mdpi-ai/citelens huggingface dataset:
Survival Outcomes and Prognostic Analysis Following Greater Cytoreductive Radiotherapy in Patients With Metastatic Prostate Cancer
Field: ONCOLOGY

Purpose: To assess the survival outcomes of patients with metastatic prostate cancer (mPCa) who undergo greater cytoreductive radiotherapy in a real-world clinical practice and determine their prognostic factors. Methods: We performed a retrospective study of 160 patients with mPCa who underwent cytoreductive radiotherapy between 2009 and 2018 at a single institution. The degree of the cytoreductive burden was calculated for each patient. Overall survival (OS) was calculated from the date of detection of metastases. Variables associated with prostate-specific antigen (PSA) response and OS were evaluated via univariate and multivariate analyses. Results: The median follow-up period was 47.2 months. The median OS was 42.3 months with a 5-year OS rate of 37.9%. The PSA levels of 90 patients (56.7%) decline by > 50% after radiotherapy. The 5-year OS rates of patients who underwent total, major, and minor cytoreductive radiotherapy were 53.4, 38.2, 17.6%, respectively; the corresponding median OS intervals were 62.5, 41.0, and 24.4 months, respectively (P < 0.001). A greater extent of cytoreduction (P < 0.05), lower PSA at radiotherapy initiation [hazard ratio 0.51, 95% confidence interval [CI] 0.33–0.78; P = 0.002] and better PSA response [hazard ratio 0.47, 95% CI 0.30–0.72; P < 0.001] were independent factors associated with superior OS. A high metastatic burden (as defined in the CHAARTED trial) was the only independent predictor of a poorer PSA response (odds ratio 0.36, 95% CI 0.19–0.69; P = 0.002). Grade 2 late gastrointestinal and genitourinary toxicities were observed in 3 and 2 patients, respectively, and only 1 patient had grade 3 late gastrointestinal toxicity. Conclusion: Cytoreductive radiotherapy is effective and safe in select patients with mPCa. Greater cytoreduction, together with lower PSA at radiotherapy initiation and improved PSA response are favorable prognostic factors. Further studies are needed to confirm our findings.
OER4Schools: Outcomes of a Sustained Professional Development Intervention in Sub-Saharan Africa
Field: EDUCATION

Sustaining educational initiatives beyond short-term pilot projects is highly challenging in low-income countries. We describe the outcomes and implications of our iterative Design-Based Implementation Research conducted in Zambia. This focused on a unique, school-based, peer-facilitated professional learning programme for primary teachers: OER4Schools integrates interactive pedagogy, open digital educational resources and mobile learning. Teacher interviews carried out 18 months after a year-long intervention showed that the programme became self-sustaining; earlier participants reported further development of their interactive teaching strategies and awareness of pupil progress; recent joiners developed similarly. Roles of teachers and pupils changed and a new classroom culture emerged. The study identifies the key mechanisms involved in sustainability, including culturally sensitive and participatory development and implementation, semi-structured multimedia materials, and supportive organisational structures for sustained professional learning. Our findings are hence framed by sociocultural influences as well as the wider policy context.
Inhibitory Effect of a Microecological Preparation on Azoxymethane/Dextran Sodium Sulfate-Induced Inflammatory Colorectal Cancer in Mice
Field: ONCOLOGY

This study aims to investigate the antitumor effect and the possible mechanism of a microecological preparation (JK5G) in mice. The mice treated with AOM/DSS were then randomly divided into the two model groups and the JK5G group, and the blank control group was included. Fecal samples were used for liquid chromatography–mass spectrometry and 16S rRNA gene sequencing analyses to reveal metabolic perturbations and gut flora disorders to demonstrate the effects of JK5G. Compared with the mice in the control group, the weight and food intake of mice after JK5G treatment were both upregulated. Moreover, JK5G could inhibit the growth of colon tumors and prolong the survival rate of mice, as well as inhibit the levels of cytokines in serum. The proportions of lymphocytes, T cells, CD3+CD4+ T cells, and CD3+CD8+ T cells in the spleen of the JK5G mice were all significantly increased compared to those in the control group (p < 0.05). Similarly, compared with the model group, the proportions of lymphocytes, B cells, T cells, natural killer T cells, CD3+CD4+ T cells, and CD3+CD8+ T cells in the intestinal tumors of the JK5G mice were significantly increased (p < 0.05). Furthermore, 16S rRNA high-throughput sequencing data revealed that Alloprevotella in the JK5G group was significantly upregulated, and Ruminiclostridium, Prevotellaceae_UCG_001, and Acetitomaculum were significantly downregulated. Fecal and serum metabolite analysis detected 939 metabolites, such as sildenafil and pyridoxamine, as well as 20 metabolites, including N-Palmitoyl tyrosine and dihydroergotamine, which were differentially expressed between the JK5G and model groups. Integrated analysis of 16s rRNA and metabolomics data showed that there were 19 functional relationship pairs, including 8 altered microbiota, such as Ruminiclostridium and Prevotellaceae_UCG_001, and 16 disturbed metabolites between the JK5G and model groups. This study revealed that JK5G treatment was involved in the growth of colorectal cancer, which may be associated with the role of JK5G in improving the nutritional status of mice and regulating the tumor microenvironment by regulating the changes of intestinal microbiota and metabolite bands on different pathways.
Prejudice, Does It Exist or Not? Consumer Price Discrimination in Minority Entrepreneurship
Field: PSYCHOLOGY

Many prior studies on minority entrepreneurship have found that some consumers display a strong bias against products from minority ventures. Not surprisingly, discrimination against products sold by minority-owned businesses increases the failure rate for such ventures. This paper seeks to verify the extent of consumer discrimination for minority products, and investigates whether it varies among different products. Building on insights from the theory of consumer discrimination, we conducted a comparative behavior experiment on 155 subjects for the expected pricing of two new products (common products and products with ethnic characteristics). Consistent with prior literature, we found that potential consumers held a bias against common products from minority ventures and offered a lower price. However, the theory of consumer discrimination could not be applied to the products with ethnic characteristics. Instead, potential consumers viewed ethnic characteristics products from minority ventures as being high quality and offered higher prices. This finding complements the theory of consumer discrimination and provides useful knowledge for minority entrepreneurs: minority entrepreneurs can employ price discrimination to strengthen the ethnic brand’s impression by integrating ethnic cultural features into new products.
Gender gaps in the performance of Norwegian biology students: the roles of test anxiety and science confidence
Field: EDUCATION

Background: Understanding student motivational factors such as test anxiety and science confidence is important for increasing retention in science, technology, engineering, and math (STEM), especially for underrepresented students, such as women. We investigated motivational metrics in over 400 introductory biology students in Norway, a country lauded for its gender equality. Specifically, we measured test anxiety and science confidence and combined students’ survey responses with their performance in the class. Results: We found that female students expressed more test anxiety than did their male counterparts, and the anxiety they experienced negatively predicted their performance in class. By contrast, the anxiety male students experienced did not predict their performance. Conversely, men had higher confidence than women, and confidence interacted with gender, so that the difference between its impact on men’s and women’s performance was marginally significant. Conclusions: Our findings have implications for STEM instructors, in Norway and beyond: specifically, to counter gender-based performance gaps in STEM courses, minimize the effects of test anxiety.
Deep Active Inference and Scene Construction
Field: AI

Adaptive agents must act in intrinsically uncertain environments with complex latent structure. Here, we elaborate a model of visual foraging—in a hierarchical context—wherein agents infer a higher-order visual pattern (a “scene”) by sequentially sampling ambiguous cues. Inspired by previous models of scene construction—that cast perception and action as consequences of approximate Bayesian inference—we use active inference to simulate decisions of agents categorizing a scene in a hierarchically-structured setting. Under active inference, agents develop probabilistic beliefs about their environment, while actively sampling it to maximize the evidence for their internal generative model. This approximate evidence maximization (i.e., self-evidencing) comprises drives to both maximize rewards and resolve uncertainty about hidden states. This is realized via minimization of a free energy functional of posterior beliefs about both the world as well as the actions used to sample or perturb it, corresponding to perception and action, respectively. We show that active inference, in the context of hierarchical scene construction, gives rise to many empirical evidence accumulation phenomena, such as noise-sensitive reaction times and epistemic saccades. We explain these behaviors in terms of the principled drives that constitute the expected free energy, the key quantity for evaluating policies under active inference. In addition, we report novel behaviors exhibited by these active inference agents that furnish new predictions for research on evidence accumulation and perceptual decision-making. We discuss the implications of this hierarchical active inference scheme for tasks that require planned sequences of information-gathering actions to infer compositional latent structure (such as visual scene construction and sentence comprehension). This work sets the stage for future experiments to investigate active inference in relation to other formulations of evidence accumulation (e.g., drift-diffusion models) in tasks that require planning in uncertain environments with higher-order structure.
Experimental and clinical studies on radiation and curcumin in human glioma
Field: ONCOLOGY

Purpose: There is progressing evidence for the anti-cancer potential of the natural compound and dietary spice curcumin. Curcumin has been ascribed to be cytotoxic for various tumour cell types, to inhibit cell proliferation and to interfere with the cellular oxidant status. The compound has been notified as a therapeutic agent with radiosensitizing potential in brain tumour therapy. We considered the rationale to combine curcumin with radiation in the treatment of human glioblastoma multiforme (GBM). Method: Determination of clonogenic cell survival following exposure of U251 human glioma cells to single dose (1–6 Gy) and fractionated irradiation (5 daily fractions of 2 Gy) without and with curcumin. Additional literature search focused on the interaction between curcumin and radiotherapy in experimental and clinical studies on human glioma. Results: No interaction was found on the survival of U251 human glioma cells after irradiation in combination with curcumin at clinically achievable concentrations. Experimental in vitro and in vivo data together with clinical bioavailability data from the literature do not give evidence for a radiosensitizing effect of curcumin. Reported GBM intratumoural curcumin concentrations are too low to either exert an own cytotoxic effect or to synergistically interact with radiation. Novel approaches are being explored to increase the bioavailability of curcumin and to facilitate transport over the blood–brain barrier, aimed to reach therapeutic curcumin levels at the tumour site. Conclusion: There is neither a biological nor clinical rationale for using curcumin as radiosensitizer in the therapy of GBM patients.
Unbiased Decisions Among Women’s Basketball Referees
Field: PSYCHOLOGY

Decisions often reflect implicit biases. Ethnic, racial, and gender traits are associated with stereotypes that may influence the decision-making process. Previous research shows that referees’ decisions in men’s professional sports are often biased in favor of racial and nationalistic in-groups. This study examined if similar biases exist in women’s professional sports. Additionally, this study analyzed the potential influence of the gender composition of referee teams on rapid decisions. We gathered data on referee foul calls in women’s professional basketball in Spain, 2014–2019 and defined important decisions (fifth fouls) and stressful situations (one-possession matches). The main finding is that out-groups based on racial (i.e., Black players) and nationalistic (i.e., foreign players) criteria did not differ in number of foul calls received. In stressful situations, foreign players actually received fewer fouls than Spanish players. Similarly, there was no evidence of bias due to the gender composition of referee teams: foul calls did not differ between all-male and mixed teams. Implications for race and nationality as dynamic social constructs within ethnocentric and social identity theories are discussed.
Variation in which key motivational and academic resources relate to academic performance disparities across introductory college courses
Field: EDUCATION

Background: Differences in post-secondary academic outcomes along dimensions of gender, race/ethnicity, and socioeconomic status are a major concern. Few studies have considered differences in patterns of academic outcomes and underlying mechanisms driving disparities across different STEM disciplines. Using data from about 4000 undergraduates in introductory STEM courses at a large, urban university in the eastern United States, this study examines how differences in course grades by gender, race/ethnicity, and parent education vary in introductory chemistry, physics, and psychology courses. In addition, structural equation modeling techniques examine whether academic resources and discipline-specific motivational attitudes are important mediators of demographic differences in course grades.Results: This study finds that women have higher course grades than men on average in psychology, and men have marginally higher grades than women in physics. In addition, students whose race/ethnicity is represented or overrepresented in these courses (students who are White and or Asian) have higher course grades in chemistry and physics and marginally higher grades in psychology on average compared with underrepresented students (who are Black, Latinx, Native American, Pacific Islander, and or other racial/ethnic backgrounds). Further, first-generation college students have lower course grades in physics and psychology on average than students with a college-educated parent. The largest average differences in course performance are about half a full letter grade (e.g., the difference between a B and an A−). This study also finds that some demographic differences in physics and chemistry performance are linked to math resources whereas some disparities in psychology are more related to verbal resources. In addition, the results suggest discipline-specific self-efficacy is a motivational attitude associated with course performance in chemistry, physics, and psychology, while discipline-specific interest is only relevant in chemistry.Conclusions: Overall, the findings emphasize that there are demographic differences in post-secondary course performance on average, and academic resources and motivational attitudes help explain these differences. Importantly, the specific findings differ across chemistry, physics, and psychology. Understanding these pathways and how they are similar and different across disciplines within STEM is crucial for developing interventions aimed at attenuating disparities in post-secondary academic outcomes.
Psychological Pathways Linking Public Trust During the Coronavirus Pandemic to Mental and Physical Well-being
Field: PSYCHOLOGY

The well-being of the public during the 2019 coronavirus (COVID-19) pandemic is deeply rooted in institutional trust in the government’s risk communication effort. The objective of this study was to examine the psychological pathway through which public trust in the government is associated with mental and physical well-being. We collected cross-sectional data from 501 participants aged ≥18 years using an online panel. Public trust in the government was assessed as our exposure variable. We screened for psychological distress by combining the Patient Health Questionnaire and the General Anxiety Disorder scale. Physical well-being was examined using self-rated health. We further assessed the roles of risk perceptions. The author conducted a one-way analysis of variance (ANOVA), Pearson’s correlations, multivariable regressions, and mediation analyses (using the Preachers and Hayes’ approach). Participants were 55.29% female, 67.86% Caucasian/white with a mean age of 32.44 ± 11.94 years. Public trust in the government regarding COVID-19 was negatively correlated with psychological distress (r = −0.20; p < 0.001) and positively associated with physical well-being (r = 0.13; p < 0.001). After adjusting for sociodemographic and socioeconomic factors, public trust remained negatively associated with psychological distress (β = −0.19; 95% confidence intervals, [CI] −0.30, −0.09) and positively associated with physical well-being (β = 0.26; 95% CI [0.16, −0.37]). Perceived self-efficacy to practice COVID-19 protective behavior partially mediated the relationship between public trust and psychological distress (13.07%); and physical well-being (28.02%). Perceived self-efficacy to protect self against COVID-19 infection can serve as a psychological pathway through which public trust may be associated with mental and physical health.
AI for Improving Children’s Health: A Community Case Study
Field: AI

The Indian health care system lacks the infrastructure to meet the health care demands of the country. Physician and nurse availability is 30 and 50% below WHO recommendations, respectively, and has led to a steep imbalance between the demand for health care and the infrastructure available to support it. Among other concerns, India still struggles with challenges like undernutrition, with 38% of children under the age of five being underweight. Despite these challenges, technological advancements, mobile phone ubiquity and rising patient awareness offers a huge opportunity for artificial intelligence to enable efficient healthcare delivery, by improved targeting of constrained resources. The Saathealth mobile app provides low-middle income parents of young children nflwith interactive children’s health, nutrition and development content in the form of an entertaining video series, a gamified quiz journey and targeted notifications. The app iteratively evolves the user journey based on dynamic data and predictive algorithms, empowering a shift from reactive to proactive care. Saathealth users have registered over 500,000 sessions and over 200 million seconds on-app engagement over a year, comparing favorably with engagement on other digital health interventions in underserved communities. We have used valuable app analytics data and insights from our 45,000 users to build scalable, predictive models that were validated for specific use cases. Using the Random Forest model with heterogeneous data allowed us to predict user churn with a 93% accuracy. Predicting user lifetimes on the mobile app for preliminary insights gave us an RMSE of 25.09 days and an R2 value of 0.91, reflecting closely correlated predictions. These predictive algorithms allow us to incentivize users with optimized offers and omni-channel nudges, to increase engagement with content as well as other targeted online and offline behaviors. The algorithms also optimize the effectiveness of our intervention by augmenting personalized experiences and directing limited health resources toward populations that are most resistant to digital first interventions. These and similar AI powered algorithms will allow us to lengthen and deepen the lifetime relationship with our health consumers, making more of them effective, proactive participants in improving children’s health, nutrition and early cognitive development.
University Students’ Motives-for-Physical-Activity Profiles: Why They Practise and What They Get in Terms of Psychological Need Satisfaction
Field: PSYCHOLOGY

Physical activity (PA) is an important habit for overall health and quality of life, but it tends to recede as young adults transition from high school into university. The present study sought to understand, in the case of university students that still practice PA, their motives for PA and their relationships with psychological need satisfaction (PNS) and characteristics of practice regularity (frequency, duration, team, competitive, coach, league, federation, and type of day of the week for PA). Participants were 423 university students who reported to practice PA (203 identified as men, 191 as women, 29 did not report gender), with ages ranging from 18 to 30 years old (M = 19.91, SD = 1.97). Measures assessing motives for PA, PNS, and PA characteristics were completed. Hierarchical, followed by iterative, cluster analysis was used and four naturally occurring groupings of university students were identified based on their motives for PA: one extrinsic-motives cluster (with both extrinsic motives—fitness and appearance—above the mean), one all-motives cluster (with all five motives above the mean), one intrinsic-motives cluster (with all three intrinsic motives—enjoyment, competence, social—above the mean), and one low-motives cluster (with all motives below the mean). Groupings were compared in terms of the characteristics of their practice regularity (frequency, duration, competition, team, coach, league, federation, type of day of the week used for PA) and their levels of PNS (of the needs for autonomy, competence, and relatedness in PA). Significant between-group differences were observed in the duration of single principal PA sessions, minutes per week practicing main PA, total PA minutes per week, and type of day of the week used for PA. The number of days per week devoted to the principal PA and the number of total PAs practiced were similar across all four clusters. With regard to between-group differences in psychological need satisfaction in PA by cluster, these analyses showed the existence of four clearly distinguishable naturally occurring groupings based on motives for PA, which gives researchers and practitioners the possibility to analyze and implement tailored interventions aimed at promoting PA among university students.