Antiseptic Compounds.
Year: 1899

page_text: Date of Application, 1st Feb., 1899-Accepted, 27th Jan., 1900
Antiseptic Compounds.
I, BENJAMIN JOSEPH BARNARD MILLS, of 23, Southampton Buildings, in the
County of London, Patent Agent, do hereby declare the nature of this invention
(a communication to me from Stafford Chemical Company, doing business at 603,
605, 607, Washington Street, in the City, County and State of New York, United
States of America), and in what manner the same is to be performed, to be
particularly described and ascertained in and by the following statement:-
The invention has reference to antiseptic compounds, and has for its objects to
produce a powerful and easily applicable germicide, which, when brought into contact
with the tissues and mucus membranes of the different parts of the body, will be
destructive to the living micro-organisms without injury to the parts in which they
exist and without causing pain or inconvenience to the patient, and which, after
having fulfilled its mission of killing the bacteria, will remain in contact with the
tissues as long as possible unchanged in its chemical and physical constituents and
thus inhibit for the corresponding time the development of bacteria, said remedy
being at the same time neither toxic nor irritant, that is to say, it will not be
absorbed so as to cause any general or local ill effect upon the human system.
In carrying out the invention I proceed as follows:-
-
Eighty (80) lbs. of glucose are dissolved in four (4) gallons of water, and to the
solution is added forty-four and one-half (44) lbs. of borax, and the whole heated to
about 200 degrees F. and stirred until the borax is completely dissolved. To the
solution, while hot, are then gradually added forty (40) fluid ounces of hydrofluoric
acid about 56° B. and then ninety-six (96) ounces of benzoic acid, and the whole
stirred until solution is effected. The solution is then allowed to cool and the
volume brought to eighteen (18) gallons by the addition of water. To the diluted
solution is added formaldehyde in proportion of one-half (½) of one per cent. of the
whole volume of the solution. Previous to the addition of the formaldehyde, the
diluted solution is preferably clarified by settling,.it being usually permitted to stand
for about four weeks.
An analysis of the preparation obtained as above described gave the following

page_text: salts of the dextrose and dextrine borates, and also sodium fluoride and sodium
benzoate. The formaldehyde simply intermixes.
While I have herein mentioned the use of glucose in the preparation of the
antiseptic compound, it is, of course, to be understood that dextrose and dextrine
could be used instead of glucose, which latter consists substantially of eighteen (18)
parts by weight of water and forty-one (41) parts each of dextrose and dextrine.
Either dextrose or dextrine may be used alone, but better results are obtained by the
use of both, as in glucose; or another gum vehicle may be substituted for the same,
but glucose is preferably used as it forms a film, soluble in water, after application to
the epidermis. Instead of using borax, the salt (sodium) may be introduced into the
solution in equivalent proportions, combined with the hydroflouric acid, say as a
fluoride of sodium, or it may be combined with benzoic acid as a benzoate of
sodium.
I would here remark that although the compound prepared as above is preferred,
I wish it to be understood that useful compounds may be obtained by the use of some
and the omission of other of the ingredients above mentioned. For instance, useful
compounds may be made by combining dextrose or dextrine or both dextrose and
dextrine with borax and hydrofluoric acid; other useful compounds may also be made
by combining dextrose and dextrine and borax with either benzoic acid, formaldehyde
or bydrofluoric acid, or with any two of such ingredients.
In producing any of these latter combinations the various ingredients are treated
and combined in the manner described with respect to the first described compound.
Having now particularly described and ascertained the nature of the said inven-
tion, and in what manner the same is to be performed, I declare that what I
claim is:-
1. An antiseptic compound composed of dextrose, borax and hydrofluoric acid,
substantially as described.
2. An antiseptic compound composed of dextrine, borax and hydrofluoric acid,
substantially as described.
3. An antiseptic compound composed of dextrose, dextrine, borax and hydrofluoric
acid, substantially as described.
4. An antiseptic compound composed of dextrose, dextrine, borax and benzoic
acid, substantially as described.
5. An antiseptic compound composed of dextrose, dextrine, borax and formaldehyde,
substantially as described.
6. An antiseptic compound composed of dextrose, dextrine, borax, hydrofluoric
acid and benzoic acid, substantially as described.
7. An antiseptic compound composed of dextrose, dextrine, borax, hydro-
fluoric acid and formaldebyde, substantially as described.
8. An antiseptic compound composed of dextrose, dextrine, borax, hydrofluoric
acid, benzoic acid and formaldehyde, substantially as described.
9. An antiseptic compound composed of dextrose, dextrine, borax, benzoic acid
and formaldehyde, substantially as described.
10. An antiseptic compound composed of glucose, water, borax, hydrofluoric acid,
benzoic acid and formaldehyde, substantially in the proportions specified.
11. An antiseptic compound composed of a gum vehicle, such as dextrine or
dextrose, borax and hydrofluoric acid, substantially as described.
Dated this 1st day of February 1899.
HARRIS & MILLS,
23, Southampton Buildings, London, W.C., Agents.