CERTAIN MEANS OF TREATING QUININE AND IODINE, AND OTHER MINERAL MEDICINES, IN ORDER TO CAUSE THEM TO COMBINE WITH COD LIVER OIL, OR ANY OTHER FISH OIL, OR WITH SEED OIL
Year: 1855

page_text: LETTERS PATENT to John Horsley, of Cheltenham, in the County of
Gloucester, Analytical Chemist, for the Invention of "CERTAIN MEANS OF
TREATING QUININE AND IODINE, AND OTHER MINERAL MEDICINES, IN ORDER TO
CAUSE THEM TO COMBINE WITH COD LIVER OIL, OR ANY OTHER FISH OIL, OR
WITH SEED OIL."
Sealed the 4th April 1856, and dated the 11th December 1855.
PROVISIONAL SPECIFICATION left. by the said John Horsley at the
Office of the Commissioners of Patents, with his Petition, on the
11th December 1855.
I, JOHN HORSLEY, of Cheltenham, in the County of Gloster, Analytical
Chemist, do hereby. declare the nature of the said Invention for "CERTAIN
MEANS OF TREATING QUININE AND IODINE, AND OTHER MINERAL MEDICINES, IN
ORDER TO CAUSE THEM TO COMBINE WITH COD LIVER OIL, OR ANY OTHER FISH OIL,
OR WITH SEED OIL," to be as follows:-
1st. To. combine quinine and iodine with cod-liver oil, I first prepare the
quiuine by precipitation of a solution of the sulphate of quinine with an alkali,
and when the precipitated quinine is dry it is dissolved in ether and mixed
with cod-liver oil and stirred well. The heat suffices to dissipate the spirit,

page_text: and leave the cod oil charged with quinine. This solution of quinine in cod
oil is next iodised by trituration with iodine, which becomes dissolved.
2nd. To combine iodide of iron with cod-liver oil, I first triturate iron
filings in a mortar with dry iodine, so as to form iodide of iron, and then
triturate it with cod-liver oil and filter.
3rd. To combine bromide of iron with cod-liver oil, I proceed as in making
the iodide, substituting bromine for iodine.
4th. To combine lactate of iron with cod-liver oil, I first digest iron filings
in acid of milk, so as to form a lactate of iron, which on being dried is
triturated with hot cod-liver oil and filtered.
5th. To combine iodide of arsenic with cod-liver oil, I mix definite pro-
portions of iodine and arsenic, and either put them into a retort and sublime
the compound by heat, or boil the materials in water and evaporate the
solution to dryness, so as to form iodide of arsenic, which is afterwards
triturated with hot cod-liver oil and filtered.
4
6th. To produce arseniated cod-liver oil, I either triturate arsenic with hot
cod-liver oil, or put the materials into a pan and apply heat till solution takes
place.
7th. To produce mercurialized cod-liver oil, I proceed exactly, as in the last
case, substituting for arsenic the bichloride of mercury, or corrosive sublimate.
8th. To combine iodide of mercury with cod-liver oil, I first triturate
mercury with iodine in definite proportions in a mortar, together with a little
spirit of wine, so as to form the green iodide, which is afterwards treated with
hot cod-liver oil till dissolved, or heat may be applied to the vessel containing
the materials.
9th. To combine biniodide of mercury with cod-liver oil, I proceed as in the
last, except that a larger proportion of iodine is necessary to form the red
biniodide of mercury, which is afterwards treated with hot cod-liver oil to
effect the solution.
10th. To combine. iodide of zinc with cod-liver oil, I first make the iodide
of zinc, by digesting granulated zinc and iodine in water till the zinc becomes
dissolved. The solution on evaporation to dryness affords iodide of zinc; or
the zinc and iodine may be put into a retort and sublimed by the application
of heat. The iodide of zinc is afterwards treated with hot cod-liver oil.
:
In a similar way many other iodides may be formed, and solutions of the
same in cod-liver oil be obtained. Other than cod-liver oil may be made to
combine with the before-named medicines treated as aforesaid.

page_text: SPECIFICATION in pursuance of the conditions of the Letters Patent, filed
by the said John Horsley in the Great Seal 'Patent Office on the
11th June 1856.
TO ALL TO WHOM THESE PRESENTS SHALL COME, I, JOHN
HORSLEY, of Cheltenham, in the County of Gloucester, Analytical Chemist,
send greeting.
WHEREAS Her most Excellent Majesty Queen Victoria, by Her Letters
Patent, bearing date the Eleventh day of December, in the year of our
Lord One thousand eight hundred and fifty-five, in the nineteenth year of
Her reign, did, for Herself, Her heirs and successors, give and grant unto me,
the said John Horsley, Her special licence that I, the said John Horsley,
my executors, administrators, and assigns, or such others as I, the said
John Horsley, my executors, administrators, and assigns, should at any time
agree with, and no others, from time to time and all times thereafter
during the term therein expressed, should and lawfully might make, use,
exercise, and vend, within the United Kingdom of Great Britain and Ireland,
the Channel Islands, and Isle of Man, an Invention for "CERTAIN MEANS OF
TREATING QUININE AND IODINE, AND OTHER MINERAL MEDICINES, IN ORDER TO CAUSE
THEM TO COMBINE WITH COD LIVER OIL, OR ANY OTHER FISH OIL, OR WITH
SEED OIL," upon the condition (amongst others) that I, the said John
Horsley, my executors or administrators, by an instrument in writing under
my, or their, or one of their hands and seals, should particularly describe
and ascertain the nature of the said Invention, and in what manner the
same was to be performed, and cause the same to be filed in the Great
Seal Patent Office within six calendar months next and immediately after
the date of the said Letters Patent.
"
411
"
1.
NOW KNOW YE, that I, the said John Horsley, do hereby declare the
nature of my said Invention, and in what manner the same is to be per-
formed, to be particularly described and ascertained in and by the following
statement thereof (that is to say):-
By means of certain processes. I effect the combination or solution of
several medicines with cod-liver oil, or other fixed oil obtained from fish or
seed; but as cod-liver oil is that which will be chiefly used, I shall describe my
Invention as being performed with that oil only, and when any other oil of
any of the descriptions above mentioned shall be used in lieu thereof, it
only be necessary to substitute an equivalent proportion of such oil for the
cod-liver oil.
"
will

page_text: To combine quinine and iodine with cod-liver oil, I use the pure alkaloid
of either of the cinchona barks, known as quinine and cinchonine, and which
may be obtained by adding an alkali to a solution of sulphate of quinine or
cinchonine, so as to precipitate the alkaloid. I dissolve either of these
alkaloids in cod-liver oil heated to a temperature of about 140° of Fahrenheit's
thermometer in the proportion of about two grains of the alkaloid to the
ounce, continuing the heat until the solution is effected. I then take this
preparation whilst still warm, and triturate it with a quantity of iodine equi-
valent to a quarter of a grain for every ounce, and I continue the trituration
until the solution has been effected. The proportions which I have given for
combining these chemicals are, I think, the best, but they may of course be
somewhat varied.
To combine iodide of iron with cod-liver oil, I first dissolve iodine in cod-
liver oil at about the temperature above mentioned, or by trituration in cold
oil, the iodine being in the proportion of about 22 scruples to the gallon of
oil. I then add to the solution about 8 scruples Quevennes iron (as reduced
by hydrogen), and heat it to a temperature of about 180° Fahrenheit until a
combination of the iodine with the iron has been effected, which the chemist
will know by the color. I filter the preparation thus made, which is then
ready for use.
To combine bromide of iron with cod-liver oil, I first dissolve about 10
scruples of bromine in alcohol, and then mix it with an excess of iron filings
in order to insure the neutralization of the bromine. I heat this mixture till
it becomes colorless, and evaporate to dryness. I then treat the mass in one
gallon of cod-liver oil until it is dissolved, after which I filter the solution.
To combine acetate of iron with cod-liver oil, I first prepare the acetate as
follows: I take, say, one ounce of protosulphate of iron and two ounces of
acetate of potash, and rub them together in a mortar until the mixture
becomes a brown red paste, which is then dried and powdered. I heat this
dried product with one gallon of cod-liver oil to a temperature of about 140°,
and continue the heat until the acetate of iron is dissolved or the oil saturated,
after which I filter the solution.
To combine iodide of arsenic with cod-liver oil, I take about 32 grains of
freshly-made iodide of arsenic, and mix it with a gallon of cod-liver oil, and
heat to about 120°, continuing the heat until the iodide has been dissolved,
after which I filter the solution.
.
To combine iodide of arsenic and mercury with cod liver oil, I first prepare
the compound salt as follows:-I take the proportions of iodine, arsenic, and
mercury recommended by Donovan, and after dissolving them evaporate the

page_text: solution to dryness. I then dissolve the dry mixture in cod-liver oil in the
proportion of 64 grains of the dry mixture to every gallon of oil.
To combine iodide of zinc with 'cod-liver oil, I take that material freshly
prepared, and mix it with cod-liver oil in the proportion of about a grain and
a half of iodide of zinc to an ounce of oil, and then dissolve the iodide, and
filter the solution, in like manner as herein-before described with respect to
iodide of arsenic and cod-liver oil.
In order to effect a combination of iodide of iron and quinine or iodide of
iron and cinchonine with cod-liver oil, I make a solution of the iodide of iron
in oil, as before described, and also a solution of quinine or cinchonine in cod-
liver oil; as before described, and then mix those solutions together in equal
proportions, and filter the mixture. Solutions or combinations of other
substances with cod-liver oil may likewise be effected by these means, such
as solutions or combinations of cod-liver oil with valerianate of quinine,
valerianate of zinc, acetate of lead, and iodide of sulphur.
And having now described the nature of the said Invention, and in what
manner the same is to be performed, I declare that I claim the combination
of such medicines as aforesaid with cod-liver oil, or other oil of the kinds
before mentioned, in manner herein-before described.
In witness whereof, I, the said John Horsley, have hereunto set my
hand and seal, this Eleventh day of June, One thousand eight hundred
and fifty-six.
JOHN HORSLEY. (L.S.)