An Improved Process for Making a Compound of Good Keeping Property of Salicin, Saligenin, Glucose, and Free Hydrochloric Acid.
Year: 1896

page_text: Date of Application, 6th June, 1896
Complete Specification Left, 3rd Sept., 1896-Accepted, 24th Apr., 1897
PROVISIONAL SPECIFICATION.
An Improved Process for Making a Compound of Good Keeping
Property of Salicin, Saligenin, Glucose, and Free Hydrochloric
Acid.
A communication by the Firm of LUDWIG SELL & Co., of the Pharmaceutical
Products Factory; Pasing-Munich, in the Empire of Germany, Manufacturing
Chemists.
1, WILLIAM PHILLIPS THOMPSON, F.C.S., M.I.M.E., of The Agency for
Foreign Patent Solicitors, 6, Lord Street Liverpool, and 6, Bank Street,
Manchester both in the County of Lancaster, 118 New Street, Birmingham in
the County of Warwick and 322 High Holborn in the County of Middlesex,
Civil Engineer, do hereby declare the nature of this invention to be as
follows:-
.
This process is characterised by a partial decomposition of salicin as an extract.
by means of hydrochloric acid, whereby a dry compound of good keeping property
consisting of the extracted substances, viz. salicin, saligenin and glucose, and free
hydrochloric acid is obtained, which even when kept retains its original even
composition.
A fluid extract from the nuts of the horsechestnut (Aesculus yppocastanum) is
first prepared in the following manner: The nuts are roasted and then pounded as
fine as possible and boiled with sufficient water to yield a pasty mass. This after
cooling is extracted several times with dilute spirits of wine; the extracts are
decanted, the spirit drawn off and the residue concentrated to a thick extract.
This extract is then dissolved in as much dilute spirit treated with 5% glycerine,
as corresponds as a whole to the 10th part of the powdered mass treated.
After
standing some days it is filtered. The extract obtained in this manner contains to
each 100 parts of dry substance 6 parts of dextrose, as well as considerable
quantities of tannin.
The extract is then treated with about 5% of hydrochloric acid and digested
for two hours at a temperature of 75-100° C. The evaporations are afterwards
replaced by distilled water.
The analysis of the substance thus obtained yields per 100 parts of dry material,
079 parts of free hydrochloric acid and 33 parts of dextrose. The tannin is
decomposed.
The extract treated with acid is then mixed whilst hot with equal parts of
salicin and the mixture warmed in a boiling water bath for about 20 minutes, until
a clear reaction to saligenin takes place (produced by the decomposition of
salicin).
There is then added to the still warm mixture twice as much salicin as was
taken in the first instance, the whole is kneaded thoroughly, spread on glass plates
and the latter are allowed to lie at a temperature of 195 C. After about 24 hours,
an air dry powder is obtained which to 1 part contains 00438 parts free
hydrochloric acid and -018 parts dextrose; salicin and saligenin (salicylic alcohol)
are also contained.
It is essential for this meth d of production that the proportious of mixture and

page_text: temperatures should be exactly observed as only thereby can a substance such as
hereinbefore described be obtained.
It is also essential that the salicin should only be partially decomposed to a
fixed proportion, that free hydrochloric acid should still be present in the finished
substance and that the reducible substances-calculated in free dextrose-should
be present in a given quantity.
The thorough mixing of the separate constituents is also essential, and the
formation of mould arising in ordinary mixtures caused by further decomposition
of the salicin should no longer take place.
The final product of the process herein before described is a dark grey yellow
almost completely de-hydrated powder of good keeping property in contrast to the
ordinary compound of the original substances which soon decomposes, and which
is of a clear yellow colour and is not soluble in water.
Dated this 5th day of June 1896.
WM. P. THOMPSON & Co.,
Agents.
An Improved Process for Making a Compound of Good Keeping
Property of Salicin, Saligenin, Glucose, and Free Hydrochloric
Acid.
A communication by the Firm of LUDWIG SELL & Co., of the Pharmaceutical
Products Factory Pasing-Munich, in the Empire of Germany, Manufacturing
Chemists.
I WILLIAM PHILLIPS THOMPSON, F.C.S., M.I.M.E., of The Agency for
Foreign Patent Solicitors, 6, Lord Street, Liverpool, and 6, Bank Street,
Manchester, both in the County of Lancaster, 118 New Street, Birmingham, in
the County of Warwick, and 322, High Holborn, in the County of Middlesex,
Civil Engineer, do hereby declare the nature of this invention and in what
manner the same is to be performed, to be particularly described and ascertained
in and by the following statement :-
This process is characterised by a partial decomposition of salicin as an extract
by means of hydrochloric acid, whereby a dry compound of good keeping property
consisting of the extracted substances, viz. salicin, saligenin and glucose, and free
hydrochloric acid is obtained, which even when kept retains its original even
composition.
A fluid extract from the nuts of the horsechestnut (desculus hyppocastanum) is
first prepared in the following manner :-
The nuts are roasted and then pounded as fine as possible and boiled with
sufficient water to yield a pasty mass. This after cooling is extracted several
times with dilute spirits of wine; the extracts are decanted, the spirit driven off
and the residue concentrated to a thick extract. This extract is then dissolved in
as much dilute spirit treated with 5% glycerine, as corresponds as a whole to the
10th part of the powdered mass treated. After standing some days it is filtered.
The extract obtained in this manner contains to each 100 parts of dry substance
6 parts of dextrose, as well as considerable quantities of tannin.
The extract is then treated with about 5% of hydrochloric acid and digested
for two hours at a temperature of 75-90° C. The evaporations are afterwards
replaced by distilled water.
The analysis of the substance thus obtained yields per 100 parts of dry material,

page_text: 079 parts of free hydrochloric acid and 33 parts of dextrose. The tannin is.
decomposed.
The extract treated with acid is then mixed whilst hot with equal parts of
salicin and the mixture warmed in a boiling water bath for about 20 minutes, until
a clear reaction to saligenin takes place (produced by the decomposition of
salicin).
There is then added to the still warm mixture twice as much salicin as was-
taken in the first instance, the whole is kneaded thoroughly, spread on glass plates
and the latter are allowed to lie at a temperature of 19° C. After about 24 hours,
an air dry powder is obtained which to 1 part contains 00438 parts free-
hydrochloric acid and 018 parts dextrose; salicin and saligenin (salicylic alcohol)
are also contained.
It is essential for this method of production that the proportions of mixture-
and temperatures should be exactly observed, as only thereby can a substance such
as hereinbefore described be obtained.
It is also essential that the salicin should only be partially decomposed to a..
fixed proportion, that free hydrochloric acid should still be present in the finished
substance and that the reducible substances-calculated in dextrose-should be.
present in a given quantity.
The thorough mixing of the separate constituents is also essential, and the
formation of mould arising in ordinary mixtures caused by further decomposition
of the salicin should no longer take place.
The final product of the process herein before described is a dark grey yellow
almost completely de-hydrated powder of good keeping property in contrast to the
ordinary compound of the original substances which soon decomposes, and which.
is of a clear yellow colour and is not soluble in water.
Having now particularly described and ascertained the nature of the said inven-
tion and in what manner the same is to be performed, as communicated to me
by my foreign correspondents, I declare that what I claim is :-
A process for making a composition, of good keeping property, of salicin,.
saligenin, glucose, and free hydrochloric acid, characterized by exposing salicin as
an extract at a suitable temperature to the action of hydrochloric acid until a
reaction to saligenin takes place, then adding further salicin and bringing the
mixture at an ordinary temperature into a permanent or good keeping form,
substantially as herein before described.
Dated this 2nd day of September 1896.
WM. P. THOMPSON & Co.,.
Agents.