Manufacture of a Substance for Raising the Pressure of the Blood.
Year: 1898

page_text: Date of Application, 15th Oct., 1898
Complete Specification Left, 10th July, 1899-Accepted, 19th Aug., 1899
PROVISIONAL SPECIFICATION.
Manufacture of a Substance for Raising the Pressure of the Blood.
I, OLIVER IMRAY, of Birkbeck Bank Chambers, Southampton Buildings,
Chancery Lane, in the County of London, Chartered Patent Agent, do hereby
declare the nature of this invention (as communicated to me from abroad by
The Farbwerke vormals: Meister Lucius & Brüning of Hoechst a/Main, in the
Empire of Germany, Chemical Manufacturers) to be as follows:-
According to this invention, suprarenal capsules, reduced to pieces, are
extracted in a solution of zinc sulphate, and from the extract a substance for
raising the blood pressure is precipitated by ammonia as a zine compound.
The precipitate is washed, suspended in alcohol and decomposed by sulphuric
acid.
The acid alcoholic solution is reduced by treatment with zinc dust or other
appropriate reducing agent, then neutralized with zinc oxide and filtered. The
filtrate is freed from sulphate of zinc by means of alcohol and ether, its liquid
ingredients are evaporated off, and the residue dissolved in water is used for
medical purposes.
Dated this 15th day of October 1898
ABEL & IMRAY,
Agents for the Applicant.
COMPLETE SPECIFICATION.
Manufacture of a Substance for Raising the Pressure of the Blood;
I, OLIVER IMRAY, of Birkbeck Bank Chambers, Southampton Buildings,
Chancery Lane, in the County of London, Chartered Patent Agent, do hereby,
declare the nature of this invention (as communicated to me from abroad by
The Farbwerke vormals. Meister Lucius & Brüning of Hoechst a/Main, in the
Empire of Germany, Chemical Manufacturers,) and in what manner the same
is to be performed, to be particularly described and ascertained in and by the
following statement:—
According to this invention, suprarenal capsules reduced to pieces, are
extracted in a solution of zinc sulphate, and from the extract a substance for
raising the blood pressure is precipitated by ammonia as a zinc compound.
The precipitate is washed, suspended in alcohol and decomposed by sulphuric
acid.
The acid alcoholic solution is reduced by treatment with zinc dust or other
appropriate reducing agent, then neutralized with zine oxide and filtered. The

page_text: filtrate is freed from sulphate of zinc by means of alcohol and ether, and its liquid
ingredients are evaporated off.
The aqueous solution of the substance thus obtained becomes green when
treated with an acid solution of chloride of iron, and becomes red when treated
with an alcoholic solution of chloride of iron. When injected into the veins, it
raises the pressure of the blood.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I
claim is:
1. The herein described manufacture of a substance for raising the pressure of
the blood by extracting suprarenal capsules, with zinc sulphate, precipitating the
solution with ammonia, decomposing the precipitated zinc compound with an acid
and then reducing the acid solution.
2. The substance obtained from suprarenal capsules as above set forth.