Year: 1897

page_text: A communication from abroad by KNOLL & Co., of Ludwigshafen on the Rhine,
Germany.
I, WILLIAM LLOYD WISE, of 46, Lincoln's Inn Fields, in the County of London,
Consulting Engineer and Chartered Patent Agent, do hereby declare the nature
of this invention to be as follows:-
It has been found that when solutions of albuminous compounds, such as egg-
albumen, peptone, and casein, are mixed with an iodoform-solution in the presence
of an albumen-precipitating medium, e.g., alcohol, a precipitate is produced that
consists of the kind of albumen employed and iodoform.
If this precipitate as such were allowed to be dried by the air or only gently
warmed, and then once or twice washed with an iodoform-dissolving medium such
as ether, or benzol, then almost the entire quantity of the iodoform up to about
1 or 2% would be dissolved, and consequently separated from the albumen.
It has, however, on the other hand been found that if the heating of the dried
precipitate has been continued to a higher temperature, e.g., 120° C., then-after
a small quantity of iodoform that has become superfluous in the precipitate has
escaped the main quantity of the iodoform, about 15 % has combined with the
albumen and can now be separated therefrom only with great difficulty and in
small quantity.
It has, moreover, been found that the compounds of iodoform and albumen thus
obtainable, are almost inodorous, and have the very important advantage that
when placed upon wound-dressings they give off no smell offensive to patients
or other persons although they fully possess the conspicuous antiseptic properties
that experience has shown to appertain to iodoform.
One mode of carrying out this invention is as follows:-
To a solution of 10 kilogrammes of albumen in 90 litres of water there are
added, whilst stirring, 15 kilogrammes of alcohol. In this mixture are dissolved,
with vigorous stirring, 2 kilogrammes of iodoform and there is then added to the
mixture another mixture of 10 kilogrammes of alcohol and 10 kilogrammes of
ether. The precipitate thereby formed is filtered-off and dried, then heated for a
few hours to about 120° C., again washed with ether or another iodoform-dissolv-
ing medium, and again heated to 120° C.
The preparation thus obtained gives an orange-yellow powder, which is almost
inodorous and capable of being sterilized and contains about 15% of iodoform.
For the purpose of combining these compounds of iodoform and albumen with
dressing-material, e.g., dressing-gauze, the prepared product itself, with or without
the addition of a binding material, such as may be employed, or the compounds
may be actually produced on the fibre of the dressing-material e.g., gauze may be
impregnated in a known manner with iodoform, then drawn through a solution

page_text: of albumen and then heated and possibly subjected to a subsequent washing.in
the bath.
Dated this 4th day of August 1897.
W. LLOYD WISE,
46, Lincoln's Inn Fields, London, W.C., Chartered Patent Agent.
Improvements in the Manufacture of Antiseptic Substances.
A communication from abroad by KNOLL & Co., of Ludwigshafen on the Rhine,
Germany.
I, WILLIAM LLOYD WISE, of 46, Lincoln's Inn Fields, in the County of London,
Consulting Engineer and Chartered Patent Agent, do hereby declare the nature
of this invention, and in what manner the same is to be performed, to be particu-
larly described and ascertained in and by the following statement:—
It has been found that when solutions of albuminous compounds, such as egg-
albumen, peptone, and casein, are mixed with an iodoform-solution in the presence
of an albumen-precipitating medium, e.g., alcohol, a precipitate is produced that
consists of the kind of albumen employed and iodoform.
If this precipitate as such were allowed to be dried by the air or only gently
warmed, and then once or twice washed with an iodoform-dissolving medium such
as ether, or alcohol or benzol, then almost the entire quantity of the iodoform up
to about 1 or 2 % would be dissolved, and consequently separated from the
albumen.
It has, however, on the other hand been found that if the heating of the dried
precipitate has been continued to a higher temperature, e.g., 120° C., then-after
a small quantity of iodoform that has been superfluous in the precipitate has
escaped the main quantity of the iodoform has combined with the albumen and
can then be separated therefrom only with comparatively greater difficulty and in
small quantities by means of iodoform solvents.
It has, moreover, been found that the compounds of iodoform and albumen thus
obtained, are almost inodorous, and have the very important advantage that
when placed upon wound-dressings they give off no smell offensive to patients
or other persons although they fully possess the conspicuous antiseptic properties
that experience has shown to appertain to iodoform.
One mode of carrying out this invention is as follows:-
To a solution of 10 kilogrammes of albumen in 90 litres of water there are
added, whilst stirring, 15 kilogrammes of alcohol. To this mixture are added,
with vigorous stirring, 2 kilogrammes of iodoform which have previously been
dissolved in a mixture of 10 kilogrammes of alcohol and 10 kilogrammes of ether.
The precipitate thereby formed is filtered-off and dried, then heated for a few
hours to about 120° C., washed several times with ether, or alcohol or other
iodoform-dissolving medium, and again heated to about 100° C.
The preparation thus obtained consists of a yellow powder, which is almost
inodorous and capable of being sterilized by means of the usual sterilizing process,
and contains about 12 % of iodoform.
For the purpose of combining these compounds of iodoform and albumen with
dressing-material, e.g. dressing-gauze, the prepared product itself, with or without
the addition of a binding material, such as albumen, may be employed, or the
compounds may be actually produced on the fibre of the dressing-material, e.g.

page_text: gauze may be impregnated in a known manner with iodoform, then drawn through
an aqueous solution of albumen, and then heated and, if necessary, subjected to a
subsequent short washing in a suitable bath formed of iodoform solvents in order
to remove any iodoform not combined with the albumen.
Having now particularly described and ascertained the nature of the said inven-
tion, and in what manner the same is to be performed, I declare that what I
claim is:-
.
The manufacture of an almost inodorous compound of iodoform with an
albuminous substance, such as egg-albumen, peptone, and casein, by bringing a
solution of the albuminous substance into contact with a solution of iodoform,
and heating the resulting precipitate for a few hours to a comparatively high
temperature e.g. 120° C., the product thus obtained being, if necessary, afterwards
washed with a medium capable of dissolving iodoform, as set forth.
W. LLOYD WISE,
46, Lincoln's Inn Fields, London, W.C., Chartered Patent Agent.