Year: 1887

page_text: Date of Application, 10th Jan., 1887.
Complete Left, 11th Feb., 1887.
Complete Accepted, 15th Apr., 1887.

page_text: Improvements in the Manufacture of Coated Pills and Capsules.
I, WILLIAM LAMOND HOWIE of Eccles, in the county of Lancaster, Pharmaceutical
Chemist do hereby declare the nature of this invention and in what manner the same
is to be performed, to be particularly described and ascertained in and by the following
statement:-
The object of my invention is to impart a sweet taste to the coat or covering of tale
(mineral silicate of magnesia) or gelatine, or resin, or other substance applied to pills
(otherwise known by such names as pilules, paroules, granules, or pellets) and to the
substance of which capsules are formed, for the purpose of covering or disguising the
nauseous taste of medicines administered in these forms.
For this purpose I mix one part of the substance known as saccharine, otherwise
known as ortho-sulphamine-benzoic acid, or benzoic sulphinide, or benzoylsulphonic-
imide, or coal-tar saccharine, or Fahlberg's saccharine, and hereinafter referred to as
"saccharine"; by whatsoever process produced, or any of its constituents, or salts, or
combinations, or more or less according to the degree of sweetness desired, preferably
dissolved in a sufficiency (about 60 parts) of ether, alcohol or other volatile solvent,
with 200 parts of the lengated tale, or other substance, and having dried the mixture
if the saccharine has been added in solution, the sweetened tale or other substance is
used in the process of pill coating as commonly practiced in the art of pharmacy.
Or I mix or dissolve one part of saccharine or more or less according to the degree
of sweetness desired, in 500 parts of the mucilage, or adhesive solution with which the
tale, or sweetened talc, or other substance is applied to the pills in the process of
coating as practiced in the art of pharmacy.
Or I mix or dissolve one part of saccharine, or more or less according to the degree
of sweetness desired with 200 parts of gelatine, or other such substance & sufficient
water or other solvent (preferably about 500 parts) to form a sweet solution, into
which the pills are dipped according to the process of coating with gelatine practiced
in the art of pharmacy.
Or I mix or dissolve one part of saccharine, or more or less according to the degree
of sweetness desired with 500 parts of varnish, composed of sandarach, or other
resinous gum, and ether, or alcohol, or other solvent, or a mixture of two or more of
such gums or solvents (for example, one part of gum sandarach and 5 parts of ether)
and apply this sweetened varnish to the pills according to the process of varnishing,
or coating with resin, practiced in the art of pharmacy, or I apply such a varnish or
solution of saccharine to the pills, before, or during, or after the process of coating
with tale, or gelatine, or other substance as hereinbefore referred to.
Or I roll the pills in process of being coated with tale, or gelatine, or resin, or
other substance in saccharine, or in a mixture of saccharine and other substance.
Or I roll the pills after being coated with talc, or gelatine, or resin, or other
substance in saccharine, or in a solution of saccharine, or I use a combination of any
two or more of the hereinbefore mentioned processes.

page_text: Or I mix or dissolve one part of saccharine, or more or less according to the degree
of sweetness desired with 140 parts of gelatine or other such substance in sufficient
water or water and glycerine, or other solvent, (for example 600 parts of water and
70 parts of glycerine) into which the moulds are dipped for the purpose of forming
the hollow envelopes or capsules, to be thereafter filled with medicinal powders, or by
means of a proper nozzle or syringe with liquid medicinal agents according to the
process of capsule making as practiced in the art of pharmacy.
Having now particularly described and ascertained the nature of my said invention
and in what manner the same is to be performed, I declare that what I claim is :-
1st. The herein before described methods of manufacturing a sweet coat, covering,
envelope, or capsule for medicinal agents, by the use of saccharine substantially as set
forth.
2nd. The sweet coat, covering, envelope, or capsule for medicinal agents, obtained
by the addition of saccharine to the materials in common use, substantially as herein-
before described.