Manufacture of Tropine.
Year: 1891

page_text: Date of Application, 26th Sept., 1891
Complete Specification Left, 27th June, 1892-Accepted, 30th July, 1892
PROVISIONAL SPECIFICATION.
[Communicated from abroad by THE FARBWERKE VORMALS MEISTER LUCIUS
AND BRUNING, of Hoechst " Maine, in the Empire of Germany.]
Manufacture of Tropine.
1, OLIVER IMRAY of 28 Southampton Buildings, Chancery Lane in the
County of London, Fellow of the Institute of Patent Agents, do hereby declare the
nature of this invention to be as follows:-
Dihydrobenzyldimethylamine, on being treated with hydrochloric acid, becomes
transformed into hydrochlorbenzyldimethylamine
The tropidine, on being boiled with soda-lye, produces tropine.
The dihydrobenzyldimethylamine CH,CH,N(CH,), which can be obtained in
several ways, for example from tropidine, is a thin liquid oil, which cannot be dis-
tilled without becoming changed; on being heated to 140° to 150° C. it becomes
transformed into an isomeric base, namely beta-methyltropidine.
The conversion of the dihydrobenzyldimethylamine into hydrobenzyldimethyl-
amine may be effected in the following manner:
To one part by weight of the base is added 1 part by weight of water, and
hydrochloric acid is caused to flow up to saturation into the liquid while it is
cooled by ice. After being left at rest for 24 hours the solution is poured into ice
water and the hydrochloric base is separated by means of soda lye; it is a thin
colourless oil; when it is heated on a water bath, a tenacious syrup is formed
which is the chlormethylate of tropidine. When the temperature is raised farther,
this methylate gently splits up into chlormethyl and tropidine.
When the tropidine is boiled for several hours in a vessel with reversed cooler
along with dilute soda lye, it disappears as tropidine, being transformed into tropine,
which can be taken up from the alkaline solution by chloroform.
Dated this 26th day of September 1891.
ABEL & IMRAY,
Agents for the Applicant.

page_text: COMPLETE SPECIFICATION.
Manufacture of Tropine.
I, OLIVER IMRAY, of 28 Southampton Buildings, Chancery Lane, in the
County of London, Chartered Patent Agent, do hereby declare the nature of this
invention and in what manner the same is to be performed to be particularly
described and ascertained in and by the following statement :-
Dihydrobenzyldimethylamine on being treated with hydrochloric acid becomes 5
transformed into hydrochlordihydrobenzyldimethylamine
OU
The tropidine on being boiled with soda lye produces tropine.
The dihydrobenzyldimethylamine CH, CH,.N(CH), which can be obtained
in several ways, for example from tropidine, is a thinly liquid oil, which cannot be
distilled without being changed; on being heated to from 140 to 150° C. it becomes
transformed into an isomeric base namely the beta-methyltropidine.
The conversion of the dihydrobenzyldimethylamine into hydrochlordihydro-
benzyldimethylamine may be effected in the following manner.
To 1 part by weight of the base is added 1 part by weight of water and hydro-
chloric acid is caused to flow up to saturation into the liquid while it is cooled by
ice. After being left at rest for 24 hours, the solution is poured into ice water
and the hydrochloric base is separated by means of soda lye, it is a thin colourless
oil, when it is heated on a water bath; a tenacious' syrup is thus formed which is
the chlormethylate of tropidine.
When the temperature is raised farther, this methylate gently splits up into
chlormethyl and tropidine.
When the tropidine is boiled for several hours in a vessel with reversed cooler
along with dilute soda lye, it disappears as tropidine being transformed into tropine,
which can be taken up from the alkaline solution by chloroform.
Having now particularly described and ascertained the nature of this inven-
tion and in what manner the same is to be performed, I declare that what I.
claim is :-
:-
1. The herein described process for production of tropine, by converting
dihydrobenzyldimethylamine by means of hydrochloric acid into hydrochlordihydro-
benzyldimethylamine, transforming this body by heat, first into chlormethylate of
tropidine and then into tropidine, and finally, by treating the tropidine with caustic
alkalies, converting it into tropine.
2. The tropine and the intermediary products, resulting from the above process.
Dated this 22nd day of June 1809
ABEL & IMRAY,
Agents for the Applicant.