IMPROVEMENTS IN MAKING OR MANU- FACTURING SULPHATE OF QUININE
Year: 1833

page_text: TO ALL TO WHOM THESE PRESENTS SHALL COME, I, JOSEPH
PELLETIER, of Easty's Hotel, Southampton Street, Strand, in the County of
Middlesex, Chemist, send greeting.
WHEREAS His most Excellent Majesty King William the Fourth did,
by His Letters Patent under the Great Seal of Great Britain, bearing date
at Westminster, the Twenty-fifth day of July, One thousand eight hundred
and thirty-three, in the fourth year of His reign, give and grant unto me,
the said Joseph Pelletier, and JEAN ADRIAN DESPREZ, His special licence,
that I, the said Joseph Pelletier, together with the said Jean Adrian Desprez,
our exors, admors, and assigns, and such others as I, the said Joseph Pelletier
and the said Jean Adrian Desprez, our exors, adiñiors, and assigns, shall at
any time agree with, and no others, from time to time and at all times
during the term of years therein mentioned, should and lawfully might
make, use, exercise, and vend, within England, Wales, and the Town of
Berwick-upon-Tweed, our Invention of "IMPROVEMENTS IN MAKING OR MANU-
FACTURING SULPHATE OF QUININE;" in which said Letters Patent there is
contained a proviso that I, the said Joseph Pelletier and' the said Jean Adrian
Desprez, should cause a particular description of the nature of our said
Invention, and in what manner the same is to be performed, to be enrolled
in His Majesty's High Court of Chancery within six calendar months next
immediately following the date of the said in part recited Letters Patent,
as in and by the same, reference being thereunto had, will more fully and at
large appear.
NOW KNOW YE, that in compliance with the said proviso; I, the said
Joseph Pelletier, on behalf of myself and the said Jean Adrian Desprez, do
+

page_text: hereby declare that the nature of our said Invention, and the manner in which
the same is to be performed, is as follows:-
I will first premise that its principal object is the production of sulphate of
quinine by means of distilled or expressed oils, whether derivable from vege-
table, animal, or mineral substances or matter as a substitute for and without
the aid of alcohol. I will now proceed to detail the mode of producing it where
distilled oil is intended to be used. The bark having been treated by acids,
and having precipitated the quinine and the other dissoluble matters in the
acid by.means of lime in the usual method used in the making of quinine, the
calcareous precipitate is to be dried and reduced to a fine powder; it is then
treated several times, say seven or eight, with the oil intended to be used, and
from my experience I have found turpentine oil to answer the best, which is
done in appropriate vases or other fit vessels found best calculated to answer
the object. The oil is then to be separated by decantation or filtration.
Where expressed oil is used care must be taken that the lime be first extracted,
otherwise a soap of lime insoluble would be formed. The precipitate must
then be dissolved in an acid, and the rough quinine be precipitated by ammo-
niac, when in this state it must be treated with the oil several times, which
will dissolve the quinine and separate from it all matter foreign to the same.
After obtaining the quinine in dissolution by expressed or distilled oils, the oil
is to be treated by water accidulated with any acid capable of forming a
soluble salt with the quinine (I prefer hydrochloric acid); the accidulated water
separates the quinine from the oil, the separation being easily effected by
decantation. As the two liquids having different specific weights will not com-
bine, the quinine thus dissolved is to be precipitated by an alkali, and after
that is reduced to sulphate by uniting it to sulphuric acid, care being taken
to saturate and whiten by animal charcoal, it is then crystalized by the method
usually adopted.
There is another mode of separating the quinine when dissolved in dis-
tilled oils, this mode is by application of heat in any of the known ways
used in the separation of liquids; but the process I consider less advantageous;
and I therefore prefer treating the oil by acidulated water. I claim as our
Invention the production of sulphate of quinine by the use of expressed or
distilled oils without the aid or intervention of, and as a substitute for, alcohol.
And I also claim all the benefits to be derived or derivable therefrom.
In witness whereof, I have hereunto set my hand and seal, this Twenty-
eighth day of August, in the year of our Lord One thousand eight
hundred and thirty-three.
JOSEPH (L.S.) PELLETIER.

page_text: AND BE IT REMEMBERED, that on the Twenty-seventh day of August,
in the year of our Lord 1833, the aforesaid Joseph Pelletier, through the
interpretation of Paul Janson, the said interpreter being first sworn that he
had duly interpreted the contents of this Specification to the said Joseph
Pelletier, came before our said Lord the King in His Chancery, and acknow-
ledged the Specification aforesaid, and all and every thing therein contained
and specified, in form above written. And also the Specification aforesaid
was stamped according to the tenor of the Statute made for that purpose.
Inrolled the Sixteenth day of October, in the year of our Lord One