Year: 1898

page_text: A communication from REINHARD WAGNITZ, Merchant, of 6, Charitestrasse,
Berlin, in the Empire of Germany..
I, ALFRED JULIUS BOULT, of 111, Hatton Garden, in the County of Middlesex,
Chartered Patent Agent, do hereby declare the nature of this invention to be as
follows:-
It is well known that anhydrous chloral (trichloracetaldehyde) with water
forms chloral hydrate, and, with alcohol, chloral alcoholate, the reaction being
accompanied by development of heat. It is also well known that chloral combines
with substances which readily give off water, such as for instance, hydrate of
magnesium, and also with substances containing a hydroxyl group (HO) such
as, for instance, menthol, terpineol, phenol, and with substances which contain
several hydroxyl groups, such as, for instance, glycerine.
All these substances combine directly with chloral becoming heated during
the process, and these products, compared with pure chloral, have scarcely any
antiseptic properties.
:-
The objects of this invention are as follows:-
1st. The manufacture of volatile chloral combinations, readily soluble in
alcohol, such, for instance chloral-bromine-menthol or chloral-iodine-menthol, or
chloral-phenol-menthol.
2nd. The manufacture of heavy or non-volatile chloral combinations soluble in
water, such as, for instance, boracic acid, salicylic acid, lactose, dissolved in
glycerine and then combined, with alcohol, for instance chloral-boracic acid-
glycerine; chloral-salicylic acid-glycerine; chloral-lactose-glycerine menthol.
3rd. The combination of the chloral compounds mentioned, with magnesium
hydrate or hydrated magnesium carbonate.
The new volatile chloral combinations, readily soluble in alcohol, are produced
by causing, first, say one equivalent of bromine iodine or phenol to react on one
equivalent of menthol or terpineol or both. Each one equivalent of the menthol
or terpineol employed then combines with one equivalent of chloral.
The new heavy or non-volatile chloral combinations soluble in water, are pro-
duced by dissolving by heating it for a long time-first, say, boracic acid,
salicylic acid, lactose, etc. in glycerine, if desired until a saturated solution is
obtained, and then by causing one or more equivalents of chloral to react on each
one equivalent of glycerine employed.
The chloral combinations mentioned under (1) and (2) when mixed with mag-
nesium hydrate or hydrated magnesium carbonate combines with it the reaction
causing a development of heat. If more magnesium hydrate or hydrated mag-
nesium carbonate is used than can combine with the chloral compounds, a powder,

page_text: which has a constant composition, can be prepared from the new chloral com-
pounds with the magnesium hydrate or carbonate.
Dated this 7th day of September 1898.
BOULT & WADE,
Agents for the Applicant.
A communication from REINILARD WAGNITZ, Merchant, of 6, Charitestrasse,
Berlin, in the Empire of Germany.
I, ALFRED JULIUS BOULT, Chartered Patent Agent, of 111, Hatton Garden, in
the County of Middlesex, do hereby declare the nature of this invention, and
in what manner the same is to be performed, to be particularly described and
ascertained in and by the following statement :-
The present invention relates to a process of production of new chloral com-
binations, which possess extraordinary disinfecting properties.
It is known that anhydrous chloral (trichloraldehyde) combines with water or
with alcohol, forming chloral-hydrate, and chloral-alcoholate respectively, the
reaction being accompanied by development of heat, likewise it is a known fact,
that chloral will combine with bodies which readily yield water, or which include
hydroxyl groups, such as for instance, glycerine.
When such bodies are brought together with chloral direct additional products
are formed, which have scarcely any antiseptic properties as compared with pure
chloral.
The object of the present invention is a process for the production of chloral
combinations which have very great antiseptic properties.
For this purpose boracic acid, or salicylic-acid, or milk sugar, or the like, is
dissolved in say glycerine up to the point of saturation and heated until all the
water is driven off from the solutions. Then one or more equivalents of chloral
are added to every equivalent of glycerine used. This will yield double combina-
tions, clear in appearance and of syrup-like consistency, at ordinary temperature
of chloral with boracic-acid, or salicylie-acid, or milk sugar, which are non-
volatile, or nearly so, are readily soluble in water, and are possessed as already
stated, of extraordinary antiseptic properties.
By way of example the following application of the process may be given.
Heat 150 parts of glycerine, free from water, with 75 parts of milk sugar, or
boracic-acid, until a perfect dissolution is obtained, whereby all the water con-
tained in the milk sugar or in the boracic-acid is driven off. This solution of
milk sugar, or of boracic-acid in glycerine is then allowed to cool down to
say 40° C. and exposed to the action, while being energetically stirred, of 200
parts of chloral. The combination takes place under the evolution of heat and
after cooling the result is a clear thick liquid readily soluble in water.
The final product may be considered as a combination of the three bodies which
were caused to react on each other, viz. of milk sugar, or boracic-acid as the case
may be, with glycerine and with chloral, inasmuch as a solution in ready-made
chloral-glycerine of milk sugar, or of boracic-acid cannot be obtained. Boracic-
acid and the like may be heated for days in the above proportions, or in any
other, without producing a combination, or a dissolution. Nor can the possi
bility be admitted that when chloral is caused to react on boracic-acid or.

page_text: the like dissolved in glycerine, a retrograde decomposition takes place, for if that
were so, in time, pure boracic-acid or milk sugar would be eliminated.
Salicylic acid behaves in exactly the same manner, as the boracic-acid or milk
sugar chosen for the example, and all the remarks applied to these acids also
apply to the former substance.
New combinations of chloral which are volatile and easily soluble in alcohol
may be obtained if the process is modified in the following manner.
In the first instance combinations of bromine, or of iodine with an alcohol of
the terpene series; such as menthol or terpineol, or with both together, are
produced, and then treated with chloral in the proportion of one equivalent of
chloral to every equivalent of menthol or terpineol that had been used. In this
way combinations are obtained which are volatile, soluble in alcohol and
possessed of extraordinary antiseptic power. As an example the following
special application may be given.
156 parts of menthol are caused to react on 80 parts of bromine or on 150 parts
of iodine. Menthol-bromine being a very volatile body, the bromine process must
be carried out very slowly and the liquids must be kept cool, while in the case
of iodine and menthol the process is with advantage accelerated by a slight
heating.
This iodine, or bromine combination with menthol, is next treated with from
100 to 150 parts of pure chloral. Much heat is thereby evolved, almost as much
as when pure menthol is mixed with pure chloral.
The final product when treated with alcohol evolves no heat, thus proving that
a complete combination of the bromine-menthol, or of the iodine menthol has
taken place with the chloral: On the other hand, if a combination of menthol
and chloral be mixed with bromine, or iodine no solution is possible of the
latter in the above quantities. There is also no heat generated when bromine or
iodine is mixed with chloral-menthol which is a proof that the combination is
different from that produced by treating bromine-menthol with chloral.
A further proof that a real combination of the three bodies, iodine, menthol
and chloral is formed, is furnished by the fact that the product obtained by this
new process is soluble in any quantity in alcohol where it becomes almost totally
decolourised if left standing for some time, while, on the contrary, when iodine
is added to already formed chloral-menthol the colour of the iodine remains
unchanged if left standing for a long time.
To produce the said combinations in the form of powder they may be mixed with
magnesia hydrate powder, or with magnesium hydrocarbonate-powder, with
which they form, under development of heat an equally stable chemical com-
bination.
Having now particularly described and ascertained the nature of the said
invention, as communicated to me by my foreign correspondent, and in what
manner the same is to be performed, I declare that what I claim is:
-
2. A process for the production of new chloral combinations, characterised by
a body or bodies to be combined with chloral, according to their nature or
quality, being first dissolved in an alcohol of the terpene series such as menthol,
or terpineol, or in a mixture of both, or in glycerine, and the solution afterwards
treated with chloral, substantially as described.
2. A process for the production of new chloral combinations, characterised by
a substance such as boracic-acid, milk sugar, salicylic-acid or the like being
dissolved in glycerine, then heated until all the contained water is driven off, and
treated with chloral, thereby producing double combinations from the solvent,
the dissolved body and chloral, substantially as described.
3. A process for the production of new volatile chloral combinations, soluble in
alcohol, characterised by iodine, or bromine, being first caused to combine with
menthol or with terpineol or with a mixture of both. which combinations are
afterwards treated with chloral, substantially as described.

page_text: 4. A modification of the processes described consisting in adding to the product
obtained magnesium hydrate powder or magnesium hydrocarbonate powder or
equivalent to form a chloral combination in powder form substantially as
described.
5. The new chloral combinations substantially as described.