Improvements in the Treatment of the Disulphones for Medicinal Purposes.
Year: 1889

page_text: Date of Application, 19th Nov., 1889
Complete Specification Left, 13th Aug., 1890-Accepted, 4th Oct.. 1890
PROVISIONAL SPECIFICATION.
Improvements in the Treatment of the Disulphones for Medicinal
Purposes.
I, GEORGE LUNAN Pharmaceutical Chemist, 35 George Street Edinburgh, do hereby
declare the nature of this invention to be as follows:-
A process to render the action of the disulphones, such as sulfonal, tetronal,
trional &c., active. The process which is applicable to any of the members of this
group consists in dissolving them in chloroform, ethylic alcohol, petroleum ether or
any other of their powerful solvents, distilling off the said solvents at a low
temperature, whereby the substances are left in an amorphous condition.
The powders thus prepared are afterwards acted on by hydrocarbon oils, including
the whole range of petroleum oils and other oleaginous solvents such as olive oil,
almond oil castor oil &c.
Dated this 18th day of November 1889.
GEORGE LUNAN,
35, George Street, Edinburgh.
COMPLETE SPECIFICATION.
Improvements in the Treatment of the Disulphones for Medicinal
Purposes.
I. GEORGE LUNAN, Pharmaceutical Chemist 35 George Street Edinburgh do
hereby declare the nature of this invention and in what manner the same is to be
performed, to be particularly described and ascertained in and by the following
statement:-
This invention relates to the improvement in the treatment of all the disulphones
including sulphonal or sulfonal, trional, tetronal, &c. so as to render them more
soluble and certain in their physiological action; and for which provisional protection
was granted me 19th November 1889, No. 18434.
It consists in adopting a process or processes for rendering these materials
amorphous, attained by processes hereafter described; and the action on the drugs
thus prepared of semisolvents or partial solvents useful to render them assimilable and
as a vehicle for exhibition for medicinal purposes.
In order that my invention may be more readily understood, I give details of the
general operation for these improvements.
The process consists in dissolving the sulfonal or any of the disulphones in any of
their more powerful solvents such as chloroform, ether, ethylic alcohol, petroleum
ether &c. removing the drug in a prepared condition by precipitation with water, or
the solvent by distillation or evaporation so as to leave the disulphone operated on in
an amorphous condition; acting on either or any of the drugs thus prepared with
any oleaginous solvent hereafter named, or while still in solution allowing the
operation of olive oil, castor oil, hydrocarbon or petroleum oils or jellies or any
oleaginous solvent whatever in conjunction with which the disulphones are then
conveniently exhibited with an improved activity for medicinal purposes.
This may be done either enclosed in a flexible gelatine capsule or in any membrane
of any material suitable for the purpose, or in any other way suitable for the prepared
drugs.

page_text: Having now particularly described and ascertained the nature of my said inven-
tion and in what manner the same is to be performed, I declare that what I
claim is
"The suspension and solution of sulfonal or sulphonal or any of the disulphones
in any oleaginous medium suitable for use in medicine as described."
Dated this 12th day of August 1890.
GEORGE LUNAN,
35, George Street, Edinburgh.