Improvements in and connected with the Preparation of Mineral and Vegetable Oils for Pharmaceutical, Veterinary, Technical, and other Purposes.
Year: 1897

page_text: Date of Application, 1st Feb, 1897
Complete Specification Left, 1st Nov., 1897--Accepted, 1st Feb.,
1898
PROVISIONAL SPECIFICATION.
Improvements in and connected with the Preparation of Mineral and
Vegetable Oils for Pharmaceutical, Veterinary, Technical, and
other Purposes.
I, WILLIAM EDWARD PEARSON, of No. 8, Cremon, Hamburg, in the German
Empire, Manufacturing Chemist, do hereby declare the nature of this invention
to be as follows:-
The process forming the subject of the present invention has for its object to
prepare mineral and vegetable oils in such a manner, that substances which are
otherwise insoluble, are made soluble by merely being shaken in the prepared
oils, without pressure and heat. The oils prepared according to it can be made
use of for industrial purposes, for instance, as lubricants with or without the
addition of water.
For medical purposes, these prepared mineral oils have as a liniment the special
and novel advantage, that the physician is enabled to order each time the necessary
amount of medicine already clearly dissolved therein, as the chemist can immediately
dispense such preparations according to the prescription by merely mixing them
at the temperature of the room.
Oils
To produce these oils different commercial oils are necessary as residues of
petroleum, vegetable oils as cotton seed oil, castor oil, resinous oil, etc. These
are mixed together in certain quantities according to their nature. Oils containing
oleic acid are necessary, but the quantity of oleic acid need not exceed 20%-
containing resinous matter should not exceed 10%. The mixture is then carefully
washed and dried by suitable means, i.e., by stirring while warm but the tempera-
ture must not exceed 120° C. The oils so treated should be allowed free contact
with air whilst stirring. After this manipulation which is to be continued until
not more than 5% of moisture is left an alcoholic solution of strong basis not
exceeding 10% is subsequently added and allowed to cool off. The mixture so
obtained must be clear and transparent.
In these so prepared oils, substances which are otherwise insoluble can be dis-
solved by merely shaking without pressure or heat. These preparations differ
from those hitherto prepared from vaseline as they are not artificially prepared
by means of pure oxygen, nor is pressure used, nor is it necessary to introduce
drugs during the preparation.

page_text: Improvements in and connected with the Preparation of Mineral and
Vegetable Oils for Pharmaceutical, Veterinary, Technical, and
other Purposes.
:
93
I, WILLIAM EDWARD PEARSON, of No. 8, Cremon, Hamburg, in the German
Empire, Manufacturing Chemist, do hereby declare the nature of this invention
and in what manner the same is to be performed, to be particularly described and
ascertained in and by the following statement:
The object of the present invention is to prepare mineral and vegetable oils in
such a manner that drugs, chemicals, and other substances which are otherwise
insoluble in oil are made soluble on being mixed and shaken with these..prepared
oils, and without using either pressure or heat during the mixing, process.. Dils
prepared in the following manner may be used as liniments or .lubricants, in the
latter case they can be used with the addition of water.
To manufacture these oils, any ordinary commercial oils may be_einployed,
such as the residues of petroleum, vegetable oils, such as cotton seed oil or castor
oil, resinous oils, etc.
These oils are mixed together in certain quantities according to their nature,.
and to them are added oils (those of the same specific gravity preferably) contain-
ing oleic acid but. the proportion of the said acid need not be more than 20%-
Oils containing resinous matter, should not exceed 10%. These oils are deprived
of all impurities by the aid of sulphuric acid, not exceeding 1% every trace of
which is afterwards removed by washing; to the. water employed a small propor-
tion of caustic soda about 1% should be added. The oils are then dried by any
suitable means, preferably by heat and active stirring. During the warming
process the temperature should not exceed 120° C., and while under treatment the
oils should be exposed to the air as much as possible. Air may be artificially
introduced if it is desired to hasten the process. Drying should be continued until
not more than 5% of moisture remains; after. which an alcoholic solution of
strong basis, but not exceeding 10%, is added at a temperature not exceeding 80°.G.,
and then allowed to cool off.
The compound so formed should be clear and transparent, and should not solidify
on cooling These oils are not soluble in water, but form an emulsion. When
used as a liniment and brought into contact with the perspiration of the body,
they are very readily absorbed through the skin, taking with them any drug or
chemical or other substance with which they may be incorporated. For medical
purposes oils prepared in this manner have therefore this especial and novel
recommendation, that a physician or veterinary is, by their means enabled to
ordinate any given quantity of any drug, chemical, or other substance which will
be dissolved completely in these oils, whereby the drugs are more easily absorbed
into the body, or given inwardly more effectively than by any other means, and
therefore smaller quantities could be used to attain the same effects. Drugs or
chemicals that it is desired to dissolve are mixed with this compound in various
proportions according to the solubility of the articles, and without increasing
the temperature of the oils, but simply by mixing and shaking in the ordinary
way.
The compound then forms a clear substance, which emulsifies on being
mixed with water.
It must be clearly understood that I do not confine myself to any particular
mineral or vegetable oil neither to any specific proportions of the oils or other

page_text: ingredients employed, for obviously these must both depend upon the require-
ments of each individual case, but the following is an instance, viz:-
04
-
In the above instance the gum camphor is the substance which would not be
dissolved without the presence of the alcohol, and the olive oil that which provides
the oleic acid. The proportion of mustard seed oil would vary according to the
strength desired to be given to the final compound.
Drugs or chemicals which can be dissolved in these prepared oils are very
numerous and in themselves form no part of this invention, but as a guide to
what kind of substances are referred to the following are some of the most useful
and general to employ, viz.:-perfume gums, soaps for shampooing, and other
purposes, iodoform, quicksilver, iodine, turpentine, camphor, salicylic acid, menthol,
creosote, and many other drugs and substances used in pharmacy.
For lubricating purposes a given quantity of these oils to which 25% of
stearine is added can be mixed with water in the proportion of one part oil to five
parts water. They then form a soapy substance which can be used for lubri-
cating machinery, etc.
The advantages of its employment are that when the parts become heated the
water contained in the compound evaporates in the form of steam, thus cooling
off the machinery again immediately, and preventing the slightest accumulation
of heat.
Having now particularly described and ascertained the nature of my said
invention, and in what manner the same is to be performed, I declare that what
I claim is:-
1. The process of rendering mineral and vegetable oils capable of dissolving
certain substances which are otherwise insoluble in oil by mixing such oils with
an oil or oils containing oleic acid by washing with acid, which acid is subsequently
removed by alkaline water and by adding to this mixture a small portion of an
alcoholic solution of strong basis, substantially as and for the purpose set forth.
2. The compound consisting of mineral or vegetable oils and an oil or oils
containing oleic acid or resinous matter, combined with an alcoholic solution of
strong basis in such proportions as to render soluble such substances which are
per se insoluble, such as herein referred to, substantially as set forth.
1002
PHILLIPS & LEIGH,
No. 22, Southampton Buildings, Chancery Lane, London, W.C.,
Agents for the Applicant.