Year: 1898

page_text: Date of Application, 10th Feb., 1898
Complete Specification Left, 4th Nov., 1898-Accepted, 17th Dec., 1898
I, HENRY EDWARD NEWTON, of the Office for Patents, 6, Bream's Buildings,
Chancery Lane, in the County of London, Patent Agent, do hereby declare the
nature of this invention to be as follows:-
My foreign correspondents have found that if solutions of inorganic acids, such
as sulphurous acid, sulphuric acid, hydrochloric acid, phosphoric acid, boric acid,
or the like, or salts thereof, are allowed to act on albumen, or albuminous matters,
at elevated temperatures, albumoses are obtained.
In order to illustrate the new process, the following examples are given. The
parts are by weight.
EXAMPLE I.
15 parts of sulphurous anhydride are introduced into a mixture prepared by
mixing 25 parts of casein with 500 parts of water in an autoclave provided with
a stirring apparatus. The re-action mixture is heated, say, for 6 hours at about
90° Centrigrade, while continuously stirring. After this time, the sulphurous
anhydride is removed by allowing a current of hot air to pass through the liquid,
which is then energetically boiled up, and completely neutralized by means of
slaked lime, or lime water. Subsequently the liquid is filtered and evaporated
to dryness. A light yellow powder is thus obtained, which is readily soluble in
water, and represents a mixture of several known kinds of albumoses (caseoses),
and contains only small quantities of salts. It can be further purified by any of
the known methods in use for such purposes.
EXAMPLE II.
A mixture prepared from 100 parts of minced meat fibre which has been freed
from fat and glue, and 500 parts of dilute sulphuric acid containing 4 per cent.
of H₂SO is heated with continuous stirring for about 18 hours at about 90
degrees Centrigrade in an auto-clave lined with lead, and provided with a stirring
apparatus. After this time, the mixture is heated to boiling, and carefully
neutralized by means of barium hydroxide (Ba[OH]). Subsequently, it is
filtered, and the resulting filtrate is evaporated to dryness. The yellowish
powder thus obtained consists, for the most part, of a mixture of albumoses, and
can be purified in any known manner. It is readily soluble in water.
EXAMPLE III

page_text: is carefully neutralized by means of lime, heated to boiling, and filtered. The
filtrate represents a pale-gold-yellow liquid, which, when evaporated to dryness,
yields a yellowish powder. This powder is readily soluble in water, and repre-
sents a mixture of several kinds of known albumoses, and contains but small
quantities of salts.
EXAMPLE IV.
100 parts of minced meat fibre are mixed with 2000 parts of water and 50 parts
of boric acid in an autoclave provided with a stirring apparatus. The resulting
mixture is heated to from 80 to 100 degrees Centrigrade while being energetically
stirred. Heating and stirring is continued for about ten hours. After this time,
the autoclave is opened, the mixture heated to boiling point, and neutralized by
means of slaked lime. Subsequently it is filtered, and the resulting filtrate is
evaporated to dryness, and treated as before described.
Instead of the free acids used in the above examples, acid salts of these acids
can be employed.
In order to illustrate this method of proceeding, the following example is
given:
:-
EXAMPLE V.
10 parts of minced meat fibre are mixed with 10 parts of a watery solution of
bisulphite of lime (containing 5 per cent of this salt) in an autoclave provided
with a stirring apparatus. The mixture is heated for about 4 hours at about 90°
Centrigrade, with stirring. After this time, the resulting mixture is diluted by
means of water, heated to boiling, and rendered slightly alkaline by means of
slaked lime. Subsequently it is filtered. Into the resulting solution, a current
of gaseous carbonic acid is introduced, in order to precipitate the lime still con-
tained therein. The liquid is then cooled, and again filtered. Finally it is
evaporated to dryness. Thus, a yellowish white powder is obtained, which is
readily soluble in water, and represents a mixture of several kinds of known
albumoses.
It may be remarked that my foreign correspondents do not limit themselves to
the particulars given in the foregoing specification. The inorganic acids em-
ployed in the examples can be replaced by other inorganic acids, such as hydro-
chloric acid or the like, or acid salts thereof; the temperature and the degree of
dilution or concentration may be varied within wide limits, without altering
thereby the result of the process. In place of the albumens employed in the
examples, all other kinds of animal or vegetable albumens or albuminous
matters; also the different kinds of derivatives of albuminous matters can be
used, such as acid albumens, syntonines, albuminates, or the so-called methylen-
albumens, which are obtained by the action of formic aldehyde on albumen or
albuminous matter. Such or the like modifications do not alter the nature of the
present invention.
Dated this 10th day of February 1898.
NEWTON & SON,
Agents for the Applicant.
I, HENRY EDWARD NEWTON, of the Office for Patents, 6, Bream's Buildings,
Chancery Lane, in the County of London, Patent Agent, do hereby declare the

page_text: nature of this invention and in what manner the same is to be performed, to be
particularly described and ascertained in and by the following statement: -
My foreign correspondents have found that if solutions of inorganic acids, such
as sulphurous acid, sulphuric acid, hydrochloric acid, phosphoric acid, boric acid,
or the like, or acid salts thereof, are allowed to act on albumen or albuminous
matters at elevated temperatures, albumoses which are practically free from
peptones can be obtained.
In order to illustrate the new process, the following examples are given. The
parts are by weight.
EXAMPLE I.
15 parts of sulphurous anhydride are introduced into a mixture prepared by
mixing 25 parts of casein with 500 parts of water in an autoclave provided with a
stirring apparatus. The reaction mixture is heated, say, for 6 hours, at about
90° Centrigrade, while continuously stirring. After this time, the sulphurous
anhydride is removed by allowing a current of hot air to pass through the liquid,
which is then energetically boiled up, and carefully neutralized by means of lime
or lime water. Subsequently, the liquid is filtered and evaporated to dryness.
A light yellow powder is thus obtained, which is readily soluble in water, and
represents a mixture of several known kinds of albumoses (caseoses), and contains
only small quantities of salts.
EXAMPLE II.
A mixture prepared from 100 parts of minced meat fibre which has been freed
from fat and glue, and 500 parts of a dilute sulphuric acid containing 4 per cent.
of H,SO, is heated, with continuous stirring, for about 18 hours, at about
90 degrees Centrigrade, in an autoclave lined with lead, and provided with a
stirring apparatus. After this time, the autoclave is opened, and the mixture
is heated to boiling, and carefully neutralized by means of barium carbonate.
Subsequently it is filtered, and the resulting filtrate is evaporated to dryness.
The yellowish powder thus obtained consists for the most part of a mixture of
albumoses which are practically free from peptones. It is readily soluble in
water.
EXAMPLE III.
A mixture prepared from 50 parts of casein, 1000 parts of water, and 20 parts
of phosphoric acid, is heated for about 10 hours, with stirring, in a vessel lined
with lead, at about 90 degrees Centrigrade. After this time, the mass is care-
fully neutralized by means of lime, heated to boiling, and filtered. The filtrate
represents a pale gold-yellow liquid, which, when evaporated to dryness, vields
a vellowish powder. This powder is readily soluble in water, and represents a
mixture of several kinds of known albumoses, and contains but small quantities
of salts.
EXAMPLE IV.
100 parts of minced meat fibre, free from fat and glue, are mixed with 2000
parts of water and 50 parts of boric acid, in an autoclave provided with a stirring
apparatus. The resulting mixture is heated to from 80 to 100 degrees Centi-
grade, while being energetically stirred. Heating and stirring is continued for
about ten hours. After this time the autoclave is opened, the mixture heated to
boiling point, and carefully neutralized by means of slaked lime. Subsequently,
it is filtered, and the resulting filtrate is evaporated to dryness. The residue thus
obtained is readily soluble in water, and consists, for the most part, of a mixture
of albumoses which contain but small quantities of salts.
Instead of the free acids used in the above examples, acid salts of these acids
can be employed.

page_text: In order to illustrate this method of proceeding, the following example is
given:
EXAMPLE V.
10 parts of minced meat fibre free from fat and glue, are mixed with 10 parts
of a watery solution of bisulphite of lime (containing 5 per cent. of this salt), in
an autoclave provided with a stirring apparatus. The mixture is heated for about
4 hours, at about 100° Centigrade, with stirring. After this time, the resulting
mixture is diluted by means of water, heated to boiling, and rendered slightly
alkaline by means of slaked lime. Subsequently it is filtered. Into the resulting
solution, a current of gaseous carbonic acid is introduced, in order to precipitate
the lime still contained therein. The liquid is then cooled and again filtered.
Finally, it is evaporated to dryness. Thus, a yellowish-white powder is obtained
which is readily soluble in water, and represents a mixture of several kinds of
known albumoses.
It may be remarked that my foreign correspondents do not limit themselves
to the particulars given in the foregoing specification. The inorganic acids
employed in the examples can be replaced by other inorganic acids, such as
hydrochloric acid or the like, or acid salts thereof; the degree of dilution or
concentration may be varied within wide limits, without altering thereby the
result of the process.
The temperature can likewise be varied within certain limits, but in general
it is preferable to employ the temperatures given in the examples, because, in
this case, the best results will be obtained. My foreign correspondents point out
that it is not profitable to raise the temperature of the reaction mixtures far above
110 degrees Centigrade, because otherwise a considerable quantity of peptones
would be formed. In place of the albumens employed in the examples, all other
kinds of animal or vegetable albumens, or albuminous matters, also the different
kinds of derivatives of albuminous matters, can be used, such as acid albumens,
syntonines, albuminates, or the so-called methylen-albumens which are obtained
by the action of formic aldehyde on albumen or albuminous matters.
different kinds of bodies may be briefly termed "albumen compounds."
Such, or the like modifications, do not alter the nature of the present invention.
Having now particularly described and ascertained the nature of the said
invention and in what manner the same is to be performed (as communicated me
from abroad), I declare that what I claim is: -
All these
The process for producing albumoses practically free from peptones, by heating
albumen compounds with solutions of inorganic acids, or acid salts thereof,
substantially as herein before described.
Dated this 4th day of November 1898.