An Improved Process for Obtaining Easily Soluble Preparations Containing Quinine and Caffeine.
Year: 1899

page_text: Date of Application, 19th Dec., 1899-Accepted, 3rd Feb., 1900
An Improved Process for Obtaining Easily Soluble Preparations
Containing Quinine and Caffeine.
A communication by the Firm of SCHRÖDER AND KRAMER, of 120, Spaldinstrasse,
Hamburg, in the Empire of Germany, Merchants and Chemical Manu-
facturers.
I, WILLIAM PHILLIPS THOMPSON, F.C.S., M.I.M.E., Agent for Foreign Patent
Solicitors, 6, Lord Street, Liverpool, and 6, Bank Street, Manchester, both in the
County of Lancaster, 118, New Street, Birmingham, in the County of Warwick,
and 322, High Holborn, in the County of Middlesex, Civil Engineer, do hereby
declare the nature of this invention and in what manner the same is to be
performed, to be particularly described and ascertained in and by the following
statement:-
Quinine and caffeine yield in the presence of hydrochloric (HCl), hydro-
bromic (HBr) or hydriodic (HI) acids, under suitable conditions, basic com-
pounds which are characterised by great solubility. These compounds as cannot
be doubted in view of the constitutents, form valuable medicaments, the effective-
ness of which is not only one corresponding to the constituents but also is a new
specific anti-toxin like one.
The process for making such preparations containing such easily soluble
preparations containing quinine and caffeine is as follows:
Two parts by weight of chloride of quinine (or bromide or iodide of quinine)
are mixed with about one part of caffeine and placed in a suitable vessel and
liquefied under gradually increasing heat, any over-heating at the sides being
avoided. The liquefaction takes place without any addition of a solvent, but
neutral solvents such as water, spirit, chloroform, or the like may also be
added.
After complete liquefaction is obtained, caffeine and chloride of quinine have
entered into a combination, which has essentially other physical properties than
its constituents. The molten mass obtained without the use of solvent is poured
out, and when it has set or hardened is rubbed down or ground. If it is to
be crystallised the molten substance is dissolved in a solvent.
The solution of the preparation obtained in this manner or after the constituents
have been rendered Huid by the addition of solvents, yields when evaporated,
solid crystals which dissolve in one part of water and are applicable for many
medicinal purposes either by themselves or in solution.
The proportionate quantities of the quinine salt and the caffeine may be changed
somewhat, for instance more or less caffeine may be employed than is herein-
before stated. Instead of the salt of quinine in question the constituents of
the same may also be employed in a suitable proportion.

page_text: Having now particularly described and ascertained the nature of the said
invention and in what manner the same is to be performed as communicated to
me by my foreign correspondents, I declare that what I claim is:
-
The production of easily soluble preparations containing caffeine and quinine,
and solutions of said preparations by the combination of the halogen compounds
of quinine, or their constituents, and caffeine by melting the constituents together
with or without the aid of solvents, substantially as herein before set forth.
Dated this 18th day of December 1899
W. P. THOMPSON & Co.,
Agents.