Year: 1888

page_text: A communication from abroad by LORETTA BARTON WELD, of Falmouth, in the
State of Massachusetts, United States of America, Gentlewoman.
I, PHILLIP MIDDLETON JUSTICE of 55 and 56 Chancery Lane, in the County of
Middlesex Fellow of the Institute of Patent Agents, do hereby declare the nature
of this invention and in what manner the same is to bo performed, to be particularly
described and ascertained in and by the following statement :-
The manufacture of hydrochlorate of quinine as heretofore practically carried on is
attended with difficulties, delays, and expense, which it is the object of the present
invention to obviate.
In carrying out the invention a sufficient quantity of sulphate of quinine is boiled
in alcohol with chloride of sodium or common salt. The boiling is continued for
about ten minutes and at the end of that time both salts will have become decomposed
and converted into hydrochlorato of quinine and sulphate of soda in solution. The
solution is then concentrated and cooled; when the sulphate of soda and any excess
of chloride of sodium will be precipitated, after which the alcohol is evaporated, when
the hydrochlorate will form in crystalline state.
The alcohol used is as free from water as possible, and it is best to use an excess of
chloride of sodium.
In actual process of manufacture one part of sulphate of quinine is used to four
parts of chloride of sodium and fifty parts more or less of alcohol.
By the means described the sulphate is effectually and completely converted into a
hydrochlorate, and the crystalline product thus formed is free from anything but a
trace of the other salt.
The boiling of the salts is performed either in a strong closed vessel under pressure,
or in a retort so that the vaporized alcohol may be collected and conducted to a worm
for condensation; the concentration of the solution is effected in like manner, if the
boiling in the first instance is effected in a closed vessel.
By this means the process is conducted with but little loss and is speedily effected,
while the various steps are simple operations, readily performed without the use of
acids and not requiring the constant careful and experienced manipulation required
in the ordinary process of manufacture.

page_text: It has also been found from practical tests that the hydrochlorate made as
described is more soluble than that resulting from the ordinary process of
manufacture.
It will be understood that the precise proportions given may be varied if
desired.
Having now particularly described and ascertained the nature of the said
invention, and in what manner the same is to be performed, as communicated to me by
my foreign correspondent, I declare that what I claim is:
1. The within described improvements in the manufacture of the hydrochlorate of
quinine, consisting in dissolving in boiling alcohol the sulphate of quinine with
chlorido of sodium, precipitating the sulphate of sodium and any excess of chloride of
sodium and then evaporating the alcohol, forming the hydrochlorate of quinine as
crystals, substantially as described.
2. In the manufacture of hydrochlorate of quinine, dissolving sulphate of quinine
and chloride of sodium in boiling alcohol, concentrating the solution until sulphato
of soda is precipitated, then separating the precipitate and evaporating, to deposit the
hydrochlorate of quinine in a crystallized form, substantially as described.
Dated this 11th day of March 1888