which are not Affected by the Stomach Juices but Dissolve in the Intestines.
Year: 1885

page_text: which are not Affected by the Stomach Juices but Dissolve
in the Intestines.
I, PETER JENSEN Fel. Inst. P. A. of 33 Chancery Lane in the County of
Middlesex do hereby declare the nature of this invention (a communication to
me from abroad by George Gustav Pohl of Schönbaum near Danzig Prussia
Chemist) to be as follows:-
It is well known that gelatine and wafer capsules whereby medicaments are
introduced into the human body are dissolved by the stomach juices. But in
intestinal diseases especially infectious ones it is of importance that the medicaments
whether in the liquid or solid or dry form should be applied in large doses directly
in the intestine. As however the capsules heretofore made dissolved already in
the stomach a direct application in the intestine was impossible.
Now according to this invention the aforesaid defect is overcome by making the
capsules of a special composition having the property of being insoluble in the
stomach juice but soluble in the intestine.
This composition is made as follows:-Keratine (purified hard material) is first
dissolved in liquid ammonia concentrated as much as possible; after filtration
through spun glass the solution is boiled down to a syrup consistency until the
smell of ammonia is almost gone. Best shellac is then by maceration with ether
freed from its wax like substance, and four parts of the remaining resin together
with one part borax and distilled water heated till dissolved. This solution having
been filtered is likewise boiled down to a syrup consistency. Equal parts of the
two syrup liquids are then taken and mixed and heated with the admixture of a
minute quantity of ammoniacal colophone solution. The so produced composition
is then made into capsules in the same manner as with a gelatine solution.
Such capsules have as stated the property of not dissolving in the stomach but
to dissolve entirely in the intestine and thus make it possible to apply medicaments

page_text: and especially antiseptics directly in the intestine which is of the greatest importance
in intestinal diseases especially when infectious.
These capsules are also applicable in such cases in which medicaments are to be
administered which the stomach ill can bear such as extractum filicis or balsam
⚫ copaivae.
BREWER & JENSEN,
For the Applicant.
which are not Affected by the Stomach Juices but Dissolve
in the Intestines.
I, PETER JENSEN Fel. Inst. P. A. of 33 Chancery Lane in the County of
Middlesex do hereby declare the nature of this invention a communication to me
from abroad by George Gustav Pohl of Schönbaum near Danzig Prussia Chemist
and in what manner the same is to be performed, to be particularly described and
ascertained in and by the following statement:-
It is well known that gelatine and wafer capsules whereby medicaments are
introduced into the human body are dissolved by the stomach juices. But in
intestinal diseases especially infectious ones it is of importance that the medicaments
whether in the liquid or solid or dry form should be applied in large doses directly
in the intestine. As however the capsules heretofore made dissolved already in
the stomach a direct application in the intestine was impossible.
Now according to this invention the aforesaid defect is overcome by the making
capsules of a special composition having the property of being insoluble in the
stomach juice but soluble in the intestine.
This composition is made as follows:-Keratine (purified horn material) is first
dissolved in liquid ammonia concentrated as much as possible; after filtration
through spun glass the solution is boiled down to a syrup consistency until the
smell of ammonia is almost gone. Best shellac is then by maceration with ether
freed from its wax-like substance, and four parts of the remaining resin together
with one part borax and distilled water heated till dissolved. This solution having
been filtered is likewise boiled down to a syrup consistency. Equal parts of the
two syrup liquids are then taken and mixed and heated with the admixture of a
minute quantity of ammoniacal colophone solution. The so produced composition
is then made into capsules in the same manner as with a gelatine solution.

page_text: Such capsules have as stated the property of not dissolving in the stomach but
to dissolve entirely in the intestine and thus make it possible to apply medicaments
and especially antiseptics directly in the intestine which is of the greatest importance
in intestinal diseases, especially when infectious.
These capsules are also applicable in such cases in which medicaments are to be
administered which the stomach ill can bear such as extractum filicis or balsam
copaivae.
Having now particularly described and ascertained the nature of my said
Invention, and in what manner the same is to be performed, I declare that what
I claim as the invention communicated to me is:-
syrup
For the purpose of obtaining medicinal capsules which shall remain undissolved
in the stomach but which are thoroughly soluble in the intestines, the production
of capsules from a mass which consists of a mixture of firstly, Keratine (purified
horn material) dissolved in liquid ammonia filtered and boiled down to
consistency, secondly, shellac freed from its wax together with borax and distilled
water, made into a solution, and boiled down to a syrup consistency, and thirdly,
a very small amount of ammoniacal Colophone solution, all substantially as set
forth.