Improvements in the Manufacture and Production of Pharmaceutical Compounds.
Year: 1892

page_text: Date of Application, 22nd Feb., 1892
Complete Specification Left, 21st Nov., 1892-Accepted, 31st Dec., 1892
PROVISIONAL SPECIFICATION.
Improvements in the Manufacture and Production of Pharmaceutical
Compounds.
I, BENJAMIN WILLCOX of 47 Lincoln's Inn Fields, in the County of Middlesex
Patent Agent do hereby declare the nature of this invention (which has been com-
municated to me from abroad by Farbenfabriken vormals Friedrich Bayer & Com-
pany of Elberfeld in the Empire of Germany) to be as follows:-
This invention relates to a new process for producing the acetylamidophenylester
of salicylic acid.
My foreign correspondents have found that the acetyl-para-amido-phenol
described by Morse in the Berichte der Deutschen chemischen Gesellschaft
Volume XI page 232 can be employed for producing the said medical compound
by allowing acetyl-para-amido-phenol to react on salicylic acid in the presence of
suitable condensing reagents the acetyl-amido-phenylester of salicylic acid being
formed in one single process and according to the following equation.
J. H. JOHNSON & Co.,
47, Lincoln's Inn Fields, London, W.C., Agents.

page_text: COMPLETE SPECIFICATION.
Improvements in the Manufacture and Production of Pharmaceutical
Compounds.
I BENJAMIN WILLCOX of 47 Lincoln's Inn Fields in the County of Middlesex
Patent Agent do hereby declare the nature of this invention (which has been
communicated to me from abroad by Farbenfabriken vorm. Friedrich Bayer & Co.
of Elberfeld in the Empire of Germany) and in what manner the same is to be
performed to be particularly described and ascertained in and by the following
.statement :-
This invention relates to a new process for producing the acetyl-amido-phenylic
salt of salicylic acid or analogous hydroxycarboxy acids described in the Specifica-
tion of Letters Patent No. 11833 granted to me and dated 11th July 1891.
My foreign correspondents have found that instead of starting from the nitro-
phenylic salt of salicylic acid or analogous hydroxycarboxy acids the acetyl-para-
amido-phenol (described by Morse in the Berichte der Deutschen chemischen
Gesellschaft Volume XI, page 232) can be employed for producing the said medical
compound by allowing acetyl-para-amido-phenol to act on salicylic acid or analogous
hydroxycarboxy acids in the presence of suitable condensing agents. For instance,
the production of the acetyl-amido-phenylic salt of salicylic acid, which may be
effected in a single operation takes place according to the following equation

page_text: If in the foregoing example the corresponding quantities of analogous hydroxy-
carboxy acids such as ortho-, meta- or para-cresol carboxy acid or the like, be
employed in place of salicylic acid the action proceeds in an analogous manner,
the acetyl-amido-phenylic salts of cresotinic acids or analogous hydroxycarboxy
acids which are defined in the aforesaid Specification of Letters Patent No. 11833
of 1891 being formed.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I
claim is :-
The process for producing the acetyl-amido-phenylic salt of salicylic acid, ortho-
cresol-carboxy acid, meta-cresol-carboxy acid and para-cresol-carboxy acid by
acting with acetyl-amido-phenol on salicylic acid, ortho-cresol-carboxy acid,
meta-cresol-carboxy acid or para-cresol-carboxy acid in the presence of
phosphous oxychloride or other condensing agents capable of producing the same
effect.
101 1
LNbox 1902