AN IMPROVED MODE OF PREPARING CERTAIN ORGANIC BASES FCE PRODUCING COLOURING MATTERS
Year: 1870

page_text: LETTERS PATENT to Charles Bardy and Lucien Dusart, of Boulevard
de Strasbourg, No. 23, Paris, Chemists, for the Invention of "AN
IMPROVED MODE OF PREPARING CERTAIN ORGANIC BASES FCE PRODUCING
COLOURING MATTERS."
Sealed the 10th September 1970, and dated the 22nd April 1870.
PROVISIONAL SPECIFICATION lift by the said Charles Bardy and
Lucien Dusart at the Office of the Commissioners of Patents, with
their Petition, on the 22nd April 1870.
We, CHARLES BARDY and LUCIEN DUSART, of Boulevard de Stras-
bourg, No. 23, Paris, Chemists, do hereby declare the nature of the
said Invention for "AN IMPROVED MODE OF PREPARING CERTAIN ORGANIC
BASES FOR PRODUCING COLOURING MATTERS," to be as follows :-
This improved process is dependent on the property possessed by the
combinations of polybasic acids with the phenoles (more particularly
the sulphuric and phosphoric acids) of reacting upon alkaloids, in
combining therewith and producing new alkaloids comprising the
primitive alkaloid augmented by the radical of the phenole employed.
It is by thus reacting by means of a mineral or organic sulphophenate
CHIO SO SO MO, upon aniline that diphenylamine is obtained, C¹² 11³

page_text: O SO³ SO³ MO+C"H'N=C"H" N HO SO³+SO³ MO. Also by reacting
by means of a sulphophenate upon naphtylamine, phenylnaphtylamine is
obtained; by means of a sulphonaptolate (napthtalic phenole) and aniline,
naphtylaniline is obtained; by means of a sulphonaphtolate and naphty-
lamine, dinaphtylamine is obtained. This kind of reaction is applicable
to all alkaloids and to all the phenoles which are readily obtained by
known scientific methods. It is therefore a process susceptible of being
greatly generalized allowing the attainment at will of a great number
of new alkaloids, which offer, in addition the advantage of presenting
cases of varied isomerism, as the cases above cited-will-prove,-and-of
which it is possible to determine in advance the molecular grouping,
which for the purpose of the preparation of colouring matters is of
considerable interest. The mode of operating is exceedingly simple, it
consists in heating the combination of phenoles with acids in the
presence of an excess of the alkaloid that is desired to enter into reaction
either under pressure when the alkaloid employed possesses a certain
degree of volatility, or at the ordinary pressure when it is less volatile
or when it possesses powerful affinities. Thus, the sulphophenate reacts
upon aniline giving diphenylamine at a temperature of from 428° to
446° Fahrenheit, and the sulphonaphtolate reacts upon the naphtylamine
at a temperature of from 284° to 302° Fahrenheit. The temperature
may therefore vary for every substance made to enter into reaction. It
has been above stated that the alkaloid should by preference be in excess
in order to obtain a greater quantity of the new alkaloids; these sub-
stances are however produced, whatever may be the proportions
employed, either of the alkaloid or of the combination of the acids
with the phenoles.
SPECIFICATION in pursuance of the conditions of the Letters Patent,
filed by the said Charles Bardy and Lucien Dusart in the Great
Seal Patent Office on the 20th September 1870.
'TO ALL TO WHOM THESE PRESENTS SHALL COME, we, CHARLES
BARDY and LUCIEN DUSART, of Boulevard de Strasbourg, No. 23, Paris,
Chemists, send greeting.
WHEREAS Her most Excellent Majesty Queen Victoria, by Her
Letters Patent, bearing date the Twenty-second day of April, in the
year of our Lord One thousand eight hundred and seventy, in the

page_text: thirty-third year of Her reign, did, for Herself, Her heirs and suc-
cessors, give and grant unto us, the said Charles Bardy and Lucien
Dusart, Her special licence that we, the said Charles Bardy and Lucien
Dusart, our executors, administrators, and assigns, or such others as
wc, the said Charles Bardy and Lucien Dusart, our executors, adminis-
trators, and assigns, should at any time agree with, and no others, from
time to time and at all times thereafter during the term therein ex-
pressed, should and lawfully might make, use, exercise, and vend, within
the United Kingdom of Great Britain and Ireland, the Channel Islands,
and Isle of Man, an Invention for "Ax IMPROVED MODE OF PREPARING
CERTAIN ORGANIC BASES FOR PRODUCING COLOURING MATTERS," upon the
condition (amongst others) that we, the said Charles Bardy and Lucien
Dusart, our executors or administrators, by an instrument in writing
under our or their hands and scals, or under the hand and seal of
one of us or them, should particularly describe and ascertain the nature
of the said Invention, and in what manner the same was to be per-
formed, and cause the same to be filed in the Great Seal Patent Office
within six calendar months next and immediately after the date of the
said Letters Patent.
NOW KNOW YE, that we, the said Charles Bardy and Lucien Dusart,
do hereby declare the nature of the said Invention, and in what manner
the same is to be performed, to be particularly described and ascertained
in and by the following statement thereof, that is to say :-
This improved process is dependent on the property possessed by the
combinations of polybasic acids with the phenoles (more particularly
the sulphuric and phosphoric acids) of reacting upon alkaloids, in com-
bining therewith and producing new alkaloids comprising the primitive
alkaloid augmented by the radical of the phenole employed. It is by
thus reacting by means of a mineral or organic sulphophenate C¹ H³ O
SO³ SO MO, upon aniline that diphenylamine is obtained, C” H³ ○
SO' SO³MO+C" H³ N=C” H" N HO SO³+SO³MO. Also by reacting
by means of a sulphophenate upon naphtylamine, phenylnaphtylamine
is obtained; by means of a sulphonaphtolate (naphtalic phenole) and
aniline, naphtylaniline is obtained; by means of a sulphonaphtolate and
naphtylamine, dinaphtylamine is obtained. This kind of reaction is
applicable to all alkaloids and to all the phenoles which are readily
obtained by known scientific methods. It is therefore a process sus-
ceptible of being greatly generalized, allowing the attainment at will of
a great number of new alkaloids which offer in addition the advantage

page_text: of presenting cases of varied isomerism as the cases above cited will
prove, and of which it is possible to determine in advance the molecular
grouping, which for the purpose of the preparation of colouring matter
is of considerable interest. The mode of operating is exceedingly simply.
It consists in heating thic combination of phenoles with acids in the
presence of an excess of the alkaloid that is desired to enter into
reaction, either under pressure when the alkaloid employed possesses a
certain degree of volatility, or at the ordinary pressure when it is less
volatile or when it possesses powerful affinities. Thus the sulphophenate
reacts upon aniline, giving diphenylamine at a temperature of from-428°
to 446° Fahrenheit, and the sulphonaplitolate reacts upon the naphty-
lamine at a temperature of from 284° to 302° Fahrenheit. The tem-
perature may therefore vary for every substance made to enter into
reaction. It has been above stated that the alkaloid should by preference
be in excess in order to obtain a greater quantity of the new alkaloids;
these substances arc, however, produced whatever may be the proportions
employed, either of the alkaloid or of the combination of the acids with
the phenoles.
Having thus described the nature of our Invention and in what
manner the same is to be performed, what we claim is, the above
described preparation of alkaloids with multiple or conjugated radicals
by reacting upon the alkaloids by means of substances obtained by the
action of polybasic acids upon phenoles of whatever origin.
In witness whereof, wc, the said Charles Bardy and Lucien Dusart,
have hereunto set our hands and seals, this Sixteenth day of
September, in the year of our Lord One thousand eight hundred
and seventy.
Witness,
C. LAFOND,
Civil Engineer,
(L.S.)
CH. BARDY.
LUCIEN DUSART. (L.s.)
23, Boulevart de Strasbourg,
Paris.