IMPROVEMENTS IN THE MANUFACTURE OF THE ALCALOIDES OF QUININA
Year: 1884

page_text: PROVISIONAL SPECIFICATION.
I FRANK WIRTH of the firm of Wirth and Company, Patent Solicitors of
Frankfort on the Main in the Empire of Germany, do hereby declare the nature
of the said invention for "IMPROVEMENTS IN THE MANUFACTURE OF THE
ALCALOIDES OF QUININA" to be as follows:-
This Invention relates to the production of the alkaloids of Quinine which have
hitherto only been obtained from Peruvian Bark.
The present invention depends on the discovery that the elementary body of
Quinine is found in plants of the genus Artemisia and can be obtained by extraction
in the ordinary method as used for Quinine Alkaloids.
The method therefore consists in the extraction of the elementary body of
Quinine from plants of the genus Artemisia. In carrying out this method I may
proceed generally as in the extraction of Quinine Alkaloid from Peruvian bark,
but the following method is strongly recominended.
The fresh or dried plant (the best is Artemisia Abrotanum Linn) must be chopped
fine with flowers and seeds together and digested in diluted acid (Sulphuric, hydro-
chloric acid etc.) The extracts obtained by the diluted acid are neutralized and
precipitated with a base. From the filtered moist basic mixture the alkaloids are
obtained by heat with schist oil, coal oil or petroleum having a low boiling point
or by means of alcohol. In the latter case the alcohol must be distilled off and
the residue must be absorbed by diluted acid and the alkaloid precipitated by
means of carbonate of soda.
By the solutions of the alkaloid in carburetted hydrogen the bases are more
easily carried over in the diluted acid and precipitated by the carbonate of soda.
Date LL
100

page_text: I FRANK WIRTH of the firm of Wirth and Company, Patent Solicitors of
Frankfort on the Main in the Empire of Germany, do hereby declare the nature
of the said Invention for " IMPROVEMENTS IN THE MANUFACTURE OF THE
ALCALOIDES OF QUININA," and in what manner the same is to bo performed, to
be particularly described and ascertained in and by the following statement:-
This Invention relates to the production of the alkaloids of Quinine which have
hitherto only been obtained from Peruvian bark.
The present invention depends on the discovery that the alkaloids of Peruvian
bark are found in plants of the genus Artemisia and can be obtained by extraction
in the ordinary method as Quinine alkaloids.
The method therefore consists in the extraction of these alkaloids from plants of
the genus Artemisia. In carrying out this method I may procced generally as in
the extraction of Quinine alkaloid from Peruvian bark, but the following method
is strongly recommended.
The fresh or dried flowers and seeds together with the whole plants (the best is
Artemisia Abrotanum Linn) must be chopped fine and digested in diluted acid
(sulphuric, hydrochloric acid etc :) The extracts obtained by the diluted acid are
neutralized and precipitated with a base. From the filtered moist basic mixture
the alkaloids are obtained by heat with. schist oil, coal oil or petroleum having a
low boiling point or by means of alcohol. Tu the Tatier case the alcohol must.be.
distilled off, the residue must be treated with diluted acid and the alkaloid
precipitated by means of carbonate of soda or another base.
From the solution in the hydrocarbons the alkaloids can be transformed into
salts by means of acid, and separated afterwards by means of carbonate of soda or
another base.
"
Having now particularly described and ascertained the nature of the said
Invention, and in what manner the same is to be performed, I declare that what
I claim is
In the manufacture of the alkaloids of Quinine, which ever be the method
employed, the substitution for Peruvian bark of the flowers and seeds and plants of
the genus Artemisia substantially as described.