Improvements in the Preparation of Antiseptics.
Year: 1893

page_text: Date of Application, 26th Apr., 1893
Complete Specification Left, 26th Jan., 1894-Accepted, 3rd Mar., 1894
PROVISIONAL SPECIFICATION.
Improvements in the Preparation of Antiseptics.
I, SYDNEY PITT, of Sutton, in the County of Surrey, Gentleman, '(a
communication to me from abroad by The Chemische Fabrik auf Actien vorm.
E. Schering, of 170 Müllerstrasse, Berlin,) do hereby declare the nature of this
invention to be as follows:-
Most antiseptics applied in medicine more especially in surgery have the
peculiar effect of coagulating albuminous solutions by forming insoluble compounds
with the albumen present.
By this transformation into insoluble compounds the antiseptic effects are
considerably hindered. Disproportionately larger quantities of these antiseptics
must therefore be taken to obtain the necessary results at the risk of producing
caustic and toxic effects.
My correspondents have found that certain organic bases exist which are neither
caustic nor toxic and which are at the same time capable of dissolving a number of
the most commonly used antiseptics bringing them into a form which will not
coagulate albumen. The antiseptic value of these new strongly alkaline solutions
is considerably greater than that of the simple watery solution of the respective
antiseptic similarly concentrated.
The antiseptics so treated with the organic bases hereinafter described are no
longer precipitated by albumen and are therefore rendered more active especially
because the membranes of the bacilli swell up and are almost dissolved by the
influence of the organic bases employed. The latter circumstance therefore
considerably increases the antiseptic value.
The organic bases here especially referred to are the following:
Ethylenediamine and its alkyl derivatives and also the bases obtainable from
monochlorhydrin, dichlorhydrin, epichlorhydrin and ammonia and also piperazine.
The antiseptics which form solutions with these organic bases not coagulated
by albumen are:
1. Phenyl bodies such as carbolic acid, cresylic acid, xylenols, thymol, naphthols,
creosol, guaiacol, and-
2. Both inorganic and organic silver salts.
The solutions of the phenyl bodies may be prepared as follows:
To
10 parts basic ethylenediamine are dissolved in about 500 parts of water.
this are added about 10 parts freshly distilled coal tar cresylic acid under agitation.
The solution thus obtained is no longer capable of coagulating albumen. If cresylic
acid be replaced by creosote or guaiacol a larger proportion of basic ethylene-
diamine should be added.
For the manufacture of alkaline silver salt solutions which do not coagulate with
albumen 10 parts of phosphate of silver are gradually stirred with 10 parts of basic
ethylenediamine dissolved in 100 parts of water.
In place of the phosphate other inorganic silver salts such as nitrate or hydro-
chloride and also the organic silver salts may be employed.
The solutions thus prepared are suitably diluted for antiseptic requirements.
Dated this 06th do of Anul 1902

page_text: Improvements in the Preparation of Antiseptics.
I, SYDNEY PITT, of Sutton, in the County of Surrey, Gentleman, (a
communication to me from abroad by The Chemische Fabrik auf Actien vorm.
E. Schering, of 170 Müllerstrasse, Berlin,) do hereby declare the nature of this
invention and in what manner the same is to be performed to he particularly
described and ascertained in and by the following statement:-
Most antiseptics applied in medicine more especially in surgery have the
peculiar effect of coagulating albuminous solutions by forming insoluble compounds
with the albumen present.
By this transformation into insoluble compounds the antiseptic effects are
considerably hindered. Disproportionately larger quantities of these antiseptics
must therefore be taken to obtain the necessary results at the risk of producing
caustic and toxic effects.
My correspondents have found that certain organic bases exist which are neither
caustic nor toxic and which are at the same time capable of dissolving a number of
the most commonly used antiseptics bringing them into a form which will not
coagulate albumen. The antiseptic value of these new strongly alkaline solutions
is considerably greater than that of the simple watery solution of the respective
antiseptic similarly concentrated.
The antiseptics so treated with the organic bases hereinafter described are no
longer precipitated by albumen and are therefore rendered more active especially
because the membranes of the bacilli swell up and are almost dissolved by the
influence of the organic bases employed. The latter circumstance therefore
considerably increases the antiseptic value.
The organic bases here especially referred to are the following:
Ethylenediamine and its alkyl derivatives and also the bases obtainable from
monochlorhydrin, dichlorhydrin, epichlorhydrin and ammonia and also piperazine.
The antiseptics which form solutions with these organic bases not coagulated by
albumen are:
1. Phenyl bodies such as carbolic acid, cresylic acid, xylenols, thymol, naphthols,
creosol, guaiacol, and—
2. Both inorganic and organic silver salts.
The solutions of the phenyl bodies may be prepared as follows:
10 parts basic ethylenediamine are dissolved in about 500 parts of water. To
this are added about 10 parts freshly distilled coal tar cresylic acid under agitation.
The solution thus obtained is no longer capable of coagulating albumen. If cresylic
acid be replaced by creosote or guaiacol a larger proportion of basic ethylene-
diamine should be added:
For the manufacture of alkaline silver salt solutions which do not coagulate with
albumen 10 parts of phosphate of silver are gradually stirred with 10 parts of basic
ethylenediamine dissolved in 100 parts of water.
In place of the phosphate other inorganic silver salts such as nitrate or hydro-
chloride and also the organic silver salts may be employed.
The solutions thus prepared are suitably diluted for antiseptic requirements.
Having now particularly described and ascertained the nature of my said
invention and in what manner the same is to be performed I declare that what I
claim is :-
1. The preparation of antiseptics by means of organic bases which are neither
caustic nor toxic and are capable of dissolving the antiseptic bringing it into a
form which will not coagulate albumen substantially as described.
2. The preparation of antiseptics by dissolving (a) phenyl bodies such as carbolic

page_text: acid, cresylic acid, xylenols, thymol, naphthols, creosol and guaiacol, or (b) the
inorganic and organic silver sults; in ethylenediamine and its alkyl derivatives
and also the bases obtainable from monochlorhydrin, dichlorhydrin, epichlorhydrin
and ammonia and also piperazine, substantially as described.
3. The preparation of antiseptics substantially as described.
Dated this 22nd do of January 1904