Improvements relating to the Production of Narceine-sodium- sodium-salicylicum.
Year: 1892

page_text: Date of Application, 27th Apr., 1892
Complete Specification Left, 23rd Jan., 1893-Accepted, 11th Mar., 1893
PROVISIONAL SPECIFICATION.
Improvements relating to the Production of Narceine-sodium-
sodium-salicylicum.
We, Dr. ERNST KAUDER, of 86' Kiesstrasse, Chemist, and Dr. LOUIS MERCK,
Proprietor of the firm of E. Merck, of 7 Rheinstrasse, both of Darmstadt, in the
Empire of Germany, do hereby declare the nature of this invention to be as
follows:-
The opium alkaloid narceine dissolves with dificulty; its salts have a powerful
acid reaction and decompose moreover in contact with water into free acid and
basic salts dissolving with difficulty. These properties affect the medicinal use of
narceine in an injurious manner.
The present invention has for its object to produce a compound containing
narceine and which does not possess these deleterious properties. Such a compound
has been found to be the new substance narceine-sodium-sodium-salicylicum which
is easily soluble in cold water and, when thus dissolved does not decompose in the
manner hereinbefore stated, and hence does not precipitate either narceine or a basic
narceine salt.
This compound is suitably prepared by pouring upon about ten parts by weight
of narceinum puruin about thirty parts by weight of water and gently heating the
same, soda lye being introduced until all the narceine has been dissolved. To this
are added, either before, during or after the addition of the soda lye, about nine
parts by weight of sodium salicylicum either alone or as a concentrated aqueous
solution, the whole being evaporated as quickly as practicable at a very moderate
heat. The residue obtained, which may be suitably pulverized, is narceine-sodium-
sodium-salicylicum; and constitutes a slightly hygroscopic, greyish white substance
containing about fifty per cent. of narceine.
Experiments made with the new substance have shown it to be a mild narcotic
without any injurious secondary effects, which is very valuable for the medical
treatment of children's diseases, as a narcotic with such properties has not hereto-
fore been known. Moreover, in cases of bronchitis and similar diseases it is
extremely useful as a sedative. By the present invention narceine is not only
obtained in a state of solution, but also in combination with salicylic acid and with
sodium-salicylicum, which considerably increases its usefulness.
Dated this 27th day of April 1892.
HASELTINE, LAKE & Co.,
45, Southampton Buildings, London, Agents for the Applicants.
COMPLETE SPECIFICATION.
Improvements relating to the Production of Narceine-sodium-
sodium-salicylicum.
We, Dr. ERNST KAUDER, of 86 Kiesstrasse, Chemist and Dr. LOUIS MERCK,
Proprietor of the firm of E. Merck, of 7 Rheinstrasse, both of Darmstadt, in the
Empire of Germany do hereby declare the nature of this invention and in what
manner the same is to be performed to be particularly described and ascertained
in and by the following statement :-
The opium alkaloid narceine dissolves with difficulty; its salts have a powerful
acid reaction and moreover decompose in contact with water into free acid and basic
salts dissolving with difficulty. These properties affect the medicinal use of
narceine in an injurious manner.

page_text: The present invention has for its object to produce a compound containing
narceine, and which does not possess these deleterious properties.
This compound consists of narceine-sodium-sodium-salicylicum which is easily
soluble in cold water and when thus dissolved does not decompose in the manner
herein before stated, and hence does not precipitate either narceine or a basic
narceine salt.
This compound is suitably prepared by pouring upon, about ten parts by weight
of narceinum purum, about thirty parts by weight of water and gently heating the
same, soda lye being introduced until all the narceine has been dissolved. To
this are added about nine parts by weight of sodium salicylicum either alone or
88 a concentrated aqueous solution, either before, during or after the addition
of the soda lye, the whole being evaporated as quickly as practicable at a very
thoderate heat. The residue obtained which may be suitably pulverized, is narceine-
sodium-sodium-salicylicum, and constitutes a slightly hygroscopic greyish white
substance containing about fifty per cent. of narceine.
It has been shown by experiments made with the new substance that the same
is a mild narcotic without any injurious secondary effects which is very valuable for
the medical treatment of children's diseases, as a narcotic with such properties has
not heretofore been known. Moreover in cases of bronchitis and similar diseases it
is extremely useful as a sedative.
By the present invention narceine is not only obtained in a state of solution but
also in combination with salicylic acid and with sodium-salicylicum, which
considerably increases its usefulness.
Having now particularly described and ascertained the nature of our said inven-
tion and in what manner the same is to be performed we declare that what we
claim is :-
First. The above described method of producing narceine-sodium-sodium-
salicylicum, which consists in bringing sodium in the presence of water in contact
with narceine and in the presence of, or simultaneously or subsequently adding,
sodium-salicylicum.
Second. As an industrial and commercial product, and as a new medicament,
narceine-sodium-sodium-salicylicum which forms a slightly hygroscopic, greyish
white substance easily soluble in cold water, and which contains narceine and sodium
salicylicum.
Dated this 23rd day of January 1893.
Dated this 23rd day of January 1893.
HASELTINE, LAKE & Co.,
45, Southampton Buildings, London, W.C., Agents for the Applicants
HASELTINE, LAKE & Co.,
45, Southampton Buildings, London, W.C., Agents for the Applicants