The Manufacture and Production of a New Compound of Iodol and Albumen.
Year: 1899

page_text: Date of Application, 11th Aug., 1899
Complete Specification Left, 7th May, 1900-Accepted, 23rd June, 1900
PROVISIONAL SPECIFICATION.
The Manufacture and Production of a New Compound of Iodol
and Albumen.
I, GEORGE WILLIAM JOHNSON, of 47, Lincoln's Inn Fields, in the County of
London, Patent Agent do hereby declare the nature of this invention (which
has been communicated to me from abroad by Kalle & Co., of Biebrich-on-Rhine,
in the German Empire) to be as follows:-
This invention relates to the preparation of odourless and tasteless compounds
of iodol (tetraiodopyrrol) with albumen, for use as medicine for internal appli-
cation, the said compounds containing the iodol in a chemically bound, or
absorbed condition, as the components of the said compounds cannot be sepa-
rated mechanically. The dissolved albuminous body may be brought, in the
presence of the iodol, to a state of coagulation. I illustrate the nature of the
invention by the following examples to which however the invention is not
limited.
EXAMPLE I.
100 grammes of pure white of egg are dissolved in 500 cubic centilitres of
water, and, to this solution a solution of 20 grammes of iodol, in 200 cubic
centilitres of soda lye, is added, superadding, immediately the quantity of
hydrochloric acid required for neutralization.
Coagulation will begin at once and become complete after active stirring for
a short time. The compound of iodol and albumen separates in flakes, is filtered,
thoroughly washed with water, and a little alcohol, and pressed and dried at
a moderate temperature. The powder obtained by disintegration, after drying,
is light yellow, and free from odour and taste; it is insoluble in water and
the other usual solvents and will only dissolve into a clear fluid upon being
heated continuously with diluted alkalies.
Instead of using the albumen of eggs, other albumens can be used such as
the albumen of blood, or milk, for example.
EXAMPLE II.
100 grammes of albumen are dissolved in 500 cubic centimetres of water
and mixed with 200 cubic centimetres of a five to six per cent. soda lye. The
mass immediately solidifies into a jelly which, when heated, will liquefy again.
As soon as liquefaction has set in there is added a solution of 20 grammes of
iodol in 100 cubic centimetres of five to six per cent. soda lye and 100 cubic
centimetres of water, and the mixture is neutralized with hydrochloric acid.
The product separates in coarse flakes. In other respects the method of pro-
cedure is the same as in Example I.
The compound obtained in accordance with Example II differs from that
obtained in accordance with Example I only in that it will, when heated, dis-
solve in alkaline liquors more readily and quickly. Besides the albumens
soluble in water, other albumens which, though insoluble in water, will dis-

page_text: solve in acids, or alkalies, and may be separated from these solutions again
by neutralization, may be employed for the purposes of this invention.
The proportions given in the foregoing examples for the concentration of the
novel product may be widely varied.
Dated thi 1141
عمل
f Lument
1800
JOHNSONS & WILLCOX,
47, Lincoln's Inn Fields, London, W.C., Agents.
The Manufacture and Production of a New Compound of Iodol
and Albumen.
I, GEORGE WILLIAM JOHNSON, of 47, Lincoln's Inn Fields, in the County of
London, Patent Agent do hereby declare the nature of this invention (which
has been communicated to me, from abroad by Kalle & Co., of Biebrich-on-Rhine,
in the German Empire) and in what manner the same is to be performed to
be particularly described and ascertained in and by the following statement; —
This invention relates to the preparation of odourless and taseless compounds
of iodol (tetraiodopyrrol) with albumen for use as medicine for internal appli-
cation, the said compounds containing the iodol" in a chemically bound, or
absorbed, condition, as the components of the said compounds cannot be sepa-
rated mechanically. The dissolved albuminous body may be brought, in the
presence of the iodol, to a state of coagulation. I illustrate the nature of the
invention and the manner of carrying the same into effect by the following
examples to which however the invention is not limited.
EXAMPLE I.
100 grammes of pure white of egg are dissolved in 500 cubic centimetres of
water, and, to this solution, a solution of 20 grammes of iodol, in 200 cubic
centimetres of soda lye, is added, superadding, immediately, the quantity of
hydrochloric acid required for neutralization.
Coagulation will begin at once and become complete after active stirring for
a short time. The compound of iodol and albumen separates in flakes, is filtered,
thoroughly washed with water, and a little alcohol, and pressed and dried at
a moderate temperature. The powder obtained by disintegration, after drying,
is light yellow, and free from odour and taste; it is insoluble in water and
the other usual solvents and will only dissolve into a clear fluid upon being
heated continuously with diluted alkalies.
Instead of using the albumen of eggs, other albumens can be used such as
the albumen of blood, or milk, for example.
EXAMPLE II.
100 grammes of albumen are dissolved in 500 cubic centimetres of water
and mixed with 200 cubic centimetres of a five to six per cent. soda lye. The
mass immediately solidifies into a jelly which, when heated, will liquefy again.
As soon as liquefaction has set in there is added a solution of 20 grammes of
iodol in 100 cubic centimetres of five to six per cent. soda lye and 100 cubic
centimetres of water, and the mixture is neutralized with hydrochloric acid.
The product separates in coarse flakes. In other respects the method of pro-
cedure is the same as in Example I.
The compound obtained in accordance with Example II differs from that
obtained in accordance with Example I only in that it will, when heated, dis-

page_text: solve in alkaline liquors more readily and quickly. Besides the albumens
soluble in water, other albumens which, though insoluble in water, will dis-
solve in acids, or alkalies, and may be separated from these solutions again
by neutralization, may be employed for the purposes of this invention.
The proportions given in the foregoing examples for the concentration of the
novel product may be widely varied.
Having now particularly described and ascertained the nature of the said
invention and in what manner the same is to be performed I declare that what
I claim is:-
1. The manufacture of a chemical compound of iodol (tetraiodopyrrol) with
albumen by mixing solutions of albuminous bodies with solutions of iodol and
by subsequent coagulation of the albuminous bodies, substantially as described.
2. As new articles of manufacture products such as can be obtained as here-
inbefore described.
Dated this th 1.
1000
JOHNSONS & WILLCOX,
47, Lincoln's Inn Fields, London, W.C., Agents.