Production of Certain Organic Therapeutic Preparations.
Year: 1896

page_text: PROVISIONAL SPECIFICATION.
Production of Certain Organic Therapeutic Preparations.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention (as communicated to me from abroad by F. Hoffmann-La Roche & Co. of
Basle, Switzerland, Manufacturing Chemists) to be as follows:-
The result of long continued research in the field of organic therapeutics was the
recent separation by my foreign correspondents, of the albumens containing iodine
and of the active constituents of the scutiform gland by precipitating them by means
of tannic acid and its derivatives from a solution of thyreoidea obtained from
suctiform glands by means of a solution of common salt.
The continuation of these researches has shewn that it is possible by means of
the same process also to separate the albumens and active constituents from other
organs.
This research has at present extended to the following organs :-The atrabilarian
kidney gland, the hypophysis, the spleen, the ovaries, the prostate gland, tlie
testicles, the tonsils, and the thymus, the process being generally as follows:-
The fresh animal organs are freed from adhering flesh and fat particles, are
comminuted, and extracted twice with twice their weight of a 7 per cent, solution of
common salt for from 1 to 2 hours until they are entirely exhausted.
The two extracts are filtered and mixed with a solution of tannin about
10 per cent. strength or one of its derivatives, for example 30 grammes tannin to
1 kilo. of the fresh organ.
The whole is then heated in a steam bath until it is completely coagulated. It is
then filtered, and the contents of the filfer are washed with distilled water until an
evident tannin reaction is no longer produced. The mass is then dried at a gentle
heat and pulverized.
The preparations produced in this manner from the above mentioned organs are
all powders which readily dry of rose to light brown colour, without any admixture
of foreign substances and almost without smell or taste. The yield varies froin 3
to 10 per cent. according to the organ treated.
Dated this 22nd day of December 1896.
ABEL & IMRAY,
Agents for the Applicant.

page_text: Production of Certain Organic Therapeutic Preparations.
I, OLIVER IMRAY, of No. 28, Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention (as cominunicated to me from abroad by F. Hoffmann-La Roche & Co. of
Basle, Switzerland, Manufacturing Chemists) and in what manner the same is to be
performed, to be particularly described and ascertained in and by the following
statement :-
The result of long continued research in the field of organic therapeutics was the
recent separation by ny foreign correspondents, of the albumens containing iodine
and of the active constituents of the scutiform giand as described in the
Specification No. 16137 of 1896.
The continuation of these researches has shewn that it is possible by means of
the same process also to separate the albumens and active constituents from other
organs.
This research has at present extended to the following organs-The suprarenal
capsules, the hypophysis, the spleen, the ovaries, the prostate glands, the testicles,
the tonsils, and the thymus, the process being generally as follows:-
The fresh animal organs are freed from adhering flesh and fat particles, they are
comminuted, and extracted twice with twice their weight of a 7 per thousand solution
of common salt for from 1 to 2 hours until they are entirely exhausted.
The two extracts are filtered and mixed with a solution of tannin about 10 per cent.
strength or one of its derivatives, for example 30 gramines tannin to 1 kilo. of the
fresh organ.
The whole is then heated in a steam bath until it is completely
coagulated. It is then filtered, and the contents of the filter are washed with
distilled water until an evident tannin reaction is no longer produced. The mass is
then dried at a gentle heat and pulverized.
The preparations produced in this manner from the above mentioned organs are all
powders which readily dry of rose to light brown colour without any admixture of
foreign substances and almost without smell or taste. The yield varies from 3
to 10 per cent. according to the organ treated.
Having now particularly described and ascertained the nature of this
invention and in what manner the same is to be performed, I declare that what I
claim is :-
1. The herein described production of therapeutic preparations in the form of
powder from the suprarenal capsules, the hypophysis, the spleen, the ovaries, the
prostrate glands, the testicles, the tonsils and the thymnus, by treating their saline
extract with tannin or its equivalent, coagulating and pulverising.
2. The organic therapeutic preparations produced as above set forth.
1L 10th dove of Contambor 1807
ABEL & IMRAY,
Agents for the Applicant.