An Improved Manufacture of an Antiseptic and Microbicide.
Year: 1894

page_text: Date of Application, 13th Mar., 1894
Complete Specification Left, 10th Dec., 1894-Accepted, 12th Jan., 1895
PROVISIONAL SPECIFICATION.
An Improved Manufacture of an Antiseptic and Microbicide.
We, Dr. ALFRED KRAUS and ANTOINE CHEVRIER, Apothecary, both of
21 Boulevard Poissonnière, Paris, in the Republic of France, do hereby declare
the nature of this invention to be as follows:-
This invention relates to the manufacture of an antiseptic and microbicide,
which we will call "traumatol." The improved product may be employed like
iodoform which it advantageously replaces, inasinuch as it is inodorous, non-
poisonous and does not irritate the mucous membranes.
Traumatol (iodocresine, solid iodide of cresylic acid, solid iodide of methyloxy-
benzine, solid iodide of oxytoluene), is produced industrially in the following
manner:
At a suitable temperature we cause solid metallic iodine or metallic iodine
dissolved in caustic lyes, in solutions containing iodides, in any liquids adapted for
dissolving iodine, or else solid or liquid mixtures containing iodine or iodides,
especially in the presence of iodic acid, to act upon oxytoluene (cresylol, cresylic
acid, cresol, cresyl, methyl oxybenzine) or upon oxytoluene (cresylol, cresylic acid,
cresol, cresyl, methyl oxybenzine) dissolved in caustic lyes or other alkaline liquids,
or upon other liquids containing oxytoluene (cresylol, cresylic acid, cresol, cresyl,
methyl oxybenzine) in a state of solution or emulsion, or else upon solid or liquid
cresylates or salts of cresylic acid.
By this action we obtain an extremely fine and inodorous pulverulent precipitate
of reddish purple colour which is our new product "traumatol " (iodide of
oxytoluene, iodocresylol, solid iodide of cresylol, solid iodide of cresylic acid)
which is washed and then dried.
The product "traumatol" thus obtained may be employed as such or presented in
any other desired forms such as heretofore used for iodoform.
Dated this 13th day of March 1894.
HASELTINE, LAKE & Co.,
45, Southampton Buildings, London, W.C., Agents for the Applicants.
An Improved Manufacture of an Antiseptic and Microbicide.
We, ALFRED KRAUS, Doctor of Sciences, Chemist of 10 Rue Marbeuf, Paris,
France, and ANTOINE CHEVRIER, Dispensing Chemist, of 21 Faubourg
Montmartre, Paris, France do hereby declare the nature of this invention and
in what manner the same is to be performed, to be particularly described and
ascertained in and by the following statement:-
This invention relates to a new antiseptic and microbicide product which we
will call "traumatol," and to a process for manufacturing the said new product.
The new product may be employed like iodoform which it advantageously
[Price 8d.1

page_text: replaces inasmuch as it is inodorous, non poisonous, and has the property of
counteracting fermentation; moreover, it does not irritate the mucous
membranes.
The said product, to which we have given the fancy name of "traumatol " but
which, scientifically speaking, can be termed either "iodocresyl," "iodocresine,"
"iodo-cresylol ""solid iodide of cresylic acid," "iodide of cresylol" or "solid iodide
of oxytoluene," is produced industrially in the following manner.
At a suitable temperature, say from 45 to 65 degrees Centigrade, and either at
the atmospheric pressure or a higher one, we cause either solid metallic iodine or
metallic iodine dissolved in caustic lyes or in solutions containing iodines, or in
any liquids adapted for dissolving iodine, or again solid or liquid mixtures
containing iodine or iodides, to act either upon oxytoluene (C'HBO) (cresylol, cresylic
acid, cresol, cresyl, methyl, oxybenzine,) or upon oxytoluene dissolved in caustic lyes
or other alkaline liquids or again upon other liquids containing oxytoluene in a state
of solution or emulsion, or again finally upon solid liquid cresylates or salts of
cresylic acid.
The proportions which I consider the best are: 5 molecules of iodine (or an
equivalent weight in the case of iodides) to 1 molecule of oxytoluene. When the
oxytoluene is in a state of solution or emulsion, it is dissolved or emulsioned in the
proportion of 1 molecule of oxytoluene to 1 molecule of hydrate of sodium or
potassium or an equivalent weight of an alkali.
By the hereinbefore described action, we obtain an extremely fine and inodorous
pulverulent precipitate of reddish purple colour; the said powder is washed and
dried by the ordinary means and constitutes our new product which we call
"traumatol."
The said product may be employed in the form in which it is obtained or in any
other form such as heretofore used for iodoform.
Instead of using cresol (C'HO) the cost of which is a very high one, we may
preferably employ crude cresol obtained from coal-tar and distilling at. a
temperature ranging between 180 and 210 degrees Centigrade. But in such case,
we subject such crude cresol to the action (preferably) of iodine in presence of
iodic acid, for the purpose of annihilating the action of the iodhydric acid which
might take place and decompose a portion of the iodides already formed.
The reaction which takes place may be explained as follows:
5 C'HO +212 + HIO³ = 5 C'H'IO + 3 H2O.
Having now particularly described and ascertained the nature of the said inven-
tion and in what manner the same is to be performed, we declare that what we
claim is:
1. The herein before described product termed
chemical combination of iodine and cresol and having the properties set forth,
traumatol," consisting of a
substantially as described.
2. The hereinbefore described process for the manufacture of the herein-
described product, set forth in Claim 1, consisting in subjecting cresol to the action
of metallic iodine or a solution of iodine, as described, thus forming an odourless
precipitate of reddish purple color which is subsequently washed and dried,
substantially as described.
3. The hereinbefore described process of treating crude cresol obtained by
distilling coal-tar at a temperature ranging from 180 to 210 degrees Centigrade,

page_text: and intended for use in the manufacture of the product set forth in Claim 1, the
said process consisting in treating the crude cresol by means of iodine, preferably
in presence of iodic acid, substantially as and for the purpose set forth.
Dated this 10th day of December 1894.
For the Applicant,
W. LLOYD WISE,
46, Lincoln's Inn Fields, London, W.C., Chartered Patent Agent.