Albumen Preparations, Soluble in Water, Made from Glycero- phosphates and Albuminoids.
Year: 1898

page_text: Albumen Preparations, Soluble in Water, Made from Glycero-
phosphates and Albuminoids.
I, OLIVER IMRAY, of Birkbeck Bank Chambers, Southampton Buildings, in
the County of London, Chartered l'atent Agent, do hereby declare the nature
of this invention (as communicated to me from abroad by the Firm of Bauer
& Co., of 80, Lindenstrasse, Berlin, in the Empire of Germany,) to be as
follows:-
According to the works of Robin and other authors, glycero-phosphates
increase the utilisation of albumen in the process of digestion.
They favour
moreover the circulation of sulphur, and the nervous assimilation of nutritive
phosphates in the organism. In consequence of these properties it appears
desirable to manufacture preparations which in addition to the glycero-phosphates
contain at the same time albuminoids in an easily resorbable form.
My correspondents have found, that glycero-phosphates are capable of render-
ing soluble in considerable quantity albuminoids which are insoluble in water,
thus rendering them easily assimilable.
If solutions prepared in this way are evaporated in vacuo at a low temperature,
very efficacious and also durable nutritive preparations are obtained which are
permanently soluble in water.
The process of manufacturing the preparations in question can be carried out
in several ways. Very good practical results are obtained by the example herein-
after described for carrying out the process.
The albuminoids (albuminates, caseine of milk, or vegetable caseine may be
used for this purpose) are mixed with water containing alcohol or with other
indifferent liquids, and the quantity of sodium-glycero-phosphate necessary for
rendering them soluble is added in small quantities while stirring up the mixture.
The latter is then gently heated and the small quantities of water are removed.
This is advantageously done by washing with strong alcohol, whereupon the
latter is removed by drying. In place of alcohol other indifferent liquids
(ether &c.) may be used.
The same purpose may be attained, though less easily, by mixing the said
albuminoids in excess and gently heating with a dilute aqueous solution of
sodium glycero-phosphate, and, after having let the mixture stand for some
time, the undissolved albumen is removed and the aqueous solution of albumen-
sodium-glycero-phosphate is dried in vacuo at a temperature of 40° C. Or, in
lieu of evaporating, the albumen-sodium-glycero-phosphate may bel precipitated
from the aqueous solution by means of alcohol.
Dated this 19th day of January 1898.
ABEL & IMRAY,
Agents for the Applicant.

page_text: Albumen Preparations, Soluble in Water, Made from Glycero-
phosphates and Albuminoids.
I, OLIVER IMRAY, of Birkbeck Bank Chambers, Southampton Buildings, in
the County of London, Chartered Patent Agent, do hereby declare the nature
of this invention (as communicated to me from abroad by the Firm of Bauer
& Co., of 80, Lindenstrasse, Berlin, in the Empire of Germany,) and in what
manner the same is to be performed to be particularly described and ascertained
in and by the following statement;-
-
According to the works of Robin and other authors, glycero-phosphates
increase the utilisation of albumen in the process of digestion.
They favour moreover the circulation of sulphur, and the nervous assimilation
of nutritive phosphates in the organism.
In consequence of these properties it appears desirable to manufacture pre-
parations which in addition to the glycero-phosphates contain at the same time
albuminoids in an easily resorbable form.
My correspondents have found, that glycero-phosphates are capable of render-
ing soluble in considerable quantity albuminoids which are insoluble in water,
thus rendering them easily assimilable.
If solutions prepared in this way are evaporated in vacuo at a low temperature,
very efficacious and also durable nutritive preparations are obtained which are
permanently soluble in water.
The process of manufacturing such preparations can be effected in several
ways. The following examples give good results.
(1) The albuminoid (such as albuminates, milk casein, or vegetable casein) is
mixed with water containing alcohol or with other indifferent liquids, and the
quantity of sodium glycero-phosphate necessary for making it soluble is added
by degrees while the mixture is stirred. The whole is then gently heated and the
water removed, advantageously by washing with strong alcohol, after which the
product is dried to eliminate the alcohol. Instead of alcohol other indifferent
liquids (such as ether) may be used.
(2) The albuminoid may be used in the form of its alkali compound, in which
case free glycero-phosphoric acid may be employed: thus the alkali compound
of casein, containing 80 grams of caustic soda in 4.3 kilos., is suspended in alcohol
and a concentrated aqueous solution of 172 grams of free glycerophosphoric acid
(calculated as being of 100 per cent. strength) is stirred into the mixture which
is then warmed and filtered, the product being finally washed, pressed and dried
(3) The albuminoid, in excess, is gently heated with a dilute aqueous solution
of sodium glycero-phosphate; after the mixture has been set aside for some time
the undissolved albumen is removed and the aqueous solution of albumen-
sodium-glycero-phosphate is dried in a vacuum at a temperature of 40° C.; or,
instead of evaporating the solution, the albumen-sodium glycero-phosphate may
be precipitated therefrom by means of alcohol.
The process No. (3) is less advantageous than Nos. (1) and (2).
Having now particularly described and ascertained the nature of this inven
tion and in what manner the same is to be performed, I declare that what
I claim is:
1. The manufacture of albumen preparations soluble in water by mixing
albuminoids, such as albuminates, milk casein or vegetable casein, suspended in

page_text: dilute alcohol, or in similar indifferent liquids, with the quantity of a glycero-
phosphate necessary for dissolving them and then heating the mixture, eliminat-
ing the alcohol and drying the product, substantially as described.
2. The manufacture of albumen preparations soluble in water by mixing
albuminoids, such as albuminates, milk casein or vegetable casein, with aqueous
solutions of a glycero-phosphate, filtering the mixture and evaporating the filtrate
in a vacuum or precipitating it by means of alcohol, substantially as described.
3. The albumen preparations soluble in water prepared as above set forth.
Dated this 3rd day of October 1898.
ABEL & IMRAY,
Agents for the Applicant.