Year: 1898

page_text: utt Cinorat nyurate, by anowing the said Dodies to act one
upon the other in the presence of strong acids, such as sulphuric acid or
the like.
In order to illustrate the new process, the following example is given, the parts
being by weight,
EXAMPLE.
To a solution prepared by dissolving 10 parts of tannin in 10 parts of hot water,
4 litres (in case the parts are kilos by weight) of sulphuric acid (containing about
70 per cent. of H2SO₁) are added whilst stirring. By means of this operation, the
whole tannin contained in the mixture is separated in the shape of a viscous paste.
Subsequently, a concentrated solution of 25 parts of chloral hydrate is poured into
the mixture while energetically stirring, the pasty precipitate being thus re-dissolved.
The resulting solution is heated with occasional stirring for several hours at from
70 to 80 degrees Centigrade. After a while, a pulverous precipitate begins to
separate, which by and by increases. Finally, the whole liquid is transformed into
a greyish-brown pasty mass. When the reaction is finished (which will be the
case after about 10 hours), the precipitate is separated from the liquid by filtration,
and by subsequently washing the residue remaining on the filter with cold water.
Finally, this residue, which represents the new condensation product, is dried at low
temperatures.
The new product represents a greyish-brown amorphous powder, which dissolves
with difficulty in cold water, but with comparative readiness in warm water. On
cooling the warm watery solution, the new compound is again precipitated in the
shape of an amorphous powder. On the addition of a small quantity of a ferric
chloride solution, the watery solution of the new product assumes an olive-green
color, whilst it is not changed on the addition of potassium cyanide. The new
compound is soluble in alcohol, insoluble in ether, chloroform, benzene, and acetic
ether. By alkalies it is easily dissolved, yielding an intense yellowish-brown color.
When boiled with soda-lye and aniline, an intense smell of isonitrite is
produced.
When heated above 250 degrees Centigrade, is is decomposed without exhibiting
a melting point.

page_text: According to the researches of my foreign correspondents, the new product repre-
sents a valuable remedy for the purposes of dermatology..
It may be remarked that my foreign correspondents do not limit themselves to
the particulars given in the above example, as this is merely typical, and can be
varied within wide limits, without altering thereby the nature of the present
invention.
Thus, for instance, the extracts of all materials containing tannic acids, such as
the extracts from ratauhia, catechu, oak-bark, quebracho, or the like, can be
employed instead of tannin.
NEWTON & SON,
Agents for the Applicant.
EXAMPLE.
To a solution prepared by dissolving 10 parts of tannin in 10 parts of hot water,
4 litres (in case the parts are kilos by weight) of sulphuric acid (containing about
70 per cent. of H₂SO₁) are added whilst stirring. By means of this operation,
the whole tannin contained in the mixture is separated in the shape of a viscous
paste. Subsequently, a concentrated solution of 2.5 parts of chloral hydrate is
poured into the mixture while energetically stirring, the pasty precipitate being
thus re-dissolved. The resulting solution is heated, with occasional stirring, for
several hours, at from 70 to 80 degrees Centigrade. After a while a pulverous
precipitate begins to separate, which by and by increases. Finally, the whole
liquid is transformed into a greyish-brown pasty mass. When the reaction is
finished (which will be the case after about 10 hours), the precipitate is separated
from the liquid by filtration, and by subsequently washing the residue remaining
on the filter with cold water. Finally, this residue, which represents the new
condensation product, is dried at low temperatures.
On
The new product represents a greyish-brown amorphous powder, which dissolves
with difficulty in cold water, but with comparative readiness in warm water.
cooling the warm watery solution, the new compound is again precipitated in the shape
of an amorphous powder. On the addition of a small quantity of a ferric chloride
solution, the watery solution of the new product assumes an olive-green color, but
it shows no change on the addition of potassium cyanide. The new compound is
soluble in alcohol, insoluble in ether, chloroform, benzene, and acetic ether. By
alkalies it is easily dissolved, yielding an intense yellowish-brown color.
boiled with soda lye and aniline, an intense smell of isonitrile is produced.
When

page_text: When heated above 250 degrees Centigrade, it is decomposed without exhibiting
a melting point.
According to the researches of my foreign correspondents, the new product
represents a valuable remedy for the purposes of dermatology.
It may be remarked that my foreign correspondents do not limit themselves to
the particulars given in the above example, as this is merely typical, and can
be varied within wide limits, without altering thereby the nature of the present
invention.
It may be here remarked that instead of chloral hydrate, all substances can be
employed which are capable of yielding chloral hydrate, such as chloral, chloral
alcoholate, chloral amide, or the like.
Having now particularly described and ascertained the nature of the said inven-
tion and in what manner the same is to be performed, as communicated to me
from abroad, I declare that what I claim is :-
1. The process for producing a new condensation product by allowing tannin to
act, in the presence of a strong acid, on chloral hydrate, or such substances
as are capable of yielding chloral hydrate, substantially as herein before
described.
2. As a new article of manufacture, the new condensation product hereinbefore
described.
3. The use of the new product herein before described and claimed for medical
purposes.
Dated this 26th day of October 1898.