Production of Therapeutic Substances from Quinic Acid and Hexa-methylene-tetramine.
Year: 1899

page_text: PROVISIONAL SPECIFICATION.
The Production of Therapeutic Substances from Quinic Acid and
Hexa-methylene-tetramine.
I, AUGUST ZIMMERMANN, of 9 & 10, St. Mary at Hill, in the City of London,
Merchant, do hereby declare the nature of this invention (which has been com-
municated to me from abroad by The Chemische Fabrik auf Actica vormals E.
Schering, of 170 and 171, Müllerstrasse, Berlin, in the Empire of Germany,)
to be as follows:-
It is known that hexa-methylene-tetramine possesses great therapeutic proper-
ties for example in cases of uric acid diathesis, cystitis and the like and also
that vegetable acids such as citric acid, and tartaric acid render great services in
gouty maladies. Latterly quinic acid has with advantage been substituted for
the hitherto usual vegetable acids, because larger individual doses of it can be
assimilated without prejudice to the system.
Quinic acid can however by reason of its acid character and hexa-methylene-
tetramine by reason of its basic character be permanently taken up by the
system in limited quantities only. The system rebels against permanently large
doses of the substances. in question.
According to this invention a stable salt like compound is formed from both
substances.
If both substances be combined with each other, the chemical actions
neutralize each other whilst their therapeutic action becomes materially increased.
The system can also without injury permanently endure larger doses of the
compound. A further considerable advantage of the new compound of hexa-
methylene-tetramine and quinic acid consists in that it has a pleasant salt like
taste whilst that of quinic acid alone is acid and that of hexa-methylene-tetramine
is unpleasantly sweet.
Stable salt like compounds of quinic acid and hexamethylene-tetramine can
be produced from these two substances either by intimately mixing molecular
quantities of hexa-methylene-tetramine and quinic acid or by the mutual reaction
of both substances in solution by known methods, and evaporating for example
in vacuo.
It is of course not necessary to take exactly molecular quantities of the com-
ponents; the acid or the base may be in excess.

page_text: The Production of Therapeutic Substances from Quinic Acid and
Hexa-methylene-tetramine.
I, AUGUST ZIMMERMANN, of 9 & 10, St. Mary at Hill, in the City of London,
Merchant, do hereby declare the nature of this invention (which has been com-
municated to me from abroad by The Chemische Fabrik auf Actien vormals E.
Schering, of 170 and 171, Müllerstrasse, Berlin, in the Empire of Germany,)
and in what manner the same is to be performed to be particularly described
and ascertained in and by the following statement:-
-
This invention relates to the production of salt like compounds of hexa-
methylene tetramine and quinic acid, which are extremely efficacious for thera-
peutic purposes.
Quinic acid by reason of its acid character and hexamethylene tetramine by
reason of its basic character can be taken up by the system in limited quan-
tities only. If however the two substances be combined together, the chemical
actions neutralize each other, whilst their therapeutic action becomes materially
increased. The system can also without injury permanently endure larger doses
of the compound. It is a further advantage that the compound has a pleasant
salt like taste whilst hexamethylene tetramine tastes unpleasantly sweet.
Salt like compounds of hexamethylene tetramine and quinic acid may be
produced by intimately mixing molecular quantities of both components together
or by the mutual reaction of both substances in solution of water, benzol, alcohol
or other suitable solvent by known methods for example by evaporating in vacuo
or at usual atmospheric pressure. The compounds are dry and stable.
It is of course not necessary to take exactly molecular quantities of the cour
ponents; the acid or the base may be in excess.
Clinical observation has shown that the combination of quinic acid and hexa-
methylene tetramine possesses special advantage and increases the action of the
hexamethylene tetramine on ammoniacal urine fermentation. A greater splitting
off of formic aldehyde takes place and thereby a greater disinfective action.
Further the formation of uric acid in the system is lessened which is of import-
ance in the case of uric acid diathesis.
By administration of the above named 'salt like compounds hippuric acid is
excreted with the urine.
Having now particularly described and ascertained the nature of my said
invention and in what manner the same is to be performed I declare that what
I claim is:-
1. The production of therapeutic substances from hexamethylene tetramine
and quinic acid in such a manner that quinic acid is combined with hexa-
methylene tetramine in a solid or dissolved form.
2. The herein described salt like compounds of quinic acid and hexamethylene
tetramine.