maxwellt/fedgrantsembedded huggingface dataset:
Family Self-Sufficiency Demonstration Development Phase 2 Awards
Agency: Administration for Children and Families - OPRE
Posted: 2024-04-17 | Closing date: 2024-06-18
Electronically submitted applications must be submitted no later than 11:59 pm Eastern Standard Time on the listed application due date.
Estimated total program funding: 1000000
Award ceiling: 200000
Award floor: 100000
Expected number of awards: 5
Cost sharing or matching requirement: No

The Office of Planning, Research, and Evaluation (OPRE) within the Administration for Children and Families (ACF) is soliciting applications for the Family Self-Sufficiency Demonstration Development (FSSDD) Phase 2 Awards (note that all instances of the term “continuation” that appear throughout the NOFO refer to Phase 2 of the program). Entities who were awarded the initial award (HHS-2021-ACF-OPRE-PE-1944) are eligible to apply for this current cooperative agreement.During the initial award, recipients conducted foundational evidence capacity-building activities relevant to their interventions. During this continuation award, recipients will continue building on the progress they made during the initial award. The FSSDD Phase 2 award has two main purposes. The first purpose is to support recipients in building their internal evidence capacity to strengthen evidence-informed program services and improve outcomes for the families they serve. The second purpose is for recipients to contribute to the evidence on interventions serving families with children who are eligible for or at risk of becoming eligible for Temporary Assistance for Needy Families (TANF). Recipients will also develop clear plans for sustaining an evidence-driven organizational culture beyond the funding period of the award and will share project learnings and implications with appropriate research, policy, and practice audiences. Recipients are required to work with a federally funded, third-party technical assistance provider throughout the entirety of the award.

Eligibility: Eligibility is restricted to applicants that received awards funded under HHS-2021-ACF-OPRE-PE-1944 (Family Self-Sufficiency Demonstration Development Grants).  Applications from individuals (including sole proprietorships) and foreign entities are not eligible and will be disqualified from the merit review and funding under this funding opportunity. Faith-based and community organizations that meet the eligibility requirements are eligible to receive awards under this funding opportunity. Faith-based organizations may apply for this award on the same basis as any other organization, as set forth at and, subject to the protections and requirements of 45 CFR Part 87 and 42 U.S.C. 2000bb et seq., ACF will not, in the selection of recipients, discriminate against an organization on the basis of the organization's religious character, affiliation, or exercise.
FY2024 Transitional Living Program
Agency: Administration for Children & Families - ACYF/FYSB
Posted: 2024-04-04 | Closing date: 2024-06-07
Electronically submitted applications must be submitted no later than 11:59 pm Eastern Standard Time on the listed application due date.
Estimated total program funding: 17004914
Award ceiling: 250000
Award floor: 100000
Expected number of awards: 68
Cost sharing or matching requirement: Yes

The Transitional Living Program (TLP) provides safe, stable, and appropriate shelter for runaway and homeless youth ages 16 to under 22 for up to 18 months and, under extenuating circumstances, can be extended to 21 months. TLPs provide comprehensive services that supports the transition of homeless youth to self-sufficiency and stable, independent living. Through the provision of shelter and an array of comprehensive services, TLP youth will realize improvements in four core outcome areas (i.e., safe and stable housing, education/employment, permanent connections, and social and emotional well-being).

Eligibility: Public (state and local) and private nonprofit entities and coordinated networks of such entities, are eligible to apply unless they are part of the juvenile justice system. For profit organizations are not eligible. Private institutions of higher education must be non-profit entities. In selecting applications for to receive grants under the TLP, priority will be given to public and non-profit private agencies that have experience in providing services to runaway, homeless, and street youth.  Applications from individuals (including sole proprietorships) and foreign entities are not eligible and will be disqualified from the merit review and funding under this funding opportunity. Faith-based and community organizations that meet the eligibility requirements are eligible to receive awards under this funding opportunity. Faith-based organizations may apply for this award on the same basis as any other organization, as set forth at and, subject to the protections and requirements of 45 CFR Part 87 and 42 U.S.C. 2000bb et seq., ACF will not, in the selection of recipients, discriminate against an organization on the basis of the organization's religious character, affiliation, or exercise.
Partner Promotion of Strategies to Advance Oral Health
Agency: Centers for Disease Control - NCCDPHP
Posted: 2024-04-04 | Closing date: 2024-06-03
Electronically submitted applications must be submitted no later than 11:59 pm ET on the listed application due date.
Estimated total program funding: 1800000
Award ceiling: 300000
Award floor: 100000
Expected number of awards: 3
Cost sharing or matching requirement: No

Partner Promotion of Strategies to Advance Oral Health is a three-year competitive announcement that continues the Centers for Disease Control and Prevention’s (CDC) investment in supporting oral health programs. This Funding Opportunity Announcement aims to support recipients of CDC-RFA-DP-24-0048 (State Promotion of Strategies to Advance Oral Health) to prevent and control oral diseases and related conditions among priority populations. Applicants may apply for Component 1, Component 2, or Component 3 separately. For all Components, the funded recipient(s) will work closely with staff from CDC’s Division of Oral Health and all awardees of CDC-RFA-DP-24-0048. Under Component, the recipient will provide awardees TA and resources to expand CWF and EBPDS activities among populations of focus. Under Component 2, the recipient will support IPC partnerships and activities among populations of focus. Under Component 3, the recipient will analyze secondary data to inform the future integration of medical and dental services for individuals with diabetes; analyze EBPDS data to understand access and use among populations of focus; and evaluate CWF, EBPDS, and IPC activities and partnerships of CDC-RFA-DP-24-0048 recipients. The proposed program will follow and build upon the Notice of Funding Opportunity for DP18-1811 [FY2018-FY2023].

Eligibility: Ministries of Health are not eligible.
FY 2024 Basic Center Program
Agency: Administration for Children & Families - ACYF/FYSB
Posted: 2024-04-04 | Closing date: 2024-06-07
Electronically submitted applications must be submitted no later than 11:59 pm Eastern Standard Time on the listed application due date.
Estimated total program funding: 18000000
Award ceiling: 250000
Award floor: 50000
Expected number of awards: 72
Cost sharing or matching requirement: Yes

The Basic Center Program (BCP) provides temporary shelter and counseling services to youth who have left home without permission of their parents or guardians, have been forced to leave home, or other homeless youth who might otherwise end up in the law enforcement or in the child welfare, mental health, or juvenile justice systems. BCPs work to establish or strengthen community-based programs that meet the immediate needs of runaway and homeless youth and their families. BCP award recipients provide youth under 18 years of age with emergency shelter, food, clothing, counseling and referrals for health care. BCP award recipients can provide up to 21 days of shelter for youth and seeks to reunite young people with their families, whenever possible, or to locate appropriate alternative placements. Additional services may include: street-based services; home-based services for families with youth at risk of separation from the family; drug abuse education and prevention services; and at the request of runaway and homeless youth, testing for sexually transmitted diseases.

Eligibility: Eligible applicants include public and non-profit private agencies and coordinated networks of such entities. For-profit organizations are not eligible. Private institutions of higher education must be non-profit entities. In selecting applicants to receive grants under this funding announcement, priority will be given to public and non-profit, private agencies that have experience in providing services to runaway, homeless, and street youth. Applications from individuals (including sole proprietorships) and foreign entities are not eligible and will be disqualified from the merit review and funding under this funding opportunity. Faith-based and community organizations that meet the eligibility requirements are eligible to receive awards under this funding opportunity. Faith-based organizations may apply for this award on the same basis as any other organization, as set forth at and, subject to the protections and requirements of 45 CFR Part 87 and 42 U.S.C. 2000bb et seq., ACF will not, in the selection of recipients, discriminate against an organization on the basis of the organization's religious character, affiliation, or exercise.
Environmental Regulatory Enhancement
Agency: Administration for Children and Families - ANA
Posted: 2024-03-19 | Closing date: 2024-05-22
Electronically submitted applications must be submitted no later than 11:59 pm Eastern Standard Time on the listed application due date.
Estimated total program funding: 2000000
Award ceiling: 300000
Award floor: 100000
Expected number of awards: 3
Cost sharing or matching requirement: Yes

This NOFO has been modified to change the application due date, as a result of changes to the Grants.gov maintenance schedule.The Administration for Children and Families, Administration for Native Americans announces the availability of Fiscal Year 2024 funds for community-based projects for the Environmental Regulatory Enhancement (ERE) program. The ERE program provides funding for the costs of planning, developing, and implementing programs designed to improve the capability of tribal governing bodies to regulate environmental quality pursuant to federal and tribal environmental laws.

Eligibility: Pursuant to 42 U.S.C. §2991b and 45 CFR §1336.33, eligible applicants under this announcement are:Federally-recognized Indian tribes, as recognized by the Bureau of Indian Affairs (BIA); Incorporated non-federally recognized tribes; Incorporated state-recognized Indian tribes; Non-profit Alaska Native community entities or tribal governing bodies (Indian Reorganization Act (IRA) or traditional councils) as recognized by the BIA; Non-profit Alaska Native Regional Associations and/or Corporations with village specific projects; Other tribal or village organizations or consortia of Indian tribes or Tribal governing bodies (IRA or traditional councils) as recognized by the BIA.Eligible applicants include Alaska Native villages as defined in the Alaska Native Claims Settlement Act and/or non-profit village consortia; non-profit Alaska Native Regional Corporations/Associations with village-specific projects; other tribal or village organizations or consortia of Indian tribes; and tribal governing bodies (Indian Reorganization Act or traditional councils) as recognized by the Bureau of Indian Affairs. Applications from individuals (including sole proprietorships) and foreign entities are not eligible and will be disqualified from the merit review and funding under this funding opportunity. Faith-based and community organizations that meet the eligibility requirements are eligible to receive awards under this funding opportunity. Faith-based organizations may apply for this award on the same basis as any other organization, as set forth at and, subject to the protections and requirements of 45 CFR Part 87 and 42 U.S.C. 2000bb et seq., ACF will not, in the selection of recipients, discriminate against an organization on the basis of the organization's religious character, affiliation, or exercise.
WaterSMART Planning and Design Grants
Agency: Bureau of Reclamation
Posted: 2023-08-07 | Closing date: 2024-05-23
This NOFO covers two application submittal periods.Proposals received prior before Tuesday, October 17, 2023, at 4:00 p.m. Mountain Daylight Savings Time will be considered for FY 2023 funding.Proposals received after October 17, 2023, and before May 23, 2024, at 4:00 p.m. Mountain Daylight Savings Time will be considered for FY 2024 funding, contingent on appropriations.
Award ceiling: 400000
Award floor: 1
Cost sharing or matching requirement: Yes

See application package and related documents

Eligibility: Applicants eligible to receive financial assistance to fund activities under this NOFO include:Water Strategy Grants and Project Design GrantsCategory A applicants: States, Tribes, irrigation districts, and water districts; State, regional, or local authorities, the members of which include one or more organizations with water or power delivery authority; and other organizations with water or power delivery authority.All applicants must be located in one of the following States or territories: Alaska, Arizona, California, Colorado, Hawaii, Idaho, Kansas, Montana, Nebraska, Nevada, New Mexico, North Dakota, Oklahoma, Oregon, South Dakota, Texas, Utah, Washington, Wyoming, American Samoa, Guam, the Northern Mariana Islands, the Virgin Islands, and Puerto Rico.Category B applicants: Nonprofit conservation organizations that are acting in partnership with, and with the agreement of, an entity described in Category A. All Category B applicants must be located in the United States or the specific territories identified above. Category B applicants must include with their application a letter from the Category A partner stating that the Category A partner: (1) is acting in partnership with the applicant; (2) agrees to the submittal and content of the application; and (3) intends to participate in the project in some way, for example, by providing input, feedback, or other support for the project.Drought Contingency PlanningA State, Tribe, irrigation district, water district, or other organization with water or power delivery in one of the following states or territories: Arizona, California, Colorado, Hawaii, Idaho, Kansas, Montana, Nebraska, Nevada, New Mexico, North Dakota, Oklahoma, Oregon, South Dakota, Texas, Utah, Washington, Wyoming, American Samoa, Guam, the Northern Mariana Islands, or the Virgin Islands
Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2026-11-05
Award ceiling: 250000
Cost sharing or matching requirement: No

The purpose of this Notice of Funding Opportunity (NOFO) is to advance the development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights. NLM seeks applications that further the science of personal health informatics by providing meaningful and actionable insights to individuals through innovative personal health data collection, integration, analysis, and personalized risk assessments and interpretation. Applications seeking to advance the understanding of how informatics tools, systems, and platforms can best present the results, interpretation, and limitations of personalized assessments for the benefit of individuals are encouraged. Applications should include end user engaged approaches and real-world evaluation to inform the design of generalizable, reusable, and scalable personal health informatics tools, systems, and platforms for the benefit of individuals in understanding and improving their health.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-08 | Closing date: 2027-01-07
Award ceiling: 500000
Cost sharing or matching requirement: No

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to stimulate translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, treatment, and/or disease status for cancer or other disease.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Alcohol Health Services Research (R34 Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2026-09-07
Award ceiling: 450000
Cost sharing or matching requirement: No

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Alcohol Health Services Research (R01 Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2026-09-07
Award ceiling: 500000
Cost sharing or matching requirement: No

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2026-09-07
Award ceiling: 500000
Cost sharing or matching requirement: No

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research. This NOFO will focus broadly on topics relevant for treatment of and recovery from alcohol use disorder (AUD), including: medications development, precision medicine, behavioral therapies and mechanisms of behavioral change (MOBC), recovery, translational research, and innovative methods and technologies for AUD treatment and recovery.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Alcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2026-09-07
Award ceiling: 450000
Cost sharing or matching requirement: No

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Forward-Looking Experimentation (FLEX)
Agency: DARPA - Microsystems Technology Office 
Posted: 2023-08-09 | Closing date: 2024-08-09
See Full Announcement for details.
Cost sharing or matching requirement: No

The Microsystems Technology Office at DARPA seeks fundamental research proposals for disruptive ideas in information and communication technologies (ICT) addressing the grand challenges for a data-driven future. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. The goal of the Forward-Looking Experimentation (FLEX) program is to identify the direction and timing of key disruptive advances in ICT, accelerate technology exploration and generate intellectual property, develop next-generation researchers for the U.S. workforce, and build the foundation for future research programs.

Eligibility: All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA.  See the Eligibility Information section of the BAA for more information.
NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2025-11-03
Cost sharing or matching requirement: No

This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for laboratory-based scientists.The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional scientists who want to continue to pursue research within the context of an existing NCI-funded basic, translational, clinical, or population science cancer research program, but not serve as independent investigators. These non-tenure track scientists, such as researchers within a research program, are vital to sustaining the biomedical research enterprise. It is anticipated that only exceptional scientists who want to pursue research within the context of an existing NCI-funded cancer research program, but not serve as independent investigators, will be competitive for this award.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
NCI Research Specialist (Laboratory-based Scientist) Award (R50 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Posted: 2023-08-09 | Closing date: 2025-11-03
Cost sharing or matching requirement: No

This Funding Opportunity Announcement (FOA) invites grant applications for the Research Specialist Award (R50) in any area of NCI-funded cancer research. This FOA is specifically for laboratory-based scientists.The Research Specialist Award is designed to encourage the development of stable research career opportunities for exceptional scientists who want to continue to pursue research within the context of an existing NCI-funded basic, translational, clinical, or population science cancer research program, but not serve as independent investigators. These non-tenure track scientists, such as researchers within a research program, are vital to sustaining the biomedical research enterprise. It is anticipated that only exceptional scientists who want to pursue research within the context of an existing NCI-funded cancer research program, but not serve as independent investigators, will be competitive for this award.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.  Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.  Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Assay development and screening for discovery of chemical probes, drugs or immunomodulators (R01 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Posted: 2023-08-10 | Closing date: 2026-09-07
Cost sharing or matching requirement: No

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science
Agency: National Science Foundation
Posted: 2023-08-11 | Closing date: 2024-10-03
Estimated total program funding: 20000000
Award ceiling: 1200000
Expected number of awards: 16
Cost sharing or matching requirement: No

The purpose of this interagency program solicitation is to support the development of transformative high-risk, high-reward advances in computer and information science, engineering, mathematics, statistics, behavioral and/or cognitive research to address pressing questions in the biomedical and public health communities. Transformations hinge on scientific and engineering innovations by interdisciplinary teams that develop novel methods to intuitively and intelligently collect, sense, connect, analyze and interpret data from individuals, devices and systems to enable discovery and optimize health. Solutions to these complex biomedical or public health problems demand the formation of interdisciplinary teams that are ready to address these issues, while advancing fundamental science and engineering.

Eligibility: *Who May Submit Proposals: Proposals may only be submitted by the following:   -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities.   -Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting      on behalf of their faculty members.Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an      international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain      the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
Understanding Expectancies in Cancer Symptom Management (R01 Clinical Trial Required)
Agency: National Institutes of Health
Posted: 2023-08-10 | Closing date: 2026-05-07
Cost sharing or matching requirement: No

This Notice of Funding Opportunity (NOFO) is intended to support mechanistic research that aims to understand how and why expectancy effects occur in a cancer context, elucidate their role in cancer symptom management, and identify patients, symptoms, cancer sites, and contexts in which expectancy effects can be leveraged to improve cancer outcomes. Expectancies are defined in this context as beliefs about future outcomes, including ones response to cancer or cancer treatment. Expectancies can be evoked by social, psychological, environmental, and systemic factors. Expectancy effects are the cognitive, behavioral, and biological outcomes caused by expectancies. Expectancy effects can be generated by expectancies held by patients, clinicians, family members, caregivers, and/or dyadic/social networks. NCI is particularly interested in applications that enroll individuals and groups from populations historically underrepresented or excluded from biomedical and behavioral research.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-10 | Closing date: 2025-02-06
Cost sharing or matching requirement: No

This notice of funding opportunity (NOFO) seeks to support research aimed at holistic understanding of inter-individual or between-person differences in human pain conditions, focusing on Whole Person Health and enhancing pain treatment and management strategies towards personalized pain medicine. The goal of this NOFO is to support studies that focus on the collection of clinical and/or preclinical data to enable evidence-based modeling and understanding of inter-individual differences and/or heterogeneity of pain occurring with use of pain therapy/management, or with conditions such as a second pain condition, a comorbid health condition, a comorbid mental health condition, or conditions of use / misuse of opioids, alcohol or other substances. Applicants are encouraged to develop and implement novel, multidisciplinary research approaches, and include investigators with complementary expertise to fulfill the project and program goals. Input from patients and caregivers on the goals of the project is highly encouraged. Rigorous data-driven and evidence-based research approaches supported under this NOFO are expected to provide better understanding of biological and/or biopsychosocial underpinnings of inter-individual differences, heterogeneity, and stratification of persons with lived pain experience, which would accelerate the development of evidence-based solutions toward precision pain medicine.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Posted: 2023-08-11 | Closing date: 2026-05-05
Cost sharing or matching requirement: No

The Adolescent Brain Cognitive Development (ABCD) Study is the largest longitudinal study of brain development and child health collecting data from more than 11,000 children across the U.S. beginning when they are 9-10 years old and continuing for a decade. In addition to behavioral assessments, youth undergo neuroimaging and provide biospecimens, including saliva for hormone analysis, urine and hair for substance use and exposure, deciduous teeth for environmental exposure, and blood for genetic analysis and metabolic and hematologic assays. This initiative allows investigators to apply for access to biological samples from the ABCD Study. More information about the ABCD Study may be found on the ABCD Study website (www.abcdstudy.org). Information about this resource can be found on the NIDA funding opportunities page at https://nida.nih.gov/funding/nida-funding-opportunities/nih-brain-development-cohorts-biospecimen-access-program.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Centers of Excellence to Enhance Disease Detection in Newborns
Agency: Centers for Disease Control - NCEH
Posted: 2024-04-04 | Closing date: 2024-06-04
Electronically submitted applications must be submitted no later than 11:59 pm ET on the listed application due date.
Estimated total program funding: 4000000
Award ceiling: 1000000
Award floor: 750000
Expected number of awards: 1
Cost sharing or matching requirement: No

The use of dried blood spots to screen newborns for serious diseases has had a significant impact in saving lives and improving developmental outcomes since 1963. The adoption of new technologies into public health laboratory workflows has made it possible to screen newborns for an increasing number of diseases. Today, advanced technologies, such as Next Generation Whole Genome Sequencing and High-Resolution Mass Spectrometry, can enhance key aspects of newborn screening (NBS) practice, including early detection of current and newly added diseases. However, incorporating these advanced and complex technologies into NBS often requires substantial resources. To enhance NBS practice, CDC announces a new NOFO for a public health laboratory to establish a NBS Center of Excellence that will 1) develop infrastructure to implement existing, advanced technologies to expand NBS system capacity, 2) use advanced technologies as second and third tier testing platforms to optimize screening performance, and 3) incorporate bio-informatics to analyze complex biochemical and molecular data. Over the four-year project, the recipient will pilot methods to enhance NBS practices in public health laboratories, collaborate and share findings with the NBS community, and partner with CDC subject-matter experts on data harmonization and modernization efforts. This project will better position NBS programs to adapt to advanced technologies and meet increasing demands within NBS.

Eligibility: Applicants must represent or be an administrative partner to an established state or territorial newborn screening program. Applicants must be able to implement and sustain new newborn screening programs in a U.S. state or territory.
USDA Forest Service Inflation Reduction Act Forest Landowner Support
Agency: Forest Service
Posted: 2023-08-22 | Closing date: 2024-08-21
Track B: Proposal budgets less than $2 million will be considered for funding on a quarterly basis. Proposals received in each of these listed windows will be evaluated together as separate batches: August 21, 2023 - November 30, 2023; December 1, 2023 - February 29, 2024; March 1, 2024 - May 31, 2024; June 1, 2024 - August 21, 2024.        Track A: The submission deadline has passed for proposals with budgets greater than or equal to $2 million and less than $25 million.         Track C: Proposals to administer a national competitive regranting program may also be considered. Budgets must be greater than or equal to $5 million, less than $50 million, and include at least 80% sub-awards.
Estimated total program funding: 150000000
Award ceiling: 50000000
Award floor: 0
Cost sharing or matching requirement: No

This notice of funding opportunity (NOFO) is the first in an anticipated series of Landowner Support for Forest Resilience NOFOs. Landowner Support for Forest Resilience is currently funded by four Inflation Reduction Act (IRA) provisions (Public Law No: 117-169. Subtitle D, Sec. 23002(a) (1 ), (2), (3), and (4)), which encompass cost share and payment incentives for forestry practices and support participation of underserved landowners and small-acreage landowners (owning less than 2,500 acres) in emerging private markets for climate mitigation or forest resilience. Landowner Support for Forest Resilience falls under the USDA Forest Service's existing Landscape Scale Restoration Program, as authorized under Section 13A of the Cooperative Forestry Assistance Act of 1978 (16 U.S.C. 2109a). This program advances the Biden-Harris Administration's Justice40 Initiative. Established by Executive Order 14008 on Tackling the Climate Crisis at Home and Abroad, the Justice40 Initiative has made it a goal that 40 percent of the overall benefits of certain federal investments, such as climate, clean energy, and other areas, flow to disadvantaged communities. This notice of funding opportunity (NOFO) solicits proposals for two IRA provisions: Subtitle D, Sec. 23002 (a)(2) and Subtitle D, Sec. 23002 (a)(3). These provisions provide the USDA Forest Service with funding to:Support the participation of underserved forest landowners in emerging private markets for climate mitigation or forest resilience.Support the participation of forest landowners who own less than 2,500 acres of forest land in emerging private markets for climate mitigation or forest resilience.

Inflation Reduction Act
Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)
Agency: National Institutes of Health
Posted: 2023-08-15 | Closing date: 2027-01-07
Cost sharing or matching requirement: No

This Notice of Funding Opportunity (NOFO) aims to support research on interdisciplinary population approaches to increasing awareness of the relationship between alcohol and cancer risk, understanding and changing social norms related to alcohol consumption, developing and/or evaluating alcohol policy approaches, and the development, testing, and implementation of population-level interventions to reduce alcohol-related cancer risk. Applications that address multiple levels of consumption, such as moderate and heavy drinking, are of particular interest, as well as those focusing on alcohol use disorder (AUD) from the perspective of cancer prevention and control. Proposals addressing understudied areas are encouraged, as is attention to underrepresented minority (URM) populations experiencing cancer and alcohol-related disparities such as American Indian, Alaskan Native, and sexual and gender minority populations.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Planning for Product Development Strategy (R34 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Posted: 2023-08-14 | Closing date: 2026-12-04
Award ceiling: 225000
Cost sharing or matching requirement: No

The purpose of this Notice of Funding Opportunity (NOFO) is to support the development of a comprehensive and well-defined product development strategy for next-generation treatments for HIV and HIV-associated comorbidities, coinfections and complication and preventive strategies for HIV, as well as facilitating the translation of research findings into drug products that enables submission of an Investigational New Drug (IND) application to the FDA.

Eligibility: Other Eligible Applicants include the following:  Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.