NEW COMBINATION OF MIXTURES FOR DIGESTIVE PURPOSES
Year: 1875

page_text: LETTERS PATENT to Joseph Lawson Petingale, of 55, New Bond
Street, in the Parish of Saint George's, Hanover Square, in the
County of Middlesex, for the Invention of "NEW COMBINATION OF
MIXTURES FOR DIGESTIVE PURPOSES."
>>;
Sealed the 20th June 1876, and dated the 23rd December 1875.
PROVISIONAL SPECIFICATION. left by the said Joseph Lawson
Petingale, at the Office of the Commissioners of Patents, with
his Petition, on the 23rd December 1875.
I, JOSEPH LAWSON PETINGALE, of 55, New Bond Street, in the
Parish of Saint George's, Hanover Square, in the County of Middlesex,
do hereby declare the nature of the said Invention for "NEW COMBINATION
OF, MIXTURES: FOR, DIGESTIVE PURPOSES," to be, as follows:-
For this purpose I take of pepsine, pancreatine, and diastase, a.greater
or lesser proportion, according to the nature of the case. For instance,
if the digestion of starchy matter is less active than the digestive of
nitrogenous or fatty matters I use a larger proportion of diastase.
When the digestive! power is, desired, to be increased in. the stomach I

page_text: relatively increase the pepsine beyond the proportion of the other two
digestive principles, and when it is desirable to assist the digestion in
the bowels the pancreatine becomes the more important constituent in
the mixture, and must be increased in its proportion. But in all
instances I prefer to have an admixture of at least two of these
principles, having found by experience that each of these materially
increases the digestive power of the other. For the same reason I
prefer for general purposes to have a certain amount of each of the
digestive principles, and that these may exert a higher digestive power
upon food, I furnish, together with the digestive compound, a dilute
solution of hydrochloric and lactic acids, kept separate in a suitable
vessel, and not mixed with the digestive principles until the latter are to
be taken, or as I much prefer it to be taken after further dilution at
from ten minutes to half an hour after the digestive compound has
been swallowed.
For generally enfeebled digestion I find a very useful proportional
composition of the digestive compound to be as follows:-16 parts of
pepsine, 12 parts of pancreatine, and 1 part of diastase, and this may
be advantageously diluted with 80 parts of good sugar of milk.
The dilute hydrochloric or lactic acids furnished with the digestive
compound as above should be again lowered in strength until the
acidity present is equal to about one per cent. of concentrated hydro-
chloric acid. But I have found that when the acid solution contains
greater acidity than would be represented by four per cent. of hydro-
chloric acid the processes of digestion are arrested instead of stimulated,
and if a lesser proportion is taken than one per cent. of acid it will
require a larger amount of such more diluted acid to accomplish the
most desirable digestive action. The amount or quantity of the one per
cent. solution of acid in proportion to the digestive compound. used may
be broadly taken as about 50 parts by weight of dilute acid to one of
the digestive compound.
A rather larger proportion of acid may be taken when greater
assistance has to be rendered to the digestion of the stomach, and
somewhat less is advisable when the digestive powers of the saliva or
of the pancreatic juice have to be augmented by means of this digestive
compound.
In former combinations of the digestive principles with acids in the

page_text: process of manufacture, a method which it has been found advantageous
to amend, so that the acids may be taken separately from the digestive
compound described and furnished with the acids, both being kept
separate until they are taken each at its appropriate period by the same
name of lactopeptine, and to enable me the better to dispense the
lactopeptine and acids in a convenient and desirable form, I place the
acids in a tube sealed at one end, or in a small bottle, and corked or
stopped preferably with india-rubber, which tube or bottle may be
conveniently passed through the cork or stopper of the bottle or vessel
containing the dry portion of the lactopeptine.
SPECIFICATION in pursuance of the conditions of the Letters Patent,
filed by the said Joseph Lawson Petingale in the Great Seal Patent
Office on the 23rd June 1876.
TO ALL TO WHOM THESE PRESENTS SHALL COME, I, JOSEPH
LAWSON PETINGALE, of 55, New Bond Street, in the Parish of Saint
George's, Hanover Square, in the County of Middlesex, send greeting.
WHEREAS Her most Excellent Majesty Queen Victoria, by Her
Letters Patent, bearing date the Twenty-third day of December, in the
year of our Lord One thousand eight hundred and seventy-five, in the
thirty-ninth year of Her reign, did, for Herself, Her heirs and suc-
cessors, give and grant unto me, the said Joseph Lawson Petingale, Her
special licence, that I, the said Joseph Lawson Petingale, my executors,
administrators, and assigns, or such others as I, the said Joseph
Lawson Petingale, my executors, administrators, and assigns, should at
any time agree with, and no others, from time to time and at all times
thereafter during the term therein expressed, should and lawfully might
make, use, exercise, and vend, within the United Kingdom of Great
Britain and Ireland, the Channel Islands, and Isle of Man, an Inven-
tion for "NEW COMBINATION OF MIXTURES FOR DIGESTIVE PURPOSES," upon
the condition (amongst others) that I, the said Joseph Lawson
Petingale, my executors or administrators, by an instrument in writing
under my, or their, or one of their hands and seals, should parti-
cularly describe and ascertain the nature of the said Invention, and in
what manner the same was to be performed, and cause the same to

page_text: be filed in the Great Seal Patent Office within six calendar months
next and immediately after the date of the said Letters Patent.
NOW KNOW YE, that I, the said Joseph Lawson Petingale, do hereby
declare the nature of my said Invention, and in what manner the same
is to be performed, to be particularly described and ascertained in and
by the following statement:-
· For this purpose I take of pepsine, pancreatine, and diastase, a greater
or lesser proportion, according to the nature of the case. For instance,
if the digestion of starchy matters is less active than the digestion of
nitrogenous or fatty matters I use a larger proportion of diastase.
When the digestive power is desired to be increased in the stomach I
relatively increase the pepsine beyond the proportion of the other two
digestive principles, and when it is desirable to assist the digestion in
the bowels the pancreatine becomes the more important constituent in
the mixture, and must be increased in its proportion.
.
But in all
instances I prefer to have an admixture of at least two of these
principles, having found by experience that each of these materially
increases the digestive power of the other. For the same reason I prefer
for general purposes to have a certain amount of each of the digestive
principles, and that these may exhibit a higher digestive power upon
food I furnish, together with the digestivé compound, a dilutė solution.
of hydrochloric and lactic acids, kept separate in a suitable vessel, and
not mixed with the digestive principles until the latter are to be taken,
or as I much prefer it to be taken after further dilution at from ten
minutes to half an hour after the digestive compound has been
swallowed..
For generally unfeebled digestions I find a very useful proportional
composition of the digestive compound to be as follows:-16 parts of
pepsine, 12 parts of pancreatine, and one part of diastase, and this may
be advantageously diluted with 80 parts of good sugar of milk.
The dilute hydrochloric or lactic acids furnished with the digestive
compound as above should be again lowered in strength until the acidity
present is equal to about one per cent. of concentrated hydrochloric
acid. But I have found that when the acid solution contains greater
acidity than would be represented by four per cent. of hydrochloric
acid the processes of digestion are arrested instead of stimulated, and if
a lesser proportion is taken than one per cent. of acid it will require a

page_text: larger amount of such more diluted acid to accomplish the most
desirable digestive action. The amount or quantity of the one per cent.
solution of acid in proportion to the digestive compound used may be
broadly taken as about 50 parts by weight of dilute acid to one of the
digestive compound.
A rather larger proportion of acid may be taken when greater
assistance has to be rendered to the digestion of the stomach, and
somewhat less is advisable when the digestive powers of the saliva or
of the pancreatic juice have to be augmented by means of this digestive
compound.
In former combinations of the digestive principles with acids in the
process of manufacture, a method which it has been found advantageous
to amend, so that the acids may be taken separatively from the digestive
compound, the name lactopeptine was adopted.
I propose to designate the digestive compound described and furnished
with the acids, both being kept separate until they are taken each at its
appropriate period, by the same name of lactopeptine, and to enable me
the better to dispense the lactopeptine and acids in a convenient and
desirable form I place the acids in a tube sealed at one end or in a
small bottle, and corked or stopped preferably with india-rubber, which
tube or bottle may be conveniently passed through the cork or stopper
of the bottle or vessel containing the dry portion of the lactopeptine.
In witness whereof, I, the said Joseph Lawson Petingale, have
hereunto set my hand and seal, this Twenty-third day of June,
in the year of our Lord One thousand eight hundred and
seventy-six.
JOSEPH LAWSON PETINGALE. (L.S.)