Manufacture of Bismuthoxyiodide-pyrogallate.
Year: 1897

page_text: Date of Application, 8th June, 1897
Complete Specification Left, 4th Feb., 1898-Accepted, 2nd Apr., 1898
Manufacture of Bismuthoxyiodide-pyrogallate.
I, HAROLD IMRAY, of No. 28, Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention (as communicated to me from abroad by F. Hoffmann-La Roche & Co., of
Basle, Switzerland, Manufacturing Chemists), to be as follows:—
My correspondents have found that by prolonged digestion of molecular
quantities of bismuthoxyiodide and pyrogallol, as also by precipitating a solution
of iodine salts and pyrogallol with an acetate solution of bismuth nitrate, a new com-
pound, bismuth oxyiodide pyrogallate is produced.
This new preparation of bismuth, which on account of its highly antiseptic pro-
perties, is applicable with advantage for pharmaceutical purposes, consists of an
exceedingly fine amorphous powder of a yellowish red colour, which is insoluble
in water and the usual solvents, and is not in any way affected by light or air.
The manufacture may be carried out as follows:-
EXAMPLE I.
Bismuthoxyiodide separated in the usual way from 12'1 kilos of crystallised
bismuth nitrate, is, after careful washing, mixed with several times its volume of
water, and is heated together with 3'1 kilos of pyrogallol on a steam bath under con-
tinued stirring, until the whole has assumed a fine yellowish red colour.
The precipitate is then collected on a filter, washed and dried under slight
heating.
EXAMPLE II.
Into a solution of 8'3 kilos potassium iodide and 6'3 kilos pyrogallol in 150 kilos
water are introduced, under brisk stirring, a solution of 24 kilos bismuth nitrate,
12 kilos sodium acetate, and 48 kilos of 60 per cent. acetic acid, in 100 kilos water.
The formation of the bismuthoxyiodidepyrogallate is assisted by slight heating;
the precipitate is separated on a filter, and is then suitably washed and dried under
slight heating.
In this example the potassium iodide can be replaced by another iodine salt,
or by hydrogen iodide.
Bismuthoxyiodide-pyrogallate possesses the advantage over bismuthoxyiodide
gallate, that it permits of a finer subdivision and that it is not so rapidly decom-
posed by water.
Dated this 8th day of June 1897.
ABEL & IMRAT,
Agents for the Applicant.

page_text: Manufacture of Bismuthoxyiodide-pyrogallate.
I, HAROLD IMRAY, of Birkbeck Bank Chambers, Southampton Buildings, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention (as communicated to me from abroad by F. Hoffmann-La Roche & Co.,
of Basle, Switzerland, Manufacturing Chemists), and in what manner the same
is to be performed to be particularly described and ascertained in and by the
following statement:.
My foreign correspondents have found that by prolonged digestion of molecular
quantities of bismuthoxyiodide and pyrogallol, as also by precipitating a solution
of iodine salts and pyrogallol with an acetic solution of bismuth nitrate, a new com-
pound, bismuth oxyiodide pyrogallate is produced.
This new preparation of bismuth, which on account of its highly antiseptic pro-
perties, is applicable with advantage for pharmaceutical purposes, consists of an
exceedingly fine amorphous powder of a yellowish red colour, which is insoluble
in water and the usual solvents, and is not in any way affected by light or air.
The manufacture may be carried out as follows:-
EXAMPLE I.
Bismuthoxyiodide separated in the usual way from 12'1 kilos of crystallised
bismuth nitrate, is, after careful washing, mixed with several times its volume of
water, and is heated together with 3'1 kilos of pyrogallol on a steam bath under con-
tinued stirring, until the whole has assumed a fine yellowish red colour.
The precipitate is then collected on a filter, washed and dried under slight
heating.
EXAMPLE II.
Into a solution of 83 kilos potassium iodide and 6'3 kilos pyrogailol in 150 kilos
water are introduced, under brisk stirring, a solution of 24 kilos bismuth nitrate,
12 kilos sodium acetate, and 18 kilos of 60 per cent. acetic acid, in 100 kilos water.
The formation of the bismuthoxyiodide-pyrogallate is assisted by slight heating;
the precipitate is separated on a filter, and is then suitably washed and dried under
slight heating.
In this example the potassium iodide can be replaced by another iodine salt,
or by hydrogen iodide.
Bismuthoxyiodide-pyrogallate possesses the advantage over bismuthoxyiodide
gallate, that it permits of a finer subdivision and that it is not so rapidly decom-
posed by water.
Having now particularly described and ascertained the nature of this invention a
and in what manner the same is to be performed, I declare that what I claim is:-
-
1. Process for the manufacture of bismuthoxyiodide pyrogallate consisting in
digesting molecular quantities of bismuth oxyiodide with pyrogallol or precipitat-
ing a solution of pyrogallol and iodine salts or hydrogen iodide with equivalent
quantities of an acetic solution of bismuth nitrate, substantially as described.
2. As a new manufacture, bismuth-oxyiodide pyrogallate produced as herein
described.
Dated this 4th day of February 1898.
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