Manufacture of a Compound of Antipyrine and Iodine.
Year: 1890

page_text: Date of Application, 1st Dec., 1890
Complete Specification Left, 6th Aug., 1891-Accepted, 12th Sept., 1891
PROVISIONAL SPECIFICATION.
[Communicated from abroad by THE FARBWERKE VORMALS MEISTER LUCIUS
AND BRUNING, of Hochst-am-Maine, in the German Empire.]
Manufacture of a Compound of Antipyrine and Iodine.
I, OLIVER IMRAY of No. 28 Southampton Buildings, Chancery Lane in the
County of London, Fellow of the Institute of Patent Agents, do hereby declare
the nature of this invention :-
This invention relates to the manufacture of a compound formed by the action of
iodine upon antipyrine.
The following example illustrates the way in which the invention may be
carried out.
2 parts by weight of antipyrine are dissolved in 20 parts by weight of water and
heated to boiling temperature.
To the solution are alternately added portions, first of potassium carbonate; and
then of iodine in fine powder, in all 3 parts by weight of potassium carbonate and
28 parts by weight of iodine. Care is to be taken that there shall never be more
than a small excess of potassium carbonate and that, while the heat is maintained,
no fresh portion of iodine shall be added until the preceding portion has completely
disappeared.
The crude product separates in the form of a yellowish-brownish powder, which
is washed with water and recrystallized from diluted alcohol.
In a pure state it presents itself in the form of brilliant white prismatic needles,
having a melting point of 158° to 160° C.
In water it is nearly insoluble but is readily soluble in hot alcohol.
For the potassium carbonate may be substituted soda or free alkali or an alkaline
earth.
Dated this 1st day of December 1890.
ABEL & IMRAY,
Agents for the Applicant.
COMPLETE SPECIFICATION.
Manufacture of a Compound of Antipyrine and Iodine.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Fellow of the Institute of Patent Agents, do hereby declare
the nature of this invention and in what manner the same is to be performed,
to be particularly described and ascertained in and by the following statement :-
This invention relates to the manufacture of a compound formed by the action of
iodine upon antipyrine.
The following example illustrates the way in which the invention may be carried
out:
2 parts by weight of antipyrine are dissolved in 20 parts by weight of water and
heated to boiling temperature. To the solution are alternately added portions, first
of potassium carbonate, and then of iodine in fine powder, in all 3 parts by weight
of potassium carbonate and 2.8 parts by weight of iodine.
Care is to be taken that there shall never be more than a small excess of potassium
carbonate and that while the heat is maintained no fresh portion of iodine shall be
added until the preceding portion has completely disappeared.
The crude product separates in the form of a yellowish brownish powder, which
is washed with water and recrystallised from diluted alcohol.

page_text: In a pure state it presents itself in the form of brilliant white prismatic needles,
having a melting point of 158° to 160° C.
In water it is nearly insoluble but it is readily soluble in hot alcohol.
For the potassium carbonate may be substituted soda, a free alkali or an alkaline
earth.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I
claim is:
:-
1. The herein described process for producing a compound of antipyrine and
iodine by the action of iodine upon antipyrine in the presence of alkali, carbonate
of alkali or alkaline earth.
2. As a new product the compound of antipyrine and iodine above referred to.
Dated this 6th day of August 1891.
ABEL & IMRAY,
Agents for the Applicant.