Manufacture of Mandelate of Antipyrine.
Year: 1894

page_text: Date of Application, 18th June, 1894
Complete Specification Left, 18th Mar., 1895-Accepted, 20th Apr., 1895
PROVISIONAL SPECIFICATION.
[Communicated from abroad by THE FARBWERKE, vormals MEISTER LUCIUS
AND BRUNING, of Hoechst a/ Main, in the Empire of Germany, Chemical
Manufacturers.]
Manufacture of Mandelate of Antipyrine.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention to be as follows:-
:-
This invention relates to the manufacture of mandelate of antipyrine, which is
effected by the combination of antipyrine and mandelic acid in molecular equivalents,
in the following manner:
188 parts by weight of antipyrine and 152 parts by weight of mandelic acid
are dissolved together in alcohol, benzene or other solvent, and the solvent is
evaporated; a colourless syrup is thus obtained which on standing for some time
solidifies to the condition of a hard crystalline mass.
The same compound is obtained by mixing antipyrine and mandelic acid, melting
the mixture on a water bath and letting it cool down.
Mandelate of antipyrine melts at 52° C.
It is soluble in nearly all solvents and separates out from them as an oil which
gradually solidifies. Solvents do not decompose it, but acids and alkalies easily
separate it into its components.
Dated this 18th day of June 1894
ABEL & IMRAY,
Agents for the Applicant.
Manufacture of Mandelate of Antipyrine.
I, OLIVER IMRAY, of No. 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement :—
This invention relates to the manufacture of mandelate of antipyrine which is
effected by the combination of antipyrine and mandelic acid in molecular equivalents,
in the following manner:
188 parts by weight of antipyrine and 152 parts by weight of mandelic acid
are dissolved together in alcohol, benzene or other solvent, and the solvent is
evaporated; a colourless syrup is thus obtained which on standing for some time
solidifies to the condition of a hard crystalline mass.
The same compound is obtained by mixing antipyrine and mandelic acid, melting
the mixture on a water bath and letting it cool down.
Mandelate of antipyrine melts at 52° C.

page_text: It is soluble in nearly all solvents and separates out from them as an oil which
gradually solidifies. Solvents do not decompose it, but acids and alkalies easily
separate it into its components.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I
claim is :-
1. The manufacture of mandelate of antipyrine by admixture of antipyrine with
mandelic acid in a solvent, and evaporating the solvent.
2. The manufacture of mandelate of antipyrine by melting a mixture of antipyrine
and mandelic acid.
3. Mandelate of antipyrine manufactured as above set forth.
Dated this 18th day of March 1895.
ABEL & IMRAY,
Agents for the Applicant.