Improvements in the Manufacture of Medicinal Pastilles.
Year: 1897

page_text: Date of Application, 5th Mar., 1897-Accepted, 22nd May, 1897
COMPLETE SPECIFICATION.
Improvements in the Manufacture of Medicinal Pastilles.
I, JOSEPH WERTHEIM of the Firm of Dr. Hofmann Nachfolger, Chemical
Works, Meerane, in the Kingdom of Saxony, Manufacturer, do hereby declare the
nature of this invention and in what manner the same is to be performed to be
particularly described and ascertained in and by the following statement :-
The modern science of therapeutics holds the firm opinion that in healing
internal diseases it is above all desirable to render the whole organism or the
several organs of the body capable of resisting those influences whose injurious
action is the cause of the disease in question. In view of the fact that tubercle
bacilli are not able to exert their destructive action so long as the bronchial
glands of man are fully operative, and that also in a body which is infected with
tubercle bacilli the commencement of tuberculosis of the lungs (consumption) is
coincident with the period of cessation of the work or action of the bronchial
glands, there is the possibility of healing tuberculosis of the lungs by supplying.
the human body with substances or materials which act as a substitute for the
inoperative bronchial glands and which are adapted to constitute a perfect.
equivalent for the action of the bronchial glands. A substance of this nature
is to be found in "glandul" which is the active constituent of the bronchial.
glands.
The present invention now relates to a process for converting “glandul” into
a form such that it can be employed for therapeutical purposes. For this purpose-
bronchial glands (preferably those of sheep, because sheep are almost proof against.
tuberculosis) are freed from fat and comminuted, whilst avoiding any loss of
juice, and are extracted at the ordinary temperature by means of water or alcohol..
The active substance contained in the solvents viz. the "glandul," is precipitated
from the said solvents by means of acids or alkalies. Since the auxiliary con-
stituents of the glands have no injurious action, the properly cleaned and comminuted
glands may also be treated direct after having been dried in a vacuum at a low
temperature. The product obtained by drying the extract or the glands is.
pulverised, mixed with milk-sugar and compressed into the form of tabloids or
tablets, such that each tabloid or tablet weighs about 0-250 grammes and.
corresponds to 0.250 grammes of fresh bronchial glands.
Having now particularly described and ascertained the nature of my said inven-.
tion and in what manner the same is to be performed, I declare that what I
claim is :-
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(1.) A process for the manufacture of "glandul" pastilles according to which
glandul alone, or in combination with the auxiliary constituents of the glands.
is mixed with milk-sugar and compressed into tabloids or tablets, as set forth.
(2.) A mode of carrying out the process specified in Claim 1, consisting in.
extracting bronchial glands, preferably those of sheep, by means of water or
alcohol, precipitating the active substance in the form of "glandul" by means of
acids. or alkalies from the extract, washing and drying the same, and then mixing
the product either alone or with the auxiliary constituents of the glands with.
milk-sugar, and compressing the same into tabloids or tablets, as set forth.
(3.) A mode of carrying out the process specified in the first claim consisting in

page_text: drying in a vacuum at a low temperature bronchial glands-preferably of sheep-
after having been properly cleaned, pulverizing or comminuting the product,
mixing the same with milk-sugar and compressing the same into tabloids or tablets,
as set forth.
Dated this 5th day of March 1897.
ROBERT E. PHILLIPS, Assoc. M. Inst. C.E., M.I. Mech. E.,
Consulting Engineer and Patent Agent,
70, Chancery Lane, London, W.C., Associate Agent.