An Improvement in Preparations for Disguising Unpalatable Medicines, and Process of Preparing and Using the same.
Year: 1899

page_text: Date of Application, 17th Jan., 1899
Complete Specification Left, 10th Oct., 1899-Accepted, 11th Nov., 1899
An Improvement in Preparations for Disguising Unpalatable
Medicines, and Process of Preparing and Using the same.
I, DANIEL FREDERICK DAVENPORT, of Americus, in the County of Sumter and
State of Georgia, United States of America, Druggist, do hereby declare the
nature of this invention to be as follows:
My invention relates to the composition of a solution or liquid for disguising
unpalatable medicines by rendering them slowly soluble in the saliva, so that
they shall be tasteless or practically so, and afterwards be more grateful and
readily retained by the stomach, to the process of preparing such disguising
solution or liquid, and to the process of rendering medicines which are repugnant
such for example as sulphate of quinia-palatable or practically tasteless, as
hereinafter described.
My improved disguising solution is composed of the following ingredients,
which are combined as stated:
Balsam of fir, refined
Shellac, refined,
Alcohol, 95 per cent.,
500 grains, troy.
2000 grains, troy.
12 fluid ounces.
Mix and allow balsam and shellac to dissolve, then add,
Olive oil, pure,
3 fluid ounces.
Shake well and allow solution to stand preferably for 24 hours agitating
frequently, after which, it will be ready for use.
This disguisant is adapted to render a number of unpalatable or nauseous drugs
or medicines palatable or practically tasteless, such as many alkaloids, glucosides
and their derivatives, for example sulphate of quinia, sulphate of morphia,
caffeine, salicin, aloes, pepper, and allied products.
For instance to make a preparation of sulphate of quinia which shall be palat-
able or practically tasteless, I proceed as follows.
Take of the sulphate, and thoroughly mix with the disguising liquid to form
a paste. Heat the latter for several hours at 212° F., stirring the mass thoroughly
at intervals of 30 minutes. The mass will then become hard and brittle, and,
being allowed to cool, may be easily broken up into small particles, preparatory
to grinding it in a mill to such degree of comminution that it will pass through
a sieve, No. 30 or No. 40 mesh preferred. After sifting, heat the product in
a vessel for 30 minutes at a temperature of 212° F., being careful to stir well
at intervals of 15 minutes. Remove from heater, allow to cool, and bottle for use.
Sulphate of morphia and allied products, also caffeine, salicin, aloes and pepper,
may be treated in substantially the same manner as sulphate of quinia, to render
them palatable.
I propose to use my disguising liquid to produce any powders, pills, tablets
or other forms of medicines put up in capsules or suspended in liquids.
I do not desire to limit myself to the use of alcohol since some other solvent,

page_text: ether for example, may be employed, and in general, I propose to use any other
ingredients in place of those named which may perform essentially the same
service.
Toted this 17th day of Tonuary 1800
A. M. & WM. CLARK,
Chartered Patent Agents, 53, Chancery Lane, London.
An Improvement in Preparations for Disguising Unpalatable
Medicines, and Process of Preparing and Using the same.
I, DANIEL FREDERICK DAVENPORT, of Americus, in the County of Sumter and
State of Georgia, United States of America, Druggist, do hereby declare the
nature of this invention and in what manner the same is to be performed, to
be particularly described and ascertained in and by the following statement:-
My invention relates to the composition of a solution or liquid for disguising
unpalatable medicines by rendering them slowly soluble in the saliva, so that
they shall be tasteless or practically so, and afterwards be more grateful and
readily retained by the stomach; to the process of preparing such disguising
solution or liquid, and to the process of rendering medicines which are repugnant
such for example as sulphate of quinia-palatable or practically tasteless; as
hereafter described.
My improved disguising solution is composed of the following ingredients,
which are combined as stated:,
Balsam of fir, refined
Shellac, refined,
-
Alcohol, 95 per cent.,
-
-
500 grains, troy.
2000 grains, troy.
12 fluid ounces.
Mix and allow balsam and shellac to dissolve, then add,
Olive oil, pure,
3 fluid ounces.
Shake well and allow solution to stand preferably for 24 hours agitating
frequently, after which it will be ready for use.
This disguisant is adapted to render a number of unpalatable or nauseous drugs
or medicines palatable or practically tasteless, such as many alkaloids, glucosides
and their derivatives; for example sulphate of quinia, sulphate of morphia,
caffeine, salicin, aloes, pepper, and allied products. For instance to make a
preparation of sulphate of quinia which shall be palatable or practically tasteless,
I proceed as follows:
Take of the sulphate, and thoroughly mix with the disguising liquid to form
a paste. Heat the latter for several hours at 212° F., stirring the mass thoroughly
at intervals of 30 minutes. The mass will then become hard and brittle, and,
being allowed to cool, may be easily broken up into small particles, preparatory
to grinding it in a mill to such degree of comminution that it will pass through
a sieve, No. 30 or No. 40-mesh preferred. After sifting, heat the product in
a vessel for 30 minutes at a temperature of 212° F., being careful to stir well
at intervals of 15 minutes. Remove from heater, allow to cool and bottle for use.
Sulphate of morphia and allied products, also caffeine, salicin, aloes and pepper,
may be treated in substantially the same manner as sulphate of quinia to render
them palatable.
I propose to use my disguising liquid to produce any powders, pills, tablets
or other forms of medicines put up in capsules or suspended in liquids.

page_text: I do not desire to limit myself to the use of alcohol since some other solvent,
ether for example, may be employed; and in general, propose to use any other
ingredients in place of those named which may perform essentially the same
service.
Having now particularly described and ascertained the nature of the said
invention and in what manner the same is to be performed, I declare that what
I claim is:
_
1. The improved preparation for disguising unpalatable medicines, the same
comprising balsam of fir, shellac, alcohol, and olive oil, substantially as specified.
2. The improved preparation for disguising unpalatable medicines, the sanie
comprising balsam of fir, 500 grains troy, shellac, 2000 grains troy, strong
alcohol, 12 fluid ounces, and olive oil, 3 fluid ounces, the same being intimately
mixed to form a liquid, as specified.
3. The improved process of producing a disguising solution for use in preparing
unpalatable medicines for consumption, which consists, first, in dissolving balsam
of fir and shellac in alcohol, in the presence of olive oil and mixing thoroughly,
then allowing the liquid to stand a due time, the proportions of the several
ingredients being preferably as hereinbefore specified.
4. The improved process of rendering an unpalatable drug or medicine practi-
cally tasteless, the same consisting in mixing with such medicines a liquid com-
posed of balsam of fir, shellac, alcohol, and olive oil, heating the pasty mass thus
formed, then allowing it to cool, reducing the same to small particles, and
reheating it, substantially as shown and described.
Natal this 10th day of October 1899
A. M. & WM. CLARK,
Chartered Patent Agents, 53, Chancery Lane, London.