines from private vendors due to depletion of essential drug stocks, and many experience pressure to pay unofficial fees to members of staff [28, 42\u201344]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis of CD4 cell count and QoL was suggestive of an association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sometimes, pacemaker remains are found. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, a possible contribution of macrophages to significant angiogenin synthesis in specific articular diseases remains to be demonstrated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In animal models, the ratio of Bacteroidetes and Firmicutes is altered in response to dietary changes [18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Those with normal IMT had the same increased echogenicity as those with widened IMT within both the intima-media and within plaques. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More specifically it was shown that oestrogen receptor (ER) positive breast tumour tissues have differential methylation at several CpG loci compared to ER negative tumours [24], [31] and oestrogen induced breast tumours have differential DNA methylation patterns in ACI rat mammary gland tissue [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baumgartner et al. have reported a 98.9% survival rate in their series of 533 primary Alloclassic THRs at 6 to 7 years [1]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, we analyzed performance not only in terms of mean group differences in raw scores but also using normative data from non-TBI persons to determine the degree of impairment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study showed that individuals younger than 40 years of age and those with lower education level are at higher risk of having poorer QoL and health perception, while individuals with higher CD4 levels and those receiving ARV treatment tend to have better QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The slowing of reaction times during trials where the correct choice and the foil both belonged to the same category offered a measure of the magnitude of taxonomic interference. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall findings shows that mean social anxiety score among Nepalese adolescent students in the current study were 2.31. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, we instituted hemoconcentration and postoperative reinfusion of blood drained from the operative field and the extracorporeal circuit. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Spirometry is primarily performed at rest and is largely effort dependent. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The tooth size discrepancy in Class III cases was the most prevalent. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of severe complications and paucity of systematic surveillance data reinforce the importance of continuing and improving surveillance in this area and implementing recent enterovirus diagnostic guidance for systematic surveillance of non-polio enterovirus types [5]. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Understanding the intersections and distinctions between HGPS and normal aging can inform both fields of study, and help us to interpret the clinical influence that progerin may have after a lifetime of low level accumulation in aging4, 26, 27, versus its intense production in children with HGPS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was shown that these elements shorten LOS, and their simultaneous use has a synergistic effect. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The psychological nature of such cached values can be related to either Pavlovian (as used in [12]) or instrumental (as used in [11]) processes in the brain, depending on whether cached values are coded for state or for state-action pairs, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, the life satisfaction ratings of patients who reported a very central religious meaning system were not negatively influenced by higher levels of pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following discharge from hospital, prolonged pharmacological VTE prophylaxis in the ambulatory setting is reasonable in patients with persistent immobility, high inflammatory activity, and/or additional risk factors (as mentioned above). ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We had anticipated that the inclusion of sensitive neuropsychological measures as secondary outcomes in this clinical trial would demonstrate a benefit in specific cognitive domains such as memory and executive functioning beyond the more global abilities measured by the GOSE. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis per cycle performed in patients treated with the monotherapy regimen in our study showed grade 3 elevations of AST and ALT in 12% and 20% of cycles, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "18 and 19) but not others (e.g., refs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such syndromes respond incompletely to opioids (Fields, 1988; Portenoy, Foley, & Inturrisi, 1990; Rowbotham et al., 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These previous findings enhance the biological plausibility that this SNP in STAT4 may play an important role in the liver fibrosis progression, although the molecular mechanism remains uncertain and further functional studies are required. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings may be further validated by longer term follow-up and cognitive outcome assessments that are not possible at age 2 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we examined the role of inflammatory mediators and apoptotic mechanisms in the pathophysiology of CRS Type 5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Six months after the operation we found no significant differences in the results of the self-assessment questionnaires between groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The studies by Bock and colleagues indicate that only short durations of maternal separation stress are necessary to induce dendritic and spine alterations in sensory cortex (Bock et al, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since modern multimodal care involves all medical staff members (surgeons, anesthetists, nurses, dieticians, physiotherapists), the whole team should establish compliance with the protocol. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Persistent, continuous pain is best managed with long-acting opioids. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results are particularly concordant with a study on post-stroke patients that attributed a specific and critical role of the left anterior temporal lobe in mediating fine-grained taxonomic distinctions during the retrieval of object names and which showed that this role was not dependent on amodal pre-lexical conceptualization impairments (Schwartz et al, 2009; Walker et al, 2011). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The major strengths of our study are the prospective nature and the longitudinal design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The accuracy and precision of the calibrated CDI estimates, gas or ABL calibration, for pH, pCO2, and pO2 were not significantly different from the ABL values, and thus the calibrated CDI can be a valuable tool for the perfusionist in maintaining a stable and physiologically correct acid-base balance during CPB. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has several limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two case reports implicate straw: a physician who contracted Q fever after clearing out straw and rubble from his new moorland home (26) and a businessman who was cleaning out a barn that had been used for keeping livestock 10 years previously but had not been properly cleaned since (24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, craving failed to increase in about half of the prior cannabis abstinence studies (Allsop et al, 2012), and this also often occurred in tobacco abstinence studies (Shiffman, West, & Gilbert, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, some positive individuals were subsequently recorded as being negative for cutaneous lesions, suggesting that lesions may be a transient stage in advanced infections. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the patient in the tranexa.mic acid group who required reoperation to establish hemiiostasis, no surgical bleeding w.as found and only clots were removed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, late menarche and early menopause decrease the risk of developing breast cancer (Key et al, 2001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since knockdown of ABCA1 did not lead to podocyte injury in vitro (Figure 5) and in vivo (Supplemental Figure 14), it is likely that a second hit is required to cause podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This property, which was also observed for the sitting position here, may likely be explained by lower amplitudes of breathing-related diaphragmatic motion, as already documented for upright versus supine positions in previous MRI and ultrasound studies (25,26). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were some exceptions with 2 individuals being positive for 6 months. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Today, most pacemakers are driven by the lithium/iodine-PVP energy source. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The difference was, however, less than 1 point. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The biker position was additionally associated with a trend toward a lower rate of anteroseptal and apical defects, as compared with the supine position, together with a higher normal segmental uptake in the proximal and median portion of the anterior wall (segments 1 and 7 in Fig. 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our response criterion for acute treatment, which also serves as an eligibility criterion for continuation treatment, combines well-defined clinical improvement and a halving of the initial HAMD total score. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Western region of Saudi Arabia, very few studies were conducted to assess dental arch forms and tooth mass ratio of lower to upper dentitions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike the previous studies, the sample of the present study was collected from different private practices in Jeddah, Saudi Arabia to be representative for the patients seeking treatment in that city. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, patients presenting at oral health outreach programs were recruited in the study conducted by Simon et al, [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Figure 4 highlights the quantitative power of analytic morphomics over standard measures of height, weight, and BMI when evaluating like-sized individuals with different body compositions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that populations bearing a heavy burden of health disadvantage may require enhancing intervention dose. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvement of oxygen supply is one of the key concepts in reducing mortality and the rate of complications in septic patients24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high level of sensitivity, confidence and self-efficacy and health motivation, and low level of obstacle perception of the participants who had breast cancer in their families indicates that these women are more aware of breast cancer risks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis of metabolic fingerprints might be useful to understand how microbial structures are influenced by regular walnut consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, identification of developmental BMIz trajectories in the first 2 years may be helpful in identifying high-risk groups. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Half of the women approached were not eligible for inclusion in the cohort, and we had no wish to generalize our findings to ineligible women and children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cross-sectional analysis of 401,917 UK Biobank participants revealed a weak inverse association between distance from a fast-food outlet and waist circumference and BMI (AlHasan and Eberth, 2016). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adequate treatment of recurrent depression should provide symptom relief for the current episode, protect against relapse and prevent recurrence (for example, Montgomery, 1994; Kasper et al, 1997; Keller, 1999; Keller and Boland, 1998). ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We addressed the cellular origin of angiogenin in SF. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the authors noted that these harmful effects depended on the degree of hyperoxia and were more prominent in certain subgroups, a high intraoperative FiO2 might be considered unnecessary and even disadvantageous. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This position is seemingly more comfortable than the prone position, with the patient\u2019s shoulders being less stretched back and breathing less affected by lung compression due to thoracic weight. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, for our experiments, we used human renal tubular cell line immortalized by Adeno5/SV40 virus. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recently Linde and Mulrow (2000) have suggested to compare the antidepressant efficacy of Hypericum extract with standard antidepressants in well defined groups of patients over longer periods of observation as well as to study different extracts and doses (for a discussion of therapeutic alternatives to Hypericum extract in long-term prophylaxis of depression, see Winkler et al, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on this result, we might hypothesize that apoptosis and organ damage were induced by these inflammatory mediators. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In one of our patients, the distal screw was observed to have broken away from an osteoporotic thoracic vertebral body 3 months after the operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It would be interesting to determine whether TNF-induced podocyte injury is linked to the formation of cholesterol crystals, a phenomenon that was recently shown to be prevented by HPBCD in macrophages in the setting of atherosclerosis (57). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a setting where hospital admissions pose considerable financial strain, and where in-patient demand exceeds provision, recommendations that leads to too many hospital admissions could be as dangerous as those that lead to too few [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the principal risk factors for fracture at any given skeletal site is the bone mineral density at that site,13 and it is the occurrence of potentially debilitating fractures resulting from minor injury in patients with coeliac disease that has led to concern over the eVect of coeliac disease on bone density at sites of fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, CEACAM1 plays an important role in the change from endothelial cells to an angiogenic phenotype during prostate cancer development,24 and BRCA1 is regulated by the androgen receptor and often mutates in prostate tumors 25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We liimited homiiologous blood transfuisions to patients with evidence of hypovolemia in the intensive care unit ancd wvith hemoglobin values less than 8.5 g/dL, to patients with asthenia and tachycardia after mobilization in the ward, or to patients with severe anemia (hemoglobin <7 g/dL). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research could examine the effects of antiparkinsonian medications using this model, or the effect of aging combined with parkinsonian models. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gaining a clear mechanistic understanding on how dysfunction of heart can lead to kidney organ failure is critical to identify potential treatment targets and disease management strategies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the patients whose disease was mainly localized to one lung and who could tolerate pulmonary resection were considered for surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "And \u201cIn this house we don\u2019t see each other as different colors, we are a family\u201d Theories of psychological change may be useful to understand the ways in which the Oxford House self-help process may facilitate increases in diversity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, high SF angiogenin levels were found in patients with acute crystal-induced inflammation, namely, gout attacks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, although subjects carrying a highly-penetrant causative variant might na\u00efvely be expected to display the phenotype regardless of ethnicity, geographical origin or environmental exposure, we have very little information on the potential for cohort-specific modifiers that can confound that expectation, or on differences in the frequencies or characteristics of rare variants between different populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PWV is inversely related to arterial wall distensibility, and serves as the gold standard for measures of arterial stiffness 22. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, we discovered abnormally echodense vascular walls in the HGPS cohort. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigation into the role of oestrogen on repetitive element methylation is, therefore, warranted. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, even evidence-based and culturally adapted complex interventions may be insufficient for populations bearing a heavy burden of health disadvantage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A conspicuous feature, however, was superficial wound infection, caused by internal mechanical irritation of the dorsal instruments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the fact that this approach to gastric cancer patients is rather new, more studies are required to further increase the validity of this concept.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been reported that blocking antibodies have a protective activity by inhibiting immediate as well as late inflammatory responses and long-term ameliorating activity on the allergic immune response by antagonizing the underlying IgE production [29]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, environmental factors can affect the onset of CHD and AKT1 rs1130214, rs3803300 polymorphisms involve in the generation and development of CHD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study of Dahlui et al, (2011) revealed that university students gathered most of their information from family and friends, and the internet was the second tool they used for acquiring information. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lack of prior HCV diagnostic information could lead to an underestimation of HCV screening rates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some recent studies performed in this occupational setting in our country, among both HCWs and HCSs trained at teaching hospitals, reported similar encouraging evidences 10,20. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the Hang et al.\u2019s data, they suggested that ACE I/D gene polymorphism I allele is a risk factor for early onset, severe form of primary knee osteoarthritis [8]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many studies of cannabis abstinence or reduction focus on a single attempt to stop or reduce cannabis use, and many do not follow participants after they relapse. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All of the DSM 5 cannabis withdrawal symptoms we tested changed as expected on abstinence days even though many attempts were short-lived. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the patients\u2019 perception\u2014and hence response to the question\u2014of limping may not match an objective measurement of limping. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a consequence, the presented effect sizes for MrOS Sweden might be slightly overestimated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first published report of the frequency and consequences of pacemaker explosions in crematoria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In most studies, N-acetylcysteine was administered orally at least 24\u200ah before CM. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, adjuvant IFN-alpha for the treatment of high-risk melanoma significantly reduces the risk of relapse and has been shown to improve melanoma patient survival (45,46). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A prospective randomized study is needed to clarify this point. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, our results suggest that ANP-mediated inhibition of metastasis occurs through inhibition of the inflammatory response. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, ANP is an endogenous and physiological peptide and has been proved not to cause severe adverse effects when used in patients with heart failure (35). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, this study adds to the growing knowledge about seminal plasma cytokines and HIV-1 RNA levels in untreated men with chronic infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was only one child at risk for strabismic amblyopia with an abnormal reading for gaze asymmetry. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Terry et al. [18] found that a later age at menarche was associated with higher genomic global methylation later on in adulthood, but DNA methylation was only assessed in 92 individuals and the authors used a different technique for measuring global methylation ([3H]-methyl acceptance assay). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, during a complex tongue protrusion test, average, but not maximal force generation was affected by 6-OHDA lesions [69]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maintenance of a stable high BMIz trajectory or accelerated BMIz gain was strongly associated with higher adiposity and increased obesity risk, while maintenance of a stable low BMIz trajectory protected against increased adiposity and obesity risk at 5 years, in line with earlier findings17, 18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Loss of fornix white matter has shown to be a strong predictor of cognitive impairment in the elderly (26). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The data here are likely to under-represent the true circulation of EV-D68 and other enteroviruses in Wales, as most patients with acute respiratory symptoms, will not undergo testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as antibody levels of the latter two were still detectable, it is advisable for clinical laboratories to perform chlamydial antibodies by MIF as a panel, rather than offer them separately. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elamaran [23] used a quantitative RT-PCR assay to analyze the effects of O2 concentration (5% vs. 20%) on the relative abundance of gene transcripts in buffalo embryos produced in vitro and noted an increased expression of anti-apoptotic genes BCL-2 and MCL-1 and a decrease in the expression of pro-apoptotic genes BAX and BID in pre-implantation stage if culturing under 5% oxygen concentration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the strong biological rationale used to select these genes suggests that the observed associations, while not statistically significant, may be genuine. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It seems that higher education provides more opportunities to get a better job and monetary benefit compare to lower education in Korea. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consequently, contaminated dust may have been dispersed or cleaned up in the interim. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, our study suggests that self-efficacy and physiological challenges may limit the effectiveness of these strategies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because most of these discordant cases had serology and direct detection testing drawn at or around the same time point (Table \u200b(Table2),2), this scenario is not unlikely. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poloma and Pendleton (1991), for example, pointed to the different types of prayer and state that these differences determine the experiential consequences of prayer such as general well-being. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overhanging balcony may have sheltered employees at some of the machines from any contaminated dust falling from above. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, as participants beliefs in viewing medicines in general as harmful and being overused become stronger, they take a lower total weekly dose of analgesic. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other studies have suggested that lutein/zeaxanthin bioavailability affects carcinogenesis via its antioxidant properties by inducing apoptosis and proliferation, preventing oxygen radicals, regulating gene expression, and activating the immune response6,12,21,40. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Opioid tolerance is a progressive decline in response to opioids, which increases demand. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Utilization of intravascular contrast agent may allow for a longer time window for contrast-enhanced imaging, as well as repeat of measurement if necessary. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may also be that younger patients need further persuasion by multiple home BP measurements to be willing to accept the diagnosis of hypertension and need for treatment. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trends in the past decades show a rapid shift towards an earlier age at menarche and this is more pronounced in developed countries [33]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pattern may also be important since no clinical investigations of negative feedback have yet attempted to emulate a physiological train of cortisol pulses (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, a randomized study with 3-month follow-up showed this tendency in both surgeon-reported and patient-reported outcomes (Witzleb et al 2009), although the differences were not statistically signifi cant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "de los Santos et al. [18] in an ovum donation cycles found that reduced oxygen tension improved embryo quality but not clinical pregnancy rates in a cleavage-transfer program. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that circulating TNF in DKD but not in FSGS may at least in part contribute to increased glomerular TNF expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The experimental model used here does not discriminate between these two principal possibilities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While SOAT1 activity is likely to be tightly regulated to maintain cholesterol homeostasis in normal podocytes, the possibility that altered SOAT1 activity contributes to podocyte injury in disease conditions warrants further investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unfortunately, the CKD patients were recommended the use of aldosterone antagonists [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The St Jude Pharmacological Guidelines for Pain Management indicate a starting dose of 0.1 mg/kg orally at bedtime, with the option of doubling the dose every 3 to 5 days up to a maximum dose of 1 mg/kg. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, we will follow the current population of this study for several years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In recognition of a body fat-dependent relationship with growth, we follow others (50) in proposing that recurrent inflammation during childhood may have lifetime developmental effects on metabolism, energy use, and health. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These issues should be addressed before making any fi rm conclusion about the superiority of one approach over the other. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More research is needed to understand and assess additional factors (e.g., socio-economic status, car ownership, commuting patterns, and travel distances) and their relationship with active commuting across larger geographical areas and over extended periods of time in LMIC contexts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As new analgesic strategies were incorporated, stages in the evolution of pain management during the 26-year study period were defined, as indicated by the timeline represented in Figure 1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, a high-fat Western-type diet in mice resulted in an increased abundance of Firmicutes and a decrease in Bacteroidetes [19,24,25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings highlight the importance of educational interventions as well as the importance of adherence to ARV treatment in HIV patients to improve their general QoL. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite our efforts to address community health priorities, deploy evidence-based interventions grounded in behavioral theory and research gold standards, we observed few statistically significant changes in increasing PA or f/v intake. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some explanations of this discrepancy in NGAL role in different studies may lie in the utilization of different sample types for NGAL measurements (urine and plasma) with probably different pathophysiological mechanisms and different methods for NGAL detection with different sensibility and specificity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A 17-item HAMD total score of 16, one of our relapse/recurrence criteria, indicates mild depression requiring treatment and has thus been used as an entry criterion in many clinical trials (for example Reimherr et al, 1998; Kalb et al, 2001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, the diarrhea in IBS-D patients may be the result of other factors, such as alterations in gut permeability, inflammation, or microbial flora. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been pointed out that reducing DUP through early detection may be possible from a service systems perspective (citation, 1999), and our data support this notion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unfortunately, we observed no significant evidence of association between SNPs identified by HCV-related HCC GWAS and the risk of HBV-related LC, which also failed to be replicated in our own HBV-related HCC GWAS population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in other studies, childbearing history and even mother's pregnant age also participate in CHD occurrence[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The placentas of common rodents can also contain large numbers of C. burnetii sporelike forms (21) and could contaminate straw. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, parents who are highly educated are more likely to recognize the symptoms of atopic dermatitis and to see doctors than are parents with less education [38]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is noteworthy, that females are also less affected behaviorally in our stress model (see: Supplemental Fig. 1 and Hohmann et al 2012a). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We integrated SNPs at the level of whole genes and performed a gene-based analysis with FUMA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, with the exception of only one individual, falls were not reported as an issue, but our cohort did report difficulty with high level physical daily life activities and frustration related to their balance problems, which may have a negative impact on their quality of life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it could be argued that, after the initial diagnosis and treatment, follow-up screening for all cancer patients without evidence of bone metastases and in the absence of skeletal pain should include a complete clinical and laboratory examination including tumour markers. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the cortical changes, resulting from the stress exposure, are subject to modification by behavioral exposure in young adulthood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although three previous studies5,10,25 have examined differences in MMPI-2 scores according to gender, age, and sexual orientation, to our knowledge, the present study was the first to report MMPI-2 scores for a large sample of French transsexuals according to their biological sex, age, hormonal therapy status, onset age, and sexual orientation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, because our analysis was based on a relatively small number of genes, a larger study will be needed to identify the best predictors of disease outcome overall.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent report suggested that stance time variability in a similar cohort of 379 elderly subjects was a significant predictor of mobility disability [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, there was no significant differences between the means of male and female groups for the overall and anterior Bolton\u2019s ratios. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We, herein, demonstrate that the GRS63 is associated with BMD, but not BMD change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With 14 subgroup interaction tests, some of our findings may represent chance findings, so our results should be interpreted cautiously and considered hypothesis-generating. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diet assessment of each participant confirmed that all the patients were ingesting gluten in the weeks prior to entry to the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that the associations of eating competence with metabolic risk factors of type 2 diabetes are not fully explained by the difference in BMI between ECPs and NECPs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The coalescence analysis (Fig. 2 and \u200band3)3) on the global collection of 127 ST410 isolates indicated a most recent common ancestor approximately 214 years ago (the early 1800s), with confidence intervals stretching 30 years backward and forward. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C. burnetii sporelike forms are resilient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on these preliminary results, we may speculate that CRS Type 5 could result from an uncontrolled and deregulated inflammatory response. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The temporal distribution of EV-D68 activity in Wales is broadly similar to reports from outbreaks previously described elsewhere, including emerging reports of EV-D68 activity and AFM in 2018 from the US [7,8]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It would be interesting to follow IPH and IgGSD patients as well as AFM over time (especially young individuals), to see whether their immunophenotype approaches that of patients with CVID. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is likely that such under-sampling would be non-differential, affecting poor and non-poor groups equally; this would bias the results toward the null hypothesis, and lead to a more conservative estimate of difference between poor and non-poor populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our preliminary analysis of the relationship of both GYPC\u0394ex3 and SLC4A1\u039427 to malaria susceptibility in Liksul revealed no association with the prevalence of P. falciparum or P. vivax prevalence or parasite density. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the authors, these differences cannot be entirely explained by age.18 Our study has several limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the most rigorous study of non-treatment seekers, alcohol substantially increased (+8 standard drinks/week) as did tobacco use (+2 cigs/day) during abstinence (Allsop et al, 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The range of prevalence of cutaneous lesions observed is comparable to that reported by Cavanagh et al (2002) in the same area, where overall prevalence of external signs was approximately 2%, but reached levels of 8% in April. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most teachers in this study, when given training and support, were able to provide more effective literacy or mathematics instruction in line with their treatment assignment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Graded Object Association Task confirmed the presence of an abnormally intense interference effect in the PPA group and also demonstrated its selectivity for verbal rather than non-verbal associations of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A longer learning curve and increased operative time are among the main disadvantages of minimally invasive access to gastric cancer surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By implication, teachers who are generally less effective can learn to improve their classroom practices in ways that improve their students\u2019 test scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accurate gene regulation is a safeguard in heart formation, furthermore, most of CHD patients occur in embryonic period, which may be caused by the structure and function of genes regulating the differentiation and morphogenesis of myocardial cells.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The purpose of this study was to develop assays of deglutition behavior in rats using videofluorography and to determine if signs of dysphagia would be evident by videofluorography in aged and parkinsonian rats. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Investigating the process used to make the straw board indicated that the low pressures and temperatures involved would not kill any fungal spores present in the straw. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A large majority of the prior evidence on built environment correlates of active commuting was limited to high-income countries, and more recently, some LMICs in South America and Africa [56,57]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rats were separated from the dam three times daily, for 15 minutes each, between postnatal days (PND) 4 and weaning at PND 21. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous epidemiological studies have shown conflicting data regarding the association between lutein/zeaxanthin intake and CRC risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings strongly support the recommendation by the regulatory health Agencies to screen and booster susceptible individuals belonging to high-risk groups, such as professionals employed in health care services. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children 5 years or older who are expected to experience moderate to severe pain for at least 24 hours can benefit from PCA analgesia; it can also be safely used for younger children with the assistance of nurses or family members educated on the use of PCA (Anghelescu, Burgoyne, Oakes, & Wallace, 2005; Chiaretti & Langer, 2005; Kost-Byerly, 2002; Wuhrman et al., 2007). ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with previous reports, SLC4A1\u039427 was rare in the Wosera and no SLC4A1\u039427 homozygous individuals were identified in either population [6,20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the magnitude of morphological changes we describe may be unexpectedly large, it is not out of proportion with other studies we have conducted using the same morphometric approach in Balb/CbyJ mice (Hohmann & Berger-Sweeney, 1998; Hohmann et al, 2000; Krasnova et al, 2007). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A patient navigator-based intervention to promote engagement in smoking cessation treatment was feasible and acceptable to low-income and minority patients in a primary care setting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the experience of the surgical team in perioperative care based on ERAS protocol principles is mandatory to provide high compliance with the protocol. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More convincing data are needed to provide tailored oxygen targets for clinicians. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research should focus on more targeted, longitudinal studies, and other methods including case control studies and trials into specific interventions to see if they are useful for increasing emotion dysregulation and dispositional mindfulness in this vulnerable population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, when comparing the frequency of the DICER1 rs3742330 allele, carrying a G allele (AG\u2009+\u2009GG) was significantly associated with a decreased risk of CRC compared with AA homozygous carriers via a dominant model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, our results suggest that DNA methylation changes, particularly in repetitive elements, may be associated with menarcheal age. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As with aging, this implies that visible plaque occurs later in disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent investigations of pulsatile versus continuous glucocorticoid effects upon the expression of central-nervous-system genes (15) provide a possible experimental framework for studying these questions in animal models as well.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus the present inferences require confirmation in larger cohorts sampled over 24 h. Additionally, the conclusions of this study apply to healthy older adults and not necessarily to children, adolescents, premenopausal women, chronically stressed individuals, or ill patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caspase-8 is an intracellular cysteine protease which plays a central role in the initiation of apoptotic cascades and caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and ATP. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas there were no differences in TJ protein mRNA expression according to HLA type in our current study, ZO-1 protein expression data suggest that HLA type may influence alterations in intestinal permeability to sugars, but larger studies are warranted. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daily consumption of 43 g walnuts resulted in significant changes in composition and diversity in the gut microbiome by enhancing probiotic- and butyric acid-producing species in healthy individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Suboptimal in vitro culture conditions, specifically exposure to high oxygen concentrations have been associated with increased reactive oxygen species (ROS) generation and compromised developmental ability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The FtMs, in comparison with the MtFs, seem to pass more easily for the opposite gender25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As previously described for endothelial cells [35], angiogenin release by synovial fibroblasts increased with cell density, suggesting that excessive proliferation of synovial cells in inflammatory joint disease may result in accumulation of the angiogenic protein. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be expected as most individual SNPs included in the GRS63 were significantly associated with BMD in both sexes (15). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In his preface to the Dictionary, Johnson felt compelled to write, \u2018I am not yet so lost in lexicography as to forget that words are the daughters of earth, and that things are the sons of heaven\u2019 (Johnson, 1755). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In smoking population, we gained the similar conclusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the mucosal barrier data are consistent with the hypothesis that gluten sensitivity (without celiac disease) may represent a separate entity in the spectrum of IBS-D patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prospective studies of Berrino et al (1996) (24 cases) and Dorgan et al (1996) (71 cases) both reported a significant association between breast cancer risk and total testosterone concentration, quoting adjusted odds ratios of 7.0 and 6.2, respectively, for the top category of the concentration distribution. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By contrast, we chose a HAMD total score of 20 for inclusion into acute treatment in order to obtain a patient sample with a higher degree of pathology so that a sufficient number of \u2018terminal events\u2019 during the continuation and maintenance phases can be expected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, pneumoperitoneum had a considerate influence on the change of ventilation distributions, and the 8 or 10-cm H2O PEEP was not sufficient to prevent a secondary ventral shift in all patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigation regarding how lutein/zeaxanthin impacts miRNA associated DICER1 expression levels and miRNA processing machinery relative to CRC risk is needed to understand the associated molecular mechanisms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this outbreak is the first where straw board was suggested as a possible source of Q fever. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epidural opioid analgesia targets drug delivery to the site of pain, thus requiring a lower dose of opioid, and exerts a synergistic effect with local anesthetics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results suggest that the majority of Georgian HIV-infected patients had poor general QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, performance in at least one test of non-verbal object knowledge exceeded the 90% level of accuracy in 5 of 11 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "27 To differentiate the changes of hemostatic parameters observed in COVID-19 patients from those observed in patients with DIC and consumptive coagulopathy of other etiologies, the term pulmonary intravascular coagulopathy (PIC) has been introduced. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high rate of recurrence of these deletions likely contributed to their early discovery and replication using these methods. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We may build appropriate model for assessing the risk of hypertension and for identifying high-risk factors, which could early screen the high-risk groups of hypertension and provide the basis for the developing interventions for hypertension. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From the global analysis, the close genetic relationship between four ST410 isolates isolated in the United Kingdom and the genomes from Danish ST410 isolates from PO10-3 could indicate a similar introduction to the United Kingdom; however, two of the patients from the United Kingdom reported no travel prior to hospitalization, and for the remaining two, travel information was unavailable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The image quality of cardiac veins can be improved as a result. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measuring the NLR in a pregnant woman experiencing preterm labor or pPROM may reduce the frequency of unnecessary amniocentesis to as low a level as possible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we found that angiogenin was present at similar concentrations in plasma from both healthy subjects and rheumatic patients in the same range as those previously reported [35,37]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, children with greater body fat were able to completely avoid the detrimental effects of acute inflammation on 1-wk growth, suggesting that childhood adipose energy reserves play a critical role in buffering immune-related tradeoffs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results indicated that for religious affiliated patients high levels of prayer were related with lower levels of pain severity whereas this is not the case for religious non affiliated patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of pistachio consumption on gut microbiota composition was again much stronger compared to that of almond consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In all patients with confirmed SARS-CoV-2 infection, the indication for pharmacological VTE prophylaxis with LMWH (or alternatively with fondaparinux) should be evaluated on a regular and permissive basis, regardless of the need for hospitalization. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For instance, Cushieri et al. noticed a complication rate of 46% [2]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding is inconsistent with prior literature that suggests a stronger relationship between body size and volume of distribution, including a study of over 2,000 individuals with diverse body sizes, which found an R2 of 0.2 between volume of distribution and lean body weight (1, 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies using navigator-gated, whole-heart SSFP CMRA demonstrate that MR can visualize the anatomy of the cardiac venous system at 1.5T [6\u201310]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is lower than those obtained in 2 recent Italian studies that showed a proportion of seroprotected subjects vaccinated in infancy and adolescence of nearly 77% and 88% respectively, after similar period since HBV vaccination.10,20 However, previous studies have reported that 40\u201360% of subjects vaccinated in infancy had a seroprotective ant-HBs level after 15\u201320 y since vaccination, meanwhile the prevalence rise to 85\u201390% in those vaccinated in adolescence after 10 y since vaccination.21,22 The immune response in subjects vaccinated during infancy showed a physiological decline in terms of anti-HBsAg antibody concentrations, a well known phenomenon already reported.18 The antibody concentations decline observed in our study didn't impact on the protection of vaccinees against HBV, thanks to the immunological memory acquiered with the infant immunization course. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of these components can only be addressed by a different study design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is similar to that of Australian study where the mean social anxiety score was 2.22 [5]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Research drawing attention to the socioeconomic factors shaping the biobehavioral processes of energy balance holds further relevance for vulnerable populations\u2014urging attention to the relationships between inequality and physiology. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "STAT4 is a transcription factor belonging to STAT family23, important members of Janus Kinase (JAK)-STAT pathway, that is required for the development of Th1 cells from na\u00efve CD4+ T cells24 and interferon-\u03b3 (IFN-\u03b3) production in response to interleukin-12 (IL12)25 and type I interferon (IFN-\u03b1 or IFN-\u03b2)26. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we consider that the statistically non-signifi cant between-group difference of ~3 HOOS points in all the HOOS subscales included, in favor of PA, was not clinically relevant\u2014based upon current evidence (Frobell et al 2008, Roos 2012, Villadsen et al 2014, Kise et al 2015, Kise et al 2016). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, we could not control for the dose of remifentanil. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we informed the patients and primary care physicians of the results and assigned patients with CKD to a lower BP goal, there was no system-wide effort targeting BP control in patients with CKD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Osteomalacia, but without the additional factor of secondary hyperparathyroidism, was also present in cases 2 and 3. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, it is likely that EV-D68 in the community was mostly undetected, due to potential under-ascertainment of mild cases and under-sampling. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Study Limitations The response time from when the blood comes into contact with the CDI sensor and until the results are displayed on the screen is less than 1 minute, and the display of the CDI is updated every 6 seconds. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The remaining eight patients also displayed major word association and comprehension impairments as revealed by the PPVT, a result that agrees with a previous study on a more heterogeneous group of PPA patients with and without anterior temporal atrophy, where PPVT performance was most strongly correlated with atrophy of the left anterior temporal lobe (Rogalski et al, 2011). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As demonstrated in this study and described in our previous studies, maternal blood NLR may be considered the most useful, noninvasive prenatal diagnostic method currently known. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, certain types of deglutitive deficits found in the aging and parkinsonian rats may parallel deficits found in the human. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, the participants were initially selected based on their increased risk for type 2 diabetes, their average BMI was high, and men were underrepresented, which limits the generalizability of the results to general population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, screening for this secondary hypertension is widespread. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the doctor signing the form may mistakenly report that there is no pacemaker in the body or the form may be incomplete. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the study, significant increases in Par j 2-specific IgG and IgG4 and a significant decrease in Par j 2-specific IgE have also been found. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This implies that participants recognized the potential seriousness of AFI and its responsiveness to treatment, but that barriers to care associated with poverty arise from an early stage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These recommendations are highly welcome, but several trials, each with a large number of patients, will be needed until definitive conclusions can be drawn.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the necessity of different measures from those used for human swallowing does not negate the validity of this animal model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For intermittent episodic pain, patients use as-needed or around-the-clock doses of oral immediate-release opioids or intravenous (IV) opioids, whereas for continuous pain, continuous IV infusions, PCA, or oral long-acting opioids, plus additional breakthrough doses, are recommended (citation, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Olson et al, in fact, proposed that the Oxford House model provides an excellent field-based setting for exploring transtheoretical processes for men and women in addiction recovery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The long-standing discussion regarding the oncological safety of minimally invasive access was addressed in recent meta-analyses that clearly showed that it is non-inferior to open gastrectomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, multi-component interventions have shown the most promise in reducing health disparities, (Chin, Walters, Cook, & Huang, 2007) suggesting that combining interventions may be one approach to promote smoking cessation among low-income and minority smokers. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other Latino individuals stated that \u201cThere\u2019s really no prejudice there (Oxford House). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous reports in AAV have similarly employed 4 RTX doses at 4 weekly intervals administered at 375\u200amg/m2 10\u201312. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Differently, both of rs1130214, rs3803300 polymorphisms were independent association with CHD susceptibility. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, compared to CVID and IgGSD patients, a higher proportion of IPH patients had unusual infections (i.e. warts, fungal infections), although the difference was not statistically significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first report to examine the miRNA associated DICER1 gene and dietary interaction as part of CRC etiology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sensitivity overall for detection of visual abnormalities associated with risk factors for amblyopia ranged from 72% (iScreen) to 84% (Plusoptix), and specificity ranged from 68% (SPOT) to 94% (Plusoptix) 17. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is interesting to note that similar findings with regard to SLC4A1\u039427 and \u03b1-globin deletions (located on chromosome 16 and associated with \u03b1-thalassemia) have been reported in earlier studies in Madang [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most striking finding from this study is the sharp gradient of risk of breast cancer with serum oestradiol concentrations in postmenopausal women, with the upper third of the distribution approximately five times more likely (95% confidence interval approximately 2-12 times more likely) to develop breast cancer than those with oestradiol concentrations in the lowest third. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the computational complexity of this process grows exponentially with the depth of search for optimal plans, which makes it infeasible to implement in all but the smallest environments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regarding limitations, the study was designed as a superiority trial We cannot therefore conclude that LA is not inferior to PA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Donor Registries and Transplant Centers must both commit to more intensive efforts to incorporate new factors into the search process for any meaningful advances in donor selection. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only CR1 rs6656401 was associated with a global measure of cognitive decline while genetic variants in CLU (rs11136000) and PICALM (rs7110631) were not found to predict cognitive change in these cohorts [Chibnik et al  2011]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, we observed altered seminal plasma-to-blood plasma ratios of IL-1\u03b1 and IL-10 in subjects with detectable HIV-1 RNA levels in seminal plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A number of gene polymorphisms involved in development of knee osteoarthritis have been identified, such as those localized in or adjacent to the encoding sequences for the vitamin D receptor [14,15], estrogen receptor alpha [19], calcitonin [20], interleukin-6 [21], SMAD3 [7], and matrix metalloproteinase-1 [22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Meintjes et al. [19] also observed that human embryos cultured in 5% oxygen consistently yield better clinical results in a fresh blastocyst-transfer (BT) program. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In order to manage liver AEs, after the first clinical experience with trabectedin, dexamethasone administration was routinely implemented to improve tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We investigated the associations of eating competence with reported dietary intake and physical activity, and with metabolic risk factors for type 2 diabetes, in a large group of Finnish adults screened for type 2 diabetes risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The variant allele of DICER1 rs3742330 is associated with CRC despite inconsistent patterns in recent literature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the favorable treatment outcomes, postoperative complications were relatively high (35%) with NTM lung disease in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The beneficial effect of co-trimoxazole, alone or in combination with glucocorticoids, at achieving remission in localized GPA has been reported in single centre cohort studies25\u201327. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, when a new piece of information on a leaf at depth d is achieved, its policy-improvement impact on the root-level actions is measured at the root of the tree, thus discounted by a factor \u03b3d. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When social support from close friends, relatives, and teachers were higher, adolescents reported lower symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From the original study of Bolton,27 2 standard deviations from the Bolton\u2019s ratio were considered a tooth size discrepancy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Beneficial effects of ARV treatment on QoL might be explained by decreasing intensity of clinical symptoms of the disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our model is exploratory, and did not control for multiple testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, intermittent streptomycin for the first 2 to 3 months of therapy was recommended for extensive disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general, we found that supportive environments were associated with more active commuting and public transit use. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If straw board becomes wet, these fungal spores often sprout and damage the board. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings challenge the translatability of systemic TNFR1 and TNFR2 from their strong role as biomarkers to a potential role as therapeutic targets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This pattern of feeding and swallowing behaviors is distinct from human swallowing in traditional videofluorographic studies, where the bolus is presented for a single swallow and oral residue is considered abnormal, with the exception of continuous eating. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we found that the postoperative pain was not significantly different between patients who underwent LPN and those who underwent RAPN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The unimodal approach to nociceptive pain (1981) Opioids remain the most important class of medications for relief of moderate to severe postoperative pain (citation 2007). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Category specificity of lexicosemantic deficits for natural kinds versus artefacts, frequently reported in patients with semantic dementia (Warrington and Shallice, 1984; Humphreys and Forde, 2001; Zannino et al, 2006), was not detected in the present study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been described in patients with dysfunction in Brodmann area 37, inferotemporal cortex and several other regions of the left hemisphere (Benson, 1985; Grossman et al, 2004; DeLeon et al, 2007; Antonucci et al, 2008; Rohrer et al, 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, other experiments and a higher sample size are necessary to better understand inflammatory aspects of CRS Type 5, CRRT, and the humoral signalling. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, rate of relapse remained high and additional immunosuppression was required in the majority of patients28,29. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future investigations of tubular damage markers and inflammatory cytokine levels in patients plasma are required to determine cellular and humoral factor expression that engenders immune-mediated imbalances. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It might have been possible to prevent the ventral implants from breaking away by involving a further, stable vertebral body in the ventral spondylodesis, or through additional dorsal instrumentation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we hypothesize a dual apoptotic signal activation: intrinsic and extrinsic pathway may be induced in CRS Type 5 mechanism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result of the first reported incident, in 19765, two supplementary questions were added to form B of the Cremation Act certificate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, with recent developments in measurement methods, various cytokines such as IL-1\u03b2, IL-8, TNF-\u03b1, matrix metalloproteinase-8, 9 (MMP-8, 9), and IL-1 receptor agonist are now being further measured. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(An et al, 2006; Fiore, Jaen, & Baker, May 2008; Zhu et al, 2002) Prior patient navigation studies (K. Lasser et al, 2011; Phillips et al, 2011) have demonstrated how navigators can motivate patients to engage in short-term behavior change such as undergoing a one-time procedure (e.g. colonoscopy or mammogram). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study was designed as a hospital-based case-control study and may have been affected by selection bias. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also observed ethnic differences in BMIz trajectories, with Malay children more likely than Chinese children to have rapid BMIz gain trajectories and Indian children more likely to have stable low BMIz or rapid BMIz gain trajectories. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contradiction to our results, Berrino et al (1996) found that the odds ratio for oestradiol decreased when adjusted for (free) testosterone, while adjustment for total oestradiol increased the association between breast cancer risk and levels of total testosterone. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study using contrast-enhanced whole-heart CMRA at 3.0T in 48 subjects, the CS and PIV were observed in 100% of subjects, the PVLV in 88%, the LMV in 69%, and the AIV in 79%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This proof of concept creates an avenue for further prospective investigation and refinement. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, future studies should also collect data on prior training and exposure to mindfulness activities and emotion regulation strategies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the smaller sample size resulting from missing data, the best-fit LARS regression models may have included more predictors (overfit) than may have been included in a larger sample. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast however, Bock and colleagues observed increased spine densities in layers II/III of parietal, somatosensory cortex (Bock et al, 2005), in Wistar rats, exposed to 1 hour daily separations, for periods ranging either from PND 1-3, 5-7 or 14-16. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some of these studies focused on different populations, such as participants with a late onset of the disorder, i.e., those who adapted to their biological sex during early life26, or gender dysphoric adolescents38. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, correlations between mean FA and BSID language and cognitive scores were mainly in the corpus callosum (which connects the left and right brain hemisphere and may play an important role in language lateralization [citation]), including the genu, body, and radiation; and in the projection fibers (which transmit neural signal from deep brain to cortex and may be a pathway for the functional integration of motor and cognition [citation]), including the cerebral peduncle and internal capsules. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also has some limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, 80% of all THA patients are diagnosed with primary osteoarthritis (Overgaard 2013), so the patients in this trial represent the vast majority of all THA patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addressing this risk may reduce delays due to reluctance to take on this burden, and those due to the need to gather funds. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, IBS-D patients had decreased mRNA expression of two TJ proteins, ZO-1 and occludin, consistent with prior studies (25, 28). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among them, rs9267673, rs2647073 and rs3997872 were already shown to be associated with LC in the initial GWAS study9. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, we should always consider cardiorespiratory physiology to be the principal determinant for FiO. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As one of many major laboratory tests, CRP is primarily used when an obstetrician needs to monitor various inflammatory conditions such as chorioamnionitis [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the causality of the associations cannot be determined with the cross-sectional design of our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of having a baby under the age of 30 was 82.8% in the previous study; the rate was 76% in partricipants at Arnavutk\u00f6y and 31% in participants in \u015ei\u015fli in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is recognized that screening programs for high-risk populations are urgently needed since almost half of HCV infections are undiagnosed.[Citatipon] Although the US Preventive Services Task Force does not yet recommend annual HCV screening in high-risk populations,[citation] the Veterans Affairs Medical Center (VAMC) encourages yearly screening for people with HCV risk factors.11 Given the high HCV prevalence among the SMI population[citation] adopting VAMC screening practices in public mental health clinics might be worth considering. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The inability to distinguish clusters might be due to the relatively small groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the ambulatory setting, oral anticoagulation, including treatment with direct oral anticoagulants, is feasible. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is limited by the restricted number of patients and by the in vitro experimental evaluations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Studies have shown that the risk of breast cancer can be decreased by about 30% with a young age at first pregnancy, multiple pregnancies and breastfeeding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Where pediatric standards were unavailable (to quantitatively evaluate vessel wall density and distal ICA mean flow velocity), we tested an age- and gender-matched healthy control cohort, with predictably larger BMI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future investigations would benefit from a more inclusive sample and more robust incorporation of levels influential in behavior. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, nearly all patients in this study who practised self-medication took analgesics only when necessary. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As discussed in the previous sections, temporal discounting of future rewards (and punishments) is a necessary component in the current framework. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This logic lay behind the elucidation of the impact on obesity of defects in SIM1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our opinion it is an effect of laparoscopy in combination with the ERAS protocol. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This survey showed that one in four of Xinjiang adults aged \u226518 years had hypertension. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In cases of severe inflammation with \u201cheparin resistance,\u201d additional monitoring of anti-Xa activity levels (target range: 0.3\u20130.7\u2009IU/mL) is recommended. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings from different ethnicity conducted in the United States showed that the prevalence of hypertension was 40.5% in non-Hispanic blacks, while 27.4% in non-Hispanic whites [31]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the low friction arthroplasty is often considered as the gold standard in terms of polyethylene wear, Isaac et al. demonstrated that stainless steel femoral heads became roughened in vivo, mainly by particles of radiographic contrast medium, and assumed that the harder ceramic femoral heads would give a bearing surface which would not be damaged so easily [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should include these scales to support more valid clinical implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison with Sanford and Myers [15], who reported superficial infection of the wound in 1.1% of 486 patients after fixateur interne implants, our infection rate (17%) differs significantly. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this model is not strictly applicable to our study, since our patients, who had adequate gluten exposure in their diets, were not preselected for evidence of gluten intolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cystatin C, neutrophil gelatinase-associated lipocalin, or those combined in the NephroCheck\u00ae could have been used to detect renal failure at an earlier stage and/or with a higher sensitivity 38\u201340. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Short-term benefits of such modern perioperative care were proved by numerous randomized controlled trials on patients undergoing colon or rectal resections [19,23]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Next, as in most chronic pain research, we assumed that the pain condition is a stressful situation but we did not measure this explicitly which can be seen as a drawback in the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, Romero et al. [6] reported correlations among the existence of a placental inflammatory lesion, inflammation level, and choriodecidua inflammation pattern via amniotic fluid culture results and amniotic fluid white blood cell counts, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Norwegian arthroplasty register at 4.5 years 99.1% of the Zweymu\u00c8ller Alloclassic-SL stems had not been revised [14]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two surgical departments (otorhinolaryngology and general surgery) and 11 surgeons performed thyroidectomy in the present study, and each of these clinicians used their preferred method of pain management. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over the course of the intervention, participants may have learned more standard classification of PA, so that by the final assessment, they reported their PA levels more consistently with these standards. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our discovery that mice pretreated with ANP exhibited a dramatic reduction of LPS-induced pulmonary metastasis of introduced cancer cells provides direct evidence that ANP can prevent tumor metastasis in mice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "So far, most research is focused on GDF5 (growth differentiation factor 5) [23,24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, for several reasons, follow-up information was not available in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, all of the outcome measures were assessed on the basis of self-reported responses, which could inflate associations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The follow-up period in both these studies was short, with a mean of 3.5 years reported by Berrino et al (1996) and a median of 2.9 years reported by Dorgan et al (1996). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the smaller the \u03b3 is, the less valuable a given uncertainty reduction is. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the differences in both HOOS and EQ-5D between the 2 approaches were small, and it can be questioned whether the differences are above the minimal clinically important difference (MCID) (Ehrich et al 2000, Roos and Lohmander 2003, Terwee et al 2009, Larsen et al 2010, Roos 2012, Coretti et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There have been no detailed immunophenotypic studies in cohorts of asymptomatic relatives of patients with PAD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several large prospective cohort studies have supported the lack of an association between dietary lutein/zeaxanthin intake and CRC36,37. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As detailed in Table 2 and Figure 2, this biker position was shown here to reduce myocardial attenuation and corresponding artifacts, as compared with the sitting or supine position, with this reduction mainly involving the basal portion of the inferior area, similarly to that previously reported for the prone versus the supine position. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Extending such programmes to cover high-cost care would help to mitigate the financial ruin that can stem from acute illness. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since most predictors of outcome in first-episode psychosis are not modifiable and DUP remained a significant predictor of outcome after adjusting for the effects of many other variables, DUP could prove to be a target for secondary preventive efforts in early psychosis (Harrigan et al, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both patterns of prioritization have been reported in care-seeking for acute febrile illnesses in different contexts [37, 38]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such maladaptive vascular remodeling would predict lower arterial compliance and impaired flow reserve. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In most cases, AST and ALT elevations are transient and occur within the first two cycles of treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future energy balance interventions could adopt social support strategies from peer provided mental health services\u2014to employ the shared experiences of a condition, but using the changed health behaviors of a peer to promote \u201crecovery\u201d [14]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All primary cell cultures expressed significant amounts of angiogenin. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These autopsy studies have described a diffuse arteriopathy marked by striking depletion of vascular smooth muscle cells from media, along with deposition of replacement proteoglycans and collagen in both media and adventitia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is in line with earlier research (Dezutter et al, 2010) showing that a central religious meaning system can function as a buffer for the negative impact of pain on the life satisfaction of pain patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "-, presumably because the values were above the measurement range of the CDI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The authors also suggested that the stability of the trocars used during robot-assisted hysterectomy likely reduced the degree of trauma to the abdominal wall, pain intensity, and opioid requirements. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Nepalese setting, this study is a first step towards understanding social anxiety symptoms in the adolescent population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite poor healthy eating and physical activity behaviors and high BMI, most drivers perceive their health to be good or even very good (73.4%), and most (75.6%) report contemplating, planning, or actively making changes to improve their health. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Just as the same object goes by different names in different languages, the same noun (e.g. compass) may denote two completely different species of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results showed that intrauterine inflammation may be prenatally predicted even without the use of an invasive diagnostic method such as amniocentesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the true clinical impact of this finding remains to be properly defined, it may be hypothesized to play a role additional to that of the upward LV shift, in the enhanced separation documented with the biker position between the inferior wall and subphrenic organs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, participating teachers learned to use the A2i software, assessment information, and classroom implementation well enough within 1 school year to make a meaningful difference in their students\u2019 reading achievement when they received a professional development regimen that, while intensive, could be replicated at scale. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our sample size was small due to the exclusion of 11 subjects (35% of the sample) with HIV-1- RNA levels <200 copies/ml. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In order to approach functional interpretations of our results in future, we will need to determine the cellular substrate for the rather dramatic change in cortical size we have observed in our mice; and we will need to further examine if there are correlates with specific behavioral changes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association between cognitive function and these two loci as well as PICALM was examined in 1,666 subjects enrolled in the Religious Orders Study (ROS) and in the Rush Memory and Aging Project (MAP). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A prospective longitudinal study examining both parasitemia and malaria morbidity in children would better elucidate a potential protective role of GYPC\u0394ex3 and SLC4A1\u039427 in PNG and other Melanesian populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, straw has been suggested as a possible source in several outbreaks (15,27,38,39). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the introduction of blaCTX-M-15 seems to be related to the acquisition and persistence of an IncFII plasmid harboring FIA/FIB replicons, which was also observed in ST131 (22). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We previously showed that \u223c45% of patients with symptom phenotype of IBS-D have accelerated transit (7); we did not investigate the relationship to HLA-DQ status in that study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings clearly demonstrated that high ARR levels, low PRA and serum potassium were significantly and independently associated with primary aldosteronism in most of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mismatch of oxygen demand and oxygen supply is responsible for organ failure in different pathophysiological conditions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In response to recurrent inflammation, it may therefore be advantageous for metabolism to respond flexibly within a genetically defined norm of reaction to preferentially store body fat to meet subsequent immune-related energy costs and avoid further deficits to growth. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If the feral cat had been infected with Q fever, the employee would most likely have had evidence of past exposure to C. burnetii. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In aging, increased ICA flow velocity directly correlates with degree of stenosis 32. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding is in line with recent studies suggesting the positive role of hormonal therapy in the quality of life of transsexuals51,52. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the significant interpatient variability in aminoglycoside volume of distribution and the lack of an explanatory covariate, dosing to target the area under the concentration-time curve (AUC) rather than Cmax may be preferred. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional analyses showed that this blunting of intra-category distinctions in the N400 response was selectively correlated with atrophy at the tip of the left but not right temporal lobe. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PCR test used was also experimental, although the protocol followed was similar to that used in Australia, France, and Germany. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All four of those genes have some connection to prostate cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, p38 has been described as a key mediator linking TNF to increased ABCA1 expression in macrophages (54). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although many clinical trials aimed at preventing cancer recurrence during the perioperative period have been conducted, no prophylactic treatments have been established. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanistic link which could explain the association between menarcheal age and genome-wide DNA methylation, but not in individual CpG loci is yet to be determined. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epidural analgesia is effective and safe in surgical cancer patients (citation, 1994). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The key advantage of this approach is that carriers identified from population cohorts are not biased (either qualitatively or quantitatively) by pre-existing ascertainment criteria, so that the impact of the GSV on phenotype can be directly analysed using more powerful quantitative methods. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although our analysis of tagging SNPs from genes involved in mitotic entry, the mitotic checkpoint, and cytokinesis did not identify significant associations when accounting for multiple testing, exploratory analyses revealed interesting patterns of association among the genes in this biologically relevant pathway, particularly with respect to histologic grade of breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a clinical study, Gogali et al. reported that serum levels of soluble E-selectin in lung cancer patients were significantly elevated compared with those in control subjects (32). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has not been possible to obtain the formula, which is used by the CDI to convert the values from the actual temperature to 37\u00b0C values, and therefore we cannot exclude the possibility of an error source in this context.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New infarcts with thinner, normal-looking collagen fibrils were not hyperechoic. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, inflammation and hypoxia in COVID-19 lead to a prothrombotic state, which is usually not in accordance with the ISTH definition of overt DIC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the theoretical front, our algorithm can benefit from several improvements, most notably, from relaxing the assumption that the environment has a deterministic transition structure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the only significant SOT predictor we found was visual integration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The statistical models used in this study are highly similar to those used to compute teacher value-added scores; hence, the positive treatment effect means that teachers in the ISI condition generally had higher value-added scores compared with teachers in the control condition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This abnormality may be an early indicator of an ongoing process that culminates in plaque formation, as a consequence of narrowing of the distal ICA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A large proportion of patients were excluded from this study due to lack of CT imaging, highlighting the fact that this is not necessarily a routine test in all patients treated with aminoglycosides. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such static assessments of BMI provide a snapshot of the \u201cintensity\u201d of adiposity, while ignoring the dynamics of BMI over time, such as duration, age of onset, and rate of rise of adiposity, which may have profound effects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In an in vitro study, dietary lutein inhibited colonic aberrant crypt focal development in rats, suggesting that it may help prevent colon carcinogenesis38,39. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is no consensus on common cancer screening programs worldwide because the screening programs in each country vary depending on sociocultural and ethnic structures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pain in the thigh and stem subsidence are worrying features commonly reported in series of cementless femoral prostheses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Changing diet may be especially challenging for people who are already overweight or obese. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to previously reported seminal plasma cytokine levels for healthy men,22 we noted elevated levels of the proinflammatory cytokines IL-1\u03b1, IL-6, and RANTES and decreased levels of the immunosuppressive cytokine TGF-\u03b2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Studies showed distance from home to work was a strong predictor of uptake and maintenance of active commuting, and local planners may be able to co-locate new residential developments and workplaces, thus reducing the distances required to travel to work [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our opinion, the most straightforward explanation of the positive genetic association reported in the original study may be the very small sample size of its patient group (n = 18) that may not reflect real distribution of MCP-1 \u22122518 A/G SNP in German patients [13]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This decision was based on published evidence and related RCT studies using the HOOS questionnaire as the primary outcome measure (Ehrich et al 2000, Roos and Lohmander 2003, Terwee et al 2009, Roos 2012, Skou et al 2012, Villadsen et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should investigate time of diagnosis with atopic dermatitis to clarify the causal relationship between stress and atopic dermatitis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our recommendation for the use of the CDI in emergency cases where there is no time to gas-calibrate the CDI before the start of bypass, is to not trust the values on the CDI display until after an invivo calibration has been performed against standard laboratory results.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the 109 28 mm-ceramic-PE bearing surfaces available for measurements of radiographic wear after a minimum of 5 years in vivo, only one hip has shown a cranial PE-protrusion rate of more than 0.2 mm a year. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the national Youth Risk Behavior Survey monitors in the US in 2011, the alcohol consumption rate of 9th through 12th grade students of boys was 39.5%, and girls was 37.9% [46]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Importantly, optimal opioid dosing is based on the temporal characteristics of pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of smooth acetabular threaded components is no longer recommended, and we agree with this. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also highlights the caution required when interpreting data derived from a heavily-selected cohort \u2013 carriers of a GSV drawn from such a cohort do not necessarily accurately reflect the phenotypic effect of a GSV in the general population. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite these differences, these conditions both result in high opioid demand and pain intensity8. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One other alternate hypothesis is that the source of the outbreak was outside the factory building. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The associations of eating competence with these metabolic abnormalities were at least partly mediated by adiposity because statistically significant associations were not observed after adjustment for BMI, except for the metabolic syndrome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many complications that arose after ventral spondylodesis were complications of a general surgical nature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All samples in this study were collected prior to the onset of disease, and the changes observed were present in the blood of individuals when they were still healthy, at least five years prior to their diagnosis, limiting the potential influence of the presence of cancer (reverse causality) on the methylome of blood DNA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the same way, hormonal therapy, by inducing external physical modifications, can reduce the feelings of foreignness or strangeness that individuals sometimes report, thus explaining the scores found on the Schizophrenia scale which decrease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here, ventral spondylodesis showed significantly better results than ventro-dorsal spondylodesis 2 years and 5.4 years postoperatively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, studies investigating the importance of SHBG in the aetiology of breast cancer have reported inconsistent findings (Key and Pike, 1988). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study found that most cannabis users make multiple attempts to stop or reduce and such attempts continue over time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, they had a similar though less pronounced decrease in BAFF-R and increase in HLA-DR and CD40 expression on B cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The loss-of-function defect in this case of congenital myasthenic syndrome is attributable to the left shift in the voltage dependence of fast inactivation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the factory strongly emphasizes controlling vermin as some of their cardboard packaging is used as secondary packaging in the food industry. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the prevalence of refractive amblyopia correlates well with the severity of the vision abnormality,6 the risk for bilateral ametropic amblyopia in these eight children could be considered low. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The theoretical framework we presented here is readily compatible with either case. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, this study is the first to examine QoL among HIV-infected individuals in Georgia, making this a new direction in HIV research in Georgia as well as in the Caucasus region. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, FA and BSID cognitive correlation was observed in the fornix. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pattern of relative risk for infection in groups of participants at different machines on the factory floor is consistent with this hypothesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mean number of harvested lymph nodes was 34.7\u00b117.2; there was only one patient (T2N0) who had fewer than 15 lymph nodes retrieved. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As expected for a loss-of-function, action potentials in affected muscle have smaller overshoots and slower rates of rise. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, treatment includes anticonvulsants (Bone, Critchley, & Buggy, 2002) and TCAs (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002; Rogers, 1989), which are known to have clinical efficacy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That study showed a statistically signifi - cant difference of 4.0 points on the HOOS-ADL subscale in favor of the PA group (Amlie et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other Hypotheses We considered a range of alternative hypotheses but did not find any evidence to support them. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If the clinically relevant difference was less than 10 points on the HOOS subscales, the study may have been underpowered to show this with a statistically signifi - cant value. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subsequently, RTCs were incubated in vitro with plasma of CRS Type 5 patients and showed higher apoptosis and necrosis and lower viability when compared to cells incubated with control plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, analyzing serum creatinine is cheap and readily available even in smaller hospitals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cytokine-like hormone leptin, produced by adipocytes in association with total fat mass (45) and demonstrating positive direct and indirect effects on bone growth (46), represents a promising endocrine target for this research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The number needed to treat (NNT) was 14 in favor of PA, but the result was not statistically signifi cant based on the present sample size (Appendix C, see Supplementary data). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Access to health insurance will encourage early medical consultation with qualified practitioners\u2014without the need to gather funds and take on debts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, 37% of participants were classified as eating competent among individuals at risk for type 2 diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is less likely that this variable could considerably affect the study results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, we performed formal interaction testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cavanagh et al (2002) found 1 field vole with advanced TB to have had all of its lung lobes containing tuberculous nodules of up to 10 mm in diameter. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is also interesting to note that men with atypically high seminal plasma HIV-1 RNA levels relative to blood had increased Th1 cytokines IFN-\u03b3 and IL-12 in the blood plasma and decreased levels of Th2 cytokines IL-5, IL-8, and IL-10 in the seminal plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The magnitude of the differential N400 elicited by the matching versus mismatching probes can be used to measure the acuity with which taxonomic distances are resolved. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In still others, the atrophy is mostly in the right hemisphere or in inferior temporal cortex, giving rise to progressive associative prosopagnosia and object agnosias (Tyrrell et al, 1990; Snowden et al, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physiologically, patient-specific measures of skeletal muscle may more accurately reflect total muscle mass than coarse measures like height, weight, and sex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, some studies have reported that hysterectomy could be conducted at any time after cervical conization as long as patients were in the appropriate condition, rather than precisely within a period of 48 hours or >6 weeks [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed few consultations with non-allopathic traditional healers, either by MPI poor or non-poor households. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, discount factor has a non-monotonic effect on vur and thus, on the depth of planning. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Researchers have established the physiologic mechanism linking stress and uncontrolled eating and reduced cognitive resources to choose healthy foods [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The house became my house.\u201d ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, renal function estimated via the Cockcroft-Gault equation, irrespective of body weight used, as well as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, accounted for only around 22 to 23% of the variability in aminoglycoside CL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Research has demonstrated that enhancing the dose of the intervention may produce better outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding is consistent with the elevated augmentation index previously detected in HGPS 5. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This observation was also confirmed in the two sub-analyses that evaluated the same outcomes in patients reporting ALT/AST increases versus those with no increase, and in patients with ALT/AST elevations \u226515\u2009\u00d7\u2009ULN versus those with ALT/AST elevation <15\u2009\u00d7\u2009ULN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, B. anthracis spores have been recorded as surviving for 71 years on dried silk threads (19). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous study results on age at menarche and methylation were conflicting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we know of no test of the efficacy of pre- vs. post-quit attempt activities in cannabis cessation, several studies on tobacco self-quitters have found that preparatory actions such as telling someone that one is trying to change (Cobb, Niaura, Donaldson, & Graham, 2014) (Hughes JR et al, 2014c), and post-cessation actions such as coping behaviors (Fiore et al, 2008) predict abstinence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This hypothesis is further supported by the absence of MBD3, which is part of the core NuRD complex, even if its constitutive presence in NuRD corepressor complex has been questioned [51]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In vitro and in vivo studies analyzed the prebiotic effect and fermentation properties of raw and roasted almonds, as well as almond seed and almond skin [40,44,45,46,47]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sensitivity and specificity data could not be obtained due to the lack of follow-up with formal vision examination in the at-risk children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No significant improvements in C-statistics for all fractures or hip fractures were seen when GRS63 was added to a base model already including BMD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study adds to the several studies that have validated symptoms of cannabis withdrawal (Del Boca & Darkes, 2003), by adding an externally valid test of these symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, the number of subjects in some of our subgroups (non-white race, had CVD event, smokers) was limited, raising the possibly that we may not have identified some clinically meaningful subgroup differences as statistically significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is as if the acuity of word\u2013object associations has been diminished (or as if the grain of representation has become coarser) so that words are easier to understand and link to objects at the generic than at the specific levels of representation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inflammation-Related Tradeoffs with Childhood Growth Are Buffered by Body Fat and May Have Lifetime Metabolic Effects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among opioids, morphine has been the gold standard for control of postoperative and chronic pain (Anghelescu, Oakes, & Popenhagen, 2006; Chou, Clark, & Helfand, 2003; Collins & Weisman, 2003; Quigley, 2005; Vascello & McQuillan, 2006; Zernikow et al., 2006). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The biomarkers investigated in this study reflect the immunological diversity that spans these patterns. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, increasing tubular pH decreases the generation of free radicals that are responsible for CIN 30,31. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general, amniotic fluid analysis and histologic examination of the placenta are important methods of diagnosing intrauterine inflammation. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There have been several more recent reports in which the AD GWAS loci have been evaluated more comprehensively and either eight [Vivot et al  2015] or nine [Carrasquillo et al  2015] AD-associated loci were tested for association with cognitive decline, including ABCA7, CD33, CLU, CR1, and MS4A4E that were nominally associated with cognitive phenotypes in the ARIC study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The large effect of elevated CRP on child short-term growth is consistent with research involving in vitro models and chronic inflammatory diseases indicating that CRP and upstream proinflammatory cytokines inhibit bone growth via multiple direct and indirect pathways (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While patient navigation may be sufficient to change short-term behaviors such as participation in screening, it may not be sufficiently intensive to promote longer-term behavior change as is necessary with smoking cessation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One limitation of this study was missing data on some of the demographic information and some of the assessments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The strict exclusion criteria may have limited any generalizability of the results to other patient groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accessing the national collection of E. coli ST410 from Denmark, a cutoff value of no more than 40 SNP differences to the nearest neighbor seemed to define clones within this collection, as the closest genome differed by 159 to 185 SNPs to PC40-1 to -4 (see Fig. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that the finding of limited documentation of pain intensity is a reflection of both the historical under-appreciation of pain in children in the 1980\u2019s and 1990\u2019s, and the lack of a structured institutional pain service until 2000 to lead the implementation of cultural changes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Grade 3/4 increases of ALT were reported in about 40% of patients after the first two cycles of chemotherapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, there are a large number of patients (14/56) with chronic kidney disease presented abnormal shaped in adrenal gland, which was defined as full shape not hyperplasia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, the present study demonstrate the good persistence of protection against HBV in a large sample of HCSs exposed to occupational health risk during the training programs, more than 20 y following the primary immunization courses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, we expected cognitive re-appraisal to be a mediating factor in the relation between prayer and pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower commuting distances and the availability of walking and cycling infrastructure were also associated with active commuting, which aligns with previous research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This in turn may lead to a more accurate assessment of creatinine production, which is determined by the rate of muscle catabolism, thereby improving estimation of creatinine clearance and aminoglycoside CL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, our study did not measure other cardio-metabolic biomarkers such as blood glucose, insulin, lipids, triglycerides and C-peptide, and thus lacking outcomes such as dysglycemia or dyslipidemia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the performance characteristics of the microscopic detection method are very poor and cannot help in the diagnosis of MFI. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The age-profile of EV-D68 hospitalised cases is potentially due to young children and older adults being most at risk of severe acute respiratory infections. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "N-acetylcysteine has been evaluated in different meta-analyses that lead to incongruent results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results raise the possibility that built environment attributes found to facilitate active commuting in higher-income countries do not fully generalize to LMICs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the most rooted dogmas in gastrointestinal surgery is the idea that an oral diet after resection should be introduced gradually, meaning nothing by mouth during the first few days after surgery, liquid meals in subsequent days, and full hospital diet within 4\u20135 postoperative days. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Approximately 20% of our group R patients received propofol for maintenance of anesthesia, which might explain the lower incidence of PONV in this group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may not altogether have eliminated the risk of measurement/registration errors, but has reduced the error size considerably. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both the GRS63 and the GRS16 predict fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lean or adjusted body weights have been demonstrated to best predict the volume of aminoglycosides in obese patients, yet they explained only around 1 to 4% of the observed variability in any measure of volume in this study (4, 5, 9). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Is intensified anticoagulation with intermediate or full therapeutic dosages required to protect hospitalized patients from VTE? ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, a careful separation of the bladder and ureter from the cervix was recommended to minimize morbidity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, we found that in our setting an intervention with home BP telemonitoring and pharmacist management improved BP control and lowered BP overall, but was particularly effective in younger patients, those without diabetes, those with elevated diastolic BP, and patients treated with fewer than three medication classes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in cases of minor surgery such as thyroidectomy, continuous infusion of remifentanil can be inconvenient and expensive. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, correlational analyses showed that prayer is indeed positively related to pain but only to pain tolerance, and not to pain severity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A higher PaO2/FiO2 ratio could be observed at the PEEP level of 8\u200acm H2O, which should be associated with more well-distributed ventilation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, even with the total of 28 biopsies (13 from HLA-DQ2/8-positive and 15 from HLA-DQ2/8-negative patients), the effect sizes in SB inflammatory cells that could be detected between the two groups with 80% power (at \u03b1 = 0.05) were 48% for CD3 lymphocytes, 50% for CD8 lymphocytes, and 31% for mast cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, all BMIz trajectories in the first 2 years were significantly associated with obesity at 5 years (a negative association for stable low BMIz trajectory and positive associations for stable high BMIz and rapid BMIz gain trajectories), while BMIz \u226595th percentile at 2 years was the only static measure with a significant association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings show that Turkey has not reached the targeted aims of the breast cancer screening programs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They found tidal impedance increased only in the nondependent parts in the patients without lung disorders after decreasing the PEEP from 15 to 10\u200acm H2O. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, this study has shown that the GRS63 predicts BMD, but not BMD change, in older Caucasian participants, suggesting that the genetic determinants of the acquisition of BMD differ from those of BMD change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LC is an increasing cause of morbidity and mortality, responsible for more than one million deaths every year4,19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, experimental studies of the survival of C. burnetii spore-like forms have not demonstrated survival beyond 8 years (Table 6) (5,6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early-life energetic experiences have lasting impacts on phenotype (47\u201349). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result is also consistent with the JACC study25, where long duration of sleep was associated with total stroke and ischemic stroke in a large cohort of Japanese men and women, our study extended the association to hemorrhagic stroke also. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In some patients with COVID-19, a prolonged APTT, which is frequently considered indicative of a systemic \u201ccoagulopathy,\u201d may actually be caused by a lupus anticoagulant, 33 thus conferring an increased thrombotic rather than an increased hemorrhagic risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The above conclusion is consistent with the ProTECT III Trial's conclusion regarding its primary outcome measure, the GOSE, in demonstrating no compelling evidence for a neuroprotective effect of progesterone at 6 months after injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The surveillance data here provide evidence of current EV-D68 circulation in Wales. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, patients operated using the PA had less self-reported limping at 12 months. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the exact mechanism by which they shift the relative abundance of microbial communities and modulate fluctuations in the microflora composition in the gut in favor of butyrate-producing microbes is unknown. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Mayo Clinic experience with contemporary cementing techniques using the Harris Design II component (HD-II, Howmedica, Rutherford, New Jersey) showed a rate of 1.6% of definite or probably loose stems at 5 to 7 years [25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is comparable to the rates in other reports; however, the leakage rate was relatively high and may be the result of the small number of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The notable finding of the current study was a considerable decrease in the development of PPCs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We framed our study in the transactional theory of stress and coping (Lazarus & Folkman, 1984) and we tested the mediational role of re-appraisal in the association between prayer and pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the original GEFOS GWAS meta-analysis on BMD, the predictive value of the GRS16, but not the GRS63 was evaluated for fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the complexity of care-seeking behaviour, we hope to gain a clearer understanding of the decision-making process, and the differential effects of poverty at different ages, through an ongoing qualitative study of this population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taking this into account, we can speculate that MCP-1 \u22122518 A/G SNP may be related to a particular phenotype of SSc. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the relationship between education and general QoL was not documented in previous studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, we identified five OTUs that were significantly associated with walnut consumption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuous administration of remifentanil during major operations has distinct advantages, such as maintenance of stable vital signs, applicability to patients with kidney and liver conditions, and reduced respiratory depression30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While speculative, immune-related energy constraint may have played a similar role in the evolution of extended subadulthood and a unique childhood life stage in the genus Homo (11), particularly given lifestyle changes (e.g., home-base foraging, enhanced sociality, increased physical activity) expected to elevate pathogen exposure in parallel with the evolution of increased brain size, body fat, and metabolic rate (17, 73\u201375). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show that the allele frequencies for both SLC4A1\u039427 and GYPC\u0394ex3 polymorphisms differed in two ethnically and geographically distinct populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hemostatic parameters should be monitored in all hospitalized patients with SARS-CoV-2 infection. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are supported by the findings of an exploratory analysis of the safety and efficacy outcomes in pooled data from phase II trials of single-agent trabectedin in heavily and non-heavily pretreated patients with recurrent ovarian cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such a response would be adaptive during childhood but could lead to obesity and poor metabolic health later in life should energetic conditions change (e.g., in association with economic development). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rest of four HBV-related LC risk-related SNPs (rs9267673, rs264707, rs3997872 and rs9275319) were all located in molecules that belong to the HLA class II, which has been considered to be the most important host factors with respect to outcomes of HBV and HCV infections. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recently, one prospective, randomized trial revealed that a better microbiological response was observed in patients treated with the regimen including streptomycin (20). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lack of a relationship between cell-mediated immune function (i.e., EBV-Ab levels) and growth in the present study may similarly reflect poor correspondence of time courses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although Georgia has achieved considerable success in controlling HIV/AIDS through prevention and treatment programs, social problems related to QoL, including stigma and discrimination, still remain challenges in PLWHIV. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is crucial to confirm whether beliefs about medicines are associated with self-medication as these findings can provide guidelines in public education to improve the safety aspects of self-medication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ECPs had healthier dietary patterns and ate main meals more regularly than NECPs in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Kolb and Cioe subsequently confirmed these observations in Long Evans rat for parietal cortical areas closely corresponding to our sample area (Kolb & Cioe, 2001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this way we reproduced in small scale what happened in renal tubules of CRS Type 5 patients when systemic disorders induced cardiac and renal dysfunctions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has several limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, this finding may result from the observation that EBV-Ab levels, similar to those of CRP (37), can be impacted by stimuli other than antigen exposure (38). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A study conducted in Turkey showed that patient gained most of their information from health care professionals (Y\u0131lmaz et al, 2013). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Kutschera et al. [19] and Huo et al. [16] have reported no loosening at 5 years and at 3 to 6 years respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite increased government investment in public-sector healthcare, serial community surveys have shown falling perception of quality and satisfaction, with highest dissatisfaction among the poorest households [28]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Truck drivers are a highly-mobile, pressured and hard-to-reach group, and traditional health promotion strategies may be limited in their effectiveness 3. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings reinforce the idea that BIM plays a major role in the surveillance against tumorigenesis in NPM/ALK-positive lymphomas and possibly in several lymphoid malignancies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The extrapolation of the results should consider these particularities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Third, in agreement with our previous study 5, we found that a significant fraction of patients had systolic and diastolic BP above the 95th percentile. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If straw board had been contaminated at some time in the past with a concentrated source of C. burnetii, drilling into this could have produced a cloud of dust containing large numbers of C. burnetii sporelike forms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sensory integration deficits included abnormal use of vestibular and somatosensory information for postural control as well as inadequate visual preference (Table 2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "71) by fostering extended periods of development and delayed maturation under energetically challenging conditions (27, 72). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observation that the prevention of relapse or recurrence is often neglected may be attributable to the fact that many patients are reluctant to take (or physicians are reluctant to prescribe) long-term prophylactic treatment with antidepressant drugs with sometimes burdensome side effects after the acute symptoms of depression have disappeared (Keller and Boland, 1998; Montgomery and Kasper, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, like previous 1.5T MR cardiac vein imaging studies [6\u201310], we did not compare our 3.0T whole-heart CMRA technique with the current invasive gold standard, retrograde cardiac venography. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the 1980s, other screw rings have been available with creation of the same gritblasted surface like that on the Alloclassic-CSF cup. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since anecdotally NP is often persistent and is reported by our patients to interfere with sleep and rehabilitation after LSS, the pain management service evaluated the prevention and treatment of NP. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In unadjusted models with NEWS-India aggregate scores, the active commuting model was significant, while the public transit model was not. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "synthesis pathways as a key signaling protein. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the beginning of menstruation, hormonal changes may play a significant role in increasing atopic dermatitis' severity during puberty and adolescence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Different forms of immune function entail different physiological profiles, each implying unique temporal and absolute patterns of energy use (5, 39). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the study was conducted in three different regions in Finland, which reduces selection bias at the population level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a series reporting on pain assessment and documentation at our institution, we found the rate of documentation of pain intensity scores had increased between 2000 and 2006 from 77% to over 95%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Once mass was accounted for there was no significant difference in prevalence between males or females. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide further evidence that over-nutrition in utero may lead to high-risk BMI trajectories during early childhood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During routine CPB cases, it is, in most centers, possible to have laboratory blood gas analyses performed whenever necessary, but in emergency surgery, often performed off normal working hours with little or no extra personnel available for errand running, reliable in-line monitoring is a valuable tool for the perfusionist in the acid-base management of the perfusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pulsatile cortisol infusion was more inhibitory of pulsatile ACTH secretion than continuous cortisol infusion, specifically as a function of E2 concentrations in postmenopausal women. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the latter case, it represents interaction between instrumental model-based and instrumental model-free processes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "External lesions were only found on adult voles of mass >17 g, with prevalence generally increasing with the age of individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After adjustment for FN-BMD, the effect sizes for the associations between the GRS63 and hip fractures (\u221264%) and all fractures (\u221250%) were substantially reduced and for hip fracture no longer significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The top significant genes identified included DEF8, DBNDD1, SPATA33 and MC1R. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The limitation of this study, however, is its retrospective design and the results here should, ideally, be confirmed by subsequent larger prospective studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Commonly, methylation of the promoter or the 5\u2032UTR of a gene is just the first step of a long series of events leading to gene silencing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A second statistical issue, common to all scans for variant associations, is that each of the many GSVs detected in even a small cohort is the subject of a separate independent hypothesis, so that substantial multiple testing correction of the significance threshold or rigorous control of the false discovery rate (FDR) is required if a large type I error rate is to be avoided. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In these trials, patients showed systemic reactions rates ranging from of 0\u00b728\u201346\u00b76% and local adverse reactions rates ranging from 0\u00b766 to 66\u00b76%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When acute pain is not well managed, the patient is at greater risk of chronic persistent pain (Joshi & Ogunnaike, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have found that the overweight and obesity are the risk of hypertension [17,18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both of them could be considered to be of the cluster type, as they involved two separate injections at the first visit. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, a novel results of this study was the robust association between snorting/gasping and stroke risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the mechanism is still not well-understood, it is believed that this may occur through increased transfer of maternal energy substrates, such as glucose, lipids and amino acids to the fetus28, 42, with the combined increase in all fuels likely contributing to the development of high-risk trajectories during early childhood28. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Liksul, the SLC4A1\u039427 and GYPC\u0394ex3 allele frequencies were high, thus allowing us to examine the interactions of both band 3 and glycophorin C genotypes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interactions among HLA-restricted T lymphocytes, B lymphocytes, natural killer cells, and cytokines influence immune response to viral infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, Krause (2004) showed that attitudes towards prayer may be important variables relating to psychological outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Katherine et al reported no association between walking distance to fruit and vegetable retailers with the risk of prediabetes/diabetes in Australia (Baldock et al, 2018). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the pneumoperitoneum period, the PaO2/FiO2 ratio in the E group was better than that in the C group, although no significant difference was ascertained in both groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study assessed the immunological performance of HBV vaccination after 2 decades since the beginning of the national immunization program, updating the state of the art on this relevant issue in Italy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pure retrieval anomia occurred in the presence of a putative object\u2013word interface that appeared functional enough to support the accurate matching of the unnamed object to its name during the pointing tasks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survey was large in scale and relied on a complex design including multistage sampling, stratification, and clustering. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Understanding the molecular genetic basis of a common disease casts light on the biological factors involved in disease initiation and progression, and may suggest new treatment strategies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This exploratory study provides new evidence on neighborhood environment attributes associated with active commuting in India, a rapidly urbanizing LMIC context. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional long-term longitudinal studies are needed to establish causality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A higher density of highly processed and take-away food vendors was associated with an increase in BMI/waist circumference and blood pressure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Investigations on semantic dementia have tended to attribute the naming failures in patients with anterior temporal lobe atrophy to impaired general knowledge of the object rather than a specific impairment of verbal retrieval (Snowden et al, 1989; Lambon Ralph et al, 2001; Adlam et al, 2006). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Greater ACTH suppression by cortisol in women given E2 differs diametrically from most data obtained in animal studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The aminoglycoside use patterns at our institution suggest that a significant proportion of these patients are likely critically ill, as aminoglycoside prescribing outside the intensive care unit is uncommon. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this kind of model, network hubs have a \u2018transmodal\u2019 architecture where multi-modal (though not pan-modal) convergence does take place but in the presence of domain-specificity, and where inter-network integration is more distributed than confluent (Mesulam, 1990, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A psychological profile assessment can help a multidisciplinary gender dysphoria team to detect potential psychopathological factors of vulnerability, changes and stabilization over time of the abilities of adaptability of the individual. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accelerated CVD leads to debilitating morbidity in HGPS, and culminates in mortality from myocardial infarction or stroke at an average at of 13 years 6. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These include localization of the site of attachment of the mass as well as the extent of involvement, reliable estimation of tumor size, and identification of adherent or coincident thrombus. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As we did not see any side effects, the administration of theophylline is safe even in critical ill patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, our data showed a strong correlation between self-reported pre-pregnancy weight and measured booking weight (\u03c1\u2009=\u20090.96), and sensitivity analyses using booking BMI as a predictor showed similar observations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other successful navigation interventions have taken place over six months and have included full-time navigators.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, E-selectin is considered to play a central role in hematogenous metastasis (16\u201318). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The support for a first-grade inoculation effect was inconsistent and inconclusive. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the mean concentration of SHBG is lower in the cases, one might expect higher percentages of non protein-bound oestradiol in the cases than in the controls, as previously reported in the Guernsey cohort (Moore et al, 1986). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most common arch forms were narrow tapered followed by narrow ovoid in both males and females and in all the 3 Classes of malocclusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the contrary, Nfatc1nuc mice (DT) fed doxycycline chow for 4 months developed podocyte loss, glomerulosclerosis, elevated serum creatinine, and increased collagen staining. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our inconclusive rate was high overall at 13.1% but differed by screening location from as low as 3.6% to as high as 25%, possibly reflecting both a technical learning curve as well as site specific difficulties in creating an acceptable screening environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fact, in cases where BMD is not known, a BMD measurement is more informative than an analysis of the SNPs included in the GRSs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In their multicenter clinical evaluation study they found that the CDI overestimated the pO2 values when compared to their standard, and the authors speculated that the discrepancy could be caused by the methodology of the analyzers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to our current analysis, trabectedin-related liver enzymes elevations do not affect the progression-free or overall survival of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 3.0T imaging and contrast-enhancement combined with inversion-recovery preparation allow high contrast between blood and background tissue. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the vibrating sandals were a simple prototype, a different design may elicit greater reductions in gait variability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, over the last two decades we have gained enough experience to provide versatile and high-quality oncological surgery using the minimally invasive approach. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our review of 300 consecutive primary acetabular replacements mixing Zweymu\u00c8ller grit-blasted screw rings of first and second generation showed, with loosening as the endpoint, a 99.1% survival rate at the 7 to 8 year follow-up [4]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the vascular adhesion molecules, E-selectin is essential for recruitment of inflammatory cells to damaged tissues (31), and it enables circulating tumor cells to roll and tether on the endothelium. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A hand-held metal detector (such as those used at airports) might help detect pacemakers in the mortuary. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are several possible reasons for the apparent difference between children and adults: it may reflect population differences (the child carriers of the GSV were from France and the UK, the adults primarily from Nordic countries); it may reflect cohort ascertainment, for instance that the child cohorts did not include overweight or mildly obese subjects \u2013 it is notable, however, that the deletion was not reported at a comparable frequency in cohorts of children with common obesity [16]; it may reflect a genuine attenuation of the effect of the deletion in adults, so that impact of the GSV on obesity becomes less pronounced with increasing age; or the severe obesity observed in children may have been triggered by an aspect of the modern obesogenic environment that was experienced to a lesser degree by older subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, buffering with bicarbonate helps maintain a neutral pH and therefore reduces oxygen consumption of the kidneys 30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This can be achieved by explicitly expanding a model that represents the underlying structure of the environment, followed by calculating the expected value of each plan. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mortara et al. reported the relationship between the level of NGAL at admission and the kidney function, defined as baseline creatinine and eGFR [15]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The costs to the wider Indian economy from a heavy reliance on the private car as a mode of transportation run into tens of billions of dollars every year [23,83]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Travel history for all patients in these two PO10s was unavailable, and comparison with the genomes collected from EnteroBase did not reveal any links to other countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed a lower likelihood of having new type 2 diabetes and a lower 2 h glucose concentration in ECPs than in NECPs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, there is a rationale to prevent adenosine-induced vasoconstriction in patients at risk for developing CIN. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clearly, more empirical research on reduction as a goal of treatment is warranted. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hypothesis that hay lorries passing through the docks could have caused the outbreak was known to a number of employees before they completed the questionnaire, and this finding may therefore be a result of diagnostic suspicion bias (41). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduction attempts were more common than abstinence attempts in our self-changers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This also poses a problem for replication \u2013 the failure to detect some GSVs in our cohorts may reflect low frequencies in the populations from which they were drawn. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While our predominantly white sample was appropriate for studying Appalachians, we are unable generalize results to other groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Within India, this study complements the objectives of on-going national government schemes in India, such as the Smart Cities Mission (http://smartcities.gov.in/content/), the Swachh Bharat Mission (http://www.swachhbharaturban.in/sbm/home/), and the Atal Mission for Rejuvenation and Urban Transformation (AMRUT, https://amrut.gov.in/), in aspects of urban land use and health promotion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We lacked detailed information on occupation and socioeconomic status, but exploratory analyses did not reveal any differences in intervention effect by educational attainment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Object knowledge impairments therefore appear to play a distinctly less causative role than word comprehension impairments in the associative naming failures that follow left anterior temporal lobe atrophy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "in 5 %O2 vs. 44.7% in 20% O2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This affirms the need to distinguish between the two forms of pain outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to the Alloclassic-SL stem implantation, insertion of the Zweymu\u00c8ller Alloclassic-CSF screw ring is technically easy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe these advantages outweigh its relative complexity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with stronger beliefs in Specific-Necessity may recognise the potential benefits and role of analgesics in protecting their present and future oral health against deterioration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We obviously cannot rule out the possibility that the surviving anterotemporal neurons in Patients S1\u2013S11 might contain an amodal hub though it is unlikely that the neurodegenerative process in these patients would have selectively destroyed the neurons that lack such amodal properties. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, due to low numbers, and hence broad confidence intervals, for individuals of mass >30 g in weight, it is not possible to confirm whether risk of TB increases in the heaviest age classes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dosage and time of administration vary, but especially in older studies, the statin was administered between 6 and 12\u200ah before CM. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Being overweight itself may constitute a barrier to PA [19]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Parkinsonian rats showed impairment in the oral processing stage of deglutition, evident by the increase in aberrant tongue movement without successful bolus transit to the pharynx. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result supports the findings of several previous studies, Bishara et al,7 Al-Khateeb and Abu Alhaija,10 and Uysal et al17 Even longitudinal studies found that the arch width in males was greater than in females 18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar genetic profiles have previously been reported for NDM-producing E. coli ST410 isolates obtained from patients in Denmark and the United Kingdom (21), indicating either similar travel patterns by inhabitants of the two countries or direct transmission between the countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However this practice is no longer in place due to funding issues. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, hypertensive patients who normalized their body mass index can largely improve BP level and a number of metabolic and hormonal parameters [19,20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, PWVcf was dramatically elevated overall. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current study showed that hysterectomy was safe and feasible 4 weeks after conization, with both decreased postoperative infection and lower use of antibiotics, which may be because the tissues damaged by cervical conization had already been repaired by this period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Optimal postoperative pain relief both at rest and with movement have recently been emphasized to facilitate rehabilitation and timely discharge from the hospital (Joshi & Ogunnaike, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Plasma NGAL of CRS Type 5 patients was higher when compared to controls but there was not a statistic relationship between this parameter and outcome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CLU rs1113600 T allele is associated with reduced risk of AD [Harold et al  2009; Lambert et al  2009], and was associated with a higher composite cognitive score for both men and women 92-93 years of age at enrollment in a Danish birth cohort study, while the effect of variation in PICALM (rs3851179) [Harold et al  2009] was restricted to males [Mengel-From et al  2011]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However the GRS63 cannot replace the BMD measurements as FN-BMD was superior to the GRS63 in the discrimination and reclassification of fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transmodal areas receive input from the highest synaptic levels of sensory-fugal processing hierarchies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While significantly increased colonic permeability was not observed, the cumulative urine excretion of lactulose at 8\u201324 h was increased (P = 0.10). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is a retrospective review and patients with prostate cancer are not included, although it is well documented that prostate cancer is among the gamut of tumours carrying the highest risk of developing bone metastases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This indicates that, under walnut consumption, the gut microbiota showed a slightly lower diversity than under the control diet; however, this difference was not significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its use seemed not sensible in our patients as we intended to cover emergency procedures as well as critically ill patients on the ICU. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are some limitations to the present study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Appropriate dosing of this novel compound is necessary to optimize efficacy, slow the development of resistance, and prevent toxicity in patients with the full range of body size and composition; however, the therapeutic drug assays will likely not be widely available until years after its approval (14, 15). ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EAST inhibition experiments showed that P. judaica modified extract had a 99\u00b788% less allergenicity than the native counterpart, which is in accordance with the reduction of allergenicity observed by skin prick test (99\u00b782% reduction). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The sensivity perception and awareness were higher in participants who were of a lower socioeconomic status; however, those participants were less likely to believe in the benefit of BSE, had higher perceptions of barriers and had less perception of trust for BSE and health motivation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ROC curve analysis was clearly the best performing test, and ARR showed the middling sensitivity and specificity in detecting primary aldosteronism due to the kind of hypertension with CKD involved, as well as PRA showed a little better. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This would suggest a stimulatory effect of T or its metabolites especially during pulsatile cortisol feedback, distinct from the inhibitory effect of E2 under both pulsatile and continuous feedback. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Monitoring of serum immunoglobulin levels during prolonged treatment is therefore important. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Invasive procedures are often required to investigate mechanism (for example changes in neurochemistry or muscle proteins) and cannot be performed with humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reminders from physicians have a big impact on women going for mammography. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although two Q fever cases were identified in the neighboring factory, no evidence existed of a wider outbreak involving other premises in the docks or nearby residential areas. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, these abnormalities promote dynamic increases in ventricular afterload, impaired vascular autoregulation, and cardiac and cerebrovascular decompensation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PWV, elevated BP, and insulin resistance paint a picture similar to that of the usual aging process. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study also found a significant positive correlation between beliefs in Specific-Necessity and total QAQ point. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a recent study in IBS-D patients who had previously responded to gluten withdrawal, there was no difference in symptom generation after gluten exposure on the basis of HLA-DQ2/8 status (4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Coagulation test abnormalities in the early phase of SARS-CoV-2 infection do not result in clinical bleeding and thus do not fulfill the more stringent definition of \u201ccoagulopathy.\u201d ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NTM lung disease has become a significant health problem. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The strong left hemisphere concentration of tissue loss and the paucity of peak atrophy sites in the fusiform gyrus could therefore account for the selectivity of the verbal impairments in our patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In cases of suspected VTE (e.g., acute deterioration of dyspnea, unexplained decrease in oxygen saturation, progressive peripheral edema, rapid increase of plasma D-dimers), appropriate imaging studies (CTPA, ultrasonography) should be ordered permissively. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have previously shown that the ethnic background of those recruited and not recruited differed between these two groups, reflecting our a priori plans to recruit disproportionately from the minority ethnic groups23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Piche et al. (citation) also demonstrated that, overall, IBS patients had decreased ZO-1 and occludin mRNA expression in colonic biopsies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study reviews the observation of intracardiac masses using TEE at our institution. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Georgian public health specialists working in the HIV field should prioritize implementation of such interventions among HIV patients. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since sufficient and conclusive data from human feeding trials are missing, it is difficult to determine the mechanisms by which walnuts, as part of a Western-type diet, may confer their modulating effects on microbial distribution and changes in the ratio of the major bacterial phyla. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The only subgroups of patients having a directionally negative effect of the intervention are those with diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical experience in the use of multimodal therapy may allow the development of protocols for pain management through an interdisciplinary approach that incorporates input from diverse members of the clinical care team (nursing, surgery, anesthesia, psychology, physical therapy, pharmacy).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential for misclassification bias is also acknowledged, with regard to ascertainment of MPI status in the context of acute illness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed to fully investigate straw board in various venues as a potential vehicle in Q fever outbreaks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, Hansen et al showed that a high dose of remifentanil (0.4\u200a\u03bcg/kg/min) added to combined general and epidural anaesthesia could induce OIH and/or acute opioid tolerance after major abdominal surgery at the immediate postoperative period (0\u20132\u200ah)19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Zechmeister et al[16] also reported that they observed no differences in pain intensity and postoperative analgesic use between robot-assisted and laparoscopic gynecologic surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the strong associations of the stable high BMIz and rapid BMIz gain trajectories with increased adiposity and obesity risk observed in our study were in line with recent findings17, 18, also suggesting the robustness of our study findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was a retrospective study analyzing medical records from a single center, which might result in some bias in case selection as well as incomplete clinical and biochemical patient information in some key areas. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EIT was also used to assess the modifying effects of a recruitment maneuver and PEEP on lung ventilation in patients undergoing general anesthesia for laparoscopy[Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The role of modest levels of body fat in buffering the effect of inflammation on growth underscores the close relationship between malnutrition and infection in childhood stunting (64). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relative to developed countries or even urban centres of developing countries, the commuting distances within the study villages were small, which may account for greater influence of the density of food vendors within smaller buffer zones on cardiovascular risk factors in the present study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the ARIC study, addition of the minor rs9331896 C allele associated with reduced risk of AD was associated with higher scores at baseline on the DWRT, a test of word list delayed recall in which a list of 10 unrelated words are presented visually to the participant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings indicate that pre- and perinatal brain development is pivotal for optimized cognition and neurodevelopment in healthy infants.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Between the two, we see some strong overlap, weaker associations, and an echodensity measure that is as yet undefined in aging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These methods can be effective whether they are targeted toward substance abuse, disabilities, or HIV/AIDS, whether it is to create changes for individuals in alcohol and substance abuse treatment (citation, 1976), or other clinical setting where bias or discrimination exist (citation, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings imply that enhancing eating competence, especially contextual skills for planning and having regular meals, could promote adherence to a healthy diet and thus, in the long term, also support the prevention of type 2 diabetes. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As early detection of treatable eye disorders has far-reaching benefits for vision and long term health and well-being of the children involved, a comprehensive early childhood vision screening program should be considered in Hawai\u2018i. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ANP has anti-inflammatory and anti-infectious activity on endothelial cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More interventional nutritional studies might be required to quantify the underlying mechanisms by which walnut components influence microbiome composition and how the abundance of butyrate-producing bacteria is increased. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Presumably, a healthier diet and greater physical activity in ECPs could explain the beneficial associations of eating competence with lower BMI and insulin sensitivity, as suggested previously [40,41]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, the model that we suggest is built upon two bases: (i) the planning process is directed toward the parts of the environment\u2019s model that are most likely to benefit from further deliberation, and (ii) the planning process uses \u2018cached\u2019 action values for the unexpanded (i.e., pruned) parts of the tree. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This also allows a better axial preparation of the femoral canal and decreases the risk of varus implantation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, if individuals with TBI complain of balance-related problems, we recommend that they be evaluated not only with the SOT but also with the LOS test, and treated accordingly. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be noted that the observed reduction of BAFF-R in CVID might be an overestimation because BAFF-R expression levels are lower on CD27\u2212 B cells, the predominant B-cell subset in these patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our cohort, unsupervised computational clustering techniques were unable to reveal subgroups of subjects using different combinations of immunological and/or clinical parameters. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Development of a clinical algorithm for neuropathic pain (1997) Surgical interventions for cancer can generate NP(Marchettini, Formaglio, & Lacerenza, 2001; Milch, 2005); its incidence and prevalence in children and adolescents are unknown (Berde, Lebel, & Olsson, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, there are relationship among socioeconomic status, educational level, and city size with prevalence of atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CD133 has been accepted as a cancer initiating cell marker for colon cancer and it has been shown that CD133+ cellular subpopulation could be used as a baseline to sort and detect CTCs in the peripheral blood of CRC patients using FACS. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A single-point change is what differentiates 2 categories, e.g. the difference between no limping and slight limping on the 4-point Likert scale. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The common starting dose for adults is 25 mg orally at bedtime (Dworkin et al., 2003; Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this series, gabapentin has been used in 50.3% of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, some payers will only cover typing for a limited number of donors or will cover only the donor chosen for transplantation-further constraining the number of donors selected for additional testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, an experimental comparison of pre- vs. post-quit attempt actions in tobacco users found post-quit but not pre-quit actions predicted long-term abstinence (Borland, Balmford, & Swift, 2015). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It stands to reason that the two realms of representation, those of the object as object (\u2018a rose is a rose is a rose is a rose\u2019) and those of the word as symbol (\u2018a rose by any other name would smell just as sweet\u2019), are likely to be subserved by two separate and dissociable, though interactive, networks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recently, three papers described the prebiotic properties of other members of the tree nut family in human clinical feeding trials. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surprisingly, in comparison with SOT, more participants were found to have LOS problems, which included a reduced cone of stability in more than half (LOS MXE 58%), increased reaction time (38%), and decreased movement velocity (23%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All patients who experienced complications completely recovered without any severe complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is interesting to note that this second replicated locus lies only 600 kb from that previously identified, also on chromosome 16p11.2, and that both deletions arise de novo with high frequency, probably reflecting general chromosomal instability on chromosome 16p due to the presence of multiple segmental duplications [10], [12], [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A CD4 cell count less than 200 cells/mm3 is classified by WHO as severe immunosuppression 15. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although this represents a small retrospective (selected) series of patients, our data confirm that RTX is effective for treatment of pulmonary granulomas following a prolonged period of B cell depletion. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The nominal associations in whites between rs9331896 (CLU) and reduced risk of decline on the DSST as well as higher scores on a test of verbal memory at baseline that were also identified in the meta-analyses combining race-specific results may suggest that the rate of clearance of amyloid deposits is a physiological mechanism affecting cognitive status as early as middle age. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only one candidate gene-based association study demonstrated a statistical association of rs430397, located in the intron 5 of glucose-regulated protein 78 (GRP78), with HBV-related LC22. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This shift is characterized by an increase in the relative abundance of potentially beneficial butyrate-producing bacteria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accurate built environment measures and development of more precise benchmarks through further research may be needed to assist informed decisions about the planning and design of activity-friendly neighborhoods in India, which may be helpful in improving the long-term health of residents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, increased motor activity, such as our mice experience when performing the Open Field Object Recognition task, has been associated with enrichment effects in the past (van Praag et al, 2000) Increased cognitive performance, despite increased anxiety (indicative of stress) also was associated with enriched early life experiences, such as communal nesting (Branchi, D'Andrea, Sietzema, Fiore, Di Fausto, Aloe, & Alleva, 2006). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another region that showed positive correlation between mean FA and BSID cognitive and language scores is the optic radiation, an important component of the visual pathway. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ROS and MAP are two longitudinal studies of non-demented individuals whose mean age at the baseline examination was 75.5 and 81.0 years, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This association may be due, at least in part, to increased risk of premature birth and low birth weight, both of which adversely affect eye health and processes associated with the normal development of vision 25. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Restriction of the analyses by Dorgan et al (1996) to 46 cases whose blood was collected more than 2 years before diagnosis reduced the odds ratio in the top tertile of the testosterone distribution to 1.3, which was no longer statistically significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies have reported that there is no statistically significant difference in pain intensity after robot-assisted and laparoscopic surgery for gynecologic procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, the discordance between serology and direct detection could be explained by a number of reasons. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence of opioid-related complications and the duration of hospital stay were similar between the 2 groups as well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we did not measure miRNA expression levels by lutein/zeaxanthin intake, our study supports the notion that dietary lutein/zeaxanthin intake impacts DICER1 activity by regulating miRNA expression, thus affecting CRC risk via an underlying interaction between antioxidant effects and miRNA expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to information derived from pharmacological inventory databases, anecdotal evidence and clinical experience, the percentage of patients treated for at least 6 months may be less than 5% (Keller and Boland, 1998). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, the HGPS cohort exhibited mean PWVs of 13.00\u00b13.83 comparable to those of adults over age 60 years.17, 18 Redheuil et al (2010) found that PWVcf increased from 6.2 \u00b1 0.7 m/s at ages 20\u201329 years, to values comparable to our HGPS population at ages 60\u201369 (12.8\u00b13.9) and over 70 (13.8\u00b15.3 m/s), and exhibited a highly significant relationship with aging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DBNDD1 is associated with tanning ability (48) and has been independently associated with squamous cell carcinoma risk (47). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No significant difference between those practising self-medication and those not practising in terms of beliefs in Specific-Concern. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Currently the value of low oxygen concentrations in human IVF laboratories is a continuing question and the effect of low oxygen concentration on human embryo development competence are controversial. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because neuropathic pain is not always satisfactorily treated with gabapentin and TCA, the efficacy of other anticonvulsants such as pregabalin, topiramate, and lamotrigine is under investigation in adults with neuropathic pain and/or postoperative pain (Dahl, Mathiesen, & Moiniche, 2004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are limited number of studies about ACE gene I/D and MTHFR gene C677T polymorphism and osteoarthritis in the literature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After years of efforts, researchers achieve some relative information. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This resulted in shortening of the LOS to 2\u20133 days without increasing readmissions [19,23,24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, this trial was designed to investigate group differences between PA and LA rather than at the individual level, which has been suggested by Katz et al (2015). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chan et al. demonstrated in two-stage chemical carcinogenesis mice models that Stat3 is required for the initiation and progression of skin cancer (49). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It seems that prayer has to be incorporated in the religious meaning system of the patient before it can function as a tool in pain management. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, operation time was prolonged, and errhysis, recovery retardation, infection, and dysfunction of the rectum and bladder occurred after the operation, which further decreased the superiority of laparoscopy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It will be difficult, if not impossible, to adopt additional donor selection procedures to enrich a favorable KIR haplotype donor pool with only a minimal cohort of donors selected in each search for additional genotyping. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This relationship may potentially be explained by BMI tracking, which has been demonstrated from infancy to middle childhood44. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anecdotal evidence from Oxford House leaders, residents, and some of our research team's qualitative work, as stated earlier, suggested that the philosophy of the Oxford House movement might account for this effect in tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This characteristic, however, is not unique to this group of tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several limitations should be pointed out as well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Host genetic factors are widely viewed as the common basis of the different outcomes of HBV infection17,18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Currently, one of the major challenges for whole-heart CMRA is the long scan time and image artifacts caused by motion instability during the long scan time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the case\u2013control study we have shown for the first time that patients with coeliac disease are at increased risk of fracture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the GRS63 was clearly associated with fracture risk in non-BMD adjusted models and marginally associated with fracture risk in BMD-adjusted models, we next evaluated its clinical usefulness for fracture discrimination and reclassification in models with or without BMD included. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, this could be a possible explanation that the detrimental effects of atmospheric oxygen on embryo development were observed obviously on day 3 or blastocyst stage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, older children have less time available for effective treatment and screening should be more sensitive in this age group. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "11 Further adaption of these recommendations will be necessary with increasing knowledge of the disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the loss of significance in adjusted models could be due to the inclusion of car ownership that may be acting as a mediating variable between the built environment and commute mode choices. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They also found a significant difference in the prevalence of the different arch forms among the different Angle classes of malocclusion; Ovoid was the most common in Class I and Class II and square was the most common in Class III malocclusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result clearly reflects the gender role discomfort these individuals experience in terms of their biological sex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Once operative difficulties, mainly on the femoral side, had been successfully overcome, the solid primary fit of both components is impressive even in poor acetabular bone stock. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "S246L also shifts the availability curve to the left (Fig. 5A), but this -7 mV shift alone is clinically silent (unaffected mother and sister), compared with the -10 mV shift purported to cause HypoPP for the R672G/H mutations (28). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In vivo, larazotide inhibited gliadin-induced macrophage accumulation in the intestine and preserved normal TJ structure in gliadin-sensitized HLA-HCD4/DQ8 double-transgenic mice (19). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lack of association in this dataset could be caused by differences in coverage between the two assays used. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Though these explosions are infrequent, in some crematoria there is more than one explosion per year. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A limitation with the present study is that the smaller Gothenburg part (n=942) of MrOS Sweden was included as one of many cohorts in the large (n=50,933) replication phase of the GEFOS meta-analyses and, therefore, only the MrOS US and SOF cohorts are independent samples. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it can be assumed that high compliance also improves outcomes in gastric surgery, but this, however, needs further detailed analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, the participants who were in a lower socioeconomic and educational status were more likely to be aware of BSE, but they doubted their ability to perform BSE properly. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Provision of insurance schemes to the poor should be promoted. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since a structured questionnaire always include a large number of variables which can lead to the problem of multicollinearity, both the consistency of the Lasso method and the traditional Logistic regression as well as the stability verified by simulation experiments in our research showed that it was appropriate for solving that issue and may enhance our ability for mining new information on large epidemiological investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The great variations in the postoperative infection rates revealed in this study are likely related to the time interval between cervical conization and posterior hysterectomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While none of the reported associations retain statistical significance after adjusting for multiple testing, the results of these exploratory analyses warrant further investigation in larger, independent studies of breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABI is a useful tool to detect peripheral vascular disease in the general aging population, where it indicates calcifications or vessel stiffness when high, as well as lower extremity occlusive disease when low 12. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some holes were drilled in the straw board ceiling in 1982 and 1983, which could have provided a point of entry. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strong correlation may have obscured the effects of various cytokines on seminal plasma HIV-1 RNA levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have suggested that remifentanil causes OIH. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings highlight the importance of health promotion in transport industry workplaces, to help drivers make better choices about their health behaviors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most important tools in early diagnosis are the national screening programs. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data do not agree with the results of two previous animal feeding studies demonstrating that walnuts significantly altered the relative abundance of these two major gut bacterial phyla independent of the length of walnut consumption [34,41]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consumers, practitioners, educators, and policy makers at all system levels can benefit from overcoming these many forms of stigma and prejudice because if it was not for attitudes of social exclusion, individuals could act as more full citizens, actively participating in society as workers, parents, and community members (Sayce, 2000, Rutledge & Abell, 2005).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AFI can be financially disastrous to households already afflicted by poverty, and that unmanageable costs begin to accrue early in the patient journey. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is the first to ever examine and report an independent diagnostic and prognostic value of measuring maternal serum NLR for HCA and funisitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results further suggest that body fat plays an important role in moderating this relationship: Shuar children with above-median levels of adiposity who experienced elevated CRP were able to completely avoid the 49% decrease in 1-wk growth faced by thinner children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Greater impairment in naming natural kinds has specifically been attributed to dysfunction of anteromedial temporal cortex because of this area\u2019s special role in fine-grained discriminations of object concepts and the greater importance of fine-grained discriminations for the category of natural kinds where individual members are more confusable (Bright et al, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the largest sample so far in a study examining eating competence and its association with metabolic and lifestyle factors related to the risk of type 2 diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, we investigated whether combined use of CRP level and NLR, measured before treatment, can predict poor pregnancy outcomes in patients with PIR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We considered the detection of caspase-8 and caspase-9 representative of activation of extrinsic and intrinsic pathway, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A limitation of this study is that this was a retrospective analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first trial investigating the long-term prophylactic efficacy of Hypericum extract after recovery from an acute episode of major depression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, patient-specific measures of skeletal muscle area obtained using analytic morphomics were more strongly associated with aminoglycoside pharmacokinetic parameters than were standard measures of body size. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Primary care physicians should educate the public about BSE and other early-diagnostic methods for breast cancer, depending on the age of the patients. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanisms for the association between long sleep duration and increased risk of stroke have not been fully elucidated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, more sophisticated methods developed for aggregating rare sequence variants in the absence of prior information, for instance as implemented in the \u2018thgenetics\u2019 R package [41], might be adapted for use with complex GSVs. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the present study may provide a theoretical basis for the prevention and control of hypertension in the countries including the same ethnicity which share common phenotypes and genotypes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lymphopenia, on the other hand, results from inflammation-induced mechanisms such as impaired antigen presentation, activated negative costimulatory signals, and production of immunosuppressive factors, all of which can contribute to a significant decrease in T-helper lymphocytes [20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of noise did not affect gait speed, which suggests that this intervention was not mediated through differences in speed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the elderly, a reduced cone of stability has serious implications, because it has been linked to increased fall risk 24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neurocognitive test scores and six-year change in scores were evaluated in the ARIC study as a possible endophenotype for the loss of short-term memory and reduced executive function characteristic of AD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides using a well-defined, healthy cohort, we documented and tested several prenatal and postnatal factors for confounding effects on the FA-BSID relationships of interest. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LCGMM allows for greater heterogeneity because of its estimation of within-class variance for each trajectory10, 11. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our investigation is the first to test the potential benefits of progesterone on neuropsychological outcomes in humans sustaining moderate to severe TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current study shows that the left anterior temporal cortex can be added to this list of areas that mediate the search and selection of verbal labels for objects, a processing step that appears closely related to the lemma of lexicosemantic models (Indefrey and Levelt, 2004; Schwartz et al, 2009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A plausible basis for association between FOXP2 variants and obesity is through its involvement in neurodevelopment [28], whose importance in feeding behaviour is well-established [29]; alternatively, an obesity-related phenotype might be independent of effects on FOXP2, and result instead from deletion of a putative NF-\u03baB binding site. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants from all backgrounds recognized the need for help from outside the household early in the course of the AFI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, well planned vaccination strategies implemented during the last decades, together with ongoing Healthcare Surveillance Programs, largely contributed to the control of HBV infection and its associated complications in Italy, both in the community and in several occupational settings at high-risk, particularly the healthcare one, optimizing the primary prevention of this serious biological agent. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This procedure has the advantages of reducing trauma and accelerating postoperative recovery [19], and it is becoming increasingly popular [20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Again, serial bone density measurements showed major improvements in bone mineral density after treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the evidence generated thus far, some ambiguity remains in the association between access to food outlets selling ready-to-eat or take-away foods and cardiovascular risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A study conducted in women aged 20 to 60 years having a breast cancer family anamnesis and high level education, increase in the percentage of women practicing BSE (Altunkan et al, 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The genomes obtained from isolates from swine (n = 2), poultry (n = 2), and air from poultry houses (n = 2) were all located in the nonresistant clades A/H53 and B1/H24 (Fig. 3), whereas the genomes obtained from sewage and from a dog were both located in the B3/H24Rx cluster. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With a longer follow up, McCarthy et al. [21] found a 40% loss in average bone mineral content proximally around cemented femoral stems at 7 to 14 years after operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Amodality versus domain specificity at the tip of the left temporal lobe The concept of an \u2018amodal semantic hub\u2019 located at the anterior temporal lobe has received a great deal of attention in the recent literature on semantic dementia and has shaped current thinking on how knowledge might be organized in the brain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is counter to the hypothesis that one route of infection of TB in field voles is via skin abrasions caused by aggressive encounters, as might be expected based on the appearance of cutaneous lesions, and which would be expected to be more prevalent in males due to their more aggressive nature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed differences by age group are harder to interpret. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, our findings are in line with previous research by confirming an association between the SOT and DHI in patients with TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The literature shows contradictory results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it is notewortlhy thalt blood0 requiremiients were low in all groups, presumably due to the restrictive incications for postoperative blood transfusions establishecl by the stucly protocol. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although not directly comparable, Bacillus anthracis and Clostridium tetani spores are known to survive for many years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This warrants further study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, novel findings of the study are that f) most users did not prepare ahead of time before their quit attempt; g) tobacco use and alcohol use were less common on days of cannabis abstinence than on days of cannabis use; h) symptoms of withdrawal occurred even with short quit attempts; i) abstinence and reduction predicted decreases in cannabis dependence; and j) planning activities during the quit attempt predicted greater abstinence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Missing data are not unexpected in large trials because participants may freely choose not to complete questionnaires, and researchers may fail to collect certain measures because of time constraints, patient fatigue, or other scheduling issues. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, contrast-enhanced whole-heart CMRA at 3.0T can depict the normal and variant cardiac venous anatomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Numerous biologic therapies have also been evaluated for refractory (most often defined as progressive disease unresponsive to conventional therapy, such as glucocorticoids and cyclophosphamide) and persistent disease.6 While cohort studies outline the use of deoxyspergualin, anti-thymocyte globulin, and TNF-alpha antagnosists, there is a greater level of evidence supporting the use of intravenous immunoglobulin and RTX for refractory and persistent disease1,30\u201334. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Computed tomography or magnetic resonance imaging are not only helpful in demonstrating the extent of bone destruction but are also of great importance in diagnosing primary lesions [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, ZO-1 protein expression was generally lower in HLA-DQ2/8-positive patients (borderline in SB and significant in rectosigmoid mucosa). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We investigated the performance of the CDI in-line blood gas monitor with and without the recommended gas calibration prior to use, with regard to the three parameters pH, pCO2, and pO2, compared to our standard, the ABL 800 flex, and found that without gas calibration and before in-vivo calibration, the CDI estimates were inaccurate and imprecise for pH and pCO2 when compared to the calibrated measurement series. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this functionality appeared to be only partially preserved, as it could not support the computationally far more demanding task of searching the vast internal thesaurus [this term is used instead of \u2018lexicon\u2019, in keeping with the usage introduced by Warrington (1975)] and selecting the correct noun for subsequent phonological encoding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, videofluorography can be a useful tool for assessment of rat deglutition for research purposes. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cortinez et al revealed that intraoperative continuous remifentanil infusion (0.25\u200a\u03bcg/kg/min) during gynecological surgery did not increase postoperative morphine consumption during the first 24\u200ahours, compared to sevoflurane based anesthesia without remifentanil infusion15. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "5\u201310% of breast cancer cases are identified through physical examination without any requirement to perform mammography. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In one of his studies, for example, higher levels of self-esteem were found for adults who believed that only God knows when and how prayers should be answered than for adults who expected prayers to be answered immediately. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With information obtained from this study, it is possible that neuroimaging in newborns may to some extent predict neurodevelopment even for healthy children, and prenatal intervention targeted at improving white matter integrity at birth will be important for further promoting neurodevelopment in children. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At room temperature these devices are benign. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By including both pulsatile and continuous intravenous cortisol feedback under both low and high systemic E2 (in women) and T (in men) concentrations, the present analyses demonstrate strong inhibitory effects of E2 but not T on ACTH concentrations, pulsatile ACTH secretion, and ACTH ApEn (secretory-pattern orderliness) in healthy older adults. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be very challenging to extrapolate from the results of in vitro model back to the biology of the intact organism as a whole. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study investigated the relationship between level of stress and atopic dermatitis in Korean adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Without effective intervention, the burden of hypertension will only exacerbate the epidemic of cardiovascular and kidney diseases, especially in Uygur, Mongolian, and Kazakh populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "S1B in the supplemental material). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The major assets of the study are a) the inclusion of a large sample of non-treatment seeking, daily, cannabis users; b) the collection of prospective, daily data on attempts to change; and c) high compliance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results disagree with the findings of Murshid,39 who found that the most common arch form was the ovoid arch form in both males and female. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All of these disorders are inherited as dominant traits, and the mutant channels are functional, albeit with altered gating behavior. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Importantly, targeted therapy with TLR agonists has been used to treat melanoma (54,55). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether elevated antiphospholipid antibodies play a role in the pathogenesis of COVID-19-associated thromboembolic complications and coagulation activation 34 35 warrants further investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measuring arch dimensions and determining arch forms before orthodontic treatment are essential steps for proper diagnosis, treatment planning, treatment strategy, and post-treatment stability 7-9. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We studied genetic polymorphisms of two integral red blood cell membrane proteins that have reached a high frequency in malaria endemic regions of Papua New Guinea. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study might help in better detecting the important risk factors and also indicated that adjusting sleep habits especially reducing the frequency of snorting/gasping may be considered as an effective intervention strategy to weaken the risk of stroke. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A future multicenter non-inferiority RCT would be valuable to investigate whether there are signifi cant differences in revision rates between THAs performed with the LA and with the PA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is worth mentioning that differences can also result from the manner in which the complications were reported. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When the temperature of the liquid is lowered, the solubility of the gas in the liquid increases, and the partial pressure of the gas in the liquid will decrease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although preceding prospective studies demonstrated adverse health outcomes of daytime napping28, our result is consistent with physiological data from short-term laboratory studies concerning the beneficial effects of daytime napping on psychomotor vigilance task, daytime sleepiness, and neurobehavioral performance29,30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, attenuation artifacts are at least as severe with Anger cameras as with CZT cameras (1) and, to date, are far from being fully prevented or detected by the various methodologies and strategies elaborated for this purpose (2\u201315). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is no question that the efficacy of RTX on granulomatous lesions in GPA has not always been apparent,9,11 and it is clear that granulomatous features respond less rapidly than vasculitis features12. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, volatile maintenance anesthesia without remifentanil infusion may represent a good choice for minor operations. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In sum, we proposed a principled algorithm for pruning in a plan-until-heuristic scheme. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They can withstand pressures of up to 20,000 lb/in2, elevated temperatures, desiccation, osmotic shock, UV light, and chemical disinfectants (18). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our intervention incorporated many evidence-based interpersonal and intrapersonal components that should have addressed these barriers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite considerable challenges that face the interpretation of clinicoanatomical correlations in neurodegenerative diseases, the current results suggest that at least parts of the left anterior temporal neocortex should be inserted into the temporosylvian language network where they are likely to play critical roles in linking words to their object referents and in sharpening the taxonomic acuity of naming and word comprehension.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PCA pumps were initiated at St. Jude in 1989. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results presented support the notion of a complex basis of CVID and related milder PAD disorders, in which an accumulation of multiple genetic and/or environmental factors contributes to the final phenotype.3,15,16 Monogenic defects have only been identified in a minority of cases with CVID.14 Remarkably, some relatives with the same monogenic defect were found to be asymptomatic or suffer from a milder PAD phenotype such as IgGSD 20\u201323. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, the parkinsonian rats also demonstrated aberrant tongue movements to process the bolus significantly more than both the young adult and old groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of particularly interest will be behavioral changes and morphological alterations of relevance to mental health disorders such as depression, autism and schizophrenia (Courchesne, Pierce, Schumann, Redcay, Buckwalter, Kennedy, & Morgan, 2007; Eastwood, 2004; Kalia, 2005; Kinney et al 2008; Rapoport, Addington, Frangou, & Psych, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, patients prefer an early solid diet rather than a liquid oral diet. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As indicated above, mechanisms associated with these cortical changes may have significance for the further understanding of and subsequent therapeutic approaches to a number of different mental health disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The enhanced inactivation of V1442E can be explained by a mutation-induced bias in the voltage-dependent motion of IV/S4 toward the outward conformation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although Park (2006) focuses on other personal aspects of religion (e.g., intrinsic religiousness), it is likely that the same underlying mechanism is present in the relation between prayer and pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, younger age was associated with worse general QoL, while there was no significant difference in general QoL between female and male participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This methodology, once validated in further studies, may be particularly valuable in important patient subpopulations in which empirical dose decisions are especially challenging, such as frail or nonambulatory patient populations with very low serum creatinine values and corresponding uncertainty in estimated creatinine clearance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This inflammation-tradeoff hypothesis for explaining the dual burden paradox is supported by several lines of evidence, including the ubiquity of recurrent inflammation among children in the developing world (16), the increased deposition of immunologically important central body fat (56) during both chronic inflammation and stunting (51, 57), and the negative effect of proinflammatory cytokines on circulating levels of insulin-like growth factor-1 (58), itself critical in promoting fat oxidation (59). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results provide potentially useful information of postoperative pain characteristics in the 2 surgical methods.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential interaction between gliadin and HLA genotype is being assessed in a randomized, controlled trial of gluten-containing vs. gluten-free diets (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The short chain fatty acid butyrate may beneficially affect metabolic and inflammatory processes and, thus, obesity, diabetes and inflammatory bowel diseases [36,37]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is also difficult to repeat the scan in the same imaging session if the acquisition is aborted or image quality is suboptimal [13]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aldosterone-induced renal injury has been demonstrated in previous clinical study that a mineralocorticoid receptor inhibitor reduced albuminuria independent of blood pressure reduction [27-29]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This dual burden of poor childhood growth and adult obesity is thought by some to reflect an adaptive adjustment early in life to a \u201cthrifty\u201d metabolic phenotype that promotes fat accumulation to hedge against future energy deficits (17, 53, 55). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Standardizing laboratory techniques has been the focus of working groups such as the Semen Best Practices Working Group at the National Institutes of Health, and will provide much needed guidance for future studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evidence in favor of immunogenetic mechanisms include the observation that, in HLA-DQ8 transgenic mice sensitized to gluten, gliadin exposure led to increased contraction of smooth muscle to electrical field stimulation and carbachol (35). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wan and coworkers in 2003 showed that the mechanisms of tissue injury related to systemic disorders, such as sepsis, seem to be related to a direct activity induced by circulating mediators with both pro- and anti-inflammatory properties able to interact in a dynamic manner and to induce multiple organ failure [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the primary aldosteronism patients accompanying chronic Kidney disease still have been demonstrated high serum aldosterone and ARR levels, low PRA, and no clear association of hypokalemia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As with our STR-B males, the cryo-anesthesia exposed rats used by Kolb & Cioe were behaviorally tested prior to euthanasia for histological assessments. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that transesophageal echocardiography can provide useful information for medical management and surgical intervention of intracardiac tumors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study confirm previous findings on efficacy of other modified pollen allergen extracts [8,25], because highly significant increases in pellitory pollen allergen-specific IgG and IgG4 antibody concentrations were measured after just 1 year of treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be noted that early Ig replacement therapy might interfere with the natural progression of the disease. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, the most prevalent arch form in this Saudi sample was the narrow tapered form, followed by the narrow ovoid form. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intervention strategy that we evaluated was highly effective overall as previously reported and intervention effectiveness did not vary in most of the subgroups we examined for this analysis[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Few studies have explored the association of neighborhood food environments with diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on these findings, two genetic risk scores (GRS63 and GRS16) were developed (15). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicians often follow a \u201crule-of-thumb\u201d method, in which excessive growth is indicated by crossing major percentile lines on a standard growth chart38. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, increased PWV is predictive of subsequent cardiovascular events. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For these reasons, generalizability of findings to settings beyond Australia may be limited. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No specific long-acting opioid has been conclusively shown to be superior for treating chronic pain (Chou, Clark, & Helfand, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-verbal object associations appeared relatively spared. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results and those of previous studies suggest that SNPs and point mutations in those gene regions contribute to melanoma tumorigenesis (56). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only minor improvements in C-statistics (AUC) for all fractures were seen when the GRS63 was added to a base model including age, weight and height but not BMD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Slow growth and resultant small body size during development may reduce the risk of starvation by lowering somatic maintenance costs (68). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, future studies will also have to investigate how changes in cortical morphology and plasticity may be related to specific endocrine alterations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Truck drivers have poor healthy eating and physical activity behaviors and high BMIs, largely due to the limitations of their work environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Embryos cultured in a high oxygen concentration had fewer cells, perturbed cell signaling and abnormal energy metabolism, indicating a cultured environment-induced differential expression pattern [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that ECPs had smaller BMI and waist circumference than NECPs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The inheritance pattern for this case of congenital myasthenic syndrome cannot be unambiguously established. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge there are no data on rates of visual problems by ethnic populations among pre-school children in Hawai\u2018i. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anomias caused by pure retrieval failures We used a particularly rigorous definition of retrieval anomia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should improve upon these methodological flaws. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, EIT electrodes were placed around the thorax at the level of the xiphoid process, due to its good approximation of global lung behavior18 and due to its avoidance of imaging potential organ movements below the diaphragm[Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, we only revealed correlations between early neuroimaging and later neurodevelopment but did not test the predictive ability of early neuroimaging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nowadays, genes regulating the heart development include 4 types: signal, cell adhesion, ion channels molecules and transcription factor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings in IPH and IgGSD patients are compatible with previous published information on milder forms of PAD.9,10,40,41 IPH and IgGSD patients showed an abnormal distribution of na\u00efve and memory B- and T-cell subsets, similar to that observed in CVID patients, albeit to a lesser extent with a block later in B-cell development and a less pronounced T-cell skewing towards memory subsets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Expenses usually rise steeply after admission, and families face the added burdens of time away from work and accommodation far from home for those who accompany the patient [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Abnormal miRNA expression is suspected to promote cellular carcinoma by affecting proliferation, apoptosis, mitosis, and cell-cycle progression46,47. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Proinflammatory cytokines, such as TNF-\u03b1, IL-6, and HMGB1, play important roles in the occurrence and development of biological injury and pathological inflammation processes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should also focus on various food environment measures to shed light on the causal pathways by which food environment impacts on cardiovascular risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The quantitative histological data pertaining to SB CD3, CD8, and (tryptase-positive) mast cells (no.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cortisol responses of young men are more pronounced than are those of young women after psychological stress [29]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was only one cognitive test used to assess each cognitive domain, and the tests were administered at a stage of life at which most individuals would not have experienced extensive cognitive decline particularly during the relatively short 6-year follow-up period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We should also note the absence of ethnic minority status. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When considered together with E2 under pulsatile cortisol feedback, T opposed several of the main negative effects of E2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lack of a correlation between measures of body weight or morphomic measures and aminoglycoside volume of distribution in this study is concerning, given that aminoglycoside doses are frequently calculated to target a specific maximum concentration of drug in serum (Cmax) using weight-based doses and weight-based estimates of volume. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, these kinds of mechanisms are only identifiable in longitudinal studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, strong support from close friends was associated with lower symptoms of social anxiety among adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This point was anecdotally illustrated by a patient with semantic PPA who was visited at her home and found capable of making appropriate use of objects similar to those she could not name or define during her clinical evaluation (Mesulam et al, 2009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, this group likely did not receive the same additional attention that patients with diabetes received. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The side effects of both medications are minimized by starting at a low dosage and increasing the dose every 3 to 5 days until pain relief is achieved or the maximum dose is reached. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The precise mechanisms responsible for the therapeutic effects of SIT remain a matter of research. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inaccuracy in GSV calling, with an appreciable frequency of both false positive and false negative calls, results in inflated P-values and an increased rate of false-positive associations (Text S2; Figure S4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Yet the costs and added value of large scale donor KIR genotyping would need to be acknowledged and shared amongst the Networks of Donor Centers and their Transplant Center customers. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Isolates within these two PO10s were collected from patients within the same region. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has several strengths. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, apparent seasonality in TB prevalence actually reflected differences in the proportion of older animals present in the population, reaching up to 13\u00b72% in March 2002. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many of the tests were also the same ones recommended by expert panels 7,10,11. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Secondly, the coroner's form E does not contain the statutory pacemaker question. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of vole TB averaged 3\u00b787% from the longitudinal study, and 9\u00b709% from the cross-sectional study at Kielder Forest. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The morphological effect that was selective to STR-B mice in our study and most closely corresponded to the baseline corticosterone levels at PND 7, was the significant decrease in cortical layers II/III thickness, following adult behavioral experience. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While interpreting the results, this should be considered, especially given that the association of emotion dysregulation (goal difficulties, impulse and limited strategies), dispositional mindfulness (observing and nonjudge) and social support source (classmates, parents and teachers) with social anxiety symptoms in the multiple regression models was small. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, a very small sample of subjects resulted \u201cnon-responder\u201d to HBV vaccination after the completion of the second immunization cycle (data not showed). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No cats or other animals had been identified in or around the building for several years preceding the outbreak. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study identified deficits in the LOS and SOT tests among our cohort, who were predominantly classified with mild to moderate TBI, and were found to be at chronic stages post-injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, unless a mechanism exists to repeatedly reaerosolize the source, fomites are likely to pose a risk even when they are not heavily contaminated, and this view is supported by the general principles that govern the dispersion and settling out of dust particles or sporelike forms (17,37). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither straw nor building material is a common source of outbreaks of Q fever. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the absence of confirmed VTE or ECMO therapy, anticoagulation at treatment dosages can currently not be recommended on a routine basis. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of this test on transsexual populations relies on: i) the availability of both female and male norms, ii) the identification of response distortion from the 3 validity scales, and iii) the availability of a specific Masculinity/Femininity clinical scale, which is especially pertinent to the assessment of transgender individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we did not find differences in the FEV1/FVC and DLCO between the oxandrolone-treated group and the control group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another potential explanation is that aberrant methylation associated with age at menarche is unrelated to the methylation changes relevant to breast cancer, or that the association with age at menarche is in fact confounded by other determinants of methylation levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our finding that ANP has anti-inflammatory action (i.e., suppression of LPS-induced E-selectin) in vascular endothelial cells in mice is consistent with these studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it is also possible that some important changes taking place in early life and which are associated with age at menarche \u2013 in particular nutrition \u2013 have a detectable effect on methylation levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recently reported a lower blood requirement per patient (7 units vs 14 units)3 after using a series of blood-saving techniques. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is important because increased BMI and waist circumference are the most important risk factors for type 2 diabetes [35,36,37]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patel et al found that density of full service and fast food restaurants within 1000\u202fm buffer was not related with overweight/obese in Delhi, India (Patel et al, 2017). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Phosphoinositide 3\u200akinase/protein kinase B pathway is a key regulator in which mesoblastema, original cells of heart development in embryo stage, specially express transcription factors in heart[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The proportion of ECPs in the current study was lower than among Spanish elderly individuals with increased risk for cardiovascular diseases [10], US adults who were mostly females and well educated [6] and among US adults who had hypercholesterolemia [9]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Had these cases been re-classified, the assessment of the primary outcome measures would have been unchanged. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cardboard manufactured by the factory was produced at temperatures that made survival of C. burnetii sporelike forms impossible so customers were not considered to be at increased risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Granulomata consist of neutrophils, giant cells, monocyte-derived tissue macrophages, B cells and CD4+CD28\u2212 T cells.18 The activation of T cells in an unbalanced Th1 phenotype and maturation of dendritic cells by PR3, exaggerating this Th1 response, have previously highlighted Th1 cells as critical mediators of granuloma pathogenesis in GPA.18,19 Indeed, both CD4+ Th1 and Th17 cells have been implicated as important orchestrators of granulomatous inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A growing body of research indicates that immune-mediated, inflammatory, and apoptotic mechanisms may play a role in the pathogenesis of CRS Type 5 [14]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a clear need for public health professionals to work closely with other disciplines on research, policy, and practice that will lead to joint efforts to meet societal needs. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eight of the children with a \u201crefer\u201d recommendation had bilateral ametropic risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data on these variables were unavailable or inaccurate, and therefore they were not included in the model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Actually, ARR as screening test in primary aldosteronism is suffering great challenges, the influence not only comes from inherence, but also exterior has been verified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A second additional property of the biker position, also likely to enhance spatial resolution, is a lower heart-to-detector distance (18 cm, on average), when compared with the 2 other patient positions (20 cm, on average). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Test results of environmental samples in this outbreak were, however, negative. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent studies have shown that cross-talk between E-selectin and integrins could facilitate the movement of not only inflammatory cells but also tumor cells through the endothelium to inflammatory foci (16\u201318). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Different ethnic groups have different genetic backgrounds and enduring lifestyles which are associated with hypertension [11,29,30]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall results of our analyses suggest that the TSP-based approach can be used to identify predictors of prostate cancer progression. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a review of self-help literature, transtheoretical processes such as self-reevaluation, environmental reevaluation, social and self liberation, and emotional factors may be developed within self-help models and are likely to even be more effective in 24-hour self-help living than they are in weekly groups (Olson et al, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results for the gas calibrated CDI correspond with the results found by Southworth et al. (7) for pH and pCO2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In their study, layers II/III, also were prominently decreased in thickness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed ethnic-specific differences and several factors predictive of the BMIz trajectories. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, we found an enrichment of members of the genus Ruminococcaceae spp. and Bifidobacteriaceae spp. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study showed an association between dietary lutein/zeaxanthin intake and CRC risk among those with the DICER1 rs3742330 genotype in a Korean population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparison with Other Studies To our knowledge, CDI estimates with and without calibration have not been previously compared. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Heart is the first organ to form in the process of embryogenesis and its development is a extremely complicated work, referring to the expression of multiple different genes in specific period and the proliferation, differentiation, migration of cells[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These authors reported that NGAL measurements at admission did not predict worsening of renal function (WRF); on the contrary, several measurements of this marker in the first day of hospitalization can accurately predict WRF [15]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In studies from LMICs like Mexico, Colombia, and Nigeria, car ownership was negatively associated with transport-based activity levels\u2014higher levels of transport-based activity levels tended to occur in the non-vehicle owners, and may be strongly driven by necessity [57,59,72]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we found no association between access to highly processed and take-away food vendors with fasting glucose or insulin, consistent with a recent systematic review that found no convincing evidence for an association between food environments and type 2 diabetes (den Braver et al, 2018). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Historical changes in pain management strategies at St. Jude (1981 to 2007) Over the years, clinicians at St. Jude have come to understand that PPLS represents a complex pain syndrome of mixed nociceptive and neuropathic pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we showed that the expression levels of TNF-\u03b1, IL-6, and HMGB1 in cervical tissue and secretions gradually increased after conization, peaked after approximately 1\u20132 weeks, and then 3\u20136 weeks onwards following surgery, significantly decreased to the preoperative levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A strength of this research is our investigation of four sensitive immune biomarkers, each quantifying functionally distinct, low levels of immune activity that, while metabolically costly, likely do not result in anorexia, physical inactivity, or other energetically relevant symptoms of infection (35, 41) that could obscure tradeoff relationships. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, boys who resided in large cities and mid-sizes cities were more likely to report having been diagnosed with severe atopic dermatitis than were those living in small cities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results, coupled with other correlational and quasiexperimental results, stress the importance of providing high quality evidenced-based reading instruction throughout the early grades. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, due to the retrospective nature of our current analyses, we could not control the use of pre-emptive antiemetics by some of the surgeons, which might have affected the PONV incidence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As compared to intermittent IV doses, epidural analgesia can provide greater overall comfort with lower pain scores, less muscle spasm, and greater tolerance of physical activity during the initial postoperative period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was concluded that almonds and especially pistachios can affect the composition of the fecal bacterial microbiota [43]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angle pointed out the arch form in his classification as the line of occlusion, which he considered as an important criterion for ideal occlusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our prospective non-blinded trial involving sibling oocytes showed no significant difference in the fertilization and cleavage rates in the first two cleavage divisions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This criterion was applied to increase the quality of the phamarmacokinetic parameter estimates; however, it may have led to the exclusion of relevant patient populations receiving empirical therapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In further support of this second-hit model, our in vivo data demonstrate that while Abca1 knockout mice are not albuminuric at baseline, they are more susceptible to TNF-induced albuminuria (Figure 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, empirical assessment of CL will be critical to attaining safe and effective drug exposure with plazomicin and other novel compounds within this class in early clinical use while awaiting the results of send-out samples for concentration measurement. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One may argue that discrepant observations in North-European and Eastern-European populations may be due to different ethnic background. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, even limited contact of smokers with cessation counseling doubles the odds of quitting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Susceptible ARR should be limited diuretic at the least for screening test [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In china, it is uncommon to perform fresh BT cycles for each patient and all available fresh blastocysts would be cryopreserved for transfer in a subsequent cycle. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLU encodes an apolipoprotein that is highly expressed in the brain, and is present in amyloid plaques and cerebrospinal fluid from individuals with AD [Calero et al  2000; Liang et al  2008; McGeer et al  1992; Roheim et al  1979]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previously, cellular subpopulations from tumor tissue such as CD54+CD44+ 18, CD26+ 27, CD133+CD44+ 28, and CD133+CXCR4+ 29 had been sorted and identified as CICs or MICs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Together, our data suggest that a broader impairment of the immune system, including alterations in co-stimulatory molecules, lymphocyte trafficking and innate immune cells, is required to develop a clinical phenotype. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contrary to other studies25, we found worse psychological functioning in the MtFs with a same-biological sexual orientation in comparison with other cases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More importantly, Kazakh ethnicity is mainly distributed in Kazakhstan, Uzbekistan, Russia, and China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, multiple statistical tests were performed without adjustment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important, therefore, to analyze where healthcare is sought, and what routes patients follow when an illness progresses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Perspectives and Significance The present combined models of sex-steroid and cortisol addback clamps unmask consistently negative effects of E2 in older humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study supports the concept that mechanical noise may improve gait dynamics in individuals at high risk of falls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the true amount of refractive error and diagnosis of amblyopia can only be determined after a cycloplegic eye examination and evaluation by an eye care professional. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study has some limitations which should be taken into account when interpreting the results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, non-invasive carotid artery ultrasonography is subject to technical limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the course of PEEP titration, oxygenation in the PEEP-ventilated patients improved in some specific levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The anticonvulsant gabapentin emerged in 1993 and proved useful for the treatment of NP in adults and children (McClain & Ennevor, 2000), including postherpetic neuralgia, diabetic neuropathy (Bone, Critchley, & Buggy, 2002; Dahl, Mathiesen, & Moiniche, 2004; Gilron et al., 2005) and post-mastectomy pain (Dirks et al., 2002; Fassoulaki, Triga, Melemeni, & Sarantopoulos, 2005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That study also found that the difference in mean score between patients with and without self-reported limping ranged from 17 to 35 on the 5 HOOS subscales, in favor of the non-limping patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In support of this explanation, also a recent study investigating a spectrum of chemokine polymorphisms in non-Caucasian (Korean) population [2] included more SSc patients than the original German study [13] and similar to us, no relationship between the MCP-1 A/G SNP and disease in Koreans was observed [2]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bleeding risk and potential pharmacological interactions with other medications in patients with multiple comorbidities must be considered. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results also suggest that lung function should not be looked at simply with static tests such as the pulmonary function tests, but also with dynamic tests performed during exercise. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results are comparable to previous Australian and international research 4,11. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study limitations included a small sample size that may have resulted in a lack of correlations with the main functional pathways, and the use of a 1.5-T MRI scanner and a small number of diffusion directions, which limited diffusion models that can be tested but should be adequate for evaluating FA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In spite of the available evidence, primary and secondary prevention of schizophrenia, a disorder entailing many years of life in disability, is still being neglected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Within the C/H30 lineage, the C1/H30R clade, possessing fluoroquinolone resistance conferred by mutations in the chromosomal genes gyrA and parC, and the C2/H30Rx clade, which in addition is associated with carriage of blaCTX-M-15, emerged around 1987 (3, 4, 22, 23). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Snorting/gasping, snoring frequency, lack of daytime napping, and long sleep duration are statistically significant independent risk factors for stroke and its subtypes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, the median duration of the preoperative antibiotic therapy was 7.5 months, which was shorter than in previous studies (14-18). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, although diet-induced shifts in the gut microbiota occur within a short period of time (between 1\u20134 days after a change in diet), these changes have been shown to be reversed just as rapidly [19,20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to SSFP, spoiled gradient-echo imaging (e.g., FLASH) is less sensitive to static and RF field inhomogeneities, and results in more consistent image quality among subjects at 3.0T. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Per the State-by-State Vision Screening Requirements posted on the website by the AAPOS (updated in 2011),39 Hawai\u2018i has no state policy on early childhood vision screening despite the report to the 24th legislature, State of Hawai\u2018i, 2008 prepared by the Department of Health which mentions improving vision screening for preschool and school-aged children as an area for further action 40. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Animals or animal products had not been moved through the docks in recent years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, we found that his inclusion in the study did not clhange the results of the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our overall assessment is that the significant association between HLA genotype and overall colonic transit may be a chance finding and requires replication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Those top interferon (IFN)-alpha genes play roles in the immune system and cytokine signaling. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, our results show that mechanical irritation of the tissue by the dorsal instruments results in a higher risk of developing infection or a fistula. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study has limitations typical of a single-center study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contrary to our hypotheses, no statistically signifi cant difference in improvement in physical function was observed between the patients in the 2 groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparable results have been demonstrated by another human feeding trial with a similar initial hypothesis but over a much shorter intervention period of only 18 days. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical studies of NP should evaluate not only pain scores but also the descriptors of pain that are highly correlated with neuropathic pain conditions: electric shock, burning, cold, pricking, tingling, and itching (Bennett, 2001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The limited number of studies on how to interpret phylogenetic relatedness based on SNP differences in E. coli makes it difficult to give a generic threshold on how to distinguish clones from local or regional outbreaks when epidemiological data are not available (17,\u201319). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Straw is an increasingly popular ecologically friendly material, and >350,000 houses have been built in the United Kingdom with this particular type for straw board as internal partitions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Masculinity/Femininity scale may be considered a reflection of the gender role dysphoria of these individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, this case-control study performed in Slovak population does not provide further evidence for recently formulated concept that MCP-1 \u22122518 A/G SNP is involved in the genetic predisposition to systemic sclerosis as a whole. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the associations of eating competence with new type 2 diabetes or insulin sensitivity were at least partly mediated by BMI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The fact that this occurs irrespectively of sera TNF levels challenges the idea of using circulating TNF, TNFR1, and TNFR2 for the implementation of patient-specific targeted therapies. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Studies have used various methods to quantify the food environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, patients who were treated with three or more classes of antihypertensive medication classes and had persistently elevated BP were more likely to have resistant hypertension or other management challenges. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A major risk factor for breast cancer is the long-term exposure of breast tissue to estrogen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, comprehensive epidemiological data with travel information are needed on a global scale to clarify the actual route of transmission. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we found that intraoperative remifentanil infusion increased the postoperative pain intensity on the day of surgery which required rescue analgesics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, our study focused especially on frequency of prayer whereas some recent research indicates that other aspects of prayer are important as well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, Sapone et al. (30) reported decreased intestinal permeability in patients with nonceliac gluten sensitivity; it is worth noting that the patients included in our study were not selected on the basis of gluten sensitivity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We presume that our selection of a mouse strain with high reactivity to environmental factors is largely responsible for the magnitude of changes we report here. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, evidence has shown that the interaction between DICER1 and CRC demonstrates the importance of miRNA-related SNPs (miR-SNPs), which alter miRNA levels and thereby influence mRNA transcription, in DICER. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This group of experts influenced the evolution of pain management for all St Jude patients through policies, procedures, and standards of care. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These may include patients previously treated with antibiotics and patients with upper genital tract infection 4, 8, 9. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thrombocytopenia and/or a prolonged APTT or PT without clinical signs of bleeding are per se no contraindications for pharmacological VTE prophylaxis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Duplications of a region lying between the KIF2B and TOM1L1 genes showed marginal association with increased BMI, consistent with the original report [16]; there is at present no readily apparent functional basis for this putative association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Current fracture risk prediction tools are based on clinical risk factors with or without BMD measurements. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maternal smoking during pregnancy was not included as a predictor, owing to low prevalence in our study sample (2%), but was unrelated to child adiposity in previous analyses45. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Though insulin resistance and increased BP may have some contribution to increased PWV in our HGPS cohort, as they do in nonHGPS patients with diabetes and hypertension29\u201331, only chronologic aging is independently associated with the degree of PWV elevations that we detect in HGPS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given national policy and media attention regarding teacher accountability, the current findings bear direct relevance to the discussion of teacher value-added scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ten patients in particular had IgG titers to C. trachomatis of only 1:64, and it is difficult to interpret these results without clinical correlation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support this hypothesis; however, as national surveillance programs monitor only local epidemiology, global surveillance is required to follow the dissemination of pandemic clones. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that serum oestradiol concentrations in postmenopausal women may be a strong predictor of the subsequent risk of developing breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In studies using 16-slice or 64-slice MSCT, the prevalence of the PIV varied between 99 and 100%, the prevalence of the PVLV between 82 and 96%, and the prevalence of the LMV between 27 and 71% [4, 5]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The safety of SIT with modified allergenic extracts using standard schedule has been documented on grass, weed and tree pollens and house-dust mites [6,23\u201326]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results are consistent with our clinical experience and underline the fact that, contrary to the formerly widespread opinion, transsexuals do not have significant psychological disorders, and their demands for sex reassignment surgery are not symptoms of psychopathology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, hypoxia, a component of chronic synovial inflammation, has been shown to stimulate angiogenin mRNA expression and protein release [45,46]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replication in additional population-based samples with participants drawn from a range of different age and ethnic groups will be required to confirm and extend these observations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Any activities that involve leaning, bending over, or reaching can become more difficult for those who have reduced limits of stability 13. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As previously mentioned, our subjects did not fully comply with the recommended diet (i.e., substitution of carbohydrates or fat or both for walnuts), indicating that subjects had a similar diet, despite different recommendations [9]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That problem is expected to be most severe when the sample size is small and the number of probes is large, as they are in a typical microarray design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contrary to reduced pharyngeal transit time observed in humans with Parkinson disease, the parkinsonian rats did not demonstrate slower bolus speeds [35, 37]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This latter observation may clarify the mixed results of previous studies, which have reported relationships between immune biomarkers and child growth in some cases (e.g., refs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measuring waist circumference particularly indicates abdominal obesity, and waist circumference may be even a better predictor of type 2 diabetes risk than BMI [38]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In animals both neonatal and adult sex-steroid exposure can alter sexual dimorphism of ACTH regulation (24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The MMPI-2 was a major revision of the MMPI23 and was standardized on a new large national sample of adults in the United States. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results are in line with those from a cohort study that found twice as many patients in the LA group with self-reported limping at 1\u20133 years postoperatively (Amlie et al 2014). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among these, grade 3/4 neutropenia and elevation of liver enzymes are reported as the most common toxicities related to dose delay. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While CVID has been studied in depth over the past four decades, there are few immunophenotypic reports on milder forms of PAD, such as IPH and IgGSD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, we showed a marked proapoptotic activity trigged by both intrinsic and extrinsic pathways in RTCs incubated with plasma from CRS Type 5 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Studies from the US report that the BMI in US drivers ranges from 30.0 to 34.5 kg/m2, which is consistent with our findings 5,6. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Another limitation is that our data collection of repetitive brain injuries was subject to recall bias based on patient self-report of their past history, and may not be as reliable as tracking a brain injury prospectively with a validated instrument.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither the behavioral profiles of STR nor LMC males are fully consistent with the enrichment literature, typically characterized by improved cognitive performance (compare: Hohmann et al 2011a; Rosenzweig & Bennet, 1996). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Clinical Features Herald a Myasthenic Phenotype. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite this uncertainty, this report clearly establishes a congenital myasthenic syndrome as a new allelic disorder to be grouped with the myotonias and periodic paralyses previously attributed to mutations in Nav1.4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While patients receiving epidural analgesia post-LSS were initially managed in the ICU, they are now safely managed in non-ICU areas with frequent nurse observation and centralized pulse oximeter monitoring. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, we may have underestimated participants\u2019 tremendous disease burden and overall physiologic challenges. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strictly speaking, however, OIH and opioid tolerance are conceptually different. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We confirmed intestinal mucosal barrier abnormalities in gluten-ingesting IBS-D patients, but HLA-DQ2/8 immunogenotype was not associated with alterations in SB or colonic permeability or mucosal inflammation, although genotype was associated with ZO-1 protein expression in rectosigmoid mucosa. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survey asked about whether each adolescent had ever been diagnosed with atopic dermatitis and absent school days due to atopic dermatitis, but it did not gather information regarding time of diagnosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Members of the genus Bifidobacterium spp. are proven to exert positive health benefits on their host due to their probiotic properties. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, breakfast skipping has been reported to associate with a higher risk of type 2 diabetes [45], whereas regular eating frequency may have a beneficial effect on body composition [46]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The evidence that a deacetylating complex plays a functional role in BIM down-regulation is supported by the fact that treatment with HDACi is able to restore BIM expression (Figures 4D and \u200band7C).7C). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our screening found 11 children with visual abnormalities, representing 8% of all children seen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In most C. trachomatis antigen\u2010positive or nucleic acid\u2010positive patients, titers of C. trachomatis antibodies detected by MIF were higher than titers for C. pneumoniae or C. psittaci. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as illustrated by our analysis of the FOXP2 locus, it cannot be assumed that overlapping but distinct variants have similar effect sizes or even directions; furthermore, such \u2018point-wise\u2019 analysis entails multiple statistical tests at each GSV locus, leading to potential inflation in the reported P-value for the region as a whole. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Historically at St. Jude, either an opioid only (fentanyl) or combinations of opioid and local anesthetic have been used. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For pO2 the CDI estimates were inaccurate, however with a level of precision comparable to the calibrated measurement series, corresponding to the introduction of a bias (Figure 1, bottom). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a population of patients with major depression of mild to moderate intensity this warrants that responders will have scores that are not relevantly different of what can be expected in a normal population and that are substantially lower than what is required for relapse or recurrence. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The \u201crule-of-thumb\u201d method however, assumes growth to be a linear function of size at different ages, which could subject the observed associations to statistical artefacts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lastly, the predictors of early childhood BMIz trajectories, especially modifiable ones (e.g., pre-pregnancy BMI and gestational weight gain), may help in developing effective preventive clinical and public health interventions for cardio-metabolic disease. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study examined how the neighborhood physical food environment was associated with cardiovascular risk factors in data from the third wave of follow-up of APCAPS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regimens to alleviate neuropathic cancer pain (Caraceni et al., 2004) and phantom limb pain (Bone, Critchley, & Buggy, 2002), incorporating gabapentin, opioids, TCA, and/or methadone, may be necessary to provide effective analgesia after LSS. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies also might focus on considering whether the changes in tolerance found in the present study buffered against stigma and, in turn, led to more positive health and social outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it could be clinically established that patients had significantly more well-being and less pain after ventral spondylodesis, possibly as a result of the less invasive treatment with only one operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been shown that approximately 60\u201384% of cancer patients who die of known tumours had developed bone metastases [9],but these figures are based on autopsy findings with gross examination and limited sampling. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results indicate that participants practising self-medication with analgesics for dental pain reported more positive beliefs in personal need for analgesics and did not view medicines in general as harmful and overused. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent study from Martinez et al. (25) identified significant correlation between ZO proteins, mast cell activation, and clinical symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decline in the frequency of performing BSE as people\u2019s health motivation increases suggests that they are not aware of the importance of BSE. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Secondary hyperparathyroidism may develop as a compensatory response to hypocalcaemia, and this will tend to cause increased bone resorption. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In views of rs3803300, both of the genotypes and alleles showed significant differences between the case and control groups and it was also an independent susceptibility factor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it is clear that there remains a need for an accepted foundation on which to base genome-wide searches for rare variants. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, TBXs, ACE, GATA4 genes polymorphisms are also the study targets in the onset of CHD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among a plethora of CIN definitions\u2014also including general definitions of acute renal impairment such as RIFLE, AKIN, and KDIGO\u2014this definition was chosen for several reasons. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In relation to physical activity, Australian regulations permit truck drivers to drive for up to 12 hours per day, which is often uninterrupted 18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This corresponds to fi ndings from a registry-based study of 42,233 THA patients with 6 years of follow-up. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also in 2015, an E. coli ST410 isolate harboring blaCTX-M-15 and blaCMY-2 and carrying blaOXA-181 on an ~48.5-kb plasmid and blaNDM-5 on an ~100-kb plasmid together with FIA and FIB replicons was reported in a study from Egypt (20). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ST410 belongs to phylogroup A, generally linked to commensal colonization (26), whereas ST131 E. coli belongs to phylogroup B2, dominated by strains associated with extraintestinal human infections, adherent-invasive E. coli (AIEC), and enteropathogenic E. coli (EPEC) (27). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recently, researchers have suggested that strong family and community ties may offer both \u201csupport and sabotage\u201d [13] through influential social norms, resources, and behavioral patterns. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data also suggest that cholesterol-targeted therapies may have a beneficial effect in diseases of nonglomerular origin that respond to CsA treatment, such as rheumatoid arthritis or psoriasis. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One reason for the different associations of eating competence with prediabetic states other than increased 2 h glucose may result from the fact that all participants in the present study were screened for a high risk of type 2 diabetes, which could have reduced variance in the measures of prediabetic states among the participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were several strengths and limitations of this study: 1. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only two cases, both presenting with influenza-like illness, were from the Welsh sentinel GP virological surveillance network. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither mutation alone has been shown to significantly influence asymptomatic asexual parasitemia by P. falciparum or P. vivax [13,20,24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results showed weak but significant correlations between the adjusted ROI analysis of mean FA-BSID relationships involving several white matter regions and the BSID subscales, which included cognitive, language, and motor scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For this reason material removal should be discussed with all patients who have dorsal instrumentation after bony regrowth either in the thoracic or in the lumbar sections of the spinal column. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The authors concluded that multimodal, standardized perioperative gastrectomy care according to ERAS principles appears feasible, safe, and cost-effective. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous research yielded similar inconclusive results acknowledging that the impact of perceived safety from crime and aesthetics on physical activity behaviors in residential neighborhoods needs careful examination [65]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Antifibrinolytic drugs prevent fibrinolysis and platelet activation from occurring during cardiopulmonary bypass: '6' tranexamic acid preserves platelet function and blocks the action of plasmin on fibrin,9 \u00a3-aminocaproic acid prevents activation of plasimiinogen,2 and aprotinin blocks both kallikrein ancl plasmin and preserves platelet function21 23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The examination includes gram staining of the amniotic fluid and measurement of leukoattractants, glucose concentration, white blood cell count, and interleukin 6 (IL-6) [11], [12]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Firstly, the clinical information and family of CHD patients and relative controls were investigated, the results showed that birth weight, premature birth, family history of CHD and mother's smoking had the significantly independent correlation to CHD, but not the other environmental factors in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the recommended daily serving of walnuts was higher and intervention period longer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A randomized controlled study is necessary in the future to overcome these limitations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results indicate the need to consider appropriate counseling and intervention programs that could potentially be used to manage or prevent the undesirable outcomes associated with social anxiety symptoms for adolescents. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other pitfalls are the sample size, which was too small to appraise heterogeneity within the HLA group, such as homozygotes, heterozygotes, complex heterozygotes, or DQ8-positive only, and the use of staining intensity to appraise the morphological changes in ZO-1 protein expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Australian sample, limited access to emotion regulation strategies, and the tendency to observe experiences and sensations consciously, was associated with higher social anxiety [5]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With regard to behavioral differences in deglutition between rats and humans, rats typically procure a bolus using a licking and a biting motion while humans commonly use their hands or a utensil. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In regards to the SOT regression results (Model 2, Table 3), our findings differed from what we expected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As part of the limbic system, the fornix is an important region for memory function. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the prophylactic effect of adenosine antagonism in our study seems similar to the effect published in literature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, net reclassification improvement was substantially attenuated with the addition of GRS63 to a BMD-adjusted base model, and no or minimal improvements of fracture prediction were observed when IDI, measuring the difference in average predicted probabilities between individuals with and without fractures, was evaluated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are widening gap compared with high-income countries in hypertension awareness[16]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we have labeled these as withdrawal symptoms, due to the short duration of abstinence periods in our study we could not verify the classic transitory pattern of symptoms and thus cannot rule out that these symptoms represent the simple offset of the direct effects of cannabis(Hughes, 1991). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In light of our findings, we propose that inflammation and energetic tradeoffs between immune function and growth may play a key role in driving this developmental plasticity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Probably there is under-reporting of the pacemaker explosions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the previously validated self-administered instrument used in the study might decrease the potential for social desirability bias, which is more likely to be present when participants encounter face-to-face interviews 20. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our data do not confirm the findings from German population [13] and do not support hypothesis that MCP-1 \u22122518 A/G SNP is directly involved in the genetic susceptibility to SSc. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings are compatible with previous investigations in British adults3, US24, and Singaporean-Chinese populations4 which showed an HR of 1.46 (95% CI: 1.08 to 1.98), 2.22 (95% CI: 1.69 to 2.91), and 1.54 (95% CI: 1.28 to 1.85) for long sleep duration, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After tracheal intubation and mechanical ventilation, a higher amount of ventilation in the ventral regions of the lungs was noticed, which would cause a mismatch between ventilation and perfusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, cervical specimens at 3 weeks were not analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Households may perceive childhood fever as more dangerous and urgent\u2014and so prioritize the timely care of children regardless of cost\u2014reducing the impact of poverty on delays for children of both poor and non-poor households. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the overall prevalence of obesity and abdominal obesity were 20.0% and 40.1%, respectively and 36.9%, 62.5% among hypertensive patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that increased inflammation in the blood and decreased immunomodulatory activity in the genital compartment are associated with atypically high levels of seminal plasma HIV-1 RNA levels relative to blood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the increase in subcutaneous fat fraction across BMI groups did not always correspond to a proportional change in the skeletal muscle fraction, a finding that has important implications for the validity of weight scalars using fat-free mass to estimate lean (muscle) body mass. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In partial support of the two-route account, recent investigations of semantic dementia and patients with unilateral anterior temporal lesions have, in fact, revealed functional asymmetries in the contributions of each anterior temporal lobe to verbal versus non-verbal processing domains (Lambon Ralph et al, 2010; Mion et al, 2010). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings also have therapeutic implications: After the defect in Nav1.4 was established in the patient, therapy with pyridostigmine (60\u2013120 mg three times daily), which increases the number of AChRs activated by each quantum, improved the patient's endurance; additional therapy with acetazolamide (250 mg twice daily), which is known to mitigate periodic paralysis due to Nav1.4 mutations, prevented further attacks of respiratory and bulbar weakness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An early onset transsexual development could be defined as one in which the person fulfilled the DSM-V criteria for gender dysphoria in children18. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This appears to reduce cost and increase consultations with appropriate practitioners [48]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The evidence base for increasing the uptake of active commuting is extensive [84], and active commuting presents an untapped opportunity to achieve regular physical activity. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pain is the predominant symptom of skeletal metastasis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The latter cases likely represent the shared environment with humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Secondly, the lack of evidences to verify the cause of full shape of adrenal gland. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Twin and family studies have shown a high heritability (50-85%) for BMD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two major new questions are raised by these data. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is estimated that approximately one in 5 American children have some form of vision problem 19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is well known that silencing of a gene through epigenetic mechanisms is a complex phenomenon [45,46]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggested that a major risk factor for hypertension among residents of Xinjiang is BMI \u2265 28.0, associated the highest addition to the risk score (23 points) of all of the risk factors examined, similar to several epidemiological research conducted in other countries [21\u201323]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A summary of significantly different parameters in the patient and AFM groups compared to the HC group is shown in Figure 7. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that ANP prevents early relapse in patients at least in part by preventing metastasis through the vascular endothelium. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BSE education must be provided to every women, since it is an important element in increasing the awareness for breast cancer and in understanding breast changes. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We demonstrated that prior cervical conization with posterior hysterectomy was safe and effective, with postoperative inflammation and infection controlled at low levels, when hysterectomy was performed 4\u20135 weeks or more after cervical conization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides hydration with bicarbonate and application of theophylline, a number of different prophylactic regimes have been investigated in the context of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, all the patients who had received preoperative antibiotic therapy were treated with the recommended standardized regimen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our cohort, mean IgG and IgM levels were significantly lower in AFM than in HC suggesting that AFM are genetically and/or environmentally predisposed to the development of PAD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-pharmacological interventions are also initiated before LSS and are continued long-term (Anghelescu, Oakes, & Popenhagen, 2006; Berde, Lebel, & Olsson, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential of this approach to reveal additional novel obesity-associated loci is supported by our analysis, which provides evidence to support reported GSV associations at 3 loci [10], [16]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other limitations include absence of information on some important variables, such as employment status (which was shown to be associated with QoL in previous studies), as well as income, current injection drug use, or other diseases except for HCV. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Particularly, we observed a strong imbalance and disequilibrium in production and activation of pro- and anti-inflammatory mediators. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, time to remission in patients with pulmonary involvement was increased, overall time to relapse was reduced and rate of relapse was greater in the methotrexate group, with notable adverse drug effects in each group24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During the IVR period, a greater amount of reduction predicted less problems and less dependence and a greater probability of a later quit attempt. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study found evidence that TB appears to have a negative impact on body condition of individuals, providing further evidence that the decrease in survival following the development of a cutaneous lesion is likely to be significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our group of patients, use of the ERAS protocol combined with laparoscopy resulted in 90% of the patients being mobilized early, and in 60% of the patients an oral diet introduced on the day of surgery was tolerated well. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This relationship between echogenicity and tissue pathology can occur in the face of normal IMT. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a recent study Kostopoulo et al. performed a genetic association analysis using a cohort of 1,410 Greek osteoarthritis patients and healthy controls and found significant association between single nucleotide polymorphism (SNP) 1784G>C in SREBP-2 gene and osteoarthritis development [24]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is therefore unlikely that the differences reported in serum hormone concentrations are due to metabolic effects of early cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clusterin can bind reversibly to A\u03b2 [Ghiso et al  1993; Zlokovic et al  1996], and has been implicated in A\u03b2 clearance across the blood-brain barrier [Bell et al  2007; DeMattos et al  2004]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, there was a significant trend toward cost reduction in patients with ERAS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hosaka et al. have shown that synovial lining cells, vascular smooth muscle cells, endothelial cells and macrophages in synovial tissue were immunopositive for angiogenin, raising the possibility that cells from the monocyte/macrophage lineage may modulate angiogenin expression [20]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients at increased risk of CIN receiving prophylactic theophylline, we found that additional hydration with sodium bicarbonate reduces contrast-induced renal impairment compared to hydration with saline. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is not surprising since gestational age likely impacts both white matter development in healthy full-term newborns (as demonstrated in our previous study [13]) and their neurodevelopmental outcomes (as reflected by the trend of correlations between gestational age at birth and BSID scores at age 2 years found in our study). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the ERAS protocol is currently part of our routine perioperative care independently of the type of surgery and operated organ, and it is possible that the results of similar studies in other centers with worse protocol performance could be different. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of complications in gastric surgery can vary significantly. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study contributes to the limited body of literature from low- and middle-income countries on the effects of neighborhood availability and accessibility of healthy and unhealthy food vendors on cardiovascular risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the limited research on ACE and MTHFR genes and osteoarthritis, present study provides an important contribution to the literature. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the German autopsy study, viral RNA titers were also detected in other organs such as the liver, kidney, or heart 24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our experience, the concurrent use of IV opioids and epidural opioids does not increase the risk of respiratory or central nervous system complications (Anghelescu, Ross, Oakes, & Burgoyne, 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They remain in use and ask (a) Has a pacemaker or any radioactive material been inserted in the deceased (yes or no)?", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daytime napping is a well-accepted routine among elder Chinese, as it may relieve stress and depression27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For these reasons, including historical open cases would be biased. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, pacemakers can migrate in the subcutaneous tissue, making detection by palpation difficult. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multimodal therapies that include two or more medications with different but complementary mechanisms, as well as nonpharmacological methods, are often used to achieve effective analgesia while reducing the required dose of each medication (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the SSFP imaging technique that has gained wide acceptance at 1.5T is prone to imaging artifacts at 3.0T because of the increased magnetic field inhomogeneity and radiofrequency (RF) distortion at higher field strengths. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive effects of bicarbonate hydration have also been reported in the prevention of postoperative renal failure in major vascular and cardiothoracic surgery 28,29. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They have no consistent modality selectivity but display distinct domain specificities and serve as hubs of neurocognitive networks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the limited data regarding pain intensity, we are unable to comment on associations of pain severity with the types of surgical procedure or with the specific pain management interventions applied. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that the current 6-OHDA model of Parkinson disease does indeed manifest oral processing deficits in rats. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When the effects of the subscale scores of the participants on the performance of BSE were examined, no correlation was observed on sensitivity, severity/importance and on perception of obstacles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results from the present study confirmed previously reported associations that the availability of a mix of destinations around homes\u2014shops and stores, and recreation facilities such as parks, walking trails, bike paths, and recreational centers\u2014was associated with a higher likelihood of active commuting or multi-modal commuting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eysel and Peters [3] report an average correction loss of 2.5\u00b0 after dorsal instrumentation and 2.8\u00b0 after ventral instrumentation, and we found similar radiological results for our patients in both groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Access to public transport in the neighborhood can act as a facilitator for a more active lifestyle among its residents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of atopic dermatitis was higher in the communities with higher GDP and larger city size. [40]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using a mixed-longitudinal design, we have shown that Shuar children experiencing relatively greater immune activity were shorter than their peers and grew considerably less over periods ranging from 1 wk to 20 mo. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of postoperative infection following hysterectomy conducted 4\u20136 weeks after conization was 2.67%, similar to the findings of other reports, whereas the rate following hysterectomy conducted within 2 weeks after conization showed a dramatic increase to 43.2%, higher than the rate previously reported (6.1%) [16]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although Models 2 and 3 reached similar shared variance (\u223c55%), more LOS variables predicted DHI, showing that this test is more broadly related to subjective symptoms than SOT, which showed only one predictive variable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This also emphasizes the additional benefit of RTX therapy in AAV, providing an opportunity to restore B cell homeostasis amidst an arsenal of autoantibody production against self-antigens and immune cell activation. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also believe the randomized design used in the present study increased one\u2019s confidence in attributing these increases in tolerance to the Oxford House model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However there is also evidence that low income and minority youth are at greater risk of under-diagnosis and under-treatment of vision problems 26,27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, all rats were exposed to hypothermia anesthesia at PND 4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The science of measuring and improving the built environment related to physical activity is inherently multidisciplinary. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although public awareness of breast cancer has risen, many people still are not aware of the importance of BSE in the protection from breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The goal of daily recruitment of one patient from the adult medical wards and one from the paediatric medical wards was aimed at ensuring a systematic sample through the year, but more consideration could have been given to ensuring a random selection among those febrile patients admitted during a 24-hour period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These factors lead to underestimation of the burden and circulation of enterovirus and biased information towards cases from retrospective outbreak investigations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas similar studies did not find significant differences in the MMPI-2 profile according to sex4,5,10, other authors have tended to indicate that MtF individuals are more psychologically distressed than FtMs3,25,26,37,38. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, E2 may increase 11-\u03b2-hydroxysteroid dehydrogenase type 1, leading to conversion of cortisone to cortisol, which in turn inhibits ACTH through negative feedback (20). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The measures used in our trial captured an array of abilities impacted by TBI and critical for societal reintegration and quality of life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, Choi et al. [8] did not demonstrate a statistically significant association between menarcheal age and global DNA methylation using LINE1 methylation as a surrogate for global methylation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, infant\u2019s gestational age at birth was the only factor that showed strong confounding effects in the correlation analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The accuracy and precision of the CDI have been tested by the manufacturer with excellent results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study can be considered as a standing point for future research on QoL in HIV patients in Georgia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Educating informal private sector providers in the immediate management of AFIs\u2014particularly in malaria-endemic parts of the Division\u2014might improve such practices, and save lives [10, 22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most of these are primary tied to the limitation in the studies we reviewed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings imply that there is scope to improve the accessibility and quality of the government sector, so that its well-structured but under-utilized hierarchy becomes a desirable option for patients with AFI. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All other patient subgroups have intervention effects that are at least in the direction of benefit. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These 5 arch forms had been concluded from 12 original arch forms, which had been identified from Ricketts\u2019s different studies 11. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, Greenough and colleagues observed increased dendritic material in layer V of parietal cortex following Hebb-Williams maze training (Greenough et al, 1979) and Kolb and colleagues noted increased dendritic length and branching in forelimb cortex after learning of a motor task (Kolb, Cioe,& Cameau 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pulmonary function changes seen in burned pediatric patients may be caused by a combination of airway and lung inflammation, scar formation, and decreased compliance from chest wall and loss of muscle strength. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to the association of this gene with HBV-related LC and HCC in our own studies, it has been reported that genetic polymorphisms of this gene, especially the rs7574865, are also associated with numerous autoimmune diseases [citation], indicating a crucial role in the immune system. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among them, MTAP, CDKN2A and ARNT/SETDB1 were also identified by eQTL and chromatin interaction mapping approaches in FUMA, and MC1R, TERT and OCA2 were also prioritized by the eQTL mapping approach to be potential causal or functional genes for melanoma development with FUMA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first study to examine both availability and accessibility of fruit and vegetable vendors and highly processed and take-away food vendors in the local neighborhood in relation to multiple cardiovascular risk factors in India. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, streptomycin was routinely administered for several months to patients with MAC lung disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the subsequent maintenance phase of 52 weeks will provide valuable information about the drug\u2019s efficacy in longterm recurrence prevention since a substantial rate of recurrences can be expected in untreated patients during the first year after recovery from an acute episode (Lavori et al, 1994). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is some controversy in the field. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possible differences in surgical procedures also might have influenced the postoperative pain intensity scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surprisingly, both LMC and STR males, in our split litter design, compared to AMC males, displayed increased cortical thickness, selectively, in infragranular cortical layers V and VI (see Fig. 4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the CMRA used in this study was designed to provide optimal visualization of the coronary arteries, and may therefore be suboptimal for demonstration of the cardiac veins. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strengths of the present study include its prospective nature and the fact that it is based on some of the largest available datasets with BMD and well-characterized fractures in both male and female older subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The post cryo-anesthesia life experiences of the rats used by Nunez et al is not as clear. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The S246L mutation alone was clinically silent and therefore either represents a rare polymorphism with detectable biophysical changes, but no clinical or EMG phenotype, or a recessive mutation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following the operative treatment the results of the SF-36 scoring system showed a dramatic improvement. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only a few patients had subsequent coronary angiography, especially among those exhibiting mainly attenuation artifacts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in the study among HIV-infected Brazilians by Razera et al, participants receiving ARV treatment had poorer general QoL as compared to those not receiving the treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Confounding factors may not only reduce the observed effects but also shift regions showing effects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the immunophenotypic parameters of CVID, IPH and IgGSD patients appear to form a continuous spectrum, we observed small differences in the type of infections they developed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limitations and conclusion There are several shortcomings to the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated PWVcf and wall echodensity identify vascular stiffening as an early and important contributor to cardiovascular decline; abnormalities in ABI and distal ICA mean flow velocity underscore the presence of arterial occlusive disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike the straw board, which was produced a very low temperatures, the cardboard is produced at temperatures that would make survival of C. burnetii sporelike forms impossible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Histological observation showed that inflammation (e.g., inflammatory cell infiltration) was most severe within approximately 1\u20132 weeks after conization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This decrease is likely explained by the short heart-to-detector distance, leading to positioning of the LV in an area where count sensitivity is slightly lower than in a more remote area, a property that was confirmed by further phantom experiments (results not shown). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as the self-confidence perception increased, the BSE practice percentage increased. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study confirms that five of these SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ) also affect individual susceptibility to HBV-related LC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low oxygen concentration (~5%) had a favorable effect on embryo quality by reducing the ROS levels produced in high oxygen cultures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exploring how differences in the association vary by buffer type and distance to food vendors may be important to improving our understanding of the mechanisms by which food environment influences cardiovascular risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies have demonstrated that minority population often consume unbalanced diet (e.g., excessive consumption of beef, sodium, alcohol, and mutton), which increases the risk of hypertension [29,32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is evidence to also suggest that childhood visual problems are a health disparity issue. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This phenomenon occurs primarily because the protective lymphocyte-dependent immune responses are reduced by marked decreases in lymphocytes [21], [22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dumoulin et al. [9] compared the effect of oxygen on human cleavage stage embryos development and found no differences in morphometric parameters. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Arrangements for routine enterovirus diagnostic typing are also highly variable [5,6]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, the self-assessment questionnaires showed, on average, an increase in spinal column function, an improvement in the general state of health, an increased sense of well-being, a reduction of back pain and increased mobility both for ventro-dorsal spondylodesis and for ventral spondylodesis over an extended period of time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the study includes a comprehensive questionnaire on different lifestyle and health factors, extensive clinical measurements including OGTT and careful adjustments for a multitude of potential risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nearly two-thirds reporte eating unhealthy foods on two or more days per week and consuming at least one can of sugary drink per day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Insufficient evidence of lack of intervention effect and continued measurement challenges We may have been unable to accurately measure the effects of the intervention due to insufficient data against the null hypothesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the employee's serologic testing for Q fever was negative. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nogueira-Silva et al. [21] reported a postoperative infection rate of 5.72% in 262 laparoscopic hysterectomy cases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect size (Cohens\u2019 d) also supports this notion, as the effect size for all outcomes was small to negligible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lassen et. al. have demonstrated that an early oral diet after major upper gastrointestinal surgery is safe and well tolerated by patients, and reduces the number of complications and even mortality [25]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early recognition and aggressive therapy is thought to improve the prognosis (Dworkin et al., 2003; Halbert, Crotty, & Cameron, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our analyses also showed that the arginine and proline metabolism pathway may be coupled with the insulin receptor signaling pathway to classify primary prostate tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cross-sectional studies, however, can only inform whether prayer is related to health, but is not able to identify causality in this relationship. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tajik ethnicity is mainly distributed in Tajikistan, Uzbekistan and China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the context of reports of compartmentalization of HIV-1 in semen,5,24 our results suggest that local factors contribute to seminal plasma HIV-1 RNA levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A multifactorial basis in the majority of CVID, and in extension PAD, would explain the vast variations in the clinical and immunological landscape seen in these patients 2,14.  ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The possible clone PC40-3, including PO10-3, -4, and -5, consisted of 28 isolates with 0 to 41 SNP differences, and most of the isolates carried blaCTX-M-15, blaCMY-2, and blaOXA-181. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this type of experiment (where a picture prime is followed by a matching, related or unrelated probe), the probe normally evokes a neural response that peaks in \u223c400 ms (N400) and that is larger if it represents a related or unrelated mismatch. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to consider the impact of RTX on more than just B cell numbers. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As observed on the LV projection profiles in Figure 1, this reduction in inferior attenuation was moreover associated with easier delineation and separation of the inferior LV wall from the attenuating subphrenic organs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no significant difference in the means of Bolton\u2019s tooth size ratios for males and females. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adenosine mediated vasoconstriction results in decreased renal plasma flow23. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This interpretation is in keeping with the generally successful performance of the patients on non-verbal tasks of object knowledge such as the Pyramids and Palm Trees and our Category Matching Test and their successful everyday use of objects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, there are only very few studies investigating the effect of statins on gut bacteria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Arterial hyperoxia has also been shown to induce vasoconstriction and reduce cardiac output, which may impair blood flow to the at risk organs[Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the LOS seemed to be a better predictor of subjective symptoms in our cohort than the SOT. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study two accelerated schedules were assessed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our study has limitations in its interpretations and findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No doubt the practice of self-medication provides benefits but it is also associated with potential risks including drug-drug interactions and misdiagnosis that can lead to severe complications [30,31]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Semantic memory itself may not represent a unitary function that can be localized but, instead, the collective and interactive contributions of more fundamental networks, each of which contains modality-selective synaptic hierarchies and domain-specific transmodal hubs that mediate the integration and binding of distributed information (Damasio, 1989; Mesulam, 1998, 2008; Martin, 2007; Cappa, 2008). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, the TSP approach can be used to identify patients whose prostate cancer will progress after they undergo radical prostatectomy. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such cross-network interactions are likely to have a distributed organization without necessarily relying on a single amodal area of domain-independent confluence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there were no differences in frequencies of the MCP-1 \u22122518 G allele and also of GG homozygote between German and Slovak healthy populations and further, these were similar to those reported in other Caucasian populations [13, 18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a study of Latinos and Latinas in Oxford House (Alvarez et al, 2004), residents reported feeling \u201c\u2026 a little nervous at first, but in 1\u20132 weeks I blended right into the house. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients must be fully informed of the potential risks and benefits associated with an aggressive approach; specifically, they must be made aware that data from appropriately conducted studies to demonstrate prolonged survival as a result of treatment is lacking. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reduced virulence coupled to phylogroup A could explain why ST410 has not been as globally dominant as ST131, even though ST410 is a slightly older lineage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prayer activity offers the CP patient the opportunity to re-interpret his/her pain condition within his/her religious meaning framework, re-establishing a sense of meaningfulness and purpose in his/her life despite the pain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using knemometry, we provide direct evidence for this hypothesis and the irregular nature of individual short-term growth (30, 65). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Before the study period, we were practically not performing gastric cancer surgery at all. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reductions in the number of glia and glia-associated markers have been demonstrated in visual cortex and frontolimbic cortex in neonatal stress protocols similar to ours in duration (Musholt, Cirillo, Cavaliere, Rosaria Bianco, Bock, Helmeke, Braun, & Papa, 2009;). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, our data indicate that ST410 has the ability to persist within a host for long intervals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maintenance of bone density may be one of the most compelling reasons for remaining on a gluten-free diet, especially in patients who have few symptoms on normal diet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings were to be expected as the SNPs included in the GRS63 were identified based on their association with BMD. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, the current study showed that contextual skills, a subcomponent of eating competence, were most strongly associated with metabolic risk factors for type 2 diabetes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "[15,16] El Hachem et al[15] showed that in gynecological surgeries, the pain intensity at POD 0 to POD 2 were not significantly different between a robotic and laparoscopic surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our cohort, B cell depletion and improvement in granulomatous inflammation is unequivocally related to RTX, as methylprednisolone was not administered, concurrent immunosuppressive agents were not altered and we achieved a statistically significant reduction in prednisolone dosage following sustained B cell depletion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Upon considering the strengths and limitations, future research with relevant modifications such as targeting a larger population in different clinical settings is certainly needed to further confirm the results reported.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the long latent period prior to diagnosis can result in misclassification of controls who may later develop dementia [Elias et al  2000; Snowdon et al  1997; Sperling et al  2011], and lead to survivor bias where individuals who would have been classified as cases have died from other causes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Survival rates following the primary session where cutaneous lesions were present were lower compared to uninfected individuals, suggesting that TB reduces survival in the advanced stages of infection, but the result must be interpreted with caution, due to low numbers of infected animals reducing the power of the analysis to detect survival differences. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Boys and girls with highly educated parents were more likely to have atopic dermatitis with increased severity than were boys and girls with less educated parents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has been shown that balanced perioperative fluid therapy may play a crucial role in postoperative recovery. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, Shebab et al. have not found a significant association between ACE gene I/D polymorphism genotypes in osteoarthritis patients and controls in Kuwaiti Arabs [8]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, cohorts selected on the basis of pronounced phenotypes may be difficult to recruit, a potential problem not only for variant discovery but also for replication, especially where the discovery cohort includes individuals not normally recruited to other cohorts (e.g. those with DD). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In prostate cancer, NO is involved in inhibiting androgen receptor activity and is associated with disease progression 27, 28. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increasing awareness and better diagnostic and virus characterisation techniques have improved ascertainment of EV-D68 over the past decade. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survival analysis supported the finding that TB risk increases with age, with only individuals that have survived for a relatively long time reaching the advanced stage of TB where lesions are visible. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interactions between immune-related tradeoffs and other factors influencing growth, such as environmental enteric dysfunction (66) and physical activity levels (67), also warrant further study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To explore the association of MCP-1 \u22122518 A/G SNP with susceptibility for SSc, our case-control study used the same methodological strategy as the original report [13], but importantly the size of the case group in our study was 2.5 fold bigger than the original one (46 versus 18). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with other techniques for imaging the cardiac venous system, CMRA is noninvasive and does not require injection of iodinated contrast medium or expose patients to ionizing radiation. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the patients included in this study must have received the most effective medication in terms of medical treatment, as compared with those in previous studies (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In line with earlier theoretical models, we hypothesized that prayer will be associated with pain tolerance, but not necessary with pain severity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It does not decrease the number of anastomosis dehiscence or intra-abdominal abscesses, and its use also increased LOS [32,33]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the KYRBWS-VI data in 2010 in Korea, the prevalence of alcohol consumption of 7th to the 12th grades was 23.5% in boys and 18.3% in girls [30]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even though both apoptotic signals were activated, it was not possible to understand if the two different pathways were trigged independently or not. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The more severe V1442E mutation may be dominant, but this cannot be proven because this mutation was observed only in combination with the heteroallelic S246L mutation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SF angiogenin levels were highest in patients with chronic synovitis characterized by prominent angiogenesis, such as RA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study we examined in vitro effects of CRS Type 5 plasma on RTCs and specific cytokine profile of these patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our survey of patients with acute febrile illnesses identified important delays, obstacles, and costs associated with multidimensional poverty, arising between onset of symptoms and arrival at hospital. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The vast majority of associative anomias occurred in conjunction with failures to define the word or the object. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since then, researchers had emphasized the importance of determining the prevalence of the different arch forms among populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also found that postoperative hospital stay did not significantly differ between the 2 groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A significant research gap remains to identify reasons for this heterogeneity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could have led to over-estimation of malnutrition and misclassification of some non-poor households as poor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We do not believe the lack of a treatment effect of progesterone was related to study procedural shortcomings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recognizing the fitness benefits of large adult body size (21, 69) and the close relationship between female skeletal and reproductive maturation (70) in our species, we suggest that immune-related energetic constraints on growth may also contribute to global variation in human life history patterns (reviewed in ref. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We showed that treatment with iodoform after conization decreased postoperative infection, indicating that if hysterectomy must be performed within 1\u20132 weeks after conization, additional iodoform instead of laparoscopic treatment is recommended. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some studies suggest that higher fear of crime was associated with lower levels of walking, and higher perceived danger for pedestrians and cyclists was associated with increases in car use [66], although some studies found no associations between changes in perceptions of safety and walking [67]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparing the results of studies which use similar methodology from a wide range of settings will be an important first step. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regulatory cytokines such as IL-6, a major inducer of acute-phase proteins, stimulate the synthesis and secretion of angiogenin protein and also increase the amount of angiogenin mRNA in human HepG2 cells within 24 h [32]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it remains to be elucidated whether MCP-1 \u22122518 A/G SNP may be in linkage disequilibrium with a causative variant conferring susceptibility to SSc, which may be located within the polymorphic CC chemokine genetic cluster on the chromosome 17.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our preliminary findings demonstrate that patient navigation (including a minimum of one faceto-face navigation session) to promote engagement in smoking cessation treatment merits further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The trial was designed with special attention to a consensus statement issued by the Austrian Society for Neurology and Psychiatry (Kasper et al, 1997). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A strong host immune response that results from an increase in the local production of proinflammatory cytokines and chemokines such as IL-1\u03b2, IL-6, IL-10, tumor necrosis factor-\u03b1 (TNF-\u03b1), granulocyte colony-stimulating factor (G-CSF), prostaglandins, and leukotrienes eventually allows neutrophilia to occur [19]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The model in Australian adolescents explained that 45% of the variance in social anxiety was accounted for age, sex, subscales of emotion dysregulation and dispositional mindfulness. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional precautions are necessary to rule out patients with poor renal function. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These early results of primary THRs with the Alloclassic-SL cementless femoral component are as good as the best results of both the early cementing techniques and when the latest developments in cemented femoral fixation have been used. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If hysterectomy must be carried out within 1\u20132 weeks following conization, abdominal hysterectomy including the suturing of uterine arteries and cold knife cutting procedures instead of electrical coagulation is recommended, and treatment with iodoform gauze after conization, an economic, convenient, and effective procedure, is also suggested, whether or not hysterectomy is to be performed. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we examined the association of fifteen SNPs derived from seven GWASs on susceptibility of HBV- or HCV-related HCC with the risk of HBV-related LC in the Chinese population, and found that rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ, were significantly associated with the risk of HBV-related LC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even in COVID-19 patients with overt DIC, bleeding manifestations have not been reported. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive predictive value has been reported to range from 30% in children in the 6- to 11-month age group to 76% in children 4 to 5 years of age.18 However, while mild amblyopia may be correctable with spectacle treatment alone, refractive adaptation is less likely to occur in children with deeper amblyopia and thus, must be identified at a younger age 38. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using higher parallel imaging factor, the acquisition time is shortened to 7.1 \u00b1 2.2 min in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Comparison of those results with the findings of the present study provide some indication that antifibrinolytic drugs may be of limited value in further reducing blood requirement in elective cardiac surgery. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ALT and AST increases did not follow a cumulative pattern but showed a tendency towards less severe elevations over time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, isolates found in the carbapenemase clade B4/H24RxC were all of human origin. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the locus by locus analysis, methylation of a single CpG site was shown to be associated with age at menarche. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At St. Jude, we use an algorithm for NP in which anticonvulsants, TCA, and methadone are added sequentially if the response to the maximum dose of the previous drug is inadequate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that the 5\u2032UTR of BIM promoter may have an important role in controlling the expression of the gene. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regarding the treatment of NTM lung disease, the American Thoracic Society has recommended that the initial therapy for patients with MAC lung disease consist of a minimum three-drug regimen of clarithromycin (or azithromycin), rifampin (or rifabutin), and ethambutol (citation). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the paucity of data in Asian populations on growth trajectories and their relation to later health outcomes, our findings fill an important gap and provide new insights into the role of early BMI development and its potential contribution to future metabolic disease risk in Asian populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to recognize that land-use mix is not just a research instrument for examining the impact of environments on physical activity, but is a valid planning tool that practitioners and policy makers can use to make neighborhoods more conducive to active lifestyles [60]. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is evidence for direct infection of endothelial cells not only in the lungs, but also in the kidneys or the small intestine with consecutive infiltration of mononuclear leukocytes and both endothelial and inflammatory cell death 36. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A dosage of 3 \u00d7 300 mg/day given for 6 weeks has been confirmed to be effective in acute treatment of depression with WS\u00ae 5570 and a comparable Hypericum extract (Laakmann, Sch\u00fcle, Baghai and Kieser, 1998; Kalb, Trautmann-Sponsel and Kieser, 2001; Lecrubier et al, 2002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As we relied on self-reports of stress level, there may be some limitation in the assessment of each student's stress level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, wind speeds were recorded routinely by the harbor authority but were very low during the week of August 5 through August 9, 2002, which makes windborne spread from the nearest farmland, 1 1/2 to 3 miles away, unlikely. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Men who do undergo treatment should be assessed and treated in a multidisciplinary setting including medical oncology, radiation oncology, and urology. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, our observation is consistent with the findings in the LIBCSP study, where breast cancer was associated with increased genome wide methylation as measured with LUMA [15]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We speculate that the administration of oxandrolone may have increased the strength of respiratory accessory muscles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The only association unambiguously replicated by our study was that between a 220 kb deletion of chromosome 16p11.2 and obesity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it seems possible that TNF signals primarily through p38 in macrophages or that macrophages and podocytes express different p38 isoforms leading to converse effects on ABCA1 transcription (55). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the 1990s Kehlet brought up a concept of multimodal perioperative care in patients operated on due to colorectal cancer that we now know as the ERAS protocol [22]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the most significant changes is the increased attention to documentation and treatment of pain in children from 1981 to 2007. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health professionals should screen for and incorporate co-existing psychopathological concerns into the treatment plan.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas these positive correlations might suggest to some that the GOSE alone is sufficient as an outcome measure in Phase III clinical trials, we agree with the recommendations of The Traumatic Brain Injury Clinical Trials Network Outcomes Subcommittee that a single, global measure is unable to fully evaluate the multiple components of outcome from TBI, nor can it capture all the important aspects of recovery 7. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 5 arch forms (normal, ovoid, tapered, narrow ovoid, and narrow tapered) can describe the dental arch measurements by more than just using 3 arch forms (ovoid, tapered, and square). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we did not systematically measure the success of blinding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, pacemakers are left in the body. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the normal resting potential of -90 mV, 98% of wild-type channels remain available, whereas for V1442E channels the availability is only 13% (Fig. 5A). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data should be considered with caution when treating orthodontic patients in the city of Jeddah.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in our series, we demonstrate that a standardized reduced dose of RTX (1\u200ag boluses administered on 2 occasions, 2 weeks apart) at less frequent intervals, remains effective in maintaining B cell depletion with some patients not requiring any further B cell depletion therapy over an 18-month follow-up period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, 4-day feeding of doxycycline chow in DT (podocyte-specific constitutively active Nfatc1nuc) mice is characterized by altered cholesterol homeostasis, podocyte foot process effacement, and albuminuria that can be partially prevented by cholesterol depletion (Figure 8). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the patients with M. abscessus lung disease also received standardized antibiotic therapy, which included 4 weeks of initial intravenous antibiotics while hospitalized. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endothelial cells that become inflamed during surgery are considered to be prone to adhering to circulating tumor cells, thereby allowing the initiation of metastasis (5, 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general, duration of advanced disease appeared to be very short, with the majority of individuals only caught once with an external TB lesion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The higher alcohol consumption in ECPs than in NECPs could be related to higher education level of ECPs [42]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TNF-\u03b1 is involved in the systemic inflammatory response in acute disease phases [9] and plays an important role in reproductive tract infections [10]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to its favourable safety profile (Woelk, Burkard and Gr\u00fcnwald, 1994; Ernst et al, 1998; Wheatley, 1998; Rychlik, Siedentop, Von den Driesch and Kasper, 2001), Hypericum extract can be an interesting, previously neglected option in this context. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, ECPs were physically more active and had better sleep quality than NECPs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar deficits in the LOS test have been reported in the elderly and in those with various neurological disorders;22\u201326 however, not in TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A role for FOXP2 in obesity is supported by the presence within the gene of independent SNP associations at P<10\u22123 with all of BMI [14], waist-hip ratio (adjusted for BMI) [15] and insulin resistance [27] (Figure S3). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies will measure the maximum expiratory and inspiratory pressures in our subject population, and will measure pulmonary function one year after burn injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This notion is supported by our finding that mice that specifically overexpress or lack expression of the receptor of ANP (i.e., GC-A) in the vascular endothelium have reduced or enhanced numbers of metastases, respectively, compared with the appropriate control mice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, according to Chang's study, the survey result from 442 participants in Korea showed that there was a significant correlation between education and income [47]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, Shaw et al. reported that atopic dermatitis prevalence was affected by high education level, living in metropolitan area, and high socioeconomic status [41]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar to the results of epidemiological studies (Blanco et al, 2015), we found that seeking treatment is uncommon. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Insulin receptor signaling also plays an important role in prostate tumorigenesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the oldest studies, the results were inconsistent. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inconsistencies may reflect interstudy differences in age, type of stressor, sampling paradigm, and dose, type, and pattern of glucocorticoid administration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Apparent tradeoffs become progressively less dramatic as immune function becomes more chronic, culminating in the comparatively modest impact of long-term, low-cost (5, 43) antiparasite humoral immune activity (i.e., IgE levels) on 20-mo growth and HAZ. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Volatile maintenance anesthesia without remifentanil is worth considering for minor operations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We prioritized 330 unique genes from 19 loci through positional, eQTL and chromatin interaction mappings, whereas only 38 melanoma-related genes were reported in the original meta-analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, our study findings can provide useful insights into the real-world efficacy, toxicity, and management of patients treated with trabectedin and can represent a good hypothesis to be investigated and validated through further prospective trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The tropism of SARS-CoV-2 for angiotensin converting enzyme 2 receptors expressed on endothelial cells seems to result in endothelial cell activation and apoptosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that combining patient navigation with another effective intervention could maximize its impact on promoting engagement in smoking cessation treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "OIH is a paradoxical pain sensitization of the nervous system5,8. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite numerous studies investigating the role of the miRNA associated DICER1 in CRC risk, the interaction between DICER1 functions and other elements, such as diet and environmental factors resulting in CRC, remain undetermined. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At present there are no data available in literature or specific trials evaluating the possible correlation between liver tests abnormalities of trabectedin and its efficacy in the treatment of STS, in terms of PFS and OS, which represents a strength of this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we would recommend addressing barriers to care for all ages, though the greatest gains of equity may be seen among adults. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indeed, consistent with our data, community education and intervention in a Norwegian early detection study of psychosis resulted in decreased average DUP (Johannessen et al, 2001;Larsen et al, 2001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To advance our study, we recommend machine learning approaches based on larger data sets with both training and test data. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More intervention and prospective studies are warranted to confirm these suggestions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wells (1946) recorded an overall prevalence of infection of 20\u00b75% based on post-mortem examination for macro-lesions, and also found that prevalence was highest in spring and early summer, and varied between sites. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with cancer, chemotherapy-induced renal failure may cause accumulation of the morphine metabolite morphine-6-glucuronide; therefore, hydromorphone or fentanyl may be preferable. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the educational level of parents could be used as a proxy variable of socioeconomic status in Korea. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the same time, convincing evidence exists that shorter programming may also positively affect lifestyle [15, 16]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In order to overcome these difficulties Meurer et al. [12] and Oga and co-workers [13] recommended additional dorsal fixation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whilst this study used peripheral blood B cell counts as an indicator of B cell repopulation, and this does not necessarily represent the proportion of B cells contained within pulmonary granulomata, it is becoming clearer that the balance of B cell subsets, particularly following RTX, is important in determining clinical outcome.20 Our group have characterized B cell subsets in AAV, by relative expression of CD24 and CD38. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intensified VTE prophylaxis (e.g. with an intermediate, half-therapeutic LMWH dosage once daily or with a high-risk prophylactic LMWH dosages twice daily) should be considered in patients with additional risk factors (e.g. body mass index\u2009>\u200930\u2009kg/m 2 , history of VTE, known thrombophilia, active cancer) and/or requiring ICU admission and/or with rapidly increasing D-dimer levels, taking into account renal function and bleeding risk. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the results should not be taken to indicate that the intervention should be withheld from some patient subgroups. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Achieving increased active commuting requires coordinated work among various stakeholders, but the benefits are numerous, and go beyond physical inactivity and sedentary lifestyles, including positive impacts on traffic congestion, air pollution, and carbon emissions [citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Snoring, a major marker of OSA, also affects about 40% of men and 20% of women without OSA, and is demonstrated to be closely associated with risk of stroke10,31. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast to the positive effect of bicarbonate on blood pH, hydration with sodium chloride has been associated with impaired renal function caused by hyperchloremic metabolic acidosis 32,33. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nine individuals did not complete the DHI, data on the total number of brain injuries were not recorded for eight, and medication information was not recorded for six. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results may indicate that, with regard to the body image concerns of MtF and FtM individuals, MtFs more often request visual changes to the body. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we do not identify the specific stimuli that increase local TNF expression in FSGS and DKD, it is interesting that exogenous TNF is sufficient to induce local TNF expression in podocytes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We analysed the in vitro cytotoxic effects of CRS Type 5 plasma on RTCs when it was added to culture medium for 24 hours. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, it is possible that the participants, by virtue of their membership in a patients\u2019 association, are more active than most individuals in the CP population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this analysis, the interindividual variability in volume of distribution was not explained by any standard or morphomic measure of body size or composition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, no survivor relapsed during the postoperative follow-up period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This would suggest reduction may be an acceptable goal On the other hand greater reduction did not predict increases in motivation to quit or decreases in perceived difficulty in quitting. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although most circulating tumor cells undergo rapid cell death by apoptosis (27, 28), it is possible that surgical inflammation promotes the adherence of residual cancer cells to inflamed endothelial cells (5, 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Enduring insecurities in basic needs result in emotional and stress responses in endocrine, immune, and nervous systems. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the only patients who did not require postoperative blood transfuision were those in the aprotinin group, differences between the groups were not statistically significant (Table VI). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous studies also used a similar design and sampling method. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the Vitrolife G-Series\u2122 media with its built-in VitROShield help protect embryos during culture and handling in the laboratory. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, laparoscopy allows for many benefits, such as lower blood loss, reduced postoperative pain, decreased number of complications, faster recovery, and shortened LOS [12,18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both, inflammation and coagulation, are synchronous responses of the host's defense aimed at containing invading pathogens. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The radiological evaluation showed that a stable fusion can be achieved through either type of operation over several years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were several limitations to this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We identified three main contributors to vascular stiffening. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, both LMC and STR pups might experience an early \u201cenrichment\u201d effect; daily \u201chandling\u201d of the pups may induce altered maternal behavior toward all pups which is regarded as an early enrichment effect (Kaffman & Meaney 2007; Ladd et al 2005, Meerlo et al 1999, Suchecki Rosenfeld & Levine 1993, Zaharia et al 1996) which may in turn increases cortical size in all pups (STR and LMC) in the split litter. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The blood samples were collected a mean of 7.8 years before diagnosis, and restriction of the analyses to cases who donated blood 2 or more years before diagnosis produced results similar to those cited. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is little doubt that this occurs: only 41% of forms presented to a crematorium were completed sufficiently for the staff to proceed without further enquiry12. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other studies, such as Bishara et al32 and Strujic et al,33 found that within different ethnic groups, samples showed a significant gender difference in Bolton\u2019s ratio, especially in anterior ratio. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this way, maximum signal transmission would be achieved across the entire sole of the foot. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patient's fatigable weakness involving lid-elevator, external ocular, and facial as well as limb and trunkal muscles and the decremental response of the CMAP on repetitive stimulation were consistent with a myasthenic phenotype. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some, but not all, deficits were shown to be significantly associated with self-reported balance problems listed in the DHI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As illustrated in Patient 14, TEE may be useful as a guide for invasive diagnostic procedures. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GSV Detection In general, large GSVs are more readily detected from genotyping or CGH array data, but occur infrequently so that phenotype associations are difficult to demonstrate statistically. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both genomic sequencings of bacterial rRNA from mice and humans indicate that a high-fat diet promotes a reduction of Bacteroidetes, while a fat-restricted diet results in the opposite scenario [21,22,23]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These liver enzyme elevations did not have a significant impact on PFS (HR\u2009=\u20091.124; p\u2009=\u20090.734) and OS (HR\u2009=\u20090.104; p\u2009=\u20090.850) of the total study population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our referral rate was also somewhat high at 8% compared to values of 4%8 and 5.2_x0018_ in other community based screening programs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As observed in previous studies, the implementation of single ERAS elements influences the perioperative period, but only full compliance results in improved outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Generalizability Not all eligible patients (43%) were included in the trial, which may have reduced the external validity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, we purposely selected the LARS methods combined with model selection by Mallow's Cp statistic over simpler methods of regression modeling, as LARS is known to be more resistant to biased estimates from partial correlations between predictors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The long-acting opioids used at St. Jude include oral preparations of morphine or oxycodone and transdermal fentanyl. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the future, a prospectively designed study involving a larger sample size in multiple centers, with an appropriate follow-up period, is warranted to verify these results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At least two independent reviews have provided evidence for a negative influence of longer DUP on short-term outcomes of schizophrenia (Marshall et al, 2005;Perkins, 2006;Harrigan et al, 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several land-use and transportation factors are known to be associated with active commuting [9,56,58,59]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, we evaluated plasma concentration of NGAL and many cytokines and we speculated about activation of cell signals pathway and the regulation of gene expression: our preliminary results can be considered as hypothesis-generating and stimulate further exploration of novel pathophysiological mechanisms in CRS Type 5.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data on the socioeconomic status of the respondents may not be accurate because students rather than parents provided this information. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The difference in schedule A was that at the first visit the administered dose was exactly half that of schedule B, as two injections were applied: 0\u00b75 ml of vial 1 and 30 min later 0\u00b72 ml of vial 2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the our study, we have recorded thigh pain in 4.6% (6 hips), and a subsidence rate of more than 2 mm in 16.3% (21 hips) at the end of the first year. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bone densitometry is a sensitive test for reduced bone mass but will not determine the underlying bone pathology. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This abnormality provides a potential mechanism underlying object naming and word comprehension failures caused by left temporal tip atrophy and also explains the preponderance of semantic paraphasias, superordinate identification errors and coordinate mispointing tendencies that have been reported repeatedly in patients with anterotemporal atrophy and clinical features of semantic dementia (Snowden et al, 1989; Hodges et al, 1992; Jefferies and Lambon Ralph, 2006). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present investigation extends these outcomes by showing that E2 potentiates both continuous and pulsatile intravenous cortisol-feedback effects on specific ACTH outflow mechanisms, viz., pulsatile, basal, and entropic modes of ACTH secretion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Skeletal muscle area at the L4 level is depicted in blue with red (inner) and yellow (outer) fascial boundaries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the exact functional relationship of this is unclear, the ability to search visual information is a prerequisite for learning involved in language and cognition, and the optic radiation is one of the first white matter tracts to be myelinated during infancy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although it is possible that BIM demethylation could require a longer time than the one allowed by the use of ALK inhibitors, these findings do not support the hypothesis that the maintenance of BIM epigenetic silencing is linked to the NPM/ALK kinase activity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternatively, transplant centers must be willing to pursue more donors for each search and thus potentially enrich the number available to choose the best donor for transplantation, beyond allele level HLA matching. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, as podocytes exposed to DKD and FSGS sera show increased local TNF expression, and TNF inhibition prevents patient sera\u2013mediated podocyte apoptosis (Figures 2 And 3) irrespectively of serum TNF levels, our data support the importance of locally expressed TNF as a major driver of podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only when the optimal operation window of opportunity between prior conization and posterior hysterectomy is appropriately chosen can the risk of surgery-related infections and complications be reduced. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mutations in the coding region of voltage-gated sodium channels are known to be a cause of epilepsy and cardiac arrhythmia, in addition to skeletal muscle disorders with myotonia, periodic paralysis, and now congenital myasthenia features (28). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While NP has traditionally been considered less responsive to opioid therapy (Caraceni et al., 2004; Gilron, Watson, Cahill, & Moulin, 2006), controlled clinical trials and clinical experience suggest that a subpopulation of patients with NP may benefit from treatment with opioid analgesics (Benedetti et al., 1998; Eisenberg, McNicol, & Carr, 2005; Rowbotham et al., 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laparoscopic hysterectomy is one of the most common surgeries for female patients [17,18]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the scores obtained from panograms (Fig. 1), this longitudinal LV motion did not exceed 5 mm on average for both upright sitting and biker positions, whereas it ranged between 5 and 10 mm for the supine position. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some experimental evidence exists that both of those pathways may also be associated with prostate cancer 29, 30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar findings were reported in studies among adults and Australian high school students which revealed emotion dysregulation and dispositional mindfulness were found to be associated with social anxiety [27\u201329]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There may be ethnic differences in the ability of the ACE polymorphism to influence susceptibility to OA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A post-hoc sample size calculation showed that to detect a statistically signifi cant between-group difference in HOOSPhysical Function of 3.3 points, using the standard deviations from our trial, 183 patients would be required in each treatment group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This hypothesis needs to be tested in future clinical trials. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future intervention testing should incorporate more detailed explanations of PA during the baseline data collection in order to more accurately measure intervention effects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also revealed that once is not enough, even in first grade. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several more studies had been carried out on the lower arch rather than on the upper arch to find out the prevalence of arch forms, especially in different malocclusion groups19-26 because, usually, in normal-occlusion cases, the upper arch form will follow the lower arch form, and the lower arch is considered the reference for which arch wires to be used in each patient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend that the use of such therapy be reserved for patients at high risk of postoperative bleeding, such as those undergoing redo operations or those recently weaned from fibrinolytic therapy 28,29.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relationships between the mean score of CHBMS subscales and the marital status, age, level of education, income level, knowledge of breast cancer and treatment options, family history of breast cancer and BSE attitudes of the participants were examined (Table 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A study conducted in England demonstrated that, although people with cancer who are of a high socioeconomic status are more likely to be diagnosed earlier, there was almost no difference between different socioeconomic levels in patients receiving medical treatment (Lyratzopoulos et al, 2012a; Lyratzopoulos et al, 2012b). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was stronger evidence for an association between cardiovascular risk factors and food vendor density within 400\u202fm buffer than density within 1600\u202fm buffer or the distance to the nearest food vendor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, even after these increases, the density was still low compared with normal age and sex matched adult controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the study findings provide information about QoL and some influencing factors among PLWHIV in Georgia, the limitations of the current study can be considered and minimized in future studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Finally, identifying and measuring all the resources, especially ARR, used in screening for secondary hypertension is still significant. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The only subject with <80% accuracy in both non-verbal object association tasks, Patient S11, also displayed the most bilateral temporal atrophy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our data, the association between testosterone and breast cancer risk exists more than 2 years before diagnosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For a better service to the public, all health care professionals should be trained about the breast cancer symptoms, risk factors and early-diagnostic methods, and about the screening centers and how patients can receive screening services. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This phenomenon was accompanied by a significant down-modulation of BIM expression (Figure 6G) that cannot be explained by the NPM/ALK-mediated phosphorylation of FOXO3a, because in BCR/ABL-positive cells, such as LAMA-84, FOXO3a is similarly inactivated by serine/threonine phosphorylation and cytoplasmic translocation [52] through a PI3K-dependent mechanism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For example, in patients undergoing major abdominal surgery, Guignard et al have demonstrated that intraoperative administration of relatively large remifentanil doses (0.3\u200a\u03bcg/kg/min of mean) increased postoperative pain and morphine consumption in the first postoperative day13. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because we used strict selection criteria in this analysis, and excluded anyone with confounding factors, we believe that our results can be likely attributed to the TBI event itself and can be generalized to those with mild to moderate classifications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only BIN1 (rs744373) and CR1 (rs3818361) out of the 8 non-APOE genetic polymorphisms examined were associated with rate of change over more than 10 years in global cognition and verbal fluency, respectively, in a study of 4,931 participants in the 3-C Dijon study (median age 74.0 years), and none were associated with decline in processing speed, visual memory, or premorbid mental abilities [Vivot et al  2015]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, similar inverse association was not found in studies from low- and middle-income countries (Dake et al, 2016; Jaime et al, 2011; Velasquez-Melendez et al, 2013), in accordance with our results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanisms remain unknown in humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results are in line with other larger trials comprising patients undergoing laparoscopic total gastrectomy [21]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, hormonal therapy is often accompanied by a change in gender role, better self-confidence, greater comfort with others, and better social skills43,44. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that the percentage of ACE gene polymorphic and MTHFR mutant alleles and the distribution of genotypes are significantly different between patients and controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Currently, the available NMDP/Be the Match tools of HapLogic (which uses patient ethnicity and HLA type to predict and thus select donor HLA haplotypes) along with center concerns about delay in identifying the HLA preferred (8/8 or 10/10 HLA allele matched) URD for transplantation may have induced pressure to limit the number of donors selected for additional or confirmatory typing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For instance, we were unable to attempt replication of GSVs that were originally identified in cases with severe obesity plus DD since very few of these were detected in our cohorts; some of these may reflect novel \u2018syndromic\u2019 forms of obesity whose replication will require analysis of additional \u2018obesity plus\u2019 cohorts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, hyperoxia facilitates a complex proinflammatory response and has been associated with cell injury by reactive oxygen species[Citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Plain radiographs are not particularly sensitive in identifying early metastatic lesions [13]and fail to detect about 20\u201325% of skeletal spread [4]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, compared to the CVID group, IPH and IgGSD patients had less severely decreased serum levels of all Ig isotypes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It might be considered as strength of our study that 63% of the patients were critically ill and treated in the ICU, since ICU patients are generally underrepresented in the investigation of CIN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lower prevalence reported in this study and the study conducted by Simon et al, may be explained by the fact that not all oral health problems were eventually brought to the dentist\u2019s attention as patients might experience pain relief after self-medicating with analgesics obtained from pharmacies [10\u201312]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provided essential information on the association between stroke and risk factors especially concerning the sleep habits of the population in southern China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results showed that both caspases were activated in RTCs incubated with CRS Type 5 plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decision to seek medical care poses a considerable risk of financial ruin, particularly for those already afflicted by multidimensional poverty [32, 45]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The raised OR in persons rarely near an open window or door compared with those often near an open window or door and the lack of cases among those who worked in the separate design office, or among sales representatives, suggest that the source of the outbreak was inside the factory. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was possible because, in recent years at our institution, surgery has been actively considered in patients with localized NTM lung disease when medical treatment appeared ineffective, before the lesions had become inoperable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We used high-dose aprotinin therapy, because the efficacy of low-dose aprotinin is still controversial 24. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biological mechanism of these polymorphims; ACE is a metalloenzyme converts angiotensin I to a potent vasoconstrictor angiotensin II [26,27]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Had Johnson used the term \u2018semantics\u2019 instead of \u2018lexicography\u2019 his statement would have summarized the main message of the present investigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Five of these six patients were also those with the most severe anomia and the greatest failure rates in defining the noun denoting the object they could not name. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CIN is associated with prolonged hospital stay and mortality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combined findings thus suggest that these four distinct BMI trajectories are real, rather than an artefact of the data-driven nature of the LCGMM technique. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the socioemotional and adaptive behavior measures, there were no significant correlations with mean FA values in any white matter ROI, after controlling for the confounding effects of gestational age at birth. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genetic studies of patients with OA can help to understand the molecular mechanisms responsible for specific disease manifestations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of serum-specific IgG antibodies can be predictive of the efficacy of the extract. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future progress depends on forging effective collaborations across disciplines, improving training and education, increasing the resources provided by funding agencies, and capacity-building efforts that cross traditional disciplinary boundaries to facilitate knowledge exchange between developed countries and LMICs. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future HGPS studies will benefit from rigorous longitudinal assessment of these parameters in both static and dynamic states. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The probability of recurrence of an infection in the spondylodesis segment should theoretically be higher in ventral instrumentation than in dorsal instrumentation due to the more direct contact with the former focus of infection [9], but Eysel et al. [4], and own experiences revealed a practically identical reinfection rate in patients with ventro-dorsal and ventral spondylodesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, these results suggest that pilot interventions designed to strengthen emotion regulation and mindfulness among school adolescents may be used to explore its effectiveness in preventing and managing the symptoms of social anxiety. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the study participants, the best QoL was observed in the dimensions related to social relationship and spirituality, and the worst QoL was observed in level of independence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second, we have used a unique translational approach combining clinical and experimental research to dissect the causal role of glomerular TNF expression in podocyte injury in DKD and FSGS, which are discordant in the level of circulating TNF. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous resting pulmonary function studies have shown degrees of impaired gas exchange and residual pulmonary pathology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the exact mechanisms by which cholesterol-lowering substances may interact with the human gut microbiome have not been sufficiently investigated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The definitions of hormonal therapy and onset age should be discussed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Failure to randomize among each day\u2019s admissions may have led to under-sampling of participants who were admitted for a short period, with rapid discharge or clinical deterioration and death. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the future, oligometastatic prostate cancer is likely to be defined based on genomic and biological features in addition to pertinent clinical criteria. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help clinicians or health systems prioritize patients for whom the intervention is most effective. \u200b", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since many of these factors can be approached by interventions, secondary prevention of schizophrenia focused on identification and intervention early in the course of the illness appears feasible (H\u00e4fner, 2002). ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CLU rs11136000 risk allele was also associated with faster decline in memory as measured by the California Verbal Learning Test of word list delayed recall in 95 cognitively normal participants in the Baltimore Longitudinal Study of Aging who converted to MCI or AD (mean age 75.9 years at first assessment [Thambisetty et al  2013]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Workplace health promotion enables truck drivers to overcome many of the limitations of their workplaces, which underpin their poor healthy eating and physical activity behaviors and may be a key strategy in improving the poor healthy eating and physical activity behaviors and outcomes such as obesity. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The recommendation for prolonged VTE prophylaxis, at the initially prescribed dosage, should be communicated to general practitioners in discharge documents and reviewed by a hematologist or vascular specialist. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prioritized 330 genes showed enrichment in peptidylserine phosphorylation of STAT protein, immunity, TLR signaling and G1-to-S phase cell cycle progression-related pathways. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Parents or care providers who treat adolescents with atopic dermatitis should consider not only whether a child was stressed but also the degree of stress. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These differences in the position and configuration of the larynx may reduce the probability of aspiration in rats [19, 52, 72]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the current study, both the mastication rate and bolus speed were significantly slower for the old rats. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In other cases, the atrophy is more bilateral and gives rise to the combined impairments of language and object recognition that fulfil the Neary et al (1998) criteria for semantic dementia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These deaths bore no relation to the choice of therapeutic method. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore the difference between the 2 groups regarding stronger endpoints like need for dialysis was not statistically significant but showed only a trend favoring hydration with bicarbonate. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The loss of normal antithrombotic and anti-inflammatory functions of endothelial cells leads to dysregulation of coagulation, platelet activation, and leukocyte recruitment in the microvasculature, with complement activation likely playing an important role in the context of COVID-19-associated pneumonitis and purpuric skin lesions 28 29 30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Animal experiments32 among rabbits demonstrated that the resistance to airflow in the upper airways and subsequent production of energy from the vibrations of the pharyngeal wall may be transmitted to the proximal carotid artery wall and lumen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the small numbers of inflammatory cells in patients with IBS-D, the absolute numbers of cells are relatively small; therefore, the study had adequate power to detect such a difference, if it was present. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Common side effects after opioid administration are nausea, vomiting, constipation, dizziness, physical dependence, sedation, and respiratory depression[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "R0 resection rate was 89%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the response rate to the survey was 97.7% (73,238 of a possible total of 74,980), representing a majority of Korean adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Liver metastasis is one of the most important prognostic factors for CRC, and increasing evidence indicates that synchronous metastatic colorectal liver disease is associated with a disseminated disease state and a worse prognosis 5, 20. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The discrepancy in smoking prevalence between boys and girls may be explained by the social norms influenced by Korean Confusion culture that smoking women are not culturally well-accepted in Korea. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several studies have reported that lutein/zeaxanthin action induces cell-mediated and humoral immune responses12,40. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dust containing C. burnetii sporelike forms could have been sucked through the balcony doors from the renovated offices, fallen onto the workforce below, and inhaled by those infected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The latest version of the MMPI-2, the MMPI-2-restructured form, could not be used because the beginning of this study preceded the availability of this version57. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Optimal pain management after LSS at St. Jude addresses not only acute postoperative nociceptive pain, but also persistent long-term nociceptive pain related to prolonged physical rehabilitation, and NP related to surgery or chemotherapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with language impairments, inaccurate verbal definitions of objects may therefore over-emphasize the loss of object knowledge. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a nurse-managed intervention in the VA setting, Jackson, et al reported that the intervention effect was confined to African American patients[citation]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrahigh serum aldosterone also has been detected in renal artery stenosis and renin adenoma, and the numeric of PRA was not low also. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In colorectal surgery it was shown that compliance with the ERAS protocol influences outcomes [23].", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, we suggest that contextual skills were the main determinants behind observed associations between eating competence and metabolic health in our study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, even over the 3 months of the study, most users attempted both abstinence and reduction, suggesting goal is a state, not trait, phenomena. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In young children, vascular testing is limited by the child\u2019s ability to withstand testing and by a paucity of standards for comparison. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant variation in lesion prevalence was observed between the 3-study years of the longitudinal survey, with the highest prevalence occurring in 2001 (7\u00b701% in 2001; 5\u00b752% in 2002; 5\u00b743% in 2003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "first cleavage cleavage division; 2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, despite the evidence that NPM/ALK is not critical for the maintenance of BIM epigenetic silencing, these findings, albeit preliminary, suggest that NPM/ALK itself may be the initiator of the BIM epigenetic silencing pathway and that other NPM/ALK-independent mechanisms may be then recruited to maintain its repressed status. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among various nutrients related to DNA damage, Haegele et al. proposed an inverse association between plasma lutein and oxidative indices, showing that lutein affects DNA damage repair71. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data demonstrate clearly the immunogenic activity of the modified allergen preparation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is remarkable consensus by all national pediatric and vision related national organizations that early childhood screening to detect children at risk for amblyopia is important 1,2. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the psychological functioning did not differ according to age for the FtMs, our results were as expected for the MtFs in terms of hypochondriasis, which is more frequent with older age40,41, mainly because of greater concerns about health problems. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By implementing more actuators and FSRs, a more sensitive pressure distribution map of the foot could be developed and used to locally adjust the amplitude of each individual actuator. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the conflicting reports in the literature [8], [15], [18], we aimed to replicate, in a dataset with whole genome methylation data, the association between age at menarche and DNA methylation that we observed with the LUMA technology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patient's apneic attacks and the requirement for a conditioning train of stimuli at 10 Hz to elicit a decremental response at 2-Hz stimulation closely mimic features of a presynaptic CMS caused by mutations in CHAT (14, 24). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whilst no apparent effect on immunoglobulins is observed after a single dose of RTX, IgM levels reduce over time and repeated dosing is associated with depletion of IgG levels and impaired humoral immune responses35\u201338. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It must also be recognized that most attenuation artifacts could be easily identified through an expert visual analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sufficient SNR and image quality were maintained by imaging at 3.0T and utilization of 32-channel phased-array coils [20\u201322]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most common trabectedin-related AEs reported in the studies are nausea, vomiting, constipation, increases in alkaline phosphatase/AST/ALT, neutropenia, anemia, thrombocytopenia, and fatigue4,5,6,16. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We can hypothesize that the absence of these different psychological disorders as a result of hormonal therapy may accelerate an individual\u2019s potential eligibility in the sex reassignment procedure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This process is also described by Park (2005, 2006) who stated that religiousness is associated with appraised meaning of stressors and with subsequent adjustment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Extending such programs may help to reduce household expenditure and promote early consultation and escalation. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Introducing patients to the navigator in the clinic setting, at the time patients express interest in smoking cessation treatment, could increase intervention uptake. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that the selection of taking longer nighttime sleep duration among elder people was explained by fatigue or driven by disease burden and co-morbidities6, although we have included common chronic diseases in our analysis, other diseases were possibly responsible for the prolonged sleep duration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Insurance also increases capacity to respond to high costs of in-patient care when this is necessary [46, 47]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reactivity measurements performed on peripheral mononuclear blood cells from allergy patients have shown that allergoids, similar to native allergen extracts, possess substantial T cell stimulation capacity [16,28]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This outcome seems particularly likely in instances when individuals gather together for advocacy or self-help movements to overcome stigma, only to be hampered by interpersonal differences and other biases in regard to ethnic, religious, or socioeconomic characteristics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This work shows that contrast-enhanced whole-heart CMRA at 3.0T can depict the normal and variant cardiac venous anatomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, the requirement for at least three aminoglycoside serum drug samples for inclusion led to the exclusion of a large proportion of patients and likely enriched the sample in patients treated with definitive aminoglycoside therapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to confirm our results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, we explored the association of GWAS-identified HBV- and HCV-related susceptibility SNPs with the progression from CHB to LC in two independent cohorts of Chinese population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, we found that the frequency of GYPC\u0394ex3 and SLC4A1\u039427 differs in the two study populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Parkinson disease has negative effects on several of the of oral stage components of swallowing [40], although measurement of swallowing deficits with videofluorography in patients with Parkinson disease can be variable [66]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As opposed to B- and T-cell na\u00efve and memory subsets, mean expression levels of the here-examined co-stimulatory molecules and chemokine receptors on B and T cells were not significantly altered in AFM compared to HC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed that 15 of 146 primary aldosteronism patients had a raised ARR, who did not have Hypertension only accompanying Hypokalemia, or even without any clinical symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this process, separase (ESPL1) is released from securin (PTTG1) upon activation of the anaphase-promoting complex (APC), and the SCC1/RAD21 subunit of cohesin is cleaved by separase through a SMC5-SMC6-mediated mechanism [17]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite its striking popularity (for example, in Germany, Hypericum extract had a market share of 25% of all antidepressant prescriptions in 1997 and outsold fluoxetine by a factor of 4 (M\u00fcller, Kasper, 1997; Harrison, 1998) the prophylactic effect of the herbal drug has so far not been investigated systematically. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preemptive use of gabapentin (2000) In our institutional experience, the pain management service and surgical team meet with the patient and family pre-operatively to discuss options for postoperative analgesia and epidural analgesia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An explanation for this may be that the built environment variables are more relevant to walking and bicycling rather than motorized transport [69]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A previous study from the USA found a positive relationship between supermarket density and risk of hypertension (Tamura et al, 2018). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although most of our patients (n=17, 74%) had preoperative culture-positive sputum for NTM, negative sputum culture conversion was achieved within 1 or 2 months postoperatively and was maintained in all survivors, excluding the two patients who died postoperatively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that pulmonary resection can play an important role in achieving a better outcome in selected patients, especially patients in whom medical therapy failed or who had a remnant lesion with a high possibility of relapse. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In concordance with the apoptosis rate, we observed a fourfold increase of caspase-3 activation in RTCs, which was associated with a higher extent of apoptotic death. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These two signaling pathways seem to be independent: analysis of the relationship between the genes from those pathways using all possible types of interactions identified no cross talk between them (data not shown). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite these limitations, our results confirm that measurement of skeletal muscle is superior to surrogate descriptors that estimate this parameter with height, weight, and sex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, the CS was analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we were able to assess the surgical outcomes of 23 patients with NTM lung disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, the distribution of ACE gene I/D and MTHFR gene C677T genotypes were analyzed in osteoarthritis patients in a Turkish population to assess its possible role in the pathogenesis of osteoarthritis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data do not indicate a consistent effect of caffeinated coffee consumption on SHBG in men or women, however results should be interpreted with caution given the small sample size.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Under careful monitoring, chemotherapy dosage or schedule adjustments may not be necessary in similar patients positive for HBV or HCV.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2017;123:1989-1997.\u221a\u00c7\u00ac\u00a9 2017 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The question-behavior effect can be used to reinvigorate blood donation among lapsed donors, and can be as effective as forming implementation intentions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Music training program helps appreciation of music and may enhance their progress in other auditory domains after cochlear implantation in children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children did not accumulate adequate PA or consume calories or fat excessively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows the lack of normative consensus about ACP and highlights the need for consistent educational programs regarding the role of the CBLTC provider in the ACP process.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, midazolam can be used in low induction doses as an alternative to etomidate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anesthetic regimen of 0.75 MAC isoflurane for intraoperative cortical SSEP monitoring may be optimal.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical implications warrant systematic evaluation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutritional screening with validated tools in hospitalized patients remains poor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are necessary to understand what HIV protease mutations should be considered and whether such mutations should be weighted differently to improve LPV GIQ predictive value.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More studies are needed to determine the long-term effects of bariatric surgery in morbidly obese patients with NASH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One of the mechanisms by which TMD, particularly if supplemented with virgin olive oil, can exert health benefits is through changes in the transcriptomic response of genes related to cardiovascular risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There appears to be a substantial medical burden associated with bipolar disorder, highlighting the need for collaborative care among psychiatric and general medical providers to address both psychiatric and other medical needs concomitantly in this group of patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings indicate that if aggression plays a role in problematic driving, it is likely not limited to the road.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This investigation led to the recall of approximately 60 000 bottles of contaminated cough syrup, widespread screening of potentially exposed consumers and treatment of over 100 affected patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Testing this hypothesis may represent a direction of future research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduced PON1 activity and increased MDA could be considered a biochemical marker for lipid peroxidation, which require follow-up in patients with NAFLD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wider studies are needed to confirm our observations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ISDM as one of the conservative treatment modality for IC/BPS should be attempted more strictly because of its noninvasiveness, without alterations to the other treatments.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ClinicalTrials.gov Identifier NCT00795704.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results underscore the significance of the effect of URE on QoL, particularly with respect to uncorrected presbyopia, which has been a relatively neglected area in research and policy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adherence may be important for microbiologic cure of select pathogens.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support the importance of individual differences in personality on therapy outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The developed taxonomy (BCTTv1) provides a methodology for identifying content of complex BCIs and a foundation for international cross-disciplinary collaboration for developing more effective interventions to improve health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association between low socioeconomic status and diabetes management requires further research given the  paucity of evidence and the potential for diabetes management to mitigate the adverse effects of low socioeconomic status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is felt that the cheaper, smaller, easy to integrate, sterile and more user-friendly laser guidance unit may be a better alternative to the needle guide in improving procedure times for the novice ultrasonographer or to assist the expert, during training for, or performance of, ultrasound-guided targeted procedures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results add compelling support for the effectiveness of an interdisciplinary, school-based obesity prevention intervention to prevent disordered weight-control behaviors in early adolescent girls.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Directly targeting positive affect in relapse prevention during remission might be a way to enhance treatment effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In dry eyes, where sodium hyaluronate monotherapy was insufficient, diquafosol tetrasodium was effective in improving objective and subjective symptoms, suggesting its viability as an option for the additive treatment of such eyes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, EPA and DHA supplementation should be considered as additional therapy to an angiotensin-converting enzyme-inhibitor or angiotensin-receptor blocker in subjects with type 2 diabetes mellitus and coronary artery disease.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that IFG occurred in 30% of \u221a\u00e9\u00ac\u2264 TM children, perhaps due to insulin resistance secondary to iron overload.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Emphasis on the need for testing in HIV+ women is necessary.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides initial evidence that the Internet-based alcohol misuse prevention course has beneficial short-term effects on hazardous drinking behavior among first-year college students, which should be reinforced through effective environmental prevention strategies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of marital status and education level on sexual function  merits particular attention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although more studies are needed to find out the clinical relevance of aromatherapy for anxiety disorders, the present results indicate an acute anxiolytic activity of sweet orange aroma, giving some scientific support to its use as a tranquilizer by aromatherapists.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addition of plasma PlGF at 14-16\\xc2\\xa0weeks of gestation to clinical risk assessment improved the identification of nulliparous women at increased risk of developing preterm pre-eclampsia, but the performance is not sufficient to warrant introduction as a clinical screening test.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The nature of bone malformations directly influences the presence or absence of external syrinx and syringomyelia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The haplotypes of DC-SIGN may be susceptible to the risk of FK, whereas the analysis of Dectin-1 gene polymorphisms showed no significant association with FK risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The direct association between Mediterranean diet and peripheral artery disease that we have found should be evaluated through a follow-up study under clinical practice conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pedicled NSF seems to be helpful in avoiding the concentric growth of the granulomatous cyst epithelium while assuring ventilation and drainage of the cyst.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to a cognitive-behavioral program, after the intervention, adolescents who received mindfulness showed greater reductions in depressive symptoms and better insulin resistance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional strategies beyond removing economic barriers are important to augment adherence to road safety behaviours for injury prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effects of Aerobic Exercise Training on Arterial Function and Insulin Resistance  Syndrome in Obese Children: A Randomised Controlled Trial: NCT00801645.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings give support for the short-term efficacy of CMTR in the two Chinese populations and contribute to the literature that self-help Web-based programs can be used to provide mental health help for traumatized persons.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results need to be interpreted with caution as they are based on two separate studies, but do call into question the need to screen for diabetes distress in people with Type 2 diabetes in primary care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical weight loss resulted in the significant improvement of OSA  associated with obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the importance of considering subgroups of patients with LRTI to develop RP evidence-base practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of  higher intensity or combination LLT as recommended in secondary prevention are needed to increase the achievement of LDL-C treatment targets and reduce the risk of morbidity and mortality due to CHD.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of WBV and ES could be considered a promising alternative to reverse the musculoskeletal atrophy and improve peripheral vascular properties in SCI patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our observations suggest that tramadol seems to be a safe alternative to fentanyl for labor analgesia due to its similar analgesic efficacy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overweight at the first antenatal visit is a common risk factor for IGR, DM and MetS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, these asymptomatic screen-detected prostate carcinomas have genetic signatures comparable with those commonly seen in symptomatic cancers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rehabilitation providers and purchasers need to consider the place of care in the light of local needs, to provide the benefits of both kinds of services.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In gastrointestinal metastases, size (<35\\xa0mm) could be used to select patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventional studies with lifestyle modifications are warranted.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observations confirm the need of a rigorous monitoring of patients taking statins, in particular pre-diabetic patients or patients presenting with established risk factors for diabetes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The identification of valid and accessible biological markers of suicidal behaviors still represents a challenge for future research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although further prospective research is warranted, our results suggest that use of a multidisciplinary approach for DFUs may augment healing time and reduce amputation risk compared with previously published historical controls of  standard wound care among patients with advanced stage 4\\xa0disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It might be a first step in improving statin adherence in this extremely high risk group.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on these results, PET-CT is a valuable method for early diagnosis and treatment in difficult cases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adding an allowance for accumulation of thyroidal iodine stores would produce an EAR of 72 \u221a\u00e9\u00ac\u00bag and a recommended dietary allowance of 80 \u221a\u00e9\u00ac\u00bag.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pre-frail condition was inversely associated with overweight.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of a framed active choice to a message  significantly raised enrolment rates in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical use of PBS as a root-end filling material may be an alternative to MTA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIALS REGISTRATION: URL: http://www.clinicaltrials.gov.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL RELEVANCE: Healthcare professionals should screen for nocturia and poor  sleep and offer appropriate nonpharmacological lifestyle management, behavioral interventions, or pharmacotherapy for women with diabetes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study extends current knowledge regarding the pharmacokinetics of firocoxib and provides information that can be used to establish appropriate withdrawal time guidelines following multiple administrations, with respect to already established plasma regulatory threshold concentrations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study show that ADM used as membrane associated with ABM/P-15 can be used to reduce buccal-palatal dimensions compared to ADM alone for preservation of the alveolar ridge after extraction of anterior maxillary teeth.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the results of the current study did not indicate significant differences, healthcare professionals may still consider creative therapies as a viable option for patients within hospital or outpatient clinics because they do not require specialty training or costly resources, and they may be an enjoyable activity to occupy time for patients and caregivers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to develop criteria for more selective use of acellular dermal matrix in these patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fit elderly NSCLC patients should be considered for salvage targeted therapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ROC-ADO study demonstrates the need to empower the relations between school health providers and addiction consultations.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LV leads positioned in the apical region were associated with an unfavorable outcome, suggesting that this lead location should be avoided in cardiac resynchronization therapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results should be taken into account in the management of GERD patients in clinical practice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The differences found by NH size support the hypothesis that the number of residents living in a NH has an impact on how nutritional care is performed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This ratio can be used as a novel noninvasive marker to predict IR and advanced disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the outcomes in poorer acuities should still be viewed with caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Still, several myths regarding breast cancer persist.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(LEVANT I, The Lutonix Paclitaxel-Coated Balloon for the Prevention of Femoropopliteal Restenosis; NCT00930813)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results indicated that CM+GF prepared by tissue engineering technology can be considered an alternative method for the treatment of Miller Class I recession defects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study suggests that dyslipidaemia may be associated with a higher risk of developing lumbar disc herniation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is no apparent add-on effect of BF training in short-term follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide preliminary data for future work examining outdoor school environments, active transport to school, and childrens physical activity in India.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with diabetic nephropathy were found to have a > 40% chance of accelerated progression of their disease as a result of pregnancy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be considered as an accepted and cost-beneficial procedure for upper pole renal stones.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical approach and stent usage did not significantly influence symptom outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results obtained with the Pilates method were comparable to those achieved with the Back School method, suggesting its use as an alternative approach to the treatment of non specific low back pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This efficacy, good tolerability, and ease of administration make ciprofloxacin otic solution 0.2% without a topical steroid an attractive option for the treatment of acute otitis externa.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Performing chest compression with music can easily be integrated into CPR education because it does not require additional technology and is cheap.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Quality improvement strategies to increase metabolic monitoring over the rates seen here  and in other studies should be developed and implemented.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HC pharmacokinetics can differ up to 10-fold inter-individually and individual adjustment of treatment doses may be necessary.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Crohns disease, an inadequate dietary intake is correlated with nutritional status and disease activity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus Rhodiola algida has the potential to be used concurrently with chemotherapy to alleviate the occurrence of oral ulcers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first study in Mexico evaluating prediabetes and diabetes as breast cancer risk factors in women with no first-degree relatives with breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cite this article: Bone Joint J 2016;98-B:1180-4.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with EHPVO and obstructive jaundice, primary biliary tract surgery has significant morbidity and mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research should be directed at understanding the mechanisms behind the lack of effect of MMN supplementation on  morbidity measures and limited effect on growth.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non detection of CGA at second trimester ultrasonography is a predictor of preterm delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This information is important for the evaluation of knee alignment measurements in current clinical practice, to assess severity of deformity and to accompany pre-operative planning and post-operative evaluation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Legionella pneumonia should be included in the differential  diagnosis even in cases of mild to moderate pneumonia when presenting with extrapulmonary symptoms, especially in diabetic patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such educational programs should be adopted in clinical settings to enhance knowledge and self-care behaviors.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This gene could then be added to a set of genetic markers to identify individuals with an increased risk for developing T2DM and complications associated with dyslipidemia in diabetic patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The unroofing and marsupialization procedure provides more clinical benefits in the treatment of pilonidal disease than rhomboid excision and Limberg flap and should be considered the procedure of choice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It could be classified\\xa0as a BI-RADS category 4a lesion and tissue diagnosis is warranted.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most significant difference between the states is that of helmet use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the need for larger trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carbetocin is a reasonable effective alternative to syntometrine in prevention of PPH after cesarean delivery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that maternal eating and emotion responsiveness are important for understanding the interpersonal context of feeding behaviors, and child weight outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant, positive associations between breast cancer risk and PCBs and PFAAs were observed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We propose a nomogram to enable clinicians to better estimate mortality in patients with ascites undergoing umbilical hernia repair.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may have implications for DSM-5 diagnostic criteria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More prospective studies with larger sample sizes are warranted to validate our findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-oleic peanuts contributed to higher DIT, higher sensation of fullness and incomplete compensation for energy intake compared to conventional peanuts and may be useful to dietary intervention to reduce body weight.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority had multiple components.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The design and methods of LOVIT may be applicable to other trials of rehabilitation services and to outcomes for which reliable and valid measurement tools must be developed.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov: NCT01334359 and NCT01619826.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Retrograde intrarenal surgery is an option for treating medium sized renal stones in preschool children with results comparable to those of shock wave lithotripsy and a safe short-term outcome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, it  provides patients with more realistic assessment of potential outcome of the procedure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In selected cases, extending the time  of SO use did not worsen the prognosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIAL REGISTRATION NUMBER: UMIN000001677.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our experience with 3D-CRT APBI demonstrates excellent cosmesis and  local control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed that dexamethasone added to levobupivacaine in a TAP block applied for analgesia following a caesarean section procedure prolonged the time required for analgesia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We must find a strategy to provide adequate slow-wave sleep duration to reduce the obesity epidemic at young ages.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ophthalmic Surg Lasers Imaging Retina.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We addressed the terminological controversies regarding pathological fractures, and suggested the term spontaneous fractures denoting a fracture occurring during normal jaw function being either pathological or non-pathological.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Classic acupuncture and YNSA are similarly effective in the prophylaxis and treatment of migraine headache and may be considered as alternatives to pharmacotherapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased long-term variability of PPG is a strong independent risk factor for prolonged QTc interval in type 2 diabetes patients, in addition to long-term postprandial hyperglycaemia and current HbA1c.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a randomized controlled trial of 230 infants with genetic risk factors for celiac disease, we did not find evidence that weaning to a diet of extensively hydrolyzed formula compared with cows milk-based formula would decrease the risk for celiac disease later in life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMT may thus be a possible adjunct in the risk assessment of aneurysm rupture, and a helpful tool in patient risk stratification and counseling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient beliefs prior to a diagnostic screening can influence ASRS self-report ratings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher intake of polyunsaturated fatty acid might be inversely associated with PD risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genotyping these variants may help to achieve the benefits of statin therapy more safely and effectively.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients should be followed longer for late relapses and secondary tumours.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgery done as soon as possible is helpful to reduce the force caused by the obstruction and helpful to the normal facial growth.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this cohort, hypertension and haematuria were prevalent while renal disease was rare.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Formal nutritional assessment, however, is inadequate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our sample of the general population, resistin was inversely associated with measures and levels of PA and HDL cholesterol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence to suggest that body contouring plays an important role in the weight loss patients journey and that patients need access to treatments.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Older age, comorbidity, obesity and emergency room admission were strong predictors of IHPC in diabetic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Not applicable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breast Ca risk factors in CAR did not appear to be significantly different from that observed in other populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In diabetic patients with MV-CAD, CABG was associated with a lower rate of long-term MACCE relative\\xa0to PCI for both ACS and SIHD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with low socioeconomic status were more often obese, physically inactive, smoking, and had elevated blood pressure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Histopathologic analysis of temporal bone specimens provides evidence supporting  the exposed marrow theory of PA cholesterol granuloma formation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DBT increased lesion conspicuity but failed to accurately assess tumour size of ILC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The robotic treatment of kidney stones represents a comparative alternative to flexible ureteroscopy, with overall similar outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We currently do not recommend administration of Cogmed for early school-aged children born extremely preterm/extremely low birth weight to improve academic functioning.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our analysis suggests that CKD should not be a major driver in the decision-making on the duration of DAPT after stent implantation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Current chemoprevention guidelines may be falling short in their dissemination and implementation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Methylphenidate may lead to a reduction in concurrent methamphetamine use when provided as treatment for patients undergoing behavioral support for moderate to severe methamphetamine use disorder, but this requires confirmation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using linear trend analysis on the entire field sequence may not be optimal for detecting and monitoring progression.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trials evaluating specific micronutrients are required in order to investigate specific nutrient-infection interactions in CSOM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LMWH plus LDA was successfully used as an alternative to UFH plus LDA in the management of recurrent abortion secondary to APS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of patients with stenosis or both leakage and stenosis required rescue operation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evidence  suggests that these reductions were realised by decreasing stress and conflict, improving household well-being, and enhancing womens decision making, self-confidence and freedom of movement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnant women who  are obese, however, should be advised to exercise because it attenuates excessive gestational weight gain.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To safeguard the wellbeing of staff and patients, greater planning, coordination and ethical oversight should go into the closeout of trials involving withdrawal of treatment(s).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lack of statin-OxPL-apoB treatment interaction suggested that\\xa0OxPLs might be statin-independent therapeutic targets to reduce risk of cardiovascular events.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with SD-PEG, LV-PEG+Asc exhibited equivalent bowel-cleansing efficacy and resulted in improved patient acceptance and preference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may stimulate lymphocyte and neutrophil responses and may be a useful modality in treating muscle inflammation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were no significant differences between the apoB/apoA\u221a\u00e9\u201a\u00d1\u00a2 ratio and the non-HDL-C/HDL-C ratio for the prediction of carotid atherosclerosis among Chinese individuals with MetS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In elderly patients with severe but asymptomatic AS, mild symptoms may be difficult to detect, particularly when mobility is impaired and severe symptom onset is common, warranting close clinical follow-up.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary advice by  a dietitian and use of potentially helpful dietary supplements is indicated.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ligament's clinical and anatomic significance is unknown.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings will aid the development of interventions for improving the mental health of women with breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical procedures can be broken down into constituent, essential, and elemental tasks necessary for the safe and effective completion of a reference approach to a specified procedure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The remaining loci will require a comprehensive investigation to exclude or verify their significance in  Mexicans.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that, add-on memantine would be helpful, in the adjunctive treatment of depressive, positive, negative and general symptoms in patients with schizophrenia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger scale prospective studies are needed to determine the effects of PCOS on the mortality and morbidity, and to clarify the  relation between the duration of the disease and development of these alterations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The vaccine had a favorable safety profile and may help to reduce the risk of anal cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rhinosinusitis should be suspected in events of recurrent preseptal cellulitis even in the absence of nasal symptoms.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both observational and self-reported measures should be included in evaluating outcomes of rehabilitation for patients with fibromyalgia.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To show the effect of the other parameters, more research is needed with larger patient groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals at high cardiovascular risk who improved their diet toward a TMD pattern showed significant reductions in cellular lipid levels and LDL oxidation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals with FeMS were more likely to use CAM, particularly supplements.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Counselling patients with DM2 to start insulin with more than one injection per day in Day Hospital setting achieves and maintains a good metabolic control in the medium term in different patient profiles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Assessment of C3d fixing as part of prospective HLA monitoring can potentially aid stratification of patients at the highest risk of long-term renal allograft dysfunction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre-filled blister packaging may provide an inexpensive solution to improve medication adherence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Paracetamol 1g IV given preoperatively decreased anaesthetic requirements and the need for postoperative analgesics similar to the preoperative administration of ketorolac 30mg IV.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, each method had both benefits and costs, and the choice of method should be based on context-specific criteria.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Care providers should select their patients for early discharge and pursue a low threshold for readmission.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elderly survivors of stroke with Hchol who were admitted for rehabilitation showed higher admission and discharge FIM scores but similar functional FIM gains as compared to NHchol patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because RSL offers flexible scheduling and facilitated oncoplasty, RSL may replace WL for resection of nonpalpable single breast lesions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, the OS-MRS is not correlated with the appearance of early complications or mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recommendations from trained PINCER pharmacists were found to be broadly acceptable to GPs and led to ameliorative action in the majority of cases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the benefit varies according to the adiponectin basal level and adiponectin variation after supplementation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To overcome these barriers; training sessions should be organized within or in connection with work hours, support should be secured from team management and work shifts should be planned to enable attendance for all participants.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A positive result from this study would enhance the repertoire of treatment approaches available for the management of obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Appropriate regulations of UA, Hb and urine protein after diagnose may be a promising treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the study do not provide support for the use of divalproex ER in the treatment of youths with bipolar I disorder, mixed or manic state.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The non-attendance rate in the secondary paediatric referral centre studied was low.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results support the clinical utility of this new once-daily formulation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This treatment approach thus does not represent an alternative to early instillation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incorporation of an anxiolytic into pharmacotherapy regimens could improve BP, namely, to reduce and stabilize its circadian profile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prehospital nausea and vomiting are more common in our cohort of trauma patients than the reported rates in the literature for nontrauma patients transported to hospital by ambulance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decrease in varicocele prevalence as a function of body mass index regardless of varicocele grade suggests this explanation is less likely.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LDL-C should be measured by direct homogeneous assay in routine clinical laboratories, as the calculated methods did not have a uniform performance for LDL-C estimation at different TG levels.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study showed a favourable effect of locoregional treatment in patients with PMBC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Special attention should be paid to fluctuations in weight that may occur throughout the course of treatment with risperidone.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical results should be considered preliminary due to the small sample size.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, ECV shows early potential to be a useful biomarker in health and disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed the potential efficacy of robot-assisted fingers training for hand and fingers rehabilitation and its feasibility to facilitate early rehabilitation for a wider population of stroke survivors; and hence, can be used to complement CIMT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, underweight and wasting were  significantly high.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the literature, the most-frequent cause of hemolytic uremic syndrome in patients following renal transplantation is recurrence of the hemolytic uremic syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, the results of this study provide a rationale for performing a morphometric evaluation of VFs in all women undergoing treatment with AIs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DM and metabolic syndrome (MetS) have negative influence on fertility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Importantly, this research points to the need to target both sleep and obesity in order to break this vicious cycle.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the whole cohort did not show a significant change in arterial stiffness with ADT, some patients showed an increased arterial stiffness monitored with the CAVI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MRI should be regarded as the gold standard investigation for patients in whom a scaphoid fracture is suspected clinically.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum Cu/Zn ratios may reflect vascular complications of PE, and the ensuing increases in lipid peroxidation may play important pathogenic roles.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is feasible to combine tDCS targeting the LE motor cortex with our novel locomotor training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of repeat PR should be refined in larger trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rigorous testing, including randomized controlled trials of large-scale implementations, is needed to examine how these school-based interventions might be used to improve the physical activity and fitness of larger populations of children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The neurodegenerative process underlying dementia overshadows formerly significant predictors of cognitive change.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consumption of minimally processed food is inversely associated with  excess weight in adolescents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the beach chair method (at the plane of the transverse process) provides another promising option for lumbar plexus block for the non-obese population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, strategies to reduce albuminuria should be emphasized especially in these subjects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative indicators of psychopathology, notably indicators that are dimensional in nature, are important in predicting postoperative outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because medium and small LDL particles are more highly associated with cardiovascular disease than are larger LDL, the present results suggest that very high saturated fat intake may increase cardiovascular disease risk in phenotype B individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the use of current rapid-acting insulin analogues, patients who dose PostP are characterized by poorer glycemic control in all patients and a greater prevalence of history of severe hypoglycemia and diabetic  ketoacidosis in children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that the application of IPC can be considered as an effective method to prevent deep vein thrombosis for immobile patients with brain injury.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further development of a full Japanese version of the SCREEN II  is indicated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of this study can be used to effectively target future educational and encouragement initiatives.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide initial support for the use of guided self-reflection as an alternative to coping skills approaches to resilience training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further work is needed, it seems clear that a complex interplay of inflammation and the development of DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants can be enrolled successfully in a clinical trial for RRMS, but factors affecting the time to achieve the requirements needed to start screening can be unpredictable and problematic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PDT led to remarkable improvement and furthered necessary preconditions for long-term stabilization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observations may be of interest to elucidate the pathogenesis of peripapillary atrophy in glaucoma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The contrasting results between Caucasians and Chinese could be due to different LD patterns and allelic frequencies or genetic heterogeneity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Detecting compliance predictors could help in the planning of early interventions to improve CPAP adherence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With shifts in policy focus, the utility of POC devices for patient engagement in CVD preventive care may be demonstrated if fully integrated into the clinical setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research should attempt to replicate these findings in a larger-scale trial using a more sophisticated, user-friendly program and additional measures of improvement in more diverse samples.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This retrospective study, despite its limitations, underlines the clinical particularities of critical ischaemia in diabetics and the good tolerance to iloprost.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unnecessary use of analgesics should be prevented.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Perfusion and diffusion MR images provide different information compared with (18)F-FDOPA PET in LGGs during follow-up and therefore, they should be considered as complementary tools in the evaluation of these tumours.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results add strength to the evidence showing that PALB2 is involved in BC risk for both sexes and indicate that consideration should be given to clinical testing of PALB2 for BRCA1/2 mutation-negative families with multiple MBC and FBC cases.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, TT genotype may reduce the risk of CAD in diabetic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SCH treated by L-thyroxine leads to a significant improvement in CV risk factors and symptoms of tiredness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thirty percent of patients with heartburn and regurgtitation did not have abnormal acid reflux.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bimatoprost solution represents a therapeutic option for scalp AA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The result-interpretation feature of the IONA software should facilitate wider implementation, particularly in local laboratories, and should be a useful addition to the current screening methods for trisomies 21, 18 and 13.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DKA has a high incidence rate in children with type 1 diabetes, and  the development of DKA is associated with age, parents educational level, and family income.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Supervisor support influences health outcomes of workers, and it is possible to improve supervisor support by an intervention which involves the workplace and supervisor.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results have important implications for future dosing strategies and may limit the utility of dronabinol as a treatment for opioid withdrawal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The worst QOL domain related to environmental stimuli and the best QOL domain to limitations of the activities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The short-term application of ZOL may not be sufficient to improve the outcome in postmenopausal patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oral impacts were more frequently reported in T2D cases than controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study suggests that fractional CO(2) laser therapy followed by NB-UVB phototherapy could be used effectively and safely as an alternative modality for the treatment of refractory vitiligo.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effects largely persisted after taking into account mediation by middle-age hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data are consistent with the hypothesis that exposure to air pollution is adversely associated with measures of HDL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reproductive factors were to some extent associated with all subtypes; the strongest trends were with luminal-like subtypes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addition of ITS to systemic steroid and HBO treatment may yield better results in patients with SHL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Second-generation hydrogel coils can be used in a wide spectrum of aneurysms with a risk profile equivalent to bare platinum.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Involved field radiotherapy was tolerated reasonably well.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This analysis suggests that plasma PCSK9 combined with LDL-C concentrations might be useful to predict certain PCSK9 LOF mutations such as the R46L mutation but may fail to predict others such as the InsLEU mutation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The BCVA was also similar between groups; however, the MICS group had more central endothelial cell loss at the 1-year follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The multifactorial nature of ARI severity and vitamin A status highlights the need for a comprehensive approach to public health programmes to address ARI.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In subjects self-reporting PPHG after surgery, lower presurgery plasma glucose concentrations, higher insulin sensitivity, and better \u221a\u00e9\u00ac\u2264-cell glucose sensitivity are significant predictors of PPHG after both RYGB and LSG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION NUMBER: Australian Clinical Trials Registry (ACTRN12610000049077).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physical activity energy expenditure was high in this population and was inversely correlated with CVD risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, supplementation of 1 RDA before and 2 RDAs after surgery resulted in better improvements on iron metabolism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replacement of partially hydrogenated oils with unhydrogenated oils would likely produce substantial reductions in CHD incidence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-invasive CPAP should be considered as the first line of treatment because it is easier to use and less expensive than non-invasive PSV.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the results of this study obesity and severity of distal radius fractures do not correlate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger future studies should confirm this association and investigate methods to minimize recurrent falls through management of such medications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings suggest that, besides a reduction of costs, by participating in \"Telemedicine for the Heart\" patients with chronic heart failure experienced a reduced number of hospital stays, optimized medical therapy, better quality of life, and reduced mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Greater encouragement of these skills may help reduce reliance on UPF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GISTs may represent another example of the obesity paradox in which obesity\\xa0seemingly provides a protective effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our preliminary experience with the Penumbra mechanical thrombolysis system confirms previously reported results showing the efficacy and safety of the device in treating acute stroke caused by the occlusion of large intracranial vessels.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Critically ill patients with subarachnoid hemorrhage show a strong association between hyperchloremia and acute kidney injury as well as acute kidney injury and mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies must focus on systems for predicting the appearance and severity of postoperative complications classified  according to the Clavien-Dindo system, and not only on mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that FOXC1 is correlated with chemosensitivity to anthracycline and could be used as an indicator of chemosensitivity in sporadic TNBC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Knowledge of molecular factors is necessary.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be useful to aim future interventions at healthcare professionals rather than patients to improve the prevention of familial cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, comprehensive teacher training should be viewed as an integral component of future school-based interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "OCTA is a dyeless, quick, and noninvasive method which allows to detect ischemic changes in DR and might be a useful tool in observing the progress of the disease and the response to anti-VEGF treatment in clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regular exercise incorporating elastic RET should be used to attenuate muscle mass loss and prevent physical difficulty in obese older adults with sarcopenia on reconditioning therapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HRQOL among individuals who engage in self-care when treating the common cold was observed to be significantly higher than among individuals who preferred to attend a health clinic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IL-6 level can be a useful indicator of survival time of patients with advanced cancer at the very end of life.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both preparations demonstrated equal antiinflammatory effects for the treatment of AAU.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The consumption of fortified cereal elicited greater increases than for unfortified cereal and improved biomarkers of micronutrient status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Good understanding and avoidance of operation-related complications are important to guarantee the technical success of TLABS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Simple mouthwashes can be used to relieve or eliminate some uraemic symptoms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One year after treatment, both groups achieved similar clinical results; however, patients endodontically treated in a single visit suffered less postoperative pain and took less analgesics than patients treated in two visits, therefore a single-visit treatment should be recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings shown here, including the association between myopericytomas and arterial IT, the incorporation of the latter into the tumor and the similar phenotype of their respective myoid and myointimal cells, support a close relationship between these processes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only a quarter of children with stroke had recorded lipid testing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential advantages of using PLLA-screws compared to metal screws are not sufficient to warrant the routine use of PLLA-screws in ACL-reconstructions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Yet, these associations are warranted to be investigated in prospective studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results showed that nutritional assessment can be employed with  community-dwelling older adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Levothyroxine administration with breakfast could be an alternative regimen for patients who have adherence difficulties due to the need for delaying intake, and is more likely to cause variability in the TSH level, meaning the patient should be followed more closely.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It represents a reproducible and potentially beneficial approach within the context of the Brazilian public health system.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: University Hospital Medical Information Network (UMIN) ID000010663.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are important for planning dietary strategies to improve physical health in scientific workers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Soft tissue evaluation is important before dental rehabilitation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was significantly associated with DME in female patients with T2DM, but not in male patients with T2DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional information on the serotype of S. pneumoniae isolated is necessary to assess the potential impact of immunisation on preventing pneumococcal infection in Malaysia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LGP has the potential of being an ideal weight loss surgery for adolescents, resulting in excellent weight loss and minimal psychological disruption.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other, preferably nonpharmacologic intervention studies should be considered to improve symptom management of PBT patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the main, believing a method to be beneficial was strongly related to its use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because fatigue is known to persist among persons with SCI, interventions to reduce fatigue seem necessary.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CHA2DS2-VASc tool predicts thromboembolic events and overall mortality in patients without atrial fibrillation who have implantable devices.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When controlling for other factors, the authors report no differences in care based solely on payor type.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the high amounts of accelerometer-derived sedentary time in this age group, more efforts are needed to develop strategies to reduce children's sedentary time.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A narrow spacing of the tip-ring electrodes is recommended in the LAS, particularly in the presence of LVH on ECG.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This appeared mediated by reduced tolerance of adverse symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions targeting specific cognitive domains, such as attention or working memory, need to take into account the patients' overall cognitive and emotional self-perceived functioning.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This increased risk should be considered when choosing a vascular access device for chemotherapy, especially in patients with solid malignancy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite this, overall satisfaction and perception of success of the procedure reduced markedly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, GTN is associated with a higher rate of headache, and should be replaced by DTZ.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two techniques of posterior chamber IOL have both advantages and disadvantages, and can be used accordingly.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study contributes important information regarding the safety of balneotherapy in hypertensive and obese diabetics by showing no alterations of antioxidant, inflammatory, or metabolic indices.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, our findings showed a discrepancy between lifestyle-related practices and beliefs, and between each of these and evidence-based recommendations for maximal health, i.e., not smoking, several servings of fruit and vegetables and whole-grain foods daily, healthy weight, restorative sleep, and low-to-moderate stress levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results showed no effects of aromatherapy on QOL, sleep quality,  and vital sign.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Severity of asthma defined by medication category was not a predictor of sensitivity to SO2.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be a useful alternative treatment option for melasma when topical bleaching is ineffective or not tolerated.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results from the feasibility study will inform on the design and sample required for a large multicentre RCT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reductions in T-cell subsets cannot be used as predictive markers for the clinical response to therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In severe CH, it is important to choose an initial dose at the higher end of the recommended range to achieve these goals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as MHR was higher in the patients with good prognosis compared with the  patients with bad prognosis, we believe that regarding the ISHL, MHR is not a predictive value but might have prognostic marker.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No unexpected safety issues were identified with either treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HDL cholesterol may have a protective effect against sepsis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that an AHR-guided treatment strategy may need to be sustained in order to preserve lung function.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore it is a recommended procedure that should be used more widely.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgery for chronic pain generates great expectations especially because it is considered a hope of cure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Myocardial infarction occurs frequently in patients admitted to intensive care with GI hemorrhage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results demonstrate that lipophilic drugs can be developed for LTT; although the nude rat is suitable for testing drug permeability, delivery is systemic.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On this basis, distress screening through the illness trajectory into long term survivorship seems warranted.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The primary outcome for a definitive MOD trial should be health outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the present study provide evidence to support the use of the D-Flex system as a valid, portable, and easy to use alternative to the weight-bearing lunge test when assessing ankle dorsiflexion ROM in healthy participants.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It underscores the need of involving parents in youth alcohol prevention programs, and the need to target both parents and adolescents, so that change in parents' behavior enables change in their offspring.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Current Controlled Trials number, ISRCTN74348595.)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most children with increased head circumference as a symptom of intracranial expansion are identified during the first 10 months of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These associations should be replicated in other studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the potential use of a VR-based approach in memory training in people with MCI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The polymorphism of the MBL gene may be one of the genetic factors that determines susceptibility to SS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study will add important knowledge about the potential of antigen carbohydrate 125 as a management tool for monitoring and titration of therapies where optimal utilization has not been well defined, such as diuretics and statins.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, more needle aspirations could be required, and there could be more cases of wound dehiscence  in patients who do not undergo auxiliary drainage.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multiple epidemiologic, geographic, clinical, and immunologic factors are involved in the etiology of AP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EF is poorly recorded in primary care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Large prospective studies are required to determine if gemfibrozil can reduce CVD events in uraemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings emphasize the importance of considering service users' perceptions of therapy and can be used to guide clinicians in deciding whether to include one or more of the components of WELLFOCUS PPT in therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The disease specific formula should therefore be the preferred option to be used by diabetic and hyperglycemic patients in need of nutritional support.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, granulocytapheresis cycles could be prolonged or repeated, if necessary, in more severe diseases without significant risks for the patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-lasting implications of these abnormalities for visual function of the child need to be studied.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A combination of individual fatty acids, characterised by high concentrations of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower incidence of T2D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A larger proportion of patients reached cholesterol lipid goals with  simvastatin 40 mg/day.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, while CCBT may be an acceptable treatment, its suitability for secondary care settings remains unclear.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The throwing motions are similar between softball and baseball, but the athletes adapt to the demands of the sport differently; thus, stretching/strengthening programs designed for baseball may not be the most effective programs for softball athletes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High sodium concentrations in spot urine were associated with subsequent systolic blood pressure increases among non-overweight normotensive individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was apparent that the majority of users were satisfied with herbal remedies use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that HDL-3 levels were more predictive of CAAD status than HDL-2, HDL-C, or apolipoprotein A1.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study supports the use of intensive care unit bedside PDT in the obese population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A need exists for CBOs to include health promotion in their mission and vision statement and job descriptions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several metabolites, i.e. C18:1, citrulline, trans-4-hydroxyproline, three glycerophospholipids and SM (OH) C14:1, might be related to prostate cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medical and psychological preparation should be offered to candidates for these competitions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A carefully integrated diabetic retinopathy screening service is needed, particularly in remote areas, to improve adherence rates.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, there was good agreement between the manual and automated feedback systems, giving promise to the use of automated systems for personalizing dietary advice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Single-jaw procedure may lead to less stability, leading to skeletal relapse, than double-jaw procedure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of selective COX2 inhibitors was not significantly related to AF occurrence, except in patients with chronic kidney or pulmonary disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study showed that children of acute diarrhea with above risk factors need stricter monitoring for complications to reduce diarrheal mortality.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that simple, low-cost interventions can enhance enrolment in health promoting programmes and also be pragmatically tested within those programmes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Smoking cessation should remain a high global priority for clinical care and research in PLWH.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In obese women, but less so in men, measures of body fat distribution, of which VAT most strongly, are associated with cardiometabolic risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment of type 2 diabetic patients with tesamorelin for 12 weeks  did not alter insulin response or glycemic control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transaminase levels cannot be used as a surrogate marker of HCV infection in these patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chemotherapy followed by radiotherapy is preferred for limited SCLC, while surgical resection remains questionable for early-stage patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, serum TTR level can be 1 of the useful biomarkers for comprehending the severity of the illness in massively burned patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that pregnant women with an HbA1c of\u221a\u00a2\u201a\u00c4\u221e\u00ac\u20225.4% (36\\u2005mmol/mol) should proceed with an OGTT.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data identify novel affective and cognitive effects of varenicline and may have implications for medication development for other neuropsychiatric conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adolescent substance use may be indirectly prevented by selectively targeting childhood risk factors that disrupt the developmental cascade of adolescent risk factors for substance use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Micronutrient status shows differing relationships with age, gender and BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, different interventions should be developed to ease the patients' apprehension during this procedure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results underscore the need to re-invest in nursing services for health promotion for older clients receiving home care.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serving fruits in advance of other meal items may be a low cost easy to implement strategy for increasing fruit intake in young children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effects increased for individuals with more advanced cancer stages.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replication of these findings and assessment of long-term efficacy and safety of citalopram for treatment of neuropsychiatric symptoms in dementia are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The protocol developed at our hospital for the detection and management of HOS effectively addresses possible long-term complications arising  from poor nutritional status and chronic electrolyte alteration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to reduce self-harm in adolescents are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In TBI patients with diffuse injury and disturbed autoregulation higher levels of CPP may be beneficial.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survival benefit suggests that diabetes screening and maintenance of good glycemic control may improve outcomes in EC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CARD offers benefit to most patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several hospital characteristics are associated with LOS in psychiatric hospitals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ensuring sufficient serum 25-hydroxyvitamin D concentrations might play an important role in decreasing the risk of bladder cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend dexrazoxane as a cardioprotectant for children and adolescents who have malignancies treated with anthracyclines.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "N2O/O2 decreased pain with in-office hysteroscopic sterilization compared to oral sedation and is an effective pain management option for this procedure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Community nurses should assess  the at-risk population and provide effective preventive strategies and programs to reduce the prevalence of malnutrition and frailty.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fenofibrate may be a potential new therapeutic option for treating insulin resistance following severe burn injury.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, MTHFR A1298C polymorphism had a significant association with breast cancer in Caucasians.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CCM is a valid accurate non-invasive method to identify small nerve  fibre pathology and is able to diagnose DPN.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no evidence that the benefit of letrozole over tamoxifen differed according to patients' BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas kitchen and nursing-related aspects of nutritional care seem  to be widely implemented in German NHs, management and quality assurance demands  are often not met.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the beneficial impact of local anesthetics on breast cancer needs to be strengthened by additional preclinical and clinical trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gastrin secretion is diminished after RYGB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A 6-month physical activity program can positively influence physical self-esteem and the frequency of physical activity, both from a short- and long-term perspective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study of the epidemiological profile makes easy the diagnosis of pediatric dermatoses encouraging good history and search for prevention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although not without risk, it is generally a simple procedure leading to satisfactory weight loss, improvement in co-morbidities, and consequent reduction of the perioperative mortality and morbidity rates associated with surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longitudinal lipid levels differ between ICH cases and non-ICH controls, most notably for a decline in serum TC and LDL levels within 6 months preceding primary ICH, independent of statin or alcohol use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The long-term outcome of treated patients with supratentorial ganglionic hemorrhage with ventricular involvement and occlusive hydrocephalus is comparable to that of patients with similar hematoma volumes but no IVH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Potentially, this strategy should enable physicians to avoid thiopurine-related adverse effects and identify individuals who may benefit most from 6-MP maintenance therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depressive symptoms are more prevalent among cancer patients than in the general population, but they are generally under-diagnosed and under-treated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chitotriosidase activity determination has no value in the clinical identification of NPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, large-scale prospective studies on this issue are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-inferiority of CMR perfusion imaging to the current invasive reference standard (FFR) would establish CMR perfusion imaging as an attractive non-invasive alternative to current diagnostic pathways.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study revealed that the application of electro-acupuncture at EX-B2 and SP6 acupoints could be used as a non-pharmacologic method to reduce labor pain and shorten the duration of active phase of labor.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More research is needed to understand the complex interplay of these factors to inform multi-level interventions to address screening disparities for diverse LGBQ women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine radiation in unselected breast angiosarcoma should be cautious  because there is no survival benefit in primary AS and appeared to be associated with a worse OS in secondary AS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Psychological support including respiratory-sinus-arrhythmia biofeedback is an effective and simple tool that could be used by nurses to reduce state-anxiety and emotional stress in patients undergoing coronary angiography.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This general reduction in the size of the CC except for the rostrum was thought to be the result of cortical atrophy secondary to the disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, NIR light therapy may be a beneficial, noninvasive modality for improving muscle function during rehabilitation after musculoskeletal injury.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, obesity seems to be associated with more wound complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study shows an impact for only a limited number of brain dead donor resuscitation parameters on DGF duration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Condom use  did increase over time in both groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Especially employment, functioning and social support could be promising targets to facilitate adherence in patients with schizophrenia or bipolar disorder.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Uptitration of telmisartan more effectively reduces urinary albumin than addition of amlodipine in hypertensive patients with diabetes treated with a combination of telmisartan and diuretic for the same degree of BP reduction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These current findings suggest that levobupivacaine can be used as a substitute for bupivacaine for spinal anaesthesia in elderly patients \\xe2\\x89\\xa5 65 years of age undergoing elective TUR-P or TUR-M operations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should translate to better survival after cardiac arrest.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetes mellitus and first-degree family history of cancer are associated with an increased risk of sporadic PNET.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative histologic myocardial remodeling influenced the postoperative RV function in this group of patients with late repair.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that isovolumetric substitution of water or fresh juice for bottled juice was inversely associated with T2D incidence in a long-term prospective study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ACR Top 5 list is intended to promote discussions between physicians and patients about health care practices in rheumatology whose use should be questioned and to assist rheumatologists in providing high-value care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most students lack the necessary MHFA skills to support friends suffering from symptoms of depression, or to help them get appropriate support and prevent risk of harm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we suggest that lidocaine-diluted BTX-A may be a better treatment option for the patients with primary axillary hyperhidrosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, a large number  of benign biopsies were undertaken, with likely resultant psychological impact.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The influence of BMI on the prognostic value of CPX in HF requires further evaluation in longitudinal studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elderly women with a history of falls and with lower SBP levels should have more attention paid to the prevention of falls and related accidents.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential benefits of SV preservation can be safely accomplished in virtually 50% of contemporary men subjected to RP, if our tool's predictions are applied.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Educational programs should be developed in order to minimize this problem.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with type 2 diabetes at high risk for cardiovascular  events, degludec was noninferior to glargine with respect to the incidence of major cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Avoidance of complications should improve the cost-effectiveness of TAVR for inoperable and high-risk patients, but reductions in the cost of uncomplicated TAVR will also be necessary for optimal efficiency.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study showed that the MC procedure is a good alternative to the LC procedure, when postoperative quality of life is measured.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results demonstrate the existence of a progestogenic vasoconstrictive effect in the ophthalmic and central retinal arteries.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Notably, these results appeared magnified in high-risk patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Electrocautery may be used safely for RA harvesting in the forearm.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the benefits of absorbable suturing, we recommend this method in all open appendectomies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With rigorous hydration, the CIN incidence was very low in patients with moderate renal dysfunction who underwent coronary angiography or PCI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following intervention development, the PAC intervention was evaluated within a randomized clinical trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Detectable BPA plasma levels have been found also in our population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both open and closed establishment of the pneumoperitoneum are related to a potential danger of perforating lesions, but inserting the first trocar under direct vision allows early recognition and immediate repair.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of a multidisciplinary rehabilitation nutrition team increased the frequency of sarcopenia evaluation and practice of rehabilitation nutrition.J. Med.Invest.64: 140-145, February, 2017.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More liberal HbA1c testing should be considered in high-risk patients before elective surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, its extended use among the type 2 diabetic population, without a prior selection, does not seem to be justified.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "pCR is an independent predictor of favourable clinical outcomes in all molecular subtypes in a two-step multivariate analysis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results demonstrate the feasibility of conducting monthly Recovery Management Checkups with women offenders post-release and provide support for the effectiveness of using RMC to successfully link women offenders to treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neighborhood walkability-related attributes should be taken into account when promoting the use of existing parks or creating new parks.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because patients underwent cardiac surgery on the beating heart, these results could have implications for cardiac patients undergoing noncardiac surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low cost and unobtrusive nudges can be effective tools for food pantry organizers to encourage the selection of targeted foods.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports the option to substitute normal saline for ciprofloxacin in ears without an active ear infection at the time of tube placement, which would reduce both cost and unnecessary antibiotic use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, a large number of children had poor nutritional history or growth failure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity was significantly associated with cognitive impairment in euthymic bipolar patients, and it also appeared to affect cognition in the long term.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The HDL-raising allele of the LIPC gene (T) was associated with a reduced risk of AMD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Populations living in sub-Arctic areas may be adapted to face climate exposure during winter through behavioural protection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work will focus on evaluating  the mechanism of this outcome and documenting improvement in an objective, prospective manner.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, multimedia tools cannot replace personal interaction and should only be used to support daily work.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that a proportion of selective eaters continue from childhood into adulthood with similar eating patterns; new onset selective eating occurs in adolescence or young adulthood; and selective and non-selective  eaters at age 23 do not differ with regard to weight or eating psychopathology.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients who are motivated to quit smoking should be targeted for smoking cessation treatment after MI.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the occurrence of complications in our experience, TPTX followed by autograft and guided by intraoperative PTH monitoring represents a better surgical option in MEN1-HPT compared with other surgical approaches.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limitations include the possible modification of study findings in non-VA settings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that postmenopausal BMI is associated with increased circulating levels of parent estrogens and reduced methylation of catechol estrogen metabolites, the estrogen metabolism patterns that have previously been associated with higher breast cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This characteristic of EN coiling at this potentially tortuous location should be taken into account when selecting an endovascular strategy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It could be particularly useful in a stepped care approach, in which general practitioner or other mental health professionals can offer treatment to people with mild to moderate symptoms at low risk of suicide.Trial registration ClinicalTrials.gov ID: NCT02010619.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has relatively no side effects as compared to Intravenous diazepam and can be used as a first line agent for treatment of acute convulsions in patients with difficult intravenous access.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LSG reduced calorie intake both through volume of food and the calorie density of the food consumed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CAM is a treatment option for persistent inflammation following AOM and to prevent continuing otitis media with effusion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, additional furosemide therapy needs to be scrutinized in the therapy of these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ensuring pre-transport stabilization of neonates, the availability of adequately trained staff and the provision of appropriate equipment must be urgently addressed to improve the outcome of neonatal transport in resource-limited settings like Jamaica.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The importance of crying as a stimulus to SBS may provide an opportunity for preventive intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because this methodology is often employed to document antiplaque benefits of new and existing technologies, it is important to periodically evaluate and confirm its reliability and reproducibility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is recommended that individuals with PAD should undertake exercise as a form of treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to conduct appropriate interventions to improve self-acceptance among these women, based on an understanding of the factors associated with self-acceptance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that red light phototherapy alone can be a new therapeutic option for acne vulgaris.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "VSP Er:YAG laser resurfacing is a promising treatment option for SD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the importance of not making broad assumptions about OCD symptoms most likely to occur in an individual with comorbid tics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A-HIT1 and A-HIT2 are the first nationwide FH registries in Turkey and will provide important information on the management of Turkish FH patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A significant proportion of patients will cease statin treatment in the months prior to a colorectal or breast cancer death.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In children, a 'one-day' mobilization regimen consisting of one injection of 240 \\xce\\xbcg/kg plerixafor alone in hematological steady state provides a faster and shorter mobilization than in adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NMES is a feasible and effective treatment to prevent quadriceps muscle strength derangement during severe exacerbations of COPD and may be used to compliment early post-exacerbation pulmonary rehabilitation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrated that SCAP rs12487736 and rs12490383 were significantly associated with SBP and SHBP in overweight/obese Chinese children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results provide information on shared environmental and genetic risk factors for first and later cancers and may help to identify individuals at high risk for subsequent cancers, which will be important as skin cancer incidence continues to rise.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LAUNCH-HV, but not LAUNCH-clinic, significantly reduced BMIz compared with PC by posttreatment, indicating the need for intensive behavioral intervention, including home visitation, to address weight management in obese preschool children.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They also demonstrate that  physicians have unperceived needs relative to CVD management and that the chart audit served to identify shortcomings in their practice of which they had been hitherto unaware.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In low and middle-income countries implementing a public health approach to antiretroviral therapy treatment, an untimed plasma drug concentration may provide a practical method for early identification of patients with inadequate medication adherence and facilitate timely corrective interventions to prevent virological failure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMT ameliorates pHDL index and significantly improves anti-oxidative  function, as measured by PON1.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies and more detailed analyses, considering confounding variables and including a larger and homogeneous population, are needed to strengthen the argument for a link between lipid metabolism and atopy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The HEYMAN program demonstrated feasibility in assisting young men to make some positive lifestyle changes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data may have important implications for the clinical management of OAB patients previously treated with tolterodine ER.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may have important therapeutic implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In infants, mucolytics agents efficacy has never been demonstrated and some elements suggest poor safety (paradoxical bronchial congestion).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Developing and targeting overdose prevention education programs that provide information on risk factors and ways to identify overdose, as well as effective responses, including naloxone use and rescue breathing, for more frequently injecting networks may help reduce opioid morbidity and mortality in these most at risk groups.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because the majority of drug violation arrests in the United States are for marijuana, these findings have important implications for the management of a substantial proportion of the US community correctional population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Slowed processing speed can have substantial implications for independent  functioning, supporting the potential importance of early implementation of an exercise intervention among patients with breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High concentration oxygen therapy increases Ptco2 in morbidly obese patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The plasma UA levels in patients with OSAS did not show an overnight rise.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the pilot results, the intervention was feasible and promising for sexual rehabilitation and regular dilator use after RT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of experiential methods and integrating communication skills training with visits to health centres may help medical students to appreciate the importance of CSL.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ability of HDL to attenuate endothelial inflammation is impaired in acute MI, and this metric of HDL function may serve as a predictor of new MACE, even independent of HDL cholesterol and apolipoprotein A-I.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results revealed that the evaluation of malnutrition risk should be conducted in older persons living in the community.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the control individuals, females had a significantly shorter NT than males.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present meta-analysis confirms and reinforces the evidence of a diabetogenic effect by statins utilization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should be considered in the development of future Bikram yoga trials to facilitate higher levels of adherence, which may enhance health outcomes and inform community practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary patterns of the elderly population of Villanueva are departing from the traditional Mediterranean diet and though adequate consumption of fruits, milk/dairy products, oils/fats and sugar/confectionery has been achieved, cereals/grain products, vegetables and the meat, fish, eggs group consumption was below the desirable levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicians may need to prescribe proper wheelchair propulsion techniques for their clients to avoid accumulating impingement stresses in the shoulder joints.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MMF is effective for inducing remission in Chinese MPA patients and may represent an alternative therapy to monthly impulses of IVC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increases in levels of HDL cholesterol correlated with improved clinical outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a due need for identifying high risk individuals/families including BRCA1 and BRCA2 testings, biologically driven trials devoted specifically to this group.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be accomplished by optimizing patients adherence, using more potent statins, titrating current statin therapy to higher doses, or using a combined lipid-lowering treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carefully adjusted and well-conducted cohort studies would be useful to identify  the relative effects of dietary cholesterol on CVD risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than a third of patients in the immediate preoperative period for colorectal cancer exhibited malnutrition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modest increase in anger may be an adaptive emotional response in stressful environments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For clinicians and patients deciding to begin calcium+vitamin D supplementation, current use of hormone therapy should not influence that decision.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "4% articaine buccal infiltration can be considered a viable alternative to 2% lidocaine inferior alveolar nerve block in securing successful pulpal anaesthesia for endodontic therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adaptive goals outperformed static goals (i.e., 10,000 steps) over a 4-month period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The EDC can effectively be used as an alternative method to paper-based QNNs for data collection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also is the first to demonstrate shifts in choice patterns  for food and money using a brief mindful-eating training with adolescents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The exercise intervention significantly improved processing speed, but only among those who had been diagnosed with breast cancer within the past 2  years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with a low energy fracture of the foot or ankle were at particular risk for low vitamin D, especially if they smoked, were obese, or had other medical risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the administration of G biloba is recommended after acute ischemic stroke.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of BAHA has significantly improved the hearing handicap scores in patients with unilateral conductive or mixed hearing loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anticholinergic burden appears as a risk factor for both delirium symptoms and mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetic MN usually presents in ageing and clinically hypertensive patients and is associated with severe global glomerulosclerosis, IFTA, and afferent arterial lesions histologically.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings suggest general support of CTs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its application as a routine school meal may aid current national school based nutrition and deworming programs in Africa.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incorporating culturally centered individualized MT may be an effective intervention to reduce stressors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further testing in multiple sites is recommended.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pathologic response rates associated with this nonablative APBI dose regimen are  particularly encouraging and support further exploration of this paradigm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For basic laparoscopic training the cardboard box, costing nothing, is a simple and effective alternative, which can be used in conjunction with sophisticated video-laparoscopy equipment costing thousands of dollars.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epinephrine sprayed on the papilla may be effective to prevent PEP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several of the motor features of ET (tremor and imbalance) are independently associated with reductions in level of physical activity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lumbar plexus infusion is a reasonable alternative to epidural anaesthesia for total knee arthroplasty.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Modifying the home environment, specifically reducing RED foods and electronics, may be particularly important for FBT success.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CUSE was able to distinguish between benign and malignant breast masses with high sensitivity and specificity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effects of parenting, both positive and negative, persisted well into mid-adulthood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MRI allows the detailed characterization of the in vivo fate of lipid emulsions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Retinopathy prevalence in our obesity WHO III cohort is low.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Pfizer; ClinicalTrials.gov number, NCT00327691 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ICF can be used to classify goals in neuropsychological rehabilitation in MS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fasting time represents an independent factor for reduced LDL cholesterol and elevated triglyceride concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many hospitalised women are at high risk for breast cancer and we could not identify even a single woman who was using chemoprevention for risk reduction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Providing appropriate supportive information for each psychological stage should be considered for women underwent amniocentesis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hydrotalcite is a good option of on-demand therapy for NERD patients due to its cost-effectiveness and speed of action.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Total whole-grain wheat and rye intake, reflected by alkylresorcinols in plasma, was not associated with a lower risk of T2D in a population with high whole-grain intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A relatively brief interruption of HAART resulted in significant improvements in total cholesterol, LDL cholesterol, and triglyceride levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The appropriate use of intra-operative hydrotubation can improve the post-operative IUP rate, serving as a complementary procedure for the surgical treatment of fertility reversal.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A daily intake of approximately 0.7 g DHA increases LDL cholesterol by 7% in middle-aged men and women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other assays that capture different facets of DNA repair function may be needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have shown that normal pregnancy, irrespective of parity, is associated with significant changes commencing very early in pregnancy, continuing throughout pregnancy, and some of these changes persisted postpartum.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Menthol solution can be an efficacious, safe and tolerable therapeutic option for the abortive treatment of migraine.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improved cholesterol level monitoring may increase adherence and cholesterol management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The SNP (rs2839471) is suggested to be located in the frequent recombinant region within UMODL1.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Pooled analyses of already reported trials; NCT01288443, NCT01288469, NCT01266876, NCT01812707, NCT01507831, NCT01617655, NCT01623115, NCT01709500, NCT01644175, NCT01644188, NCT01730040, NCT01730053, NCT01644474, and NCT01709513).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger trials are needed to definitively assess the potential benefits of dietary interventions on pulmonary symptoms and function in patients  with asthma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physician recommendation is a key facilitator for vaccine diffusion in this region.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limitations to this study, however, suggest the need for replication and extension of these findings in the future.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, no predictive criterion of long-term results could be established, except initial clinical severity and clinical change one month after treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the subgroup of men aged 60 or more, the expected prevalence is between 4.3 and 8%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, first-line gefitinib should not be recommended for advanced non-small cell lung cancer (NSCLC) patients only based on clinical factors, due to a very small sample-size in our study.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risk test appears to be a more effective screening tool in our population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sanitary staff do not obey the no-smoking law in hospitals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As part of the health strategy to maintain normal BMI values and achieve overall quality of life improvement in MWL patients, clinicians and health policy makers should positively consider recommending BCPS in multiple anatomical areas.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Malnutrition is common in hospitalised patients with cirrhosis and is associated with higher mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Observed differences between review and routine pathology diagnoses illustrated the need for high-quality pathology reporting and also for standardized quality control.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cholesterol, LDL, or HDL were not associated with recurrence risk among all men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential, albeit small, risk of virus transmission and allergic reaction, however, needs to be taken into consideration, as with any blood transfusion product.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of this study showed that breast cancer is common and mostly affected women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These treatment advantages should be balanced against the occurrence of adverse events in the CNS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The efficacy and safety of everolimus plus trastuzumab and paclitaxel as first-line treatment for HER2+ advanced breast cancer in the Asian  subset was consistent with that reported previously in the overall population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effects of increased carbohydrate on FBS, serum insulin, triglycerides and VLDL-C indicate that a proper nutritional policy needs to be implemented for this population of rural, low-income Bengalis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigations should address the rationale for the early detection and control of glucose fluctuation in the era of universal statin use for CAD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor chronic nutritional status was associated with increased pathogen carriage in children <5 years of age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It must be considered before malnutrition onset, and, if necessary, before puberty.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These gains may be due to a training method that addresses the early perceptual impairments in the illness, that exploits intact mechanisms of repetitive practice in schizophrenia, and that uses an intensive, adaptive training approach.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of a fibrin glue with a low concentration of thrombin could be useful during wound closure and may decrease seroma formation in postbariatric patients undergoing lipo-abdominoplasty.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dexmedetomidine, Midazolam and Ketamine, all the three drugs evaluated in the present study can be used safely and effectively through IN route in uncooperative pediatric dental patients for producing moderate sedation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with type 1 diabetes who were receiving insulin, the  proportion of patients who achieved a glycated hemoglobin level lower than 7.0% with no severe hypoglycemia or diabetic ketoacidosis was larger in the group that received sotagliflozin than in the placebo group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Frequencies of DS participants presenting with strabismus, nystagmus, hyperopia and oblique astigmatism were not statistically different between those with CHD and those without CHD in this sample.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a close association between elevated lipids and hepatic  steatosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PN did not impact the overall time to completion of diagnostic care or the number of patients who reached diagnostic resolution of a cancer abnormality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adiponectin is shown as one of the mechanisms by which \u221a\u00e8\u201a\u00c4\u221e-3 improves  cardiometabolic profile in persons with cardiovascular risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that perioperative intravenous infusion of PUFA should be recommended for patients undergoing CABG.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinically significant desaturations occur in both regimens, indicating the need for operators to recognize and respond to the need for airway correction according to American Academy of Pediatric Dentistry guidelines.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies focusing on the relationships between gestational diabetes, obesity, and EC, including age at diagnosis, are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the assay used, changes in the GH peak response to GHRH+ARG were accompanied by changes in the IGF-I SDS, metabolic profile, and carotid IMT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may provide an additional phenotypic sign in HNPCC carriers, which could be used in first level CRC population screening programmes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mesenteric swirl is the best indicator of internal hernia after laparoscopic Roux-en-Y gastric bypass, and even minor degrees of swirl should be considered suspicious.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multi-level obstruction is more prevalent in obstructive sleep apnoea and is associated with increased severity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, screening for and helping people manage financial strain may boost the magnitude of intervention benefit for those with financial strain and should be explored as part of depression care.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that when performing spinal anaesthesia in pregnant patients, if the intercristal line intersects an intervertebral space then the space below should be chosen and if the intercristal line intersects a spinous process then the interspace below should be chosen.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The severity of poor glucose control among patients  with diabetes was also linearly associated with the risk of TB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with a PPW <43kg or a GWG <8kg  are at greatest risk for poor birth outcomes in this setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of LB PAI in TKA is a reasonable alternative to FNB, which avoids the additional weakness and other risk associated with FNB procedures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physicians should be aware that the risk of missing a polyp is related to patient factors (presence of > 2 polyps) and polyp factors (left colon location).", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vildagliptin is effective and well tolerated when added to a maximum  dose of pioglitazone, without increasing the risk of hypoglycaemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison with the paper patch method, PRF, a new method, provided more rapid healing with more successful audiological results, and with no requirement for a second procedure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Students' preference for the progressive practice schedule indicates that educators should consider this sequence for simulation-based training.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the amygdala hypoactivation observed in bipolar II depression is opposite to the direction seen in bipolar I mania and may therefore be state dependent, the observed orbitofrontal cortex hypoactivation is consistent with findings in bipolar I depression, mania, and euthymia, suggesting a physiologic trait marker of the disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both a low-fat vegan diet and a diet based on ADA guidelines improved glycemic and lipid control in type 2 diabetic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The implications for these findings are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings indicate that the CAPE-V can be used reliably and similarly by professionals who specialize in voice disorders.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The extended-dose CQ regimen can overcome 39% of resistant infections that would recrudesce under the standard regimen, but the high failure rate after directly observed treatment demonstrates its use is inappropriate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Systematic Review Registration: PROSPERO CRD42013004608.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recommendations of basic rules for metabolic support are made.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that less clinically intensive interventions such as peer education could be suitable for male and female condom promotion in populations already exposed to barrier method promotion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Standardized lipid testing in children with arterial ischemic stroke may further our understanding of this potential risk factor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies are needed to evaluate shared CVD risk factors and breast cancer outcomes because of missing health record information\\u2029.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nocturia and poor sleep are common among women with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ezetimibe 20 mg daily reduced total and LDL cholesterol further in patients receiving statin therapy compared with 10 mg daily.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have direct implications for preventive strategies, because the diagnostic utility of the antigen assay is compromised during receipt of prophylactic or empirical antifungal therapies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study show better improvement in acute LBP treated with LLLT used as additional therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with pure MN with DM can frequently achieve remission.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, surgeons should be aware of the potential for unexpected adjacent organ injury ( ClinicalTrial.gov identifier: NCT01203969).", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings also underscore the importance of conducting research on ways to prevent or reverse declines in physical functioning in this patient population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical CsA may be helpful in the treatment of meibomian gland dysfunction (posterior blepharitis).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased IR estimated by HOMA-IR was significantly associated with a higher remodeling index and positive coronary artery remodeling.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, peer outreach workers can be effectively trained to reduce health disparities by providing evidence-based brief counseling approaches targeting high-risk minority populations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since women at high risk for breast cancer may  only interface with the healthcare system at select points, all healthcare providers must be willing and able to do risk assessment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ClinicalTrials.gov Identifier: NCT02357420.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neoadjuvant chemotherapy followed by interval debulking surgery was not inferior to primary debulking surgery followed by chemotherapy as a treatment option for patients with bulky stage IIIC or IV ovarian carcinoma in this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prostate 77:549-556, 2017.\u221a\u00c7\u00ac\u00a9 2017 Wiley Periodicals, Inc.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only the vitrectorhexis and manual CCC are commonly used today.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "UACR-based HR was further modified according to eGFR level, with risk progressed with CKD stage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MTAD can be suggested as an alternative irrigant for pulpectomy of necrotic teeth.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strengthening this atypical relationship following atomoxetine treatment suggests an important pathway to treat attention-deficit hyperactivity disorder.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EG chemotherapy had similar clinical benefits to PG chemotherapy in terms of PFS but less neurotoxicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The U-AIM is valid and responsive to change and may help clinicians monitor CSU activity and track treatment effectiveness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data suggest that patients with psoriasis are more susceptible to vascular diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies in larger population sets are warranted as advanced screening and prophylactic intervention might be employed in GG carriers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "hANP should be part of the postoperative care for cardiac surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preconception counseling and clinical care to obtain a healthy weight prior to pregnancy along  with routine obstetric care on gestational weight gain is critical to improve birth outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our current analysis does not support the existence of an association between age at first childbirth and adult-onset diabetes among postmenopausal women, which had been reported previously.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although formal training may not be necessary for basic skills, formal instruction for more advanced skills, such as suture placement and knot tying, is important in developing skills needed for effective robotic surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it is important to develop strategies to keep participants who are at high risk in Web-based interventions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therapeutic thoracic medial branch blocks, with or without steroid, may provide a management option for chronic function-limiting mid back or upper back pain of facet joint origin.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that the GSTT1 polymorphism may play an important role in the pathogenesis of T2DM in the Brazilian population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuity of stiffness maps allowed for choosing multiple quantification ROIs which covered large areas of lesions and resulted in similar diagnostic performance based on average and maximum elasticity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health care institutions should consider how to address this patient concern as a part of routine quality improvement.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its effects were equivalent to Xuezhikang Capsule and Lovastatin Tablet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some DAN AP members are diving with medical conditions which could potentially impact the safety of their diving.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Severe DA in adolescence is a dental public health challenge and this study shows that DA is a hindrance to seeking dental treatment irrespective of dental status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preventing deterioration of malnutrition, coupled to early detection of HIV/AIDS with adequate antiretroviral treatment, and extending the duration of feeding supplementation, could be crucial elements for ensuring full  recovery and improve child survival in malnourished Zambian children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We support its use for at least 1 week after discharge.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the results of our study, these results still remain controversial, and then we need further and larger study to  get at the root of real causal effect of both relationships.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation In cardiac rehabilitation, especially in phase III, it is important to develop and to present alternative strategies, as virtual reality using the Kinect in a home context.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cord BDNF may partly derive from BDNF secreted by the placenta.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Child undernutrition is a major public health concern in the plantation sector, Sri Lanka.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it lacked adequate sensitivity and specificity to replace the two-step approach in the diagnosis of  GDM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, serum folate levels were decreased in postadolescent acne patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The deficiencies in death certification are rectifiable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It provided the evidence for association of SCAP with SBP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attention training with induction of the flow was associated with greater improvement of attention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(2) Teeth mesial to the agenesis site showed some delay in development compared to teeth distal to the agenesis site, in this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are no indications that endogenous and exogenous gonadal hormones affect the radiation dose-response relationship.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To be more precise, it is arguable that the focus of the theoretical foundations, used in new web-based PA interventions should depend on the intended program outcome.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite this, minor proximal migration still occurs in up to one quarter of fenestrated endovascular repair patients by 4 years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An intervention for parents and children to improve HS preschoolers emotional and behavioral self-regulation in combination with an obesity-prevention curriculum did not reduce obesity prevalence or most obesity-related behaviors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although there was no association of GSTM1 deletion polymorphism with susceptibility to T2DM, the influence of this polymorphism on important clinical parameters related to glycemia and blood pressure levels was verified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trial registration NCT01267097; clinicaltrials.gov.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a genome wide meta-analysis of two independent cohorts from UK and Finland, we identified potential associations at three distinct loci.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates that the level of self-acceptance among women with breast cancer in China is low, and suggests that there is room to improve.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ability of pramipexole to inhibit aversive processing might potentiate its adverse behavioural effects and could also play a role in its proposed efficacy in treatment-resistant depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Research to identify more accurate (bio)markers is needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biological therapies increased the level of the anti-atherogenic lipid apoA1.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Policy makers should consider deploying IRS in combination with ITNs to control transmission if local ITN strategies on their own are insufficiently effective.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When able to be obtained, MFA results do not reflect the extent of proteolysis but are indicative of the state of cellular energetics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, very old adults should follow a long-term and systematic routine of exercise throughout life, in order to improve and maintain their physical functions and to ameliorate their life status.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although more complications occurred after discharge in the fast track care group, this did not lead to adverse outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TCs should be routinely applied during cephalometric radiography if cephalometric analyses are limited to the structures above the second cervical vertebra.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transcervical amnioinfusion in labour for meconium-stained amniotic fluid is a simple, safe and easy-to-perform procedure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During neoadjuvant therapy for esophageal cancer, self-expanding metal stents are safe and effective in relieving dysphagia and maintaining nutrition.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Severe childhood diarrhea is mostly caused by rotavirus infection.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This complex interplay between retrieval experience and time holds implications for measuring learning outcomes and for scheduling practice in classrooms and clinics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Malnutrition status in priests admitted to the Priest Hospital should be concerned and be properly managed for improved clinical outcome.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2017;123:948-56.\u221a\u00c7\u00ac\u00a9 2016 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger studies are warranted to verify the impact of obesity on outcomes and to elucidate any underlying clinicopathologic/biologic factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings may be used to facilitate the prognosis of future patients with RRD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence are important risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is a recently recommended approach and your study confirms its efficacy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treadmill walking combined with obstacle-crossing training may help improve the walking ability of patients with hemiplegic stroke and can possibly be used as an adjunct to routine rehabilitation therapy as a task-oriented practice based on community ambulation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison to ranibizumab, conbercept shows a longer treatment interval and fewer intravitreal conbercept injections are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Amendments to the FMS tasks and/or scoring method are needed before it can be used for reasons beyond appraising the ability to move freely, symmetrically, and without pain.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Teachers should, therefore, be encouraged to educate children from an early age about oral hygiene promotion.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanisms for the changes in food preferences may involve both unconditioned and conditioned effects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For this, its important that nutrition studies and, more importantly, control interventions take into account this spatial heterogeneity in the distribution of nutritional deficits and their underlying associated factors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We need to understand why the target population seems inured to the health message that childhood obesity is a significant health-care issue and identify the barriers to seeking help and then acting on positive health behaviour retraining.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In accordance with its use in Tibetan Medicine, these preliminary findings suggest that Agar-35 may benefit aspects of psychological health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This agent may provide an alternative for the treatment of hyperphosphatemia in CKD 5D patients in mainland China.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Iron nutrition and stress exhibited a positive association through hepcidin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DM is associated with poor outcomes in patients undergoing hepatectomy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results accentuate that no longer one size of care delivery fits all, care must be responsive and adaptable to meet the individual needs of people affected by cancer to thrive.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This in situ analysis confirms that IL-6 is not a key player in the pathogenesis of inflammatory processes in spondyloarthritides (SpA).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional measures such as reducing medication costs and patient education are required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many children with achalasia relapse after initial treatment, undergoing multiple, different procedures, despite which symptoms persist and impact on quality of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alternative dosing strategies in the obese patient population should be examined in rigorous clinical trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The benefits of ramipril observed during the active period of the HOPE trial were maintained during posttrial follow-up for cardiovascular death, stroke, and hospitalization for heart failure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depending on availability, either compound can be used as an adjuvant for pain control in this setting.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrasound measures of fetal size and growth used in this study are not sufficiently accurate to predict those infants likely to be at risk from the  adverse effects of fetal hyperinsulinaemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Decision makers should decide whether the clinical benefits of integrated care on the short term outweigh the higher costs compared to usual care.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ability to predict a response to treatment based upon pretreatment parameters was not consistent between groups; thus, prediction of treatment outcomes based on pretreatment measurements should be carefully evaluated for each treatment modality.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings need replication in a larger sample.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Red crowding bars surrounding black optotypes are an acceptable alternative to black crowding bars for the measurement of visual acuity in amblyopic eyes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To simplify ART initiation and reduce the risk of suboptimal dosing, full-dose nevirapine at ART initiation should be considered for African HIV-infected children less than 2 years of age.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed an association between EH/EC and a history of gestational diabetes specific to younger women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative nutritional status is a risk factor for SSIs in CRC, and its proper preoperative management may reduce the risk of SSIs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonengagers and nonretainers share similar high-risk traits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results are consistent with gastrointestinal motility effects of TZP-101, supporting further investigation of TZP-101 in the management of severe gastroparesis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An individualized risk stratification approach in children with severe obesity should be based on presence of complications rather than simple BMI cutoffs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be the task of physicians to warn potential consumers, especially in connection with drinking and driving.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High FGF21 values in our patients are correlated with atherosclerosis risk factors: hypercholesterolemia, hypertriglyceridemia, hypertension, increased TST and increased levels of sTWEAK.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implantable gastric stimulation as a surgical option for the treatment of morbid obesity is a less complex procedure than current bariatric operations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RLS is prevalent in the general population in Sweden.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the limited sample size did not permit specific analyses of lower birthweight (e.g. < 1500 g) newborns.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This preliminary study, suggests urinary TGF-Beta-1 and NGF as a potent marker in children with NDOA, as they decline following BoNT-A injection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A MNA score of less than 8 performed better than the SGA, Braden Scale, and  plasma arginine levels in predicting PU development.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In spite of our main negative results, it is important to continue investigating on the relation between textiles and skin disorders to improve patient well-being.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This provides the potential management guidelines  for a NML\\xa0in screening patients and further prospective studies in a large, multicenter screening population are required.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is improvement of GERD as assessed by symptom questionnaires, as well as improvement in grade of esophagitis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to encourage weight loss may need to be considered seriously prior to open ventral hernia repair, especially for patients with body mass index >40\\xa0kg/m2.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, uncertainties about its clinical and cost effectiveness can only be fully answered by further examination of its superiority against other treatments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The DCE had a differentiating effect on the relative importance of the attributes; however, determining relative importance using DCE should be done with caution as a lack of statistically significant difference between levels does not necessarily imply that the attribute is not important.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study highlights the role of total cholesterol and blood inflammatory marker levels in enhancing ETP in morbidly obese patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alogliptin 25\\u2009mg once daily reduced HbA1c and FPG and enhanced clinical response compared with placebo when used as monotherapy or as an add-on  to metformin or pioglitazone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adverse events were mild to moderate, did not interfere with improvements in attention, and rarely led to discontinuation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The obesity paradox does exist in patients undergoing vascular surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ApoA-I and apoB are indicated as risk factors for cardiovascular and, possibly, cerebrovascular diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary diversity score is a valid indicator to evaluate micronutrient inadequacy in Chinese children, though there is still room for improvement of the method.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Iron deficiency anemia and vitamin D deficiency improved with iron and vitamine D supplements.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participation in a daily physical activity program not only reduces  adiposity but also improves childrens cognitive function as demonstrated by an inhibitory control task.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also provides support for traditional Chinese wisdom, which promotes meditation as one way to improve health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prior to  publication of monitoring guidelines, patients initiating treatment with SGAs did not receive adequate metabolic monitoring routinely, nor did SGA treatment appear to trigger additional monitoring.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results provide insight into the timing and magnitude of changes in theoretically and clinically important variables and may help patients anticipate when to expect improvement in craving and negative effect.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After the successful treatment of a DFI, recurrent episodes are frequent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest the importance of interventions to support adherence that target early non-adherence with LTBI treatment, particularly in the first 2 months, when there is a substantial risk of default.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study showed that IMT and PI of CCA, and anteroposterior  diameter of the infrarenal abdominal aorta and femoral-IMT were higher in patients with PCOS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A SET programs consisting of at least two training sessions a week, each lasting over 30 minutes, should be offered during the first 3 months of the SET program to optimize improvement in terms of maximum walking distance.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is one of the first proofs of concept showing that a nutrition-sensitive agriculture value chain approach can contribute to improved child nutrition in a remote pastoralist population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, low-flow anesthesia and TIVA can be used more safely in middle ear surgeries, provided that a well-equipped anesthetic device and appropriate monitoring conditions are available.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the high prevalence of cardio-metabolic disorders in major depression, exercise training may be recommended as an additional treatment component.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GDM is associated with lower cord blood apelin levels than control subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EN is suitable for a variety of childrens digestive diseases, which  can improve the nutritional status of the patients and was safe for clinical application.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chordal cutting improves mitral valve leaflet mobility and reduces mitral regurgitation recurrence in patients with ischemic mitral regurgitation, without any obvious deleterious effects on left ventricular function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we can use aromatherapy during perioperative periods in order to meet the expectations of the patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Loss of patency  of the PA drainage pathway may be an important predictor for symptomatic recurrence of PA cholesterol granulomas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strategy for failed lysis should be mandated as part of thrombolytic-based ST-segment elevation myocardial infarction protocols.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrated how tested SNPs make differential contributions to obesity and overweight risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caesarean section in a first pregnancy appears to protect against pelvic floor surgery in later life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at clinicaltrials.gov as NCT01678716.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One year after the diet therapy intervention, the beneficial effect  of the LCD on reduction of HbA1c and BMI did not persist in comparison with CRD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The minor differences between the completers and the non-completers  suggest that our retention strategies were successful.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prepectoral reconstruction can be safely performed in patients with a BMI < 40 and in patients having postmastectomy radiation therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, CT heterozygote seems to be associated with a lower risk of T2DM than CC or TT genotype, especially in male older adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All outdoor activity without clothes should be limited to 20 minutes to avoid skin damage.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The EVLA procedure may be superior to RFA in certain respects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The implication was that the provision of extra physical therapy does not necessarily improve the motor function of a young child with cerebral palsy and additional family support should not automatically be assumed to be beneficial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Xylitol-containing chewing gums can be used as an adjunct to regular home care preventive procedures to prevent dental caries.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most POPs were positively but not significantly associated with incident diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help explain the associations observed between different fat distribution phenotypes and coronary heart disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The LVO score may be a useful screening approach to identify LVO in patients with ACS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A family approach should be incorporated, reinforcing its role for healthy development.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data emphasize the importance of radiotherapy techniques that limit MCRD during breast cancer treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Supplementation with L. reuteri 6475 should be further explored as a novel approach to prevent age-associated bone loss and osteoporosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over the dose range studied no dose-response was observed so the selection of dose should be based on the dose effective to release steroids in the glucocorticoid pathway if this study is to be used in conjunction with such evaluation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity is associated with significantly younger age at time of primary THA and obese patients are likely to experience a higher rate of peri-operative complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present data suggest that elastic resistance exercise exerted benefits on the body composition, MQ, and physical function in patients with sarcopenic obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, hypovitaminosis D seemed to have a negative impact on long term excess weight loss, but not on short-term outcome or postoperative complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Home rehabilitation is a useful, equivalent alternative to outpatient rehabilitation in patients with COPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This needs to be taken into account when evaluating interventions at community level.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its unprecedented mechanism of action may offer a new opportunity for the treatment of BPH.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results might have implications for CTC as a CRC modality for opportunistic screening in average-risk adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gender differences in falls show an association with poor self-rated health, tiredness and pain in the hands, elbows, legs or knees.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combined therapy of mental practice and modified constraint-induced movement therapy could be used as a clinically useful intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This association remained in patients with recent hormone use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BC risk in female HL survivors increases linearly with radiation dose.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 3M barrier film may be helpful against dermatitis associated pruritus.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary sodium balance and circulating RAAS activity did not appear to affect this relationship.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnant smokers willing to try using ISCI may particularly value an engaging intervention offering a high degree of targeting of comprehensive information to them as a group and tailoring support and advice to their individual needs, as well as one providing post-relapse support, peer-to-peer communication and personal support from experts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Messages focused on diabetes were effective at increasing enrolment  in a healthy food programme.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL RELEVANCE: Community nurses should pay attention to the nutritional conditions of community-dwelling elderly persons.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A subset of CU patients remains poorly controlled that indicates an unmet need for novel therapeutic agents.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HRT does not appear to increase BC risk for HL survivors with therapy-induced early menopause.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, carnosine could be a safe and effective strategy for treatment of pediatric patients with diabetic nephropathy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Targeting may maximize reach and improve affordability of complex care management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deferiprone-containing chelating agent may have a protective effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This paper provides a window into side effect monitoring practices prior to the widespread promulgation of guidelines and associated quality improvement efforts and serves as a benchmark for future interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sexual counseling helped women maintain stable sexual function on aromatase inhibitors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modified AMD needs further evaluation on its efficacy and safety before its further use can be recommended.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are necessary to clarify if there is a causal association of immunoglobulins in prediabetes or if they reflect early immunologic disturbances in these patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide support to the hypothesis that nicotine may be the primary pharmacological agent responsible for genital hemodynamic disruption, thereby facilitating a cascade of biochemical and vascular events which may impair normal sexual arousal responses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Infant massage could help to reduce bilirubin levels and increase defecation frequency in neonates receiving phototherapy for jaundice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There may also be scope to reduce barriers to accessing non-English information and alternative communication strategies may benefit participants who are less inclined to weigh up advantages  and disadvantages as part of their decision-making.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Monthly SP and daily TS may not be appropriate in areas with high transmission intensity and frequent resistance to antifolates.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the ASD shape, as well as the size, should be considered when the device size is determined without SBD measurement.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The determined interactions might result in differences in the risk conveyed through Hcy with regard to disease development in those with unfavorable GGT concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intervention was acceptable, flexible and readily implemented in primary care consultations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This difference in functioning appears to be largely explained by diabetes-associated neuropathy, differences in exertional leg symptoms, and greater cardiovascular disease in patients with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is associated with a minimal risk of leakage, bleeding, and nutritional deficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the limited number of cases in this cohort with JRA-associated ophthalmologic complications there was no resulting loss of visual acuity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a favorable effect of BS on the hypothyroid bariatric population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "japonicum vaccine targeting bovines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The girls became overweight by the age of 5 years, whereas the boys only after 8 years of age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite of the documented strong inverse relationships between Diabetes Mellitus (DM) and male/female fertility, and also between IR and female  infertility via ovarian functions as in polycystic ovary syndrome, to our knowledge, there is no report about any influence of IR on male fertility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low educational level is confirmed as an independent risk factor, but belonging to a family that receives government assistance can be interpreted as a social marker of families and/or areas lacking of government intervention to increase access to breast cancer control programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Home nutritional advice during the first year of life decreases caries incidence and severity at four years of age in a low income community.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings imply that if the observed use of the sit-stand workstations continued over a longer duration, sit-stand workstations may have important ramifications for the prevention and reduction of cardiometabolic risk in a large proportion of the working population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did  not differ significantly between patients who received exenatide and those who received placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This information may be useful for targeting more accurate management strategies for these two different groups of colonised preterms in NICU.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consequently, tranexamic acid can be used safely and effectively to reduce bleeding resulting from CS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efforts should be made to raise awareness about the potential of such freely accessible treatment options among GPs and patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A minor increased risk of breast cancer was found in women with a history of uterine myoma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that switching from rosuvastatin to another non-equipotent LLT may impart an increased risk of AMI and should be avoided.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In high-risk patients with dysglycemia (prediabetes and early diabetes), mild and moderate chronic kidney disease significantly increased cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence and severity of ERM was not affected by RZB treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of PN became apparent beginning six months after detection of the abnormality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The research reveals that practical barriers and attitudes towards general health check-ups are important factors to take into account in determining African migrant womens participation in breast cancer screening.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By identifying these characteristics, we  can develop programs and materials that meet these populations needs and behaviors, ultimately increasing mammography screening and follow-up rates among  underserved populations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this controlled prospective study, metastatic SN patients with both a \u221a\u00a2\u00ac\u00a9\u00ac\u03a910% probability of metastatic non-SN with the MSKCC nomogram and a Tenon  score \u221a\u00a2\u00ac\u00a9\u00ac\u03a93.5 failed to identify patients at low risk of metastatic non-SN when completion ALND was not systematic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of patients who undergo surgical drainage of PA cholesterol granulomas remain symptom-free after surgical drainage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LEVEL OF EVIDENCE: Level III, retrospective comparative study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study has significant clinical implications, providing a simple behavioral tool that can be used to decrease and prevent psychopathology.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The distribution of high blood pressure subtypes in boys differed from those in girls, and boys with adiposity showed a higher risk of high blood pressure than their female counterpart.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interprofessional care teams are associated with improved diagnostic acumen and wound healing outcomes over conventional community care services.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: NCT01404676.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In T2DM patients, non-surgical periodontal treatment improved systemic oxidative stress balance and QOL, but did not decrease HbA1c levels at 3 months follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A reliable estimation of calcified atherosclerotic burden of the thoracic aorta can be achieved with modern tin-filter CT at dose values comparable to chest direct radiography.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "People starting at low potency should switch to a moderate pattern; more intensive therapies should be considered in who require a larger LDL-C reduction to reach therapeutic targets, patients with good treatment adherence who do not achieve the goal with a moderate pattern of therapy or patients at very high risk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with OHS, a 3-month comprehensive rehabilitation programme, in addition to NIV, resulted in improved weight loss, exercise capacity and QOL at the end of the rehabilitation period, but these effects were  not demonstrated at 12 months, in part, due to the limited retention of patients  at 12 months.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings provide evidence for the promotion of repeated exposure to vaccine messages emphasizing vaccine efficacy, normative support, and susceptibility to influenza.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considerations of both the 6-month clinical outcomes and the estimated 5-year cost-effectiveness suggest that EVLA should be considered as the treatment of choice for suitable patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Closer attention should be paid to this symptom in clinical practice, with more done to standardize its measurement and understand its origins, with a view to improving treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was not associated with any dyslipidemic changes as the lipid parameters were not elevated in them compared to the healthy controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study a BMI \u221a\u00a2\u201a\u00c4\u221e\u00ac\u202235 is an independent predictor of mortality and is associated with an inferior early functional neurologic outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low BMI, anemia and hypoalbuminemia were associated with attrition, and with a deficient nutritional  and immunological status at baseline, as well as during treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depression screening and systematic depression treatment should become routine components of diabetes care.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The benefits of Gd-EOB-DTPA-MRI due to less additional imaging and similar diagnostic workup costs in the three groups suggest that Gd-EOB-DTPA-MRI should be the preferred initial imaging procedure to evaluate hepatic resectability in patients with CRCLM.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Schools should consider adopting these practices to reduce days lost to common illnesses.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of the strategy may be effective in other clinical areas when free text entries are required.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prior cultures should not be used to narrow the spectrum of empiric antibiotics.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this phase 1 trial, no serious adverse events were observed with  inclisiran.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies are required to determine the clinical implications of this observation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is urgent need to pay more attention to developing consultation-liaison psychiatry services in trauma units of Nigerian hospitals, including orthopedic hospitals located in different geographical zones of the country.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cryoprecipitate has attendant risks, and it is appropriate that transfusion be restricted to situations with good evidence or sound principles to underpin use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future randomized prospective studies may generate stronger evidence, with a standardization of surgical indications and operative techniques.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the thrombotic risks of menopausal hormone therapy, this should be used only in women with significant vasomotor symptoms.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elecoroacupuncture at Hego (LI 4) can be adopted for treatment of dystocia due to abnormality of force of labor.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative SRS was associated with the highest rate of RN.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lidocaine may be helpful in decreasing ischaemic pain in patients with critical limb ischaemia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obese patients have a higher mean IOP and lower flow velocity than non-obese patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite robust methodology, real-life data are exposed to important potential biases, and therefore, results need to be treated with caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Total, HDL, and LDL cholesterol, triglycerides, diastolic blood pressure, pulse pressure, glucose, and triglycerides/HDL ratio differ between patients with EA and controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum therapy (AS/UCS) helps in the faster reepithelialization of postkeratoplasty ED as compared with AT and may be considered as a treatment option for early epithelial healing.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicians and researchers should be aware that both the nature and extent of symptom reporting is greater when using questionnaires than when athletes are interviewed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect should become manifest when a deep level of submersion (e.g., 8 cm water) is used.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biochemical tests at initial presentation followed by vitamin D assay at 6 weeks and calcium, phosphate and ALP assays at 6 months is recommended in the monitoring of these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by M\u221a\u00c9\u00ac\u00a9decins sans Fronti\u221a\u00c9\u00ac\u00aeres Operational Center Paris; ClinicalTrials.gov number, NCT01613547.)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other studies should confirm these findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In long-term home PN patients, higher zinc and selenium doses may be necessary to maintain their normal serum concentrations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results illustrate the importance of formal evaluation and monitoring for unintended consequences of programmatic interventions intended to improve prescribing habits.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obese children have worse OSA, behavioral problems, and quality of life than normal-weight children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with diabetes and cardiovascular disease or cardiovascular risk do not benefit from the addition of aliskiren to standard medical therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABCB1 1236 TT genotype and older age might be a predictor of PIPN, which diminishes quality of life of cancer survivors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may have implications for emergency research in various disciplines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endometrial scratching can be used as a low cost-effective tool to improve clinical pregnancy and ongoing pregnancy rate in IUI cycles.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To confirm this, further research needs to be undertaken.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest neurotoxic effects of prenatal tobacco exposure on newborn neurobehavior.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to reduce occupational stress and problems should form part of the training provided for clinical embryologists.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aerobic exercise added to dietary weight loss can attenuate the loss of ALM during weight loss and may be effective for the prevention and treatment of sarcopenia among overweight and obese postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These preliminary data cast doubt on whether colposuspension should be performed during sacropexy for severe urogenital prolapse as prophylaxis for postoperative incontinence because it seems to emerge as overtreatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prepectoral reconstruction is a viable alternative to partial subpectoral reconstruction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Performance incentives and external influences were more powerful modifiers of practice behaviours than the POC device in relation to CVD risk assessment completion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This research provides a clue that bone-targeting properties of bisphosphonates can be harnessed along with regenerative materials to potentiate osseous regeneration.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that one should consider an alternative method of gate cannulation if it has not been accomplished within this time.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oesophageal cancer patients should be assessed regularly and should be supported on an ongoing basis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The long-term implications for other health outcomes remain to be determined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An inverse relation was revealed between change in BW and PAL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This method used a smartphone with widespread availability and ease of transportation, which can be used by health professionals as a non-pharmacological method in the management of pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Visual and anatomic gains achieved at month 6 were largely maintained through month 24.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medical records lacked information on signs/symptoms of IBC, especially erythema and edema, when compared to the case-control study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A public health intervention promoting the use of free PDPT substantially increased its use and may have resulted in decreased chlamydial and gonococcal infections at the population level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Assessment of weight loss prior to MM  diagnosis should become a standard component of the clinical history in patients  with newly diagnosed MM.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To manage mild/moderate diabetic-ketoacidosis in children/adolescents, subcutaneous rapid-acting insulin aspart is an alternative to intravenous infusion of regular insulin.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest a need for individual, comprehensive survivorship care plans to effectively address symptoms that impact work ability and, ultimately, the quality of life of cancer  survivors.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TE doses in home PN should be individualized and adjusted based on regular monitoring of TE status.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The role of systematic supplementation before bariatric surgery has to be explored in prospective studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The recommendation for inclusion of supper should be individually tailored and not mandatory.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general in Poland, the PCOS phenotype is more severe in women living in rural areas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "YuangongCu365 is the most effective of the three devices and be used provided it is economically affordable.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deep anterior lamellar keratoplasty surgery is a viable option for macular corneal dystrophy without endothelial involvement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The treatment effect observed in the calcium+vitamin D+hormone therapy combination group may be additive rather than synergistic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An HbA1c level of 6.5% or higher in patients presenting for coronary artery bypass grafting was associated with a significant increase in the incidence of deep sternal wound infection and respiratory complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Teletriage callers were confident in the advice provided and were willing to continue to use the service.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study has enhanced our understanding of the determinants of underweight in the prison population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show a 2% upgrade rate to malignancy of pure FEA lesions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of a Charcot-related foot wound at presentation increased the likelihood of a major lower extremity amputation by a factor of 6.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The transvenous approach is less invasive and should be considered the standard procedure for patients without renal insufficiency.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Total laparoscopic  hysterectomy is associated with shorter hospitalizations and lower odds of blood  transfusion across the BMI spectrum, particularly in women with small uteri.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetic PD patients with retinopathy were at two times risk for overall cognitive impairment, executive dysfunction, impaired immediate memory and visuospatial skill as compared to non-diabetic PD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although all relapses were related to PR3-ANCA increases, reduction or withdrawal of immunosuppression without relapse was also related to increases and may explain the lack of predictive value of sequential PR3-ANCA determinations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential to prevent infection is increased when wounds are desloughed and MRSA is eliminated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this retrospective study, gross total resection with SRS was associated with significantly reduced LR compared with SRS alone for patients with large BMs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the number of patients in this study was limited, and prospective studies in larger cohorts are required to confirm these  findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Developing and applying interventions to enhance self-efficacy may help to sever the link between Type D personality and poor outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High TG and low HDL-C levels may contribute to residual cardiovascular risk in patients with well-controlled LDL-C levels; however, non-HDL-C levels at admission did not seem to be predictive for patients with ACS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The nomograms based on the analysis of the SEER database were superior to the TNM staging system in predicting the clinical outcomes for g-NEN patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further longitudinal studies are needed to confirm our results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Novel strategies for influenza vaccination in this population are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In spite of therapy, malnutrition is associated with negative clinical and treatment outcomes which suggests that HAART may not be sufficient to address co-existing nutritional deficiencies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with recurrent GB treated with SIACI BV, the change in ADC value after treatment is predictive of overall survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This subtle benefit of oral steroids in NAAION is clinically unimportant and does not provide support for its use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In human, however, transdermal application to the breast skin provides  local delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, adequate post-operative analgesic strategies should be employed due to the possibility of intense pain in the first 24 hours.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of dietary supplements in this population reflects that of other countries.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Midazolam should be administered at a dose of 0.06 mg/kg and the endoscopy should be initiated 30 s after midazolam injection for appropriate effects without any side-effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intentional weight loss shows mixed effects on circulating biomarkers, tumour gene expression, and proliferative markers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is simple to use and can be adopted as a public health strategy for identifying people with undiagnosed diabetes for early intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Protection from UFs by T2D exposure was observed regardless of medication type with slightly more protection among insulin users.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cervical cancer incidence is decreasing in Girona, although the dates of the screening histories suggest that it can be further reduced.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High dosages of proton pump inhibitors are associated with an adverse outcome in patients with spontaneous bacterial peritonitis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The apparent decrease in fluvastatin exposure on administration with ezetimibe was likely to be due to the parallel study design and two pharmacokinetic outliers and is considered of no clinical significance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that change in PASAT associated more with GM than WM pathology, and that treatment strategies oriented toward GM volume preservation may play an important role in prevention of cognitive deterioration in CIS patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mindful eating is a beneficial strategy to reduce impulsive food choice, at least temporarily, that may impede weight gain.(PsycINFO Database Record", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pathological mother-child relations, lower parental education levels, and smoking may be predictors of childrens overweight/obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support considering selected HIV-infected patients for allo-HSCT when indicated for the management of their hematologic malignancies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICALTRIALS.GOV IDENTIFIERS: NCT00394901, NCT00553475, NCT00407745, NCT00424372, NCT00553280, NCT01202227.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is imperative that residency programs implement a simulation curriculum and continue to train throughout the academic year.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current available evidence from prospective studies suggests that there is an inverse association between Lp(a) concentration and risk of type-2 diabetes, with a higher risk of type-2 diabetes at low Lp(a) concentrations (approximately\\xa0<7\\xa0mg/dL).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a post hoc analysis from 10 ODYSSEY trials, greater percentage reductions in LDL-C and lower on-treatment LDL-C were associated with a lower incidence of MACE, including very low levels of LDL-C (<50 mg/dL).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(A Study to Evaluate the Efficacy and Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial Hypercholesterolemia HYDRA; NCT02226198).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vitamin D-deficient and iron-replete children had longer duration of infection, although this association was lost with age adjustment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings bring the effectiveness of acromioplasty into question and may support the idea of a more conservative approach in the initial treatment of SAPS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Detection of these functional and/or structural abnormalities are important in predicting prognosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cola consumption may not increase stone risk and may be an acceptable alternative source of daily fluid for patients unwilling to increase water consumption.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall increase in immunization coverage can be attributed to use of SMS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with stable weight had longer survivals than patients who lost or gained weight.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These measurement methods and relationships between provider performance measures may be useful to state Medicaid programs that seek to contain costs, enhance coordination of care, and improve health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a need to investigate BCT implementation beyond simple presence/absence to identify protocol refinements or required BCT training.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated serum concentrations of cardiac biomarkers were common in youth with type 2 diabetes, but their clinical significance is unclear and will require further long-term study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is a manageable condition that develops weeks to years following breast reconstruction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The BDI is a significant predictor of long-term outcome among patients admitted to the Breast Cancer Diagnosis Unit in Finland.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides, the relationship between increase of dietary  diversity and risk of obesity should be treated circumspectly.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should be considered in the context of physician education and training in light of increasing health care costs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relationship between IOP, glaucoma, and  obesity deserves further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicated that the impairment of interaction between insulin and its high-affinity receptors in erythrocyte membrane might be a critical pathophysiological event in the development of breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tailored messaging for pneumococcal vaccination through telephone reminders increases patient demand for vaccination and should be implemented by managed care organizations seeking to increase their vaccination rates.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultraprocessed food consumption was associated with a higher risk of overweight and obesity in a prospective cohort of Spanish middle-aged adult university graduates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We therefore recommend further study to develop a more robust estimate of blood transfusion and the risk of HIV in pregnant women in Nigeria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is unclear how much of this is appropriate given that evidence-based clinical guidelines recommend monotherapy with ADs in the treatment of major depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combining the provision of information with emotional support may be particularly beneficial.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We developed a method to quantitatively assess cytotoxicity of the NK cells and CTL by measuring the expression of CD107\\xce\\xb1 on the cell membrane, which appeared to be an effective and rapid screening test for cytotoxic defects-related diseases such as FHL and other HLH secondary to primary immunodeficiency.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Behavioral weight loss programs should be considered an effective option for this population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hydroxychloroquine use was associated with lower lipid levels but not with the plasma glucose in this RA cohort.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that depression, anxiety, hostility, and stress are not related to coronary-artery calcification and that somatization is associated with the absence of calcification.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Arthroscopic-assisted partial humeral head resurfacing, which has the advantages of bone stock preservation and the maintenance of an intact subscapularis tendon, allowed immediate postoperative mobilization and provided significant improvements in subjective outcomes, especially for pain relief in active patients without severe glenoid cartilage wear.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Levels of cholesterol fractions in patients with JIA were found within the normal range.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that the KVC, but not the KVNC, could be used as an alternative device for intubation by novice personnel.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A paper chart based clinical reminder providing update clinical recommendations could modify the doctor's behaviour and improve the attention to lipid levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Visual and force feedback show promise as 2 modalities that could be used to decrease trunk compensation in stroke survivors during reaching tasks.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PDT can be performed safely in obese patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this clinical study showed that GIC (EQUIA; GC) can be used for the restoration of permanent teeth and may be more appropriate for certain clinical situations than the resin composite material.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies to confirm the role  of premenopausal hormones in the etiology of both premenopausal and postmenopausal breast cancer are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "H pylori is neither a cause of IDA/ID nor a reason for treatment failure of iron supplementation in young Bangladeshi children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "iCBT for depression is an efficacious, accessible treatment option for people with diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be considered as a valuable tool for myocardial protection protocols.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High HFIS prevalence was reported among urban Lebanese households.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Enhanced screening of LDL-C levels and the use of statins at highest tolerated dose and concomitant combination therapy is recommended in order to achieve LDL-C targets  outlined by current guidelines.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of beta-blockers was associated with a reduced risk of fractures in middle-aged and older subjects from the general population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An early start to the prevention of abdominal obesity  is of particular importance because of its close relationship to non-communicable diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than three-quarters of non-Indigenous Australians with diabetes and more than half of Indigenous Australians with diabetes adhere to the NHMRC eye examination guidelines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All NCD risk factors are markedly high among the urban slum adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors, and this ability may provide a unique mechanism by which mindfulness meditation reduces distress.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide preliminary support that rosiglitazone may offer a novel strategy for the treatment of cognitive decline associated with AD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypergastrinemia was not  present after SG, but a tendency of enhanced gastrin secretion was observed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This simple, cheap, and well-tolerated treatment should be added as an adjunct to the postoperative care of gynecologic oncology patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that DPP-4i use did not increase the risk of HF compared with sulfonylurea.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The total CBI-BA and the FACT-BA scales have adequate internal consistency reliability estimates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have implications for further investigation of using idazoxan as a probe to develop potential novel medications to treat alcoholic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results support efficacy of the enhanced emergency department intervention for improving linkage to outpatient mental health treatment but underscore the need for improved community outpatient treatment to prevent suicide, suicide attempts, and poor clinical and functioning outcomes for suicidal youths treated in emergency departments.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnancy does not lead to immediate or medium-term adverse effects  for CF patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adiposity indicators and age play an important role in the prevalence of  overweight and obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was the first study to quantify UI levels in Cyprus.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This method allows analysis of a large number of samples per day, which is ideal for use in epidemiologic studies and may enable estimation of polyphenol consumption and determination of their possible role in preventing of certain pathologies, such as cancer, cardiovascular and degenerative diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although lower plasma arginine concentration at time of admission was associated with PU development, the AUC for arginine was not significantly different from 0.50.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Imaging can be difficult and treatment options are limited.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Risks of CVD events and mortality increased exponentially with eGFR  drop, while UACR showed positive predictive linear relationships, and the risks started even in high-normal albuminuria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In its turn, Cope could be offered when targeting broader outcomes, such as symptom improvement, rather than clinical caseness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PEM is inferior to PC for accurate monitoring of drug nonadherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, co-administration of food with these anti-malarials by populations consuming a typical Western diet should be avoided to reduce the risk of toxic side effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In women with DFM, increased body size is associated with worse pregnancy outcome, including stillbirth.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients in which atrial fibrillation was diagnosed prior to the index stroke, about 23% received anticoagulation according to guideline recommendations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study yields a scale that can be used to assess reasons for limiting drinking among HIV-positive drinkers and provides information that can be used to enhance interventions with this population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An early nutritional intervention with a supplemented MedDiet reduces the incidence of GDM and improves several maternal and neonatal outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings re-emphasize the need for early ticagrelor administration in primary PCI treated STEMI patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prevention of delirium symptoms requires its reduction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides preliminary findings that this therapeutic video game targeting cognitive control deficits may be an efficacious LLD intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be proposed as an effective alternative to conventional surgical procedures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Invasion of the seminal vesicles (T3b) occurs most often along the ejaculatory duct complex with low MR sensitivity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the findings of this analysis, patients requiring preoperative angioembolization and having a BMI >30 have a significant increase in their risk of postoperative infection, particularly if associated with leukocytosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings may be useful for screening women at risk of relapse and targeting interventions to key variables.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Monitoring  of environmental metal levels and further studies are urgently needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "\\xa0Patients undergoing bariatric surgery were more likely to have fractures than were obese or non-obese controls, and this risk remained higher after surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was support for the hypothesized model of the prevention of physical aggression during early childhood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at clinicaltrials.gov  as NCT01455636.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women who reported being dissatisfied with their body image due to having low weight or overweight had worse quality of life in comparison to those who were satisfied (with their body weight).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, we conclude that these two methods of A1C testing should not be used interchangeably.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Scrotoscope provides a clear field of vision and makes tissues harvested available for pathologic examination when performing decortications of EC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The theoretical basis of the intervention design can serve as a reference for nursing education and the design of health education programs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with pre-neoadjuvant therapy proven axillary disease may be a candidate for SLNB as opposed to planned ALND with good multidisciplinary review  of their response and localization of previously positive lymph nodes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings indicate that clinical care and programs aimed at improving birth outcomes will have the greatest impact if they address maternal nutrition both before and during pregnancy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These biochemical cardiovascular risk factors may identify women who will benefit from  primary prevention of cardiovascular disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estimates of intracluster correlation for maternal mortality need to be treated with caution and a range of estimates should be used in planning future trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The new model developed exhibited adequate validation characteristics supporting the clinical use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TZP-101 substantially reduced the frequency and severity of nausea and vomiting as well as overall gastroparesis symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intercostal nerve blockade is an easy, safe, and inexpensive method that can be used to optimize pain control after PCNL.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings in the current study indicate that it is likely that the practice of a program based on the Feldenkrais method can contribute greatly to the QoL of patients with PD, suggesting the importance of interventions that promote wellness for this population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the results suggest that the effects of diets are likely to be habitat specific, and  observations from the gut microbiome are not transferrable to the oral microbiome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical corticosteroids and antibiotics result in restoration of skin barrier integrity and decreased secondary infection.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adherence to mammography is unsatisfactory in Boa Vista, Roraima, and has a predominantly opportunistic character.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data show that carry on the control activities of production of gluten free meal in school canteens would be appropriate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both the simulation study and the analysis of the Nursess Health Study, a case-control study of type 2 diabetes data with high dimensional SNP measurements, demonstrate the advantage of the network based approach over the competing alternatives.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Insulin resistance seems to exist in individuals with both migraine and prediabetes, and there is a possible negative association between DM and migraine.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Peer-support groups using a problem-based method could be a useful and comparatively inexpensive tool in alleviating work-related stress and burnout.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings highlight the importance of maximising the contrast of objects in the environment, and may help explain why older adults wearing multifocal spectacle corrections exhibit an increased risk of falling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the association in the first-trimester and postpartum period should be validated by further research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cite this article: Bone Joint J 2017;99-B(1 Supple A):31-6.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of a HIDA scan in the diagnostic workup significantly improves sensitivity and can add valuable information in the appropriate clinical setting.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Drugs acting as ligands to the PPAR-\\xce\\xb3 may be potential up-stream therapies for AF prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the basis of a systematic review of studies that were judged to be of high or medium quality, there is an indication that some nutritional factors seem to be associated with an increased fracture risk among children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sldenafil may be a promising treatment for metabolic disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High initial levels of self-efficacy may be characteristic of Web-health users interested in online interventions and may alter the function of SCT in these programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum ferritin is a significant predictor of 10-year hard CHD risk for HANDLS study participants, a low-income, urban population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CITB relieved pain, facilitated ease of care and improved mental health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SPLC is superior to MPLC in terms of short-term cosmetic outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relationships with local and locoregional recurrences were also present in women treated with mastectomy, indicating that they are not merely explained by density masking residual disease in women treated with breast-conserving surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, the high mortality due to violence is a warning sign.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continued education and policy changes are required to support practitioners in opportunities to enhance pregnancy planning.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This reality suggests the need to change the local prevention campaigns for spinal cord injury in the elderly.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Resilon can be used for retreatment, but it still allowed microleakage.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may have important implications for understanding negative alcohol-related behaviours and promote the consideration of social context, social pressure and social cognitive abilities in the development of public policy and targeted interventions to prevent alcohol-related antisocial behaviours.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this real-world retrospective analysis, switching high-risk statin-treated patients from omega-3-acid ethyl esters to icosapent ethyl resulted in favorable lipid changes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of malnutrition is high among geriatric outpatients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that youths have trajectories to homelessness and service needs that are distinct from adults and may guide future planning for this vulnerable population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physical activity is also associated with favorable HDL-C.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Idiopathic pulmonary fibrosis was found to be the most common interstitial lung disease subtype followed by non-specific interstitial pneumonia, sarcoidosis and connective tissue disease-related-interstitial lung disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of its relatively low cost, high availability, and ease of use, exercise training is an intervention that could be accessible to most patients with heart failure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Identifying new technologies effective and acceptable to patients is an option to improve adherence to diabetes care.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Impaired mtDNA replication causes early and progressive depletion of mtDNA in the RV of the patients with congenital heart disease during the transition from hypertrophy to failure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some symptoms were refractory regardless of management strategy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Without adjustments for casemix, a large number of providers are misclassified regarding to cost performance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further large-scale, prospective investigations are necessary for clarification.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, this study provides support for the concept that the individual effective FSH starting dose for gonadotropin induction of ovulation in anovulatory infertile patients can be predicted on the basis of initial screening characteristics, such as body mass index, clomiphene resistance or failure, free IGF-I and FSH.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This group may also require more intensive cessation interventions targeting self-efficacy to improve cessation rates.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chlorpromazine can be used as an intracavernous vasoactive agent; it is similar to phentolamine in efficacy and short-term side effect profile.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Striatal abnormalities occur in schizophrenia patients and unaffected siblings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypertension is an important risk factor for cardiovascular and all cause mortality even in the obese.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given its low cost and greater convenience, aspirin may be considered a reasonable alternative for extended thromboprophylaxis after THA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This regimen can be considered as an alternative therapeutic approach for a subgroup of COPD patients and may help to improve patient compliance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The disconnection technique could be helpful to accelerate lung collapse with a BB.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Working mothers may need additional resources in this setting to enable them to practice EBF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Available data do not allow conclusions on the comparative efficacy of different surgical techniques; the choice of the surgical technique for a single patient remains an open question, and it is likely that the degree of prevention of CV diseases depends, among other factors, on the baseline conditions of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This meta-analysis indicates that T2DM risk as whole was strongly associated with elevated levels of inflammatory cytokines (IL-1\u221a\u00e9\u00ac\u2264, IL-6, IL-18, CRP), TNF-\u221a\u00e9\u00ac\u00b1 and low levels of adiponectin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings also have implications for required sample sizes for future HIV prevention trials where seroconversion is the main outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To sustain PST's effect, an intervention that uses a problem-solving framework to enhance rehabilitative skills may be necessary.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is recommended that future interventions among similar high-risk job groups focus on the implementation aspects of the interventions to maximise outcomes more distal from the intervention such as work ability and sickness absence.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This method is recommended to help optimize debris removal with the further possibility of instrument sterilization and reduced risk of cross-contamination.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, this model can act as a framework for designing and implementing educational interventions for the prevention of nosocomial infections.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work should examine the generalizability to a more diverse population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight gain and growth equaled that of healthy peers at 9 to 12 years but was suboptimal at 5 to 8 years and dramatically declines at 13 to 16 years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The AGE/RAGE axis may be of importance in the prevention and management of diabetes complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study clearly revealed that there is an increase in all deleterious lipid parameters and a decrease in favorable lipid measures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present analyses provide robust novel evidence for the short- and long-term benefits of lowering LDL-C for the primary prevention of cardiovascular disease among individuals with primary elevations of LDL-C \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022190 mg/dL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We did not find strong evidence for concordance between the few associations highlighted by previous GWAs of breast cancer survival and this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A single treatment of intrastricture triamcinolone injection did not reduce the time to redilatation after balloon dilatation of Crohn's ileocolonic anastomotic strictures and there was a trend toward a worse outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endoscopic NET placement can be performed at the bedside without the need for oronasal transfer, additional sedation, or fluoroscopy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For people with serious mental illness, social factors appear to influence use of smoking cessation treatment above and beyond personal factors and may be specific to the type of treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Follistatin may potentially act as a marker of or be involved in the pathophysiology of both reproductive and metabolic features of PCOS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to involve the workplace when an intervention is put in place to support RA patients in their work participation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results would aid surgeons in better patient selection and identification of patients requiring more careful follow-up.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NAFLD patients were older and had a later onset of IBD disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data demonstrates that the prevalence of sarcopenia is associated with older age, malnutrition and comorbidities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The smallest LMWC molecules (D4) appear to have the greatest capability to diffuse into the surrounding ocular tissues.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result may have implications for both acupuncture treatment and for future trial methodology.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the abuse potential of nabiximols should be no higher than that of dronabinol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings indicate a need for psychosocial support and coping strategy enhancement in people at risk of psychosis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Offering an online education option for WIC participants could broaden the reach of nutrition education and lead to long-term positive dietary changes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus patients who chewed gum inadvertently prior to procedure should not be denied or delayed administration of sedative and anesthetic medications.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, educational resources such as this will be beneficial to help support women given the current resource and time implications of the year on year rises in the incidence of gestational diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed that metabolic syndrome was present in almost one third of study population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present finding from Oman supports the view of other studies that there are low serum levels of DHA among children with ASD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Familial aggregation of the disorder was demonstrated, the first Cuban epidemiological evidence of genetic and enviromental contributions to pre-eclampsia risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, older age was consistently associated with poorer standing balance, both in single and in dual task conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bariatric surgery induced the disappearance of NASH from nearly 85%  of patients and reduced the pathologic features of the disease after 1 year of follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our data support the use of myocardial salvage as an end point for clinical trials investigating novel reperfusion strategies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found a high prevalence of periodontitis in Thai patients with RA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, this technique may be used in future regularly to treat chronic anal fissure for prevention of this morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women and individuals who were older, overweight and performing heavy work had a higher risk of CJS in this adult population residing in Vi\u221a\u00c9\u00ac\u00dfosa, MG, Brazil.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The used drugs' combination and volume could be recommended as a routine preemptive analgesic policy for children assigned for adenotonsillectomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Responsible practice suggests that treatment targets and the current means to achieve them should both be examined.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, future intervention studies may need to search for more effective intervention strategies targeting parental regulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates, for the first time, an in vivo impairment in GABA transmission in schizophrenia, most prominent in antipsychotic-naive individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that the polymorphism of metalloproteinases-1 might have a role in mediating susceptibility to pelvic organ prolapse.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although SPLC takes longer than MPLC, experienced laparoscopic surgeons can perform SPLC safely with results comparable with those for MPLC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with body mass index >40\\xa0kg/m2 have greater than twice the risk for complications with odds ratios increasing with increasing body mass index class.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study highlighted the importance of using SHC records with oncology patients to improve nursing practice related to sexuality issues.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endurance-training can be a helpful adjunct treatment for hospitalized patients with severe affective disorders in the initial stages of pharmacotherapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Normal humans have limited reflex capabilities to sustain simultaneous reductions in oxygen and pressure, and may experience hemodynamic instability episodes in such condition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of request for Autopsy at the University of Uyo Teaching Hospital during the period of this study was low, similar to other previous reports.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The socioeconomic status was associated with the psychological outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Concomitantly administered medications (lorazepam, morphine-scopolamine, clonidine, or propofol) do not appear to have any clinically important effects on distribution-phase sufentanil pharmacokinetics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caffeine contributes to SIF.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional efforts to prevent potential downstream mediators through which delirium increases mortality may help to improve outcomes among hospitalized older adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Circulating concentrations of SHBG represent a  potentially useful new biomarker for prediction of risk of GDM beyond the currently established clinical and demographic risk factors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trained patients are as effective in imparting knowledge to their peers as specialist health professionals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While multiplex platforms can provide quantitative information on a large number of serum analytes, results should be cautiously compared across platforms due to their intrinsic features.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Immediate clamping of the umbilical cord should be discouraged.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinically, our findings offer important insights for clinicians when planning AOT interventions to reduce UL movement acceleration and improve UL function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no evidence of a favourable atherosclerotic profile from stable moderate drinking compared to stable non-drinking.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative PTH and its decline level were significantly correlated with postoperative serum calcium concentration but had a low accuracy for predicting symptomatic hypocalcaemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Externships are beneficial because they influence the rank list of applicants and are viewed as valuable experiences.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, intravitreal steroids may be useful in DME with HEs in the fovea.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This 11-item questionnaire could inform patients at higher risk, and their clinicians, that they should take preventive steps to reduce driving mishaps, which was accomplished in aim B using DD.com.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The increased risk of developing diplopia after placement of a BGI must be taken into consideration.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study is the first to compare survival outcomes of HIPEC versus conventional therapies for recurrent US and is suggestive of treatment benefit.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regular cystitis is positively associated with UBC risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future PIRO-development is needed to straighten predisposition, infection, and especially the response category.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation Segmental kinematics method was used to estimate the displacement of the COM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deficient medical records could have implications for diagnosis and treatment of IBC and proper documentation of cases in cancer registries.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nicotine gum may be an efficacious harm-reduction alternative for smokers who are not ready to quit and may promote smoking cessation, the ultimate goal in the treatment of tobacco dependence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine\" use of sNMES to the proximal affected upper limb after acute stroke cannot be recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This review included a majority of low-level evidence studies that limit extrapolability of the results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor metabolic health, irrespective of BMI was associated with greater depressive symptoms at the start of follow-up, whereas a poorer course of depressive symptoms over time was observed only in those with both obesity and poor metabolic health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of high PCT and CRP was no more predictive of mortality than high CRP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sickle retinopathy occasionally presents with vitreoretinal complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Frailty in particular was identified as a major risk factor for malnutrition in community-dwelling elderly  persons.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neuropathy appears to be associated with the length of exposure to new AEDs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They must first determine whether a small intake of TFA from PHVO is safe and what constitutes a safe amount.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other measures such as efficiency and cost-effectiveness of the mode should also be considered when determining the most appropriate form of data collection for use in monitoring indicators of cancer detection and control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, around one-quarter of the children did not respond to this intervention and these children would appear to need more intensive or more prolonged help to improve their reading skills.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of the uncertainties concerning the safety of ICSI, couples with moderate oligozoospermia or moderate oligoasthenozoospermia need not be subjected to this procedure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longitudinal studies are needed in Switzerland to elucidate the causal relationships of these associations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Doses of 300 mg or more (in single or multiple doses) significantly reduced levels of PCSK9 and LDL cholesterol for at least 6 months.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ANTHEM-HF should provide additional and valuable information regarding the safety and the relationship between the site and intensity of ART and its salutary effects on HF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Social family support, emotional and financial difficulties should be investigated in all Moroccan breast cancer patients, especially among younger  ones, in order to detect those at risk of PD and offer them appropriate support.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the level of phthalates is relatively mild, an association of phthalate levels and reduced quality of human semen has been shown in the present study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whilst CPA is responsive to LAmB, caution should be exercised with repeated courses, if other treatments are available.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Information on the effectiveness of using a self-help book, without therapist assistance, in alleviating distress is important, as bibliotherapy can provide inexpensive treatment that is not bound by time or place.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was, however, a trend toward a protective effect in patients with uncontrolled diabetes mellitus, suggesting that such patients may benefit from perioperative antibiotic use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We revealed sex dependent differences in the distribution of tested loci which are associated with BMI in the population of Poles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary intake of cholesterol may increase the risk of active tuberculosis, whereas marine n-3 and n-6 FAs may reduce the risk of active tuberculosis in the Chinese population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implementation of the package by family doctors was feasible and improved prescribing and some lifestyle changes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rs1122608 is associated with the risk of CAD and TG level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DA has better effect of increasing DO2 than NE, but its side effect of accelerating HR may to some degree restrict its use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is important given the high prevalence of diabetes worldwide; appropriate CVD management is critical to addressing the morbidity and mortality associated with the disease.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that clinicians should screen for depression early in the course of HF management.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incident gallstones and the metabolic syndrome share common risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More prospective cohort studies of longer durations, with more sophisticated methods that examine age-varying relationships, and that control for a comprehensive set of confounders, are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Octylcyanoacrylate tissue adhesive may be offered as an option for wound closure following breast surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These factors should help determine the appropriate strategy for proposing a third line of chemotherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of etomidate for RSI in trauma patients led to chemical evidence of adrenocortical insufficiency and may have contributed to increased hospital and ICU lengths of stay and increased ventilator days.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Particular nutrients should be translated into dietary patterns which allow the individual patient to address these nutrient deficiencies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that the NRST is a promising screening tool for the prediction of malnutrition and sarcopenia in community-dwelling older Japanese people.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "e-POCT, an innovative electronic algorithm using host biomarker POCTs, including C-reactive protein and procalcitonin, has the potential to improve the clinical outcome of children with febrile illnesses while reducing antibiotic use through improved identification of children with severe infections, and better targeting of children in need of antibiotic prescription.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Levobupivacaine is a valid alternative to traditional local anesthetics for surgical removal of lower third molars.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both exenatide BID and prandial insulin lispro, each added to basal  insulin glargine, were effective at reducing HbA1c in Latin American patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LRFS of patients with locally advanced invasive breast cancer after mastectomy and axillary surgery was better with CCRT than with SCRT and with similar profiles of adverse reactions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modulation of muscular function induced by SMV may aid to explain its action on smoothness and coordination of movements.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this meta-analysis support the hypothesis that RBP4 is a modest independent risk factor for GDM (i.e., nonobese patients with GDM might express RBP4 at abnormal levels).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Together, the preclinical indicators identify a subset of high-functioning older women who are at high risk of mobility disability, and provide a potential basis for screening for disability risk and targeting interventions to prevent mobility disability.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results were limited by the low doses used and a small cohort.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this well-controlled study of NOD2 genotype and fecal microbiota, we identified no significant genotype-microbiota associations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NFB appears to be effective at reducing CIPN symptoms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physical breast  trauma, lower parity, a trend for less breast feeding had more significant associations with pre-menopausal than post-menopausal onset.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the respective advantages and disadvantages of cryoanlgesia and PCEA, both of which prove to be effective for pain management postthoracotomy, their choice must be decided according to clinical needs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diarrhea was more common with pertuzumab than with placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings from this large prospective study show that men who are taller and who have greater adiposity have an elevated risk of high-grade prostate cancer and prostate cancer death.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pelvic MTX injection via the posterior fornix is a convenient procedure associated with minimal complications and serves as a good alternative for treatment of tubal pregnancy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LEVEL OF EVIDENCE: III, prospective case-control study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As transmission levels drop in Thailand, it may be necessary to employ higher throughput and sensitivity methods for parasite detection in the phase of malaria elimination.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our observations highlight the high level of vulnerability for HIV acquisition of both poor professional \"kata\" and nonprofessional \"street vendor\" FSW categories.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pilates and walking positively impact quality of life, depression and anxiety.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "State legislators have positive attitudes toward lobbyists for non-profit health organisations and state medical societies regarding tobacco issues.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the conclusion that the oblique approach for US-guided radial artery catheterization may replace the 2 classic approaches owing to its superior success rate, higher first attempt success and shorter time consumed for catheterization with more operator satisfaction after the procedure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disease-related weight loss may be an important and heretofore unknown indicator of poor prognosis in MM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This retrospective study provides evidence to substantiate the optimum method of ceasing CPAP; the CICADA method, does not adversely affect weight gain, time to reach full feeds and may reduce time to cease caffeine in PBs <30\\xe2\\x80\\x85weeks gestation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, these findings suggest that 5-HTTLPR genotype should be a factor in determining the proper line of treatment for depression.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Appropriate nutrition education strategies should be developed for children with a history of EUGR to prevent later associated pathologies, as neonatal nutritional support and feeding during childhood are associated with an  increase in diseases in this risk group.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, BMI alone was not related to bone volume in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IBD patients often change their dietary intake in order to affect digestive tract symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In DEFINITE patients, inducibility of either VT or VF was associated with an increased likelihood of subsequent ICD therapy for VT or VF, and should be one factor considered in risk stratifying nonischemic cardiomyopathy patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Activity restriction was the strongest predictor of risk of overweight and obesity at follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The RPL patients and controls had a similar proportion of women with  elevated fructosamine considered diagnostic of diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continued validation and training will be needed in Connecticut to improve completeness of reported health care-associated infection data and to assure that publicly reported data are valid.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "iBGStar was not superior to the traditional meter.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, it appears that midazolam induces a dissociation between explicit and implicit memory in young children in the pediatric surgery setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of a mineral- and vitamin-enhanced MNP significantly reduced stunting in FT-LBW infants in this high-risk setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surveillance imaging may help early detection of deep-seated malignancies but the benefits accruing from such monitoring warrants prospective evaluation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows a lower need for plasma expanders in patients who receive only starch plasma expanders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings represent an important step forward in treating a significant unmet need in psychotic populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Stroke risk stratification in patients with AF should include renal function.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combined vitreoretinal surgery and phacoemulsification is safe and effective in treating vitreoretinal abnormalities coexisting with cataract in diabetic and nondiabetic patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We show replication of 5 Caucasian genome-wide association studies lipid associations in Mexicans.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the model that reduction in disruptive behavior can lead to improvement in activities of daily living.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, when compared to controls, fathers of children and adolescents with T1DM appear to experience CHAOS differently to mothers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clusters of risk factors relate to increased common CIMT in a graded  manner, similar in men, women and across race-ethnic groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This risk is not explained by a binge drinking pattern or addiction to alcohol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings show that patients with SCD commonly have multiple nutrient insufficiencies/deficiencies and support the growing evidence for the link between low zinc and increased VOC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We emphasise the importance of identifying reasons for dropout and undertaking an appropriate statistical analysis accounting for such dropout.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The self-monitoring behaviors of self-weigh-in, daily steps, high-intensity activity, and persistent food logging were significant predictors of weight loss during a 6-month intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, the relationships between these factors and the childs SSB intake differed for children with distinct ethnic backgrounds.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The role of vitamin A supplementation for at-risk groups is supported by this study, but needs to be clearly defined within a broader approach to health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for therapeutic trials are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we recommend the KE 3-glass test as a new standard for screening patients with signs and symptoms of chronic inflammatory prostatitis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that acupuncture may help to regulate weight owing to its beneficial effects on hormones such as insulin, leptin, ghrelin and CCK in obese subjects even after a few weeks of treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigations are necessary.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to consider both pharmacokinetics and pharmacogenetics in optimizing gemcitabine accumulation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The difference between low- and high-BMI patients trended toward significance for leg pain and ODI score at 3 months, but this difference disappeared by 12 months.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An increase in the number of vesicles was preceded by late asthmatic reactions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support early 2-dose MV to provide measles immunity for young infants without risk of interference with antibody responses to subsequent MV doses administered as part of SIAs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While this does not necessarily preclude the use of this practice it does emphasise the importance of taking appropriate remedial action to minimise the risk.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that SMSMT is effective in reducing dropout rates from a pediatric lifestyle intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre-operative malnutrition is an independent risk factor for readmission within 30 days of discharge after elective spine surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A preemptive analgesic with Parecoxib in the perioperative management after RALND of melanoma patients can be recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, acellular dermal matrix does not appear to affect the degree of capsular contracture formation in the setting of prior irradiation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, special attention should be given for  severely wasted children in the prevention and control of malaria.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The proportion of U.S. physician visits with an NOS psychiatric diagnosis increased to nearly 50% in 2007-2010.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results need further verification and the biological importance of these findings needs further investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of logistic regression analysis implied that, to improve long-term functional outcome, decompression should be performed in patients before herniation occurs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was true among nurses, and thus also for hospital ward personnel as a whole (i.e., nurses and physicians combined).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, use of metformin  may reduce mortality from other causes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study showed improve balance and gait abilities after VRGT compared with general physical therapy and were found to be effective in enhancing the functional activity of persons with stroke.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at clinicaltrials.gov (NCT00895141).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Robotically assisted ablation has the capability to deliver greater bipolar voltage attenuation compared with manual ablation with appropriate selection of RF parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some clusters seemed more atherogenic than others.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased PAI1 and Lp(a) could impair fibrinolysis and potentially increase CVD risk, although the mechanism for these effects is uncertain but does not appear related to cytokine  or insulin mediated mechanisms and requires further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Age and stage at recurrence were identified as prognostic factors for OS and PFS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AFIX consultations for adolescents need improvement to have a stronger and more durable impact, especially for HPV vaccine.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, although patients with pre-existing osteopenia are likely to require monitoring and bone-protection strategies, patients with normal BMD would not appear to require monitoring beyond the recommendation for healthy postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient education material should contain information to highlight these potential problems.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decreasing trends in nutritional status and appetite  level after SCI require special attention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that different living conditions significantly affect the PCOS phenotype.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to reduce HIV/STD incidence among adolescents in South Africa should address the risk associated with sex, unprotected sex, intimate partner violence, and multiple partnerships.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study reveals that a large proportion of patients dose bolus insulin PostP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two key challenges to the health industry arise from this evidence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, these results suggest that while milk and yogurt consumption is associated with a favourable body phenotype, the blood lipid profiles are less favourable when eaten as part of a low-fat high-carbohydrate dietary pattern.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effects may be sustained with structural interventions to reduce alcohol use in sexual contexts and support risk reduction behavior changes over the long-term.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of ongoing prospective trials should help to define the role of the RS assay in this setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research must examine who benefits most and from what components of psychosocial interventions to enable clinicians to recommend appropriate psychosocial care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further dissemination to external stakeholders such as psychiatry consultants and hospitals may be needed to influence antipsychotic prescribing for NH residents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by F. Hoffmann-La Roche/Genentech; APHINITY ClinicalTrials.gov number, NCT01358877 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study indicated that nearly half of the children under five years in the study area were stunted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(1) D2-40 monoclonal antibody is a marker of bad prognosis in CLM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings suggest that a feeding trial in participants with asthma is feasible.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Propionyl-L-carnitine 1 g/day should be investigated further as a co-treatment for mild-to-moderate ulcerative colitis (NCT-01026857).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CER-001 is well tolerated when administered to humans as single doses up to 45\\xa0mg/kg and mobilises and eliminates cholesterol via reverse lipid transport.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important for health care providers to identify patients who will require extra encouragement to seek timely medical care and to follow through with treatment recommendations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Coadministration of ezetimibe and fluvastatin was safe and well tolerated and caused significant incremental reductions in LDL-C and total cholesterol compared to fluvastatin administered alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study identified intratumoural and peritumoural LVD and the VEGF-C expression in tumour cells as more significant predictors of metastatic risk than melanoma thickness, ulceration and other clinical-pathological parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the nonorthopaedists, scores were significantly better if they had taken a medical school course or residency rotation in orthopaedics, suggesting that a rotation in orthopaedics would improve the general level of musculoskeletal knowledge.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AAT is a promising option for the treatment of agitation/aggression and depression in patients with dementia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "2016 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor nutritional status is a predictor of lower FIM improvement in geriatric stroke patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, given the post hoc design of this study, these findings need to be confirmed in additional clinical trials before firm conclusions can be drawn.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longer time and intensified efforts stressing a public health approach are needed to demonstrate the effectiveness of community mobilization in reducing substance use and HIV risk in this rural Thai community.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RSL is safe and accurate, and has comparable surgical endpoints to WL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The significantly greater changes in weight, glucose and cholesterol parameters observed in the olanzapine and olanzapine-fluoxetine combination groups should be entered into the risk-benefit assessment in determining appropriate treatment options for these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For East Asian women, overweight, late menopause, and lack of breastfeeding appear to increase risk of both luminal and ER-PR- tumors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medial collateral ligament ruptures need not be treated operatively when the anterior cruciate ligament is reconstructed in the early phase.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings confirm that  the illness burden of BED extends to high medication utilization and underscore the importance of thorough medication reviews when treating individuals with BED.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using LNF to treat the low neck did not increase the risk of regional failure \"in early T and early N diseases\" or decrease PEG tube requirements.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risk can be amplified by high household chores load.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Hispanic/Latino population, dulaglutide efficacy and safety was consistent with that of the overall population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further assessment could delineate relationship between serum lipid levels and depression with suicidality in other ethnic groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings support the reliability of the PCQ-R and the conceptualization of control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The status of risk factors for lung cancer among residents in Chengdu was not optimistic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre-existing diabetes was associated with a higher risk of death following CAP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Each macular retinal layer and CMT had a tendency to increase for one year after 577-nm PASCAL photocoagulation, whereas the average thickness of retinal pigment epithelium decreased at one-year follow-up compared to the baseline.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The early onset of peripheral neuropathy might be a robust predictor for TTF in patients with metastatic breast cancer treated with paclitaxel.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Almost three out of ten BC patients have at least one hereditary risk cancer feature that would warrant further genetic counseling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These positive outcomes suggest that clinicians should consider integrating this approach into clinical practice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The specific measurement of candidate barriers such as microbial pathogens, wound inflammatory state, and fibroblast function should be considered in future randomized trials to improve our understanding of the basis for chronicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subcutaneous C2 nerve field stimulation seems to offer a safe and effective treatment option for selected medically intractable patients with fibromyalgia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multiple obesity indexes, possibly including the waist/stature ratio, should be considered when investigating the association between body composition and CTS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, HDL-C levels in the phlegm turbidity group were lower than those of the non-phlegm group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrasonography-assisted CAS is feasible and safe.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Meniscal and articular cartilage lesions were more frequent and more severe with recurrent laxity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the frequency of intubation and/or paralysis following brain injury in this sample, estimating GCS or exploring other means to gauge injury severity is beneficial, particularly because a portion likely did not sustain severe brain injury.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It provides  both diagnostic and therapeutic value preoperatively and its use should be advocated.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings call for more aggressive screening and intervention of microalbuminuria in diabetic patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals with high plasma concentrations of methionine, choline,  and betaine may be at reduced risk of CRC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reallocating time from ST and LPA to MVPA in children is advocated in school, home, and community settings.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cost savings is related, in part, to reduced length of stay with laparoscopic surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "we noted that parecoxib with PCA morphine can be used for post-cesarean delivery analgesia with the same efficacy as ketorolac for an opioid-sparing effect.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Albumin perfusion plus phototherapy appears to induce a rapid and early decrease in unconjugated, unbound bilirubin, the fraction that is potentially neurotoxic, while phototherapy alone acts over a longer period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first study reporting that beneficial effects on adiposity and CVD risk factors of a physical activity centred intervention are sustained 2 years after the cessation of training in obese children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taking into consideration all the obtained results and recommended fat concentrations in a daily ruminant ration, we recommend supplementing a dairy ewe's diet with 30 g kg(-1) DM of CSC cake in practice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest that drinking, and perhaps wine-drinking in particular, is associated with lower mortality even in old age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions aimed at weight control should also try to maintain or improve nutritional status.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The nutrition education intervention led to improvements in childrens dietary diversity and nutrition knowledge of the caregivers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was a statistically significant difference between the sets with the central and peripheral vestibular syndrome in the frequency of occurrence of hypertension, impaired hearing, otitis media, in mild obesity categorization and in balance disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, TmLRP-TT can be an available option for BPH patients, especially older, high-risk patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C-reactive protein was as useful as procalcitonin in reducing antibiotic use in a predominantly medical population of septic patients, causing no apparent harm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Explanatory mechanisms for this association between poorer developmental function and older age need to be identified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It positively impacts resilience, QoL, ALI, and emotional distress.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results indicate that there is a significant difference in REE between Caucasian and African-American overweight women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lack of reliable transportation was reported as a significant barrier to accessing care during pregnancy, delivery, and postpartum by women in Bangladesh and Burkina Faso.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence that equal, if not more attention should be dedicated to CRF improvement relative to fat-loss for favorable pancreatic BCF and thus possible reduction in CV risk in individuals with MetS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study indicated that CPFA could be superior to HVHF in improving the clinical manifestations and eliminating inflammatory mediators, which had implications in the optimal treatment of septic patients with MODS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is some difficulty with the assessment of fibrosis and cosmetic outcomes, especially in patients with small breasts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data add to our knowledge of the pathophysiologic and genetic basis for recurrent stroke risk and may have implications for clinical care decision making.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low doses of E(2) (1 mg and lower) can be considered for the prevention of osteoporosis, while titrating the hormone dose to individual patient's needs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combined treatment of warm needling therapy and auricular acupuncture or simple warm needling therapy present the effects of weight reducing and lipid reducing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prescriptions for rivaroxaban were not optimal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the lack of benefits and the costs this procedure adds to TKA, its routine use cannot be justified during primary TKA for osteoarthritis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Not meeting relative MVPA and VPA recommendation was associated with significantly higher likelihood for presence of MetS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support use of fasting TGc instead of postprandial TG responses for cardiovascular risk stratification in clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results have to be translated with consideration of limitation of population-based studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MNA is a well-developed questionnaire which evaluates malnutrition in COPD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HIV infection contributed to decreased TC, LDL-C and HDL-C.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the higher ORR and Ki67 reduction in the ER+, HER2+ subgroup indicates a potential role for PI3K-targeted therapy in this setting\\xa0and may warrant further  investigation with better-tolerated second-generation PI3K inhibitors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To ensure their uptake, CQI programs must acknowledge local clinical guidelines, be compatible with translation into clinical activity and have managerial support.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Duodenal switch is also associated with a higher morbidity rate than gastric bypass.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BAE is a highly successful procedure in treating haemoptysis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study showed that supplementation with vitamin C (2 g) po decreased morphine consumption in the postoperative period in patients undergoing laparoscopic cholecystectomy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it is worthwhile to assess the long term effects of rising TSH levels  and inadequate iodine nutrition during pregnancy on the offspring to prevent even mild iodine deficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results indicate that oocyte vitrification procedure followed by ICSI is not inferior to fresh insemination procedure, with regard to fertilization and embryo developmental rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Length of residence (\u221a\u00a2\u201a\u00c4\u221e\u00ac\u202215\\xa0years) was positively associated with prevalence of overweight, among adult immigrant population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this multicenter, prospective analysis, the authors found no significant acellular dermal matrix effects on complications, time to exchange, or patient-reported outcome in immediate expander/implant breast reconstruction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Infusion of large amounts of albumin should be cautiously administered in the sickest cirrhotic patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Problem-solving breast MRI for inconclusive mammographic findings helps identify malignancies with high sensitivity and a high negative predictive  value.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Residual pain may be due to the lack of sensory block in dermatome L1, suggesting that modification of this technique should be considered for this type of surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment regimens and responses in this cohort varied considerably.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, long-term primary research is needed to address uncertainty associated with estimates of cost-effectiveness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Erlotinib plus bevacizumab and panitumumab is an efficient second-line treatment option for patients with NSCLC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Newly diagnosed schizophrenia patients were more prone to insulin resistance in our study population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, it is unlikely that targeting hemoglobin in the normal range for CKD patients is of benefit.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combining DTI to identify the invasive region with perfusion and spectroscopy, we can identify changes in invasive regions not seen in noninvasive regions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although both are characterized by increased intestinally derived lipoprotein particles, HDL is reduced only in SCH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-risk patients should receive special clinical attention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results, which are supported by mechanistic plausibility, suggest that vitamin D may contribute to the prevention of tobacco-induced cancers in smokers and deserve additional investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Negative MRI results may cause a low compliance rate for recommended follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fluid filled Foley catheter seems to be superior to 25 \\xce\\xbcg vaginal misoprostol regimen, when used to induce labor in primigravidae with post-term gestations with the advantage of having a shorter induction delivery interval, but more need for oxytocin augmentation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high cost of revision surgery highlights the importance of appropriate indications to avoid the need for subsequent procedures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both remain vulnerable and require greater nutritional targeting.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study hyperarousal correlated significantly with suicidal ideation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is an effective drug for the prevention and treatment to menopausal syndrome and osteoporosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although conventional echocardiography revealed no difference between patients with type 1 DM and healthy children, TDE showed dysfunctions of  both ventricles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov: NCT01722500.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further categorization of PHN patients may be helpful so that additional or alternative therapy may be prescribed to non-responders.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no difference in MHRs between study and control groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study does not support the use of Phyllanthus niruri for the treatment of chronic hepatitis B.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A limited number of participants had adequate folate intakes, whereas vitamin B12 intakes were adequate for practically the entire population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study supports that residue should be considered a primary measurement of swallowing function and be a target for identification, treatment, and evaluation of swallowing.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survival of responding patients seems to be better compared to non-responders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consequently, an effectiveness RCT is warranted, with some modifications to the intervention to include greater tailoring and more appropriate PROMs selected.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, these fatty acids may able to decrease serum hs-CRP and LDL cholesterol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Where observed, adverse events were not serious, and there was no evidence of a dose-relationship to frequency of adverse events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Well-tolerated vaccines are needed that induce immunity after a single dose for use in young children during influenza pandemics.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prescribing micronutrient-fortified SQ-LNS to ill children presenting for primary care in rural Gambia had a very small effect on linear growth and did not reduce morbidity compared to unfortified SQ-LNS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this randomised trial, adjuvant treatment using tamoxifen for 2 years reduced the incidence of contralateral breast cancer by 50% in all premenopausal women, and by 90% in women <40 years of age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The BMI-matched analysis suggests that fear of surgery is a relevant factor in why obese patients do not decide to undergo bariatric surgery lightly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MPR is a secondary adherence measure based on refill frequency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decline in mortality due to NCDs confirms that improvements in disease control have been achieved in Brazil.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study findings in relation to obesity and the prevalence of multiple risk factors for CVD are a particular cause of concern and shed considerable light on the current excess burden of CVD among farmers in Ireland.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Slow Stroke Massage can be used effectively and safely as a complimentary therapeutic strategy in depressed patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings suggest that Ia-afferent input may not substantially contribute to maximal voluntary dynamic muscle strength of the plantar flexor muscles, as tested here, and thus, the results do not support the notion that Ia-afferent excitation would contribute differently to neural activation in maximal voluntary lengthening and shortening muscle actions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This time-varying effect violated the Cox proportionality assumption, indicating that feeding trials in similar populations should extend beyond 7 d and use time-varying statistical methods.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "But serum TTR was significantly different by the severity of the patient and independently associated with mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative nutritional support should be introduced for nonmalnourished patients as it helps to maintain proper nutritional status and reduce number and severity of postoperative complications compared with patients  without such support.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that obesity and possibly alcohol overuse are independent risk factors for the development of infection following surgery for a fracture of the ankle.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the need for further investigations of cholinergic mechanisms underlying tardive dyskinesia and extrapyramidal effects of cholinesterase inhibitors when used in combination with antipsychotics in susceptible patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our model of just-in-time assessment and reinforcement of training prevents skill decay and has implications for healthcare skills training in general.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combined use of BMP-2 and L-PRF leads to the early resolution of MRONJ; thus patients who need to continue antiresorptive therapy may benefit from the combined regimen.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, total clinical symptom score and nausea were reduced during 8 weeks of treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ED90 of carbetocin at CD for labour arrest, as determined in our study, should be interpreted with caution since it may be underestimated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The efficiency and sensitivity of SLNB can be improved by combining  ICG with blue dye.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings may have important implications for predicting treatment outcomes in patients treated with trastuzumab in the adjuvant setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rs7044343 polymorphism could be involved in regulating the production of IL-33.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: EudraCT 2011-000439-10.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results confirm the relationship between variations in PON1 activities and lipid metabolism, and showed that genetically programmed low PON1  activities would have certain responsibility in the increase in glycemia and concomitantly the aggravation of atherosclerotic disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improving labor and delivery management at each level of the health system and communication between health care facilities should be a priority to reduce uterine rupture.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutrition education should be part of programs in food insecure settings aiming at ameliorating food insecurity among communities.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cholesterol level goals were achieved by many patients using the recommended simvastatin 40 mg/day, but by fewer patients among those using the more commonly prescribed simvastatin 20 mg/day.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relationships between TE doses and serum TE concentrations vary for each TE and underlying clinical conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This evidence supports that in this particular population, there is no purpose to restrict these women from using antiperspirants during their treatment, and the decision to use an antiperspirant or not in this setting should be left to the discretion of the patient.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The doses of local anesthetics and opioids used in both analgesic techniques and the complementary doses, equal in both groups, neither had any significant adverse effect nor affected newborn vitality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We demonstrate that obesity is a risk factor for developing severe AP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We propose that integrated cardiopulmonary sonography may be a useful bedside tool for treatment of ICU patients with acute pulmonary edema.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transgender individuals have suboptimal HIV and syphilis testing rates in China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Opipramol may be used as a premedication in the evening prior to surgery if the primary target is an impact on the experienced quality of sleep.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, FBT may need to be adapted for families with parents who have a high level of psychopathology.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The DC pulse produced by HANS may be a non-pharmacological alternative to labor pain with fewer side effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with HIV, pitavastatin 4\\u200amg/dl lowered both RLP-C and established apolipoprotein and lipid risk ratios more so than pravastatin 40\\u200amg/dl.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relatively high prevalence of central obesity in African-Surinamese women may underlie their higher prevalence of the metabolic syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mean change scores of a stroke group on the WMFT time and WMFT FAS should achieve 1.5 to 2 seconds and 0.2 to 0.4 points to be regarded as clinically important changes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Youth interventions integrated within intensive, community-wide risk reduction programmes may be more successful and should be evaluated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chlorhexidine-based solutions should be considered as a replacement for povidone-iodine (including alcohol-based) formulations in efforts to prevent catheter-related infection.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More attention to value in breast cancer care is warranted.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the recent focus on long-term outcomes and immunosuppression withdrawal in these  children, longitudinal studies are warranted to investigate whether IGT is reversible with calcineurin inhibitor minimization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation The findings that balance VRT in addition to CRM improves dynamic balance in elderly people with BPPV should be useful in guiding rehabilitation professionals' clinical decision making to design interventions for seniors suffering from BPPV; Improvements in tests of dynamic balance suggest that the risk of adverse consequences of BPPV in the elderly such as falls and fractures can be potentially reduced through implementation of CRM in conjunction with balance VRT; Lack of additional improvement in Visual Analogue Scale of dizziness and Dizziness Handicap Index suggests that addition of balance VRT does not influence dizziness symptomatology, per se, and CRM alone is effective to ameliorate vertiginous symptoms and potentially improve quality of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ophthalmic Surg Lasers Imaging Retina.2017;48:378-384..", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deterioration of the nutritional status coincided with a reduction in the consumption of all food groups except for ready meals and milk/dairy products whose consumption increased.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the literature associating mobility limitations with disability, morbidity, and mortality, these results are important for understanding the antecedents to poor mobility function that well-designed interventions to improve cognitive performance can attenuate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HbA1c-CV improves 3-year prediction of new-onset albuminuria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvements in dietary diversity, adequate use of iodised salt and community food security are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More high-quality longitudinal observational or intervention studies are needed on the subject.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The real prognostic impact of the surgical margin must not be overestimated.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, training for tasks in which forces play an important role (e.g., stretching, grasping) should be done using systems with natural force feedback, whereas eye-hand coordination can be trained without force feedback.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Integrated interventions also provide opportunities for adjunctive components focussing on other issues and coping strategies (e.g., to offset negative affective states), potentially tailored to the characteristics and needs of individual participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adoption of more consistent standards for methodological quality in this field, with greater attention to potential adverse events, is needed before computer-assisted therapies are widely disseminated or marketed as evidence based.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, clinical use of RDN for treatment of resistant hypertension should await positive results from double-blinded, SHAM-controlled trials with multipolar ablation catheters or novel denervation techniques.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first double-blind controlled study on AC in RA of the hand that objectively and specifically assesses positive effects supporting its integration in rheumatology.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Axial length measurements with the new SS-OCT biometer were comparable to the PCI and OLCR measurements with a higher AL acquisition rate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Advances in knowledge: (1) This study describes specific features of ILC on DBT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the same cytological material can be used for the detection of HPV DNA by specific PCR.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improving use of preconception care among publicly insured women with diabetes is critical to reducing disparities in outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reconstruction of defects, especially in patients presenting with higher tumor stages, is not associated with shorter overall survival rates, as revealed in this study, and should be considered when functional deficits due to tumor ablation can be expected postoperatively.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results indicate that patients discharged from inpatient wards at times of high inpatient bed occupancy experience an increased risk of unplanned readmission within 30 days of discharge.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistency in the type and quality of treatment offered to patients by the same clinical teams may have been responsible for the equitable survival outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight loss, satiety and adverse symptoms demonstrated only slight changes between 3 and 8\\xa0years post-operatively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings add to the available evidence that obesity might specifically be associated with the onset of multiple episodes of major depression (MDD-R).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BCS who adopted several healthy behaviors simultaneously had better HRQOL than one healthy behavior alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "En bloc pelvic resection, as a part of surgical cytoreduction, seems to be a safe and effective procedure in many patients with advanced ovarian cancer if required.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prepregnancy obesity and excessive weight gain from prepregnancy to postpartum increase postpartum diabetes and prediabetes risks among GDM women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results provide some support for the utility of plyometrics as an intervention to correct altered neuromotor control in those triathletes in which it is aberrant.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baseline and serial changes in ECG-LVH predict cardiovascular morbidity and mortality in RH patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with AUS-detected metastases had a higher axillary tumour burden than those with SNB-detected metastases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Altering intrapulmonary deposition through aerosol particle size can appreciably enhance inhaled drug therapy and may have implications for developing future inhaled treatments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Culturally acceptable interventions to better support people who perceive MS as an assault on identity should be developed to help them achieve normalisation and enhance self-identity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biweekly docetaxel therapy might be considered as an option for elderly patients exhibiting a compromised general condition.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BMI, as a continuous variable, can serve as a predictor of primary nonfunction and early graft loss after adjustment for age, race, sex, and diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for dissemination are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A new population trial targeting more intensive prevention to distressed parents with toddler behaviour problems is now under way, aiming to prevent externalising and internalising problems before school entry.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some services achieved high rates of 3-yearly testing of Indigenous  Australians for diabetes, but recommended rates of annual testing were rarely attained.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children residing in neighborhoods high in incivilities are more likely to walk to school, in spite of lower levels of perceived safety.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metformin use does not increase the risk of RAAA among individuals with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The fast-track program reduces the rate of postoperative complications and length of hospital stay and should be considered as standard care.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implant-only  procedures that incorporated ADM use had similar complication rates to those that did not.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the hypothesis that exercise promotes cortical resilience, specifically in relation to the brain regions that support inhibitory control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anti-TNF treatment demonstrated a favourable long-term effect on anti-PC levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data support the hypothesis that hyperlipidemia may play a relatively protective role in cerebral small-vessel disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When measuring  serum lipid tests in early childhood, fasting makes a very small difference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for health behavior theories and behavior change interventions are outlined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two-component principal and secondary strain analysis can be related to left ventricular myofiber geometry and may simplify the assessment of 3D left ventricular deformation by circumventing the need to assess multiple shortening and shear strain components.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetes mellitus is an independent predictor of OC among those with salivary gland dysfunction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reverse breech extractions is an attractive and safe alternative to the standard method for intraoperative disengagement of a deeply impacted fetal head in order to reduce maternal and fetal morbidly.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Three-year EFS data following H SC and H IV treatment are consistent with those reported by previous trials for H in the adjuvant setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support that individuals should be encouraged to follow a Mediterranean dietary pattern for reduction of MetS risk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may not be necessary to provide postoperative antibiotics in patients undergoing dental implant placement, however, these preliminary findings need to be confirmed by large multicentre clinical trials.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We demonstrated that patients' coping strategies and prognostic understanding were associated with FC depression and anxiety symptoms, underscoring the importance of targeting these risk factors when seeking to address the psychological distress experienced by FCs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In UK adults better home food preparation skills and more frequent use of these skills tended to be cross-sectionally associated with lower UPF consumption.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fibroadenomas and phyllodes tumours differ with regard to various cytological features, aiding in their distinction on fine-needle aspiration biopsy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In view of the lower irritation potential observed in this study, along with its demonstrated efficacy, adapalene gel 0.1% in combination with antimicrobial agents may be used as part of an aggressive treatment regimen for the management of acne.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wider implementation of the e-learning programme to improve the first step in the detection of child abuse is recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the gut may mediate vitamin D effects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Barriers to expanding APPE availability include: introductory pharmacy practice experience (IPPE) and APPE expansion, growth of new and existing pharmacy programs, financial instability of acute care facilities, and lack of preceptor development resources.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some studies that have assessed the impact of monitoring guidelines on clinical practice show only limited impact.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When pleural disease is suspected, contrast infusion protocols should be modified to achieve the best results and clinicians should be encouraged to specifically request a \"pleural CT\".", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Loneliness is associated with poorer physical and mental health and unhealthy lifestyle, modified by age, but not by sex.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is crucial that individuals report quantity and frequency of V/S use when providing medical or diet histories to health care providers.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nurses working in breast cancer care must address the decision-making process of patients diagnosed with breast cancer, including the choice to undergo breast reconstruction after mastectomy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide further evidence that EZH2 expression in the normal breast epithelium is independently associated with breast cancer risk and  might be used to assist in risk stratification for women with benign breast biopsies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metformin might therefore be used as an adjunct to lifestyle modification in women with PCOS, but not as a substitute for it.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reimbursement status, the ratio of cost to clinical outcomes and data on the long-term safety have a deciding impact on how a drug is used.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most subjects required cataract extraction, and a significant proportion required intraocular pressure-lowering surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The measurement of pleural cholesterol and LDH permits the separation of pleural exudates from transudates with an accuracy similar to the original report of Light et al, with the advantage of requiring only two laboratory determinations and no simultaneous blood sample.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A combined HDR boost and hypofractionated EBRT regimen offers a well-tolerated method of dose escalation with acceptable levels of patient-reported toxicity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results are limited by the 32% response rate and potential for bias towards selection of those most careful with their health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Repeat injections and frequent examination might be required for continued improvement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with exenatide BID resulted in stable weight but more gastrointestinal  adverse events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, judging by the effect size, our data cannot exclude that a favorable effect of high intake of fruit and vegetables could in part be driven by high vitamin C concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for voice rehabilitation including appropriate patient selection is highlighted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This procedure may serve as an alternative approach that allows a smaller incision.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest similar mechanisms in pediatric/adolescent populations as in adults for the development of sleep-disordered breathing and sleep apnea that will need to be confirmed in randomized clinical trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implementation of MAPS should be strongly considered where resources are available.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a need for coaching approaches that facilitate aerobic exercise after ending a supervised program.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This mixed-methods study showed that even though the Chinese nurses have moderately high sensitivity to the ethical issues encountered in hospitals, there is still room for improvement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results provide support for the efficacy of group-based physical activity programs informed by SCT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients must be monitored for adverse events associated with bicalutamide.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results underscore the very long-term need for support including individually tailored reevaluations and carefully monitored intervention programs adapted to family needs and severity of child disorder.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike previous studies, our data do not support an association of HbA1c with arterial hypertension that is statistically independent of age and body mass index.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, further studies are needed to explore which indicator of body fat could be used as the best marker to indirectly reflect cardiometabolic risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This SDD regimen could be a suitable decolonization therapy for selected patients colonized with CRKP, such as transplant recipients or immunocompromised patients pending chemotherapy and patients who require major intestinal or oropharyngeal surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, there may be a need to individualize counseling and interventions for these individuals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If M relaxant is necessary, cisatracurium is used.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Extracorporeal shockwave therapy is a possible alternative to surgical excision for Morton's neuroma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-\u221a\u00e9\u00ac\u00b1 methylation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among Chinese individuals with MetS, the utility of the non-HDL-C/HDL-C ratio was found to be greater among women than among men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MI can be recommended in clinical practice for screening IR in NAFLD patients for further in-depth examination.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combination of three GST genotypes association exhibiting gene-gene interaction further substantiates the increased risk of bladder cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, all staff of the department concerned should approve of the intervention and consider it as part of standard clinical routine if successful implementation is to be obtained.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports the recommendation for its implementation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrates that this bedside technology may be helpful in identifying HF and its phenotypes, especially when echocardiography is not immediately available.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We attribute this to the use of conformal techniques and daily image guidance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The newly developed SPCIT program drastically improves knowledge, attitudes and perceived skills of general surgery residents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The LG method of equine rectal examination instruction resulted in improved learning for identification of several key abdominal organs compared with SI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high rate of repeated infections indicates the need for interventions to increase retesting; improvement of partner-management and risk reduction counselling remain necessary.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Immediate large loop excision results in overtreatment and more after effects and should not be recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show the feasibility and need to remove enough lymph nodes to provide precise prognostic information and adequate local control.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is, therefore, a viable option for emergency services personnel during pre-deployment training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the burr-hole drainage method is simpler to carry out, its use may be preferable.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main determinant of visfatin in T2D patients with DKD is inflammation; in normoalbuminuric patients, a positive link to adiposity and altered glycemic control and a trend towards a negative correlation to uOC was observable; the latter relationship was evident in patients without DKD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the shared risk factors for endometrial hyperplasia and endometrial carcinoma is cigarette smoking.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, especially in high-risk patients, the choice of statin should be based on baseline cholesterol levels and expected reductions in these levels, and treatment should  be adapted if targets are not met.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is also need to negotiate a reasonable device price and maximize capacity utilization.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, we conclude that visceral fat area is positively associated with the prevalence of CRC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "H. pylori infection associated significantly with low serum levels of HDL in the IL-6 -174 CC genotype patients but not in the other genotypes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We studied whether patients are discharged smoothly from the ICU to the general ward.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maternal education programs incorporating information on food safety issues and establishment of breastfeeding-friendly workplaces could curtail the common practice of formula feeding in China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Abnormal ultrasound is associated with CF-related diabetes, and early P aeruginosa is associated with normal ultrasound.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Thal group had a significantly higher recurrence rate of gastroesophageal reflux.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings should be evaluated in a larger randomized controlled trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BC membrane can be used as a dressing for the treatment of varicose ulcers of the lower limbs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study is registered as a clinical trial at the ClinicalTrials.gov (NCT00403676).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children with CSOM were more undernourished than controls with lower mean serum Zn, Se and calcium concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support the hypothesis that optical laryngoscopes can be used successfully by inexperienced anesthetists in simulated difficult pediatric airway conditions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The total off NPI score between the ChEI+ and ChEI- groups were not different, but there were report the trends toward lower depression severity score, aggression/agitation distress score, and antipsychotic dosages use in the ChEI+.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These improvements were greater with a low-fat vegan diet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study may be useful to underline the interest of lumbar support as a complementary and nonpharmacologic treatment beside the classic medication use in low back pain treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Esophageal dysmotilities had a high prevalence in obese patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger prospective studies are required before it can be concluded that this extra surgery should be advised in these patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional precautions should be considered in patients with these risk factors.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Able to reduce intra-operative blood transfusion and medical expense, AHH can be used safely and effectively in posterior spine fusion in children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, it increases the incidence of delayed intracranial hematomas and subdural effusion, some of which need secondary surgical intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CCBT was typically rated favourably by patients referred to a secondary care service and randomised to treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These hormonal changes are independent of inhibin B.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A population-specific understanding of preexisting lead exposures can enhance postarrival lead-poisoning prevention efforts, based on Centers for Disease Control and Prevention recommendations for resettled refugee children, and can lead to remediation efforts overseas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both long sleep duration and afternoon napping were independently and jointly associated with higher risk of incident diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Different results obtained in the relative bioavailability between TDS-testosterone and Androgel for uncorrected data and corrected data, suggests that correcting endogenous concentrations is important for the proper determination of bioequivalent for endogenous compounds such as testosterone.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings provided evidence for nurses to use soothing music as a research-based nursing intervention for intensive care unit patients' sleep improvement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggested that DEX treatment during surgery significantly reduced POD incidence in both normal and aMCI elderly patients, suggesting that it may be an effective option for the prevention of POD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings highlight another end-organ effect of uncontrolled glucose levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The dairy value chain was a successful strategy to distribute MNFY among pastoralists in Northern Senegal, and increase Hb concentrations among their children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, the results of our population-based case-control study support a putative role of the CLOCK gene in the development of breast cancer in shift workers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Apelin may not be directly involved in the regulation of maternal insulin sensitivity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low carbohydrate diet is a feasible option for people with type 1 diabetes, and may be of benefit in reducing insulin doses and improving glycaemic control, particularly for those wishing to lose weight.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the increased safety profile and greater efficacy of other surgical techniques, LAGB utilization should be discouraged.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutritional risk was detected in 30% of ambulatory ADPKD patients with relatively good renal function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vitamin deficiencies are common in patients with tuberculosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This innovative protection device may prevent the debris released by angioplasty from entering the cerebral circulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hyperthyroidism should be considered in patients presenting with unclear symptoms and mildly elevated natriuretic peptide levels, as overt hyperthyroidism results in increased serum A- and B-type natriurectic peptide levels, typically seen in mild heart failure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that public health stigma-reduction strategies which aim to promote engagement with mental health services should be focused towards people who are experiencing worsening mental health.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Phyto-oestrogen can be used as an alternative to clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional therapy may be necessary to enhance long-term results.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sterile water is an inexpensive alternative to isotonic saline for irrigation during PCNL.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Still, although no direct association between DP and torticollis was found, cranial shape is linked to cervical motion at birth.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed on the effect of chronic inflammation and infectious disease on anaemia in elderly women in rural China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The target depth of the real-time feedback device should be at least 6 cm but should not exceed 7 cm for optimal CC on patients on hospital beds.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study shows that the implementation of a POC PCT-guided algorithm can be used to substantially reduce antibiotic exposure in patients hospitalized with AECOPD, with no apparent harm.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies aimed at characterizing these changes are needed to provide insight into the connection between obesity and its comorbidities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While WinS may create an important enabling environment, WinS interventions alone and as currently delivered may not be sufficient to independently impact pupil education and health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "25-hydroxy-vit D deficiency is frequently observed in patients with SpAs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aerosolized buccal or intranasal midazolam represents an effective and useful alternative to oral midazolam for sedation for laceration repair.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Double-blind, placebo-controlled studies are needed to verify whether pentoxifylline can improve olfactory sensitivity in patients with olfactory disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Number NTR3400 ; date April 4th 2012; retrospectively registered.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of pantoprazole as a BCRP inhibitor should be revisited when characterizing BCRP-mediated transport in humans.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may have implications for the evaluation of and treatment decisions for patients referred for TAVR with significant PH.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whole-mouth mean and worst-site ACH were associated with increased lung cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "National programs should be maintained to encourage physical activity and weight reduction as well as focusing on obesity-related lifestyle and behaviors at early ages to prevent weight gain and possibly muscle wasting with age.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is scope to enhance cross-disciplinary collaboration in the development and implementation of a Healthy University settings-based approach to health promotion in tertiary education workplaces.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These eyes/patients should be selected for inclusion in future clinical trials of drugs targeted to prevent diabetic retinopathy progression to vision-threatening complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We concluded that a positive association between serum PTH concentration and metabolic obesity among female subjects and an inverse relationship between serum 25(OH)D levels and the risk of metabolic obesity were  found among male subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The delivery of loxapine by inhalation may provide a rapid, well-tolerated option for treating acute psychotic agitation that allows patients to avoid the aversive effects and loss of autonomy often associated with use of intramuscular medications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EEN using a jejunal feeding tube in neonates who have undergone a partial gastrectomy for gastric perforation is safe, easy, and has fewer complications than TPN.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observational data show the progress made in the treatment of ACS from the acute phase up to 3 months, and highlight key areas for improvement  in the prevention of recurrent events in patients with CHD in France.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Controlling for randomisation, 12-month insulin use was predicted by higher baseline HbA1c and 'willingness' to use insulin if recommended.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LPLC should be considered in all patients undergoing laparoscopic cholecystectomy, especially those patients with compromised liver functions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cross-cultural communication and team-based care were reported as fundamental to successful preconception care in women with T2DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The healthcare provider should provide information and help to direct the subject toward the most clinically appropriate oxygen system, while being mindful of the patient's preferences and lifestyle.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recombinant IL-2 is recommended for treatment of children with encephalitis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the rate of diabetic ketoacidosis was higher in the sotagliflozin group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A definitive trial comparing the efficacy of nutritional support interventions in increasing weight and BMI in malnourished care home residents can be conducted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the patients considered controlled, with normal a normal age-adjusted IGF-1, presented higher scores in SF-36, in physical and emotional domains, compared with patients with persistent hypersomatotrophism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also offers the advantage  of enabling simultaneous sentinel lymph node biopsy for invasive cancers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity is likely under-diagnosed using the standard WHO and NCEP-ATPIII guidelines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide partial support for theorised mechanisms of SMR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvements in NAFLD occurred rapidly after bariatric surgery and were closely related to weight loss and metabolic factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ROC-derived cut-points can be used to classify youth SB with the wrist and with vector magnitude data.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are necessary to confirm the decreased ETP following LBS with the expected reduced inflammatory marker and total cholesterol levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrated that preoperative prealbumin, BMI, and NLR were independent prognostic factors of AEG patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results were better in patients treated with more potent statins and cardiologists advised them much less frequently to change the type and dosage of statin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, https://clinicaltrials.gov, NCT00000611.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest a bidirectional relationship between information  satisfaction and symptoms of depression and anxiety.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vitamin D insufficiency was common in young children with fractures but was not more common than in previously studied healthy children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Absence of a correlate does  not obviate the need to biopsy suspicious non-mass enhancement.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fast track does enhance recovery and is suitable for unselected patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measuring steps per day may be a feasible and more effective way to screen for physically inactive patients than self report.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study findings suggest that although WV nutrition interventions  have shown impact, there is also a nonnutritional pathway of child stunting in rural Armenia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In HF patients with electromechanical cardiac dyssynchrony, functional improvement related to CRT is associated with favorable changes in established molecular markers of HF, including genes that regulate contractile function and pathologic hypertrophy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-dose oral esomeprazole at 40 mg BID may be considered as a useful alternative to IV bolus plus infusion of esomeprazole in the management of ulcer bleeding in patients who are not candidates for high-dose IV infusion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that failure in the level I-II axilla is an uncommon occurrence after modified radical mastectomy and chemotherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of this study demonstrate the benefits of treating diabetic foot infections at a specialized wound department with a multi-disciplinary team.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Collectively, these findings indicate that energy-matched high intensity and moderate intensity exercise are effective at decreasing IHL and NAFLD risk that is not contingent upon reductions in abdominal adiposity or body  mass.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such visits may need to be specifically focused on a range of issues related to the specific reasons why patients are rehospitalized.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of an in situ stent did not interfere with surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In postmenopausal women, Tao Brush sampling offers advantages over use of Pipelle, and the former should be considered as an alternative or additional sampling device in this group of women.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The postoperative FRV and renal function could be predicted preoperatively using a 3-D image reconstructive system, preoperative routine diagnostic imaging, and preoperative sCr level.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There remain polarized views on the best surgical approach to malrotation yet a persistent belief in the reduction in postoperative adhesions in leading to a postoperative volvulus with LL procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This minimal-contact approach addresses the need for interventions in primary health care settings and may be a useful component in step-care models of mental health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "OGTT and HbA1c identified two different populations of patients with dysglycaemia with the HbA1c criteria missing almost half the patients with T2DM based on OGTT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with A-T decline in growth over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most of the diarrhea subsided in less than 7 days of admission with proper management and aggressive nutrition upon admission.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the primary indication for surgery was excess skin and not diastasis of the rectus abdominis muscles, there is a need for future trials before conclusions can be drawn of effect of abdominoplasty and plication.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, SAB had no effect on either length of hospitalization or patients' postoperative functional status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with tocilizumab and rituximab reduces PWV, a marker of CVD risk, in patients with RA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study revealed that obesity and abdominal obesity, which differed by gender and age, are epidemic in southern China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possible explanations may involve characteristics of the website itself, its use by participants, or methodological reasons.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, percutaneous 915 MHz MW ablation may provide a new method for the treatment of large HCC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An anti-rotavirus vaccine has already been introduced in Madagascar and should be promoted more widely.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The multifactorial nature of nocturia supports the delivered management and treatments being targeted to underlying etiologies in order to optimize womens symptom management.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A macular hole is formed when the anterior cyst wall containing Henle's fiber layer is operculated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, desflurane and sevoflurane can be considered as suitable for emergence in pediatric neurosurgical anesthesia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The quality of life of these patients, after massive weight loss, is also highly improved by these procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to create smoke-free homes should address enforcement challenges as newly adopted rules may be fragile in some households.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Certain reproductive factors may have a greater impact on the risk of certain molecular subtypes of disease compared with others.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, there are only a few, well-designed and controlled studies  that compare hospital care to different models of home care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efforts to prevent fetal growth faltering must begin early in pregnancy and perhaps even before pregnancy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low-intensity ORLA, delivered by computer to individuals with chronic nonfluent aphasia, is efficacious and may be equivalent to ORLA delivered by an SLP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oral examination practice may be of value in training for future examinations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These preliminary results on a small group of healthy high risk patients suggest  that the diagnostic abilities of ABVS are inferior to MRI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Beginning in 1999, we implemented a strategy for reducing infection by MRSA that included nasal mupirocin ointment for patients at high risk of MRSA; since then, the detection rate has decreased.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that TCI can be used to provide routine sedation for patients receiving GI endoscopy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, these results should be confirmed with further studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that higher than while sedentary behavior is related to worse fasting glucose, this relationship is attenuated when PA is taken into account.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A longer follow-up evaluation is required to accurately describe and assess specific risk factors for complications in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Removal of uterine myoma was not associated with decreased risk of breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of the present study suggest that both vitamin E deficiency  and oxidative status are associated with prediabetes in apparently healthy subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its use can significantly lower the usage of iodinated contrast and the number of selective cerebral circulation injections while not prolonging the length of the procedure or the fluoroscopy time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In adults with ADHD, PoA scores indicated impaired attention at baseline and response to treatment with LDX and MAS-IR (vs. placebo), demonstrating value for measuring the time course of pharmacologic treatment effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the challenges, this study should provide valuable information about the effectiveness of electronic health record-based tools for addressing overweight and obesity in primary care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, bigger studies with longer-term follow-up are needed to confirm these findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dulaglutide improved glycemic control with the potential for weight loss in Hispanic/Latino patients with T2D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The BMRP surgery could be an alternative procedure to BMRR for the treatment of CI-type IXT with less immediate postoperative overcorrection and simpler, safer, less traumatic characteristics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study substantiated the associations between four previous reported genetic variants and stomach cancer susceptibility in an independent Han Chinese population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the current pilot study suggest the promise of AIM-FBCR in reducing FCR in survivors of breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, training and experience of nurses in aromatherapy massage is critical to achieving positive results.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results are encouraging and demonstrate that  exercise was popular and conveyed benefit to participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data provide evidence to support opioid switching to improve outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If appropriate recruitment strategies are used, this pilot study demonstrated that it is feasible to conduct a secondary prevention trial of periodontal therapy in patients who have had coronary heart disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In studies of obesity and PCa, differences in prostate volume cause  a bias toward the null, particularly in analyses of non-aggressive PCa.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "\u221a\u00a2\u201a\u00c7\u00a8\u2248\u00ecMetformin decreased the BMI z score and improved inflammatory and cardiovascular-related obesity parameters only in prepubertal children, but a differential effect of metformin was not observed in prepubertal compared to pubertal children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New mothers require help and reassurance independent of whether this is their first or subsequent child, reinforcing the need for support, breastfeeding information, and education about normal neonatal behavior.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions aimed at modifiable correlates may include maintaining a normal body weight and regular physical exercise for maintaining a  normal waist circumference, and decreasing caffeine consumption, implementing feasible modifications in sleeping environments and maintaining sleep hygiene to  improve sleep quality.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Masking is predicted by PDA, and not by BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BRBC does not improve survival of women with MBC in this study, though longer follow up is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Peer-assisted learning may be a useful teaching method for simulation training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our trial, inclisiran was found to lower PCSK9 and LDL cholesterol levels among patients at high cardiovascular risk who had elevated LDL cholesterol levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Presence of diabetes mellitus is the most important risk factor for retinopathy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings indicate that Chevron-Akin double osteotomy is a save and practicable procedure for the treatment of mild-to-moderate hallux valgus.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients present differently and therefore require tailored interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies are needed to determine appropriate insulin adjustments based on glucose trend data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Community-dwelling older adults with a history of falls should be provided with center-based programs in preference to home-based programs where they are available.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings should encourage future research on the possibility of amelioration of attention difficulties in patients suffering from ADHD by using high frequency rTMS directed to the right dorsolateral prefrontal cortex.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HIV prevention and control strategies are urgently needed in this population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Total and HDL cholesterol concentrations are subject to slight variations in relation to the duration of the pre-phlebotomy fasting period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increasing the adherence to healthy lifestyle behaviors might strengthen and balance body constitution, which could improve supportive care in breast cancer survivors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Green tea consumption and green tea consumption with non obese group seemed to have a protective effect for lacunar infarction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The optimal range to maximize ROM for postoperative anterior disc height is 16 mm to 18 mm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our cohort increased left ventricular output and lower mean BP predicted a clinically significant PDA requiring treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach has the potential to improve cancer-screening rates significantly in settings that can provide telephone support to women known to be overdue.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diagnostic work-up for vallecular cysts should include a detailed medical history, complete head and neck examination including endoscopic examination, and appropriate imaging, as each of these components complements the histopathologic findings.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health professionals should account for dietary supplements when assessing diet.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since Internet compatible mobile devices have become widely available, a significant quality improvement in bystander first-aid seems possible.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum concentrations of Fe and Ca did not show any difference between two groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given this non-inferiority for UVB nb monotherapy, the recommendation of adding UVA to UVB nb phototherapy for pruritic inflammatory skin disease should be abandoned.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; Teen-LABS ClinicalTrials.gov number, NCT00474318.)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results add support to evidence suggesting that urodynamic assessment is not a prerequisite for the treatment of overactive bladder (OAB).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the risks for cardiovascular outcomes were not elevated in DPP-4i-treated patients compared with sulfonylurea-treated patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A well-powered randomized trial of CABG versus PCI in the ACS population is warranted\\xa0because these patients have been largely excluded from prior trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because the plug is simple to apply and minimally invasive, it can be considered as an initial treatment option for high transsphincteric fistulas.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contrastingly, abdominal obesity, when adjusted for BMI, yielded results in the opposite direction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings have translational implications for conditions associated with early risk for social-emotional growth, including autism and prematurity, without the need to administer drugs to young infants.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both face-to-face support and telephone support proved to be effective in increasing the physical activity level and mental health of university employees.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide a baseline measure of the sympathetic response to spinal manipulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If patients understand why a behaviour is beneficial, they perceive it as acceptable to participate in and that they have control over the decision to engage in the behaviour, we hypothesise that more patients will intend to participate in that behaviour.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For all treatment groups, older age, better baseline VA, larger CNV area, predominantly or minimally classic lesion, absence of RAP lesion, presence of GA, greater total fovea thickness, and RPE elevation on optical coherence tomography were independently associated with less improvement in VA at 1 year.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risks of metabolic deterioration and CACS progression were significant in subjects with MHO class I, but not in those with MHO class II.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The procedure is simple, safe and rapid, and it should be considered in all patients undergoing transrectal ultrasound guided prostate biopsy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, post-licensing surveillance is required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the standard dose of 0.1 mmol/kg provides overall better image quality, with the best performance obtained at the delay of 10 min or more after Gd-BOPTA administration, and it should be routinely preferred.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed associations between pre-diagnostic serum GGT and different breast cancer subtypes may indicate distinct underlying pathways and require further investigations to tease out their clinical implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with diabetic retinopathy, we confirmed the increase of hemoglobin oxygen saturation as in the arterial as in the venous blood in retinal vessels; and significant decrease of arterio-venous difference according to the severity of diabetic involvement was confirmed as well.Key words: automatic retinal oxymetry, diabetic retinopathy, oxygen saturation, Oxymap.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that TC-coated sutures should be used with caution.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fascia iliaca block may be used as an alternative method to periarticular injection, and it effectively reduces the amount of morphine used to relieve post-TKA pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Shelter staffing plans should not rely heavily on assistance from accompanying caregivers; instead, they should assume a substantial proportion of shelter capacity will be dedicated to non-medically needy persons.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In regions with adequate infrastructure for surveillance and management of complications, health care facilities could consider eliminating the routine use  of antibiotics in protocols for the treatment of uncomplicated severe acute malnutrition.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results support the use of these theory-based strategies to reduce alcohol drinking in excess of guideline limits among undergraduates.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disease management services delivered by PCP-NE demonstrated a trend towards add-on improvements in cholesterol control compared to care delivered by physicians alone; however, the improvements were not maintained when the services were withdrawn.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to improve the nutritional status of children, preventive measures  focused on household and personal hygiene and nutritional rehabilitation during severe diarrheal disease should be reinforced.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Electro-acupuncture is a possible treatment of vasomotor symptoms for women with breast cancer and should be further studied for this group of women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research comparing surgical strategies in these 2 environments could assist maxillofacial surgeons in providing optimal care to their patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of ultrasound teaching to traditional physical examination instruction enhanced medical student competency and confidence with the femoral vascular examination.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Montelukast can be useful in the prevention of LRs after specific immunotherapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Modification and reinforcement of education is needed to achieve better knowledge retention and favorable lifestyle modifications.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study uncovered health-related, arthritis-related, and functional factors associated with MVPA that may help guide intervention strategies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oral analgesia with OOXY after THR offers non-inferior analgesia to IVPCA and may offer some logistical and cost advantages.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Study findings indicate that a heel protector that ensures off-loading and maintains the foot in a neutral position is more effective for prevention of HAPI of the heel and contractures as compared to standard care using pillows to position the heel and redistribute pressure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Enteropathogens were found in only about half of the patients and the most common cause of PD was secondary lactase deficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depressed patients with bipolar disorder and comorbid anxiety may be in particular need of additional psychotherapy for treating acute depression.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the suboptimum effect on functional parameters should be addressed by increased voluntary activation during WB-EMS application.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Antireflux surgery should be individualized to the characteristics of each patient, taking into consideration anatomy and propensity and tolerance of side effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among children with atopic predisposition, the number-needed-to-treat with BCG to prevent one case of atopic dermatitis was 21 (12-76).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that the ADC value is a non-invasive imaging parameter that can help in differentiation of diabetic osteoarthropathy from osteomyelitis  with excellent inter-observer agreement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings underscore the requirement for geriatricians and health professionals to be more vigilant in examining PUs as dementia progresses.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results provide support for the use of AS as a dietary supplementation for improving cognitive functions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endovascular embolization of epistaxis is a safe procedure that can be useful for patients with severe acute epistaxis or chronic persistent bleeding.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients undergoing RYGB who had a substantial drop in REE at 6 months may exhibit less long-term weight loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a strong correlation between bimanual and ultrasound examinations with regard to determining the size of leiomyomatous uteri.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It shortens the endovascular procedure and enables more precise positioning and deployment of stent graft.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Height and weight were the most reliable measurements under the studys conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nearly all were free from vandalism and many had murals or art.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obstetric care provider knowledge of GDM diagnosis might have affected decision-making regarding the route of delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "tDCS should be considered a useful tool for the improvement of language functions in patients with neurodegenerative diseases in future trials.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, when patients must be counseled against physical exertion, they also need to be educated about the importance of appropriate physical activity and good dietary practices.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health practitioners should take possible Internet addiction, online activities, and physical activities into consideration in follow-up of obese adolescents.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exclusively subcortical cavernomas are highly unlikely to cause epilepsy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such youth may require interventions targeting depression.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at clinicaltrials.gov as NCT02090842.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "KEYWORDS Pre-eclampsia, toxemia of pregnancy, pregnancy outcome, environment, genetics, genome-environment interaction, genetic epidemiology, Cuba.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Management of infants presenting with eczema, exclusively formula-fed infants, and first line use of AAF were associated with higher estimates for 2-year direct medical costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results are limited by high risk of bias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the register has not been reported to improve care coordination, it has contributed to increased reported prevalence of gestational  diabetes among high risk Aboriginal women, in a routinely collected jurisdiction-wide pregnancy dataset.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite high rates of cesarean delivery in women with superobesity, labor is associated with lower composite maternal and neonatal morbidity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of HEAAL should facilitate selection of an optimal dosing regimen for losartan in patients with symptomatic heart failure who are intolerant of ACE-inhibitors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is still need for better evidence, first, on what symptoms can or cannot be attributed to teething and, second, on what is effective in alleviating them.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oncoplastic surgery achieves more accurate tumor resection than standard quadrantectomy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A considerable number of patients treated with statins did not achieve the treatment goal values.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study also demonstrates the feasibility of recruiting and retaining eligible women to participate, and the results show that both study intervention and printed materials increase awareness of the importance of breast cancer screening and screening behaviors for Chinese American women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nursing leaders may want to consider use of 3-dimensional VEs as an early method to provide repetitive practice for learning how to navigate a new large-scale space.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides support that the MTHFR 677TT genotype is associated with a moderate increase in risk of postmenopausal breast cancer and that this risk may be attenuated with high intakes of some one-carbon associated nutrients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Risk factor screening methods are poor predictors of which pregnant  women will be diagnosed with GDM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower incidence of heart failure and a possible effect in patients with early anterior ST-segment elevation myocardial infarctions need confirmation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are required to determine the factors for this significant difference in labour outcomes for these two Caucasian groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New age-corrected normal values for version 3.0 should be obtained and made available to users, and new baseline field data should be established whenever a patient is switched from version 2.6 to version 3.0.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, women with vaginal or operative vaginal delivery had a significantly larger hiatal area and transverse diameter than women who delivered by Cesarean section.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first study to report the interaction between obesity and HIF3A gene in relation with ALT, and also to reveal a mediation effect among the  HIF3A polymorphism, methylation and ALT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonetheless, the level of HDLc was negatively associated with the level of the inflammatory marker MRP8/14, which is in accordance with the concept of inflammation as an important driver for premature development of atherosclerosis in JIA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PACCI-ED can be used to improve provider assessment of asthma morbidity during pediatric ED visits for asthma exacerbations, and to identify children who may benefit from interventions to reduce asthma morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obese patients should be considered for reduction mammaplasty surgery in the same way as women of normal weight.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Procedure-specific qualitative metrics are improved with expert feedback, but nonexpert facilitators can also enhance the quality of training and may represent a valuable alternative to expert clinical faculty.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study did not identify variables that robustly differentially predicted treatment effectiveness of CBT and MBCT, indicating that both CBT and MBCT are accessible interventions that are effective for treating depressive symptoms in broad populations with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The perceptual altering effects and lack of euphoric effects would explain its intermittent use pattern.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Above results are the evidence, that cataract surgery is a big trauma for cornea, especially for its endothelium.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further study should also investigate the etiologic role of diet in AP and the molecular mechanisms behind  the development of AP to establish whether AP is caused by exposure to polycyclic aromatic hydrocarbons.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this first prospective comparison of EPclin and uPA/PAI-1 we found, that EPclin is superior to uPA/PAI-1 with respect to feasibility and decision impact.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term survivors of high-risk MI should be followed closely and treated aggressively beyond the acute MI period.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sexual function and satisfaction were affected to a greater extent than body image.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine screening for malnutrition among geriatric patients would allow early diagnosis and prompt intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results may help explain divergent findings in this field of research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DNA double-strand break assessment may provide a strategy for individualised assessments of radiation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PSMVT was found to occur uncommonly after LSG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, obese patients tended to have more favorable pathologic features.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of hypertension and the yearly increase of mean blood pressure were disturbingly high in these patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Yoga is safe and effective in patients taking medications for arterial hypertension and thus can be recommended as an additional treatment option for persons in this category.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrates that live 3DE, easily performed at the bedside, provides incremental information on patients with a variety of congenital heart lesions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results provide a basis for study design and data evaluation in the future development of recombinant FSH products, and show it can be of importance to account for endogenous FSH levels and its variation over time for accurate estimation of exogenously administered FSH pharmacokinetic parameters.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MEN1 is a high-risk condition for the occurrence of ACCs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with GERD with moderate-to-severe regurgitation, especially despite once-daily PPI treatment, should be considered for minimally invasive treatment with MSA rather than increased PPI therapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies with larger samples are needed to further elucidate the relationship between nutrient deficiencies and SCD, and to determine whether nutrient supplementation can improve the disease course.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Seemingly, obvious reasons could not be retained as valid explanations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are clearly some, but possibly limited, etiologic differences between subtypes, with the greatest contrast between luminal A-like and triple-negative subtypes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, we were unable to confirm  the hypothesis that wine drinking is associated with an elevation of HDL (Tab.7, Fig. 1, Ref.30).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results suggest an insufficient control of allergen-specific responses via the Treg-cell compartment under systemic immunosuppression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With many options available for removable retainers, clinicians should consider the BPA release from these retainers; a Hawley retainer fabricated by heat cure is a favorable choice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SEMG might be used as an adjunctive measure of pain behavior via assessment of muscular reactions to pain and to analgesia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the endometrial appearance on ultrasonography appears to reflect secretory transformation, it cannot replace endometrial biopsy for full evaluation of luteal endometrial development.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attention Training seems to be a promising treatment for social phobia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GIC and CR can be used successfully for restorations of one or two dental surfaces after ART.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that for lowering LDL cholesterol concentrations it is not necessary to consume products rich in plant stanol ester at each meal or simultaneously with dietary cholesterol.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of ezetimibe plus fenofibrate appeared to produce nearly identical alterations in serum lipoprotein levels when compared to monotherapy with 10 mg of atorvastatin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, CETP gene variation may affect coronary risk apart from the level of HDL-C.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be an effective approach to solve the dialysis problem for the economically week population in China, especially for people with a smaller body size with lower transport membrane.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ESG could be an alternative to bariatric surgery for selected patients with obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with diabetes, mobile telemonitoring has potential for delivering intensified care to improve blood pressure control, and its use may be associated with reduced exposure to hyperglycemia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to diminish acute bone loss during HCT in children are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For treating postcraniotomy emergence hypertension, nicardipine is a relatively effective sole drug, whereas if esmolol is used, rescue antihypertensive medications should be readily available.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Benign characteristics are present in most invasive cancers \u221a\u00a2\u201a\u00c4\u221e\u00ac\u00a75\\u2009mm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During the same time period, the weight gain of very preterm infants improved, significantly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high rate of injury deaths, especially those due to psychotropic and other medications, should concern providers.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A lower TLR rate and better clinical outcomes appear to be associated with the use of DEBs regardless of stent placement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Potential implications for health behavior theories and behavior change interventions are outlined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here we provide an easy and practical alternative to implement light/dark conditions in the NICU.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other risk factors that were associated with major amputation in patients included active infection at presentation, nonunion/instability after reconstruction, and a postoperative wound problem.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that activity programs with or without an aerobic training component are safe and may result in an important improvement in physical function.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such programs could significantly increase the availability of diabetes prevention programs worldwide making an immediate and significant public health impact.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Glucose control may be associated with breast cancer outcomes\\u2029.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The qualitative findings outlined in this paper offer important insights into why the intervention was not effective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intermediate\" telerehabilitation treatments offering FMT, some face-to-face consulting, and a gym-based exercise location should be pursued as promising alternatives to conventional chronic pain rehabilitation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was also a trending association between immunoglobulin M concentrations and prediabetes prevalence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Telephone screening is a feasible and efficient method for screening moderately injured adult patients for hazardous drinking, but characteristics of the clinical site (including personnel) influence its effectiveness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future decisions for application of the PRP for lateral epicondylitis should be confirmed by further follow-up from this trial and should take into account possible costs and harms as well as benefits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Stunting prevalence may vary across space at different scale.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of patients found visualization of their laryngeal examination during VRL to be helpful.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both methods showed that a 10-mL change in stroke volume during follow-up should be considered as clinically relevant.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In future, PDT should be compared to other strong active treatments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Meta-analysis showed no significant association between HIV-positivity and GDM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The constant presence of ASL staff in school has promoted important changes: cultural change and about the management of allergy and food intolerance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help to inform future iterations of paediatric resuscitation guidelines.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MS in outpatients with schizophrenia may be assessed by either the standard or the modified NCEP ATP III criteria without losing reliability.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by F. Hoffmann-La Roche; dal-OUTCOMES ClinicalTrials.gov number, NCT00658515.)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial in aged white women living in a community dwelling home at risk for osteoporotic fractures confirms that fortification of dairy products with vitamin D3 and calcium should provide a greater prevention of secondary hyperparathyroidism and accelerated bone resorption as compared to non-fortified equivalent foods.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ApoD expression is likely not a predictor of recurrence in tamoxifen-treated patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At month 24, there were significant visual and anatomic improvements in both groups, with subjects in the 0.5 mg RBZ group gaining more vision.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We describe a gene signature associated with immune function and favorable outcome in basal-like breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further longitudinal study is needed to determine how WC and BMI compare in predicting outcomes, particularly for children with CKD identified as having obesity by 1 measure but not the other.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants in SNAP require greater focus to understand and further address their poor health outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant associations were observed between major dietary patterns and risk of diabetes and hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obstetric care providers may use our findings in counseling this special population of prenatal patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Omega-3 and omega-6 FA intakes are inversely associated with inflammatory biomarkers among CVD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This point allowed patients, in non-surgical chronic critical ischaemia, to avoid being confined to bed and to access to benefits of a early physiotherapy, in association with local treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, suturing of the nasal septum after septoplasty should be a preferred alternative to nasal packing.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings do not support the hypothesis that serum cholesterol and suicide attempts are associated among subjects with major depressive disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estimated energy requirement and average protein requirement were clinically validated for prevention of nutritional decline and of impaired healing of deep pressure ulcers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children from different world regions clustered into groups of similar lifestyle behaviors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study population, 2.0 mg RBZ does not appear to provide additional benefit over 0.5 mg RBZ.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Saline is recommended in view of its easy availability and lower costs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of FH was the highest in younger age patients, and >60% of patients with probable FH displayed CHD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clonidine can be used in dorsal penile nerve block to improve and to prolong its analgesic effects after male circumcision.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The detection of the shift of segmental contribution ratio could be helpful for the diagnosis the motion abnormality resulted from the disc or, facet pathologies, and arthritic changes of cervical spine.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conflict of interest statement: This trial was partially funded by MegaGen, the manufacturer of the implants evaluated in this investigation, however data belonged to the authors and by no means did the manufacturer interfere with the conduct of the trial or the publication of its results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found normal fT4 levels in most PWS children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The increased risk of endometrial cancer associated with tamoxifen treatment should be considered clinically for both premenopausal and postmenopausal women during treatment and for at least 5 years after the last treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend that the training is incorporated in postgraduate education for medical specialists and residents who frequently encounter patients with MUPS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Large, randomized trials are needed to further assess these therapeutic alternatives.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aripiprazole can be used safely in combination with SSRIs that have a CYP enzyme-inhibitory action.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant trends were observed for BMI, WC, body fat, visceral fat, and muscle mass for both genders with age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Programs may need to make special efforts to facilitate entry for treatment-seeking heroin users who also use cocaine.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, stone loads greater than normally acceptable can be successfully undertaken in these patients, and should be attempted due to problems associated  with other techniques.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Generally, the nutritional status of patients is screened with unreliable parameters such as clinical observation and body mass index.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An individually adapted physical therapist-supervised home exercise program might be recommended in early active PM/DM, with regular evaluation of muscle performance and health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "sHLA-G concentratons are higher in normotensive overweight/obese women and their babies while lower in preeclamptic overweight/obese women and their cords.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Images produced using the cornstarch-based alternative ultrasound gel were of similar quality to those using commercial gel.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Either plasma total cholesterol-adjusted carotenoid concentration or the integrated biomarker could be used to distinguish between high- and moderate-F&V consumers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A pervasive underestimation of the association between obesity and overall PCa risk may exist in the literature.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that the results of this sub-analysis from the Leaders Free trial are likely to significantly impact clinical practice for high bleeding risk patients presenting with an ACS: the use of a BMS can, in our view, no longer be recommended, and, given the paucity of available data for second-generation DES with shortened DAPT in these patients, the BA9-DCS should currently be considered as the device with the strongest evidence to support its use for this indication.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Observation of a relationship between macronutrient intervention and sustained attention (if one exists) will require further standardization of empirical investigations to aid in the synthesis and replicability of results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physicians were more likely to prescribe high-intensity statins in statin-na\u221a\u00c9\u00ac\u00d8ve patients as compared with intensifying existing statin therapy, and  their prescription pattern was lower after CVA vs ACS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a nominal increased death risk in secondary breast angiosarcoma due to advanced clinicopathological features.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, these novel findings may have important safety implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a greater patient group, these explorative results should now be verified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with placebo, treatment with canagliflozin delayed the rise in serum NT-proBNP and hsTnI\\xa0for over 2 years in older T2DM patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Positive interventions may productively be refined to support people experiencing trauma and loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Constipated patients require a personalized preparation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show that the nature of drug-induced gingival overgrowth differs somewhat between immunosuppressive and nifedipine medications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was also shown that patients with PU have a higher incidence of medical complications, such as acute renal failure, pneumonia, and the need for vasoactive drugs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In multiple regression the combined factors that remained associated with lymphocyte count were NRS and triceps skinfold thickness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the potential clinical utility of the classifier to improve management of patients undergoing bronchoscopy for suspect lung cancer by reducing additional invasive procedures in the setting of benign disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sevoflurane provides clinically acceptable intubating conditions and can be a suitable alternative to propofol-suxamethonium for endotracheal intubation in children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Any abnormal finding in the reports should be investigated in terms of the progress of the pathology and also its clinical consequences.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At present, potential clinical implications of these results remain unclear.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on three independent determinants, a prediction model is developed to identify non-adherent FH patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health care providers, particularly, nurses can provide these two noninvasive and economical interventions simultaneously and benefits the synergistic effect of them in burn patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Anthropometry at 6 weeks and growth in infancy independently predict size in midchildhood, while anti-flagellin IgA, a biomarker of environmental enteric dysfunction, in early infancy is associated with increased blood pressure in midchildhood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of elevated blood lead levels among tested US-bound Burmese refugee children was higher than the current US prevalence, and was especially high among children <2 years old.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide quantitative, rigorous evidence for the importance of context or unmeasured individual-level compositional variables in modifying MTO's effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should be taken into consideration when choosing between these 2 procedures for preterm infants who undergo urine sampling.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABO group is suggested as a possible protector marker for GDM.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "KEY POINTS Middle age, low education, and low income were associated with nonattainment of goals for diabetes care, especially for lifestyle goals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The BDNF system may be implicated in the pathophysiology of TD and its improvement with antioxidant treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Apical anatomic success rates are high and not affected by concomitant Burch.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be regarded as an index for the relationship of apoA-I and apoB to the early, still clinically asymptomatic, steps of the pathogenesis of coronary disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This might be the result of an adaptation process achieved through a decrease of growth velocity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IBD patients develop NAFLD with fewer metabolic risk factors than non-IBD NAFLD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that iNO may be a useful clinical adjunct to mitigate right heart failure and improve survival when trauma pneumonectomy is required.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health education programs among the study population could be effective for solving the problem.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although SBS and ARI scores were not significantly different for the two adhesives, clinicians need to take into consideration the other properties of the adhesives before using them.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have important implications for patients with impaired glucose metabolism in the future settings of CCR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Small LSG  at baseline is at higher risk of dilatation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hyaluronic acid vaginal gel may be considered as a valid alternative to estrogen-based treatments in relieving the symptoms of vaginal dryness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical lipoatrophy was partly reversible, and <36 months on stavudine was significantly associated with atrophy reversal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In advanced-stage type 2 diabetes, TeLiPro can improve glycemic control and may offer new options to avoid pharmacological intensification.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this prospective study, a higher baseline dietary energy density  was associated with higher incidence of type 2 diabetes among postmenopausal women, both overall, and in women with elevated waist circumference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the scaling exponent using CSA may not be appropriate for individuals with biceps CSA>30 cm.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cricothyroidotomy in trauma patients may be used long term without any increase in acute complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first report of severe hepatotoxicity with available liver histology and genetic assessment of enzymes involved in regorafenib metabolization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dual-frequency ultrasound may be an additional treatment option for rosacea that is resistant to other treatments.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even though iodine status was progressively worsening with the advancement of pregnancy and iodized salt consumption has not met with the increasing demand for iodine, it was not reflected in the serum TSH level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, 5-0 poliglecaprone-25 provides a comparable and cost-effective alternative to nonabsorbable sutures for epidermal approximation in layered closures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A daily evaluation to check readiness for weaning combined with a spontaneous breathing test reduced the mechanical ventilation duration for children on mechanical ventilation for >24 hrs, without increasing the extubation failure rate or the need for noninvasive ventilation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with PCOS risk, and that A allele is a risk factor for PCOS susceptibility simultaneously.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rivastigmine patches have a tolerability profile similar to that shown by capsules, but are associated with greater patient satisfaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is no evidence to recommend the routine use of rofecoxib or similar COX-2 inhibitors after inguinal hernia surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decrease in alertness following therapy sessions must be taken into account in planning rehabilitative measures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Progression of small AAA seems to be more than 60% lower in patients with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Text-based lapse support should be developed and evaluated, especially for women.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrated some clear evidences that acupuncture can be a useful adjunctive therapy to improve nutritional state of COPD patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the whole sample had a high prevalence of cardiovascular risk factors such as smoking, obesity, and physical inactivity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bilirubin may be a biomarker of AECOPD risk and may be a novel therapeutic target to reduce AECOPD risk.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The weight criteria established by the manufacturer may need to be readjusted to recommend a larger size device in some patients less than 90 kg because all of the repeat insertions were in patients weighing more than 80 kg.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In utero ETS and ETS exposure during childhood and adolescence were associated with increased risk of breast cancer and associations varied by birth  cohort.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Concerning patient symptoms, we did not find any objective reason to  justify implant explantation of PIP&Rofil implants as a solely precautionary measure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unhealthy longitudinal triglyceride development is strongly affected by ZNF259/APOA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PVP has added advantages of lesser blood loss, lesser need for blood transfusion (especially for prostate volume 50-80 cc), and shorter catheterization time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with chronic rhinosinusitis with NP (CRSwNP) who were symptomatic despite high rates of prior intranasal steroid use and/or surgery, EDS-FLU produced statistically significant and clinically meaningful improvements compared to EDS-placebo in multiple subjective and objective outcomes (symptoms, SNOT-22, RSDI, SF-36, PGIC, and NP grade), including all 4 cardinal symptoms of CRSwNP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High lignan and yogurt consumption is associated with a better cardiovascular risk parameters profile in an elderly Mediterranean population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The methodologic details of this large collaboration may assist researchers conducting similar investigations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ON-Q\\xc2\\xae system is a viable option for postoperative pain management in children undergoing urological surgeries.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baricitinib-associated increases in serum lipid levels were observed  in this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specific changes of local and lymph node recurrence can be found in the course of the cardinal peripancreatic vessels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To avoid prolonged cannulation and unnecessary radiation exposure, patients should have a liquid fatty meal before ERCP procedures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABBREVIATIONS: AE = adverse event AWARD = Assessment of Weekly AdministRation of  dulaglutide in Diabetes BID = twice daily CARMELA = The Cardiovascular Risk Factor Multiple Evaluation of Latin America CI = confidence interval GLP-1 RA = glucagon-like peptide-1 receptor agonist HbA1c = glycosylated hemoglobin T2D = type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The monotriangular method of upper eyelid fascia sling placement can be used instead of the more popular bitriangular method.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New eradication treatment strategies must be performed, at least in Turkey.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The etiology of anemia appears to be iron-related and precipitated by the female sex.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In newly diagnosed severe OHS, Bi-level PAP and CPAP resulted in similar improvements in ventilatory failure, HRQoL and adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings enhance understanding of individual, social/structural, and health care factors correlated with CBE among LGBQ women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The educational programme including peer discussions using existing opportunities with no need for additional absence from the workplace might be a useful complement to formal large group education for the providers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The absence of two mtDNA mutations  in ND1 gene rules out the possibility of involvement of these mutations in early  onset diabetes in Pakistani population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Those factors might be taken into account before accept or not a 3rd hour at full cervical dilation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An urgent need exists for earlier HIV diagnosis  and better prevention of dyslipidemia in China.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data suggest that perception of neighborhood safety may be associated with overweight status among urban adolescents in certain racial/ethnic groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Beliefs pertaining to antibiotic use were based on utility, gravity of need and perceived efficacy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Family preference for data collection approach should be obtained at enrollment, should be modified as needed, and requires flexible options, training, intensive staff/family interaction, and patience.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach may, however, be difficult to implement on a large scale.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When parents begin amblyopia treatment for children without strabismus, they should be warned of the possibility of development of strabismus, although it is most often a small angle deviation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, total lymphocyte count may be considered a nutritional marker.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, IR may be accused of causing detrimental effect on male infertility due to hyperinsulinemic state and being one of the components for MetS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than half of fall patients had an adverse event within 6 months  of presenting to the ED after a fall.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gore-Tex thyroplasty enables a less invasive procedure with a shorter surgical duration and easier adjustment of medialization due to its flexibility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Def-ET in endometriosis-affected women was associated with significantly higher cumulative ongoing pregnancy rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Changing patterns of HIV transmission suggest a need to concentrate on heterosexual transmission as the main problem in the future.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the  Romanian iodine fortification programme reflected onto its UI levels, a representative assessment of iodine status in Cyprus will address the necessity of an iodine fortification programme.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carotid intima medial thickness was not increased in subjects with acromegaly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Current Controlled Trials TPECTR09831410900 , registered on 24th Dec 2009.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The scope and nature of the biomarkers impacted by AMG 811 support targeting of IFN\\xce\\xb3 as a therapeutic strategy for SLE.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Greater prepubertal weight and earlier pubertal onset are associated with lower adult breast density, but age at pubertal onset does not appear to have an independent effect on adult density after controlling for childhood adiposity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relative risk of HFpEF increases with increasing cardiac radiation exposure during contemporary conformal breast cancer radiotherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This training regimen could be used as an adjunct or even alternative to traditional balance and/or resistance training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion the sciatic-femoral nerve block is a valid alternative to spinal anesthesia for arthroscopic knee surgery, leading to a faster discharging from the hospital.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be concluded that air-oxygen mixture (Inspired O2 50%) anaesthesia should be recommended as being more reliable in tympanoplasties and other middle ear interventions than a N2O-O2 mixture (Inspired O2 30%).", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such information may help clinicians anticipate responses to routine vitamin D supplementation in pregnancy and identify those who may need more support to comply.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At -70 degrees C, the freezing time should be no less than 90 s.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The adverse effect of high BMI on PF trajectories appeared to be more pronounced in men than in women, making more extremely obese Russian men  an important target population to prevent/slow down the process of decline in PF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because a biopsy is indicated for persistent palpable masses, the addition of diagnostic MRI only adds another step, with associated costs and burdens.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This indicates that TY, MBCT and CBT can be used as both treatment and prevention, to improve HRQoL in patients on sick leave because of burnout, reducing the risk of future morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The surgical strategies should be adapted to the patient on the basis of a multidisciplinary approach.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Introducing free GP visits for under-25 year olds living in rural and lower socioeconomic areas in New Zealand was associated with a significant increase in testing and detection for C. trachomatis in the target age group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dose modification of immunosuppressants post-LSG may not be necessary aside from standard therapeutic drug monitoring.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential application of this strategy deserves the attention of health planners.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence that both obesity and unexplained weight loss may be important predictors of suicide.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with pleural metastatic disease, visceral pleural invasion is the only significant factor associated with positive pleural fluid cytology.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High intake of fruit and vegetables was associated with low risk of  ischemic heart disease and all-cause mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One possible explanation is that depression reinforces fatigue, which suggests that treatment should be focused on all aspects of emotional well-being.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that longer quiescent waiting period between active herpes zoster ocular involvement and keratoplasty may promote better visual results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary cholesterol intake did not have an association with LDL-C level or with risk for coronary artery calcification in apparently healthy Korean adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum lipid levels could be a useful predictor for intervertebral disc degeneration in Chinese population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breastfeeding promotion should focus on US-born women and exclusive breastfeeding.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of the interlocked barbed polyglyconate suture technique prevents slippage, precluding the need for assistance, knot-tying and constant reassessment of anastomosis integrity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the importance of widespread assessment of health, including functional vision, to prevent balance impairment and maintain independent mobility among older population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The VGR can be incorporated into computer-dosage programs, and may offer additional safety when oral anticoagulation is monitored.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A physical activity-friendly school environment is associated with lower risk of obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mutations in the SDHB gene are associated with worse disease-free survival after resection in patients with carotid body paragangliomas despite earlier intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with NSN metastases could not be reliably identified prior to CLND.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should explore whether tailoring of iCBT programs improves acceptability and adherence, and evaluate the long-term outcomes following iCBT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2017;123:759-68.\u221a\u00c7\u00ac\u00a9 2016 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no effect on lumen volume, fibro-fatty and necrotic tissue volumes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The fixed-dose combination of aceclofenac and drotaverine should therefore be considered as a suitable, effective and well tolerated treatment option for primary dysmenorrhoea.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative IGB treatment in morbid obesity has not been found to be effective at decreasing postsurgical morbidity LSG and LGBP, despite the fact that it acheives a greater weight loss than diet and exercise.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that the population of infertile men should be carefully screened to identify and treat those with erectile dysfunction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Resveratrol supplementation increased PTX3 and TAS levels in a dose-dependent manner in T2DM patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are negative correlations between hearing recovery and Non-HDL-C, TC and TG levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The package provides clinicians with the option for immediate diagnosis and treatment of non-malaria fevers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings add to the evidence of an increased risk of surgery for SIS in relation to occupational cumulative mechanical exposures, even when an increased risk in relation to BMI, smoking and diabetes mellitus is taken into account.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A single oral dose of \\xe2\\x89\\xa420 mg prednisolone before third molar extraction may not be helpful for the relief of postoperative symptoms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Symptom-specific outcomes were better in patients managed surgically  for PACG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Superficial CPB is an alternative to combined block for MIP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The development of different types of toxicity was unpredictable, but we found that measurement of meTIMP early in the steady state phase helped to identify patients at risk of developing myelotoxicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CBT may work more quickly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with previous hypertensive pregnancy disorders have higher glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels measured after pregnancy compared with women with previous normotensive pregnancies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dhps-437 and dhps-540 are strongly associated with SP treatment failure and should be evaluated further as a method for surveillance of SP-based therapy in DRC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of the FOBT in-hospital may lead to inappropriate management of patients, increased length of stay and increased direct medical costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In general, it  is recommended that the band be removed at the time of the diagnosis of the BE.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, this FFQ is suitable for the investigation of nutrient-disease associations in future.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, it may be used to promote perioperative vascular healing and to support cell replacement therapies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consideration should be given to the NSAID effect in designing clinical studies which use US to assess response to therapeutic.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial demonstrated the feasibility of automated recruitment and randomisation methods into a randomised controlled trial performed in primary care.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intraoperative use of a hand-held gamma detector can help to improve the radicality of a completion thyroidectomy procedure after an incomplete primary thyroid resection, but the results of this procedure in the hands of an experienced surgeon are comparable whether or not the gamma detector is used.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be attributed to the frontal-subcortical circuitry dysfunction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subjects with PAD and diabetes have poorer lower extremity function  than those with PAD alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The seroprevalence of atrophic corpus gastritis in this primary care community is 3.4%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Encouraging MDR TB cases for smoking cessation through awareness activities should be a priority.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Minimization of procedure-related anxiety in younger children and improved nausea control in older children and those receiving more intensified treatment should be prioritized.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These outcomes, associated with increased risks of harm, provide evidence that the maximal allowable red cell storage duration should be reduced to the minimum sustainable by the blood supply, with 35 days as an attainable goal.REGISTRATION.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by the Medicines Company; ORION-1 ClinicalTrials.gov number, NCT02597127 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ability of mometasone to prevent or prolong the time to relapse among subjects undergoing FESS is important because this may prolong the time to subsequent surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypercholesterolaemia is nonspecific but may be a helpful pointer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov, NCT00876395 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is not possible to estimate absolute risk of VTE among women with both of these risk factors; however, the absolute risk of VTE in healthy women of reproductive age is small.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Pfizer; SPIRE ClinicalTrials.gov numbers,  NCT01968954 , NCT01968967 , NCT01968980 , NCT02100514 , NCT02135029 , and NCT02458287 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pedometers appear acceptable to women, particularly at a perimenopausal age, when it is important to engage in impact loading activities such as walking to maintain bone mineral density.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The randomized trial provides insufficient evidence to recommend the routine use of (131)I-lipiodol in these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This bibliometric study is likely to include a list of intellectual milestones focused on microbiota of diabetes research in the past decade, which provides insights into the circumstances and trends in preventing and treating diabetes from a new perspective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breakfast frequency could be negatively associated with abdominal obesity, especially among smokers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is a substantial figure and provides one indicator of the ongoing value of the treatment that the services provide.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endoscopic band removal can be utilized with patients who have a more advanced BE and migration into the gastric lumen.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on our study results, azithromycin can be used in HP eradication regimen because of its similar efficacy to clarithromycin but also have lower cost, side effects and resistance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the future, understanding dietary patterns and acculturation process may be important for health immigrant  studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Support limb laminitis is a relatively common complication among horses treated with half limb, full limb and transfixation pin casts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Expansions of PTV were recommended >2.5 times more often than reductions and >3 times more often than OAR expansions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Very subtle findings in MRI are often associated with histopathological lesions and should be described in MRI reports.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As both mouthwashes showed significant effectiveness on antibacterial activity in individuals with fixed orthodontic appliances, neem mouthwash can be used as an alternative to CHX.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The breast-related stereotype threat was common in patients with breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When using the Digora Optime(\\xc2\\xae) system, the 'Sharpen' filter is recommended to improve the radiographic detection of vertical root fractures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This impairment is directly related to the duration of active disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the value of partner treatment in secondary prevention of sexually transmitted diseases, this video may be an essential component of discharge programming in urgent care settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, some addiction pharmacotherapies, such as disulfiram, may be associated with poorer outcomes among women relative to men and point to the need for careful assessment of pharmacological treatments in both sexes prior to widespread clinical implementation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There may be important benefits to spatially aware handheld displays in reducing errors relating to common navigation tasks.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Phytothermotherapy may therefore be a useful aid alongside the usual pharmacologic and physiokinesic therapies, or may be used as a valid alternative for patients who do not tolerate pharmacologic treatments.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Needle-knife fistulotomy is safe and can be applied as an effective alternative to standard technique for common bile duct cannulation in expert hands.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings showed that Cumulus can be used to measure density on all types of digital images.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intervention should be disseminated to postal stations nationwide and possibly to other occupational groups that work outdoors.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by the Juvenile Diabetes Research  Foundation and others; AdDIT ClinicalTrials.gov number, NCT01581476 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Family physicians most commonly provide asthma care to these young adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be a safe alternative to laryngeal mask airways in day care surgeries.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings indicate a reluctant attitude towards discontinuation of immunosuppressive treatment in AIH patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DP and torticollis are common and minor cervical imbalances very common in normal newborns.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The NFFD prenatal combined lifestyle intervention had a significant effect on TPA-level in late pregnancy among women entering pregnancy normal-weight or physically active, thereby preventing the downward trend typically seen during pregnancy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight reductions to achieve MCIDs for most HRQL instruments are markedly higher than the conventional threshold of 5% to 10%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The investigation of these interactions in larger studies is needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We think that it is important to use IONM to decrease the identification time of RLN in the course of thyroidectomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results should be included in preoperative counseling and follow-up of future patients eligible for vulvar reconstruction with a lotus petal flap.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Present results confirm that in Italy, nutritional care routines are  still poor and need improvements.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A consistent definition for conversion in laparoscopic colonic resection is required.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of activin A with TGF-\\xce\\xb21, eosinophils and RBM thickness may indicate a role of this cytokine in the inflammatory and remodelling process in SRA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modest increases in the donor age of corneas transplanted is a positive finding, but wider acceptance of older corneal donor tissue should be encouraged based on the 5-year evidence generated by the CDS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this largest published cohort, secondary banding of failed RYGB provides only limited additional weight loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on these findings, it is appropriate to use a 1.0-W power output setting with an Er,Cr:YSGG laser for root scaling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wide variation in the relative reduction in cholesterol levels was also observed among patients in whom antidrug antibodies did not develop.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maximum benefit can be gained if we adhere to strict selection criteria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12616000350426 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, with low auxiliary treatment rates, observation may be an option for the management of nonsymptomatic small-sized lower pole kidney stones.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TG has significant correlation with the severity of hearing loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-dose caudal morphine with bupivacaine delayed the need for rescue morphine analgesia in stage 3 patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intravenous esomeprazole is an acceptable alternative to the oral formulation for treatment of up to 10 days of duration.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This method has the potential to reduce unnecessary hospitalizations and exposures to antibiotics in this vulnerable population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although screen failures in the form of diagnostic false negatives occur within the Finnish screening program, their effect on cancer incidence is fairly small and cannot be readily decreased without sacrificing the high specificity of screening or without high incremental costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Abbreviated behavioral counseling can produce clinically meaningful  weight loss regardless of whether self-monitoring is performed on paper or smartphone, but long-term superiority over standard of care self-guided treatment is challenging to maintain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endovascular treatment of arterial aneurysms was effective and safe, with an acceptable vascular complication rate and excellent patency of the treated site.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In CARDERA, combination therapy was only required to prevent radiological progression in ACPA-positive patients; corticosteroids only provided significant disease activity and physical health improvements in ACPA-positive disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first account of clozapine treatment in patients with ASPD and high psychopathy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with recurrent IVF embryo transfer failures after normal hysterosalpingography findings should also be reevaluated using hysteroscopy prior to further commencing IVF-embryo transfer cycles in order to enhance the clinical pregnancy rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has the potential to affect the interpretation of biopsy results, including suitability of patients for inclusion in active surveillance protocols.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that Mg may inhibit vascular calcification.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, data support that pleiotropic effects of ticagrelor beyond its potent antiplatelet effects could contribute to additional clinical benefits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by the Advanced Clinical Research Organization and  the Japan Breast Cancer Research Group; CREATE-X UMIN Clinical Trials Registry number, UMIN000000843 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Predictors of subsequent arrhythmic death after an AMI, useful on a per patient basis, remain an unmet need.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, TADS might be the preferred method for reinforcing orthodontic anchorage in patients who need maximum anchorage.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Automatic HNP scoring can correctly recommend CPAP treatment in most of more symptomatic patients with OSA suspicion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TKA patients were balanced over their feet and they appeared more cautious and more concerned about gait quality than moving quickly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, pulsed-wave Doppler may be used to monitor the success of SGB.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the resources needed to implement an intervention like this in clinical practice, based on these results, the continuation of usual care is recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A BNI for HH drinkers can be successfully developed for EPs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides initial evidence that IP can be used to alter high-calorie food preferences, which could promote healthier eating habits.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of malnutrition in Chinese hospitals was similar to that in European hospitals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results provide  a suitable basis for a broader interdisciplinary discussion of the patient-physician relationship and should be useful in generating hypotheses for  subsequent prospective studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMPLICATIONS FOR PRACTICE: This study demonstrated the clinical effectiveness and the feasibility of applying the MSM method to breast cancer survivors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The technique can be used within regular cognitive behavioural therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LDL-C levels\\xa0<25 or\\xa0<15 mg/dl on alirocumab were not associated with an increase in overall treatment-emergent adverse event rates or neurocognitive events, although cataract incidence appeared to be\\xa0increased\\xa0in the group achieving LDL-C levels\\xa0<25 mg/dl.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests a need to facilitate referral to more intensive long-term interventions for clients with risk factors identified by primary health care nurses.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No difference in nephrotoxicity was found between iopromide and iodixanol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because technology-based interventions such as TES have high fidelity, are inexpensive and scalable, and can be implemented in a wide variety of settings, they have the potential to greatly increase access to effective prevention programming.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, significant differences in the prolactin levels at 168 h after surgery imply that the stress response is better preserved in the MIE group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unsuspected cirrhosis is seen in 3.3% of young patients with CF, heterogeneous in 8.9%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The free-tracing method to measure antral cross-sectional area is equivalent to the two-diameter method.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Group 3\\xa0cm obtained a lower percentage of suboptimal results using EWL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The specific mechanisms underlying the association between AMD and LIPC require further investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Earplugs may be a useful instrument in the prevention of confusion or delirium.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EVL may be a good alternative to cyanoacrylate injection in treatment of bleeding junctional varices.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Residents were able to successfully self-assess using the 41 Orthopaedic Surgery milestones.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The model, validated by means of logistic regression and bootstrap analysis, contains the variables AGE, TC, and CA 19.9 (three of the original six) and has a level 4 over 5 according to the criteria of Justice et al. (multiple independent validations) Ann. Intern.Med.1999; 130: 515.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results demonstrate the utility of eQTL mapping in the identification of novel asthma genes and provide evidence for the importance of FADS2, NAGA, and F13A1 in the pathogenesis of asthma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hyperammonemic encephalopathy after Roux-en-Y gastric bypass surgery is a newly recognized, potentially fatal syndrome with diverse pathophysiologic mechanisms encompassing genetic and nongenetic causes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence that a sample of the U.S. general public prefers the aesthetics of the oval umbilicoplasty incision, which contrasted with the lack of preference identified within this focus group of plastic surgeons.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Heated humidification should be considered as part of an approach to patients who are troubled with nasal symptoms, once leak has been minimised.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with mild HF, CRT produced reverse LV remodelling accompanied by very low mortality and need for heart failure hospitalization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Liraglutide added to glimepiride was well tolerated and provided improved glycaemic control and favourable weight profile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Collectively, deciduous teeth submitted to PCR prevented pulp exposure and, consequently, more invasive treatments; otherwise, PCR yielded lower longevity for composite restoration compared to TCR, suggesting that PCR restorations need to be followed over time, especially when multi-surface restorations are involved.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies  are required to show whether the higher plasma levels of ezetimibe and its active metabolite in patients taking the 20-mg dose have any detrimental effects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These types of displays may be amenable to generation by software programs and have the potential to enhance information transfer in various settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tramadol hydrochloride can be a good alternative to local anesthetic agents and beneficial to support anesthesia during long operations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physical exercise, enough vegetable and fruit intake are positively associated with HRQOL of BCS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperatively, an additional 20.5% developed a psychiatric disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This nutrition assessment documented good status for folate, vitamin  B6, and vitamin B12 in the highly active women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using MI might be a novel approach to the problem of health professionals who smoke.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABBREVIATIONS: BMI = body mass index; CGM = continuous glucose monitoring; DKA =  diabetic ketoacidosis; HbA1c = glycated hemoglobin; PostP = postprandial; PreP =  preprandial; SMBG = self-monitored blood glucose; T1D = type 1 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a country with free access to health care, the socioeconomic factors such as middle age, low education, and low income were associated with nonattainment of goals for diabetes care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, close monitoring of blood sugar control is important to slow CKD progression, but long-term prospective cohorts are needed to gain better insights into the impact of QoC indicators on CKD progression.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggested that treatment of intermediate-risk prostate cancer with definitive dose-escalated EBRT alone resulted in acceptable outcomes, and it failed to show improved outcomes in patients who received short term ADT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endothelial dysfunction is associated with high FGF21 in HD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "FFM is an independent predictor of exercise capacity and rehospitalisation during 6 months.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this population, LBW infants are at a risk of delayed and incomplete immunization and therefore need attention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Almost two out of three primary care providers would like to continue six-monthly monitoring of well-controlled type 2 diabetes patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the PASE may not be sufficiently responsive to measure change in physical activity level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strengthening the child survival initiatives, namely universal child immunization, family planning and breast feeding - is strongly recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For this population, there is a need for more effective treatment than standard chemotherapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Calprotectin testing of young adults with suspected IBD in primary care accurately distinguishes IBD from functional gut disorder, even in patients with gastrointestinal alarm symptoms and reduces secondary care referrals and diagnostic healthcare costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therapists should therefore target self-focused attention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some of these risk factors appear to be linked to  systemic inflammation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether these established arterial hypertension risk factors are truly confounders of the HbA1c-arterial hypertension association or rather potentially antecedent factors requires .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrasonography may be appropriate when physical assessment is difficult, as in the case of obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Determining sarcopenia at the bedside was feasible in postoperative hip fracture patients by using grip strength, estimation of muscle mass by anthropometry and self-reported mobility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings provide information on the direction in which efforts for improving intervention should be directed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No association was found between body image and sexual performance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Teneligliptin was effective and well tolerated in Japanese T2DM patients with inadequate glycemic control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results indicated a significant association between Internet addiction and obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the absence of a clear advantage of one technique over the others, the decision regarding the preferred method to close the vaginal cuff in robotic-assisted total laparoscopic hysterectomy should be based on surgeons' preference and cost effectiveness.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the sinonasal region is an unfavorable site for rhabdomyosarcomas, in our series patients younger than 18 years and those with embryonal or botryoid subtypes responded very well to current multimodality treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aging and health impairments, such as arthritis and hearing difficulties, are risk factors for which accommodations and preventive strategies can be devised to prevent fall-related injuries on the farm.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The independent contribution of waist and hip circumference in opposite directions was intriguing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The efficacy of implementing such intervention in the scope of conventional TTA rehabilitation should be further studied.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chan-Chuang qigong exercise could be regarded as an adjunct measure in clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The promise of combining risk assessment, communication and management within one consultation was not realised.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have noted that the implication of C3435T variant on the risk of  breast cancer was ethnicity-dependent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high proportion of patients in Abuja have markers of DM and pre-diabetes at the time of TB diagnosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, T stage, baseline prostate-specific antigen level, and Gleason score were critical determinants of prostate-specific antigen failure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All patients with persistent, nonspecific musculoskeletal pain are at high risk for the consequences of unrecognized and untreated severe hypovitaminosis D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetic patients have not only a risk of contracting Legionella pneumonia, but also a risk of progression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ongoing effort should be devoted to staff education in proper sizing and fit, particularly for patients with high BMI.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that non-responders to statin therapy are more likely to actually be non-adherers, since they have more characteristics that are viewed as indicators of high self-perceived health and low disease awareness, possibly making the subjects less adherent to study medication.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The n-3 PUFA status may be monitored by means of the determination of whole blood AA/EPA ratio.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support a significant association between the high level of HDL-C, triglyceride and depression in large sample data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results suggest that the IL-33 rs7044343 T allele could be a susceptibility marker for premature CAD and central obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low predictability sentences predominated in the protocol for assessment of speech intelligibility used in this study, suggesting that these sentences can be used reliably for assessing intelligibility.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other areas that could be targeted in future initiatives in this field include access to screening in rural areas and removal of current barriers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Standard measurement scales failed to adequately reflect personality or mood changes subjectively perceived by patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, FCR is frequent among women, particularly when closer in time to primary surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of more than one assay may be needed for evaluation of immune response because live attenuated vaccines could effectively induce different kinds of responses.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This includes improvement of thyroid function and reduction of thyroid medication dosages.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding indicated that a specific implant size may be involved in mandibular bone preservation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have policy implications in that employer-/insurer-subsidized gym memberships may require interventions targeting other levels of change (e.g., physical or social/environmental) to foster sustainable fitness improvements.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests mannequins can be used to assess students' knowledge of the relevant case-specific PE without adverse effect.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A 10-15% reduction in  body weight is an appropriate target to achieve substantial improvement in ALT levels.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the effects were statistically significant, alterations were small.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study needs to be reproduced and adapted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Protein vaccines may be needed for high-risk adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because the benefits of DOT for adherence and viral load among HIV-infected methadone patients cease after DOT is stopped, methadone-based DOT should be considered a long-term intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduced salivary flow was found in the group assessed in the present research; however, this finding is not in accordance with the perception of xerostomia/dry mouth reported by the patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuing efforts are required to fully understand how the family and psychosocial environment interact with diabetes to impact on long-term health outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings demonstrate that oxygen extraction rate is the major factor in the difference between S(v)O(2) and S(cv)O(2).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Widening disparities were identified over time with key areas of concern including disproportionate, progressive increases in the burden of chronic conditions among women from rural and low-income communities and those with deliveries funded by Medicaid.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These  results should, however, be validated in a larger prospective study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Coinfection and superinfection of hepatitis D virus were found to be uncommon at Bir hospital, Nepal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, the clinical impact of the findings is most likely limited.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mid-pregnancy HbA1c level was associated with various adverse pregnancy outcomes in high-risk Taiwanese women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings could be important in facilitating adoption of shared decision-making tools into routine orthopaedic practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Female gender and rapid weight loss were major risk factors for postoperative cholelithiasis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BMI SDS and WC were reduced after 1.5 years of treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chest physical therapy as an adjunct to standard treatment does not hasten clinical resolution of children hospitalised with acute pneumonia and may prolong duration of coughing and rhonchi.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Risk factor differences may, in part, explain a previously found North-South divide in mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we would recommend to tailor interventions taking into account the ethnic background of the family.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the increasing use of handheld computers for electronic data collection in clinical research, these devices should be used with caution.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum fructosamine was increased in women with RPL compared with controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of exergaming in community pediatric weight management did not improve weight status at the end of programming, and study implementation was limited by small sample and missing data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Female, older age, long disease course, less education and high BMI are all factors caused reduced QOL and patients with these factors should be given more psychological support.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests that LTD should be considered when making the decision of which IUD model to use.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New strategies are needed to improve the tolerance.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results suggest that formal involvement of a support person (e.g. family member/friend) and referring women to ongoing, community-based services to maintain patient-perceived accountability may be particularly useful strategies for future weight loss intervention trials targeting women with breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research on cardiovascular events from this prospective study may confirm the association.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The drinking habits among adults during midlife affect the atherosclerotic process and sustained heavy drinking is associated with an increased cIMT compared to stable moderate drinkers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Level III Treatment Study in a Case Control Manner.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of exercise training may be helpful for PMV patients to improve hospitalization outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant differences were found among patients visiting the cancer center versus the mobile mammography van.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given these economic results in tandem with the clinical, operational and patient-related benefits, the wider implementation and evaluation of similar schemes should be considered.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Single-agent CC is simple, cheap and may be used as treatment for hypogonadism when maintenance of fertility is desired.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings from this study can provide useful information to nurses and other health care providers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results highlight the importance of early intervention in young at-risk subjects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this increase was not associated with weight loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Simvastatin-related reductions in CSF p-tau181 concentrations may be modulated by LDL cholesterol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest that distressed prostate cancer patients may benefit from additional support managing the emotional aspects of medical decisions and weighing immediate versus delayed outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term ketogenic diet treatment stimulates liver parenchymal injury, hepatic steatosis and gallstone formation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Utilisation of PPI was found to be of relatively high prevalence and significantly associated with parameters of nutritional risk screening.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Left ventricular ejection fraction and Syntax score were independent predictors of unplanned cardiac RHs and identified patient subgroups in need for improved secondary prevention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The epidemiological data on the effect of the Opisthorchis felineus invasion on mechanisms of food sensitization in children were obtained.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hormone therapy use was strongly associated with risk of luminal-like breast cancer, and less so  with risk of HER2-positive or triple-negative cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypomotility of the esophageal body is the most common dysmotility, especially from the absence of significant waves.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Association of socioeconomic factors with pharmacotherapy was inconsistent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improved temporal resolution obviates the need for heart rate control.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher serum cholesterol levels are associated with lower AVG failure risk over a 1000-day period, which probably corresponds to the worse disease status of the patients with lower cholesterol values.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of this pilot trial justify a larger study to determine whether the result is more generally applicable to a broader population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specific trajectories were associated with greater BMI and waist circumference during adulthood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore; policies, strategies, and programs targeting people living with HIV should consider psychosocial factors that can impact nutritional status of people living with HIV enrolled on  ART.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Open transcrease approach is recommended in absence of lid crease whereas closed approach is better used in cases with preserved crease due to its superior functional outcome.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Before advising any COPD screening, its costs and its real possibility of affecting active smokers (the sole preventive possibility) should be carefully assessed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term intervention-effect was not observed in the postpartum period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Registration number: ChiCTR-TRC-14004395 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite routine clinical use of ES devices, knowledge degrades overtime, suggesting the need for ongoing formal educational activities to reinforce curricular objectives.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABBREVIATIONS: ADA = American Diabetes Association CRP = C-reactive protein DD =  definite diabetes FPG = fasting plasma glucose HbA1c = glycosylated hemoglobin MENA = Middle-East North Africa ND = no diabetes PD = probable diabetes RD = at risk of diabetes T2D = type 2 diabetes mellitus TSH = thyroid-stimulating hormone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Systemic use of doxycycline or metronidazole plus amoxicillin as an adjunct to conventional therapy may be used for the treatment of patients with LAP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial  was registered at clinicaltrials.gov as NCT02045784.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adapting Housing First with anti-racism/anti-oppression principles offers a promising approach to serving the diverse needs of homeless people from ethno-racial groups and strengthening the service systems developed to support them.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The underlying mechanisms related to occupational prestige as a predictor of work survival should be investigated in order to develop interventions to reduce the risk of work disability.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, for sthenia syndromes such as Qi stagnation syndrome (QSS), heart blood stasis syndrome (HBSS), and CCS, there was no obvious difference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only a few components of the training were actually applied after the training, and there is still ample room for improvement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study has found that inappropriate infant feeding; nutritional  information gap and lack of toilet facility as significant predictors of malnutrition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study provides empirical evidence to support the effectiveness of using therapeutic play intervention and the importance of parental involvement in the psychoeducational preparation of children for surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Restorations in group B performed worse (P<.05) in terms of esthetic (cavosurface marginal discoloration) and functional (marginal integrity) parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Grounding could become important for relaxation, health maintenance and disease prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Severe  maternal morbidity may be higher in women who require a cesarean delivery after labor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There continues to be large variation in margin policy and re-excision rates across units.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings lend support to the demand that the offer of colonoscopic screening should be extended at least to men aged 50 and above.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results provide support for current recommendations for traditional family style meal service in preschool settings.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No clinical signs of hypoperfusion were noted with induced hypotension, and infants\\xe2\\x89\\xa412 months old need significantly more propofol per kilogram for procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research might investigate how the healthfulness of the child-care environment can be improved by counseling providers on nutrition and PA strategies to prevent obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings show the importance of a culture sensitive adaptation of PIM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The LiFE programme provides an alternative to traditional exercise to consider for fall prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There appeared to be three distinct patterns of prior presentations in those patients admitted with a diagnosis of bipolar disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consideration of undiagnosed OSA is recommended for appropriate pre-procedure risk stratification.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main clinical relevance of this study is that the impact of the choice of short or long-segment treatment on postoperative sexual function and life quality should be considered by surgeons when performing posterior fixation after thoracolumbar junction burst fractures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, further studies are still needed to provide more evidence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although we could not determine the causality, visceral adiposity may be associated with the risk of CRC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genetic susceptibility appears to be more preponderant in individuals who meet both the modified 99WHO  and the IADPSG GDM diagnostic criteria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed to explore the reasons for this barrier to misoprostol availability.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sophisticated image analysis techniques can be used in developing countries to quantify PCO.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications of  higher concentrations of \u221a\u00e8\u201a\u00c4\u221e-6 fatty acids in the colostrum of women with GDM have  yet to be determined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduction of CV diseases is mediated by the pleiotropic effects of weight loss through surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is warranted to determine the mechanisms and consequences of this potential effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that higher HRQOL and exercise have both been associated with overall survival in women diagnosed with ovarian cancer, oncologists and primary care providers should recommend and refer women diagnosed with ovarian cancer to clinic- or community-based exercise programs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It support's a contribution of platelet to the vascular occlusion that underlies much of the morbidity in the disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there was not any harm or adverse event for using aromatherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical application of 0.5% nifedipine ointment represents a new, promising, easily handled, effective alternative to lateral internal sphincterotomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "OSI correlates significantly with OI in infants with HRF.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LAIV could therefore be used as an experimental tool to elucidate the dynamics of transmission of nasopharyngeal bacteria.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Within the framework of inpatient psychosomatic treatment involving a psychotherapeutic treatment setting, substitution facilitates weight gain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Male sex, sports, injuries \u221a\u00a2\u201a\u00c4\u221e\u00ac\u00a76 weeks from surgery, and preoperative episodes of instability  predicted medial meniscal tears and management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nurses should assess patient decision-making styles to ensure maximum patient involvement in the decision-making process based on personal desires regardless of age.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PBL mode of teaching integrated dental alveolar surgery may improve preparedness for clinical practice and help undergraduates to develop the desire to collaborate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LIMITATIONS: There was an unequal distribution in numbers of subjects between study groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the importance of patients' preference for treatment planning and success, the ODT formulation should be routinely considered as a treatment option.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MR imaging should be primarily performed in the preoperative detection of prostate cancer.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore this position should be used cautiously in higher-risk patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The latter suggests that children on HAART require nutritional supplementation, especially during the early initiation of HAART.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with the studied cephalosporins during pregnancy does not seem to present a detectable teratogenic risk to the fetus.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of founder effects, registry-based prevalence studies probably need to be very large and they should also include prospectively collected phenotypes  and extensive mutation screening to establish the true prevalence of MODY.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest a safe, economical method to improve fitness and maintain erythrocytes in women during radiation treatment of breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the sample studied, no association was found between fetal growth restriction and changes in cardiovascular risk factors in adolescents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, combined treatment may become a more effective therapeutic option for PCOS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Investigators should be cautious when estimating consent rates.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This work has important policy implications for public health, given the continuous nature of the BMI-IHD association and the modifiable nature of BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ISRCTN13981084 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Legionella pneumonia did not always present as severe pneumonia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physicians are responsive to receiving notification of their patients' limited HL, and patients support the potential utility of HL screening.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The issues of randomisation, targeting and responders in are problematised and discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nurses should understand the complex factors that influence a womans decision-making style to  best help with the decision.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Closer follow-up with patients who evidence presurgical psychological factors, both before and after surgery, may help improve outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings support NAC as a pharmacotherapy to complement psychosocial treatment for cannabis dependence in adolescents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ultrafast protocol achieved at least comparable image quality and high diagnostic concordance compared to the conventional protocol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular the P3 component is an indicator for patients at risk for reinfarction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Identification of the correct anatomical landmark for needle thoracocentesis can be performed with instructions provided via VT because a dispatcher can monitor every step and provide correct instructions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results indicate that the RBF may decrease in patients with type 2 diabetes without retinopathy and in those with mild retinopathy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show that retinal photocoagulation in patients with branch vein occlusion has a vasoconstrictive effect on occluded veins.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GTF is well tolerated and helps with catch-up growth and puberty.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The submucosal injection of dexamethasone or triamcinolone acetonide might be an effective treatment for postoperative discomfort occurring following impacted mandibular third molar surgery, and triamcinolone acetonide could be applied as an alternative to dexamethasone.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tobacco smoking cessation was associated with new-onset GERS among those who gained weight upon quitting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aggressive treatment of lipid abnormalities in these patients may be warranted.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They must also determine whether TFA from ruminant fat in currently consumed amounts represent limited cardiovascular risk  that is balanced by the nutritional benefits of dairy products.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of this post-hoc analysis suggest that LEV may be a suitable option for initial monotherapy for patients aged\\xe2\\x80\\x89\\xe2\\x89\\xa5\\xe2\\x80\\x8960\\xc2\\xa0years with newly diagnosed epilepsy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No deterioration was observed in psychological assessment or quality of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CTLA4 might contribute to the humoral immune response to GAD in newly diagnosed subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with thoracic curves should be counseled accordingly.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Risk factors for revision surgery after SLAP repair include age >40 years, female sex, obesity, smoking, and diagnosis of biceps tendinitis or long head of the biceps tearing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study sets the foundation for larger studies to evaluate the  superiority of TNP over traditional dressings in high-risk foot wounds.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the need for meticulous nutritional evaluation and management in these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The interaction of green tea consumption and non obesity have reduced risk of lacunar infarction, but not after adjustment for age, diet factors, vascular risk factors and atherogenic index.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C-reactive protein provided additive  prognostic information over standard lipid measures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ACCHSs may need assistance to achieve desirable levels of testing.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The DEBELLUM trial confirmed the ability of paclitaxel-eluting balloons to reduce restenosis vs. conventional balloons at 6 months after treatment of multilevel (femoropopliteal and BTK) arterial disease in patients affected by claudication and CLI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Any type of familial support including verbally encouraging, watching, and involving had effects on reducing leisure-time sedentary behaviours.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is therefore important to use cleaned and sterilised customised abutments in patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AMTSL should be recommended, regardless of whether pregnant women received oxytocin during the first and second stages of labor.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since presence of E6/E7 mRNA was common in multiple infections regardless of histology, multiple infection could be a clinically important finding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This differential change may represent an initial sign of an evolving lower limb muscle asymmetry, which may play a role in the development of knee OA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SLNB is a viable technique in patients with breast cancer undergoing  NE/CT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide novel insights into the pathogenesis of pediatric sepsis and promote the generation of diagnostic gene sets.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A wide variety of system designs, facilities, and personnel configurations are used to provide emergency medical care for spectators attending NFL games.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, our findings may be particularly useful to others interested in understanding the vascular dynamics of the cerebral vessels and to researchers running clinical trials related to hormone replacement therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The original dissecting balloon employed at our institution is easy and fast and offers a valid option for the proper dissection of the retroperitoneal space.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to confirm whether known loci have a consistent effect across ethnic groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov NCT00966615.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Micronutrient fortification may be necessary, and small fish may be an affordable alternative to milk to improve complementary foods.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These patients can be treated with lithotripsy safely.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This technique appears safe for use through 27 weeks' gestation; further investigation is encouraged.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the cause and effect relationship between iron deficiency state and goitre requires further elucidation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, ivabradine can be a potential treatment to improve ventricular control in patients with non-paroxysmal AF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42016037937.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings require further validation in the ongoing prospective ODYSSEY OUTCOMES trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that the work environment as perceived by staff is associated with the extent to which staff perceive the care as being person-centred in residential aged care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TWILIGHT is the largest study to date that is specifically designed and powered to demonstrate reductions in bleeding with ticagrelor monotherapy versus ticagrelor plus ASA beyond 3 months post-procedure in a high-risk PCI population treated with DES.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be a potential strategy to improve fat absorption, and thus growth and development in infants fed with PHM; however, its gastrointestinal tolerance needs to be investigated further.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ocular injuries are common when olives were harvested manually or with sticks.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In virologically suppressed individuals with HIV infection, atorvastatin did not significantly decrease levels of soluble or cellular biomarkers of immune activation and inflammation but resulted in robust reductions in LDL cholesterol, oxLDL, and lipoprotein-associated phospholipase A2, biomarkers associated with cardiovascular risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A peak GH of 11.5 microg/liter or  less and IGF-I SDS -0.28 or less were highly predictive of delayed deterioration  of GH secretion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hypothesis that resilience might play a role in the outcome has not been confirmed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inhaled formoterol can thus be used by asthmatic athletes in sports under extreme conditions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research may identify relationships between disease-related weight loss and currently used prognostic factors in MM, further  defining the role of this clinical factor in prognostic stratification.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies could inform national guidance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future prospective  studies should include direct measures of aspirin compliance, gestational age at  initiation, and explore the influence of race and ethnicity on the efficacy of this primary prevention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High levels of anti-interferon beta (IFNbeta) antibodies, which result in diminished bioactivity, are correlated with reduced therapeutic efficacy of IFNbeta.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The role of serum resistin in response to inflammation caused by endometriosis or chronic pelvic infection, both of which are major causes of female infertility, should be examined in a further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that the association between H. pylori infection and serum HDL could be transmitted through IL-6.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides support for the use of a scale-based method for quantifying cannabis use in grams.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to HbA1c criteria our diabetes algorithm and diabetes predictor score had a better correlation with OGTT criteria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum bilirubin concentration is inversely and independently associated and inversely correlated with the prevalence of DR and may predict progression of DR over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, TP53 mutation analysis should be incorporated into the evaluation of patients with CLL before treatment initiation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest romantic relationship stress is associated with greater suicide risk, and have clinical implications for suicide prevention and intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although amoxicillin is empirically dosed twice daily, amoxicillin should be dosed at least three times daily in amoxicillin-based triple therapies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Through gratitude diary appears a very straightforward intervention that could be developed as an adjunctive strategy for suicidal patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daily tracking of dyspnoea symptoms may be an important adjunct to daily weight to prevent hospitalization.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Playful interventions may improve knowledge and physical activity levels in children and, when combined with other strategies, may be beneficial to prevent child obesity and improve self-care.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Discussion focuses on the possible role of locus of attention in motor learning.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It could be a therapeutic option for appropriate morbidly obese patients with NASH who do not respond to lifestyle modifications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The group patients with an increase of hand eczema tended to have a higher mean total IgE level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At short term, unfavourable effects may occur.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the contrary, older inhabitants living with someone tended to participate in the physical checkup examination for social interchange when they were frequently alone in the household.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With regard to digital photography in suspected skin cancer, it is unlikely that this approach can dramatically reduce the need for conventional clinical consultations, whilst still maintaining clinical safety.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of the present study should be considered preliminary and interpreted with caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, attenuated hypocholesterolemia (ISS \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022 20-&-TC \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022 90 mg/dL) represents a unique response that can occur with critical injury.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of routine upper gastrointestinal contrast studies for early  detection of staple line leaks has low sensitivity and is costly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intervention was specifically designed for an African context and has the potential to benefit large numbers of children, if it can be widely implemented.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We confirmed a reduction in critical events, liver-related or not, in\\xa0a\\xa0prospective study of patients with HCV infection and compensated cirrhosis included in the CirVir cohort who achieved an SVR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BE is one of the most severe complications of LAGB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are no gender differences in achieving lipid goals, and age is a predictor of adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Usage of prospective randomized open label endpoint evaluation design should be carefully considered when well-known treatments are compared with rather new ones and especially in segments where patients could be more vulnerable, as in the elderly.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with DM and chronic angina with incomplete revascularization after percutaneous coronary intervention, ranolazines effect on glucose control and angina at 6 months was proportionate to baseline HbA1c, but the\\xa0effect on angina dissipated by 12 months.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prolonging periods of elevated physical activity in the afternoon while respecting individual daily routine and commitments could be one option for facilitating the integration of physical activity and for making it a habit in older adults' daily lives.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The one minute sit-to-stand test is a valuable alternative to 6MWT to estimate functional exercise performance in COPD patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In agreement with the notion that local anesthesia may be beneficial for cancer therapy, lidocaine has a protective effect against breast cancer cells in experimental studies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A large and progressive increase in the macrophage-derived neurotoxin quinolinic acid is seen following severe TBI in children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results have revealed the higher plasma level of lipids in psoriatic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Steno-occlusive ischemic changes in moyamoya disease might cause suppression of neurophysiologic activity, and the present results provide insight into the potential neuromodulatory role of revascularization surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients sedated with midazolam may have an increased need for active airway management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, for relative infarct size assessment either method for calculation of total myocardial mass can be used.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A better understanding of the natural history of patients sent to SNFs after hospitalization and risk factors for failure to return to home, readmission, and death should help identify opportunities for interventions to improved outcome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The newly introduced nano-filled composite materials can potentially be used to bond orthodontic brackets to teeth if its consistency can be more flowable to readily adhere to the bracket base.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study failed to comprehensively capture CVD risk factors in women with breast cancer because of missing data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significance of protease inhibitor use was limited to studies using the strictest diagnostic criteria for GDM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, there is a need to define standard dietary reference intake to determine inadequate iron intakes in the Spanish population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After total thyroidectomy, increases in weight and serum cholesterol  were observed in the eSCH group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mitii\\xe2\\x84\\xa2, in its current form, was not shown to improve EF in children with ABI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because low general nutrition knowledge may be detrimental to dietary intake, health, and operational readiness in military personnel, nutrition education programs particularly targeted at SOLs and CKs seem warranted.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Men drinking on an empty stomach should know BAC will vary depending on beverage type and the rate and amount of EtOH.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with GDM have lower circulating levels of SHBG than normal glucose tolerance pregnant women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the risk of AVN in severe stable SCFE (5.4%) must still be balanced with the functional outcomes of potential future FAI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hysteresis phenomenon should not be neglected when dedicated QT studies are performed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PFASs exposure in obese children may play a role in adverse skeletal  and cardiovascular risk profiles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the study show that in the course of HIV infection overweight/obesity affected men and women admitted with normal weight, although a greater proportion of women progressed to obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both of the tested analgesic regimes can be used safely and effectively for postoperative pain relief in patients after spine surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inflammation remained present throughout a 2-year follow-up in patients with an initial CRP higher than 5 mg/L.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Either NIV or CPAP are recommended in patients with CPE in the ICU.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinician judgement and Centor score are inadequate tools for clinical decision-making for children presenting with sore throat.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A working collaboration between disciplines and a specialized wound department are central in achieving better results.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Younger age harbours aggressive clinicopathologic characteristics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HS provides a complete hemobiliary stasis and is a safe alternative to stander clip of cystic duct and artery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is fungal colonization of cholesteatoma which is pathogenic and can cause persistent otorrhoea.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Circumferences and skinfolds demonstrated less reliability and lost precision over time, probably as a result of insufficient supervision over the entire length of the study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Quantifying somnolence longitudinally is important in clinical trials and practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study supports the hypothesis of a significant short-term risk of T2D in RA patients and of a close associations between uncontrolled disease activity and glucose metabolism derangement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A brief telephone-based intervention with a focused message delivered by a registered dietitian is a feasible approach for encouraging targeted dietary changes, such as an increase in soy intake among peri- and postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is a easy method of four lattice to measure change of weight-bearing in KOA patients after treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ischemic brain lesions are frequently observed in CABG surgery patients but are neither associated with clinically relevant neurological complications nor with ECC set-up and intraoperative heparin dosage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed associations in this study were modest.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to find individuals with impaired glucose tolerance for implementation of lifestyle changes in primary care should therefore be developed further.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Point-of-care tests can be used to assess the degree of hypercoagulability and hyperaggregability in  obese patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study suggests that this iontophoresis technique for delivery of corticosteroid may be considered a treatment option for patients with lateral epicondylitis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results may have important implications for families as well as for health care costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interactive multiple choice tests may provide an alternative to written tests, especially when considering time expenditure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tramadol given 30\\xe2\\x80\\x89min before patch application should be considered as an alternative pretreatment option in patients receiving capsaicin patch treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No age dependence was noted for pulmonary toxicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results provide evidence that RPT and COPE both led to significant reductions in PTSD, providing further support that exposure-based techniques tailored for SUD can be conducted without jeopardizing PTSD or SUD outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-mass enhancement with an adjacent landmark is more likely to have a US correlate compared to non-mass enhancement without an adjacent landmark.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The electrodiagnostic examination can be successfully masked.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLS provides a valid option for the treatment of recalcitrant erythromelalgia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas the survival advantage of high BMI is consistent across all  racial/ethnic groups, black maintenance HD patients had the strongest and most consistent association of higher BMI with improved survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ursodeoxycholic acid significantly reduces pruritus, but the size of the benefit may be too small for most doctors to recommend it, or for most women to want to take it.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, serious attempt  should be made to correct risk factors before an ablation therapy is proposed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "L-trps effect on GLP-1 secretion is only minor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is the first to reveal significant associations between SSRI use and metabolic abnormalities in patients with schizophrenia or bipolar disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study depicts rising cases of hypertension and an alarming rate  of pre-hypertension among the working population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although energy intake was increased in the HCDE group compared to the control group, further study of the HCDE is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because these concentrations are not commercially available, proceduralists must dilute their contrast for such procedures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant positive correlations exist between body mass and lateral abdominal muscle thickness in adolescent athletes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improved disease-related knowledge may need to be combined with other target variables to induce desired effects on depression, anxiety and quality of life of family members.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is important in the discussion of who to perform MR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that the overall living conditions of the built environment may be relevant to social inclusion for persons with physical disabilities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrasound training as an adjunct to traditional means of teaching abdominal examination improves students' physical examination technique after students have acquired skills with basic examination manoeuvres.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was also a link between slow-wave sleep duration and insulin resistance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Together with mean HbA1c, baseline urine albumin-to-creatinine ratio and presence of hypertension, accurate 3-year new-onset albuminuria prediction may be possible.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Novo Nordisk and others; DEVOTE ClinicalTrials.gov number, NCT01959529 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the overall Women's Health Initiative Clinical Trial cohort and within each treatment group, women with younger menopause age (<40 y) had a higher risk of any fracture than women reporting older menopause ages.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mucous fistula refeeding is safe and can decrease risk of anastomotic complication and parental nutrition related cholestasis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While people attending sexual health clinics may want to achieve better sexual health, attempts to reduce alcohol consumption may not be seen by them as a necessary means of trying to achieve this aim.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results confirm the need of a multidisciplinary approach to patients with vertigo.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite some methodological limitations, results showed that MCT proved to be a promising psychotherapeutic alternative to the well-established ERP in the treatment of pediatric OCD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with an RBC DHA+EPA status of 5.5g% need 750 and 1000mg DHA+EPA/day to reach 8g% RBC DHA+EPA at the pregnancy end and 1g% mature milk DHA+EPA, respectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its use in daily practice is suggested.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results have important implications for preventing violence and associated physical and mental health problems.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Differences in the frequency of pretreatment hematological abnormalities could have important implications for the choice of antiretroviral regimen in resource-constrained settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In diabetic patients with DME or PDR, the intravitreal levels of permeability and proangiogenic factors Ang-2 and VEGF were lower in simvastatin-treated than in those without statin medication.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Negative perceptions about the use of a facilitator should be addressed before the intervention is implemented, in order to ensure its effectiveness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Volume guaranteed ventilation combined with PSV may be a convenient method for preterm infants with RDS in terms of reducing postextubation atelectasis and the need for reintubation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the reasonable anesthesia administration, the adverse response can be controlled effectively.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports the potential of CXCR2 antagonists as a treatment option for diseases in which neutrophils play a pathological role.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CTRP3 may serve as a novel biomarker for DR severity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Molecular tests are likely to be cost-effective, but an optimal test is yet to be identified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of 100 mg of tramadol to 7.5 mg/ml of ropivacaine, for axillary brachial plexus block, does not prolong the duration of motor and sensory block and analgesia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both BCS and mastectomy are feasible in primary and secondary angiosarcoma if R0 can be achieved.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These cardiac biomarker data provide support for the beneficial cardiovascular\\xa0effect of sodium glucose co-transporter 2 inhibitors in T2DM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings are inconclusive as to the possible effect of metformin on the prognosis of endometrioid EC in women with T2D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intake of TFAs is high in Iranian homes and contributes to a sizeable proportion of CHD events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has significant cost implications for the office urologist.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential disease-modifying effects of simvastatin on CSF phospho-tau should be further investigated in persons with hypercholesterolemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Varying degrees of cytologic atypia and possible cell type differences from the primary counterpart or metastatic melanoma occurring elsewhere are additional sources of diagnostic challenges, especially in the metastatic setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed that it is safe and technically feasible to complete a volumetric MR-HIFU ablation with DISC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a large-scale primary prevention cohort, plasma levels of PCSK9 measured at baseline did not predict future cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To treat and care for elderly hip-fractured patients, specific interventions need to target those who are malnourished or at risk of malnutrition to decrease their risk for cognitive impairment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This meta-analysis indicated that the TNF-alpha-238G/A polymorphism is not associated with breast cancer risk in the overall population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the 10-year follow up QoL of the participants deteriorated significantly and more participants had progressed to higher CPG III and CPG IV.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with insulin lispro resulted in weight gain and an increased risk of hypoglycemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the very large effects on reductions in dental plaque and gingivitis, promoting dental care competence in an autonomy-supportive way, relative to standard care, has important practical implications for dental treatment, home care, and health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Infection and inflammation were linked to evidence of GH resistance, whereas levels of GH, IGF-1, and IGFBP-3 were associated with growth indices independent of hsCRP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, caution should be exercised when using unidimensional and 2D measurements of LA size.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MT significantly lowered patient anxiety and distress during the simulation procedure on the basis of the STAI-S questionnaire and SDT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the SBP achieved in the felodipine group was below the recommended goal of less than 140 mmHg, and SBP in the placebo group was slightly above that level, FEVER provides the required evidence in support of the guidelines recommended goal, even for a hypertensive population not entirely consisting of patients with diabetes or previous cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This cohort study demonstrates the achievement of the HbA1c clinical target (\u221a\u00a2\u201a\u00c4\u221e\u00ac\u00a77%) is the only QoC indicator protective against progression of CKD stage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present meta-analysis suggests that insulin therapy may increase the risk of CRC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Upgrading GG from biopsy to RP may have consequences on clinical outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Options for enhancing clinical outcome include the use of multifaceted collaborative care interventions in the pediatric practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sequential compared with the concurrent administration of anthracyclines and taxanes is associated with a non-significant but possibly clinically meaningful improvement in DFS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research could investigate how to  improve engagement at initial invitations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that significant improvements in outcomes are achieved with higher MPR thresholds than commonly targeted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPAR\u221a\u00e9\u00ac\u00a5/STAT3 pathway.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results provide some support for the notion that dosage is an important consideration in relation to effectiveness; however, the cost-benefit balance does not support the clinical utility of olanzapine in treating alcohol dependence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We would postulate that SMS could affect peoples adherence to preventive programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study found an association between tuberculosis and IR development in newly diagnosed pulmonary tuberculosis patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest a protective relationship between IL1R1rs2287047 (AA+AG) and PCF and provide further evidence supporting exercise as a potential intervention for poorer PCF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Decreased bone density is common in children with SLE and other systemic rheumatic diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Age, female sex, BMI, non-HDL cholesterol, and polyps are independent determinants for gallstone formation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Novel RCT designs may provide information that can be used to optimize behavioral pain interventions to be adaptive, better meet patients' needs, reduce barriers, and match with clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we think that a correct information protocol should be integrated into the patient's preoperative preparation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Acupoints has its own specific brain activated areas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides cross-sectional data confirming the existence of the IRS in native Hawaiians.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support the routine use of this simple and cheap alternative method of skin disinfection before epidural anaesthesia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its highly accurate predictions should improve patient and physician understanding of survival and may prove a useful tool in post-infarct risk stratification.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In normal-weight children with OSA or PS, behavior and quality-of-life scores are similar regardless of the severity of the sleep disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reductions in LDL-C were greater among women randomized to both calcium+vitamin D and hormone therapy than for those randomized to either intervention alone or to placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of this pilot study add to the growing literature on the use of this technology for health education in low-income Latino immigrants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If MGS implantation is noninferior to a strategy of MT pretreatment followed by BMS deployment, it will lend support to the use of this treatment as another possible option for STEMI patients undergoing PCI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data clearly show increased nitric oxide production in certain temporomandibular disorders and suggest that nitric oxide may play a role in the pathogenesis of synovitis and degenerative changes of cartilaginous tissue and bone of the temporomandibular joint.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As predicted by the social cognitive processing theory, cognitive processing mediated the relationship between social constraints and depressive symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For a laboratory-guided transfusion protocol, massive transfusion protocols should be in place with faster turnaround time for coagulation tests.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moderate-sized (anterior) pneumothoraces may also be successfully managed without initial placement of a chest tube if the patient is not to undergo positive pressure ventilation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tarsal conjunctival response should be also considered in the context of the clinical performance of MPDs at the ocular surface.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reliance on T2 signal as a benign feature may be misleading, because one-third of malignancies had T2 signal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a phase 2B randomized trial of patients with moderate to severe DG, relamorelin significantly reduced core symptoms of DG and overall composite score compared with placebo, accelerated GE, and was generally safe and well tolerated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is supported by higher vWF expression in right atrial tissue in ischaemic patients, who developed post-surgical AF.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings contribute to the growing body of literature exploring psychosocial factors in T1DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These abnormalities are not consistently present in the follow-up studies and not related to the glycosylated haemoglobin and fructosamine.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 500-mL WDT may provide an alternative for patients who are unable to tolerate drinking 1000 mL of water.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Expressed lipid peroxidation activity is more physiological in andropause than in menopause.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings demonstrate that older adults contact more obstacles while walking with their attention divided when wearing multifocal glasses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dexmedetomidine is a useful adjunct to propofol for elective cardioversion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies designed to enhance supervisor transformational leadership have the potential to facilitate implementation efforts by promoting a strong climate for EBPI and positive provider attitudes toward adoption and use of EBP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the effects on ultrafiltration and fluid accumulation disappear with time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, pathogen burden does not appear to mediate SES differences in cardiovascular risk profiles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incorporation of this signature in prospective studies may help to stratify risk of early stage TNBC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data highlight that appropriate caution should be exercised not to extrapolate the positive effect of improved LVEF to the elimination of arrhythmic events.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SREMT may be recommended for use in rheumatological care as a technique that enhances the efficiency of performed therapy and medical rehabilitative measures in inflammatory and degenerative rheumatic diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Detection and treatment of secondary lipid targets such as high TG and low HDL-C levels may be important for the prevention of cardiovascular diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions that increase screening uptake may also increase subsequent engagement with information.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: UKCTOCS is registered as an International Standard Randomised Controlled Trial, number ISRCTN22488978 .Registered 06/04/2000.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ILC rarely presented as dense masses but frequently demonstrated architectural distortion on DBT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results support the construct validity and reliability of the Three-Factor Eating Questionnaire-R21 among males and highlight the importance of taking psychological factors into account in the prevention of obesity. Orv Hetil.2017; 158(37): 1469-1477.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its potential for treating gastroparesis may be explored, and a larger trial is required to draw definitive conclusions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of rosuvastatin 10mg/ezetimibe 10mg was an effectively alternative therapy superior to rosuvastatin 20mg or 10mg with a greater effect on lowering LDL-C and a lower incidence of drug-related adverse events in Chinese patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the fact that the present work shares some limitations mainly because of its cross-sectional design, the classification and regression tree approach has clearly demonstrated the interrelation between nutritional services and the health care system towards achieving benefits among the elders  quality of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings and limitations of this study should be taken into account in the planning of future clinical trials with NMDAR modulators in depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The STAMP may be an alternative method for assessing nutritional status in Chinese children with SCI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with DFU, the WIfI classification system correlated well with wound healing but was not associated with risk of major amputation at 1\\xa0year.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exclusive olive oil consumption was associated with lower risk of coronary artery disease, even after adjusting for adoption of an overall healthy  dietary pattern such as the Mediterranean diet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This supports a potential additive benefit of statins in the inflammatory state of ACS and reaffirms the clinical importance of statin therapy for coronary atherosclerosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutrition intervention is needed to increase awareness of the health benefits of cereal foods, particularly whole-grains, and to address barriers to incorporating them daily.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The WASP approach substantially reduced unnecessary use of antibiotics in children with AOM seen in an emergency department and may be an alternative to routine use of antimicrobials for treatment of such children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results could have implications for both clinical practice and clinical trial design.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intervention holds the potential to positively affect understanding and production of syntax and semantic features, such as prepositions and conjunctions, in young children with weak oral language skills.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results indicate that transperineal ultrasound assessment could be preferred to digital examination for the evaluation of progression of labor during this phase.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Robotic surgery may offer particular advantages in obese patients with no conversions and no wound complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modified BPTB allograft was recommended as an ideal graft option for the SB ACL reconstruction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MIRACLE I results suggest that Embozene TANDEM microspheres loaded with doxorubicin can provide good local tumor control in a heterogeneous group of patients with locally untreatable HCC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be applied discriminatively depending on the actual condition of patients and the aim of treatment in clinic.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eating behavior should be evaluated and followed before and during lifestyle interventions in order to support the change, e.g. by finding methods to control eating at risk situations and strengthening motivation and tolerance to problems.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In these situations, vinegar attenuated PPG by 20% compared to placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The general use of such treatment during lower respiratory tract infection with respiratory syncytial virus should not be advocated.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to address victimization, PTSD, and sexual risk in young women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed reduction of specific leucocyte subsets could create a microenvironment which is unfavourable for an appropriate placentation and could thereby be involved in the development of preeclamptic symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low-dose atorvastatin does not have a significant influence on cooling down inflammation in ACS, and MCP-1 can be used as an early indicator of statin anti-inflammatory activity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Faster aspart improved 1-h PPG with no differences in 2-4-h PPG versus IAsp.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TTE derived from ultrafast TWIST acquisitions is a valuable parameter that allows robust differentiation between malignant and benign breast  lesions with high accuracy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efforts to reduce these adverse events should become a research priority.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IgE M. furfur levels are strongly correlated with the severity of the disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity is increasingly prevalent and associated with a high incidence of co-morbidity and complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is imperative that patients receiving oral chemotherapy are supported with such programs, particularly during initial treatment cycles, to improve their treatment and symptom experiences.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Appropriate case selection is of primary importance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanism and clinical applicability of such observations need to be explored further.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings demonstrate that disclosing genetic information for personalized nutrition results in greater changes in intake for some dietary components compared to general population-based dietary advice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Older age, white race, and recurrence predicted testing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Girls with T1DM were more prone to thyroid disease, particularly hypothyroidism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may result in a significant reduction in the burden of testing on both patients and testing facility staff and resources.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may support the need of critically revising the concept of isolated diastolic dysfunction in these patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effective and efficient interventions that target children with obesity are necessary and could work in synergy with population-level prevention strategies to accelerate progress in reducing obesity prevalence.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation Both walking and strengthening exercises are effective means of improving pain in patients with knee osteoarthritis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The distribution of causal microorganisms, the case fatality rate, and the incidence rate of endocarditis are age related.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypercoagulability also correlated with inflammatory markers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study findings showed that oral DHEA administration in hypoadrenal women results in an unfavorable lipoprotein profile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Older adults with DM appear to perform poorly on an ambulatory measure of multitasking.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The instability in clinically elevated teacher ratings found across 3 independent samples highlights the importance of annual reevaluations to avoid treating children for problems that may no longer be present.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In type 2 diabetes patients, leukocyte telomere length is significantly reduced, whereas the telomerase activity seems less influenced.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "T3 levels were relatively high or normal, both before and during GH treatment, indicating that PWS children have increased T4 to T3 conversion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of T2D was high in this study and seems to be increasing compared to prior diabetes reports.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with severe pain immediately after vertebroplasty have similar long-term outcomes compared with patients without severe pain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IM provided a practical framework to guide the systematic development of a pediatric weight management intervention for parents of children with obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We identified two LPA variants that were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, due to our preliminary results, we do not found any inverse correlation between IR and male  reproductive functions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unboosted fosamprenavir should not be used concomitantly with posaconazole.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When choosing the best learning method for patients undergoing rehabilitation for stroke, the nature of the task should be considered.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggest that the protective effect of obesity in locally advanced NSCLC is not solely due to short-term treatment effects, decreased smoking exposure, or poor prognostic factors from underweight patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HeRO catheters offer a reliable, and possibly the last, alternative  in hemodialysis access-challenged patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prefix appears to provide a safe alternative to autogenous ICBG.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Monitoring of liver function and drug levels should be considered for some patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RGPC did not appear to directly affect general risk-taking behaviors  or STIs, since it focuses on diabetes and reproductive health issues.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, the burden of underweight was higher among prisoners in Tigray region who had respiratory tract infections.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, accurate preoperative diagnosis based only on imaging studies is difficult, and radical nephrectomy was performed for most of the patients in our series.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support the use of a supervised core-strengthening programme over a home-based programme to maximise improvements in core stability, especially in its dynamic aspects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Careful patient selection is very important.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Normal parturient plasma shows a large intrinsic pathway reserve for TG compared to adult and cord plasma, while TG in cord plasma is sustained by extrinsic pathway, and low levels of TFPI and AT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with BPH account for 27.1% of all patients seeking urological care at the polyclinic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As family support system is critical in maintaining the intervention effect, fostering positive parent-adolescent interaction and addressing adolescents' psychological needs should be included in preventive programs for Internet addiction in the future.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may help to identify high-risk subgroups at higher likelihood of AAA enlargement, such as nondiabetics, for surveillance protocols in patients  with small AAA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future interventions should include targeted and gender-tailored messages as a strategy to improve men's dietary intake within weight loss interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The perioperative ERAS program for total laparoscopic uncut Roux-en-Y gastrojejunostomy after distal gastrectomy is safe and effective and should be popularized.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Remnant cholesterol is strongly associated with premature myocardial infarction, can be easily calculated, and might serve as a new potent risk marker in this young patient population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The anaemia rates that we identify in this study classify anaemia as a severe public health problem according to the WHO.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings demonstrate the potential importance of MAOA and 5-HTTLPR polymorphisms in the treatment of IPV and drinking in men in batterer intervention programs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future interventions should explore the use of these intervention materials in conjunction with multilevel strategies, and particular attention should be paid to possible gender differences.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although clustered ring enhancement had one of the studys highest PPVs, this number falls below previously published rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results do not support the use of DL training as a method for reducing AH.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, body mass index greater than 25  and smoking history are cause for caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high prevalence of hyperlipidemia in patients infected with HCV is  observed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alogliptin can be administered without regard to meals and with metformin or cimetidine without the need for dose adjustment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cell phone technology allows snoring to be evaluated in patients located in areas remote from a hospital.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at clinicaltrials.gov as NCT02669602.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "n-3 PUFA supplementation ameliorates symptoms in elderly depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study, using a large dataset from an Italian population, has confirmed that smoking is related to age at menopause.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "3D MRI reconstruction after NAC could accurately detects the residual tumors after neoadjuvant chemotherapy, and contribute to select patients who received breast conserving therapy after NAC with tumor downstaging.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The exact importance of site of services and adherence support remains a significant area for future investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This meta-analysis indicates a significant effect of statin therapy  on plaque and external elastic membrane volumes and fibrous and dense calcium volumes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daily glucose fluctuation may have an effect on coronary plaque vulnerability in patients with CAD pre-treated with lipid-lowering therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lifestyle intervention Obeldicks light was effective in reducing degree of overweight, fat mass, waist circumference, and blood pressure  both at end of intervention and in a 12 months follow-up period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants felt that it is best placed as one method of accessing physiotherapy services, in addition to, rather than as a replacement for, more traditional face-to-face physiotherapy assessment and treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine involvement of GMS improved glycemic control in patients undergoing LER.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients admitted with ACS, statin use but not LDL-C level, was associated with a lower probability of presenting with STEMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future estimates of the burden of adiposity on health should include measures of central and general adiposity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings have implications for the understanding of impulsive behaviour under the influence of alcohol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the best of our knowledge, this is the first case of male beast cancer treated with exemestane and everolimus combination.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, surgeons should carefully interpret the histopathology reports  based on unusual or exceptional findings corresponding to the cholecystectomy specimens.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although overall survival remains high for all 3 treatment strategies, AT seems to be associated with a small absolute survival advantage over AS up to 10 years out from diagnosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study highlights the importance of monitoring for and addressing motor delays in children with a history of institutionalization, particularly those children with low IQ.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nonsurgical treatment of mandibular condylar fractures leads to acceptable remodeling of the condylar process, good clinical long-term outcome, and minimal subjective symptoms in most children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results highlight the potential of psychoeducation to facilitate helpful social support and reduce complicated grief.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SYSTEMATIC REVIEW REGISTRATION: PROSPERO: International prospective register of systematic reviews, 42016033948.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low dose of CC therapy was able to significantly increase serum T  levels in all participants with mild modifications of clinical and metabolic parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CHI is associated with high recurrence rate and the combined regimen seems to be necessary, in particular, in the presence of previous intrauterine death.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a need to develop a standardized laparoscopic technique for measuring small bowel length which is simple, reproducible, and easy to learn.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of overweight including obesity was stable among Swedish children between 2003 and 2011.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SPONSORSHIP: National Heart, Lung and Blood Institute, National Institutes of Health, USA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that leprosy-related lesions are not present in patients undergoing treatment for leprosy, probably due to response to multidrug therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings possibly have important implications for development of anxiety interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Through EBMI, both groups are equally effective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine antibiotic therapy is not necessary for managing MAS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither surgical care of the pelvis or retained fixation precludes successful vaginal delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among young premenopausal Chinese breast cancer patients who had received adjuvant chemotherapy, the current study has revealed that although there was only a median weight gain of 1.8\\xa0kg, there was a nearly 60% increase in abnormal BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnancies following RPOC after delivery entail a higher rate of abnormal placentation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EIC services should be made available to parents who are interested in the service.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A consistent proportion of endobronchial benign lesions are reported.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among middle-aged and elderly women in rural China, the nutrition status of anaemic cases is far below that of controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Acknowledging that sudden, large changes in fetal activity may be underreported in FM charts, our study showed that the temporal FM counting patterns in the two weeks preceding DFM-related consultation contributed little to identify clinically important changes in perceived FM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this risk is independent of body mass index.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to avoid the unnecessary hospitalization of patients with CAP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medical students should be considered as instructors for these courses given their favourable learning outcomes and greater availability.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This pilot trial confirmed the feasibility and need for a large, multicentre RCT to test these PVC insertion models.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Novel solutions to the problem of in-hospital falls are urgently needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The adoption of a comprehensive preoperative multidisciplinary approach led to significant improvements in the postoperative outcomes and also in the compliance to the postoperative follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we recommend the use of this type of exchange catheter for the extubation of patients undergoing maxillofacial surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, men who were formerly on long-term androgen suppression regimens should be especially prescribed exercise medicine interventions to alleviate residual treatment-related adverse effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no difference in the clinical or radiologic outcome between the all-inside arthroscopic MBO and open MBO for the treatment of lateral ankle instability at up to 1 year after surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data do not support the suggestion that the target TSH range for the treatment of primary hypothyroidism should differ from the general laboratory range.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its routine integration into their clinical management is proposed.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Researchers and clinicians should consider the possible limitations of each assessment when considering the most suitable tool for their purposes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of the DM2 patients that attended the nephrology units, less than 20% achieved a tight BP control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with long or highly irregular menstrual cycles have a significantly increased risk for developing type 2 DM that is not completely explained by obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The appearance frequency of eyelid pigmentation was similar among the five types of PG analogs studied, and eyelash bristles appeared less frequently with isopropyl unoprostone use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a very high incidence of constipation in ST patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Healthcare professional and family  support are key elements to empowering women with GDM and require further consideration in future interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Flexible ureteroscopy has proven to be the most successful treatment option, and can avoid the need for more invasive procedures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient navigation positively impacts time to resolution of abnormal screening tests for breast, colorectal, and prostate cancers in a medically underserved population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For geriatrics, oncology, gastroenterology, and internal medicine, this ratio was even greater (1 out of 3\u221a\u00a2\u201a\u00c7\u00a8\u201a\u00c4\u00fa4).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intensified therapy was effective, but target attainment was still low at 40.3% or 13.9% with regard to the new 2011 guidelines issued by the European Atherosclerosis Society (EAS) and the ESC on dyslipidemias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high prevalence of malnutrition and anaemia among the three age  groups, including moderate status of iodine deficiency among women and children,  are significant public health concerns.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In elderly hemodialysis patients, the impact of the BMI percent change on survival was stronger than that of the baseline BMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improving African womens knowledge and understanding will improve behaviors related to breast cancer and facilitate early presentation and detection and enhance proper management and treatment of breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ISRCTN22201583.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are several alternative models of minor surgery provision worthy of consideration, including ones based in primary care that require all excised tissue to be sent for histological examination, or that require further training of GPs to undertake the necessary work.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this multicenter, prospective study of bariatric surgery in adolescents, we found significant improvements in weight, cardiometabolic health, and weight-related quality of life at 3 years after the procedure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower bodylift is the only procedure, which can restore circumferential body contour.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This randomized trial should make a substantial contribution to the management of individuals with MFS and expand our understanding of the mechanisms responsible for the aortic manifestations of this disorder.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only a small minority of patients will not receive valve replacement therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study can be used to optimize the training of GPs using the EAP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cable-driven robotic resistance training may be used as an adjunct to BWSTT for improving overground walking function in humans with incomplete SCI, particularly for those patients with relatively high function.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pediatric practice is an important contact point and context for improving maternal folate use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intervention efforts need to focus on ameliorating the additional risk burden carried by orphaned children.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support treatment-to-target strategies and timely adaptation of therapy in patients with early RA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laparoscopic appendectomy reduces the need for analgesics and visual analog scale scores; therefore,it should be considered as the gold standard for surgical treatment of acute appendicitis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence of unsuspected GIST in LSG specimens in our series was  low and similar to what has been reported.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the convenience of a subcutaneous injection and no requirement for renal monitoring, denosumab represents a potential treatment option for patients with bone metastases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intervention effort is needed to reduce negative attitudes towards PWUD among MMT service providers to achieve greater consistency with best-practice recommendations.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for family interventions in the early phase of psychosis and the prevention of CC and EOI are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicaltrials.gov ID: NCT02002091.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NMDA receptor glycine site agonists may be potential pharmacotherapies for the prevention of relapse of appetitive motivation disorders with a learned component.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health care professionals are in an important role when considering support for grieving mothers; the given support may relieve the mothers' grief reactions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More demanding flap techniques and plasties should be reserved for complicated PS, which requires a wider excision.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to target never testers and integrate syphilis testing within HIV testing services are urgently needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A sizeable minority of BRCA1/2 mutation noncarriers choose to undergo CPM after learning their mutation status through pre-surgical genetic testing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results do not support the addition of 10 microg ITS to 0.4 mg ITM for colorectal surgery, as low dose sufentanil does not improve intraoperative and postoperative analgesia in this setting.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies that further define the etiology of breast cancer subtypes will add to the biologic understanding of this disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION NUMBER: NCT01969604; Results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Curcumin may be a safe and promising agent for treatment of UC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rather there appears to be a true association.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If specific volitional skills are identified as predictors of adherence to physical activity and success in clinical weight loss maintenance, these can be trained in future intensive lifestyle interventions in order to optimize the success rate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aerobic exercise training can be recommended for patients following atrial redirection surgery to improve exercise capacity and to lessen or prevent heart failure symptoms.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "UVR and vitamin D seem to affect MS risk in adults independently of HLA-DRB1*15 status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nitrous oxide inhalation was preferable to injectable ketamine for pediatric patients because it is safe, allows for a faster recovery, maintains sufficient sedation time, and does not induce unnecessarily deep sedation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of BoNTA may be expanded to prevent hypertrophic scar after trauma, burns, or operations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relatively reduced SPRs seen in this population support the need for routine screening and re-dosing in this population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov NCT01779479.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, complications and therapeutic interventions should aim at reducing such fluctuations.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Septal surgery with early removal of nasal packing is a clean-contaminated procedure and does not require routine antibiotic prophylaxis because of the low infection risk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings highlight the need for more prospective research into multicomponent physical activity interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For patients with moderate or severe AG, the combined CBT+SSRI treatment is recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, in view of the high false-positive rate of suspicious nodes detected  in luminal A tumors by MRI, proceeding straight to sentinel lymph node biopsy for all cases, except for those with highly suspicious findings, is suggested.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This tool may help evaluate the risk for a CV event in patients with COPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Being a simple, inexpensive, and reproducible marker of CVD risk, the TG/HDL-C ratio may emerge as a novel and reliable indicator among the many well-established markers of CVD risk in CKD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results could have implications in the analysis of IAS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both exercise programs showed functional benefits, but HICT might be the preferable option for strengthening in highly functional children with CP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov: NCT01562392.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, operative strategies should be considered to overcome the technical challenges during LSG in patients who underwent a prior abdominoplasty.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Coaches, the Unions/the South African Rugby Union and social media were the largest contributors to knowledge in coaches and players.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, local administration of lornoxicam during epidural anesthesia may present a useful option for the relief of post-epidural low back pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This level of exercise may increase HRQOL among overweight men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of the 4 methods studied, the optimal method to decrease the incidence and intensity of pain resulting from propofol injection is to inject lidocaine while applying venous occlusion for 60 seconds prior to administering propofol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Middle-age adult Asians with the ADRB3 rs4994 minor alleles are at increased risk of T2DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide additional evidence of differential effects of three sparing-prolactin antipsychotics on prolactin release and may help clinicians to decide among therapeutic options.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings can have important implications to oral vitamin D supplementation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for clinical decision making around treatment selection are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some of the opportunities may be related to differences  in hospital coding practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is mandatory to provide adequate information to the staff and parents in order to treat pediatric acute asthma successfully.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, higher order interaction analyses suggest a potential relevance of MTNR1B with the key transcriptional factor NPAS2 with ARNTL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger, longer term studies are needed to establish the impact of videogaming interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is concluded that music therapy-as an independent nursing initiative-can be used to help in fulfilling the physical, emotional, and psychological requirements of patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial clearly shows LA to be as effective as GA in the first line management of nasal fractures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Visit-to-visit variability in FPG and HbA1c levels are strong predictors of COPD in patients with type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Switzerland, the influence of socioeconomic factors on nutrient intake differs by sex; income and education, but not occupation, drive differences among men; among women, all three indicators seem to play a role.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this cohort of healthy young children, we found little evidence to support the need for fasting prior to measurement of lipids.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We could not find any relationship between postadolescent acne and nutritional anemia in our study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Safety and Efficacy Study of the Medtronic CoreValve(\\xc2\\xae) System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement; NCT01240902).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both conbercept and ranibizumab are effective in the treatment of DME, achieving the similar clinical efficacy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early detection and referral by both the patient and general practitioner are crucial for optimal foot ulcer healing.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite both groups achieving target daily weight gain after attaining full feeds, growth failure continued to be a problem after stage 1 procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, female gender has a significant negative impact on CSS in patients younger of age and with positive LVI status possibly suggesting different clinical phenotypes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "He achieved higher progression free survival with endocrine therapy creating the rationale for last line treatment with everolimus and exemestane combination.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ophthalmic Surg Lasers Imaging Retina.2017;48:399-405.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the sample size was small, the study was inconclusive and the results should be considered preliminary data of a study that needs to enroll 1626 patients to show a 0.5\\xe2\\x80\\x89mIU/L difference in TSH between the groups, with 90% power.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results show the existence of a low prevalence of peripheral artery disease in a population aged 45-74 years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its use in the ED in a select population of patients may be of significant value in identifying bacteremia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight cycling and somatic co-morbidities, but not age of onset of obesity, are the main factors negatively influencing psychological health in treatment-seeking, morbidly obese subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Melker\\xe2\\x84\\xa2 kit, with its many parts, and need for greater manipulation, is not as easily utilized or preferred in a confined space scenario.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no significant difference in macular structure-function relationship between early and advanced glaucoma groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One reason for this may in part be explained by was the low level of public worry about the possibility of catching swine flu.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications of the findings for policymakers and researchers are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fracture risk was site specific, changing from a pattern associated with obesity to a pattern typical of osteoporosis after surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that, when sunlight exposure is limited, doses of vitamin D2 higher than those currently studied may be needed.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with metastatic hormone-sensitive prostate cancer, the confidence interval for survival exceeded the upper boundary for noninferiority, suggesting that we cannot rule out a 20% greater risk of death with intermittent therapy than with continuous therapy, but too few events occurred to rule out significant inferiority of intermittent therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continued surveillance is needed to monitor the changing epidemiology of CA-MRSA and to inform clinical decisions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Australia and New Zealand Clinical Trial Registry (ACTRN12612001168842) registered November 2, 2012.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-mass enhancement in the setting of a known index cancer, older age, a landmark, and larger lesion size is more likely to be malignant.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with  hereditary cancer risk seems to be diagnosed with worse prognosis factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To achieve optimal treatment gains in patients with PGD, therapists should encourage some form of exposure therapy to memories of the death.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical, but not medical treatment, consistently led to clinically important improvements in HRQL  over two years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to its poor retention rate, periodic recalls are necessary, even after 6 months, to eventually replace the lost sealant.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the definition of contamination as \"PSA ever tested\" gives an indication of the proportion of contamination, it will be important to differentiate the screening use of PSA from its diagnostic use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because CO2 is not constant in patients with respiratory failure, but instead fluctuates, we would recommend the continuous transcutaneous measurement of PCO2 as our method of choice in the diagnosis of nocturnal hypercapnia.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Public policy makers may recommend retailers and manufacturers implement consistent front-of-pack nutrition labelling that contains both health marks and traffic light colouring as directive cues.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further multicentre, randomised-controlled studies are surely needed in order to elucidate these findings and to better ascertain the possible contribution of different therapeutic regimens to reduce this risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This observational study emphasises the high prevalence of overweight in the outpatient haemodialysis population, as long as overweight is related with fat and extracellular water.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metabolic disorders in this population may be due to HIV infection or lifestyle (smoking, sedentary lifestyle and inadequate diet).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Feedback training results in improved perception of respiratory sensations in children with asthma, a finding with implications for strategies of asthma self-management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support behavioral interventions targeting lifestyle physical activity as an alternative approach for managing symptoms in MS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite optimal multimodality therapy, 23% of the patients in this series with primary extremity sarcoma developed distant metastasis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated immunoglobulin E and immunoglobulin A levels were independently and positively associated with prediabetes prevalence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to control group, the isolated species from T2DM group had higher proteinase activity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baseline VAT was inversely and independently associated with the conversion to normal blood pressure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With a change in the galenic formulation FK 506 might be a powerful therapeutic option for preventing immunological graft rejection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative malnutrition was an important predictor of poor clinical outcomes in patients undergoing gastrointestinal operations in Hong Kong.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The long term effect of low GDP solution requires further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this cohort of obese youth, we found a high prevalence of breast-feeding, metabolic dysfunction, and wide variation in the LARs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study found that 27OHC does not independently increase the risk of CHD, does not modify the increased risk of CHD resulting from MHT, and does not mediate the interaction of LDLC with MHT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CGM users utilize CGM data to alter multiple aspects of their diabetes care, including insulin dose timing, dose adjustments, and in hypoglycemia prevention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It has therefore contributed to an improved  understanding of epidemiology and disease burden and may in future contribute to  improved management and outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of testosterone deficiency with frequency and severity of lower urinary tract symptoms, partially related with benign prostatic hyperplasia and clinically defined detrusor cistopathy, has been proven.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Provider cost performance is not associated consistently with clinical performance, although severity differences not captured by the casemix adjustment may account for these observations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABVS showed slight agreement with MRI in BRCA1/2 mutation carriers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A Web-based instrument should yield scores equivalent to those obtained by standard methods, providing a useful tool that may facilitate ophthalmic innovation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall results of this study, highlights the clinical value of CUSE in differentiation of breast masses based on their stiffness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Robotic procedure was feasible and could be implemented for treating  the first setting of mixed indications for gynecologic surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We present BMI outcomes  to allow an objective basis for patient counseling, risk stratification, maintaining access to orthopaedic surgical care, and maintaining hospital operating margins.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longer follow up will be necessary to evaluate long-term efficacy  and toxicity of 3D-CRT APBI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study showed associations between miRNA polymorphisms (miR-27a rs895819 and miR-449b rs10061133) and RPL development, and between the miRNA polymorphism (miR-27a rs895819) and plasma folate levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The improvement in glucose and insulin measures did not exceed the day-to-day variability of measurement for approximately 80% of the participants independent of exercise amount or intensity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High levels of ALT reflect acute, severe, but potentially reversible, ischemic liver cell necrosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the primary analysis showed no overall benefit, the subgroup analysis suggests that PN may improve satisfaction with care for certain disadvantaged individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From this study, it may be concluded that apoA-I and apoB serum concentration levels are independent risk factors for coronary atherosclerosis in the Iranian population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to determine both albuminuria and GFR estimation to diagnose KD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: KCSG BR13-11; ClinicalTrials.gov, NCT02263495.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there was a higher risk of complication with this tech\\xc2\\xadnique, which must be borne in mind when considering the clinical implications of our dataset.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The pilates method can be used by patients with LBP to improve pain, function and aspects related to quality of life (functional capacity, pain and vitality).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite growing availability of direct assays and increasing evidence of non-HDL-C utility, the Friedewald equation may offer better clinical utility for CVD prevention, especially in the screening of apparently healthy individuals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the results suggest that the use of PEC may positively regulate the intestinal microflora and thereby effectively lower the TC levels and thus act as a hypocholesterolemic agent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We firstly demonstrated in a European radical retropubic prostatectomy cohort study that MetS is associated with an increased risk of high-grade and advanced prostate cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The feasibility and tolerability of this treatment, coupled with its potential rehabilitative characteristics, make it an attractive new therapeutic option for men with erectile dysfunction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combination calcium and vitamin D treatment may be effective in preventing a second hip fracture in these patients, but its role in patients with hypovitaminosis D without secondary hyperparathyroidism and 'vitamin D-replete' subjects needs further evaluation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Orally administered nutritional supplements can help to prevent the onset of sarcopenic obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity slope appears to drive region-level heterogeneity and correlate strongly with explanatory factors, and may represent  a pertinent metric for public health monitoring.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The coracoid approach is convenient to perform with extensive block, and is thus an appropriate alternative to the vertical approach in infraclavicular block.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women in TOPS were more likely to achieve CSWL if older, \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022113\\u2009kg, and in larger, newer chapters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should incorporate information about genetic susceptibility, endogenous estrogen levels, and measurements of PFASs prior to diagnosis and treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive results in both treatment groups should encourage further research on osteopathic manipulative treatment and osteopathy in the cranial field and support the importance of an interdisciplinary collaboration in patients with temporomandibular disorders.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A better alignment does not necessarily yield more reliable perfusion values: color maps resulting from either alignment procedure must be critically assessed by radiologists.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This state is closely related to degree of blood glucose level control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary intervention was able to maintain body weight and food intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical relevance of this study is that the difference in blood loss between the PCR and PS techniques does not need to be considered by surgeons when performing TKA.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several factors are significantly associated with the self-acceptance of women with breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its usefulness for this application is questionable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings also indicate that new methods of intervention development and implementation should be explored.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also showed increased inflammation in both T1D and IA children when compared to controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, decisions concerning care for patients with acute LGIB should be based on individual experience and local expertise.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results have implications for how to improve primary care services related to decreasing children's media exposure and violence prevention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION NUMBER: Pre-results; NCT01483716.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support the need for further research into the use of targeted rehabilitation interventions among patients with elevated levels of catastrophizing and fear avoidance beliefs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We are uncertain as to the reason for this and do not know whether empowering the public and targeting GPs would have resulted in a successful intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One single dose of acetaminophen neither evokes a bronchoconstriction response nor an increase in airway inflammation in children with asthma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association between lower cholesterol levels and higher frequency of prior ischemic stroke in patients with cholesterol <5.5\\xa0mmol/L cannot be solely an effect of aggressive statin treatment in patients with prior ischemic stroke, as the association pertained also to patients who did not use statin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LAGB was associated with poor short and long-term weight loss outcomes and a high failure rate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study shows that for selected triple vessel disease patients, PTCA and CABG results are comparable after 5 years, though repeat revascularization (mainly due to restenosis) was necessary in the PTCA group to maintain these favorable results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results imply that school based nutrition education should be a part of comprehensive school health programs to reach students and potentially their families.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The DFS of patients staged pT3-4 pN1-3 cM0 was also improved.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chemoradiotherapy significantly impairs internal anal sphincter function and intrinsic nerves seem more susceptible than smooth muscle.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Screening MetS through introduction of HbA1c in addition to FPG could contribute to identification of more people with MetS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multiple and immediate access to the web-based education program at home may prove useful as a source of reference for women with GDM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TB incident rate among patients with type 2 diabetes was substantially higher among men than among women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mothers from food insecure households had a high risk of dietary inadequacy and obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the improvement of the pCR rate translated to survival outcomes in TN breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help guide the management of LBP in elite football players.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The minimally invasive approach provided us with the opportunity to repair the fistula, and it  was associated with a prompt recovery with very little morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Side effects, such as cataracts and elevation of IOP, may require medical or surgical  treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum RBP4 level is associated with the risk of GDM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall impact of implementing such a process is likely site-specific, and the decision to do so should involve consideration of the local context.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our study, helmet CPAP was a secure and well tolerated method in subjects who underwent pulmonary lobectomy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results raise doubt about the common clinical perception that exposure therapy is not effective or appropriate for individuals who have PTSD and dissociation, and provide empirical support for the use of exposure treatment for individuals with the dissociative subtype of PTSD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high proportion of breast cancer in young Pakistani females is alarming.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To optimize investment in telephone-based home interventions such as the HINTS, it is important to identify groups of patients who are most likely to benefit from more intensive home BP management.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eyes with VMT or VMA treated as needed required on average 2 more injections over 2 years.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sample size for a study to increase PA by 2.7 MET hours/week on pregnant women at high risk of GDM should be about 550 per group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, our results do not support adjunctive use of citalopram or reboxetine with risperidone or olanzapine for the treatment of negative symptoms in schizophrenia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MSCT allows a detailed assessment of the anatomy of congenital aortic anomaly, which can be used as an important supplementary method in diagnosing CHD and offer important information for operation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As there are no other tools for shock management outside of referral facilities, and no safety issues found, consideration of NASGs as a temporizing measure during delays may be warranted.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individually, EBUS-TBNA has the highest diagnostic yield in sarcoidosis, but it should be combined with TBLB for the optimal yield.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to understand and build upon the lessons learned from these types of trials so that we can design, implement, and disseminate successful evidence-based programs more widely and effectively.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no difference in age on presentation or treatment offered across all racial groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This randomized clinical trial demonstrated better postoperative outcomes at 6\\xa0months when subjects received preoperative IVB 5-10\\xa0days before PPV compared to 1-3\\xa0days for the treatment of PDR-related complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, inhaled budesonide is an alternative to systemic corticosteroids in AECOPD treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possible ADMA-lowering effects of vitamin E deserve further attention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Community-based studies are required to confirm this.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mindfulness practices can be taught in the workplace and may be a useful component of a multidimensional strategy to reduce burnout in this population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relatively small absolute reductions in non-HDL-C cutpoints result in substantial reclassification of patients to higher treatment categories with potential implications for risk assessment and treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effects of multivitamins on speeded attention such as the stroop task in young adults warrant further investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ExMI therapy might be a promising novel noninvasive option for primary dysmenorrhea.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continued research defining the role of MT intervention in improving the patient experience by reducing anxiety is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates that hypercholesterolemia is associated with NAION in younger patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetes is associated with less frequent use of HRT; conversely, osteoporosis/osteopenia is associated with more frequent HRT use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fuzzy-logic analysis was proven to be more powerful than the measurement of single markers alone or combinations using multiple logistic regression analysis of all markers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with a history of PMS and women with a high anxiety-related personality might respond with adverse mood effects to a combination of estrogen and sequential progestin and therefore a thorough evaluation should be made, at the consultation for hormone therapy, of mood benefits or disadvantages before initiation of treatment and there should be a close follow-up after.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that the five ear acupuncture points, generally used in Korean clinics, and the Hunger point alone treatment are both effective for treating overweight people.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The efficacy and safety of drotaverine as analgesic in renal colic is noninferior to diclofenac and may be used as an alternative or add-on therapy to currently available options.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Providing kilocalories per kilogram or grams of protein per kilogram early post-ALI diagnosis at recommended levels was associated with significantly  higher hazards for mortality, whereas higher late energy intakes reduced mortality hazards.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We concluded that in treatment of hydatid cyst, albendazole should be continued at least for 3 months preoperatively and if still viable scoleces are identified, medical treatment should follow the surgical intervention at least for 1 month to decrease the possibility of residual cysts and recurrence.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support that family-based cohorts can be an efficient way to examine gene-environment interactions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relatively small number of patients (P=.002) is a potential limitation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was evidence of neurological changes in the cortical location and in the bandwidth targeted by the intervention, and changes in EEG activity were predictive of symptom reduction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low-volume HIT provides an alternative to the current, more time-intensive prescription for cardiac rehabilitation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research should explore the interactions between multitasking and safety, fall risk, and function in this vulnerable population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high-quality walking footwear provided to both groups may explain this finding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Northern excesses in blood pressure and BMI may be associated with differential clinical management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An ice cream test may serve as an alternative to a 75-g OGTT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the other hand, the decrease in leptin and leptin:adiponectin ratio assessments could reflect an amelioration of the cardiovascular risk profile linked to hyperleptinaemia in ageing men with T2D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by River Vision Development and others; ClinicalTrials.gov number, NCT01868997 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contemporary practice, survival for patients with 3-vessel coronary disease is better after CABG than PCI, an observation that patients and physicians should carefully consider when deciding on a revascularization strategy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower miR-10a-5p expression in Ta progressing tumors indicates that this microRNA could be important for later malignant potential among this group of patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No other clinical characteristics were associated with HCV RNA levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower copper doses and restrictions of manganese and chromium supplementation may be needed to avoid their accumulation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of older Medicare beneficiaries with breast cancer treated with AIs do not undergo appropriate bone mineral density evaluation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutritional screening in all pediatric SCI patients should be performed periodically.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No differences were found between the type of procedure the patient underwent and the presence or absence of prostatic infection.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased non-HDL-C levels are a risk factor for renal function decline in HIV-infected patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "FCM could attenuate the allergic inflammation of bronchi to improve its hypersensitive state in children with asthma, and shows a cooperative action with Flixotide.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PLQ is an effective traditional medicine for AS with mild adverse reaction, it can be used as an adjuvant therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was also a trend for diagnosis of sporadic PNET associated with heavy smoking.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnant patients are prepared to use a health information website and web-based health records.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Virological response during HCV therapy was associated with an increase of sFas and sFasL, and maintenance of increased concentrations of sTNF-RI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ZOL did not improve DFS when combined with CT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the advantages of the PAE procedure must be weighed against the potential for technical and clinical failures in a minority of patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Li maneuver is a rapid, simple and efficacious repositioning method for geotropic HC-BPPV and can be widely applied in clinical practice as an alternative method.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To ensure safety, prior TEE may be necessary for the patients with planned catheter ablation for AF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Differential DNA methylation at the PPAR\\xce\\xb3 promoter can be detected within the pool of cell-free DNA of human plasma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After mastectomy, RT is recommended in all node-positive stage III cases.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Religious-themed PA interventions can be effective; however, specific adjustments may be needed to optimize the intervention's effectiveness for a broader population of students.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Potential confounders including age, educational status, health-related behaviors, and comorbidities explained parts of the inverse relationship.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to promote growth in infants should include prevention or treatment of maternal depressive disorders and strategies to ensure adequate food security.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There has been an 80% relative reduction in blinding trachomatous corneal opacities over the 10 year period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results may be inflated by selection bias, bias in diet reporting, or residual confounding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in the presence of platysma bands and/or local fat deposition, an anterior neck procedure-liposuction and/or anterior platysmaplasty-should be incorporated in order to optimize the results.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this experimental model, the antiseptic pomade was effective in reducing bacterial colonization on silk braided sutures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Advances in knowledge: MR lesion characteristics may not be helpful in determining whether small lesions on MR are benign or malignant.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two regimens increased the cholesterol efflux capacity of HDL comparably.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endoscopic surgery may be an appropriate substitute for stereotactic aspiration.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using routinely available clinical data, LIPS identifies patients at high risk for ALI early in the course of their illness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mini Nutritional Assessment was able to predict the development of PUs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CEC is independently associated with carotid plaque in patients with RA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adherence to a healthy diet may play a role in reducing the risk of extrahepatic BTC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Registered: 27 February 2017 (retrospectively registered).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depending on the circumstances of the procedure and the experience of the operator, either gauge may be appropriate for an LP in a child.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigation into the molecular mechanisms through which HDL-3 is associated with protection from CAAD is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that the VAI may be utilized as an additional indicator of long-term CVD risk for Caucasian/Mediterranean men without previous CVD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The complex role of adiponectin in the pathogenesis of IR and hepatic necroinflammation in chronic HCV infection merit further investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We demonstrated that effective posterior drainage is important to prevent posterior pericardial effusion, and use of a thin drain placed retrocardially appears to be sufficient for these results.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, it was in correlation with the age of patients and the existence of  chronic kidney disease, which are well-established predispositions for poor nutritional status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support the assumption of non-inferiority of ibuprofen compared to ciprofloxacin for treatment of symptomatic uncomplicated UTI, but need confirmation by further trials.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Undernutrition at the time of ART initiation was associated with increased risk of death, particularly during the first 3\\xa0months after ART initiation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tensile stress conditions need to be chosen with the desired outcomes considered.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Schools can promote healthy eating habits by making healthy choices easy during the school day.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caries prevention may be achieved by using Er:YAG laser treatment if the optimal range of laser parameters for LICP can be employed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other interventions may need to be combined with the workshops, to reach sufficiently high chlamydia screening rates to significantly reduce prevalence of chlamydial infection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future prevention endeavours in hockey and other sports should attempt to incorporate strategies and modalities to enhance knowledge retention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Total blood cholesterol tended to decrease with increasing injury severity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals with BED had increased utilization of psychiatric and nonpsychiatric medications compared with matched controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our interim analysis showed that elective repair of subclinical stenosis in AVFs with Qa > 500 mL/min cost-effectively reduces the risk of thrombosis and access loss in comparison with the approach of the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines, raising the question of whether the currently recommended criteria for assessing and treating stenosis should be reconsidered.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Substantial WL may predict for poor overall survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intensive SBP control after ICH was difficult to achieve within 1 hour in those with risk factors for resistant hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Luteal phase estradiol levels were suggestively associated with ER+/PR+  tumors but no other strong associations were observed with estrogens.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrates poor knowledge on breast cancer risk factors,  symptoms and curability among higher secondary school students in Western Nepal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LOS of stroke patients in Nigeria was shown to be prolonged especially when compared to similar settings in West Africa.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we found that weight loss >7 kg, use of stavudine and long duration of HIV infection were significant risk factors for clinical lipoatrophy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SPT are rare neoplasms with malignant potential.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions aimed at reducing weight and treating dyslipidaemia should be instituted early in order to reduce this risk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In ACS patients, without previous history of DM, MS is highly prevalent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Established measures of T2D risk remain the best predictor of T2D risk in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, a greater attention on such expectations may facilitate the patient's transition from hospital to home after stroke.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Earlier diagnosis and treatment of patients with FH are needed to reduce CHD risk in these patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings also illustrate the importance of using multidimensional tobacco dependence assessments.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01056406.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Definitively, patients preferred H-s.c. as reported in early stage by PrefHer study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nearly all measures contributing to three-dimensional gait parameter assessments were within predefined acceptable limits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most re-excisions are for involved margins rather than close margins.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If a patient cannot sense the application of a 4.5-g monofilament under either first metatarsal head, he or she probably has lost protective sensation and should be considered to be at risk for undetected injury.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Generally, sharing controls is likely to work well when strict frequency matching is not required and there is a large overlap of interview questions, other data to be collected, and eligibility criteria among the studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vesicostomy is a simple surgery that protects the upper urinary tract, decreases hydronephrosis, and improves kidney function.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study seems to indicate that THL ovarian drilling may reduce the risk of ovarian adhesion formation and could be used as a safe and effective option to reduce ovarian adhesion formation in patients undergoing ovarian drilling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low-income Americans require even greater efforts to improve their health than they currently receive, and such efforts should be a priority for public health policymakers.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work should explore new methods to improve tendon healing and reduce the high rate of re-tears observed in this trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment of newborns of extremely low gestational age with late surfactant in combination with inhaled nitric oxide decreased use of home respiratory support and may decrease persistent pulmonary morbidity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results warrant attention when promoting adherence to BT sleep interventions during chemotherapy treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high efficacy of the TTO/LO product and the head lice \"suffocation\" product offers an alternative to the pyrethrins-based product.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In ATARAO and ANRS, malnutrition was common across all indicators (BMI, hemoglobin, albumin) and persisted despite treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In young myopic OAG eyes, there is no significant nocturnal elevation in habitual-position IOP, while IOP increases at night-time in age-matched control eyes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Modafinil had no effect on cancer-related fatigue and should not be prescribed outside a clinical trial setting.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Irrespective of the strategy, increasing from 1 to 2 SMBG tests/day was associated with HbA1c reduction in both groups, without pharmacologic interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Influenza vaccination can be performed concurrently with cytotoxic chemotherapy or during the cytopenic period.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the significant association of B4a1a and E2b1 with T2D ceased when corrected for multiple testings, these haplogroups are seen only among Taiwan Aborigines, Southeast Asian and the Pacific Ocean islanders where T2D is predominant.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A simple approach of offering an OGTT to women  25 years or older and/or with a BMI of 25kg/m2 or more is as good as more complex risk prediction models.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Difference in strength of association between isolated diastolic high blood pressure and isolated systolic high blood pressure with body mass index was also found.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pharmacological aids and lifestyle modification are required to improve cardiovascular risk factors, subsequent mortality risk, and promote T2D remission.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was greater adverse influence of NAFLD per se on triglyceride,  and triglyceride/HDL-cholesterol in men compared with women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Speech-in-noise performance was related to a combination of auditory and nonauditory factors, confirming the important role of audiology in MTBI rehabilitation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pharmacists provided extensive interventions to patients with hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings of this study indicate that patients with diabetic foot infections present a challenge that is beyond the expertise of a single field of  medicine.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvements in balance may not be a prerequisite for improvements in walking distance when assistive devices are allowed during walking tests.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EVR is less invasive but equally effective in the mid-term, albeit at the cost of multiple secondary interventions, and is an appropriate primary treatment for benign SVC syndrome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the stepwise approach using DGT followed by WGC-PS as needed facilitated successful biliary cannulation and reduced the need for the needle-knife precut technique.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings have implications for revisions of DSM and ICD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The result shows metformin use is a protective agent against TB infection in diabetics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results suggest that a modest intervention linking older adults to HCBS may have important cost-saving implications for HMOs serving community-dwelling older adults with high healthcare service utilization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests that osteosarcopenic elements exist even in very young populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for theory, research, and practice are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The decline in effectiveness of intervention effects underscores the need for permanent cueing devices and follow-up treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HP status was not associated with changes in metabolic profiles and  co-morbidity status, or in the efficacy of LSG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children with acute neurological diseases are hypercatabolic and have high urinary nitrogen losses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Amniotic membrane grafting is a simple and straightforward surgical technique which should form part of the therapeutic arsenal for the treatment of ocular surface disease.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This approach allows to reduce examination time and costs as well as minimize contrast-agent exposure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A significant difference in effect was found between patients with weight loss failure and weight regain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The diagnosis of biceps tendinitis (OR, 3.5) or long  head of the biceps tearing (OR, 5.1) at or before the time of surgery was an especially significant risk factor for revision surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov: NCT0186953.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings show for the first time in a large-sample, long-term, prospective study in Europe that the VAI is independently associated with elevated 10-year CVD risk, particularly in men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nearly 50% of fit women with high-risk disease did not receive adjuvant chemotherapy suggesting under treatment in this group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C. albicans remains the predominant pathogen in diabetics, although other species are on the rise.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Central adiposity may have a stronger effect on stroke  risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies of cardiovascular function from preconception to postpartum will provide more reliable estimates of the influence of cardiovascular maladaptation during pregnancy complications and  their effect on longer term cardiovascular function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggests that a chronic high dAGE diet could lead to a vascular dysfunction and inflammatory activation, contributing to the development of vascular complications in subjects with type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This emphasizes the critical importance of routine surveillance of 25-OHD and BMD, as well as consideration of alternative methods of supplementation after weaning off PN.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "And its combination with T-SPOT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that injection-site reactions are more extensive after the fifth consecutive dose of an aP combination vaccine compared with the fifth dose in a mixed series of whole-cell and aP combination vaccines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Undiagnosed celiac disease appeared to be clinically silent and remained undetected, but long-term outcomes have not been determined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ZnC, taken alone or with colostrum, increased epithelial resistance and the TJ structure and may have value for athletes and in the prevention of heat stroke in military personnel.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More investigation is needed into the effect of obesity on clinical outcomes, as the current literature is mixed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the present study indicate that a 5-week neck strengthening program improves isometric neck strength in rugby union players, which may have implications for injury prevention, screening, and rehabilitation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hypothalamic MRS-response reached its maximum prior to subsequent increases of ACTH and cortisol, which support the functional relevance of hypothalamic Glx-depletion for activation of the HPA-axis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide initial support for the efficacy of a default option in facilitating healthier food choice behaviors within financial constraints.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, among men with dyslipidemia, elevated cholesterol and HDL levels were associated with increased and decreased risk of recurrence, respectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These changes in insulin PD should be weighed against the added convenience of mixing when considering such unlicensed use of these insulins in youth with type 1 diabetes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests intravitreal steroids (triamcinolone, dexamethasone implants) significantly reduce HEs in DME patients on short-term follow-up, whereas intravitreal bevacizumab does not.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this series, exclusion of plaques prevented plaque complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was up to 14-fold accurate than Kato-Katz which had extremely inadequate sensitivity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In women with nipple discharge and negative or inconclusive mammography findings, the risk of malignancy is low, at 5.7%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have important implications for identifying adolescents who may benefit from different or additional intervention, and for anticipating and informing families of adolescents' potential drinking course following treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of its low radiation dose, we believe that CBCT can be used in current practice as a replacement or supplement to radiographs to detect these fractures and optimize the cost-effectiveness ratio by limiting the number of needless immobilizations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This large-scale study indicates that leukocytapheresis, including intensive procedure, is a safe and effective therapeutic option for active ulcerative colitis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows heterogeneity in patterns of growth trajectories.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment of hyperlipidemia with medication though surprisingly common  could improve.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients who are super obese are at increased risk for serious complications compared with patients with morbid obesity, whose risks are elevated relative to patients whose BMI is less than 40 kg/m2.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a clear need for improving folates intake in the Spanish population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high S-dThdPase is associated with depth of tumor invasion and poor response to treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Withholding radical treatment in men with low to intermediate risk screen-detected PCa leads to a substantial delay or even avoidance of radical treatment and its potential side-effects in a majority of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A dose of 1 mg/kg of tramadol administered intravenously 30 minutes before the expected extubation, compared with 1 \\xce\\xbcg/kg of fentanyl, decreased cough incidence, improved emergence quality, and provided stable hemodynamics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clozapine is of benefit in reducing the clinical severity of ASPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-dose atorvastatin significantly improved the PD effects of double-dose clopidogrel in our stable CAD patients with HTPR undergoing PCI (Atorvastatin and Clopidogrel HIgh DOse in stable patients with residual high platelet activity [ACHIDO]; NCT01335048).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it may be used as an effective tool in childhood and adolescence obesity prevention programs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evaluation at 3 months indicated similar rates of problems in EuroQol (except for pain/discomfort) and World Health Organization Disability Assessment Schedule 2.0 scores were similar.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional modifications are needed to improve the efficiency and design of this novel robotic device further.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Remifentanil (0.5 microg/kg) at the induction of anaesthesia in elective Caesarean section under general anaesthesia can be used without subsequent neonatal depression.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replication should be made to compare self-help and telephone treatment based on cognitive behavior methods with nonspecific interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Apelin could be playing a role in MM pathogenesis; and apelin level could be used as a diagnostic and prognostic biomarker in MM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the results of this study showed that both labor pain and overall birth experience played a role in the development of posttraumatic stress symptoms after childbirth, overall birth experience appeared to be the central factor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR-IPR-15006069.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That males and females were generally similar in anger is worth noting in relation to other studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When clinically indicated, sonographic guidance can be used to accurately identify the LBHT within the intertubercular groove.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2018;124:36-45.\u221a\u00c7\u00ac\u00a9 2017 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings provide preliminary support for the utility of massage therapy as a nonpharmacologic treatment for individuals suffering from migraines.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Larger prospective series are necessary to evaluate if the modest benefits are worth the risks of secondary LAGB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attention to health risks in health care workers remains an important area of study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical relevance of the study is that the combination of ropivacaine, morphine, and ketorolac can be a good option for periarticular injection following TKA in terms of synergistic analgesic effect and efficiency of drug combination.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The estimated cost per QALY gained was below the threshold recommended by English decision-makers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the extent of tolerable thermal trauma by the pulp tissues is unknown, care and consideration should be given to the choice of LCU and the exposure time when curing RBCs, and especially during bonding.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher total cholesterol and LDL levels were associated with increased risk, whereas higher HDL levels tended to reduce the risk of AMD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LIMITATIONS: It was difficult to establish temporality in this cross-sectional study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, promoting social support for the IMSS diabetic patients could be a useful intervention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, these methods, as effective non-pharmacological strategies, can be introduced to the medical staff to improve the delivery outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of the 308-nm xenon chloride excimer laser is an additional effective therapeutic option for the treatment of psoriasis vulgaris.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African Americans with vitamin D deficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The underestimation rate of ultrasound-detected non-mass lesion was significantly lower with VAB than with CCNB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results, combined with existing clinical experience, provide evidence that dihydrocodeine is a viable alternative to methadone as a maintenance treatment for opiate dependence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Electrical cardioversion has a favourable safety profile and appears to be a more effective method than pharmacological cardioversion for the treatment of permanent AF after cardiac valve replacement, once the heart has returned close to its normal size.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "25(OH)D had significant inverse and direct relationship with FBG and WC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Minimally invasive, endoscopic saphenous vein harvest may be beneficial for both leg bypass patients and coronary artery bypass patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "even with recommended intake of vitamin A, we found a biochemical and functional inadequacy of vitamin A nutritional status,associated with overweight, obesity and body adiposity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, subjects with diabetes had significantly more components of the metabolic syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PON1 55 M allele is a risk factor for psoriasis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This evidence indicates that AVNFH was significantly associated with blood lipid abnormalities in elderly patients with low-energy femoral neck fractures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The LDL-C response in children and adults was related to underlying genetic mutations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TPE therapy (combined with immunosuppression) was an effective tool in most pediatric cases after renal transplantation with low incidence of minor adverse events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the addition of exenatide  BID to insulin glargine as an option for Latin American patients unable to achieve glycemic control on basal insulin alone.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with FPG-CV higher than 34.6% or HbA1c-CV higher than 8.4%  exhibited an increased risk of COPD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "VAI is an optimal method to measure visceral adiposity to assess long-term CV outcomes and all-cause mortality in prevalent hemodialysis patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To overcome these barriers and ensure opportunity to residents increased provider and sector support is required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the era of molecular selection of patients for adjuvant chemotherapy, this study offers valuable information for the optimal administration of anthracyclines and taxanes in patients with node-negative disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A rise in ketones following alcohol ingestion occurred despite subjects being in a strictly controlled environment with no interruption in insulin administration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cluster membership was related to differing health-related quality of life, with children from the all-rounders cluster consistently reporting greatest health-related quality of life at sites around the world.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, all women \u221a\u00a2\u00ac\u00a9\u00ac\u00e670 years deemed fit by CGA underwent primary surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results should assist physical therapists to recognize patients who may have lower expectations of recovery and plan pre-treatment education interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The associated increase in the delay in obtaining an angiogram may reflect the increased workload encountered by the neuroradiologists.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the superiority of the LCD disappeared  1 year after the intensive intervention, these data suggest that well-constructed nutrition therapy programs, both CRD and LCD, were equally effective in improving HbA1c for at least 1 year.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The numbers of microcephaly reported here are much higher than the 6.4 per 10\\xc2\\xa0000 live births reported by the Brazilian live birth information system.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research should focus on prevention of attrition in families with a lower educational background.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EuroSCORE II did not estimate mortality risk better in comparison to its previous versions, in the entire studied population or in the CABG patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More prospective cohort studies with longer follow-up durations  are warranted to confirm this association.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baseline PaCO2  predicted persistent ventilatory failure on treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ADM allografts may be the application of choice at implant sites in need of major grafts and in patients where a donor site should be avoided for medical or psychological reasons.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed patterns of residual risk may aid clinicians in multidisciplinary monitoring of male and female patients with Fabry disease receiving ERT, and in determining the need for administration of adjunctive therapies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reflecting the reality of clinical practice in resource limited settings, new diagnostics such as Xpert serve as important adjunctive tests but will not obviate the need for astute clinicians and comprehensive diagnostic algorithms.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consumers and food service workers should be educated about cooking hamburger meat thoroughly.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding was not seen when only using cross-sectional analyses, thus highlighting the importance of taking a life course approach.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Automated algorithms can be used to reliably assess choroidal thickness in eyes with DME.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Provision of take-home emergency naloxone prior to prison release may be a life-saving interim measure to prevent heroin overdose deaths among ex-prisoners and the wider population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a 12-week clinical trial in overweight adults, YY-312 resulted in significantly greater reduction in body fat vs. placebo, while being safe and well tolerated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multifaceted, appropriate and practical approaches are required in pregnancy interventions to improve pregnancy outcomes for less educated women.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although iloprost influences the inflammatory cascade in SSc, no statistical differences were seen in our study, indicating that treatment strategies with iloprost should be modified.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We determined it would be feasible to conduct a full-scale trial of a psychosocial intervention targeting adults with CHD, although with modifications to address practical barriers to participation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support treatment of LSIL in human papillomavirus test-and-treat approaches for cervical cancer prevention in resource-constrained settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They allow patients to eat orally, thereby improving patient satisfaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some subjects were diagnosed with CD within a decade of serum collection, indicating that although most cases of undiagnosed CD are clinically  silent, some result in symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Old age and cumulative chemotherapy cycles were the main influential factors for objectively confirmed cognitive decline, and fatigue was the most common predictor of self-reported cognitive decline.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Home pedometer assisted PA may be a useful and cheaper alternative to outpatient supervised exercise training programs in patients with COPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ICBT appears to be effective in reducing severe fatigue and related  symptoms and meets the current need for easy accessible and more efficient evidence-based treatment options for severely fatigued survivors of breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long sleep duration and afternoon napping were independently and jointly associated with higher risk of incident diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum sEGFR, a novel biomarker in preeclampsia, may be involved in the pathogenesis of preeclampsia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A combined procedure of percutaneous pulmonary core biopsy and stereotactic seed placement can be performed without additional risk of a major complication when compared to performing these separately.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, we analyzed a relatively small, homogenous sample of older adults with and without type 2 DM and factors such as  peripheral neuropathy and the use of multiple comparisons complicate interpretation of the data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The metabolic risk associated with obesity in childhood is conferred prior to reaching class IV obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PROMIS\\xc2\\xae provides a feasible means to collect data in this population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This risk determination identifies a potentially modifiable risk factor for early readmission.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is easily accessible and could be helpful to community optometrists managing patients with a melanocytic fundus lesion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be used for axillary staging, but nevertheless the technique should be applied with attention to the tumor size and grade to avoid false negative results.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "dMMR biliary tract cancers associated with LS are rare but long-term outcomes may be more favorable than contemporaneous cohorts of non-Lynch-associated cholangiocarcinomas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests that the ATM rs189037 polymorphism is associated with reduced risk of T2DM in older adult population in China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both aromatherapy massage and aromatherapy inhalation may have important implications for intervening depression in older adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: German Clinical Trials Register (DRKS), Freiburg University,  Germany, DRKS-ID: DRKS00000494.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This diurnal variation should be taken into account in the daily management of knee OA.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, most had playground equipment, courts, and outdoor play areas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further prospective studies are warranted to explore effective interventions to improve the poor outcomes of diabetic patients undergoing hepatectomy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, our findings may have potential implications for a medication intervention that could prevent potential deleterious side effects and improve health-related quality of life in this frail population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further strategies to improve growth during initial hospitalization are needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This should be kept in mind at their follow-ups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the latter, flexible and adaptive working conditions might alleviate burden and therefore reduce the DTI of the PWD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At present, CPAP treatment should be advocated for patients with stroke only if they have symptoms of SDB.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The structure of households is evolving under the pressure of social change and increased mortality due to HIV/AIDS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inverse associations of eicosapentaenoic acid and docohexaenoic acid with incident CVD were observed only in women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addition of prilocaine-lidocaine cream application to INB may not provide better analgesia.&nbsp;", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Presentation of clinical characteristics such as baseline acuity and infiltrate scar can provide important information to clinicians about prognosis, and may help guide management and treatment decisions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "50/125 (40%) patients imaged for pre-SC/post-SC had orbital abscess; 44/50 (88%) of these involved the medial orbit.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This prospective study assessed pyloric compliance for the first time, and showed that fasting pyloric compliance is decreased in gastroparetic patients and is associated with T1/2 , symptoms and quality of life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the study should be interpreted in light of the premature termination of the trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed to characterize the etiology of anemia in this population and  identify effective interventions for reducing prenatal anemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results therefore support the conduct of clinical trials to investigate efficacy, tolerability and pharmacokinetics during repeated dosing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this contemporary, cross-sectional, big data analysis of US adults who underwent advanced lipid testing, the extent of patient-level discordance suggests that TC/HDL-C may offer potential additional information to  LDL-C and non-HDL-C.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results suggest that the genetic polymorphisms of SREBF2 gene may be associated with MetS in patients treated with clozapine.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the SF-12v2 was found to have adequate psychometric validity in our sample of adults with hemophilia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A single i.v. bolus of carbetocin and umbilical vein injection of 50\\xe2\\x80\\x89IU oxytocin are similarly effective in reducing the need for manual removal of the placenta.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Administration of misoprostol 400 \\xce\\xbcg orally for cervical ripening before tandem application facilitates the procedure, increases patient tolerability and comfort, and may decrease complication rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients that received fast track care had a decreased length of stay.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of fibrin gel after LM is recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GNRI at admission may independently predict FIM gain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to pharmacologic therapies and dietary interventions, providing behavioral therapy targeting healthy Internet use may be promising to reduce the effects of obesity in adolescence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrated that oral omeprazole significantly excels intravenous cimetidine in reducing the need for blood transfusion and lowering rebleeding rates in patients with upper gastrointestinal bleeding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tobacco control laws outlawing their sale are not being enforced.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight-based norepinephrine dosing using actual body weight did not result in more tachycardia in the morbidly obese compared to normal weight patients, despite greater total exposure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medical-vocational rehabilitation could be a treatment option; its efficacy and benefit (in IBD) are still to be demonstrated.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of this study can be used by future clinical researchers designing protocols to test the full multi-staged approach for the treatment of pediatric overweight and obesity in primary care clinical settings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.govNCT00081328.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results inform the future scale-up of obesity prevention programs, providing an improved understanding of strategies to optimize implementation of evidence-based prevention programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epigenetic age acceleration and CpG island methylation have a weak, but statistically significant, association with breast cancer susceptibility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intravitreal injections of bevacizumab seem to reduce NVI and IOP in NVG and may be considered as an adjunct to more definitive surgical procedures for NVG.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Androgens were associated with modestly increased risk of breast cancer in this population, with stronger associations for invasive and ER+/PR+ disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions should focus on strategies to decrease the number and duration of night awakenings.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NAION may be the first manifestation of a lipid disorder, a previously unrecognized syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the idea that telmisartan exerts its PPARgamma enhancing activity clinically in obese type 2 diabetic patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For patients with de novo long coronary artery disease, R-ZES implantation showed noninferior angiographic outcomes as compared with SES implantation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical insulin 0.5 units QID is most effective for healing corneal  epithelial defect in diabetic patients after vitrectomy surgery compared with placebo and higher concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To explore the intensity of snoring and  to postoperatively monitor the efficacy of surgery used to treat snoring, telephonic sound analysis is both new and effective and reduces the need for patient attendance at a hospital.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The low molecular weight forms of AGEs predict mortality in patients receiving chronic haemodialysis, and may be important in the mechanisms leading to atherosclerosis and inflammation in such patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reasons for the high rate of congenital anomalies are uncertain, but may include poor metabolic control and extreme obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although this study investigates women with gynecological diseases,  the postmenopausal ovary is hormonally active, and the E2 produced by postmenopausal ovaries may therefore contribute to the maintenance of lipid metabolism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity is predictive of an increased risk for cardiovascular and respiratory complications following trauma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We determined that malnourished COPD patients have higher airway obstruction degree, perception of dyspnoea, CAT score and lower exercise capacity and FFM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should be considered by patients, clinicians and health-care policy-makers to determine whether or not a change in practice is worthwhile.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The two drugs showed no significant differences in urinary 8-iso-PGF2\u221a\u00e9\u00ac\u00b1 and FMD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Male sex predicted lateral meniscal tears and management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gadolinium chelates may be used as an alternative CT contrast agent in patients who cannot receive iodine.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also demonstrates a direct relationship between the severity of coronary atherosclerosis and the number of lesions in the involved vessels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DAS without the RAI perform comparably to the original DAS and may be chosen as alternatives.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found limited evidence linking sitting and incident diabetes over  13 years in this occupational cohort of civil servants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings also suggest that exercise specificity should be considered when prescribing resistance exercises to improve physical function in older adults.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daily consumption of 3\\xa0g of soluble fiber from 70\\xa0g\\xa0of oats leads to beneficial effects on the lipid parameters, specifically total cholesterol and low-density lipoprotein cholesterol in hypercholesterolemic Asian Indians.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Applied relaxation can be used to treat vasomotor symptoms in healthy postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results provide empirical support for the proposed hypothesis that AS may hinder multimodal treatment outcome for pediatric OCD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study provides a good opportunity to review changes in burn care over a long time period, at a single center, including children and adolescents, with stable surgical and rehabilitation staff.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial was registered at the London-based Current Controlled Trials register as ISRCTN35739639.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HRP is an alternative to polysomnography in patients with suspected SAHS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such individuals might be at risk of significant ketosis  in less-controlled circumstances where insulin administration might be more erratic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HES 130-0.4 solution is an alternative colloidal solution which can be used as the prime solution or as a mixture with the crystalloids in cardio-pulmonary bypass applications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Integrating geriatric assessment tools into HIV/AIDS clinical care may help target interventions to optimize clinical care and quality of life for older HIV-infected individuals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanism is not due to an altered immune response, at least as measured by a broad panel of circulating and cell surface markers, but may be due to worsening of pre-existing cardiovascular and kidney disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several glycerophospholipids were inversely related to advanced stage  disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with findings in untreated ADHD in adults, untreated ADHD was a significant risk factor for SUD in adolescence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were no statistically significant differences in measured variables found between the two study groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early support for mothers of very preterm born infants to develop a healthy mother-infant relationship is recommended especially for mothers who report negative first experiences.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the present study confirm that simple non-invasive intervention aimed to normalize BMI and to control risk factors through appropriate lifestyle can be highly effective in reducing the AF burden, by acting on comorbidities and proarrhythmic mechanisms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chronic kidney disease patients have increased cardiovascular event risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This observational study was registered at www.clinicaltrials.gov as NCT00005271.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was shown that three months use of NIV at home could reduce the PaCO2 and improve exercise tolerance (6MWD) in chronic hypercapnic COPD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is sensitive to clinical change and should be a valuable measure of outcome in cardiovascular research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The benefits were achieved by simply distributing the workload and organizing schedules, without new investments or additional personnel.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biphasic NCPAP may be used to assist in weaning from mechanical ventilation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pravastatin;s effects on the expression of these pivotal inflammatory mediators strongly support its well-timed use in CPB.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ezetimibe increased the efficiency of reverse cholesterol transport  from rapidly mixing plasma and tissue pools into the stool.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PPAR\u221a\u00e9\u00ac\u00a5 peroxisome proliferator-activated receptor \u221a\u00e9\u00ac\u00a5, STAT3 signal transducer and activator of transcription 3, CTGF connective tissue growth factor, MMP9 matrix metallopeptidase 9.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of HT to RT significantly increases the pain control rate and extends response duration compared with RT alone for painful bony metastases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carriers of this allele have high levels of MDA, APOB and LP(a), a high APOB/APOA1 ratio and  low ARE activity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increasing esophageal diameter on HRCT in patients with SSc is associated with more severe radiographic ILD, lower lung volumes, and lower DLCO % predicted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, further prospective trials should be designed to define the criteria for stented SWL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As walking is the focus of population-level health promotion, more detailed understanding of the aetiology of regular walking is needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Duration of treatment with cSEMSs should be further investigated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Familial clustering among the husbands relatives demonstrates the fetal genomes importance in genesis of pre-eclampsia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient SES and deductible-level affect physician recommendations for preventive care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: The study was retrospectively registered at clinicaltrials.gov (dated: 25th Februrary.2015) with registration number NCT02376660 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After standard neoadjuvant chemotherapy containing anthracycline, taxane, or both, the addition of adjuvant capecitabine therapy was safe and effective in prolonging disease-free survival and overall survival among patients with HER2-negative breast cancer who had residual invasive disease on pathological testing.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence and intensity of autonomic nervous system dysfunction was similar in patients with burning mouth syndrome and Parkinson disease, which may suggest some similarity in their pathogeneses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relatively moderate rate of attrition could be attributed to the high level of community involvement in the selection process as well as other aspects of the intervention leading to high community approval and support.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A theoretical model of medical learning and behavioural change can be used to devise educational formats that suit different stages of learning.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Along with other known parameters (pleural pH and glucose levels), Karnofsky performance status, size of the effusion, chest radiograph and pleural LDH allow to predict its results and optimize its indications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study results suggest that type 2 diabetes per se or glycemic control is not a risk factor for experiencing postoperative complications in people undergoing dental extractions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Group visits in a pharmacist-managed anticoagulation clinic may provide a safe and effective alternative to individual appointments.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During GH treatment, fT4 decreased significantly to low-normal levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall complication of surgery was 26.7% and resolved without sequelae.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Service providers of programmes should focus on reaching these hard-to-reach groups.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lipid management strategies in primary care should focus on improving adherence to treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we recommend that microbiological investigation upto species level should be mandatory to determine the emergence of non-albicans Candida as a major cause of VVC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To reduce the risk factors of developing CVD and preventing its progression significantly, it clearly serves to underscore the beneficial properties of physical activity and to promote its effectiveness as a support for healthier lifestyles in the community and particularly among military personnel.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Proximal AVF creation in CRF patients with multiple co morbidities should be the gold standard as a primary procedure in terms of better long term primary patency.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term intermittent treatment of facial AD in children and adolescents with pimecrolimus cream 1% does significantly reduce the need for topical corticosteroids.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the results of this study, health coaching improved the QoL of T2D and CAD patients with moderate costs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Internet-based prevention programs for school-age children can improve student's knowledge about alcohol and cannabis, and may also reduce alcohol use twelve months after completion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taken together, our findings support the idea that GABAergic modulation in limbic and paralimbic structures is important during both the response selection and outcome phase of risk-taking decision-making.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Selective serotonin reuptake inhibitors can impair semen quality and damage sperm DNA integrity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genotype could be a valid predictor of tetrahydrobiopterin-responsiveness, since  patients who carried the same genotype responded similarly to the 6R-tetrahydrobiopterin loading test.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regarding comorbid conditions, gluten sensitivity and thyroid disease were found  less frequently than previously reported in the literature.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Economic evaluation of antibiotic prescribing strategies that do not include the cost of resistance may provide misleading results that could be of questionable use to policymakers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endovascular treatment should be considered as a first line treatment for focal infrarenal aortic stenosis and occlusion.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study highlighted the risk factors of breast Ca in women living in Bangui to inform appropriate control measures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most patients with leakage were managed successfully with interventional methods.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The importance of the staggered analysis presented in this study resides in its potential to improve the understanding of associations between determinants and, consequently, the targeting of interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be considered to keep in place extraoral appliances or comfortable intraoral distractors for a long period.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum magnesium concentration of this randomized clinical trial doesn't support the use of the alternative scheme of magnesium sulfate to prevent or treat eclampsia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LNR can be used as an early biomarker for predicting of acute rejection after heart transplantation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The multi-modal early oral nutrition program was an effective way to improve tolerance of oral nutrition during the first week after surgery, decrease the length of stay and improve cost-effectiveness after abdominal surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our technique can be safely and effectively used for SITU laparoscopic bariatric surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Corticosteroids may delay the time of onset of severe skin reactions and also reduce the incidence of severe radiation dermatitis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, the proportion of whole-grain rye to whole-grain wheat intake, indicated by the plasma C17:0-to-C21:0 ratio, was inversely associated with T2D.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Linezolid is an effective alternative to vancomycin for the treatment of cSSTI caused by MRSA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TyG is effective to identify individuals at risk for NAFLD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Copyright \u00ac\u00a9 2016 John Wiley & Sons, Ltd.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum linoleic acid and very-long-chain n-3 PUFAs, partly reflecting vegetable oil and fish intake, respectively, were inversely associated with all-cause mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by the Netherlands Organization for Health Research and Development and others; DRINK ClinicalTrials.gov number, NCT00893529.)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It appears that abdominoplasty in post-bariatric patients requires specific care because of particularities inherent in this population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates the positive effects of state-wide, school-based health promotion on incidental abdominal obesity, at affordable costs and with proven cost-effectiveness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides additional data on the potential role of a life review in improving quality of life, particularly psychospiritual well being; it also indicates that the life review program could enable Chinese patients with advanced cancer to express their views on life and death.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings reinforce the key role of MVPA for childrens health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, goal-directed, individualized intraoperative fluid management with crystalloid should be evaluated further as a component of enhanced recovery protocols following colectomy because of reduced overall fluid administration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A limitation of this pilot study is that it was based on a small study population hence the results should be regarded with caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies with more patients are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-dose chloroquine treatment regimes should be further evaluated with the aim of assessing chloroquine as a potential partner drug to artemisinin derivatives.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A topical formulation of zinc pyrithione can be used to treat localized psoriasis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The adapted FFQ is a reliable tool to estimate the dietary intake of energy, macronutrients, folate and vitamin B12 in women of reproductive age.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the number of ultrasound machines in clinical areas increases, it is important that education programs to support their safe and appropriate use are developed.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, future intervention strategies should target the large percentage of individuals who fail to reach the MVPA goal as result of a lifestyle intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among participants with coronary artery disease, fluctuation in body weight was associated with higher mortality and a higher rate of cardiovascular events independent of traditional cardiovascular risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mesh should only be used in primary cases and, when adhering to the proposed indications, is a safe and convenient option in implant-based breast reconstruction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support EHR-based population health efforts to initiate an  FH cascade-screening model and ensure higher quality care for this high-risk population and identify those who may benefit from advanced therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding has potential implications for the prediction and prevention of NRTI-associated PN, particularly in populations at risk of iron deficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although people with type 2 diabetes may have impaired neutrophil function, the study results revealed that having this condition was not associated with an increased risk of experiencing postoperative complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Special attention is required in such patients while doing treatment planning.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Top quartiles of healthy  eating patterns were associated with lower cardio-metabolic risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first prospective study showing the potential adverse and independent prognostic role of low preoperative LDL cholesterol levels in patients with localized PCa undergoing RP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Quantitative CT is a sensitive method that may be useful in determining alterations in regional adipose deposition in hypogonadal men and in evaluating the benefit of interventional therapy such as testosterone replacement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Chinese patients with CKD, the percentage of hyperphosphatemia is comparable to that of other countries while the usage of PBs is suboptimal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a community sample of individuals using health care, 60% were statin eligible according to ACC/AHA guidelines and two-thirds of these patients  were prescribed a statin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Longitudinal strain curves in the RV free wall reach peak values later in the cardiac cycle and return slower towards the baseline in PHT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Optimized hybrid ESD in the colorectum may offer an easy alternative to colorectal ESD and a rescue method for failed ESD cases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, confirmation is needed in a larger sample, and questions that emerged require further exploration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the effects of the combination of lamivudine and adefovir dipivoxil is the same as single entecavir treatment of hepatitis B cirrhosis suppression of viral replication.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postprandial lipoprotein and vascular abnormalities differ between OH and SCH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prolonged prophylactic antibiotic use after orthognathic surgery may not be necessary, provided that there are no other significant factors for wound infections.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of 11 atherothrombotic biomarkers assessed at baseline, the total cholesterol-HDL-C ratio and CRP were the strongest independent predictors of development of peripheral arterial disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2017;123:841-48.\u221a\u00c7\u00ac\u00a9 2016 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exercise behavior in lymphoma patients 6 months after a randomized trial was predicted by a wide range of demographic, medical, health-related fitness, quality of life, and motivational variables.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that a thrombin-based topical haemostatic reduces the need for blood transfusion in TKR revision surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ultrasound examinations within 2 to 5 years are recommended in every patient, independent of bariatric procedure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early detection and treatment of these two diseases need a better implication and motivation of patients and health care providers.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both training protocols improved muscle strength, but only RTI improved the mobility, motor signs, cognitive impairment, and quality of life, likely because of the usage of high motor complexity exercises.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improved balance recovery ability might be achieved by targeting these muscle groups in falls prevention programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multimedia offers an alternative to a translator for brief explanations, particularly for first-time users, but improving poor co-ordination requires individualised \"hands on\" teaching from health professionals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The grade of the PMP is generally consistent with the grade of the primary neoplasm.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased body mass index is a risk factor for operative, medical, and respiratory complications after open ventral hernia repair.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It appears that the higher knowledge on diabetes did not translate into good practices as over 50% of study subjects did not involve with any preventive measures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower body mass index and  a greater experience of food shortage are closely related to anaemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The robotic-assisted technique tended to improve suturing skills and should be considered as a valuable tool to reduce the technical learning curve.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2018;124:192-202.\u221a\u00c7\u00ac\u00a9 2017 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its therapeutic effect is independent of its effects on sleep, anxiety or depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the basis of the results of this experiment, it can be concluded that 15 ml is perceived as the most comfortable volume.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increasing the ezetimibe dose to 20 mg daily might be an interesting potential approach for patients who fail to reach lipid targets on ezetimibe 10 mg daily along with maximally tolerated doses of statin.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The nutritional course for patients undergoing colon surgery can be improved by implementing early oral nutritional supplements in the PACU.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "National Nutrition & Food Technology Research Institute, Tehran, Iran.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a need to consider the context in which interventions are delivered and implement them in ways that are appropriate to the needs of participants.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Doxycycline should undergo more thorough evaluation as a potential adjuvant treatment to improve the results of EVAR, particularly in certain subgroups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study suggests a role for DHI as an adjunct to CR to improve secondary prevention of CV disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Key determinants of adherence included SES, ethnicity, occupation (farmer) and parity which may be helpful for targeting women for counseling on supplement adherence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight status of intervention participants did not rebound 6 months after programming.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have important policy implications for the dissemination of weight-loss interventions into communities with limited resources.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inter-observer variability in contouring was low.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This would provide impetus for the widespread adoption of 3D planning and IMRT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Administration of glycoconjugate vaccines provides an important alternative method of demonstrating immunologic memory, avoiding the use of plain polysaccharide vaccines that are potentially deleterious in children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Olopatadine 0.2%, which can be instilled less often than olopatadine 0.1%, is a useful new option for allergic conjunctivitis in Japanese patients that could potentially result in better treatment compliance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to accelerating epithelialization, this method shortens the course of treatment and may minimize or remove the need for surgery or other serious sequelae, such as corneal perforation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrated that similar to subjects with DM, subjects with IFG also have IOP levels that are higher than those with normal serum glucose.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the same digital image type and assessment method should be used when examining mammographic density across populations, or longitudinal changes in density within a single population.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with a similar regimen of paclitaxel, docetaxel appeared to increase the DFS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reduction of plasma CETP was associated with mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This research is important because it helps to identify a treatment option for survivors that also may improve access to survivorship services.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide important clues as to the underlying molecular mechanism behind gastric mucosal injury resulting from exposure to LDA in elderly adults, and also suggest that interventions specifically targeting the pathways associated with angiogenesis and apoptosis may help facilitate the healing process.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ITM provides an appropriate alternative to i.v. morphine during major abdominal surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CNBS may be the more appropriate specimen type for immunohistochemical examination of phosphoprotein expression in invasive breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ten years of behavioral weight loss intervention did not result in an overall difference in the prevalence of cognitive impairment among overweight  or obese adults with type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lasofoxifene may be an effective and well-tolerated treatment option for the prevention of bone loss in postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we think that CISH may be an acceptable technique for benign uterine disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Policy decisions on school vision screening in middle- and low-income countries should take account of the cost-effectiveness as well as competing demands for scarce resources.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is therefore encouraged to use a TC during routine cephalometric radiography where SMI information is not needed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We detected MC4R mutations (Thr112Met, Ala175Thr and Gly181Asp) in 3.3 % and MC4R polymorphisms (Val103Ile, Ile251Leu) in 5.5 % of the analysed obese children and adolescents, respectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No material can be recommended as superior in providing a reliable seal after 14 days.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the Latino/Hispanic population, albiglutide resulted in effective lowering of glucose and modest weight loss, and it was generally well tolerated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research is needed to determine the nature, and academic and social significance of this association.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The extent to which bleeding complications occur in nonoperated patients needs to be assessed in further studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: NCT01665378 (https://clinicaltrials.gov/show/NCT01665378).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To the authors knowledge, this is the first study to evaluate discrepancies in number of procedures, revisions, and the proportion of patients  completing breast reconstruction among insurance types.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Partnerships need to avoid the perils of the technological fix, and engage the structural barriers that mediate people's health and access to services.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Standard cognitive-behavioral pain treatment did not yield comparable outcomes for obese and non-obese participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combining eGFR and  UACR level was more accurate in predicting risk of CVD/mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall safety profile during adjuvant treatment was as expected.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results do not support the use of EA in this population of painful neuropathy patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IT dexamethasone might be a good primary treatment method for ISSHL; but, for the management of ISSHL, we should keep in mind the differences in hearing outcomes with regard to frequency.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While the MetSyn score was not related, specific MetSyn components were related to salivary cortisol levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our intervention did not result in a significant improvement in our primary outcome, the proportion of obese and overweight women who had gestational weight gain within IOM guidelines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The establishment of an appropriate framework will effectively contribute to promoting the early detection and reducing the incidence of this disease in the population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that specific parental personality traits can be associated with birth outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unique identifier: NCT01603758.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oncologists need to be aware of this risk if considering crossing patients over from FU/LV to capecitabine-based regimens.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data support MVC as a switch option for ritonavir-boosted PIs when partnered with a 2-N(t)RTI backbone, but not as part of N(t)RTI-sparing regimens comprising MVC with PI/r.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It appears that knees with more severe coexisting PF disease demonstrate features distinct from those observed in TFOA in isolation or in combination with mild PF disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further exploration of geographic inequalities, concentrating on the impact of healthcare, may be warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, cryotherapy should not be withdrawn from such programs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data, conducted in a large population of UF cases and controls, support prior studies that have found a protective association between  diabetes presence and UF risk and is further modified by race.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Those experiencing severe snoring and/or who are obese should be told of what can be done to solve such problems.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that no significant technical advantages exist between the two agents, surgeons should choose a radiopharmaceutical based on cost and side effect profile.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carbitocin is a better alternative to traditional oxytocin in prevention of PPH after vaginal delivery with minimal hemodynamic changes and similar side effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This inverse association can be partially explained by the beneficial effects of physical activity on HDL-C, vitamin D, apolipoprotein B, and hemoglobin A1c.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite an encouraging outcome based on anatomical data in advanced  PDR treated with vitrectomy and SO, the functional prognosis was not satisfying for patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in coupling with visual inspection with acetic acid as a single visit approach, its effect on prevention of HSIL and cervical cancer is still promising.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings provide support for DRD4 variation as an informative predictor of subjective responses to nicotine.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical implications require evaluation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health economics modeling to inform the design of a randomized controlled trial looking at diagnostic technology has been demonstrated to be feasible as a method for improving research efficiency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The treatment with DMF for 52 days as an adjuvant for the conventional therapy was associated with a lower need for major amputations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data support further investigation into the mechanisms of RPL associated with glucose intolerance, but do not support testing for subclinical glucose intolerance in women with RPL.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depending on the type of guidance used, parents are in need of different supporting strategies to enhance positive parent-child interplay.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The finding that defects in autobiographical memory are associated with suicidal behavior in adolescents and young adults may lead to improvements in the techniques of cognitive behavioral therapy in this age group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As in wet AMD, HFs are frequently found in DME and behave similarly under anti-VEGF therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICAL RELEVANCE: Aromatherapy massage is a well-tolerated, feasible, and safe  nonpharmacological method that can be readily integrated into clinical settings by nursing staff.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results suggest the potential benefit of school-based preventive interventions particularly in post-conflict settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as it is likely to be agreeable and beneficial to some service users, perhaps self-help cCBT should be provided as an additional treatment option.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among frail patients or those with multiple comorbidities, over three quarters with low HbA1C did not have their glycemic therapy deintensified,  even after safety concerns were raised in the ACCORD trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings highlight the need for earlier diagnosis and intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether a cholinesterase inhibitor should be used as augmentation in the maintenance treatment of late-life depression depends on a careful weighing of risks and benefits in those with mild cognitive impairment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Internet-delivered self-help parenting programs appear to make a valuable contribution to a comprehensive public health approach to parenting support.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depression was one of the predictors of perceived cognitive decline, but it was not significant for objectively measured cognitive function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Claims that HS achieves small reductions in LoS must be treated with scepticism.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When acetylsalicylic acid was combined with simvastatin treatment, the intraocular levels of Ang-2 and VEGF were significantly lower than in diabetics treated with simvastatin alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data suggest that myoinositol may be useful in the treatment of PCOS patients undergoing ovulation induction, both for its insulin-sensitizing activity, and its role in oocyte maturation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased age is a predictor of complications after bariatric surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although obesity predisposed to an elevated risk of VTE, postoperative mortality and morbidity were otherwise not significantly increased in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fertility-sparing surgery in young patients with BOTs is associated with a good pregnancy rate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results established commercial free-range layer farms as a risk sector for exposure to notifiable AI virus.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A larger trial is needed to confirm the effectiveness of the intervention in the clinical setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, we recommend the use of full spectral radiance light sources for the illumination of Pelli-Robson contrast sensitivity charts.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future interventions in underserved adolescents should enhance opportunities for instrumental support for PA.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PMP technology can be useful in identifying potential biomarkers in patients with COPD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Montelukast may be used as an alternative to low dose inhaled corticosteroids for management of mild persistent asthma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, optimizing vitamin D in early life may be critical for later health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The greater variability and insensitivity to treatment effect for the AAUTa is likely because of the low resolution of its scoring system.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, a significant proportion of patients were detected to have hypertension and dyslipidaemias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of PET/CT to CT changed the management decisions in approximately a quarter of NHL and a third of HD patients, mostly in early disease stages.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Initial viscosity of oatmeal may be especially important for reducing appetite.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A possible effect of pubertal tempo on density needs further investigation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low WH is recommended to reduce biomechanical stress in the shoulder during laparoscopic surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It also reduced the need for supplementary systemic analgesia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the importance of sympathetic activation to counteract intradialytic hypotension, our findings support the use of HD100 in diabetic HD patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "None the less, both artificially sweetened beverages and fruit juice were unlikely to be healthy alternatives to sugar sweetened beverages for the prevention of type 2 diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Clinicaltrials.gov NCT01546727.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High prevalence of MS as well as vitamin D insufficiency and deficiency existed among PMW of Singur block, West Bengal, India.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The data of the literature show data estrogens modulate inflammatory reactions: it is possible that their decrease can produce, at prostatic level, antinflammatory effects improving urethro-prostatic bladder functions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most common medical problems are dermatological, rheumatological complications and minor trauma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this soon after surgery, treatment-related variables showed no significant associations with life satisfaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Frequent measurement of depressive symptoms to identify un/defined CT response trajectories may clarify need for continued clinical monitoring and treatment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study also reinforced the necessity for regular monitoring of metabolic parameters in schizophrenia patients prescribed atypical antipsychotics.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to intervention adherence, weight loss programs should emphasize accuracy in self-reporting.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Small cancers on MRI may need to demonstrate growth to determine need for biopsy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replication studies involving larger population samples are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The D3 receptor may be an important target of neuroleptic treatment of psychosis in AD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laparoscopic cholecystectomy patients in both groups recover equally well, indicating that a greater proportion of LC patients should be offered the outpatient modality.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In an era of increased operator experience, high pressure stent deployment, and reduced anticoagulation with antiplatelet treatment alone, multiple coronary stenting may be performed with a high procedural success rate and good intermediate term outcome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to continue experimenting with web-based resources in order to increase user participation in health care decision-making.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These tools could be useful adjuncts in the prevention of obesity and age-related complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wearing a dental support device may shorten the second stage of labor, and may decrease the number of failures to descend requiring operative intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions that target low-income ethnic and racial minorities may need to focus on increasing participants' satisfaction with information provided on diabetes medications and not just improving their knowledge about medications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are no differences in glycosylated hemoglobin or insulin doses between groups with and without MS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of overall malnutrition in chronically ill children attending special schools was associated with lower subjective health status, especially in younger children and in those with chronic medication usage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The analysis was limited by the small patient numbers, but lipid results were consistent with randomized controlled trials and previous case series.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, it can be concluded that continued use of DMPA may predispose females to the risk of cardiovascular disease in the long run.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some lipid abnormalities increased with worsening kidney function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings could inform health policy, guide prevention strategies, and justify the design and implementation of targeted interventions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present data warrant studies of larger very elderly cohorts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, plasma FA expressed as absolute concentrations may be preferred for ease of comparison and since relative units can be deduced from absolute units.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support current guidelines recommending 2 nucleosides plus efavirenz for initial treatment of HIV-1 infection; adding abacavir as a fourth drug provided no additional benefit.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because it is highly portable, it can be used in clinic settings and the homes of older people as both an assessment and training device.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, there is a direct correlation between fasting serum glucose levels and changes in IOP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings imply that it is not useful to perform a meal challenge in cardiovascular risk stratification.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results further indicate that the model of care may have an impact on families daily living, not only during the initial period of care but for a longer period of time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Epidemiologic implications are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the carer of those most severely affected by advanced cancer, it drew attention to the needs arising from the caregiving role.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Priority should be given to the development of reliable proxy-person versions of both instruments.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data on common risk factors were not adjusted for in the analyses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, in 8.4% of patients with chest pain, life-threatening underlying causes were identified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a clear need for an effective health promotion strategy for  the almost 40% overweight or obese Dubbo YAMs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The meta-analysis demonstrated that the G allele of the SUMO4 M55V polymorphism could be a susceptible risk locus to T2DM, mainly in the Chinese population, while the association in other ethnic population needs to be further validated in studies with relatively large samples.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of 27 patients with partial GHD after pituitary surgery, 40.7% developed severe GHD and 25.9% normalized their GH response.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cite this article: Bone Joint J 2017;99-B:225-30.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "HES 130/0.4 preload reduced the incidence of hypotension, the duration of longest hypotension, and the need for ephedrine during spinal anaesthesia for elective caesarean section.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinicians should continue to monitor and treat pain even after initiating a bDMARD and/or CS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the worldwide development of obesity and bariatric surgery, this study demonstrated that the operation should be proposed to patients with massive weight loss to improve quality of life.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary intake of protein, carbohydrate, cholesterol and energy might be not independently associated with PD risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of herbal remedies was associated with educational level, time since diagnosis, type of surgery use, and use of endocrine therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Altering margin policies to follow either SSO-ASTRO or ABS guidelines would result in a modest reduction in the national re-excision rate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was a significant correlation between pretreatment depression  and pretreatment QOL, nutritional status, and survival outcomes in patients with  HNSCC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Distress responses may serve as a risk factor for use of unhealthful feeding practices among mothers with BE and these responses may increase childrens risk for weight gain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The generic findings of this study have potential implications for the application of peer review throughout the NHS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This first-ever pediatric HoFH statin trial demonstrated safe and effective LDL-C reduction with rosuvastatin 20\\xa0mg alone or added to ezetimibe and/or apheresis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data suggest that antegrade autologous priming is a safe procedure, but an ineffective way for improving biocompatibility and reducing the need for blood transfusion in older patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "VRIA are related to outcome in patients treated with RZB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(1) Thoracic paravertebral anaesthesia can be regarded as a satisfactory alternative to epidural anaesthesia for control of post-thoracotomy pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data provide a novel insight into the potential protective mechanisms underlying simvastatin medication in patients with diabetic retinopathy complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support exercise augmentation of antidepressant treatment as a viable intervention for treatment-resistant depression to improve function in addition to symptoms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the time constraints of family physicians, PIPP should be considered as a preferred, time-efficient method for training medical students that is well received by patients, students, and particularly by physicians.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, these results suggest that lurasidone may be a useful treatment option for patients exhibiting agitation associated with acute psychotic symptoms of schizophrenia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We suggest early proactive consideration of PEG from age 8\\u2005years onwards to prevent  progressive growth failure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This difference must to be considered in further studies as well as in the clinical SHIMP testing protocols.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutrition education with a focus on promoting consumption of khichuri during the third trimester of pregnancy significantly reduced the rate of low birthweight and increased maternal weight gain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With its advantage of providing an on-site diagnosis, endocytoscopy could provide a novel alternative to standard biopsy in routine colonoscopy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CR participants who report higher levels of psychological need satisfaction regarding exercise report greater self-determined motivation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals were unsure of the benefits and risks associated with dietary supplementation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results provide support for the usefulness of TIP as a brief intervention to improve adherence to depression medication treatment provided in primary care settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The resulting smallest detectable differences can be used to interpret future hemiplegic arm PROM measurements with more confidence.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the diagnostic process of spinal VMs, the position of 4D-CTA is the third choice for noninvasive angiography, after dynamic MRA and three-dimensional CTA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risk during 6 months of these adverse events increased with psychological or sedative drug use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings from a large prospective cohort provide evidence that  suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on our study we recommend the use of a short-arm radial gutter splint for initial immobilization of displaced distal radius fractures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We observed potentially harmful changes in cardiovascular risk parameters, markedly  reduced subcutaneous fat and unchanged ectopic fat during TRT and a reduction in  adiponectin levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Being a minimally invasive procedure, it can be tried in patients who refuse or are not systemically fit for undergoing dacryocystorhinostomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it may be used to monitor lifestyle modification to prevent development of diabetes among people with prediabetic conditions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laboratory investigations would offer doctors more information, which translates to enhanced patient care if investigation results are mandatorily accompanied by a laboratory report.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In relation to red meat consumption and risk of OSCC, the future research should center of attention on reducing the complexity of diet and disease relationships and reducing variability in intake data by standardizing of criteria in order to implement simple strategies in public health for recognizing risk groups of OSCC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such initial differences could modulate the risk of cardiovascular events later in the course of arthritis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "That is the case of long survival male breast cancer patient with luminal B subtype and no BRCA mutations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be the ideal size used for medium sized renal stones.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous musical experience could help to identify surgeons whose performance may be specifically affected by music or noise.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some patients on MgP had relapse of symptoms and PC, indicating that MgP is neither a definitive nor a curative treatment for late follow-up.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, screening for breast cancer should start at an early age especially in high risk groups.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The volume of milk was reduced further when antenatal corticosteroids were administered between 28 and 34 weeks' gestation and delivery occurred 3 to 9 days later.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, patients with chronic myofascial pain showed lower intracellular stores of zinc and selenium and inadequate food intake of these nutrients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Initiatives including best practice interprofessional diabetic foot care pathways are recommended with timely vascular management of ischemia, treatment of deep and surrounding infection as well as the availability of foot care and footwear.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SGA, MIS, and MNA-SF had good concurrent and predictive validity for the assessment of nutritional status, but SGA and MIS were likely to perform better than MNA-SF.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women  receiving day-and-night closed-loop therapy maintained glycemic control during a  high proportion of the time in a period that encompassed antenatal hospital admission, labor, and delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disparity exists between perceived and documented emergency department pain management practices for children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This prespecified secondary analysis shows that, when added to usual care, liraglutide resulted in lower rates of the development and progression of diabetic kidney disease than placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further work is needed to examine the potential relation of reverse cholesterol transport and whole body cholesterol metabolism to coronary events and the treatment of atherosclerosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low 25(OH)D may be one of the potential risk factors for developing MS in PMW or vice-versa.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In six multinational trials evaluating bococizumab, antidrug antibodies developed in a large proportion of the patients and significantly attenuated the lowering of LDL cholesterol levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clearly establishing the mechanisms and pathways responsible for this is important for the future, and may allow identification of novel therapeutic targets to promote alveolar epithelial repair in humans with ARDS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depression was a major confounder and may have important implications for future trials on painful DPN.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the pre-testing guidelines for caffeine consumption may not be necessary in habitual caffeine consumers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most of the processed foods had high or medium Na content.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data underscore the importance of appropriate secondary prevention measures to improve long-term clinical outcomes after coronary artery bypass graft surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Registered 06 September 2008, updated 16 May 2012.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ID without anemia is not detected by common screening procedures and is more widespread than IDA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings support the reciprocal effects model of child and family influences on pediatric illness and underscore the importance of early indicators of individual and family functioning.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of mid-term re-interventions after rupture is high, more than double that after elective EVAR and open repair, suggesting the need for bespoke surveillance protocols.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Alnylam Pharmaceuticals and the Medicines Company; ClinicalTrials.gov number, NCT02314442 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 4-yr CombAT data provide support for the long-term use of dutasteride and tamsulosin combination therapy in men with moderate-to-severe LUTS due to BPH and prostatic enlargement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our hypothesis was falsified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The biological mechanism underlying this association is currently unknown.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the use of rivaroxaban as an alternative to warfarin in patients with atrial fibrillation and HF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PHPT is a treatable disorder with good surgical success.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "S. pneumoniae was most commonly isolated, suggesting need for pneumococcal vaccination and effective prophylactic antibiotics.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If efficacious, chromium supplementation may provide a useful, low-cost alternative to or augmentation strategy for selective serotonin reuptake inhibitors, which have partial efficacy in BED.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If we can demonstrate that the use of an ACE inhibitor or a BB can reduce the degree of TZB-induced cardiotoxicity, it is hoped that patients will receive complete and uninterrupted TZB therapy for breast cancer without compromising cardiac function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hand eczema increased significantly more after HDM provocation than after placebo provocation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the largest study of MLL in the literature to date.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus it is important for clinicians to monitor these aspects of functioning when treating this population of patients with schizophrenia with SSRI agents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no differential expression of wound-healing-related genes in cultured primary keratinocytes from burn patients treated with keratinocyte growth factor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, T1773, C1802, G1803, T1846, A1850, and C1858 mutations might have significant correlation with HBeAg nonseroconversion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is recommended that self-report riding exposure questions ask about the hours of riding for the current average week, and data on riding purposes, locations, and experience are also collected.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To conclude, advice to follow LCD or LFD had similar effects on weight reduction while effects on inflammation differed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As PIP&Rofil implants showed shorter retention periods until rupture and ruptured implants can cause symptoms or health problems, PIP&Rofil implants should be regularly monitored and explanted if there is evidence of rupture.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LEVEL OF EVIDENCE: III (Retrospective cohort study), Therapeutic.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-mass breast lesions were successfully and accurately biopsied using cable-free VAB.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Coronary artery disease negatively influences the cumulative patency of vascular access.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results also suggest that once medical cannabis is legalized, factors beyond cannabis-specific beliefs will increasingly influence medical cannabis legalization support.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings support the general recommendations to use multiple educational methods to change physician behaviour.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, further development of CS is warranted as a potential method to prevent HIV transmission and acquisition.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are warranted, incorporating a range of host biomarkers, such as cytohistological, molecular, or biochemical measurements, in  order to address biological consequences of these dietary intakes in human oral health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings provide preliminary support for macro- and microstructural neural predictors of PA adherence and may translate to other health behaviors and behavioral goal pursuit more broadly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence of falls and poor quality of life may be partially associated with the presence of depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The client's personal drinking goals should be discussed in assessment at treatment entry and as a basis for negotiation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SLN involvement did not worsen the prognosis in our cohort.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laparoscopic lavage is a better option for perforated diverticulitis with purulent peritonitis than open resection and colostomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Differences seemed more related to preoperative functional and nutritional status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Negative social interactions and social integration should be investigated in assessments and interventions intended to target caregiver depressive symptom levels.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It improved all symptom domains, especially impulsive-behavioral dyscontrol and anger, and reduced levels of aggression and violence, especially at lower doses (serum levels <350 ng/m).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Simple and cheap media, such as postcards and posters, might help to improve awareness in areas where current knowledge is low.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 6.9% of people categorized as having prediabetes based on  A1c and fasting glucose would be categorized as having diabetes based on 2-h plasma glucose.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The specific fatty acid pattern may be influenced by metabolic, genetic, and dietary factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study has shown the rapid spread of the capsule formulation among methadone users.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further evaluation in a randomized trial enrolling TNBC patients is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results were obtained when the radiologist was simply trying to get tissue diagnosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More studies are needed to determine why nutrition intake is often inadequate and to determine efficient methods for correcting the nutrition status of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide potential new leads for early intervention and prevention strategies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the study results indicate that safety and efficacy were similar irrespective of the diclofenac formulation used; thus, the new SC diclofenac HP\\xce\\xb2CD has an acceptable tolerability profile and may be considered a valid alternative to IM-delivered diclofenac formulations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children with T1DM in The Netherlands are 24 times more likely to develop thyroid disease than their peers without diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In early PD, weight gain was revealed over three years accompanied by an increase in FM and waist circumference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The routine use of nitrous oxide in patients undergoing major surgery should be questioned.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A microphone announcement heard by overhead speakers should be incorporated with other strategies to improve the timeliness of medical assessment of emergent cases.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vitamin A supplementation programmes to reduce anaemia should not be implemented in similar antenatal populations in rural sub-Saharan Africa unless evidence emerges of positive benefit on substantive clinical outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This exploratory analysis indicated a number of risk factors to be associated with increased risk of breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Papacarie(\\xc2\\xae) is an excellent option for the minimally invasive removal of carious tissue, achieving significant reductions in total bacteria, total Streptococcus and S. mutans with the same effectiveness as the traditional caries removal method.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A positive effect of early supplementation with DHA and AA on 20 months attention capacity was indicated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If these results are confirmed, patients with perineural invasion may not be good active surveillance candidates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found a positive relationship between alcohol consumption and breast cancer risk, suggesting that this modifiable risk factor should be addressed in breast cancer prevention programs in Africa.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite continuous access to health insurance, publicly insured women were less likely than privately insured women to receive a preconception consult-an evidence-based intervention known to improve pregnancy outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated HbA1c \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022 6.5% and perioperative hyperglycemia were associated with an increased rate of major complications after abdominal surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the associations with elevated consumption indicate that AUDS reports early in life need to be taken seriously in prevention and intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adequate evidence-based public health strategies are needed to reduce the vulnerability of mothers to food insecurity in LMIC settings and alleviate their risk of a high burden of nutrient insecurity and obesity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Esomeprazole 5 or 10 mg may be used to successfully treat erosive esophagitis and symptoms of GERD in children as young as 1 year.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with Lr-PRP, Lp-PRP improves tendon healing and is a preferable option for the clinical treatment of tendinopathy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The highest risk period, taking into account numerous factors that confound this association, is the latter part of the workday.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Careful assessment of findings as BPE versus NME can improve PPVs, particularly in younger women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Once externally validated, it may be useful for counselling or designing primary prevention studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study are likely to give further evidence to the notion that the generic SF-36 is little or not responsive to small to moderate changes in quality of life in mild to moderate psoriasis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Proper patient selection is an important variable.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help guide the development of an algorithm for the effective use of DCS for augmenting exposure-based CBT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides comprehensive and strong evidence that there are  a number of protective and risk factors for gastric cancer in diet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Decker-system is suitable for the recording and analysis of the correlation between radiologic/physical and microscopy findings, and of the ensuing diagnostic/therapeutic actions. Orv Hetil.2017; 158(28): 1100-1108.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data support the potential for extrapolating analgesic efficacy to other neuropathic pain conditions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, evaluated on the basis of surgical evacuation, the one-day interval could be supported as an option for second trimester medical TOP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional markers detected using metabolomics are likely related to these measures as they did not enhance the overall prediction in a combined model.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overweight/obesity is prevalent among adolescents with T1D, especially among girls and those of diverse race/ethnicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this study reflects real life conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings should be incorporated into practice by intervening to reduce caregiver stress and reduce elder abuse behaviors.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is the first prospective study showing the role of body fat distribution, determined by computed tomography scan, in predicting the natural history of prehypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future investigations should be undertaken on the long-term effects of this technique for the treatment of NCST.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, use of actual body weight in morbidly obese patients appears to be safe.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on serologic tests of a community population for celiac disease, we estimated the prevalence of undiagnosed celiac disease to be 1.1%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed that since ADM introduction to our centre, more breast reconstructions have been of the implant-only type with consequent reductions in the more complex and expensive autologous techniques.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SICS may be the more appropriate surgical procedure for the treatment of advanced cataracts in the developing world.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Lipitor in\\xa0the\\xa0Prevention of Stroke, for Patients Who Have Had a Previous Stroke SPARCL; NCT00147602).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Current Controlled Trials ISRCTN58988083.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surveillance rather than surgical excision may be a reasonable option for patients without suspicious findings at MRI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Presence of GERD may not be considered as a contra-indication for sleeve gastrectomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individuals with apoB higher than predicted by non-HDL-C had significantly higher levels of PAI-1, which may contribute to the increased risk of future atherothrombotic events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a large population of critically ill adults, an association exists between nutrition status and mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Agreement is strong regarding the indications for local RT after PST  and surgery, but less so for nodal irradiation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may aid in the selection of patients not suitable for outpatient treatment and treatment without antibiotics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Head injury continues to be a substantial public health problem.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ulcer grade and severity are also important predictors for healing time, and early screening to assess the severity and initiation of prompt treatment is important.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the potential use of a single ventricular lead for delivery of CCM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many of these safety findings can be attributed to \\xce\\xb3-secretase inhibition, and may be valuable to researchers developing \\xce\\xb3-secretase inhibitors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 2 strongest determinants of obtaining CRC screening were provider influence and patient barriers related to CRC screening in general, pointing to the need for multilevel interventions that target both the provider and patient.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Current smokers are also at risk for systolic hypertension, especially in those subjects aged 60  years or older.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association between fasting TG concentration and IMT persisted after adjustment for postprandial TG response.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Inaccurate BP assessment is common and may impact hypertension treatment decisions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In hypertensive patients, increase in LV mass beyond values required to compensate cardiac workload at a given body size and sex predicts cardiovascular risk independently of age and blood pressure, in the whole population as well as in the subset of patients with LV hypertrophy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with TNBC have adverse outcomes despite aggressive treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings emphasise the need to provide good-quality information on screening outcomes and to communicate this information effectively, so that women can make well-informed decisions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low levels of IgM anti-PC may identify immune-deficient state and predict inferior therapy response.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ileus tube can be used for adhesive small bowel obstruction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative inflammation-based prognostic factors predict early and late recurrence of HCC after curative resection.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results indicate that the ocular knowledge and practices among diabetic patients attending a tertiary-care hospital in Bangladesh is average.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Within the normal range of serum TSH, serum TSH was not associated with BMD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher cord plasma BDNF levels protected against nondiabetic macrosomia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on MRI evaluation, this randomized controlled study proved that EA treatment reduces BMI and WC as well as VAT volume and HFF in women with abdominal obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Counseling in prevention trials should proactively address IPV, for its own sake, and in product and risk-reduction counseling.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Selected cachectic cancer patients may benefit from this experimental approach.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In obese women, the percentage increase of inhibin A can represent an additional marker to recognize follicle luteinization.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical implications are discussed and likewise the need for a more equitable distribution of responsibilities and risk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This trial suggests that telemedicine saves travel costs and results in a shorter healing time than traditional follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Convenience sampling was used to recruit the participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Imaging and other modifications such as cutoff values for APR might increase the specificity of the criteria.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent study suggests that cholesterolosis is somehow associated with metaplasia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased titers of cows milk antibody before anti-TG2A and celiac disease indicates that subjects with celiac disease might have increased intestinal permeability in early life.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications are discussed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this large multinational study, treatment with SGLT-2i versus other glucose-lowering drugs was associated with a lower risk of HHF and death, suggesting that the benefits seen with empagliflozin in a randomized trial may be a class effect applicable to a broad population of patients with type 2 diabetes  mellitus in real-world practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On the basis of these finding, we suggest that the use of drains may not be necessary after the RELIF procedure for the treatment of pilonidal sinus.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The greater adverse  influence of NAFLD per se on HDL-C and eGFR in men compared with women probably related to the gender differences in TG levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This logical, step-by-step process blends theory and practice and is broadly applicable in the context of obesity management intervention development  and evaluation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Retirement offers a time to reassess lifestyle, and adopt positive health enhancing physical activity and dietary behaviours.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laboratory  markers of nutrition can identify patients at risk of unplanned hospital readmission.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, only a small minority of patients was eligible and consenting for the trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Assessment of compliance with consumption should be included when dental efficacy of F milk consumption is being investigated or evaluated to quantify F exposure from milk.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the 95% CI for genetically high plasma vitamin C concentrations overlapped 1.0, which made certain statistical inferences difficult, effect sizes were comparable to those for fruit and vegetable intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, the effectiveness of JUC in preventing CAUTI in a hospital setting was demonstrated in both in vitro and clinical studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chemerin showed positive correlations with potent health threatening components of lipid profile including triglyceride and cholesterol levels in adolescents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study, confirms previous observations that UVA1 phototherapy should be considered among the first approaches in the treatment of patients with severe generalized AD and also demonstrates that in darker skin types, high dose UVA1 phototherapy is more effective than medium dose in the treatment of adult patients with severe AD.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is possible that women already felt supported by their frequent attendance at specialist clinics for monitoring and advice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This overlapped therapeutic lifestyle change method may serve as a cost-effective adjunct and ensure the continuity of high-quality health services  for patients with dyslipidaemia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both methods showed agreement without significant proportional errors regardless of HD frequency and can be used for longitudinal analyses.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adiposity and child snoring are associated with each other cross-sectionally and are each predictive of the other among children/adolescents prospectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NIV combined with RM is recommended after open heart surgery to prevent postoperative atelectasis and hypoxemia.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The imaging findings of sclerosing lobular hyperplasia are not sufficiently characteristic to distinguish the lesion from fibroadenomas and well-circumscribed carcinomas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend antibiotic prophylaxis for patients undergoing a UDS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Penetrating keratoplasty combined with vitrectomy using a temporary keratoprosthesis is a safe and effective method in treating severe ocular injury with blood-stained cornea and no light perception.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improving the blood protein status by consuming protein-sufficient foods such as soy food is a feasible approach for elderly anaemic women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health education efforts aimed at improving HIV/AIDS-related attitudes should not only focus on children but also on parents so that they in turn could assist to improve on health workers' efforts in educating the children.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low Hb level at birth was significantly associated with mortality and receiving blood transfusion in preterm infants born at \\xe2\\x89\\xa432 weeks gestation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An imperfect correlation was observed between whole blood bilirubin measured on the GEM4000\\xc2\\xae and plasma bilirubin on the VITROS 5600\\xc2\\xae.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A more proactive approach to managing this patient population is required to improve outcome.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent changes in mortality distribution highlight current characteristics of pregnancy care in Hungary and may help identify strategies for future improvement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgeries in form of cavernotomy or cavernosa-glandular shunt, when carefully done, are effective and safe.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Progressively integrated sandplay therapy can effectively improve the core symptoms and sleep quality of preschool children with mild-to-moderate ASD, which can be used as an early rehabilitation measure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CFVR impairment, particularly in the presence of epicardial coronary artery disease, follows heart transplantation and is associated with a worse outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These preliminary findings suggest that L-carnosine merits further consideration as adjunctive treatment to improve executive dysfunction in persons with schizophrenia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support the importance of assessing the potential development of NAFLD in schizophrenia spectrum patients receiving antipsychotic medication.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Evaluation of treatment efficacy should address the multiple components of this disease complex; therefore it may be important to consider this composite measure in future trials.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nondiabetic patients who perform higher, yet still modest, amounts of PA following RYGB have greater energy deficits and lose more weight and FM, while maintaining higher skeletal muscle mass.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The two devices can likely be used interchangeably.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although it is a rarely infectious disease, it is important to make leptospirosis known to medical associations in the prefecture and to conduct training workshops and similar activities.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "1) The Aurora 2003 program is used by most of the nurses of the ICU of the Hospital General Universitario of Alicante.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further more detailed studies are needed to find out the effects of drugs on these parameters or to disclose the exact mechanism underlying the alteration of these parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Guasha could be considered as an alternative to some types of recovery from sports training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov NCT01967849.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This exercise programme provided in addition to usual care may assist in the prevention of falls in the subacute hospital setting.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Energy intakes increased with age in children with CF and exceeded that of healthy peers in all age groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "sICAM-1 and sE-selectin are elevated in the serum of patients with IBD but CRP and microalbuminuria reflect clinical disease activity more accurately.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measures including health education, environmental hygiene, water supply and treatment should be taken into account to reduce the high prevalence of H. nana.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intra-abdominal organomegaly was related to  nutritional status independently from renal function deterioration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov NCT02079961.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cancer centers population is older and more adherent to guidelines, whereas the mobile mammography population exhibited greater racial and marital diversity, higher recall rate, and lack of adherence to follow-up recommendations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Scant iron supplementation is likely causative.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Latex SLIT can be used as an effective treatment for latex-allergic health care patients having difficulties in applying adequate avoidance measures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings need replication in other centres.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incident PD patients treated with low GDP solution have less severe systemic inflammation but trends of less ultrafiltration, and more fluid accumulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exercise may be an option for the prophylactic treatment of migraine in patients who do not benefit from or do not want to take daily medication.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our racially and ethnically diverse cohort, cesarean delivery and pre-pregnancy overweight and obesity were associated with childhood overweight or obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depending on the need for anchorage reinforcement, miniscrews can be inserted at the beginning of treatment or when space closure starts.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high and comparable prevalence of posttraumatic stress disorder among patients and nonpatients highlight the significance of the context in which adults with congenital heart disease may face other/additional stressors than disease-related ones, an issue that clinicians need also take into account.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This could be of importance for mammography screening; rather  than unselectively screening all women in a given age bracket, it might be preferable selectively to screen only the high risk group.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When considering studies of higher sample size or methodological quality, false-positive rates and MBM are around 1%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may be more effective to include the assessment of weight and height and nutritional intake in the context of the acute presentation as part of routine clinical assessment rather than relying on screening tools to identify those at risk.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Advances in knowledge: The association of LN with FEA at biopsy was more frequently associated with ADH at surgery than with pure FEA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pharmacist MTM practices and MTM guidelines may need to be modified to affect symptom burden in a population with physical activity limitations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As we move toward wider use of the HMII and other axial continuous-flow devices in both bridge-to-transplant patients and for destination therapy, more studies will be necessary to understand the mechanisms of this obscure GI bleeding and develop treatment strategies to minimize its development.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LDL  cholesterol and triglycerides exhibit highly significant variability; the greatest impact is seen with the triglycerides.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, in ambulatory programmes, especially where there are large numbers of admissions, ceftriaxone should facilitate the work of medical personnel.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, an ASY arm crank configuration should be used to assess anaerobic power in most individuals although specific population groups may require further testing.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The new 10-mg OOD formulation provides sustained oxycodone plasma concentrations over the dosing interval of 24 hours and is suitable for once-daily administration.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Half of the students had the perception that school curriculum inadequately informed them on breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If generalizable to classroom listening skills, these findings have implications for clinicians and teachers involved with children with ADHD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigation is needed on how to better engage retirement village managers in such programs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this prospective study, non-HDL-C and apo B were comparable in their ability to predict risk of future CHD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The SF-36 is useful in assessing functional status in patients with fatiguing illnesses.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings emphasize the clinical importance of lipid embolization in contributing to postoperative cognitive decline in patients exposed to cardiopulmonary bypass.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study confirms many previously reported histologic features and highlights new characterizing features of mucinous perifollicular fibroplasia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to inter- and intra-individual variability in respiratory effects, suvorexant should be used with caution in patients with compromised respiratory function, and at the lowest effective dose.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vitamin K insufficiency was present in 40% and not related to deficiencies in other vitamins or micronutrients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "WA adults are actively reducing the amount of cereal foods they eat  and intake is associated with a misperception of adequacy of intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Binding of anti-dsDNA-containing IgG to MeT-5A cells induces the synthesis of proinflammatory cytokines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dyslipidaemia is common in pre-dialysis CKD especially in female and older patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EVR, ETR and SVR were higher in treated woman than in men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This must be considered when planning elective delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cost effectiveness of health coaching may vary substantially across patient groups, and thus interventions should be targeted at selected subgroups of chronically ill.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biorelevant medium in both USP apparatus 2 and 3 may be used as a tool to predict in vivo disposition of formulations of pantoprazole.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "0.1% FK-506 could become another viable therapeutic option for VKC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum triglyceride, HDL-C, and apoB levels were independently associated with CHD in a Chinese population undergoing coronary angiography with  a relatively low level of LDL-C and a high prevalence of hypertriglyceridemia and low HDL-C.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the fact that GOG 204 also showed statistically significantly improved survival for CP, CP should be considered the regimen of choice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, prefrailty and body mass index were key factors that affected nutritional status in older adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children consumed multiple F/V; however, more whole grains and lean proteins could be provided.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exercise intolerant and activity restricted children experienced larger increases in absolute BMI and BMI percentile than children with neither exercise intolerance nor activity restriction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The model developed can adequately describe the intravenous pharmacokinetics of montelukast and can be used as a useful tool for dose selection in pediatric subpopulations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The available evidence is in favour of weight loss for overweight/obese gout patients, with low, moderate and low quality of evidence for effects on sUA, achieving sUA target and gout attacks, respectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They emerge more quickly after discharge for children hospitalized with asthma or diabetes than for seizures or migraines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the original study was underpowered to properly address long-term outcomes, the results of this analysis suggest that TPVB, administered  whether as a single-injection or continuous infusion during the perioperative period, had little to no appreciable effect on local recurrence, metastasis or mortality after breast cancer surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, if two medicines are used, it is recommended that all dose times are carefully recorded to avoid accidentally exceeding the maximum recommended dose.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although not significant, IR levels decreased over time, which could be indicative of a clinical improvement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study proved that postoperative immunomodulating enteral nutrition should be the treatment of choice in malnourished surgical cancer patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Renal clearance contributes 23% of total clearance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of IRON-HF should help to clarify the potential clinical impact of mild to moderate anemia correction in HF patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings also suggest that treatment monitoring may help to enhance MI\\xe2\\x80\\x89+\\xe2\\x80\\x89BWLP efficacy by guiding a stepped-care approach that identifies individuals for whom additional MI sessions are needed, and when.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Population pharmacokinetic analysis showed that lung transplant patients with CF displayed lower bioavailability and a smaller transfer rate constant between transit compartments than those without CF, while the apparent clearance was faster in CYP3A5 expressers than in non-expressers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were positive associations between lipid profile components and serum chemerin levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results support the theory that in most cases neither DP nor torticollis is congenital, but rather develops and worsens synergistically in early infancy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the levels of MMP-9 and TGF-\u221a\u00e9\u00ac\u22641, factors involved in the breakdown of basement membrane and fibroproliferation, were lower in patients with PDR having simvastatin medication.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They tended to be older, socio-economically disadvantaged, and more fragile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings provide strong evidence that targeting NMDA receptors can be a safe and effective treatment for RTT.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed to evaluate clinical applications of the PA, such as a more accurate identification of malnourished cardiac surgery patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study did not identify a significant DFS or MFS advantage for CT in subcentimetric, node-negative ductal TNBC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These benefits were consistent regardless of patient risk or ancillary treatments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies are needed to better understand the potential role of CA in the local treatment of early BC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of an ACE inhibitor and a statin did not change the albumin-to-creatinine ratio over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modified Jaslow-TLIF technique for the treatment of IS was advantageous for greater safety and efficacy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the present study suggest that the use of validated malnutrition screening tools is associated with better nutritional care and lower malnutrition prevalence rates in hospitalized patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Needed now are prospective studies that integrate measures of the maternal and infant microbiome, and other potentially explanatory covariates, to  elucidate the mechanisms driving this association and to explore whether exposure to vaginal microbiota in cesarean delivered newborns may be an innovative strategy to combat the intergenerational cycle of obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although treatment results are more modest than with liposuction, non-invasive ultrasound treatment may provide an attractive alternative for patients seeking an in-office, nonsurgical procedure for fat reduction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "R/PTAS is a suitable, less invasive alternative to ABF for the treatment of severe AIOD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While VR should be adjusted for non-subjective factors that impact on ovarian visualization, subjective factors are likely to be the largest contributors to differences in VR.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BDNF Val66Met is a determinant of motor skill learning after stroke and could be important for prognostic models.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rather, we found that associations between carotid IMT and CHD risk factors remained stable with advancing age, contrary to the relationship between risk factors and CHD outcomes with age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of external heat increases uptake of intravenously administered Gd contrast into the knee joint, and may help to optimize indirect MR arthrography at a relatively low cost.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The TPB may be a useful model to predict behaviors of physical activity and dietary choice among prediabetic people.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results also support the notion that nicotine increases the risk of type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, 25(OH)D3 interacts with bone formation markers, particularly in subjects with high iPTH concentrations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Native valve endocarditis is the predominant type of endocarditis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LAGB seems to be a good option to treat obese adolescents, as it is  a minimally invasive procedure that does not radically change the patients anatomy and is associated with minimal morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ACC response, like speech and nonspeech perceptual measures, is sensitive to frequency compression ratio.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gain in IGF-I SDS is greater in obese children, and is likely to be related to relatively higher doses of rhGH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence weight-focused treatment approaches can help reduce the economic burden for patients with T2DM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Histology is not characteristic in 25%; hepatobiliary iminodiacetic acid scan and ultrasound may suggest a false diagnosis of biliary atresia in 60% and 28%, respectively, supporting the concept that infants with liver disease warrant early referral to a specialist centre.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, treatment-related factors such as  fatigue had a greater impact on cognitive decline than psychological factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings should be replicated in other intervention studies to further investigate glucose lowering effects and the opportunity to use bitter gourd for dietary self-management, especially in places where access to professional medical care is not easily assured.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Darunavir/ritonavir monotherapy should be considered as a (tailored) treatment option for standard triple-therapy patients who have had a substantial period of viral suppression.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work is needed to improve the design and the planning of these interventions to improve program adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They also indicate that LIBRA may provide a valid fully automated alternative to the more labour-intensive Cumulus.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings underscore the importance of targeting the vulnerability of these patients at an early stage to prevent gait decline in the long run.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides novel information about HLA susceptibility alleles in Norwegian juvenile MG where HLA-DRB1*04:04 was associated with prepubertal onset.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with paricalcitol is effective in controlling secondary hyperparathyroidism in non-dialysed patients with a wide safety margin.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding highlights the potential importance of targeting atherogenic dyslipidemia in diabetic patients with coronary artery disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prompt diagnosis and  anticoagulation therapy led to favorable outcomes in most cases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigations are required to integrate and optimise the  HbA1c as a single, non-fasting, screening tool for GDM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It leads to a sustained improvement/resolution of OAC, and although weight loss is not continuous, it is  maintained over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have important implications for centers without on-site cytopathology services.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Haematuria was not associated with a diagnosis of hypertension or renal dysfunction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Confounding by smoking and coffee/caffeine should be considered regarding the association between fat intake and PD risk in further studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased duration of beedi rolling, advancing age and presence of diabetes were the independent correlates of potential TON.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that use of disease labels may promote overtreatment by causing people to believe that ineffective medications are both useful and necessary.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data cannot therefore support extension of current use of bevacizumab in MBC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Noninferiority in DFS was not demonstrated between the AC-containing and AC-free regimens.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The SISDEP constitutes a promising computational tool for diagnosing and assessing the progression of emphysema in HRCT images of COPD patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, patient selection should be emphasized to improve efficacy of this technique.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides evidence of a dietary difference between male ET cases and male controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even if SpO2 decreases by only 1% during the procedure and its level remains near 100%, physicians should consider the onset of severe alveolar hypoventilation, which requires immediate intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effectiveness of framed health communications depends on the message recipient's current emotional state.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings signify diagnostic value of TDE in the early detection of cardiac effects among patients with type 1 DM.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The  intragastric pressure rise inducing this effect is well\\xa0within the range associated with differing waist circumference and likely to be relevant to the association between obesity and reflux disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of low-dose tranexamic acid can significantly reduce blood loss and need for transfusion, with no increase in complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results identified barriers to PPE use and targets for education to prevent pertussis transmission in ambulatory pediatric settings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the level of participant attrition in the study highlighted a need for further attention to participant engagement with online chronic pain programs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of this genetic polymorphism with ALT levels needs to be studied in other populations with larger sample size.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The new onset GERD detected on scintigraphy may not be pathologic as there is a decrease in total acid production postsurgery; however, it still remains an important issue and needs long-term follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SSE should be evaluated further to improve its feasibility in older adults with type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Solifenacin 5 mg is a recommended starting dose in Korean patients with OAB.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The biological significance of this newly formed layer needs to be elucidated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that it was not possible to enroll the prespecified sample size, these results should not be considered definitive.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with ACL deficiency may need OKC quadriceps strengthening to regain good muscle torque.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found no association between smoking, moist snuff use and future CD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Primary caregivers can recognize severe anaemia (Hb < 5 g/dl) in their children, but only with moderate accuracy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is hoped that  our findings will facilitate establishment of adequate evidence-based awareness and preventive measures for Pakistani women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future programme adjustments should strive to impact more on metabolic control.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These knowledge issues should be addressed by individual physicians and medical societies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This results provide early evidence that antihistamine has a synergic effect with minimizing the side-effect of isotretinoin, and may be used as an adjuvant treatment of moderate acne.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is CBC and biochemical evidence to support the concern that obesity influences laboratory values, even in dogs considered clinically healthy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research on the influence of fruit, milk/dairy products, wine and olive oil consumption on nutritional status is required.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results suggest that recurrent self-injurers are distinguished from both episodic self-injurers and non self-injurers by their greater use of maladaptive defense mechanisms, rather than their lesser use of adaptive defenses.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Childrens dietary fatty acid intake, but not maternal dietary counselling was shown to be related to blood apolipoproteins in children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Acupoint stimulation at Neiguan (PC-6) may be a convenient and inexpensive option (with few side effects) for the prevention and treatment of malnutrition in critically ill patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Monitoring weight, nutritional counseling, and encouragement of physical activity should be considered after eAT for OSAS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, although there is a correlation between serum resistin levels and AP at the time of hospital admission, resistin does not adequately serve as a predictive marker of clinical severity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of PEW varied depending on the tool applied.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Abuse should be taken into account when meeting women with somatization symptoms as patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All impressions from self-reporting were positive such as relaxed,  comfortable, and enjoyable by the aromatherapy group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study portrayed the importance of detail investigation on the causes of bone pain and anaemia in person's aged 40 years and above.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results confirm that APOE variants are associated with obesity in the Saudi population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The problem can be addressed by targeting children since their early ages and by conducting tailored nutrition education to mothers or caretakers to improve the nutritional status of their children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower vitamin D levels are associated with increased cardiovascular disease risk factors and in particular metabolic syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Variation in unexpected complication rates is more likely to be related to hospital rather than patient characteristics in Florida.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetes is associated with an increased risk of hearing loss, and this difference is manifest particularly in adults <50 years old.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two 6-minute walking tests at each time-point may not be necessary.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION NUMBER: ISRCTN42072606.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings suggest indirect examination of occurrence of adverse events should be cautiously undertaken, because indirect assessment of adverse events makes no distinction between what might be simply typical variation in behavior rather than systematic changes in behavior attributable to study condition, and lacks coverage of the full spectrum of adverse events.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the results confirm that the vaccine is safe and suggest that vaccination may have clinical benefit in patients with low HER2-expressing tumors, specifically TNBC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to evaluate whether frailty may improve the estimation of the operative risk of patients undergoing adult cardiac surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Antidepressive drug treatment was not associated with RLS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The low grade of emulsification (12.9 %) in  our patients could not be related to LMWC or cholesterol changes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bivariate LH and testosterone charts are useful in the evaluation of men with known primary testicular failure due to sex chromosomal aneuploidy in whom evaluation based on testosterone measurement in isolation underestimates the prevalence of hypogonadism.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incorporation of careful assessment of the fetal cardiovascular system by sonography certainly increases the detection rate of trisomy 13.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study highlights the importance of providing information in languages other than English and in consumers' native tongue to aid in the quality use of medicines.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These practices can serve as indicators of progressive trends in family centered care.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvements in weight and fasting glucose mediated the decrease in pHDL index.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lunch is in the Bag had significant positive effects on improving communication between the parents and ECE center providers around FVWG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has potential translational implications for the use of reboxetine, which is currently licensed as an antidepressant in several countries, and edivoxetine, a new selective NRI currently in development.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The carbon nanoparticles could be used to identify the lymph node and the parathyroid gland for protecting the parathyroid gland in thyroid surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result could have implications for the prevention and management of cryptogenic stroke.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the largely null findings, a stratified approach that might limit offering CBT is premature; CBT should be offered to all individuals where antidepressant medication has failed.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Safe, feasible, and effective strategies to reduce both HbA1c and perioperative hyperglycemia need to be developed to optimize patient outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a 20-year prospective study of 1339 children with genetic risk factors for celiac disease, we found the cumulative incidence of CDA and celiac disease to be high within the first 10 years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given our finding that patients ON and OFF antithrombotic therapy are both at high risk for stroke in the territory, intracranial stenting trials should not be limited to just those who fail antithrombotic therapy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical features of AGS are not as consistently informative as suggested in the literature.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adding exercise to a short-term weight-loss program should be considered as a useful strategy for achieving clinical control of asthma in obese patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More information on risk-taking behaviors and STIs should be included in diabetes-specific preconception counseling programs, including RGPC.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Person-centred communication is important for the development of the therapeutic relationship during telephone-delivered support.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overnight closed-loop therapy resulted in better glucose control than sensor-augmented pump therapy in pregnant women with type 1 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neuroendocrine changes following treatment may emerge only for specific subgroups, highlighting the importance of exploring treatment moderators.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overall, the findings of this study suggest that important gait and plantar pressure measurements can be reliably acquired.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research on other pathways of this association is strongly recommended.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The percentage of young women with risk factors for breast cancer was found to be alarmingly high.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Text messages can be used to increase FVI in adolescents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, glucose metabolism and fat redistribution do not change over the short term.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increase opportunity of disease prevention can be obtained through better understanding of clinical presentation and risk factors important in the etiology of breast cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study was registered at clinicaltrials.gov (NCT00861731).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the insulation properties of the breast gland, aggressive CA protocols are required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Baseline characteristics reflect a socioeconomically disadvantaged, high-risk patient population in need of evidence-based obesity treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the benefits of the CC system seen with short-term use should be considered when selecting an SCS system.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Well designed prospective studies are needed to further clarify this relationship and its consequences for clinical practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Provided there is sufficient support for the anterior wall and apex of vagina with mesh, posterior compartment repair without mesh may be as effective as repair with mesh for anatomical recovery while providing better anorectal motor function.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dose parameters  were in harmony with protocol regardless original or GS segmentation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oxidative stress could play a role in the pathogenesis of cholestatic chronic liver diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "States of frailty were highly present in the hospital environment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Novo Nordisk and the National Institutes of Health; LEADER ClinicalTrials.gov number, NCT01179048 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This helps to optimize patient care and lowers postoperative morbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data suggests that age and obesity may contribute to the sex-specific incidence of EGFR mutation in lung adenocarcinoma in different manners.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only one of the three methods allowed for the detection of changes from the normal capillary density as early as at the severe nonproliferative DR stage due to several refinements from the basic technique.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CBT and PE can have salutary effects on endocrine symptoms and, to a lesser degree, on sexuality and physical functioning of patients with breast cancer experiencing treatment-induced menopause.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data provide insight into the mechanisms by which rexinoids cause central hypothyroidism and potential ways this effect can be used for treatment of disorders such as thyroid hormone resistance and TSH-secreting pituitary tumors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children with S-ECC appear to have relatively poor nutritional health compared to caries-free controls, and were significantly more likely to have low  vitamin D, calcium, and albumin concentrations and elevated PTH levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, same-statin rechallenge might warrant increased utilization.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Approximately one half of patients with coronary disease do not achieve their target lipid levels as defined in the European guidelines, and this rate is less than reported in previous studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In delayed responders, this may have implications for switching or not switching therapies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical management is required for some complications, but most can be managed medically.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SNP -420C-C homozygozity status seems to be associated with more deleterious metabolic profile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The GSTM1 genotype does not relate with remission and partial remission rates after 1 course treatment of AL patients, but relates with LDH level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on data from this large population of irradiated RC, number of nodes assessed has no prognostic impact in node-negative patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also, given the impressive results obtained with ranibizumab for all types of neovascular AMD, neither PDT nor low-dose TTT should be considered as first-line treatments.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results support the use of regular physical activity as a method for managing state anxiety in young adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study provides preliminary evidence that mothers who consume diets higher in fruit and lower in fried foods and cured meats during pregnancy may reduce the risk of unilateral retinoblastoma in their offspring.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The insulin adjustments are much larger than common recommendations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous breast cancer treatment with chemotherapy, radiotherapy\\xa0or both should be considered when assessing a patients cardiovascular risk profile.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was also observed that mean age at diagnosis is a decade earlier than in western countries.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "s The Ethiopian health care reform has laid the groundwork for health system improvement, but progress was slow and the health care delivery system was still fragile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the exception of reduced bone health, older adults with undiagnosed CD had limited comorbidity and no increase in mortality compared with controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high prevalence of PPV administration in children with SCD diagnosed by newborn screening had a significant impact on the incidence of IPD with improved patient outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This model needs to be tested in  future prospective research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is a risk of thrombo-embolic and pulmonary stenosis complications which needs to be addressed and prospectively monitored.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weight z-score, percent body fat, percent trunk fat, and serum level of interleukin 6 in children with overweight or obesity (Clinicaltrials.gov no:\\xa0NCT02125955).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both of these potential sources were removed, and subsequent active surveillance did not reveal any further cases of M. wolinskyi SSI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to promote earlier HIV diagnosis and treatment and integrating nutrition counseling at all stages of ART implementation may improve  ART outcomes in this vulnerable population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This form of immunotherapy may be an attractive option for some patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum TTR did not show a significant difference by nutrition support  in massively burned patients with >20% of TBSA burned.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may have implications for the significance of these abnormalities regarding prospects in IVF/ICSI treatment cycles.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite access to Xpert, the majority of children with presumptive TB were treated based on clinical diagnosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results support the use of the BITSEA as a tool for child health professionals in the early detection of psychosocial problems in 2-year-olds.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter  (0.78 mmol per liter) and reduced the risk of cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More prospective data are needed to confirm these associations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It can be used as an economical and effective rescue plan.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings also emphasize the importance of the prevention of severe obesity to prevent future-related problems such as hypertension in children and adolescents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevation of perioperative NT-proBNP is a strong independent predictor of postoperative AF in patients undergoing thoracic surgery for lung cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of second generation tyrosine kinase inhibitors led to obtain a complete cytogenetic and major molecular response in fewer time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It could be a good alternative to oral liquid nutritional supplements to counteract protein-energy-malnutrition.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This subset of patients will be the cohort for a prospective study to assess whether collar immobilization is necessary.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding has major implications for use of nursing staff and cost of NH care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, continuing effort and attention are essential as the effect does not persist when intervention ends.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, LE of the primary tumor is recommended when technically feasible.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Registered 15 March 2014.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies on omega-3 and omega-6 intake in relation to inflammatory biomarkers in patients in secondary prevention of CVD are needed, particularly regarding dietary patterns that are rich in some sources of PUFA.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Non-HDL cholesterol is most strongly associated with premature coronary artery disease and could serve as preferred risk predictor and therapeutic target in this young patient population (\u221a\u00a2\u201a\u00c4\u221e\u00ac\u00a7 40 years).", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A relationship between hypercoagulability detected by whole blood thromboelastometry and aggregometry and increased fat mass is shown.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At the doses given, the two amino acids did not affect subjective appetite feelings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients treated with clindamycin and those with a peripherally inserted central catheter had higher rates of unplanned outpatient visits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This provides a molecular mechanism linking oxidative stress and downregulation of channel expression observed in cardiovascular diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This notion may have an impact on self-perception  and dieting behaviour in certain individuals, precipitating and promoting disturbed eating attitudes and behaviour that may lead to the onset of eating disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the results of this study, as well as the opinions of other authors, it can be concluded that the eversion carotid endarterectomy has an advantage over the conventional procedure.We recommend conventional procedure only in cases when retrograde pressure indicates the use of the intraluminal shunting.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Functioning seems to be a mediating factor between positive symptoms and S-QoL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preoperative G8 scores can help forecast postoperative complications in older HCC patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The difference in 30-day outcome was not influenced by the use of different therapeutic modalities, including thrombolysis and invasive coronary procedures, but was rather due to the older age and greater comorbidity of women; these findings seem also to explain the less frequent use of invasive procedures in women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high level of hazardous drinking among people with facial trauma suggests a clear need for alcohol screening and intervention.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aml/Val+HCTZ triple therapy may be a suitable option for patients requiring more than two agents to reach target BP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of resistin with PA was stronger than the association of HDL cholesterol with PA, making resistin a potentially useful biomarker of PA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We should have major policy changes to increase future screening programs and health education programs which would have an overall positive impact on reducing the disease burden.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As such, care should be taken to avoid minor LLD, as it could inadvertently develop on using offloading devices.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Primary surgery with or without radiotherapy may provide a value treatment option for young LSCC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data can be used to inform intervention activities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this pilot study, applying TNP to acute high-risk foot wounds in  patients with diabetes or end-stage renal failure improved the wound healing rate in reference to wound depth.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PAV+ may be used as a useful mode of support in critically ill patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study shows that boiled crude palm oil may have a mild, triacylglycerol-reducing effect in young, healthy individuals and may also show a mild LDL-C-increasing effect in males.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maxillary three-implant overdentures are a viable treatment option for edentulous patients wearing opposing mandibular two-implant overdentures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We confirmed the robust association of MTNR1B rs10830963/G variant with GDM binary and glycemic traits in this Caucasian case-control study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the fact that the quality of life improved significantly after operation, elective repair of symptomatic inguinal hernias should be undertaken as promptly as possible.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: This study used an observational prospective design.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, infants and toddlers, who comprise the main target group in YF endemic regions, and populations with high HIV infection rates, respond to YFV with lower antibody levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional study to determine outcomes beyond 2 years with a bone-anchored annular closure device is warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The consumption of unhydrolyzed milk proteins (56 g/d) for 8 wk improved vascular reactivity, biomarkers of endothelial function, and lipid risk  factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The likelihood of malignancy for a NML on screening breast US was greater than 2%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should determine whether in obese subjects with CTS the weight and waist  circumference loss produces an improvement in CTS symptoms and recovery of distal conduction velocity of the median nerve.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Each 1  mg dL(-1) increase in HDL decreased the odds of severe sepsis by 3% during hospitalization.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Yoga therapy may be used to alleviate anxiety symptoms in cancer patients and should be the subject of further research.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both total extra-oral time and time stored dry are important factors for the onset of resorption in replanted avulsed teeth in children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strength training increases strength in partially paralysed muscles of people with recent SCI, although it is not clear whether the size of the treatment effect is clinically meaningful.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intervention with a fiber-rich diet with brown rice effectively improved endothelial function, without changes in HbA1c levels, possibly through  reducing glucose excursions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies need to be developed to improve OA care, including educating general practitioners in evidence-based treatment recommendations and in the assessment of hand pain, and encourage the routine referral of patients with symptomatic hand OA to occupational therapy before considering surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is quite common but not detectable with fasting laboratory values-the screening recommended by current guidelines.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, revaprazan can be used as an effective drug for acid-related disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reusables may provide a useful alternative to disposable products in certain circumstances.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that appearance should be considered an important motivator for surgery and determinant of satisfaction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The authors postulate that this percentage could be even higher if protocols were initiated to biopsy these  small lesions with larger core biopsies and possibly alleviate the need for formal surgery in these specific, small lesion.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although further investigation of long-term and prospective studies  is needed, we identified four variables as predisposing factors for higher major  amputation in diabetic patients through meta-analysis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, although exploratory and in need of replication, it introduces the possibility that epistasis between the OPRM1 gene and DAT gene might need to be taken into account when examining differential genetic response to alcohol or medication treatment, especially in early-stage alcoholics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to reduce inequalities should consider the influence of education,  income, and occupation in diet to be most effective.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the relatively small sample size of the current study, caution should be taken when adopting the conclusions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This technique was statistically associated with a reduction in the severity of acute-on-chronic lithium poisoning at a given ingested dose and serum lithium level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reviewed studies were heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of dietary cholesterol on CVD risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Iron reduction may be a safe and low-cost alternative to statins.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Worse QOL was correlated with poorer values for FEF 25-75%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "APBI in Japanese women provides satisfactory clinical results except  for cosmetic outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings provide provisional support for the acceptability of the MYLO program in a non-clinical sample although its efficacy as an innovative computer-based aid to problem solving remains unclear.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Parents should be counselled about the risks of pregnancy loss with or without VAS insertion.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These must be started before inserting the LT or a different supraglottic airway adjunct and be delivered continuously during insertion.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measuring personality factors in chronically ill individuals may facilitate targeting of self-management interventions to those most likely to respond.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The vaccine durability supports universal HPV vaccination programs in adolescents to reduce the burden of clinical HPV disease, particularly cervical cancer and precancers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Minor adjustments in management will be needed to accommodate individual preferences to increase satisfaction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intervention-effect among overweight/obese and physically inactive women was, however, dependent on exercise-adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings can be used to anticipate high-risk scenarios and limit AKI in CF patients under clinical care.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, sensitivity and specificity of VAC were under pool for the diagnosis of VAP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ARFI elastography shows excellent correlation with AST/ALT ratios in  obese children and may be used as a noninvasive tool to detect nonalcoholic fatty liver disease (NAFLD) and associated hepatic changes, especially in pediatric patients, for whom liver biopsy is not always feasible.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data inform follow-up practises aimed at optimizing outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the overall fistula rate is not reduced by the coverage procedure, it should be considered as a valid measure for complication prevention due to its clinical benefit.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most plantar pressure measurements were also within predefined acceptable limits; however, reproducibility was not as good for assessment of the maximum sensor pressure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rates of PTMS were comparable between EVR-containing and TAC control regimens.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Overcoming challenges has required a multifaceted approach incorporating individualization, flexibility, and persistence, as well as the ability to implement needed mid-course corrections.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide a breakthrough and initial support for the inclusion of FAP in the workplace along with the integration with brief ACT in individual sessions to improve employees&rsquo; mental health.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with intravaginally applied oxytocin could be an alternative to local estrogen treatment in women with post-menopausal vaginal atrophy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The majority of patients did not comply with their contract and follow-up adherence was low in both groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transanal irrigation may be effective in the treatment of children with FC and renders a high parental satisfaction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypertension was the major aetiology of heart failure followed by IHD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These patterns should be considered by patients and physicians when treatment for lower urinary tract function is initiated with these drugs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical diclofenac is comparable to dexamethasone in providing anti-inflammatory and analgesic effect with the advantage of significantly lesser IOP rise and should be preferred after strabismus surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breastfeeding promotion needs to focus on the health advantages and other advantages of breastfeeding for 6 months, especially in high-risk groups, in order to increase the intention to breastfeed, which appeared to be a strong predictor for actual behavior.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Body mass indices calculated on the basis of stated weights and heights of Playboy centrefolds reveal the majority to be technically undernourished, which is clearly not so on inspection of the centrefolds.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As this study provides new data, the observed effect needs further investigations to better elucidate its extent.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Suboptimal VtD status and bone loss were common in adult SBS even after weaning off PN.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Routine microscopic examination of all LSG specimens is not necessary.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C15:0 is a useful biomarker of dairy fat intake in children and can detect short-term changes in the absolute intake of dairy fat.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Triglyceride was highly associated with suicidality in younger and middle-aged adults, but not in  elderly adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Education and systems for medication review conducted by GPs can be used to improve use of medicines.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sleep is an important factor that physical therapists should consider when teaching clients motor skills.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with nongated F-FDG-PET, the TVs obtained with optimally respiratory gated F-FDG-PET were significantly smaller, however, without a clinically relevant difference in radiation dose to the OAR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it has not been registered as a clinical intervention trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Home-based strategies could be a promising component of poverty alleviation programmes seeking to improve developmental outcomes among rural Peruvian children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This analysis demonstrates the value of observational studies and their ability to provide unbiased results through inclusion of genetic data avoiding confounding, reverse causation, and bias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Persistence of an acute phase response was also correlated with an adverse lipid profile.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite diabetes-specific information recommending birth control and the avoidance of pregnancy, 10% of the study participants became pregnant.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ozone may be considered as an alternative management strategy due to its powerful ability to inactivate microorganisms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ECPC is an acceptable alternative to VPS for treatment of hydranencephaly and near hydranencephaly.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BoNTA may be a useful treatment option for headache patients demonstrating poor compliance, adherence, or AE profile with oral prophylactic regimens.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results underline the importance of a careful observers selection, good initial preparation, as well as the necessity  of ongoing training and supervision over the entire course of a longitudinal nutritional study.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results of the study provide support for cognitive remediation as an efficacious intervention to improve neurocognitive functioning and decrease psychiatric symptoms of schizophrenia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gender (male), duration of diabetes, and diabetic retinopathy may serve as indicators of DN.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of this model will help identify those patients in need of more intensive monitoring and therapy and may help identify appropriate populations for trials of new therapies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gastrointestinal symptoms cannot predict the presence of esophageal dysmotility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Registered on 2 April 2009.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result may be related to the anti-ischemic or to a primary direct effect of the hormone upon myocyte release of the peptide, and may contribute to its anti-ischemic effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In adolescents with T1DM, there appears to be a strong association between intuitive eating, in particular the effect of emotion on eating, and glycaemic control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If validated in other sample sets, Cyr61 may serve as a tissue biomarker for stratifying men for risk of recurrence and thus could inform treatment decision making.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IA TXA is an alternative to IV TXA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For the majority of patients, surgical treatment of lumbar spinal stenosis provides good long-term results and patient satisfaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment of AKI with temporary dialysis in hospitalized patients with baseline eGFR between 20 and 60 mL/min/1.73 m2 was not associated with an increased risk for subsequent admission for MACE.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 4-n-butylresorcinol DMN patch was effective and safe for skin depigmentation through targeting melanocytes and could be a useful functional cosmetic product.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dietary habits with high TAC showed a stronger inverse association with frailty in elderly Japanese women than the individual foods examined.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Country-specific prevalence of diagnosed DR may reflect clinical management of diabetes, healthcare systems, or record-keeping accuracy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a general population of patients seeking hospital based acute care for simple ankle sprains, there is no evidence to support a clinically important improvement in outcome with the addition of supervised physiotherapy to usual care, as provided in this protocol.Trial registration\\xc2\\xa0ISRCTN 74033088 (www.isrctn.com/ISRCTN74033088).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings support the importance of focusing efforts on developing a pattern of regular evening meal consumption among individuals in the treatment of BN.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results support the notion that regulation of little cigars is appropriate in light of public health considerations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although mean weight loss after LGCP was inferior to that after LSG,  especially after six months postoperatively, it was acceptable, and LGCP had an excellent metabolic comorbidity resolution rate in patients with BMIs, ranging from 30 to 35 kg/m\u221a\u00c7\u00ac\u2264.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implementation of RSL can be done with no evidence of a learning curve.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher circulating AMH levels are associated with increased breast cancer risk among premenopausal women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this study should be considered preliminary due to the small sample size.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A structured PA program reduced the risk of MMD even in older adults with extreme obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with severe nutritional depletion or high surgical risk may benefit from mesenteric stenting for CMI, but close follow-up is required.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have implications for the design of rehabilitation techniques for people with AD that may lead to improved quality of life and social interactions for this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Actions focused on improving the methods of preparing meal without gluten were recommended, especially in under populated municipalities with school kitchen on  site.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This meditation program may be useful to manage psychological and spiritual distress, as well as improve quality of life and sleep, in clinical settings among breast cancer survivors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PCB151 was significantly predictive and HCB was significantly  protective for diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The feasibility and tolerability of this treatment produce an attractive new therapeutic option for men with PD.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant weight loss after bariatric surgery is weakly associated with IOP lowering.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Military leaders have recognized the urgent need to support military families.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with craniopharyngioma are at an increased risk for T2DM, cerebral infarction, total mortality and mortality due to circulatory and respiratory diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Common AEs are generally seen within 1\\xa0week of starting treatment, with few subsequent new reports at a given dose.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results from this study support the hypothesis that cholinergic system activity may be important in the cognitive deficits of ADHD and may be a useful therapeutic target.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its presence is associated with increased mortality and morbidity rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Geographical mismatch can be excluded as a reason for this result.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indications of reduced treatment-induced inflammation and thrombogenicity suggest citrate as a biocompatible alternative to acetate in dialysis fluid.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With the prescription of finger splints, a substantial number of potentially positive and negative consequences of their use need to be taken into account.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher intakes of cholesterol and monounsaturated fatty acids may reduce risk of PD in men and women, respectively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Increased familiarity with the environment (not acclimation) could explain the reduced AMS severity on the second hypoxic exposure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This provides support for the conduct of a larger, fully-powered RCT, but with minor amendments to research procedures and intervention components required.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prerequisites for evidence-based practice were assessed as good, but ways to make evidence-based practice time efficient, easy to access and relevant to clinical practice need to be continuously supported at the management level, so that research evidence becomes linked to work-flow in a way that does not adversely affect productivity and the flow of patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cases of refractory diabetic macular edema that did not respond to previous treatment, such as anti-vascular endothelial growth factor injections and laser photocoagulation, exhibited improvements in visual acuity and decreases in retinal thickness after IVD implantation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The addition of ALA/n-3 PUFAs to amitriptyline treatment in patients with VBD/PBS appears to improve outcomes and may allow for a lower dosage of amitriptyline, which may lead to fewer adverse effects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This model can be used to predict DPP-4 inhibition effects of other dosage regimens and be modified for other DPP-4 inhibitors to differentiate their properties.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, future studies should report results stratified by gender and race and should adjust the results by more confounders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "New imaging modalities should allow further exploration of the contributions of choroidal vessel disease to diabetic  eye disease pathogenesis, prognosis, and treatment response.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the importance of the timing of magnesium for neuroprotection for women at risk of preterm delivery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The self-adhesive luting cement RelyX Unicem can be recommended for bonding of ceramic inlays/onlays.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In particular, a low BMI was an independent prognostic factor for poorer survival in the multivariate analysis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may be a better treatment option for moderate and severe sleep apnea patients that is worthy of clinical application.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "They were more likely to have hypertension, high triglycerides, low high-density lipoprotein cholesterol, albuminuria and elevated alanine aminotransferase.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, large tumour size and positive or uncertain margin status were associated with a higher risk of death from breast cancer after treatment for primary DCIS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No differences between these therapy protocols should be expected.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "KC may be helpful in mediating physiologic response to painful procedures in preterm infants.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Acceptance-based procedures may be a viable alternative to traditional CBT techniques in the management of tinnitus.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improved clinical results can be achieved with careful case selection based on specific baseline characteristics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In order to offer residents high quality of care that meet their individual needs, it is important for management and nursing home staff to be aware of and understand factors that enable or constrain change.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Runners should limit weekly training distance in minimalist shoes to avoid running-related pain.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite an overall detectable association in the meta-analysis, considerable heterogeneity existed between studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of a LGI diet was similar to a high-cereal fibre diet on  hs-cTnI and galectin-3 levels in otherwise healthy individuals with T2DM over a 6-month period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only LCD was found significantly to improve the subclinical inflammatory state in type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attenuated hypocholesterolemia signals early risk for late VAP, ventilator dependency, and death.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intravitreal bevacizumab injection was well tolerated and could be used as primary treatment in patients with cystoid macular edema secondary to perfused branch retinal vein occlusion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More clinicians should incorporate hop-to-stabilization exercises into their rehabilitation protocols to improve the deficits associated with CAI.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A qualitative and quantitative OCT-A approach on retinal vascular perfusion may offer an objective and reliable method for monitoring disease progression in diabetic retinopathy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The early results of this WoA Epic pilot trial did not support the suggestion that patients receiving the SJEP, and tissue valves in general, should be administered warfarin to prevent valve thrombosis and peripheral arterial embolic phenomena.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This panel of markers, if validated, can also be a cost effective screening tool for the detection of asymptomatic cancer patients for colonoscopy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of tamoxifen was not significantly dependent on time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, routine use of both ITAs in patients after clopidogrel exposure can be performed with acceptable bleeding complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Iranian Registry of Clinical Trials:IRCT2014092711019N3.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NBCA appears to be a preferred embolic agent.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuing efforts are needed to fully understand the important dynamics of diabetes, adolescence, diet, emotion, and how these factors affect long term outcomes in those with T1DM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings have clear performance implications for athletes, especially for high-intensity, short duration activities and sports.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This paper has implications for future program planners and is intended to assist those wishing to use Intervention Mapping to create similar theoretically-driven, tailored resources.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Endoscopists performing moderate sedation should continue midazolam rather than switching to diphenhydramine in patients who do not achieve adequate sedation with usual doses of midazolam and an opioid.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the minor complications reviewed, the degree of satisfaction of the patients is very high.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study shows promising results for use in ED decision-making for pediatric patients with mental health concerns.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ESP block is easy to perform and can serve as a promising alternative to TEA in optimal perioperative pain management in cardiac surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may have important implications for exercise training in rehabilitation programs and future studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "FNSS may provide some different information regarding patterns of collapse and retroglossal obstruction from FNMM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, these data provide the first  evidence of the role of serum ferritin as a risk factor for hard CHD in African-American and white postmenopausal women in the USA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results also warrant consideration by regulating bodies and public health officers to ensure safe practices.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Women with newly diagnosed breast cancer from mainland China demonstrated particularly low resilience level, which was predicted by hope educational level, avoidance, confrontation, and age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moxifloxacin has an impressive spectrum of coverage and this pharmacokinetic study reinforces its potential as a prophylactic drug against intraocular infections, given the high aqueous levels post topical administration.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rates of both hypersensitivity reactions and grade 3 to 4 hypersensitivity reactions have not substantially changed over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with both pelvic and acetabular fractures that require surgical treatment should be counseled that their risk for infection may be higher.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We need to explore fruit and vegetable intake behaviour further to identify strategies or components that would have made a difference.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to replicate these results and characterize rate of change in serum lipids as a potential biomarker of impending acute cerebral injury.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nutrition label education should be promoted as part of a public health approach to appropriate food choices and better lifestyles to reduce obesity and nutrient-related NCDs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Strategies to improve compliance with PFMT are required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An intervention combining asthma coaching during acute ED visits and a monetary incentive to return for a PCP visit does not appear to increase follow-up with the PCP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It seems that the measurement of placental volume may be useful in IUGR diagnosis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients should be monitored by screening liver enzymes and abdominal ultrasonography in order to detect these side effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In healthy adults, coagulation tests results are irrelevant for the course of tonsillectomy and postoperative bleeding event.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These trajectory groups can be used as a starting point to inform patients and caregivers on the possible prognosis after hip fracture.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the complication rate is very low, this method allows safe and predictable correction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data indicate the iodine requirement in 2- to 5-mo-old infants is 70 \u221a\u00e9\u00ac\u00bag/d.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as 97%  of cancers in our study showed interval change when a prior MR for comparison was available, new lesions or increasing size should lead to consideration of biopsy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RSA may be used for measurement of cartilage wear in hemiarthroplasties of the hip.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it is important to develop comprehensive shammah prevention programs in Yemen.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although preliminary, our results provide evidence for association between the EGF gene and intelligence in patients with major depression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study evaluated transcutaneous capnography as a continuous nocturnal measurement in hypercapnic subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More information on risk-taking behaviors  and STIs should be included in diabetes-specific preconception counseling programs, including RGPC.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMPLICATIONS FOR PRACTICE: Nurses are in a prime position to assess and intervene to alleviate attentional fatigue to improve work ability.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work should evaluate TTP for effectiveness, sustainability and long-term impact in expanded tribal settings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results provide support for interventions targeting childrens SSB intake focussing on the identified family and home-related factors, with active participation of parents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A nurse-led telephone intervention is feasible in primary care and may help to improve patients' health and well-being.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this randomized trial of patient navigation, there was no statistically significant effect on disease-specific QOL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mobile and outpatient unsedated techniques may provide an effective alternative strategy to sEGD for esophageal assessment and BE screening.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated weight and obesity may cause these children significant additional health burdens.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relying on \"inositol help\" to solidify our efforts, seems to be an easy path to help to deepen the effectiveness of its use in all patients still under 40 but with prior failed attempts at ICSI or diagnosed with PCOS or as \"poor responders\".", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may have implications for falls prevention in this patient group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of any aortic clamp decreased and epiaortic ultrasound use increased from 2002 to 2009, indicating a change in the operative technique and surgeon awareness of the potential complications associated with manipulation of the aorta.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "First, if funds are to be expended on service-integration approaches, then, given the lack of intervention fidelity found in this study, policymakers need to insist, and therefore fund a) a well-described practice, b) auditing of that practice, c) retention of family participants, and d) examination of family use and outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efforts to improve outcomes should focus on CV disease and early diagnosis and treatment of infection.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, this technique is associated with high morbidity and reoperation rates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For regular monitoring, only ALP assay is recommended, provided one abstains from repeat injection of vitamin D based on high ALP levels.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative care in these patients is much easier because there is no need for daily irrigation and dressing of the wound.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pertuzumab significantly improved the rates of invasive-disease-free survival among patients with HER2-positive, operable breast cancer when it was added to trastuzumab and chemotherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore both orthosis may be used for the treatment of metatarsal fractures.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breast reconstruction with implants increased patient satisfaction with the surgical outcome, but did not influence patients physical and sexual well-being or their satisfaction with the treatment received.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of the AmnioSense test before considering speculum examination could reduce the number of speculum examinations undertaken, with benefit to women and concomitant health resource savings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study has the potential to guide clinical practice toward innovative modes of psychosocial health care provision.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of CAM is common among patients with inflammatory eye diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If  this association is replicated across larger studies with serial Mg and vascular  calcification measurements, interventions that increase serum Mg and their effect on vascular calcification warrant further investigation in the PD population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the plasma lactate levels were higher in the morning.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "L. reuteri DSM 17 938 at a dose of 10(8) colony-forming units per day in early breastfed infants improved symptoms of infantile colic and was well tolerated and safe.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We do not recommend routine use of arthrodesis with plate and screws in the treatment of women who are forty years or older with stage-II or III trapeziometacarpal osteoarthritis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cervical disc arthroplasty appears to be a viable alternative to ACDF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In children with T1DM, there appears to be a negative association between increased environmental confusion, as rated by CHAOS, and glycaemic control.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend umbilical port for gall bladder retrieval.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, in the context of circadian disruption, multivariable models should be preferred that consider a wide range of polymorphisms, e.g. that may influence chronotype or light sensitivity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Decreased LMW, total, and HMW adiponectin levels are associated with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Long-term studies are required to determine whether these treatments have different cost-effectiveness  or impact on mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Especially the new treatment with ACP can be highlighted as an alternative and as an easy-to-apply therapy option for clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IND/GLY demonstrated superior efficacy and comparable safety compared with its monocomponents, open-label TIO, and placebo and may be used as a treatment option for the management of moderate-to-severe COPD in Japanese patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Twenty-four-mo follow-up data demonstrated that GL-XPS provides a durable surgical option for the treatment of BPO that exhibits efficacy and safety outcomes similar to TURP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Self-monitoring may positively impact self-care behaviors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dabigatran was not associated with a higher incidence of GI bleeding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It appears that surgical resection of malignant lung tumours by lobectomy can also be performed successfully in selected patients with low FEV (1) and COPD II degrees without significant loss of pulmonary function.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this 2-year prospective study in a hospital-based cohort of high-risk hemodialysis patients, elevated CRP, but not raised PCT, was associated with increased mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preventing HF hospitalization appears as an important therapeutic objective in such patients, and a hospitalization for WHF or MI should lead to a careful therapeutic reassessment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrated that TC might decrease fatigue and relieve the anxiety and depression of breast cancer patients receiving chemotherapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Providers should feel confident that both techniques provide equally effective and acceptable analgesia.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, further longitudinal studies are needed to  examine the relationship of insulin resistance and/or surrogate markers to increased rates of NIDDM and CVD mortality in native Hawaiians.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cancer 2017;123:1424-1433.\u221a\u00c7\u00ac\u00a9 2016 American Cancer Society.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Theory-driven, evidence-based strategies for physical activity, sedentary behavior, and dietary intake can be embedded in an intervention using social and mobile technologies to promote healthy weight-related behaviors in young adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recommend the use of this propofol emulsion when considering hemofiltration treatment in this group of patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While not statistically significant in this study, there may be clinically significant increased risks of CAEs and hypoxia for patient with BMI\\xa0>\\xa030 that require further evaluation with larger studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The  degree of tumor malignancy was low in all patients and LSG was the definitive treatment, without recurrence at 5-year follow-up.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical resection with SRS may improve outcomes in patients with a limited number of large BMs compared with SRS alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The impact of false-positive histological diagnoses of breast cancer on unnecessary treatment, as well as that of overdiagnosis, is not negligible and is of importance in clinical practice.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, there is a need to develop treatment strategies designed to interrupt the dyspnea-inactivity-dyspnea cycle in such patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At minimum this study reinforces the need for higher level, structured interventions to tackle the growing public health burden of obesity in the UK and internationally.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinically, KN and FII need to be light cured after placement of these RMGIs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings do not support the use of these antibiotics to prevent exacerbations in COPD patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subjects stabilized BMI z-score and maintained physical activity with further improvement of BP and stabilization of arterial wall remodelling.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Earlier endoscopy was not associated with a reduction in mortality or need for surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings indicate that among individuals with MetS, Chinese men develop carotid atherosclerosis at a much younger age than women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early initiation of EN with currently available energy-rich formulas is insufficient to achieve adequate protein delivery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Impaired renal function and all defined types of renal impairment have been shown to worsen the long-term prognosis of AMI patients treated with PCI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cost of extra sessions necessary to complete the FCU should be weighed against the potential benefit of reducing high-volume drinking when considering adding the FCU to an IMI for this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ClinicalTrials.gov identifier: NCT00438698.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Symptoms develop earlier in patients with triple A syndrome, but the diagnosis is delayed and this has substantial nutritional impact.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The development of effective targeted therapies is essential for this  breast cancer subtype.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinically, the implications of these findings will help to improve, specify, and increase the efficiency of the preoperative workup and counseling of patients with diabetes who need hip fracture surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of arterial hypertension in newly diagnosed type 2 diabetes is high.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intraperitoneal chemotherapy can be used to prevent postoperative liver metastasis of gastric cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions to  reduce indoor air pollution and to promote timely administration of measles vaccination are urgently needed to reduce the burden of severe pneumonia in children in Tanzania.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DRD2 exhibits effects on weight gain from normal weight to overweight/obesity in adults, while, FTO is associated to weight gain from adolescence to young adulthood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that worry symptoms should be a focus of strategies to improve acute and maintenance treatment response in LLD.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postprandial endothelial dysfunction is abnormal only in OH, and this effect does not appear to reflect increased inflammation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physicians' communication skills for frank and clear discussions about suicidality should be developed through various training courses.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results should support allocative decisions of policymakers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It adds to the literature suggesting that abdominoplasties in select  patients may improve incontinence symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Quantitative assessment of patient requirements suggested that besides (tele)monitoring individualized care considering also noncardiac problems should be integrated in efforts to achieve more sustainable improvement in heart failure outcomes.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Measures oriented towards health behavior and psychosocial stress management should be encouraged among parents in order to decrease the risk of overweight/obesity in their children.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among individuals with a history of SAMS, most will tolerate statin  therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pre-operative body mass index was a useful predictor for recurrence and survival in patients who underwent microvascular reconstruction for head and  neck squamous cell cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation It is important to assess psychological factors such as poor pre-operative mental health and pain catastrophising in patients undergoing joint replacement surgery as these factors have an adverse effect on subjective patient outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A negative result would be used to inform the research agenda and contribute to redefining future strategies for tackling obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide additional support for the use of ERRT in treating nightmares and related difficulties and improving sleep.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The new point-of-care transcutaneous bilirubinometer, JM-103 Minolta, demonstrated good correlation with the serum bilirubin measurement in Chinese neonates aged 3 to 7 days.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, combining the data of both groups, significant improvements in HbA1c and BMI from baseline were observed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cell cycle progression test has a significant impact in assisting physicians and patients reach personalized treatment decisions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Combination of pertuzumab, trastuzumab and radiotherapy was well tolerated, which should be confirmed by the results of larger studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "cSEMSs for treatment of ABSs needed less endoscopic interventions to achieve similar efficacy as MPS and might become a new treatment standard.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since this intervention was effective, it should be established in general practice as a means of improving patient knowledge about oral anticoagulation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Emergency and intensive care unit physicians were extremely reluctant to consider intensive care unit admission of patients aged > or =80 yrs, despite the presence of criteria indicating that intensive care unit admission was certainly or possibly appropriate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SLNB prior to NAT is an accurate method of axillary staging associated with a high identification rate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future study comparing results pre and post intervention is needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ours is the first study to investigate genetic variability associated with inflammation, behaviorally related variables, and PCF for BCS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risk was similar to that in smokers, implying that smokers will not reduce their risk of type 2 diabetes by changing to snus use.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ever consuming alcohol and ever smoking cigarette after starting ART, depression, not adhering to ART and being in the second lowest wealth quintile were significantly associated with malnutrition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bupivacaine could be a valid alternative to articaine especially due to its early postoperative pain prevention ability.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, these substitutions could be useful to tackle  the diabetes epidemic.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MTA could be used as a safe medicament for pulpotomy in cariously exposed primary molars and could be a substitute for FC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Pfizer; SPIRE-1 and SPIRE-2 ClinicalTrials.gov numbers, NCT01975376 and NCT01975389 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Preconception supplementation with MM or IFA resulted in modest increases in maternal and infant iron stores but did not impact anemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that post-operative TSH levels were similar in the two groups, these observations are probably due to the correction  of eSCH, suggesting a direct effect of eSCH on body weight regulation and lipid metabolism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While these SLIV programs are effective, to be as cost-effective as practice-based vaccination our SLIV programs would need to vaccinate more students and/or lower the costs for consent systems and project coordination.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that adding social or affective components to physical activity may enhance engagement and retention in activity promotion efforts and their benefits on mental health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This method provides an important technique that can be applied to other developing countries where a randomized study design is needed but infrastructure is lacking to implement more traditional participant selection methods.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Remaining at work also gives a better HRQoL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ANXA2 stromal expression might play a key role in aggressive tumor phenotype associated with increased EMT CTCs release, however, other factors beyond ANXA2 are responsible for coagulation activation mediated by CTCs in breast cancer patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, whilst the design was feasible, this trial has highlighted the lack of clinically and patient-relevant outcome measures that are appropriate for use in this setting for both research and clinical practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies will clarify indications for RT in this patient population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, there is a need for improvement in the current health promotion programmes targeting breast cancer screening.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The CV risk factor reduction is related to the increased level of achieved free T(4) concentration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low newborn birth weight was related to the deteriorated nutritional status in terms of low anthropometric and abnormal biochemical measures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings provide preliminary support for an indoor tanning intervention that engages tanners to challenge their beliefs about the benefits of indoor tanning.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of tolvaptan as an add-on therapy to loop diuretics can be considered an optimal therapeutic option in patients with insufficient response to loop diuretics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Porous tantalum provided a reasonable alternative to bone graft in TTA.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Detrimental safety profile in pooled analysis supports current warnings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study suggests that individuals with high PBF make more impulsive food choices relative to those with low PBF, which could increase the risk of obesity over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Topical insulin is safe for human ocular usage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, that these results would appear to corroborate the concept of increasing physical activity, including aerobic activity, as a preventative measure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eyes with better vision at baseline had a more favorable prognosis, whereas eyes with initial macular detachment, intraoperative iatrogenic break, or heavy SO showed more unfavorable outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated peak postoperative glucose levels were correlated with elevated HbA1c and were independently associated with major complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of a systematic intervention modeling process allows clearer understanding of the next appropriate steps which should involve further evaluation of the interventions using an interactive delivery method in a less selected group of study participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Rising plasma angiogenin levels in pregnancy may reflect persisting placental transformation and remodeling processes: in patients with highly pathologic Doppler flow findings these processes are disturbed and thus placental function is impaired.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hair density and hair thickness of known nonbalding scalp regions showed some differences depending on the severity and the BASP subtypes in East Asian people with male pattern baldness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These waters should be considered part of a healthy diet in order to prevent insulin resistance and cardiovascular disease.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both placental BDNF gene expression and cord blood BDNF were downregulated in neonates with nondiabetic macrosomia compared with normal birth  weight neonates.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the incidence of BIS > 60 are very common in obese patients, true awareness during anaesthesia infrequent in this group of patients  despite the type of anaesthesia, whether intravenous or inhalation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding suggests that both GSTM1-null and GSTT1-null may contribute to the clinical course of T2DM patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is some research evidence that suggests that men and women approach potential drunk drivers differently.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to being above the level of measurement uncertainty, a 20% change in retinal thickness in patients with macular edema seems to be optimal for clinically important changes in visual acuity and may be considered as an outcome for clinical trials of treatments for uveitic macular edema.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides preliminary evidence that web-based computer-tailored interventions can be used to increase physical activity among breast cancer survivors.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Visual outcomes, PCO development over time and need for Nd:YAG laser treatment were similar for the two IOLs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This intervention was successful in improving weight, engagement in strength exercises, increasing levels of moderate-intensity physical activity and consumption of fruit among retirement village residents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The renal and cardiac TOD evolution, as well as the PAIx and CAIx, did not change in either group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is concluded that oral NaAcetate could be used as both an alkalinizing agent and an alternative energy source in the horse.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the microbiological culture results, a specific bacterium responsible for halitosis in children could not be identified and more sensitive methods might be used for this purpose.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results provide initial support for PNC as a model for brief treatment with non-treatment seeking adolescents who are heavy users of cannabis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RELEVANCE TO CLINICAL PRACTICE: In clinical practice, breast-related stereotype threat should be measured together with prevalent symptoms (e.g. anxiety, depression and fatigue) in patients with breast cancer.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study reveals the importance of considering proximity as an important dimension of exercise outcomes-particularly when promoting intrinsic motivation among relatively infrequent exercisers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Either topical tretinoin (0.25%) or retinol (0.25%) can be used safely and effectively when applied in office immediately after SA peeling to ameliorate signs of photoaging.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In extremely premature newborns, incorrect UVC placement is significantly associated with death through its relation to severe periventricular hemorrhage.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Apple pectin may potentially be an alternative to aspirin for the prevention of NIF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both general and central adiposity have causal effects on CHD and type 2 diabetes mellitus.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Universities or colleges could serve as a research platform to evaluate such intervention strategies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this volume reduction impacts cognition and clinical manifestation of the illnesses differentially.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Diabetics and controls exhibited increased adiponectin levels due to  falciparum malaria but differed in response in terms of leptin levels.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disease etiology, baseline factors (NYHA FC, PVRI and SVO(2)) and on-treatment factors (6MWD, SVO(2) and treprostinil dose) were predictors of survival in this study and may be used to aid in treatment optimization.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although further research from controlled studies is needed and despite the presence of other possible confounding factors, monitoring for neuropathy and vitamin B12 and folate levels merits consideration in patients on  long-term treatment with new AEDs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Salt water rinse can be used as adjunct to routine mechanical plaque control for prevention of oral diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sweet solution can be used as a simple and safe method to reduce the distress following immunization in infants up to 12 months.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For Medicare beneficiaries with nonmetastatic breast cancer, residence in regions with higher breast cancer-related expenditures was not associated with better survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The reduction in median and peak concentrations of 1-hpur, which reflects total exposure to, and internal dose of PAHs, was most evident in workers employed in the units where preventive measures had been taken.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CinnoVex can be used as a safe and effective alternative to Avonex in treatment of RRMS.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Public Health Implications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The measurement of serum lactate level was a better marker of oxidative stress among patients with OSAS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, with this cross-sectional study it is not possible to conclude if these  factors play a role individually or collectively or are a serendipitous association, for which large scale analytical studies are required.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The introduction of ART can enhance dyslipidemia, increasing cardiovascular risk, especially among those who have classic risks of cardiovascular disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This may elevate the risk of atherosclerosis, particularly cardiovascular disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future clinical trials should explore the potential of high doses of nabiximols for cannabis dependence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pregnancies in youth with type 2 diabetes may be especially prone to result in congenital anomalies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Physiological and psychological impact of this type of event is still unclear.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The obesogenic effect of p,p-DDE is a major determinant responsible for the association of p,p-DDE with LV mass.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was one of the first studies to examine the number of instability episodes as a predictor of an intra-articular injury.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EVR with reduced-exposure TAC attenuated weight gain at 1 and 2 years posttransplant compared with a standard TAC immunosuppression regimen.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Psychological assessment demonstrated a close correlation between symptoms and psychological factors, suggesting that group psychotherapy is an important alternative to conventional treatment methods.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most of the eyes with CRVO had normal optic disc diameter, but about 25% of patients with CRVO have reduced optic disc dimensions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This appears to be the first review to examine health interventions for tertiary education staff.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of fasting on glucose was small and may not be clinically important.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of asthma was 4.57% and QOL was impaired among the asthmatic obese individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that SLB should be performed in a select group of patients with ILD after discussion by a multidisciplinary panel.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The TruView may be used to elevate the epiglottis for orotracheal intubation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RSL for breast conservation surgery has a low rate of positive margins even early in a surgeons experience.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Visual and optical quality decreases after ortho-k treatment, which can be alleviated by a larger TxZ diameter and a smaller lens decentration.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Awareness about breast self-examination should be emphasized.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Use of the salt substitute significantly reduces the increase in BP over a long term, and thus, the salt substitute can be used as a replacement for regular salt in the daily diet to prevent/diminish the incidence of hypertension.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of multiple diffusion anisotropic indices data provide complementary information to understand the dysfunction of thalamo-cortical pathway in DRE patients, which may be contributors to disorder of language and motor functions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypovitaminosis D was common among patients with a foot or ankle injury seen at our institution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research to identify effective maintenance strategies is required to maximize the benefits of telephone-based interventions on child diet.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that the rs2301436 tagSNP of FGFR10P is positively associated with susceptibility to VKH syndrome in the tested Chinese Han populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although metformin may improve tumour response in the non-randomized, retrospective studies analysed, it may not necessarily confer survival benefits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggested that the increased plasma level of 27-OHC was associated with MCI, suggesting high plasma levels of 27-OHC may pay an important role in the development of MCI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Wheatgrass supplementation at a dose of 3.5\\xa0g per day for a period of 10\\xa0weeks results in significant reductions in Apo B fraction, TC, and TAG without significantly reducing the HDL cholesterol.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the results of this study, an affirmation can be made that meditation can be used as a non-invasive intervention treatment for improving fatigue, anxiety, quality of life, and emotional faculties of women with breast cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesity is associated with increased IOP compared with normal weight controls, but not with the magnitude of postural IOP change across different seated and supine positions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aromatherapy massage is a simple and effective nonpharmacological nursing intervention that can be used to manage neuropathic pain and improve QoL  in patients with painful neuropathy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The method leads to safe, fast and apparently permanent results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on color pattern recognition, it outperforms previous state-of-the-art approaches.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest rare CNVs might have a role in breast cancer susceptibility, at least for disease at a young age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PC\\xa0+\\xa0EC method is more efficient for improving serum lipids and  enhancing health awareness than any single programme in older adults with dyslipidaemia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data may help to understand the mechanisms that trigger ischemic events and to better organize hospital assistance throughout the year.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings demonstrate the utility of this intervention for smoking reduction and maintenance of reductions over time among a population of college students with elevated depressive symptomatology.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The intraoperative use of MMC during PRK did not induce tear deficiency, and it seems that MMC can be used safely when necessary.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, those with T1DM have lower scores for their intuitive eating behaviour compared to controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High mammographic density is an independent risk factor of local and locoregional recurrence but is neither associated with distant metastasis nor survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Work-related psychosocial stress may increase the risk of T2DM only amongst women in their early 60s.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maintained HDL in OH probably reflects reduced CETP activity, which was not observed in SCH.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions on contraceptive attitudes and behaviors should base on the existing health service system, synthesize resources and selectively apply to populations with distinct characteristics.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "FLI could be used as a surrogate of CAP.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This  work highlights the importance of several psychosocial factors in influencing patients surgical decisions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most M3s lacked adequate fluid and electrolyte management competency.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings revealed that girls with PA have higher body weight and height for age values.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High intratumoral PTEN gene expression was associated with poor prognosis in patients with locally advanced breast cancers harboring wild-type TP53.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nebulization with 5% hypertonic saline is safe, can be widely generalizable, and may be superior to current treatment for early outpatient treatment of bronchiolitis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The fact that testing of platelet function at only one time point has reduced significance may have implications for all clinical settings in which aspirin is used for the prevention of thrombo-embolic events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The LA Sprouts program positively affected a number of determinants  of dietary behaviors that suggest possible mechanisms by which gardening and nutrition education act to improve dietary intake and health outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Desoximetasone 0.25% topical spray is a high to super high range of potency (Class I to Class II) steroid formulation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings emphasize the importance of the patient-provider relationship during a clinic visit and help inform how nurses may be incorporated into subsequent screening mammography interventions tailored to Latinas.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This intervention targeting CHWs could lead to desired outcomes for both CHWs and PWID.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While QI implementation may result in staff who are more satisfied with their jobs and who believe they are providing better care, associations with improved care are uncertain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Younger patients have better overall adherence likely secondary to increased parental supervision.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These associations may be secondary to adiposity or insulin resistance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specialist physicians have moderate ability to identify patient negative affect and poor ability to identify patient positive affect and patient satisfaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although self-selection bias was present in our data, it was not likely to be responsible for the beneficial effect in women aged 65-74 at the time of invitation to screenings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association between TG response after a mixed meal and IMT disappeared after adjusting for TGc.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This protocol will save money, time, and workload without compromising patients safety and future management.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients with active ophthalmopathy, teprotumumab was more effective than placebo in reducing proptosis and the Clinical Activity Score.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Risk factors for bleeding can be identified, and knowledge of these risk factors can be used to plan therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study found that children exposed to the Jazan war had more anxiety.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of cholesterol-lowering medication increased substantially over a decade in community-dwelling elderly individuals but was not related to a  change in level or trend following the release of the guidelines and evidence-based data.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The collagen matrix represents a possible alternative to CTG.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biofilm forming isolates and non-biofilm forming isolates had similar infectious outcomes in this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RLS negatively influenced sleep and was associated with depressed mood.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the diagnosis should be considered with the diameter of appendix over 6 mm.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The remaining risk factors specific to sub-clinical and major postpartum depression suggest some differences between women vulnerable to sub-clinical compared to major depressive symptoms in the postpartum period, which may have implications for targeted screening and intervention strategies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the inverse association attributable to these biomarkers is substantial, future research should explore benefits of exercise beyond these biomarkers of risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One month after breast cancer surgery, satisfaction with different life domains was associated primarily with social support and health-related functioning.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found an SVR to reduce overall mortality and risk of death from liver-related and non-liver-related causes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other studies are needed to clarify the potential advantages of the LMA on breastfeeding.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therapy with alogliptin was well tolerated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may inform targeted intervention efforts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sitagliptin might protect \u0152\u2264-cells in the pancreas by elongating the telomere length.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings might be used by providers and health systems to promote healthy lifestyle changes for their patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The presence of PU is also related to adverse outcomes, such as MV duration and ICU and hospital mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For those identified to be at high risk, providers must then either engage in chemopreventive counselling or refer patients to providers who are more comfortable working with patients on  this critical decision.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The initial negative nitrogen balance can be increased by more aggressive feeding regimes than the usual ones.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with testing using the Carpenter-Coustan criteria, the IADPSG criteria for diagnosis of GDM were associated with higher rates of GDM, cesarean delivery, shoulder dystocia, and neonatal intensive care unit admission.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of NSAIDs was not associated with more diarrhoeal symptoms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMPACT: These findings, coupled with evidence that statin use is associated with  reduced recurrence risk, suggest that lipid levels should be explored as a modifiable risk factor for prostate cancer recurrence.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fast-track anesthesia combined with morphine-clonidine spinal analgesia controlled postoperative pain better and obtained a better QoR than conventional analgesia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further work is needed to understand how weight management programmes can be delivered effectively to young people from diverse and deprived backgrounds in which childhood obesity is common.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In most cases, such findings can form the basis of the diagnosis, eliminating the need to perform a lung biopsy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings provide preliminary support for the integration of an SBIRT model in an HIV/AIDS clinic setting to screen and provide active treatment to all smokers, regardless of readiness to quit smoking.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Up to 43% of patients undergoing shoulder arthroscopy can be classified as obese, but early perioperative complications are uncommon.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Study results supported RNs' unique contribution to resident outcomes in comparison to alternative nurse staffing in fall prevention, decreased use of tube feeding, better range of motion for residents, and decreased aggressive behaviors in nursing homes in Korea.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Through meta-analysis, we were able to gain insight into previously  reported associations between +331G/A polymorphism and breast cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The common Ala-87-Thr polymorphism of the P2Y11 receptor is associated with AMI and increased levels of C-reactive protein.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Stent diameter might be important for stent patency in procedure with PES for SFA lesions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results in this trial did not highlight any differences between  those who received the intervention and those who received usual care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, its role in the prevention of endometrial hyperplasia and adenocarcinoma as well as its effect on risk of breast cancer recurrence remain uncertain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "But the tendon-bone suture without tension is then often possible only with musculo-tendinoplasties.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research should consider organizational readiness as an important factor of change and ultimately of the quality of care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Men appeared more susceptible to T2D than women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The bidirectional association between AN diagnosis and CD warrants attention in the initial assessment and follow-up of these conditions because underdiagnosis and misdiagnosis of these disorders likely cause protracted and unnecessary morbidity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In preschool-age children, an intensive 6-month behavioral skills-based intervention is necessary to reduce obesity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GNRI could identify patients with high risk for amputation in early time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings do not provide evidence to support routine metronidazole treatment of D. fragilis positive children with chronic gastrointestinal symptoms.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No significant differences in weight gain, growth, or nutritional status were observed at hospital discharge between the two feeding strategies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Parents and health professionals can confidently use these techniques to reduce the short- to medium-term burden of infant sleep problems and maternal depression.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More study is needed before recommending weight loss, in particular rapid weight loss, among men with prostate cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A data monitoring committee should be considered in the design of clinical trials involving behavioral interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The malnutrition diagnosis of patients submitted to abdominal surgeries is associated to greater risk of post-operational complications and longer hospitalization permanence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Healthy behaviors, including engagement in exercise, proper diet, especially comprehensive lifestyle behavior interventions, should be valued in improving HRQOL of BCS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Phenotypic heterogeneity and relatively small sample sizes may explain the lack of genome wide significant findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the implications that this knowledge gap has on military and civilian prehospital reservoirs of infection, further study is warranted to confirm these findings and identify targets for preventive intervention throughout civilian disaster and military casualty evacuation chains.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the doses per kilogram of weight administrated may have had an impact on the metformin effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In our nationwide case-control study, we found no association between statin use and risk of endometrial cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Its analysis facilitates the evaluation of cardiopulmonary bypass modifications as the minimal extracorporeal circulation system could be proven to be less injurious to endothelium and myocardium.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings warrant effective treatment modalities to reduce the occurrence of oropharyngeal candidiasis.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dilute sodium hypochlorite may represent an efficacious, safe and affordable antimicrobial agent in the prevention and treatment of periodontal disease.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obesitys effect on HeRO catheters has not been amply addressed; therefore further prospective studies are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present analysis shows that LopiGLIK\u221a\u00c7\u00ac\u00c6 may represent a more effective tool for clinical management of CV risk factors in subjects with mild hypercholesterolemia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the reverse association was not found, MDD-R tends to be also associated with subsequent development of obesity, but larger studies  are needed to fully assess this issue.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mifepristone may offer an effective treatment option for women with uterine leiomyoma and the associated pronounced uterovaginal bleeding.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PCP beliefs about mammography effectiveness and screening recommendations are only modestly associated with use, suggesting other likely influences on patient participation in mammography.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intramuscular monthly neridronate represents a convenient treatment option for patients with RA using corticosteroids.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When the duration and severity of sleep problem meet the standards of Sleep Questionnaire, a physician should be aware of possible depressive and anxiety disorders and more detailed information should be collected.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most research has yielded mixed results regarding the efficacy of contracts in improving health outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We could not identify reliable clinicopathological risk factors which could predict results of SLNB in thin melanomas.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Collaborative care is a potentially cost-effective long-term treatment for depression in patients with comorbid physical and mental illness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Providing primary health-care units with training, support and financial reimbursement for delivering Alcohol Use Disorders Identification Test-C-based screening and advice to heavy drinkers increases screening for alcohol consumption.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The burden of gynecomastia among men on ART in Malawi was higher than previously reported, and was associated with adverse psychological consequences, calling for increased awareness, a proactive diagnostic approach and diligent clinical management.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Energy intakes were unable to meet the clinical demands of children in these age groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It should be studied further to strengthen and clarify these results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination of a low to intermediate pretest probability with a negative PIFA test can rapidly exclude the presence of platelet activating anti-PF4/heparin antibodies and, therefore, HIT as the cause of the thrombocytopenia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A 12-week high-intensity exercise intervention with high energy expenditure can considerably reduce body weight, body fat, WC, WHR, and WHtR, whereas a light-intensity exercise intervention can significantly reduce body weight and body fat.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the conclusion that HX575 and epoetin beta will be equally efficacious and may be interchangeable as therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DM should be taken into account cautiously in the management of patients undergoing hepatectomy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12613000607774.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this pilot trial of a weight loss intervention provide preliminary support for using a smartphone application for self-monitoring as an adjunct to behavioral counseling.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maternal dietary vitamin D beneficially programs intestinal permeability and systemic LPS concentration, which is accompanied by stronger trabecular bone in an obesogenic environment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intramuscular olanzapine 10 mg was shown to be generally safe and tolerable, and could be a new option for treatment of schizophrenia in Japan.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Products containing St John's Wort should not be given to patients with hypercholesterolemia who are on treatment with simvastatin.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Placebo effects should however not be ruled out, since sham stimulation also led to improvement on a number of AVH parameters.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, a careful gross description is still necessary in certain cases for potential future medicolegal implications.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It provides a novel methodology for describing weaning in an at-risk pediatric population that may be helpful in future research on weaning strategies to prevent iatrogenic withdrawal syndrome.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efforts to improve long-term outcomes of older patients with major depression and/or dysthymia should focus on providing more intensive treatment and follow up for patients with residual depressive symptoms.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Decision making in prehospital end-of-life care is a challenge for all paramedics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LTA has a lower risk of brain embolization because of the lower number of catheter exchange maneuvers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies encompassing larger groups are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, they need more assistance from the health care institutions and community, including policy makers, so that they can cope with their caregiving activities.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even though the majority (77%) had moderate or above moderate knowledge on diabetes, their attitudes towards diabetes was poor (88%).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "None the less, both artificially sweetened beverages and fruit juice were unlikely to be healthy alternatives to sugar sweetened beverages for the prevention of type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The application of 1% MBD as a single technique in breast cancer SNB has favorable identification rates and predictive values.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov: NCT00197730 and NCT00421668.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, clinicians might be able to monitor PCa patients who have a high risk of development of arterial stiffness after ADT administration by referring to LDL-C/HDL-C levels.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In order to detect 95% of 1-cm inferolateral arthrotomies of the knee with use of the saline solution load test, 155 mL must be injected.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A longer treatment regimen with silibinin (alone or in combination with other agents) should be assessed in clinical trials for the prevention of hepatitis C recurrence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For IATS patients up to 12 months of age, cataract surgery coupled with IOL implantation and spectacle correction was 37.5% (\\xe2\\x88\\xbc$4000) more expensive than cataract surgery coupled with contact lens correction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found a good agreement between  the methods.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, our results did not support its use solely for improving oxygenation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CMVIg monotherapy prophylaxis was effective in R+ patients with ganciclovir-related toxicity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we concluded that tramadol can be used as an alternative drug to lidocaine in local anesthesia and has the ability to decrease the demand for post operative analgesics.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with COPD are less active than are healthy adults of a comparable age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following pediatric inguinal surgery, ilioinguinal block provides more effective analgesia than the TAP block.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the potential use of l-THP for the treatment of heroin addiction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that mannitol can be used to induce good-quality sputum, useful for analysis of inflammatory mediators and for predicting the inflammatory phenotype in asthma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whey-protein supplementation also lowered 24-h ambulatory SBP and DBP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, poor developmental outcomes were observed, despite increasing the intake of natural proteins.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The frequencies of CETP gene -629 genotype and allele in the Tianjin  Han Chinese population was significantly different from that in Other domestic and foreign populations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Training to volitional fatigue might be necessary to obtain optimal results.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that extreme high\\xa0fiber intake may be associated with decreased risk of breast cancer but the level of dietary fiber intake among Japanese population might not be sufficient to examine the association between dietary fiber intake and breast cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings point to the importance of tailoring interventions to address affective, knowledge, and cognitive skills when intervening to reduce DD and improve glycemic control.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attending conclusive results from ongoing studies, everolimus and exemestane should not be used routinely in male metastatic breast cancer patients, but taking into account for selected cases.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implications for Rehabilitation Spiritual beliefs can contribute to quality of life and may help moderate depressive symptoms that accompany chronic illness and disability, suggesting that rehabilitation professionals should address spirituality in working with their patients with spinal cord injury (SCI).", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LOHS and IHM were also higher among RHA patients with diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CD40L, more than IL-6, or TNF-\u221a\u00e9\u00ac\u00b1, constitutes a predictor to explain PCOS and associated features.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Currently available evidence does not support negative pressure wound therapy use among obese women for cesarean wound complication prevention.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore SR is a well-tolerated agent that can be used alternatively in the treatment of LUTS due to BPH.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Low socioeconomic status is associated with higher levels of mortality and morbidity for adults with type 1 diabetes even amongst those with access to a universal healthcare system.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The positive effect on DHLS scores suggests that animation has great potential for improving diabetes health literacy among Latinos having limited functional health literacy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions in early life should focus on optimizing linear growth while minimizing excess weight gain and environmental enteric dysfunction.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All patients who undergo BCS should receive RT, even with complete pathologic response.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MISC was effective in teaching Ugandan caregivers to enhance their childrens cognitive development through practical and sustainable techniques applied during daily interactions in the home.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ClinicalTrials.gov Number: NCT00570102.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Changing childrens dairy food choices to reduced-fat varieties did not adversely affect overall food intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adolescents with high risk factors, especially those with menstrual disorders and hyperandrogenism, may need careful clinical screening.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high prevalence  of some of the risk factors of stroke such as diabetes mellitus indicates that policy and advocacy to drive changes in lifestyle are necessary to reduce the incidence of stroke and its consequent burden on health systems.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As novel associations we report the minor, G allele of the rs7578326 SNP in the LOC646736/IRS1 region as a significant and the rs13266634/T SNP (SLC30A8) as a suggestive protective variant against GDM development.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Herbalife NC membership was positively associated with perceived health and measured cardiometabolic benefits.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We showed for the first time that sensitivity to thermal pain in women is dependent on DHEA-S and on cortisol/DHEA(S) ratio in patients with AN.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings suggest that more investigation may be necessary to determine if 5-HT3-receptor antagonists are suitable treatment options for opioid withdrawal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To our knowledge, this is the first study to investigate the reproducibility of several biomechanical methods in a heterogeneous cohort.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower dialysis dose with lower daily protein intake can achieve a lower-level nitrogen balance and does not lead to malnutrition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the high prevalence of musculoskeletal pain within populations, it may be worth considering further the mechanisms that explain partner concordance.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective studies are needed to determine whether nutritional optimization can prevent significant WL and improve outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After 10 years of randomised treatment, women receiving hormone replacement therapy early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, without any apparent increase in risk of cancer, venous thromboembolism, or stroke.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is room for improvement in the use of self-help through increasing the usage of strategies that are likely to be helpful and reducing the use of strategies that are unhelpful.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significantly more patients in the saline group required administration of catecholamines for circulatory support.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This paradox refers not only to 30-day overall mortality but also to 30-day cardiac and respiratory complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fat grafting seems to be a safe procedure after breast conservative treatment for breast cancer patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time  for those who practiced TYP at least 2 times a week.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hence, incorporation of metformin into standard clinical  care would offer a therapeutic option for the prevention of TB.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A larger and methodologically rigorous study is called for to further elucidate this finding and specifically determine the benefits of targeting EA with interventions such as ACT, in conjunction with evidence-based BFIs.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Care must be used when applying the AS criteria generated from one population to another.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Readmission disparities behave differently across chronic conditions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that mulberry leaf extract may be a useful complementary mealtime glucose option for patients with DM2.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study is the first to document amelioration of urinary incontinence symptoms in massive weight loss patients undergoing body-contouring  procedures.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cholestasis remains an important complication of parenteral nutrition, and several clinical and biochemical factors may be helpful in identifying high-risk patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With negative MRI findings (BI-RADS category 1, 2, or 3), the risk of malignancy is less than 4%.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depression at ages 78 and 85 is consistently associated with increased ER visits and should be considered among older people presenting to the ER.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "About half the patients with hyperlipidemia were eligible for treatment with drugs to lower it.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We think that nutritional interventions can be inexpensive,  safe, easy to administer and generally acceptable to patients with postadolescent acne.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The observed DNA damage could be associated with the hairdressers' occupational environment, where different chemicals are chronically manipulated and inhaled.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study supports that important risk factors for PD are very young age group (especially under 1 year old), lack of breastfeeding and malnutrition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No conclusion with regard to the differential effectiveness of both interventions could be drawn.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both PRP and HA injections improved the clinical outcomes of patients who underwent operation for talar OCLs in the midterm period and can be used as adjunct therapies for these patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The problem of consumption of less healthy foods is complex and multiple factors need to be considered by health practitioners, social marketers and parents to address the issue of childhood obesity.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "profiles without safety concern raised.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to tailor MST specifically to meet the needs of juveniles with high levels of callous/unemotional traits and high levels of narcissism to obtain the same level of effectiveness as with juveniles scoring lower on these traits.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings indicate that the G8 score, based on patients nutritional assessments, is a useful screening method for older HCC patients who  qualify for elective liver resection.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Individual symptom resolution rates were highly variable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our trial suggested that the effects of cooking classes focussing on salt reduction for housewives could be transferred to family members (UMIN-CTR: 000018870).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although artificially sweetened beverages and fruit juice also showed positive associations with incidence of type 2 diabetes, the findings were likely to involve bias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given that the risk of lymphedema after ALND ranges between 20%-53%, the morbidity of ALND may far exceed the likelihood of detecting further nodal involvement in women with micrometastatic disease: 7.1% in this series.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Factors associated with positive margins after lumpectomy included poor histologic grade, LVI, and EIC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Electro-acupuncture may reduce immunologic damage caused by chemotherapy, thus it can be used as the auxiliary therapy for patients undergoing chemotherapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Between 2005-2006 and 2013-2014, the prevalence of chronic conditions increased across all segments of the childbearing population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum 25-hydroxyvitamin D concentration \u221a\u00a2\u201a\u00c4\u221e\u00ac\u202274\\xa0nmol/L was associated with a 60% lower risk of bladder cancer incidence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Under the assumption that intake of olive oil in the dose provided here was inert, our results support that increasing n-3 PUFAs in late pregnancy may carry an important prophylactic potential in relation to offspring asthma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Real-time MRI guidance during insertion of interstitial needles followed by 3D-planning maximized opportunities for tumor targeting and sparing of normal tissues.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The developmental trend of accommodation and vergence differences and significant differences in cut-off between the current data and available literature are reported.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversational agents can be used to improve accessibility to Web-based searches in general and clinical trials in particular, and can help decrease recruitment bias against disadvantaged populations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Analyses by time to diagnosis indicated that citrulline may be a marker of subclinical prostate cancer, while other metabolites might be related to aetiology.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RS has an 'active ingredient' (craving reduction) and its effects on smoking cessation may merit further examination using modern rigorous methodology.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both serum UA and lactate were positively correlated with the degree of hypoxia in OSAS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, because the effects decrease over time, efforts should be made to maintain the effects through regular interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, alteration in serum level of leptin was obviously different in infertile men in terms of overweight and obesity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The sampling procedure led to similar groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with the Q allele of the PON1 Q192R polymorphism who were treated with statins exhibited improvement in glucose metabolism, especially in insulin secretion, suggesting the importance of genotyping PON1 Q192R to identify those who could benefit from statin therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further research is needed to define appropriate protocols for vitamin  D testing and supplementation in practice to see if this can improve cardiovascular disease risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Implementation of worksite yoga and workout facilities and minimal fruit interventions should be considered by employers to promote transitions into healthier lifestyles and thereby health.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Alterations in LT and ACD sufficient for a unit of refractive power change during accommodation might be smaller than previously thought.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When comparing with Traditional Chinese Medicine (TCM) syndromes of asthenia nature, such as YDS, QYDS, and heart qi deficiency syndrome), the levels of TG, TC, and LDL-C were higher in phlegm turbidity syndrome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "the ABCD rule can be used to train patients, above the age of 17 years, to identify changes that suggest melanoma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intraoperative prophylactic tranexemic acid use is a simple and economical option for effectively reducing staple line bleeds leading to significant decrease in operating times.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was not any statistically significant difference found in the other observed factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health and eye-care practitioners need to expand diabetic health education and promotion among diabetic patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Depression, functioning and family variables impacted on QoL, and need to be considered in terms of ongoing patient management.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gradients in the determinants of overweight persisted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions focusing on improving these  variables are required to confirm the findings of this study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Little covariation was detected within or between other diet, physical activity and sedentary behavior domains suggesting that interventions to improve these behaviors in adolescents need to include specific program components for each target behavior of interest.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As in previous outbreaks of culture-proven AK, contact lens use was the major risk factor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar coaching interventions should focus on early and frequent contacts to achieve intervention goals, recognizing that parents of children with less severe disease and who have more social support may be more difficult to engage.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar assessment approaches (food, dietary supplements, and biomarkers) should to completed with other nutrients of concern for the female athlete.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Early treatment response  directly correlated with overall change in BCVA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients on HIST had the lowest likelihood of presenting with STEMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mechanisms responsible for these observations remain to be elucidated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study highlights the significance of body composition analysis in medical practice, improving prevention and alleviating later health-related economic burden.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Even 6 months after acute pyelonephritis 72% of dimercapto-succinic acid defects improved, demonstrating that some of the lesions may be not definitive.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the use of high flow rates should not be considered a drawback for CM administration in clinical practice.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More attention should be paid to patient education and to communication between patients and health professionals regarding pain and pain management.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participation in regular wheelchair basketball sport may preserve and augment functional abilities in with wheelchair user Implications for rehabilitation The skills-sports relationship is reciprocal.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low preoperative PA is an indicator of malnutrition and determines  adverse outcomes after cardiac surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DBT and FFDM mammograms more frequently include posterior or lateral  tissue, the inframammary fold on MLO views, the pectoralis muscle on CC views, and skin folds than FS mammograms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health practitioners are keen to provide preconception counselling and reported knowledge of evidence-based guidelines.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Altered taste perception was common among prevalent hemodialysis patients and was independently associated with poorer indices of nutritional status and increased all-cause mortality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that nutritional screening tools have poor sensitivity and are difficult to interpret in the acute setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests that ghrelin regulates substrate utilization and may promote metabolic flexibility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies may improve the understanding of the relationship between thyroid function and metabolic changes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The respective advantages of each test should be balanced when referring symptomatic patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One in every four adolescents residing in Jeddah was obese, with a high obesity prevalence in boys and in children attending private schools.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Children with ASD have an increased risk of obesity and obesity-related metabolic disorders.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of the thermal suit is a good alternative to conventional measures of warming in reducing heat loss during surgical procedure under regional anaesthesia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lumbar disc prosthesis offers a possible alternative to lumbar arthrodesis for the treatment of severe disc degeneration at one level in the young subject.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions such as this could improve patient care and may be applicable to other practice settings, as well as other types of tests.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Given the low awareness levels among women currently, these findings suggest that appropriate education materials have the potential to greatly increase knowledge of CMV.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The new generation of young people does not adhere to the MD pattern although they live in the lands characterized by the tradition and culture of healthy diet and where the benefits from this pattern were initially discovered.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Breast cancer survivors experience substantial unmet needs years after end of treatment, particularly among younger women and women having clinical FCR.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The outcome of the trial suggests that the recommendations of the Guidelines for controlled Trials of Drugs in Cluster Headache from the IHS should be revised.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "St John's wort can be used as an effective treatment for the vasomotor symptoms of perimenopausal or postmenopausal women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Six months after RYGB, systemic inflammation was reduced in both supplementation schemes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Studies with larger numbers of patients are needed to assess  the efficacy of this intervention.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: cris.nih.go.kr: ( KCT0001225 ).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research is needed that examines the formation of BRCA1/2 mutation noncarriers beliefs regarding their disease and available treatment options, and that characterizes the physician-patient communication that occurs in this complex decision-making context.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, these findings reveal that the benefits of  physical activity to improvements in cognitive function are particularly evident among children who are obese.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study provides a detailed overview of the used techniques of oncoplastic BCS and their postoperative complications.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gemfibrozil improved the uraemic dyslipidaemia and hypercoagulable state by reduction in activation of blood coagulation, indirectly suggesting a reduction in lipid-dependent extrinsic pathway activity which should contribute to reduced risk of thrombosis and CVD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Pilates method could be used as an alternative to improve mood disorders in overweight/obese individuals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The lateral decubitus in knee-chest position with a 45-degree head-up tilt may be the preferred position for spinal anesthesia in young and elderly patients, due to the high success rate.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As SFx is linearly related to plasma propofol concentration, this index may be used to measure anaesthetic effect during propofol anaesthesia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additional studies on the optimal 25(OH)D concentrations in early life  are needed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Excessive secretions are rarely a factor in elective and premedicated intubations, and routine suctioning should be discouraged.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study highlights the need for improvement in other aspects of care to improve LOS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The large discrepancy between the self-reported and objective measures of MVPA meeting the 150-min criterion suggests that self-reported physical activity measures should be used with caution in intervention studies.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings highlight the need for the development of effective violence interventions addressing violence in nonpartner relationship types.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Theory-based behavioral interventions tailored to adolescent girls can help to reduce sexual risk and may also reduce unintended pregnancies.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Large area obesity trends mask substantial and increasing region-level disparities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "this study confirms that the presence of dysphagia during the acute phase of stroke is associated with poor outcome during the subsequent year, particularly at 3 months, and is associated with increased institutionalisation rate in the long term.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, these biomarkers are predictors of T2DM subjects and should take more attention to measure levels of these as well as to target therapy/interventions.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Out-of-hours services adjacent to A&E departments do not offer wider access to diagnostic tests.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Knowledge of the healthcare system is necessary for optimal healthcare-seeking behaviour.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consequently, this measure may not reliably capture and explain how painful and provocative events relate to fearlessness about death, which is a barrier to improving suicide risk assessment and prediction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Regions with similar challenges in context and  high risk populations for diabetes in pregnancy may benefit from this experience  of implementing a register.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rs1122608-G allele was a significant risk factor of CAD in the Asian male population but not in the Asian female population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This prospective study showed that the evolution of vascular TOD is different in participants with type 2 diabetes compared with those with MetS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Retired adults were more likely to be physically active but were not more likely to be adhering to most of the Lifes Simple 7 lifestyle and cardiovascular risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Clinicaltrials.gov NCT00895141.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is no advantage in routinely sending midstream urine samples for testing, and antibiotics targeted with dipstick tests with a delayed prescription as backup, or empirical delayed prescription, can help to reduce antibiotic use.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The advent of genetic diagnosis will redefine the syndrome with likely effects on the prognosis of the defined group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study replicates previous findings suggesting a need for additional retention strategies for younger women with dependents in comorbid PTSD and alcohol use disorder treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results may aid current strategies for preventing and controlling pediatric hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patients tolerate the PTCA procedure very well under the assistance of intra-aortic balloon counterpulsation (IABP) even in very severe condition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Psychiatrists should learn to properly treat diabetes, hyperlipidemia and hypertension when detected.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has implications for tackling pathological (over)eating.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effects of TRT on cardiovascular risk markers were ambiguous.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study identifies certain populations who may have increased responsiveness to treatment with antimuscarinic therapy and may be used to inform and guide future therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings, if confirmed in the general population, could have important implications for the prevention of hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Removable overdentures can be used on both one-piece titanium and zirconia implants with these attachment systems, due to no difference in prosthodontic maintenance and success.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contracts did not increase follow-up adherence to eye appointments in diabetic patients with ocular abnormalities.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Green tea mouth rinse can be a promising preventive therapy worldwide for the prevention of dental caries.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Performing the task whilst lifting or lowering a submaximal load showed a reduced trunk repositioning error in subjects with subacute low back pain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of our interventional study suggests that zinc may be used to treat primary dysmenorrhoea in adolescents.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Registered with Current Controlled Trials (Registration: ISRCTN55141306 ).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The MBDA score did not reflect clinical disease activity in patients enrolled in AMPLE and should not be used to guide decision-making in the management of RA, particularly for patients who receive abatacept or adalimumab as the first biologic agent.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It took 30\\xc2\\xa0months for system usability and staff engagement scores to rise, after falling significantly for the first two\\xc2\\xa0years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has implications for the design of therapeutic trials and the clinical application of the device.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Researchers should consider the trade off between the value of additional questions and a larger sample.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, our findings may not be generalizable to susceptible and immunocompromised persons because these groups were specifically excluded from the study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Kefir drink causes a significant yet similar improvement in serum lipid profile, compared with low-fat milk, in a dairy-rich diet in overweight or  obese premenopausal women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduced fibrinogen and increased albumin are consistent with a reduction in the acute phase response.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Laparoscopic surgery can be conducted safely in selected patients with penetrating CD without increasing the risk of postoperative complications.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dulaglutide was well tolerated and had a low risk of hypoglycemia when used without insulin secretagogues or insulin.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most frequently affected is depersonalization, followed by emotional exhaustion and finally the personal accomplishment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serial assessment of hsTnI revealed a substantial proportion of patients with type 2 diabetes mellitus without clinically recognized events had dynamic or persistently elevated values and were at high risk of recurrent events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, in the absence of any adverse effects, LGI diets remain an option for diabetes and cardiovascular disease risk management.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients treated with SSN blocks had less pain overall, which led to a decreased need for analgesics in comparison to the subacromial infiltration and placebo groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, industry-sponsored messages in which companies have an economic incentive to increase consumption behaviours should be treated with scepticism and evaluated independently.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mentoring can be an effective way to benefit mood and healthy coping after TBI, and it can help to prevent maladaptive behaviors, such as substance abuse and behavioral dyscontrol, in the living situation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The volume of the gastric remnant increased significantly during the first year after LSG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings need to be confirmed  by independent large studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study proposes a clear line for  research directed at specific risk factors that refer to an individuals clinical, allergic, health, and socioeconomic status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From a practical perspective, the study provides insightful results for healthcare professionals.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of a water-based HS did not have an additive effect.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This therapeutic combination may be indicated for the prevention of colds and its most common symptoms in the general population when administered as a preventative supplement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The rate of incidental findings prompting a change in management was low.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are important to support the formulation and implementation of NCD-related polices and plan of actions that recognize urban slum populations in  Bangladesh as a priority sub-population.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In women with early BC, AI therapy is associated with high prevalence of radiological VFs, which were shown to be independent of BMD values  during the adjuvant treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, pharmacovigilance should be maintained where SMC is implemented and provision for strengthening national pharmacovigilance systems should be included in plans for SMC implementation.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RHR is positively associated with baPWV in healthy Chinese population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, the monitoring of anti-malarial drug efficacy should continue.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An immune reconstitution syndrome should be considered in patients with Whipple disease in whom inflammatory symptoms recur after effective treatment.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When compared with conventional HWL, ROLLIS is associated with significantly less stress and discomfort for patients prior to breast conserving  surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A low threshold for performing preoperative imaging in patients with AMD, especially in those with exudative AMD in the fellow eye, to exclude undetected CNV is recommended.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, provision of information may reduce subsequent depression and anxiety, while reducing depression and anxiety levels may increase satisfaction with received information.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mortality rate of chronic systolic HF patients carrying no \\xce\\xb1(2c)-adrenoceptor Del322-325 alleles was significantly higher (almost 2.5-fold) than that of HF patients carrying \\xe2\\x89\\xa51 allele.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GDM significantly diminished the likelihood of a trial of vaginal delivery after cesarean delivery and its subsequent success.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Few events during this long-term follow-up preclude identifying specific features of patients at risk of relapse and illustrate the need for a large data-base.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AMP is not necessary to prevent SSI after clean thyroid or parathyroid surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both COC use and higher BMI increase risk for VTE, and the greatest relative risks are for those with both risk factors based on a body of evidence graded as Level II-2, fair to poor  quality.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies should be directed to these patients to improve outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Targeting the factors related to unmet social support may be a helpful way to promote healthy behaviors among overweight postpartum women.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Type of treatment had little impact on mortality, morbidity or functional outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The influence of meat and bread consumption on OIDP varied significantly according to T2D status.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The serum YKL-40 level is associated with endothelial dysfunction and increased arterial stiffness in NS patients and may be an indicator of the level of proteinuria in this patient population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "SPA can be considered a prognostic factor in postoperative morbimortality for patients with cancer.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Build-up of AL was found in adolescent boys and was positively associated with life event stress.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The autogenous DDM granules prepared at the chairside after extractions could act as an excellent readily available alternative to bone graft material in GBR, even for implantation of severe periodontitis cases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings offer preliminary support for the usefulness of CFT-based interventions for BED sufferers.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reduced compliance with preoperative nutritional interventions remains a major issue because the expected benefit depends on the actual intake.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both symptoms and QoL improved significantly in patients with PersAF after ablation.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Before the FRI can be recommended for widespread use in patients with neck and low back pain, it should be further tested in patients with neck pain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pericardial fat was significantly associated with myocardial ischemia in patients without known CAD and may help improve risk assessment.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the mechanism(s) of decreased insulin resistance by flaxseed should be further determined using flaxseed lignan.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A new comprehensive stress radiographic technique for diagnosis of chronic lateral ankle instability presented in this study might be a reliable and representable measurement tool to assess additional injury or instability of the subtalar joint.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It could be used for evaluating screener performance and create internal quality improvement.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of the ultrasonographic survey of the living population and of hospital autopsy data were comparable, with slightly higher gallstone detection rates in the autopsy study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Partial cystectomy is an alternative to total cystectomy for bladder RMS when the tumor site makes it anatomically feasible.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Downregulation of STAT4 in HCC indicated aggressive tumor behavior and predicted a worse clinical outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The strong and independent association of CMI with ischemic stroke in females, in comparison with the much lesser degree in males, provides further insight to better stratify by sex in investigations of ischemic stroke and solidly corroborates the potential role of ischemic stroke prevention targeted at CMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, this result should be interpreted with caution, since it included a relatively small number of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is necessary to have standardised dynamic tables for each surgical technique, becoming essential elements to measure weight loss after surgery.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The perception of relief, as confirmed by objective lung function assessment, provides evidence that budesonide/formoterol can be used as reliever medication in asthma.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Attention to the onset times of side effects and cross-reactivity of ATDs can lead to safer treatment of GD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Clinical trials should be performed to assess the performance of these products before definitive conclusions can be formulated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings support the use of the 400-meter walk to evaluate progress in physical activity or weight loss programs.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings indicate that ziprasidone may be effective in achieving sustained remission in bipolar I disorder and propose that a better understanding regarding the definition of remission in bipolar disorders should be required in clinical practice since our results showed different remission rates with different remission criteria.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether supplementation of individuals with low vitamin D will result in similar benefits will require a randomized clinical trial.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "(Funded by Lexicon Pharmaceuticals; inTandem3 ClinicalTrials.gov number, NCT02531035 .)", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The optimal BIS value during intravenous sedation in sedated ambulatory patients in dental surgery should be within the 80 to 85 range.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A minority modified their diving practices to mitigate the risk of their condition and approximately half sought specialist diving medical advice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limited evidence of Level II-2, fair quality, concerning whether CHC  use modifies the risk of AMI and stroke in obese women is inconclusive, while a single study of Level II-2, poor quality, found that obese COC users may be at higher risk for CVT compared with normal-weight nonusers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Observational pain assessment underestimates children's perception of pain and should not be recommended in children aged >3 years.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "QA showed high protocol compliance and adequate dose coverage in most patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The FINDRISC questionnaire is a useful instrument for identification of individuals with impaired glucose metabolism but seems less effective for detection of individuals with impaired glucose tolerance.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important for researchers and practitioners to focus on increasing behavioral strategies for physical activity adoption.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Application of either form of therapy  alone may only have relatively miniscule effects on the aforementioned factors, in relation to the aggregate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is important to make efforts to watch the growth of the children during their first 3 years of age, to focus on improving the diet of women at fertile age and pay special attention to  environmental conditions to break the vicious cycle of malnutrition.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Also individually green tea consumption and abdominal obesity have failed to find an independent relationship with lacunar infarction after adjustment by all risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "PLD has efficacy comparable to that of common salvage regimens in patients with taxane-refractory metastatic breast cancer, thereby representing a useful therapeutic option.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Having better nutritional status is associated with improved adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future work is needed to examine the impact of improved glycemic  control on clinical outcomes following LER.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Screening for possible death is not the best option for initiating end-of-life planning: recognising increased burden of illness might be a better trigger.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Shrimp is a common allergic food in southern China.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Clinical Trial Registration: NCT01931111 (Date of trial registration: July 19, 2013).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Improvements in ICB may be necessary for it to be used as an alternative method to PVB.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Previous preterm delivery, abortion and prematurity and fetal loss/abortion and prematurity all increase risk for subsequent preterm birth with or without PROM.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transperiodontal probing appears to be suitable for the measurement of biological distances and may be used as an important tool for surgical planning.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Internet use for general parenting issues in Sweden, mainly by women, does not seem to follow the digital divide phenomenon.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, it is important to develop and use profile-screening tools to identify these children.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Limited sample sizes may have contributed to insignificant findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, BMI and alcohol do not demonstrate significant interaction in this group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings highlight the feasibility of tailored breastfeeding support for the substance-exposed mother and baby and endorse the promotion and support of breastfeeding for this group.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IMPLICATIONS FOR CANCER SURVIVORS: This promising pilot trial suggests a need for more research on preventive counseling to maintain sexual function during aromatase inhibitor treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Weight loss of 5% to 10% has an efficacy similar to that of other  nonsurgical treatments and should be considered a first line therapy for incontinence.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Other institutions with CPOE should consider adopting similar order sets as part of a comprehensive inpatient glycemic management program.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The determination of the action spectrum for PUVA-induced erythema is important as it permits reliable estimates of erythemal efficacy of any UVA source where the emission spectrum of the lamp is known or can be measured.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There are significant age differences in adherence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Besides, VLDL,  LDL-C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Acceptance of the validity of such data may create the erroneous impression that  undernourishment is desirable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fibrinolysis may pose less risk of acute clinical deterioration and should be the first-line therapy for children with empyema.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A positive association between severe eating disorder psychopathology and clinical depression was observed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This form of monitoring should be taken into consideration in the future for systematic use in prolonged sedation, as in the case of EBUS.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high prevalence of deviations in body constitutions was observed in the follow-up stage of breast cancer patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NAFLD occurred in 8.2% of the IBD population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surprisingly, UW patients are associated with higher mortality as well as respiratory events postoperatively.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The high proportion of variation explained by hospital factors suggests potential opportunities for improvement, and identifying specific complication categories may provide focus areas.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mild-to-moderate kidney dysfunction is associated with a significantly elevated risk of VF in the setting of acute STEMI.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, no statistical difference was detected in the rate of malignancy between non-mass enhancement with (18%) or without (12%) a correlate.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative treatment with carvedilol prevented paroxysmal atrial fibrillation after CABG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings require further investigation in prospective studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This small pilot RCT provides exciting proof-of-concept data supporting progressive treadmill walking exercise training for potentially improving learning and memory and underlying hippocampal viscoelastic properties in persons with MS. This is important given the high prevalence and burden of MS-related memory impairment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although artificially sweetened beverages and fruit juice also showed positive associations with incidence of type 2 diabetes, the findings were likely to involve bias.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Different prognostic factor combinations distinguish high-risk populations of early or late HCC recurrence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, it is planned that they will guide establishment of a national policy for the diagnosis and treatment of FH in Turkey.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: www.clinicaltrials.gov identifier: NCT01404195, registered 22 July 2011, HYPERPROT-GER Study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of FG as an interpositioning layer during the vaginal anatomical repair of complicated VVF appears to be of great value as an alternative to the use of MF interpositioning.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The need for bail-out therapy was associated with a less favourable outcome.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high completion rate was achieved, compared with published results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The advantages and disadvantages of adding pioglitazone instead of adding basal insulin should be assessed further.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: CRiS KCT0002267.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: Not applicable.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indoor air pollution and delayed measles vaccination increase the risk for severe pneumonia among children aged below five years.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both FDADM and SDADM can be used successfully to correct Miller Class I or II recession defects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further consideration should be given to modifying perioperative care and postoperative evaluation of patients with a history of AWR.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, functional distraction using JESS can be utilized as an alternative method in cases of neglected and resistant clubfoot.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Correct and meticulous placement of the flap inside the cystic cavity is the most critical issue for the success of the procedure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It avoided lymphadenectomy in more than 70% of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggested that oral administration of BCACs may induce a beneficial decrease in IOP levels in healthy subjects as well as in patients with glaucoma.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION IDENTIFIER: NCT01816594.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The concurrent iron deficiency correlated with the presence of goiter.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The staff-supported approach holds promise for encouraging exercise among wheelchair users, yet additional support may be necessary to achieve more exercise to meet national recommendations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LSG after abdominoplasty is associated with longer operative times and the need for additional port placement to overcome the decreased working space.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is suggested that DHA down-regulates the expression of the LDL receptor.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor glycemic control among diabetics is a risk factor for TB occurrence.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strategy offers a promising alternative to the high rates of attrition and relapse currently observed with agonist tapers in both inpatient and outpatient settings.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This finding could open new avenues for the development of novel adjuvant strategies, including bone-targeting agents.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only 48% of the patients admitted with ACS had normo-glycaemia based on OGTT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Biweekly submucosal injection of hyaluronidase over a period of 5 weeks appears to be a viable treatment option for OSF.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients who had had a recent acute coronary syndrome, dalcetrapib increased HDL cholesterol levels but did not reduce the risk of recurrent cardiovascular events.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Application of antibiotic protocols drawn-up by the clinicians, microbiologists and chemists concerned appears to be an efficient solution that is clearly acceptable to the various participants.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies in large samples and not based on self-reported behaviors should be developed.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Medication and swallowing difficulties were not associated with change in BW.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The degree of obesity does not linearly predict OSA severity in children.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: ClinicalTrials.gov, number NCT02942602 .", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future trials should work closely with study partners to ensure referral of a representative study sample.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggest that ologen may be a useful alternative to MMC in JOAG.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on these results, BAY 86-5047 is unlikely to be useful in the treatment of women with endometriosis-associated pelvic pain.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An early increase in repeat  visits indicates a need for the establishment of evidence-based guidelines and caution with systematic prescribing of MMN.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results of this  study provide empirical support for the safety and feasibility of HBHC when a child is diagnosed with type 1 diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data suggest a possible link between periodontitis and glycemic control in nondiabetic individuals, periodontal disease may be a potential contributor to the development of type 2 diabetes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "lower extremity muscles endurance exercise followed by a cardiorespiratory endurance exercise can be used to increase physical fitness in ID patients with obesity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A key finding was that participants were motivated to persist with ICBT when their overall need for relatedness was satisfied.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should address ways to modify the program to improve achievement of CSWL.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Levobupivacaine with opioid co-administration can be used in doses considerably lower than doses proposed for routine use as it is a safe drug depending on its hemodynamic effects, side effects.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The treatment-associated increase in DNA methylation is correlated with a concomitant reduction in OS markers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DM defined by HbA1c \u221a\u00a2\u201a\u00c4\u221e\u00ac\u2022 6.5% is an important determinant of mortality  following surgical treatment for AAA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among participants with diabetes, low-chlorine PCBs increase the risk of ESRD and death without ESRD, whereas several PSTs predict death without ESRD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The risk of developing either MS or NAFLD was significantly associated with serum Hb levels in men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addition of the pan-PI3K inhibitor buparlisib to taxane-trastuzumab-based therapy in HER2+ early breast cancer was not feasible.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Advocating the initial use of bulb syringes could reduce demand for ear irrigation in family practice clinics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study indicates that antibiotic prophylaxis is effective for the prevention of SSI after open mesh-plug hernia repair.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "School physical activity environment should be considered in future epidemiologic and intervention studies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that MPV could be used as an acute phase reactant in children with rotavirus gastroenteritis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the low agreement between the methods, the combination of both may be beneficial for the nutritional assessment of pediatric patients, collaborating with the early diagnosis of nutritional alterations and facilitating the use of adequate dietary therapy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deaf women are not at increased risk of the majority of adverse pregnancy and neonatal outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metformin may protect against coronary atherosclerosis in prediabetes and early diabetes mellitus among men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fetuin A showed a remarkable interaction with nutritional status in  evaluating the risks of CV morbidities in prevalent HD patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings illustrate the importance of considering loneliness for physical and mental health and lifestyle factors, not only in older and younger, but also in middle-aged adults.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health care providers should be aware of MU as a contributing factor in the approach and treatment of HF in NHs and PIPs.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We suggest that in pharmacogenetic research, extreme non-responders should be excluded to overcome the problem that non-adherence is investigated instead of non-responsiveness.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present findings show a 5% upgrade rate to DCIS.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This non-pharmacological strategy can be suggested because of its effect on reducing changes in heart rate during painful procedure.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the occurrence of a performance-bias due to the increased level of attention from physicians to patients in Pa-O group, cannot be ruled-out.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may have important implications for understanding how CRF contributes to the progression of CHF and increases morbidity and mortality in CHF patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A combination of honey and coffee can be used as an alternative medicine in the treatment of PPC.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found excellent results with arthroscopic resection of the acromioclavicular joint and concomitant subacromial decompression.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results demonstrate that CKD patients have a lower degree of DNA  methylation and that cholesterol lowering treatment restores mCyt DNA concentrations to levels similar to healthy controls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IGT after pediatric liver transplant is driven by inadequate insulin  secretion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further prospective research with longer follow-up periods is needed to confirm or contrast the present results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Changing from conformal to IMRT, or from PTV(10-7) to PTV(3), did not produce a uniform interpatient increase in TR(mod)when the CTV contained the prostate alone.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Estradiol appears to be a useful treatment for women with schizophrenia and may provide a new adjunctive therapeutic option for severe mental illness.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unlike active chronic smoking, acute passive cigarette smoke exposure modestly decreases EXU bioavailability and thus should not increase hypoglycaemia risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Restriction of dairy and meat consumption is common and is negatively associated  with intake or status of micronutrients like calcium and iron.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 12-week yoga intervention was associated with greater improvements in mood and anxiety than a metabolically matched walking exercise.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Decreasing the operative time and adding simplicity to the already complicated procedure are additional values of using this procedure.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results imply that school based nutrition education should be a part of comprehensive school health programs to reach students and potentially their families.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The significant increase in fibrinogen in all renal disease states was associated with evidence of an acute phase response, protein losing states and hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The preoperative nutritional status affected the postoperative survival time in patients with esophageal cancer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that factors that are amenable to intervention concerning breast cancer awareness and health care access, rather than intrinsic  tumour characteristics, are the strongest determinants of stage at diagnosis in Nigerian women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This has implications for surgical education as it may inform the selection of the most suitable laparoscopic simulators for specific populations of trainees.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intermittent perirenal instillation of bupivacaine via the nephrostomy tract after PCNL decreases the need for more systemic narcotics and provides acceptable analgesia in the postoperative period.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this large-scale, real-life setting, patients with HER2-negative  MBC who received paclitaxel plus bevacizumab as first-line chemotherapy had a significantly better OS and PFS than those receiving paclitaxel.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore it should be used with caution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results have implications for our understanding of the cognitive mechanisms of benzodiazepine treatment.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As long as the current management of low-risk DCIS remains surgical excision, the present results support continued excision of MLLs, either surgically or by vacuum-assisted biopsy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This prospective study suggested that there was an inverted-U-shaped relation between neonatal vitamin D status and neurocognitive development in toddlers.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elevated BMI was associated with a lower risk of PCa, regardless of grade.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The combination treatment regimen of ME-CyA and PSL with C2 >600\\xc2\\xa0ng/ml has potential to be an important treatment option for adult new-onset MCNS patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The indication of an associated extra-articular plasty remains very discussed but we plead for an objective criterion with knowing the importance of preoperative objective laxity especially that of the lateral compartment to decide if it necessary, or not, being associated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study provides a link between iron nutrition, physiological deregulation and stress.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "AHI contributed to higher AIP level.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It suggests a genetic pre-disposition involving the dopaminergic signalling pathways known to play a role in food reward and satiety linked mechanisms.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies with larger numbers of patients, limited to HCC and liver resections, are needed to verify our results.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "LIMITATIONS: The heterogeneity of the study group (different diseases at different stages) could influence the generalizability of our findings.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Undiagnosed CD can confer benefits and liabilities to older individuals.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Obstruction at certain anatomical levels contributes more towards obstructive sleep apnoea severity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During infraclavicular subclavian venous catheterization, interruption of mechanical ventilation does not seem to be necessary for the prevention of pneumothorax.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During the period of SARS epidemic, some of the traders did infect with SARS-CoV, but they were neglected due to clinically inapparent manifestations.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transfers destined for food consumption combined with nutrition training reduced IPV among marginalised households in northern Ecuador.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, physicians should not disregard MS when a patient presents with any of these rare manifestations.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "IG was more effective then DP in the treatment of GERD in patients with diabetes, and may be recommended for inclusion in the scheme of treatment of this comorbidity.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The look-back process, even in a single centre with a stable urban population, is relatively inefficient in screening at-risk populations.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A high prevalence of IR amongst young tuberculosis patients therefore highlights the need for early identification in order to facilitate a reversal of IR and prevent possible IR-related complications.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings warrant replication from a long-term, adequately powered, RCT.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to examine the impact of reproductive factors on early-onset BC in African women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GDM appears to influence fetoplacental apelin metabolism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study demonstrates that the elevated TG/HDL-C ratio predicts poor CVD outcome in subjects with CKD.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is significantly superior for 3D-EAUS to detect the internal opening, fistula classification and identification of a second track in complex anal fistulas as compared to conventional examination.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results can be used for simulation in further clinical trial and optimize individual dosage regimens using a Bayesian methodology in patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Stressing the use of modified criteria more universally to classify obesity among South Asian Indians may be optimal to identify obesity  and help appropriately risk stratify for intervention to prevent chronic diseases.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A higher BMI and a greater prevalence of comorbidities had driven patients to seek a more radical solution for their obesity, i.e., surgery.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Heavy RME forces affected premolars and molar similarly.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Associations were evident in both sexes and consistently more pronounced among women than men.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the similar rates of successful stone removal and complications, EST plus LBD should be an effective alternative to EST.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Small changes like giving additional UI-specific information and devoting more attention to UI (which had been given little attention before) would provide a simple instrument to stimulate patients to change their behaviour in the right direction.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among patients with HER2-negative metastatic breast cancer and a germline BRCA mutation, olaparib monotherapy provided a significant benefit over  standard therapy; median progression-free survival was 2.8 months longer and the risk of disease progression or death was 42% lower with olaparib monotherapy than with standard therapy.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Each age subgroup presents varied demographic and behavioral factors that put them at varying levels of risk for birth defects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "C+T raise is an early predictor for everolimus efficacy for patients  with mRCC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, this readily available box trainer may be used as an effective, flexible training device outside the operating room to improve accessibility to simulation training.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further studies are needed to fully characterize the accuracy of these tests when applied in a routine pulmonary medicine practice setting.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As the implementation of EN is simple and has good compliance, family EN is proven to be feasible.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If commercially available, a combination of topical nesterone and testosterone gels could provide a reversible, effective method of contraception that is appealing to men.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We suggest that the role of IL-6 genotype should also be studied in relation to other associations between gastrointestinal microbiome  and cardiovascular risk factors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further randomized clinical trials should be performed in order to obtain strong conclusions.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The improved sensory nerve function observed after 12 weeks of therapy was maintained at 60 weeks, and improved motor nerve function was observed at 60 weeks.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The small increases of TSH, TT3 and TT4 level may be related with these metabolic changes in PCOS patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oral ketamine may be used to reduce postoperative pain following orthopedic procedures in the traumatic patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since female sex is a component of most risk scores, the findings may identify a potential inaccuracy in current surgical risk assessment, specifically for elderly women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study indicated that adherence to the WCRF/AICR recommendations is inversely related to CRC risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The current findings demonstrate that sildenafil can induce browning of sWAT in human, and this action may be through cGMP-dependent protein kinase I  and mechanistic/mammalian target of rapamycin (mTOR) signaling pathways.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Metformin treatment is associated with a significant reduction in OM irrespective of diabetes status in patients with EC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with NASH undergoing RYGB are more susceptible to early transient deterioration of liver function than after SG.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The speed of the 15.2-m walk as a measure of walking ability compared to the distance walked in 6 minutes may not represent separable domains of mobility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It seems to be important for long-term health to take into account: 1.)", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that greater levels of social support may improve certain indicators of physical and mental wellbeing in older adults with  type 2 diabetes, regardless of the presence of diabetes complications and other chronic pathologies.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since the current evidence consists of a few studies (mostly observational) of low methodological quality, there is an urgent need to initiate rigorous prospective studies (preferably randomised controlled trials).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is recommended for athletes and young active individuals, and can be used as an alternative to conservative treatment or plate fixation.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Taking people's overall evaluation of their health into account when assessing total health risk is important.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Due to the potential for hypotension, the concomitant use of nitrates and tadalafil is contraindicated.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, the use of formulas containing a mixture of carotenoids should be recommended for long-term enteral nutrition.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This pilot study indicates that the intervention is feasible and acceptable by patients at risk of pressure ulcer.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Trainer selection for competence may be particularly critical for group-based TTT programs involving experienced counselors and the use of experiential activities.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results suggest that pulmonary endarterectomy can be safely performed with moderate hypothermia and short periods of circulatory arrests without the need of profound hypothermia.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TRIAL REGISTRATION: The trial was registered at ClinicalTrials.gov (registration  number NCT02073188).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "L-trp is a luminal regulator of CCK release with effects on gastric  emptying, an effect that could be mediated by CCK.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the methodology used was adequate for integrating clinical and economic information at the PCC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interventions should be based on theory including HBM and CSM constructs, and should target first BS uptake and specific barriers to reduce disparities and increase BS uptake in Malta.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The hypothesis of a catecholamine-induced myocardial \"stunning\" is emphasized by the evidence of a reduced 123I-mIBG myocardial activity, impairment of myocardial glucose metabolism, and wall motion kinetic after the same temporospatial distribution.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study identified predictor factors positively associated with ideal weight loss.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The findings from this prospective study support the use of nutritional assessment in inpatients to predict PU risk and target appropriate interventions.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data indicate that traction radiographs may provide some of the same information as computed tomographic scans at a lower cost and argue for additional research comparing computed tomographic scans and traction radiographs of the distal part of the radius.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These patients have experienced a focal, microvascular central nervous system ischemic event at a relatively young  age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although an increase in peripapillary RNFL thickness was observed one month after 577-nm PASCAL photocoagulation, there were no significant changes at  the one-year follow-up compared to the baseline.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participatory community-based nutrition education for caregivers improved child dietary diversity even in a food insecure area.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For every 4 kg/m(2) increase in BMI, observational estimates suggested a 26% increase in odds for IHD while causal estimates suggested a 52% increase.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Some non-communicable diseases were already more prevalent in women with morbid obesity even before 50 years of age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "%TWL places the 3\\xa0cm group in higher percentile than 8\\xa0cm group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "So, it can be used in dengue fever with thrombocytopenia patients.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These over-the-counter-specific kinematic changes should be taken into consideration when recommending these devices as a treatment option.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients had a dramatic improvement in BMI after bariatric surgery and those with prior bariatric surgery had a lower risk of re-operation and revision in the short- and mid-term after a subsequent THA.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies should use multiple Black and White communicators to isolate the role of race and should be conducted where larger samples of African American college students can be recruited.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subcutaneous PP 1420 was well tolerated in healthy human subjects at single doses between 2-8 mg, with no tolerability issues arising.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A very brief self-regulatory nutrition intervention was superior to  a control condition.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Groups of patients particularly liable to develop colorectal neoplasia or particularly resistant to it can be identified.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Education initiatives, regulatory maneuvers, and process improvement should be targeted at sites where anesthesiologists do not comply with current guidelines.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One out of 7 patients was scored as undernourished.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings are potentially useful for screening purposes and for optimizing prevention strategies targeted at reducing the incidence of postoperative delirium.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Public health recommendations advising the use of smaller dishware to reduce food consumption are premature, as this strategy may not be effective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "NT in control individuals without gallstones was significantly prolonged compared with the NT in patients with established gallstone disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Head Start programs reported using a multilevel approach to childhood obesity prevention that included staff, parents, and community partners.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present trial indicates that pregnant women should exercise, and in particular do PFMT, to prevent and treat urinary incontinence in late pregnancy.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MTHFR A1298C polymorphism might contribute to an increased risk of breast cancer and/or ovarian cancer susceptibility.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BBAVF has the advantage of a higher patency rate, a lower complication rates of infection and thrombosis, should be served as a favourable choice in building the vascular access in maintenance hemodialysis patients.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It may obviate the need for more complex procedures; at the same time, it also addresses the potential drawbacks of a simple closing wedge osteotomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unique identifiers: NCT01507831, NCT01623115, NCT01709500, NCT01617655, NCT01644175, NCT01644188, NCT01644474, NCT01730040, NCT01730053, and NCT01709513.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was some evidence of a less steep socio-economic gradient in overweight in eight-year-old girls over time.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study confirms the well-known negative metabolic changes in PCOS patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Intraoperative radiographs may be valuable in setting of clinical suspicion.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although current consensus guidelines recommend consideration of CT in all TNBC larger than 5\\xa0mm, clinicians should carefully discuss benefit/risk ratio with patients, given the unproven benefits.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For a partial case-control study, log-linear model could estimate not only the main effect of environment but also gene-environment interaction.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We concluded that the effect of TAH or TAH+BSO operations were mainly on sexual desire and the number of weekly intercourse, and estrogen in the postoperative period did not make any difference between the two groups.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High-risk populations may accept CESM as a screening exam and may prefer it over screening MRI if ongoing trials demonstrate screening CESM to be clinically non-inferior MRI.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study reveals a 4.6% annual increase in ED demand in WA in 2007-2013, mostly because of an increase in people with urgent and complex care needs, and not a shift (demand transfer) from primary care.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "palpation and Johnson's technique can be used as alternatives to ultrasound for EFW, particularly if the measurements are taken by experienced, skilled personnel.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "More than three-fourths of the patients in this study had a history of smoking, which is considered a triggering or aggravating factor for PPP.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is critically important to develop cost-effective strategies to reduce the TB burden.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "a high intake of fats, phosphorus, vitamin B5, vitamin E, and selenium intake and red meat appears to be related to the presence OSCC in Cordoba, Argentina.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results should be confirmed in a larger trial and whether this advantage translates into an improvement in clinical outcome should be tested in a trial with primary clinical endpoints.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Success rates may be modest, but most adverse effects are mild and/or transient; however, significant loss of IOP control can occasionally occur.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CLINICALTRIALS.GOV IDENTIFIER: NCT02244879.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings seem suggest that improving muscular fitness as well as an adherence to the SEADiet could be an important strategy to reduce clustered cardiometabolic risk in youth.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This suggests the need to compare acetate kinetics in normal and hyperinsulinaemic subjects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Infusion sets containing di(2-ethylhexyl) phthalate should not be used with warming devices in order to avoid toxic effects.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, intensive prenatal nutrition counseling offered in an urban community health setting may decrease LGA births among a group of overweight and obese women from culturally diverse backgrounds at risk for adverse maternal and neonatal outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgeons should consider the predictors identified in our analysis to inform patients treated for tibial shaft fractures.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The participants had a high attendance rate in the program, which speaks to the likelihood of the applicability of the meditation program on an outpatient basis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To confirm these findings, further prospective studies with larger sample size and longer follow-up are warranted.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Potentially pathogenic bacteria are detectable on ambulance staff uniforms when a shift ends.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A higher weight gain contributed in a negative manner to the presence of dyslipidemias in these patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypertension prevalence increased with age and was more prevalent among men than women.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuous monitoring of artemisinin effectiveness for malaria treatment should be established in high malaria transmission areas in sub-Saharan Africa where spread of resistance would be disastrous.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings suggest that tension and post-surgical factors play a causal role in this hitherto undescribed entity: post-reconstruction dermatitis  of the breast.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on the findings of our study as well as other studies, we believe the minimally invasive percutaneous adhesiolysis procedure should be the first choice treatment option for patients with chronic lumbosacral radicular pain who present with clinical history and findings similar to those of the patients enrolled in our study.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The data were analyzed using IBM SPSS software version 22.0 (IBM Corporation, New York, USA); this cross-sectional study was conducted between April 2015 and May 2016.\\xa0", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We attempted to replicate these associations by similar analysis of two familial-obesity case-control cohorts and a population cohort, and detected GSVs at 11 out of 18 loci, at frequencies similar to those previously reported. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Follow-up data were obtained for 33 participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The stress level was found to be significantly associated with the risk of atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results - We found no statistically significant difference in the improvements in HOOS-PS between the treatment groups at 12-month follow-up. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "On Kaplan-Meier survival analysis, women with both an elevated level of CRP and a high NLR had a shorter admission-to-delivery interval compared to women with either an elevated level of CRP or a high NLR alone. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further study is needed to verify this conclusion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Negative sputum culture conversion was achieved and maintained in all except two mortalities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These two gene pairs were validated in three independent data sets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The physicochemical modification of allergen vaccines provides a chance for administering higher doses in a shorter period of time. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "E2 also suppressed ACTH ApEn (process randomness) during continuous cortisol feedback (P = 0.004). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This cross-sectional study was conducted among conveniently sampled patients attending dental clinics, located in Kuala Lumpur, Malaysia to assess association between self-medication with analgesics and patient's beliefs about medicines via Beliefs about Medicines Questionnaire.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The tolerance was assessed by recording all side effects related with immunotherapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies are needed to determine if this intervention reduces falls risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MATERIAL AND METHODS Medical records of 170 patients who underwent hysterectomy following cervical conization between November 2010 and September 2016 at the Zhenjiang 4th Hospital were reviewed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Communal living participants who resided in the house for over 6 months showed the most substantial increases in tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Allergenic potency determined by enzyme allergosorbent test (EAST) inhibition and skin prick test showed that modified P. judaica pollen had a 99.9% less allergenicity than native extract. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The estimated NRS pain score on the day of surgery was 5.08 (95% confidence interval [CI] 4.97-5.19) in group N patients and 6.73 (95% CI 6.65-6.80) in group R patients (P\\u200a<\\u200a0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We assessed the feasibility of hand-held photoscreeners to screen for vision disorders in pre-school children in Hawai'i.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therapies included opioids, nonsteroidal antiinflammatory drugs, acetaminophen-opioid combinations, postoperative continuous epidural infusion, anticonvulsants and tricyclic antidepressants for neuropathic pain, local anesthetic wound catheters, and continuous peripheral nerve block catheters. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Median time from onset of any symptoms to arrival at hospital was 22 hours longer for MPI poor adults compared to non-poor adults (123 vs. 101 hours) rising to a difference of 26 hours with adjustment in a multivariate regression model (95% confidence interval 7 to 46 hours; P = 0.009). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found evidence of ST410 being a highly resistant globally distributed lineage, capable of patient-to-patient transmission causing hospital outbreaks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The main outcome measures were mean ACTH concentrations, pulsatile ACTH secretion, and ACTH approximate entropy (ApEn). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ROC curve of logARR and plasma renin activity in detection of primary aldosteronism with higher sensitivity and specificity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reproductive factors have been linked to both breast cancer and DNA methylation, suggesting methylation as an important mechanism by which reproductive factors impact on disease risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These errors reflected the inability to define the word denoting the object more often than the inability to define the nature of the pictured object. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carotid duplex ultrasound echobrightness, assessed in predefined tissue sites as a measure of arterial wall density, was significantly greater than age- and sex-matched controls in the intima-media (P<0.02), near adventitia (P<0.003), and deep adventitia (P<0.01), as was internal carotid artery mean flow velocity (P<0.0001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here, we investigated the function of local and systemic TNF in podocyte injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future studies will link swallow imaging data of this kind with physiological and anatomical data in a manner not possible with human participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there have been no controlled studies comparing patient-reported outcomes between them. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The subjects were previously randomized to either the control arm (n = 35) or the oxandrolone arm (0.1\\u2009mg/kg twice/day for 12 months, n = 19). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this randomized controlled trial, we tested the hypothesis that patient-reported outcomes are better in patients who have undergone total hip arthroplasty (THA) with PA than in those who have undergone THA with LA, 12 months postoperatively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The genetically engineered V1442E-Na channel expressed in HEK cells shows marked enhancement of fast inactivation close to the resting potential, and enhanced use-dependent inactivation on high-frequency stimulation; S246L is likely a benign polymorphism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Associations between environmental characteristics and likelihood of active commuting and public transit use were modeled using logistic regression with private transport (driving alone or carpool) as the reference category, adjusting for age, gender, and household car ownership. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Reducing DUP through better screening can decrease the psychosocial burden of disease and improve the trajectory of psychosis.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In patients at increased risk of CIN receiving prophylactic theophylline, hydration with sodium bicarbonate reduces contrast-induced renal impairment compared to hydration with saline.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Secondary outcomes were HOOS-Pain, HOOS-Quality-Of-Life, EQ-5D, UCLA Activity Score, and limping. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Before in-vivo calibration values from the CDI without gas calibration were significantly different from the ABL-values in accuracy as well as precision, whereas the results from the gas calibrated CDI were largely consistent with the ABL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The time from search to transplant was identical for transplants using a KIR-genotyped versus a non-KIR-genotyped donor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Four trajectories were identified: 73.2%(n\\u2009=\\u2009857) of the children showed a normal BMIz trajectory, 13.2%(n\\u2009=\\u2009155) a stable low-BMIz trajectory, 8.6%(n\\u2009=\\u2009100) a stable high-BMIz trajectory and 5.0%(n\\u2009=\\u200958) a rapid BMIz gain after 3 months trajectory. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Personality assessment can help a multidisciplinary gender dysphoria team detect potential psychopathological factors of vulnerability.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, they highlight the potential difficulty in replicating rare CNV associations across different populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants performed three 6-min walking trials while wearing a pair of insoles containing vibrating actuators. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Analyses of covariance did not reveal significant treatment effects for memory (Buschke immediate recall, p\\u2009=\\u20090.53; delayed recall, p\\u2009=\\u20090.94), attention (Trails A speed, p\\u2009=\\u20090.81 and errors, p\\u2009=\\u20090.22; Digit Span Forward length, p\\u2009=\\u20090.66), executive functioning (Trails B speed, p\\u2009=\\u20090.97 and errors, p\\u2009=\\u20090.93; Digit Span Backward length, p\\u2009=\\u20090.60), language (timed phonemic fluency, p\\u2009=\\u20090.05), and fine motor coordination/dexterity (Grooved Pegboard dominant hand time, p\\u2009=\\u20090.75 and peg drops, p\\u2009=\\u20090.59; nondominant hand time, p\\u2009=\\u20090.74 and peg drops, p\\u2009=\\u20090.61). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deaths were attributed to central nervous system infection (11), malaria (3), urinary tract infection (2), gastrointestinal infection (1) and undifferentiated sepsis (1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DUP was estimated using Schedules of Clinical Assessment in Neuropsychiatry (SCAN). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maximum expired ventilation (VEmax) was also measured in a subset of burned subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Background. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ongoing training was correlated with a reduction in DUP. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results suggested that genetic variants associated with HBV-related hepatocarcinogenesis may already play an important role in the progression from CHB to LC.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The expression levels of tumor necrosis factor-\u0152\u00b1 (TNF-\u0152\u00b1), interleukin-6 (IL-6), and high mobility group box 1 (HMGB1) in the cervical secretions and tissues were found to gradually increase, peaking at 2 weeks after conization, then significantly decreasing 3-6 weeks onwards. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent studies have reported multiple GSV loci associated with risk of obesity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results show that there was a positive correlation between social anxiety symptoms and age, and girls reported more symptoms. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants beliefs in General-Harm (r = -0.243; p = 0.003) and General-Overuse (r = -0.203; p = 0.012) were negatively correlated with total QAQ point. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Median length of hospital stay was 5 days. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prospective evaluation can rapidly identify KIR favorable genotype donors, but choosing more donors per search would substantially increase the likelihood of having a KIR best or better donor available for transplantation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The participants in\\nthis study were women over 20 years old, who presented to Arnavutkoy State Hospital General surgery policlinic and\\nSisli Hamidiye Etfal Family Medicine policlinic. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was inconsistent evidence supporting a sustained first-grade treatment effect: Individualized instruction in first grade was necessary but not sufficient for stronger third-grade reading outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PaO2/FiO2 ratio in the E group was superior to that in the C group in the pneumoperitoneum period, though the difference was not significant (330\\u200a\u00ac\u00b1\\u200a10 vs 305.56\\u200a\u00ac\u00b1\\u200a4\\u200amm Hg; P\\u200a=\\u200a0.09). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study aimed to explore the associations of total stroke, including ischemic and hemorrhagic type, with sleep habits of a population in southern China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Barriers to engaging in optimal energy balance focused more on motivation and attitude than on structural and material barriers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared to leukocyte subset or CRP, NLR in women with funisitis was significantly higher than in women with HCA alone and showed higher predictive accuracy, along with 71.4% sensitivity, 77.9% specificity, 80.7% positive predictive value, and 67.8% negative predictive value for prediction of PIR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Material and Methods. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found that, regardless of treatment, bone metastases appeared in a certain number of patients and that after excluding patients with prostate cancer a bone metastasis was the first sign of \"recurrence\" in 1.3% of the patients with a known primary solid malignant tumour.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The AUC for plasma renin activity, logARR, and serum aldosterone are 0.855, 0.84, and 0.501, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the combined groups, under both modes of cortisol addback, ACTH concentrations, pulsatile ACTH secretion, and ACTH secretory-burst mass correlated negatively and univariately with E2 levels (each P < 0.005). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The direct energetic nature of these relationships is indicated by (i) the manifestation of biomarker-specific negative immune effects only when examining growth over timeframes capturing active competition for energetic resources, (ii) the exaggerated impact of particularly costly inflammation on growth, and (iii) the ability of children with greater levels of body fat (i.e., energy reserves) to completely avoid the growth-inhibiting effects of acute inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ten patients had fracture before diagnosis of coeliac disease and six after diagnosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, a protocol for clinicians to manage the patient presenting with oligometastatic prostate cancer would be a useful clinical tool.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prediction of cancer progression after radical prostatectomy is one of the most challenging problems in the management of prostate cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Bivariable and multivariable linear regression were used to assess relationships between PK parameters and covariates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Median age of the 220 cases since 2015 is 2.5 years (2.5 years in intensive care cases), 94% were hospitalised, 17% (n\\xa0=\\xa038) in intensive care. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further assessment was done via Quantitative Analgesic Questionnaire (QAQ) regarding the analgesics taken. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Radiographic scoring at each time interval showed reduction in both number of nodules (P = \\u200a<0.0001) and largest nodule diameter (P =\\u200a <0.0001) in all patients for at least 18 months following B cell depletion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eating competent individuals (37%, classified by ecSI 2.0TM) had a better quality of diet (p < 0.05 for all). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conducted a secondary analysis of neuropsychological outcomes to evaluate whether progesterone is associated with improved recovery of cognitive and motor functioning. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cardiorenal Syndrome Type 5 (CRS Type 5) reflects concomitant cardiac and renal dysfunctions in the setting of a wide spectrum of systemic disorders. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings have public health implications for India and suggest that caution should be taken when translating evidence across countries.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Usually candidate genes are identified according to a gene-by-gene comparison of expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most common procedure was lobectomy (48%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In stepwise multivariate linear regression analysis, blood HIV-1 RNA level (p<0.0001) was most strongly associated with seminal plasma HIV-1 RNA level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similarly, both rs3803300 GG genotype and G allele had obvious differences between case and control groups (P\\u200a<\\u200a.05) and it was closely associated with CHD susceptibility. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We performed flow cytometric immunophenotyping in 33 patients with common variable immunodeficiency, 23 with idiopathic primary hypogammaglobulinemia and 21 with IgG subclass deficiency, as well as in 47 asymptomatic first-degree family members of patients and 101 unrelated healthy controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Seventy-nine voles (10.78%; n=733) were positive for mycobacteria, with the highest prevalence in spring (13.15%; n=327). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Group 2 consisted of ten patients who, after similar ventral removal and bone interposition, were stabilised by ventral instrumentation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We found significant difference between the groups with respect to both ACE and MTHFR genotype distributions (p< 0.001, p< 0.001 respectively). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In cardiac resynchronization therapy (CRT), left ventricular (LV) pacing is achieved by positioning the LV lead in one of the tributaries of the coronary sinus (CS). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Escherichia coli sequence type 410 (ST410) has been reported worldwide as an extraintestinal pathogen associated with resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Globally, 507 (70.7%) HCSs showed protective antibody titres, and an anamnestic response was observed in more than 95% subjects receiving the booster dose. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Blood samples were drawn from patients with particular restriction for measuring serum aldosteronism, plasma renin activity, and serum potassium. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is unclear whether dietary lutein/zeaxanthin intake in colorectal cancer is associated with microRNA processing involved in DICER1 cleavage for messenger RNA translation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, RTX therapy induces resolution of pulmonary granulomatous inflammation in GPA following prolonged B cell depletion.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multivariable survival analyses identified carcinoembryonic antigen levels (hazard ratio [HR]\\xa0=\\xa03.056; 95% confidence interval [CI]\\xa0=\\xa01.354-6.897; P\\xa0=\\xa00.007), treatment strategy (HR\\xa0=\\xa00.212; 95% CI\\xa0=\\xa00.056-0.808; P\\xa0=\\xa00.023), and CD133+ CD44+ CD54+ cellular subpopulation of CTCs (HR\\xa0=\\xa06.459; 95% CI\\xa0=\\xa01.461-28.558; P\\xa0=\\xa00.014) as independent prognostic factors for CRC patients with liver metastasis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the vaginal and cervical wound infection rates after conization in patients treated with iodoform were significantly lower than the rates in those without iodoform treatment (p<0.05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings highlight the importance of health promotion to help drivers make better choices about their health behaviors, which are often underpinned by the limitations of their work environment. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A 32-element cardiac coil was used for data acquisition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results support the notion that communal living residents may develop more tolerant attitudes by striving toward superordinate community goals (objectives held by (a) the whole group and (b) which individual members could not achieve alone).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, results from high-income countries remain inconsistent, and there has been limited research from low- and middle-income countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no difference in MCP-1 -2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; P > .05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We examined associations between the neighborhood availability (vendor density per km2 within 400\\u202fm and 1600\\u202fm buffers of households) and accessibility (distance from the household to the nearest vendor) of fruit/vegetable and highly processed/take-away food vendors with 11 cardiovascular risk factors, including adiposity measures, glucose-insulin, blood pressure, and lipid profile. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Background It is well known that white matter injuries observed at birth are associated with adverse neurodevelopmental outcomes later in life. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Their average age was 67 (range: 30-96) years and all were thoroughly investigated with a complete physical examination and laboratory tests as well as imaging studies and bone scans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This retrospective study investigated the correlation between liver tests abnormalities and treatment outcomes in patients with unresectable advanced or metastatic soft tissue sarcomas (STS) treated with trabectedin 1.5 mg/m(2) once every 3 weeks at three reference centers in Italy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study suggests that stress and parents' education level were associated with atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is seemly that the optimal blastocyst and frozen blastocyst rates was higher in the low oxygen group, but the data did not reach a statistical significance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We studied two male (Osteoporotic Fractures in Men Study [MrOS] US, MrOS Sweden) and one female (Study of Osteoporotic Fractures [SOF]) large prospective cohorts of older subjects, looking at BMD, BMD change, and radiographically and/or medically confirmed incident fractures (8067 subjects, 2185 incident nonvertebral or vertebral fractures). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Since 7 June 2018, an enterovirus D-68 (EV-D68) season (the third since 2015) is ongoing in Wales, with 114 confirmed cases thus far. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The modified extract of P. judaica is safe to treat sensitive patients, even at accelerated regimens, and induces significant immunological changes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Elderly non-fallers also demonstrated significant reductions in stride and stance time variability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A subset of severely burned pediatric subjects from a prospective clinical trial (n = 222) were included in our study (n = 54, 7-18 years, \u201a\u00e2\u202230% TBSA burn). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our simulation results show how this algorithm expands the search tree effectively and efficiently in a grid-world environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains largely unknown. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The 30-day readmission rate was 9.4%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over a number of years a stable fusion can be achieved through either operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over a 6-year period, 226 cases had both MIF and one of these other methods performed for comparison. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The search process identified a mean of 30% KIR better or best donors; the success ranged from 24% to 38% in the 11 centers enrolling \u201a\u00e2\u20228 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the incidence of itching was higher in group R (4.3%) than in group N (0.7%) (P\\u200a<\\u200a0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "B3/H24Rx appears to have evolved by the acquisition of the extended-spectrum \u0152\u2264-lactamase (ESBL)-encoding gene blaCTX-M-15 and an IncFII plasmid, encoding IncFIA and IncFIB. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The number of artificial cardiac pacemakers is increasing, as is the number of bodies being cremated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Importantly, asymptomatic first-degree family members of patients were found to have an intermediate phenotype for peripheral B- and T-cell subsets.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We tested 1,084 haplotype-tagging and functional variants from 164 genes in mitotic regulatory pathways in 791 Caucasian women with breast cancer and 843 healthy controls for association with risk of overall and high grade breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings provide evidence for immunologically and temporally diverse body fat-dependent tradeoffs between immune function and growth during childhood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In HLA-DQ2/8-positive patients, ZO-1 protein expression in the rectosigmoid mucosa was reduced compared with that in HLA-DQ2/8-negative patients and colonic transit was slower than in HLA-DQ2/8-negative patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angiogenin levels were determined by radioimmunoassay and ELISA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study was conducted by using a self-administered questionnaire among 384 adolescents (65.4% boys; M = 16.05 years, SD = 1.39) studying at secondary schools of Birgunj. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P\\u2009=\\u20091.79\\u2009\u221a\u00f3\\u200910(-2), OR\\u2009=\\u20091.17, 95% CI\\u2009=\\u20091.03-1.34; rs9267673: P\\u2009=\\u20094.91\\u2009\u221a\u00f3\\u200910(-4), OR\\u2009=\\u20091.37, 95% CI\\u2009=\\u20091.15-1.63; rs2647073: P\\u2009=\\u20093.53\\u2009\u221a\u00f3\\u200910(-5), OR\\u2009=\\u20091.63, 95% CI\\u2009=\\u20091.29-2.06; rs3997872: P\\u2009=\\u20094.22\\u2009\u221a\u00f3\\u200910(-4), OR\\u2009=\\u20091.86, 95% CI\\u2009=\\u20091.32-2.62; rs9275319: P\\u2009=\\u20091.30\\u2009\u221a\u00f3\\u200910(-2), OR\\u2009=\\u20091.32, 95% CI\\u2009=\\u20091.06-1.64). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As a result, 97 patients were chosen as subjects and divided into two groups: hepatectomy with (group A: n=50) and without (group B: n=47) pre-operative TAE. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Half consumed fewer serves of fruit and 88% consumed fewer serves of vegetables than national recommendations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Predictors of the stable high-BMIz and rapid BMIz gain trajectories were pre-pregnancy BMI, gestational weight gain, Malay and Indian ethnicity, while predictors of stable low-BMIz trajectory were preterm delivery and Indian ethnicity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A cross-sectional survey was conducted between 2014 and 2015 as part of a nationwide survey using stratified four-stage random sampling in Xinjiang. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Younger students were more likely to have atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After each blood sample the CDI was in-vivo calibrated to the values simultaneously obtained from the ABL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following propensity score matching analysis, 2582 patients were included in each group. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Methods: A total\\nof 489 patients were included in the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We evaluated whether radiologically derived measures of body composition could explain more of the interpatient variability in aminoglycoside pharmacokinetics (PK) than standard body size metrics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, ancillary analyses revealed a moderational effect of religious affiliation in the relationship between prayer and pain severity as well as pain tolerance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using a longitudinal cluster-randomized controlled design, we examined whether students' reading outcomes differed when they received 1, 2, or 3 years of individualized reading instruction from first through third grade, compared with a treated control group.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Demographic and surgical parameters were assessed, as well as the compliance with ERAS protocol elements, length of hospital stay, number of complications, and readmissions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ACTH concentrations were lower in women than men (P < 0.01), and in women in the E2+ compared with E2- group under both continuous (P = 0.01) and pulsatile (P = 0.006) cortisol feedback, despite higher cortisol binding globulin and lower free cortisol levels in women than men (P < 0.01). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chi-square analysis revealed no significant difference in the proportion of subjects (263/280 progesterone, 283/295 placebo) with Galveston Orientation and Amnesia Test scores \u201a\u00e2\u202275. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Additionally, eating competence was associated with a lower prevalence of previously undiagnosed type 2 diabetes, abdominal obesity, metabolic syndrome and hypertriglyceridaemia, and with better insulin sensitivity (p < 0.05 for all). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data from 717 subjects undergoing HbsAg Ab and HBc Ab testing during the preventive medical examination, and receiving a booster dose of HBV vaccine when resulting with a non-protective titer (<10\\xa0mIU/mL), were collected and analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transplant centers and donor registries must both commit extra effort to incorporate new characteristics (beyond HLA, age, and parity) into improved donor selection. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, circulating follicular helper T-cell frequency and expression of inducible T-cell co-stimulator and chemokine receptors were only significantly altered in patients with common variable immunodeficiency. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, among the three SNPs associated with the risk of HCV-related HCC in previous GWASs, none of them showed significant association with the risk of HBV-related LC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study suggests that HIV-infected individuals younger than 40 years and those with lower education level are more likely to have poorer QoL, while those receiving ARV treatment tend to have better QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Survival analysis supported this result, with cutaneous lesions only manifesting in the advanced stages of infection, and therefore only being found on older voles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our analysis suggests that the ST410 lineage should be classified with the potential to cause new high-risk clones. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Tranexamic acid did not have a statistically significant effect on blood loss. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During each trial, the noise stimulus was applied for 3 of the 6min, and differences in stride, stance, and swing time variability were analyzed between noise and no-noise conditions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Short, daily exposure to a psychosocial/physical stressor, during the first week of life, resulted by adulthood in significant changes in neocortical thickness and architecture, which were further modulated by exposure to behavioral testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, contrast-enhanced whole-heart CMRA at 3.0T can depict the normal and variant cardiac venous anatomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In contrast, we found no statistically significant relationship between stress and atopic dermatitis in girls.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After in-vivo calibration there was no statistical difference between the values of the CDI with and without calibration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The postoperative pulmonary complications within the first 5 days were also observed.We chose 10\\u200acm H2O and 8\\u200acm H2O as the \"ideal\" PEEP for the C and the E groups, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The complex interplay of psychosocial, structural, and physiological processes offers significant challenges to groups with entrenched health challenges.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The administration of oxandrolone was associated with improved lung function in pediatric burned patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ninety-five cases of acute Q fever were identified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No bone metastases were found at the time of the initial diagnosis, and the patients were then re-assessed every 6 months for the first 5 years and then once a year. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The assessment of co-existing psychological and psychiatric disorders is advocated in the Standards of Care for the health of transsexual people.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pulmonary nodules (median 4, range 2-6), with or without cavitation were present in all patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Self-medication with analgesics in dental pain management is a common practice as most of these medicines are available over-the-counter (OTC). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both GRS63 and GRS16 were associated with fractures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to the well-known melanoma susceptibility genes confirmed in the meta-analysis (MC1R, CDKN2A, TERT, OCA2 and ARNT/SETDB1), we also identified additional novel genes using FUMA to map SNPs to genes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Land-use mix was significantly associated with the use of public transit compared to private transport (adjusted odds ratio (aOR) =5.2, p = 0.002). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Future research should seek to implement additional evidence-based actions to improve QoL in this population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An outbreak of Q fever occurred in South Wales, United Kingdom, from July 15 through September 30, 2002. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Osteoarthritis is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The top-scoring pair (TSP) algorithm classifies phenotypes according to the relative expression of a pair of genes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The end point was BP\\xa0<\\xa0140/90\\xa0mm Hg at 6-month follow-up. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher precision was observed using a modified Cockcroft-Gault equation with skeletal muscle area at L3 (R2= 0.38) or L4 (R2= 0.37) than the standard Cockcroft-Gault equation using lean (R2= 0.23), adjusted (R2= 0.23), or total (R2= 0.22) body weights. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Delays in seeking appropriate healthcare can increase the case fatality of acute febrile illnesses, and circuitous routes of care-seeking can have a catastrophic financial impact upon patients in low-income settings.  51% of participants were classified as multidimensionally poor (MPI>0.33). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This test detects in a timely manner newborns at risk for invasive GBS disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Responders are randomized to 26 weeks of double-blind continuation treatment with 3 x 300 mg/day WS 5570 or placebo. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We retrospectively reviewed the specificity of antibodies against C. trachomatis, Chlamydia psittaci, and Chlamydophila pneumoniae by microimmunofluorescence (MIF) when compared with DFA, culture, nucleic acid probe, and transcription-mediated amplification. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the analyses of calculated risk score, BMI \u201a\u00e2\u2022 28.0 corresponded to the highest risk score of 23 points. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This retrospective study included adult patients treated with gentamicin or tobramycin with at least three drug concentrations and computed tomography (CT) imaging available. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The relative risk strength of disease based on genetic variant was revealed using odds ratio (OR) with 95% confidence interval (95%CI).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Those carrying the G allele (AG\\u2009+\\u2009GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk (OR, 95% CI\\u2009=\\u20090.32, 0.22-0.46, P for interaction\\u2009=\\u20090.018), particularly for rectal cancer (OR, 95% CI\\u2009=\\u20090.24, 0.15-0.39, P for interaction\\u2009=\\u20090.004), compared with that of AA carriers with low lutein/zeaxanthin intakes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pursuing this clue, we sequenced SCN4A encoding the skeletal muscle sodium channel (Nav1.4) and detected two heteroallelic mutations involving conserved residues not present in 400 normal alleles: S246L in the S4/S5 cytoplasmic linker in domain I, and V1442E in the S3/S4 extracellular linker in domain IV. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a cross-sectional study, 27 sites were monitored bi-annually, with TB assessed by post-mortem examination for macroscopic lesions, and by culture and histopathology. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results underline the cytotoxic effect of CRS Type 5 mediators on RTC viability, probably due to the activation of both intrinsic and extrinsic pathways of apoptosis and to the deregulation of cytokine release. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of vibrating insoles significantly reduced stride, stance, and swing time variability measures for elderly recurrent fallers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the previous study, we had showed the expression of CD133+ CD54+ CD44+ cellular subpopulation of circulating tumor cells (CTCs) was significantly associated with liver metastasis of colorectal cancer (CRC). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Because of the explosive potential of pacemakers when heated, a statutory question on the cremation form asks whether the deceased has a pacemaker and if so whether it has been removed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mean neutrophil counts, CRP levels, and NLR in both the patients with histologic chorioamnionitis (HCA) alone and those with HCA with funisitis were significantly higher than those in women with no placental inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This cross-sectional study was conducted in a French public university hospital. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conducted a retrospective cohort study of 483 patients who delivered preterm neonates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After controlling for blood HIV-1 RNA level, seminal plasma HIV-1 RNA level was positively associated with interferon (IFN)-\u0152\u2265 (p=0.03) and interleukin (IL)-17 (p=0.03) and negatively associated with IL-5 (p=0.0007) in seminal plasma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite the efficacy of aprotinin and epsilon-aminocaproic acid shown in the present study, the blood requirements were not significantly different from those that are found when transfusions are restricted, autotransfusions are used, and blood from the operative field and extracorporeal circuit is concentrated and reinfused. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both poor and non-poor households relied predominantly upon the (often informal) private sector for medical advice before reaching the referral hospital, but MPI poor participants were less likely to have consulted a qualified doctor. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These advantages result in a clinically smoother course after the operation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our aim was to study in vitro effects of CRS Type 5 plasma on renal tubular cells (RTCs), in terms of cellular death and the characterization of inflammatory plasma profile in these patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CONCLUSIONS Hysterectomy should be performed at least 4 weeks after conization. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar to other medical societies, the Society of Thrombosis and Haemostasis Research has issued empirical recommendations on initiation, dosing, and duration of pharmacological VTE prophylaxis in COVID-19 patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 335 patients were included with a median (minimum, maximum) of 4 (3, 16) aminoglycoside concentrations per patient. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During the 2011-2013 period, an observational study was performed in Healthcare students (HCSs) trained at a regional university acute-care hospital in North-Western Italy, properly immunized against HBV during infancy or adolescence, in order to evaluate the persistence of seroprotection and to assess the anamnestic response to booster vaccination. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Few studies assess built environment correlates of active commuting in low-and-middle-income countries (LMICs), but the different context could yield distinct findings. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hierarchical linear modeling (HLM) was used to examine the effect of condition (therapeutic communal living versus usual aftercare) on wave trajectories of tolerance (i.e., universality/diversity scores). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We cultured human podocytes with sera collected from DKD patients, who displayed elevated TNF levels, and focal segmental glomerulosclerosis (FSGS) patients, whose TNF levels resembled those of healthy patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angiogenesis is a key process in the pathogenesis of inflammatory arthritis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. ', \"Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). \", 'The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We also attempted replication using BMI as a quantitative trait in our population cohort; associations with BMI at or near nominal significance were detected at two further loci near KIF2B and within FOXP2, but these did not survive correction for multiple testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "By contrast, significantly higher serum aldosterone and plasma renin were observed in CKDs compared with the other two groups (P < 0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At 5 years, children with stable high-BMIz or rapid BMIz gain trajectories had increased waist-to-height ratios [B(95%CI) 0.02(0.01,0.03) and 0.03(0.02,0.04)], sum of skinfolds [0.42(0.19,0.65) and 0.70(0.36,1.03)SD units], fat-mass index [0.97(0.32,1.63)SD units] and risk of obesity [relative risk 3.22(1.73,6.05) and 2.56 (1.19,5.53)], but not higher blood pressure. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TNF-stimulated free cholesterol-dependent apoptosis in podocytes was mediated by nuclear factor of activated T cells 1 (NFATc1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ZCWPW1 (rs1476679) and CDS33 (rs3865444) variants were nominally associated with change on the DWRT and WFT in African-Americans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of the 13 patients who had a positive C. trachomatis antigen or nucleic acid test result, 9 had IgG and/or IgM titers highest against C. trachomatis, 3 had IgG titers highest against C. pneumoniae, and 1 had undetectable titers for the three chlamydial species. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Findings can guide public education to improve the safety aspects of self-medication with analgesics in dental practice.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The algorithm also provides several predictions testable in animal/human experiments.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recovery from an acute episode is followed by 4-6 months of relapse prevention. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From an epidemiological investigation of 49 E.\\xa0coli ST410 isolates from Danish patients, we identified five possible regional outbreaks, of which one outbreak involved nine patients with blaOXA-181- and blaNDM-5-carrying B4/H24RxC isolates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We sought to decrease DUP in rural Argentina by instituting annual training of local health agents to better identify signs of mental illness and offer earlier intervention. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our data indicate that LMC and STR males share with environmentally enriched males, an increase in thickness in infra-granular cortical layers, while STR also display a stress selective decrease in supragranular layers, in response to behavioral training as adults.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study sought to establish comprehensive characterization of the fatal vasculopathy in Hutchinson-Gilford progeria syndrome and its relevance to normal aging. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Effective disease treatments may be heralded by normalizing trends of these noninvasive cardiovascular measures. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This was a prospective, observational study of paired blood and semen samples from 18 HIV-1 chronically infected men off antiretroviral therapy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, we compared the postoperative numerical rating scale (NRS) of pain intensity between patients who underwent LPN and those who underwent RAPN.We included 705 patients who underwent either LPN (n\\u200a=\\u200a200) or RAPN (n\\u200a=\\u200a505) for renal tumors between January 2000 and September 2016. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Correlation of serologic titers for Chlamydia trachomatis with other tests has been based on direct fluorescence antibody (DFA) testing and culture, but not on nucleic acid-based tests that are used for screening. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results highlight that skeletal muscle measurements from CT images obtained in the course of care can improve the precision of aminoglycoside CL estimation over current body size scalars.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The measured parameters were arch length, arch width, Bolton's ratio, and arch form.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nevertheless, we show that such studies are potentially valuable for the identification of variants making an appreciable contribution to complex disease.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we investigated whether hydration with sodium bicarbonate is superior to hydration with saline in addition to theophylline (both groups) in the prophylaxis of contrast-induced nephropathy (CIN).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In fully adjusted models, higher density of fruit/vegetable vendors within 400\\u202fm of participant households was associated with lower systolic blood pressure [-0.09\\u202fmmHg, 95% confidence interval (CI): -0.17, -0.02] and diastolic blood pressure (-0.10\\u202fmmHg, 95% CI: -0.17, -0.04). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study suggests a link between age at menarche and genome wide DNA methylation, and the difference in results between the two arrays suggests that repetitive element methylation has a role in the association. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, degree of stress is positively correlated with likelihood of being diagnosed with this condition and increasing the severity.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both standard and morphomic measures poorly explained variability in volume (R2 < 0.06). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant attention has been given to the ExPEC sequence type ST131, which has been categorized as a \"high-risk\" clone. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angiogenin is one of the most potent inducers of neovascularization in experimental models in vivo. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study tests this hypothesis across diverse timeframes, branches of immunity, and conditions of energy availability among humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nor were survival outcomes significantly different in the subgroups of patients with or without ALT/AST increases or with ALT/AST elevations \u201a\u00e2\u2022 15 \u221a\u00f3 the upper limit of normal (ULN) versus those with ALT/AST elevation < 15\\u2009\u221a\u00f3\\u2009ULN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thirty (56.6%) patients tolerated an early oral diet well within 24 h postoperatively; in 48 (90.6%) patients, mobilization in the first 24 hours was successful. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We believe that transesophageal echocardiography offers the cardiologist and cardiovascular surgeon the capability of more accurate preoperative and intraoperative assessment of cardiac masses.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Cortical volumes in these areas were reduced to less than half of control values, whereas average volume elsewhere in the left hemisphere deviated from control values by only 8%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The PEEP was titrated and increased in a 2-cm H2O stepwise manner, from 6 to 14\\u200acm H2O. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We present the rationale and design of an ongoing double-blind, randomized, placebo-controlled trial investigating the efficacy of Hypericum extract WS 5570 in relapse prevention in recurrent unipolar depression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study found that individuals who practised self-medication had stronger beliefs about the benefits of medicines and weaker beliefs in viewing medicines as harmful and overused. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Three patients had osteomalacia confirmed on bone biopsy, two of whom had characteristic biochemistry. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two outstanding questions in this scheme are \"in which directions the search tree should be expanded?\", and \"when should the expansion stop?\".", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The aim of the study is to present clinical outcomes of patients with gastric cancer undergoing laparoscopic gastrectomy combined with the ERAS protocol. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TBSS analyses showed widespread clusters in major white matter tracts, with positive correlations (P \u201a\u00e2\u00a7 .05, corrected for the voxel-wise multiple comparisons) between FA values and multiple BSID subscale scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surprisingly many of the naming errors reflected pure retrieval failures, without discernible semantic or associative component. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conversely, the frequency of the SLC4A1Delta27 allele was higher in Liksul (0.0740) than the Wosera (0.0005) (chi(2); P < 0.0001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BMIz trajectories were more predictive of adiposity at 5 years than was BMIz at 2 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ABCA1 overexpression or cholesterol depletion was sufficient to reduce albuminuria in mice with podocyte-specific NFATc1 activation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although testosterone and SHBG concentrations were associated with breast cancer risk, the concentrations of these hormones were correlated with those of oestradiol; the associations were not statistically significant after adjusting for oestradiol concentration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypertension was defined as mean systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) \u201a\u00e2\u2022140/90 mm Hg and/or taking anti-hypertensive medication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results Thirty-eight full-term infants (20 boys, 18 girls) underwent MRI examination at 2 weeks of age (14.3 days \u00ac\u00b1 1.6) and BSID measurement at 2 years of age (732 days \u00ac\u00b1 6). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It is, however, associated with a relatively high risk of perioperative complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whereas common variable immunodeficiency has been investigated in depth, there are only a few reports on milder primary antibody deficiencies such as idiopathic primary hypogammaglobulinemia and IgG subclass deficiency. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of the intervention was significantly larger in patients who were younger (interaction P\\xa0=\\xa0.02), did not have diabetes (P\\xa0=\\xa0.005), had high baseline diastolic BP (P\\xa0=\\xa0.02), added salt less than daily in food preparation (P\\xa0=\\xa0.007), and took 0-2 (rather than 3-6) antihypertensive medication classes at baseline (P\\xa0=\\xa0.02). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To look for evidence that angiogenin is involved in inflammatory joint disease, we examined plasma and synovial fluid (SF) samples from rheumatology patients and synovial fibroblast cell culture supernatants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Moreover, the differences among stroke subtypes remain unclear. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although regression analysis revealed that both tests significantly predicted subjective scores on the DHI, more LOS than SOT testing variables were important predictors of DHI results indicating disability. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We investigated whether dietary lutein/zeaxanthin intake affects colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 7511 patients aged \u201a\u00e2\u2022 20 years, who underwent thyroidectomy between January 2009 and December 2013 at the Asan Medical Center were retrospectively analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Through chromatin interaction mapping, we prioritized IFNA7, IFNA10, IFNA16, IFNA17, IFNA14, IFNA6, IFNA21, IFNA4, IFNE and IFNA5; these 10 most significant genes are all involved in immune system and cytokine signaling pathways. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We further show that our algorithm can explain several behavioral patterns in animals and humans, namely the effect of time-pressure on the depth of planning, the effect of reward magnitudes on the direction of planning, and the gradual shift from goal-directed to habitual behavior over the course of training. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of self-medication with analgesics was 29.4%, with 95.6% of the participants took analgesics when necessary. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Symptoms of dizziness, unsteadiness, or imbalance have been most frequently attributed to sensory organization problems involving the use of visual, proprioceptive, and/or vestibular information for postural control. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Repeated RTX treatment in these 3 and persistent B cell depletion in the whole cohort was associated with further significant radiological improvement. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Primary care physicians especially works in lower socioeconomic\\nconditions have to tell the importance of early diagnosis of breast cancer, and properly explain breast self examination\\nand other screening tools.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we compared the prevalence of SOT versus LOS abnormalities in a cohort of 48 patients, the majority classified as having mild or moderate chronic TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To investigate the relationship between poverty and pre-hospital delays for patients with acute febrile illnesses, we recruited a cross-sectional, convenience sample of 527 acutely ill adults and children aged over 6 months, with a documented fever \u201a\u00e2\u202238.0 \u00ac\u221eC and symptoms of up to 14 days' duration, presenting to a tertiary referral hospital in Chittagong, Bangladesh, over the course of one year from September 2011 to September 2012.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypertension is a common global health problem including China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Around 2003, the carbapenem-resistant clade B4/H24RxC emerged when ST410 acquired an IncX3 plasmid carrying a blaOXA-181 carbapenemase gene. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Methods: This study is a biometric analysis of dental casts of 149 young adults recruited from different orthodontic centers in Jeddah, Saudi Arabia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gene-expression profiling is widely used to identify genes associated with such progression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "[\"Alzheimer's disease (AD) is the most common form of dementia and is characterized by impairment in memory, behavioral changes, and gradual loss of autonomy. \", 'Since there is a long latent period prior to diagnosis, the aim of this study was to determine whether twenty single nucleotide polymorphisms identified in genome-wide association analyses of AD are associated with cognitive change in 8,320 white and 2,039 African-American middle-aged adults enrolled in the prospective Atherosclerosis Risk in Communities (ARIC) study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Truck drivers are at increased risk of diet- and physical activity-related chronic diseases.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Maximum voluntary ventilation, the ratio between forced expiratory volume and forced vital capacity, and diffusion capacity were measured 6 months following burn injury, and results were compared between burned subjects with and without oxandrolone administration. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Both groups were comparable regarding baseline characteristics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Forty-seven smokers from one safety-net hospital were randomized to either a control group, in which they received a smoking cessation brochure and a list of smoking cessation resources, or a navigation group, in which they received the smoking cessation brochure, a list of smoking cessation resources, and patient navigation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the impact of trabectedin-related transaminase elevations on treatment outcomes is unclear. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Twenty-five patients had positive IgG and/or IgM titers to C. trachomatis but negative antigen test results. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most patients suffering from cancer die of metastatic disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no significant difference in NRS of pain intensity between the 2 groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This community-based participatory research (CBPR) energy balance (diet and physical activity) intervention, conducted in Appalachian Kentucky among 900+ residents, employed a wait list control cluster randomized design. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While these erythrocyte polymorphisms apparently have no effect on blood-stage malaria infection, their contribution to susceptibility to clinical malaria morbidity requires further study.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A healthy diet prevents type 2 diabetes but is often difficult to adhere to. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In summary, this study identifies novel putative melanoma susceptibility genes and provides a guide for further experimental validation of functional variants and disease-related genes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two hundred and two chronic pain (CP) patients, all members of a Flemish national patients association, completed the questionnaires. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During maximal exercise, subjects treated with oxandrolone had a significantly higher VEmax compared with untreated subjects (32.0\\u2009\u00ac\u00b1\\u20098.7\\u2009L/min vs 43.7\\u2009\u00ac\u00b1\\u200913.6 with treatment, P = .02). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The cardiac veins were finally evaluated in 48 subjects with three anatomic variations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interestingly, the educational level of parents was found to be associated with having atopic dermatitis and having more severe condition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the gene analysis, we identified 72 genes with a P < 2.5 \u221a\u00f3 10-6. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study replicated our prior findings that (a) cannabis users trying to change make many, and often rapid, transitions among use as usual, reduction, and abstinence; (b) reduction attempts are more common than abstinence attempts; (c) quit and reduction attempts are short-lived and few participants achieve long-term abstinence; (d) alcohol and drug use are not greater on abstinence days; and (e) few users seek treatment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Immune function is an energetically costly physiological activity that potentially diverts calories away from less immediately essential life tasks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The purpose of this study was to investigate the effect of subsensory vibratory noise applied to the soles of the feet on gait variability in a population of elderly recurrent fallers compared to non-fallers and young controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The frequency of the GYPCDeltaex3 allele was higher in the Wosera (0.463) than Liksul (0.176) (chi(2); P < 0.0001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, the role of germline variation in mitotic pathways and risk of cancer is not well understood. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among individuals with hypertension, 55.5% were aware of their condition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although young participants showed decreases in all variability measures, the results did not achieve statistical significance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A multiple choice and short response survey was distributed to truck drivers attending an Australian Truck Show. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Before in-vivo calibration, the CDI without gas calibration was completely unreliable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The use of laparoscopy and the Enhanced Recovery After Surgery (ERAS) protocol allows clinicians to limit surgically induced trauma, thus improving recovery and reducing the number of complications. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that multidimensional poverty is associated with greater pre-hospital delays and expenditure in this setting. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results support the importance of genital tract immunomodulation in HIV-1 transmission.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our findings on BMIz trajectories in the first 2 years suggest important ethnic-specific differences and impacts on later metabolic outcomes.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Segments with attenuation artifacts were defined as those with less than 65% uptake but with strictly normal contractility at gated SPECT and no defect reversibility from stress images. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The focus on prayer as a personal religious factor fits with the current religious landscape in Western-Europe where personal religious factors are more important than organizational dimensions of religion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The potential role of transesophageal echocardiography in the diagnosis and treatment of patients with intracardiac masses is discussed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Opioid requirement was different between the 2 groups on postoperative day (POD) 0 (12.4 vs 11.3\\u200amg of morphine-equivalent dose), but not from POD 1 to POD 4. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carotid-femoral pulse wave velocity was dramatically elevated (mean: 13.00\u00ac\u00b13.83 m/s). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Exogenous TNF administration or local TNF expression was equally sufficient to cause free cholesterol-dependent apoptosis in podocytes by acting through a dual mechanism that required a reduction in ATP-binding cassette transporter A1-mediated (ABCA1-mediated) cholesterol efflux and reduced cholesterol esterification by sterol-O-acyltransferase 1 (SOAT1). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neonatal stress, in particular, has been linked to the etiology of mental health disorders as divergent as mood disorder, schizophrenia, and autism. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Robot-assisted partial nephrectomy (RAPN) has emerged as an alternative to laparoscopic partial nephrectomy (LPN) for removal of renal tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serum levels of leukocyte differential counts, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were compared between women with no placental inflammation and women with PIR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition to blood HIV-1 RNA level, cytokine profiles in the male genital tract are associated with HIV-1 RNA levels in semen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using a prospective mixed-longitudinal design, we collected anthropometric and blood immune biomarker data from 261 Amazonian forager-horticulturalist Shuar children (age 4-11 y old). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In Papua New Guinea (PNG), the Gerbich-negative phenotype is caused by an exon 3 deletion in the glycophorin C gene (GYPCDeltaex3) while heterozygosity for a 27-base pair deletion in the SLC4A1 gene (anion exchanger 1 or erythrocyte membrane protein, band 3), SLC4A1Delta27, results in Southeast Asian ovalocytosis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The accumulated multidrug resistance in E.\\xa0coli ST410 over the past two decades, together with its proven potential of transmission between patients, poses a high risk in clinical settings, and thus, E.\\xa0coli ST410 should be considered a lineage with emerging \"high-risk\" clones, which should be monitored closely in the future.IMPORTANCE Extraintestinal pathogenic Escherichia coli (ExPEC) is the main cause of urinary tract infections and septicemia. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The sensitivity and specificity of the Xpert GBS were 80% and 100%, respectively, with regard to 20 cases of GBS colonization or infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Replication tests in more generalizable samples and of longer duration are indicated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "About 13% of asymptomatic relatives had an abnormal peripheral B-cell composition. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our objective was to compare gastrointestinal barrier function, mucosal inflammation, and transit in nonceliac IBS-D patients and assess association with HLA-DQ2/8 status. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most (80%) undertook less than moderate- and vigorous-intensity physical activity levels provided in national recommendations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The results showed that LogARR values were significantly higher (P < 0.001), and PRA and serum potassium values were significantly lower (P < 0.001) in primary aldosteronism patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this report, we review the echocardiographic findings, clinical history, and histopathologic findings in 21 patients with intracardiac masses who underwent transthoracic echocardiography, transesophageal echocardiography, or both, at our institution. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Blood sampling was done at the beginning of bypass, and 30 minutes later. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this study, we evaluated the clinical usefulness of maternal serum inflammatory markers for prediction of PIR in women with impending preterm birth. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Traditional induction therapy includes methotrexate or cyclophosphamide, however, pulmonary nodules generally respond slower than vasculitic components of disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Groups were compared with respect to fertilization rates, embryo development, and reproductive outcome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although predicted survival following the appearance of a cutaneous lesion was lower than for uninfected individuals, this was not significant.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There has been a growing burden of anxiety among Nepalese adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results: The biker position was associated with lower heart-to-detector distances than the supine or sitting positions (both P < 0.001); lower cardiac motion amplitudes, assessed on panograms, than the supine position (P < 0.001); and fewer segments with attenuation artifacts than the supine position (on average, 1.10 \u00ac\u00b1 1.01 vs. 1.90 \u00ac\u00b1 1.74, P = 0.010) or the sitting position (0.75 \u00ac\u00b1 0.93 vs. 1.38 \u00ac\u00b1 1.60, P = 0.011). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To enhance potential efficacy and effectiveness, interventionists increasingly respond to community priorities, employ comprehensive theoretical frameworks, invest heavily to ensure cultural fit, implement evidence-based programming, and deploy research gold standards. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Thus, with the clonal expansion over the past decades and increased antimicrobial resistance to last-resort treatment options, ST410 needs to be monitored prospectively.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The consequence may be the damage of distant organs which lead to the worsening of condition of patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The prevalence of tooth size discrepancy in all cases was 43.6% for anterior ratio and 24.8% for overall ratio. ', \"The mean Bolton's anterior ratio in all malocclusion classes was 79.81%, whereas the mean Bolton's overall ratio was 92.21%. \", \"There was no significant difference between males and females regarding Bolton's ratio.\\xa0\", 'Conclusion: The most prevalent arch form was narrow tapered, followed by narrow ovoid. ', \"Males generally had larger dental arch measurements than females, and the prevalence of tooth size discrepancy was more in Bolton's anterior teeth ratio than in overall ratio.\"]", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, few studies have investigated the link between reproductive factors and DNA methylation in humans. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sleep habits are associated with stroke in western populations, but this relation has been rarely investigated in China. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We investigated potential associations between seminal plasma cytokine levels and viral concentration in the seminal plasma of HIV-1-infected men. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "General linear models were used to assess mean differences in 6-year change in test scores among individuals categorized by genotype after adjusting for age, gender, and years of education. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eating competence is an indicator of food acceptance, positive attitudes, internal regulation and contextual skills related to food and eating. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The secondary endpoints were opioid requirement, opioid-related complications, and duration of hospital stay.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over 85% of survey respondents worked more than 9 hrs per day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Angiogenin protein was released by cultured synovial fibroblasts from OA and RA patients, and reached 1.18 ng/106 cells/day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with the 1-2-week group, the 4-5-week and 6-week groups exhibited significantly lower infection rates (2/42, 4.8%, 4-5-week group; 0%, 0/33, 6-week group; vs. 41/95, 43.2%, 1-2-week group; p<0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The genes associated with melanoma risk were DEF8 (P = 1.09 \u221a\u00f3 10-57), DBNDD1 (P = 2.19 \u221a\u00f3 10-42), SPATA33 (P = 3.54 \u221a\u00f3 10-38) and MC1R (P = 1.04 \u221a\u00f3 10-36). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two geographically and ethnically distinct malaria endemic regions of PNG (the Wosera [East Sepik Province] and Liksul [Madang Province]) were studied to illustrate the distribution of two prominent deletion polymorphisms (GYPCDeltaex3 and SLC4A1Delta27) and to determine if the genetic load associated with SLC4A1Delta27 would constrain independent assortment of GYPCDeltaex3 heterozygous and homozygous genotypes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, limping was more pronounced in the LA patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This is almost double the proportion found in the general population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 5,550 boys and 6,964 girls reported having been diagnosed with atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gestational age at birth appeared to be a confounding factor as TBSS-observed correlations weakened when it was included as a covariate; however, after controlling for gestational age at birth, ROI analyses still showed positive correlations (P \u201a\u00e2\u00a7 .05, R = 0.35 to 0.48) between mean FA in many white matter ROIs and BSID cognitive, language, and motor scores. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Whether white matter developmental variations in healthy newborns are also associated with changes in later neurodevelopment remains to be established. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The odds ratio for breast cancer in the top third compared with the lowest third of the oestradiol concentration distribution was 5.03 (95% confidence interval 2.02-12.49, P for trend < 0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genome-wide association study (GWAS)-identified single-nucleotide polymorphisms (SNPs) are tag SNPs located in both transcribed and non-coding regulatory DNA regions, rather than representing causal or functional variants for disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Concordance of Xpert GBS results versus culture was 92.3%. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Among the 351 trial participants, 44% were female, 84% non-Hispanic white, mean age was 60.9\\xa0years, and mean BP was 149/86\\xa0mm Hg. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Xpert GBS real-time PCR assay was applied to gastric fluid samples from 143 newborns, and it detected group B streptococcus (GBS) within 1 h for 16 (11.2%) cases, while microscopic examination detected only 2 cases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Until genomic data exist to provide a biological component to the definition of oligometastatic disease, a clinical diagnosis made on the basis of up to five extrapelvic lesions is reasonable for use. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The geographic overlap between the prevalence of erythrocyte polymorphisms and malaria endemicity is thought to be an example of natural selection on human populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This retrospective study examined 26 years of experience in a pediatric institution (1981-2007) in pain management as long as 6 months after limb-sparing surgery and reviewed the historical evolution of pain interventions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Receiver operating characteristic (ROC) curve of ARR was tested to establish cutoff values and to assess sensitivity and specificity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Placebo or ketoconazole (KTCZ) was administered overnight to inhibit adrenal steroidogenesis during overnight 14-h intravenous infusions of saline or cortisol in a continuous versus pulsatile manner to test for feedback differences. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Considering the advantages and disadvantages of continuous remifentanil infusion, volatile anesthesia without opioid may be a good choice for minor surgeries, such as thyroidectomy.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Choosing more donors for confirmatory HLA and KIR haplotype identification enriched the likelihood of finding KIR better or best donors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Carrying G allele (AG\\u2009+\\u2009GG) showed a significantly reduced colorectal cancer incidence compared with that of AA carriers (OR, 95% CI\\u2009=\\u20090.71, 0.55-0.91). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The effect of grade 3/4 elevations in alanine aminotransferase (ALT) or aspartate aminotransferase (AST) during the first two cycles and at any time during trabectedin treatment on progression-free survival (PFS) and overall survival (OS) were analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ordinal logistic regression analyses were conducted to determine the relationship between stress and atopic dermatitis with severity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Most of the HCSs (74.6%) included in the survey, mean age 24.8\\xa0y ( \u00ac\u00b1 4.6 SD), had received the primary vaccination course during the first year of life (3-5-11\\xa0months). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Agreement between C. trachomatis antigen or nucleic acid detection and MIF results was 87% (197/226). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, because our analysis was based on a relatively small number of genes, a larger study will be needed to identify the best predictors of disease outcome overall.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Statistical analyses were performed using SPSS version 24, with 0.05 as level of significance. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 355 Liksul residents, independent assortment of these two deletion polymorphisms resulted in 14 SLC4A1Delta27 carriers heterozygous for GYPCDeltaex3 and one SLC4A1Delta27 carrier homozygous for GYPCDeltaex3 (Fisher's exact test; P = 0.8040).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It was a prospective, randomized, double-blinded study in a university hospital on 2 general intensive care units (63% of investigations) and normal wards.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We recorded outcome measures preoperatively and 3, 6, and 12 months postoperatively using the Hip Disability and Osteoarthritis Outcome Score-Physical Function Short Form (HOOS-PS) as the primary outcome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here we propose a principled solution to these questions based on a speed/accuracy tradeoff: deeper expansion in the appropriate directions leads to more accurate planning, but at the cost of slower decision-making. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study results showed the following factors as predictors of good general QoL: antiretroviral (ARV) treatment (prevalence ratio (PR)=2.87 (95% CI: 1.45, 5.67)); higher education level (PR\\u2009=\\u20091.51 (95% CI: 1.05, 2.17)); CD4 cells \u201a\u00e2\u2022200\\u2009cells/mm3 (PR\\u2009=\\u20091.83 (95% CI: 1.13, 2.94)); and age \u201a\u00e2\u202240 years (PR\\u2009=\\u20091.60 (95% CI: 1.09, 2.36)). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surprisingly, cortical size in LMC mice was also affected. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that improving emotion regulation, dispositional mindfulness, and social support may be helpful for adolescents who are at risk of, or are suffering from, social anxiety.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The final sample had a median age of 31\\u2009years and included 54 (50%) Female-to-Male individuals. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Nine (47.4%) of 19 of navigation group participants had engaged in smoking cessation treatment by 3 months versus 6 (42.9%) of 14 control group participants (chi-square p = ns). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The V1442E mutation in SCN4A defines a novel disease mechanism and a novel phenotype with myasthenic features.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "T had no univariate effect but was a positive correlate of ACTH when assessed jointly with E2 (negative) under cortisol pulses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patient navigation to promote engagement in smoking cessation treatment was feasible and acceptable to participants.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Placental inflammatory response (PIR) is associated with adverse neonatal outcomes such as sepsis, cerebral palsy, low birth weight, preterm birth, and neonatal mortality. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study demonstrated the long-term persistence of protection of HBV vaccine, more than 20\\xa0y following the primary immunization, in HCSs who are exposed to occupational health risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These observations were compared to the effects of environmental enrichment in the same mouse strain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Transesophageal echocardiography and 2-dimensional transthoracic echocardiography have proved to be extremely valuable in the diagnosis of cardiac masses. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Beside rare monogenic forms, the majority of cases seem to have a more complex genetic basis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This practice has to be performed during the preventive medical examination, before the worker's exposure to biological hazards, as a fundamental part of Occupational Health Surveillance Programs in several Countries, including Italy: the goal is to assure individual protection, also providing booster doses when needed, after many years following the primary vaccination.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although liver tests abnormalities are common in patients treated with trabectedin, elevations in ALT and AST are usually transient, occur during the first two cycles of treatment, and do not appear to affect survival.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Secondary and tertiary hyperparathyroidism were seen. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The C group patients experienced 8.7% postoperative pulmonary complications versus 5.3% among the E group patients (relative risk 1.27, 95% confidence interval 0.31-5.3, P\\u200a=\\u200a0.75).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Public health policies regarding neighborhood food environments should be encouraged in south India and other rural communities in south Asia.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Fifty patients were randomly assigned to the control (C) group and the EIT (E) group (n\\u200a=\\u200a25 each). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The authors examine differential changes in values of tolerance among 150 participants discharged from inpatient treatment centers, and randomly assigned to either a self-help-based, communal living setting (i.e., Oxford House), or usual aftercare. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These effects were achieved by regular classroom teachers who received professional development, which indicates that policies that support the use of evidence-based reading instruction and teacher training can yield increased student achievement.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although HCV is more prevalent among people with severe mental illness (SMI; e.g., schizophrenia, bipolar disorder) than in the general population (17% vs 1%), no large previous studies have examined HCV screening in this population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We hypothesized that the old and parkinsonian rats would manifest deficits in deglutition behaviors analogous to those found in human clinical populations. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These problems can be assessed with the Sensory Organization Test (SOT).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This prospective randomized study assessed myocardial perfusion imaging with the high-sensitivity D.SPECT cadmium-zinc-telluride camera in a forward-leaning bikerlike position, which may potentially lower diaphragmatic attenuation and reduce breathing-related cardiac motion, in a manner comparable to the prone position proposed with other SPECT cameras. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, these associations, except for metabolic syndrome, were at least partly mediated by body mass index. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of concern, almost 90% of drivers had above the recommended body mass index---approximately 60% were obese. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hutchinson-Gilford progeria syndrome is a rare, segmental premature aging syndrome of accelerated atherosclerosis and early death from myocardial infarction or stroke. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, within 1600\\u202fm buffer, only association with blood pressure remained robust. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Twelve young participants were included as controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This cross-sectional study investigated associations between home neighborhood environment characteristics and active commuting in Chennai, India. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The area under the receiver operation curve for the multivariable prediction model was 0.803 (95%CI: 0.789-0.813).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A more likely arrangement entails two highly interactive routes--a strongly left lateralized temporosylvian language network for verbal concepts, and a presumably more bilateral or right-sided inferotemporal/fusiform object recognition network, which remained relatively spared because peak atrophy sites were concentrated on the left. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was a significantly positive correlation between LogARR and serum potassium (r = -0.0345, P < 0.001, R(2) = 0.093). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Treatment with iodoform would be beneficial.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "346 (70.8%) of the\\nparticipants were married. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients (n = 5) with persistent pulmonary nodules were identified from our clinic database and retrospectively evaluated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We discuss the implications of this work for understanding human developmental energetics and the biological mechanisms regulating variation in human ontogeny, life history, and health.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "At 6 months, subjects underwent evaluation of memory, attention, executive functioning, language, and fine motor coordination/dexterity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sixty-one women who developed breast cancer an average of 7.8 years after blood collection were matched for age, year of blood collection and number of years post-menopausal with 179 control subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Morphomic data were extracted from CT images using a custom algorithm. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Incidence of CIN was significantly less frequent with bicarbonate compared to sodium hydration (1/74 [1.4%] vs 7/78 [9.0%]; P\\u200a=\\u200a0.035). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients who had a fracture were older (56.3 v 50.3 years, p < 0.02, Wilcoxon rank sum test) than those with no fracture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The clinical data and genotypes, alleles between 2 groups were compared by \u0153\u00e1 test and the genotype distributions in the control group were checked by Hardy-Weinberg equilibrium. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study aimed to explore whether this subpopulation of CTCs have a prognostic value in CRC patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Enrolled patients were divided into 2 groups: group N (no intraoperative remifentanil and only volatile maintenance anesthesia) and group R (intraoperative remifentanil infusion including total intravenous anesthesia and balanced anesthesia). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The incidence of opioid-related complications and duration of hospital stay were not significantly different between the 2 groups.Postoperative pain was not significantly different between patients who underwent RAPN and those who underwent LPN. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Voxel-wise correlation analyses of fractional anisotropy (FA), measured with diffusion tensor MRI, and neurodevelopmental test scores, measured by using BSID, were performed by using tract-based spatial statistics (TBSS), followed by region-of-interest (ROI) analyses of correlations between mean FA in selected white matter ROIs and each BSID subscale score. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BACKGROUND This study was conducted to observe the influence of different time intervals between prior cervical conization and posterior hysterectomy on postoperative infection in female patients with cervical intraepithelial neoplasia or cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Purpose To evaluate whether developmental variations of white matter microstructures identified by MRI correlate with neurodevelopmental outcomes in healthy full-term infants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An unweighted genetic risk score aggregating the risk alleles for 15 polymorphisms was not associated with change in cognitive function. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Modified Poisson regression with robust variance estimates was performed to create a predictive model of factors that influenced QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "For each yearly increase in age at menarche, the risk of having genome wide methylation below median level was increased by 32% (OR:1.32, 95%CI:1.14-1.53). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Social anxiety in particular is one of the commonly reported symptoms indicating mental health problem among adolescents. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Excessive taxonomic interference was observed for picture-word, but not picture-picture, matching tasks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, none of these associations were significant after Bonferroni correction for multiple testing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After a one-week wash out patients receive 3 x 300 mg/day WS 5570 single-blind for 6 weeks. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Vaccination against Hepatitis B Virus (HBV) became mandatory in Italy for all newborns and 12\\xa0years-old individuals in the 1991. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survey was completed by 231 truck drivers---almost all were male, with a mean age of 46 (range 20 to 71) years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Subjects treated with oxandrolone had a significantly higher maximum voluntary ventilation (98\\u2009\u00ac\u00b1\\u200953\\u2009L/min vs 115\\u2009\u00ac\u00b1\\u200956 with treatment, P = .03). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the 1-2-week group in particular, the postoperative infection rate after laparoscopic hysterectomy was significantly higher than the rate after abdominal hysterectomy (21/35, 60% vs. 20/60, 33%, p=0.0177). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Following students, we randomly assigned their teachers each year to deliver individualized reading instruction or a treated control condition intervention focused on mathematics. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A consistent approach to the dosing of aminoglycosides across the modern body size distribution has been elusive. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Neither mutation was associated with altered susceptibility to asymptomatic Plasmodium falciparum or P. vivax infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Time course of serum creatinine was more favorable in group B with decreases in serum creatinine after 24\u201a\u00c4\u00e4h (-0.084\u201a\u00c4\u00e4mg/dL [95% confidence interval: -0.035 to -0.133\u201a\u00c4\u00e4mg/dL]; P\u201a\u00c4\u00e4=\u201a\u00c4\u00e40.008) and 48\u201a\u00c4\u00e4h (-0.093\u201a\u00c4\u00e4mg/dL (-0.025 to -0.161\u201a\u00c4\u00e4mg/dL); P\u201a\u00c4\u00e4=\u201a\u00c4\u00e40.007) compared to baseline which were not observed in group S.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The purpose of this retrospective study was to investigate the incidence of bone metastases as the first sign of metastatic spread in patients with primary solid malignant tumours. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results: The rate and duration of breastfeeding were higher among\\nparticipants living in rural areas than those living in urban areas (p<0.001) The awareness of breast cancer increased as\\nthe level of education increased (p<0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, they were asked to fill in self-assessment questionnaires such as the short-form (SF)-36 health survey, the Oswestry questionnaire, and the visual analog scales (VAS). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Indications for blood transfusion were hypotension, tachycardia, or both, with hemoglobin values < 8.5 g/dL; or severe anemia with hemoglobin values < 7 g/dL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The mean age of participants was 36.53 \u00ac\u00b1 11.22 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The duration of untreated psychosis (DUP) is a key determinant in the severity of symptoms in patients with schizophrenia. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patients prospectively underwent clinical and radiological studies. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There were no statistically significant differences in NRS scores on postoperative days 1, 2, and 3 between the 2 groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Accumulating evidence indicates that patients with COVID-19 are at significant risk of thromboembolic complications, mainly affecting the venous, but also the arterial vascular system. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is a considerable prevalence of hypertension among Xinjiang adults, northwest China; awareness of hypertension is low. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adults with moderate to severe TBI were randomized to receive intravenous progesterone or placebo within 4\\u2009h of injury for a total of 4 days. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Compared with a normative database provided by the balance testing manufacturer, a larger portion of our cohort presented abnormalities in the LOS test. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Net reclassification improvements with the addition of the GRSs to a base model were modest and substantially attenuated in BMD-adjusted models. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, E.\\xa0coli ST410 was investigated in a global context to provide further insight into the acquisition of the carbapenemase genes blaOXA-181 and blaNDM-5 of this successful lineage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Adults (N = 370, 47.2% female, mean age =37.9 years) were recruited from 155 wards in the metropolitan area of Chennai in southern India between January and June 2015. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Such a program should integrate referral to an eye care professional for confirmation and management of vision disorders of at-risk children found on screening.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, anthropometric and laboratory measurements were performed at primary healthcare centres. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "When BMD is known, the clinical utility of the two GRSs for fracture prediction is limited in elderly subjects.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The median HIV-1 RNA concentrations were 4.42 log10 copies/ml (IQR 2.98, 4.70) and 2.96 log10 copies/ml (IQR 2, 4.18) in blood and seminal plasma, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RESULTS Mean operative time was 296.4\u00ac\u00b198.9 min, and mean blood loss was 293.3\u00ac\u00b1213.8 mL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Having a family history of a high incidence of breast cancer significantly\\nincreased the rate of breast self examination practice by 1.93 fold (p=0.016). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Deletion of a 220 kb region on chromosome 16p11.2 has a carrier population frequency of 2\u221a\u00f310(-4) (95% confidence interval [9.6\u221a\u00f310(-5)-3.1\u221a\u00f310(-4)]); accounts overall for 0.5% [0.19%-0.82%] of severe childhood obesity cases (P = 3.8\u221a\u00f310(-10); odds ratio = 25.0 [9.9-60.6]); and results in a mean body mass index (BMI) increase of 5.8 kg.m(-2) [1.8-10.3] in adults from the general population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "See also the editorial by Hu and McAllister in this issue.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study uses a Balb/CByJ mouse model to test the hypothesis, that neonatal stress will alter development and subsequent environmental modulation of neocortex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aminoglycoside volume and clearance (CL) estimates were computed using a two-compartment model by Bayesian analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study was designed to evaluate the value of contrast-enhanced whole-heart coronary MRA (CMRA) at 3.0T in depicting the cardiac venous anatomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent reports suggested that relative expression of a gene pair more efficiently predicts cancer progression than single-gene analysis does. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Excess weight loss may be a vital strategy for controlling hypertension, particularly if accompanied with other preventive measures in this region.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Daily users (n = 193) who intended to stop or reduce sometime in the next 3 months called an Interactive Voice Response system each morning for 3 months to report on cannabis use, attempts to stop or reduce, withdrawal symptoms, and so forth, on the prior day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conclusion: Myocardial perfusion images from D.SPECT are enhanced for patients positioned in a forward-leaning bikerlike position comparatively to sitting or supine positions, with a notably lower rate of attenuation artifacts.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Totally 6722 subjects aged \u201a\u00e2\u202218 years were enrolled and prevalence of hypertension was 24.3%, while the prevalence of hypertension based on the 2017 ACC/AHA guideline was approximately twice as high as that based on 2010 Chinese guideline (37.6%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study investigated the relationship between level of stress in middle and high school students aged 12-18 and risk of atopic dermatitis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CONCLUSIONS The combination of laparoscopy and the ERAS protocol in patients with gastric cancer is feasible and allows achieving good clinical outcomes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A recent large-scale meta-analysis identified 63 autosomal single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD), of which 16 were also associated with fracture risk. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Case fatality was 5.9% vs. 0.8% in poor and non-poor individuals respectively (P = 0.001)-5.1% vs. 0.0% for poor and non-poor adults (P = 0.010) and 6.4% vs. 1.8% for poor and non-poor children (P = 0.083). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A retrospective observational analysis involves 253 attendees from Urology Department of Chengdu Military General Hospital (China), comprising 146 patients with confirmed primary aldosteronism, 56 patients with essential hypertension, and 55 patients with chronic kidney disease accounting for primary kidney disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To identify functional variants or genes for melanoma susceptibility, we used functional mapping and annotation (FUMA) to perform functional annotation of the summary statistics of 2541 significant melanoma risk SNPs (P < 5 \u221a\u00f3 10-8) identified by GWAS. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further, the findings can be framed within the transactional theory of stress and coping as the results indicate that positive re-appraisal might be an important underlying mechanism in the association between prayer and pain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pain scores based on numeric rating scales (NRS) were compared between the 2 groups at the postoperative anesthetic care unit and at the ward until 3 days postoperation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a myasthenic syndrome associated with fatigable generalized weakness and recurrent attacks of respiratory and bulbar paralysis since birth, nerve stimulation at physiologic rates rapidly decremented the compound muscle action potential. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The postoperative follow-ups were at 6 months, 2 years and 5.4 years. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, as head trauma can affect any brain region, areas responsible for voluntary control of movements involved in dynamic balance tasks, such as the motor cortex and its projections, could also be compromised, which would likely affect one's limits of stability.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Efficacy of rituximab (RTX) solely for the treatment of pulmonary nodules has not been assessed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GRS63 is associated with BMD, but not BMD change, suggesting that the genetic determinants of BMD differ from those of BMD change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The remaining set of errors had associative components. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In a separate task where the same object had to be linked to verbal or non-verbal associations, performance was abnormal only in the verbal format. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The outbreak may have been caused by aerosolization of Coxiella burnetii spore-like forms during drilling into contaminated straw board.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Higher density of highly processed/take-away food vendors within 400\\u202fm of participant households was associated with higher Body Mass Index (0.01 Kg/m2, 95% CI: 0.00, 0.01), waist circumference (0.22\\u202fmm, 95% CI: 0.05, 0.39), systolic blood pressure (0.03\\u202fmmHg, 95% CI: 0.01, 0.06), and diastolic blood pressure (0.03\\u202fmmHg, 95% CI: 0.01, 0.05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We prioritized 330 unique genes, including those in immune cytokine signaling pathways, from 19 loci through positional, expression quantitative trait locus, and chromatin interaction mapping. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the treatment of pulmonary diseases due to nontuberculous mycobacteria (NTM) requires the long-term use of antibiotics in combination, the treatment success rates are unsatisfactory. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Menarcheal age was inversely associated with global DNA methylation as measured with LUMA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The patients were randomized to 1 of 4 intraoperative treatment regimens: 1) control (no antifibrinolytic therapy); 2) epsilon-aminocaproic acid (10 g IV at induction of anesthesia, followed by infusion of 2 g/h for 5 hours); 3) tranexamic acid (10 mg/kg IV within 30 minutes after induction of anesthesia, followed by infusion of 1 mg/kg per hour for 10 hours); or 4) high-dose aprotinin (2 million KIU IV at induction of anesthesia and 2 million KIU added to the extracorporeal circuit, followed by infusion of 500 thousand KIU/h during surgery). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hypericum extract, with its favourable tolerability profile, could be an interesting option for long-term prophylaxis. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The primary endpoint was postoperative NRS of pain intensity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The manufacturer of the CDI 500 in-line blood gas monitor recommends gas calibration before use. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The highest quartile of lutein/zeaxanthin consumption was inversely associated with a reduced colorectal cancer risk (OR, 95% CI\\u2009=\\u20090.25, 0.18-0.36). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hemodynamic variables, respiratory mechanics, EIT images, analysis of blood gas, and regional cerebral oxygen saturation were recorded. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Three patients had no skeletal symptoms and normal routine calcium biochemistry but severely reduced axial bone mineral density on DEXA. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The outcomes of 46 patients who underwent conization with iodoform gauze inside the vagina were observed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TB prevalence varied, with between 0% and 50% of voles infected per site. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "If, in the individual case, ventral instrumentation is feasible, this method should be used.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This paper reports subgroup analysis of a successful cluster-randomized trial to identify attributes of hypertensive patients who benefited more or less from an intervention combining blood pressure (BP) telemonitoring and pharmacist management. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Serologic testing can increase the sensitivity of detecting C. trachomatis infections.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Asymptomatic first-degree family members of patients demonstrated similar, albeit intermediate, alterations in na\u221a\u00d8ve and memory B- and T-cell subsets. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "[\"Dysphagia is commonly associated with aging and Parkinson disease and can have a significant impact on a person's quality of life. \", 'In some cases, dysphagia may be life-threatening. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sixteen had a past history of fractures (chi(2) = 10.7, p = 0.0004, v controls), which were of typical osteoporotic type. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Plasma cytokine profile of CRS Type 5 patients was significantly different from controls: we observed the production of pro- and anti-inflammatory mediators in these patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There is abnormal barrier function (increased SB permeability and reduced mRNA expression of TJ proteins) in IBS-D relative to health that may be, in part, related to immunogenotype, given reduced ZO-1 protein expression in rectosigmoid mucosa in HLA-DQ2/8-positive relative to HLA-DQ2/8-negative patients.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Relative expression of TPD52L2/SQLE and CEACAM1/BRCA1 gene pairs identified those patients with more than 99% specificity but relatively low sensitivity (approximately 10%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "During cardiopulmonary bypass blood gases can be analyzed with laboratory equipment or with an in-line monitor giving instant results. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Interpretation of these results should consider the particular animal model, lesion type, and videofluorographic protocol used in this work. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The dental arch\\xa0dimensions were measured. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Seventy five further patients (60 female) with coeliac disease (mean age 52.0 years, median duration of gluten-free diet 3.4 years) and 75 paired healthy age and sex matched controls were questioned on past fracture history. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Conclusions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "It currently relies on multiple \"layers\" of pharmacologic and nonpharmacologic strategies to address the complex mixed nociceptive and neuropathic mechanisms of pain in this patient population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We performed a prospective randomized observational study using a study group without gas calibration (29 patients) and a control group with gas calibration (29 patients). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The novel coronavirus, SARS-CoV-2, is causing a global pandemic of life-threatening multiorgan disease, called COVID-19. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our results supported our hypothesis in that the old group demonstrated reductions in bolus transport speeds and mastication rate while the parkinsonian rats showed impairments in oral processing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "\u00ac\u00a9 RSNA, 2019 Online supplemental material is available for this article. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Dizziness Handicap Inventory (DHI) results indicated mild disability, with the five activities most frequently endorsed as problematic being: looking up, performing quick head movements, performing ambitious such as sports or dancing activities, feeling frustrated, and performing strenuous house/yard work. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor participants were more likely to attribute delays in decision-making and travel to a lack of money (P<0.001), and more likely to face catastrophic expenditure of more than 25% of monthly household income (P<0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The visibility of the cardiac veins was graded visually using a 4-point scale (1: poor-4: excellent). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of the 23 patients, 10 had Mycobacterium avium-intracellulare complex infection, 12 had M. abscessus infection, and one had M. xenopi infection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pulmonary nodule formation is a frequent feature of granulomatosis with polyangiitis (GPA). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two gene pairs can predict which men would experience progression to the metastatic form of the disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients with coeliac disease underwent detailed studies of calcium biochemistry, dietary intake, and bone mineral density. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study aimed to explore the combined association between AKT serine/threonine kinase 1 (AKT1) polymorphisms and congenital heart disease (CHD) risk, meanwhile, the role of AKT1 single polymorphism on CHD was also analyzed.In the first, AKT1 polymorphisms were genotyped in 130 CHD patients and 145 healthy people with the way of polymerase chain reaction-direct sequencing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The optimal referral criteria for use in Hawai'i will need to be determined after considering the age of the screening population and the available medical resources in Hawai'i. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Expanding deep trees, however, is computationally taxing. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The indications for surgery were antibiotic therapy failure (n=11), remnant cavitary lesion with high probability of relapse (n=8), and massive hemoptysis (n=4). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Two accelerated schedules were tested in 45 P. judaica-allergic patients: 20 patients reached the maximum dose after two visits using two different concentrations and 25 patients reached the maximum dose after only one visit with two injections of the maximum concentration vial. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Electrical impedance tomography represents a new promising technique that could enable anesthesiologists to assess regional ventilation of the lungs and optimize global oxygenation for patients undergoing laparoscopic abdominal surgery.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The present study explored in a sample of Flemish pain patients the role of prayer as a possible individual factor in pain management. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Caspase-3, caspase-8, and caspase-9 were activated in cells treated with CRS Type 5 plasma compared to controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of each SNP with the risk of HBV-related LC was assessed by meta-analysis of the two cohorts. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Flow cytometry was used to detect the expression of cellular subpopulations of CTCs with CD133, CD54, and CD44 in 152 CRC patients, between December 2013 and October 2014. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The primary outcome measure is the time to relapse during continuation treatment (HAMD > or = 16, clinical diagnosis of depression, or premature treatment termination for inefficacy). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our study is framed in the transactional theory of stress and coping by testing first, whether prayer was related with pain severity and pain tolerance and second, whether cognitive positive re-appraisal was a mediating mechanism in the association between prayer and pain.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Correlational analyses showed that prayer was significantly related with pain tolerance, but not with pain severity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 1254 oocytes from 92 patients treated with conventional in vitro fertilization (IVF) were harvested in this study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Recent genome-wide associated studies (GWASs) have revealed several common loci associated with the risk of hepatitis B virus (HBV)- or hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "[\"The limited ability of common variants to account for the genetic contribution to complex disease has prompted searches for rare variants of large effect, to partly explain the 'missing heritability'. \", 'Analyses of genome-wide genotyping data have identified genomic structural variants (GSVs) as a source of such rare causal variants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specific antibody levels against native extract and rPar j 2 allergen were evaluated at the beginning and the end of the study. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants were interviewed every 6 months for a 24-month period. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Oocytes were randomly assigned to the atmospheric (~20%) or low (~5%) oxygen concentration groups on the retrieval day (day 0). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No individuals were homozygous for SLC4A1Delta27.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RESULTS The total postoperative infection rate after hysterectomy was 25.3% (43/170). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The survey asked about self-reported health, source of health information, number of serves of fruit, vegetables, unhealthy food, and sugary drink consumed per day, and frequency of moderate- and vigorous-intensity physical activity per week. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Students who received individualized reading instruction in all three grades showed the strongest reading skills by the end of third grade compared with those who received fewer years of such instruction. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with moderate to severe traumatic brain injury. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ProTECT III was conducted at 49 level I trauma centers in the United States. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Background: Breast cancer is the most frequently diagnosed cancer among women in Turkey and worldwide,\\nand is ranked as the second-leading cause of death in women after lung cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Once technical issues were resolved, screening was fast and well tolerated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study aimed to determine the psychopathological characteristics of transsexuals based on a large sample of French individuals and to identify whether these characteristics differed according to the individual's sociodemographic or clinical characteristics.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "There was no significant difference in bone mineral density (z score -0.31 v -0.77), serum calcium (2.30 v 2.26 mmol/l), 25-hydroxyvitamin D (19.7 v 23.7 nmol/l), parathyroid hormone (2.6 v 3.1 pmol/l), or dietary calcium intake (1021.0 v 1033.0 mg/day) in patients with fracture compared with those without fracture. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Chest radiographs at each time point were scored by an experienced radiologist, blinded to clinical details. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although remifentanil is used widely by many clinicians during general anesthesia, there are recent evidences of opioid-induced hyperalgesia as an adverse effect. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "All three groups of patients showed decreased memory B- and na\u221a\u00d8ve T-cell subsets and decreased B-cell activating factor receptor expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The median age of the patients was 45 yr. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The Limits of Stability (LOS) balance test has received little attention in TBI. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Awareness of hypertension was based on self-report. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We evaluated the clinical characteristics and surgical outcomes of 23 patients with NTM lung diseases who had underwent pulmonary resection. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In mouse models, we found that metastasis of GC-A-nonexpressing tumor cells (i.e., B16 mouse melanoma cells) to the lung was increased in vascular endothelium-specific GC-A knockout mice and decreased in vascular endothelium-specific GC-A transgenic mice compared with control mice. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite these efforts, fruit and vegetable consumption and physical activity did not change from baseline to post-test or differed significantly between intervention and wait list control groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To date, the evidence of a reliable marker of prognosis in these cases remains scarce. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Several advantages of robotic surgery have been reported, but there is no comparative study on postoperative pain between the 2 techniques. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ventral stabilisation yields more advantages than dorsal instrumentation in the long term. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Genome-wide methylation in peripheral blood lymphocytes of 376 healthy women from the prospective EPIC study was investigated using LUminometric Methylation Assay (LUMA). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This excessive interference reflected a blurring of intra- rather than inter-category distinctions as if the acuity of word-object associations had been diminished so that correspondences were easier to recognize at generic than specific levels. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Ankle-brachial indices were abnormal in 78% of patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, there is an urgent need for noninvasive and sensitive biomarkers for prediction of PIR. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "GRS63 was associated with BMD (\u201a\u00e2\u00d63% of the variation explained) but not with BMD change. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study examines prospectively the randomised, long-term, clinical and radiological results of the treatment of spondylitis patients by ventro-dorsal or ventral spine fusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Least absolute shrinkage and selection operator (Lasso) and multiple logistic regression were performed to identify risk factors of disease. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The paired Student t test was used to evaluate differences in diameters of the ostium of the CS in anteroposterior and superoinferior direction. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TNF-induced albuminuria was aggravated in mice with podocyte-specific ABCA1 deficiency and was partially prevented by cholesterol depletion with cyclodextrin. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This event requires BIM CpG methylation/demethylation with 5-azacytidine that leads to detachment of the MeCP2 corepressor complex and reacetylation of the histone tails. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BIM silencing occurs through recruitment of MeCP2 and the SIN3a/histone deacetylase 1/2 (HDAC1/2) corepressor complex. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Traits such as non-acceptance of emotions, lack of clarity and lack of awareness of emotions were related to increased social anxiety; while acting with awareness, non-reactivity, and better ability to describe emotions was related to decreased social anxiety. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The data demonstrate that, along with peripheral vascular occlusive disease, accelerated vascular stiffening is an early and pervasive mechanism of vascular disease in Hutchinson-Gilford progeria syndrome. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Based on their reported frequencies and effect sizes (OR\u201a\u00e2\u202225), we had sufficient statistical power to detect the large majority (80%) of genuine associations at these loci. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Poor compliance for follow-up with formal vision examination limited our ability to confirm these abnormalities. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, all factors examined were associated with at least one QoL domain. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although it is associated with a relatively high complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Health promotion in transport industry workplaces should be an important topic for future research.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study aims to examine the relationship between beliefs about medicines and self-medication with analgesics in dental pain management in Malaysia.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 3 (5.7%) cases, conversion was required. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Only 4.7% (2674 of 57\\u2009170) received HCV screening, with strongest predictors being nonpsychiatric health care utilization and comorbid substance abuse.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study showed the association between stroke and sleep habits in the southern Chinese population and might help in better detecting important sleep-related factors for stroke risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conducted a pilot randomized controlled trial to determine the feasibility and acceptability of a patient navigation intervention. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P\\xa0<\\xa00.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We sought to assess the safety and immunological changes of using a biologically standardized and modified Parietaria judaica pollen extract in accelerated schedules. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for confounders. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We set the fraction of inspired oxygen (FiO2) at 0.30. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "From 127 whole-genome-sequenced isolates, we reconstructed an evolutionary framework of E.\\xa0coli ST410 which portrays the antimicrobial-resistant clades B2/H24R, B3/H24Rx, and B4/H24RxC. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The overall adjusted odds ratio for BP control in the intervention versus usual care group was 3.64 (P\\xa0<\\xa0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sixty consecutive patients undergoing elective open-heart surgery were prospectively enrolled in a study to compare the efficacy of 3 different antifibrinolytic drugs to reduce postoperative bleeding and to reduce homologous blood requirements in combination with blood-saving techniques and restrictive indications for blood transfusion. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Background and purpose - Criticism of the lateral approach (LA) for hip arthroplasty is mainly based on the risk of poor patient-reported outcomes compared to the posterior approach (PA). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These results suggest that the LOS test is an informative tool that should be included in any objective balance evaluations that screen TBI patients with balance complaints.", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, these participants had weaker beliefs in General-Harm (12.00 vs. 10.29, p = 0.006) and General-Overuse (11.38 vs. 10.31, p = 0.032) than those not practising self-medication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "As primary endpoint we investigated the incidence of CIN (increase of serum creatinine \u201a\u00e2\u20220.5\u201a\u00c4\u00e4mg/dL and/or \u201a\u00e2\u202225% within 48\u201a\u00c4\u00e4h of CM).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Although the AD-associated genetic variants appear to have small effects on early cognitive change, replication will be required to establish whether there is a discernible influence on cognitive status in midlife. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "RTX induced initial B cell depletion (<5 cells/\u0152\u00baL) in all patients but re-population was observed in 3 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Possible vision abnormalities were found in 11 of the 137 children (8%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Significant increases in allergen-specific IgG4 and IgG against P. judaica extract and rPar j 2 and significant decrease of specific IgE against Par j 2 were observed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of a total of 115 registered patients having solitary hepatocellular carcinoma (HCC) 2 to 5 cm in diameter, 18 (15.7%) were excluded after randomization. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "CD133+ CD44+ CD54+ cellular subpopulation of CTCs has a prognostic value in CRC patients with liver metastasis, especially in the survival of CRC patients with liver metastasis who did not undergo surgical treatment for metastasis.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Over 63% consumed at least one serve of unhealthy foods per day, and 65% drank at least one can of sugary drink per day. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The original GWAS melanoma study included 15 990 cases and 26 409 controls, representing the largest international meta-analysis of melanoma susceptibility. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite this, there is a paucity of data about Australian truck drivers' diet and physical activity behaviors.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Results: Dental arch measurements, including inter-canine and inter-molar distance, were found to be significantly greater in males than females (p less than\\xa00.05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "EIT-guided PEEP titration led to a more dorsal shift of ventilation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Consistent with other international studies, participants living in neighborhoods with a mix of land uses and a transit stop within a 10-minute walk from home were more likely to use active commuting (both p < 0.01). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pain treatment increased progressively in complexity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Unipolar major depression is often a chronic disease that may require lifelong prophylaxis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants were classified according to the socioeconomic status of their households, defined by the Oxford Poverty and Human Development Initiative's multidimensional poverty index (MPI).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "ANP is known to bind specifically to NPR1 [also called guanylyl cyclase-A (GC-A) receptor]. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "BIM is a proapoptotic member of the Bcl-2 family. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here we demonstrate that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "According to the interval between hysterectomy and cervical conization, patients were classified into 1-2-week, 4-5-week, and 6-week groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Of these patients, 14 had benign masses and 7 had malignant tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "However, only one obesity association was replicated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hand-held, portable, instrument-based vision screening devices can be used in children as young as 6 months of age.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study was a cross-sectional, non-randomized study in public health. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The diameter of the CS ostium in the superoinferior direction (1.13\\xa0\u00ac\u00b1\\xa00.26\\xa0cm) was larger than in the anteroposterior direction (0.82\\xa0\u00ac\u00b1\\xa00.19\\xa0cm) (P\\xa0<\\xa00.05). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To begin development of methods that allow this, we used videofluorography to record the deglutition behaviors of 22 Fisher 344/Brown Norway rats in young adult (9 months old), old (32 months old), and parkinsonian (unilateral lesion to the medial forebrain bundle) groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Materials and Methods In this prospective study, pregnant women were recruited and their healthy full-term newborns underwent a brain MRI including diffusion tensor imaging at approximately 2 weeks of age. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The purpose of this study was to assess social anxiety, and identify how social support, emotion regulation and mindfulness uniquely contribute to social anxiety among adolescents in Birgunj, Nepal. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This strategy provided baseline measures of participant stature, s.c. body fat, and humoral and cell-mediated immune activity as well as subsample longitudinal measures of linear growth (1 wk, 3 mo, 20 mo) and acute inflammation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These dissociations between verbal and non-verbal markers of object knowledge indicate that the reduced neural mass at peak atrophy sites of the left temporal tip, accounting for half or more of the presumed premorbid volume, was unlikely to have contained domain-independent semantic representations of the type that would be expected in a strictly amodal hub. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The ARR is associated with chronic kidney disease (CKD), renal artery stenosis, renin adenoma. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We expected that prayer would be related to pain tolerance in reducing the impact of the pain on patient's daily life, but not necessarily to pain severity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Naming errors were attributed to pure retrieval failure if the object could not be named even when the denoting word was understood, the object recognized and the two accurately matched. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In comparison, only 38 melanoma-related genes were identified in the original meta-analysis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The etiology of primary antibody deficiencies is largely unknown. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "After 1:1 propensity score matching, the final analysis included 142 patients each in the LPN and RAPN groups. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants practising self-medication for dental pain reported more positive beliefs in General-Necessity (13.04 vs. 9.98, p = 0.001) than those not practising self-medication. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A cross-sectional questionnaire design was adopted in order to measure demographics, prayer, pain outcomes (i.e., pain severity and pain tolerance), and cognitive positive re-appraisal. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "No other associations with HLA genotype were identified. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Between January 1987 and December 1998, we treated 867 patients suffering from primary solid malignant tumours. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Similar trend was shown among both boys and girls for their father's education level. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Our aim was to evaluate appearance of unrelated atypical serum immunofixation patterns (ASIPs) as a marker of prognosis in MM patients submitted to ASCT. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Methods: Patients referred for a stress-rest 99mTc-sestamibi protocol and positioned in the biker position, with the chest leaning forward on the D.SPECT camera-head at 35\u00ac\u221e from vertical, had an additional resting D.SPECT recording in the supine position (n = 40) or in the sitting position with the back rearward at 30\u00ac\u221e from vertical (n = 40). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pulmonary dysfunction is a significant contributor to morbidity and mortality in the pediatric burned population. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Continuous infusion of remifentanil during general anesthesia can cause higher intensity of postoperative pain and more frequent itching than general anesthesia without remifentanil infusion immediately after thyroidectomy. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Different environmental attributes were associated with active commuting, suggesting that these relationships are complex and may distinctly differ from those in high-income countries. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Hemoconcentration and reinfusion of blood drained from the operative field and the extracorporeal circuit after operation were used in all patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Policies and investments to promote active commuting remain under-developed in LMICs like India, which grapples with traffic congestion, lack of activity-supportive infrastructure, poor enforcement of traffic rules and regulations, air pollution, and overcrowding. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "One hundred fifty patients underwent 151 limb-salvage surgeries for bone cancer of the extremities in this series. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The purpose of our study was to assess quality of life (QoL) among Georgian HIV-infected individuals and to examine factors associated with QoL. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 3 polymorphisms of AKT1 (rs1130214, rs2494732, rs3803300), the GT/TT genotype of rs1130214 in cases and controls had a significant frequency difference (P\\u200a=\\u200a.04) and was 1.71 times risk developing CHD, compared with AA (OR\\u200a=\\u200a1.71, 95%CI\\u200a=\\u200a1.02-2.86), and T allele had 1.63 times risk for carriers (OR\\u200a=\\u200a1.63, 95%CI\\u200a=\\u200a1.05-2.54). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These correlations were largely independent of several demographic parameters as well as family environment. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These infants were tested at approximately 2 years of age with the Bayley Scales of Infant Development (BSID). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We describe a project that followed all of these recommended strategies, but did not achieve desired outcomes. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eleven of 69 prospectively enrolled primary progressive aphasics were selected for this study because of peak atrophy sites located predominantly or exclusively within the anterior left temporal lobe. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This represented 3% to 48% of all AML searches (median 20%) per center, totaling 3 to 172 patients (median 22) per center. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Aldosterone-to-renin ratio (ARR) is a screening test for primary aldosteronism, but it was impacted by a bunch of clinical covariates. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Donor KIR genotype was reported at a median of 14 days after request (\u201a\u00e2\u00a726 days for 76% of searches). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings emphasise several issues of importance when conducting rare GSV association, including the need for careful cohort selection and replication strategy, accurate GSV identification, and appropriate correction for multiple testing and/or control of false discovery rate. ", "output": "This is a strong advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This highlights the importance of educational interventions and ARV treatment in HIV patients. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative nausea was less frequent in group R (31.4%) than in group N (53.5%) (P\\u200a<\\u200a0.001). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 17 (32.1%) patients, postoperative complications occurred, with 7 of them (13.2%) being serious (Clavien-Dindo 3-5). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Pearson Product Moment Correlations demonstrated significant (p\\u2009<\\u20090.001) associations between better neuropsychological performance and higher GOSE scores. ', \"Similar to the ProTECT III trial's results of the primary outcome, the secondary outcomes do not provide evidence of a neuroprotective effect of progesterone.\"]", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, 60 SNPs were associated (P\\xa0<\\xa00.05) with risk of high grade breast cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, machines and humans use a plan-until-habit scheme that simulates the environment up to a limited depth and then exploits habitual values as proxies for consequences that may arise in the future. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The aim of the current study was to examine the influence of methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation and angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) variations on the risk of osteoarthritis. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The low oxygen group had a significantly higher blastocyst formation rate than the atmospheric oxygen group (64.5% vs. 52.9%). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The MTHFR C677T mutation was analyzed by polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP) methods. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The most prevalent dental arch forms were narrow tapered (50.3%) and narrow ovoid (34.2%), respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To determine the dental arch dimensions and arch forms in a sample of Saudi orthodontic patients, to investigate the prevalence of Bolton anterior and overall tooth size discrepancies, and to compare the effect of gender on the measured parameters.\\xa0", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This result provides a potentially useful knowledge of postoperative pain characteristics in RAPN and LPN.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "While homozygosity for SLC4A1Delta27 appears to be nonviable, the GYPCDeltaex3 allele is not lethal when combined with SLC4A1Delta27. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell lymphoma (ALCL) cell lines and in lymph node biopsies from NPM/ALK+ ALCL patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Prevalence increased with age (mass), and apparent seasonality was due to a higher proportion of older animals in spring. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants self-reported their usual mode of commute to work, with responses recoded into three categories: (1) multi-modal or active commuting (walking and bicycling; n = 56); (2) public transit (n = 52); and (3) private transport (n = 111). Associations between environmental characteristics and likelihood of active commuting and public transit use were modeled using logistic regression with private transport (driving alone or carpool) as the reference category, adjusting for age, gender, and household car ownership. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conducted a cross-sectional analysis of the third wave follow-up of the Andhra Pradesh children and parents study (APCAPS) (n\\u202f=\\u202f5764, median age 28.8\\u202fyears) in south India. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The body condition of individuals with lesions declined at the time when the lesion was first recorded, when compared to individuals without lesions, suggesting there may be an acute phase of infection during its advanced stage. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In this observational cohort study, we report patient outcomes with RTX in GPA patients with pulmonary nodules who failed to achieve remission following conventional immunosuppression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The liver metastatic CRC patients with high expression of CD133+ CD54+ (P\\xa0<\\xa00.001), CD133- CD54+ (P\\xa0=\\xa00.004), and CD133+ CD44+ CD54+ (P\\xa0=\\xa00.003) cellular subpopulations of CTCs had a worse survival than those patients with low expression. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data from the Sixth Korea Youth Risk Behavior Web-based Survey (KYRBWS-VI), a cross-sectional study among 74,980 students in 800 middle schools and high schools with a response rate of 97.7%, were analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Environmental attributes around participants' homes were assessed using the Neighborhood Environment Walkability Scale for India (NEWS-India).", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "To test this hypothesis, 24 men and 24 women age 58 \u00ac\u00b1 2.4 yr were pretreated with leuprolide and either sex steroid (E2 in women, T in men) or placebo addback. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, combining two pairs of genes improved sensitivity without compromising specificity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We sent a questionnaire to all the crematoria in the UK enquiring about the frequency, consequences and prevention of pacemaker explosions. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Failure was defined as definite aseptic loosening, and the final survivorship at 8 years was 99.3% for the SL-stem, and 99.1% for the CSF-threaded cup. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Homologous blood requirements were not significantly different among the groups; postoperative hematologic values and coagulation times were also comparable. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Contrary to findings in high-income countries, the odds of active commuting were reduced with improved safety from crime (aOR =0.2, p = 0.003), aesthetics (aOR =0.2, p = 0.05), and street connectivity (aOR =0.2, p = 0.003). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data acquisition was performed using electrocardiography-triggered, navigator-gated, inversion-recovery prepared, segmented gradient-echo sequence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study aims to investigate relationship between ARR and primary aldosteronism in CKD patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We hypothesize that the administration of oxandrolone will improve pulmonary function in burned pediatric subjects. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Six potential factors were estimated to be associated with increased risk of hypertension including age, ethnicity, marital status, body mass index (BMI), waistline circumference, and comorbidity. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In conclusion, comparative analysis of the expression of two genes may be a simple and effective classifier for prediction of prostate cancer progression. ", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We retrospectively analysed data from 65 patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Therefore, intraoperative antifibrinolysis may not be indicated in routine cardiac surgery when other blood-saving techniques are adopted.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Sixty-one single nucleotide polymorphisms (SNPs) from 40 genes were associated (P\\xa0<\\xa00.05) with risk of breast cancer in a log-additive model. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These data provide evidence that serum oestradiol concentrations in post-menopausal women may have a substantial effect on breast cancer risk.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "This study supports the hypothesis that subsensory vibratory noise applied to the soles of the feet can reduce gait variability in elderly participants. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Seminal plasma HIV-1 RNA level is an important determinant of the risk of HIV-1 sexual transmission. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We conclude that, in our cohort, the immunophenotypic landscape of primary antibody deficiencies comprises a spectrum, in which some alterations are shared between all primary antibody deficiencies whereas others are only associated with common variable immunodeficiency. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants completed a structured questionnaire to identify sleep habits and other stroke risk factors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eighteen elderly recurrent fallers and 18 elderly non-fallers were recruited from the MOBILIZE Boston Study (MBS), a population-based cohort study investigating novel risk factors for falls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Furthermore, asymptomatic relatives showed decreased levels of CD4+ recent thymic emigrants and increased central memory T cells. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We show that BIM is epigenetically silenced in cell lines and lymph node specimens and that treatment with the deacetylase inhibitor trichostatin A restores the histone acetylation, strongly upregulates BIM expression, and induces cell death. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A comprehensive early childhood vision screening program in Hawai'i utilizing automated hand-held photoscreeners may have public health value.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The immunogenicity of HBV vaccine and the effectiveness of the universal immunization strategy have been widely demonstrated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Multivariate logistic regression and linear models were used to investigate the association between reproductive risk factors and genome wide and CpG-specific DNA methylation, respectively. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "An optimized risk score model was used to assess the risk and determine the predictive power of risk factors on hypertension.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Patients completing continuation treatment without relapse enter 52 weeks of doubleblind maintenance treatment, where those treated with WS 5570 are re-randomized to 3 x 300 mg/day WS 5570 or placebo. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Further natural history studies are likely to provide information to help improve the content of psychological treatments for cannabis use. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In 535 searches, 2080 donors were requested for KIR genotyping (mean 4.3 per search); and a median of 1.8 (range, 0 to 4.5) per search were KIR typed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "TB was monitored for 2 years in wild field voles in Kielder Forest, UK. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In addition, the prevalence of hypertension (SBP \u201a\u00e2\u2022 130 or DBP \u201a\u00e2\u2022 80 mm Hg) was also estimated according to the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) High Blood Pressure Guideline. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "A total of 108 individuals provided a valid MMPI-2 between January 2007 and December 2010. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Plasma from patients and controls was incubated with renal tubular cells (RTCs) and cell death was evaluated. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "These findings may help prioritize patients for whom the intervention is most effective.", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "The study was to investigate the effects of oxygen concentration at different levels for culturing pre-compaction embryos on human embryo development competence. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Despite progressing slowly, it causes severe clinical pathology and overt symptoms in its rodent host. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Lower density of fruit/vegetable vendors, and higher density of highly processed/take-away food vendors were associated with adverse cardiovascular risk profiles. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Around 2014, the clade B4/H24RxC acquired a second carbapenemase gene, blaNDM-5, on a conserved IncFII plasmid. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "DUP is a modifiable factor that if reduced can improve patient outcome and treatment response. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Data about other variables of interest were obtained from medical records. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "In the present study, we investigated national epidemiology of ST410 E.\\xa0coli isolates from Danish patients. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We enrolled 11 CRS Type 5 patients from ICU and 16 healthy controls. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Postoperative complications occurred in eight patients (35%), including postoperative pneumonia (n=3) and late bronchopleural fistula (n=2). ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "MATERIAL AND METHODS Fifty-three (21 female/32 male) patients who underwent elective laparoscopic total gastrectomy due to cancer were prospectively analyzed. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Surgical removal of solid tumors is performed as an initial attempt to cure patients; however, surgery is often accompanied with trauma, which can promote early recurrence by provoking detachment of tumor cells into the blood stream or inducing systemic inflammation or both. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "We performed cardiovascular assessments at a single clinical site on the largest prospectively studied cohort to date. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Specifically, disregulation and somatic mutation of mitotic regulators has been observed in human cancers, and overexpression of mitotic regulators is common in aggressive and late stage tumors. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Eating competence is associated with a healthy diet and could, thus, in the long term, support the prevention of type 2 diabetes.", "output": "This is a weak advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Gait variability reductions with noise were similar between the elderly recurrent fallers and elderly non-fallers. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Group 1 consisted of 12 patients who (after ventral removal of the focus of infection and autologous bone grafting) were treated by dorsal instrumentation. ", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Participants were evaluated for their self-medication practices via 4 items", "output": "This is no advice"}, {"instruction": "Question: is this a 2) strong advice, 1) weak advice 0) no advice?", "input": "Using a split litter design, we generated stressed mice (STR) and within litter controls (LMC) along with age-matched, untreated animals (AMC), to serve as across litter controls. ", "output": "This is no advice"}]