Year: 1899

page_text: Date of Application, 31st Ool., 1899-Accepted, 5th May, 1900
I, GEORGE LUDWIG SCHARFER, of 105, N. 11th Street, Brooklyn, in the County of
Kings and State of New York, United States of America, Chemist, do hereby declare
the nature of this invention and in what manner the same is to be performed, to
be particularly described and ascertained in and by the following statement :-
This invention relates to a new antiseptic medicinal compound and it consists of
the compound in the dehnite and general characteristics hereinafter more particularly
pointed out and claimed.
The invention consists of a metallic salt of a phenol derivative.
Phenols, as 18 well known, are bodies of noxious character, small doses administered
internally being sufficient to cause death. They have further, an irritant action on
the skin and mucous surfaces. According to my invention, the phenols are freed
from their poisonous and irritant properties.
In carrying out the invention, the phenols either the phenol guaiacol or beta-
naphthol are converted into their sulphonic acids by the notion of concentrated
sulphuric acid. The sulphonic acids are then neutralized by metallio salts such as
those of bismuth, strontium, lithium, iron, or other salts, in which processes the
carbonates, oxides or hydrates may be used, or the compounds may be produced by
double decomposition.
In manufacturing these salts of the phenolic sulphonic acids, I conveniently proceed
as follows: the guaiacol and beta naphthol are first treated with an excess of
concentrated sulphuric acid until the mixture is easily soluble in cold water. The
diluted acids are then shaken with benzol, ether, or other solvents to remove the
uncombined phenol. The residual mixture may then be separated in various manners.
If desired, the whole mass may be treated with a suitable base, resulting in a mixture
of sulphonate and sulphate which may be separated by crystallization. Any metallie
hydrate, oxide or carbonate may be used, but if those of lead, calcium or barium be
used, the sulphuric acid 18 at once removed leaving the sulphonates in solution and
from these any other metallic sulphonate may be obtained by double decomposition.
If the proper amount of the foregoing bases are used, a more or less pure solution of
the solphonic acids may be filtered off from the insoluble sulphates, and this is
neutralized with the carbonate, oxide or hydrate of the proper base. These salts may
be purified by repeated crystallization to separate the compounds of the different
sulphonic acids after which the desired sulphonate can be produced by double
decomposition of their salts with a salt of the desired base or by directly neutralizing
the free sulphonic acid with the desired hydrate, carbonate eto. In this connection,
the carbonate, hydrate or oxide of iron, strontium, lithium and bismuth can be
used.
The bismuth salts are in the form of fine powders not soluble in water and alcohol.
They are soluble in hydrochloric acid, forming the corresponding free sulphonic acid
and bismuth chloride. They are broken up by carbonate of sodium forming an
insoluble carbonate and a soluble sulphonate, the former of bismuth and the latter
of sodium.

page_text: The formula of the bismuth salts, though somewhat indefinite, are substantially as
follows:
CH.OH SO, bis beta naphthol sulphonate of bismuth.
CH,OH OCH SO, bis guaiacol sulphonate of bismuth.
The iron, strontium and lithium salts are crystallizable, soluble in water and
alcohol and are produced either in distinct crystals, containing water of crystallization
or as crystalline anhydrous powders. The salts are soluble in hydrochloric acid
forming the corresponding free sulphonic acids, and metallic chlorides. They are
broken up by carbonate of sodium forming into soluble carbonates and soluble
sulphonates.
The formulæ of these compounds which I consider most suitable for medicinal
purposes, although being susceptible of variations, may be stated as follows:
2 (CH,OH 80) fe beta naphthol sulphonate of iron.
2 (CHOH SO) er beta naphthol sulphonate of strontium.
CHOH SO, li beta naphthol sulphonate of lithium.
2(CH,OH OCH₂SO,) fe guaiacol sulphonate of iron
2 (CH,OH OCH SO) sr guaiacol sulphonate of strontium.
(C,H,OH OCH,SO) li guaiacol sulphonate of lithium.
I desire it understood that the stated method of producing the sulphonic acida can
be changed and that any desired method can be employed.
Having thus particularly described and pointed out my invention and the nature
and method of producing the same, what I claim is :-
1. The antiseptic medicinal compounds herein above referred to.
2. The compound consisting of a metallic salt of guaiacol sulphonic acid.
3. The compound consisting of a metallic salt of beta naphthol sulphonic acid.
4. The compound consisting of the bismuth salt of the phenol derivatives above
referred to.
The compound consisting of the from salts of the phonel domsatives abere
referred to.
erred to.
Dated this 30th day of October 1899.
For the Applicant,
J. G. LORRAIN, M.I.EE, M.I. Mech. E.,
Norfolk House, Norfolk Street, London, W.C, Chartered Patent Agent.