A Method of Dissolving Iodine in Mineral Oils.
Year: 1897

page_text: Date of Application, 26th Feb., 1897
Complete Specification Left, 27th Oct., 1897-Accepted, 27th Nov., 1897
[Communicated from abroad by FRIEDRICH WILHELM KLEVER, of 6 Brandenburgerstrasse
Cologne-on-the-Rhine, in the Empire of Germany.]
A Method of Dissolving Iodine in Mineral Oils.
I, HENRY HARRIS LAKE, of the Firm of Haseltine, Lake & Co., Patent Agents,
45 Southampton Buildings, in the County of Middlesex, do hereby declare the nature
of this invention to be as follows:-
It has heretofore not been possible to produce permanent solutions of iodine in
heavy mineral oils. In like manner it was impracticable to bring iodine together
with oleic acid for the purpose of medicinal use, because the oleic acid combines
chemically with the iodine, whereby the therapeutic action of the iodine is lost,
because it acts only in the free uncombined state.
A permanent solution of iodine in mineral oils with or without an addition of fats
or oleic acid, which is extremely well adapted for medicinal purposes, is manufactured
in the following manner:
pressure.
I mix the mineral oil to be treated, with carriers of oxygen, especially alkalies, and of
the latter preferably caustic alkalies or alkaline carbonates, either in the solid state
or in solutions, use being preferably made in the latter case of as concentrated
solutions as practicable. The mixture is heated in a vessel, stirring if desired,
whilst at the same time I introduce oxygen in any suitable form, if necessary under
The introduction of oxygen has for its object to limit as much as possible
the extent to which alkalies are added. If pure oxygen is used it will be expedient
to produce the same from the compressed gas of commerce. The quantity of
alkalies added may be varied between two and seven per cent. of sodium or
potassium hydroxide, when adding solutions the quantity of the same must
correspond to the stated proportion of alkaline hydroxide. It is advisable to use oils
which do not necessitate such a large addition of alkali. It is advantageous to select
oils in which the addition amounts to from two to three percent. of alkaline hydroxide
or solutions containing a corresponding amount. Many mineral oils cannot be
converted to the form required for the present purpose by the described mode of
treatment. In such cases it is advisable to add fat oils or oleic acids to the mineral
oils treated with alkalies. I choose advantageously mineral oils in which the
addition of fatty oils or fatty acids need not exceeed twenty percent. In the
mineral oils mixed with fatty oils or fatty acids it is expedient to employ, in lieu of
the addition of pure caustic alkalies or pure solutions of the same, an addition
of ammonia or an addition of both substances in the proportion stated for the addition
of caustic alkalies.
To prevent the liquid which forms the finished product becoming too thick an
addition of alcohol up to two percent. is allowed.
The quantity of the requisite addition, the time of the heating and the necessary
pressure vary according to the nature of the oils which are employed. The
ecessary pressure varies according to the nature of the mineral oils within wide limits
between seven and thirty atmospheres. The temperature may be raised up to
Γνικής

page_text: 200 degrees Centrigrade. The conditions should be such that the product obtained
gives with water an emulsion, which is determined by taking a sample and examining
the behaviour of the sample towards water.
Sometimes the reception of the oxygen on the part of the mineral oils mixed with
fatty oils or with oleic acids may also be effected with air by simply shaking the same
after they have been mixed with the aforesaid additions. Of the mineral oils the
so-called heavy mineral oils having a specific gravity of 0.890 and 0.900, and also
the purified paraffin oils and further the so-called vaseline oils have proved to be
suitable for the present purpose.
The dissolution of the iodine in the solvent takes place in the known manner by
digestion and the like, if necessary under pressure, under the conditions hereinbefore
set forth. It is advantageous to use a quantity of 6 per cent. of iodine, but this
quantity may also be varied.
Dated this 26th day of February 1897.
I, HENRY HARRIS LAKE, of the Firm of Haseltine, Lake & Co., Patent Agents,
45 Southampton Buildings, in the County of Middlesex, do hereby declare the nature
of this invention and in what manner the same is to be performed, to be
particularly described and ascertained in and by the following statement :-
It has heretofore not been possible to produce permanent solutions of iodine in
heavy mineral oils. In like manner it was impracticable to bring iodine together
with oleic acid for the purpose of medicinal use, because the oleic acid combines
chemically with the iodine whereby the therapeutic action of the iodine is lost,
because it acts only in the free uncombined state.
A permanent solution of iodine in mineral oils with or without an addition of fats
or oleic acid, which is extremely well adapted for medicinal purposes, is manu-
factured in the following manner:-
I mix the mineral oil to be treated, with carriers of oxygen, especially alkalies,
and of the latter preferably caustic alkalies or alkaline carbonates, either in the solid
state or in solutions, use being preferably made in the latter case of as concentrated
solutions as practicable. The mixture is heated in a vessel, stirring if desired,
whilst at the same time I introduce oxygen in any suitable form, if necessary under
pressure. The introduction of oxygen has for its object to limit as much as possible
the extent to which alkalies are added. If pure oxygen is used it will be expedient
to produce the same from the compressed gas of commerce. The quantity of alkalis
added may be varied between two and seven per cent. of sodium or potassium
hydroxide when adding solutions the quantity of the same must correspond to the
stated proportion of alkaline hydroxide. It is advisable to use oils which do not
necessitate such a large addition of alkali. It is advantageous to select oils in which
the addition amounts to from two to three per cent. of alkaline hydroxide or solutions
containing a corresponding amount. Many mineral oils cannot be converted to the
form required for the present purpose by the described mode of treatment. In such
cases it is advisable to add fat oils or oleic acids to the mineral oils treated with
alkalies. I choose advantageously mineral oils in which the addition of fatty oils
or fatty acids need not exceed twenty per cent. In the mineral oils mixed with

page_text: fatty oils or fatty acids it is expedient to employ in lieu of the addition of pure
caustic alkalies or pure solutions of the same, an addition of ammonia or an addition
of both substances in the proportion stated for the addition of caustic alkalies.
To prevent the liquid which forms the finished product becoming too thick an
addition of alcohol up to two per cent is allowed.
The quantity of the requisite addition, the time of the heating and the necessary
pressure vary according to the nature of the oils which are employed. The
necessary pressure varies according to the nature of the mineral oils within wide
limits between seven and thirty atmospheres. The temperature may be raised up
to 200 degrees centigrade. The conditions should be such that the product obtained
gives with water an emulsion, which is determined by taking a sample and
examining the behaviour of the sample towards water.
Sometimes the reception of the oxygen on the part of the mineral oils mixed with
fatty oils or with oleic acids may also be effected with air by simply shaking the
same after they have been mixed with the aforesaid additions. Of the mineral oils
the so-called heavy mineral oils having a specific gravity of 0.890 and 0.900 and
also the purified paraffin oils and further the so-called vaseline oils have proved
to be suitable for the present purpose.
The dissolution of the iodine in the solvent takes place in the known manner
by digestion and the like, if necessary under pressure under the conditions herein-
befor set forth. It is advantageous to use a quantity of 6 per cent. of iodine, but
this quantity may also be varied.
Having now particularly described and ascertained the nature of my said
invention and in what manner the same is to be performed, as communicated
to me by my foreign correspondent, I declare that what I claim is :-
1. A process for the manufacture of a solution of iodine in mineral oils
characterised by the fact that heavy mineral oils of the specific gravity of 890 to
900, if desired with the addition of fatty oils or oleic acid mixed with alkalies,
under pressure if necessary, are oxidised and then in the resultant mass the iodine
is dissolved.
2. As a new product, the solution of iodine in mineral oil described in
claim 1.
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1
HASELTINE, LAKE & Co.,
45, Southampton Buildings, London, W.C., Agents for the Applicant.