Method of Producing the same.
Year: 1886

page_text: Method of Producing the same.
We, CONSTANTIN FAHLBERG, doctor of philosophy, residing in New York,
United States of America, and ADOLPH LIST, doctor of philosophy, residing in
Leipsic, Kingdom of Saxony, German Empire, do hereby declare the nature of
this invention to be as follows:-
The object of our invention is to render less disagreeable the taste of various
organic alkaloids used as medicines, such as quinine, cinchonine, strychnine,
morphine and others, and the invention consists in combining the said alkaloids
with saccharine, a sweet substance, the preparation of which is described in the
specification of our British letters patent No. 6626, A.D. 1885, and the scientific
name whereof is anhydro-orthosulphamine-benzoic acid.
For this purpose saccharine is dissolved in water or alkohol, and the alkaloid is
added to the solution. A compound of the alkaloid with the saccharine, having
the chemical character of a salt, is thus obtained which may be separated out from
the solution, and in which the particular taste of the alkaloid is far less prominent
than in other salts of the same.

page_text: Method of Producing the same.
We,
CONSTANTIN FAHLBERG, doctor of philosophy, residing in New York,
United States of America, and ADOLPH LIST, doctor of philosophy, residing in
Leipsic, Kingdom of Saxony, German Empire, do hereby declare the nature of
this invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following specification :-
The object of our invention is to render less disagreeable the taste of various
organic alkaloids used as medicines, such as quinine, cinchonine, strychnine,
morphine and others, and the invention consists in combining the said alkaloids
with saccharine, a sweet substance the preparation of which is described in the
specification of our British letters patent No. 6626 A.D. 1885, and the scientific
name whereof is anhydro-orthosulphamine-benzoic acid.
For this purpose saccharine is dissolved in water or alkohol, and the solution is
neutralized by the alkaloid to be subjected to the treatment. A compound of the
alkaloid with the saccharine is thus formed, which may be separated out from
the solution in amorphous or in crystalline state, and in which the particular taste
of the alkaloid is far less prominent than in the sulphate or the hydrochlorate of
the same.
If saccharine is added in excess to the solution of the alkaloid prepared as
described, an acid salt is formed, which may also be easily obtained in crystalline
state, and which possesses still less than the neutral salt the taste of the pure
alkaloid.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, we declare that what we
claim is:
.
1. The process of producing neutral or acid compounds of organic alkaloids
with saccharine by dissolving the alkaloid in water or alkohol, and by adding to
the solution saccharine, i.e. anhydro-orthosulphamine-benzoic acid in such quantity
as either to neutralize the solution or to render it acid, and in separating out the
salt formed by the combination of the alkaloid with the saccharine, substantially
as and for the purpose described.
2. The product obtained by adding saccharine to an aqueous or alkoholic
solution of an organic alkaloid and separating out the salt formed thereby, the
said product possessing the property herein before specified.
Dated this twentieth day of August 1886.