A New Pharmaceutical Compound.
Year: 1898

page_text: Date of Application, 25th May, 1898
Complete Specification Left, 23rd Feb., 1899-Accepted, 1st Apr., 1899
[Communicated from abroad by
& Co., of Elberfeld, Germany.]
A New Pharmaceutical Compound.
I, HENRY EDWARD NEWTON, of the Office for Patents, 6, Bream's Buildings,
Chancery Lane, in the County of London, Patent Agent, do hereby declare the
nature of this invention to be as follows:-
It is known that the reaction product which is obtained by the action of
⚫ tannin
tannin, or the like, on albumen compounds, and which is termed
albuminate," cannot be used for therapeutical purposes, because it is decom-
posed too easily by the action of dilute acids.
My foreign correspondents have now found that by treating the said product
with formic aldehyde, it is transformed into a new compound which represents
a very valuable remedy for intestinal diseases.
In order to illustrate the new process, the following example is given :-
EXAMPLE.
-
A solution of 175 kilos. by weight, of egg-albumen in 8 litres of water, is
mixed at ordinary temperature with a solution of 25 kilos. by weight of tannin
in 5 litres of water, the well-known "Tannin albuminate" being precipitated.
Subsequently 05 litres of a watery solution of formic aldehyde (containing
about 40 per cent. of CHO) is added to the reaction mixture, and the whole
mixture is then heated on a water bath for about 10 hours while continuously
stirring. During this operation, the "tannin albuminate," being in the shape
of a viscous precipitate, is by-and-by transformed into a granular mass which
represents the new product. The reaction will be finished when a test portion
of the precipitate, filtered off, is found to be no longer immediately soluble in a
cold dilute caustic lye.
1
At this stage, the whole precipitate is filtered, washed with warm water, in
order to remove the free formic aldehyde still contained therein, and dried at
about from 50 to 60 degrees Centigrade.
When dry and pulverized, the new compound is a light yellow powder, in-
soluble in water and in alcohol, ether, & benzine.
In dilute caustic lyes, it does not dissolve immediately, but if it is treated
for a long while with dilute caustic lyes, it is eventually dissolved, undergoing
decomposition. The new product is not decomposed by dilute acids, and there-
fore it can be profitably used as an intestinal astringent which has no detri-
mental action on the stomach.
On using other albumen compounds, such as serum-albumen, vegetable
albumen, or the like, instead of egg albumen, the process proceeds in the same
manner

page_text: It may be remarked that my foreign correspondents do not intend to confine
themselves to the particulars given in this specification, as the example is
merely typical, and can be varied within wide limits.
1
954. * 1000
NEWTON & SON,
Agents for the Applicant.
A NEW Farmaceutical compound.
I, HENRY EDWARD NEWTON, of the Office for Patents, 6, Bream's Buildings,
Chancery Lane, in the County of London, Patent Agent, do hereby declare the
nature of this invention and in what manner the same is to be performed, to be
particularly described and ascertained in and by the following statement:-
It is known that the reaction product which is obtained by the action of
tannin, or the like, on albumen compounds, and which, in' the following specifi-
cation, will be termed "tannin albuminate," cannot be used for therapeutical
purposes, because it is decomposed too easily by the action of dilute acids.
My foreign correspondents have now found, that by treating the said product
with formic aldehyde, it is transformed into a new compound, which represents
a very valuable remedy for intestinal diseases.
In order to illustrate the new process, the following example is given :-
EXAMPLE.
A solution of 175 kilos. by weight, of egg-albumen in 8 litres of water, is
mixed, at ordinary temperature, with a solution of 25 kilos. by weight of tannin
in 5 litres of water,' the well-known “tannin albuminate" being precipitated.
Subsequently 05 litres of a watery solution of formic aldehyde (containing
about 40 per cent. of CH₂O) is added to the reaction mixture, and the whole
mixture is then heated on a water-bath for about 10 hours, while continuously
stirring. During this operation, the "tannin-albuminate," being in the shape
of a viscous precipitate, is transformed into a granular mass, which
represents the new product. The reaction will be finished when a test portion
of the precipitate, filtered off, is found to be no longer immediately soluble in à
cold dilute caustic lye.
·
At this stage, the whole precipitate is filtered, washed with warm water, in
order to remove the free formic aldehyde still contained therein, and dried at
about from: 50 to 60 degrees Centigrade.
When dry and pulverized, the new compound is a light yellow powder, in-
soluble in water and in alcohol, ether, and benzene.
In dilute caustic 'lyes it does not dissolve immediately, but it is dissolved
therein after a prolonged treatment, being at the same time decomposed, with
the formation of tannic acid. The new product is not decomposed by dilutė
acids, and therefore it can be profitably used as an intestinal astringent which
has no 'detrimental action on the stomach.
On using other albumen compounds, such as serum albumen, vegetable
albumen, or the like, instead of egg albumen, the process proceeds in the same
manner.
"It may be remarked that my foreign correspondents do not intend to confine
themselves to the particulars given in this specification, as the example is
merely typical, and can be varied within wide limits.

page_text: Having now particularly described and ascertained the nature of the said in-
vention and in what manner the same is to be performed (as communicated to
me from abroad), I declare that what I claim is:-
"
1. The process for producing a new pharmaceutical compound, by allowing
formic aldehyde to act on tannin albuminate" obtainable from tannin and
albumens, substantially as herein before described.
2. As a new article of manufacture, the new product obtainable according to
the process herein before described and claimed.
3. The use of the new product claimed in the foregoing Claim 2, for thera-
peutical purposes.
Dated this 23rd day of February 1899
NEWTON & SON,
Agents for the Applicant.