IMPROVEMENTS IN PREPARING MEDICINAL SUBSTANCES AND COMPOUNDS FROM THE LIVERS OF COD AND OTHER SALT WATER FISH
Year: 1861

page_text: LETTERS PATENT to Charles Constant Joseph Guffroy, of Lille, in the
Empire of France, Merchant, for the Invention of "IMPROVEMENTS IN
PREPARING MEDICINAL SUBSTANCES AND COMPOUNDS FROM THE LIVERS OF COD
AND OTHER SALT WATER FISH."
Sealed the 24th January 1862, and dated the 29th July 1861.
PROVISIONAL SPECIFICATION left by the said Charles Constant Joseph
Guffroy at the Office of the Commissioners of Patents, with his Petition
on the 29th July 1861.
I, CHARLES CONSTANT JOSEPH GUFFROY, of Lille, in the Empire of France,
Merchant, do hereby declare the nature of the said Invention for "IMPROVE-
MENTS IN PREPARING MEDICINAL SUBSTANCES AND COMPOUNDS FROM THE LIVERS OF
COD AND OTHER SALT WATER FISH," to be as follows:-
My Invention consists in treating the watery liquid obtained from or
remaining after the extraction of oil from the liver of cod and other salt water
fish in manner hereafter explained.
In Letters Patent granted to me the 20th July 1860, No. 1764, I claimed
the extraction of a substance in a state of paste from the said watery liquid.
Now I take the watery liquid, and after separating the albumen (coagulated
by heat) therefrom, I add to it sugar, honey, or other saccharine matter,
subject the mixture to heat, and proceed in the manner ordinarily followed by
chemists in the manufacture of medicinal syrup. Or I take the watery liquid,
and instead of evaporating down to the state of paste, as described in the
Specification of my said former Letters Patent, I stop the evaporation before

page_text: the substance assumes a solid state. Or I form a liniment or ointment by
mixing with the watery liquid fatty or oily matters, and by exposing the
mixture to heat, care being taken to stir the mass while the watery particles
are being given off in the state of steam.
Again, I sometimes mix with the watery liquid alcohol or sulphuric ether;
whereupon a matter of a gummy nature, known as icthyoglycine, is preci-
pitated, which I separate, drive off the alcohol or the ether by heat, and' use as
a medicinal substance without further treatment. Or after the alcohol or
ether is driven off, I dissolve the icthyoglycine in water, and add sugar, honey,
or other saccharine matter to make a syrup of icthyoglycine.
With the watery liquid from which the ichthyoglycine has been precipitated
I form another medicinal syrup by mixing sugar or other saccharine matter, in
manner followed in making medicinal syrups.
SPECIFICATION in pursuance of the conditions of the Letters Patent, filed
by the said Charles Constant Joseph Guffroy in the Great Seal Patent
Office on the 29th January 1862.
TO ALL TO WHOM THESE PRESENTS SHALL COME, I, CHARLES
CONSTANT JOSEPH GUFFROY, of Lille, in the Empire of France, Merchant,
send greeting.
WHEREAS Her most Excellent Majesty Queen Victoria, by Her Letters
Patent, bearing date the Twenty-ninth day of July, in the year of our Lord
One thousand eight hundred and sixty-one, in the twenty-fifth year of. Her
reign, did, for Herself, Her heirs and successors, give and grant unto me,
the said Charles Constant Joseph Guffroy, Her special licence that I, the
said Charles Constant Joseph Guffroy, my executors, administrators, and
assigns, or such others as I, the said Charles Constant Joseph Guffroy, my
executors, administrators, and assigns, should at any time agree with, and
no others, from time to time and at all times thereafter during the term
therein expressed, should and lawfully might make, use, exercise, and vend,
within the United Kingdom of Great Britain and Ireland, the Channel
Islands, and Isle of Man, an Invention for "IMPROVEMENTS IN PREPARING
MEDICINAL SUBSTANCES AND COMPOUNDS FROM THE LIVERS OF COD AND OTHER SALT
WATER FISH," upon the condition (amongst others) that I, the said Charles
Constant Joseph Guffroy, my executors or administrators, by an instrument
in writing under my, or their, or one of their hands and seals, should par-
ticularly describe and ascertain the nature of the said Invention, and in what

page_text: manner the same was to be performed, and cause the same to be filed in
the Great Seal Patent Office within six calendar months next and immediately
after the date of the said Letters Patent.
NOW KNOW YE, that I, the said Charles Constant Joseph Guffroy, do
hereby declare the nature of my said Invention, and in what manner the
same is to be performed, to be particularly described and ascertained in and
by the following statement thereof, that is to say:
Under Letters Patent granted to me the 20th July 1860, No. 1764, I
claimed the extraction of a new medicinal substance in a state of tough paste
from the watery liquid obtained in or remaining after the extraction of oil
from the liver of cod and other salt water fish.
My present Invention consists in preparing from the same watery liquids
new medicinal substances and compounds, by treating them in manner here-
after explained.
Preparation No. 1.--I take the said watery liquid and free it from foreign
matters held in suspension by filtration or decantation. I subject it to
sufficient heat to coagulate the albumen, which I remove by skimming and
filtration or decantation. I add to the liquid, which then marks about ten
degrees Baumé, a quantity of distilled water in the proportion of 120 parts of
distilled water to 100 parts of the watery fish liquid. I allow the liquid to
coel, and add about 400 parts of sugar, honey, or other saccharine matter,
which, when dissolved, either cold or under a gentle heat, produces a medicinal
syrup of a pleasant taste, which may be flavoured or not by the addition of
essence of orange flowers or other aromatic substance. The syrup marks cold
about 36 degrees Baumé. I obtain a more concentrated syrup, thicker and
heavier, with the same proportions of the watery fish liquid, and of sugar or
honey, without adding any distilled water. And I obtain a more highly con-
centrated syrup by evaporating, under heat, the watery liquid before adding
the sugar or honey. In the two last cases I effect the intimate mixture of the
substances by trituration in a mortar. I am enabled to vary the medicinal
power of the syrup by altering the proportion of the watery fish liquid.
Preparation No. 2.-I take the watery liquid, and after separating the
albumen as before described, concentrate it by evaporation under a gentle heat
to various degrees, but I always stop the concentration before it reaches a state
of paste. This medicinal unsweetened syrup may be taken inwardly, enclosed
in capsules, or dissolved in wine, or it may be used for external applications.
Preparation No. 3.-I obtain a fatty syrup by adding to the watery fish
liquid, after the albumen has been separated from it, a fatty body or an oil,
but by preference, an oil of cod liver or other liver of sea water fish. I con-

page_text: centrate by evaporation under heat, stirring the whole time until a consistence
of syrup, more or less thick, or of soft paste has been attained. This syrup or
soft paste may be taken inwardly, encased in capsules, or it may be used for
external applications..
Preparations Nos. 4 and 5.-I mix with the watery liquid, freed from its
albumen, alcohol or ether, whereupon a matter of a gummy nature, known as
ichthyoglycine, is precipitated. I separate it from the liquid and drive off by
heat the alcohol or ether and water which may remain mixed with it, and
use it as a medicinal substance without further treatment. I also use the
watery liquid for medicinal purposes inwardly or outwardly, from which the
ichthyoglycine has been separated as aforesaid, and which contains all the
saline substances-non-precipitated. I call this preparation ichthyohalsine. I
use it either mixed with alcohol or ether, or freed from them by distillation.
Again, it may be more or less concentrated by gentle heat in a state of
syrup or paste.
Preparation No. 6.-I dissolve ichthyoglycine in water, and add sugar,
honey, or other saccbarine matter, and obtain syrup of ichthyoglycine by
operating in the manner usually-followed by-chemists in making syrups. This
ichthyoglycine syrup may, without detriment, be more or less concentrated
under heat, or it may be so highly concentrated as to form a paste for making
lozenges and other medicinal sweetmeats.
Preparation No. 7.-I take the liquid which I have herein-before named
ichthyohalsine, and mix with it, while cold, sugar, honey, or other saccharine
matter, to produce syrup of ichthyohalsine, more or less concentrated, in
manner and in the proportions directed under No. 1.
All the above preparatious should be kept in well-stoppered flasks, bottles,
or jars.
And having now described the nature of my said Invention, and in what
manner the same is to be performed, I declare that I claim the various
medicinal preparations herein-before described, obtained by treating the watery
liquid resulting from the livers of cod and other salt water fish substantially
iu manner herein-before described.
In witness whereof, I, the said Charles Constant Joseph Guffroy, have
hereunto set my hand and seal, this Twenty-fourth day of January,
One thousand eight hundred and sixty-two.
C. GUFFROY. (L.S.)