Compounds for the Treatment of Gout and Analogous Diseases.
Year: 1898

page_text: PROVISIONAL SPECIFICATION.
Compounds for the Treatment of Gout and Analogous Diseases.
I, GEORGE WILLIAM JOHNSON, of 47, Lincoln's Inn Fields, in the County of
London, Patent Agent, do hereby declare the nature of this invention (which
has been communicated to me from abroad by the Vereinigte Chininfabriken
Zimmer & Co, of Frankfort-on-Maine, in the German Empire) to be as
follows:-
My foreign correspondents have succeeded in preparing from quinic acid a very
effective remedy for gout and other diseases due to uric acid. They have found
that quinic acid itself is a powerful anti-anthritic, but that its action is increased
by applying it in combination with lithia
Neutral lithium quinate may be used, but it has a disagreeable taste, and 18
not very stable It is better to employ acid lithium quinate, or a mixture of
lithium quinate, with excess of quinic acid, whereby the disagreeable flavour
18 completely suppressed, and converted into a pleasant, feebly acid, taste
Quinic acid can be also partly neutralised by another base, such as magnesia,
which has no noxious action on uric acid separation, and the magnesium
quinate thus obtained 18 mixed with a suitable lithium salt.
Free quinic acid, mixed with a lithium salt, can of course be used, but the
taste of this mixture is strongly acid, and it 18, therefore, more desirable to partly
fix the acid
The mixture of quinic acid and lithium salt 18 best applied in the form of
pastilles or effervescent powder or effervescent water. The following 18 an
example of a very efficient preparation, according to this invention, in the form
■01■ 18:51011108. Un the
U
088044168. UT THE HKUS
100 parts
5
"
83
66
دو
"
quinic acid
magnesia usta
lithium citricum
sugar
but many variations can be made; for example, instead of magnesia, other bases
can be used, and instead of lithium citrate, other lithium compounds can be
used. Quinic acid, unsaturated with a base, may also be used, in mixture with
a lithium salt.

page_text: COMPLETE SPECIFICATION
Compounds for the Treatment of Gout and Analogous Diseases.
I, GEORGE WILLIAM JOHNSON, of 47, Lincoln's Inn Fields, in the County of
London, Patent Agent, do hereby declare the nature of this invention (which
has been communicated to me from abroad by the Vereinigte Chininfabriken
Zimmer & Co, of Frankfort-on-Maine, in the German Empire) and in what
manner the same 18 to be performed to be particularly described and ascertained
in and by the following statement:―
My foreign correspondents have succeeded in preparing from quinic acid a very
effective remedy for gout and other diseases due to uric acid They have found
that quinic acid itself is a powerful anti-anthritic, but that its action is increased
by applying it in combination with lithia
Neutral lithium quinate may be used, but it has a disagreeable taste, and is
not very stable. It is better to employ acid lithium quinate, or a mixture of
lithium quinate with excess of quinic acid, whereby the disagreeable flavour
18 completely suppressed, and converted into a pleasant, feebly acid, flavour
Quinic acid can be also partly neutralised by another base, such as magnesia,
which has no noxious action on uric acid separation, and the magnesium
quinate thus obtained is mixed with a suitable lithium salt
Free quinic acid, mixed with a lithium salt, can of course be used, but this
mixture is strongly acid to the taste, and it 18, therefore, desirable to partly fix
the acid
The mixture of quinic acid and lithium salt is best applied in the form of
pastilles, or effervescent powder, or effervescent water. The following is an
example of a very efficient preparation, according to this invention, in the form
of pastilles, or the like. The parts are by weight
100 parts
quinic acid
As further examples 1 give for the preparation of pastilles or effervescent
powder
100.parts
16
"
84
"
quinio acid
carbonate of lithium
Bugar
and for the preparation of an effervescent water.
300 parts
48
36000
quinic acid
"
carbonate of lithium
carbonic acid water
Having now particularly described and ascertained the nature of this
invention and in what manner the same is to be performed, I declare that what
I claim 18-
1 As a remedy for gout and analogous diseases a combination of, or containing,
quinic acid and lithia, as hereinbefore described.

page_text: 2. As a remedy for gout and analogous diseases a combination of quinic acid
and lithia, with the quinic acid in excess, as hereinbefore described
3. As a remedy for gout and analogous diseases a combination of quinic acid,
lithia and magnesia, or equivalent base, as hereinbefore described
4. As a remedy for gout and analogous diseases a compound or effervescent
water made in accordance with either of the examples hereinbefore given.
Dated this 10th day of Anomma 1900
JOHNSONS & WILLCOX,
47, Lincoln's Inn Fields, London, W.C., Agents