The Manufacture or Production of Bismuthoxyiodide-methyl-gallate.
Year: 1896

page_text: Date of Application, 10th July, 1896
Complete Specification Left, 30th Dec., 1896-Accepted, 6th Feb., 1897
Communicated from abroad by THE CHEMISCHE FABRIK, vormals SANDOZ, of
Basel, Switzerland, Chemical Manufacturers.]
The Manufacture or Production of Bismuthoxyiodide-methyl-gallate.
I, WILLIAM EDWIN HEYS of 70 Market Street, Manchester in the County of
Lancaster, Patent Agent, do hereby declare the nature of this invention to be as
follows:-
In the Specification of Letters Patent No. 22902 dated the 26th November
A.D. 1894, there is described a combination of gallic acid with bismuthoxyiodide,
which has been used successfully in the treatment of wounds on account of its
antiseptic properties. It is the normal bismuthoxyiodide salt of gallic acid, and
its chemical composition is expressed by the formula :-
OH
,CO,Bi
\I
OH
C.H₂
)
OH
OH
My foreign correspondents have found that by treating bismuthoxyiodide with
the nethylether of gallic acid, described in the Specification of Letters Patent
No. 5953 dated the 23rd April 1887, a compound can be obtained having similar
properties, but differing essentially in chemical composition from the above
described compound. This new compound is a phenolic salt of gallic acid with
5 bismuthoxyiodide, whilst the methylether group remaius intact. Its formula is :-

page_text: The following is the simplest method known at present for the production of the
new compound. 10 kilos. of bismuth nitrate and 5 kilos. of sodium acetate are
dissolved in a little water with the addition of 10 kilos. of acetic acid. A solution
of 4.5 kilos. of the methylether of gallic acid and 3-5 kilos. of potassium iodide in
about 100 litres of luke-warm water is added at once, and the mixture is treated at
a temperature of about 40° to 50° C., until the precipitate, which was at first
brownish-red bismuthoxyiodide, has turned to a dark grey. The precipitate is
then well washed and dried below 100° C.
The Manufacture or Production of Bismuthoxyiodide-methyl-gallate.
I, WILLIAM EDWIN HEYS of 70 Market Street Manchester in the County
of Lancaster, Patent Agent, do hereby declare the nature of this invention,
and in what manner the same is to be performed, to be particularly described
and ascertained in and by the following statement :-
In the Specification of Letters Patent No. 22902 dated the 26th November
A.D. 1894, there is described a combination of gallic acid with bismuthoxyiodide,
which has been used successfully in the treatment of wounds, on account of its
antiseptic properties. It is the normal bismuthoxyiodide salt of gallic acid, and its
chemical composition is expressed by the formula:-

page_text: decomposes it only slowly in the same way. This property is of great importance-
for the medicinal application of this compound, as when it is used in the treatment
of wounds, the methylether of gallic acid and bismuthoxyiodide are formed, the
latter of which has the healing properties whilst the former acts as a strong
antiseptic agent.
In carrying out their invention my foreign correspondents prefer to proceed as.
follows:-
100 kilos. of bismuth nitrate and 5.0 kilos. of sodium acetate are dissolved in a.
little water with the addition of 100 kilos. of acetic acid. A solution of 4-5 kilos.
of the methylether of gallic acid and 3.5 kilos. of potassium iodide in about
100 litres of luke-warm water is added at once, and the mixture is treated, at a
temperature of about 40° to 50° C., until the precipitate, which was at first
brownish red bismuthoxyiodide, has turned to a dark grey colour. The precipitate,
which is the new compound, is then well washed, and dried at a temperature.
below 100° C.
Having now particularly described and ascertained the nature of my said inven-
tion and in what manner the same is to be performed, as communicated to me.
by my foreign correspondents, I declare that what I claim is :-
1. The hereinbefore described process for the manufacture or production of
bismuthoxyiodide-methylgallate by the action of methylgallate on bismuthoxyiodide,
substantially as hereinbefore described.
2. As a new substance, bismuthoxyiodide-methyl gallate, produced substantially
as and by the process herein before described.
AD 190e
WILLIAM E. HEYS..