DoD Peer Reviewed Alzheimer’s Transforming Research Award
Agency: Dept. of the Army -- USAMRAA
Posted: 2024-03-25 | Closing date: 2024-06-20
Estimated total program funding: 5000000
Expected number of awards: 5
Cost sharing or matching requirement: No

The FY24 PRARP TrRA is intended to support studies that will make transformative and advanced contributions to reduce risk of or prevent the development of AD/ADRD. Risk reduction considering TBI and/or military service is of particular interest to the program. The work should significantly accelerate efforts in AD/ADRD research and demonstrate significant impact toward improving patient care and/or quality of life. To meet the intent of the funding opportunity, applications must robustly address an important problem or a critical barrier to progress in prevention and risk reduction. The proposed research may include, but is not limited to, exploring questions in the following areas: · Identification of risk factors (environmental, genetic, epigenetic, lifestyle, etc.). · Identification and implementation of strategies to reduce AD/ADRD risk and prevent cognitive problems following TBI and/or military service. · Understanding the role of social determinants of health in risk reduction. · Informational (not descriptive) epidemiology to understand environmental and other factors that contribute to development of AD/ADRD. All applications submitted to this funding opportunity must clearly indicate how the project addresses a critical unmet need, explain how the research will be representative of the population it intends to benefit, and demonstrate cultural competence. Culturally competent research factors the cultural background and diversity of the intended beneficiaries of the research outcomes when developing research ideas, conducting research, and implementing the research findings. Cultural competency in research is critical in reducing health disparities and enhancing the quality and impact of research by ensuring inclusivity, understanding, and responsiveness to the needs of diverse populations. Key elements of this award mechanism include: · Research should be robust: The FY24 PRARP TrRA mechanism is geared toward supporting robust, well-designed research projects that provide significant impact on the AD/ADRD field, persons living with dementia, and their families, care-partners/caregivers. Inclusion of collaborative Community partner approaches is strongly encouraged for all projects and is required for all projects involving clinical research. Use of animal models must be fully justified for relevance to human health. · Non-incremental advancement: Research projects should leverage existing knowledge to accelerate ideas, strengthen evidence, and move the field forward. Therefore, preliminary data are required. Projects proposing incremental advances that do not significantly propel the field do not meet the intent of this mechanism. · Feedback to the Community: Applicants are expected to articulate a plan for relaying the results and outcomes of the research supported by this mechanism must be relayed back to the research/Community(ies) to allow for continued knowledge building. · Optimizing research impact through Community collaboration: Research funded by the FY24 PRARP should be responsive to the needs of people living with AD/ADRD. Community collaboration is required for clinical research projects and encouraged for preclinical studies. Establishment and utilization of effective and equitable collaborations and partnerships with members of the AD/ADRD lived experience, family, and care partner communities, which will be referred to as Community(ies) in the remainder of the Funding Opportunity, maximizes the translational and impact potential of the proposed research. Collaborative research approaches feature shared responsibility and ownership for the research project to ensure non-tokenistic involvement of Community members within the research team. Collaborative research approaches such as Community-based participatory research, participatory action research, and integrated knowledge transition generate partnerships between scientific researchers and Community members to create knowledge useable by both sets of stakeholders. Recognizing the strengths of each partner, scientific researchers and Community members must collaborate and contribute their expertise equitably on all aspects of the project, which may include needs assessment, planning, research intervention design, implementation, evaluation, and dissemination. Research results are jointly interpreted, disseminated, fed back to affected communities, and may be translated into interventions or policy. These methods are critically important for Community-level interventions and can also augment the potential impact of a research program on people living with dementia, their families, and/or their care partners. These collaborative relationships are often established through integrating Community members into research teams as co-researchers, advisors, and consultants. Some examples for Community collaborations include: · Lived Experience Consultation: The research team includes at least one project advisor with AD/ADRD experience who will integrate with the research team to provide consultation throughout the planning, implementation, and dissemination of the research project. Lived experience consultants (LECs) may include individuals with AD/ADRD, their family members, care partners, or others as appropriate. · Partnership with a Community-Based Organization: The research team establishes partnerships with at least one Community-based organization that provides consultation throughout the planning, implementation, and dissemination of the research project. Community-based organizations may include advocacy groups, service providers, policymakers, or other formal organizational stakeholders. · Community Advisory Board (CAB) Utilization: A CAB is composed of multiple Community stakeholders and can take many forms, from a board of LECs to a coalition of Community-based organizations or any combination thereof. As with LECs and organizational partners, the CAB provides consultation throughout the planning, implementation, and dissemination of the research project. Career Initiation or Transition (CIT) Partnership Option: The FY24 PRARP encourages applications that include meaningful and productive collaborations between two principal investigators. To promote enhanced research capacity within the AD/ADRD field, the FY24 TrRA includes an option for a CIT Principal Investigator (PI) to partner with an experienced to jointly address a research question. The CIT PI must have nominal, if any, research support in the field and may be either one of the following: · The Career Initiation PI must be an early-career researcher, at least 3 years post their terminal degree but no more than 7 years into their independent position. Both PIs may have similar or disparate expertise, but each PI is expected to bring distinct and complimentary contributions to the application. · The Career Transition PI must be an investigator (at any stage) who is new to the military health, TBI, or AD/ADRD field(s). “New to the field” is defined as having only nominal, if any, publications in the field. The other partnering investigator must have complimentary experience (as evidenced by publications) in military health, TBI, and/or AD/ADRD field(s). The CIT is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for most of the administrative tasks associated with application submission. The other will be identified as a Partnering PI. Either PI can be the CIT PI. Both PIs should contribute significantly to the development of the proposed research project, including the Project Narrative, Statement of Work (SOW), and other required components. Both PIs may have experience in similar or disparate scientific disciplines, but each PI is expected to bring distinct and complimentary contributions to the application. If recommended for funding, each PI will be named to an individual award within the recipient organization(s). For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.