Improvements in Digestive Medical Compounds and in the Preparation of the same.
Year: 1889

page_text: Date of Application, 15th Oct., 1889-Accepted, 30th Nov., 1859
JUMI LIE
Improvements in Digestive Medical Compounds and in the
Preparation of the same.
I, JOHN CARNRICK, of 447 Greenwich Street, in the City and State of New York,
United States of America, Manufacturing Chemist, do hereby declare the nature of
this invention and in what manner the same is to be performed, to be particu-
larly described and ascertained in and by the following statement :-
This invention relates to a digestive medical compound adapted particularly for
causing the digestion and absorption of fatty matters, to aid in converting starchy
matter into an assimilable condition, and to promote the digestion of albuminous
substances, and to the process of preparing the same.
The object of the invention is to provide an improved method of preparing the
constituents and uniting them to form a digestive compound for the purpose above
mentioned.
More particularly, my object is to prepare, in a more efficient manner than hereto-
fore practised, powdered pancreatine ;-a strong watery solution or infusion thereof;
and a preparation of purified bile suitable for admixture with the pancreatine, or a
solution thereof, to form liquid or powdered digestive compounds. To the watery
solution or infusion of pancreatine, there is added suitable proportions of purified
bile, an alcoholic preservative, sugar and flavoring oils or extracts, to form an
agreeable liquid compound; and to the powdered pancreatine, there is added
powdered purified bile, and the mixture is enclosed in capsules, or is formed with a
suitable excipient into pills, which are coated with a substance adapted to resist
the acid action of the fluids of the stomach, but which will be readily dissolved in the
alkaline secretions which flow into the intestinal canal. These compounds can be
readily taken by persons in delicate health, or in a debilitated, emaciated condition,
and by those suffering from constipation and wasting diseases, with the satisfactory
result of producing a vigorous healthy tone of the digestive organs, and especially of
the alimentary canal,-relieving constipation, and causing a rapid increase of fat and
flesh in the person using it.
It has been ascertained by experimental research that, separately, neither the bile
nor pancreatic juice are capable of effecting the complete digestion and absorption of
the fatty substances; but they together act to cause fine division and complete
digestion of fatty substances, and promote their assimilation. The pancreatic extract
digests about 40% of fat, while the prepared bile digests about 60% of fat, when
they are administered together in suitable quantity. It has also been ascertained
that bile possesses a well-marked antifermentative property.
The established properties and beneficial action of the bile indicate that it is an
important remedial agent when properly combined and administered.
The compound of pancreatine, or watery extract of pancreas and bile, as prepared
in accordance with my invention, not only causes the digestion and absorption of
fats, but materially aids the digestion of albuminous substances, and also serves to
convert starchy matter into an assimilable condition.
In order to prepare my digestive compound the fresh sweet-breads (pancreas) in
suitable quantity, are first carefully dressed, by removing with a knife all the
adhering fat; they are then chopped fine in a chopping machine, and the finely
comminuted mass is then digested in alcohol of 95% strength, in the proportion of
about forty-five pounds of pancreas to three gallons of alcohol, for a period of about
ten hours, for the purpose of loosening, softening, and partially dissolving the fatty
matter entangled in its tissue, preparatory to its removal. The alcohol also prevents
pancreatic digestion of the fatty matter contained in the parenchyma during
manipulation of the raw material. The period of maceration having been completed,

page_text: the mass of pancreas is well pressed to squeeze out the moisture and fat, after which
it is carefully dried in the drying chamber. When well dried, it is reduced to a fine
powder, preferably in a roller mill. It is quite important to remove the fatty matter
entangled in the parenchyma of the pancreas, as above described, in order to present
the digestive principle in the most active and favorable condition. This operation
of removing the fatty matter from the parenchyma of the pancreas, and leaving only
the fibrous tissue containing the active principle of digestive ferment, constitutes a
part of the invention in my improved process. This dried powder, prepared from
the pancreas as above described, constitutes my pancreatine, and is in proper condition
to mix with prepared bile and a suitable excipient to form pills. Two and a half
ounces of dry powdered pancreatine represents the substance of twenty-five fresh
sweet-breads.
In order to prepare the bile for use in my compound, it is first removed from the
gall sack, and then mixed with a suitable proportion of alcohol; and allowed to stand
about twenty-four hours for the mucous and other impurities to settle, after which the
liquid is decanted. This liquid is then filtered through animal or wood charcoal to
further purify it, after which it is evaporated to dryness. This purified bile may be
used directly in the dry powdered condition in the manufacture of pills.
In order to make my liquid compound, the powdered pancreatine, prepared as
above described, is macerated about twenty-four hours in water, in about the
proportion of two and a half ounces of the dry powder to each gallon of the finished
liquid, and the mass is agitated and thoroughly beaten till the pancreatine is reduced
to a fine pulp and its active digestive principle is fully diffused through and
incorporated with the water, forming an active watery solution or infusion of
pancreatine. The exhausted fibrous matter and connective tissue are then removed
by filtration, or are allowed to settle and the clear liquid decanted. The operation of
forming the watery pancreatic solution or infusion, is an important step in my process.
Having prepared my watery solution of pancreatine, I take for each gallon of liquid
to be used:

page_text: Having now particularly described and ascertained the nature of my said inven-
tion, and in what manner the same is to be performed, I declare that what I
claim is :-
1. The process of preparing a compound for causing the digestion and absorption
of fats, albuminous and starchy matters, which consists in treating pancreas or sweet-
breads, with alcohol and pressure to remove the fatty matter, then agitating the
resulting pancreatine in water to form a watery pancreatic solution; purifying bile
by treating it with alcohol, filtering through charcoal and drying, then mixing the
bile with the watery solution of pancreas and a suitable preservative
2. In the manufacture of a digestive compound, the herein described method
of preparing the pancreatine used therein, which consists in removing the fatty
matter from the pancreas or sweet-breads, first by mechanical means, then by
macerating the comminuted pancreas in alcohol, then subjecting it to pressure and
drying to preserve it; and to form a watery solution; agitating the pancreatine in
water to impregnate the water with pancreatic extract.
3. A digestive compound adapted to cause the digestion and absorption of fats,
containing either powdered pancreatine or a fluid extract thereof, and bile mixed in
suitable proportions.
4. A liquid compound adapted to cause the digestion and absorption of fats,
containing suitable proportions of a fluid extract of pancreas, purified bile, an alcoholic
preservative, sugar and suitable flavoring substances.
5. A powdered, digestive compound adapted to cause the digestion of fats,
albuminous substances, and starchy matter, composed of powdered pancreatine, and
bile, enclosed in capsules or formed into pills and having a coating adapted to resist
the acid action of fluids in the stomach, but which will be dissolved in the alkaline
secretions which flow into the intestinal canal.
Dated this 4th day of October 1880
NEWTON & SON,
Agents for the Applicant.