THE COMBINATION OF HYDRIODIC ACID, WATERY OR OILY, OR SALTS OF IODINE, WITH TANNIC ACID, THE CONSTITUTING PARTS OF CINCHONA, OR OF SARSAPARILLA, OR OF THE LEAVES AR MEN WAT AM IRON OR WITH ONE OD SEVEDAT AD AR πα
Year: 1855

page_text: LETTERS PATENT to Dupont de Bussac, of Brussels, and of 32, Essex
Street, Strand, London, for the Invention of "THE COMBINATION OF
HYDRIODIC ACID, WATERY OR OILY, OR SALTS OF IODINE, WITH TANNIC ACID,
THE CONSTITUTING PARTS OF CINCHONA, OR OF SARSAPARILLA, OR OF THE LEAVES
AR MEN WAT AM IRON OR WITH ONE OD SEVEDAT
AD
AR πατου
Sealed the 15th February 1856, and dated the 22nd August 1855.
PROVISIONAL SPECIFICATION left by the said Dupont de Bussac at the
Office of the Commissioners of Patents, with his Petition, on the 22nd
August 1855.
I; DUPONT DE BUSSAC, of Brussels, and of $2, Essex Street, Strand, London,
do hereby declare the nature of the said Invention for "THE COMBINATION OF
HYDRIODIC ACID, WATERY OR OILY, OR SALTS OF IODINE, WITH TANNIC ACID, THE
CONSTITUTING PARTS OF CINCHONA, OR OF SARSAPARILLA, OR OF THE LEAVES OF THE
WALNUT TREE, AND IRON, OR WITH ONE OR SEVERAL OF THESE BODIES," to, be as
follows; and consists in the formation of hydriodated salts in various ways.
Firstly, I heat in a glass mortar, Ist, distilled water; 2nd, tannic acid; 3rd,
a simple equivalent or a multiple of iodine, until the. iodine be transformed
into hydriodic acid; or an equivalent of tannic acid may be dissolved in a simple
equivalent or multiple of aqueous hydriodic acid. In such case a hydriodate of

page_text: tannin is formed.
The raw alkaloids of cinchona or their salts are dis-
solved in their simple equivalent or multiple of hydriodic acid combined in it.
By mixing the above-mentioned salts there is formed a double hydriodate of
tannin and quinine alkalis. Iodide of iron is mixed with the tannic acid, first
dissolved in its simple or double equivalent of hydriodic acid. An intimate
mixture is thus made of the iron and tannin without a precipitate of tannate
of peroxyd of iron. At the end of some time the liquid assumes a greenish
colour, which is generally the case with all proto-salts of iron, but this tint may
be got rid of by mixing a little loaf sugar with the liquid; syrup of iodide of
iron may also be used for this purpose. When the above-mentioned salts
have thus been formed seperately, it is sufficient to mix them to obtain a
complex salt, that is to say, hydriodate of tannin, of cinchona, and of iron.
The principle of equivalents prevents the precipitation of the tannate of iron,
but not the precipitation of the peroxyd of iron. To prevent or decompose
this last precipitation it is sufficient to mix with the liquid, cold or heated, a
small quantity of sugar, or of syrup of iodide of iron. To the hydriodate of
tannin and quinine alkalis a simple salt of iron may be added without its
equivalent of hydriodic acid. By heating the liquid and mixing sugar with it
the formation of tannate of iron will be prevented, and a hydriodate of tannin,
cinchona, and iron will be obtained.
Secondly, the tannate of quinine alkaloids, or the extract more or less con-
centrated of cinchona, are mixed with one or more equivalents of hydriodic
acid in a liquid state. This forms a hydriodate of tannin, of quinine alkalis, and
of iron.
Thirdly, the powder of cinchona is treated by the method of displacement by
means of the hydriodic acid liquid. This acid, more or less concentrated, may
be employed heated or cold. It is better that the heat be not above 50 degrees
centigrade. When the hydriodic acid has finished its action, the bark is further
exhausted by means of distilled water. The produce of this aqueous displace-
ment may be more or less concéntrated by evaporation, and afterwards mixed
with the produce of the first displacement made by means of the acid. This
forms a hydriodate of cinchona, containing tannin, alkaloids, and resin of cin-
chona. In this state hydriodate of cinchona may not be a definite salt. It is
better first to analyze the proportional quantities of tannin and alkaloids that
the bark of cinchona, and to treat them afterwards by one or several equivalents
of hydriodic acid. The same method of displacement as above described is
employed. When the displacement is terminated, an after analysis will shew
if the salt contains exactly the equivalents of all the parts which ought to con

page_text: stitute it; and should this analysis make it evident that there is a deficiency of
iodine, the quantity of hydriodic acid sufficient to make the equivalent simple
or double should be added. Should alkaloids or tannin be wanting, 'the defi-
ciency must be made up by the addition of quinine alkalis or tannic acid, that
may be dissolved in a small quantity of hydriodic acid and mixed with the
liquid to complete the salt; and if during this operation some precipitate of
quinine alkaloids be created, it is dissolved by adding a suitable quantity
When
of hydriodic acid, and the geueral equivalent is thus re-established.
hydriodate of cinchona containing an equivalent of hydriodic acid is obtained;
iron may be added by the processes before explained, and] hydriodate of
cinchona and iron is formed.
Fourthly, in a glass mortar, powder of cinchona, distilled water, and liquid
hydriodic acid are placed, and made to boil gently one or several times. All
the constituting parts of the cinchona are extracted by the hydriodic acid com-
bining them with it, and thus forming a hydriodate of cinchona.
And, fifthly, instead of aqueous hydriodic acid, oily hydriodic acid may be
used to dissolve the rough alkaloids of cinchona, or the different salts of quininė
alkaloids or salts of iron combined together or seperately form fatty hydriodates.
To mix more easily the iron, an iodide of iron may be used, in the preparation:
of which distilled water is replaced by oil. With oily hydriodic acid a suffi-
cient action may be obtained on the bark of cinchona, sarsaparilla, or walnut
leaves either by the method of displacement or by ebullition. It is better
to free the bark of its tannin and to dry it. The action may also be obtained
by pure iodine and oil.
SPECIFICATION in pursuance of the conditions of the Letters Patent, filed
by the said Dupont de Bussac in the Great Seal Patent Office on the
16th February 1856.
TO ALL TO WHOM THESE PRESENTS SHALL COME, I, DUPONT
DE BUSSAC, of Brussels, and of 32, Essex Street, Strand, London, send
greeting.
WHEREAS Her most Excellent Majesty Queen Victoria, by Her Letters
Patent, bearing date the Twenty-second day of August, in the year of our
Lord One thousand eight hundred and fifty-five, in the nineteenth year of
Her reign, did, for Herself, Her heirs and successors, give and grant unto
me, the said Dupont de Bussac, Her special licence that I, the said Dupont

page_text: de Bussac, my executors, administrators, and assigns, or such others as I,
the said Dupont de Bussac, my executors, administrators, and assigns, should
at any time agree with, and no others, from time to time and at all times
thereafter during the term therein expressed, should and lawfully might make,
use, exercise, and vend, within the United Kingdom of Great Britain and
Ireland, the Channel Islands, and Isle of Man, an Invention for "THE COM-
BINATION OF HYDRIODIC ACID, WATERY OR OILY, OR SALTS OF IODINE, WITH TANNIC
ACID, THE CONSTITUTING PARTS OF CINCHONA, OR OP SARSAPARILLA, OR OF THE LEAVES
OF THE WALNUT TREE, AND IRON, OR WITH ONE OR SEVERAL OF THESE BODIES,"
upon the condition (amongst others) that I, the said Dupont de Bussac, by
an instrument in writing under my hand and seal, should particularly describe
and ascertain the nature of the said Invention, and in what manner the same
was to be performed, and cause the same to be filed in the Great Seal Patent
Office within six calendar months next and immediately after the date of the
said Letters Patent.
per-
NOW KNOW YE, that I, the said Dupont de Bussac, do hereby declare
the nature of my said Invention, and in what manner the same is to be
formed, to be particularly described and ascertained in and by the following
statement:-
This Invention consists in the formation of hydriodated salts in various
ways.
chinconns
Firstly, I heat in a glass mortar, 1st, distilled water; 2nd, tannic acid; 3rd, a
simple equivalent or a multiple equivalent of iodine, until the iodine be trans-
formed into hydriodic acid; or an equivalent of tannic acid may be dissolved in
a simple equivalent or multiple equivalent of aqueous hydriodic acid. In such
case a hydriodate of tannin is formed. The raw alkaloids of cinchona or their
salts are dissolved in their simple equivalent or multiple equivalent of hydri-
odic acid, and combine in it. By mixing the two above-mentioned salts there
is formed a double hydriodate of tannin and quinine alkaloides. Iodide
of iron is mixed with tannic acid, first dissolved in its simple or double
equivalent of hydriodic acid. An intimate mixture is thus made of the iron
and tannin without any precipitate of tannate of peroxyd of iron. At the end
of some time the liquid assumes a greenish colour, which is generally the case
with all proto-salts of iron; but this tint may be got rid of by mixing a little
loaf sugar with the liquid. Syrup of iodide of iron may also be used for this
purpose. When the above-mentioned salts have thus been formed separately,
it is sufficient to mix them to obtain a complex salt, that is to say, a hydriodate
of tannin, of cinchona, and of iron. The principle of equivalents prevents the

page_text: precipitation of the taunate of iron, but not the precipitation of the peroxyd of
iron. To prevent or to decompose this last precipitation, it is sufficient to mix
with the liquid, cold or heated, a small quantity of sugar, or of syrup of iodide.
cinchona
of iron. To the hydriodate of tannin and of quinine alkalis a simple salt of
iron may be added without its equivalent of hydriodic acid. By heating
the liquid and mixing sugar with it, the formation of tannate of iron will be
prevented, and a hydriodate of tannin, cinchona, and iron will be obtained.
cinchona
Secondly, the tannate of quinine alkaloids, or the extract more or less
concentrated of cinchona, are mixed with one or more equivalents of hydriodic
cinchona
acid in a liquid state. This forms a hydriodate of tannin, of quinine alkalis,
and of iron, when iron is added by the processes before explained.
Thirdly, the powder of cinchona is treated by the method of displacement
by means of the hydriodic acid liquid. This acid more or less concentrated
may be employed heated or cold; it is better that the heat be not above 50
degrees centigrade. When the hydriodic acid has finished its action the bark
is further exhausted by means of distilled water. The produce of this
aqueous displacement may be more or less concentrated by evaporation, and
afterwards mixed with the produce of the first displacement made by means of
the acid. This forms a hydriodate of cinchona, containing tannin, alkaloids,
and resin of cinchona. In this state hydriodate of cinchona may not be a
definite salt. It is better first to analyse the proportional quantities of tannin
and alkaloids that the bark of cinchona contains, and to treat them afterwards
by one or several equivalents of hydriodic acid; the same method of displace-
ment as above described is employed. When the displacement is terminated
an after analysis will show if the salt contains exactly the equivalents of all the
parts which ought to constitute it. Should this analysis make it evident that
there is a deficiency of iodine, the quantity of hydriodic acid sufficient to make
the equivalent simple or double should be added. Should alkaloids or tannin
be wanting, the deficiency must be made up by the addition of quinine
alkalis or tannic acid, that may be dissolved in a small quantity of hydriodic
acid, and mixed with the liquid to complete the salt, and if during this
operation some precipitate of quinine alkaloids be created, it is dissolved
by adding a suitable quantity of hydriodic acid, and the general equivalent
is thus re-established. When hydriodate of cinchona containing a simple or
multiple equivalent of hydriodic acid is obtained, iron may be added by the
processes before explained, and a hydriodate of cinchona and iron is formed.
cinchona
cinchona

page_text: Fourthly, in a glass mortar, powder of cinchona, distilled water, and liquid
hydriodic acid are placed, and made to boil gently one or several times; all the
constituting parts of the cinchona are extracted by the hydriodic acid
combining them with it, and thus forming a hydriodate of cinchona. +
cinchona
And, fifthly, instead of aqueous hydriodic acid, oily hydriodic acid may be
used to dissolve the rough alkaloids of cinchona, or the different salts of
quinine alkaloids, or salts of iron, to combine them, together or seperately,
and form fatty hydriodates. To mix more easily the iron, an iodide of iron
may be used, in the preparation of which distilled water is replaced by oil.
With oily hydriodic acid a sufficient action may be obtained on the bark of
cinchona, sarsaparilla, or walnut leaves, either by the method of displacement,
or by ebullition; it is better to free the bark of its tannin and to dry it.
The action may also be obtained by pure iodine and oil. Fatty hydriodates
are thus formed.
Having thus described the nature of my Invention, and the manner. in
which the same is or may be carried into effect, I wish it to be distinctly
understood that what I claim as novel, and being secured to me by the herein-
before in part recited Letters Patent, is, the formation of hydriodated salts in
the various ways herein-before mentioned.
In witness whereof, I, the said Dupont de Bussac, have hereunto set
my hand and seal, this Twelfth day of February, in the year of
Land One thousand night hundred and fifty-siv