Manufacture of Hydroxyphenacetine-salicylate.
Year: 1895

page_text: Date of Application, 21st Dec., 1895
Complete Specification Left, 21st Sept., 1896-Accepted, 24th Oct.,
1896
PROVISIONAL SPECIFICATION.
[Communicated from abroad by THE FARBWERKE, vormals MEISTER LUCIUS
AND BRUNING, of Hoechst a/ Main, in the Empire of Germany, Chemical
Manufacturers.]
Manufacture of Hydroxyphenacetine-salicylate.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention to be as follows :-
:-
By the action of salicylic acid upon bromphenacetine or chlorphenacetine (which
are obtained by treating p-acetylamidophenol with ethylenebromide or ethylene-
chloride) a new compound is obtained having properties which render it suitable for-
medicinal purposes.
Hydroxyphenacetine-salicylate is prepared as follows:
1.6 kilos. of sodium salicylate are intimately mixed with 2 kilos. of chlorphen-
acetine, and the mixture is heated about half an hour at 170° to 180° C. in an
oilbath; the resulting melt is broken up and extracted with boiling water.
The insoluble residue is crystallised out of dilute alcohol to which animal
charcoal is added. Hydroxyphenacetine-salicylate separates out in the form of
shining lamina; it is not easily soluble in water, but easily soluble in alcohol; it
melts at 132° to 134° C.
By treating bromphenacetine with sodium salicylate in the same way the same
hydroxyphenacetine salicylate is obtained, according to the following equation:
NH сосн
ZOH
Dated 118 41st day of December 1095.
ABEL & IMRAY,
Agents for the Applicant..
COMPLETE SPECIFICATION.
Manufacture of Hydroxyphenacetine-salicylate.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement :-
By the action of salicylic acid upon bromphenacetine or chlorphenacetine (which
Manufacture of Hydroxyphenacetine-salicylate.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement :-
By the action of salicylic acid upon bromphenacetine or chlorphenacetine (which

page_text: are obtained by treating p-acetylamidophenol with ethylenebromide or ethylene-
chloride) a new compound is obtained having properties which render it suitable for
medicinal purposes.
Hydroxyphenacetine-salicylate is prepared as follows:-
1-6 kilos. of sodium salicylate are intimately mixed with 2 kilos. of chlorphen-
acetine, and the mixture is heated about half an hour at 170° to 180° C. in an
oilbath; the resulting melt is broken up and extracted with boiling water.
The insoluble residue is crystallised out of dilute alcohol to which animal
charcoal is added. Hydroxyphenacetine-salicylate separates out in the form of
shining lamine; it is not easily soluble in water, but easily soluble in alcohol; it
melts at 132° to 134° C.
By treating bromphenacetine with sodium salicylate in the same way the same
hydroxyphenacetine salicylate is obtained, according to the following equation:
employed.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed I declare that what I
claim is:-
1. The herein described manufacture of hydroxyphenacetine-salicylate by heating
chlorphenacetine or bromphenacetine with sodium or other salicylates.
2. The new product hydroxyphenacetine salicylate produced as already set
forth.
ABEL & IMRAY,
Agents for the Applicant.