New or Improved Compounds of Cocoa or Chocolate with Medicinal Substances.
Year: 1889

page_text: Date of Application, 11th July, 1889
Complete Specification Left, 9th Jan., 1890-Accepted, 15th Feb., 1890
PROVISIONAL SPECIFICATION.
New or Improved Compounds of Cocoa or Chocolate with Medicinal
Substances.
I FRANK LESLIE PHILLIPS of Moseley Road Birmingham in the County of
Warwick Doctor of Medicine and Surgeon do hereby declare the nature of this
Invention to be as follows:-
My invention consists of the new or improved compounds of cocoa or chocolate
with medicinal substances hereinafter described by the use of which compounds the
adminstration of the medicinal substances contained in them is facilitated and the
efficiency of the said medicinal substances exalted.
The compounds of cocoa or chocolate with medicinal substances made according to
my invention are used in the same way as ordinary cocoa or chocolate that is they
are made into a beverage with hot or boiling water with the addition where desired
of cream or milk and sugar. The compounds of cocoa or chocolate with medicinal
substances made according to my invention do not sensibly differ in taste from
ordinary cocoa or chocolate except in rare cases and persons drinking the said
beverages are unconscious from their taste of their medicinal character. In case of
insoluble or slightly soluble medicines the hot liquid in which they are suspended
and their minute division are conditions which largely increase the potency of the
medicines.
I will describe my invention in connection with compounds of cocoa with medicinal
substances.
The compounds constituting my invention are as follows:-
For a compound having a stimulating effect on the liver I add euionymin to cocoa
in the proportion of one grain of euonymin to one dram of cocoa. Or in place of
euonymin leptandrin or iridin in like proportion may be used or podophyllin in
proportion of one eighth of a grain to one dram of cocoa may be employed.
For a purgative cocoa I add one quarter of a grain of podophyllin and three grains
of cathartic acid to one dram of cocoa. For a more active compound one grain of
jalap resin or one grain of extract of cascara saqrada may be added.
For a stomachic or antacid cocoa I add ten grains of carbonate of bismuth to one
dram of cocoa.
For a stimulant or tonic cocoa I add one grain of lupulin and ten grains of extract
of coca leaves in powder to one dram of cocoa.
For a sedative cocoa to relieve headache nerve pains and rheumatism I add five
grains of phenacetin to one dram of cocoa.
The addition of the medicine to the cocoa is most conveniently effected in the
process of manufacturing the cocoa and is preferably added in the later stages of the
said manufacture.
In making compounds of chocolate with medicinal substances according to my
invention I employ the drugs herein before enumerated and in the proportions herein-
before enumerated replacing the cocoa with a like amount of chocolate.
Where the medicine mixed with the cocoa or chocolate gives an unpleasant flavour
to the beverage made from it it may be flavoured with vanila or other flavouring
material and where thought desirable flavouring materials may be employed where
there is no unpleasant flavour of the medicine to be counteracted.
Although I have described the medicines I prefer to employ in carrying my
invention into effect and the proportions which I have found to answer well in
SP C23

page_text: practice yet I do not limit myself to the proportions hereinbefore given neither do I
restrict myself to the use solely of the medicines 1 have described as in special cases
other medicines may be used in addition to those enumerated.
1
W. T. WHITEMAN,
Agent for the Applicant.
COMPLETE SPECIFICATION.
New or Improved Compounds of Cocoa or Chocolate with
Medicinal Substances.
I FRANK LESLIE PHILLIPS of Moseley Road Birmingham in the County of
Warwick Doctor of Medicine and Surgeon do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly described
and ascertained in and by the following statement :-
My invention consists of the new or improved compounds of cocoa or chocolate
with medicinal substances hereinafter described, by the use of which compounds the
administration of the medicinal substances contained in them is facilitated and the
efficiency of the said medicinal substances exalted.
The compounds of cocoa or chocolate with medicinal substances made according
to my invention are used in the same way as ordinary cocoa or chocolate, that is
they are made into a beverage with hot or boiling water with the addition where
desired of cream or milk and sugar. The compounds of cocoa or chocolate with
medicinal substances made according to my invention do not sensibly differ in taste
from ordinary cocoa or chocolate except in rare cases and persons drinking the said
beverages are unconscious from their taste of their medicinal character. In case of
insoluble or slightly soluble medicines the hot liquid in which they are suspended
and their minute division are conditions which largely increase the potency of the
medicines.
I will describe my invention in connection with compounds of cocoa with medicinal
substances.
The compounds constituting my invention are as follow,-
For a compound having a stimulating effect on the liver I add euonymin to cocoa
in the proportion of one grain of euonymin to one dram of cocoa. Or in place of
euonymin leptandrin or iridin in like proportion may be used; or podopbyllin in
proportion of one eighth of a grain to one dram of cocoa may be employed.
For a purgative cocoa I add one quarter of a grain of podophyllin and three.
grains of cathartic acid to one dram of cocoa.
For a
more active compound
one grain of jalap resin or one grain of extract of cascara saqrada may be added.
For a stomachic or antacid cocoa I add ten grains of carbonate of bismuth to one
dram of cocoa.
For a stimulant or tonic cocoa, I add, one grain of lupulin and ten grains of extract
of coca leaves in powder to one dram of cocoa.
For a sedative cocoa to relieve headache, nerve pains and rheumatism I add five
grains of phenacetin to one dram of cocoa.
The addition of the medicine to the cocoa is most conveniently effected in the
process of manufacturing the cocoa and is preferably added in the later stages of the
said manufacture.
In making compounds of chocolate with medicinal substances according to my
invention, I employ the drugs hereinbefore enumerated and in the proportion herein-
before enumerated replacing the cocoa with a like amount of chocolate.
Where the medicine mixed with the cocoa or chocolate gives an unpleasant
flavour to the beverage made from it, it may be flavoured with vanilla or other
flavouring material and where thought desirable flavouring materials may be
employed where there is no unpleasant flavour of the medicine to be counteracted.

page_text: Although I have described the medicines I prefer to employ in carrying my
invention into effect and the proportions which 1 have found to answer well in
practice yet I do not limit myself to the proportions herein before given neither do I
restrict myself to the use solely of the medicines I have described as in special cases
other medicines may be used in addition to those enumerated.
Having described the nature of my said invention I will proceed to explain the .
manner in which the same is to be performed.
Where the euonymin is pulverulent it is uniformly mixed with the cocoa by means
of a mortar and pestle. Where the euonymin is in sinall brittle lumps it is before
mixing with the cocoa reduced by trituration to a fine powder. Where the euonymin
is in small coherent lumps not sufficiently hard and brittle to be easily or readily
reduced to a powder by trituration as is sometimes the case especially with respect
to the green variety of euonymin I prefer to proceed in the following manner.
I macerate or steep the euonymin in rectified spirit of wine in the proportion of
one part by weight of euonymin to four parts by weight of the said spirit of wine.
The mixture should be frequently shaken to promote the solvent action of the spirit
upon the drug. After about seven days the spirit has extracted the whole or greater
part of the active principle of the drug and the liquid is separated from the
undissolved residuum by filtration or by decantation after the insoluble matter has
subsided. The alcoholic solution of the active principle of the euonymin thus
obtained is concentrated either by spontaneous evaporation in the air or preferably
by the application of a gentle heat. In the latter case the evaporation being
effected in a distillatory apparatus the evaporated spirit is recovered by conden-
sation. I prefer to concentrate the spirituous solution first obtained to about one
fourth its original volume but I do not limit myself to this proportion nor to the
sole use of the concentrated solution, as the solution as originally obtained may be
employed. In using the spirituous solution of enonymin it is added drop by drop to
the cocoa the latter being constantly stirred during the addition of the liquid. I
prefer not to employ the spirituous solution of euonymin excepting where from the
physical character of the particular sample of the drug employed it cannot readily and
satisfactorily be reduced to a fine powder.
The difficulty of reducing the drug to fine powder which I have referred to with
respect to euonymin, also obtains more or less with respect to iridin and leptandrin.
The particles of these drugs especially in a damp atmosphere have a tendency to
cohere and form small lumps. These lumps cannot be broken up with the certainty
required to effect a uniform mixture of the drug with the cocoa by the mixing machines
and screens used by apothecaries for mixing powders.
As the uniform distribution of the drug through the cocoa is of the first importance
I prefer in the case of all the drugs I employ to commence the mixing process by
hand labour. I prefer to take a small portion of cocoa about equal in weight to the
weight of euonymin or other drug taken and by hand trituration with a mortar and
pestle to effect an intimate incorporation of the cocoa and the drug. By this means
the particles of the drug are thoroughly disintegrated and the impalpable powder to
which the drug has been reduced uniformly distributed through the cocoa.
After this treatment a dilution of the mixture by the addition of a further quantity
of cocoa may be effected by mortar and pestle, after which the final mixing of the
drug and cocoa in the prescribed proportions may be effected by a mixing machine.
In making the purgative cocoa berein before referred to, the podophyllin resin and
the jalap resin are reduced to fine powder and mixed with the cocoa.
The cathartic
acid is dissolved in water and the solution added drop by drop to the cocoa containing
the podophyllin and jalap the cocoa being constantly stirred during the addition of
the solution of cathartic acid. The mixture is afterwards dried either by spontaneous
evaporation or by the application of a gentle heat.
If a flavouring material has to be added to a preparation of cocoa which has to be
dried such as the preparations hereinbefore described in which spirituous or aqueous-
solutions of the drugs have been employed the said flavouring material is added after

page_text: the drying that is after the, evaporation of the spirit or the water from the cocoa
preparation.
I have not thought it necessary to describe the manufacture of compounds of cocoa
with all the medicinal substances which I employ as I believe the detailed description
1 have given of the manufacture of euonymised cocoa is sufficiently explanatory of
the method or methods of mixing the said medicinal compounds with cocoa. The
application of my invention to chocolate differs in no material respect from its
application to cocoa as herein described.
Having now particularly described and ascertained the nature of my Inven-
tion and the manner in which the same is to be performed I declare that 1 claim as
my invention of "New or improved compounds of cocoa or chocolate with medicinal
substances":—
1. The compound having a stimulating effect on the liver herein described, namely,
a compound of cocoa or chocolate with euonymin or leptandrin or iridin or podophyllin
substantially as described.
.
2. The purgative compounds herein before described, namely, a compound of cocoa
or chocolate with podophyllin and cathartic acid and a compound of cocoa or chocolate
with jalap resin and a compound of cocoa or chocolate with extract of cascara saqrada;
all substantially as described.
3. The stomachic or antacid compound hereinbefore described, namely, a compound
of cocoa or chocolate with carbonate of bismuth substantially as described.
4. The stimulant or tonic compound herein before described namely a compound of
cocoa or chocolate with lupulin and extract of coca leaves substantially as described.
5. The sedative compound herein before described namely a compound of cocoa or
chocolate with phenacetin substantially as described.
Dated this 7th day of January 1890.
FRANK LESLIE PHILLIPS.