Manufacture of Compounds of Casein with Aikaloids.
Year: 1899

page_text: Date of Application, 5th Jan., 1899-Accepted, 11th Feb., 1899
Manufacture of Compounds of Casein with Aikaloids.
I, CHARLES DENTON ABEL, of Birkbeck Bank Chambers, Southampton
Buildings, in the County of London, Consulting Engineer and Chartered Patent
Agent, do hereby declare the nature of this invention (as communicated to me
from abroad by Chemische Fabrik Rhenania, of Aachen, in the Empire of
Germany) and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement:-
It is known that complex bases such as quinine take effect in the organism
comparatively slowly and are frequently liable to disagree with invalids; on
this account it would be a great advantage to be able to exhibit the alkaloids as
medicaments in the form of proteid compounds such as are the most important
constituents of food.
The alkaloids can be combined easily with the proteid of milk, casein, when
this is in a moist, active condition, the compound or compounds produced being
of constant composition.
Thus by merely triturating the base with freshly precipitated moist casein
a distinct undoubted reaction is induced.
In the case of morphine the product is soluble in water whereas the products
obtained from casein and quinine, cinchonine, caffeine and the like are insoluble
in water but are soluble in alcohol.
That these products are chemical compounds is shewn by the fact that pro-
longed extraction of the finely divided substance with ether, chloroform or lika
solvents, fails to extract the alkaloid.
Alkalies which precipitate the alkaloids from solutions of their salts, and
alkali salts act differently towards these products.
The insoluble alkaloid-casein compounds can be prepared easily in a soluble
form by adding an alkali or an alkali salt to the mixture from which the com-
pound is prepared. The quinine-casein dissolves completely in water when an
adequate proportion of common salt is used; by prolonged heating with caustic
alkalies the compound is decomposed and the alkaloid crystallises when the solution
is cooled.
The alkaloid-casein compounds are dissolved easily by the dilute acids of the
gastric juice.
EXAMPLE I.
100 neste hr weight of nessin (aslculated as air-dried) are well triturated with

page_text: little alcohol. The mixture is warmed with dilute alcohol until it has become
uniform and is then dried at a low temperature.
To obtain a soluble preparation a small proportion of alkali or alkali salt is
added to the mixture of quinine and casein.
EXAMPLE III.
100 parts by weight of freshly precipitated casein (calculated as air-dried) are
triturated with 20 parts by weight of caffeine dissolved in hot alcohol or water and
dried at a low temperature.
By addition of an alkali salt the compound can be rendered soluble; like all
caffeine salts it is much less stable than are the corresponding quinine com-
pounds.
Having now particularly described and ascertained the nature of this
invention and in what manner the same is to be performed, I declare that what
I claim is:
1. The herein described manufacture of compounds of casein with alkaloids by
causing the alkaloid in alcoholic or other solution to react with casein, an alkali
or an alkali salt being added if necessary.
2. Compounds of casein with alkaloids manufactured substantially as herein
set forth.
Dated this 5th day of January 1899.
ABEL & IMRAY,
Agents for the Applicant.