Improvements in the Manufacture of Medicated Tabellae, Tablets, Tabloids, and Pellets.
Year: 1890

page_text: Date of Application, 9th June, 1890
Complete Specification Left, 9th Mar., 1891-Accepted, 6th June, 1891
PROVISIONAL SPECIFICATION.
Improvements in the Manufacture of Medicated Tabellae, Tablets,
Tabloids, and Pellets.
I, FREDERICK JANSON HANBURY of Plough Court, Lombard Street in the
City of London, Pharmaceutical Chemist, do hereby declare the nature of this
invention to be as follows:-
In the preparation of solutions for hypodermic injection, the use of materials
compressed into little tabellae or pellets has obtained amongst medical men,-the
advantage being that a determinate amount of the drug required to be injected is
thereby readily secured.
Attendant on the use of such tabellae or pellets, has been the necessity to
subject them to a crushing pressure, to effect their rapid solution in water, or, in
place of crushing, heat has been employed to dissolve the compressed pellet in
water.
Now, to avoid the necessity for the use of a pestle & mortar, or of a spirit lamp,
and to facilitate the solution of such compressed tabellac, tablets, tabloids, pellets,
or by whatever name called, charged with a drug suitable for hypodermic
injections, I now propose to prepare the same in the following manner :-
I mix with a measured quantity of the drug or alkaloid, suitable for an injection,
materials which, on immersion in water, will dissolve with effervescence. These
materials carefully mixed in a dry state, I then submit to pressure for the purpose
of consolidating the same, and thereby bringing to a solid state a definite amount
of the material required for the preparation of the solution.
In carrying out my invention, I use, in proportions suitable for forming a neutral
salt, a vegetable acid, such as citric or tartaric, and the bicarbonate of an alkali,
such as soda or potash, or I use an acid salt, either organic, such as bitartrate of
soda, or inorganic, such as bisulphate of soda, in place of a free acid. The
medicaments which I employ will be of various kinds, to suit the varied require-
ments of the practitioner, as, for example: morphia, aconitia, digitalia,
strychnine etc.
-
On dropping my improved tabellae, tablets, tabloids, or pellets, into water,
effervescence will immediately take place, and the compressed mass will be rapidly
disintegrated, while the bubbles of the disengaged carbonic acid gas adhering to
the mass will buoy it up to the surface.
By this twofold action, viz., disintegration and suspension, the solution of the
tabloid is rapidly effected.
Dated this 9th day of June 1890.
COMPLETE SPECIFICATION.
Improvements in the Manufacture of Medicated Tabellae, Tablets,
Tabloids, and Pellets.
I FREDERICK JANSON HANBURY of Plough Court, Lombard Street, in the
City of London, Pharmaceutical Chemist, do hereby declare the nature of this
invention and in what manner the same is to be performed, to be particularly
described and ascertained in and by the following statement:-—
In the preparation of solutions for hypodermic injection, the use of materials
compressed into little tabellac or pellets has obtained among medical men,-the
advantage being that a determinate amount of the medicament required to be
injected is thereby readily secured.

page_text: Mix and otherwise treat, as in the first example, the compound, and compress
the granulated mass into 2000 tablets, so that each shall contain of a grain of
sulphate of atropine.
may remark that so far as my experiments have enabled me to judge, my
invention is not applicable to medicaments of very unstable constitution, such,
notably, as apo-morphia.
Having now particularly described and ascertained the nature of my said
invention and in what manner the same is to be performed, I declare that what
I claim is :-
In the manufacture of medicated tabellae, tablets, tabloids, and pellets, to be
used for hypodermic injections, the combination with the medicament, of an acid
or acid salt and an alkaline carbonate, for the purpose of generating carbonic acid
gas, as and for the purpose above set forth.
1 01
NEWTON & SON,
Agents for the Applicant.