An Improved Process for the Manufacture of Lactyl-p-pheṇetidine.
Year: 1894

page_text: Date of Application, 9th Oct., 1894
Complete Specification Left, 8th July, 1895-Accepted, 10th Aug., 1895
4
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PROVISIONAL SPECIFICATION.
An Improved Process for the Manufacture of Lactyl-p-pheṇetidine.
1
I, JAMES YATE JOHNSON of 47 Lincoln's Inn Fields in the County of London
Gentleman do hereby declare the nature of this invention (which has been
communicated to me from abroad by C. F: Boehringer and Soehne of Waldbof
near Mannheim in the Empire of Germany) to be as follows:-
It is a well known fact that benzyliden compounds of primary aromatic amines
will readily decompose again under the action of diluted mineral acids, whereas
they will not do so under the action of concentrated sulphuric acid or under the
influence of acetic acid.
Now my foreign correspondents have found that laotic acid also, when, raised to
a high temperature, is capable of decomposing benzyliden-p-phenctidine while at
the same time producing lactyl-p-phenétidine.
The following is an example of the manner in which this invention can
be carried into practical effect but I do not limit myself to the precise details.
22-5 parts by weight of benzyliden-p-phenetidine are heated together with
12 parts by weight of lactic acid at 75 per cent. to a temperature of about
170° Centigrade in connection with a downwardly directed cooler for a sufficient
space of time to enable, in addition to the escaping water, benz-aldehyde to be
distilled off. The mixture is then treated with steam for the purpose of removing
the whole of the benz-aldehyde it contains, the extracting process being completed
by boiling the solution with the addition of carbon. After filtering, lactyl-para-
phenetidine is obtained in the condition of colourless prisms or crystals.
Dated this 9th day of October 1894.
JOHNSONS & WILLCOX,
47 Lincoln's Inn Fields, Agents.
An Improved Process for the Manufacture of Lactyl-p-phenetidine.
I, JAMES YATE JOHNSON, of 47 Lincoln's Inn Fields, in the County of
London, Gentleman, do hereby declare the nature of this invention (which has
been communicated to me from abroad by C. F. Boehringer and Sochne of
Waldhof near Mannheim in the Empire of Germany) and in what manner the
same is to be performed; to be particularly described and ascertained in and by
the following statement:-
It is a well known fact that benzyliden compounds of primary aromatic amines
will readily decompose under the action of diluted mineral acids, whereas they will
not do so under the action of concentrated sulphuric acid or under the influence of
acetic acid.
My foreign correspondents have found that lactic acid also, when raised to a
high temperature, is capable of decomposing benzyliden-para-phenetidine, at the
same time producing lactyl-para-phenetidine.

page_text: The following is an example of the manner in which this invention can be carried
into practical effect but I do not limit myself to the precise details.
22-5 parts by weight of benzyliden-para-phenetidine are heated together with
12 parts by weight of lactic acid at 75 per cent. to à temperature of or about
170° Centigrade in an open vessel or chamber (in connection with a downwardly
directed cooler) for a sufficient space of time to enable, in addition to the escaping
water, benz-aldehyde to be distilled off. The mixture is then treated with steam
for the purpose of removing the whole of the benz-aldehyde it contains, the
extracting process, being completed by boiling the solution with the addition of
carbon. After filtering, lactyl-para-phenetidine is obtained in the condition of
colourless prisms or crystals.
וי
:
Having now particularly described and ascertained the nature of this inven
tion, and in what manner the same is to be performed, I declare that what I
claim is:
T.
The manufacture of lactyl-para-phenotidine by heating benzyliden-para-phene-
tidine in the presence of lactic acid and with the employment of a high temperature
substantially as bereinbefore described.
Dated this oy oy
JOHNSONS & WILLCOX,
47, Lincoln's Inn Fields, London, W.C., Agents for the Applicant.