Manufacture of Ethers of Para-lactyl-amido-phenol.
Year: 1895

page_text: Date of Application, 4th Feb., 1895
Complete Specification Left, 2nd Nov., 1895-Accepted, 7th Dec., 1895
[Communicated from abroad by THE FARBWERKE, vormals MEISTER LUCIUS
& BRUNING, of Hoechst a/Main, in the Empire of Germany, Chemical
Manufacturers.]
Manufacture of Ethers of Para-lactyl-amido-phenol.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention to be as follows:-
My foreign correspondents obtain lactyl-p-phenetidine and lactyl-p-anisidine by
heating p-amidophenol with lactic acid and by alkylising the p-lactylamidophenol
thus obtained by treating its salts with halogen derivatives of alcohol radicles
proceeding in the following manner :
Equal molecular proportions of p-amidophenol and lactic acid are heated to a
temperature of 170° to 180°. C. until the formation of water ceases.
The melt is dissolved in water and after the addition of animal charcoal is
crystallised from the aqueous solution.
Para-lactylamidophenol melts at 137° to 138° C.; it dissolves very easily in
alcohol, hot water and acetic ether and is soluble with difficulty in cold water,
benzene, ligroine and ether.
p-lactylamidophenol is dissolved in dilute alcohol and heated with the calculated
quantity of alkali and ethyl-bromide in a closed vessel on a waterbath from 4 to
5 hours. The alcohol is then distilled off and the residue is crystallised from hot
water.
In alkylising p-lactylphenetidine, for the ethyl bromide may be substituted ethyl-
chloride, ethyl-iodide or salts of ethyl-sulphuric acid.
By substituting methyl halogen derivatives of salts of methyl sulphuric acid for
the above mentioned ethyl compounds p-lactyl-anisidine is obtained.
Dated this 4th day of February 1895.
ABEL & IMRAY,
Agents for the Applicant.
Manufacture of Ethers of Para-lactyl-amido-phenol.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement:-
My foreign correspondents obtain iactyl-p-phenetidine and lactyl-p-anisidine by
heating p-amidophenol with lactic acid and by alkylising the p-lactyl-amidophenol
thus obtained by treating its salts with halogen derivatives of alcohol radicles,
proceeding in the following manner :
Equal molecular proportions of p-amidophenol and lactic acid are heated to a
temperature of 170° to 180° C. until the formation of water ceases.

page_text: The melt is dissolved in water and after the addition of animal charcoal is
crystallised from the aqueous solution.
Para-lactylamidophenol melts at 137° to 138° C.; it dissolves very easily in
alcohol, hot water and acetic ether and is soluble with difficulty in cold water,
benzene, ligroine and ether.
'
p-lactylamidophenol is dissolved in dilute alcohol and heated with the calculated
quantity of alkali and ethyl bromide in a closed vessel on a waterbath from 4 to
5 hours. The alcohol is then distilled off and the residue is crystallised from hot
water.
In alkylising p-lactylphenetidine, for the ethyl bromide may be substituted ethyl
chloride, ethyl iodide or salts of ethyl sulphuric acid.
By substituting methyl halogen derivatives of salts of methyl sulphuric acid for
the above mentioned ethyl compounds p-lactyl-anisidine is obtained.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I
claim is :-
:-
1. The herein described manufacture of lactyl-p-phenetidine and lactyl-p-anisidine
by preparing p-lactyl amidophenol by heating p-amidophenol with lactic acid, and
alkylising the salts of the p-lactyl amidophenol thus obtained with halogen.
derivatives of alcohol radicles or with salts of alkyl sulphuric acids.
2. The products obtained as set forth in the foregoing claim.
Dated this 2nd day of November 1895.
ABEL & IMRAY,
Agents for the Applicant.