Year: 1886

page_text: Date of Application, 11th Aug., 1886.
Complete Left, 23rd Apr., 1887.
Complete Accepted, 24th May, 1887
1, ALBERT KNOLL, Doctor of Philosophy, of Ludwigshafen on the Rhine, Germany,
do hereby declare the nature of this invention to be as follows:-
My process for obtaining the ethers of morphincarbonic acid is based on the
re-action of the ethers of chlorocarbonic acid on morphin, on morphin-alkalies, or on
the morphin-compounds of the earthy alkalies.
To produce, for instance, the methyl-ether of morphincarbonic acid, I dissolve one
part of morphin in five parts of absoluto alcohol, while adding the quantity of
alcoholic potash or soda necessary for the formation of morphin-alkali, after which I
add a slight excess of methyl-chlorocarbonate. The chemical transformation takes
place at once, and is attended with considerable development of heat. Subsequently I
neutralize by means of an acid, preferably sulphuric acid, relieve the product of
alcohol, extract the salt with water, add an excess of alkali and dissolve the methyl-
morphin-carbonate thus formed, by adding benzol and stirring. After the evaporation
of the solution there remains the methyl-inorphin-carbonate in the shape of a
crystalline mass. The ether combines with acid and forms salts having characteristic
qualities.
To obtain a maximum yield of ether, it is necessary, of course, to exclude water as
much as possible during the transformation, and subsequently to avoid a large excess
of alkalies or strong acids, especially at high temperatures, as the same would act on
the ether just produced, thus causing again the formation of free morphin.
In an analogous manner I produce the other ethers of morphin-carbonic acid.
Dated this 11th day of August 1886
FAIRFAX & WETTER,
433, Strand, London, W.C.,
Agents for the Applicant.

page_text: COMPLETE SPECIFICATION.
Process for the Production of the Ethers of Morphincarbonic Acid.
I, ALBERT KNOLL, Doctor of Philosophy, of Ludwigshafen on the Rhine, Germany,
do hereby declare the nature of my invention for PROCESS FOR THE PRODUCTION OF
THE ETHERS OF MORPHINCARBONIC ACID and in what manner the same is to be
performed, to be particularly described and ascertained in and by the following
statement:-
My process for obtaining the ethers of morphincarbonic acid is based on the re-action
of the ethers of chlorocarbonic acid on morphin, on morphin-alkalies, or on the
morphin-compounds of the earthy alkalies.
To produce, for instance, the methyl-ether of morphincarbonic acid, I dissolve one
part of morphine in five parts of absolute alcohol, while adding the quantity of
alcoholic potash or soda necessary for the formation of morphin-alkali, after which I
add a slight excess of methyl-chlorocarbonate. The chemical transformation takes
place at once, and is attended with considerable development of heat. Subsequently
neutralize by means of an acid, preferably sulphuric acid, relieve the product of
alcohol, extract the salt with water, add an excess of alkali and dissolve the methyl-
ether of morphincarbonic acid thus formed, by adding benzol and stirring. After the
evaporation of the solution there remains the methyl-ether of morphincarbonic acid in
the shape of a crystalline mass. The ether combines with acid and forms salts having
characteristic qualities.
To obtain a maximum yield of ether, it is necessary, of course, to exclude water as
much as possible during the transformation, and subsequently to avoid a large excess
of alkalies or strong acids, especially at high temperatures, as the same would act on
the ether just produced, thus causing again the formation of free morphin.
In an analogous manner I produce the other ethers of morphin-carbonic acid.
Having now particularly described and ascertained the nature of my said invention
and in what manner the same is to be performed, I declare that what I claim is :-
1. The process for the production of an ether of morphin-carbonic acid, which
consists in causing an ether of chlorocarbonic acid to act on morphin, or on a morphin-
alkali or on the morphin-compound of an earthy alkali.
2. Obtaining an ether of morphin-carbonic acid in the manner substantially as
described.
Datal thi, 09.1 1...
A 1005
FAIRFAX & WETTER,
433, Strand, London,
Agents for the Applicant.