The Manufacture of a New Product from Piperidine.
Year: 1898

page_text: PROVISIONAL SPECIFICATION.
The Manufacture of a New Product from Piperidine.
JOHN THEODORE HEWITT, Professor of Chemistry in the East London Technical
College, People's Palace, Mile End Road, London, E., and of 65, Silverdale,
Sydenham, London, S.E., do hereby declare the nature of this invention to be as
follows:-
This invention relates to the manufacture of a new product from piperidine.
This new product is obtained by the action of salicylic acid or piperidine, the result
being a new body or salt, which is believed to possess valuable pharmacological &
therapeutical properties. This new body is formed by the action of piperidine on
salicylic acid with or without the presence of a solvent such as water, alcohol, ether,
benzene or other suitable solvent. For example 138 parts (1 molecule) of salicylic
acid are mixed with about 400 parts of water & then 85 parts (1 molecule)
piperidine are added. The result is a clear solution, which on evaporation leaves a
yellowish syrup, that rapidly crystallizes on cooling or rubbing. The salt thus
obtained may be recrystallized from a suitable solvent (such as water, alcohol, ether,
benzene etc.) and forms white prisms melting at 113-114° C, which are easily
soluble in water, alcohol, ether, insoluble in petroleum ether. The new substance
may similarly be obtained by dissolving the piperidine in ether or petroleum ether
or other suitable solvent and the salicylic acid in ether or a mixture of ether and
petroleum-ether, alcohol or other suitable solvent. When using a petroleum ether
solution the body is first precipitated in the shape of a light yellowish oil, which
rapidly crystallizes on rubbing with a glass rod.
TX
C Contam To
The Manufacture of a New Product from Piperidine.
JOHN THEODORE HEWITT, Professor of Chemistry in the East London Technical
College, People's Palace, Mile End Road, London, E., and of 65, Silverdale,
Sydenham, London, S.E., do hereby declare the nature of this invention and in
what manner the same is to be performed, to be particularly described and
ascertained in and by the following statement :-
This invention relates to the manufacture of a new product from piperidine.
This new product is obtained by the action of salicylic acid on piperidine, the result
being a new body or salt, which is believed to possess valuable pharmacological &
therapeutical properties. This new body is formed by the action of piperidine on
salicylic acid with or without the presence of a solvent such as water, alcohol, ether,
T

page_text: benzene or other suitable solvent.
For example, 138 parts (1 molecule) of salicylic
acid are mixed with about 400 parts of water & then 85 parts (1 molecule)
piperidine are added. The result is a clear solution, which on evaporation leaves a
yellowish syrup, that crystallizes on cooling or rubbing. The salt thus obtained may
be recrystallized from a suitable solvent (such as water, alcohol, ether benzene, &c.)
and forms white prisms melting at 113-114° C., which are easily soluble in water,
alcohol & ether, but insoluble in petroleum ether. The new substance may
similarly be obtained by dissolving the piperidine in ether or petroleum ether or other
suitable solvent, & the salicylic acid in ether or a mixture of ether & petroleum ether,
alcohol or other suitable solvent. When using a petroleum ether solution the body
is first precipitated in the shape of a light yellowish oil, which rapidly crystallizes on
rubbing with a glass rod.
Having now particularly described & ascertained the nature of my said
invention, and in what manner the same is to be performed, I declare that what
I claim is
1. The manufacture of a new product from piperidine by treating piperidine either
alone or dissolved in a suitable solvent, with salicylic acid (the latter also being
employed either as such, or in the presence of a suitable solvent) substantially as
hereinbefore described.
2. As a new product salicylate of piperidine.