PREPARATION OF NEW SOLUBLE NEUTRAL SALTS OF CERIUM FOR MEDICINAL PURPOSES
Year: 1884

page_text: COMPLETE SPECIFICATION.
JOHN BRUNT MACKEY 1 & 2 Bouveric Street, in the City of London
Manufacturing Chemist and Wholesale Druggist do hereby declare the nature of
my Invention for THE PREPARATION OF NEW SOLUBLE NEUTRAL SALTS OF CERIUM
FOR MEDICINAL PURPOSES and in what anner the same is to be performed,
to be particularly described and ascertained in and by the following statement :-
Cerium was introduced into medicine by Sir James Simpson about the year 1859,
the oxalate of corium being the salt used by him. He recommended cerium chiefly for
the cure of sick stomach arising from any cause but especially in the sickness of
pregnancy: he also found it of great value as a nerve tonic & used it with great
success in cases of chorea, epilepsy & other affections of the nervous system. The
oxalate of cerium as used by him is a neutral insoluble chemical compound of
corium & oxalic acid, its insolubility being a disadvantage which minimises the
beneficial therapeutic action, which attends the administration of a soluble neutral
salt of cerium,
There are soluble salts of cerium, compounds of cerium with the mineral acids
such as the sulphate of cerium, the nitrate of cerium & others but these are too
acid and astringent to be employed for medicinal purposes generally.
I have invented an entirely new class of salts of corium which are perfectly
neutral and soluble and form a valuable addition to the remedies for sickness
now in use.
On the 25th March 1880 I was granted Letters Patent for the preparation of the
soluble salt produced by the combination of citrate of cerium with citrate of
ammonia & I now describe the method I employ in preparing now soluble salts
of cerium by combination with other alkalis as hereinafter described.
I prepare hydrated acids of cerium by any well known method preferably
by precipitating hydrated oxide from nitrate or sulphate of cerium by means of
potassa or soda the necessary proportions & other particulars for effecting the
desired objects being well known to persons acquainted with chemical operations.
I convert hydrated oxide into the citrate or tartrate or lactate of cerium by
boiling in a solution of citric tartaric or lactic acid in chemical proportions.
I then dissolve the citrate or tartrate or lactate of cerium so formed in a solution
of citrate or tartrate or lactate of potassa or tartrate or lactate of ammonia or

page_text: citrate or tartrate or lactate of soda in chemical proportions so as to form a slightly
alkaline solution of the double citrates or tartrates or or lactates of ceriam & the
above mentioned alkalis soda, potassa, & ammonia.
For medicinal purposes I prefer to use the double citrates or tartrates or lactates
of cerium, as above specified in combination with some or all of the following
substances. Tincture of nux vomica, hydrocyanic acid pepsine, chloric æther
tincture of opium, spirits of chloroform, morphia, strychnia.
These substances are combined in the proportion of their respective doses which
vary with the malady to be treated.
Having now particularly described and ascertained the nature of my said
Invention and in what manner the same is to be performed I declare that what
I claim is:
1. The preparation of the salts of the double citrates of potassa & cerium.
2. The preparation of the salts of the double tartrates of potassa & corium.
3. The preparation of the salts of the double tartrates of ammonia & ceriun.
4. The preparation of the salts of the double citrates of soda & cerium.
5. The preparation of the salts of the double tartrates of soda & cerium.
6. The preparation of the salts of the double lactates of soda & cerium.
7. The preparation of the salts of the double lactates of ammonia & cerium.
8. The preparation of the salts of the double lactates of potassa & cerium.
9. The preparation of the salts of the double lactate cerium & citrate of
ammonia.
10. The preparation of the salts of the double lactate of cerium & citrate of
potassn.
11. The preparation of the salts of the double lactate of cerium & citrate of
soda.
12. The preparation of the salts of the double lactate of cerium & tartrate of
ammonia.
13. The preparation of the salts of the double lactate of cerium & tartrate of
potassa.
14. The preparation of the salts of the double lactate of cerium & tartrate of
soda substantially as hereinbefore described.
Dated this Twenty second day of March 1884.
JOHN BRINT MACKEY